Search of human proteins with 157389005

Search of human proteins with 157389005

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157389005 calpain 2 isoform 1 [Homo sapiens]
         (700 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157389005 calpain 2 isoform 1 [Homo sapiens]                      1435   0.0  
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                      1276   0.0  
gi|12408656 calpain 1, large subunit [Homo sapiens]                   953   0.0  
gi|221554549 calpain 8 [Homo sapiens]                                 920   0.0  
gi|215490104 calpain 11 [Homo sapiens]                                785   0.0  
gi|27765074 calpain 3 isoform c [Homo sapiens]                        737   0.0  
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                         726   0.0  
gi|27765072 calpain 3 isoform b [Homo sapiens]                        702   0.0  
gi|4557405 calpain 3 isoform a [Homo sapiens]                         700   0.0  
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                         687   0.0  
gi|47078247 calpain 3 isoform f [Homo sapiens]                        676   0.0  
gi|38707981 calpain 12 [Homo sapiens]                                 553   e-157
gi|223468608 calpain 14 [Homo sapiens]                                465   e-131
gi|37577157 calpain 5 [Homo sapiens]                                  344   1e-94
gi|41152101 calpain 13 [Homo sapiens]                                 311   1e-84
gi|13186316 calpain 6 [Homo sapiens]                                  294   2e-79
gi|27765076 calpain 3 isoform d [Homo sapiens]                        234   2e-61
gi|13186302 calpain 10 isoform a [Homo sapiens]                       220   3e-57
gi|89353291 calpain 10 isoform c [Homo sapiens]                       211   2e-54
gi|4502565 calpain, small subunit 1 [Homo sapiens]                    180   3e-45
gi|51599151 calpain, small subunit 1 [Homo sapiens]                   180   3e-45
gi|14161692 calpain small subunit 2 [Homo sapiens]                    170   5e-42
gi|27765080 calpain 3 isoform e [Homo sapiens]                        159   8e-39
gi|27765078 calpain 3 isoform e [Homo sapiens]                        159   8e-39
gi|5032105 small optic lobes [Homo sapiens]                           151   2e-36
gi|38679884 sorcin isoform b [Homo sapiens]                            94   4e-19
gi|4507207 sorcin isoform a [Homo sapiens]                             94   4e-19
gi|7656959 calpain 7 [Homo sapiens]                                    94   4e-19
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap...    92   1e-18
gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]            75   2e-13

>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score = 1435 bits (3714), Expect = 0.0
 Identities = 700/700 (100%), Positives = 700/700 (100%)

Query: 1   MAGIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGF 60
           MAGIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGF
Sbjct: 1   MAGIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGF 60

Query: 61  KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI 120
           KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI
Sbjct: 61  KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI 120

Query: 121 LARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL 180
           LARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL
Sbjct: 121 LARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL 180

Query: 181 LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGC 240
           LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGC
Sbjct: 181 LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGC 240

Query: 241 SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN 300
           SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN
Sbjct: 241 SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN 300

Query: 301 CPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK 360
           CPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK
Sbjct: 301 CPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK 360

Query: 361 MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQR 420
           MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQR
Sbjct: 361 MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQR 420

Query: 421 KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPG 480
           KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPG
Sbjct: 421 KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPG 480

Query: 481 EYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQ 540
           EYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQ
Sbjct: 481 EYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQ 540

Query: 541 LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL 600
           LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL
Sbjct: 541 LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL 600

Query: 601 WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFD 660
           WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFD
Sbjct: 601 WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFD 660

Query: 661 NFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL 700
           NFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL
Sbjct: 661 NFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL 700


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score = 1276 bits (3303), Expect = 0.0
 Identities = 621/621 (100%), Positives = 621/621 (100%)

Query: 80  EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 139
           EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF
Sbjct: 2   EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61

Query: 140 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 199
           HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA
Sbjct: 62  HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121

Query: 200 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 259
           TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181

Query: 260 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 319
           KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH
Sbjct: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241

Query: 320 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 379
           EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN
Sbjct: 242 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301

Query: 380 TFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEE 439
           TFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEE
Sbjct: 302 TFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEE 361

Query: 440 LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCI 499
           LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCI
Sbjct: 362 LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCI 421

Query: 500 RVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR 559
           RVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR
Sbjct: 422 RVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR 481

Query: 560 VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRS 619
           VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRS
Sbjct: 482 VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRS 541

Query: 620 GTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQL 679
           GTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQL
Sbjct: 542 GTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQL 601

Query: 680 DPENTGTIELDLISWLCFSVL 700
           DPENTGTIELDLISWLCFSVL
Sbjct: 602 DPENTGTIELDLISWLCFSVL 622


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  953 bits (2464), Expect = 0.0
 Identities = 441/696 (63%), Positives = 564/696 (81%), Gaps = 3/696 (0%)

Query: 3   GIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKE 62
           G++A++ K R    GLG HE AIKYL QDYE LR  CL++GTLF+D +FP +P +LG+K+
Sbjct: 13  GVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKD 72

Query: 63  LGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILA 122
           LGP SSKT GI+WKRPTE+ ++PQFI+ GATRTDICQGALGDCWLLAAIASLTLN+ +L 
Sbjct: 73  LGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLH 132

Query: 123 RVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLE 182
           RVVP  QSFQ  YAGIFHFQ WQ+GEWV+VVVDD LP KDG+L+FVHSAEG+EFWSALLE
Sbjct: 133 RVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLE 192

Query: 183 KAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI 242
           KAYAK+NG YEALSGG+T+EGFEDFTGG+ EWYEL+K P +L++II KAL++GSLLGCSI
Sbjct: 193 KAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSI 252

Query: 243 DITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCP 302
           DI+S  D EAITF+KLVKGHAYSVTGA++V   G +  LIR+RNPWGEVEWTG W+D+  
Sbjct: 253 DISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSS 312

Query: 303 SWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMD 362
            WN +DP ER++L  + EDGEFWMSF DF+R ++RLEICNLTPD L S T +KW  T  +
Sbjct: 313 EWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYE 372

Query: 363 GNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEE--DGESGCTFLVGLIQKHRRRQR 420
           G WRRGSTAGGCRNYP TFW+NPQ+ I+L+E D+ ++  D ESGC+F++ L+QKHRRR+R
Sbjct: 373 GTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRER 432

Query: 421 KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPG 480
           + G DM TIGF +YEVP EL GQ  +HL ++FFL N +R RS+ FINLREV  RF+LPPG
Sbjct: 433 RFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPG 492

Query: 481 EYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANL-EEFDISEDDIDDGFRRLFA 539
           EY++VPSTFEPNK+GDF +R FSEK A    +DD+I+ANL +E  +SE++ID+ F+ LF 
Sbjct: 493 EYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFR 552

Query: 540 QLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYI 599
           QLAGED EIS  EL+TIL R+++K +D+++ GFS+E+C+ MV+++D DG+GKLGL EF I
Sbjct: 553 QLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNI 612

Query: 600 LWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDF 659
           LW +I+ Y  I+R+ D+D+SG+M++YEMR A+E AGFK+  +L+++I+ R+++  L +DF
Sbjct: 613 LWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDF 672

Query: 660 DNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695
           DNFV CLVRLET+F+ FK LD +  G +  DL  WL
Sbjct: 673 DNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWL 708


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  920 bits (2377), Expect = 0.0
 Identities = 432/699 (61%), Positives = 554/699 (79%), Gaps = 3/699 (0%)

Query: 1   MAGIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGF 60
           MA  AA +++ R A +GLGS++ A+KYL QD++ LR +CL++G LF+DP FPA PSALG+
Sbjct: 1   MAAQAAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGY 60

Query: 61  KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI 120
           K+LGP S +T+GI WKRPTE+C  PQFI+GGATRTDICQG LGDCWLLAAIASLTLNEE+
Sbjct: 61  KDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEEL 120

Query: 121 LARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL 180
           L RVVP +Q FQENYAGIFHFQFWQYGEWVEVV+DDRLPTK+G+LLF+HS +G+EFWSAL
Sbjct: 121 LYRVVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSAL 180

Query: 181 LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGC 240
           LEKAYAK+NGCYEAL+GG+T EGFEDFTGGI+E+Y+LKKPP NL++II+KAL  GSLLGC
Sbjct: 181 LEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGC 240

Query: 241 SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN 300
           SID++SAA++EAIT QKLVK HAYSVTG EEV   G  +KLIR+RNPWGEVEW+G W+D+
Sbjct: 241 SIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDD 300

Query: 301 CPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK 360
            P WN IDP  +E L ++ EDGEFWMS SDF+R +SRLEICNL+PD+L+S+   KW L  
Sbjct: 301 APEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVL 360

Query: 361 MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEED--GESGCTFLVGLIQKHRRR 418
            +G+W RGSTAGGC+NYP T+W NPQ+ I+L+E DED+E+  GE  CT L+GL+QK+RR 
Sbjct: 361 FNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRW 420

Query: 419 QRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLP 478
           ++++G+ M +IG+ +Y+VP+EL   T+ HL ++FFL  +   R+ T++NLREV  R +LP
Sbjct: 421 RKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLP 480

Query: 479 PGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISE-DDIDDGFRRL 537
           PGEY++VPSTFEP KDG+FC+RVFSEKKA    + D +  N  E   SE D  DD FRRL
Sbjct: 481 PGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRL 540

Query: 538 FAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEF 597
           F +LAG+D+EI+A  L+ +L    +KR DIK DGF+I TC+ M+ +LDS+G+G LG  EF
Sbjct: 541 FEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEF 600

Query: 598 YILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLII 657
             LW KIQKY +IY E D + SGT++++EMR AL +AGF +  Q+ Q I  R+A  +L I
Sbjct: 601 KTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGI 660

Query: 658 DFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLC 696
           +FD+FV C++RLETLFK+F  LD +  G ++L L  WLC
Sbjct: 661 NFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLC 699


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  785 bits (2027), Expect = 0.0
 Identities = 368/697 (52%), Positives = 501/697 (71%), Gaps = 4/697 (0%)

Query: 3   GIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKE 62
           G+ A +   R  A+G+G H+ A  + NQ +E LR  CL  G LF+DP FPA PS+LGFK+
Sbjct: 37  GMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKD 96

Query: 63  LGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILA 122
           LGP S   + I W+RP +I  +P FI+ G + TDICQG LGDCWLLAAI SLT   ++L 
Sbjct: 97  LGPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLY 156

Query: 123 RVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLE 182
           RVVP  QSF++NYAGIFHFQ WQ+G+WV VVVDDRLPTK+ +L+FVHS E SEFWSALLE
Sbjct: 157 RVVPRGQSFKKNYAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLE 216

Query: 183 KAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI 242
           KAYAK++G YEALSGG+T EG EDFTGG+A+ ++L++PP NL ++++KA+++ SL+GCSI
Sbjct: 217 KAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSI 276

Query: 243 DITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCP 302
           ++TS ++ E++T + LV+GHAYSVTG ++V   G ++ LIR+RNPWG +EW G W+D+  
Sbjct: 277 EVTSDSELESMTDKMLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAR 336

Query: 303 SWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMD 362
            W  +  + + +L  + EDGEFWMS+ DFL +++ LEICNLTPDTL+ D    W  T  +
Sbjct: 337 EWEEVASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYE 396

Query: 363 GNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESG---CTFLVGLIQKHRRRQ 419
           G+WRRGS+AGGCRN+P TFW NPQ+ I L E D+ E+D E     CT LV L+QK+ R  
Sbjct: 397 GSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHA 456

Query: 420 RKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPP 479
           R+ G  + TIGF +Y VP+E     ++HL K FF   +    S+ F N REV ++ +LPP
Sbjct: 457 RQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPP 516

Query: 480 GEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDD-EIEANLEEFDISEDDIDDGFRRLF 538
           GEYI++PSTFEP++D DF +RVF+EK ++   +D+      L+E  +SEDD+D  F  LF
Sbjct: 517 GEYIIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLF 576

Query: 539 AQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFY 598
             +AGE  EI  +ELQ +L R+  K +  K+ GF ++ C+ M++++D DGSGKLGL EF 
Sbjct: 577 KIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFK 636

Query: 599 ILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIID 658
           ILW K++K+  I+RE D D SGT+NSYEMR  +E+AG K+  ++ QV+VAR+ADD LIID
Sbjct: 637 ILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIID 696

Query: 659 FDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695
           FD+F+ C +RL+T+F  F  +DP+NTG I L L  WL
Sbjct: 697 FDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWL 733


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score =  737 bits (1903), Expect = 0.0
 Identities = 347/669 (51%), Positives = 478/669 (71%), Gaps = 11/669 (1%)

Query: 32  YEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGG 91
           +E L  +CLE   L+ DP FP   ++L + +  P         WKRP EIC +P+FII G
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115

Query: 92  ATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVE 151
           A RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIFHFQFW+YGEWV+
Sbjct: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175

Query: 152 VVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGI 211
           VV+DD LPT + +L+F  S   +EFWSALLEKAYAK++G YEAL GG TTE  EDFTGG+
Sbjct: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235

Query: 212 AEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEE 271
           AE++E++  P +++KI++KA+++GSL+GCSID       E      LV+GHAYSVTG +E
Sbjct: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDE 295

Query: 272 VESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSD 330
           V   G   KL+R+RNPWG+VEW G W+D    W+ +D +E+ RL  +  EDGEFWMS+ D
Sbjct: 296 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 355

Query: 331 FLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIK 390
           F+ H+++LEICNLT D L SD  + W ++  +G W RG +AGGCRN+P+TFW NPQY +K
Sbjct: 356 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 415

Query: 391 LEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSK 450
           L EED+D +D E  C+FLV L+QK+RR+ RK+G  + TIGF IYEVP+E+ G    HL K
Sbjct: 416 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQK 474

Query: 451 NFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQ 510
           +FFL N ++ RS T+IN+REV  RF+LPP EY++VPST+EP+++G+F +RVFSEK+   +
Sbjct: 475 DFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSE 534

Query: 511 AVDDEIEAN----LEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQD 566
            V++ I  +           E +    FR +F Q+AG+D EI A EL+ +L  V+ K +D
Sbjct: 535 EVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKD 594

Query: 567 IKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYE 626
           +K+ GF++E+C+ M+ ++D+DGSGKL L+EF+ LW KI+ +QKI++  D D+SGT+NSYE
Sbjct: 595 LKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYE 654

Query: 627 MRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGT 686
           MR A+ +AGF +  QL+ +I  R+AD  + IDFD+F+ C VRLE +F+ F   D +  G 
Sbjct: 655 MRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGI 714

Query: 687 IELDLISWL 695
           I+L+++ WL
Sbjct: 715 IKLNVLEWL 723


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score =  726 bits (1873), Expect = 0.0
 Identities = 351/668 (52%), Positives = 481/668 (72%), Gaps = 20/668 (2%)

Query: 30  QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFII 89
           Q +E +R ECL+ GTLF+D  FPA  S+L + E            WKRP EI  +P+FI+
Sbjct: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIP-----FVWKRPGEIVKNPEFIL 81

Query: 90  GGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEW 149
           GGATRTDICQG LGDCWLLAAIASLTLN++ LARV+P +QSF   YAGIFHFQFWQ+ EW
Sbjct: 82  GGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEW 141

Query: 150 VEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTG 209
           ++VV+DDRLPT    L+F+HSA+ +EFWSALLEKAYAK+NG YEAL GG+  E  EDFTG
Sbjct: 142 LDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201

Query: 210 GIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGA 269
           G+AE ++ K+ P N ++I++KAL++GSLLGC ID  SAA+SEA T   L+KGHAYSVTG 
Sbjct: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGI 261

Query: 270 EEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH-EDGEFWMSF 328
           ++V   G   +LIRIRNPWG+VEW G W+D+ P W ++ P E++RL     +DGEFWM+F
Sbjct: 262 DQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAF 321

Query: 329 SDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYL 388
            DF  H+ ++EICNLTPD L  D   KW++T   G+W RGSTAGGCRN+ +TFW NPQ  
Sbjct: 322 KDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIK 381

Query: 389 IKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHL 448
           + L E+DE +E+    C+FLV L+QK RR+ ++ G ++ TIG+ IYE P++     + HL
Sbjct: 382 LSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----DEHL 432

Query: 449 SKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKAD 508
           +K+FF  + +R RS TFINLREV +RFKLPPGEYIL+PSTFEP+++ DFC+R+FSEKKA 
Sbjct: 433 NKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAI 492

Query: 509 YQAVDDEIEANLEE-----FDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAK 563
            + +D  ++ +L E         E + +  FR LF Q+AGED E++A EL+ +L  VL K
Sbjct: 493 TRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQK 552

Query: 564 RQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMN 623
           ++DIK    S+ +CK ++ ++D+ G+GKL   EF + W K++++  ++   D D+SGTM+
Sbjct: 553 KKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMS 612

Query: 624 SYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPEN 683
           +YE+R AL+ AGF++   L Q+IV R+AD++L +DFD+F+ CLVRLE   ++F+ L  +N
Sbjct: 613 TYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKN 672

Query: 684 TGTIELDL 691
              I L++
Sbjct: 673 KEFIHLNI 680


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score =  702 bits (1813), Expect = 0.0
 Identities = 349/755 (46%), Positives = 487/755 (64%), Gaps = 97/755 (12%)

Query: 32  YEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGG 91
           +E L  +CLE   L+ DP FP   ++L + +  P         WKRP EIC +P+FII G
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115

Query: 92  ATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVE 151
           A RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIFHFQFW+YGEWV+
Sbjct: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175

Query: 152 VVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGI 211
           VV+DD LPT + +L+F  S   +EFWSALLEKAYAK++G YEAL GG TTE  EDFTGG+
Sbjct: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235

Query: 212 AEWYELKKPPPNLFKIIQKALQKGSLLGCSI----------------------------D 243
           AE++E++  P +++KI++KA+++GSL+GCSI                            D
Sbjct: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295

Query: 244 ITSAADSEA---------------ITFQK-----LVKGHAYSVTGAEEVESNGSLQKLIR 283
            +   DS+                + ++      LV+GHAYSVTG +EV   G   KL+R
Sbjct: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355

Query: 284 IRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSDFLRHYSRLEICN 342
           +RNPWG+VEW G W+D    W+ +D +E+ RL  +  EDGEFWMS+ DF+ H+++LEICN
Sbjct: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415

Query: 343 LTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGE 402
           LT D L SD  + W ++  +G W RG +AGGCRN+P+TFW NPQY +KL EED+D +D E
Sbjct: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSE 475

Query: 403 SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERS 462
             C+FLV L+QK+RR+ RK+G  + TIGF IYEVP+E+ G    HL K+FFL N ++ RS
Sbjct: 476 VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASKARS 534

Query: 463 DTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANL-- 520
            T+IN+REV  RF+LPP EY++VPST+EP+++G+F +RVFSEK+   + V++ I  +   
Sbjct: 535 KTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV 594

Query: 521 ------------EEFDI----------------------------SEDDIDDGFRRLFAQ 540
                       +E  +                             E +    FR +F Q
Sbjct: 595 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 654

Query: 541 LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL 600
           +AG+D EI A EL+ +L  V+ K +D+K+ GF++E+C+ M+ ++D+DGSGKL L+EF+ L
Sbjct: 655 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 714

Query: 601 WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFD 660
           W KI+ +QKI++  D D+SGT+NSYEMR A+ +AGF +  QL+ +I  R+AD  + IDFD
Sbjct: 715 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 774

Query: 661 NFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695
           +F+ C VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 775 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 809


>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score =  700 bits (1807), Expect = 0.0
 Identities = 349/761 (45%), Positives = 487/761 (63%), Gaps = 103/761 (13%)

Query: 32  YEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGG 91
           +E L  +CLE   L+ DP FP   ++L + +  P         WKRP EIC +P+FII G
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115

Query: 92  ATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVE 151
           A RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIFHFQFW+YGEWV+
Sbjct: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175

Query: 152 VVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGI 211
           VV+DD LPT + +L+F  S   +EFWSALLEKAYAK++G YEAL GG TTE  EDFTGG+
Sbjct: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235

Query: 212 AEWYELKKPPPNLFKIIQKALQKGSLLGCSI----------------------------D 243
           AE++E++  P +++KI++KA+++GSL+GCSI                            D
Sbjct: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295

Query: 244 ITSAADSEA---------------ITFQK-----LVKGHAYSVTGAEEVESNGSLQKLIR 283
            +   DS+                + ++      LV+GHAYSVTG +EV   G   KL+R
Sbjct: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355

Query: 284 IRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSDFLRHYSRLEICN 342
           +RNPWG+VEW G W+D    W+ +D +E+ RL  +  EDGEFWMS+ DF+ H+++LEICN
Sbjct: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415

Query: 343 LTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGE 402
           LT D L SD  + W ++  +G W RG +AGGCRN+P+TFW NPQY +KL EED+D +D E
Sbjct: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSE 475

Query: 403 SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERS 462
             C+FLV L+QK+RR+ RK+G  + TIGF IYEVP+E+ G    HL K+FFL N ++ RS
Sbjct: 476 VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASKARS 534

Query: 463 DTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANL-- 520
            T+IN+REV  RF+LPP EY++VPST+EP+++G+F +RVFSEK+   + V++ I  +   
Sbjct: 535 KTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV 594

Query: 521 ------------------EEFDI----------------------------SEDDIDDGF 534
                             +E  +                             E +    F
Sbjct: 595 KKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQF 654

Query: 535 RRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGL 594
           R +F Q+AG+D EI A EL+ +L  V+ K +D+K+ GF++E+C+ M+ ++D+DGSGKL L
Sbjct: 655 RNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNL 714

Query: 595 KEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQ 654
           +EF+ LW KI+ +QKI++  D D+SGT+NSYEMR A+ +AGF +  QL+ +I  R+AD  
Sbjct: 715 QEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKH 774

Query: 655 LIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695
           + IDFD+F+ C VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 775 MNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 815


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score =  687 bits (1774), Expect = 0.0
 Identities = 340/667 (50%), Positives = 464/667 (69%), Gaps = 44/667 (6%)

Query: 30  QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFII 89
           Q +E +R ECL+ GTLF+D  FPA  S+L + E            WKRP EI  +P+FI+
Sbjct: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIP-----FVWKRPGEIVKNPEFIL 81

Query: 90  GGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEW 149
           GGATRTDICQG LGDCWLLAAIASLTLN++ LARV+P +QSF   YAGIFHFQFWQ+ EW
Sbjct: 82  GGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEW 141

Query: 150 VEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTG 209
           ++VV+DDRLPT    L+F+HSA+ +EFWSALLEKAYAK+NG YEAL GG+  E  EDFTG
Sbjct: 142 LDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201

Query: 210 GIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGA 269
           G+AE ++ K+ P N ++I++KAL++GSLLGC ID  SAA+SEA T   L+KGHAYSVTG 
Sbjct: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGI 261

Query: 270 EEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSFS 329
           ++V   G   +LIRIRNPWG+VEW G W+D                          M+F 
Sbjct: 262 DQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFK 296

Query: 330 DFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLI 389
           DF  H+ ++EICNLTPD L  D   KW++T   G+W RGSTAGGCRN+ +TFW NPQ  +
Sbjct: 297 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKL 356

Query: 390 KLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLS 449
            L E+DE +E+    C+FLV L+QK RR+ ++ G ++ TIG+ IYE P++     + HL+
Sbjct: 357 SLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----DEHLN 407

Query: 450 KNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADY 509
           K+FF  + +R RS TFINLREV +RFKLPPGEYIL+PSTFEP+++ DFC+R+FSEKKA  
Sbjct: 408 KDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAIT 467

Query: 510 QAVDDEIEANLEE-----FDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKR 564
           + +D  ++ +L E         E + +  FR LF Q+AGED E++A EL+ +L  VL K+
Sbjct: 468 RDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKK 527

Query: 565 QDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNS 624
           +DIK    S+ +CK ++ ++D+ G+GKL   EF + W K++++  ++   D D+SGTM++
Sbjct: 528 KDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMST 587

Query: 625 YEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENT 684
           YE+R AL+ AGF++   L Q+IV R+AD++L +DFD+F+ CLVRLE   ++F+ L  +N 
Sbjct: 588 YELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNK 647

Query: 685 GTIELDL 691
             I L++
Sbjct: 648 EFIHLNI 654


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score =  676 bits (1744), Expect = 0.0
 Identities = 337/720 (46%), Positives = 470/720 (65%), Gaps = 94/720 (13%)

Query: 67  SSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVP 126
           S KT+  + K   EIC +P+FII GA RTDICQG LGDCW LAAIA LTLN+ +L RV+P
Sbjct: 6   SLKTQTTQQKN--EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIP 63

Query: 127 LNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYA 186
            +QSF ENYAGIFHFQFW+YGEWV+VV+DD LPT + +L+F  S   +EFWSALLEKAYA
Sbjct: 64  HDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYA 123

Query: 187 KINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI---- 242
           K++G YEAL GG TTE  EDFTGG+AE++E++  P +++KI++KA+++GSL+GCSI    
Sbjct: 124 KLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGT 183

Query: 243 ------------------------DITSAADSEA---------------ITFQK-----L 258
                                   D +   DS+                + ++      L
Sbjct: 184 NMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGL 243

Query: 259 VKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR 318
           V+GHAYSVTG +EV   G   KL+R+RNPWG+VEW G W+D    W+ +D +E+ RL  +
Sbjct: 244 VRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQ 303

Query: 319 -HEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNY 377
             EDGEFWMS+ DF+ H+++LEICNLT D L SD  + W ++  +G W RG +AGGCRN+
Sbjct: 304 VTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNF 363

Query: 378 PNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVP 437
           P+TFW NPQY +KL EED+D +D E  C+FLV L+QK+RR+ RK+G  + TIGF IYEVP
Sbjct: 364 PDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVP 423

Query: 438 EELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDF 497
           +E+ G    HL K+FFL N ++ RS T+IN+REV  RF+LPP EY++VPST+EP+++G+F
Sbjct: 424 KEMHGNKQ-HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEF 482

Query: 498 CIRVFSEKKADYQAVDDEIEANL--------------EEFDI------------------ 525
            +RVFSEK+   + V++ I  +               +E  +                  
Sbjct: 483 ILRVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQ 542

Query: 526 ----------SEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIE 575
                      E +    FR +F Q+AG+D EI A EL+ +L  V+ K +D+K+ GF++E
Sbjct: 543 SPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLE 602

Query: 576 TCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAG 635
           +C+ M+ ++D+DGSGKL L+EF+ LW KI+ +QKI++  D D+SGT+NSYEMR A+ +AG
Sbjct: 603 SCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAG 662

Query: 636 FKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695
           F +  QL+ +I  R+AD  + IDFD+F+ C VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 663 FHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 722


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  553 bits (1425), Expect = e-157
 Identities = 300/711 (42%), Positives = 417/711 (58%), Gaps = 37/711 (5%)

Query: 11  DREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKT 70
           D EA  G G   R   +  Q YEA+R  CL++G LF+DP FPA P ALG+ +LGP S K 
Sbjct: 14  DEEAGVGAG---RLQLFRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKA 70

Query: 71  RGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQS 130
           +G++W RP E CA+P+FI    +RTD+CQG+LG+CW LAA ASLTL   +L RVVP  Q 
Sbjct: 71  KGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQD 130

Query: 131 FQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKING 190
           FQ  YAG+FHFQ WQ+G W++VVVDDRLP ++G+L+FV S + +EFW+ LLEKAYAK++G
Sbjct: 131 FQHGYAGVFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHG 190

Query: 191 CYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAAD- 249
            YE + GG   E F DFTGG+ E   L++    LF  ++ AL K SL+G     T+ +D 
Sbjct: 191 SYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGA----TALSDR 246

Query: 250 SEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDP 309
            E  T + LVKGHAYS+TG  +V    +  +L+R+RNPWG VEWTG W+D+CP W+T+  
Sbjct: 247 GEYRTEEGLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPT 306

Query: 310 EERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTL-TSDTYKKWKLTKMDGNWRRG 368
           E R+ L  + EDGEFWM   DFL H+  ++IC+L+P+ L  S     W +    G W RG
Sbjct: 307 ECRDALLVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRG 366

Query: 369 STAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESG---------------------CTF 407
             +GG +    TFW NPQ+ + L E DE++++ E G                     CT 
Sbjct: 367 FNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTV 426

Query: 408 LVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFIN 467
           L+ LIQ++RRR R  G    T+GF ++++PEEL G  +   S +  L    R        
Sbjct: 427 LLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRS-HALLPRLLRADRSPLSA 485

Query: 468 LREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISE 527
            R+V  R  L PG Y++VPST     + DF +RVFSE++     +DD I A+L+      
Sbjct: 486 RRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPY 545

Query: 528 DDIDDGFRRLFAQLAGEDAEISAFELQTILRRVL--AKRQDIKSDGFSIETCKIMVDMLD 585
             ++ G  +LF +LAGE+ E++A +LQ +L   L  A+          + TC+    +L 
Sbjct: 546 LPLELGLEQLFQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCE---QLLQ 602

Query: 586 SDGSGK-LGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQ 644
             G G+ L L  F  LW  + ++Q I+ + D D SGTMNSYE+R AL  AGF +  QL Q
Sbjct: 603 CFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQ 662

Query: 645 VIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695
            + +R+ D +L +DF+ FV C+  L  +F    Q      G I L    W+
Sbjct: 663 TLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWM 713


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  465 bits (1196), Expect = e-131
 Identities = 254/672 (37%), Positives = 382/672 (56%), Gaps = 19/672 (2%)

Query: 30  QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFII 89
           QD+EAL  ECL  G LF+D SFPA  S++G   L         ++WKRP E+ ++PQF  
Sbjct: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSL--LQKLPPRLQWKRPPELHSNPQFYF 85

Query: 90  GGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEW 149
             A R D+CQG +GDCW LAA+ +L L+++IL+RVVPLNQSF E YAGIF F FW YG W
Sbjct: 86  AKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNW 145

Query: 150 VEVVVDDRLPTKD-GELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFT 208
           V VV+DDRLP  + G+L+FV S   + FW ALLEKAYAK++G YE L  G  +E   DFT
Sbjct: 146 VPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205

Query: 209 GGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTG 268
           GG+     L +   NL+ I+ +A    +L+GC          E I    LV+GHAY++TG
Sbjct: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGC-----QTHSGEKILENGLVEGHAYTLTG 260

Query: 269 AEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSF 328
             +V      + L+++RNPWG+VEW G W+D+   W  + P+E+  L R+  DGEFWM+ 
Sbjct: 261 IRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTL 320

Query: 329 SDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRN-YPNTFWMNPQY 387
            DF  H+  L IC LTP  L+ +  +KW  T  +G W + STAGG R    +TFW NPQ+
Sbjct: 321 QDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQF 380

Query: 388 LIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIH 447
           L+ +   +E        C+ LV L+QK R R RK  + +  IGF +Y + +    Q    
Sbjct: 381 LLSVWRPEEGRRSLRP-CSVLVSLLQKPRHRCRKR-KPLLAIGFYLYRMNKYHDDQR--R 436

Query: 448 LSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKA 507
           L   FF  N    + D F+  +EV     L PG Y++VP   E ++  +F +RVFS K  
Sbjct: 437 LPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHI 496

Query: 508 DYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDI 567
            Y+   +      +E +   +  D+ F + F     +  EI+A +LQ +L ++       
Sbjct: 497 FYEIGSNSGVVFSKEIEDQNERQDEFFTKFFE----KHPEINAVQLQNLLNQMTWSSLGS 552

Query: 568 KSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEM 627
           +   FS+E C+ ++ +LD + SG + ++EF  LW +++  QK++ + D   SG +N  ++
Sbjct: 553 RQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD-RGSGYLNWEQL 611

Query: 628 RKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTI 687
             A+ EAG  +   + Q+++ R+   +L +DF +F+  ++R+E +  +F+ L  +  G I
Sbjct: 612 HAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKG-I 670

Query: 688 ELDLISWLCFSV 699
            L    W+  ++
Sbjct: 671 YLQKPEWMMMAL 682


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  344 bits (883), Expect = 1e-94
 Identities = 191/508 (37%), Positives = 286/508 (56%), Gaps = 55/508 (10%)

Query: 27  YLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKEL-GPYSSKTRGIEWKRPTEICADP 85
           Y +Q+Y ALR +C     LF+DP FPA   +L +K   GP       + WKRP  IC DP
Sbjct: 8   YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGP------AVRWKRPKGICEDP 61

Query: 86  QFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVP------LNQSFQENYAGIF 139
           +  + G +  D+ QG +G+CW +AA +SL   E +  +V+P       +      YAGIF
Sbjct: 62  RLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIF 121

Query: 140 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 199
           HF FW++GEWV+VV+DDRLPT + +L++ HS   +EFW AL+EKAYAK+ GCY+AL GG 
Sbjct: 122 HFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGN 181

Query: 200 TTEGFEDFTGGIAEWYEL--------KKPPPNLFKIIQKALQKGSLLGCSIDITSAADSE 251
           T +   DFTGG++E  +L        +     LF+ + K   +G L+  SI   +AAD E
Sbjct: 182 TADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADME 241

Query: 252 AITFQKLVKGHAYSVTGAEEVESNGSL------QKL--IRIRNPWGEVEWTGRWNDNCPS 303
           A     LVKGHAY+VT   +V     L      +KL  IR+RNPWGE EW G W+D    
Sbjct: 242 ARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEE 301

Query: 304 WNTIDPEERERL-TRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMD 362
           W  +   ERE++     +DGEFWM+F D  R+++ +  C +  +T     +K W+  ++ 
Sbjct: 302 WQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVI-NTSHLSIHKTWEEARLH 360

Query: 363 GNWR-----RGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRR 417
           G W      R +  GGC N+ +TF+ NPQY+ ++++ +++          L+ + Q+ +R
Sbjct: 361 GAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDE---------VLICIQQRPKR 411

Query: 418 RQRKMGEDMH-TIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFK 476
             R+ G+  +  IGF IY+V E  + Q  +H  ++       +  S  +IN R V  R  
Sbjct: 412 STRREGKGENLAIGFDIYKVEE--NRQYRMHSLQH-------KAASSIYINSRSVFLRTD 462

Query: 477 LPPGEYILVPSTFEPNKDGDFCIRVFSE 504
            P G Y+++P+TFEP   G+F +RVF++
Sbjct: 463 QPEGRYVIIPTTFEPGHTGEFLLRVFTD 490


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  311 bits (798), Expect = 1e-84
 Identities = 208/681 (30%), Positives = 330/681 (48%), Gaps = 41/681 (6%)

Query: 25  IKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICAD 84
           IK+ +QD+  LR+ CL  G  F+D +FPA  S++G K L     +   + WKRP ++   
Sbjct: 14  IKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLL--QEKRLSNVIWKRPQDLPGG 71

Query: 85  P-QFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQF 143
           P  FI+   +R DI QG   DCW LAA+ SLT N +   +++ + QSF   YAGIF F+F
Sbjct: 72  PPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRF 130

Query: 144 WQYGEWVEVVVDDRLPTKDGELLFVHSA-EGSEFWSALLEKAYAKINGCYEALSGGATTE 202
           WQ G+WVEVV+DDRLP +  + LFV    +  EFW  LLEKAYAK+ G Y  L  G   +
Sbjct: 131 WQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLED 190

Query: 203 GFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGH 262
              D TGG+     L   P +L K ++ A + GSL+ C+   +   D+       LV  H
Sbjct: 191 ALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATP-SGPTDTAQAMENGLVSLH 249

Query: 263 AYSVTGAEEVESNGSLQKLIRIRNPWG--EVEWTGRWNDNCPSWNTIDPEERERLTRRHE 320
           AY+VTGAE+++     +++I + NPWG  E EW GRW+D    W       + +L ++ E
Sbjct: 250 AYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRE 309

Query: 321 DGEFWMSFSDFLRHYSRLEICNLTPDTLT--SDTYKKWKLTKMDGNWRRGSTAGGCRNYP 378
           DGEFWMS  DF + +  + IC+  P TL   +  ++ W           G+TAGG RN  
Sbjct: 310 DGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-- 367

Query: 379 NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE 438
                + Q+   ++E  E        C  +       +    K   D   I  G     E
Sbjct: 368 -----DAQFNFSVQEPMEG--TNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFRE 420

Query: 439 ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC 498
           +            FF + R   +S      R     + L PG Y++V  T    K  +F 
Sbjct: 421 K--------FPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFL 470

Query: 499 IRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR 558
           +R+F +     + +       ++             + +F + A +  +I A +LQ +L 
Sbjct: 471 LRIFLKMPDSDRHLSSHFNLRMK----GSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLN 526

Query: 559 RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR 618
           + L        D FS++ C+ +V +++   +G+L  +EF  LW ++  YQ +++++    
Sbjct: 527 QELLTGP--PGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTS- 583

Query: 619 SGTMNSYEMRKALEEA----GFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFK 674
            G + S ++ KA+E      G  +  +L  ++  R++D    + F + V  L+RLE + K
Sbjct: 584 PGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAK 643

Query: 675 IFKQLDPENTGTIELDLISWL 695
            F+ L  +  G + L  + W+
Sbjct: 644 TFRNLSKDGKG-LYLTEMEWM 663


>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score =  294 bits (752), Expect = 2e-79
 Identities = 181/550 (32%), Positives = 287/550 (52%), Gaps = 60/550 (10%)

Query: 27  YLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQ 86
           + NQ Y+ L+ EC++   LF DP+F     +L +  L P       + WKRP +IC DP 
Sbjct: 8   FKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK-----VVWKRPQDICDDPH 62

Query: 87  FIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQ------ENYAGIFH 140
            I+G  +   + QG LG   +++A + L + E    + +P ++  +      E YAGIFH
Sbjct: 63  LIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFH 122

Query: 141 FQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGAT 200
           F+FW +GEW EVV+DD LPT +G+L+F  S   +EFW+ALLEKAYAK+ GCYEAL G   
Sbjct: 123 FRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTI 182

Query: 201 TEGFEDFTGGIAE--------WYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEA 252
           T+   DFTG +AE        + EL +    LF  + K   KG L+ CSI+  +  + E 
Sbjct: 183 TDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEV 242

Query: 253 ITFQKLVKGHAYSVTGAEEVESNGSLQK--------LIRIRNPWGEVEWTGRWNDNCPSW 304
            T   L+KGH Y++T   ++     L +        ++R+RNP G  EW+G W++    W
Sbjct: 243 ETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEW 302

Query: 305 NTIDPEERERL-TRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDG 363
             +   +R+ L     +DGEFWMS  DF R++ +L +C      + +  + + +L  + G
Sbjct: 303 QQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCR----NVNNPIFGRKELESVLG 358

Query: 364 NWRRG-----STAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRR 418
            W        + +GGC N  +TF  NPQY+  + E+         G   ++ L QK  R 
Sbjct: 359 CWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPED---------GHKVIMSLQQKDLRT 409

Query: 419 QRKMGE-DMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKL 477
            R+MG  D + IGF +++V  E++ +  +H   + ++  RA   + T+I+ R V     L
Sbjct: 410 YRRMGRPDNYIIGFELFKV--EMNRKFRLH---HLYIQERA--GTSTYIDTRTVFLSKYL 462

Query: 478 PPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRL 537
             G Y+LVP+ F+  +  +F +R+FSE     +      E  L+   +S  ++  G+ ++
Sbjct: 463 KKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLR------ELTLDMPKMSCWNLARGYPKV 516

Query: 538 FAQLAGEDAE 547
             Q+    AE
Sbjct: 517 VTQITVHSAE 526


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score =  234 bits (598), Expect = 2e-61
 Identities = 118/297 (39%), Positives = 181/297 (60%), Gaps = 48/297 (16%)

Query: 447 HLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKK 506
           HL K+FFL N ++ RS T+IN+REV  RF+LPP EY++VPST+EP+++G+F +RVFSEK+
Sbjct: 7   HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 66

Query: 507 ADYQAVDDEIEANL--------------------EEFDIS-------------------- 526
              + V++ I  +                     +E  +                     
Sbjct: 67  NLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQ 126

Query: 527 --------EDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCK 578
                   E +    FR +F Q+AG+D EI A EL+ +L  V+ K +D+K+ GF++E+C+
Sbjct: 127 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCR 186

Query: 579 IMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKM 638
            M+ ++D+DGSGKL L+EF+ LW KI+ +QKI++  D D+SGT+NSYEMR A+ +AGF +
Sbjct: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246

Query: 639 PCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695
             QL+ +I  R+AD  + IDFD+F+ C VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 303


>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score =  220 bits (561), Expect = 3e-57
 Identities = 156/509 (30%), Positives = 230/509 (45%), Gaps = 60/509 (11%)

Query: 42  AGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGA 101
           A  LF+D +FPA  S+L      P +     I W+RP EICA P+          + QG 
Sbjct: 10  ARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGL 69

Query: 102 LGDCWLLAAIASLTLNEEILARVVPLNQSF--QENYAGIFHFQFWQYGEWVEVVVDDRLP 159
           LGDCW L A A+L  +  +L +V+P  Q     + Y G F  + WQ+G WVEV  DDRLP
Sbjct: 70  LGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLP 129

Query: 160 TKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELK- 218
              G L F        FW  LLEK YAK++G YE L  G   +   D TGG+AE + LK 
Sbjct: 130 CLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKG 189

Query: 219 ---------KPPPNLFKIIQKA--LQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVT 267
                    +P     +  ++   L+   L+ C +    A   E   F      HA+ V+
Sbjct: 190 VAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEF------HAFIVS 243

Query: 268 GAEEVESN-GSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWM 326
              E++   G    L+RI+NPWG   W G W +    W+ +D      L  + ++GEFW+
Sbjct: 244 DLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWV 303

Query: 327 SFSDFLRHYSRLEI-CNLTPDTLTSDTYKKWKL---TKMDGNWRRGSTAGGCRNYPNTFW 382
              +FLR +  L +   +T        Y +  L     + G W +G +AGGCRN  + F 
Sbjct: 304 EEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFP 362

Query: 383 MNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHR-------RRQRKMGEDMHTIGFGIYE 435
            NP++ +++ E  E            + ++Q+ R        R R +  D HT  +    
Sbjct: 363 SNPKFWLRVSEPSE----------VYIAVLQRSRLHAADWAGRARALVGDSHT-SWSPAS 411

Query: 436 VPEELSGQTNIHLSKNFFLTNRARERSDTFINL------------REVLNRFKLPPGEYI 483
           +P +      +HL K      + R      +++            REV  R +L PG Y+
Sbjct: 412 IPGKHYQAVGLHLWK----VEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYL 467

Query: 484 LVPSTFEPNKDGDFCIRVFSEKKADYQAV 512
            VPSTF  +  G+F +RVFS  +    A+
Sbjct: 468 AVPSTFLKDAPGEFLLRVFSTGRVSLSAI 496



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 43/147 (29%), Positives = 64/147 (43%), Gaps = 17/147 (11%)

Query: 355 KWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQK 414
           +W   ++ G+WR G TAGG RN+  ++  NP +   + E       G       + L Q 
Sbjct: 513 EWGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSVPE-------GPGPRCVRITLHQ- 563

Query: 415 HRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNR 474
                R    + H IGF I++VPE    Q    L     L +    R       +EV   
Sbjct: 564 ---HCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHR-----YAQEVSRL 615

Query: 475 FKLPPGEYILVPSTFEPNKDGDFCIRV 501
             LP G Y +VPST+ P+ +G F + +
Sbjct: 616 CLLPAGTYKVVPSTYLPDTEGAFTVTI 642


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  211 bits (536), Expect = 2e-54
 Identities = 152/500 (30%), Positives = 223/500 (44%), Gaps = 62/500 (12%)

Query: 42  AGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGA 101
           A  LF+D +FPA  S+L      P +     I W+RP EICA P+          + QG 
Sbjct: 10  ARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGL 69

Query: 102 LGDCWLLAAIASLTLNEEILARVVPLNQSF--QENYAGIFHFQFWQYGEWVEVVVDDRLP 159
           LGDCW L A A+L  +  +L +V+P  Q     + Y G F  + WQ+G WVEV  DDRLP
Sbjct: 70  LGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLP 129

Query: 160 TKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELK- 218
              G L F        FW  LLEK YAK++G YE L  G   +   D TGG+AE + LK 
Sbjct: 130 CLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKG 189

Query: 219 ---------KPPPNLFKIIQKA--LQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVT 267
                    +P     +  ++   L+   L+ C +    A   E   F      HA+ V+
Sbjct: 190 VAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEF------HAFIVS 243

Query: 268 GAEEVESN-GSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWM 326
              E++   G    L+RI+NPWG   W G W +    W+ +D      L  + ++GEFW+
Sbjct: 244 DLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWV 303

Query: 327 SFSDFLRHYSRLEI-CNLTPDTLTSDTYKKWKL---TKMDGNWRRGSTAGGCRNYPNTFW 382
              +FLR +  L +   +T        Y +  L     + G W +G +AGGCRN  + F 
Sbjct: 304 EEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFP 362

Query: 383 MNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHR-------RRQRKMGEDMHT------- 428
            NP++ +++ E  E            + ++Q+ R        R R +  D HT       
Sbjct: 363 SNPKFWLRVSEPSE----------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASI 412

Query: 429 -------IGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGE 481
                  +G  +++VPE    Q    L     L +    R       +EV     LP G 
Sbjct: 413 PGKHYQAVGLHLWKVPEGGRSQDAPPLLLQEPLLSCVPHR-----YAQEVSRLCLLPAGT 467

Query: 482 YILVPSTFEPNKDGDFCIRV 501
           Y +VPST+ P+ +G F + +
Sbjct: 468 YKVVPSTYLPDTEGAFTVTI 487


>gi|4502565 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  180 bits (457), Expect = 3e-45
 Identities = 87/197 (44%), Positives = 128/197 (64%)

Query: 499 IRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR 558
           I   SE  A Y         +    + +E +    FRRLFAQLAG+D E+SA EL  IL 
Sbjct: 66  ISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILN 125

Query: 559 RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR 618
           +V+ +  D+K+DGF I+TC+ MV ++DSD +GKLG +EF  LW  I+++Q IY++ D DR
Sbjct: 126 KVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDR 185

Query: 619 SGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQ 678
           SGT+ S E+  A E AGF +   L+ +I+ R++D+   +DFDNF+ CLVRL+ +F+ FK 
Sbjct: 186 SGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKS 245

Query: 679 LDPENTGTIELDLISWL 695
           LD + TG I++++  WL
Sbjct: 246 LDKDGTGQIQVNIQEWL 262


>gi|51599151 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  180 bits (457), Expect = 3e-45
 Identities = 87/197 (44%), Positives = 128/197 (64%)

Query: 499 IRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR 558
           I   SE  A Y         +    + +E +    FRRLFAQLAG+D E+SA EL  IL 
Sbjct: 66  ISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILN 125

Query: 559 RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR 618
           +V+ +  D+K+DGF I+TC+ MV ++DSD +GKLG +EF  LW  I+++Q IY++ D DR
Sbjct: 126 KVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDR 185

Query: 619 SGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQ 678
           SGT+ S E+  A E AGF +   L+ +I+ R++D+   +DFDNF+ CLVRL+ +F+ FK 
Sbjct: 186 SGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKS 245

Query: 679 LDPENTGTIELDLISWL 695
           LD + TG I++++  WL
Sbjct: 246 LDKDGTGQIQVNIQEWL 262


>gi|14161692 calpain small subunit 2 [Homo sapiens]
          Length = 248

 Score =  170 bits (430), Expect = 5e-42
 Identities = 80/189 (42%), Positives = 127/189 (67%)

Query: 507 ADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQD 566
           A Y       + +    + SE +    FR+ F QLAG D E+ A +L  IL +VL+K +D
Sbjct: 54  AQYTPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKD 113

Query: 567 IKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYE 626
           +K+DGFS++TC+ +V ++DSD +GKLG +EF  LW  I+K+Q +Y++ D D SG++ S +
Sbjct: 114 LKTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQ 173

Query: 627 MRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGT 686
           +R AL+ AGF++  QL+Q+IV R+A++   +DF+NF+ CLVRL+ +F+ FK LD +  G 
Sbjct: 174 LRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGL 233

Query: 687 IELDLISWL 695
           I++ +  WL
Sbjct: 234 IQVSIKEWL 242


>gi|27765080 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  159 bits (402), Expect = 8e-39
 Identities = 71/149 (47%), Positives = 109/149 (73%)

Query: 547 EISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQK 606
           EI A EL+ +L  V+ K +D+K+ GF++E+C+ M+ ++D+DGSGKL L+EF+ LW KI+ 
Sbjct: 2   EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 61

Query: 607 YQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCL 666
           +QKI++  D D+SGT+NSYEMR A+ +AGF +  QL+ +I  R+AD  + IDFD+F+ C 
Sbjct: 62  WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 121

Query: 667 VRLETLFKIFKQLDPENTGTIELDLISWL 695
           VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 122 VRLEGMFRAFHAFDKDGDGIIKLNVLEWL 150


>gi|27765078 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  159 bits (402), Expect = 8e-39
 Identities = 71/149 (47%), Positives = 109/149 (73%)

Query: 547 EISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQK 606
           EI A EL+ +L  V+ K +D+K+ GF++E+C+ M+ ++D+DGSGKL L+EF+ LW KI+ 
Sbjct: 2   EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 61

Query: 607 YQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCL 666
           +QKI++  D D+SGT+NSYEMR A+ +AGF +  QL+ +I  R+AD  + IDFD+F+ C 
Sbjct: 62  WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 121

Query: 667 VRLETLFKIFKQLDPENTGTIELDLISWL 695
           VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 122 VRLEGMFRAFHAFDKDGDGIIKLNVLEWL 150


>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score =  151 bits (382), Expect = 2e-36
 Identities = 98/326 (30%), Positives = 144/326 (44%), Gaps = 29/326 (8%)

Query: 39  CLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICAD-------PQFIIGG 91
           C E    F D SFP  P ++GF        + R  +W RP EI             +   
Sbjct: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVR--QWLRPQEINCSVFRDHRATWSVFHT 538

Query: 92  ATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVE 151
              +DI QG LG+CW L+A+A L    +++ RV+       E   G +  +  + G W  
Sbjct: 539 LRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQVRLCKDGTWTT 595

Query: 152 VVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGI 211
           V+VDD LP  +   L    A+  + W AL+EKA AK++G Y AL  G   EG    TG  
Sbjct: 596 VLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAP 655

Query: 212 AEWYELKKPPPN----------LFKIIQKALQKGSLLGCSI-DITSAADSEAITFQKLVK 260
            E   L+    N          ++  +  + + G L+G S        D  A     L  
Sbjct: 656 CESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRP 715

Query: 261 GHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHE 320
            HAYS+    +V+      +L+R+RNPWG   W G W+D  P W        E +     
Sbjct: 716 RHAYSILDVRDVQGT----RLLRLRNPWGRFSWNGSWSDEWPHWP--GHLRGELMPHGSS 769

Query: 321 DGEFWMSFSDFLRHYSRLEICNLTPD 346
           +G FWM + DF+R++  ++IC +  D
Sbjct: 770 EGVFWMEYGDFVRYFDSVDICKVHSD 795


>gi|38679884 sorcin isoform b [Homo sapiens]
          Length = 183

 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 55/153 (35%), Positives = 85/153 (55%), Gaps = 10/153 (6%)

Query: 538 FAQLAGEDAEISAFELQTILRRVLAKRQDIKSDG---FSIETCKIMVDMLDSDGSGKLGL 594
           FA +AG+D +I A ELQ  L       Q   + G   F++ETC++MV MLD D SG +G 
Sbjct: 24  FAAVAGQDGQIDADELQRCLT------QSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGF 77

Query: 595 KEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQ 654
            EF  LW  +  +++ +   D DRSGT++  E++KAL   GF++  Q    I  R++ + 
Sbjct: 78  NEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNG 137

Query: 655 LIIDFDNFVRCLVRLETLFKIFKQLDPENTGTI 687
             I FD+++ C V+L  L   F++ D    G +
Sbjct: 138 K-ITFDDYIACCVKLRALTDSFRRRDTAQQGVV 169


>gi|4507207 sorcin isoform a [Homo sapiens]
          Length = 198

 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 55/153 (35%), Positives = 85/153 (55%), Gaps = 10/153 (6%)

Query: 538 FAQLAGEDAEISAFELQTILRRVLAKRQDIKSDG---FSIETCKIMVDMLDSDGSGKLGL 594
           FA +AG+D +I A ELQ  L       Q   + G   F++ETC++MV MLD D SG +G 
Sbjct: 39  FAAVAGQDGQIDADELQRCLT------QSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGF 92

Query: 595 KEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQ 654
            EF  LW  +  +++ +   D DRSGT++  E++KAL   GF++  Q    I  R++ + 
Sbjct: 93  NEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNG 152

Query: 655 LIIDFDNFVRCLVRLETLFKIFKQLDPENTGTI 687
             I FD+++ C V+L  L   F++ D    G +
Sbjct: 153 K-ITFDDYIACCVKLRALTDSFRRRDTAQQGVV 184


>gi|7656959 calpain 7 [Homo sapiens]
          Length = 813

 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 78/290 (26%), Positives = 135/290 (46%), Gaps = 36/290 (12%)

Query: 69  KTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIA-----SLTLNEEILAR 123
           KT   +W RP ++  +P  I    +   I Q  + DC  +A++A         N++++  
Sbjct: 255 KTTFSKWVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITG 313

Query: 124 VV-PLNQSFQENY--AGIFHFQFWQYGEWVEVVVDDRLPTKD-GELLFVHSAEGSEFWSA 179
           ++ P N+  +  Y   G +  +    G   +V++DD+LP    GELL  +S   SE W +
Sbjct: 314 IIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVS 373

Query: 180 LLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKK-----PPPNLFKIIQKALQK 234
           L+EKAY K+ G Y+   G  +       TG I E   +          N F+++ +   K
Sbjct: 374 LIEKAYMKVMGGYD-FPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHK 432

Query: 235 GS-LLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEW 293
           G  L+  S  + + A+ E      LV  HAY+V    E +      + I+++NPW  + W
Sbjct: 433 GDVLITASTGMMTEAEGEK---WGLVPTHAYAVLDIREFKG----LRFIQLKNPWSHLRW 485

Query: 294 TGRWNDN-CPSWN-------TIDPEERERLTRRHEDGEFWMSFSDFLRHY 335
            GR+++N   +W          DP    R  ++ ++G FW+S+ D  ++Y
Sbjct: 486 KGRYSENDVKNWTPELQKYLNFDP----RTAQKIDNGIFWISWDDLCQYY 531



 Score = 34.3 bits (77), Expect = 0.40
 Identities = 36/138 (26%), Positives = 57/138 (41%), Gaps = 31/138 (22%)

Query: 360 KMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQ 419
           +++G W  G +AGGC N+  T   NP Y   +E+              L+ L        
Sbjct: 691 RINGKWS-GQSAGGCGNFQETHKNNPIYQFHIEKTG----------PLLIEL-------- 731

Query: 420 RKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPP 479
              G   +++GF +  V     G    H     FL   + +    F  L E+ N   +P 
Sbjct: 732 --RGPRQYSVGFEVVTV--STLGDPGPH----GFLRKSSGDYRCGFCYL-ELEN---IPS 779

Query: 480 GEYILVPSTFEPNKDGDF 497
           G + ++PSTF P ++G F
Sbjct: 780 GIFNIIPSTFLPKQEGPF 797


>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
           sapiens]
          Length = 217

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 52/155 (33%), Positives = 86/155 (55%), Gaps = 4/155 (2%)

Query: 532 DGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGK 591
           D     F+ +AG+D E+ A ELQ  L +      +     FS+ETC+IM+ MLD D +GK
Sbjct: 52  DSVYTYFSAVAGQDGEVDAEELQRCLTQ---SGINGTYSPFSLETCRIMIAMLDRDHTGK 108

Query: 592 LGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFA 651
           +G   F  LW  +  +++ +  +D D SGT+  +E+R+A+   G+++  Q    IV R++
Sbjct: 109 MGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYS 168

Query: 652 DDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGT 686
            +  I  FD++V C V+L  L   F++ D    G+
Sbjct: 169 KNGRIF-FDDYVACCVKLRALTDFFRKRDHLQQGS 202


>gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]
          Length = 284

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 36/120 (30%), Positives = 71/120 (59%), Gaps = 2/120 (1%)

Query: 572 FSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKAL 631
           F+ ETC +M++M D   SG++ +  F  LW  IQ+++ ++++ D DRSG+++  E+++AL
Sbjct: 151 FNDETCLMMINMFDKTKSGRIDVYGFSALWKFIQQWKNLFQQYDRDRSGSISYTELQQAL 210

Query: 632 EEAGFKMPCQLHQVIVARFADDQL--IIDFDNFVRCLVRLETLFKIFKQLDPENTGTIEL 689
            + G+ +  Q  Q++V+R+        +  D F++   +L+ L + F++ D    G I L
Sbjct: 211 SQMGYNLSPQFTQLLVSRYCPRSANPAMQLDRFIQVCTQLQVLTEAFREKDTAVQGNIRL 270


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,568,125
Number of Sequences: 37866
Number of extensions: 1272964
Number of successful extensions: 4351
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 4162
Number of HSP's gapped (non-prelim): 121
length of query: 700
length of database: 18,247,518
effective HSP length: 109
effective length of query: 591
effective length of database: 14,120,124
effective search space: 8344993284
effective search space used: 8344993284
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.