Search of human proteins with 7705383

Search of human proteins with 7705383

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7705383 calpain 9 isoform 2 [Homo sapiens]
         (664 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7705383 calpain 9 isoform 2 [Homo sapiens]                        1357   0.0  
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                        1340   0.0  
gi|27765074 calpain 3 isoform c [Homo sapiens]                        779   0.0  
gi|27765072 calpain 3 isoform b [Homo sapiens]                        745   0.0  
gi|4557405 calpain 3 isoform a [Homo sapiens]                         741   0.0  
gi|12408656 calpain 1, large subunit [Homo sapiens]                   712   0.0  
gi|47078247 calpain 3 isoform f [Homo sapiens]                        695   0.0  
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       687   0.0  
gi|221554549 calpain 8 [Homo sapiens]                                 684   0.0  
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       651   0.0  
gi|215490104 calpain 11 [Homo sapiens]                                628   e-180
gi|38707981 calpain 12 [Homo sapiens]                                 455   e-128
gi|223468608 calpain 14 [Homo sapiens]                                435   e-122
gi|37577157 calpain 5 [Homo sapiens]                                  316   5e-86
gi|41152101 calpain 13 [Homo sapiens]                                 276   4e-74
gi|27765076 calpain 3 isoform d [Homo sapiens]                        270   4e-72
gi|13186316 calpain 6 [Homo sapiens]                                  258   1e-68
gi|13186302 calpain 10 isoform a [Homo sapiens]                       174   2e-43
gi|89353291 calpain 10 isoform c [Homo sapiens]                       167   3e-41
gi|14161692 calpain small subunit 2 [Homo sapiens]                    166   8e-41
gi|4502565 calpain, small subunit 1 [Homo sapiens]                    165   1e-40
gi|51599151 calpain, small subunit 1 [Homo sapiens]                   165   1e-40
gi|27765080 calpain 3 isoform e [Homo sapiens]                        150   3e-36
gi|27765078 calpain 3 isoform e [Homo sapiens]                        150   3e-36
gi|5032105 small optic lobes [Homo sapiens]                           126   7e-29
gi|38679884 sorcin isoform b [Homo sapiens]                            94   3e-19
gi|4507207 sorcin isoform a [Homo sapiens]                             94   3e-19
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap...    89   1e-17
gi|7656959 calpain 7 [Homo sapiens]                                    82   1e-15
gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]            74   6e-13

>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score = 1357 bits (3511), Expect = 0.0
 Identities = 664/664 (100%), Positives = 664/664 (100%)

Query: 1   MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60
           MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER
Sbjct: 1   MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60

Query: 61  PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120
           PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD
Sbjct: 61  PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120

Query: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180
           QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL
Sbjct: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180

Query: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240
           NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA
Sbjct: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240

Query: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDRMAFKDFKA 300
           ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDRMAFKDFKA
Sbjct: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDRMAFKDFKA 300

Query: 301 HFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTE 360
           HFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTE
Sbjct: 301 HFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTE 360

Query: 361 KDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARS 420
           KDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARS
Sbjct: 361 KDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARS 420

Query: 421 KTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPE 480
           KTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPE
Sbjct: 421 KTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPE 480

Query: 481 PPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISC 540
           PPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISC
Sbjct: 481 PPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISC 540

Query: 541 KNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQ 600
           KNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQ
Sbjct: 541 KNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQ 600

Query: 601 LSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHL 660
           LSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHL
Sbjct: 601 LSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHL 660

Query: 661 TMNI 664
           TMNI
Sbjct: 661 TMNI 664


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score = 1340 bits (3468), Expect = 0.0
 Identities = 663/690 (96%), Positives = 663/690 (96%), Gaps = 26/690 (3%)

Query: 1   MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60
           MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER
Sbjct: 1   MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60

Query: 61  PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120
           PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD
Sbjct: 61  PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120

Query: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180
           QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL
Sbjct: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180

Query: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240
           NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA
Sbjct: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240

Query: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------- 292
           ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSD         
Sbjct: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVG 300

Query: 293 ------------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR 334
                             MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR
Sbjct: 301 PAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR 360

Query: 335 GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY 394
           GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY
Sbjct: 361 GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY 420

Query: 395 AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD 454
           AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD
Sbjct: 421 AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD 480

Query: 455 FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE 514
           FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE
Sbjct: 481 FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE 540

Query: 515 ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF 574
           ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF
Sbjct: 541 ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF 600

Query: 575 LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN 634
           LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN
Sbjct: 601 LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN 660

Query: 635 ASRVFQALSTKNKEFIHLNINEFIHLTMNI 664
           ASRVFQALSTKNKEFIHLNINEFIHLTMNI
Sbjct: 661 ASRVFQALSTKNKEFIHLNINEFIHLTMNI 690


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score =  779 bits (2012), Expect = 0.0
 Identities = 376/713 (52%), Positives = 504/713 (70%), Gaps = 59/713 (8%)

Query: 6   RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43
           R+PGP  HP    A  T + G                      ++FEQ+ ++CL++  L+
Sbjct: 18  RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75

Query: 44  EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103
            D +FP   +SLFYS++  I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 76  VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135

Query: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163
           A LTLNQ  L RVIP DQSF   YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S 
Sbjct: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195

Query: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223
             NEFWSALLEKAYAKL+GSYEALKGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255

Query: 224 LKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQV 283
           ++RGSL+GC IDT    + E R   GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQV
Sbjct: 256 IERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQV 315

Query: 284 EWNGSWSDR--------------------------MAFKDFKAHFDKVEICNLTPDALEE 317
           EWNGSWSDR                          M+++DF  HF K+EICNLT DAL+ 
Sbjct: 316 EWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQS 375

Query: 318 DAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVA 373
           D +  W V+V++G WVRG +AGGCRNF DTFWTNPQ +L L E+D+  ++    CSFLVA
Sbjct: 376 DKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVA 435

Query: 374 LMQKDRRKLKRFGANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREV 429
           LMQK+RRK ++ GA++ TIG+AIYE P +     +HL KDFF Y+AS+ARSKT+IN+REV
Sbjct: 436 LMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREV 495

Query: 430 SDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQ 489
           S RF+LPP EY+++PST+EPHQE +F LR+FSEK+ ++ +++  + +D P  P+P   DQ
Sbjct: 496 SQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRP-VPQPGSSDQ 554

Query: 490 ETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDT 549
           E+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMDT
Sbjct: 555 ESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDT 614

Query: 550 SGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLI 609
            G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +I
Sbjct: 615 DGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDII 674

Query: 610 VLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 662
            +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ LTM
Sbjct: 675 TMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 727


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score =  745 bits (1924), Expect = 0.0
 Identities = 377/798 (47%), Positives = 505/798 (63%), Gaps = 143/798 (17%)

Query: 6   RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43
           R+PGP  HP    A  T + G                      ++FEQ+ ++CL++  L+
Sbjct: 18  RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75

Query: 44  EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103
            D +FP   +SLFYS++  I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 76  VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135

Query: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163
           A LTLNQ  L RVIP DQSF   YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S 
Sbjct: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195

Query: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223
             NEFWSALLEKAYAKL+GSYEALKGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255

Query: 224 LKRGSLLGCFID------------------------------------------------ 235
           ++RGSL+GC ID                                                
Sbjct: 256 IERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTR 315

Query: 236 TRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR--- 292
           T    + E R   GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQVEWNGSWSDR   
Sbjct: 316 TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKD 375

Query: 293 -----------------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ 329
                                  M+++DF  HF K+EICNLT DAL+ D +  W V+V++
Sbjct: 376 WSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNE 435

Query: 330 GSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRF 385
           G WVRG +AGGCRNF DTFWTNPQ +L L E+D+  ++    CSFLVALMQK+RRK ++ 
Sbjct: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495

Query: 386 GANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 441
           GA++ TIG+AIYE P +     +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+
Sbjct: 496 GASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYV 555

Query: 442 LIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEP-------------------- 481
           ++PST+EPHQE +F LR+FSEK+ ++ +++  + +D P P                    
Sbjct: 556 IVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQES 615

Query: 482 -----------------PKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 524
                            P+P   DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+
Sbjct: 616 EEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVV 675

Query: 525 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 584
            K KD+K    +L SC+++I+LMDT G+GKL   EF   W+K+K W  +F  +D D+SGT
Sbjct: 676 NKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGT 735

Query: 585 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 644
           +++YE+R A+  AGF L++ L  +I +RYAD+ + +DFD F+ C VRLE   R F A   
Sbjct: 736 INSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDK 795

Query: 645 KNKEFIHLNINEFIHLTM 662
                I LN+ E++ LTM
Sbjct: 796 DGDGIIKLNVLEWLQLTM 813


>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score =  741 bits (1913), Expect = 0.0
 Identities = 377/804 (46%), Positives = 504/804 (62%), Gaps = 149/804 (18%)

Query: 6   RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43
           R+PGP  HP    A  T + G                      ++FEQ+ ++CL++  L+
Sbjct: 18  RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75

Query: 44  EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103
            D +FP   +SLFYS++  I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 76  VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135

Query: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163
           A LTLNQ  L RVIP DQSF   YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S 
Sbjct: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195

Query: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223
             NEFWSALLEKAYAKL+GSYEALKGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255

Query: 224 LKRGSLLGCFID------------------------------------------------ 235
           ++RGSL+GC ID                                                
Sbjct: 256 IERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTR 315

Query: 236 TRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR--- 292
           T    + E R   GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQVEWNGSWSDR   
Sbjct: 316 TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKD 375

Query: 293 -----------------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ 329
                                  M+++DF  HF K+EICNLT DAL+ D +  W V+V++
Sbjct: 376 WSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNE 435

Query: 330 GSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRF 385
           G WVRG +AGGCRNF DTFWTNPQ +L L E+D+  ++    CSFLVALMQK+RRK ++ 
Sbjct: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495

Query: 386 GANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 441
           GA++ TIG+AIYE P +     +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+
Sbjct: 496 GASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYV 555

Query: 442 LIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPP-------------- 487
           ++PST+EPHQE +F LR+FSEK+ ++ +++  + +D P   K T P              
Sbjct: 556 IVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKEL 615

Query: 488 -----------------------------DQETEEEQRFRALFEQVAGEDMEVTAEELEY 518
                                        DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ 
Sbjct: 616 GVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKK 675

Query: 519 VLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFD 578
           VLN V+ K KD+K    +L SC+++I+LMDT G+GKL   EF   W+K+K W  +F  +D
Sbjct: 676 VLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYD 735

Query: 579 ADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRV 638
            D+SGT+++YE+R A+  AGF L++ L  +I +RYAD+ + +DFD F+ C VRLE   R 
Sbjct: 736 TDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRA 795

Query: 639 FQALSTKNKEFIHLNINEFIHLTM 662
           F A        I LN+ E++ LTM
Sbjct: 796 FHAFDKDGDGIIKLNVLEWLQLTM 819


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  712 bits (1838), Expect = 0.0
 Identities = 355/678 (52%), Positives = 470/678 (69%), Gaps = 45/678 (6%)

Query: 26  GQSFEQMRQECLQRGTLFEDADFPASNSSLFYSE-----RPQIPFVWKRPGEIVKNPEFI 80
           GQ +EQ+R  CLQ GTLF D  FP    SL Y +            WKRP E++ NP+FI
Sbjct: 39  GQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFI 98

Query: 81  LGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSE 140
           + GATRTDICQG LGDCWLLAAIASLTLN   L RV+P  QSF  GYAGIFHFQ WQ  E
Sbjct: 99  VDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGE 158

Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
           W+DVV+DD LP    +LVF+HSA+ NEFWSALLEKAYAK+NGSYEAL GGS  E  EDFT
Sbjct: 159 WVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFT 218

Query: 201 GGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260
           GGV E ++ ++AP + Y+I+ KAL+RGSLLGC ID  S  + EA T   L+KGHAYSVTG
Sbjct: 219 GGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTG 278

Query: 261 IDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAF 295
             QV++RGQ + LIR+RNPWG+VEW G+WSD                          M+F
Sbjct: 279 AKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSF 338

Query: 296 KDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIK 355
           +DF   F ++EICNLTPDAL+   I KW  T+++G+W RGSTAGGCRN+  TFW NPQ K
Sbjct: 339 RDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFK 398

Query: 356 LSLTEKDE----GQEE--CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----DE 404
           + L E D+    G  E  CSF++ALMQK RR+ +RFG ++ TIG+A+YE P +       
Sbjct: 399 IRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAV 458

Query: 405 HLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKK 464
           HL +DFF  +ASRARS+ FINLREVS RF+LPPGEY+++PSTFEP++E DF LR FSEK 
Sbjct: 459 HLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKS 518

Query: 465 AITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 524
           A T ++D  +  +LP+    +    E E ++ F+ALF Q+AGEDME++ +EL  +LN ++
Sbjct: 519 AGTVELDDQIQANLPDEQVLS----EEEIDENFKALFRQLAGEDMEISVKELRTILNRII 574

Query: 525 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 584
            K KD++ K  SL SC+++++LMD  GNGKL   EF + W++++ ++++F +FD DKSG+
Sbjct: 575 SKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGS 634

Query: 585 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 644
           MS YE+R A+++AGF+L+  L +LI+ RY++ +L +DFD+F+ CLVRLE   R F+ L T
Sbjct: 635 MSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDT 694

Query: 645 KNKEFIHLNINEFIHLTM 662
                +  ++ +++ LTM
Sbjct: 695 DLDGVVTFDLFKWLQLTM 712


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score =  695 bits (1794), Expect = 0.0
 Identities = 347/714 (48%), Positives = 463/714 (64%), Gaps = 119/714 (16%)

Query: 68  KRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGY 127
           ++  EI +NP FI+ GA RTDICQGELGDCW LAAIA LTLNQ  L RVIP DQSF   Y
Sbjct: 13  QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY 72

Query: 128 AGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEAL 187
           AGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S   NEFWSALLEKAYAKL+GSYEAL
Sbjct: 73  AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEAL 132

Query: 188 KGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFID------------ 235
           KGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA++RGSL+GC ID            
Sbjct: 133 KGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPS 192

Query: 236 ------------------------------------TRSAAESEARTPFGLIKGHAYSVT 259
                                               T    + E R   GL++GHAYSVT
Sbjct: 193 GLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVT 252

Query: 260 GIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR--------------------------M 293
           G+D+V F+G++++L+R+RNPWGQVEWNGSWSDR                          M
Sbjct: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312

Query: 294 AFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQ 353
           +++DF  HF K+EICNLT DAL+ D +  W V+V++G WVRG +AGGCRNF DTFWTNPQ
Sbjct: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQ 372

Query: 354 IKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK----DEH 405
            +L L E+D+  ++    CSFLVALMQK+RRK ++ GA++ TIG+AIYE P +     +H
Sbjct: 373 YRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQH 432

Query: 406 LNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKA 465
           L KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+++PST+EPHQE +F LR+FSEK+ 
Sbjct: 433 LQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRN 492

Query: 466 ITRDMDGNVDIDLPEP-------------------------------------PKPTPPD 488
           ++ +++  + +D P P                                     P+P   D
Sbjct: 493 LSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSD 552

Query: 489 QETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMD 548
           QE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMD
Sbjct: 553 QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMD 612

Query: 549 TSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQL 608
           T G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +
Sbjct: 613 TDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDI 672

Query: 609 IVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 662
           I +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ LTM
Sbjct: 673 ITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 726


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  687 bits (1774), Expect = 0.0
 Identities = 340/667 (50%), Positives = 464/667 (69%), Gaps = 44/667 (6%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIP-----FVWKRPGEIVKNPEFIL 81
           Q +E +R ECL+ GTLF+D  FPA  S+L + E            WKRP EI  +P+FI+
Sbjct: 30  QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFII 89

Query: 82  GGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEW 141
           GGATRTDICQG LGDCWLLAAIASLTLN++ LARV+P +QSF   YAGIFHFQFWQ+ EW
Sbjct: 90  GGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEW 149

Query: 142 LDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
           ++VV+DDRLPT    L+F+HSA+ +EFWSALLEKAYAK+NG YEAL GG+  E  EDFTG
Sbjct: 150 VEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTG 209

Query: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGI 261
           G+AE ++ K+ P N ++I++KAL++GSLLGC ID  SAA+SEA T   L+KGHAYSVTG 
Sbjct: 210 GIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGA 269

Query: 262 DQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFK 296
           ++V   G   +LIRIRNPWG+VEW G W+D                          M+F 
Sbjct: 270 EEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSFS 329

Query: 297 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKL 356
           DF  H+ ++EICNLTPD L  D   KW++T   G+W RGSTAGGCRN+ +TFW NPQ  +
Sbjct: 330 DFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLI 389

Query: 357 SLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----DEHLN 407
            L E+DE +E+    C+FLV L+QK RR+ ++ G ++ TIG+ IYE P++     + HL+
Sbjct: 390 KLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLS 449

Query: 408 KDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAIT 467
           K+FF  + +R RS TFINLREV +RFKLPPGEYIL+PSTFEP+++ DFC+R+FSEKKA  
Sbjct: 450 KNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADY 509

Query: 468 RDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKK 527
           + +D  ++ +L E         E + +  FR LF Q+AGED E++A EL+ +L  VL K+
Sbjct: 510 QAVDDEIEANLEE-----FDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKR 564

Query: 528 KDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMST 587
           +DIK    S+ +CK ++ ++D+ G+GKL   EF + W K++++  ++   D D+SGTM++
Sbjct: 565 QDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNS 624

Query: 588 YELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNK 647
           YE+R AL+ AGF++   L Q+IV R+AD++L +DFD+F+ CLVRLE   ++F+ L  +N 
Sbjct: 625 YEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENT 684

Query: 648 EFIHLNI 654
             I L++
Sbjct: 685 GTIELDL 691


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  684 bits (1766), Expect = 0.0
 Identities = 338/674 (50%), Positives = 460/674 (68%), Gaps = 45/674 (6%)

Query: 26  GQSFEQMRQECLQRGTLFEDADFPASNSSLFYSE----RPQIP-FVWKRPGEIVKNPEFI 80
           GQ F+ +RQ+CL  G LF+D +FPA  S+L Y +     PQ    +WKRP E+  +P+FI
Sbjct: 29  GQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFI 88

Query: 81  LGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSE 140
           +GGATRTDICQG LGDCWLLAAIASLTLN++ L RV+P+DQ F   YAGIFHFQFWQ+ E
Sbjct: 89  VGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGE 148

Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
           W++VVIDDRLPT   +L+FLHS   NEFWSALLEKAYAKLNG YEAL GGS +E  EDFT
Sbjct: 149 WVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFT 208

Query: 201 GGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260
           GG++E +  K+ P N Y+I+ KAL  GSLLGC ID  SAAE+EA T   L+K HAYSVTG
Sbjct: 209 GGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTG 268

Query: 261 IDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAF 295
           +++V+F+G   +LIR+RNPWG+VEW+G+WSD                          M+ 
Sbjct: 269 VEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSL 328

Query: 296 KDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIK 355
            DF   F ++EICNL+PD+L  + +HKW + +  G W RGSTAGGC+N+  T+WTNPQ K
Sbjct: 329 SDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFK 388

Query: 356 LSLTEKDEGQEE------CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----DE 404
           + L E DE QEE      C+ L+ LMQK+RR  KR G  +L+IGYA+Y+ P +     D 
Sbjct: 389 IRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDA 448

Query: 405 HLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKK 464
           HL +DFF  +   AR+ T++NLREVS R +LPPGEY+++PSTFEP ++ +FCLR+FSEKK
Sbjct: 449 HLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKK 508

Query: 465 AITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 524
           A   ++ G+V    P  P P+  DQ   E+ +FR LFE++AG+D E+TA  L+ +LN   
Sbjct: 509 AQALEI-GDVVAGNPYEPHPSEVDQ---EDDQFRRLFEKLAGKDSEITANALKILLNEAF 564

Query: 525 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 584
            K+ DIKF   ++ +C+ +ISL+D++G G L   EFK  W K+++++ ++   D + SGT
Sbjct: 565 SKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGT 624

Query: 585 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 644
           +  +E+RTAL+ AGF L+S + Q I LRYA  +L ++FD F+ C++RLE   ++F  L  
Sbjct: 625 IDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDE 684

Query: 645 KNKEFIHLNINEFI 658
                + L++ E++
Sbjct: 685 DKDGMVQLSLAEWL 698


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  651 bits (1680), Expect = 0.0
 Identities = 319/617 (51%), Positives = 437/617 (70%), Gaps = 39/617 (6%)

Query: 72  EIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIF 131
           EI  +P+FI+GGATRTDICQG LGDCWLLAAIASLTLN++ LARV+P +QSF   YAGIF
Sbjct: 2   EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61

Query: 132 HFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGS 191
           HFQFWQ+ EW++VV+DDRLPT    L+F+HSA+ +EFWSALLEKAYAK+NG YEAL GG+
Sbjct: 62  HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121

Query: 192 AIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLI 251
             E  EDFTGG+AE ++ K+ P N ++I++KAL++GSLLGC ID  SAA+SEA T   L+
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181

Query: 252 KGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR------------------- 292
           KGHAYSVTG ++V   G   +LIRIRNPWG+VEW G W+D                    
Sbjct: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241

Query: 293 ------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLD 346
                 M+F DF  H+ ++EICNLTPD L  D   KW++T   G+W RGSTAGGCRN+ +
Sbjct: 242 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301

Query: 347 TFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK 402
           TFW NPQ  + L E+DE +E+    C+FLV L+QK RR+ ++ G ++ TIG+ IYE P++
Sbjct: 302 TFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEE 361

Query: 403 -----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCL 457
                + HL+K+FF  + +R RS TFINLREV +RFKLPPGEYIL+PSTFEP+++ DFC+
Sbjct: 362 LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCI 421

Query: 458 RIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELE 517
           R+FSEKKA  + +D  ++ +L E         E + +  FR LF Q+AGED E++A EL+
Sbjct: 422 RVFSEKKADYQAVDDEIEANLEE-----FDISEDDIDDGFRRLFAQLAGEDAEISAFELQ 476

Query: 518 YVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRF 577
            +L  VL K++DIK    S+ +CK ++ ++D+ G+GKL   EF + W K++++  ++   
Sbjct: 477 TILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREI 536

Query: 578 DADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASR 637
           D D+SGTM++YE+R AL+ AGF++   L Q+IV R+AD++L +DFD+F+ CLVRLE   +
Sbjct: 537 DVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFK 596

Query: 638 VFQALSTKNKEFIHLNI 654
           +F+ L  +N   I L++
Sbjct: 597 IFKQLDPENTGTIELDL 613


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  628 bits (1620), Expect = e-180
 Identities = 320/678 (47%), Positives = 447/678 (65%), Gaps = 46/678 (6%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSER-PQIPFV----WKRPGEIVKNPEFIL 81
           QSFE++R  CL++G LFED  FPA  SSL + +  P    V    W+RP +I+ NP FI+
Sbjct: 64  QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123

Query: 82  GGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEW 141
            G + TDICQG LGDCWLLAAI SLT   K L RV+P+ QSF   YAGIFHFQ WQ  +W
Sbjct: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183

Query: 142 LDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
           ++VV+DDRLPT  D+LVF+HS + +EFWSALLEKAYAKL+GSYEAL GGS +E +EDFTG
Sbjct: 184 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTG 243

Query: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGI 261
           GVA++FQ +  P+N   +L KA++R SL+GC I+  S +E E+ T   L++GHAYSVTG+
Sbjct: 244 GVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGL 303

Query: 262 DQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFK 296
             V +RG+   LIR+RNPWG++EWNG+WSD                          M+++
Sbjct: 304 QDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWMSYQ 363

Query: 297 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKL 356
           DF  +F  +EICNLTPD L  D    W  T ++GSW RGS+AGGCRN   TFWTNPQ K+
Sbjct: 364 DFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKI 423

Query: 357 SLTEKDEGQEE-------CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPD-----KDE 404
           SL E D+ +++       C+ LVALMQK+ R  ++ GA + TIG+ +Y  P      +D 
Sbjct: 424 SLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQDV 483

Query: 405 HLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKK 464
           HL K+FF  +     S+ F N REVS + +LPPGEYI+IPSTFEPH++ADF LR+F+EK 
Sbjct: 484 HLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKH 543

Query: 465 AITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 524
           + + ++D   +++  E  +      E + +Q F  LF+ VAGE  E+   EL+ +LN + 
Sbjct: 544 SESWELD---EVNYAEQLQEEKV-SEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMA 599

Query: 525 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 584
            K K  K K   L +C+ +I+LMD  G+GKL   EFK+ W KLK+W+++F   D D SGT
Sbjct: 600 IKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGT 659

Query: 585 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 644
           +++YE+R  ++ AG +L++ ++Q++V RYAD++L +DFD F++C +RL+     F  +  
Sbjct: 660 LNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDP 719

Query: 645 KNKEFIHLNINEFIHLTM 662
           KN   I L++ +++ +TM
Sbjct: 720 KNTGHICLSLEQWLQMTM 737


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  455 bits (1170), Expect = e-128
 Identities = 263/672 (39%), Positives = 369/672 (54%), Gaps = 78/672 (11%)

Query: 26  GQSFEQMRQECLQRGTLFEDADFPASNSSLFY------SERPQIPFVWKRPGEIVKNPEF 79
           GQS+E +R  CL  G LF D  FPA   +L Y      SE+ +    W RP E    P+F
Sbjct: 29  GQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAK-GVKWMRPHEFCAEPKF 87

Query: 80  ILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHS 139
           I    +RTD+CQG LG+CW LAA ASLTL  + L RV+P  Q F  GYAG+FHFQ WQ  
Sbjct: 88  ICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFG 147

Query: 140 EWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDF 199
            W+DVV+DDRLP    +L+F+ S   NEFW+ LLEKAYAKL+GSYE ++GG   EA  DF
Sbjct: 148 RWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDF 207

Query: 200 TGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVT 259
           TGGV E    ++     +  L  AL + SL+G    T  +   E RT  GL+KGHAYS+T
Sbjct: 208 TGGVGEVLYLRQNSMGLFSALRHALAKESLVGA---TALSDRGEYRTEEGLVKGHAYSIT 264

Query: 260 GIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MA 294
           G  +V     ++ L+R+RNPWG VEW G+WSD                          M 
Sbjct: 265 GTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVKKEDGEFWME 324

Query: 295 FKDFKAHFDKVEICNLTPDAL-EEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQ 353
            +DF  HFD V+IC+L+P+ L        W V   QG WVRG  +GG +   +TFWTNPQ
Sbjct: 325 LRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQ 384

Query: 354 IKLSLTEKDEGQEE-------------------------CSFLVALMQKDRRKLKRFGAN 388
            +L+L E DE  +E                         C+ L++L+Q++RR+L+  G  
Sbjct: 385 FRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLT 444

Query: 389 VLTIGYAIYECPDKDEHLNKDFFRYHA-----SRARSKTFINLREVSDRFKLPPGEYILI 443
            LT+G+ +++ P++   L  D  R HA      RA        R+V+ R  L PG Y+++
Sbjct: 445 YLTVGFHVFQIPEELLGL-WDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLVV 503

Query: 444 PSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQ 503
           PST     EADF LR+FSE++    ++D  +  DL     P  P      E     LF++
Sbjct: 504 PSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLP-----LELGLEQLFQE 558

Query: 504 VAGEDMEVTAEELEYVLNAVLQ--KKKDIKFKKLSLISCKNIISLMDTSGNGK-LEFDEF 560
           +AGE+ E+ A +L+ +L+  L+  +      +++ L +C+    L+   G+G+ L    F
Sbjct: 559 LAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCE---QLLQCFGHGQSLALHHF 615

Query: 561 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 620
           +  W  L +W  +F +FD D SGTM++YELR AL AAGF L++ L Q +  RY D  L++
Sbjct: 616 QQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRV 675

Query: 621 DFDDFLNCLVRL 632
           DF+ F++C+  L
Sbjct: 676 DFERFVSCVAHL 687


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  435 bits (1118), Expect = e-122
 Identities = 255/672 (37%), Positives = 378/672 (56%), Gaps = 53/672 (7%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQ-IP--FVWKRPGEIVKNPEFILGG 83
           Q FE +  ECL+ G LFED  FPA+ SS+      Q +P    WKRP E+  NP+F    
Sbjct: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFAK 87

Query: 84  ATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLD 143
           A R D+CQG +GDCW LAA+ +L L+Q  L+RV+P +QSF   YAGIF F FW +  W+ 
Sbjct: 88  AKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVP 147

Query: 144 VVIDDRLPTFR-DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGG 202
           VVIDDRLP     +LVF+ S   N FW ALLEKAYAKL+GSYE L+ G   EA+ DFTGG
Sbjct: 148 VVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGG 207

Query: 203 VAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGID 262
           V  T    EA  N ++IL +A    +L+GC          E     GL++GHAY++TGI 
Sbjct: 208 VTMTINLAEAHGNLWDILIEATYNRTLIGC-----QTHSGEKILENGLVEGHAYTLTGIR 262

Query: 263 QVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFKD 297
           +V+ + +   L+++RNPWG+VEW G WSD                          M  +D
Sbjct: 263 KVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQD 322

Query: 298 FKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFL-DTFWTNPQIKL 356
           FK HF  + IC LTP  L ++A  KW  T+ +G W + STAGG R  L DTFW NPQ  L
Sbjct: 323 FKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLL 382

Query: 357 SLTEKDEGQEE---CSFLVALMQKDRRKLKRFGANVLTIGYAIY---ECPDKDEHLNKDF 410
           S+   +EG+     CS LV+L+QK R + ++    +L IG+ +Y   +  D    L  +F
Sbjct: 383 SVWRPEEGRRSLRPCSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNKYHDDQRRLPPEF 441

Query: 411 FRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDM 470
           F+ +   ++   F+  +EVS    L PG Y+++P   E HQ+++F LR+FS +K I  ++
Sbjct: 442 FQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFS-RKHIFYEI 500

Query: 471 DGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDI 530
             N  +   +  +    DQ   +++ F   FE    +  E+ A +L+ +LN +       
Sbjct: 501 GSNSGVVFSKEIE----DQNERQDEFFTKFFE----KHPEINAVQLQNLLNQMTWSSLGS 552

Query: 531 KFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYEL 590
           +    SL +C+ I++L+D + +G +   EF+  W +LK    +F + D   SG ++  +L
Sbjct: 553 RQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGYLNWEQL 611

Query: 591 RTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFI 650
             A++ AG  LS  + QL+++RY    LQ+DF  F++ ++R+EN   VFQ L T++ + I
Sbjct: 612 HAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNL-TQDGKGI 670

Query: 651 HLNINEFIHLTM 662
           +L   E++ + +
Sbjct: 671 YLQKPEWMMMAL 682


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  316 bits (809), Expect = 5e-86
 Identities = 187/513 (36%), Positives = 276/513 (53%), Gaps = 76/513 (14%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATR 86
           Q++  +R++C +R  LFED  FPA++ SL+Y   P     WKRP  I ++P   + G + 
Sbjct: 11  QNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISS 70

Query: 87  TDICQGELGDCWLLAAIASLTLNQKALARVIP--QDQSFGP----GYAGIFHFQFWQHSE 140
            D+ QG++G+CW +AA +SL   +    +VIP  ++Q + P     YAGIFHF FW+  E
Sbjct: 71  HDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGE 130

Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
           W+DVVIDDRLPT  ++L++ HS   NEFW AL+EKAYAKL G Y+AL GG+  +A+ DFT
Sbjct: 131 WVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFT 190

Query: 201 GGVAE-------TFQTKEAPEN-FYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIK 252
           GGV+E        F   E   N  +E + K   RG L+   I   +AA+ EAR   GL+K
Sbjct: 191 GGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVK 250

Query: 253 GHAYSVTGIDQVS--------FRGQRIELIRIRNPWGQVEWNGSWSDR------------ 292
           GHAY+VT + +V         F+ +++++IR+RNPWG+ EWNG WSD             
Sbjct: 251 GHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSER 310

Query: 293 --------------MAFKDFKAHFDKVEICNLTPDALEEDAIHK-WEVTVHQGSWV---- 333
                         M F+D   +F  +  C +   +    +IHK WE     G+W     
Sbjct: 311 EKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTS--HLSIHKTWEEARLHGAWTLHED 368

Query: 334 -RGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFG-ANVLT 391
            R +  GGC N  DTF+ NPQ    + + ++       L+ + Q+ +R  +R G    L 
Sbjct: 369 PRQNRGGGCINHKDTFFQNPQYIFEVKKPED-----EVLICIQQRPKRSTRREGKGENLA 423

Query: 392 IGYAIYECPDKDEHLNKDFFRYHA--SRARSKTFINLREVSDRFKLPPGEYILIPSTFEP 449
           IG+ IY+  +  +      +R H+   +A S  +IN R V  R   P G Y++IP+TFEP
Sbjct: 424 IGFDIYKVEENRQ------YRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEP 477

Query: 450 HQEADFCLRIFSEKKAITRDMDGNVDIDLPEPP 482
               +F LR+F++  +  R      ++ L EPP
Sbjct: 478 GHTGEFLLRVFTDVPSNCR------ELRLDEPP 504


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  276 bits (706), Expect = 4e-74
 Identities = 206/683 (30%), Positives = 330/683 (48%), Gaps = 81/683 (11%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSL---FYSERPQIPFVWKRPGEIVKNP-EFILG 82
           Q F  +R  CL  G  F+D  FPA++SS+      E+     +WKRP ++   P  FIL 
Sbjct: 19  QDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILD 78

Query: 83  GATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWL 142
             +R DI QG   DCW LAA+ SLT N +   +++   QSF   YAGIF F+FWQ  +W+
Sbjct: 79  DISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL-MVQSFSHQYAGIFRFRFWQCGQWV 137

Query: 143 DVVIDDRLPTFRDRLVFLHSADHN-EFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
           +VVIDDRLP   D+ +F+     N EFW  LLEKAYAKL GSY  L  G   +A+ D TG
Sbjct: 138 EVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTG 197

Query: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCF-----IDTRSAAESEARTPFGLIKGHAY 256
           GV        +P +  + ++ A K GSL+ C       DT  A E+      GL+  HAY
Sbjct: 198 GVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMEN------GLVSLHAY 251

Query: 257 SVTGIDQVSFRGQRIELIRIRNP--WGQVEWNGSWSDR---------------------- 292
           +VTG +Q+ +R    E+I + NP  WG+ EW G WSD                       
Sbjct: 252 TVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKREDG 311

Query: 293 ---MAFKDFKAHFDKVEICNLTPDALEE-DAIHK-WEVTVHQGSWVRGSTAGGCRNFLDT 347
              M+ +DF+  F  + IC+  P  L+  + +H+ W   + +   + G+TAGG RN    
Sbjct: 312 EFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN---- 367

Query: 348 FWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLK----RFGANVLTIGYAIYECPDKD 403
              + Q   S+ E  EG      +   +     K +         V+  G   +      
Sbjct: 368 ---DAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFR----- 419

Query: 404 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 463
           E     FF    +  +S      R  +  + L PG Y+++  T    + A+F LRIF + 
Sbjct: 420 EKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLLRIFLKM 477

Query: 464 KAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAV 523
               R +  + ++ +    K +P +  +++     ++F + A + +++ A +L+ +LN  
Sbjct: 478 PDSDRHLSSHFNLRM----KGSPSEHGSQQ-----SIFNRYAQQRLDIDATQLQGLLNQE 528

Query: 524 LQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSG 583
           L           SL  C+++++LM+   NG+L+ +EF   W +L  + ++F +      G
Sbjct: 529 LLTGP--PGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQT-SPG 585

Query: 584 TMSTYELRTALK----AAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVF 639
            + + +L  A++      G  +S  LL L+ LRY+D   ++ F   +  L+RLE  ++ F
Sbjct: 586 VLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTF 645

Query: 640 QALSTKNKEFIHLNINEFIHLTM 662
           + LS K+ + ++L   E++ L M
Sbjct: 646 RNLS-KDGKGLYLTEMEWMSLVM 667


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score =  270 bits (689), Expect = 4e-72
 Identities = 130/302 (43%), Positives = 189/302 (62%), Gaps = 43/302 (14%)

Query: 404 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 463
           +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+++PST+EPHQE +F LR+FSEK
Sbjct: 6   QHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEK 65

Query: 464 KAITRDMDGNVDIDLPEPPKPTPP------------------------------------ 487
           + ++ +++  + +D P   K T P                                    
Sbjct: 66  RNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSP 125

Query: 488 -------DQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISC 540
                  DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC
Sbjct: 126 QPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESC 185

Query: 541 KNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQ 600
           +++I+LMDT G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF 
Sbjct: 186 RSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFH 245

Query: 601 LSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHL 660
           L++ L  +I +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ L
Sbjct: 246 LNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQL 305

Query: 661 TM 662
           TM
Sbjct: 306 TM 307


>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score =  258 bits (659), Expect = 1e-68
 Identities = 169/511 (33%), Positives = 261/511 (51%), Gaps = 75/511 (14%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATR 86
           Q +++++QEC++   LF D  F   N SLFY+       VWKRP +I  +P  I+G  + 
Sbjct: 11  QKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIVGNISN 70

Query: 87  TDICQGELGDCWLLAAIASLTLNQKALARVIP--QDQSFGPG----YAGIFHFQFWQHSE 140
             + QG LG   +++A + L + +    + IP  ++Q + P     YAGIFHF+FW   E
Sbjct: 71  HQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGE 130

Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
           W +VVIDD LPT    LVF  S   NEFW+ALLEKAYAKL G YEAL G +  + + DFT
Sbjct: 131 WTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFT 190

Query: 201 GGVAETFQTK-----EAPENFYEI---LEKALKRGSLLGCFIDTRSAAESEARTPFGLIK 252
           G +AET   +     E  E  Y++   L K   +G L+ C I++ +  E E  T +GL+K
Sbjct: 191 GTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLK 250

Query: 253 GHAYSVTGIDQVS--------FRGQRIELIRIRNPWGQVEWNGSWS------------DR 292
           GH Y++T I ++         F  +++ ++R+RNP G+ EW+G WS            DR
Sbjct: 251 GHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDR 310

Query: 293 --------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRG--- 335
                         M+ +DF  +F K+ +C    + +      + E+    G W      
Sbjct: 311 KNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPI----FGRKELESVLGCWTVDDDP 366

Query: 336 --STAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGA-NVLTI 392
             + +GGC N  DTF  NPQ   ++ E          +++L QKD R  +R G  +   I
Sbjct: 367 LMNRSGGCYNNRDTFLQNPQYIFTVPEDGH-----KVIMSLQQKDLRTYRRMGRPDNYII 421

Query: 393 GYAIYECPDKDEHLNKDFFRYHA---SRARSKTFINLREVSDRFKLPPGEYILIPSTFEP 449
           G+ +++       +N+ F  +H     RA + T+I+ R V     L  G Y+L+P+ F+ 
Sbjct: 422 GFELFKV-----EMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQH 476

Query: 450 HQEADFCLRIFSEKKAITRDMDGNVDIDLPE 480
            + ++F LRIFSE     R++     +D+P+
Sbjct: 477 GRTSEFLLRIFSEVPVQLREL----TLDMPK 503


>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score =  174 bits (442), Expect = 2e-43
 Identities = 141/488 (28%), Positives = 214/488 (43%), Gaps = 81/488 (16%)

Query: 42  LFEDADFPASNSSLFYS-ERPQIPF----VWKRPGEIVKNPEFILGGATRTDICQGELGD 96
           LF DA FPA++SSLF     P   F     W+RP EI   P           + QG LGD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 97  CWLLAAIASLTLNQKALARVIPQDQSFGPG--YAGIFHFQFWQHSEWLDVVIDDRLPTFR 154
           CW L A A+L  ++  L +VIP  Q       Y G F  + WQ   W++V  DDRLP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 155 DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTK---- 210
            RL F      + FW  LLEK YAK++GSYE L  G   +A+ D TGG+AE +  K    
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192

Query: 211 -----EAPENFYEILEKAL---KRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGID 262
                + P  +     + L   K   L+ C + +  A   E      L + HA+ V+ + 
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFHAFIVSDLR 246

Query: 263 QVSFR-GQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFK 296
           ++  + GQ I L+RI+NPWG+  W G W +                          +  +
Sbjct: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEE 306

Query: 297 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ----GSWVRGSTAGGCRNFLDTFWTNP 352
           +F   FD++ +     +A    +++   +  H     G+WV+G +AGGCRN    F +NP
Sbjct: 307 EFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSNP 365

Query: 353 QIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTI------GYAIYECPDKD-EH 405
           +  L ++E  E        +A++Q+ R     +      +       ++    P K  + 
Sbjct: 366 KFWLRVSEPSE------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQA 419

Query: 406 LNKDFFRYHASRARSKTFINL------------REVSDRFKLPPGEYILIPSTFEPHQEA 453
           +    ++    R      +++            REV  R +L PG Y+ +PSTF      
Sbjct: 420 VGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPG 479

Query: 454 DFCLRIFS 461
           +F LR+FS
Sbjct: 480 EFLLRVFS 487



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 40/138 (28%), Positives = 56/138 (40%), Gaps = 8/138 (5%)

Query: 322 KWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRK 381
           +W     +GSW  G TAGG RNF  ++ TNP    S+    EG       + L Q  R  
Sbjct: 513 EWGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV---PEGPGPRCVRITLHQHCRPS 568

Query: 382 LKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 441
              F      IG+ I++ P+     +                   +EVS    LP G Y 
Sbjct: 569 DTEFH----PIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYK 624

Query: 442 LIPSTFEPHQEADFCLRI 459
           ++PST+ P  E  F + I
Sbjct: 625 VVPSTYLPDTEGAFTVTI 642


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  167 bits (423), Expect = 3e-41
 Identities = 138/488 (28%), Positives = 208/488 (42%), Gaps = 83/488 (17%)

Query: 42  LFEDADFPASNSSLFYS-ERPQIPF----VWKRPGEIVKNPEFILGGATRTDICQGELGD 96
           LF DA FPA++SSLF     P   F     W+RP EI   P           + QG LGD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 97  CWLLAAIASLTLNQKALARVIPQDQSFGPG--YAGIFHFQFWQHSEWLDVVIDDRLPTFR 154
           CW L A A+L  ++  L +VIP  Q       Y G F  + WQ   W++V  DDRLP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 155 DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTK---- 210
            RL F      + FW  LLEK YAK++GSYE L  G   +A+ D TGG+AE +  K    
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192

Query: 211 -----EAPENFYEILEKAL---KRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGID 262
                + P  +     + L   K   L+ C + +  A   E      L + HA+ V+ + 
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFHAFIVSDLR 246

Query: 263 QVSFR-GQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFK 296
           ++  + GQ I L+RI+NPWG+  W G W +                          +  +
Sbjct: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEE 306

Query: 297 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ----GSWVRGSTAGGCRNFLDTFWTNP 352
           +F   FD++ +     +A    +++   +  H     G+WV+G +AGGCRN    F +NP
Sbjct: 307 EFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSNP 365

Query: 353 QIKLSLTEKDEGQEECSFLVALMQKDRRKLKRF---------------------GANVLT 391
           +  L ++E  E        +A++Q+ R     +                     G +   
Sbjct: 366 KFWLRVSEPSE------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQA 419

Query: 392 IGYAIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQ 451
           +G  +++ P+     +                   +EVS    LP G Y ++PST+ P  
Sbjct: 420 VGLHLWKVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDT 479

Query: 452 EADFCLRI 459
           E  F + I
Sbjct: 480 EGAFTVTI 487


>gi|14161692 calpain small subunit 2 [Homo sapiens]
          Length = 248

 Score =  166 bits (419), Expect = 8e-41
 Identities = 84/189 (44%), Positives = 126/189 (66%), Gaps = 8/189 (4%)

Query: 482 PKPTPPDQ--------ETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFK 533
           P+P P  Q        E+EE +RFR  F Q+AG DMEV A +L  +LN VL K KD+K  
Sbjct: 58  PEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTD 117

Query: 534 KLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTA 593
             SL +C++I+S+MD+   GKL F+EFK  W+ +K+W  ++ ++D D SG++ + +LR A
Sbjct: 118 GFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGA 177

Query: 594 LKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLN 653
           L+AAGFQL+  L Q+IV RYA+E+  +DF++F++CLVRL+   R F++L       I ++
Sbjct: 178 LQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVS 237

Query: 654 INEFIHLTM 662
           I E++ LTM
Sbjct: 238 IKEWLQLTM 246


>gi|4502565 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  165 bits (417), Expect = 1e-40
 Identities = 80/189 (42%), Positives = 124/189 (65%), Gaps = 5/189 (2%)

Query: 479 PEPPKPTP-----PDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFK 533
           PEPP P          E+EE ++FR LF Q+AG+DMEV+A EL  +LN V+ +  D+K  
Sbjct: 78  PEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTD 137

Query: 534 KLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTA 593
              + +C++++++MD+   GKL F+EFK  W+ +K+W  ++ +FD D+SGT+ + EL  A
Sbjct: 138 GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGA 197

Query: 594 LKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLN 653
            +AAGF L+ HL  +I+ RY+DE   +DFD+F++CLVRL+   R F++L       I +N
Sbjct: 198 FEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVN 257

Query: 654 INEFIHLTM 662
           I E++ LTM
Sbjct: 258 IQEWLQLTM 266


>gi|51599151 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  165 bits (417), Expect = 1e-40
 Identities = 80/189 (42%), Positives = 124/189 (65%), Gaps = 5/189 (2%)

Query: 479 PEPPKPTP-----PDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFK 533
           PEPP P          E+EE ++FR LF Q+AG+DMEV+A EL  +LN V+ +  D+K  
Sbjct: 78  PEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTD 137

Query: 534 KLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTA 593
              + +C++++++MD+   GKL F+EFK  W+ +K+W  ++ +FD D+SGT+ + EL  A
Sbjct: 138 GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGA 197

Query: 594 LKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLN 653
            +AAGF L+ HL  +I+ RY+DE   +DFD+F++CLVRL+   R F++L       I +N
Sbjct: 198 FEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVN 257

Query: 654 INEFIHLTM 662
           I E++ LTM
Sbjct: 258 IQEWLQLTM 266


>gi|27765080 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  150 bits (380), Expect = 3e-36
 Identities = 70/154 (45%), Positives = 102/154 (66%)

Query: 509 MEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLK 568
           ME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMDT G+GKL   EF   W+K+K
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 569 QWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNC 628
            W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +I +RYAD+ + +DFD F+ C
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 629 LVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 662
            VRLE   R F A        I LN+ E++ LTM
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 154


>gi|27765078 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  150 bits (380), Expect = 3e-36
 Identities = 70/154 (45%), Positives = 102/154 (66%)

Query: 509 MEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLK 568
           ME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMDT G+GKL   EF   W+K+K
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 569 QWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNC 628
            W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +I +RYAD+ + +DFD F+ C
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 629 LVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 662
            VRLE   R F A        I LN+ E++ LTM
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 154


>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score =  126 bits (316), Expect = 7e-29
 Identities = 122/457 (26%), Positives = 177/457 (38%), Gaps = 84/457 (18%)

Query: 36  CLQRGTLFEDADFPASNSSLFYSERPQIPF---VWKRPGEIV-------KNPEFILGGAT 85
           C +    F D  FP    S+ +     +      W RP EI        +    +     
Sbjct: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540

Query: 86  RTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVV 145
            +DI QG LG+CW L+A+A L      + RV+        G    +  +  +   W  V+
Sbjct: 541 PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEG---AYQVRLCKDGTWTTVL 597

Query: 146 IDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAE 205
           +DD LP      +    A   + W AL+EKA AKL+GSY AL+ G AIE +   TG   E
Sbjct: 598 VDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCE 657

Query: 206 TF-------QTKEAPENFYEILEKAL---KRGSLLGCFI-DTRSAAESEARTPFGLIKGH 254
           +          +E P +   I  K L   + G L+G          +  A    GL   H
Sbjct: 658 SLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRH 717

Query: 255 AYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR---------------------- 292
           AYS+  +  V    Q   L+R+RNPWG+  WNGSWSD                       
Sbjct: 718 AYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRGELMPHGSSEGVF 773

Query: 293 -MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTN 351
            M + DF  +FD V+IC +  D         W+    QG +   ++A             
Sbjct: 774 WMEYGDFVRYFDSVDICKVHSD---------WQEARVQGCFPSSASA------------- 811

Query: 352 PQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECP-DKDEHLNKDF 410
           P    +LT      E  S   AL Q+  R+     +++L +   ++        HL+   
Sbjct: 812 PVGVTALTV----LERASLEFALFQEGSRRSDAVDSHLLDLCILVFRATFGSGGHLSLGR 867

Query: 411 FRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTF 447
              H+ RA  K       VS    L PGEY ++   F
Sbjct: 868 LLAHSKRAVKKF------VSCDVMLEPGEYAVVCCAF 898


>gi|38679884 sorcin isoform b [Homo sapiens]
          Length = 183

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 52/164 (31%), Positives = 89/164 (54%), Gaps = 4/164 (2%)

Query: 501 FEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEF 560
           F  VAG+D ++ A+EL+  L    Q      +K  +L +C+ ++S++D   +G + F+EF
Sbjct: 24  FAAVAGQDGQIDADELQRCLT---QSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEF 80

Query: 561 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 620
           K  W  L  W   F+ FD D+SGT+   EL+ AL   GF+LS   +  I  RY+    ++
Sbjct: 81  KELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNG-KI 139

Query: 621 DFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI 664
            FDD++ C V+L   +  F+   T  +  ++   ++FI   M++
Sbjct: 140 TFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 183


>gi|4507207 sorcin isoform a [Homo sapiens]
          Length = 198

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 52/164 (31%), Positives = 89/164 (54%), Gaps = 4/164 (2%)

Query: 501 FEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEF 560
           F  VAG+D ++ A+EL+  L    Q      +K  +L +C+ ++S++D   +G + F+EF
Sbjct: 39  FAAVAGQDGQIDADELQRCLT---QSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEF 95

Query: 561 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 620
           K  W  L  W   F+ FD D+SGT+   EL+ AL   GF+LS   +  I  RY+    ++
Sbjct: 96  KELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNG-KI 154

Query: 621 DFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI 664
            FDD++ C V+L   +  F+   T  +  ++   ++FI   M++
Sbjct: 155 TFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 198


>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
           sapiens]
          Length = 217

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 55/164 (33%), Positives = 87/164 (53%), Gaps = 4/164 (2%)

Query: 501 FEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEF 560
           F  VAG+D EV AEEL+  L    Q   +  +   SL +C+ +I+++D    GK+ F+ F
Sbjct: 58  FSAVAGQDGEVDAEELQRCLT---QSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAF 114

Query: 561 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 620
           K  W  L  W   F+  D D SGT+  +ELR A+   G++LS   L  IV RY+ +  ++
Sbjct: 115 KELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYS-KNGRI 173

Query: 621 DFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI 664
            FDD++ C V+L   +  F+      +   +   ++F+  TM I
Sbjct: 174 FFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI 217


>gi|7656959 calpain 7 [Homo sapiens]
          Length = 813

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 68/240 (28%), Positives = 113/240 (47%), Gaps = 24/240 (10%)

Query: 67  WKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIA-----SLTLNQKALARVI-PQD 120
           W RP ++  NP  I    +   I Q  + DC  +A++A         N+K +  +I PQ+
Sbjct: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319

Query: 121 QSFGPGYAGIFHFQFWQHSEWLD--VVIDDRLPT-FRDRLVFLHSADHNEFWSALLEKAY 177
           +   P Y     +    H   +   V+IDD+LP   +  L+  +S + +E W +L+EKAY
Sbjct: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379

Query: 178 AKLNGSYEALKGGSAIEAMEDFTGGVAETF------QTKEAPENFYEILEKALKRGSLLG 231
            K+ G Y+     S I+ +   TG + E        QT     +F  + ++  K   L+ 
Sbjct: 380 MKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLIT 438

Query: 232 CFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSD 291
                 + AE E    +GL+  HAY+V  +D   F+G R   I+++NPW  + W G +S+
Sbjct: 439 ASTGMMTEAEGE---KWGLVPTHAYAV--LDIREFKGLR--FIQLKNPWSHLRWKGRYSE 491


>gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]
          Length = 284

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 37/125 (29%), Positives = 67/125 (53%), Gaps = 2/125 (1%)

Query: 539 SCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAG 598
           +C  +I++ D + +G+++   F   W  ++QW NLF ++D D+SG++S  EL+ AL   G
Sbjct: 155 TCLMMINMFDKTKSGRIDVYGFSALWKFIQQWKNLFQQYDRDRSGSISYTELQQALSQMG 214

Query: 599 FQLSSHLLQLIVLRYADEELQ--LDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINE 656
           + LS    QL+V RY        +  D F+    +L+  +  F+   T  +  I L+  +
Sbjct: 215 YNLSPQFTQLLVSRYCPRSANPAMQLDRFIQVCTQLQVLTEAFREKDTAVQGNIRLSFED 274

Query: 657 FIHLT 661
           F+ +T
Sbjct: 275 FVTMT 279


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,610,279
Number of Sequences: 37866
Number of extensions: 1249532
Number of successful extensions: 4224
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 4001
Number of HSP's gapped (non-prelim): 128
length of query: 664
length of database: 18,247,518
effective HSP length: 109
effective length of query: 555
effective length of database: 14,120,124
effective search space: 7836668820
effective search space used: 7836668820
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.