Search of human proteins with 5729758

Search of human proteins with 5729758

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5729758 calpain 9 isoform 1 [Homo sapiens]
         (690 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5729758 calpain 9 isoform 1 [Homo sapiens]                        1414   0.0  
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                        1340   0.0  
gi|27765074 calpain 3 isoform c [Homo sapiens]                        814   0.0  
gi|27765072 calpain 3 isoform b [Homo sapiens]                        780   0.0  
gi|4557405 calpain 3 isoform a [Homo sapiens]                         776   0.0  
gi|12408656 calpain 1, large subunit [Homo sapiens]                   752   0.0  
gi|47078247 calpain 3 isoform f [Homo sapiens]                        730   0.0  
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       726   0.0  
gi|221554549 calpain 8 [Homo sapiens]                                 722   0.0  
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       689   0.0  
gi|215490104 calpain 11 [Homo sapiens]                                664   0.0  
gi|38707981 calpain 12 [Homo sapiens]                                 487   e-137
gi|223468608 calpain 14 [Homo sapiens]                                468   e-131
gi|37577157 calpain 5 [Homo sapiens]                                  358   7e-99
gi|41152101 calpain 13 [Homo sapiens]                                 309   5e-84
gi|13186316 calpain 6 [Homo sapiens]                                  296   4e-80
gi|27765076 calpain 3 isoform d [Homo sapiens]                        270   4e-72
gi|13186302 calpain 10 isoform a [Homo sapiens]                       202   6e-52
gi|89353291 calpain 10 isoform c [Homo sapiens]                       195   1e-49
gi|14161692 calpain small subunit 2 [Homo sapiens]                    166   9e-41
gi|4502565 calpain, small subunit 1 [Homo sapiens]                    165   1e-40
gi|51599151 calpain, small subunit 1 [Homo sapiens]                   165   1e-40
gi|27765080 calpain 3 isoform e [Homo sapiens]                        150   3e-36
gi|27765078 calpain 3 isoform e [Homo sapiens]                        150   3e-36
gi|5032105 small optic lobes [Homo sapiens]                           145   9e-35
gi|38679884 sorcin isoform b [Homo sapiens]                            94   3e-19
gi|4507207 sorcin isoform a [Homo sapiens]                             94   3e-19
gi|7656959 calpain 7 [Homo sapiens]                                    92   2e-18
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap...    89   1e-17
gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]            74   6e-13

>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score = 1414 bits (3661), Expect = 0.0
 Identities = 690/690 (100%), Positives = 690/690 (100%)

Query: 1   MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60
           MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER
Sbjct: 1   MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60

Query: 61  PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120
           PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD
Sbjct: 61  PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120

Query: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180
           QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL
Sbjct: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180

Query: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240
           NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA
Sbjct: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240

Query: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVG 300
           ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVG
Sbjct: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVG 300

Query: 301 PAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR 360
           PAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR
Sbjct: 301 PAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR 360

Query: 361 GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY 420
           GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY
Sbjct: 361 GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY 420

Query: 421 AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD 480
           AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD
Sbjct: 421 AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD 480

Query: 481 FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE 540
           FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE
Sbjct: 481 FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE 540

Query: 541 ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF 600
           ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF
Sbjct: 541 ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF 600

Query: 601 LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN 660
           LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN
Sbjct: 601 LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN 660

Query: 661 ASRVFQALSTKNKEFIHLNINEFIHLTMNI 690
           ASRVFQALSTKNKEFIHLNINEFIHLTMNI
Sbjct: 661 ASRVFQALSTKNKEFIHLNINEFIHLTMNI 690


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score = 1340 bits (3468), Expect = 0.0
 Identities = 663/690 (96%), Positives = 663/690 (96%), Gaps = 26/690 (3%)

Query: 1   MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60
           MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER
Sbjct: 1   MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60

Query: 61  PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120
           PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD
Sbjct: 61  PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120

Query: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180
           QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL
Sbjct: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180

Query: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240
           NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA
Sbjct: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240

Query: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVG 300
           ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSD         
Sbjct: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------- 292

Query: 301 PAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR 360
                             MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR
Sbjct: 293 ------------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR 334

Query: 361 GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY 420
           GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY
Sbjct: 335 GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY 394

Query: 421 AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD 480
           AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD
Sbjct: 395 AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD 454

Query: 481 FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE 540
           FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE
Sbjct: 455 FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE 514

Query: 541 ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF 600
           ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF
Sbjct: 515 ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF 574

Query: 601 LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN 660
           LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN
Sbjct: 575 LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN 634

Query: 661 ASRVFQALSTKNKEFIHLNINEFIHLTMNI 690
           ASRVFQALSTKNKEFIHLNINEFIHLTMNI
Sbjct: 635 ASRVFQALSTKNKEFIHLNINEFIHLTMNI 664


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score =  814 bits (2102), Expect = 0.0
 Identities = 386/713 (54%), Positives = 517/713 (72%), Gaps = 33/713 (4%)

Query: 6   RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43
           R+PGP  HP    A  T + G                      ++FEQ+ ++CL++  L+
Sbjct: 18  RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75

Query: 44  EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103
            D +FP   +SLFYS++  I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 76  VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135

Query: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163
           A LTLNQ  L RVIP DQSF   YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S 
Sbjct: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195

Query: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223
             NEFWSALLEKAYAKL+GSYEALKGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255

Query: 224 LKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQV 283
           ++RGSL+GC IDT    + E R   GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQV
Sbjct: 256 IERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQV 315

Query: 284 EWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEE 343
           EWNGSWSD   +W  V   E+ RL H   +DGEFWM+++DF  HF K+EICNLT DAL+ 
Sbjct: 316 EWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQS 375

Query: 344 DAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVA 399
           D +  W V+V++G WVRG +AGGCRNF DTFWTNPQ +L L E+D+  ++    CSFLVA
Sbjct: 376 DKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVA 435

Query: 400 LMQKDRRKLKRFGANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREV 455
           LMQK+RRK ++ GA++ TIG+AIYE P +     +HL KDFF Y+AS+ARSKT+IN+REV
Sbjct: 436 LMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREV 495

Query: 456 SDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQ 515
           S RF+LPP EY+++PST+EPHQE +F LR+FSEK+ ++ +++  + +D P  P+P   DQ
Sbjct: 496 SQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRP-VPQPGSSDQ 554

Query: 516 ETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDT 575
           E+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMDT
Sbjct: 555 ESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDT 614

Query: 576 SGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLI 635
            G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +I
Sbjct: 615 DGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDII 674

Query: 636 VLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 688
            +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ LTM
Sbjct: 675 TMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 727


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score =  780 bits (2014), Expect = 0.0
 Identities = 387/798 (48%), Positives = 518/798 (64%), Gaps = 117/798 (14%)

Query: 6   RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43
           R+PGP  HP    A  T + G                      ++FEQ+ ++CL++  L+
Sbjct: 18  RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75

Query: 44  EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103
            D +FP   +SLFYS++  I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 76  VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135

Query: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163
           A LTLNQ  L RVIP DQSF   YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S 
Sbjct: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195

Query: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223
             NEFWSALLEKAYAKL+GSYEALKGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255

Query: 224 LKRGSLLGCFID------------------------------------------------ 235
           ++RGSL+GC ID                                                
Sbjct: 256 IERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTR 315

Query: 236 TRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPE 295
           T    + E R   GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQVEWNGSWSD   +
Sbjct: 316 TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKD 375

Query: 296 WRSVGPAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ 355
           W  V   E+ RL H   +DGEFWM+++DF  HF K+EICNLT DAL+ D +  W V+V++
Sbjct: 376 WSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNE 435

Query: 356 GSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRF 411
           G WVRG +AGGCRNF DTFWTNPQ +L L E+D+  ++    CSFLVALMQK+RRK ++ 
Sbjct: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495

Query: 412 GANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 467
           GA++ TIG+AIYE P +     +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+
Sbjct: 496 GASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYV 555

Query: 468 LIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEP-------------------- 507
           ++PST+EPHQE +F LR+FSEK+ ++ +++  + +D P P                    
Sbjct: 556 IVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQES 615

Query: 508 -----------------PKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 550
                            P+P   DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+
Sbjct: 616 EEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVV 675

Query: 551 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 610
            K KD+K    +L SC+++I+LMDT G+GKL   EF   W+K+K W  +F  +D D+SGT
Sbjct: 676 NKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGT 735

Query: 611 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 670
           +++YE+R A+  AGF L++ L  +I +RYAD+ + +DFD F+ C VRLE   R F A   
Sbjct: 736 INSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDK 795

Query: 671 KNKEFIHLNINEFIHLTM 688
                I LN+ E++ LTM
Sbjct: 796 DGDGIIKLNVLEWLQLTM 813


>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score =  776 bits (2003), Expect = 0.0
 Identities = 387/804 (48%), Positives = 517/804 (64%), Gaps = 123/804 (15%)

Query: 6   RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43
           R+PGP  HP    A  T + G                      ++FEQ+ ++CL++  L+
Sbjct: 18  RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75

Query: 44  EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103
            D +FP   +SLFYS++  I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 76  VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135

Query: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163
           A LTLNQ  L RVIP DQSF   YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S 
Sbjct: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195

Query: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223
             NEFWSALLEKAYAKL+GSYEALKGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255

Query: 224 LKRGSLLGCFID------------------------------------------------ 235
           ++RGSL+GC ID                                                
Sbjct: 256 IERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTR 315

Query: 236 TRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPE 295
           T    + E R   GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQVEWNGSWSD   +
Sbjct: 316 TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKD 375

Query: 296 WRSVGPAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ 355
           W  V   E+ RL H   +DGEFWM+++DF  HF K+EICNLT DAL+ D +  W V+V++
Sbjct: 376 WSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNE 435

Query: 356 GSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRF 411
           G WVRG +AGGCRNF DTFWTNPQ +L L E+D+  ++    CSFLVALMQK+RRK ++ 
Sbjct: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495

Query: 412 GANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 467
           GA++ TIG+AIYE P +     +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+
Sbjct: 496 GASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYV 555

Query: 468 LIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPP-------------- 513
           ++PST+EPHQE +F LR+FSEK+ ++ +++  + +D P   K T P              
Sbjct: 556 IVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKEL 615

Query: 514 -----------------------------DQETEEEQRFRALFEQVAGEDMEVTAEELEY 544
                                        DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ 
Sbjct: 616 GVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKK 675

Query: 545 VLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFD 604
           VLN V+ K KD+K    +L SC+++I+LMDT G+GKL   EF   W+K+K W  +F  +D
Sbjct: 676 VLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYD 735

Query: 605 ADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRV 664
            D+SGT+++YE+R A+  AGF L++ L  +I +RYAD+ + +DFD F+ C VRLE   R 
Sbjct: 736 TDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRA 795

Query: 665 FQALSTKNKEFIHLNINEFIHLTM 688
           F A        I LN+ E++ LTM
Sbjct: 796 FHAFDKDGDGIIKLNVLEWLQLTM 819


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  752 bits (1942), Expect = 0.0
 Identities = 368/679 (54%), Positives = 488/679 (71%), Gaps = 21/679 (3%)

Query: 26  GQSFEQMRQECLQRGTLFEDADFPASNSSLFYSE-----RPQIPFVWKRPGEIVKNPEFI 80
           GQ +EQ+R  CLQ GTLF D  FP    SL Y +            WKRP E++ NP+FI
Sbjct: 39  GQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFI 98

Query: 81  LGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSE 140
           + GATRTDICQG LGDCWLLAAIASLTLN   L RV+P  QSF  GYAGIFHFQ WQ  E
Sbjct: 99  VDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGE 158

Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
           W+DVV+DD LP    +LVF+HSA+ NEFWSALLEKAYAK+NGSYEAL GGS  E  EDFT
Sbjct: 159 WVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFT 218

Query: 201 GGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260
           GGV E ++ ++AP + Y+I+ KAL+RGSLLGC ID  S  + EA T   L+KGHAYSVTG
Sbjct: 219 GGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTG 278

Query: 261 IDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMA 320
             QV++RGQ + LIR+RNPWG+VEW G+WSDSS EW +V P E+ +L    ++DGEFWM+
Sbjct: 279 AKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQL-RVKMEDGEFWMS 337

Query: 321 FKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQI 380
           F+DF   F ++EICNLTPDAL+   I KW  T+++G+W RGSTAGGCRN+  TFW NPQ 
Sbjct: 338 FRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQF 397

Query: 381 KLSLTEKDE----GQEE--CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----D 429
           K+ L E D+    G  E  CSF++ALMQK RR+ +RFG ++ TIG+A+YE P +      
Sbjct: 398 KIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPA 457

Query: 430 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 489
            HL +DFF  +ASRARS+ FINLREVS RF+LPPGEY+++PSTFEP++E DF LR FSEK
Sbjct: 458 VHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEK 517

Query: 490 KAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAV 549
            A T ++D  +  +LP+    +    E E ++ F+ALF Q+AGEDME++ +EL  +LN +
Sbjct: 518 SAGTVELDDQIQANLPDEQVLS----EEEIDENFKALFRQLAGEDMEISVKELRTILNRI 573

Query: 550 LQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSG 609
           + K KD++ K  SL SC+++++LMD  GNGKL   EF + W++++ ++++F +FD DKSG
Sbjct: 574 ISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSG 633

Query: 610 TMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALS 669
           +MS YE+R A+++AGF+L+  L +LI+ RY++ +L +DFD+F+ CLVRLE   R F+ L 
Sbjct: 634 SMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLD 693

Query: 670 TKNKEFIHLNINEFIHLTM 688
           T     +  ++ +++ LTM
Sbjct: 694 TDLDGVVTFDLFKWLQLTM 712


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score =  730 bits (1884), Expect = 0.0
 Identities = 357/714 (50%), Positives = 476/714 (66%), Gaps = 93/714 (13%)

Query: 68  KRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGY 127
           ++  EI +NP FI+ GA RTDICQGELGDCW LAAIA LTLNQ  L RVIP DQSF   Y
Sbjct: 13  QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY 72

Query: 128 AGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEAL 187
           AGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S   NEFWSALLEKAYAKL+GSYEAL
Sbjct: 73  AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEAL 132

Query: 188 KGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFID------------ 235
           KGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA++RGSL+GC ID            
Sbjct: 133 KGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPS 192

Query: 236 ------------------------------------TRSAAESEARTPFGLIKGHAYSVT 259
                                               T    + E R   GL++GHAYSVT
Sbjct: 193 GLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVT 252

Query: 260 GIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWM 319
           G+D+V F+G++++L+R+RNPWGQVEWNGSWSD   +W  V   E+ RL H   +DGEFWM
Sbjct: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312

Query: 320 AFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQ 379
           +++DF  HF K+EICNLT DAL+ D +  W V+V++G WVRG +AGGCRNF DTFWTNPQ
Sbjct: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQ 372

Query: 380 IKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK----DEH 431
            +L L E+D+  ++    CSFLVALMQK+RRK ++ GA++ TIG+AIYE P +     +H
Sbjct: 373 YRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQH 432

Query: 432 LNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKA 491
           L KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+++PST+EPHQE +F LR+FSEK+ 
Sbjct: 433 LQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRN 492

Query: 492 ITRDMDGNVDIDLPEP-------------------------------------PKPTPPD 514
           ++ +++  + +D P P                                     P+P   D
Sbjct: 493 LSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSD 552

Query: 515 QETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMD 574
           QE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMD
Sbjct: 553 QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMD 612

Query: 575 TSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQL 634
           T G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +
Sbjct: 613 TDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDI 672

Query: 635 IVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 688
           I +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ LTM
Sbjct: 673 ITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 726


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  726 bits (1873), Expect = 0.0
 Identities = 351/668 (52%), Positives = 481/668 (72%), Gaps = 20/668 (2%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIP-----FVWKRPGEIVKNPEFIL 81
           Q +E +R ECL+ GTLF+D  FPA  S+L + E            WKRP EI  +P+FI+
Sbjct: 30  QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFII 89

Query: 82  GGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEW 141
           GGATRTDICQG LGDCWLLAAIASLTLN++ LARV+P +QSF   YAGIFHFQFWQ+ EW
Sbjct: 90  GGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEW 149

Query: 142 LDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
           ++VV+DDRLPT    L+F+HSA+ +EFWSALLEKAYAK+NG YEAL GG+  E  EDFTG
Sbjct: 150 VEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTG 209

Query: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGI 261
           G+AE ++ K+ P N ++I++KAL++GSLLGC ID  SAA+SEA T   L+KGHAYSVTG 
Sbjct: 210 GIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGA 269

Query: 262 DQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAF 321
           ++V   G   +LIRIRNPWG+VEW G W+D+ P W ++ P E++RL     +DGEFWM+F
Sbjct: 270 EEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH-EDGEFWMSF 328

Query: 322 KDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIK 381
            DF  H+ ++EICNLTPD L  D   KW++T   G+W RGSTAGGCRN+ +TFW NPQ  
Sbjct: 329 SDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYL 388

Query: 382 LSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----DEHL 432
           + L E+DE +E+    C+FLV L+QK RR+ ++ G ++ TIG+ IYE P++     + HL
Sbjct: 389 IKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHL 448

Query: 433 NKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAI 492
           +K+FF  + +R RS TFINLREV +RFKLPPGEYIL+PSTFEP+++ DFC+R+FSEKKA 
Sbjct: 449 SKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKAD 508

Query: 493 TRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQK 552
            + +D  ++ +L E         E + +  FR LF Q+AGED E++A EL+ +L  VL K
Sbjct: 509 YQAVDDEIEANLEE-----FDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAK 563

Query: 553 KKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMS 612
           ++DIK    S+ +CK ++ ++D+ G+GKL   EF + W K++++  ++   D D+SGTM+
Sbjct: 564 RQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMN 623

Query: 613 TYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKN 672
           +YE+R AL+ AGF++   L Q+IV R+AD++L +DFD+F+ CLVRLE   ++F+ L  +N
Sbjct: 624 SYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPEN 683

Query: 673 KEFIHLNI 680
              I L++
Sbjct: 684 TGTIELDL 691


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  722 bits (1863), Expect = 0.0
 Identities = 348/675 (51%), Positives = 476/675 (70%), Gaps = 21/675 (3%)

Query: 26  GQSFEQMRQECLQRGTLFEDADFPASNSSLFYSE----RPQIP-FVWKRPGEIVKNPEFI 80
           GQ F+ +RQ+CL  G LF+D +FPA  S+L Y +     PQ    +WKRP E+  +P+FI
Sbjct: 29  GQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFI 88

Query: 81  LGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSE 140
           +GGATRTDICQG LGDCWLLAAIASLTLN++ L RV+P+DQ F   YAGIFHFQFWQ+ E
Sbjct: 89  VGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGE 148

Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
           W++VVIDDRLPT   +L+FLHS   NEFWSALLEKAYAKLNG YEAL GGS +E  EDFT
Sbjct: 149 WVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFT 208

Query: 201 GGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260
           GG++E +  K+ P N Y+I+ KAL  GSLLGC ID  SAAE+EA T   L+K HAYSVTG
Sbjct: 209 GGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTG 268

Query: 261 IDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMA 320
           +++V+F+G   +LIR+RNPWG+VEW+G+WSD +PEW  + P  ++ L    ++DGEFWM+
Sbjct: 269 VEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEEL-DKKVEDGEFWMS 327

Query: 321 FKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQI 380
             DF   F ++EICNL+PD+L  + +HKW + +  G W RGSTAGGC+N+  T+WTNPQ 
Sbjct: 328 LSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQF 387

Query: 381 KLSLTEKDEGQEE------CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----D 429
           K+ L E DE QEE      C+ L+ LMQK+RR  KR G  +L+IGYA+Y+ P +     D
Sbjct: 388 KIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTD 447

Query: 430 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 489
            HL +DFF  +   AR+ T++NLREVS R +LPPGEY+++PSTFEP ++ +FCLR+FSEK
Sbjct: 448 AHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEK 507

Query: 490 KAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAV 549
           KA   ++ G+V    P  P P+  DQ   E+ +FR LFE++AG+D E+TA  L+ +LN  
Sbjct: 508 KAQALEI-GDVVAGNPYEPHPSEVDQ---EDDQFRRLFEKLAGKDSEITANALKILLNEA 563

Query: 550 LQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSG 609
             K+ DIKF   ++ +C+ +ISL+D++G G L   EFK  W K+++++ ++   D + SG
Sbjct: 564 FSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSG 623

Query: 610 TMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALS 669
           T+  +E+RTAL+ AGF L+S + Q I LRYA  +L ++FD F+ C++RLE   ++F  L 
Sbjct: 624 TIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLD 683

Query: 670 TKNKEFIHLNINEFI 684
                 + L++ E++
Sbjct: 684 EDKDGMVQLSLAEWL 698


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  689 bits (1779), Expect = 0.0
 Identities = 330/618 (53%), Positives = 454/618 (73%), Gaps = 15/618 (2%)

Query: 72  EIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIF 131
           EI  +P+FI+GGATRTDICQG LGDCWLLAAIASLTLN++ LARV+P +QSF   YAGIF
Sbjct: 2   EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61

Query: 132 HFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGS 191
           HFQFWQ+ EW++VV+DDRLPT    L+F+HSA+ +EFWSALLEKAYAK+NG YEAL GG+
Sbjct: 62  HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121

Query: 192 AIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLI 251
             E  EDFTGG+AE ++ K+ P N ++I++KAL++GSLLGC ID  SAA+SEA T   L+
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181

Query: 252 KGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTA 311
           KGHAYSVTG ++V   G   +LIRIRNPWG+VEW G W+D+ P W ++ P E++RL    
Sbjct: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241

Query: 312 LDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFL 371
            +DGEFWM+F DF  H+ ++EICNLTPD L  D   KW++T   G+W RGSTAGGCRN+ 
Sbjct: 242 -EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYP 300

Query: 372 DTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPD 427
           +TFW NPQ  + L E+DE +E+    C+FLV L+QK RR+ ++ G ++ TIG+ IYE P+
Sbjct: 301 NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE 360

Query: 428 K-----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFC 482
           +     + HL+K+FF  + +R RS TFINLREV +RFKLPPGEYIL+PSTFEP+++ DFC
Sbjct: 361 ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC 420

Query: 483 LRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEEL 542
           +R+FSEKKA  + +D  ++ +L E         E + +  FR LF Q+AGED E++A EL
Sbjct: 421 IRVFSEKKADYQAVDDEIEANLEE-----FDISEDDIDDGFRRLFAQLAGEDAEISAFEL 475

Query: 543 EYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLR 602
           + +L  VL K++DIK    S+ +CK ++ ++D+ G+GKL   EF + W K++++  ++  
Sbjct: 476 QTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYRE 535

Query: 603 FDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENAS 662
            D D+SGTM++YE+R AL+ AGF++   L Q+IV R+AD++L +DFD+F+ CLVRLE   
Sbjct: 536 IDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLF 595

Query: 663 RVFQALSTKNKEFIHLNI 680
           ++F+ L  +N   I L++
Sbjct: 596 KIFKQLDPENTGTIELDL 613


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  664 bits (1713), Expect = 0.0
 Identities = 332/679 (48%), Positives = 462/679 (68%), Gaps = 22/679 (3%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSER-PQIPFV----WKRPGEIVKNPEFIL 81
           QSFE++R  CL++G LFED  FPA  SSL + +  P    V    W+RP +I+ NP FI+
Sbjct: 64  QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123

Query: 82  GGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEW 141
            G + TDICQG LGDCWLLAAI SLT   K L RV+P+ QSF   YAGIFHFQ WQ  +W
Sbjct: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183

Query: 142 LDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
           ++VV+DDRLPT  D+LVF+HS + +EFWSALLEKAYAKL+GSYEAL GGS +E +EDFTG
Sbjct: 184 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTG 243

Query: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGI 261
           GVA++FQ +  P+N   +L KA++R SL+GC I+  S +E E+ T   L++GHAYSVTG+
Sbjct: 244 GVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGL 303

Query: 262 DQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAF 321
             V +RG+   LIR+RNPWG++EWNG+WSDS+ EW  V    Q +L H   +DGEFWM++
Sbjct: 304 QDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKT-EDGEFWMSY 362

Query: 322 KDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIK 381
           +DF  +F  +EICNLTPD L  D    W  T ++GSW RGS+AGGCRN   TFWTNPQ K
Sbjct: 363 QDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFK 422

Query: 382 LSLTEKDEGQEE-------CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPD-----KD 429
           +SL E D+ +++       C+ LVALMQK+ R  ++ GA + TIG+ +Y  P      +D
Sbjct: 423 ISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQD 482

Query: 430 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 489
            HL K+FF  +     S+ F N REVS + +LPPGEYI+IPSTFEPH++ADF LR+F+EK
Sbjct: 483 VHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEK 542

Query: 490 KAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAV 549
            + + ++D   +++  E  +      E + +Q F  LF+ VAGE  E+   EL+ +LN +
Sbjct: 543 HSESWELD---EVNYAEQLQEEKV-SEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRM 598

Query: 550 LQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSG 609
             K K  K K   L +C+ +I+LMD  G+GKL   EFK+ W KLK+W+++F   D D SG
Sbjct: 599 AIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSG 658

Query: 610 TMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALS 669
           T+++YE+R  ++ AG +L++ ++Q++V RYAD++L +DFD F++C +RL+     F  + 
Sbjct: 659 TLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMD 718

Query: 670 TKNKEFIHLNINEFIHLTM 688
            KN   I L++ +++ +TM
Sbjct: 719 PKNTGHICLSLEQWLQMTM 737


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  487 bits (1253), Expect = e-137
 Identities = 273/673 (40%), Positives = 383/673 (56%), Gaps = 54/673 (8%)

Query: 26  GQSFEQMRQECLQRGTLFEDADFPASNSSLFY------SERPQIPFVWKRPGEIVKNPEF 79
           GQS+E +R  CL  G LF D  FPA   +L Y      SE+ +    W RP E    P+F
Sbjct: 29  GQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAK-GVKWMRPHEFCAEPKF 87

Query: 80  ILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHS 139
           I    +RTD+CQG LG+CW LAA ASLTL  + L RV+P  Q F  GYAG+FHFQ WQ  
Sbjct: 88  ICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFG 147

Query: 140 EWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDF 199
            W+DVV+DDRLP    +L+F+ S   NEFW+ LLEKAYAKL+GSYE ++GG   EA  DF
Sbjct: 148 RWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDF 207

Query: 200 TGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVT 259
           TGGV E    ++     +  L  AL + SL+G    T  +   E RT  GL+KGHAYS+T
Sbjct: 208 TGGVGEVLYLRQNSMGLFSALRHALAKESLVGA---TALSDRGEYRTEEGLVKGHAYSIT 264

Query: 260 GIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWM 319
           G  +V     ++ L+R+RNPWG VEW G+WSDS P W ++ P E +       +DGEFWM
Sbjct: 265 GTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTL-PTECRDALLVKKEDGEFWM 323

Query: 320 AFKDFKAHFDKVEICNLTPDAL-EEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNP 378
             +DF  HFD V+IC+L+P+ L        W V   QG WVRG  +GG +   +TFWTNP
Sbjct: 324 ELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNP 383

Query: 379 QIKLSLTEKDEGQEE-------------------------CSFLVALMQKDRRKLKRFGA 413
           Q +L+L E DE  +E                         C+ L++L+Q++RR+L+  G 
Sbjct: 384 QFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGL 443

Query: 414 NVLTIGYAIYECPDKDEHLNKDFFRYHA-----SRARSKTFINLREVSDRFKLPPGEYIL 468
             LT+G+ +++ P++   L  D  R HA      RA        R+V+ R  L PG Y++
Sbjct: 444 TYLTVGFHVFQIPEELLGL-WDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLV 502

Query: 469 IPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFE 528
           +PST     EADF LR+FSE++    ++D  +  DL     P  P      E     LF+
Sbjct: 503 VPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLP-----LELGLEQLFQ 557

Query: 529 QVAGEDMEVTAEELEYVLNAVLQ--KKKDIKFKKLSLISCKNIISLMDTSGNGK-LEFDE 585
           ++AGE+ E+ A +L+ +L+  L+  +      +++ L +C+    L+   G+G+ L    
Sbjct: 558 ELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCE---QLLQCFGHGQSLALHH 614

Query: 586 FKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQ 645
           F+  W  L +W  +F +FD D SGTM++YELR AL AAGF L++ L Q +  RY D  L+
Sbjct: 615 FQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLR 674

Query: 646 LDFDDFLNCLVRL 658
           +DF+ F++C+  L
Sbjct: 675 VDFERFVSCVAHL 687


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  468 bits (1203), Expect = e-131
 Identities = 267/673 (39%), Positives = 393/673 (58%), Gaps = 29/673 (4%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQ-IP--FVWKRPGEIVKNPEFILGG 83
           Q FE +  ECL+ G LFED  FPA+ SS+      Q +P    WKRP E+  NP+F    
Sbjct: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFAK 87

Query: 84  ATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLD 143
           A R D+CQG +GDCW LAA+ +L L+Q  L+RV+P +QSF   YAGIF F FW +  W+ 
Sbjct: 88  AKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVP 147

Query: 144 VVIDDRLPTFR-DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGG 202
           VVIDDRLP     +LVF+ S   N FW ALLEKAYAKL+GSYE L+ G   EA+ DFTGG
Sbjct: 148 VVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGG 207

Query: 203 VAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGID 262
           V  T    EA  N ++IL +A    +L+GC          E     GL++GHAY++TGI 
Sbjct: 208 VTMTINLAEAHGNLWDILIEATYNRTLIGC-----QTHSGEKILENGLVEGHAYTLTGIR 262

Query: 263 QVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAFK 322
           +V+ + +   L+++RNPWG+VEW G WSDSS +W  + P E K L     +DGEFWM  +
Sbjct: 263 KVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKE-KILLLRKDNDGEFWMTLQ 321

Query: 323 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFL-DTFWTNPQIK 381
           DFK HF  + IC LTP  L ++A  KW  T+ +G W + STAGG R  L DTFW NPQ  
Sbjct: 322 DFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFL 381

Query: 382 LSLTEKDEGQEE---CSFLVALMQKDRRKLKRFGANVLTIGYAIY---ECPDKDEHLNKD 435
           LS+   +EG+     CS LV+L+QK R + ++    +L IG+ +Y   +  D    L  +
Sbjct: 382 LSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNKYHDDQRRLPPE 440

Query: 436 FFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRD 495
           FF+ +   ++   F+  +EVS    L PG Y+++P   E HQ+++F LR+FS +K I  +
Sbjct: 441 FFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFS-RKHIFYE 499

Query: 496 MDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKD 555
           +  N  +   +  +    DQ   +++ F   FE    +  E+ A +L+ +LN +      
Sbjct: 500 IGSNSGVVFSKEIE----DQNERQDEFFTKFFE----KHPEINAVQLQNLLNQMTWSSLG 551

Query: 556 IKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYE 615
            +    SL +C+ I++L+D + +G +   EF+  W +LK    +F + D   SG ++  +
Sbjct: 552 SRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGYLNWEQ 610

Query: 616 LRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEF 675
           L  A++ AG  LS  + QL+++RY    LQ+DF  F++ ++R+EN   VFQ L T++ + 
Sbjct: 611 LHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNL-TQDGKG 669

Query: 676 IHLNINEFIHLTM 688
           I+L   E++ + +
Sbjct: 670 IYLQKPEWMMMAL 682


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  358 bits (920), Expect = 7e-99
 Identities = 199/513 (38%), Positives = 295/513 (57%), Gaps = 50/513 (9%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATR 86
           Q++  +R++C +R  LFED  FPA++ SL+Y   P     WKRP  I ++P   + G + 
Sbjct: 11  QNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISS 70

Query: 87  TDICQGELGDCWLLAAIASLTLNQKALARVIP--QDQSFGP----GYAGIFHFQFWQHSE 140
            D+ QG++G+CW +AA +SL   +    +VIP  ++Q + P     YAGIFHF FW+  E
Sbjct: 71  HDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGE 130

Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
           W+DVVIDDRLPT  ++L++ HS   NEFW AL+EKAYAKL G Y+AL GG+  +A+ DFT
Sbjct: 131 WVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFT 190

Query: 201 GGVAE-------TFQTKEAPEN-FYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIK 252
           GGV+E        F   E   N  +E + K   RG L+   I   +AA+ EAR   GL+K
Sbjct: 191 GGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVK 250

Query: 253 GHAYSVTGIDQVS--------FRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQ 304
           GHAY+VT + +V         F+ +++++IR+RNPWG+ EWNG WSD+S EW+ V  +E+
Sbjct: 251 GHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSER 310

Query: 305 KRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHK-WEVTVHQGSWV---- 359
           +++  T  DDGEFWM F+D   +F  +  C +   +    +IHK WE     G+W     
Sbjct: 311 EKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTS--HLSIHKTWEEARLHGAWTLHED 368

Query: 360 -RGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFG-ANVLT 417
            R +  GGC N  DTF+ NPQ    + + ++       L+ + Q+ +R  +R G    L 
Sbjct: 369 PRQNRGGGCINHKDTFFQNPQYIFEVKKPED-----EVLICIQQRPKRSTRREGKGENLA 423

Query: 418 IGYAIYECPDKDEHLNKDFFRYHA--SRARSKTFINLREVSDRFKLPPGEYILIPSTFEP 475
           IG+ IY+  +  +      +R H+   +A S  +IN R V  R   P G Y++IP+TFEP
Sbjct: 424 IGFDIYKVEENRQ------YRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEP 477

Query: 476 HQEADFCLRIFSEKKAITRDMDGNVDIDLPEPP 508
               +F LR+F++  +  R      ++ L EPP
Sbjct: 478 GHTGEFLLRVFTDVPSNCR------ELRLDEPP 504


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  309 bits (792), Expect = 5e-84
 Identities = 216/684 (31%), Positives = 343/684 (50%), Gaps = 57/684 (8%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSL---FYSERPQIPFVWKRPGEIVKNP-EFILG 82
           Q F  +R  CL  G  F+D  FPA++SS+      E+     +WKRP ++   P  FIL 
Sbjct: 19  QDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILD 78

Query: 83  GATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWL 142
             +R DI QG   DCW LAA+ SLT N +   +++   QSF   YAGIF F+FWQ  +W+
Sbjct: 79  DISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL-MVQSFSHQYAGIFRFRFWQCGQWV 137

Query: 143 DVVIDDRLPTFRDRLVFLHSADHN-EFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
           +VVIDDRLP   D+ +F+     N EFW  LLEKAYAKL GSY  L  G   +A+ D TG
Sbjct: 138 EVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTG 197

Query: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCF-----IDTRSAAESEARTPFGLIKGHAY 256
           GV        +P +  + ++ A K GSL+ C       DT  A E+      GL+  HAY
Sbjct: 198 GVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMEN------GLVSLHAY 251

Query: 257 SVTGIDQVSFRGQRIELIRIRNP--WGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDD 314
           +VTG +Q+ +R    E+I + NP  WG+ EW G WSD S EW       + +L H   +D
Sbjct: 252 TVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQL-HKKRED 310

Query: 315 GEFWMAFKDFKAHFDKVEICNLTPDALEE-DAIHK-WEVTVHQGSWVRGSTAGGCRNFLD 372
           GEFWM+ +DF+  F  + IC+  P  L+  + +H+ W   + +   + G+TAGG RN   
Sbjct: 311 GEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN--- 367

Query: 373 TFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLK----RFGANVLTIGYAIYECPDK 428
               + Q   S+ E  EG      +   +     K +         V+  G   +     
Sbjct: 368 ----DAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFR---- 419

Query: 429 DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSE 488
            E     FF    +  +S      R  +  + L PG Y+++  T    + A+F LRIF +
Sbjct: 420 -EKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLLRIFLK 476

Query: 489 KKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNA 548
                R +  + ++ +    K +P +  +++     ++F + A + +++ A +L+ +LN 
Sbjct: 477 MPDSDRHLSSHFNLRM----KGSPSEHGSQQ-----SIFNRYAQQRLDIDATQLQGLLNQ 527

Query: 549 VLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKS 608
            L           SL  C+++++LM+   NG+L+ +EF   W +L  + ++F +      
Sbjct: 528 ELLTGP--PGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQT-SP 584

Query: 609 GTMSTYELRTALK----AAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRV 664
           G + + +L  A++      G  +S  LL L+ LRY+D   ++ F   +  L+RLE  ++ 
Sbjct: 585 GVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKT 644

Query: 665 FQALSTKNKEFIHLNINEFIHLTM 688
           F+ LS K+ + ++L   E++ L M
Sbjct: 645 FRNLS-KDGKGLYLTEMEWMSLVM 667


>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score =  296 bits (758), Expect = 4e-80
 Identities = 178/511 (34%), Positives = 275/511 (53%), Gaps = 49/511 (9%)

Query: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATR 86
           Q +++++QEC++   LF D  F   N SLFY+       VWKRP +I  +P  I+G  + 
Sbjct: 11  QKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIVGNISN 70

Query: 87  TDICQGELGDCWLLAAIASLTLNQKALARVIP--QDQSFGPG----YAGIFHFQFWQHSE 140
             + QG LG   +++A + L + +    + IP  ++Q + P     YAGIFHF+FW   E
Sbjct: 71  HQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGE 130

Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
           W +VVIDD LPT    LVF  S   NEFW+ALLEKAYAKL G YEAL G +  + + DFT
Sbjct: 131 WTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFT 190

Query: 201 GGVAETFQTK-----EAPENFYEI---LEKALKRGSLLGCFIDTRSAAESEARTPFGLIK 252
           G +AET   +     E  E  Y++   L K   +G L+ C I++ +  E E  T +GL+K
Sbjct: 191 GTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLK 250

Query: 253 GHAYSVTGIDQVS--------FRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQ 304
           GH Y++T I ++         F  +++ ++R+RNP G+ EW+G WS+ S EW+ +  +++
Sbjct: 251 GHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDR 310

Query: 305 KRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRG--- 361
           K L     DDGEFWM+ +DF  +F K+ +C      +      + E+    G W      
Sbjct: 311 KNLGLVMSDDGEFWMSLEDFCRNFHKLNVCR----NVNNPIFGRKELESVLGCWTVDDDP 366

Query: 362 --STAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFG-ANVLTI 418
             + +GGC N  DTF  NPQ   ++ E          +++L QKD R  +R G  +   I
Sbjct: 367 LMNRSGGCYNNRDTFLQNPQYIFTVPEDGH-----KVIMSLQQKDLRTYRRMGRPDNYII 421

Query: 419 GYAIYECPDKDEHLNKDFFRYH---ASRARSKTFINLREVSDRFKLPPGEYILIPSTFEP 475
           G+ +++       +N+ F  +H     RA + T+I+ R V     L  G Y+L+P+ F+ 
Sbjct: 422 GFELFKV-----EMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQH 476

Query: 476 HQEADFCLRIFSEKKAITRDMDGNVDIDLPE 506
            + ++F LRIFSE     R++     +D+P+
Sbjct: 477 GRTSEFLLRIFSEVPVQLREL----TLDMPK 503


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score =  270 bits (689), Expect = 4e-72
 Identities = 130/302 (43%), Positives = 189/302 (62%), Gaps = 43/302 (14%)

Query: 430 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 489
           +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+++PST+EPHQE +F LR+FSEK
Sbjct: 6   QHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEK 65

Query: 490 KAITRDMDGNVDIDLPEPPKPTPP------------------------------------ 513
           + ++ +++  + +D P   K T P                                    
Sbjct: 66  RNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSP 125

Query: 514 -------DQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISC 566
                  DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC
Sbjct: 126 QPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESC 185

Query: 567 KNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQ 626
           +++I+LMDT G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF 
Sbjct: 186 RSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFH 245

Query: 627 LSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHL 686
           L++ L  +I +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ L
Sbjct: 246 LNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQL 305

Query: 687 TM 688
           TM
Sbjct: 306 TM 307


>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score =  202 bits (515), Expect = 6e-52
 Identities = 151/491 (30%), Positives = 227/491 (46%), Gaps = 61/491 (12%)

Query: 42  LFEDADFPASNSSLFYS-ERPQIPF----VWKRPGEIVKNPEFILGGATRTDICQGELGD 96
           LF DA FPA++SSLF     P   F     W+RP EI   P           + QG LGD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 97  CWLLAAIASLTLNQKALARVIPQDQSFGPG--YAGIFHFQFWQHSEWLDVVIDDRLPTFR 154
           CW L A A+L  ++  L +VIP  Q       Y G F  + WQ   W++V  DDRLP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 155 DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTK---- 210
            RL F      + FW  LLEK YAK++GSYE L  G   +A+ D TGG+AE +  K    
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192

Query: 211 -----EAPENF-----YEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260
                + P  +      ++L   LK   L+ C + +  A   E      L + HA+ V+ 
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLH--LKDQCLISCCVLSPRAGARE------LGEFHAFIVSD 244

Query: 261 IDQVSFR-GQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWM 319
           + ++  + GQ I L+RI+NPWG+  W G W +    W  V  A    L  + L +GEFW+
Sbjct: 245 LRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELL-SQLQEGEFWV 303

Query: 320 AFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVH----QGSWVRGSTAGGCRNFLDTFW 375
             ++F   FD++ +     +A    +++   +  H     G+WV+G +AGGCRN    F 
Sbjct: 304 EEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFP 362

Query: 376 TNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTI------GYAIYECPDKD 429
           +NP+  L ++E  E        +A++Q+ R     +      +       ++    P K 
Sbjct: 363 SNPKFWLRVSEPSE------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKH 416

Query: 430 -EHLNKDFFRYHASRARSKTFINL------------REVSDRFKLPPGEYILIPSTFEPH 476
            + +    ++    R      +++            REV  R +L PG Y+ +PSTF   
Sbjct: 417 YQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKD 476

Query: 477 QEADFCLRIFS 487
              +F LR+FS
Sbjct: 477 APGEFLLRVFS 487



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 40/138 (28%), Positives = 56/138 (40%), Gaps = 8/138 (5%)

Query: 348 KWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRK 407
           +W     +GSW  G TAGG RNF  ++ TNP    S+    EG       + L Q  R  
Sbjct: 513 EWGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV---PEGPGPRCVRITLHQHCRPS 568

Query: 408 LKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 467
              F      IG+ I++ P+     +                   +EVS    LP G Y 
Sbjct: 569 DTEFH----PIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYK 624

Query: 468 LIPSTFEPHQEADFCLRI 485
           ++PST+ P  E  F + I
Sbjct: 625 VVPSTYLPDTEGAFTVTI 642


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  195 bits (496), Expect = 1e-49
 Identities = 148/491 (30%), Positives = 221/491 (45%), Gaps = 63/491 (12%)

Query: 42  LFEDADFPASNSSLFYS-ERPQIPF----VWKRPGEIVKNPEFILGGATRTDICQGELGD 96
           LF DA FPA++SSLF     P   F     W+RP EI   P           + QG LGD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 97  CWLLAAIASLTLNQKALARVIPQDQSFGPG--YAGIFHFQFWQHSEWLDVVIDDRLPTFR 154
           CW L A A+L  ++  L +VIP  Q       Y G F  + WQ   W++V  DDRLP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 155 DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTK---- 210
            RL F      + FW  LLEK YAK++GSYE L  G   +A+ D TGG+AE +  K    
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192

Query: 211 -----EAPENF-----YEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260
                + P  +      ++L   LK   L+ C + +  A   E      L + HA+ V+ 
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLH--LKDQCLISCCVLSPRAGARE------LGEFHAFIVSD 244

Query: 261 IDQVSFR-GQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWM 319
           + ++  + GQ I L+RI+NPWG+  W G W +    W  V  A    L  + L +GEFW+
Sbjct: 245 LRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELL-SQLQEGEFWV 303

Query: 320 AFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVH----QGSWVRGSTAGGCRNFLDTFW 375
             ++F   FD++ +     +A    +++   +  H     G+WV+G +AGGCRN    F 
Sbjct: 304 EEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFP 362

Query: 376 TNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRF---------------------GAN 414
           +NP+  L ++E  E        +A++Q+ R     +                     G +
Sbjct: 363 SNPKFWLRVSEPSE------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKH 416

Query: 415 VLTIGYAIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFE 474
              +G  +++ P+     +                   +EVS    LP G Y ++PST+ 
Sbjct: 417 YQAVGLHLWKVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYL 476

Query: 475 PHQEADFCLRI 485
           P  E  F + I
Sbjct: 477 PDTEGAFTVTI 487


>gi|14161692 calpain small subunit 2 [Homo sapiens]
          Length = 248

 Score =  166 bits (419), Expect = 9e-41
 Identities = 84/189 (44%), Positives = 126/189 (66%), Gaps = 8/189 (4%)

Query: 508 PKPTPPDQ--------ETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFK 559
           P+P P  Q        E+EE +RFR  F Q+AG DMEV A +L  +LN VL K KD+K  
Sbjct: 58  PEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTD 117

Query: 560 KLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTA 619
             SL +C++I+S+MD+   GKL F+EFK  W+ +K+W  ++ ++D D SG++ + +LR A
Sbjct: 118 GFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGA 177

Query: 620 LKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLN 679
           L+AAGFQL+  L Q+IV RYA+E+  +DF++F++CLVRL+   R F++L       I ++
Sbjct: 178 LQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVS 237

Query: 680 INEFIHLTM 688
           I E++ LTM
Sbjct: 238 IKEWLQLTM 246


>gi|4502565 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  165 bits (417), Expect = 1e-40
 Identities = 80/189 (42%), Positives = 124/189 (65%), Gaps = 5/189 (2%)

Query: 505 PEPPKPTP-----PDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFK 559
           PEPP P          E+EE ++FR LF Q+AG+DMEV+A EL  +LN V+ +  D+K  
Sbjct: 78  PEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTD 137

Query: 560 KLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTA 619
              + +C++++++MD+   GKL F+EFK  W+ +K+W  ++ +FD D+SGT+ + EL  A
Sbjct: 138 GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGA 197

Query: 620 LKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLN 679
            +AAGF L+ HL  +I+ RY+DE   +DFD+F++CLVRL+   R F++L       I +N
Sbjct: 198 FEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVN 257

Query: 680 INEFIHLTM 688
           I E++ LTM
Sbjct: 258 IQEWLQLTM 266


>gi|51599151 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  165 bits (417), Expect = 1e-40
 Identities = 80/189 (42%), Positives = 124/189 (65%), Gaps = 5/189 (2%)

Query: 505 PEPPKPTP-----PDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFK 559
           PEPP P          E+EE ++FR LF Q+AG+DMEV+A EL  +LN V+ +  D+K  
Sbjct: 78  PEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTD 137

Query: 560 KLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTA 619
              + +C++++++MD+   GKL F+EFK  W+ +K+W  ++ +FD D+SGT+ + EL  A
Sbjct: 138 GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGA 197

Query: 620 LKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLN 679
            +AAGF L+ HL  +I+ RY+DE   +DFD+F++CLVRL+   R F++L       I +N
Sbjct: 198 FEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVN 257

Query: 680 INEFIHLTM 688
           I E++ LTM
Sbjct: 258 IQEWLQLTM 266


>gi|27765080 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  150 bits (380), Expect = 3e-36
 Identities = 70/154 (45%), Positives = 102/154 (66%)

Query: 535 MEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLK 594
           ME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMDT G+GKL   EF   W+K+K
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 595 QWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNC 654
            W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +I +RYAD+ + +DFD F+ C
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 655 LVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 688
            VRLE   R F A        I LN+ E++ LTM
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 154


>gi|27765078 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  150 bits (380), Expect = 3e-36
 Identities = 70/154 (45%), Positives = 102/154 (66%)

Query: 535 MEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLK 594
           ME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMDT G+GKL   EF   W+K+K
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 595 QWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNC 654
            W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +I +RYAD+ + +DFD F+ C
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 655 LVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 688
            VRLE   R F A        I LN+ E++ LTM
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 154


>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score =  145 bits (367), Expect = 9e-35
 Identities = 129/460 (28%), Positives = 188/460 (40%), Gaps = 64/460 (13%)

Query: 36  CLQRGTLFEDADFPASNSSLFYSERPQIPF---VWKRPGEIV-------KNPEFILGGAT 85
           C +    F D  FP    S+ +     +      W RP EI        +    +     
Sbjct: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540

Query: 86  RTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVV 145
            +DI QG LG+CW L+A+A L      + RV+        G    +  +  +   W  V+
Sbjct: 541 PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEG---AYQVRLCKDGTWTTVL 597

Query: 146 IDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAE 205
           +DD LP      +    A   + W AL+EKA AKL+GSY AL+ G AIE +   TG   E
Sbjct: 598 VDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCE 657

Query: 206 TF-------QTKEAPENFYEILEKAL---KRGSLLGCFI-DTRSAAESEARTPFGLIKGH 254
           +          +E P +   I  K L   + G L+G          +  A    GL   H
Sbjct: 658 SLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRH 717

Query: 255 AYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDD 314
           AYS+  +  V    Q   L+R+RNPWG+  WNGSWSD  P W   G    + + H +  +
Sbjct: 718 AYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW--PGHLRGELMPHGS-SE 770

Query: 315 GEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTF 374
           G FWM + DF  +FD V+IC +  D         W+    QG +   ++A          
Sbjct: 771 GVFWMEYGDFVRYFDSVDICKVHSD---------WQEARVQGCFPSSASA---------- 811

Query: 375 WTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECP-DKDEHLN 433
              P    +LT      E  S   AL Q+  R+     +++L +   ++        HL+
Sbjct: 812 ---PVGVTALTV----LERASLEFALFQEGSRRSDAVDSHLLDLCILVFRATFGSGGHLS 864

Query: 434 KDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTF 473
                 H+ RA  K       VS    L PGEY ++   F
Sbjct: 865 LGRLLAHSKRAVKKF------VSCDVMLEPGEYAVVCCAF 898


>gi|38679884 sorcin isoform b [Homo sapiens]
          Length = 183

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 52/164 (31%), Positives = 89/164 (54%), Gaps = 4/164 (2%)

Query: 527 FEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEF 586
           F  VAG+D ++ A+EL+  L    Q      +K  +L +C+ ++S++D   +G + F+EF
Sbjct: 24  FAAVAGQDGQIDADELQRCLT---QSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEF 80

Query: 587 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 646
           K  W  L  W   F+ FD D+SGT+   EL+ AL   GF+LS   +  I  RY+    ++
Sbjct: 81  KELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNG-KI 139

Query: 647 DFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI 690
            FDD++ C V+L   +  F+   T  +  ++   ++FI   M++
Sbjct: 140 TFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 183


>gi|4507207 sorcin isoform a [Homo sapiens]
          Length = 198

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 52/164 (31%), Positives = 89/164 (54%), Gaps = 4/164 (2%)

Query: 527 FEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEF 586
           F  VAG+D ++ A+EL+  L    Q      +K  +L +C+ ++S++D   +G + F+EF
Sbjct: 39  FAAVAGQDGQIDADELQRCLT---QSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEF 95

Query: 587 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 646
           K  W  L  W   F+ FD D+SGT+   EL+ AL   GF+LS   +  I  RY+    ++
Sbjct: 96  KELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNG-KI 154

Query: 647 DFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI 690
            FDD++ C V+L   +  F+   T  +  ++   ++FI   M++
Sbjct: 155 TFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 198


>gi|7656959 calpain 7 [Homo sapiens]
          Length = 813

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 78/285 (27%), Positives = 135/285 (47%), Gaps = 31/285 (10%)

Query: 67  WKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIA-----SLTLNQKALARVI-PQD 120
           W RP ++  NP  I    +   I Q  + DC  +A++A         N+K +  +I PQ+
Sbjct: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319

Query: 121 QSFGPGYAGIFHFQFWQHSEWLD--VVIDDRLPT-FRDRLVFLHSADHNEFWSALLEKAY 177
           +   P Y     +    H   +   V+IDD+LP   +  L+  +S + +E W +L+EKAY
Sbjct: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379

Query: 178 AKLNGSYEALKGGSAIEAMEDFTGGVAETF------QTKEAPENFYEILEKALKRGSLLG 231
            K+ G Y+     S I+ +   TG + E        QT     +F  + ++  K   L+ 
Sbjct: 380 MKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLIT 438

Query: 232 CFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSD 291
                 + AE E    +GL+  HAY+V  +D   F+G R   I+++NPW  + W G +S+
Sbjct: 439 ASTGMMTEAEGE---KWGLVPTHAYAV--LDIREFKGLR--FIQLKNPWSHLRWKGRYSE 491

Query: 292 SSPEWRSVGPAEQKRL-----CHTALDDGEFWMAFKDFKAHFDKV 331
           +  + ++  P  QK L         +D+G FW+++ D   ++D +
Sbjct: 492 N--DVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVI 534


>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
           sapiens]
          Length = 217

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 55/164 (33%), Positives = 87/164 (53%), Gaps = 4/164 (2%)

Query: 527 FEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEF 586
           F  VAG+D EV AEEL+  L    Q   +  +   SL +C+ +I+++D    GK+ F+ F
Sbjct: 58  FSAVAGQDGEVDAEELQRCLT---QSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAF 114

Query: 587 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 646
           K  W  L  W   F+  D D SGT+  +ELR A+   G++LS   L  IV RY+ +  ++
Sbjct: 115 KELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYS-KNGRI 173

Query: 647 DFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI 690
            FDD++ C V+L   +  F+      +   +   ++F+  TM I
Sbjct: 174 FFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI 217


>gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]
          Length = 284

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 37/125 (29%), Positives = 67/125 (53%), Gaps = 2/125 (1%)

Query: 565 SCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAG 624
           +C  +I++ D + +G+++   F   W  ++QW NLF ++D D+SG++S  EL+ AL   G
Sbjct: 155 TCLMMINMFDKTKSGRIDVYGFSALWKFIQQWKNLFQQYDRDRSGSISYTELQQALSQMG 214

Query: 625 FQLSSHLLQLIVLRYADEELQ--LDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINE 682
           + LS    QL+V RY        +  D F+    +L+  +  F+   T  +  I L+  +
Sbjct: 215 YNLSPQFTQLLVSRYCPRSANPAMQLDRFIQVCTQLQVLTEAFREKDTAVQGNIRLSFED 274

Query: 683 FIHLT 687
           F+ +T
Sbjct: 275 FVTMT 279


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,129,419
Number of Sequences: 37866
Number of extensions: 1336429
Number of successful extensions: 4443
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 4220
Number of HSP's gapped (non-prelim): 123
length of query: 690
length of database: 18,247,518
effective HSP length: 109
effective length of query: 581
effective length of database: 14,120,124
effective search space: 8203792044
effective search space used: 8203792044
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.