Search of human proteins with 47078247

Search of human proteins with 47078247

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47078247 calpain 3 isoform f [Homo sapiens]
         (728 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47078247 calpain 3 isoform f [Homo sapiens]                       1512   0.0  
gi|27765072 calpain 3 isoform b [Homo sapiens]                       1480   0.0  
gi|4557405 calpain 3 isoform a [Homo sapiens]                        1473   0.0  
gi|27765074 calpain 3 isoform c [Homo sapiens]                       1267   0.0  
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                         730   0.0  
gi|12408656 calpain 1, large subunit [Homo sapiens]                   717   0.0  
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                         695   0.0  
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       676   0.0  
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       675   0.0  
gi|215490104 calpain 11 [Homo sapiens]                                647   0.0  
gi|221554549 calpain 8 [Homo sapiens]                                 617   e-177
gi|27765076 calpain 3 isoform d [Homo sapiens]                        615   e-176
gi|38707981 calpain 12 [Homo sapiens]                                 454   e-127
gi|223468608 calpain 14 [Homo sapiens]                                408   e-113
gi|37577157 calpain 5 [Homo sapiens]                                  330   4e-90
gi|27765080 calpain 3 isoform e [Homo sapiens]                        329   5e-90
gi|27765078 calpain 3 isoform e [Homo sapiens]                        329   5e-90
gi|41152101 calpain 13 [Homo sapiens]                                 284   2e-76
gi|13186316 calpain 6 [Homo sapiens]                                  251   2e-66
gi|4502565 calpain, small subunit 1 [Homo sapiens]                    224   2e-58
gi|51599151 calpain, small subunit 1 [Homo sapiens]                   224   2e-58
gi|14161692 calpain small subunit 2 [Homo sapiens]                    210   4e-54
gi|13186302 calpain 10 isoform a [Homo sapiens]                       199   8e-51
gi|89353291 calpain 10 isoform c [Homo sapiens]                       192   7e-49
gi|5032105 small optic lobes [Homo sapiens]                           144   2e-34
gi|38679884 sorcin isoform b [Homo sapiens]                           102   1e-21
gi|4507207 sorcin isoform a [Homo sapiens]                            102   1e-21
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap...    97   7e-20
gi|7019485 programmed cell death 6 [Homo sapiens]                      81   4e-15
gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]            76   1e-13

>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score = 1512 bits (3914), Expect = 0.0
 Identities = 728/728 (100%), Positives = 728/728 (100%)

Query: 1   MSWQISLKTQTTQQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFR 60
           MSWQISLKTQTTQQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFR
Sbjct: 1   MSWQISLKTQTTQQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFR 60

Query: 61  VIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEK 120
           VIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEK
Sbjct: 61  VIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEK 120

Query: 121 AYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSID 180
           AYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSID
Sbjct: 121 AYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSID 180

Query: 181 DGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMA 240
           DGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMA
Sbjct: 181 DGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMA 240

Query: 241 CGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARL 300
           CGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARL
Sbjct: 241 CGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARL 300

Query: 301 QHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGC 360
           QHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGC
Sbjct: 301 QHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGC 360

Query: 361 RNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIY 420
           RNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIY
Sbjct: 361 RNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIY 420

Query: 421 EVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEG 480
           EVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEG
Sbjct: 421 EVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEG 480

Query: 481 EFILRVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQ 540
           EFILRVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQ
Sbjct: 481 EFILRVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQ 540

Query: 541 KQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFT 600
           KQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFT
Sbjct: 541 KQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFT 600

Query: 601 LESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVND 660
           LESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVND
Sbjct: 601 LESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVND 660

Query: 661 AGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLE 720
           AGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLE
Sbjct: 661 AGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLE 720

Query: 721 WLQLTMYA 728
           WLQLTMYA
Sbjct: 721 WLQLTMYA 728


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score = 1480 bits (3831), Expect = 0.0
 Identities = 712/712 (100%), Positives = 712/712 (100%)

Query: 17  EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 76
           EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF
Sbjct: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163

Query: 77  HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 136
           HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN
Sbjct: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223

Query: 137 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 196
           TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM
Sbjct: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 283

Query: 197 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 256
           GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE
Sbjct: 284 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 343

Query: 257 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 316
           VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED
Sbjct: 344 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 403

Query: 317 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 376
           FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK
Sbjct: 404 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463

Query: 377 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 436
           LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD
Sbjct: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 523

Query: 437 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 496
           FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE
Sbjct: 524 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 583

Query: 497 VENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE 556
           VENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE
Sbjct: 584 VENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE 643

Query: 557 EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS 616
           EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS
Sbjct: 644 EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS 703

Query: 617 GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR 676
           GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR
Sbjct: 704 GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR 763

Query: 677 YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728
           YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 764 YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 815


>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score = 1473 bits (3814), Expect = 0.0
 Identities = 712/718 (99%), Positives = 712/718 (99%), Gaps = 6/718 (0%)

Query: 17  EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 76
           EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF
Sbjct: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163

Query: 77  HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 136
           HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN
Sbjct: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223

Query: 137 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 196
           TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM
Sbjct: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 283

Query: 197 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 256
           GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE
Sbjct: 284 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 343

Query: 257 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 316
           VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED
Sbjct: 344 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 403

Query: 317 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 376
           FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK
Sbjct: 404 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463

Query: 377 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 436
           LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD
Sbjct: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 523

Query: 437 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 496
           FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE
Sbjct: 524 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 583

Query: 497 VENTISVDRPV------PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS 550
           VENTISVDRPV      PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS
Sbjct: 584 VENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS 643

Query: 551 SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIAL 610
           SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIAL
Sbjct: 644 SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIAL 703

Query: 611 MDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLY 670
           MDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLY
Sbjct: 704 MDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLY 763

Query: 671 DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728
           DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 764 DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score = 1267 bits (3279), Expect = 0.0
 Identities = 626/712 (87%), Positives = 626/712 (87%), Gaps = 86/712 (12%)

Query: 17  EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 76
           EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF
Sbjct: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163

Query: 77  HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 136
           HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN
Sbjct: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223

Query: 137 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 196
           TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSID                
Sbjct: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSID---------------- 267

Query: 197 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 256
                                           TIIPVQYETRMACGLVRGHAYSVTGLDE
Sbjct: 268 --------------------------------TIIPVQYETRMACGLVRGHAYSVTGLDE 295

Query: 257 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 316
           VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED
Sbjct: 296 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 355

Query: 317 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 376
           FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK
Sbjct: 356 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 415

Query: 377 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 436
           LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD
Sbjct: 416 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 475

Query: 437 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 496
           FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE
Sbjct: 476 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 535

Query: 497 VENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE 556
           VENTISVDRPV                                      PQPGSSDQESE
Sbjct: 536 VENTISVDRPV--------------------------------------PQPGSSDQESE 557

Query: 557 EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS 616
           EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS
Sbjct: 558 EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS 617

Query: 617 GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR 676
           GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR
Sbjct: 618 GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR 677

Query: 677 YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728
           YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 678 YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score =  730 bits (1884), Expect = 0.0
 Identities = 357/714 (50%), Positives = 476/714 (66%), Gaps = 93/714 (13%)

Query: 13  QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY 72
           ++  EI +NP FI+ GA RTDICQGELGDCW LAAIA LTLNQ  L RVIP DQSF   Y
Sbjct: 68  KRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGY 127

Query: 73  AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEAL 132
           AGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S   NEFWSALLEKAYAKL+GSYEAL
Sbjct: 128 AGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEAL 187

Query: 133 KGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPS 192
           KGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA++RGSL+GC ID            
Sbjct: 188 KGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFID------------ 235

Query: 193 GLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVT 252
                                               T    + E R   GL++GHAYSVT
Sbjct: 236 ------------------------------------TRSAAESEARTPFGLIKGHAYSVT 259

Query: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312
           G+D+V F+G++++L+R+RNPWGQVEWNGSWSD   +W  V   E+ RL H   +DGEFWM
Sbjct: 260 GIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWM 319

Query: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQ 372
           +++DF  HF K+EICNLT DAL+ D +  W V+V++G WVRG +AGGCRNF DTFWTNPQ
Sbjct: 320 AFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQ 379

Query: 373 YRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQH 432
            +L L E+D+  ++    CSFLVALMQK+RRK ++ GA++ TIG+AIYE P +     +H
Sbjct: 380 IKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK----DEH 431

Query: 433 LQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRN 492
           L KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+++PST+EPHQE +F LR+FSEK+ 
Sbjct: 432 LNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKA 491

Query: 493 LSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSD 552
           ++ +++  + +D P P                                     P+P   D
Sbjct: 492 ITRDMDGNVDIDLPEP-------------------------------------PKPTPPD 514

Query: 553 QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMD 612
           QE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMD
Sbjct: 515 QETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMD 574

Query: 613 TDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDI 672
           T G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +
Sbjct: 575 TSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQL 634

Query: 673 ITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 726
           I +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ LTM
Sbjct: 635 IVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 688


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  717 bits (1851), Expect = 0.0
 Identities = 358/720 (49%), Positives = 488/720 (67%), Gaps = 95/720 (13%)

Query: 13  QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY 72
           ++  E+  NP+FI+DGA RTDICQG LGDCW LAAIA LTLN  LL RV+PH QSF   Y
Sbjct: 86  KRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGY 145

Query: 73  AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEAL 132
           AGIFHFQ W++GEWVDVV+DD LP  + +LVF  S   NEFWSALLEKAYAK++GSYEAL
Sbjct: 146 AGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEAL 205

Query: 133 KGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPS 192
            GG+T+E  EDFTGGV E++E+R APSD+Y+I+ KA+ERGSL+GC               
Sbjct: 206 SGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGC--------------- 250

Query: 193 GLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVT 252
                        ++D S + D +                + ++      LV+GHAYSVT
Sbjct: 251 -------------SIDISSVLDMEA---------------ITFKK-----LVKGHAYSVT 277

Query: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312
           G  +V ++G+ V L+R+RNPWG+VEW G+WSD   +W+ VD  E+ +L+ ++ EDGEFWM
Sbjct: 278 GAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKM-EDGEFWM 336

Query: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQ 372
           S+ DF+  FT+LEICNLT DAL+S  ++ W  ++ EG W RG +AGGCRN+P TFW NPQ
Sbjct: 337 SFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQ 396

Query: 373 YRLKLLEEDDDPD---DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGN 429
           ++++ L+E DDPD   D E  CSF++ALMQK+RR++R+ G  + TIGFA+YEVP E+ G 
Sbjct: 397 FKIR-LDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQ 455

Query: 430 KQ-HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFS 488
              HL++DFFL NAS+ARS+ +IN+REVS RFRLPP EYV+VPST+EP++EG+F+LR FS
Sbjct: 456 PAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFS 515

Query: 489 EKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQP 548
           EK   + E+++ I  +                                PD+Q  S     
Sbjct: 516 EKSAGTVELDDQIQAN-------------------------------LPDEQVLS----- 539

Query: 549 GSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMI 608
                E E  + F+ +F+Q+AG+DMEI   EL+ +LN +++KHKDL+T GF+LESCRSM+
Sbjct: 540 -----EEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMV 594

Query: 609 ALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQ 668
            LMD DG+GKL L EF+ LWN+I+ +  IF+ +D D+SG++++YEMR A+  AGF LN +
Sbjct: 595 NLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKK 654

Query: 669 LYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728
           LY++I  RY++  + +DFD+F+CC VRLE MFR F   D D DG++  ++ +WLQLTM+A
Sbjct: 655 LYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score =  695 bits (1794), Expect = 0.0
 Identities = 347/714 (48%), Positives = 463/714 (64%), Gaps = 119/714 (16%)

Query: 13  QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY 72
           ++  EI +NP FI+ GA RTDICQGELGDCW LAAIA LTLNQ  L RVIP DQSF   Y
Sbjct: 68  KRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGY 127

Query: 73  AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEAL 132
           AGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S   NEFWSALLEKAYAKL+GSYEAL
Sbjct: 128 AGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEAL 187

Query: 133 KGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPS 192
           KGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA++RGSL+GC ID            
Sbjct: 188 KGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFID------------ 235

Query: 193 GLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVT 252
                                               T    + E R   GL++GHAYSVT
Sbjct: 236 ------------------------------------TRSAAESEARTPFGLIKGHAYSVT 259

Query: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312
           G+D+V F+G++++L+R+RNPWGQVEWNGSWSDR                          M
Sbjct: 260 GIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR--------------------------M 293

Query: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQ 372
           +++DF  HF K+EICNLT DAL+ D +  W V+V++G WVRG +AGGCRNF DTFWTNPQ
Sbjct: 294 AFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQ 353

Query: 373 YRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQH 432
            +L L E+D+  ++    CSFLVALMQK+RRK ++ GA++ TIG+AIYE P +     +H
Sbjct: 354 IKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK----DEH 405

Query: 433 LQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRN 492
           L KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+++PST+EPHQE +F LR+FSEK+ 
Sbjct: 406 LNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKA 465

Query: 493 LSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSD 552
           ++ +++  + +D P P                                     P+P   D
Sbjct: 466 ITRDMDGNVDIDLPEP-------------------------------------PKPTPPD 488

Query: 553 QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMD 612
           QE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMD
Sbjct: 489 QETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMD 548

Query: 613 TDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDI 672
           T G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +
Sbjct: 549 TSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQL 608

Query: 673 ITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 726
           I +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ LTM
Sbjct: 609 IVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 662


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  676 bits (1744), Expect = 0.0
 Identities = 337/720 (46%), Positives = 470/720 (65%), Gaps = 94/720 (13%)

Query: 6   SLKTQTTQQKN--EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIP 63
           S KT+  + K   EIC +P+FII GA RTDICQG LGDCW LAAIA LTLN+ +L RV+P
Sbjct: 67  SSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVP 126

Query: 64  HDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYA 123
            +QSF ENYAGIFHFQFW+YGEWV+VV+DD LPT + +L+F  S   +EFWSALLEKAYA
Sbjct: 127 LNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYA 186

Query: 124 KLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGT 183
           K++G YEAL GG TTE  EDFTGG+AE++E++  P +++KI++KA+++GSL+GCSI    
Sbjct: 187 KINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI---- 242

Query: 184 NMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGL 243
                                   D +   DS+                + ++      L
Sbjct: 243 ------------------------DITSAADSEA---------------ITFQK-----L 258

Query: 244 VRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQ 303
           V+GHAYSVTG +EV   G   KL+R+RNPWG+VEW G W+D    W+ +D +E+ RL  +
Sbjct: 259 VKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR 318

Query: 304 VTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNF 363
             EDGEFWMS+ DF+ H+++LEICNLT D L SD  + W ++  +G W RG +AGGCRN+
Sbjct: 319 -HEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNY 377

Query: 364 PDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVP 423
           P+TFW NPQY +KL EED+D +D E  C+FLV L+QK+RR+ RK+G  + TIGF IYEVP
Sbjct: 378 PNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVP 437

Query: 424 KEMHGNKQ-HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEF 482
           +E+ G    HL K+FFL N ++ RS T+IN+REV  RF+LPP EY++VPST+EP+++G+F
Sbjct: 438 EELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDF 497

Query: 483 ILRVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQ 542
            +RVFSEK+   + V++ I  +               +E  +                  
Sbjct: 498 CIRVFSEKKADYQAVDDEIEANL--------------EEFDI------------------ 525

Query: 543 SPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLE 602
                      E +    FR +F Q+AG+D EI A EL+ +L  V+ K +D+K+ GF++E
Sbjct: 526 ----------SEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIE 575

Query: 603 SCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAG 662
           +C+ M+ ++D+DGSGKL L+EF+ LW KI+ +QKI++  D D+SGT+NSYEMR A+ +AG
Sbjct: 576 TCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAG 635

Query: 663 FHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 722
           F +  QL+ +I  R+AD  + IDFD+F+ C VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 636 FKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  675 bits (1742), Expect = 0.0
 Identities = 333/707 (47%), Positives = 464/707 (65%), Gaps = 92/707 (13%)

Query: 17  EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 76
           EIC +P+FII GA RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIF
Sbjct: 2   EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61

Query: 77  HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 136
           HFQFW+YGEWV+VV+DD LPT + +L+F  S   +EFWSALLEKAYAK++G YEAL GG 
Sbjct: 62  HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121

Query: 137 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 196
           TTE  EDFTGG+AE++E++  P +++KI++KA+++GSL+GCSI                 
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI----------------- 164

Query: 197 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 256
                      D +   DS+                + ++      LV+GHAYSVTG +E
Sbjct: 165 -----------DITSAADSEA---------------ITFQK-----LVKGHAYSVTGAEE 193

Query: 257 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 316
           V   G   KL+R+RNPWG+VEW G W+D    W+ +D +E+ RL  +  EDGEFWMS+ D
Sbjct: 194 VESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSD 252

Query: 317 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 376
           F+ H+++LEICNLT D L SD  + W ++  +G W RG +AGGCRN+P+TFW NPQY +K
Sbjct: 253 FLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIK 312

Query: 377 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQK 435
           L EED+D +D E  C+FLV L+QK+RR+ RK+G  + TIGF IYEVP+E+ G    HL K
Sbjct: 313 LEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSK 372

Query: 436 DFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSE 495
           +FFL N ++ RS T+IN+REV  RF+LPP EY++VPST+EP+++G+F +RVFSEK+   +
Sbjct: 373 NFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQ 432

Query: 496 EVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQES 555
            V++ I  +               +E  +                             E 
Sbjct: 433 AVDDEIEANL--------------EEFDI----------------------------SED 450

Query: 556 EEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDG 615
           +    FR +F Q+AG+D EI A EL+ +L  V+ K +D+K+ GF++E+C+ M+ ++D+DG
Sbjct: 451 DIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDG 510

Query: 616 SGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITM 675
           SGKL L+EF+ LW KI+ +QKI++  D D+SGT+NSYEMR A+ +AGF +  QL+ +I  
Sbjct: 511 SGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVA 570

Query: 676 RYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 722
           R+AD  + IDFD+F+ C VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 571 RFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 617


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  647 bits (1669), Expect = 0.0
 Identities = 340/719 (47%), Positives = 448/719 (62%), Gaps = 94/719 (13%)

Query: 13  QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY 72
           Q+  +I  NP FI+DG + TDICQG LGDCW LAAI  LT    LL+RV+P  QSF +NY
Sbjct: 110 QRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNY 169

Query: 73  AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEAL 132
           AGIFHFQ W++G+WV+VV+DD LPT N++LVF  S  R+EFWSALLEKAYAKL GSYEAL
Sbjct: 170 AGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEAL 229

Query: 133 KGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPS 192
            GG+T E +EDFTGGVA+ F+++  P ++ ++++KA+ER SLMGCSI+            
Sbjct: 230 SGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIE------------ 277

Query: 193 GLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVT 252
                             +  DS+L+   +D+                  LVRGHAYSVT
Sbjct: 278 ------------------VTSDSELESM-TDKM-----------------LVRGHAYSVT 301

Query: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312
           GL +V ++G+   L+R+RNPWG++EWNG+WSD  ++W  V  D + +L H+ TEDGEFWM
Sbjct: 302 GLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHK-TEDGEFWM 360

Query: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQ 372
           SY+DF+ +FT LEICNLT D L  D    W  +  EG W RG SAGGCRN P TFWTNPQ
Sbjct: 361 SYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQ 420

Query: 373 YRLKLLEEDDDPDDSE---VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGN 429
           +++ L E DD  DD+E   V+C+ LVALMQKN R  R+ GA L TIGF +Y VPKE    
Sbjct: 421 FKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNI 480

Query: 430 KQ-HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFS 488
           +  HL+K+FF        S+ + N REVS + RLPP EY+I+PST+EPH++ +F+LRVF+
Sbjct: 481 QDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFT 540

Query: 489 EKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQP 548
           EK + S E+                D  N  ++L  ++ SE+                  
Sbjct: 541 EKHSESWEL----------------DEVNYAEQLQEEKVSED------------------ 566

Query: 549 GSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMI 608
                  +  Q F ++FK +AG+  EI   EL+++LN +  K K  KT GF L++CR MI
Sbjct: 567 -------DMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMI 619

Query: 609 ALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQ 668
            LMD DGSGKL L EF  LW K+K W  IF+  D D SGT+NSYEMR  +  AG  LNN+
Sbjct: 620 NLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNK 679

Query: 669 LYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 727
           +  ++  RYAD  + IDFDSFI CF+RL+ MF  F   D    G I L++ +WLQ+TM+
Sbjct: 680 VMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  617 bits (1592), Expect = e-177
 Identities = 315/713 (44%), Positives = 439/713 (61%), Gaps = 93/713 (13%)

Query: 13  QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY 72
           ++  E+C +P+FI+ GA RTDICQG LGDCW LAAIA LTLN+ LL+RV+P DQ F ENY
Sbjct: 76  KRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENY 135

Query: 73  AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEAL 132
           AGIFHFQFW+YGEWV+VVIDD LPT N QL+F  S   NEFWSALLEKAYAKL+G YEAL
Sbjct: 136 AGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEAL 195

Query: 133 KGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPS 192
            GG+T E  EDFTGG+          S+ Y + K       ++  ++  G+ +      S
Sbjct: 196 AGGSTVEGFEDFTGGI----------SEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVS 245

Query: 193 GLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVT 252
                E I                                          LV+ HAYSVT
Sbjct: 246 SAAEAEAITSQK--------------------------------------LVKSHAYSVT 267

Query: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312
           G++EV F+G   KL+RLRNPWG+VEW+G+WSD   +W+ +D   K  L  +V EDGEFWM
Sbjct: 268 GVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKV-EDGEFWM 326

Query: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQ 372
           S  DF+  F++LEICNL+ D+L S+++  W + +  G W RG +AGGC+N+P T+WTNPQ
Sbjct: 327 SLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQ 386

Query: 373 YRLKLLEEDDDPDDS--EVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNK 430
           ++++L E D+D ++S  E  C+ L+ LMQKNRR  +++G  + +IG+A+Y+VPKE+  + 
Sbjct: 387 FKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHT 446

Query: 431 Q-HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSE 489
             HL +DFFL     AR+ TY+N+REVS R RLPP EY++VPST+EP ++GEF LRVFSE
Sbjct: 447 DAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSE 506

Query: 490 KRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPG 549
           K+  + E+ + ++                                          +P P 
Sbjct: 507 KKAQALEIGDVVA--------------------------------------GNPYEPHPS 528

Query: 550 SSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIA 609
             DQE +   QFR +F+++AG D EI A+ LK +LN   +K  D+K  GF + +CR MI+
Sbjct: 529 EVDQEDD---QFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMIS 585

Query: 610 LMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQL 669
           L+D++G+G L   EF  LW KI+ + +I+   D + SGTI+++EMR A+  AGF LN+Q+
Sbjct: 586 LLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQV 645

Query: 670 YDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 722
              I +RYA   + I+FDSF+ C +RLE +F+ F   D+D DG+++L++ EWL
Sbjct: 646 QQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score =  615 bits (1587), Expect = e-176
 Identities = 303/309 (98%), Positives = 303/309 (98%), Gaps = 6/309 (1%)

Query: 426 MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 485
           MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR
Sbjct: 1   MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 60

Query: 486 VFSEKRNLSEEVENTISVDRPV------PIIFVSDRANSNKELGVDQESEEGKGKTSPDK 539
           VFSEKRNLSEEVENTISVDRPV      PIIFVSDRANSNKELGVDQESEEGKGKTSPDK
Sbjct: 61  VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 120

Query: 540 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 599
           QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF
Sbjct: 121 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 180

Query: 600 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 659
           TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN
Sbjct: 181 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 240

Query: 660 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 719
           DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL
Sbjct: 241 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 300

Query: 720 EWLQLTMYA 728
           EWLQLTMYA
Sbjct: 301 EWLQLTMYA 309


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  454 bits (1168), Expect = e-127
 Identities = 263/738 (35%), Positives = 384/738 (52%), Gaps = 122/738 (16%)

Query: 16  NEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGI 75
           +E C  P+FI +  +RTD+CQG LG+CWFLAA A LTL   LL RV+P  Q F   YAG+
Sbjct: 79  HEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGV 138

Query: 76  FHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGG 135
           FHFQ W++G W+DVV+DD LP    +L+F +S  RNEFW+ LLEKAYAKLHGSYE ++GG
Sbjct: 139 FHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGG 198

Query: 136 NTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLN 195
           +  EA  DFTGGV E   +R     ++  ++ A+ + SL+G +                 
Sbjct: 199 HMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGATA---------------- 242

Query: 196 MGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLD 255
                                L  RG              E R   GLV+GHAYS+TG  
Sbjct: 243 ---------------------LSDRG--------------EYRTEEGLVKGHAYSITGTH 267

Query: 256 EVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYE 315
           +V     KV+L+RLRNPWG VEW G+WSD    W  +  + +  L  +  EDGEFWM   
Sbjct: 268 KVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVK-KEDGEFWMELR 326

Query: 316 DFIYHFTKLEICNLTADAL-QSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYR 374
           DF+ HF  ++IC+L+ + L  S +   W V   +GRWVRG ++GG +   +TFWTNPQ+R
Sbjct: 327 DFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQFR 386

Query: 375 LKLLEEDDDPDDSE---------------------VICSFLVALMQKNRRKDRKLGASLF 413
           L LLE D++ D+ E                       C+ L++L+Q+NRR+ R  G +  
Sbjct: 387 LTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYL 446

Query: 414 TIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPST 473
           T+GF ++++P+E+ G     +    L    +A        R+V++R  L P  Y++VPST
Sbjct: 447 TVGFHVFQIPEELLGLWDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPST 506

Query: 474 YEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKG 533
                E +F LRVFSE+R+ + E+++ IS D     +          ELG++Q       
Sbjct: 507 AHAGDEADFTLRVFSERRHTAVEIDDVISAD-----LQSLQGPYLPLELGLEQ------- 554

Query: 534 KTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKD 593
                                         +F+++AG++ E+ A +L+ +L+  +   + 
Sbjct: 555 ------------------------------LFQELAGEEEELNASQLQALLSIAL---EP 581

Query: 594 LKTHGFTLE--SCRSMIALMDTDGSGK-LNLQEFHHLWNKIKAWQKIFKHYDTDQSGTIN 650
            + H  T      R+   L+   G G+ L L  F  LW  +  WQ IF  +D D SGT+N
Sbjct: 582 ARAHTSTPREIGLRTCEQLLQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMN 641

Query: 651 SYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDG 710
           SYE+R A+N AGFHLNNQL   +T RY D  + +DF+ F+ C   L  +F         G
Sbjct: 642 SYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGG 701

Query: 711 DGIIKLNVLEWLQLTMYA 728
           +G+I L   +W+++  ++
Sbjct: 702 EGVICLTHRQWMEVATFS 719


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  408 bits (1048), Expect = e-113
 Identities = 256/717 (35%), Positives = 361/717 (50%), Gaps = 113/717 (15%)

Query: 17  EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 76
           E+  NP+F    A R D+CQG +GDCWFLAA+  L L+Q +L RV+P +QSF E YAGIF
Sbjct: 76  ELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIF 135

Query: 77  HFQFWRYGEWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGG 135
            F FW YG WV VVIDD LP     QLVF  S ++N FW ALLEKAYAKL GSYE L+ G
Sbjct: 136 RFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSG 195

Query: 136 NTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLN 195
             +EA+ DFTGGV                                    MT   + +  N
Sbjct: 196 QVSEALVDFTGGVT-----------------------------------MTINLAEAHGN 220

Query: 196 MGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQY---ETRMACGLVRGHAYSVT 252
           + +++     N                     RT+I  Q    E  +  GLV GHAY++T
Sbjct: 221 LWDILIEATYN---------------------RTLIGCQTHSGEKILENGLVEGHAYTLT 259

Query: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312
           G+ +V  K     LV+LRNPWG+VEW G WSD    W  +   EK  L  +   DGEFWM
Sbjct: 260 GIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRK-DNDGEFWM 318

Query: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRN-FPDTFWTNP 371
           + +DF  HF  L IC LT   L  +  Q WT ++ EGRW +  +AGG R    DTFW NP
Sbjct: 319 TLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNP 378

Query: 372 QYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ 431
           Q+ L +   ++        CS LV+L+QK R + RK    L  IGF +Y + K  H +++
Sbjct: 379 QFLLSVWRPEEGRRSLRP-CSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNK-YHDDQR 435

Query: 432 HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 491
            L  +FF  N   ++   ++  +EVSQ   L P  Y+IVP   E HQ+ EF+LRVFS K 
Sbjct: 436 RLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKH 495

Query: 492 NLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSS 551
              E   N+        ++F       +KE+                             
Sbjct: 496 IFYEIGSNS-------GVVF-------SKEI----------------------------E 513

Query: 552 DQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALM 611
           DQ   + + F   F++      EI A +L+ +LN +       +   F+LE+C+ ++AL+
Sbjct: 514 DQNERQDEFFTKFFEK----HPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALL 569

Query: 612 DTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYD 671
           D + SG +++QEF  LW ++K  QK+F H     SG +N  ++  A+ +AG  L++ +  
Sbjct: 570 DLNASGTMSIQEFRDLWKQLKLSQKVF-HKQDRGSGYLNWEQLHAAMREAGIMLSDDVCQ 628

Query: 672 IITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728
           ++ +RY    + +DF SFI   +R+E M   F    +DG GI  L   EW+ + +Y+
Sbjct: 629 LMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKGIY-LQKPEWMMMALYS 684


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  330 bits (845), Expect = 4e-90
 Identities = 194/500 (38%), Positives = 262/500 (52%), Gaps = 94/500 (18%)

Query: 18  ICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIEN 71
           ICE+PR  +DG +  D+ QG++G+CWF+AA + L   + L  +VIP       D      
Sbjct: 57  ICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNA 116

Query: 72  YAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEA 131
           YAGIFHF FWR+GEWVDVVIDD LPT NNQL++  SN RNEFW AL+EKAYAKL G Y+A
Sbjct: 117 YAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQA 176

Query: 132 LKGGNTTEAMEDFTGGVAEFFEIRDAP--------SDMYKIMKKAIERGSLMGCSIDDGT 183
           L GGNT +A+ DFTGGV+E  ++ +          + +++ M K   RG L+  SI    
Sbjct: 177 LDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASI---- 232

Query: 184 NMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGL 243
                                                       + +     E R+ACGL
Sbjct: 233 --------------------------------------------KAVTAADMEARLACGL 248

Query: 244 VRGHAYSVTGLDEVP--------FKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKD 295
           V+GHAY+VT + +V         FK EK+ ++RLRNPWG+ EWNG WSD  ++W  V K 
Sbjct: 249 VKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKS 308

Query: 296 EKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWV--- 352
           E+ ++   V +DGEFWM++ED   +FT +  C +   +  S   +TW  +   G W    
Sbjct: 309 EREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIH-KTWEEARLHGAWTLHE 367

Query: 353 --RGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG- 409
             R    GGC N  DTF+ NPQY    + E   P+D  +IC     + Q+ +R  R+ G 
Sbjct: 368 DPRQNRGGGCINHKDTFFQNPQY----IFEVKKPEDEVLIC-----IQQRPKRSTRREGK 418

Query: 410 ASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVI 469
                IGF IY+V +        LQ         KA S  YIN R V  R   P   YVI
Sbjct: 419 GENLAIGFDIYKVEENRQYRMHSLQ--------HKAASSIYINSRSVFLRTDQPEGRYVI 470

Query: 470 VPSTYEPHQEGEFILRVFSE 489
           +P+T+EP   GEF+LRVF++
Sbjct: 471 IPTTFEPGHTGEFLLRVFTD 490


>gi|27765080 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  329 bits (844), Expect = 5e-90
 Identities = 156/156 (100%), Positives = 156/156 (100%)

Query: 573 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 632
           MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 633 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 692
           AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 693 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728
           FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|27765078 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  329 bits (844), Expect = 5e-90
 Identities = 156/156 (100%), Positives = 156/156 (100%)

Query: 573 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 632
           MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 633 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 692
           AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 693 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728
           FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  284 bits (727), Expect = 2e-76
 Identities = 207/717 (28%), Positives = 328/717 (45%), Gaps = 132/717 (18%)

Query: 22  PRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFW 81
           P FI+D  +R DI QG   DCWFLAA+  LT N     +++   QSF   YAGIF F+FW
Sbjct: 73  PHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFW 131

Query: 82  RYGEWVDVVIDDCLPTYNNQLVFTKSNHRN-EFWSALLEKAYAKLHGSYEALKGGNTTEA 140
           + G+WV+VVIDD LP   ++ +F +  H+N EFW  LLEKAYAKL GSY  L  G   +A
Sbjct: 132 QCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDA 191

Query: 141 MEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELI 200
           + D TGGV     +  +P D+ K +K A + GSL+ C+           +PSG       
Sbjct: 192 LVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCA-----------TPSG------- 233

Query: 201 ARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK 260
                                          P      M  GLV  HAY+VTG +++ ++
Sbjct: 234 -------------------------------PTDTAQAMENGLVSLHAYTVTGAEQIQYR 262

Query: 261 GEKVKLVRLRNP--WGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFI 318
               +++ L NP  WG+ EW G WSD  ++W       K++L H+  EDGEFWMS +DF 
Sbjct: 263 RGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQL-HKKREDGEFWMSCQDFQ 321

Query: 319 YHFTKLEICNLTADALQSDKL--QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 376
             F  + IC+     L       + W+  +   + + G +AGG RN       + Q+   
Sbjct: 322 QKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-------DAQFNFS 374

Query: 377 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 436
           + E  +    + V+C  +       + +D K     F + F +     +    ++     
Sbjct: 375 VQEPME--GTNVVVCVTVAVTPSNLKAEDAK-----FPLDFQVILAGSQRF--REKFPPV 425

Query: 437 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 496
           FF    +  +S      R  +  + L P  YV+V  T    +  EF+LR+F +  +    
Sbjct: 426 FFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLLRIFLKMPDSDRH 483

Query: 497 VENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE 556
           + +  ++                                   + K SP          SE
Sbjct: 484 LSSHFNL-----------------------------------RMKGSP----------SE 498

Query: 557 EQQQFRNIFKQIAGDDMEICADELKKVLN--TVVNKHKDLKTHGFTLESCRSMIALMDTD 614
              Q ++IF + A   ++I A +L+ +LN   +     D+    F+L+ CRS++ALM+  
Sbjct: 499 HGSQ-QSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDM----FSLDECRSLVALMELK 553

Query: 615 GSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDA----GFHLNNQLY 670
            +G+L+ +EF  LW ++  +Q +F+   T   G + S ++  A+ +     G  ++ +L 
Sbjct: 554 VNGRLDQEEFARLWKRLVHYQHVFQKVQT-SPGVLLSSDLWKAIENTDFLRGIFISRELL 612

Query: 671 DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 727
            ++T+RY+D    + F S +C  +RLE M + F    KDG G+  L  +EW+ L MY
Sbjct: 613 HLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLY-LTEMEWMSLVMY 668


>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score =  251 bits (640), Expect = 2e-66
 Identities = 166/505 (32%), Positives = 250/505 (49%), Gaps = 95/505 (18%)

Query: 13  QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQ 66
           ++  +IC++P  I+   +   + QG LG    ++A +CL + +    + IP+      D 
Sbjct: 52  KRPQDICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDP 111

Query: 67  SFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLH 126
              E YAGIFHF+FW +GEW +VVIDD LPT N  LVF+ S   NEFW+ALLEKAYAKL 
Sbjct: 112 QKTEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLL 171

Query: 127 GSYEALKGGNTTEAMEDFTGGVAEFFEIR-----DAPSDMYKI---MKKAIERGSLMGCS 178
           G YEAL G   T+ + DFTG +AE  +++     +   + YK+   + K   +G L+ CS
Sbjct: 172 GCYEALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCS 231

Query: 179 IDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETR 238
           I+         SP+                                         + E  
Sbjct: 232 IE---------SPN---------------------------------------QEEQEVE 243

Query: 239 MACGLVRGHAYSVTGLDEV--------PFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWS 290
              GL++GH Y++T + ++         F  EKV +VRLRNP G+ EW+G WS+  ++W 
Sbjct: 244 TDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQ 303

Query: 291 FVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDK-----LQTWTVS 345
            +   ++  L   +++DGEFWMS EDF  +F KL +C    + +   K     L  WTV 
Sbjct: 304 QLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVD 363

Query: 346 VNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKD 405
            ++    R   +GGC N  DTF  NPQY   +      P+D   +   +++L QK+ R  
Sbjct: 364 -DDPLMNR---SGGCYNNRDTFLQNPQYIFTV------PEDGHKV---IMSLQQKDLRTY 410

Query: 406 RKLG-ASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPP 464
           R++G    + IGF +++V         H      LY   +A + TYI+ R V     L  
Sbjct: 411 RRMGRPDNYIIGFELFKVEMNRKFRLHH------LYIQERAGTSTYIDTRTVFLSKYLKK 464

Query: 465 SEYVIVPSTYEPHQEGEFILRVFSE 489
             YV+VP+ ++  +  EF+LR+FSE
Sbjct: 465 GNYVLVPTMFQHGRTSEFLLRIFSE 489


>gi|4502565 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  224 bits (572), Expect = 2e-58
 Identities = 106/192 (55%), Positives = 140/192 (72%), Gaps = 6/192 (3%)

Query: 543 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 596
           +P+P P  +        ESEE +QFR +F Q+AGDDME+ A EL  +LN VV +H DLKT
Sbjct: 77  NPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKT 136

Query: 597 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 656
            GF +++CRSM+A+MD+D +GKL  +EF +LWN IK WQ I+K +DTD+SGTI S E+  
Sbjct: 137 DGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPG 196

Query: 657 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 716
           A   AGFHLN  LY++I  RY+D+  N+DFD+FI C VRL+ MFRAF + DKDG G I++
Sbjct: 197 AFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQV 256

Query: 717 NVLEWLQLTMYA 728
           N+ EWLQLTMY+
Sbjct: 257 NIQEWLQLTMYS 268


>gi|51599151 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  224 bits (572), Expect = 2e-58
 Identities = 106/192 (55%), Positives = 140/192 (72%), Gaps = 6/192 (3%)

Query: 543 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 596
           +P+P P  +        ESEE +QFR +F Q+AGDDME+ A EL  +LN VV +H DLKT
Sbjct: 77  NPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKT 136

Query: 597 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 656
            GF +++CRSM+A+MD+D +GKL  +EF +LWN IK WQ I+K +DTD+SGTI S E+  
Sbjct: 137 DGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPG 196

Query: 657 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 716
           A   AGFHLN  LY++I  RY+D+  N+DFD+FI C VRL+ MFRAF + DKDG G I++
Sbjct: 197 AFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQV 256

Query: 717 NVLEWLQLTMYA 728
           N+ EWLQLTMY+
Sbjct: 257 NIQEWLQLTMYS 268


>gi|14161692 calpain small subunit 2 [Homo sapiens]
          Length = 248

 Score =  210 bits (534), Expect = 4e-54
 Identities = 96/192 (50%), Positives = 140/192 (72%), Gaps = 6/192 (3%)

Query: 543 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 596
           +P+P P           ESEE ++FR  F Q+AG DME+ A +L  +LN V++KHKDLKT
Sbjct: 57  TPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKT 116

Query: 597 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 656
            GF+L++CRS++++MD+D +GKL  +EF +LWN IK WQ ++K YD D SG++ S ++R 
Sbjct: 117 DGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRG 176

Query: 657 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 716
           A+  AGF LN QLY +I  RYA++  ++DF++FI C VRL+ MFRAF + D+D DG+I++
Sbjct: 177 ALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQV 236

Query: 717 NVLEWLQLTMYA 728
           ++ EWLQLTMY+
Sbjct: 237 SIKEWLQLTMYS 248


>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score =  199 bits (506), Expect = 8e-51
 Identities = 156/504 (30%), Positives = 229/504 (45%), Gaps = 78/504 (15%)

Query: 11  TTQQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFI- 69
           T ++  EIC  PR   D      + QG LGDCWFL A A L  ++HLL +VIP  Q    
Sbjct: 42  TWRRPQEICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWA 101

Query: 70  -ENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGS 128
            + Y G F  + W++G WV+V  DD LP    +L F++    + FW  LLEK YAK+HGS
Sbjct: 102 DQEYRGSFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGS 161

Query: 129 YEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYG 188
           YE L  G   +A+ D TGG+A                    ER +L G +   G      
Sbjct: 162 YEHLWAGQVADALVDLTGGLA--------------------ERWNLKGVAGSGGQQ---- 197

Query: 189 TSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHA 248
               G        +++   D  L+    L PR                   A  L   HA
Sbjct: 198 -DRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAG-----------------ARELGEFHA 239

Query: 249 YSVTGLDEVPFK-GEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED 307
           + V+ L E+  + G+ + L+R++NPWG+  W G W +  + WS VD    + L  Q+ ++
Sbjct: 240 FIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQL-QE 298

Query: 308 GEFWMSYEDFIYHFTKLEICNLTADA-----LQSDKLQTWTVSVNEGRWVRGCSAGGCRN 362
           GEFW+  E+F+  F +L +     +A     L +++L   T ++  G WV+G SAGGCRN
Sbjct: 299 GEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRAL-PGAWVKGQSAGGCRN 357

Query: 363 FPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRK-LGASLFTIGFAIYE 421
               F +NP++ L++ E       SEV     +A++Q++R       G +   +G +   
Sbjct: 358 -NSGFPSNPKFWLRVSE------PSEV----YIAVLQRSRLHAADWAGRARALVGDSHTS 406

Query: 422 VPKEMHGNKQHLQKDFFLYNASKAR--------------SKTYINMREVSQRFRLPPSEY 467
                   K +      L+   K R              +  +   REV  R  L P  Y
Sbjct: 407 WSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYY 466

Query: 468 VIVPSTYEPHQEGEFILRVFSEKR 491
           + VPST+     GEF+LRVFS  R
Sbjct: 467 LAVPSTFLKDAPGEFLLRVFSTGR 490



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 43/145 (29%), Positives = 60/145 (41%), Gaps = 16/145 (11%)

Query: 342 WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKN 401
           W      G W  G +AGG RNF  ++ TNP +   +      P+     C   + L Q  
Sbjct: 514 WGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV------PEGPGPRC-VRITLHQHC 565

Query: 402 RRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFR 461
           R  D +       IGF I++VP+   G  Q       L          +   +EVS+   
Sbjct: 566 RPSDTEF----HPIGFHIFQVPEG--GRSQDAPP--LLLQEPLLSCVPHRYAQEVSRLCL 617

Query: 462 LPPSEYVIVPSTYEPHQEGEFILRV 486
           LP   Y +VPSTY P  EG F + +
Sbjct: 618 LPAGTYKVVPSTYLPDTEGAFTVTI 642


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  192 bits (489), Expect = 7e-49
 Identities = 154/505 (30%), Positives = 229/505 (45%), Gaps = 88/505 (17%)

Query: 11  TTQQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFI- 69
           T ++  EIC  PR   D      + QG LGDCWFL A A L  ++HLL +VIP  Q    
Sbjct: 42  TWRRPQEICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWA 101

Query: 70  -ENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGS 128
            + Y G F  + W++G WV+V  DD LP    +L F++    + FW  LLEK YAK+HGS
Sbjct: 102 DQEYRGSFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGS 161

Query: 129 YEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYG 188
           YE L  G   +A+ D TGG+A                    ER +L G +   G      
Sbjct: 162 YEHLWAGQVADALVDLTGGLA--------------------ERWNLKGVAGSGGQQ---- 197

Query: 189 TSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHA 248
               G        +++   D  L+    L PR                   A  L   HA
Sbjct: 198 -DRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAG-----------------ARELGEFHA 239

Query: 249 YSVTGLDEVPFK-GEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED 307
           + V+ L E+  + G+ + L+R++NPWG+  W G W +  + WS VD    + L  Q+ ++
Sbjct: 240 FIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQL-QE 298

Query: 308 GEFWMSYEDFIYHFTKLEICNLTADA-----LQSDKLQTWTVSVNEGRWVRGCSAGGCRN 362
           GEFW+  E+F+  F +L +     +A     L +++L   T ++  G WV+G SAGGCRN
Sbjct: 299 GEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRAL-PGAWVKGQSAGGCRN 357

Query: 363 FPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNR-------RKDRKL------- 408
               F +NP++ L++ E       SEV     +A++Q++R        + R L       
Sbjct: 358 -NSGFPSNPKFWLRVSE------PSEV----YIAVLQRSRLHAADWAGRARALVGDSHTS 406

Query: 409 -------GASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFR 461
                  G     +G  +++VP+   G  Q       L          +   +EVS+   
Sbjct: 407 WSPASIPGKHYQAVGLHLWKVPE--GGRSQDAPP--LLLQEPLLSCVPHRYAQEVSRLCL 462

Query: 462 LPPSEYVIVPSTYEPHQEGEFILRV 486
           LP   Y +VPSTY P  EG F + +
Sbjct: 463 LPAGTYKVVPSTYLPDTEGAFTVTI 487


>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score =  144 bits (364), Expect = 2e-34
 Identities = 99/311 (31%), Positives = 137/311 (44%), Gaps = 67/311 (21%)

Query: 32  TDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVI 91
           +DI QG LG+CWFL+A+A L     L+ RV+       E   G +  +  + G W  V++
Sbjct: 542 SDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQVRLCKDGTWTTVLV 598

Query: 92  DDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEF 151
           DD LP      +      R + W AL+EKA AKLHGSY AL+ G   E +   TG   E 
Sbjct: 599 DDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCES 658

Query: 152 FEI-------RDAPSDMYKIMKKAI---ERGSLMGCSIDDGTNMTYGTSPSGLNMGELIA 201
             +       R+ P D   I  K +   E G LMG S   G NM                
Sbjct: 659 LALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGG-NM---------------- 701

Query: 202 RMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKG 261
                +D+S  +   L PR                          HAYS+  + +V    
Sbjct: 702 ----KVDDSAYESLGLRPR--------------------------HAYSILDVRDV---- 727

Query: 262 EKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHF 321
           +  +L+RLRNPWG+  WNGSWSD W  W       +  L    + +G FWM Y DF+ +F
Sbjct: 728 QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PGHLRGELMPHGSSEGVFWMEYGDFVRYF 784

Query: 322 TKLEICNLTAD 332
             ++IC + +D
Sbjct: 785 DSVDICKVHSD 795


>gi|38679884 sorcin isoform b [Homo sapiens]
          Length = 183

 Score =  102 bits (255), Expect = 1e-21
 Identities = 57/181 (31%), Positives = 93/181 (51%), Gaps = 8/181 (4%)

Query: 548 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCR 605
           PG      + Q      F  +AG D +I ADEL++ L    +   +K      F LE+CR
Sbjct: 7   PGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCR 61

Query: 606 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 665
            M++++D D SG +   EF  LW  +  W++ F  +DTD+SGT++  E++ A+   GF L
Sbjct: 62  LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRL 121

Query: 666 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 725
           + Q  + I  RY+  +  I FD +I C V+L  +  +F   D    G++     +++Q  
Sbjct: 122 SPQAVNSIAKRYS-TNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCV 180

Query: 726 M 726
           M
Sbjct: 181 M 181


>gi|4507207 sorcin isoform a [Homo sapiens]
          Length = 198

 Score =  102 bits (255), Expect = 1e-21
 Identities = 57/181 (31%), Positives = 93/181 (51%), Gaps = 8/181 (4%)

Query: 548 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCR 605
           PG      + Q      F  +AG D +I ADEL++ L    +   +K      F LE+CR
Sbjct: 22  PGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCR 76

Query: 606 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 665
            M++++D D SG +   EF  LW  +  W++ F  +DTD+SGT++  E++ A+   GF L
Sbjct: 77  LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRL 136

Query: 666 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 725
           + Q  + I  RY+  +  I FD +I C V+L  +  +F   D    G++     +++Q  
Sbjct: 137 SPQAVNSIAKRYS-TNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCV 195

Query: 726 M 726
           M
Sbjct: 196 M 196


>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
           sapiens]
          Length = 217

 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 59/179 (32%), Positives = 88/179 (49%), Gaps = 4/179 (2%)

Query: 548 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSM 607
           P  SD  S         F  +AG D E+ A+EL++ L        +     F+LE+CR M
Sbjct: 41  PAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLT---QSGINGTYSPFSLETCRIM 97

Query: 608 IALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNN 667
           IA++D D +GK+    F  LW  + AW++ F   D D SGT+  +E+R A+   G+ L+ 
Sbjct: 98  IAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSP 157

Query: 668 QLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 726
           Q    I  RY+ K+  I FD ++ C V+L  +   F   D    G       ++LQ TM
Sbjct: 158 QTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215


>gi|7019485 programmed cell death 6 [Homo sapiens]
          Length = 191

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 51/187 (27%), Positives = 94/187 (50%), Gaps = 10/187 (5%)

Query: 541 KQSPQPQPGSSDQESEEQQQFR-NIFKQIAGDDMEICAD-ELKKVLNTVVNKHKDLKTHG 598
           +  P   PG +   +   Q F  N+F+++  D   + +D EL++ L+             
Sbjct: 7   RPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGT-------WTP 59

Query: 599 FTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAV 658
           F   + RS+I++ D +    +N  EF  +W  I  WQ +F+ YD D SG I+  E++ A+
Sbjct: 60  FNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQAL 119

Query: 659 NDAGFHLNNQLYDIITMRY-ADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLN 717
           +  G+ L++Q +DI+  ++       I FD FI   + L+ +   F  +D D DG I+++
Sbjct: 120 SGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVS 179

Query: 718 VLEWLQL 724
             ++L +
Sbjct: 180 YEQYLSM 186


>gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]
          Length = 284

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 39/129 (30%), Positives = 72/129 (55%), Gaps = 2/129 (1%)

Query: 599 FTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAV 658
           F  E+C  MI + D   SG++++  F  LW  I+ W+ +F+ YD D+SG+I+  E++ A+
Sbjct: 151 FNDETCLMMINMFDKTKSGRIDVYGFSALWKFIQQWKNLFQQYDRDRSGSISYTELQQAL 210

Query: 659 NDAGFHLNNQLYDIITMRYADKHMN--IDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 716
           +  G++L+ Q   ++  RY  +  N  +  D FI    +L+ +  AF   D    G I+L
Sbjct: 211 SQMGYNLSPQFTQLLVSRYCPRSANPAMQLDRFIQVCTQLQVLTEAFREKDTAVQGNIRL 270

Query: 717 NVLEWLQLT 725
           +  +++ +T
Sbjct: 271 SFEDFVTMT 279


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,808,879
Number of Sequences: 37866
Number of extensions: 1339316
Number of successful extensions: 5558
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 5240
Number of HSP's gapped (non-prelim): 279
length of query: 728
length of database: 18,247,518
effective HSP length: 110
effective length of query: 618
effective length of database: 14,082,258
effective search space: 8702835444
effective search space used: 8702835444
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.