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Search of human proteins with 4557405
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557405 calpain 3 isoform a [Homo sapiens]
(821 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557405 calpain 3 isoform a [Homo sapiens] 1702 0.0
gi|27765072 calpain 3 isoform b [Homo sapiens] 1684 0.0
gi|27765074 calpain 3 isoform c [Homo sapiens] 1476 0.0
gi|47078247 calpain 3 isoform f [Homo sapiens] 1473 0.0
gi|5729758 calpain 9 isoform 1 [Homo sapiens] 776 0.0
gi|12408656 calpain 1, large subunit [Homo sapiens] 743 0.0
gi|7705383 calpain 9 isoform 2 [Homo sapiens] 741 0.0
gi|157389005 calpain 2 isoform 1 [Homo sapiens] 700 0.0
gi|225703100 calpain 2 isoform 2 [Homo sapiens] 673 0.0
gi|215490104 calpain 11 [Homo sapiens] 671 0.0
gi|221554549 calpain 8 [Homo sapiens] 646 0.0
gi|27765076 calpain 3 isoform d [Homo sapiens] 634 0.0
gi|38707981 calpain 12 [Homo sapiens] 480 e-135
gi|223468608 calpain 14 [Homo sapiens] 444 e-124
gi|37577157 calpain 5 [Homo sapiens] 361 1e-99
gi|27765080 calpain 3 isoform e [Homo sapiens] 329 6e-90
gi|27765078 calpain 3 isoform e [Homo sapiens] 329 6e-90
gi|41152101 calpain 13 [Homo sapiens] 300 3e-81
gi|13186316 calpain 6 [Homo sapiens] 293 6e-79
gi|4502565 calpain, small subunit 1 [Homo sapiens] 224 2e-58
gi|51599151 calpain, small subunit 1 [Homo sapiens] 224 2e-58
gi|13186302 calpain 10 isoform a [Homo sapiens] 215 1e-55
gi|14161692 calpain small subunit 2 [Homo sapiens] 210 5e-54
gi|89353291 calpain 10 isoform c [Homo sapiens] 209 1e-53
gi|5032105 small optic lobes [Homo sapiens] 157 3e-38
gi|38679884 sorcin isoform b [Homo sapiens] 102 1e-21
gi|4507207 sorcin isoform a [Homo sapiens] 102 1e-21
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap... 97 8e-20
gi|7019485 programmed cell death 6 [Homo sapiens] 81 4e-15
gi|7656959 calpain 7 [Homo sapiens] 78 4e-14
>gi|4557405 calpain 3 isoform a [Homo sapiens]
Length = 821
Score = 1702 bits (4409), Expect = 0.0
Identities = 821/821 (100%), Positives = 821/821 (100%)
Query: 1 MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT
Sbjct: 1 MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
Query: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD
Sbjct: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
Query: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD
Sbjct: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
Query: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE
Sbjct: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
Query: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300
IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ
Sbjct: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300
Query: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360
DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW
Sbjct: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360
Query: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420
GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA
Sbjct: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420
Query: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF
Sbjct: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
Query: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540
LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM
Sbjct: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540
Query: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK 600
REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK
Sbjct: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK 600
Query: 601 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 660
PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ
Sbjct: 601 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 660
Query: 661 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 720
IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL
Sbjct: 661 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 720
Query: 721 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 780
WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD
Sbjct: 721 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 780
Query: 781 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 781 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
>gi|27765072 calpain 3 isoform b [Homo sapiens]
Length = 815
Score = 1684 bits (4362), Expect = 0.0
Identities = 815/821 (99%), Positives = 815/821 (99%), Gaps = 6/821 (0%)
Query: 1 MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT
Sbjct: 1 MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
Query: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD
Sbjct: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
Query: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD
Sbjct: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
Query: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE
Sbjct: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
Query: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300
IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ
Sbjct: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300
Query: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360
DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW
Sbjct: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360
Query: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420
GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA
Sbjct: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420
Query: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF
Sbjct: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
Query: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540
LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM
Sbjct: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540
Query: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK 600
REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV
Sbjct: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV------ 594
Query: 601 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 660
PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ
Sbjct: 595 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 654
Query: 661 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 720
IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL
Sbjct: 655 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 714
Query: 721 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 780
WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD
Sbjct: 715 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 774
Query: 781 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 775 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 815
>gi|27765074 calpain 3 isoform c [Homo sapiens]
Length = 729
Score = 1476 bits (3821), Expect = 0.0
Identities = 729/821 (88%), Positives = 729/821 (88%), Gaps = 92/821 (11%)
Query: 1 MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT
Sbjct: 1 MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
Query: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD
Sbjct: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
Query: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD
Sbjct: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
Query: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE
Sbjct: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
Query: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300
IRDAPSDMYKIMKKAIERGSLMGCSID
Sbjct: 241 IRDAPSDMYKIMKKAIERGSLMGCSID--------------------------------- 267
Query: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360
TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW
Sbjct: 268 ---------------TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 312
Query: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420
GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA
Sbjct: 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 372
Query: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF
Sbjct: 373 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 432
Query: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540
LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM
Sbjct: 433 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 492
Query: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK 600
REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV
Sbjct: 493 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV------ 546
Query: 601 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 660
PQPGSSDQESEEQQQFRNIFKQ
Sbjct: 547 --------------------------------------PQPGSSDQESEEQQQFRNIFKQ 568
Query: 661 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 720
IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL
Sbjct: 569 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 628
Query: 721 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 780
WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD
Sbjct: 629 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 688
Query: 781 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 689 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729
>gi|47078247 calpain 3 isoform f [Homo sapiens]
Length = 728
Score = 1473 bits (3814), Expect = 0.0
Identities = 712/718 (99%), Positives = 712/718 (99%), Gaps = 6/718 (0%)
Query: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163
EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF
Sbjct: 17 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 76
Query: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223
HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN
Sbjct: 77 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 136
Query: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 283
TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM
Sbjct: 137 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 196
Query: 284 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 343
GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE
Sbjct: 197 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 256
Query: 344 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 403
VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED
Sbjct: 257 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 316
Query: 404 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463
FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK
Sbjct: 317 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 376
Query: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 523
LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD
Sbjct: 377 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 436
Query: 524 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 583
FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE
Sbjct: 437 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 496
Query: 584 VENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS 643
VENTISVDRPV PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS
Sbjct: 497 VENTISVDRPV------PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS 550
Query: 644 SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIAL 703
SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIAL
Sbjct: 551 SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIAL 610
Query: 704 MDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLY 763
MDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLY
Sbjct: 611 MDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLY 670
Query: 764 DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 671 DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728
>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
Length = 690
Score = 776 bits (2003), Expect = 0.0
Identities = 387/804 (48%), Positives = 517/804 (64%), Gaps = 123/804 (15%)
Query: 18 RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75
R+PGP HP A T + G ++FEQ+ ++CL++ L+
Sbjct: 6 RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43
Query: 76 VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135
D +FP +SLFYS++ I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 44 EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103
Query: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195
A LTLNQ L RVIP DQSF YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF S
Sbjct: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163
Query: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255
NEFWSALLEKAYAKL+GSYEALKGG+ EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223
Query: 256 IERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTR 315
++RGSL+GC ID
Sbjct: 224 LKRGSLLGCFID------------------------------------------------ 235
Query: 316 TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKD 375
T + E R GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQVEWNGSWSD +
Sbjct: 236 TRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPE 295
Query: 376 WSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNE 435
W V E+ RL H +DGEFWM+++DF HF K+EICNLT DAL+ D + W V+V++
Sbjct: 296 WRSVGPAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ 355
Query: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495
G WVRG +AGGCRNF DTFWTNPQ +L L E+D+ ++ CSFLVALMQK+RRK ++
Sbjct: 356 GSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRF 411
Query: 496 GASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYV 555
GA++ TIG+AIYE P + +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+
Sbjct: 412 GANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 467
Query: 556 IVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKEL 615
++PST+EPHQE +F LR+FSEK+ ++ +++ + +D P K T P
Sbjct: 468 LIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPP-------------- 513
Query: 616 GVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKK 675
DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+
Sbjct: 514 -----------------------------DQETEEEQRFRALFEQVAGEDMEVTAEELEY 544
Query: 676 VLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYD 735
VLN V+ K KD+K +L SC+++I+LMDT G+GKL EF W+K+K W +F +D
Sbjct: 545 VLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFD 604
Query: 736 TDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRA 795
D+SGT+++YE+R A+ AGF L++ L +I +RYAD+ + +DFD F+ C VRLE R
Sbjct: 605 ADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRV 664
Query: 796 FHAFDKDGDGIIKLNVLEWLQLTM 819
F A I LN+ E++ LTM
Sbjct: 665 FQALSTKNKEFIHLNINEFIHLTM 688
>gi|12408656 calpain 1, large subunit [Homo sapiens]
Length = 714
Score = 743 bits (1917), Expect = 0.0
Identities = 376/770 (48%), Positives = 508/770 (65%), Gaps = 106/770 (13%)
Query: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
+EQL +CL+ L+ D FPP SL Y P WKRP E+ NP+FI+DG
Sbjct: 42 YEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDG 101
Query: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
A RTDICQG LGDCW LAAIA LTLN LL RV+PH QSF YAGIFHFQ W++GEWVD
Sbjct: 102 ATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVD 161
Query: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
VV+DD LP + +LVF S NEFWSALLEKAYAK++GSYEAL GG+T+E EDFTGGV
Sbjct: 162 VVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGV 221
Query: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295
E++E+R APSD+Y+I+ KA+ERGSL+GC ++D
Sbjct: 222 TEWYELRKAPSDLYQIILKALERGSLLGC----------------------------SID 253
Query: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355
S + D + + ++ LV+GHAYSVTG +V ++G+ V L+R
Sbjct: 254 ISSVLDMEA---------------ITFKK-----LVKGHAYSVTGAKQVNYRGQVVSLIR 293
Query: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415
+RNPWG+VEW G+WSD +W+ VD E+ +L+ ++ EDGEFWMS+ DF+ FT+LEICN
Sbjct: 294 MRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKM-EDGEFWMSFRDFMREFTRLEICN 352
Query: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPD--- 472
LT DAL+S ++ W ++ EG W RG +AGGCRN+P TFW NPQ++++ L+E DDPD
Sbjct: 353 LTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIR-LDETDDPDDYG 411
Query: 473 DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASK 531
D E CSF++ALMQK+RR++R+ G + TIGFA+YEVP E+ G HL++DFFL NAS+
Sbjct: 412 DRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASR 471
Query: 532 ARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVD 591
ARS+ +IN+REVS RFRLPP EYV+VPST+EP++EG+F+LR FSEK + E+++ I +
Sbjct: 472 ARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQAN 531
Query: 592 RPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQ 651
PD+Q S E E
Sbjct: 532 -------------------------------------LPDEQVLS----------EEEID 544
Query: 652 QQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGK 711
+ F+ +F+Q+AG+DMEI EL+ +LN +++KHKDL+T GF+LESCRSM+ LMD DG+GK
Sbjct: 545 ENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGK 604
Query: 712 LNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYA 771
L L EF+ LWN+I+ + IF+ +D D+SG++++YEMR A+ AGF LN +LY++I RY+
Sbjct: 605 LGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYS 664
Query: 772 DKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
+ + +DFD+F+CC VRLE MFR F D D DG++ ++ +WLQLTM+A
Sbjct: 665 EPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714
>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
Length = 664
Score = 741 bits (1913), Expect = 0.0
Identities = 377/804 (46%), Positives = 504/804 (62%), Gaps = 149/804 (18%)
Query: 18 RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75
R+PGP HP A T + G ++FEQ+ ++CL++ L+
Sbjct: 6 RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43
Query: 76 VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135
D +FP +SLFYS++ I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 44 EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103
Query: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195
A LTLNQ L RVIP DQSF YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF S
Sbjct: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163
Query: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255
NEFWSALLEKAYAKL+GSYEALKGG+ EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223
Query: 256 IERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTR 315
++RGSL+GC ID
Sbjct: 224 LKRGSLLGCFID------------------------------------------------ 235
Query: 316 TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKD 375
T + E R GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQVEWNGSWSDR
Sbjct: 236 TRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR--- 292
Query: 376 WSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNE 435
M+++DF HF K+EICNLT DAL+ D + W V+V++
Sbjct: 293 -----------------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ 329
Query: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495
G WVRG +AGGCRNF DTFWTNPQ +L L E+D+ ++ CSFLVALMQK+RRK ++
Sbjct: 330 GSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRF 385
Query: 496 GASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYV 555
GA++ TIG+AIYE P + +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+
Sbjct: 386 GANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 441
Query: 556 IVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKEL 615
++PST+EPHQE +F LR+FSEK+ ++ +++ + +D P K T P
Sbjct: 442 LIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPP-------------- 487
Query: 616 GVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKK 675
DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+
Sbjct: 488 -----------------------------DQETEEEQRFRALFEQVAGEDMEVTAEELEY 518
Query: 676 VLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYD 735
VLN V+ K KD+K +L SC+++I+LMDT G+GKL EF W+K+K W +F +D
Sbjct: 519 VLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFD 578
Query: 736 TDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRA 795
D+SGT+++YE+R A+ AGF L++ L +I +RYAD+ + +DFD F+ C VRLE R
Sbjct: 579 ADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRV 638
Query: 796 FHAFDKDGDGIIKLNVLEWLQLTM 819
F A I LN+ E++ LTM
Sbjct: 639 FQALSTKNKEFIHLNINEFIHLTM 662
>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
Length = 700
Score = 700 bits (1807), Expect = 0.0
Identities = 349/761 (45%), Positives = 487/761 (63%), Gaps = 103/761 (13%)
Query: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
+E L +CLE L+ DP FP ++L + + P WKRP EIC +P+FII G
Sbjct: 32 YEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGG 91
Query: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
A RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIFHFQFW+YGEWV+
Sbjct: 92 ATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVE 151
Query: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
VV+DD LPT + +L+F S +EFWSALLEKAYAK++G YEAL GG TTE EDFTGG+
Sbjct: 152 VVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGI 211
Query: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295
AE++E++ P +++KI++KA+++GSL+GCSI D
Sbjct: 212 AEWYELKKPPPNLFKIIQKALQKGSLLGCSI----------------------------D 243
Query: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355
+ DS+ + ++ LV+GHAYSVTG +EV G KL+R
Sbjct: 244 ITSAADSEA---------------ITFQK-----LVKGHAYSVTGAEEVESNGSLQKLIR 283
Query: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415
+RNPWG+VEW G W+D W+ +D +E+ RL + EDGEFWMS+ DF+ H+++LEICN
Sbjct: 284 IRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSDFLRHYSRLEICN 342
Query: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSE 475
LT D L SD + W ++ +G W RG +AGGCRN+P+TFW NPQY +KL EED+D +D E
Sbjct: 343 LTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGE 402
Query: 476 VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASKARS 534
C+FLV L+QK+RR+ RK+G + TIGF IYEVP+E+ G HL K+FFL N ++ RS
Sbjct: 403 SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERS 462
Query: 535 KTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV 594
T+IN+REV RF+LPP EY++VPST+EP+++G+F +RVFSEK+ + V++ I +
Sbjct: 463 DTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANL-- 520
Query: 595 KKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQF 654
+E + E + F
Sbjct: 521 ------------------EEFDI----------------------------SEDDIDDGF 534
Query: 655 RNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNL 714
R +F Q+AG+D EI A EL+ +L V+ K +D+K+ GF++E+C+ M+ ++D+DGSGKL L
Sbjct: 535 RRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGL 594
Query: 715 QEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKH 774
+EF+ LW KI+ +QKI++ D D+SGT+NSYEMR A+ +AGF + QL+ +I R+AD
Sbjct: 595 KEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQ 654
Query: 775 MNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 815
+ IDFD+F+ C VRLE +F+ F D + G I+L+++ WL
Sbjct: 655 LIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695
>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
Length = 622
Score = 673 bits (1736), Expect = 0.0
Identities = 333/713 (46%), Positives = 464/713 (65%), Gaps = 98/713 (13%)
Query: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163
EIC +P+FII GA RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIF
Sbjct: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
Query: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223
HFQFW+YGEWV+VV+DD LPT + +L+F S +EFWSALLEKAYAK++G YEAL GG
Sbjct: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
Query: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 283
TTE EDFTGG+AE++E++ P +++KI++KA+++GSL+GCSI
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI----------------- 164
Query: 284 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 343
D + DS+ + ++ LV+GHAYSVTG +E
Sbjct: 165 -----------DITSAADSEA---------------ITFQK-----LVKGHAYSVTGAEE 193
Query: 344 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 403
V G KL+R+RNPWG+VEW G W+D W+ +D +E+ RL + EDGEFWMS+ D
Sbjct: 194 VESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSD 252
Query: 404 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463
F+ H+++LEICNLT D L SD + W ++ +G W RG +AGGCRN+P+TFW NPQY +K
Sbjct: 253 FLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIK 312
Query: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQK 522
L EED+D +D E C+FLV L+QK+RR+ RK+G + TIGF IYEVP+E+ G HL K
Sbjct: 313 LEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSK 372
Query: 523 DFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSE 582
+FFL N ++ RS T+IN+REV RF+LPP EY++VPST+EP+++G+F +RVFSEK+ +
Sbjct: 373 NFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQ 432
Query: 583 EVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPG 642
V++ I + +E +
Sbjct: 433 AVDDEIEANL--------------------EEFDI------------------------- 447
Query: 643 SSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIA 702
E + FR +F Q+AG+D EI A EL+ +L V+ K +D+K+ GF++E+C+ M+
Sbjct: 448 ---SEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVD 504
Query: 703 LMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQL 762
++D+DGSGKL L+EF+ LW KI+ +QKI++ D D+SGT+NSYEMR A+ +AGF + QL
Sbjct: 505 MLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQL 564
Query: 763 YDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 815
+ +I R+AD + IDFD+F+ C VRLE +F+ F D + G I+L+++ WL
Sbjct: 565 HQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 617
>gi|215490104 calpain 11 [Homo sapiens]
Length = 739
Score = 671 bits (1732), Expect = 0.0
Identities = 357/771 (46%), Positives = 474/771 (61%), Gaps = 105/771 (13%)
Query: 59 KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFP----IQFV-WKRPPEICENPRFII 113
++FE+L CL K L+ DP FP + +SL + P +Q + W+RP +I NP FI+
Sbjct: 64 QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123
Query: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173
DG + TDICQG LGDCW LAAI LT LL+RV+P QSF +NYAGIFHFQ W++G+W
Sbjct: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183
Query: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
V+VV+DD LPT N++LVF S R+EFWSALLEKAYAKL GSYEAL GG+T E +EDFTG
Sbjct: 184 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTG 243
Query: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293
GVA+ F+++ P ++ ++++KA+ER SLMGCSI+
Sbjct: 244 GVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIE-------------------------- 277
Query: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353
+ DS+L+ +D+ LVRGHAYSVTGL +V ++G+ L
Sbjct: 278 ----VTSDSELESM-TDKM-----------------LVRGHAYSVTGLQDVHYRGKMETL 315
Query: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413
+R+RNPWG++EWNG+WSD ++W V D + +L H+ TEDGEFWMSY+DF+ +FT LEI
Sbjct: 316 IRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHK-TEDGEFWMSYQDFLNNFTLLEI 374
Query: 414 CNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDD 473
CNLT D L D W + EG W RG SAGGCRN P TFWTNPQ+++ L E DD DD
Sbjct: 375 CNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDD 434
Query: 474 SE---VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNA 529
+E V+C+ LVALMQKN R R+ GA L TIGF +Y VPKE + HL+K+FF
Sbjct: 435 AEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQ 494
Query: 530 SKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTIS 589
S+ + N REVS + RLPP EY+I+PST+EPH++ +F+LRVF+EK + S E+
Sbjct: 495 DHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWEL----- 549
Query: 590 VDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE 649
D N ++L ++ SE+ +
Sbjct: 550 -----------------DEVNYAEQLQEEKVSED-------------------------D 567
Query: 650 EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS 709
Q F ++FK +AG+ EI EL+++LN + K K KT GF L++CR MI LMD DGS
Sbjct: 568 MDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGS 627
Query: 710 GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR 769
GKL L EF LW K+K W IF+ D D SGT+NSYEMR + AG LNN++ ++ R
Sbjct: 628 GKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVAR 687
Query: 770 YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 820
YAD + IDFDSFI CF+RL+ MF F D G I L++ +WLQ+TM+
Sbjct: 688 YADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
>gi|221554549 calpain 8 [Homo sapiens]
Length = 703
Score = 646 bits (1667), Expect = 0.0
Identities = 333/763 (43%), Positives = 463/763 (60%), Gaps = 104/763 (13%)
Query: 61 FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
F+ L ++CL+ VL+ DPEFP ++L Y P +WKRP E+C +P+FI+ G
Sbjct: 32 FKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIVGG 91
Query: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
A RTDICQG LGDCW LAAIA LTLN+ LL+RV+P DQ F ENYAGIFHFQFW+YGEWV+
Sbjct: 92 ATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEWVE 151
Query: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
VVIDD LPT N QL+F S NEFWSALLEKAYAKL+G YEAL GG+T E EDFTGG+
Sbjct: 152 VVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGI 211
Query: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295
S+ Y + K ++ ++ G+ + S E I
Sbjct: 212 ----------SEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQK---- 257
Query: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355
LV+ HAYSVTG++EV F+G KL+R
Sbjct: 258 ----------------------------------LVKSHAYSVTGVEEVNFQGHPEKLIR 283
Query: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415
LRNPWG+VEW+G+WSD +W+ +D K L +V EDGEFWMS DF+ F++LEICN
Sbjct: 284 LRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKV-EDGEFWMSLSDFVRQFSRLEICN 342
Query: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDS- 474
L+ D+L S+++ W + + G W RG +AGGC+N+P T+WTNPQ++++L E D+D ++S
Sbjct: 343 LSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESI 402
Query: 475 -EVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASKA 532
E C+ L+ LMQKNRR +++G + +IG+A+Y+VPKE+ + HL +DFFL A
Sbjct: 403 GEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSA 462
Query: 533 RSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDR 592
R+ TY+N+REVS R RLPP EY++VPST+EP ++GEF LRVFSEK+ + E+ + ++
Sbjct: 463 RTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVA--- 519
Query: 593 PVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQ 652
+P P DQE +
Sbjct: 520 -----------------------------------------GNPYEPHPSEVDQEDD--- 535
Query: 653 QFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKL 712
QFR +F+++AG D EI A+ LK +LN +K D+K GF + +CR MI+L+D++G+G L
Sbjct: 536 QFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTL 595
Query: 713 NLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYAD 772
EF LW KI+ + +I+ D + SGTI+++EMR A+ AGF LN+Q+ I +RYA
Sbjct: 596 GAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYAC 655
Query: 773 KHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 815
+ I+FDSF+ C +RLE +F+ F D+D DG+++L++ EWL
Sbjct: 656 SKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698
>gi|27765076 calpain 3 isoform d [Homo sapiens]
Length = 309
Score = 634 bits (1634), Expect = 0.0
Identities = 309/309 (100%), Positives = 309/309 (100%)
Query: 513 MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 572
MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR
Sbjct: 1 MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 60
Query: 573 VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 632
VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK
Sbjct: 61 VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 120
Query: 633 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 692
QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF
Sbjct: 121 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 180
Query: 693 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 752
TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN
Sbjct: 181 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 240
Query: 753 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 812
DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL
Sbjct: 241 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 300
Query: 813 EWLQLTMYA 821
EWLQLTMYA
Sbjct: 301 EWLQLTMYA 309
>gi|38707981 calpain 12 [Homo sapiens]
Length = 719
Score = 480 bits (1236), Expect = e-135
Identities = 279/793 (35%), Positives = 408/793 (51%), Gaps = 133/793 (16%)
Query: 59 KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFII 113
+++E + CL+ +L+ DP FP +L Y Q P W RP E C P+FI
Sbjct: 30 QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFIC 89
Query: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173
+ +RTD+CQG LG+CWFLAA A LTL LL RV+P Q F YAG+FHFQ W++G W
Sbjct: 90 EDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFGRW 149
Query: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
+DVV+DD LP +L+F +S RNEFW+ LLEKAYAKLHGSYE ++GG+ EA DFTG
Sbjct: 150 MDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTG 209
Query: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293
GV E +R ++ ++ A+ + SL+G +
Sbjct: 210 GVGEVLYLRQNSMGLFSALRHALAKESLVGATA--------------------------- 242
Query: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353
L RG E R GLV+GHAYS+TG +V KV+L
Sbjct: 243 ----------LSDRG--------------EYRTEEGLVKGHAYSITGTHKVFLGFTKVRL 278
Query: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413
+RLRNPWG VEW G+WSD W + + + L + EDGEFWM DF+ HF ++I
Sbjct: 279 LRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVK-KEDGEFWMELRDFLLHFDTVQI 337
Query: 414 CNLTADAL-QSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPD 472
C+L+ + L S + W V +GRWVRG ++GG + +TFWTNPQ+RL LLE D++ D
Sbjct: 338 CSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDD 397
Query: 473 DSE---------------------VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPK 511
+ E C+ L++L+Q+NRR+ R G + T+GF ++++P+
Sbjct: 398 EDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPE 457
Query: 512 EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFIL 571
E+ G + L +A R+V++R L P Y++VPST E +F L
Sbjct: 458 ELLGLWDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTL 517
Query: 572 RVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPD 631
RVFSE+R+ + E+++ IS D + P+ ELG++Q
Sbjct: 518 RVFSERRHTAVEIDDVISADLQSLQGPYLPL-----------ELGLEQ------------ 554
Query: 632 KQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHG 691
+F+++AG++ E+ A +L+ +L+ + + + H
Sbjct: 555 -------------------------LFQELAGEEEELNASQLQALLSIAL---EPARAHT 586
Query: 692 FTLE--SCRSMIALMDTDGSGK-LNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMR 748
T R+ L+ G G+ L L F LW + WQ IF +D D SGT+NSYE+R
Sbjct: 587 STPREIGLRTCEQLLQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELR 646
Query: 749 NAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIK 808
A+N AGFHLNNQL +T RY D + +DF+ F+ C L +F G+G+I
Sbjct: 647 LALNAAGFHLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVIC 706
Query: 809 LNVLEWLQLTMYA 821
L +W+++ ++
Sbjct: 707 LTHRQWMEVATFS 719
>gi|223468608 calpain 14 [Homo sapiens]
Length = 684
Score = 444 bits (1141), Expect = e-124
Identities = 272/769 (35%), Positives = 388/769 (50%), Gaps = 116/769 (15%)
Query: 58 EKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYS---QKFPIQFVWKRPPEICENPRFIID 114
++ FE L +CL L+ D FP +S+ QK P + WKRPPE+ NP+F
Sbjct: 27 QQDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFA 86
Query: 115 GANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWV 174
A R D+CQG +GDCWFLAA+ L L+Q +L RV+P +QSF E YAGIF F FW YG WV
Sbjct: 87 KAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWV 146
Query: 175 DVVIDDCLPTYN-NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
VVIDD LP QLVF S ++N FW ALLEKAYAKL GSYE L+ G +EA+ DFTG
Sbjct: 147 PVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTG 206
Query: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293
GV + +A +++ I+ +A +L+GC G +
Sbjct: 207 GVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSGEKI--------------------- 245
Query: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353
++N L V GHAY++TG+ +V K L
Sbjct: 246 LENGL--------------------------------VEGHAYTLTGIRKVTCKHRPEYL 273
Query: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413
V+LRNPWG+VEW G WSD W + EK L + DGEFWM+ +DF HF L I
Sbjct: 274 VKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRK-DNDGEFWMTLQDFKTHFVLLVI 332
Query: 414 CNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRN-FPDTFWTNPQYRLKLLEEDDDPD 472
C LT L + Q WT ++ EGRW + +AGG R DTFW NPQ+ L + ++
Sbjct: 333 CKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEGRR 392
Query: 473 DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKA 532
CS LV+L+QK R + RK L IGF +Y + K H +++ L +FF N +
Sbjct: 393 SLRP-CSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNK-YHDDQRRLPPEFFQRNTPLS 449
Query: 533 RSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDR 592
+ ++ +EVSQ L P Y+IVP E HQ+ EF+LRVFS K E N+
Sbjct: 450 QPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHIFYEIGSNS----- 504
Query: 593 PVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQ 652
++F +KE+ DQ + +
Sbjct: 505 --------GVVF-------SKEI----------------------------EDQNERQDE 521
Query: 653 QFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKL 712
F F++ EI A +L+ +LN + + F+LE+C+ ++AL+D + SG +
Sbjct: 522 FFTKFFEK----HPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTM 577
Query: 713 NLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYAD 772
++QEF LW ++K QK+F H SG +N ++ A+ +AG L++ + ++ +RY
Sbjct: 578 SIQEFRDLWKQLKLSQKVF-HKQDRGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGG 636
Query: 773 KHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
+ +DF SFI +R+E M F +DG GI L EW+ + +Y+
Sbjct: 637 PRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKGIY-LQKPEWMMMALYS 684
>gi|37577157 calpain 5 [Homo sapiens]
Length = 640
Score = 361 bits (927), Expect = 1e-99
Identities = 210/548 (38%), Positives = 287/548 (52%), Gaps = 94/548 (17%)
Query: 57 KEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGA 116
+++ + L + C +KVL+ DP FP + SL+Y WKRP ICE+PR +DG
Sbjct: 9 EDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGI 68
Query: 117 NRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHFQFWRY 170
+ D+ QG++G+CWF+AA + L + L +VIP D YAGIFHF FWR+
Sbjct: 69 SSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRF 128
Query: 171 GEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMED 230
GEWVDVVIDD LPT NNQL++ SN RNEFW AL+EKAYAKL G Y+AL GGNT +A+ D
Sbjct: 129 GEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVD 188
Query: 231 FTGGVAEFFEIRDAP--------SDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLN 282
FTGGV+E ++ + + +++ M K RG L+ SI
Sbjct: 189 FTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASI---------------- 232
Query: 283 MGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLD 342
+ + E R+ACGLV+GHAY+VT +
Sbjct: 233 --------------------------------KAVTAADMEARLACGLVKGHAYAVTDVR 260
Query: 343 EVP--------FKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED 394
+V FK EK+ ++RLRNPWG+ EWNG WSD ++W V K E+ ++ V +D
Sbjct: 261 KVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDD 320
Query: 395 GEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWV-----RGCSAGGCRN 449
GEFWM++ED +FT + C + + S +TW + G W R GGC N
Sbjct: 321 GEFWMTFEDVCRYFTDIIKCRVINTSHLSIH-KTWEEARLHGAWTLHEDPRQNRGGGCIN 379
Query: 450 FPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG-ASLFTIGFAIYE 508
DTF+ NPQY + E P+D +IC + Q+ +R R+ G IGF IY+
Sbjct: 380 HKDTFFQNPQY----IFEVKKPEDEVLIC-----IQQRPKRSTRREGKGENLAIGFDIYK 430
Query: 509 VPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGE 568
V + LQ KA S YIN R V R P YVI+P+T+EP GE
Sbjct: 431 VEENRQYRMHSLQ--------HKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGE 482
Query: 569 FILRVFSE 576
F+LRVF++
Sbjct: 483 FLLRVFTD 490
>gi|27765080 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 329 bits (844), Expect = 6e-90
Identities = 156/156 (100%), Positives = 156/156 (100%)
Query: 666 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 725
MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK
Sbjct: 1 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60
Query: 726 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 785
AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC
Sbjct: 61 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120
Query: 786 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156
>gi|27765078 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 329 bits (844), Expect = 6e-90
Identities = 156/156 (100%), Positives = 156/156 (100%)
Query: 666 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 725
MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK
Sbjct: 1 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60
Query: 726 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 785
AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC
Sbjct: 61 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120
Query: 786 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156
>gi|41152101 calpain 13 [Homo sapiens]
Length = 669
Score = 300 bits (769), Expect = 3e-81
Identities = 223/783 (28%), Positives = 354/783 (45%), Gaps = 142/783 (18%)
Query: 53 IIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSL---FYSQKFPIQFVWKRPPEICENP 109
II K++ F L CL + D FP ++S+ +K +WKRP ++ P
Sbjct: 13 IIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGP 72
Query: 110 -RFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFW 168
FI+D +R DI QG DCWFLAA+ LT N +++ QSF YAGIF F+FW
Sbjct: 73 PHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFW 131
Query: 169 RYGEWVDVVIDDCLPTYNNQLVFTKSNHRN-EFWSALLEKAYAKLHGSYEALKGGNTTEA 227
+ G+WV+VVIDD LP ++ +F + H+N EFW LLEKAYAKL GSY L G +A
Sbjct: 132 QCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDA 191
Query: 228 MEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELI 287
+ D TGGV + +P D+ K +K A + GSL+ C+ +PSG
Sbjct: 192 LVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCA-----------TPSG------- 233
Query: 288 ARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK 347
P M GLV HAY+VTG +++ ++
Sbjct: 234 -------------------------------PTDTAQAMENGLVSLHAYTVTGAEQIQYR 262
Query: 348 GEKVKLVRLRNP--WGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFI 405
+++ L NP WG+ EW G WSD ++W K++L H+ EDGEFWMS +DF
Sbjct: 263 RGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQL-HKKREDGEFWMSCQDFQ 321
Query: 406 YHFTKLEICNLTADALQSDKL--QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463
F + IC+ L + W+ + + + G +AGG RN + Q+
Sbjct: 322 QKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-------DAQFNFS 374
Query: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 523
+ E + + V+C + + +D K F + F + + ++
Sbjct: 375 VQEPME--GTNVVVCVTVAVTPSNLKAEDAK-----FPLDFQVILAGSQRF--REKFPPV 425
Query: 524 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 583
FF + +S R + + L P YV+V T + EF+LR+F + +
Sbjct: 426 FFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLLRIFLKMPDSDRH 483
Query: 584 VENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS 643
+ + ++ + K SP
Sbjct: 484 LSSHFNL-----------------------------------------RMKGSP------ 496
Query: 644 SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLN--TVVNKHKDLKTHGFTLESCRSMI 701
SE Q ++IF + A ++I A +L+ +LN + D+ F+L+ CRS++
Sbjct: 497 ----SEHGSQ-QSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDM----FSLDECRSLV 547
Query: 702 ALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDA----GFH 757
ALM+ +G+L+ +EF LW ++ +Q +F+ T G + S ++ A+ + G
Sbjct: 548 ALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQT-SPGVLLSSDLWKAIENTDFLRGIF 606
Query: 758 LNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQL 817
++ +L ++T+RY+D + F S +C +RLE M + F KDG G+ L +EW+ L
Sbjct: 607 ISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLY-LTEMEWMSL 665
Query: 818 TMY 820
MY
Sbjct: 666 VMY 668
>gi|13186316 calpain 6 [Homo sapiens]
Length = 641
Score = 293 bits (749), Expect = 6e-79
Identities = 185/553 (33%), Positives = 281/553 (50%), Gaps = 95/553 (17%)
Query: 52 PIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRF 111
P+ K + +++L ++C++ L+ DP F P+ SLFY++ P + VWKRP +IC++P
Sbjct: 4 PLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHL 63
Query: 112 IIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHF 165
I+ + + QG LG ++A +CL + + + IP+ D E YAGIFHF
Sbjct: 64 IVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHF 123
Query: 166 QFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTT 225
+FW +GEW +VVIDD LPT N LVF+ S NEFW+ALLEKAYAKL G YEAL G T
Sbjct: 124 RFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTIT 183
Query: 226 EAMEDFTGGVAEFFEIR-----DAPSDMYKI---MKKAIERGSLMGCSIDDGTNMTYGTS 277
+ + DFTG +AE +++ + + YK+ + K +G L+ CSI+ S
Sbjct: 184 DIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIE---------S 234
Query: 278 PSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYS 337
P+ + E GL++GH Y+
Sbjct: 235 PN---------------------------------------QEEQEVETDWGLLKGHTYT 255
Query: 338 VTGLDEV--------PFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQH 389
+T + ++ F EKV +VRLRNP G+ EW+G WS+ ++W + ++ L
Sbjct: 256 MTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGL 315
Query: 390 QVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDK-----LQTWTVSVNEGRWVRGCSA 444
+++DGEFWMS EDF +F KL +C + + K L WTV ++ R +
Sbjct: 316 VMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVD-DDPLMNR---S 371
Query: 445 GGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG-ASLFTIG 503
GGC N DTF NPQY + P+D + +++L QK+ R R++G + IG
Sbjct: 372 GGCYNNRDTFLQNPQYIFTV------PEDGHKV---IMSLQQKDLRTYRRMGRPDNYIIG 422
Query: 504 FAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEP 563
F +++V H LY +A + TYI+ R V L YV+VP+ ++
Sbjct: 423 FELFKVEMNRKFRLHH------LYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQH 476
Query: 564 HQEGEFILRVFSE 576
+ EF+LR+FSE
Sbjct: 477 GRTSEFLLRIFSE 489
>gi|4502565 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 224 bits (572), Expect = 2e-58
Identities = 106/192 (55%), Positives = 140/192 (72%), Gaps = 6/192 (3%)
Query: 636 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 689
+P+P P + ESEE +QFR +F Q+AGDDME+ A EL +LN VV +H DLKT
Sbjct: 77 NPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKT 136
Query: 690 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 749
GF +++CRSM+A+MD+D +GKL +EF +LWN IK WQ I+K +DTD+SGTI S E+
Sbjct: 137 DGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPG 196
Query: 750 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 809
A AGFHLN LY++I RY+D+ N+DFD+FI C VRL+ MFRAF + DKDG G I++
Sbjct: 197 AFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQV 256
Query: 810 NVLEWLQLTMYA 821
N+ EWLQLTMY+
Sbjct: 257 NIQEWLQLTMYS 268
>gi|51599151 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 224 bits (572), Expect = 2e-58
Identities = 106/192 (55%), Positives = 140/192 (72%), Gaps = 6/192 (3%)
Query: 636 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 689
+P+P P + ESEE +QFR +F Q+AGDDME+ A EL +LN VV +H DLKT
Sbjct: 77 NPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKT 136
Query: 690 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 749
GF +++CRSM+A+MD+D +GKL +EF +LWN IK WQ I+K +DTD+SGTI S E+
Sbjct: 137 DGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPG 196
Query: 750 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 809
A AGFHLN LY++I RY+D+ N+DFD+FI C VRL+ MFRAF + DKDG G I++
Sbjct: 197 AFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQV 256
Query: 810 NVLEWLQLTMYA 821
N+ EWLQLTMY+
Sbjct: 257 NIQEWLQLTMYS 268
>gi|13186302 calpain 10 isoform a [Homo sapiens]
Length = 672
Score = 215 bits (548), Expect = 1e-55
Identities = 166/533 (31%), Positives = 242/533 (45%), Gaps = 83/533 (15%)
Query: 74 LYVDPEFPPDETSLFYSQKFPI-----QFVWKRPPEICENPRFIIDGANRTDICQGELGD 128
L+ D FP ++SLF P+ W+RP EIC PR D + QG LGD
Sbjct: 13 LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
Query: 129 CWFLAAIACLTLNQHLLFRVIPHDQSFI--ENYAGIFHFQFWRYGEWVDVVIDDCLPTYN 186
CWFL A A L ++HLL +VIP Q + Y G F + W++G WV+V DD LP
Sbjct: 73 CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
Query: 187 NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPS 246
+L F++ + FW LLEK YAK+HGSYE L G +A+ D TGG+A
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLA---------- 182
Query: 247 DMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDP 306
ER +L G + G G +++ D L+ L P
Sbjct: 183 ----------ERWNLKGVAGSGGQQ-----DRPGRWEHRTCRQLLHLKDQCLISCCVLSP 227
Query: 307 RGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK-GEKVKLVRLRNPWGQVEW 365
R A L HA+ V+ L E+ + G+ + L+R++NPWG+ W
Sbjct: 228 RAG-----------------ARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCW 270
Query: 366 NGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA----- 420
G W + + WS VD + L Q+ ++GEFW+ E+F+ F +L + +A
Sbjct: 271 QGLWREGGEGWSQVDAAVASELLSQL-QEGEFWVEEEEFLREFDELTVGYPVTEAGHLQS 329
Query: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
L +++L T ++ G WV+G SAGGCRN F +NP++ L++ E SEV
Sbjct: 330 LYTERLLCHTRAL-PGAWVKGQSAGGCRN-NSGFPSNPKFWLRVSE------PSEV---- 377
Query: 481 LVALMQKNRRKDRK-LGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKAR------ 533
+A++Q++R G + +G + K + L+ K R
Sbjct: 378 YIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRV 437
Query: 534 --------SKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 578
+ + REV R L P Y+ VPST+ GEF+LRVFS R
Sbjct: 438 LSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGR 490
Score = 44.3 bits (103), Expect = 5e-04
Identities = 43/145 (29%), Positives = 60/145 (41%), Gaps = 16/145 (11%)
Query: 429 WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKN 488
W G W G +AGG RNF ++ TNP + + P+ C + L Q
Sbjct: 514 WGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV------PEGPGPRC-VRITLHQHC 565
Query: 489 RRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFR 548
R D + IGF I++VP+ G Q L + +EVS+
Sbjct: 566 RPSDTEF----HPIGFHIFQVPEG--GRSQDAPP--LLLQEPLLSCVPHRYAQEVSRLCL 617
Query: 549 LPPSEYVIVPSTYEPHQEGEFILRV 573
LP Y +VPSTY P EG F + +
Sbjct: 618 LPAGTYKVVPSTYLPDTEGAFTVTI 642
>gi|14161692 calpain small subunit 2 [Homo sapiens]
Length = 248
Score = 210 bits (534), Expect = 5e-54
Identities = 96/192 (50%), Positives = 140/192 (72%), Gaps = 6/192 (3%)
Query: 636 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 689
+P+P P ESEE ++FR F Q+AG DME+ A +L +LN V++KHKDLKT
Sbjct: 57 TPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKT 116
Query: 690 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 749
GF+L++CRS++++MD+D +GKL +EF +LWN IK WQ ++K YD D SG++ S ++R
Sbjct: 117 DGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRG 176
Query: 750 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 809
A+ AGF LN QLY +I RYA++ ++DF++FI C VRL+ MFRAF + D+D DG+I++
Sbjct: 177 ALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQV 236
Query: 810 NVLEWLQLTMYA 821
++ EWLQLTMY+
Sbjct: 237 SIKEWLQLTMYS 248
>gi|89353291 calpain 10 isoform c [Homo sapiens]
Length = 517
Score = 209 bits (531), Expect = 1e-53
Identities = 164/534 (30%), Positives = 242/534 (45%), Gaps = 93/534 (17%)
Query: 74 LYVDPEFPPDETSLFYSQKFPI-----QFVWKRPPEICENPRFIIDGANRTDICQGELGD 128
L+ D FP ++SLF P+ W+RP EIC PR D + QG LGD
Sbjct: 13 LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
Query: 129 CWFLAAIACLTLNQHLLFRVIPHDQSFI--ENYAGIFHFQFWRYGEWVDVVIDDCLPTYN 186
CWFL A A L ++HLL +VIP Q + Y G F + W++G WV+V DD LP
Sbjct: 73 CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
Query: 187 NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPS 246
+L F++ + FW LLEK YAK+HGSYE L G +A+ D TGG+A
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLA---------- 182
Query: 247 DMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDP 306
ER +L G + G G +++ D L+ L P
Sbjct: 183 ----------ERWNLKGVAGSGGQQ-----DRPGRWEHRTCRQLLHLKDQCLISCCVLSP 227
Query: 307 RGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK-GEKVKLVRLRNPWGQVEW 365
R A L HA+ V+ L E+ + G+ + L+R++NPWG+ W
Sbjct: 228 RAG-----------------ARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCW 270
Query: 366 NGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA----- 420
G W + + WS VD + L Q+ ++GEFW+ E+F+ F +L + +A
Sbjct: 271 QGLWREGGEGWSQVDAAVASELLSQL-QEGEFWVEEEEFLREFDELTVGYPVTEAGHLQS 329
Query: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
L +++L T ++ G WV+G SAGGCRN F +NP++ L++ E SEV
Sbjct: 330 LYTERLLCHTRAL-PGAWVKGQSAGGCRN-NSGFPSNPKFWLRVSE------PSEV---- 377
Query: 481 LVALMQKNR-------RKDRKL--------------GASLFTIGFAIYEVPKEMHGNKQH 519
+A++Q++R + R L G +G +++VP+ G Q
Sbjct: 378 YIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVPE--GGRSQD 435
Query: 520 LQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRV 573
L + +EVS+ LP Y +VPSTY P EG F + +
Sbjct: 436 APP--LLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTI 487
>gi|5032105 small optic lobes [Homo sapiens]
Length = 1086
Score = 157 bits (398), Expect = 3e-38
Identities = 118/385 (30%), Positives = 164/385 (42%), Gaps = 77/385 (20%)
Query: 55 GVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQF---VWKRPPEI-CENPR 110
G + +E + C E V +VD FPP S+ + +Q W RP EI C R
Sbjct: 468 GEAKALWENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFR 527
Query: 111 ------FIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFH 164
+ +DI QG LG+CWFL+A+A L L+ RV+ E G +
Sbjct: 528 DHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQ 584
Query: 165 FQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNT 224
+ + G W V++DD LP + R + W AL+EKA AKLHGSY AL+ G
Sbjct: 585 VRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRA 644
Query: 225 TEAMEDFTGGVAEFFEI-------RDAPSDMYKIMKKAI---ERGSLMGCSIDDGTNMTY 274
E + TG E + R+ P D I K + E G LMG S G NM
Sbjct: 645 IEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGG-NM-- 701
Query: 275 GTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGH 334
+D+S + L PR H
Sbjct: 702 ------------------KVDDSAYESLGLRPR--------------------------H 717
Query: 335 AYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED 394
AYS+ + +V + +L+RLRNPWG+ WNGSWSD W W + L + +
Sbjct: 718 AYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PGHLRGELMPHGSSE 770
Query: 395 GEFWMSYEDFIYHFTKLEICNLTAD 419
G FWM Y DF+ +F ++IC + +D
Sbjct: 771 GVFWMEYGDFVRYFDSVDICKVHSD 795
>gi|38679884 sorcin isoform b [Homo sapiens]
Length = 183
Score = 102 bits (255), Expect = 1e-21
Identities = 57/181 (31%), Positives = 93/181 (51%), Gaps = 8/181 (4%)
Query: 641 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCR 698
PG + Q F +AG D +I ADEL++ L + +K F LE+CR
Sbjct: 7 PGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCR 61
Query: 699 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 758
M++++D D SG + EF LW + W++ F +DTD+SGT++ E++ A+ GF L
Sbjct: 62 LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRL 121
Query: 759 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 818
+ Q + I RY+ + I FD +I C V+L + +F D G++ +++Q
Sbjct: 122 SPQAVNSIAKRYS-TNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCV 180
Query: 819 M 819
M
Sbjct: 181 M 181
>gi|4507207 sorcin isoform a [Homo sapiens]
Length = 198
Score = 102 bits (255), Expect = 1e-21
Identities = 57/181 (31%), Positives = 93/181 (51%), Gaps = 8/181 (4%)
Query: 641 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCR 698
PG + Q F +AG D +I ADEL++ L + +K F LE+CR
Sbjct: 22 PGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCR 76
Query: 699 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 758
M++++D D SG + EF LW + W++ F +DTD+SGT++ E++ A+ GF L
Sbjct: 77 LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRL 136
Query: 759 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 818
+ Q + I RY+ + I FD +I C V+L + +F D G++ +++Q
Sbjct: 137 SPQAVNSIAKRYS-TNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCV 195
Query: 819 M 819
M
Sbjct: 196 M 196
>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
sapiens]
Length = 217
Score = 96.7 bits (239), Expect = 8e-20
Identities = 59/179 (32%), Positives = 88/179 (49%), Gaps = 4/179 (2%)
Query: 641 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSM 700
P SD S F +AG D E+ A+EL++ L + F+LE+CR M
Sbjct: 41 PAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLT---QSGINGTYSPFSLETCRIM 97
Query: 701 IALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNN 760
IA++D D +GK+ F LW + AW++ F D D SGT+ +E+R A+ G+ L+
Sbjct: 98 IAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSP 157
Query: 761 QLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 819
Q I RY+ K+ I FD ++ C V+L + F D G ++LQ TM
Sbjct: 158 QTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
>gi|7019485 programmed cell death 6 [Homo sapiens]
Length = 191
Score = 80.9 bits (198), Expect = 4e-15
Identities = 51/187 (27%), Positives = 94/187 (50%), Gaps = 10/187 (5%)
Query: 634 KQSPQPQPGSSDQESEEQQQFR-NIFKQIAGDDMEICAD-ELKKVLNTVVNKHKDLKTHG 691
+ P PG + + Q F N+F+++ D + +D EL++ L+
Sbjct: 7 RPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGT-------WTP 59
Query: 692 FTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAV 751
F + RS+I++ D + +N EF +W I WQ +F+ YD D SG I+ E++ A+
Sbjct: 60 FNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQAL 119
Query: 752 NDAGFHLNNQLYDIITMRY-ADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLN 810
+ G+ L++Q +DI+ ++ I FD FI + L+ + F +D D DG I+++
Sbjct: 120 SGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVS 179
Query: 811 VLEWLQL 817
++L +
Sbjct: 180 YEQYLSM 186
>gi|7656959 calpain 7 [Homo sapiens]
Length = 813
Score = 77.8 bits (190), Expect = 4e-14
Identities = 81/325 (24%), Positives = 138/325 (42%), Gaps = 69/325 (21%)
Query: 99 WKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLT-----LNQHLLFRVI-PHD 152
W RP ++ NP I + I Q + DC F+A++A N+ L+ +I P +
Sbjct: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319
Query: 153 QSFIENY--AGIFHFQFWRYGEWVDVVIDDCLPT-YNNQLVFTKSNHRNEFWSALLEKAY 209
+ Y G + + G V+IDD LP + +L+ + SN+++E W +L+EKAY
Sbjct: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379
Query: 210 AKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDG 269
K+ G Y+ G N+ + TG + E + SD K D+
Sbjct: 380 MKVMGGYD-FPGSNSNIDLHALTGWIPERIAMH---SDSQTFSK-------------DNS 422
Query: 270 TNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACG 329
M Y G D + + + E+ G
Sbjct: 423 FRMLYQRFHKG--------------DVLITASTGMMTEAEGEK---------------WG 453
Query: 330 LVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDR-WKDWS-----FVDKDE 383
LV HAY+V LD FKG ++ ++L+NPW + W G +S+ K+W+ +++ D
Sbjct: 454 LVPTHAYAV--LDIREFKG--LRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDP 509
Query: 384 KARLQHQVTEDGEFWMSYEDFIYHF 408
+ Q ++G FW+S++D ++
Sbjct: 510 RTA---QKIDNGIFWISWDDLCQYY 531
Score = 36.2 bits (82), Expect = 0.13
Identities = 37/137 (27%), Positives = 53/137 (38%), Gaps = 32/137 (23%)
Query: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495
G+W G SAGGC NF +T NP Y+ + E L+ L
Sbjct: 694 GKW-SGQSAGGCGNFQETHKNNPIYQFHI----------EKTGPLLIELR---------- 732
Query: 496 GASLFTIGFAIYEVPK-EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEY 554
G +++GF + V G L+K Y Y+ + + P +
Sbjct: 733 GPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFC----YLELENI------PSGIF 782
Query: 555 VIVPSTYEPHQEGEFIL 571
I+PST+ P QEG F L
Sbjct: 783 NIIPSTFLPKQEGPFFL 799
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,954,824
Number of Sequences: 37866
Number of extensions: 1642209
Number of successful extensions: 7804
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 104
Number of HSP's that attempted gapping in prelim test: 7401
Number of HSP's gapped (non-prelim): 390
length of query: 821
length of database: 18,247,518
effective HSP length: 111
effective length of query: 710
effective length of database: 14,044,392
effective search space: 9971518320
effective search space used: 9971518320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.