Guide to the Human Genome
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Search of human proteins with 4557405

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557405 calpain 3 isoform a [Homo sapiens]
         (821 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557405 calpain 3 isoform a [Homo sapiens]                        1702   0.0  
gi|27765072 calpain 3 isoform b [Homo sapiens]                       1684   0.0  
gi|27765074 calpain 3 isoform c [Homo sapiens]                       1476   0.0  
gi|47078247 calpain 3 isoform f [Homo sapiens]                       1473   0.0  
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                         776   0.0  
gi|12408656 calpain 1, large subunit [Homo sapiens]                   743   0.0  
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                         741   0.0  
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       700   0.0  
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       673   0.0  
gi|215490104 calpain 11 [Homo sapiens]                                671   0.0  
gi|221554549 calpain 8 [Homo sapiens]                                 646   0.0  
gi|27765076 calpain 3 isoform d [Homo sapiens]                        634   0.0  
gi|38707981 calpain 12 [Homo sapiens]                                 480   e-135
gi|223468608 calpain 14 [Homo sapiens]                                444   e-124
gi|37577157 calpain 5 [Homo sapiens]                                  361   1e-99
gi|27765080 calpain 3 isoform e [Homo sapiens]                        329   6e-90
gi|27765078 calpain 3 isoform e [Homo sapiens]                        329   6e-90
gi|41152101 calpain 13 [Homo sapiens]                                 300   3e-81
gi|13186316 calpain 6 [Homo sapiens]                                  293   6e-79
gi|4502565 calpain, small subunit 1 [Homo sapiens]                    224   2e-58
gi|51599151 calpain, small subunit 1 [Homo sapiens]                   224   2e-58
gi|13186302 calpain 10 isoform a [Homo sapiens]                       215   1e-55
gi|14161692 calpain small subunit 2 [Homo sapiens]                    210   5e-54
gi|89353291 calpain 10 isoform c [Homo sapiens]                       209   1e-53
gi|5032105 small optic lobes [Homo sapiens]                           157   3e-38
gi|38679884 sorcin isoform b [Homo sapiens]                           102   1e-21
gi|4507207 sorcin isoform a [Homo sapiens]                            102   1e-21
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap...    97   8e-20
gi|7019485 programmed cell death 6 [Homo sapiens]                      81   4e-15
gi|7656959 calpain 7 [Homo sapiens]                                    78   4e-14

>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score = 1702 bits (4409), Expect = 0.0
 Identities = 821/821 (100%), Positives = 821/821 (100%)

Query: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
           MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT
Sbjct: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
           FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120

Query: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
           ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD
Sbjct: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180

Query: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
           CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE
Sbjct: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240

Query: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300
           IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ
Sbjct: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300

Query: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360
           DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW
Sbjct: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360

Query: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420
           GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA
Sbjct: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420

Query: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
           LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF
Sbjct: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480

Query: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540
           LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM
Sbjct: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540

Query: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK 600
           REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK
Sbjct: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK 600

Query: 601 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 660
           PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ
Sbjct: 601 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 660

Query: 661 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 720
           IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL
Sbjct: 661 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 720

Query: 721 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 780
           WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD
Sbjct: 721 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 780

Query: 781 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
           SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 781 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score = 1684 bits (4362), Expect = 0.0
 Identities = 815/821 (99%), Positives = 815/821 (99%), Gaps = 6/821 (0%)

Query: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
           MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT
Sbjct: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
           FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120

Query: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
           ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD
Sbjct: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180

Query: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
           CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE
Sbjct: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240

Query: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300
           IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ
Sbjct: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300

Query: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360
           DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW
Sbjct: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360

Query: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420
           GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA
Sbjct: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420

Query: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
           LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF
Sbjct: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480

Query: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540
           LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM
Sbjct: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540

Query: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK 600
           REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV      
Sbjct: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV------ 594

Query: 601 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 660
           PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ
Sbjct: 595 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 654

Query: 661 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 720
           IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL
Sbjct: 655 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 714

Query: 721 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 780
           WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD
Sbjct: 715 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 774

Query: 781 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
           SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 775 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 815


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score = 1476 bits (3821), Expect = 0.0
 Identities = 729/821 (88%), Positives = 729/821 (88%), Gaps = 92/821 (11%)

Query: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
           MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT
Sbjct: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
           FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120

Query: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
           ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD
Sbjct: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180

Query: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
           CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE
Sbjct: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240

Query: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300
           IRDAPSDMYKIMKKAIERGSLMGCSID                                 
Sbjct: 241 IRDAPSDMYKIMKKAIERGSLMGCSID--------------------------------- 267

Query: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360
                          TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW
Sbjct: 268 ---------------TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 312

Query: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420
           GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA
Sbjct: 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 372

Query: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
           LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF
Sbjct: 373 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 432

Query: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540
           LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM
Sbjct: 433 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 492

Query: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK 600
           REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV      
Sbjct: 493 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV------ 546

Query: 601 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 660
                                                 PQPGSSDQESEEQQQFRNIFKQ
Sbjct: 547 --------------------------------------PQPGSSDQESEEQQQFRNIFKQ 568

Query: 661 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 720
           IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL
Sbjct: 569 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 628

Query: 721 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 780
           WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD
Sbjct: 629 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 688

Query: 781 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
           SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 689 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score = 1473 bits (3814), Expect = 0.0
 Identities = 712/718 (99%), Positives = 712/718 (99%), Gaps = 6/718 (0%)

Query: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163
           EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF
Sbjct: 17  EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 76

Query: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223
           HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN
Sbjct: 77  HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 136

Query: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 283
           TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM
Sbjct: 137 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 196

Query: 284 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 343
           GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE
Sbjct: 197 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 256

Query: 344 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 403
           VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED
Sbjct: 257 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 316

Query: 404 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463
           FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK
Sbjct: 317 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 376

Query: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 523
           LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD
Sbjct: 377 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 436

Query: 524 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 583
           FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE
Sbjct: 437 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 496

Query: 584 VENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS 643
           VENTISVDRPV      PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS
Sbjct: 497 VENTISVDRPV------PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS 550

Query: 644 SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIAL 703
           SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIAL
Sbjct: 551 SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIAL 610

Query: 704 MDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLY 763
           MDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLY
Sbjct: 611 MDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLY 670

Query: 764 DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
           DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 671 DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score =  776 bits (2003), Expect = 0.0
 Identities = 387/804 (48%), Positives = 517/804 (64%), Gaps = 123/804 (15%)

Query: 18  RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75
           R+PGP  HP    A  T + G                      ++FEQ+ ++CL++  L+
Sbjct: 6   RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43

Query: 76  VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135
            D +FP   +SLFYS++  I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 44  EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103

Query: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195
           A LTLNQ  L RVIP DQSF   YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S 
Sbjct: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163

Query: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255
             NEFWSALLEKAYAKL+GSYEALKGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223

Query: 256 IERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTR 315
           ++RGSL+GC ID                                                
Sbjct: 224 LKRGSLLGCFID------------------------------------------------ 235

Query: 316 TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKD 375
           T    + E R   GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQVEWNGSWSD   +
Sbjct: 236 TRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPE 295

Query: 376 WSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNE 435
           W  V   E+ RL H   +DGEFWM+++DF  HF K+EICNLT DAL+ D +  W V+V++
Sbjct: 296 WRSVGPAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ 355

Query: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495
           G WVRG +AGGCRNF DTFWTNPQ +L L E+D+  ++    CSFLVALMQK+RRK ++ 
Sbjct: 356 GSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRF 411

Query: 496 GASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYV 555
           GA++ TIG+AIYE P +     +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+
Sbjct: 412 GANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 467

Query: 556 IVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKEL 615
           ++PST+EPHQE +F LR+FSEK+ ++ +++  + +D P   K T P              
Sbjct: 468 LIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPP-------------- 513

Query: 616 GVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKK 675
                                        DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ 
Sbjct: 514 -----------------------------DQETEEEQRFRALFEQVAGEDMEVTAEELEY 544

Query: 676 VLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYD 735
           VLN V+ K KD+K    +L SC+++I+LMDT G+GKL   EF   W+K+K W  +F  +D
Sbjct: 545 VLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFD 604

Query: 736 TDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRA 795
            D+SGT+++YE+R A+  AGF L++ L  +I +RYAD+ + +DFD F+ C VRLE   R 
Sbjct: 605 ADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRV 664

Query: 796 FHAFDKDGDGIIKLNVLEWLQLTM 819
           F A        I LN+ E++ LTM
Sbjct: 665 FQALSTKNKEFIHLNINEFIHLTM 688


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  743 bits (1917), Expect = 0.0
 Identities = 376/770 (48%), Positives = 508/770 (65%), Gaps = 106/770 (13%)

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
           +EQL  +CL+   L+ D  FPP   SL Y    P         WKRP E+  NP+FI+DG
Sbjct: 42  YEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDG 101

Query: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
           A RTDICQG LGDCW LAAIA LTLN  LL RV+PH QSF   YAGIFHFQ W++GEWVD
Sbjct: 102 ATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVD 161

Query: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
           VV+DD LP  + +LVF  S   NEFWSALLEKAYAK++GSYEAL GG+T+E  EDFTGGV
Sbjct: 162 VVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGV 221

Query: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295
            E++E+R APSD+Y+I+ KA+ERGSL+GC                            ++D
Sbjct: 222 TEWYELRKAPSDLYQIILKALERGSLLGC----------------------------SID 253

Query: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355
            S + D +                + ++      LV+GHAYSVTG  +V ++G+ V L+R
Sbjct: 254 ISSVLDMEA---------------ITFKK-----LVKGHAYSVTGAKQVNYRGQVVSLIR 293

Query: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415
           +RNPWG+VEW G+WSD   +W+ VD  E+ +L+ ++ EDGEFWMS+ DF+  FT+LEICN
Sbjct: 294 MRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKM-EDGEFWMSFRDFMREFTRLEICN 352

Query: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPD--- 472
           LT DAL+S  ++ W  ++ EG W RG +AGGCRN+P TFW NPQ++++ L+E DDPD   
Sbjct: 353 LTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIR-LDETDDPDDYG 411

Query: 473 DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASK 531
           D E  CSF++ALMQK+RR++R+ G  + TIGFA+YEVP E+ G    HL++DFFL NAS+
Sbjct: 412 DRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASR 471

Query: 532 ARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVD 591
           ARS+ +IN+REVS RFRLPP EYV+VPST+EP++EG+F+LR FSEK   + E+++ I  +
Sbjct: 472 ARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQAN 531

Query: 592 RPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQ 651
                                                 PD+Q  S          E E  
Sbjct: 532 -------------------------------------LPDEQVLS----------EEEID 544

Query: 652 QQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGK 711
           + F+ +F+Q+AG+DMEI   EL+ +LN +++KHKDL+T GF+LESCRSM+ LMD DG+GK
Sbjct: 545 ENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGK 604

Query: 712 LNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYA 771
           L L EF+ LWN+I+ +  IF+ +D D+SG++++YEMR A+  AGF LN +LY++I  RY+
Sbjct: 605 LGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYS 664

Query: 772 DKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
           +  + +DFD+F+CC VRLE MFR F   D D DG++  ++ +WLQLTM+A
Sbjct: 665 EPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score =  741 bits (1913), Expect = 0.0
 Identities = 377/804 (46%), Positives = 504/804 (62%), Gaps = 149/804 (18%)

Query: 18  RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75
           R+PGP  HP    A  T + G                      ++FEQ+ ++CL++  L+
Sbjct: 6   RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43

Query: 76  VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135
            D +FP   +SLFYS++  I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 44  EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103

Query: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195
           A LTLNQ  L RVIP DQSF   YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S 
Sbjct: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163

Query: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255
             NEFWSALLEKAYAKL+GSYEALKGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223

Query: 256 IERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTR 315
           ++RGSL+GC ID                                                
Sbjct: 224 LKRGSLLGCFID------------------------------------------------ 235

Query: 316 TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKD 375
           T    + E R   GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQVEWNGSWSDR   
Sbjct: 236 TRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR--- 292

Query: 376 WSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNE 435
                                  M+++DF  HF K+EICNLT DAL+ D +  W V+V++
Sbjct: 293 -----------------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ 329

Query: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495
           G WVRG +AGGCRNF DTFWTNPQ +L L E+D+  ++    CSFLVALMQK+RRK ++ 
Sbjct: 330 GSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRF 385

Query: 496 GASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYV 555
           GA++ TIG+AIYE P +     +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+
Sbjct: 386 GANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 441

Query: 556 IVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKEL 615
           ++PST+EPHQE +F LR+FSEK+ ++ +++  + +D P   K T P              
Sbjct: 442 LIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPP-------------- 487

Query: 616 GVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKK 675
                                        DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ 
Sbjct: 488 -----------------------------DQETEEEQRFRALFEQVAGEDMEVTAEELEY 518

Query: 676 VLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYD 735
           VLN V+ K KD+K    +L SC+++I+LMDT G+GKL   EF   W+K+K W  +F  +D
Sbjct: 519 VLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFD 578

Query: 736 TDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRA 795
            D+SGT+++YE+R A+  AGF L++ L  +I +RYAD+ + +DFD F+ C VRLE   R 
Sbjct: 579 ADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRV 638

Query: 796 FHAFDKDGDGIIKLNVLEWLQLTM 819
           F A        I LN+ E++ LTM
Sbjct: 639 FQALSTKNKEFIHLNINEFIHLTM 662


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  700 bits (1807), Expect = 0.0
 Identities = 349/761 (45%), Positives = 487/761 (63%), Gaps = 103/761 (13%)

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
           +E L  +CLE   L+ DP FP   ++L + +  P         WKRP EIC +P+FII G
Sbjct: 32  YEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGG 91

Query: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
           A RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIFHFQFW+YGEWV+
Sbjct: 92  ATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVE 151

Query: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
           VV+DD LPT + +L+F  S   +EFWSALLEKAYAK++G YEAL GG TTE  EDFTGG+
Sbjct: 152 VVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGI 211

Query: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295
           AE++E++  P +++KI++KA+++GSL+GCSI                            D
Sbjct: 212 AEWYELKKPPPNLFKIIQKALQKGSLLGCSI----------------------------D 243

Query: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355
            +   DS+                + ++      LV+GHAYSVTG +EV   G   KL+R
Sbjct: 244 ITSAADSEA---------------ITFQK-----LVKGHAYSVTGAEEVESNGSLQKLIR 283

Query: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415
           +RNPWG+VEW G W+D    W+ +D +E+ RL  +  EDGEFWMS+ DF+ H+++LEICN
Sbjct: 284 IRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSDFLRHYSRLEICN 342

Query: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSE 475
           LT D L SD  + W ++  +G W RG +AGGCRN+P+TFW NPQY +KL EED+D +D E
Sbjct: 343 LTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGE 402

Query: 476 VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASKARS 534
             C+FLV L+QK+RR+ RK+G  + TIGF IYEVP+E+ G    HL K+FFL N ++ RS
Sbjct: 403 SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERS 462

Query: 535 KTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV 594
            T+IN+REV  RF+LPP EY++VPST+EP+++G+F +RVFSEK+   + V++ I  +   
Sbjct: 463 DTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANL-- 520

Query: 595 KKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQF 654
                             +E  +                             E +    F
Sbjct: 521 ------------------EEFDI----------------------------SEDDIDDGF 534

Query: 655 RNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNL 714
           R +F Q+AG+D EI A EL+ +L  V+ K +D+K+ GF++E+C+ M+ ++D+DGSGKL L
Sbjct: 535 RRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGL 594

Query: 715 QEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKH 774
           +EF+ LW KI+ +QKI++  D D+SGT+NSYEMR A+ +AGF +  QL+ +I  R+AD  
Sbjct: 595 KEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQ 654

Query: 775 MNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 815
           + IDFD+F+ C VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 655 LIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  673 bits (1736), Expect = 0.0
 Identities = 333/713 (46%), Positives = 464/713 (65%), Gaps = 98/713 (13%)

Query: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163
           EIC +P+FII GA RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIF
Sbjct: 2   EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61

Query: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223
           HFQFW+YGEWV+VV+DD LPT + +L+F  S   +EFWSALLEKAYAK++G YEAL GG 
Sbjct: 62  HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121

Query: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 283
           TTE  EDFTGG+AE++E++  P +++KI++KA+++GSL+GCSI                 
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI----------------- 164

Query: 284 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 343
                      D +   DS+                + ++      LV+GHAYSVTG +E
Sbjct: 165 -----------DITSAADSEA---------------ITFQK-----LVKGHAYSVTGAEE 193

Query: 344 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 403
           V   G   KL+R+RNPWG+VEW G W+D    W+ +D +E+ RL  +  EDGEFWMS+ D
Sbjct: 194 VESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSD 252

Query: 404 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463
           F+ H+++LEICNLT D L SD  + W ++  +G W RG +AGGCRN+P+TFW NPQY +K
Sbjct: 253 FLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIK 312

Query: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQK 522
           L EED+D +D E  C+FLV L+QK+RR+ RK+G  + TIGF IYEVP+E+ G    HL K
Sbjct: 313 LEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSK 372

Query: 523 DFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSE 582
           +FFL N ++ RS T+IN+REV  RF+LPP EY++VPST+EP+++G+F +RVFSEK+   +
Sbjct: 373 NFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQ 432

Query: 583 EVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPG 642
            V++ I  +                     +E  +                         
Sbjct: 433 AVDDEIEANL--------------------EEFDI------------------------- 447

Query: 643 SSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIA 702
               E +    FR +F Q+AG+D EI A EL+ +L  V+ K +D+K+ GF++E+C+ M+ 
Sbjct: 448 ---SEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVD 504

Query: 703 LMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQL 762
           ++D+DGSGKL L+EF+ LW KI+ +QKI++  D D+SGT+NSYEMR A+ +AGF +  QL
Sbjct: 505 MLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQL 564

Query: 763 YDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 815
           + +I  R+AD  + IDFD+F+ C VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 565 HQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 617


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  671 bits (1732), Expect = 0.0
 Identities = 357/771 (46%), Positives = 474/771 (61%), Gaps = 105/771 (13%)

Query: 59  KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFP----IQFV-WKRPPEICENPRFII 113
           ++FE+L   CL K  L+ DP FP + +SL +    P    +Q + W+RP +I  NP FI+
Sbjct: 64  QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123

Query: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173
           DG + TDICQG LGDCW LAAI  LT    LL+RV+P  QSF +NYAGIFHFQ W++G+W
Sbjct: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183

Query: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
           V+VV+DD LPT N++LVF  S  R+EFWSALLEKAYAKL GSYEAL GG+T E +EDFTG
Sbjct: 184 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTG 243

Query: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293
           GVA+ F+++  P ++ ++++KA+ER SLMGCSI+                          
Sbjct: 244 GVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIE-------------------------- 277

Query: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353
               +  DS+L+   +D+                  LVRGHAYSVTGL +V ++G+   L
Sbjct: 278 ----VTSDSELESM-TDKM-----------------LVRGHAYSVTGLQDVHYRGKMETL 315

Query: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413
           +R+RNPWG++EWNG+WSD  ++W  V  D + +L H+ TEDGEFWMSY+DF+ +FT LEI
Sbjct: 316 IRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHK-TEDGEFWMSYQDFLNNFTLLEI 374

Query: 414 CNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDD 473
           CNLT D L  D    W  +  EG W RG SAGGCRN P TFWTNPQ+++ L E DD  DD
Sbjct: 375 CNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDD 434

Query: 474 SE---VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNA 529
           +E   V+C+ LVALMQKN R  R+ GA L TIGF +Y VPKE    +  HL+K+FF    
Sbjct: 435 AEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQ 494

Query: 530 SKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTIS 589
               S+ + N REVS + RLPP EY+I+PST+EPH++ +F+LRVF+EK + S E+     
Sbjct: 495 DHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWEL----- 549

Query: 590 VDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE 649
                            D  N  ++L  ++ SE+                         +
Sbjct: 550 -----------------DEVNYAEQLQEEKVSED-------------------------D 567

Query: 650 EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS 709
             Q F ++FK +AG+  EI   EL+++LN +  K K  KT GF L++CR MI LMD DGS
Sbjct: 568 MDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGS 627

Query: 710 GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR 769
           GKL L EF  LW K+K W  IF+  D D SGT+NSYEMR  +  AG  LNN++  ++  R
Sbjct: 628 GKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVAR 687

Query: 770 YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 820
           YAD  + IDFDSFI CF+RL+ MF  F   D    G I L++ +WLQ+TM+
Sbjct: 688 YADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  646 bits (1667), Expect = 0.0
 Identities = 333/763 (43%), Positives = 463/763 (60%), Gaps = 104/763 (13%)

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
           F+ L ++CL+  VL+ DPEFP   ++L Y    P        +WKRP E+C +P+FI+ G
Sbjct: 32  FKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIVGG 91

Query: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
           A RTDICQG LGDCW LAAIA LTLN+ LL+RV+P DQ F ENYAGIFHFQFW+YGEWV+
Sbjct: 92  ATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEWVE 151

Query: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
           VVIDD LPT N QL+F  S   NEFWSALLEKAYAKL+G YEAL GG+T E  EDFTGG+
Sbjct: 152 VVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGI 211

Query: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295
                     S+ Y + K       ++  ++  G+ +      S     E I        
Sbjct: 212 ----------SEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQK---- 257

Query: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355
                                             LV+ HAYSVTG++EV F+G   KL+R
Sbjct: 258 ----------------------------------LVKSHAYSVTGVEEVNFQGHPEKLIR 283

Query: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415
           LRNPWG+VEW+G+WSD   +W+ +D   K  L  +V EDGEFWMS  DF+  F++LEICN
Sbjct: 284 LRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKV-EDGEFWMSLSDFVRQFSRLEICN 342

Query: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDS- 474
           L+ D+L S+++  W + +  G W RG +AGGC+N+P T+WTNPQ++++L E D+D ++S 
Sbjct: 343 LSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESI 402

Query: 475 -EVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASKA 532
            E  C+ L+ LMQKNRR  +++G  + +IG+A+Y+VPKE+  +   HL +DFFL     A
Sbjct: 403 GEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSA 462

Query: 533 RSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDR 592
           R+ TY+N+REVS R RLPP EY++VPST+EP ++GEF LRVFSEK+  + E+ + ++   
Sbjct: 463 RTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVA--- 519

Query: 593 PVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQ 652
                                                        +P P   DQE +   
Sbjct: 520 -----------------------------------------GNPYEPHPSEVDQEDD--- 535

Query: 653 QFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKL 712
           QFR +F+++AG D EI A+ LK +LN   +K  D+K  GF + +CR MI+L+D++G+G L
Sbjct: 536 QFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTL 595

Query: 713 NLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYAD 772
              EF  LW KI+ + +I+   D + SGTI+++EMR A+  AGF LN+Q+   I +RYA 
Sbjct: 596 GAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYAC 655

Query: 773 KHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 815
             + I+FDSF+ C +RLE +F+ F   D+D DG+++L++ EWL
Sbjct: 656 SKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score =  634 bits (1634), Expect = 0.0
 Identities = 309/309 (100%), Positives = 309/309 (100%)

Query: 513 MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 572
           MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR
Sbjct: 1   MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 60

Query: 573 VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 632
           VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK
Sbjct: 61  VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 120

Query: 633 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 692
           QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF
Sbjct: 121 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 180

Query: 693 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 752
           TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN
Sbjct: 181 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 240

Query: 753 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 812
           DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL
Sbjct: 241 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 300

Query: 813 EWLQLTMYA 821
           EWLQLTMYA
Sbjct: 301 EWLQLTMYA 309


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  480 bits (1236), Expect = e-135
 Identities = 279/793 (35%), Positives = 408/793 (51%), Gaps = 133/793 (16%)

Query: 59  KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFII 113
           +++E +   CL+  +L+ DP FP    +L Y Q  P         W RP E C  P+FI 
Sbjct: 30  QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFIC 89

Query: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173
           +  +RTD+CQG LG+CWFLAA A LTL   LL RV+P  Q F   YAG+FHFQ W++G W
Sbjct: 90  EDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFGRW 149

Query: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
           +DVV+DD LP    +L+F +S  RNEFW+ LLEKAYAKLHGSYE ++GG+  EA  DFTG
Sbjct: 150 MDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTG 209

Query: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293
           GV E   +R     ++  ++ A+ + SL+G +                            
Sbjct: 210 GVGEVLYLRQNSMGLFSALRHALAKESLVGATA--------------------------- 242

Query: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353
                     L  RG              E R   GLV+GHAYS+TG  +V     KV+L
Sbjct: 243 ----------LSDRG--------------EYRTEEGLVKGHAYSITGTHKVFLGFTKVRL 278

Query: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413
           +RLRNPWG VEW G+WSD    W  +  + +  L  +  EDGEFWM   DF+ HF  ++I
Sbjct: 279 LRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVK-KEDGEFWMELRDFLLHFDTVQI 337

Query: 414 CNLTADAL-QSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPD 472
           C+L+ + L  S +   W V   +GRWVRG ++GG +   +TFWTNPQ+RL LLE D++ D
Sbjct: 338 CSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDD 397

Query: 473 DSE---------------------VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPK 511
           + E                       C+ L++L+Q+NRR+ R  G +  T+GF ++++P+
Sbjct: 398 EDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPE 457

Query: 512 EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFIL 571
           E+ G     +    L    +A        R+V++R  L P  Y++VPST     E +F L
Sbjct: 458 ELLGLWDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTL 517

Query: 572 RVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPD 631
           RVFSE+R+ + E+++ IS D    +    P+           ELG++Q            
Sbjct: 518 RVFSERRHTAVEIDDVISADLQSLQGPYLPL-----------ELGLEQ------------ 554

Query: 632 KQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHG 691
                                    +F+++AG++ E+ A +L+ +L+  +   +  + H 
Sbjct: 555 -------------------------LFQELAGEEEELNASQLQALLSIAL---EPARAHT 586

Query: 692 FTLE--SCRSMIALMDTDGSGK-LNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMR 748
            T      R+   L+   G G+ L L  F  LW  +  WQ IF  +D D SGT+NSYE+R
Sbjct: 587 STPREIGLRTCEQLLQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELR 646

Query: 749 NAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIK 808
            A+N AGFHLNNQL   +T RY D  + +DF+ F+ C   L  +F         G+G+I 
Sbjct: 647 LALNAAGFHLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVIC 706

Query: 809 LNVLEWLQLTMYA 821
           L   +W+++  ++
Sbjct: 707 LTHRQWMEVATFS 719


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  444 bits (1141), Expect = e-124
 Identities = 272/769 (35%), Positives = 388/769 (50%), Gaps = 116/769 (15%)

Query: 58  EKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYS---QKFPIQFVWKRPPEICENPRFIID 114
           ++ FE L  +CL    L+ D  FP   +S+      QK P +  WKRPPE+  NP+F   
Sbjct: 27  QQDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFA 86

Query: 115 GANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWV 174
            A R D+CQG +GDCWFLAA+  L L+Q +L RV+P +QSF E YAGIF F FW YG WV
Sbjct: 87  KAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWV 146

Query: 175 DVVIDDCLPTYN-NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
            VVIDD LP     QLVF  S ++N FW ALLEKAYAKL GSYE L+ G  +EA+ DFTG
Sbjct: 147 PVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTG 206

Query: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293
           GV     + +A  +++ I+ +A    +L+GC    G  +                     
Sbjct: 207 GVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSGEKI--------------------- 245

Query: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353
           ++N L                                V GHAY++TG+ +V  K     L
Sbjct: 246 LENGL--------------------------------VEGHAYTLTGIRKVTCKHRPEYL 273

Query: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413
           V+LRNPWG+VEW G WSD    W  +   EK  L  +   DGEFWM+ +DF  HF  L I
Sbjct: 274 VKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRK-DNDGEFWMTLQDFKTHFVLLVI 332

Query: 414 CNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRN-FPDTFWTNPQYRLKLLEEDDDPD 472
           C LT   L  +  Q WT ++ EGRW +  +AGG R    DTFW NPQ+ L +   ++   
Sbjct: 333 CKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEGRR 392

Query: 473 DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKA 532
                CS LV+L+QK R + RK    L  IGF +Y + K  H +++ L  +FF  N   +
Sbjct: 393 SLRP-CSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNK-YHDDQRRLPPEFFQRNTPLS 449

Query: 533 RSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDR 592
           +   ++  +EVSQ   L P  Y+IVP   E HQ+ EF+LRVFS K    E   N+     
Sbjct: 450 QPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHIFYEIGSNS----- 504

Query: 593 PVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQ 652
                    ++F       +KE+                             DQ   + +
Sbjct: 505 --------GVVF-------SKEI----------------------------EDQNERQDE 521

Query: 653 QFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKL 712
            F   F++      EI A +L+ +LN +       +   F+LE+C+ ++AL+D + SG +
Sbjct: 522 FFTKFFEK----HPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTM 577

Query: 713 NLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYAD 772
           ++QEF  LW ++K  QK+F H     SG +N  ++  A+ +AG  L++ +  ++ +RY  
Sbjct: 578 SIQEFRDLWKQLKLSQKVF-HKQDRGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGG 636

Query: 773 KHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
             + +DF SFI   +R+E M   F    +DG GI  L   EW+ + +Y+
Sbjct: 637 PRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKGIY-LQKPEWMMMALYS 684


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  361 bits (927), Expect = 1e-99
 Identities = 210/548 (38%), Positives = 287/548 (52%), Gaps = 94/548 (17%)

Query: 57  KEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGA 116
           +++ +  L + C  +KVL+ DP FP  + SL+Y         WKRP  ICE+PR  +DG 
Sbjct: 9   EDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGI 68

Query: 117 NRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHFQFWRY 170
           +  D+ QG++G+CWF+AA + L   + L  +VIP       D      YAGIFHF FWR+
Sbjct: 69  SSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRF 128

Query: 171 GEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMED 230
           GEWVDVVIDD LPT NNQL++  SN RNEFW AL+EKAYAKL G Y+AL GGNT +A+ D
Sbjct: 129 GEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVD 188

Query: 231 FTGGVAEFFEIRDAP--------SDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLN 282
           FTGGV+E  ++ +          + +++ M K   RG L+  SI                
Sbjct: 189 FTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASI---------------- 232

Query: 283 MGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLD 342
                                           + +     E R+ACGLV+GHAY+VT + 
Sbjct: 233 --------------------------------KAVTAADMEARLACGLVKGHAYAVTDVR 260

Query: 343 EVP--------FKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED 394
           +V         FK EK+ ++RLRNPWG+ EWNG WSD  ++W  V K E+ ++   V +D
Sbjct: 261 KVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDD 320

Query: 395 GEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWV-----RGCSAGGCRN 449
           GEFWM++ED   +FT +  C +   +  S   +TW  +   G W      R    GGC N
Sbjct: 321 GEFWMTFEDVCRYFTDIIKCRVINTSHLSIH-KTWEEARLHGAWTLHEDPRQNRGGGCIN 379

Query: 450 FPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG-ASLFTIGFAIYE 508
             DTF+ NPQY    + E   P+D  +IC     + Q+ +R  R+ G      IGF IY+
Sbjct: 380 HKDTFFQNPQY----IFEVKKPEDEVLIC-----IQQRPKRSTRREGKGENLAIGFDIYK 430

Query: 509 VPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGE 568
           V +        LQ         KA S  YIN R V  R   P   YVI+P+T+EP   GE
Sbjct: 431 VEENRQYRMHSLQ--------HKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGE 482

Query: 569 FILRVFSE 576
           F+LRVF++
Sbjct: 483 FLLRVFTD 490


>gi|27765080 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  329 bits (844), Expect = 6e-90
 Identities = 156/156 (100%), Positives = 156/156 (100%)

Query: 666 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 725
           MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 726 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 785
           AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 786 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
           FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|27765078 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  329 bits (844), Expect = 6e-90
 Identities = 156/156 (100%), Positives = 156/156 (100%)

Query: 666 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 725
           MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 726 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 785
           AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 786 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821
           FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  300 bits (769), Expect = 3e-81
 Identities = 223/783 (28%), Positives = 354/783 (45%), Gaps = 142/783 (18%)

Query: 53  IIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSL---FYSQKFPIQFVWKRPPEICENP 109
           II  K++ F  L   CL     + D  FP  ++S+      +K     +WKRP ++   P
Sbjct: 13  IIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGP 72

Query: 110 -RFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFW 168
             FI+D  +R DI QG   DCWFLAA+  LT N     +++   QSF   YAGIF F+FW
Sbjct: 73  PHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFW 131

Query: 169 RYGEWVDVVIDDCLPTYNNQLVFTKSNHRN-EFWSALLEKAYAKLHGSYEALKGGNTTEA 227
           + G+WV+VVIDD LP   ++ +F +  H+N EFW  LLEKAYAKL GSY  L  G   +A
Sbjct: 132 QCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDA 191

Query: 228 MEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELI 287
           + D TGGV     +  +P D+ K +K A + GSL+ C+           +PSG       
Sbjct: 192 LVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCA-----------TPSG------- 233

Query: 288 ARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK 347
                                          P      M  GLV  HAY+VTG +++ ++
Sbjct: 234 -------------------------------PTDTAQAMENGLVSLHAYTVTGAEQIQYR 262

Query: 348 GEKVKLVRLRNP--WGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFI 405
               +++ L NP  WG+ EW G WSD  ++W       K++L H+  EDGEFWMS +DF 
Sbjct: 263 RGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQL-HKKREDGEFWMSCQDFQ 321

Query: 406 YHFTKLEICNLTADALQSDKL--QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463
             F  + IC+     L       + W+  +   + + G +AGG RN       + Q+   
Sbjct: 322 QKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-------DAQFNFS 374

Query: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 523
           + E  +    + V+C  +       + +D K     F + F +     +    ++     
Sbjct: 375 VQEPME--GTNVVVCVTVAVTPSNLKAEDAK-----FPLDFQVILAGSQRF--REKFPPV 425

Query: 524 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 583
           FF    +  +S      R  +  + L P  YV+V  T    +  EF+LR+F +  +    
Sbjct: 426 FFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLLRIFLKMPDSDRH 483

Query: 584 VENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS 643
           + +  ++                                         + K SP      
Sbjct: 484 LSSHFNL-----------------------------------------RMKGSP------ 496

Query: 644 SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLN--TVVNKHKDLKTHGFTLESCRSMI 701
               SE   Q ++IF + A   ++I A +L+ +LN   +     D+    F+L+ CRS++
Sbjct: 497 ----SEHGSQ-QSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDM----FSLDECRSLV 547

Query: 702 ALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDA----GFH 757
           ALM+   +G+L+ +EF  LW ++  +Q +F+   T   G + S ++  A+ +     G  
Sbjct: 548 ALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQT-SPGVLLSSDLWKAIENTDFLRGIF 606

Query: 758 LNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQL 817
           ++ +L  ++T+RY+D    + F S +C  +RLE M + F    KDG G+  L  +EW+ L
Sbjct: 607 ISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLY-LTEMEWMSL 665

Query: 818 TMY 820
            MY
Sbjct: 666 VMY 668


>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score =  293 bits (749), Expect = 6e-79
 Identities = 185/553 (33%), Positives = 281/553 (50%), Gaps = 95/553 (17%)

Query: 52  PIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRF 111
           P+   K + +++L ++C++   L+ DP F P+  SLFY++  P + VWKRP +IC++P  
Sbjct: 4   PLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHL 63

Query: 112 IIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHF 165
           I+   +   + QG LG    ++A +CL + +    + IP+      D    E YAGIFHF
Sbjct: 64  IVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHF 123

Query: 166 QFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTT 225
           +FW +GEW +VVIDD LPT N  LVF+ S   NEFW+ALLEKAYAKL G YEAL G   T
Sbjct: 124 RFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTIT 183

Query: 226 EAMEDFTGGVAEFFEIR-----DAPSDMYKI---MKKAIERGSLMGCSIDDGTNMTYGTS 277
           + + DFTG +AE  +++     +   + YK+   + K   +G L+ CSI+         S
Sbjct: 184 DIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIE---------S 234

Query: 278 PSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYS 337
           P+                                         + E     GL++GH Y+
Sbjct: 235 PN---------------------------------------QEEQEVETDWGLLKGHTYT 255

Query: 338 VTGLDEV--------PFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQH 389
           +T + ++         F  EKV +VRLRNP G+ EW+G WS+  ++W  +   ++  L  
Sbjct: 256 MTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGL 315

Query: 390 QVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDK-----LQTWTVSVNEGRWVRGCSA 444
            +++DGEFWMS EDF  +F KL +C    + +   K     L  WTV  ++    R   +
Sbjct: 316 VMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVD-DDPLMNR---S 371

Query: 445 GGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG-ASLFTIG 503
           GGC N  DTF  NPQY   +      P+D   +   +++L QK+ R  R++G    + IG
Sbjct: 372 GGCYNNRDTFLQNPQYIFTV------PEDGHKV---IMSLQQKDLRTYRRMGRPDNYIIG 422

Query: 504 FAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEP 563
           F +++V         H      LY   +A + TYI+ R V     L    YV+VP+ ++ 
Sbjct: 423 FELFKVEMNRKFRLHH------LYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQH 476

Query: 564 HQEGEFILRVFSE 576
            +  EF+LR+FSE
Sbjct: 477 GRTSEFLLRIFSE 489


>gi|4502565 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  224 bits (572), Expect = 2e-58
 Identities = 106/192 (55%), Positives = 140/192 (72%), Gaps = 6/192 (3%)

Query: 636 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 689
           +P+P P  +        ESEE +QFR +F Q+AGDDME+ A EL  +LN VV +H DLKT
Sbjct: 77  NPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKT 136

Query: 690 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 749
            GF +++CRSM+A+MD+D +GKL  +EF +LWN IK WQ I+K +DTD+SGTI S E+  
Sbjct: 137 DGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPG 196

Query: 750 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 809
           A   AGFHLN  LY++I  RY+D+  N+DFD+FI C VRL+ MFRAF + DKDG G I++
Sbjct: 197 AFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQV 256

Query: 810 NVLEWLQLTMYA 821
           N+ EWLQLTMY+
Sbjct: 257 NIQEWLQLTMYS 268


>gi|51599151 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  224 bits (572), Expect = 2e-58
 Identities = 106/192 (55%), Positives = 140/192 (72%), Gaps = 6/192 (3%)

Query: 636 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 689
           +P+P P  +        ESEE +QFR +F Q+AGDDME+ A EL  +LN VV +H DLKT
Sbjct: 77  NPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKT 136

Query: 690 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 749
            GF +++CRSM+A+MD+D +GKL  +EF +LWN IK WQ I+K +DTD+SGTI S E+  
Sbjct: 137 DGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPG 196

Query: 750 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 809
           A   AGFHLN  LY++I  RY+D+  N+DFD+FI C VRL+ MFRAF + DKDG G I++
Sbjct: 197 AFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQV 256

Query: 810 NVLEWLQLTMYA 821
           N+ EWLQLTMY+
Sbjct: 257 NIQEWLQLTMYS 268


>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score =  215 bits (548), Expect = 1e-55
 Identities = 166/533 (31%), Positives = 242/533 (45%), Gaps = 83/533 (15%)

Query: 74  LYVDPEFPPDETSLFYSQKFPI-----QFVWKRPPEICENPRFIIDGANRTDICQGELGD 128
           L+ D  FP  ++SLF     P+        W+RP EIC  PR   D      + QG LGD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 129 CWFLAAIACLTLNQHLLFRVIPHDQSFI--ENYAGIFHFQFWRYGEWVDVVIDDCLPTYN 186
           CWFL A A L  ++HLL +VIP  Q     + Y G F  + W++G WV+V  DD LP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 187 NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPS 246
            +L F++    + FW  LLEK YAK+HGSYE L  G   +A+ D TGG+A          
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLA---------- 182

Query: 247 DMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDP 306
                     ER +L G +   G          G        +++   D  L+    L P
Sbjct: 183 ----------ERWNLKGVAGSGGQQ-----DRPGRWEHRTCRQLLHLKDQCLISCCVLSP 227

Query: 307 RGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK-GEKVKLVRLRNPWGQVEW 365
           R                   A  L   HA+ V+ L E+  + G+ + L+R++NPWG+  W
Sbjct: 228 RAG-----------------ARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCW 270

Query: 366 NGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA----- 420
            G W +  + WS VD    + L  Q+ ++GEFW+  E+F+  F +L +     +A     
Sbjct: 271 QGLWREGGEGWSQVDAAVASELLSQL-QEGEFWVEEEEFLREFDELTVGYPVTEAGHLQS 329

Query: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
           L +++L   T ++  G WV+G SAGGCRN    F +NP++ L++ E       SEV    
Sbjct: 330 LYTERLLCHTRAL-PGAWVKGQSAGGCRN-NSGFPSNPKFWLRVSE------PSEV---- 377

Query: 481 LVALMQKNRRKDRK-LGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKAR------ 533
            +A++Q++R       G +   +G +           K +      L+   K R      
Sbjct: 378 YIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRV 437

Query: 534 --------SKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 578
                   +  +   REV  R  L P  Y+ VPST+     GEF+LRVFS  R
Sbjct: 438 LSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGR 490



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 43/145 (29%), Positives = 60/145 (41%), Gaps = 16/145 (11%)

Query: 429 WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKN 488
           W      G W  G +AGG RNF  ++ TNP +   +      P+     C   + L Q  
Sbjct: 514 WGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV------PEGPGPRC-VRITLHQHC 565

Query: 489 RRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFR 548
           R  D +       IGF I++VP+   G  Q       L          +   +EVS+   
Sbjct: 566 RPSDTEF----HPIGFHIFQVPEG--GRSQDAPP--LLLQEPLLSCVPHRYAQEVSRLCL 617

Query: 549 LPPSEYVIVPSTYEPHQEGEFILRV 573
           LP   Y +VPSTY P  EG F + +
Sbjct: 618 LPAGTYKVVPSTYLPDTEGAFTVTI 642


>gi|14161692 calpain small subunit 2 [Homo sapiens]
          Length = 248

 Score =  210 bits (534), Expect = 5e-54
 Identities = 96/192 (50%), Positives = 140/192 (72%), Gaps = 6/192 (3%)

Query: 636 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 689
           +P+P P           ESEE ++FR  F Q+AG DME+ A +L  +LN V++KHKDLKT
Sbjct: 57  TPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKT 116

Query: 690 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 749
            GF+L++CRS++++MD+D +GKL  +EF +LWN IK WQ ++K YD D SG++ S ++R 
Sbjct: 117 DGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRG 176

Query: 750 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 809
           A+  AGF LN QLY +I  RYA++  ++DF++FI C VRL+ MFRAF + D+D DG+I++
Sbjct: 177 ALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQV 236

Query: 810 NVLEWLQLTMYA 821
           ++ EWLQLTMY+
Sbjct: 237 SIKEWLQLTMYS 248


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  209 bits (531), Expect = 1e-53
 Identities = 164/534 (30%), Positives = 242/534 (45%), Gaps = 93/534 (17%)

Query: 74  LYVDPEFPPDETSLFYSQKFPI-----QFVWKRPPEICENPRFIIDGANRTDICQGELGD 128
           L+ D  FP  ++SLF     P+        W+RP EIC  PR   D      + QG LGD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 129 CWFLAAIACLTLNQHLLFRVIPHDQSFI--ENYAGIFHFQFWRYGEWVDVVIDDCLPTYN 186
           CWFL A A L  ++HLL +VIP  Q     + Y G F  + W++G WV+V  DD LP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 187 NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPS 246
            +L F++    + FW  LLEK YAK+HGSYE L  G   +A+ D TGG+A          
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLA---------- 182

Query: 247 DMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDP 306
                     ER +L G +   G          G        +++   D  L+    L P
Sbjct: 183 ----------ERWNLKGVAGSGGQQ-----DRPGRWEHRTCRQLLHLKDQCLISCCVLSP 227

Query: 307 RGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK-GEKVKLVRLRNPWGQVEW 365
           R                   A  L   HA+ V+ L E+  + G+ + L+R++NPWG+  W
Sbjct: 228 RAG-----------------ARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCW 270

Query: 366 NGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA----- 420
            G W +  + WS VD    + L  Q+ ++GEFW+  E+F+  F +L +     +A     
Sbjct: 271 QGLWREGGEGWSQVDAAVASELLSQL-QEGEFWVEEEEFLREFDELTVGYPVTEAGHLQS 329

Query: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480
           L +++L   T ++  G WV+G SAGGCRN    F +NP++ L++ E       SEV    
Sbjct: 330 LYTERLLCHTRAL-PGAWVKGQSAGGCRN-NSGFPSNPKFWLRVSE------PSEV---- 377

Query: 481 LVALMQKNR-------RKDRKL--------------GASLFTIGFAIYEVPKEMHGNKQH 519
            +A++Q++R        + R L              G     +G  +++VP+   G  Q 
Sbjct: 378 YIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVPE--GGRSQD 435

Query: 520 LQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRV 573
                 L          +   +EVS+   LP   Y +VPSTY P  EG F + +
Sbjct: 436 APP--LLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTI 487


>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score =  157 bits (398), Expect = 3e-38
 Identities = 118/385 (30%), Positives = 164/385 (42%), Gaps = 77/385 (20%)

Query: 55  GVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQF---VWKRPPEI-CENPR 110
           G  +  +E +   C E  V +VD  FPP   S+ +     +Q     W RP EI C   R
Sbjct: 468 GEAKALWENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFR 527

Query: 111 ------FIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFH 164
                  +      +DI QG LG+CWFL+A+A L     L+ RV+       E   G + 
Sbjct: 528 DHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQ 584

Query: 165 FQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNT 224
            +  + G W  V++DD LP      +      R + W AL+EKA AKLHGSY AL+ G  
Sbjct: 585 VRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRA 644

Query: 225 TEAMEDFTGGVAEFFEI-------RDAPSDMYKIMKKAI---ERGSLMGCSIDDGTNMTY 274
            E +   TG   E   +       R+ P D   I  K +   E G LMG S   G NM  
Sbjct: 645 IEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGG-NM-- 701

Query: 275 GTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGH 334
                              +D+S  +   L PR                          H
Sbjct: 702 ------------------KVDDSAYESLGLRPR--------------------------H 717

Query: 335 AYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED 394
           AYS+  + +V    +  +L+RLRNPWG+  WNGSWSD W  W       +  L    + +
Sbjct: 718 AYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PGHLRGELMPHGSSE 770

Query: 395 GEFWMSYEDFIYHFTKLEICNLTAD 419
           G FWM Y DF+ +F  ++IC + +D
Sbjct: 771 GVFWMEYGDFVRYFDSVDICKVHSD 795


>gi|38679884 sorcin isoform b [Homo sapiens]
          Length = 183

 Score =  102 bits (255), Expect = 1e-21
 Identities = 57/181 (31%), Positives = 93/181 (51%), Gaps = 8/181 (4%)

Query: 641 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCR 698
           PG      + Q      F  +AG D +I ADEL++ L    +   +K      F LE+CR
Sbjct: 7   PGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCR 61

Query: 699 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 758
            M++++D D SG +   EF  LW  +  W++ F  +DTD+SGT++  E++ A+   GF L
Sbjct: 62  LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRL 121

Query: 759 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 818
           + Q  + I  RY+  +  I FD +I C V+L  +  +F   D    G++     +++Q  
Sbjct: 122 SPQAVNSIAKRYS-TNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCV 180

Query: 819 M 819
           M
Sbjct: 181 M 181


>gi|4507207 sorcin isoform a [Homo sapiens]
          Length = 198

 Score =  102 bits (255), Expect = 1e-21
 Identities = 57/181 (31%), Positives = 93/181 (51%), Gaps = 8/181 (4%)

Query: 641 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCR 698
           PG      + Q      F  +AG D +I ADEL++ L    +   +K      F LE+CR
Sbjct: 22  PGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCR 76

Query: 699 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 758
            M++++D D SG +   EF  LW  +  W++ F  +DTD+SGT++  E++ A+   GF L
Sbjct: 77  LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRL 136

Query: 759 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 818
           + Q  + I  RY+  +  I FD +I C V+L  +  +F   D    G++     +++Q  
Sbjct: 137 SPQAVNSIAKRYS-TNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCV 195

Query: 819 M 819
           M
Sbjct: 196 M 196


>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
           sapiens]
          Length = 217

 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 59/179 (32%), Positives = 88/179 (49%), Gaps = 4/179 (2%)

Query: 641 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSM 700
           P  SD  S         F  +AG D E+ A+EL++ L        +     F+LE+CR M
Sbjct: 41  PAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLT---QSGINGTYSPFSLETCRIM 97

Query: 701 IALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNN 760
           IA++D D +GK+    F  LW  + AW++ F   D D SGT+  +E+R A+   G+ L+ 
Sbjct: 98  IAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSP 157

Query: 761 QLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 819
           Q    I  RY+ K+  I FD ++ C V+L  +   F   D    G       ++LQ TM
Sbjct: 158 QTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215


>gi|7019485 programmed cell death 6 [Homo sapiens]
          Length = 191

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 51/187 (27%), Positives = 94/187 (50%), Gaps = 10/187 (5%)

Query: 634 KQSPQPQPGSSDQESEEQQQFR-NIFKQIAGDDMEICAD-ELKKVLNTVVNKHKDLKTHG 691
           +  P   PG +   +   Q F  N+F+++  D   + +D EL++ L+             
Sbjct: 7   RPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGT-------WTP 59

Query: 692 FTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAV 751
           F   + RS+I++ D +    +N  EF  +W  I  WQ +F+ YD D SG I+  E++ A+
Sbjct: 60  FNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQAL 119

Query: 752 NDAGFHLNNQLYDIITMRY-ADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLN 810
           +  G+ L++Q +DI+  ++       I FD FI   + L+ +   F  +D D DG I+++
Sbjct: 120 SGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVS 179

Query: 811 VLEWLQL 817
             ++L +
Sbjct: 180 YEQYLSM 186


>gi|7656959 calpain 7 [Homo sapiens]
          Length = 813

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 81/325 (24%), Positives = 138/325 (42%), Gaps = 69/325 (21%)

Query: 99  WKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLT-----LNQHLLFRVI-PHD 152
           W RP ++  NP  I    +   I Q  + DC F+A++A         N+ L+  +I P +
Sbjct: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319

Query: 153 QSFIENY--AGIFHFQFWRYGEWVDVVIDDCLPT-YNNQLVFTKSNHRNEFWSALLEKAY 209
           +     Y   G +  +    G    V+IDD LP  +  +L+ + SN+++E W +L+EKAY
Sbjct: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379

Query: 210 AKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDG 269
            K+ G Y+   G N+   +   TG + E   +    SD     K             D+ 
Sbjct: 380 MKVMGGYD-FPGSNSNIDLHALTGWIPERIAMH---SDSQTFSK-------------DNS 422

Query: 270 TNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACG 329
             M Y     G              D  +   + +      E+                G
Sbjct: 423 FRMLYQRFHKG--------------DVLITASTGMMTEAEGEK---------------WG 453

Query: 330 LVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDR-WKDWS-----FVDKDE 383
           LV  HAY+V  LD   FKG  ++ ++L+NPW  + W G +S+   K+W+     +++ D 
Sbjct: 454 LVPTHAYAV--LDIREFKG--LRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDP 509

Query: 384 KARLQHQVTEDGEFWMSYEDFIYHF 408
           +     Q  ++G FW+S++D   ++
Sbjct: 510 RTA---QKIDNGIFWISWDDLCQYY 531



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 37/137 (27%), Positives = 53/137 (38%), Gaps = 32/137 (23%)

Query: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495
           G+W  G SAGGC NF +T   NP Y+  +          E     L+ L           
Sbjct: 694 GKW-SGQSAGGCGNFQETHKNNPIYQFHI----------EKTGPLLIELR---------- 732

Query: 496 GASLFTIGFAIYEVPK-EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEY 554
           G   +++GF +  V      G    L+K    Y         Y+ +  +      P   +
Sbjct: 733 GPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFC----YLELENI------PSGIF 782

Query: 555 VIVPSTYEPHQEGEFIL 571
            I+PST+ P QEG F L
Sbjct: 783 NIIPSTFLPKQEGPFFL 799


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,954,824
Number of Sequences: 37866
Number of extensions: 1642209
Number of successful extensions: 7804
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 104
Number of HSP's that attempted gapping in prelim test: 7401
Number of HSP's gapped (non-prelim): 390
length of query: 821
length of database: 18,247,518
effective HSP length: 111
effective length of query: 710
effective length of database: 14,044,392
effective search space: 9971518320
effective search space used: 9971518320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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