Guide to the Human Genome
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Search of human proteins with 4507565

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507565 tumor necrosis factor receptor superfamily, member
11a precursor [Homo sapiens]
         (616 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507565 tumor necrosis factor receptor superfamily, member 11...  1305   0.0  
gi|4507581 CD40 antigen isoform 1 precursor [Homo sapiens]            150   3e-36
gi|23312371 CD40 antigen isoform 2 precursor [Homo sapiens]           135   1e-31
gi|4505039 lymphotoxin beta receptor [Homo sapiens]                   109   7e-24
gi|4507577 tumor necrosis factor receptor 2 precursor [Homo sapi...   105   9e-23
gi|148743793 osteoprotegerin precursor [Homo sapiens]                 103   6e-22
gi|14790170 tumor necrosis factor receptor superfamily, member 6...    92   1e-18
gi|4507585 tumor necrosis factor receptor superfamily, member 6b...    92   1e-18
gi|4507579 tumor necrosis factor receptor superfamily, member 4 ...    89   1e-17
gi|23200041 tumor necrosis factor receptor superfamily, member 1...    79   2e-14
gi|7657039 tumor necrosis factor receptor superfamily, member 21...    77   5e-14
gi|5730095 tumor necrosis factor receptor superfamily, member 9 ...    74   5e-13
gi|4505393 nerve growth factor receptor precursor [Homo sapiens]       64   3e-10
gi|23200023 tumor necrosis factor receptor superfamily, member 2...    59   2e-08
gi|23200021 tumor necrosis factor receptor superfamily, member 2...    59   2e-08
gi|89142745 tumor necrosis factor receptor superfamily, member 2...    59   2e-08
gi|4507569 tumor necrosis factor receptor superfamily, member 25...    59   2e-08
gi|68348711 tumor necrosis factor receptor superfamily, member 8...    55   2e-07
gi|23510423 tumor necrosis factor receptor superfamily, member 6...    54   6e-07
gi|23510421 tumor necrosis factor receptor superfamily, member 6...    54   6e-07
gi|4507583 tumor necrosis factor receptor superfamily, member 6 ...    54   6e-07
gi|4759246 tumor necrosis factor receptor superfamily, member 18...    52   1e-06
gi|23238197 tumor necrosis factor receptor superfamily, member 1...    52   1e-06
gi|4507575 tumor necrosis factor receptor 1 precursor [Homo sapi...    50   6e-06
gi|4507587 tumor necrosis factor receptor superfamily, member 7 ...    47   7e-05
gi|7710121 engrailed homeobox 2 [Homo sapiens]                         44   3e-04
gi|4557733 latent transforming growth factor beta binding protei...    44   6e-04
gi|11140823 X-linked ectodysplasin receptor [Homo sapiens]             41   0.003
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap...    40   0.006
gi|23238194 tumor necrosis factor receptor superfamily, member 1...    39   0.014

>gi|4507565 tumor necrosis factor receptor superfamily, member 11a
           precursor [Homo sapiens]
          Length = 616

 Score = 1305 bits (3376), Expect = 0.0
 Identities = 616/616 (100%), Positives = 616/616 (100%)

Query: 1   MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKC 60
           MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKC
Sbjct: 1   MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKC 60

Query: 61  TTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHW 120
           TTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHW
Sbjct: 61  TTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHW 120

Query: 121 SQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGK 180
           SQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGK
Sbjct: 121 SQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGK 180

Query: 181 RVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGK 240
           RVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGK
Sbjct: 181 RVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGK 240

Query: 241 ALTANLWHWINEACGRLSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMC 300
           ALTANLWHWINEACGRLSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMC
Sbjct: 241 ALTANLWHWINEACGRLSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMC 300

Query: 301 YPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQL 360
           YPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQL
Sbjct: 301 YPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQL 360

Query: 361 LFLTEPGSKSTPPFSEPLEVGENDSLSQCFTGTQSTVGSESCNCTEPLCRTDWTPMSSEN 420
           LFLTEPGSKSTPPFSEPLEVGENDSLSQCFTGTQSTVGSESCNCTEPLCRTDWTPMSSEN
Sbjct: 361 LFLTEPGSKSTPPFSEPLEVGENDSLSQCFTGTQSTVGSESCNCTEPLCRTDWTPMSSEN 420

Query: 421 YLQKEVDSGHCPHWAASPSPNWADVCTGCRNPPGEDCEPLVGSPKRGPLPQCAYGMGLPP 480
           YLQKEVDSGHCPHWAASPSPNWADVCTGCRNPPGEDCEPLVGSPKRGPLPQCAYGMGLPP
Sbjct: 421 YLQKEVDSGHCPHWAASPSPNWADVCTGCRNPPGEDCEPLVGSPKRGPLPQCAYGMGLPP 480

Query: 481 EEEASRTEARDQPEDGADGRLPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVM 540
           EEEASRTEARDQPEDGADGRLPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVM
Sbjct: 481 EEEASRTEARDQPEDGADGRLPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVM 540

Query: 541 NFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLRE 600
           NFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLRE
Sbjct: 541 NFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLRE 600

Query: 601 PEKASRPVQEQGGAKA 616
           PEKASRPVQEQGGAKA
Sbjct: 601 PEKASRPVQEQGGAKA 616


>gi|4507581 CD40 antigen isoform 1 precursor [Homo sapiens]
          Length = 277

 Score =  150 bits (380), Expect = 3e-36
 Identities = 80/216 (37%), Positives = 109/216 (50%), Gaps = 2/216 (0%)

Query: 14  LLLLCALLARLQVALQIAPPCTS-EKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCG 72
           L L C L   L  A+   PP    EK Y    +CC+ C+PG+ + S CT  +++ CLPCG
Sbjct: 4   LPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCG 63

Query: 73  PDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYH-WSQDCECCRRNT 131
             E+LD+WN E  C  HK CD    L     G S T   C C  G+H  S+ CE C  + 
Sbjct: 64  ESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHR 123

Query: 132 ECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSD 191
            C+PG G +       DT+C+PC  G+FS+  S+ +KC PWT+C      V+  GT K+D
Sbjct: 124 SCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTD 183

Query: 192 AVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVA 227
            VC      R     P ++     ILL+   +  VA
Sbjct: 184 VVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVA 219


>gi|23312371 CD40 antigen isoform 2 precursor [Homo sapiens]
          Length = 203

 Score =  135 bits (339), Expect = 1e-31
 Identities = 65/162 (40%), Positives = 87/162 (53%), Gaps = 2/162 (1%)

Query: 14  LLLLCALLARLQVALQIAPPCTS-EKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCG 72
           L L C L   L  A+   PP    EK Y    +CC+ C+PG+ + S CT  +++ CLPCG
Sbjct: 4   LPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCG 63

Query: 73  PDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYH-WSQDCECCRRNT 131
             E+LD+WN E  C  HK CD    L     G S T   C C  G+H  S+ CE C  + 
Sbjct: 64  ESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHR 123

Query: 132 ECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWT 173
            C+PG G +       DT+C+PC  G+FS+  S+ +KC PWT
Sbjct: 124 SCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWT 165



 Score = 36.2 bits (82), Expect = 0.091
 Identities = 21/72 (29%), Positives = 31/72 (43%), Gaps = 4/72 (5%)

Query: 125 ECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCT-FLGKRVE 183
           +CC   + C PG           +T C PC    F D ++    C     C   LG RV+
Sbjct: 36  QCC---SLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQ 92

Query: 184 HHGTEKSDAVCS 195
             GT ++D +C+
Sbjct: 93  QKGTSETDTICT 104


>gi|4505039 lymphotoxin beta receptor [Homo sapiens]
          Length = 435

 Score =  109 bits (273), Expect = 7e-24
 Identities = 73/230 (31%), Positives = 106/230 (46%), Gaps = 18/230 (7%)

Query: 14  LLLLCALLARLQVALQIAPPCTSE---------KHYEHLGR-CCNKCEPGKYMSSKCTTT 63
           +L L  LLA  Q   Q  PP  SE         ++YE   R CC++C PG Y+S+KC+  
Sbjct: 18  VLGLFGLLAASQP--QAVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVSAKCSRI 75

Query: 64  SDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYH---W 120
            D+VC  C  + Y + WN    C L + CD    L  +    S    +C C  G     W
Sbjct: 76  RDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAW 135

Query: 121 SQDCECCRRNTECAPGLGAQHPLQLNK-DTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLG 179
           + +C  C   ++C PG  A+   ++ K +  C PC AG+F +  S + +C+P T C   G
Sbjct: 136 ALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQG 195

Query: 180 KRVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAI 229
                 GT +SD  C +  P    P E    +  L +LL  A   L+A +
Sbjct: 196 LVEAAPGTAQSDTTCKN--PLEPLPPEMSGTMLMLAVLLPLAFFLLLATV 243


>gi|4507577 tumor necrosis factor receptor 2 precursor [Homo
           sapiens]
          Length = 461

 Score =  105 bits (263), Expect = 9e-23
 Identities = 64/186 (34%), Positives = 84/186 (45%), Gaps = 13/186 (6%)

Query: 34  CTSEKHYEHLGR-CCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCL-LHKV 91
           C   ++Y+   + CC+KC PG++    CT TSD+VC  C    Y   WN   +CL     
Sbjct: 40  CRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSR 99

Query: 92  CDTGKALVAVVAGNSTTPRRCACTAGYHWS----QDCECCRRNTECAPGLGAQHPLQLNK 147
           C + +  V   A      R C C  G++ +    + C  C    +C PG G   P     
Sbjct: 100 CSSDQ--VETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETS 157

Query: 148 DTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSSLPARK-PPNE 206
           D VCKPC  G FS+  SSTD CRP   C      V   G    DAVC+S+ P R   P  
Sbjct: 158 DVVCKPCAPGTFSNTTSSTDICRPHQICNV----VAIPGNASMDAVCTSTSPTRSMAPGA 213

Query: 207 PHVYLP 212
            H+  P
Sbjct: 214 VHLPQP 219


>gi|148743793 osteoprotegerin precursor [Homo sapiens]
          Length = 401

 Score =  103 bits (256), Expect = 6e-22
 Identities = 64/190 (33%), Positives = 85/190 (44%), Gaps = 13/190 (6%)

Query: 16  LLCALLARLQVALQIAPPCTSEKHYEHLGR------CCNKCEPGKYMSSKCTTTSDSVCL 69
           LLC  L  L ++++     T    Y H          C+KC PG Y+   CT    +VC 
Sbjct: 4   LLCCALVFLDISIKWTTQETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCA 63

Query: 70  PCGPDEYLDSWNEEDKCLL-HKVCDTGKALVAVVAG-NSTTPRRCACTAGYHWSQDCECC 127
           PC    Y DSW+  D+CL    VC   K L  V    N T  R C C  G +   + E C
Sbjct: 64  PCPDHYYTDSWHTSDECLYCSPVC---KELQYVKQECNRTHNRVCECKEGRYL--EIEFC 118

Query: 128 RRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGT 187
            ++  C PG G        ++TVCK C  G+FS+  SS   CR  TNC+  G  +   G 
Sbjct: 119 LKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKGN 178

Query: 188 EKSDAVCSSS 197
              D +CS +
Sbjct: 179 ATHDNICSGN 188


>gi|14790170 tumor necrosis factor receptor superfamily, member 6b
           [Homo sapiens]
          Length = 300

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 48/150 (32%), Positives = 72/150 (48%), Gaps = 3/150 (2%)

Query: 47  CNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNS 106
           C +C PG ++   C   S + C PC P  Y   WN  ++C    V   G+      A ++
Sbjct: 49  CAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVL-CGEREEEARACHA 107

Query: 107 TTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSST 166
           T  R C C  G+        C  +  C PG G   P   +++T C+PC  G FS + SS+
Sbjct: 108 THNRACRCRTGFF--AHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSS 165

Query: 167 DKCRPWTNCTFLGKRVEHHGTEKSDAVCSS 196
           ++C+P  NCT LG  +   G+   D +C+S
Sbjct: 166 EQCQPHRNCTALGLALNVPGSSSHDTLCTS 195



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 9/94 (9%)

Query: 40  YEHLGRCCN--KCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKA 97
           + H G C     C PG  + +  T + ++ C PC P  +  S +  ++C  H+ C T   
Sbjct: 120 FAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNC-TALG 178

Query: 98  LVAVVAGNSTTPRRCACTAGYHWS------QDCE 125
           L   V G+S+    C    G+  S      ++CE
Sbjct: 179 LALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECE 212


>gi|4507585 tumor necrosis factor receptor superfamily, member 6b
           [Homo sapiens]
          Length = 300

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 48/150 (32%), Positives = 72/150 (48%), Gaps = 3/150 (2%)

Query: 47  CNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNS 106
           C +C PG ++   C   S + C PC P  Y   WN  ++C    V   G+      A ++
Sbjct: 49  CAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVL-CGEREEEARACHA 107

Query: 107 TTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSST 166
           T  R C C  G+        C  +  C PG G   P   +++T C+PC  G FS + SS+
Sbjct: 108 THNRACRCRTGFF--AHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSS 165

Query: 167 DKCRPWTNCTFLGKRVEHHGTEKSDAVCSS 196
           ++C+P  NCT LG  +   G+   D +C+S
Sbjct: 166 EQCQPHRNCTALGLALNVPGSSSHDTLCTS 195



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 9/94 (9%)

Query: 40  YEHLGRCCN--KCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKA 97
           + H G C     C PG  + +  T + ++ C PC P  +  S +  ++C  H+ C T   
Sbjct: 120 FAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNC-TALG 178

Query: 98  LVAVVAGNSTTPRRCACTAGYHWS------QDCE 125
           L   V G+S+    C    G+  S      ++CE
Sbjct: 179 LALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECE 212


>gi|4507579 tumor necrosis factor receptor superfamily, member 4
           precursor [Homo sapiens]
          Length = 277

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 70/210 (33%), Positives = 91/210 (43%), Gaps = 36/210 (17%)

Query: 1   MAPRARR--RRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSS 58
           M   ARR  R P  ALLLL      L ++      C  +  Y    RCC++C PG  M S
Sbjct: 1   MCVGARRLGRGPCAALLLL-----GLGLSTVTGLHCVGDT-YPSNDRCCHECRPGNGMVS 54

Query: 59  KCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGY 118
           +C+ + ++VC PCGP  Y D  + +  C     C+            S + R+  CTA  
Sbjct: 55  RCSRSQNTVCRPCGPGFYNDVVSSK-PCKPCTWCNL----------RSGSERKQLCTA-- 101

Query: 119 HWSQDCEC-CRRNTECAPGLGAQHPLQLNKDTV-CKPCLAGYFSDAFSSTDKCRPWTNCT 176
             +QD  C CR  T+         PL   K  V C PC  G+FS        C+PWTNCT
Sbjct: 102 --TQDTVCRCRAGTQ---------PLDSYKPGVDCAPCPPGHFSP--GDNQACKPWTNCT 148

Query: 177 FLGKRVEHHGTEKSDAVCSSSLPARKPPNE 206
             GK      +  SDA+C    P    P E
Sbjct: 149 LAGKHTLQPASNSSDAICEDRDPPATQPQE 178


>gi|23200041 tumor necrosis factor receptor superfamily, member 14
           precursor [Homo sapiens]
          Length = 283

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 46/152 (30%), Positives = 66/152 (43%), Gaps = 5/152 (3%)

Query: 31  APPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHK 90
           A P   E  Y     CC KC PG  +   C   + +VC PC P  Y+   N   KCL  +
Sbjct: 38  ALPSCKEDEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQ 97

Query: 91  VCDTGKALVAVVAGNSTTPRRCACTAGYHW----SQDCECCRRNTECAPGLGAQHPLQLN 146
           +CD    L A    + T    C C+ G+         C  CR     +PG   Q     +
Sbjct: 98  MCDPAMGLRASRNCSRTENAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTES 157

Query: 147 KDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFL 178
           +DT+C+ C  G FS    + ++C+  T C++L
Sbjct: 158 QDTLCQNCPPGTFSPN-GTLEECQHQTKCSWL 188


>gi|7657039 tumor necrosis factor receptor superfamily, member 21
           precursor [Homo sapiens]
          Length = 655

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 54/175 (30%), Positives = 75/175 (42%), Gaps = 12/175 (6%)

Query: 40  YEHLGRC------CNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCL-LHKVC 92
           Y H+ R       C+KC  G Y+S  CT TS  VC  C    +    N  +KC    + C
Sbjct: 54  YRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPC 113

Query: 93  DTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCK 152
                ++  +   + T R C C  G   S     C  +T C  G G +      +D  CK
Sbjct: 114 PW--PMIEKLPCAALTDRECTCPPGMFQSN--ATCAPHTVCPVGWGVRKKGTETEDVRCK 169

Query: 153 PCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSSLPARKPPNEP 207
            C  G FSD  SS  KC+ +T+C      V   GT+++D VC  +LP+      P
Sbjct: 170 QCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVC-GTLPSFSSSTSP 223


>gi|5730095 tumor necrosis factor receptor superfamily, member 9
           precursor [Homo sapiens]
          Length = 255

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 56/204 (27%), Positives = 83/204 (40%), Gaps = 45/204 (22%)

Query: 47  CNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAG-- 104
           C+ C  G +    C    + +C PC P+ +  +  +       + CD  +    V     
Sbjct: 28  CSNCPAGTF----CDNNRNQICSPCPPNSFSSAGGQ-------RTCDICRQCKGVFRTRK 76

Query: 105 --NSTTPRRCACTAGYHW-SQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSD 161
             +ST+   C CT G+H     C  C +  +C  G       +L K   CK C  G F+D
Sbjct: 77  ECSSTSNAECDCTPGFHCLGAGCSMCEQ--DCKQGQ------ELTKKG-CKDCCFGTFND 127

Query: 162 AFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSS--------------LPARKPPNEP 207
                  CRPWTNC+  GK V  +GT++ D VC  S               PAR+P + P
Sbjct: 128 --QKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSP 185

Query: 208 HVYLPGLIILLLFASVALVAAIIF 231
            +    +   L   S AL+  + F
Sbjct: 186 QI----ISFFLALTSTALLFLLFF 205


>gi|4505393 nerve growth factor receptor precursor [Homo sapiens]
          Length = 427

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 54/189 (28%), Positives = 77/189 (40%), Gaps = 18/189 (9%)

Query: 20  LLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDS 79
           LL  L V+L  A        Y H G CC  C  G+ ++  C   + +VC PC     LDS
Sbjct: 17  LLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGA-NQTVCEPC-----LDS 70

Query: 80  WNEEDKCLLHKVCDTGKALVAVVAGNSTTPRR----CACTAGYHWSQD---CECCRRNTE 132
               D     + C      V + + ++         C C  GY+  +    CE CR    
Sbjct: 71  VTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACR---V 127

Query: 133 CAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDA 192
           C  G G     Q  ++TVC+ C  G +SD  +  D C P T C    +++    T  +DA
Sbjct: 128 CEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQL-RECTRWADA 186

Query: 193 VCSSSLPAR 201
            C   +P R
Sbjct: 187 EC-EEIPGR 194


>gi|23200023 tumor necrosis factor receptor superfamily, member 25
           isoform 3 precursor [Homo sapiens]
          Length = 380

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 51/173 (29%), Positives = 74/173 (42%), Gaps = 17/173 (9%)

Query: 1   MAPRARRRRPLFALLLLCALLARLQVALQIAP-PCTSEKHYEHLGRCCNKCEPGKYMSSK 59
           M  R R    + A LLL  L AR Q   +     C  + H +    CC  C  G Y+ + 
Sbjct: 1   MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAP 60

Query: 60  CT-TTSDSVCLPCGPDEYLDSW--NEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTA 116
           CT    +S CL C  D +L +W  +   +C   + CD   + VA+   ++    RC C  
Sbjct: 61  CTEPCGNSTCLVCPQDTFL-AWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKP 119

Query: 117 GYHWSQDCECCRRNTE----CAPGL--GAQHP----LQLNKDTVCKPCLAGYF 159
           G  W  +C+  +  +     C P L  GA H     L   +DT C  CL G++
Sbjct: 120 G--WFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFY 170


>gi|23200021 tumor necrosis factor receptor superfamily, member 25
           isoform 1 precursor [Homo sapiens]
          Length = 426

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 51/173 (29%), Positives = 74/173 (42%), Gaps = 17/173 (9%)

Query: 1   MAPRARRRRPLFALLLLCALLARLQVALQIAP-PCTSEKHYEHLGRCCNKCEPGKYMSSK 59
           M  R R    + A LLL  L AR Q   +     C  + H +    CC  C  G Y+ + 
Sbjct: 1   MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAP 60

Query: 60  CT-TTSDSVCLPCGPDEYLDSW--NEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTA 116
           CT    +S CL C  D +L +W  +   +C   + CD   + VA+   ++    RC C  
Sbjct: 61  CTEPCGNSTCLVCPQDTFL-AWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKP 119

Query: 117 GYHWSQDCECCRRNTE----CAPGL--GAQHP----LQLNKDTVCKPCLAGYF 159
           G  W  +C+  +  +     C P L  GA H     L   +DT C  CL G++
Sbjct: 120 G--WFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFY 170


>gi|89142745 tumor necrosis factor receptor superfamily, member 25
           isoform 12 precursor [Homo sapiens]
          Length = 181

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 51/173 (29%), Positives = 74/173 (42%), Gaps = 17/173 (9%)

Query: 1   MAPRARRRRPLFALLLLCALLARLQVALQIAP-PCTSEKHYEHLGRCCNKCEPGKYMSSK 59
           M  R R    + A LLL  L AR Q   +     C  + H +    CC  C  G Y+ + 
Sbjct: 1   MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAP 60

Query: 60  CT-TTSDSVCLPCGPDEYLDSW--NEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTA 116
           CT    +S CL C  D +L +W  +   +C   + CD   + VA+   ++    RC C  
Sbjct: 61  CTEPCGNSTCLVCPQDTFL-AWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKP 119

Query: 117 GYHWSQDCECCRRNTE----CAPGL--GAQHP----LQLNKDTVCKPCLAGYF 159
           G  W  +C+  +  +     C P L  GA H     L   +DT C  CL G++
Sbjct: 120 G--WFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFY 170


>gi|4507569 tumor necrosis factor receptor superfamily, member 25
           isoform 2 precursor [Homo sapiens]
          Length = 417

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 51/173 (29%), Positives = 74/173 (42%), Gaps = 17/173 (9%)

Query: 1   MAPRARRRRPLFALLLLCALLARLQVALQIAP-PCTSEKHYEHLGRCCNKCEPGKYMSSK 59
           M  R R    + A LLL  L AR Q   +     C  + H +    CC  C  G Y+ + 
Sbjct: 1   MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAP 60

Query: 60  CT-TTSDSVCLPCGPDEYLDSW--NEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTA 116
           CT    +S CL C  D +L +W  +   +C   + CD   + VA+   ++    RC C  
Sbjct: 61  CTEPCGNSTCLVCPQDTFL-AWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKP 119

Query: 117 GYHWSQDCECCRRNTE----CAPGL--GAQHP----LQLNKDTVCKPCLAGYF 159
           G  W  +C+  +  +     C P L  GA H     L   +DT C  CL G++
Sbjct: 120 G--WFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFY 170


>gi|68348711 tumor necrosis factor receptor superfamily, member 8
           isoform 1 precursor [Homo sapiens]
          Length = 595

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 38/130 (29%), Positives = 53/130 (40%), Gaps = 9/130 (6%)

Query: 45  RCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAG 104
           RCC +C  G + + +C          C PD YLD   E D+C     C     LV     
Sbjct: 43  RCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLD---EADRCTACVTCSRDD-LVEKTPC 98

Query: 105 NSTTPRRCACTAGYHWS----QDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFS 160
              + R C C  G   S      C  C  ++ C  G+  + P    K+TVC+P   G  S
Sbjct: 99  AWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPG-VS 157

Query: 161 DAFSSTDKCR 170
            A +S + C+
Sbjct: 158 PACASPENCK 167


>gi|23510423 tumor necrosis factor receptor superfamily, member 6
           isoform 3 precursor [Homo sapiens]
          Length = 220

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 36/115 (31%), Positives = 51/115 (44%), Gaps = 6/115 (5%)

Query: 42  HLGRCCNK-CEPGKYMSSKCTTTSDSV-CLPCGPD-EYLDSWNEEDKCLLHKVCDTGKAL 98
           H G+ C+K C PG+  +  CT   D   C+PC    EY D  +   KC   ++CD G  L
Sbjct: 54  HDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGL 113

Query: 99  VAVVAGNSTTPRRCACTAGYHW-SQDCECCRRNTECAPGLGAQHPLQLNKDTVCK 152
              +    T   +C C   +   S  CE C   T+C  G+  +    L  +T CK
Sbjct: 114 EVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKE--CTLTSNTKCK 166


>gi|23510421 tumor necrosis factor receptor superfamily, member 6
           isoform 2 precursor [Homo sapiens]
          Length = 314

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 36/115 (31%), Positives = 51/115 (44%), Gaps = 6/115 (5%)

Query: 42  HLGRCCNK-CEPGKYMSSKCTTTSDSV-CLPCGPD-EYLDSWNEEDKCLLHKVCDTGKAL 98
           H G+ C+K C PG+  +  CT   D   C+PC    EY D  +   KC   ++CD G  L
Sbjct: 54  HDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGL 113

Query: 99  VAVVAGNSTTPRRCACTAGYHW-SQDCECCRRNTECAPGLGAQHPLQLNKDTVCK 152
              +    T   +C C   +   S  CE C   T+C  G+  +    L  +T CK
Sbjct: 114 EVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKE--CTLTSNTKCK 166


>gi|4507583 tumor necrosis factor receptor superfamily, member 6
           isoform 1 precursor [Homo sapiens]
          Length = 335

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 36/115 (31%), Positives = 51/115 (44%), Gaps = 6/115 (5%)

Query: 42  HLGRCCNK-CEPGKYMSSKCTTTSDSV-CLPCGPD-EYLDSWNEEDKCLLHKVCDTGKAL 98
           H G+ C+K C PG+  +  CT   D   C+PC    EY D  +   KC   ++CD G  L
Sbjct: 54  HDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGL 113

Query: 99  VAVVAGNSTTPRRCACTAGYHW-SQDCECCRRNTECAPGLGAQHPLQLNKDTVCK 152
              +    T   +C C   +   S  CE C   T+C  G+  +    L  +T CK
Sbjct: 114 EVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKE--CTLTSNTKCK 166


>gi|4759246 tumor necrosis factor receptor superfamily, member 18
           isoform 1 precursor [Homo sapiens]
          Length = 241

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 36/123 (29%), Positives = 53/123 (43%), Gaps = 8/123 (6%)

Query: 112 CACTAG-YHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCR 170
           C C    +H    C    R+  C PG G Q   + +    C  C +G FS        C+
Sbjct: 72  CMCVQPEFHCGDPCCTTCRHHPCPPGQGVQSQGKFSFGFQCIDCASGTFSGGHEG--HCK 129

Query: 171 PWTNCTFLGKRVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAII 230
           PWT+CT  G      G +  +AVC        PP EP  +L  +++L + A V L+ +  
Sbjct: 130 PWTDCTQFGFLTVFPGNKTHNAVCVPG----SPPAEPLGWLT-VVLLAVAACVLLLTSAQ 184

Query: 231 FGV 233
            G+
Sbjct: 185 LGL 187


>gi|23238197 tumor necrosis factor receptor superfamily, member 18
           isoform 3 precursor [Homo sapiens]
          Length = 234

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 36/123 (29%), Positives = 53/123 (43%), Gaps = 8/123 (6%)

Query: 112 CACTAG-YHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCR 170
           C C    +H    C    R+  C PG G Q   + +    C  C +G FS        C+
Sbjct: 72  CMCVQPEFHCGDPCCTTCRHHPCPPGQGVQSQGKFSFGFQCIDCASGTFSGGHEG--HCK 129

Query: 171 PWTNCTFLGKRVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAII 230
           PWT+CT  G      G +  +AVC        PP EP  +L  +++L + A V L+ +  
Sbjct: 130 PWTDCTQFGFLTVFPGNKTHNAVCVPG----SPPAEPLGWLT-VVLLAVAACVLLLTSAQ 184

Query: 231 FGV 233
            G+
Sbjct: 185 LGL 187


>gi|4507575 tumor necrosis factor receptor 1 precursor [Homo
           sapiens]
          Length = 455

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 56/233 (24%), Positives = 92/233 (39%), Gaps = 36/233 (15%)

Query: 39  HYEHLGRCCNKCEPGKYMSSKCT-TTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKA 97
           H ++   CC KC  G Y+ + C     D+ C  C    +  S N    CL    C     
Sbjct: 51  HPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMG 110

Query: 98  LVAVVAGNSTTPRRCACTAG---YHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPC 154
            V + +        C C      ++WS++   C   + C  G       Q  ++TVC  C
Sbjct: 111 QVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGT-VHLSCQEKQNTVC-TC 168

Query: 155 LAGYF--SDAFSSTDKCRPWTNCTFLG-KRVEH-HGTEKSDAVCSSSLPARKPPNEPHVY 210
            AG+F   +   S   C+    CT L   ++E+  GTE S                  V 
Sbjct: 169 HAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTT---------------VL 213

Query: 211 LPGLIILLLFASVALVAAIIFGVCYR-KKGKALTANLWHWINEACGRLSGDKE 262
           LP    L++F  + L++ +  G+ YR ++ K+   ++       CG+ + +KE
Sbjct: 214 LP----LVIFFGLCLLSLLFIGLMYRYQRWKSKLYSI------VCGKSTPEKE 256


>gi|4507587 tumor necrosis factor receptor superfamily, member 7
           precursor [Homo sapiens]
          Length = 260

 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 36/122 (29%), Positives = 52/122 (42%), Gaps = 11/122 (9%)

Query: 17  LCALLARLQVALQIAPPCTSEKHYEHLGR-CCNKCEPGKYMSSKCTTTSDSV-CLPCGPD 74
           LC L   + ++   AP    E+HY   G+ CC  CEPG ++   C     +  C PC P 
Sbjct: 9   LCVLGTLVGLSATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPG 68

Query: 75  -EYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTEC 133
             +    +    C   + C++G   + V     T    CAC  G+   +D EC    TEC
Sbjct: 69  VSFSPDHHTRPHCESCRHCNSG---LLVRNCTITANAECACRNGWQ-CRDKEC----TEC 120

Query: 134 AP 135
            P
Sbjct: 121 DP 122


>gi|7710121 engrailed homeobox 2 [Homo sapiens]
          Length = 333

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 44/136 (32%), Positives = 49/136 (36%), Gaps = 21/136 (15%)

Query: 458 EPLVGSPKRGPL--PQCAYGMGLPPEEEASRTEARDQPEDGADGRLPSSARAGAGSGSSP 515
           E L+GS  R P   P CA G G P     S     D P DG  G    S   GA  G  P
Sbjct: 119 EQLLGSGSREPRQNPPCAPGAGGPLPAAGS-----DSPGDGEGGSKTLSLHGGAKKGGDP 173

Query: 516 GGQSPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETL 575
           GG    S    G                GD+ V   S +SQ GA   A+PM  P      
Sbjct: 174 GGPLDGSLKARGLGG-------------GDLSVSSDSDSSQAGANLGAQPMLWPAW-VYC 219

Query: 576 ARRDSFAGNGPRFPDP 591
            R      +GPR   P
Sbjct: 220 TRYSDRPSSGPRSRKP 235


>gi|4557733 latent transforming growth factor beta binding protein 2
            [Homo sapiens]
          Length = 1821

 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 41/144 (28%), Positives = 55/144 (38%), Gaps = 16/144 (11%)

Query: 44   GRC--CNKCE-PGKYMSSKCTTTSDS-VCLPC--GPDEYLDSWNEEDKCLLHKVCDTGKA 97
            G C   N+C  PG     +C  +  S  CL C  G      S  + ++CL   VC  GK 
Sbjct: 966  GHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKC 1025

Query: 98   LVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKD--TVCKPCL 155
                   N     RC+C  GY  + D + C+   ECA        L LN +    C  C 
Sbjct: 1026 T------NLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACE 1079

Query: 156  AGYFSDAFSSTDKCRPWTNCTFLG 179
             GY+ +   +   C     C F G
Sbjct: 1080 NGYWVNEDGTA--CEDLDECAFPG 1101



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 13/33 (39%), Positives = 16/33 (48%)

Query: 95   GKALVAVVAGNSTTPRRCACTAGYHWSQDCECC 127
            G A  + V G +TT   C CT G  W   C+ C
Sbjct: 1419 GHAPCSSVLGRNTTQAECCCTQGASWGDACDLC 1451



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 27/114 (23%), Positives = 41/114 (35%), Gaps = 22/114 (19%)

Query: 34   CTSEKHYEHLGRCC---NKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCL--- 87
            C    HY+   + C   ++C+     + +C  T  S    C P   LD    + +C+   
Sbjct: 1513 CNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLDL--SQQRCMNST 1570

Query: 88   ----------LHK-VC---DTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECC 127
                      +H  +C    T       + G+ TT   C C  G  WSQ C  C
Sbjct: 1571 SSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALC 1624


>gi|11140823 X-linked ectodysplasin receptor [Homo sapiens]
          Length = 297

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/85 (28%), Positives = 35/85 (41%), Gaps = 8/85 (9%)

Query: 34  CTSEKHYEHLGRC--CNKCEPGKYMSSKCT--TTSDSVCLPCGPDEYLDSWNEEDKCLLH 89
           C   ++++  GRC  C +C PG+ +S  C      D+ C  C P  Y  SW    +C   
Sbjct: 3   CQENEYWDQWGRCVTCQRCGPGQELSKDCGYGEGGDAYCTACPPRRYKSSWGHH-RC--- 58

Query: 90  KVCDTGKALVAVVAGNSTTPRRCAC 114
           + C T   +  V   N T      C
Sbjct: 59  QSCITCAVINRVQKVNCTATSNAVC 83


>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
          Length = 2161

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 41/174 (23%), Positives = 64/174 (36%), Gaps = 21/174 (12%)

Query: 443  ADVCTGCRNPPGEDCE--PLVGSPKRGPLPQCAYGMGLPPEEEASRTEARDQPEDGADGR 500
            A    G  +PPG      P   +P+ GP P      G+   EE     + D P +     
Sbjct: 1638 ASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGI---EEVDSRSSSDHPLETISSA 1694

Query: 501  LPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGAA 560
               S+ +  G GS+ GG    +G          ++SG  +    D  V Y+   +  G++
Sbjct: 1695 STLSSLSAEGGGSAGGGGGAGAG----------VASGPELL---DTYVAYLDGQAFGGSS 1741

Query: 561  AAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLREPEKASRPVQEQGGA 614
                P    +   +  R  +   +G   P P G   GLR+P   + P     GA
Sbjct: 1742 TPGPPYPPQLMTPSKLRGRALGASGGLRPGPSG---GLRDPVTPTSPTVSVTGA 1792



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 40/157 (25%), Positives = 59/157 (37%), Gaps = 24/157 (15%)

Query: 450 RNPPGEDCEPLVGSPK-----RGPLPQCAYGMGLPPEEEASRTEARDQPEDGADGRLPSS 504
           RN   +D  P   SPK     RGP      G+ +PP    + ++      D      P  
Sbjct: 400 RNHREQDVVPFQESPKYAARRRGPP---GTGLTVPPALLRANSDTSMALPDWMVFSAP-- 454

Query: 505 ARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGAAAAAE 564
              GA S  +PG  S + G    ++ +T +SSG +            S +S  GA A + 
Sbjct: 455 ---GAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLR-----------SASSPRGARARSP 500

Query: 565 PMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLREP 601
             GR  ++     R   + +G     P GG  G   P
Sbjct: 501 SRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGP 537


>gi|23238194 tumor necrosis factor receptor superfamily, member 18
           isoform 2 precursor [Homo sapiens]
          Length = 255

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 21/71 (29%), Positives = 30/71 (42%), Gaps = 3/71 (4%)

Query: 112 CACTAG-YHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCR 170
           C C    +H    C    R+  C PG G Q   + +    C  C +G FS        C+
Sbjct: 72  CMCVQPEFHCGDPCCTTCRHHPCPPGQGVQSQGKFSFGFQCIDCASGTFSGGHEG--HCK 129

Query: 171 PWTNCTFLGKR 181
           PWT+C +  +R
Sbjct: 130 PWTDCCWRCRR 140


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,306,933
Number of Sequences: 37866
Number of extensions: 1687704
Number of successful extensions: 7672
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 195
Number of HSP's that attempted gapping in prelim test: 6986
Number of HSP's gapped (non-prelim): 812
length of query: 616
length of database: 18,247,518
effective HSP length: 108
effective length of query: 508
effective length of database: 14,157,990
effective search space: 7192258920
effective search space used: 7192258920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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