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Search of human proteins with 41152101
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41152101 calpain 13 [Homo sapiens]
(669 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41152101 calpain 13 [Homo sapiens] 1375 0.0
gi|223468608 calpain 14 [Homo sapiens] 365 e-101
gi|12408656 calpain 1, large subunit [Homo sapiens] 345 6e-95
gi|215490104 calpain 11 [Homo sapiens] 340 2e-93
gi|221554549 calpain 8 [Homo sapiens] 331 2e-90
gi|27765074 calpain 3 isoform c [Homo sapiens] 330 3e-90
gi|157389005 calpain 2 isoform 1 [Homo sapiens] 311 9e-85
gi|5729758 calpain 9 isoform 1 [Homo sapiens] 309 5e-84
gi|27765072 calpain 3 isoform b [Homo sapiens] 303 4e-82
gi|4557405 calpain 3 isoform a [Homo sapiens] 300 2e-81
gi|47078247 calpain 3 isoform f [Homo sapiens] 284 2e-76
gi|7705383 calpain 9 isoform 2 [Homo sapiens] 276 4e-74
gi|225703100 calpain 2 isoform 2 [Homo sapiens] 275 1e-73
gi|38707981 calpain 12 [Homo sapiens] 268 1e-71
gi|37577157 calpain 5 [Homo sapiens] 201 2e-51
gi|13186316 calpain 6 [Homo sapiens] 177 4e-44
gi|13186302 calpain 10 isoform a [Homo sapiens] 155 1e-37
gi|89353291 calpain 10 isoform c [Homo sapiens] 148 2e-35
gi|5032105 small optic lobes [Homo sapiens] 120 5e-27
gi|4502565 calpain, small subunit 1 [Homo sapiens] 102 1e-21
gi|51599151 calpain, small subunit 1 [Homo sapiens] 102 1e-21
gi|7656959 calpain 7 [Homo sapiens] 99 1e-20
gi|27765076 calpain 3 isoform d [Homo sapiens] 96 1e-19
gi|27765080 calpain 3 isoform e [Homo sapiens] 91 4e-18
gi|27765078 calpain 3 isoform e [Homo sapiens] 91 4e-18
gi|14161692 calpain small subunit 2 [Homo sapiens] 87 4e-17
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap... 56 9e-08
gi|38679884 sorcin isoform b [Homo sapiens] 54 6e-07
gi|4507207 sorcin isoform a [Homo sapiens] 54 6e-07
gi|13186314 calpain 10 isoform g [Homo sapiens] 48 3e-05
>gi|41152101 calpain 13 [Homo sapiens]
Length = 669
Score = 1375 bits (3560), Expect = 0.0
Identities = 669/669 (100%), Positives = 669/669 (100%)
Query: 1 MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNV 60
MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNV
Sbjct: 1 MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNV 60
Query: 61 IWKRPQDLPGGPPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSH 120
IWKRPQDLPGGPPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSH
Sbjct: 61 IWKRPQDLPGGPPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSH 120
Query: 121 QYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSY 180
QYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSY
Sbjct: 121 QYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSY 180
Query: 181 SDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQA 240
SDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQA
Sbjct: 181 SDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQA 240
Query: 241 MENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPR 300
MENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPR
Sbjct: 241 MENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPR 300
Query: 301 KSQLHKKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGN 360
KSQLHKKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGN
Sbjct: 301 KSQLHKKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGN 360
Query: 361 TAGGPRNDAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFRE 420
TAGGPRNDAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFRE
Sbjct: 361 TAGGPRNDAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFRE 420
Query: 421 KFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQTRRKSAEFLLRIFLKMPDS 480
KFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQTRRKSAEFLLRIFLKMPDS
Sbjct: 421 KFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQTRRKSAEFLLRIFLKMPDS 480
Query: 481 DRHLSSHFNLRMKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSL 540
DRHLSSHFNLRMKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSL
Sbjct: 481 DRHLSSHFNLRMKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSL 540
Query: 541 DECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSPGVLLSSDLWKAIENTD 600
DECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSPGVLLSSDLWKAIENTD
Sbjct: 541 DECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSPGVLLSSDLWKAIENTD 600
Query: 601 FLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLYLTEM 660
FLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLYLTEM
Sbjct: 601 FLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLYLTEM 660
Query: 661 EWMSLVMYN 669
EWMSLVMYN
Sbjct: 661 EWMSLVMYN 669
>gi|223468608 calpain 14 [Homo sapiens]
Length = 684
Score = 365 bits (937), Expect = e-101
Identities = 245/675 (36%), Positives = 353/675 (52%), Gaps = 42/675 (6%)
Query: 19 QDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILD 78
QDF L CL G F+D +FPA SSIG L +K + WKRP +L P F
Sbjct: 28 QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNP-QFYFA 86
Query: 79 DISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFWQCGQWV 137
R D+ QG DCWFLAAL +L + +++ + QSF+ +YAGIFRF FW G WV
Sbjct: 87 KAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWV 146
Query: 138 EVVIDDRLPV-QGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLT 196
VVIDDRLPV + + +FV ++N FW LLEKAYAKL GSY DL G + +ALVD T
Sbjct: 147 PVVIDDRLPVNEAGQLVFVSSTYKNL-FWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205
Query: 197 GGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAYTVTGA 256
GGV I+L + +L + AT +LI C T SG + +ENGLV HAYT+TG
Sbjct: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSGE----KILENGLVEGHAYTLTGI 261
Query: 257 EQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKREDGEFWMS 316
++ + E ++ L NPWG + EW+G WSD S +WE K L +K DGEFWM+
Sbjct: 262 RKVTCKHRPEYLVKLRNPWG--KVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMT 319
Query: 317 CQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPR--------ND 368
QDF+ F+ + IC P L + W+ M + +TAGG R +
Sbjct: 320 LQDFKTHFVLLVICKLTPGLL--SQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKN 377
Query: 369 AQFNFSVQEPMEGTNVV----VCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFRE---K 421
QF SV P EG + V V++ P + + K L L ++ + +
Sbjct: 378 PQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRH-RCRKRKPLLAIGFYLYRMNKYHDDQRR 436
Query: 422 FPPVFFSSFRNTVQSSNNKF--RRNFTMTYHLSPGNYVVV---AQTRRKSAEFLLRIFLK 476
PP FF RNT S ++F + + L PG Y++V + +KS EF+LR+F +
Sbjct: 437 LPPEFFQ--RNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKS-EFVLRVFSR 493
Query: 477 MPDSDRHLSSHFNLRMKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQELLT--GPP 534
S+ + K ++ Q F ++ ++ +I+A QLQ LLNQ + G
Sbjct: 494 KHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQNLLNQMTWSSLGSR 553
Query: 535 GDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSPGVLLSSDLWK 594
FSL+ C+ ++AL++L +G + +EF LWK+L Q VF K G L L
Sbjct: 554 QPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRGSGYLNWEQLHA 613
Query: 595 AIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKG 654
A+ GI +S ++ L+ +RY ++ F S + ++R+E M F+NL++DGKG
Sbjct: 614 AMREA----GIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKG 669
Query: 655 LYLTEMEWMSLVMYN 669
+YL + EWM + +Y+
Sbjct: 670 IYLQKPEWMMMALYS 684
>gi|12408656 calpain 1, large subunit [Homo sapiens]
Length = 714
Score = 345 bits (886), Expect = 6e-95
Identities = 239/693 (34%), Positives = 343/693 (49%), Gaps = 52/693 (7%)
Query: 14 IKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLL--QEKRLSNVIWKRPQDLPGG 71
IK+ QD+ LR CL G F+DE FP S+G K L + + WKRP +L
Sbjct: 35 IKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSN 94
Query: 72 PPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRF 130
P FI+D +R DI QG DCW LAA+ SLT N +++ QSF + YAGIF F+
Sbjct: 95 P-QFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQL 153
Query: 131 WQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLED 190
WQ G+WV+VV+DD LP++ K +FV N EFW LLEKAYAK+ GSY L G +
Sbjct: 154 WQFGEWVDVVVDDLLPIKDGKLVFVHSAEGN-EFWSALLEKAYAKVNGSYEALSGGSTSE 212
Query: 191 ALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATP-SGPTDTAQAMENGLVSLH 249
D TGGV L +P DL + + A + GSL+ C+ S D LV H
Sbjct: 213 GFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGH 272
Query: 250 AYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRE 309
AY+VTGA+Q+ YR +I + NPWG E EW G WSD S EW + QL K E
Sbjct: 273 AYSVTGAKQVNYRGQVVSLIRMRNPWG--EVEWTGAWSDSSSEWNNVDPYERDQLRVKME 330
Query: 310 DGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-- 367
DGEFWMS +DF ++F + IC+ P L T+ + W+ ++ G+TAGG RN
Sbjct: 331 DGEFWMSFRDFMREFTRLEICNLTPDAL-KSRTIRK-WNTTLYEGTWRRGSTAGGCRNYP 388
Query: 368 -----DAQFNFSVQEPME----GTNVVVCVTVAVTPSNLKAEDAKFPLDFQVI------- 411
+ QF + E + G C V + + +F D + I
Sbjct: 389 ATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEV 448
Query: 412 ---LAGSQRFREKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKS 466
L G K FF + + +S R + + L PG YVVV T K
Sbjct: 449 PPELVGQPAVHLKRD--FFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKE 506
Query: 467 AEFLLRIFLKMPDSDRHLSSHF--NLRMKGSPSEHGSQQ---SIFNRYAQQRLDIDATQL 521
+F+LR F + L NL + SE + ++F + A + ++I +L
Sbjct: 507 GDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKEL 566
Query: 522 QGLLNQELLTGPPGDM----FSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVF 577
+ +LN+ + D+ FSL+ CRS+V LM+ NG+L EF LW R+ +Y +F
Sbjct: 567 RTILNR--IISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIF 624
Query: 578 QKVQ-TSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLM 636
+K G + + ++ AIE+ G ++++L L+ RYS+ V F + VC L+
Sbjct: 625 RKFDLDKSGSMSAYEMRMAIESA----GFKLNKKLYELIITRYSEPDLAVDFDNFVCCLV 680
Query: 637 RLEAMAKTFRNLSKDGKGLYLTEM-EWMSLVMY 668
RLE M + F+ L D G+ ++ +W+ L M+
Sbjct: 681 RLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMF 713
>gi|215490104 calpain 11 [Homo sapiens]
Length = 739
Score = 340 bits (872), Expect = 2e-93
Identities = 238/691 (34%), Positives = 352/691 (50%), Gaps = 51/691 (7%)
Query: 16 FKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLL--QEKRLSNVIWKRPQDLPGGPP 73
F +Q F LR CL G F+D FPA SS+G K L K + N+ W+RP+D+ P
Sbjct: 61 FGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPL 120
Query: 74 HFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL-MVQSFSHQYAGIFRFRFWQ 132
FI+D IS DI QG DCW LAA+GSLT P+ +++ QSF YAGIF F+ WQ
Sbjct: 121 -FIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQ 179
Query: 133 CGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDAL 192
GQWV VV+DDRLP + DK +FV ++ EFW LLEKAYAKL GSY L G + L
Sbjct: 180 FGQWVNVVVDDRLPTKNDKLVFVHSTERS-EFWSALLEKAYAKLSGSYEALSGGSTMEGL 238
Query: 193 VDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAM-ENGLVSLHAY 251
D TGGV + L P +L++ ++ A + SL+ C+ ++M + LV HAY
Sbjct: 239 EDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAY 298
Query: 252 TVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKREDG 311
+VTG + + YR E +I + NPWG EW G WSD ++EWEE + QL K EDG
Sbjct: 299 SVTGLQDVHYRGKMETLIRVRNPWG--RIEWNGAWSDSAREWEEVASDIQMQLLHKTEDG 356
Query: 312 EFWMSCQDFQQKFIAMFICSEIPITL--DHGNTLHEGWSQIMFRKQVILGNTAGGPRN-- 367
EFWMS QDF F + IC+ P TL D+ + H + + +R+ G++AGG RN
Sbjct: 357 EFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRR----GSSAGGCRNHP 412
Query: 368 -----DAQFNFSV------QEPMEGTNVVVCV-TVAVTPSN---LKAEDAKFPLDFQVIL 412
+ QF S+ ++ EG NVVVC VA+ N + + A+ V+
Sbjct: 413 GTFWTNPQFKISLPEGDDPEDDAEG-NVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLY 471
Query: 413 AGSQRFRE----KFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKS 466
A + F+ FF+ +++ S R + L PG Y+++ T +
Sbjct: 472 AVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRD 531
Query: 467 AEFLLRIFLKMPDSDRHLS--SHFNLRMKGSPSEHGSQQS---IFNRYAQQRLDIDATQL 521
A+FLLR+F + L ++ + SE Q +F A + +I +L
Sbjct: 532 ADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYEL 591
Query: 522 QGLLNQELLTGPPGDM--FSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQK 579
Q LLN+ + F LD CR ++ LM+ +G+L EF LWK+L + +F++
Sbjct: 592 QRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRE 651
Query: 580 V-QTSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRL 638
Q G L S ++ IE GI ++ +++ ++ RY+D + F S + +RL
Sbjct: 652 CDQDHSGTLNSYEMRLVIEKA----GIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRL 707
Query: 639 EAMAKTFRNLSKDGKG-LYLTEMEWMSLVMY 668
+ M F + G + L+ +W+ + M+
Sbjct: 708 KTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
>gi|221554549 calpain 8 [Homo sapiens]
Length = 703
Score = 331 bits (848), Expect = 2e-90
Identities = 232/695 (33%), Positives = 346/695 (49%), Gaps = 58/695 (8%)
Query: 14 IKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQ--EKRLSNVIWKRPQDLPGG 71
+K+ QDF TLR CL G FKD FPA S++G K L + +IWKRP +L
Sbjct: 25 LKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPS 84
Query: 72 PPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL-MVQSFSHQYAGIFRFRF 130
P FI+ +R DI QGG DCW LAA+ SLT N + +++ Q F YAGIF F+F
Sbjct: 85 P-QFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQF 143
Query: 131 WQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLED 190
WQ G+WVEVVIDDRLP + + LF+ Q EFW LLEKAYAKL G Y L G +
Sbjct: 144 WQYGEWVEVVIDDRLPTKNGQLLFLHSE-QGNEFWSALLEKAYAKLNGCYEALAGGSTVE 202
Query: 191 ALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENG-LVSLH 249
D TGG+ L P +L + ++ A AGSL+ C+ A+A+ + LV H
Sbjct: 203 GFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSH 262
Query: 250 AYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRE 309
AY+VTG E++ ++ E++I L NPWG E EW G WSD + EW RK +L KK E
Sbjct: 263 AYSVTGVEEVNFQGHPEKLIRLRNPWG--EVEWSGAWSDDAPEWNHIDPRRKEELDKKVE 320
Query: 310 DGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-- 367
DGEFWMS DF ++F + IC+ P +L +H+ W+ ++F G+TAGG +N
Sbjct: 321 DGEFWMSLSDFVRQFSRLEICNLSPDSLS-SEEVHK-WNLVLFNGHWTRGSTAGGCQNYP 378
Query: 368 -----DAQFNF---SVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFP------------LD 407
+ QF V E E + C TV + L ++ ++
Sbjct: 379 ATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLL---GLMQKNRRWRKRIGQGMLSIGYAV 435
Query: 408 FQVILAGSQRFREKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQTRR--K 465
+QV FF +++ + ++S R + L PG Y+VV T K
Sbjct: 436 YQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFK 495
Query: 466 SAEFLLRIFLKMPDSDRHLSSHFNLRMKGSPSE-HGSQ--------QSIFNRYAQQRLDI 516
EF LR+F + + + G+P E H S+ + +F + A + +I
Sbjct: 496 DGEFCLRVFSEKKAQALEIGD----VVAGNPYEPHPSEVDQEDDQFRRLFEKLAGKDSEI 551
Query: 517 DATQLQGLLNQEL--LTGPPGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQ 574
A L+ LLN+ T D F+++ CR +++L++ G L EF LW ++ Y
Sbjct: 552 TANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYL 611
Query: 575 HVFQKVQ-TSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVC 633
++ + G + + ++ A+ G ++ ++ + LRY+ S ++F S V
Sbjct: 612 EIYWETDYNHSGTIDAHEMRTALRKA----GFTLNSQVQQTIALRYACSKLGINFDSFVA 667
Query: 634 FLMRLEAMAKTFRNLSKDGKGL-YLTEMEWMSLVM 667
++RLE + K F L +D G+ L+ EW+ V+
Sbjct: 668 CMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCCVL 702
>gi|27765074 calpain 3 isoform c [Homo sapiens]
Length = 729
Score = 330 bits (846), Expect = 3e-90
Identities = 217/691 (31%), Positives = 348/691 (50%), Gaps = 50/691 (7%)
Query: 13 IIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGP 72
II K++ F L CL + D FP ++S+ +K +WKRP ++ P
Sbjct: 53 IIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSL---FYSQKFPIQFVWKRPPEICENP 109
Query: 73 PHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFW 131
FI+D +R DI QG DCWFLAA+ LT N +++ QSF YAGIF F+FW
Sbjct: 110 -RFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFW 168
Query: 132 QCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDA 191
+ G+WV+VVIDD LP ++ +F + H+N EFW LLEKAYAKL GSY L G +A
Sbjct: 169 RYGEWVDVVIDDCLPTYNNQLVFTKSNHRN-EFWSALLEKAYAKLHGSYEALKGGNTTEA 227
Query: 192 LVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPS-GPTDTAQAMENGLVSLHA 250
+ D TGGV + +P D+ K +K A + GSL+ C+ + P M GLV HA
Sbjct: 228 MEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHA 287
Query: 251 YTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQL-HKKRE 309
Y+VTG +++ ++ +++ L NP WG+ EW G WSD ++W K++L H+ E
Sbjct: 288 YSVTGLDEVPFKGEKVKLVRLRNP--WGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTE 345
Query: 310 DGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-- 367
DGEFWMS +DF F + IC+ L + W+ + + + G +AGG RN
Sbjct: 346 DGEFWMSYEDFIYHFTKLEICNLTADALQSDKL--QTWTVSVNEGRWVRGCSAGGCRNFP 403
Query: 368 -----DAQFNFSVQEPME--GTNVVVCVTVAVTPSNLKAEDAK-----FPLDFQVILAGS 415
+ Q+ + E + + V+C + + +D K F + F +
Sbjct: 404 DTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPK 463
Query: 416 QRF--REKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLL 471
+ ++ FF + +S R + + L P YV+V T + EF+L
Sbjct: 464 EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFIL 523
Query: 472 RIFLKMPDSDRHLSSHFN----LRMKGSPSEHGSQQ----SIFNRYAQQRLDIDATQLQG 523
R+F + + + + + + GS + +Q +IF + A ++I A +L+
Sbjct: 524 RVFSEKRNLSEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKK 583
Query: 524 LLNQELLTGPPGDM----FSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQK 579
+LN + D+ F+L+ CRS++ALM+ +G+L+ +EF LW ++ +Q +F+
Sbjct: 584 VLN--TVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKH 641
Query: 580 VQT-SPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRL 638
T G + S ++ A+ + G ++ +L ++T+RY+D + F S +C +RL
Sbjct: 642 YDTDQSGTINSYEMRNAVNDA----GFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRL 697
Query: 639 EAMAKTFRNLSKDGKGLY-LTEMEWMSLVMY 668
E M + F KDG G+ L +EW+ L MY
Sbjct: 698 EGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 728
>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
Length = 700
Score = 311 bits (798), Expect = 9e-85
Identities = 208/681 (30%), Positives = 330/681 (48%), Gaps = 41/681 (6%)
Query: 14 IKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLL--QEKRLSNVIWKRPQDLPGG 71
IK+ +QD+ LR+ CL G F+D +FPA S++G K L + + WKRP ++
Sbjct: 25 IKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICAD 84
Query: 72 PPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRF 130
P FI+ +R DI QG DCW LAA+ SLT N + +++ + QSF YAGIF F+F
Sbjct: 85 P-QFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQF 143
Query: 131 WQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLED 190
WQ G+WVEVV+DDRLP + + LFV + EFW LLEKAYAK+ G Y L G +
Sbjct: 144 WQYGEWVEVVVDDRLPTKDGELLFVHSA-EGSEFWSALLEKAYAKINGCYEALSGGATTE 202
Query: 191 ALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATP-SGPTDTAQAMENGLVSLH 249
D TGG+ L P +L K ++ A + GSL+ C+ + D+ LV H
Sbjct: 203 GFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGH 262
Query: 250 AYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRE 309
AY+VTGAE+++ +++I + NPWG E EW GRW+D W + +L ++ E
Sbjct: 263 AYSVTGAEEVESNGSLQKLIRIRNPWG--EVEWTGRWNDNCPSWNTIDPEERERLTRRHE 320
Query: 310 DGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-- 367
DGEFWMS DF + + + IC+ P TL + ++ W G+TAGG RN
Sbjct: 321 DGEFWMSFSDFLRHYSRLEICNLTPDTLT--SDTYKKWKLTKMDGNWRRGSTAGGCRNYP 378
Query: 368 -----DAQFNFSVQEPMEG--TNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFRE 420
+ Q+ ++E E C + + K D I G E
Sbjct: 379 NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE 438
Query: 421 K--------FPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFL 470
+ FF + R +S R + L PG Y++V T K +F
Sbjct: 439 ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC 498
Query: 471 LRIFLKMPDSDRHLSSHFNLRMK----GSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLN 526
+R+F + + + ++ + +F + A + +I A +LQ +L
Sbjct: 499 IRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR 558
Query: 527 QELLTGP--PGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTS- 583
+ L D FS++ C+ +V +++ +G+L +EF LW ++ YQ +++++
Sbjct: 559 RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR 618
Query: 584 PGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAK 643
G + S ++ KA+E G + +L ++ R++D + F + V L+RLE + K
Sbjct: 619 SGTMNSYEMRKALEEA----GFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFK 674
Query: 644 TFRNLSKDGKG-LYLTEMEWM 663
F+ L + G + L + W+
Sbjct: 675 IFKQLDPENTGTIELDLISWL 695
>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
Length = 690
Score = 309 bits (792), Expect = 5e-84
Identities = 216/684 (31%), Positives = 343/684 (50%), Gaps = 57/684 (8%)
Query: 19 QDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILD 78
Q F +R CL G F+D FPA++SS+ E+ +WKRP ++ P FIL
Sbjct: 27 QSFEQMRQECLQRGTLFEDADFPASNSSL---FYSERPQIPFVWKRPGEIVKNP-EFILG 82
Query: 79 DISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL-MVQSFSHQYAGIFRFRFWQCGQWV 137
+R DI QG DCW LAA+ SLT N + +++ QSF YAGIF F+FWQ +W+
Sbjct: 83 GATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWL 142
Query: 138 EVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTG 197
+VVIDDRLP D+ +F+ N EFW LLEKAYAKL GSY L G +A+ D TG
Sbjct: 143 DVVIDDRLPTFRDRLVFLHSADHN-EFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
Query: 198 GVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMEN------GLVSLHAY 251
GV +P + + ++ A K GSL+ C DT A E+ GL+ HAY
Sbjct: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCF-----IDTRSAAESEARTPFGLIKGHAY 256
Query: 252 TVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQL-HKKRED 310
+VTG +Q+ +R E+I + NP WG+ EW G WSD S EW + +L H +D
Sbjct: 257 SVTGIDQVSFRGQRIELIRIRNP--WGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDD 314
Query: 311 GEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN--- 367
GEFWM+ +DF+ F + IC+ P L+ + +H+ W + + + G+TAGG RN
Sbjct: 315 GEFWMAFKDFKAHFDKVEICNLTPDALEE-DAIHK-WEVTVHQGSWVRGSTAGGCRNFLD 372
Query: 368 ----DAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFR---- 419
+ Q S+ E EG + + K + V+ G +
Sbjct: 373 TFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLK----RFGANVLTIGYAIYECPDK 428
Query: 420 -EKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLLRIFLK 476
E FF + +S R + + L PG Y+++ T + A+F LRIF +
Sbjct: 429 DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSE 488
Query: 477 MPDSDRHLSSHFNLRM----KGSPSEHGSQQ-----SIFNRYAQQRLDIDATQLQGLLNQ 527
R + + ++ + K +P + +++ ++F + A + +++ A +L+ +LN
Sbjct: 489 KKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNA 548
Query: 528 ELLTGP--PGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQT-SP 584
L SL C+++++LM+ NG+L+ +EF W +L + ++F +
Sbjct: 549 VLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKS 608
Query: 585 GVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKT 644
G + + +L A++ G +S LL L+ LRY+D ++ F + L+RLE ++
Sbjct: 609 GTMSTYELRTALK----AAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRV 664
Query: 645 FRNLS-KDGKGLYLTEMEWMSLVM 667
F+ LS K+ + ++L E++ L M
Sbjct: 665 FQALSTKNKEFIHLNINEFIHLTM 688
>gi|27765072 calpain 3 isoform b [Homo sapiens]
Length = 815
Score = 303 bits (775), Expect = 4e-82
Identities = 223/777 (28%), Positives = 354/777 (45%), Gaps = 136/777 (17%)
Query: 13 IIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGP 72
II K++ F L CL + D FP ++S+ +K +WKRP ++ P
Sbjct: 53 IIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSL---FYSQKFPIQFVWKRPPEICENP 109
Query: 73 PHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFW 131
FI+D +R DI QG DCWFLAA+ LT N +++ QSF YAGIF F+FW
Sbjct: 110 -RFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFW 168
Query: 132 QCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDA 191
+ G+WV+VVIDD LP ++ +F + H+N EFW LLEKAYAKL GSY L G +A
Sbjct: 169 RYGEWVDVVIDDCLPTYNNQLVFTKSNHRN-EFWSALLEKAYAKLHGSYEALKGGNTTEA 227
Query: 192 LVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCA-----------TPSG------- 233
+ D TGGV + +P D+ K +K A + GSL+ C+ +PSG
Sbjct: 228 MEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELI 287
Query: 234 -------------------------------PTDTAQAMENGLVSLHAYTVTGAEQIQYR 262
P M GLV HAY+VTG +++ ++
Sbjct: 288 ARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK 347
Query: 263 RGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQL-HKKREDGEFWMSCQDFQ 321
+++ L NP WG+ EW G WSD ++W K++L H+ EDGEFWMS +DF
Sbjct: 348 GEKVKLVRLRNP--WGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFI 405
Query: 322 QKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-------DAQFNFS 374
F + IC+ L + W+ + + + G +AGG RN + Q+
Sbjct: 406 YHFTKLEICNLTADALQSDKL--QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463
Query: 375 VQEPME--GTNVVVCVTVAVTPSNLKAEDAK-----FPLDFQVILAGSQRF--REKFPPV 425
+ E + + V+C + + +D K F + F + + ++
Sbjct: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 523
Query: 426 FFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLLRIFLKMPDSDRH 483
FF + +S R + + L P YV+V T + EF+LR+F + +
Sbjct: 524 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 583
Query: 484 LSSHFNL-----------------------------------RMKGSP----------SE 498
+ + ++ + K SP SE
Sbjct: 584 VENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE 643
Query: 499 HGSQ-QSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDM----FSLDECRSLVALMELK 553
Q ++IF + A ++I A +L+ +LN + D+ F+L+ CRS++ALM+
Sbjct: 644 EQQQFRNIFKQIAGDDMEICADELKKVLN--TVVNKHKDLKTHGFTLESCRSMIALMDTD 701
Query: 554 VNGRLDQEEFARLWKRLVHYQHVFQKVQT-SPGVLLSSDLWKAIENTDFLRGIFISRELL 612
+G+L+ +EF LW ++ +Q +F+ T G + S ++ A+ + G ++ +L
Sbjct: 702 GSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDA----GFHLNNQLY 757
Query: 613 HLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLY-LTEMEWMSLVMY 668
++T+RY+D + F S +C +RLE M + F KDG G+ L +EW+ L MY
Sbjct: 758 DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 814
>gi|4557405 calpain 3 isoform a [Homo sapiens]
Length = 821
Score = 300 bits (769), Expect = 2e-81
Identities = 223/783 (28%), Positives = 354/783 (45%), Gaps = 142/783 (18%)
Query: 13 IIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGP 72
II K++ F L CL + D FP ++S+ +K +WKRP ++ P
Sbjct: 53 IIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSL---FYSQKFPIQFVWKRPPEICENP 109
Query: 73 PHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFW 131
FI+D +R DI QG DCWFLAA+ LT N +++ QSF YAGIF F+FW
Sbjct: 110 -RFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFW 168
Query: 132 QCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDA 191
+ G+WV+VVIDD LP ++ +F + H+N EFW LLEKAYAKL GSY L G +A
Sbjct: 169 RYGEWVDVVIDDCLPTYNNQLVFTKSNHRN-EFWSALLEKAYAKLHGSYEALKGGNTTEA 227
Query: 192 LVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCA-----------TPSG------- 233
+ D TGGV + +P D+ K +K A + GSL+ C+ +PSG
Sbjct: 228 MEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELI 287
Query: 234 -------------------------------PTDTAQAMENGLVSLHAYTVTGAEQIQYR 262
P M GLV HAY+VTG +++ ++
Sbjct: 288 ARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK 347
Query: 263 RGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQL-HKKREDGEFWMSCQDFQ 321
+++ L NP WG+ EW G WSD ++W K++L H+ EDGEFWMS +DF
Sbjct: 348 GEKVKLVRLRNP--WGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFI 405
Query: 322 QKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-------DAQFNFS 374
F + IC+ L + W+ + + + G +AGG RN + Q+
Sbjct: 406 YHFTKLEICNLTADALQSDKL--QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463
Query: 375 VQEPME--GTNVVVCVTVAVTPSNLKAEDAK-----FPLDFQVILAGSQRF--REKFPPV 425
+ E + + V+C + + +D K F + F + + ++
Sbjct: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 523
Query: 426 FFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLLRIFLKMPDSDRH 483
FF + +S R + + L P YV+V T + EF+LR+F + +
Sbjct: 524 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 583
Query: 484 LSSHFNL-----------------------------------------RMKGSP------ 496
+ + ++ + K SP
Sbjct: 584 VENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGS 643
Query: 497 ----SEHGSQ-QSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDM----FSLDECRSLV 547
SE Q ++IF + A ++I A +L+ +LN + D+ F+L+ CRS++
Sbjct: 644 SDQESEEQQQFRNIFKQIAGDDMEICADELKKVLN--TVVNKHKDLKTHGFTLESCRSMI 701
Query: 548 ALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQT-SPGVLLSSDLWKAIENTDFLRGIF 606
ALM+ +G+L+ +EF LW ++ +Q +F+ T G + S ++ A+ + G
Sbjct: 702 ALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDA----GFH 757
Query: 607 ISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLY-LTEMEWMSL 665
++ +L ++T+RY+D + F S +C +RLE M + F KDG G+ L +EW+ L
Sbjct: 758 LNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQL 817
Query: 666 VMY 668
MY
Sbjct: 818 TMY 820
>gi|47078247 calpain 3 isoform f [Homo sapiens]
Length = 728
Score = 284 bits (727), Expect = 2e-76
Identities = 207/717 (28%), Positives = 328/717 (45%), Gaps = 132/717 (18%)
Query: 73 PHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFW 131
P FI+D +R DI QG DCWFLAA+ LT N +++ QSF YAGIF F+FW
Sbjct: 22 PRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFW 81
Query: 132 QCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDA 191
+ G+WV+VVIDD LP ++ +F + H+N EFW LLEKAYAKL GSY L G +A
Sbjct: 82 RYGEWVDVVIDDCLPTYNNQLVFTKSNHRN-EFWSALLEKAYAKLHGSYEALKGGNTTEA 140
Query: 192 LVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCA-----------TPSG------- 233
+ D TGGV + +P D+ K +K A + GSL+ C+ +PSG
Sbjct: 141 MEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELI 200
Query: 234 -------------------------------PTDTAQAMENGLVSLHAYTVTGAEQIQYR 262
P M GLV HAY+VTG +++ ++
Sbjct: 201 ARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFK 260
Query: 263 RGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQL-HKKREDGEFWMSCQDFQ 321
+++ L NP WG+ EW G WSD ++W K++L H+ EDGEFWMS +DF
Sbjct: 261 GEKVKLVRLRNP--WGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFI 318
Query: 322 QKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-------DAQFNFS 374
F + IC+ L + W+ + + + G +AGG RN + Q+
Sbjct: 319 YHFTKLEICNLTADALQSDKL--QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 376
Query: 375 VQEPME--GTNVVVCVTVAVTPSNLKAEDAK-----FPLDFQVILAGSQRF--REKFPPV 425
+ E + + V+C + + +D K F + F + + ++
Sbjct: 377 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 436
Query: 426 FFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLLRIFLKMPDSDRH 483
FF + +S R + + L P YV+V T + EF+LR+F + +
Sbjct: 437 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 496
Query: 484 LSSHFNL-----------------------------------RMKGSP----------SE 498
+ + ++ + K SP SE
Sbjct: 497 VENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE 556
Query: 499 HGSQ-QSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDM----FSLDECRSLVALMELK 553
Q ++IF + A ++I A +L+ +LN + D+ F+L+ CRS++ALM+
Sbjct: 557 EQQQFRNIFKQIAGDDMEICADELKKVLN--TVVNKHKDLKTHGFTLESCRSMIALMDTD 614
Query: 554 VNGRLDQEEFARLWKRLVHYQHVFQKVQT-SPGVLLSSDLWKAIENTDFLRGIFISRELL 612
+G+L+ +EF LW ++ +Q +F+ T G + S ++ A+ + G ++ +L
Sbjct: 615 GSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDA----GFHLNNQLY 670
Query: 613 HLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLY-LTEMEWMSLVMY 668
++T+RY+D + F S +C +RLE M + F KDG G+ L +EW+ L MY
Sbjct: 671 DIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 727
>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
Length = 664
Score = 276 bits (706), Expect = 4e-74
Identities = 206/683 (30%), Positives = 330/683 (48%), Gaps = 81/683 (11%)
Query: 19 QDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILD 78
Q F +R CL G F+D FPA++SS+ E+ +WKRP ++ P FIL
Sbjct: 27 QSFEQMRQECLQRGTLFEDADFPASNSSL---FYSERPQIPFVWKRPGEIVKNP-EFILG 82
Query: 79 DISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL-MVQSFSHQYAGIFRFRFWQCGQWV 137
+R DI QG DCW LAA+ SLT N + +++ QSF YAGIF F+FWQ +W+
Sbjct: 83 GATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWL 142
Query: 138 EVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTG 197
+VVIDDRLP D+ +F+ N EFW LLEKAYAKL GSY L G +A+ D TG
Sbjct: 143 DVVIDDRLPTFRDRLVFLHSADHN-EFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
Query: 198 GVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMEN------GLVSLHAY 251
GV +P + + ++ A K GSL+ C DT A E+ GL+ HAY
Sbjct: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCF-----IDTRSAAESEARTPFGLIKGHAY 256
Query: 252 TVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKREDG 311
+VTG +Q+ +R E+I + NP WG+ EW G WSD
Sbjct: 257 SVTGIDQVSFRGQRIELIRIRNP--WGQVEWNGSWSDR---------------------- 292
Query: 312 EFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN---- 367
M+ +DF+ F + IC+ P L+ + +H+ W + + + G+TAGG RN
Sbjct: 293 ---MAFKDFKAHFDKVEICNLTPDALEE-DAIHK-WEVTVHQGSWVRGSTAGGCRNFLDT 347
Query: 368 ---DAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFR----- 419
+ Q S+ E EG + + K + V+ G +
Sbjct: 348 FWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLK----RFGANVLTIGYAIYECPDKD 403
Query: 420 EKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLLRIFLKM 477
E FF + +S R + + L PG Y+++ T + A+F LRIF +
Sbjct: 404 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 463
Query: 478 PDSDRHLSSHFNLRM----KGSPSEHGSQQ-----SIFNRYAQQRLDIDATQLQGLLNQE 528
R + + ++ + K +P + +++ ++F + A + +++ A +L+ +LN
Sbjct: 464 KAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAV 523
Query: 529 LLTGP--PGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQT-SPG 585
L SL C+++++LM+ NG+L+ +EF W +L + ++F + G
Sbjct: 524 LQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSG 583
Query: 586 VLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTF 645
+ + +L A++ G +S LL L+ LRY+D ++ F + L+RLE ++ F
Sbjct: 584 TMSTYELRTALK----AAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVF 639
Query: 646 RNLS-KDGKGLYLTEMEWMSLVM 667
+ LS K+ + ++L E++ L M
Sbjct: 640 QALSTKNKEFIHLNINEFIHLTM 662
>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
Length = 622
Score = 275 bits (703), Expect = 1e-73
Identities = 186/620 (30%), Positives = 296/620 (47%), Gaps = 38/620 (6%)
Query: 73 PHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFW 131
P FI+ +R DI QG DCW LAA+ SLT N + +++ + QSF YAGIF F+FW
Sbjct: 7 PQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFW 66
Query: 132 QCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDA 191
Q G+WVEVV+DDRLP + + LFV + EFW LLEKAYAK+ G Y L G +
Sbjct: 67 QYGEWVEVVVDDRLPTKDGELLFVHSA-EGSEFWSALLEKAYAKINGCYEALSGGATTEG 125
Query: 192 LVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATP-SGPTDTAQAMENGLVSLHA 250
D TGG+ L P +L K ++ A + GSL+ C+ + D+ LV HA
Sbjct: 126 FEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHA 185
Query: 251 YTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRED 310
Y+VTGAE+++ +++I + NPWG E EW GRW+D W + +L ++ ED
Sbjct: 186 YSVTGAEEVESNGSLQKLIRIRNPWG--EVEWTGRWNDNCPSWNTIDPEERERLTRRHED 243
Query: 311 GEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN--- 367
GEFWMS DF + + + IC+ P TL + ++ W G+TAGG RN
Sbjct: 244 GEFWMSFSDFLRHYSRLEICNLTPDTLT--SDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301
Query: 368 ----DAQFNFSVQEPMEG--TNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFREK 421
+ Q+ ++E E C + + K D I G E+
Sbjct: 302 TFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEE 361
Query: 422 --------FPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLL 471
FF + R +S R + L PG Y++V T K +F +
Sbjct: 362 LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCI 421
Query: 472 RIFLKMPDSDRHLSSHFNLRMK----GSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQ 527
R+F + + + ++ + +F + A + +I A +LQ +L +
Sbjct: 422 RVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR 481
Query: 528 ELLTGP--PGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTS-P 584
L D FS++ C+ +V +++ +G+L +EF LW ++ YQ +++++
Sbjct: 482 VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRS 541
Query: 585 GVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKT 644
G + S ++ KA+E G + +L ++ R++D + F + V L+RLE + K
Sbjct: 542 GTMNSYEMRKALEEA----GFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKI 597
Query: 645 FRNLSKDGKG-LYLTEMEWM 663
F+ L + G + L + W+
Sbjct: 598 FKQLDPENTGTIELDLISWL 617
>gi|38707981 calpain 12 [Homo sapiens]
Length = 719
Score = 268 bits (685), Expect = 1e-71
Identities = 218/710 (30%), Positives = 329/710 (46%), Gaps = 73/710 (10%)
Query: 16 FKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLL--QEKRLSNVIWKRPQDLPGGPP 73
F+ Q + +R CL G F+D FPA ++G L ++ V W RP + P
Sbjct: 27 FRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCA-EP 85
Query: 74 HFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFWQ 132
FI +D+SR D+ QG +CWFLAA SLT P+ ++++ Q F H YAG+F F+ WQ
Sbjct: 86 KFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQ 145
Query: 133 CGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDAL 192
G+W++VV+DDRLPV+ K +FVR +N EFW LLEKAYAKL GSY + G + +A
Sbjct: 146 FGRWMDVVVDDRLPVREGKLMFVRSEQRN-EFWAPLLEKAYAKLHGSYEVMRGGHMNEAF 204
Query: 193 VDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLI--TCATPSGPTDTAQAMENGLVSLHA 250
VD TGGV ++L + + L A++ A SL+ T + G T E GLV HA
Sbjct: 205 VDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGATALSDRGEYRT----EEGLVKGHA 260
Query: 251 YTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRED 310
Y++TG ++ ++ L NPWG EW G WSD W+ + L K+ED
Sbjct: 261 YSITGTHKVFLGFTKVRLLRLRNPWGC--VEWTGAWSDSCPRWDTLPTECRDALLVKKED 318
Query: 311 GEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRNDA- 369
GEFWM +DF F + ICS P L + GW F+ + + G +GG + +A
Sbjct: 319 GEFWMELRDFLLHFDTVQICSLSPEVLG-PSPEGGGWHVHTFQGRWVRGFNSGGSQPNAE 377
Query: 370 ------QFNFSVQEPME------------------------GTNVVVCVTVAVTPSNLKA 399
QF ++ EP E G V +++ N +
Sbjct: 378 TFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRR 437
Query: 400 EDAK----FPLDFQVILAGSQRFREKFPPVFFSSFRNTVQSSNNKF--RRNFTMTYHLSP 453
AK + F V + P + +++ + RR+ T L P
Sbjct: 438 LRAKGLTYLTVGFHVFQIPEELLGLWDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRP 497
Query: 454 GNYVVVAQTRR--KSAEFLLRIFLK----MPDSDRHLSSHF-NLRMKGSPSEHGSQQSIF 506
G+Y+VV T A+F LR+F + + D +S+ +L+ P E G +Q +F
Sbjct: 498 GHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLPLELGLEQ-LF 556
Query: 507 NRYAQQRLDIDATQLQGLLNQEL-----LTGPPGDMFSLDECRSLVALMELKVNGRLDQE 561
A + +++A+QLQ LL+ L T P ++ L C L L L
Sbjct: 557 QELAGEEEELNASQLQALLSIALEPARAHTSTPREI-GLRTCEQL--LQCFGHGQSLALH 613
Query: 562 EFARLWKRLVHYQHVFQKV-QTSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYS 620
F +LW L+ +Q +F K + + G + S +L A+ G ++ +L +T RY
Sbjct: 614 HFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALN----AAGFHLNNQLTQTLTSRYR 669
Query: 621 DSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKG-LYLTEMEWMSLVMYN 669
DS RV F V + L + G+G + LT +WM + ++
Sbjct: 670 DSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719
>gi|37577157 calpain 5 [Homo sapiens]
Length = 640
Score = 201 bits (510), Expect = 2e-51
Identities = 157/518 (30%), Positives = 236/518 (45%), Gaps = 76/518 (14%)
Query: 16 FKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHF 75
++DQ+++ LR C F+D FPA D S+ K V WKRP+ + P F
Sbjct: 8 YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA---VRWKRPKGICEDPRLF 64
Query: 76 ILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL---MVQSFSHQ----YAGIFRF 128
+ D IS D+ QG +CWF+AA SL QK++ Q + + YAGIF F
Sbjct: 65 V-DGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHF 123
Query: 129 RFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFL 188
FW+ G+WV+VVIDDRLP ++ ++ +N EFW L+EKAYAKL G Y L G
Sbjct: 124 HFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRN-EFWCALVEKAYAKLAGCYQALDGGNT 182
Query: 189 EDALVDLTGGVITNIHLHSSPVDLV----------------KAVKTATKAGSLITCATPS 232
DALVD TGGV S P+DL + +K ++ G +
Sbjct: 183 ADALVDFTGGV-------SEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAV 235
Query: 233 GPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGW--------EEIISLWNPWGWGEAEWRG 284
D + GLV HAY VT +++ G ++I L NP WGE EW G
Sbjct: 236 TAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNP--WGEREWNG 293
Query: 285 RWSDGSQEWEETCDPRKSQLH-KKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTL 343
WSD S+EW++ + ++ ++DGEFWM+ +D + F + C I + ++
Sbjct: 294 PWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTS---HLSI 350
Query: 344 HEGWSQIMFRKQVIL-----GNTAGGPRN-------DAQFNFSVQEPMEGTNVVVCVTVA 391
H+ W + L N GG N + Q+ F V++P + V++C+
Sbjct: 351 HKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPED--EVLICIQQR 408
Query: 392 VTPSNL---KAEDAKFPLDFQVILAGSQRFREKFPPVFFSSFRNTVQSSNNKFRRNFTMT 448
S K E+ D + ++++R S ++ SS R+ +
Sbjct: 409 PKRSTRREGKGENLAIGFDIYKV-EENRQYR-------MHSLQHKAASSIYINSRSVFLR 460
Query: 449 YHLSPGNYVVVAQTRR--KSAEFLLRIFLKMPDSDRHL 484
G YV++ T + EFLLR+F +P + R L
Sbjct: 461 TDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCREL 498
>gi|13186316 calpain 6 [Homo sapiens]
Length = 641
Score = 177 bits (448), Expect = 4e-44
Identities = 162/512 (31%), Positives = 232/512 (45%), Gaps = 63/512 (12%)
Query: 16 FKDQDFTTLRDHCLSMGRTFKDETF-PAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPH 74
FK+Q + L+ C+ R F D TF P DS +LL K V+WKRPQD+ P H
Sbjct: 8 FKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK----VVWKRPQDICDDP-H 62
Query: 75 FILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL---MVQSFSHQ----YAGIFR 127
I+ +IS + QG ++A L + K + Q + Q YAGIF
Sbjct: 63 LIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFH 122
Query: 128 FRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGF 187
FRFW G+W EVVIDD LP +F N EFW LLEKAYAKLLG Y L
Sbjct: 123 FRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMN-EFWNALLEKAYAKLLGCYEALDGLT 181
Query: 188 LEDALVDLTGGVITNIHLHSSP-VDLV--------KAVKTATKAGSLITCATPSGPTDTA 238
+ D +VD TG + + + +LV + KT TK G + C + P
Sbjct: 182 ITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGG--LICCSIESPNQEE 239
Query: 239 QAMEN--GLVSLHAYTVTGAEQIQYRRGWEEIIS--------LWNPWGWGEAEWRGRWSD 288
Q +E GL+ H YT+T +I+ E+ S L NP G EW G WS+
Sbjct: 240 QEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNP--LGRQEWSGPWSE 297
Query: 289 GSQEWEE-TCDPRKSQLHKKREDGEFWMSCQDFQQKFIAMFICSEI--PITLDHGNTLHE 345
S+EW++ T RK+ +DGEFWMS +DF + F + +C + PI G E
Sbjct: 298 ISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPI---FGRKELE 354
Query: 346 GWSQIMFRKQVILGNTAGGPRN-------DAQFNFSVQEPMEGTNVVVCVTVAVTPSNLK 398
L N +GG N + Q+ F+V P +G V+ +++ +L+
Sbjct: 355 SVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTV--PEDGHKVI----MSLQQKDLR 408
Query: 399 AEDAKFPLDFQVILAGSQRFREKFPPVF---FSSFRNTVQSSNNKFRRNFTMTYHLSPGN 455
D +I G + F+ + F + +S R ++ +L GN
Sbjct: 409 TYRRMGRPDNYII--GFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGN 466
Query: 456 YVVVAQ--TRRKSAEFLLRIFLKMPDSDRHLS 485
YV+V +++EFLLRIF ++P R L+
Sbjct: 467 YVLVPTMFQHGRTSEFLLRIFSEVPVQLRELT 498
>gi|13186302 calpain 10 isoform a [Homo sapiens]
Length = 672
Score = 155 bits (391), Expect = 1e-37
Identities = 149/501 (29%), Positives = 220/501 (43%), Gaps = 89/501 (17%)
Query: 35 FKDETFPAADSSIGQKL---LQEKRLSNVIWKRPQDLPGGPPHFILDDISRFDIQQGGAA 91
F+D FPAADSS+ L L + R ++ W+RPQ++ P F DD ++QG
Sbjct: 14 FRDAAFPAADSSLFCDLSTPLAQFR-EDITWRRPQEICATPRLFP-DDPREGQVKQGLLG 71
Query: 92 DCWFLAALGSLTQNPQYRQKILMVQSFS---HQYAGIFRFRFWQCGQWVEVVIDDRLPVQ 148
DCWFL A +L ++ +++ S +Y G F R WQ G+WVEV DDRLP
Sbjct: 72 DCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCL 131
Query: 149 GDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTGGVITNIHL--- 205
+ F R + ++ FW LLEK YAK+ GSY L G + DALVDLTGG+ +L
Sbjct: 132 AGRLCFSRCQREDV-FWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGV 190
Query: 206 --------------HSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAY 251
H + L+ K LI+C S A A E G HA+
Sbjct: 191 AGSGGQQDRPGRWEHRTCRQLLH-----LKDQCLISCCVLS---PRAGARELG--EFHAF 240
Query: 252 TVTGAEQIQYRRG-WEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRED 310
V+ ++Q + G ++ + NP WG W+G W +G + W + S+L + ++
Sbjct: 241 IVSDLRELQGQAGQCILLLRIQNP--WGRRCWQGLWREGGEGWSQVDAAVASELLSQLQE 298
Query: 311 GEFWMSCQDFQQKFIAMFICSEIPIT-------------LDHGNTLHEGWSQIMFRKQVI 357
GEFW+ ++F ++F + + P+T L H L W +
Sbjct: 299 GEFWVEEEEFLREFDELTV--GYPVTEAGHLQSLYTERLLCHTRALPGAW---------V 347
Query: 358 LGNTAGGPRNDA------QFNFSVQEPMEGTNVVV------------CVTVAVTPSNLKA 399
G +AGG RN++ +F V EP E V+ V S+
Sbjct: 348 KGQSAGGCRNNSGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSW 407
Query: 400 EDAKFP-LDFQVI---LAGSQRFREKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGN 455
A P +Q + L ++ R P V S ++ + + R + LSPG
Sbjct: 408 SPASIPGKHYQAVGLHLWKVEKRRVNLPRVL--SMPPVAGTACHAYDREVHLRCELSPGY 465
Query: 456 YVVVAQTRRKSA--EFLLRIF 474
Y+ V T K A EFLLR+F
Sbjct: 466 YLAVPSTFLKDAPGEFLLRVF 486
>gi|89353291 calpain 10 isoform c [Homo sapiens]
Length = 517
Score = 148 bits (373), Expect = 2e-35
Identities = 122/389 (31%), Positives = 180/389 (46%), Gaps = 69/389 (17%)
Query: 35 FKDETFPAADSSIGQKL---LQEKRLSNVIWKRPQDLPGGPPHFILDDISRFDIQQGGAA 91
F+D FPAADSS+ L L + R ++ W+RPQ++ P F DD ++QG
Sbjct: 14 FRDAAFPAADSSLFCDLSTPLAQFR-EDITWRRPQEICATPRLFP-DDPREGQVKQGLLG 71
Query: 92 DCWFLAALGSLTQNPQYRQKILMVQSFS---HQYAGIFRFRFWQCGQWVEVVIDDRLPVQ 148
DCWFL A +L ++ +++ S +Y G F R WQ G+WVEV DDRLP
Sbjct: 72 DCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCL 131
Query: 149 GDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTGGVITNIHL--- 205
+ F R + ++ FW LLEK YAK+ GSY L G + DALVDLTGG+ +L
Sbjct: 132 AGRLCFSRCQREDV-FWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGV 190
Query: 206 --------------HSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAY 251
H + L+ K LI+C S A A E G HA+
Sbjct: 191 AGSGGQQDRPGRWEHRTCRQLLH-----LKDQCLISCCVLS---PRAGARELG--EFHAF 240
Query: 252 TVTGAEQIQYRRG-WEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRED 310
V+ ++Q + G ++ + NP WG W+G W +G + W + S+L + ++
Sbjct: 241 IVSDLRELQGQAGQCILLLRIQNP--WGRRCWQGLWREGGEGWSQVDAAVASELLSQLQE 298
Query: 311 GEFWMSCQDFQQKFIAMFICSEIPIT-------------LDHGNTLHEGWSQIMFRKQVI 357
GEFW+ ++F ++F + + P+T L H L W +
Sbjct: 299 GEFWVEEEEFLREFDELTV--GYPVTEAGHLQSLYTERLLCHTRALPGAW---------V 347
Query: 358 LGNTAGGPRNDA------QFNFSVQEPME 380
G +AGG RN++ +F V EP E
Sbjct: 348 KGQSAGGCRNNSGFPSNPKFWLRVSEPSE 376
>gi|5032105 small optic lobes [Homo sapiens]
Length = 1086
Score = 120 bits (300), Expect = 5e-27
Identities = 94/321 (29%), Positives = 142/321 (44%), Gaps = 29/321 (9%)
Query: 28 CLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGG------PPHFILDDIS 81
C +F D++FP S+G + W RPQ++ + +
Sbjct: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540
Query: 82 RFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVI 141
DI QG +CWFL+AL L + P +++++ +S + G ++ R + G W V++
Sbjct: 541 PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE--GAYQVRLCKDGTWTTVLV 598
Query: 142 DDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTGGVIT 201
DD LP CL + Q ++ W L+EKA AKL GSY L G + L LTG
Sbjct: 599 DDMLPCDEAGCLLFS-QAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCE 657
Query: 202 NIHLHSS-------PV--DLVKAVKTATK-AGSLI--TCATPSGPTDTAQAMENGLVSLH 249
++ L S PV DL+ A ++K AG L+ +C + D + GL H
Sbjct: 658 SLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRH 717
Query: 250 AYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRE 309
AY++ +Q R ++ L NP WG W G WSD W R +
Sbjct: 718 AYSILDVRDVQGTR----LLRLRNP--WGRFSWNGSWSDEWPHWPGHL--RGELMPHGSS 769
Query: 310 DGEFWMSCQDFQQKFIAMFIC 330
+G FWM DF + F ++ IC
Sbjct: 770 EGVFWMEYGDFVRYFDSVDIC 790
>gi|4502565 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 102 bits (253), Expect = 1e-21
Identities = 60/189 (31%), Positives = 106/189 (56%), Gaps = 10/189 (5%)
Query: 486 SHFNLRMKGSPSEHGSQ-QSIFNRYAQQRLDIDATQLQGLLNQELLTGPP--GDMFSLDE 542
+H++ ++ + SE Q + +F + A +++ AT+L +LN+ + P D F +D
Sbjct: 85 THYS-NIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDT 143
Query: 543 CRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTS-PGVLLSSDLWKAIENTDF 601
CRS+VA+M+ G+L EEF LW + +Q ++++ T G + SS+L A E
Sbjct: 144 CRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAA-- 201
Query: 602 LRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKG-LYLTEM 660
G ++ L +++ RYSD G + F + + L+RL+AM + F++L KDG G + +
Sbjct: 202 --GFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQ 259
Query: 661 EWMSLVMYN 669
EW+ L MY+
Sbjct: 260 EWLQLTMYS 268
>gi|51599151 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 102 bits (253), Expect = 1e-21
Identities = 60/189 (31%), Positives = 106/189 (56%), Gaps = 10/189 (5%)
Query: 486 SHFNLRMKGSPSEHGSQ-QSIFNRYAQQRLDIDATQLQGLLNQELLTGPP--GDMFSLDE 542
+H++ ++ + SE Q + +F + A +++ AT+L +LN+ + P D F +D
Sbjct: 85 THYS-NIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDT 143
Query: 543 CRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTS-PGVLLSSDLWKAIENTDF 601
CRS+VA+M+ G+L EEF LW + +Q ++++ T G + SS+L A E
Sbjct: 144 CRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAA-- 201
Query: 602 LRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKG-LYLTEM 660
G ++ L +++ RYSD G + F + + L+RL+AM + F++L KDG G + +
Sbjct: 202 --GFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQ 259
Query: 661 EWMSLVMYN 669
EW+ L MY+
Sbjct: 260 EWLQLTMYS 268
>gi|7656959 calpain 7 [Homo sapiens]
Length = 813
Score = 99.0 bits (245), Expect = 1e-20
Identities = 105/394 (26%), Positives = 163/394 (41%), Gaps = 46/394 (11%)
Query: 62 WKRPQDLPGGPPHFILDDISRFDIQQGGAADCWFLAALG-SLTQNPQYRQKILMVQSFSH 120
W RP+DL P ++ +S F I+Q +DC F+A+L S ++ +K++ +
Sbjct: 261 WVRPEDLTNNPT--MIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQ 318
Query: 121 QYAGIFRFRFWQCGQWV----------EVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLE 170
G + CG+++ +V+IDD+LPV L + E W L+E
Sbjct: 319 NKDGEPEYN--PCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIE 376
Query: 171 KAYAKLLGSYSDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVK------AVKTATKAGS 224
KAY K++G Y D L LTG + I +HS K + K
Sbjct: 377 KAYMKVMGGY-DFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDV 435
Query: 225 LITCATPSGPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRG 284
LIT +T G A+ + GLV HAY V + + R I L NP W W+G
Sbjct: 436 LITAST--GMMTEAEGEKWGLVPTHAYAVLDIREFKGLR----FIQLKNP--WSHLRWKG 487
Query: 285 RWSDGS-QEWEE------TCDPRKSQLHKKREDGEFWMSCQDFQQKFIAMFICSEIPITL 337
R+S+ + W DPR +Q K ++G FW+S D Q + +++ S P
Sbjct: 488 RYSENDVKNWTPELQKYLNFDPRTAQ---KIDNGIFWISWDDLCQYYDVIYL-SWNPGLF 543
Query: 338 DHGNTLHEGWSQIMFRKQVILGNTAGGPRNDAQFNFSVQEPMEGTNVVVCVTVAVTPSNL 397
+H W KQ + A N+ Q+ VQ P G V V ++ +T +
Sbjct: 544 KESTCIHSTWD----AKQGPV-KDAYSLANNPQYKLEVQCPQGGAAVWVLLSRHITDKDD 598
Query: 398 KAEDAKFPLDFQVILAGSQRFREKFPPVFFSSFR 431
A + +F G + + PP + R
Sbjct: 599 FANNREFITMVVYKTDGKKVYYPADPPPYIDGIR 632
>gi|27765076 calpain 3 isoform d [Homo sapiens]
Length = 309
Score = 95.5 bits (236), Expect = 1e-19
Identities = 56/185 (30%), Positives = 100/185 (54%), Gaps = 16/185 (8%)
Query: 494 GSPSEHGSQQ----SIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDM----FSLDECRS 545
GS + +Q +IF + A ++I A +L+ +LN + D+ F+L+ CRS
Sbjct: 130 GSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCRS 187
Query: 546 LVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSP-GVLLSSDLWKAIENTDFLRG 604
++ALM+ +G+L+ +EF LW ++ +Q +F+ T G + S ++ A+ + G
Sbjct: 188 MIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDA----G 243
Query: 605 IFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLY-LTEMEWM 663
++ +L ++T+RY+D + F S +C +RLE M + F KDG G+ L +EW+
Sbjct: 244 FHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 303
Query: 664 SLVMY 668
L MY
Sbjct: 304 QLTMY 308
>gi|27765080 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 90.5 bits (223), Expect = 4e-18
Identities = 44/133 (33%), Positives = 77/133 (57%), Gaps = 6/133 (4%)
Query: 538 FSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSP-GVLLSSDLWKAI 596
F+L+ CRS++ALM+ +G+L+ +EF LW ++ +Q +F+ T G + S ++ A+
Sbjct: 27 FTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAV 86
Query: 597 ENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLY 656
+ G ++ +L ++T+RY+D + F S +C +RLE M + F KDG G+
Sbjct: 87 NDA----GFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGII 142
Query: 657 -LTEMEWMSLVMY 668
L +EW+ L MY
Sbjct: 143 KLNVLEWLQLTMY 155
>gi|27765078 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 90.5 bits (223), Expect = 4e-18
Identities = 44/133 (33%), Positives = 77/133 (57%), Gaps = 6/133 (4%)
Query: 538 FSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSP-GVLLSSDLWKAI 596
F+L+ CRS++ALM+ +G+L+ +EF LW ++ +Q +F+ T G + S ++ A+
Sbjct: 27 FTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAV 86
Query: 597 ENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLY 656
+ G ++ +L ++T+RY+D + F S +C +RLE M + F KDG G+
Sbjct: 87 NDA----GFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGII 142
Query: 657 -LTEMEWMSLVMY 668
L +EW+ L MY
Sbjct: 143 KLNVLEWLQLTMY 155
>gi|14161692 calpain small subunit 2 [Homo sapiens]
Length = 248
Score = 87.4 bits (215), Expect = 4e-17
Identities = 60/197 (30%), Positives = 105/197 (53%), Gaps = 14/197 (7%)
Query: 478 PDSDRHLSSHFNLRMKGSPSEHGSQ-QSIFNRYAQQRLDIDATQLQGLLNQELLTGPP-- 534
P + +H +S ++ S SE + + F + A +++ AT L +LN+ L
Sbjct: 61 PPTQQHFTS-----VEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLK 115
Query: 535 GDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKV-QTSPGVLLSSDLW 593
D FSLD CRS+V++M+ G+L EEF LW + +Q V+++ + G L SS L
Sbjct: 116 TDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLR 175
Query: 594 KAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGK 653
A++ G ++ +L ++ RY++ G + F + + L+RL+AM + F++L +D
Sbjct: 176 GALQ----AAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRD 231
Query: 654 GLYLTEM-EWMSLVMYN 669
GL + EW+ L MY+
Sbjct: 232 GLIQVSIKEWLQLTMYS 248
>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
sapiens]
Length = 217
Score = 56.2 bits (134), Expect = 9e-08
Identities = 44/147 (29%), Positives = 71/147 (48%), Gaps = 7/147 (4%)
Query: 501 SQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSLDECRSLVALMELKVNGRLDQ 560
S + F+ A Q ++DA +LQ L Q + G FSL+ CR ++A+++ G++
Sbjct: 53 SVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYSP-FSLETCRIMIAMLDRDHTGKMGF 111
Query: 561 EEFARLWKRLVHYQHVFQKV-QTSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRY 619
F LW L ++ F V Q G + +L +AI L G +S + L + RY
Sbjct: 112 NAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIG----LMGYRLSPQTLTTIVKRY 167
Query: 620 SDSVGRVSFPSLVCFLMRLEAMAKTFR 646
S + GR+ F V ++L A+ FR
Sbjct: 168 SKN-GRIFFDDYVACCVKLRALTDFFR 193
>gi|38679884 sorcin isoform b [Homo sapiens]
Length = 183
Score = 53.5 bits (127), Expect = 6e-07
Identities = 44/167 (26%), Positives = 78/167 (46%), Gaps = 11/167 (6%)
Query: 494 GSPSEHGSQQS----IFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSLDECRSLVAL 549
G P+ G Q F A Q IDA +LQ L Q + G F+L+ CR +V++
Sbjct: 8 GGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-FNLETCRLMVSM 66
Query: 550 MELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTS-PGVLLSSDLWKAIENTDFLRGIFIS 608
++ ++G + EF LW L ++ F T G + +L KA+ G +S
Sbjct: 67 LDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTT----MGFRLS 122
Query: 609 RELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGL 655
+ ++ + RYS + G+++F + ++L A+ +FR +G+
Sbjct: 123 PQAVNSIAKRYSTN-GKITFDDYIACCVKLRALTDSFRRRDTAQQGV 168
>gi|4507207 sorcin isoform a [Homo sapiens]
Length = 198
Score = 53.5 bits (127), Expect = 6e-07
Identities = 44/167 (26%), Positives = 78/167 (46%), Gaps = 11/167 (6%)
Query: 494 GSPSEHGSQQS----IFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSLDECRSLVAL 549
G P+ G Q F A Q IDA +LQ L Q + G F+L+ CR +V++
Sbjct: 23 GGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-FNLETCRLMVSM 81
Query: 550 MELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTS-PGVLLSSDLWKAIENTDFLRGIFIS 608
++ ++G + EF LW L ++ F T G + +L KA+ G +S
Sbjct: 82 LDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTT----MGFRLS 137
Query: 609 RELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGL 655
+ ++ + RYS + G+++F + ++L A+ +FR +G+
Sbjct: 138 PQAVNSIAKRYSTN-GKITFDDYIACCVKLRALTDSFRRRDTAQQGV 183
>gi|13186314 calpain 10 isoform g [Homo sapiens]
Length = 139
Score = 48.1 bits (113), Expect = 3e-05
Identities = 29/74 (39%), Positives = 42/74 (56%), Gaps = 5/74 (6%)
Query: 35 FKDETFPAADSSIGQKL---LQEKRLSNVIWKRPQDLPGGPPHFILDDISRFDIQQGGAA 91
F+D FPAADSS+ L L + R ++ W+RPQ++ P F DD ++QG
Sbjct: 14 FRDAAFPAADSSLFCDLSTPLAQFR-EDITWRRPQEICATPRLFP-DDPREGQVKQGLLG 71
Query: 92 DCWFLAALGSLTQN 105
DCWFL A +L ++
Sbjct: 72 DCWFLCACAALQKS 85
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,914,405
Number of Sequences: 37866
Number of extensions: 1206664
Number of successful extensions: 2581
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2399
Number of HSP's gapped (non-prelim): 58
length of query: 669
length of database: 18,247,518
effective HSP length: 109
effective length of query: 560
effective length of database: 14,120,124
effective search space: 7907269440
effective search space used: 7907269440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.