Search of human proteins with 38707981

Search of human proteins with 38707981

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38707981 calpain 12 [Homo sapiens]
         (719 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38707981 calpain 12 [Homo sapiens]                                1495   0.0  
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       553   e-157
gi|12408656 calpain 1, large subunit [Homo sapiens]                   549   e-156
gi|221554549 calpain 8 [Homo sapiens]                                 535   e-152
gi|215490104 calpain 11 [Homo sapiens]                                528   e-150
gi|27765074 calpain 3 isoform c [Homo sapiens]                        508   e-144
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       487   e-137
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                         487   e-137
gi|4557405 calpain 3 isoform a [Homo sapiens]                         480   e-135
gi|27765072 calpain 3 isoform b [Homo sapiens]                        478   e-135
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                         455   e-128
gi|47078247 calpain 3 isoform f [Homo sapiens]                        454   e-127
gi|223468608 calpain 14 [Homo sapiens]                                383   e-106
gi|37577157 calpain 5 [Homo sapiens]                                  270   3e-72
gi|41152101 calpain 13 [Homo sapiens]                                 268   1e-71
gi|13186302 calpain 10 isoform a [Homo sapiens]                       236   4e-62
gi|89353291 calpain 10 isoform c [Homo sapiens]                       231   2e-60
gi|13186316 calpain 6 [Homo sapiens]                                  229   5e-60
gi|5032105 small optic lobes [Homo sapiens]                           167   3e-41
gi|27765076 calpain 3 isoform d [Homo sapiens]                        135   2e-31
gi|27765080 calpain 3 isoform e [Homo sapiens]                        100   8e-21
gi|27765078 calpain 3 isoform e [Homo sapiens]                        100   8e-21
gi|4502565 calpain, small subunit 1 [Homo sapiens]                     96   9e-20
gi|51599151 calpain, small subunit 1 [Homo sapiens]                    96   9e-20
gi|14161692 calpain small subunit 2 [Homo sapiens]                     91   5e-18
gi|7656959 calpain 7 [Homo sapiens]                                    89   2e-17
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap...    66   1e-10
gi|13186314 calpain 10 isoform g [Homo sapiens]                        65   2e-10
gi|38679884 sorcin isoform b [Homo sapiens]                            63   8e-10
gi|4507207 sorcin isoform a [Homo sapiens]                             63   8e-10

>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score = 1495 bits (3871), Expect = 0.0
 Identities = 719/719 (100%), Positives = 719/719 (100%)

Query: 1   MASSSGRVTIQLVDEEAGVGAGRLQLFRGQSYEAIRAACLDSGILFRDPYFPAGPDALGY 60
           MASSSGRVTIQLVDEEAGVGAGRLQLFRGQSYEAIRAACLDSGILFRDPYFPAGPDALGY
Sbjct: 1   MASSSGRVTIQLVDEEAGVGAGRLQLFRGQSYEAIRAACLDSGILFRDPYFPAGPDALGY 60

Query: 61  DQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRL 120
           DQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRL
Sbjct: 61  DQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRL 120

Query: 121 LRRVVPPGQDFQHGYAGVFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPL 180
           LRRVVPPGQDFQHGYAGVFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPL
Sbjct: 121 LRRVVPPGQDFQHGYAGVFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPL 180

Query: 181 LEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGA 240
           LEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGA
Sbjct: 181 LEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGA 240

Query: 241 TALSDRGEYRTEEGLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPR 300
           TALSDRGEYRTEEGLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPR
Sbjct: 241 TALSDRGEYRTEEGLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPR 300

Query: 301 WDTLPTECRDALLVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQ 360
           WDTLPTECRDALLVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQ
Sbjct: 301 WDTLPTECRDALLVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQ 360

Query: 361 GRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGR 420
           GRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGR
Sbjct: 361 GRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGR 420

Query: 421 TPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRSHALLPRLLRADR 480
           TPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRSHALLPRLLRADR
Sbjct: 421 TPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRSHALLPRLLRADR 480

Query: 481 SPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQS 540
           SPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQS
Sbjct: 481 SPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQS 540

Query: 541 LQGPYLPLELGLEQLFQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQL 600
           LQGPYLPLELGLEQLFQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQL
Sbjct: 541 LQGPYLPLELGLEQLFQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQL 600

Query: 601 LQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQL 660
           LQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQL
Sbjct: 601 LQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQL 660

Query: 661 TQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719
           TQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS
Sbjct: 661 TQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  553 bits (1425), Expect = e-157
 Identities = 300/711 (42%), Positives = 417/711 (58%), Gaps = 37/711 (5%)

Query: 14  DEEAGVGAG---RLQLFRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKA 70
           D EA  G G   R   +  Q YEA+R  CL++G LF+DP FPA P ALG+ +LGP S K 
Sbjct: 11  DREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKT 70

Query: 71  KGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQD 130
           +G++W RP E CA+P+FI    +RTD+CQG+LG+CW LAA ASLTL   +L RVVP  Q 
Sbjct: 71  RGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQS 130

Query: 131 FQHGYAGVFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHG 190
           FQ  YAG+FHFQ WQ+G W++VVVDDRLP ++G+L+FV S + +EFW+ LLEKAYAK++G
Sbjct: 131 FQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKING 190

Query: 191 SYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGA----TALSDR 246
            YE + GG   E F DFTGG+ E   L++    LF  ++ AL K SL+G     T+ +D 
Sbjct: 191 CYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAAD- 249

Query: 247 GEYRTEEGLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPT 306
            E  T + LVKGHAYS+TG  +V    +  +L+R+RNPWG VEWTG W+D+CP W+T+  
Sbjct: 250 SEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDP 309

Query: 307 ECRDALLVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRG 366
           E R+ L  + EDGEFWM   DFL H+  ++IC+L+P+ L  S     W +    G W RG
Sbjct: 310 EERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTL-TSDTYKKWKLTKMDGNWRRG 368

Query: 367 FNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTV 426
             +GG +    TFW NPQ+ + L E DE++++ E G                     CT 
Sbjct: 369 STAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESG---------------------CTF 407

Query: 427 LLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRS-HALLPRLLRADRSPLSA 485
           L+ LIQ++RRR R  G    T+GF ++++PEEL G  +   S +  L    R        
Sbjct: 408 LVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFIN 467

Query: 486 RRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPY 545
            R+V  R  L PG Y++VPST     + DF +RVFSE++     +DD I A+L+      
Sbjct: 468 LREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISE 527

Query: 546 LPLELGLEQLFQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCE---QLLQ 602
             ++ G  +LF +LAGE+ E++A +LQ +L   L  A+          + TC+    +L 
Sbjct: 528 DDIDDGFRRLFAQLAGEDAEISAFELQTILRRVL--AKRQDIKSDGFSIETCKIMVDMLD 585

Query: 603 CFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQ 662
             G G+ L L  F  LW  + ++Q I+ + D D SGTMNSYE+R AL  AGF +  QL Q
Sbjct: 586 SDGSGK-LGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQ 644

Query: 663 TLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWM 713
            + +R+ D +L +DF+ FV C+  L  +F    Q      G I L    W+
Sbjct: 645 VIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  549 bits (1415), Expect = e-156
 Identities = 302/705 (42%), Positives = 419/705 (59%), Gaps = 39/705 (5%)

Query: 27  FRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPK 86
           + GQ YE +R  CL SG LFRD  FP  P +LGY  LGP+S K  G+KW RP E  + P+
Sbjct: 37  YLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQ 96

Query: 87  FICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQF 146
           FI +  +RTD+CQG+LG+CW LAA ASLTL   LL RVVP GQ FQ+GYAG+FHFQLWQF
Sbjct: 97  FIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQF 156

Query: 147 GRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVD 206
           G W+DVVVDD LP+++GKL+FV S + NEFW+ LLEKAYAK++GSYE + GG  +E F D
Sbjct: 157 GEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFED 216

Query: 207 FTGGVGEVLYLRQNSMGLFSALRHALAKESLVGA----TALSDRGEYRTEEGLVKGHAYS 262
           FTGGV E   LR+    L+  +  AL + SL+G     +++ D  E  T + LVKGHAYS
Sbjct: 217 FTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDM-EAITFKKLVKGHAYS 275

Query: 263 ITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVKKEDGEFW 322
           +TG  +V      V L+R+RNPWG VEWTGAWSDS   W+ +    RD L VK EDGEFW
Sbjct: 276 VTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFW 335

Query: 323 MELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTN 382
           M  RDF+  F  ++IC+L+P+ L  S     W+   ++G W RG  +GG +    TFW N
Sbjct: 336 MSFRDFMREFTRLEICNLTPDAL-KSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVN 394

Query: 383 PQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKG 442
           PQF++ L E D+ DD                    G R   C+ +L+L+Q++RRR R  G
Sbjct: 395 PQFKIRLDETDDPDD-------------------YGDRESGCSFVLALMQKHRRRERRFG 435

Query: 443 LTYLTVGFHVFQIPEELLGLWDSPRSHA----LLPRLLRADRSPLSARRDVTRRCCLRPG 498
               T+GF V+++P EL+G    P  H      L    RA        R+V+ R  L PG
Sbjct: 436 RDMETIGFAVYEVPPELVG---QPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPG 492

Query: 499 HYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQG-PYLPLELGLEQLFQ 557
            Y+VVPST     E DF LR FSE+    VE+DD I A+L   Q      ++   + LF+
Sbjct: 493 EYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFR 552

Query: 558 ELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQLLQCF---GHGQSLALHH 614
           +LAGE+ E++  +L+ +L+  +  ++      +   L +C  ++      G+G+ L L  
Sbjct: 553 QLAGEDMEISVKELRTILNRII--SKHKDLRTKGFSLESCRSMVNLMDRDGNGK-LGLVE 609

Query: 615 FQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLR 674
           F  LW  +  + +IF KFD D SG+M++YE+R+A+ +AGF LN +L + + +RY +  L 
Sbjct: 610 FNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLA 669

Query: 675 VDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719
           VDF+ FV C+  L  +F          +GV+     +W+++  F+
Sbjct: 670 VDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  535 bits (1378), Expect = e-152
 Identities = 304/728 (41%), Positives = 432/728 (59%), Gaps = 45/728 (6%)

Query: 1   MASSSGRVTIQLVDEEAGVGAGRLQL-FRGQSYEAIRAACLDSGILFRDPYFPAGPDALG 59
           MA+ +  V+ Q    + G+G+ +  L + GQ ++ +R  CLDSG+LF+DP FPA P ALG
Sbjct: 1   MAAQAAGVSRQRAATQ-GLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALG 59

Query: 60  YDQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPR 119
           Y  LGP S + +G+ W RP E C  P+FI    +RTD+CQG LG+CW LAA ASLTL   
Sbjct: 60  YKDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEE 119

Query: 120 LLRRVVPPGQDFQHGYAGVFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAP 179
           LL RVVP  QDFQ  YAG+FHFQ WQ+G W++VV+DDRLP + G+L+F+ SEQ NEFW+ 
Sbjct: 120 LLYRVVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSA 179

Query: 180 LLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVG 239
           LLEKAYAKL+G YE + GG   E F DFTGG+ E   L++    L+  +R AL   SL+G
Sbjct: 180 LLEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLG 239

Query: 240 AT---ALSDRGEYRTEEGLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSD 296
            +   + +   E  T + LVK HAYS+TG  +V       +L+RLRNPWG VEW+GAWSD
Sbjct: 240 CSIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSD 299

Query: 297 SCPRWDTLPTECRDALLVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHV 356
             P W+ +    ++ L  K EDGEFWM L DF+  F  ++IC+LSP+ L  S E   W++
Sbjct: 300 DAPEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLS-SEEVHKWNL 358

Query: 357 HTFQGRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPA 416
             F G W RG  +GG Q    T+WTNPQF++ L    +E DED+E   G           
Sbjct: 359 VLFNGHWTRGSTAGGCQNYPATYWTNPQFKIRL----DEVDEDQEESIG----------- 403

Query: 417 RGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRSH-ALLPRL 475
                P CTVLL L+Q+NRR  +  G   L++G+ V+Q+P+EL    D+       L   
Sbjct: 404 ----EPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQ 459

Query: 476 LRADRSPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVIS 535
             A  S     R+V+ R  L PG YLVVPST     + +F LRVFSE++  A+EI DV++
Sbjct: 460 PSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVA 519

Query: 536 ADLQSLQGPYLPLELGLEQ-------LFQELAGEEEELNASQLQALLSIALEPARAHTST 588
            +      PY P    ++Q       LF++LAG++ E+ A+ L+ LL+ A   ++     
Sbjct: 520 GN------PYEPHPSEVDQEDDQFRRLFEKLAGKDSEITANALKILLNEAF--SKRTDIK 571

Query: 589 PREIGLRTCEQ---LLQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYEL 645
                + TC +   LL   G G +L    F+ LW  + ++  I+ + D + SGT++++E+
Sbjct: 572 FDGFNINTCREMISLLDSNGTG-TLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEM 630

Query: 646 RLALNAAGFHLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVI 705
           R AL  AGF LN+Q+ QT+  RY  S+L ++F+ FV+C+  L  +F   S   +  +G++
Sbjct: 631 RTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMV 690

Query: 706 CLTHRQWM 713
            L+  +W+
Sbjct: 691 QLSLAEWL 698


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  528 bits (1361), Expect = e-150
 Identities = 291/708 (41%), Positives = 416/708 (58%), Gaps = 33/708 (4%)

Query: 18  GVGA-GRLQLFRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWM 76
           GVG     Q F  QS+E +RAACL  G LF DP FPA P +LG+  LGP+S+  + + W 
Sbjct: 51  GVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQ 110

Query: 77  RPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYA 136
           RP +    P FI + +S TD+CQG LG+CW LAA  SLT  P+LL RVVP GQ F+  YA
Sbjct: 111 RPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYA 170

Query: 137 GVFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMR 196
           G+FHFQ+WQFG+W++VVVDDRLP +  KL+FV S +R+EFW+ LLEKAYAKL GSYE + 
Sbjct: 171 GIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALS 230

Query: 197 GGHMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGAT--ALSDRG-EYRTEE 253
           GG   E   DFTGGV +   L++    L   LR A+ + SL+G +    SD   E  T++
Sbjct: 231 GGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDK 290

Query: 254 GLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALL 313
            LV+GHAYS+TG   V        L+R+RNPWG +EW GAWSDS   W+ + ++ +  LL
Sbjct: 291 MLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLL 350

Query: 314 VKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQ 373
            K EDGEFWM  +DFL +F  ++IC+L+P+ L    +   WH   ++G W RG ++GG +
Sbjct: 351 HKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYK-SYWHTTFYEGSWRRGSSAGGCR 409

Query: 374 PNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQR 433
            +  TFWTNPQF+++L E D+ +D+ E                  G    CT L++L+Q+
Sbjct: 410 NHPGTFWTNPQFKISLPEGDDPEDDAE------------------GNVVVCTCLVALMQK 451

Query: 434 NRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRSHALLPRLLRADRSPL-SARRDVTRR 492
           N R  R +G    T+GF ++ +P+E   + D         +      S + +  R+V+ +
Sbjct: 452 NWRHARQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQ 511

Query: 493 CCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISAD-LQSLQGPYLPLELG 551
             L PG Y+++PST     +ADF LRVF+E+   + E+D+V  A+ LQ  +     ++  
Sbjct: 512 LRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQD 571

Query: 552 LEQLFQELAGEEEELNASQLQALLS-IALEPARAHTSTPREIGLRTCE---QLLQCFGHG 607
              LF+ +AGE +E+   +LQ LL+ +A++     T   +  GL  C     L+   G G
Sbjct: 572 FLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKT---KGFGLDACRCMINLMDKDGSG 628

Query: 608 QSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSR 667
           + L L  F+ LW  L +W  IF + D+D SGT+NSYE+RL +  AG  LNN++ Q L +R
Sbjct: 629 K-LGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVAR 687

Query: 668 YRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEV 715
           Y D  L +DF+ F+SC   L  +F           G ICL+  QW+++
Sbjct: 688 YADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQM 735


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score =  508 bits (1308), Expect = e-144
 Identities = 275/701 (39%), Positives = 402/701 (57%), Gaps = 41/701 (5%)

Query: 30  QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFIC 89
           +++E +   CL+  +L+ DP FP    +L Y Q  P         W RP E C  P+FI 
Sbjct: 59  KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFII 113

Query: 90  EDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFGRW 149
           +  +RTD+CQG LG+CWFLAA A LTL   LL RV+P  Q F   YAG+FHFQ W++G W
Sbjct: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173

Query: 150 MDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTG 209
           +DVV+DD LP    +L+F +S  RNEFW+ LLEKAYAKLHGSYE ++GG+  EA  DFTG
Sbjct: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233

Query: 210 GVGEVLYLRQNSMGLFSALRHALAKESLVGA---TALSDRGEYRTEEGLVKGHAYSITGT 266
           GV E   +R     ++  ++ A+ + SL+G    T +  + E R   GLV+GHAYS+TG 
Sbjct: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGL 293

Query: 267 HKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVK-KEDGEFWMEL 325
            +V     KV+L+RLRNPWG VEW G+WSD    W  +  + +  L  +  EDGEFWM  
Sbjct: 294 DEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSY 353

Query: 326 RDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQF 385
            DF+ HF  ++IC+L+ + L  S +   W V   +GRWVRG ++GG +   +TFWTNPQ+
Sbjct: 354 EDFIYHFTKLEICNLTADAL-QSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQY 412

Query: 386 RLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTY 445
           RL LLE D++ D+ E                       C+ L++L+Q+NRR+ R  G + 
Sbjct: 413 RLKLLEEDDDPDDSE---------------------VICSFLVALMQKNRRKDRKLGASL 451

Query: 446 LTVGFHVFQIPEELLGLWDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPS 505
            T+GF ++++P+E+ G     +    L    +A        R+V++R  L P  Y++VPS
Sbjct: 452 FTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPS 511

Query: 506 TAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLPLELGLEQ----LFQELAG 561
           T     E +F LRVFSE+R+ + E+++ IS D    Q      E   +Q    +F+++AG
Sbjct: 512 TYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAG 571

Query: 562 EEEELNASQLQALLSIAL---EPARAHTSTPREIGLRTCEQLLQCFGHGQSLALHHFQQL 618
           ++ E+ A +L+ +L+  +   +  + H  T      R+   L+   G G+ L L  F  L
Sbjct: 572 DDMEICADELKKVLNTVVNKHKDLKTHGFTLE--SCRSMIALMDTDGSGK-LNLQEFHHL 628

Query: 619 WGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRVDFE 678
           W  +  WQ IF  +D D SGT+NSYE+R A+N AGFHLNNQL   +T RY D  + +DF+
Sbjct: 629 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 688

Query: 679 RFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719
            F+ C   L  +F         G+G+I L   +W+++  ++
Sbjct: 689 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  487 bits (1254), Expect = e-137
 Identities = 266/642 (41%), Positives = 373/642 (58%), Gaps = 34/642 (5%)

Query: 80  EFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVF 139
           E CA+P+FI    +RTD+CQG+LG+CW LAA ASLTL   +L RVVP  Q FQ  YAG+F
Sbjct: 2   EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61

Query: 140 HFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGH 199
           HFQ WQ+G W++VVVDDRLP ++G+L+FV S + +EFW+ LLEKAYAK++G YE + GG 
Sbjct: 62  HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121

Query: 200 MNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGA----TALSDRGEYRTEEGL 255
             E F DFTGG+ E   L++    LF  ++ AL K SL+G     T+ +D  E  T + L
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAAD-SEAITFQKL 180

Query: 256 VKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVK 315
           VKGHAYS+TG  +V    +  +L+R+RNPWG VEWTG W+D+CP W+T+  E R+ L  +
Sbjct: 181 VKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR 240

Query: 316 KEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPN 375
            EDGEFWM   DFL H+  ++IC+L+P+ L  S     W +    G W RG  +GG +  
Sbjct: 241 HEDGEFWMSFSDFLRHYSRLEICNLTPDTL-TSDTYKKWKLTKMDGNWRRGSTAGGCRNY 299

Query: 376 AETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNR 435
             TFW NPQ+ + L E DE++++ E G                     CT L+ LIQ++R
Sbjct: 300 PNTFWMNPQYLIKLEEEDEDEEDGESG---------------------CTFLVGLIQKHR 338

Query: 436 RRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRS-HALLPRLLRADRSPLSARRDVTRRCC 494
           RR R  G    T+GF ++++PEEL G  +   S +  L    R         R+V  R  
Sbjct: 339 RRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFK 398

Query: 495 LRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLPLELGLEQ 554
           L PG Y++VPST     + DF +RVFSE++     +DD I A+L+        ++ G  +
Sbjct: 399 LPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRR 458

Query: 555 LFQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCE---QLLQCFGHGQSLA 611
           LF +LAGE+ E++A +LQ +L   L  A+          + TC+    +L   G G+ L 
Sbjct: 459 LFAQLAGEDAEISAFELQTILRRVL--AKRQDIKSDGFSIETCKIMVDMLDSDGSGK-LG 515

Query: 612 LHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDS 671
           L  F  LW  + ++Q I+ + D D SGTMNSYE+R AL  AGF +  QL Q + +R+ D 
Sbjct: 516 LKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADD 575

Query: 672 RLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWM 713
           +L +DF+ FV C+  L  +F    Q      G I L    W+
Sbjct: 576 QLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 617


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score =  487 bits (1253), Expect = e-137
 Identities = 273/673 (40%), Positives = 383/673 (56%), Gaps = 54/673 (8%)

Query: 29  GQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAK-GVKWMRPHEFCAEPKF 87
           GQS+E +R  CL  G LF D  FPA   +L Y      SE+ +    W RP E    P+F
Sbjct: 26  GQSFEQMRQECLQRGTLFEDADFPASNSSLFY------SERPQIPFVWKRPGEIVKNPEF 79

Query: 88  ICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFG 147
           I    +RTD+CQG LG+CW LAA ASLTL  + L RV+P  Q F  GYAG+FHFQ WQ  
Sbjct: 80  ILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHS 139

Query: 148 RWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDF 207
            W+DVV+DDRLP    +L+F+ S   NEFW+ LLEKAYAKL+GSYE ++GG   EA  DF
Sbjct: 140 EWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDF 199

Query: 208 TGGVGEVLYLRQNSMGLFSALRHALAKESLVGA---TALSDRGEYRTEEGLVKGHAYSIT 264
           TGGV E    ++     +  L  AL + SL+G    T  +   E RT  GL+KGHAYS+T
Sbjct: 200 TGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVT 259

Query: 265 GTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTL-PTECRDALLVKKEDGEFWM 323
           G  +V     ++ L+R+RNPWG VEW G+WSDS P W ++ P E +       +DGEFWM
Sbjct: 260 GIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWM 319

Query: 324 ELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNP 383
             +DF  HFD V+IC+L+P+ L        W V   QG WVRG  +GG +   +TFWTNP
Sbjct: 320 AFKDFKAHFDKVEICNLTPDAL-EEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNP 378

Query: 384 QFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGL 443
           Q +L+L E DE  +E                         C+ L++L+Q++RR+L+  G 
Sbjct: 379 QIKLSLTEKDEGQEE-------------------------CSFLVALMQKDRRKLKRFGA 413

Query: 444 TYLTVGFHVFQIPEELLGL-WDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLV 502
             LT+G+ +++ P++   L  D  R HA      RA        R+V+ R  L PG Y++
Sbjct: 414 NVLTIGYAIYECPDKDEHLNKDFFRYHA-----SRARSKTFINLREVSDRFKLPPGEYIL 468

Query: 503 VPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLP-----LELGLEQLFQ 557
           +PST     EADF LR+FSE++    ++D  +  DL     P  P      E     LF+
Sbjct: 469 IPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFE 528

Query: 558 ELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCE---QLLQCFGHGQSLALHH 614
           ++AGE+ E+ A +L+ +L+  L+  +      +++ L +C+    L+   G+G+ L    
Sbjct: 529 QVAGEDMEVTAEELEYVLNAVLQ--KKKDIKFKKLSLISCKNIISLMDTSGNGK-LEFDE 585

Query: 615 FQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLR 674
           F+  W  L +W  +F +FD D SGTM++YELR AL AAGF L++ L Q +  RY D  L+
Sbjct: 586 FKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQ 645

Query: 675 VDFERFVSCVAHL 687
           +DF+ F++C+  L
Sbjct: 646 LDFDDFLNCLVRL 658


>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score =  480 bits (1236), Expect = e-135
 Identities = 279/793 (35%), Positives = 408/793 (51%), Gaps = 133/793 (16%)

Query: 30  QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFIC 89
           +++E +   CL+  +L+ DP FP    +L Y Q  P         W RP E C  P+FI 
Sbjct: 59  KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFII 113

Query: 90  EDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFGRW 149
           +  +RTD+CQG LG+CWFLAA A LTL   LL RV+P  Q F   YAG+FHFQ W++G W
Sbjct: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173

Query: 150 MDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTG 209
           +DVV+DD LP    +L+F +S  RNEFW+ LLEKAYAKLHGSYE ++GG+  EA  DFTG
Sbjct: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233

Query: 210 GVGEVLYLRQNSMGLFSALRHALAKESLVGATA--------------------------- 242
           GV E   +R     ++  ++ A+ + SL+G +                            
Sbjct: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293

Query: 243 ----------LSDRG--------------EYRTEEGLVKGHAYSITGTHKVFLGFTKVRL 278
                     L  RG              E R   GLV+GHAYS+TG  +V     KV+L
Sbjct: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353

Query: 279 LRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVK-KEDGEFWMELRDFLLHFDTVQI 337
           +RLRNPWG VEW G+WSD    W  +  + +  L  +  EDGEFWM   DF+ HF  ++I
Sbjct: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413

Query: 338 CSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDD 397
           C+L+ + L  S +   W V   +GRWVRG ++GG +   +TFWTNPQ+RL LLE D++ D
Sbjct: 414 CNLTADAL-QSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPD 472

Query: 398 EDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPE 457
           + E                       C+ L++L+Q+NRR+ R  G +  T+GF ++++P+
Sbjct: 473 DSE---------------------VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPK 511

Query: 458 ELLGLWDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTL 517
           E+ G     +    L    +A        R+V++R  L P  Y++VPST     E +F L
Sbjct: 512 EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFIL 571

Query: 518 RVFSERRHTAVEIDDVISADLQSLQGPYLPL-----------ELGLEQ------------ 554
           RVFSE+R+ + E+++ IS D    +    P+           ELG++Q            
Sbjct: 572 RVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPD 631

Query: 555 -------------------------LFQELAGEEEELNASQLQALLSIAL---EPARAHT 586
                                    +F+++AG++ E+ A +L+ +L+  +   +  + H 
Sbjct: 632 KQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHG 691

Query: 587 STPREIGLRTCEQLLQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELR 646
            T      R+   L+   G G+ L L  F  LW  +  WQ IF  +D D SGT+NSYE+R
Sbjct: 692 FTLE--SCRSMIALMDTDGSGK-LNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMR 748

Query: 647 LALNAAGFHLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVIC 706
            A+N AGFHLNNQL   +T RY D  + +DF+ F+ C   L  +F         G+G+I 
Sbjct: 749 NAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIK 808

Query: 707 LTHRQWMEVATFS 719
           L   +W+++  ++
Sbjct: 809 LNVLEWLQLTMYA 821


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score =  478 bits (1230), Expect = e-135
 Identities = 278/787 (35%), Positives = 406/787 (51%), Gaps = 127/787 (16%)

Query: 30  QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFIC 89
           +++E +   CL+  +L+ DP FP    +L Y Q  P         W RP E C  P+FI 
Sbjct: 59  KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFII 113

Query: 90  EDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFGRW 149
           +  +RTD+CQG LG+CWFLAA A LTL   LL RV+P  Q F   YAG+FHFQ W++G W
Sbjct: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173

Query: 150 MDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTG 209
           +DVV+DD LP    +L+F +S  RNEFW+ LLEKAYAKLHGSYE ++GG+  EA  DFTG
Sbjct: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233

Query: 210 GVGEVLYLRQNSMGLFSALRHALAKESLVGATA--------------------------- 242
           GV E   +R     ++  ++ A+ + SL+G +                            
Sbjct: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293

Query: 243 ----------LSDRG--------------EYRTEEGLVKGHAYSITGTHKVFLGFTKVRL 278
                     L  RG              E R   GLV+GHAYS+TG  +V     KV+L
Sbjct: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353

Query: 279 LRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVK-KEDGEFWMELRDFLLHFDTVQI 337
           +RLRNPWG VEW G+WSD    W  +  + +  L  +  EDGEFWM   DF+ HF  ++I
Sbjct: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413

Query: 338 CSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDD 397
           C+L+ + L  S +   W V   +GRWVRG ++GG +   +TFWTNPQ+RL LLE D++ D
Sbjct: 414 CNLTADAL-QSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPD 472

Query: 398 EDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPE 457
           + E                       C+ L++L+Q+NRR+ R  G +  T+GF ++++P+
Sbjct: 473 DSE---------------------VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPK 511

Query: 458 ELLGLWDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTL 517
           E+ G     +    L    +A        R+V++R  L P  Y++VPST     E +F L
Sbjct: 512 EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFIL 571

Query: 518 RVFSERRHTAVEIDDVISAD-----LQSLQGPYLPLELGLEQ------------------ 554
           RVFSE+R+ + E+++ IS D     +          ELG++Q                  
Sbjct: 572 RVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSP 631

Query: 555 -------------------LFQELAGEEEELNASQLQALLSIAL---EPARAHTSTPREI 592
                              +F+++AG++ E+ A +L+ +L+  +   +  + H  T    
Sbjct: 632 QPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLE-- 689

Query: 593 GLRTCEQLLQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAA 652
             R+   L+   G G+ L L  F  LW  +  WQ IF  +D D SGT+NSYE+R A+N A
Sbjct: 690 SCRSMIALMDTDGSGK-LNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDA 748

Query: 653 GFHLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQW 712
           GFHLNNQL   +T RY D  + +DF+ F+ C   L  +F         G+G+I L   +W
Sbjct: 749 GFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEW 808

Query: 713 MEVATFS 719
           +++  ++
Sbjct: 809 LQLTMYA 815


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score =  455 bits (1170), Expect = e-128
 Identities = 263/672 (39%), Positives = 369/672 (54%), Gaps = 78/672 (11%)

Query: 29  GQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAK-GVKWMRPHEFCAEPKF 87
           GQS+E +R  CL  G LF D  FPA   +L Y      SE+ +    W RP E    P+F
Sbjct: 26  GQSFEQMRQECLQRGTLFEDADFPASNSSLFY------SERPQIPFVWKRPGEIVKNPEF 79

Query: 88  ICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFG 147
           I    +RTD+CQG LG+CW LAA ASLTL  + L RV+P  Q F  GYAG+FHFQ WQ  
Sbjct: 80  ILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHS 139

Query: 148 RWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDF 207
            W+DVV+DDRLP    +L+F+ S   NEFW+ LLEKAYAKL+GSYE ++GG   EA  DF
Sbjct: 140 EWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDF 199

Query: 208 TGGVGEVLYLRQNSMGLFSALRHALAKESLVGA---TALSDRGEYRTEEGLVKGHAYSIT 264
           TGGV E    ++     +  L  AL + SL+G    T  +   E RT  GL+KGHAYS+T
Sbjct: 200 TGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVT 259

Query: 265 GTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVKKEDGEFWME 324
           G  +V     ++ L+R+RNPWG VEW G+WSD                          M 
Sbjct: 260 GIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MA 294

Query: 325 LRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQ 384
            +DF  HFD V+IC+L+P+ L        W V   QG WVRG  +GG +   +TFWTNPQ
Sbjct: 295 FKDFKAHFDKVEICNLTPDAL-EEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQ 353

Query: 385 FRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLT 444
            +L+L E DE  +E                         C+ L++L+Q++RR+L+  G  
Sbjct: 354 IKLSLTEKDEGQEE-------------------------CSFLVALMQKDRRKLKRFGAN 388

Query: 445 YLTVGFHVFQIPEELLGL-WDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLVV 503
            LT+G+ +++ P++   L  D  R HA      RA        R+V+ R  L PG Y+++
Sbjct: 389 VLTIGYAIYECPDKDEHLNKDFFRYHA-----SRARSKTFINLREVSDRFKLPPGEYILI 443

Query: 504 PSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLP-----LELGLEQLFQE 558
           PST     EADF LR+FSE++    ++D  +  DL     P  P      E     LF++
Sbjct: 444 PSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQ 503

Query: 559 LAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCE---QLLQCFGHGQSLALHHF 615
           +AGE+ E+ A +L+ +L+  L+  +      +++ L +C+    L+   G+G+ L    F
Sbjct: 504 VAGEDMEVTAEELEYVLNAVLQ--KKKDIKFKKLSLISCKNIISLMDTSGNGK-LEFDEF 560

Query: 616 QQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRV 675
           +  W  L +W  +F +FD D SGTM++YELR AL AAGF L++ L Q +  RY D  L++
Sbjct: 561 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 620

Query: 676 DFERFVSCVAHL 687
           DF+ F++C+  L
Sbjct: 621 DFDDFLNCLVRL 632


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score =  454 bits (1168), Expect = e-127
 Identities = 263/738 (35%), Positives = 384/738 (52%), Gaps = 122/738 (16%)

Query: 79  HEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGV 138
           +E C  P+FI +  +RTD+CQG LG+CWFLAA A LTL   LL RV+P  Q F   YAG+
Sbjct: 16  NEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGI 75

Query: 139 FHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGG 198
           FHFQ W++G W+DVV+DD LP    +L+F +S  RNEFW+ LLEKAYAKLHGSYE ++GG
Sbjct: 76  FHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGG 135

Query: 199 HMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGATA---------------- 242
           +  EA  DFTGGV E   +R     ++  ++ A+ + SL+G +                 
Sbjct: 136 NTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLN 195

Query: 243 ---------------------LSDRG--------------EYRTEEGLVKGHAYSITGTH 267
                                L  RG              E R   GLV+GHAYS+TG  
Sbjct: 196 MGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLD 255

Query: 268 KVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVK-KEDGEFWMELR 326
           +V     KV+L+RLRNPWG VEW G+WSD    W  +  + +  L  +  EDGEFWM   
Sbjct: 256 EVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYE 315

Query: 327 DFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQFR 386
           DF+ HF  ++IC+L+ + L  S +   W V   +GRWVRG ++GG +   +TFWTNPQ+R
Sbjct: 316 DFIYHFTKLEICNLTADAL-QSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYR 374

Query: 387 LTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYL 446
           L LLE D++ D+ E                       C+ L++L+Q+NRR+ R  G +  
Sbjct: 375 LKLLEEDDDPDDSE---------------------VICSFLVALMQKNRRKDRKLGASLF 413

Query: 447 TVGFHVFQIPEELLGLWDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPST 506
           T+GF ++++P+E+ G     +    L    +A        R+V++R  L P  Y++VPST
Sbjct: 414 TIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPST 473

Query: 507 AHAGDEADFTLRVFSERRHTAVEIDDVISAD-----LQSLQGPYLPLELGLEQ------- 554
                E +F LRVFSE+R+ + E+++ IS D     +          ELG++Q       
Sbjct: 474 YEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKG 533

Query: 555 ------------------------------LFQELAGEEEELNASQLQALLSIAL---EP 581
                                         +F+++AG++ E+ A +L+ +L+  +   + 
Sbjct: 534 KTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKD 593

Query: 582 ARAHTSTPREIGLRTCEQLLQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMN 641
            + H  T      R+   L+   G G+ L L  F  LW  +  WQ IF  +D D SGT+N
Sbjct: 594 LKTHGFTLE--SCRSMIALMDTDGSGK-LNLQEFHHLWNKIKAWQKIFKHYDTDQSGTIN 650

Query: 642 SYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGG 701
           SYE+R A+N AGFHLNNQL   +T RY D  + +DF+ F+ C   L  +F         G
Sbjct: 651 SYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDG 710

Query: 702 EGVICLTHRQWMEVATFS 719
           +G+I L   +W+++  ++
Sbjct: 711 DGIIKLNVLEWLQLTMYA 728


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  383 bits (983), Expect = e-106
 Identities = 257/707 (36%), Positives = 367/707 (51%), Gaps = 67/707 (9%)

Query: 30  QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFIC 89
           Q +EA+ A CL +G LF D  FPA   ++G   L    +    ++W RP E  + P+F  
Sbjct: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLL--QKLPPRLQWKRPPELHSNPQFYF 85

Query: 90  EDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFGRW 149
               R D+CQG +G+CWFLAA  +L L+  +L RVVP  Q F   YAG+F F  W +G W
Sbjct: 86  AKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNW 145

Query: 150 MDVVVDDRLPVRE-GKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFT 208
           + VV+DDRLPV E G+L+FV S  +N FW  LLEKAYAKL GSYE ++ G ++EA VDFT
Sbjct: 146 VPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205

Query: 209 GGVGEVLYLRQNSMGLFSALRHALAKESLVGATALSDRGEYRTEEGLVKGHAYSITGTHK 268
           GGV   + L +    L+  L  A    +L+G    S  GE   E GLV+GHAY++TG  K
Sbjct: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHS--GEKILENGLVEGHAYTLTGIRK 263

Query: 269 VFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVKKEDGEFWMELRDF 328
           V        L++LRNPWG VEW G WSDS  +W+ L  + +  LL K  DGEFWM L+DF
Sbjct: 264 VTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDF 323

Query: 329 LLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGS-QPNAETFWTNPQFRL 387
             HF  + IC L+P +L        W     +GRW +   +GG  Q   +TFW NPQF L
Sbjct: 324 KTHFVLLVICKLTPGLLS-QEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLL 382

Query: 388 TLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYLT 447
           ++  P+E             G    R          C+VL+SL+Q+ R R R K    L 
Sbjct: 383 SVWRPEE-------------GRRSLR---------PCSVLVSLLQKPRHRCR-KRKPLLA 419

Query: 448 VGFHVFQIPEELLGLWDSPRSHALLPRLLRADRSPLS------ARRDVTRRCCLRPGHYL 501
           +GF+++++ +      D  R    LP       +PLS        ++V++  CL PG YL
Sbjct: 420 IGFYLYRMNK----YHDDQRR---LPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYL 472

Query: 502 VVPSTAHAGDEADFTLRVFSERRHTAVEIDD----VISADLQSLQGPYLPLELGLEQLFQ 557
           +VP    A  +++F LRVFS R+H   EI      V S +++             ++ F 
Sbjct: 473 IVPCILEAHQKSEFVLRVFS-RKHIFYEIGSNSGVVFSKEIEDQNERQ-------DEFFT 524

Query: 558 ELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQLLQCFGHGQS--LALHHF 615
           +   +  E+NA QLQ LL+     +    S      L  C+ +L       S  +++  F
Sbjct: 525 KFFEKHPEINAVQLQNLLNQMTWSSLG--SRQPFFSLEACQGILALLDLNASGTMSIQEF 582

Query: 616 QQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRV 675
           + LW  L   Q +F+K D   SG +N  +L  A+  AG  L++ + Q +  RY   RL++
Sbjct: 583 RDLWKQLKLSQKVFHKQDRG-SGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQM 641

Query: 676 DFERFVSC---VAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719
           DF  F+     V ++  +F + +Q    G+G I L   +WM +A +S
Sbjct: 642 DFVSFIHLMLRVENMEDVFQNLTQ---DGKG-IYLQKPEWMMMALYS 684


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  270 bits (691), Expect = 3e-72
 Identities = 172/531 (32%), Positives = 255/531 (48%), Gaps = 83/531 (15%)

Query: 27  FRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQL-GPDSEKAKGVKWMRPHEFCAEP 85
           +  Q+Y A+R  C    +LF DP FPA  D+L Y    GP       V+W RP   C +P
Sbjct: 8   YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGP------AVRWKRPKGICEDP 61

Query: 86  KFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQ------HGYAGVF 139
           +   + +S  D+ QG +GNCWF+AA +SL     L ++V+P  ++ +      + YAG+F
Sbjct: 62  RLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIF 121

Query: 140 HFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGH 199
           HF  W+FG W+DVV+DDRLP    +L++  S  RNEFW  L+EKAYAKL G Y+ + GG+
Sbjct: 122 HFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGN 181

Query: 200 MNEAFVDFTGGVGEVLYLRQNSMG--------LFSALRHALAKESLVGATALSDRG---E 248
             +A VDFTGGV E + L +            LF  +    ++  L+ A+  +      E
Sbjct: 182 TADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADME 241

Query: 249 YRTEEGLVKGHAYSITGTHKVFLGF--------TKVRLLRLRNPWGCVEWTGAWSDSCPR 300
            R   GLVKGHAY++T   KV LG          K+ ++RLRNPWG  EW G WSD+   
Sbjct: 242 ARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEE 301

Query: 301 WDTLPTECRDAL-LVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEG--GGWHVH 357
           W  +    R+ + +  ++DGEFWM   D   +F  +  C     V+  S       W   
Sbjct: 302 WQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKC----RVINTSHLSIHKTWEEA 357

Query: 358 TFQGRWV-----RGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGA 412
              G W      R    GG   + +TF+ NPQ+   + +P++E                 
Sbjct: 358 RLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDE----------------- 400

Query: 413 RGPARGGRTPKCTVLLSLIQRNRRRLRAKGL-TYLTVGFHVFQIPEELLGLWDSPRSHAL 471
                        VL+ + QR +R  R +G    L +GF ++++ E         R + +
Sbjct: 401 -------------VLICIQQRPKRSTRREGKGENLAIGFDIYKVEEN--------RQYRM 439

Query: 472 LPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSE 522
                +A  S     R V  R     G Y+++P+T   G   +F LRVF++
Sbjct: 440 HSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTD 490


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  268 bits (685), Expect = 1e-71
 Identities = 218/710 (30%), Positives = 329/710 (46%), Gaps = 73/710 (10%)

Query: 27  FRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCA-EP 85
           F+ Q +  +R  CL  G  F+D  FPA   ++G   L    ++   V W RP +     P
Sbjct: 16  FKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLL--QEKRLSNVIWKRPQDLPGGPP 73

Query: 86  KFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQ 145
            FI +D+SR D+ QG   +CWFLAA  SLT  P+  ++++   Q F H YAG+F F+ WQ
Sbjct: 74  HFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFWQ 132

Query: 146 FGRWMDVVVDDRLPVREGKLMFVRSEQRN-EFWAPLLEKAYAKLHGSYEVMRGGHMNEAF 204
            G+W++VV+DDRLPV+  K +FVR   +N EFW  LLEKAYAKL GSY  +  G + +A 
Sbjct: 133 CGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDAL 192

Query: 205 VDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGATALSDRGEYRT----EEGLVKGHA 260
           VD TGGV   ++L  + + L  A++ A    SL+  T  +  G   T    E GLV  HA
Sbjct: 193 VDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLI--TCATPSGPTDTAQAMENGLVSLHA 250

Query: 261 YSITGTHKVFLGFTKVRLLRLRNPWGC--VEWTGAWSDSCPRWDTLPTECRDALLVKKED 318
           Y++TG  ++        ++ L NPWG    EW G WSD    W+      +  L  K+ED
Sbjct: 251 YTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRED 310

Query: 319 GEFWMELRDFLLHFDTVQICSLSPEVLG-PSPEGGGWHVHTFQGRWVRGFNSGGSQPNAE 377
           GEFWM  +DF   F  + ICS  P  L   +    GW    F+ + + G  +GG + +A 
Sbjct: 311 GEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRNDA- 369

Query: 378 TFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRR 437
                 QF  ++ EP E                        G      V +++   N + 
Sbjct: 370 ------QFNFSVQEPME------------------------GTNVVVCVTVAVTPSNLKA 399

Query: 438 LRAKGLTYLTVGFHVFQIPEELLGLWDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRP 497
             AK      + F V     +       P   +     +++  +    RR+ T    L P
Sbjct: 400 EDAK----FPLDFQVILAGSQRFREKFPPVFFSSFRNTVQSSNNKF--RRNFTMTYHLSP 453

Query: 498 GHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLPLELGLEQ-LF 556
           G+Y+VV  T      A+F LR+F +      + D  +S+   +L+    P E G +Q +F
Sbjct: 454 GNYVVVAQTRR--KSAEFLLRIFLK----MPDSDRHLSSHF-NLRMKGSPSEHGSQQSIF 506

Query: 557 QELAGEEEELNASQLQALLSIALEPARAHTSTPREI-GLRTCEQL--LQCFGHGQSLALH 613
              A +  +++A+QLQ LL+  L      T  P ++  L  C  L  L        L   
Sbjct: 507 NRYAQQRLDIDATQLQGLLNQEL-----LTGPPGDMFSLDECRSLVALMELKVNGRLDQE 561

Query: 614 HFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALN----AAGFHLNNQLTQTLTSRYR 669
            F +LW  L+ +Q +F K  + + G + S +L  A+       G  ++ +L   +T RY 
Sbjct: 562 EFARLWKRLVHYQHVFQKV-QTSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYS 620

Query: 670 DSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719
           DS  RV F   V  +  L  +          G+G + LT  +WM +  ++
Sbjct: 621 DSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKG-LYLTEMEWMSLVMYN 669


>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score =  236 bits (603), Expect = 4e-62
 Identities = 177/541 (32%), Positives = 249/541 (46%), Gaps = 64/541 (11%)

Query: 45  LFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGN 104
           LFRD  FPA   +L  D   P ++  + + W RP E CA P+   +D     V QG LG+
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 105 CWFLAAAASLTLYPRLLRRVVPPGQDF--QHGYAGVFHFQLWQFGRWMDVVVDDRLPVRE 162
           CWFL A A+L     LL +V+PPGQ       Y G F  ++WQFGRW++V  DDRLP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 163 GKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLR---- 218
           G+L F R ++ + FW PLLEK YAK+HGSYE +  G + +A VD TGG+ E   L+    
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192

Query: 219 ----QNSMGLFS-----ALRHALAKESLVGATALSDRGEYRTEEGLVKGHAYSITGTHKV 269
               Q+  G +       L H L  + L+    LS R   R    L + HA+ ++   ++
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLH-LKDQCLISCCVLSPRAGARE---LGEFHAFIVSDLREL 248

Query: 270 -FLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVKKEDGEFWMELRDF 328
                  + LLR++NPWG   W G W +    W  +       LL + ++GEFW+E  +F
Sbjct: 249 QGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEF 308

Query: 329 LLHFDTVQI---CSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQF 385
           L  FD + +    + +  +     E    H     G WV+G ++GG + N+  F +NP+F
Sbjct: 309 LREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNS-GFPSNPKF 367

Query: 386 RLTLLEPDE------EDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLR 439
            L + EP E      +        W G  A    G +    +P                 
Sbjct: 368 WLRVSEPSEVYIAVLQRSRLHAADWAG-RARALVGDSHTSWSP---------------AS 411

Query: 440 AKGLTYLTVGFHVFQIPEELLGLWDSPRSHALLPRLLR----ADRSPLSARRDVTRRCCL 495
             G  Y  VG H          LW   +    LPR+L     A  +  +  R+V  RC L
Sbjct: 412 IPGKHYQAVGLH----------LWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCEL 461

Query: 496 RPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLPL-ELGLEQ 554
            PG+YL VPST       +F LRVFS  R   V +  + +    +  G  LP  E G  Q
Sbjct: 462 SPGYYLAVPSTFLKDAPGEFLLRVFSTGR---VSLSAIRAVAKNTTPGAALPAGEWGTVQ 518

Query: 555 L 555
           L
Sbjct: 519 L 519



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 51/199 (25%), Positives = 79/199 (39%), Gaps = 43/199 (21%)

Query: 346 GPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWG 405
           G +   G W     +G W  G  +GGS+ N  ++ TNP F  ++ E              
Sbjct: 506 GAALPAGEWGTVQLRGSWRVGQTAGGSR-NFASYPTNPCFPFSVPE-------------- 550

Query: 406 GWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDS 465
                        G  P+C V ++L Q      R     +  +GFH+FQ+PE        
Sbjct: 551 -------------GPGPRC-VRITLHQ----HCRPSDTEFHPIGFHIFQVPE-------G 585

Query: 466 PRSHALLPRLLR---ADRSPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSE 522
            RS    P LL+       P    ++V+R C L  G Y VVPST     E  FT+ + + 
Sbjct: 586 GRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATR 645

Query: 523 RRHTAVEIDDVISADLQSL 541
               ++   +++   LQ +
Sbjct: 646 IDRPSIHSQEMLGQFLQEV 664


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  231 bits (589), Expect = 2e-60
 Identities = 166/525 (31%), Positives = 244/525 (46%), Gaps = 56/525 (10%)

Query: 45  LFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGN 104
           LFRD  FPA   +L  D   P ++  + + W RP E CA P+   +D     V QG LG+
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 105 CWFLAAAASLTLYPRLLRRVVPPGQDF--QHGYAGVFHFQLWQFGRWMDVVVDDRLPVRE 162
           CWFL A A+L     LL +V+PPGQ       Y G F  ++WQFGRW++V  DDRLP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 163 GKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLR---- 218
           G+L F R ++ + FW PLLEK YAK+HGSYE +  G + +A VD TGG+ E   L+    
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192

Query: 219 ----QNSMGLFS-----ALRHALAKESLVGATALSDRGEYRTEEGLVKGHAYSITGTHKV 269
               Q+  G +       L H L  + L+    LS R   R    L + HA+ ++   ++
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLH-LKDQCLISCCVLSPRAGARE---LGEFHAFIVSDLREL 248

Query: 270 -FLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVKKEDGEFWMELRDF 328
                  + LLR++NPWG   W G W +    W  +       LL + ++GEFW+E  +F
Sbjct: 249 QGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEF 308

Query: 329 LLHFDTVQI---CSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQF 385
           L  FD + +    + +  +     E    H     G WV+G ++GG + N+  F +NP+F
Sbjct: 309 LREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNS-GFPSNPKF 367

Query: 386 RLTLLEPDE------EDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLR 439
            L + EP E      +        W G  A    G +    +P                 
Sbjct: 368 WLRVSEPSEVYIAVLQRSRLHAADWAG-RARALVGDSHTSWSP---------------AS 411

Query: 440 AKGLTYLTVGFHVFQIPEELLGLWDSPRSHALLPRLLR---ADRSPLSARRDVTRRCCLR 496
             G  Y  VG H++++PE         RS    P LL+       P    ++V+R C L 
Sbjct: 412 IPGKHYQAVGLHLWKVPE-------GGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLP 464

Query: 497 PGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSL 541
            G Y VVPST     E  FT+ + +     ++   +++   LQ +
Sbjct: 465 AGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEV 509


>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score =  229 bits (585), Expect = 5e-60
 Identities = 168/532 (31%), Positives = 248/532 (46%), Gaps = 80/532 (15%)

Query: 24  LQLFRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCA 83
           L+LF+ Q Y+ ++  C+    LF DP F    D+L Y++L P       V W RP + C 
Sbjct: 5   LKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK-----VVWKRPQDICD 59

Query: 84  EPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQ------HGYAG 137
           +P  I  ++S   + QG LG+   ++A + L +      + +P  ++ +        YAG
Sbjct: 60  DPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAG 119

Query: 138 VFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRG 197
           +FHF+ W FG W +VV+DD LP   G L+F  S   NEFW  LLEKAYAKL G YE + G
Sbjct: 120 IFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDG 179

Query: 198 GHMNEAFVDFTGGVGEVLYLR--------QNSMGLFSALRHALAKESLVGATALS---DR 246
             + +  VDFTG + E + ++        +    LF  L     K  L+  +  S   + 
Sbjct: 180 LTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEE 239

Query: 247 GEYRTEEGLVKGHAYSITGTHKVFLG--------FTKVRLLRLRNPWGCVEWTGAWSDSC 298
            E  T+ GL+KGH Y++T   K+ LG          KV ++RLRNP G  EW+G WS+  
Sbjct: 240 QEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEIS 299

Query: 299 PRWDTLPTECRDAL-LVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVH 357
             W  L    R  L LV  +DGEFWM L DF  +F  + +C         +P  G   + 
Sbjct: 300 EEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNV-----NNPIFGRKELE 354

Query: 358 TFQGRWVRGFN-----SGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGA 412
           +  G W    +     SGG   N +TF  NPQ+  T+ E   +                 
Sbjct: 355 SVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHK----------------- 397

Query: 413 RGPARGGRTPKCTVLLSLIQRNRRRLRAKGL--TYLTVGFHVFQIPEELLGLWDSPRSHA 470
                        V++SL Q++ R  R  G    Y+ +GF +F++      +    R H 
Sbjct: 398 -------------VIMSLQQKDLRTYRRMGRPDNYI-IGFELFKVE-----MNRKFRLHH 438

Query: 471 LLPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSE 522
           L  +  RA  S     R V     L+ G+Y++VP+    G  ++F LR+FSE
Sbjct: 439 LYIQ-ERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSE 489


>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score =  167 bits (423), Expect = 3e-41
 Identities = 114/335 (34%), Positives = 159/335 (47%), Gaps = 42/335 (12%)

Query: 32  YEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEF-CAEPK---- 86
           +E I A C ++ + F D  FP GP+++G+     DS + +  +W+RP E  C+  +    
Sbjct: 474 WENIVAFCRENNVSFVDDSFPPGPESVGFP--AGDSVQQRVRQWLRPQEINCSVFRDHRA 531

Query: 87  --FICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLW 144
              +   +  +D+ QG LGNCWFL+A A L   P L+ RV+        G    +  +L 
Sbjct: 532 TWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEG---AYQVRLC 588

Query: 145 QFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAF 204
           + G W  V+VDD LP  E   +     QR + W  L+EKA AKLHGSY  ++ G   E  
Sbjct: 589 KDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGL 648

Query: 205 VDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGATALSDR------------GEYRTE 252
              TG   E L L+ +S    +  R       L+ A  LS +            G  + +
Sbjct: 649 ATLTGAPCESLALQLSS----TNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVD 704

Query: 253 E------GLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPT 306
           +      GL   HAYSI     V       RLLRLRNPWG   W G+WSD  P W   P 
Sbjct: 705 DSAYESLGLRPRHAYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PG 757

Query: 307 ECRDALLVK-KEDGEFWMELRDFLLHFDTVQICSL 340
             R  L+     +G FWME  DF+ +FD+V IC +
Sbjct: 758 HLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICKV 792


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score =  135 bits (339), Expect = 2e-31
 Identities = 86/284 (30%), Positives = 138/284 (48%), Gaps = 54/284 (19%)

Query: 487 RDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYL 546
           R+V++R  L P  Y++VPST     E +F LRVFSE+R+ + E+++ IS D    +    
Sbjct: 29  REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK 88

Query: 547 PL-----------ELGLEQ-------------------------------------LFQE 558
           P+           ELG++Q                                     +F++
Sbjct: 89  PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 148

Query: 559 LAGEEEELNASQLQALLSIAL---EPARAHTSTPREIGLRTCEQLLQCFGHGQSLALHHF 615
           +AG++ E+ A +L+ +L+  +   +  + H  T      R+   L+   G G+ L L  F
Sbjct: 149 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESC--RSMIALMDTDGSGK-LNLQEF 205

Query: 616 QQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRV 675
             LW  +  WQ IF  +D D SGT+NSYE+R A+N AGFHLNNQL   +T RY D  + +
Sbjct: 206 HHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNI 265

Query: 676 DFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719
           DF+ F+ C   L  +F         G+G+I L   +W+++  ++
Sbjct: 266 DFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 309


>gi|27765080 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 49/125 (39%), Positives = 71/125 (56%), Gaps = 1/125 (0%)

Query: 595 RTCEQLLQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGF 654
           R+   L+   G G+ L L  F  LW  +  WQ IF  +D D SGT+NSYE+R A+N AGF
Sbjct: 33  RSMIALMDTDGSGK-LNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGF 91

Query: 655 HLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWME 714
           HLNNQL   +T RY D  + +DF+ F+ C   L  +F         G+G+I L   +W++
Sbjct: 92  HLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQ 151

Query: 715 VATFS 719
           +  ++
Sbjct: 152 LTMYA 156


>gi|27765078 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 49/125 (39%), Positives = 71/125 (56%), Gaps = 1/125 (0%)

Query: 595 RTCEQLLQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGF 654
           R+   L+   G G+ L L  F  LW  +  WQ IF  +D D SGT+NSYE+R A+N AGF
Sbjct: 33  RSMIALMDTDGSGK-LNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGF 91

Query: 655 HLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWME 714
           HLNNQL   +T RY D  + +DF+ F+ C   L  +F         G+G+I L   +W++
Sbjct: 92  HLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQ 151

Query: 715 VATFS 719
           +  ++
Sbjct: 152 LTMYA 156


>gi|4502565 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 4/168 (2%)

Query: 554 QLFQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQLLQCFGHGQS--LA 611
           +LF +LAG++ E++A++L  +L+  +   R         G+ TC  ++       +  L 
Sbjct: 103 RLFAQLAGDDMEVSATELMNILNKVV--TRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLG 160

Query: 612 LHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDS 671
              F+ LW  +  WQAI+ +FD D SGT+ S EL  A  AAGFHLN  L   +  RY D 
Sbjct: 161 FEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDE 220

Query: 672 RLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719
              +DF+ F+SC+  L  +F         G G I +  ++W+++  +S
Sbjct: 221 SGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 268


>gi|51599151 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 4/168 (2%)

Query: 554 QLFQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQLLQCFGHGQS--LA 611
           +LF +LAG++ E++A++L  +L+  +   R         G+ TC  ++       +  L 
Sbjct: 103 RLFAQLAGDDMEVSATELMNILNKVV--TRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLG 160

Query: 612 LHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDS 671
              F+ LW  +  WQAI+ +FD D SGT+ S EL  A  AAGFHLN  L   +  RY D 
Sbjct: 161 FEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDE 220

Query: 672 RLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719
              +DF+ F+SC+  L  +F         G G I +  ++W+++  +S
Sbjct: 221 SGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 268


>gi|14161692 calpain small subunit 2 [Homo sapiens]
          Length = 248

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 51/169 (30%), Positives = 87/169 (51%), Gaps = 6/169 (3%)

Query: 554 QLFQELAGEEEELNASQLQALLSIALEPARAHTSTPRE-IGLRTCEQLLQCFGHGQS--L 610
           Q F +LAG + E+ A+ L  +L+  L     H     +   L TC  ++       +  L
Sbjct: 83  QQFTQLAGPDMEVGATDLMNILNKVLSK---HKDLKTDGFSLDTCRSIVSVMDSDTTGKL 139

Query: 611 ALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRD 670
               F+ LW  + +WQ ++ ++D D SG++ S +LR AL AAGF LN QL Q +  RY +
Sbjct: 140 GFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYAN 199

Query: 671 SRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719
               +DF  F+SC+  L  +F          +G+I ++ ++W+++  +S
Sbjct: 200 EDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMYS 248


>gi|7656959 calpain 7 [Homo sapiens]
          Length = 813

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 80/303 (26%), Positives = 134/303 (44%), Gaps = 30/303 (9%)

Query: 56  DALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLT 115
           D  G   L P  +K    KW+RP +    P  I   +S   + Q  + +C F+A+ A   
Sbjct: 243 DRWGKLPLSP-KQKTTFSKWVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISA 300

Query: 116 LYPRLLRR------VVPPGQDFQHGY--AGVFHFQLWQFGRWMDVVVDDRLPV-REGKLM 166
            Y R   +      + P  +D +  Y   G +  +L   G    V++DD+LPV  +G+L+
Sbjct: 301 AYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELL 360

Query: 167 FVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSM---- 222
              S  ++E W  L+EKAY K+ G Y+   G + N      TG + E + +  +S     
Sbjct: 361 CSYSNNKSELWVSLIEKAYMKVMGGYD-FPGSNSNIDLHALTGWIPERIAMHSDSQTFSK 419

Query: 223 -GLFSALRHALAKESLVGATALSDRGEYRTEE-GLVKGHAYSITGTHKVFLGFTKVRLLR 280
              F  L     K  ++   +     E   E+ GLV  HAY++    +    F  +R ++
Sbjct: 420 DNSFRMLYQRFHKGDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIRE----FKGLRFIQ 475

Query: 281 LRNPWGCVEWTGAWSDS-CPRWDT-----LPTECRDALLVKKEDGEFWMELRDFLLHFDT 334
           L+NPW  + W G +S++    W       L  + R A   K ++G FW+   D   ++D 
Sbjct: 476 LKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDPRTA--QKIDNGIFWISWDDLCQYYDV 533

Query: 335 VQI 337
           + +
Sbjct: 534 IYL 536


>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
           sapiens]
          Length = 217

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 10/150 (6%)

Query: 556 FQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQLLQCFG--HGQSLALH 613
           F  +AG++ E++A +LQ  L+ +         T     L TC  ++      H   +  +
Sbjct: 58  FSAVAGQDGEVDAEELQRCLTQS-----GINGTYSPFSLETCRIMIAMLDRDHTGKMGFN 112

Query: 614 HFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRL 673
            F++LW  L  W+  F   D+D SGT+  +ELR A+   G+ L+ Q   T+  RY  +  
Sbjct: 113 AFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNG- 171

Query: 674 RVDFERFVSCVAHLTCI--FCHCSQHLDGG 701
           R+ F+ +V+C   L  +  F     HL  G
Sbjct: 172 RIFFDDYVACCVKLRALTDFFRKRDHLQQG 201


>gi|13186314 calpain 10 isoform g [Homo sapiens]
          Length = 139

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 35/85 (41%), Positives = 45/85 (52%)

Query: 45  LFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGN 104
           LFRD  FPA   +L  D   P ++  + + W RP E CA P+   +D     V QG LG+
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 105 CWFLAAAASLTLYPRLLRRVVPPGQ 129
           CWFL A A+L     LL +V  P Q
Sbjct: 73  CWFLCACAALQKSRHLLDQVSCPVQ 97


>gi|38679884 sorcin isoform b [Homo sapiens]
          Length = 183

 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 36/137 (26%), Positives = 67/137 (48%), Gaps = 8/137 (5%)

Query: 556 FQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQLLQCFGHGQS--LALH 613
           F  +AG++ +++A +LQ  L+ +           +   L TC  ++       S  +  +
Sbjct: 24  FAAVAGQDGQIDADELQRCLTQS-----GIAGGYKPFNLETCRLMVSMLDRDMSGTMGFN 78

Query: 614 HFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRL 673
            F++LW  L  W+  F  FD D SGT++  EL+ AL   GF L+ Q   ++  RY  +  
Sbjct: 79  EFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRY-STNG 137

Query: 674 RVDFERFVSCVAHLTCI 690
           ++ F+ +++C   L  +
Sbjct: 138 KITFDDYIACCVKLRAL 154


>gi|4507207 sorcin isoform a [Homo sapiens]
          Length = 198

 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 36/137 (26%), Positives = 67/137 (48%), Gaps = 8/137 (5%)

Query: 556 FQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQLLQCFGHGQS--LALH 613
           F  +AG++ +++A +LQ  L+ +           +   L TC  ++       S  +  +
Sbjct: 39  FAAVAGQDGQIDADELQRCLTQS-----GIAGGYKPFNLETCRLMVSMLDRDMSGTMGFN 93

Query: 614 HFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRL 673
            F++LW  L  W+  F  FD D SGT++  EL+ AL   GF L+ Q   ++  RY  +  
Sbjct: 94  EFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRY-STNG 152

Query: 674 RVDFERFVSCVAHLTCI 690
           ++ F+ +++C   L  +
Sbjct: 153 KITFDDYIACCVKLRAL 169


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,470,619
Number of Sequences: 37866
Number of extensions: 1474076
Number of successful extensions: 5089
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 4894
Number of HSP's gapped (non-prelim): 92
length of query: 719
length of database: 18,247,518
effective HSP length: 110
effective length of query: 609
effective length of database: 14,082,258
effective search space: 8576095122
effective search space used: 8576095122
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.