Search of human proteins with 12408656

Search of human proteins with 12408656

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|12408656 calpain 1, large subunit [Homo sapiens]
         (714 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|12408656 calpain 1, large subunit [Homo sapiens]                  1453   0.0  
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       953   0.0  
gi|221554549 calpain 8 [Homo sapiens]                                 864   0.0  
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       853   0.0  
gi|215490104 calpain 11 [Homo sapiens]                                822   0.0  
gi|27765074 calpain 3 isoform c [Homo sapiens]                        784   0.0  
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                         752   0.0  
gi|27765072 calpain 3 isoform b [Homo sapiens]                        745   0.0  
gi|4557405 calpain 3 isoform a [Homo sapiens]                         743   0.0  
gi|47078247 calpain 3 isoform f [Homo sapiens]                        717   0.0  
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                         712   0.0  
gi|38707981 calpain 12 [Homo sapiens]                                 549   e-156
gi|223468608 calpain 14 [Homo sapiens]                                448   e-126
gi|41152101 calpain 13 [Homo sapiens]                                 345   6e-95
gi|37577157 calpain 5 [Homo sapiens]                                  337   2e-92
gi|27765076 calpain 3 isoform d [Homo sapiens]                        281   1e-75
gi|13186316 calpain 6 [Homo sapiens]                                  270   3e-72
gi|13186302 calpain 10 isoform a [Homo sapiens]                       223   6e-58
gi|89353291 calpain 10 isoform c [Homo sapiens]                       218   2e-56
gi|14161692 calpain small subunit 2 [Homo sapiens]                    195   1e-49
gi|4502565 calpain, small subunit 1 [Homo sapiens]                    190   5e-48
gi|51599151 calpain, small subunit 1 [Homo sapiens]                   190   5e-48
gi|27765080 calpain 3 isoform e [Homo sapiens]                        189   8e-48
gi|27765078 calpain 3 isoform e [Homo sapiens]                        189   8e-48
gi|5032105 small optic lobes [Homo sapiens]                           156   7e-38
gi|7656959 calpain 7 [Homo sapiens]                                    96   1e-19
gi|38679884 sorcin isoform b [Homo sapiens]                            95   3e-19
gi|4507207 sorcin isoform a [Homo sapiens]                             95   3e-19
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap...    89   1e-17
gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]            77   4e-14

>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score = 1453 bits (3762), Expect = 0.0
 Identities = 714/714 (100%), Positives = 714/714 (100%)

Query: 1   MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA 60
           MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
Sbjct: 1   MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA 60

Query: 61  FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA 120
           FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
Sbjct: 61  FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA 120

Query: 121 IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS 180
           IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
Sbjct: 121 IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS 180

Query: 181 AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK 240
           AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
Sbjct: 181 AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK 240

Query: 241 ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE 300
           ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
Sbjct: 241 ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE 300

Query: 301 VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS 360
           VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
Sbjct: 301 VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS 360

Query: 361 RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV 420
           RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
Sbjct: 361 RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV 420

Query: 421 LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL 480
           LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
Sbjct: 421 LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL 480

Query: 481 REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE 540
           REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
Sbjct: 481 REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE 540

Query: 541 EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD 600
           EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
Sbjct: 541 EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD 600

Query: 601 GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII 660
           GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
Sbjct: 601 GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII 660

Query: 661 TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714
           TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
Sbjct: 661 TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  953 bits (2464), Expect = 0.0
 Identities = 441/696 (63%), Positives = 564/696 (81%), Gaps = 3/696 (0%)

Query: 13  GVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKD 72
           G++A++ K R    GLG HE AIKYL QDYE LR  CL++GTLF+D +FP +P +LG+K+
Sbjct: 3   GIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKE 62

Query: 73  LGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLH 132
           LGP SSKT GI+WKRPTE+ ++PQFI+ GATRTDICQGALGDCWLLAAIASLTLN+ +L 
Sbjct: 63  LGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILA 122

Query: 133 RVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLE 192
           RVVP  QSFQ  YAGIFHFQ WQ+GEWV+VVVDD LP KDG+L+FVHSAEG+EFWSALLE
Sbjct: 123 RVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLE 182

Query: 193 KAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSI 252
           KAYAK+NG YEALSGG+T+EGFEDFTGG+ EWYEL+K P +L++II KAL++GSLLGCSI
Sbjct: 183 KAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI 242

Query: 253 DISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSS 312
           DI+S  D EAITF+KLVKGHAYSVTGA++V   G +  LIR+RNPWGEVEWTG W+D+  
Sbjct: 243 DITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCP 302

Query: 313 EWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYE 372
            WN +DP ER++L  + EDGEFWMSF DF+R ++RLEICNLTPD L S T +KW  T  +
Sbjct: 303 SWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMD 362

Query: 373 GTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRER 432
           G WRRGSTAGGCRNYP TFW+NPQ+ I+L+E D+ ++  D ESGC+F++ L+QKHRRR+R
Sbjct: 363 GNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEE--DGESGCTFLVGLIQKHRRRQR 420

Query: 433 RFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPG 492
           + G DM TIGF +YEVP EL GQ  +HL ++FFL N +R RS+ FINLREV  RF+LPPG
Sbjct: 421 KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPG 480

Query: 493 EYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFR 552
           EY++VPSTFEPNK+GDF +R FSEK A    +DD+I+ANL +E  +SE++ID+ F+ LF 
Sbjct: 481 EYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANL-EEFDISEDDIDDGFRRLFA 539

Query: 553 QLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNI 612
           QLAGED EIS  EL+TIL R+++K +D+++ GFS+E+C+ MV+++D DG+GKLGL EF I
Sbjct: 540 QLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYI 599

Query: 613 LWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDF 672
           LW +I+ Y  I+R+ D+D+SG+M++YEMR A+E AGFK+  +L+++I+ R+++  L +DF
Sbjct: 600 LWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDF 659

Query: 673 DNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWL 708
           DNFV CLVRLET+F+ FK LD +  G +  DL  WL
Sbjct: 660 DNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  864 bits (2233), Expect = 0.0
 Identities = 406/694 (58%), Positives = 522/694 (75%)

Query: 15  SAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLG 74
           +A V +QRA   GLG ++NA+KYLGQD++ LR +CL SG LF+D  FP  P +LGYKDLG
Sbjct: 5   AAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLG 64

Query: 75  PNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRV 134
           P S +T GI WKRPTEL  +PQFIV GATRTDICQG LGDCWLLAAIASLTLN+ LL+RV
Sbjct: 65  PGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRV 124

Query: 135 VPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKA 194
           VP  Q FQ  YAGIFHFQ WQ+GEWV+VV+DD LP K+G+L+F+HS +GNEFWSALLEKA
Sbjct: 125 VPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKA 184

Query: 195 YAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDI 254
           YAK+NG YEAL+GGST EGFEDFTGG++E+Y+L+K P++LYQII KAL  GSLLGCSID+
Sbjct: 185 YAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDV 244

Query: 255 SSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEW 314
           SS  + EAIT +KLVK HAYSVTG ++VN++G    LIR+RNPWGEVEW+GAWSD + EW
Sbjct: 245 SSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEW 304

Query: 315 NNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGT 374
           N++DP  +++L  K+EDGEFWMS  DF+R+F+RLEICNL+PD+L S  + KWN  L+ G 
Sbjct: 305 NHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGH 364

Query: 375 WRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRF 434
           W RGSTAGGC+NYPAT+W NPQFKIRLDE D+  +    E  C+ +L LMQK+RR  +R 
Sbjct: 365 WTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRI 424

Query: 435 GRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEY 494
           G+ M +IG+AVY+VP EL      HL RDFFLA    AR+  ++NLREVS R RLPPGEY
Sbjct: 425 GQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEY 484

Query: 495 VVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQL 554
           +VVPSTFEP K+G+F LR FSEK A  +E+ D +  N  +      ++ D+ F+ LF +L
Sbjct: 485 LVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRLFEKL 544

Query: 555 AGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILW 614
           AG+D EI+   L+ +LN   SK  D++  GF++ +CR M++L+D +G G LG VEF  LW
Sbjct: 545 AGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLW 604

Query: 615 NRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDN 674
            +I+ YL I+ + D + SG++ A+EMR A+  AGF LN ++ + I  RY+   L ++FD+
Sbjct: 605 LKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDS 664

Query: 675 FVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWL 708
           FV C++RLET+F+ F  LD D DG+V   L +WL
Sbjct: 665 FVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  853 bits (2203), Expect = 0.0
 Identities = 394/619 (63%), Positives = 504/619 (81%), Gaps = 3/619 (0%)

Query: 90  ELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIF 149
           E+ ++PQFI+ GATRTDICQGALGDCWLLAAIASLTLN+ +L RVVP  QSFQ  YAGIF
Sbjct: 2   EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61

Query: 150 HFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGS 209
           HFQ WQ+GEWV+VVVDD LP KDG+L+FVHSAEG+EFWSALLEKAYAK+NG YEALSGG+
Sbjct: 62  HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121

Query: 210 TSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLV 269
           T+EGFEDFTGG+ EWYEL+K P +L++II KAL++GSLLGCSIDI+S  D EAITF+KLV
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181

Query: 270 KGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKM 329
           KGHAYSVTGA++V   G +  LIR+RNPWGEVEWTG W+D+   WN +DP ER++L  + 
Sbjct: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241

Query: 330 EDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPA 389
           EDGEFWMSF DF+R ++RLEICNLTPD L S T +KW  T  +G WRRGSTAGGCRNYP 
Sbjct: 242 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301

Query: 390 TFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVP 449
           TFW+NPQ+ I+L+E D+ ++  D ESGC+F++ L+QKHRRR+R+ G DM TIGF +YEVP
Sbjct: 302 TFWMNPQYLIKLEEEDEDEE--DGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVP 359

Query: 450 PELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDF 509
            EL GQ  +HL ++FFL N +R RS+ FINLREV  RF+LPPGEY++VPSTFEPNK+GDF
Sbjct: 360 EELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDF 419

Query: 510 VLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTI 569
            +R FSEK A    +DD+I+ANL +E  +SE++ID+ F+ LF QLAGED EIS  EL+TI
Sbjct: 420 CIRVFSEKKADYQAVDDEIEANL-EEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTI 478

Query: 570 LNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDL 629
           L R+++K +D+++ GFS+E+C+ MV+++D DG+GKLGL EF ILW +I+ Y  I+R+ D+
Sbjct: 479 LRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDV 538

Query: 630 DKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFF 689
           D+SG+M++YEMR A+E AGFK+  +L+++I+ R+++  L +DFDNFV CLVRLET+F+ F
Sbjct: 539 DRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIF 598

Query: 690 KTLDTDLDGVVTFDLFKWL 708
           K LD +  G +  DL  WL
Sbjct: 599 KQLDPENTGTIELDLISWL 617


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  822 bits (2124), Expect = 0.0
 Identities = 387/705 (54%), Positives = 520/705 (73%), Gaps = 5/705 (0%)

Query: 12  TGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYK 71
           TG+ A +   R +  G+G+H+NA  +  Q +E+LR  CL+ G LF D  FP  P SLG+K
Sbjct: 36  TGMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFK 95

Query: 72  DLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLL 131
           DLGPNS     I W+RP ++++NP FI+DG + TDICQG LGDCWLLAAI SLT    LL
Sbjct: 96  DLGPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLL 155

Query: 132 HRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALL 191
           +RVVP GQSF+  YAGIFHFQ+WQFG+WV+VVVDD LP K+ KLVFVHS E +EFWSALL
Sbjct: 156 YRVVPRGQSFKKNYAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALL 215

Query: 192 EKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCS 251
           EKAYAK++GSYEALSGGST EG EDFTGGV + ++L++ P +L +++ KA+ER SL+GCS
Sbjct: 216 EKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCS 275

Query: 252 IDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSS 311
           I+++S  ++E++T K LV+GHAYSVTG + V+YRG++ +LIR+RNPWG +EW GAWSDS+
Sbjct: 276 IEVTSDSELESMTDKMLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSA 335

Query: 312 SEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLY 371
            EW  V    + QL  K EDGEFWMS++DF+  FT LEICNLTPD L       W+TT Y
Sbjct: 336 REWEEVASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFY 395

Query: 372 EGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESG---CSFVLALMQKHR 428
           EG+WRRGS+AGGCRN+P TFW NPQFKI L E DDP+D  D E     C+ ++ALMQK+ 
Sbjct: 396 EGSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPED--DAEGNVVVCTCLVALMQKNW 453

Query: 429 RRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFR 488
           R  R+ G  ++TIGF +Y VP E      VHLK++FF        SE F N REVS++ R
Sbjct: 454 RHARQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLR 513

Query: 489 LPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFK 548
           LPPGEY+++PSTFEP+++ DF+LR F+EK + + ELD+   A    E+ +SE+++D++F 
Sbjct: 514 LPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFL 573

Query: 549 ALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLV 608
            LF+ +AGE  EI V EL+ +LNR+  K K  +TKGF L++CR M+NLMD+DG+GKLGL+
Sbjct: 574 HLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLL 633

Query: 609 EFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDL 668
           EF ILW +++ ++ IFR+ D D SG++++YEMR+ IE AG KLN K+ ++++ RY++ DL
Sbjct: 634 EFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDL 693

Query: 669 AVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMF 713
            +DFD+F+ C +RL+TMF FF T+D    G +   L +WLQ+TM+
Sbjct: 694 IIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score =  784 bits (2024), Expect = 0.0
 Identities = 376/678 (55%), Positives = 501/678 (73%), Gaps = 14/678 (2%)

Query: 42  YEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDG 101
           +EQL  +CL+   L+ D  FPP   SL Y    P         WKRP E+  NP+FI+DG
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115

Query: 102 ATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVD 161
           A RTDICQG LGDCW LAAIA LTLN  LL RV+PH QSF   YAGIFHFQ W++GEWVD
Sbjct: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175

Query: 162 VVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGV 221
           VV+DD LP  + +LVF  S   NEFWSALLEKAYAK++GSYEAL GG+T+E  EDFTGGV
Sbjct: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235

Query: 222 TEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQ 281
            E++E+R APSD+Y+I+ KA+ERGSL+GCSID    +  E      LV+GHAYSVTG  +
Sbjct: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDE 295

Query: 282 VNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKM-EDGEFWMSFRD 340
           V ++G+ V L+R+RNPWG+VEW G+WSD   +W+ VD  E+ +L+ ++ EDGEFWMS+ D
Sbjct: 296 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 355

Query: 341 FMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIR 400
           F+  FT+LEICNLT DAL+S  ++ W  ++ EG W RG +AGGCRN+P TFW NPQ++++
Sbjct: 356 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 415

Query: 401 -LDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVH 459
            L+E DDPD   D E  CSF++ALMQK+RR++R+ G  + TIGFA+YEVP E+ G    H
Sbjct: 416 LLEEDDDPD---DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-H 471

Query: 460 LKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSA 519
           L++DFFL NAS+ARS+ +IN+REVS RFRLPP EYV+VPST+EP++EG+F+LR FSEK  
Sbjct: 472 LQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRN 531

Query: 520 GTVELDDQIQANLPDEQVLS---EEEIDENFKALFRQLAGEDMEISVKELRTILNRIISK 576
            + E+++ I  + P  Q  S   E E  + F+ +F+Q+AG+DMEI   EL+ +LN +++K
Sbjct: 532 LSEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNK 591

Query: 577 HKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMS 636
           HKDL+T GF+LESCRSM+ LMD DG+GKL L EF+ LWN+I+ +  IF+ +D D+SG+++
Sbjct: 592 HKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTIN 651

Query: 637 AYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDL 696
           +YEMR A+  AGF LN +LY++I  RY++  + +DFD+F+CC VRLE MFR F   D D 
Sbjct: 652 SYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDG 711

Query: 697 DGVVTFDLFKWLQLTMFA 714
           DG++  ++ +WLQLTM+A
Sbjct: 712 DGIIKLNVLEWLQLTMYA 729


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score =  752 bits (1942), Expect = 0.0
 Identities = 368/679 (54%), Positives = 488/679 (71%), Gaps = 21/679 (3%)

Query: 39  GQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFI 98
           GQ +EQ+R  CLQ GTLF D  FP    SL Y +            WKRP E++ NP+FI
Sbjct: 26  GQSFEQMRQECLQRGTLFEDADFPASNSSLFYSE-----RPQIPFVWKRPGEIVKNPEFI 80

Query: 99  VDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGE 158
           + GATRTDICQG LGDCWLLAAIASLTLN   L RV+P  QSF  GYAGIFHFQ WQ  E
Sbjct: 81  LGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSE 140

Query: 159 WVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFT 218
           W+DVV+DD LP    +LVF+HSA+ NEFWSALLEKAYAK+NGSYEAL GGS  E  EDFT
Sbjct: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200

Query: 219 GGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTG 278
           GGV E ++ ++AP + Y+I+ KAL+RGSLLGC ID  S  + EA T   L+KGHAYSVTG
Sbjct: 201 GGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260

Query: 279 AKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQL-RVKMEDGEFWMS 337
             QV++RGQ + LIR+RNPWG+VEW G+WSDSS EW +V P E+ +L    ++DGEFWM+
Sbjct: 261 IDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMA 320

Query: 338 FRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQF 397
           F+DF   F ++EICNLTPDAL+   I KW  T+++G+W RGSTAGGCRN+  TFW NPQ 
Sbjct: 321 FKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQI 380

Query: 398 KIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPA 457
           K+ L E D+    G  E  CSF++ALMQK RR+ +RFG ++ TIG+A+YE P +      
Sbjct: 381 KLSLTEKDE----GQEE--CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----D 429

Query: 458 VHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEK 517
            HL +DFF  +ASRARS+ FINLREVS RF+LPPGEY+++PSTFEP++E DF LR FSEK
Sbjct: 430 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 489

Query: 518 SAGTVELDDQIQANLPDEQVLS----EEEIDENFKALFRQLAGEDMEISVKELRTILNRI 573
            A T ++D  +  +LP+    +    E E ++ F+ALF Q+AGEDME++ +EL  +LN +
Sbjct: 490 KAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAV 549

Query: 574 ISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSG 633
           + K KD++ K  SL SC+++++LMD  GNGKL   EF + W++++ ++++F +FD DKSG
Sbjct: 550 LQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSG 609

Query: 634 SMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLD 693
           +MS YE+R A+++AGF+L+  L +LI+ RY++ +L +DFD+F+ CLVRLE   R F+ L 
Sbjct: 610 TMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALS 669

Query: 694 TDLDGVVTFDLFKWLQLTM 712
           T     +  ++ +++ LTM
Sbjct: 670 TKNKEFIHLNINEFIHLTM 688


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score =  745 bits (1923), Expect = 0.0
 Identities = 376/764 (49%), Positives = 508/764 (66%), Gaps = 100/764 (13%)

Query: 42  YEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDG 101
           +EQL  +CL+   L+ D  FPP   SL Y    P         WKRP E+  NP+FI+DG
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115

Query: 102 ATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVD 161
           A RTDICQG LGDCW LAAIA LTLN  LL RV+PH QSF   YAGIFHFQ W++GEWVD
Sbjct: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175

Query: 162 VVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGV 221
           VV+DD LP  + +LVF  S   NEFWSALLEKAYAK++GSYEAL GG+T+E  EDFTGGV
Sbjct: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235

Query: 222 TEWYELRKAPSDLYQIILKALERGSLLGC----------------------------SID 253
            E++E+R APSD+Y+I+ KA+ERGSL+GC                            ++D
Sbjct: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295

Query: 254 ISSVLDMEA---------------ITFKK-----LVKGHAYSVTGAKQVNYRGQVVSLIR 293
            S + D +                + ++      LV+GHAYSVTG  +V ++G+ V L+R
Sbjct: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355

Query: 294 MRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKM-EDGEFWMSFRDFMREFTRLEICN 352
           +RNPWG+VEW G+WSD   +W+ VD  E+ +L+ ++ EDGEFWMS+ DF+  FT+LEICN
Sbjct: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415

Query: 353 LTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIR-LDETDDPDDYG 411
           LT DAL+S  ++ W  ++ EG W RG +AGGCRN+P TFW NPQ++++ L+E DDPD   
Sbjct: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPD--- 472

Query: 412 DRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASR 471
           D E  CSF++ALMQK+RR++R+ G  + TIGFA+YEVP E+ G    HL++DFFL NAS+
Sbjct: 473 DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASK 531

Query: 472 ARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQAN 531
           ARS+ +IN+REVS RFRLPP EYV+VPST+EP++EG+F+LR FSEK   + E+++ I  +
Sbjct: 532 ARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVD 591

Query: 532 -------------------------------LPDEQVLS----------EEEIDENFKAL 550
                                           PD+Q  S          E E  + F+ +
Sbjct: 592 RPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNI 651

Query: 551 FRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEF 610
           F+Q+AG+DMEI   EL+ +LN +++KHKDL+T GF+LESCRSM+ LMD DG+GKL L EF
Sbjct: 652 FKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEF 711

Query: 611 NILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAV 670
           + LWN+I+ +  IF+ +D D+SG++++YEMR A+  AGF LN +LY++I  RY++  + +
Sbjct: 712 HHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNI 771

Query: 671 DFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714
           DFD+F+CC VRLE MFR F   D D DG++  ++ +WLQLTM+A
Sbjct: 772 DFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 815


>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score =  743 bits (1917), Expect = 0.0
 Identities = 376/770 (48%), Positives = 508/770 (65%), Gaps = 106/770 (13%)

Query: 42  YEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDG 101
           +EQL  +CL+   L+ D  FPP   SL Y    P         WKRP E+  NP+FI+DG
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115

Query: 102 ATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVD 161
           A RTDICQG LGDCW LAAIA LTLN  LL RV+PH QSF   YAGIFHFQ W++GEWVD
Sbjct: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175

Query: 162 VVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGV 221
           VV+DD LP  + +LVF  S   NEFWSALLEKAYAK++GSYEAL GG+T+E  EDFTGGV
Sbjct: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235

Query: 222 TEWYELRKAPSDLYQIILKALERGSLLGC----------------------------SID 253
            E++E+R APSD+Y+I+ KA+ERGSL+GC                            ++D
Sbjct: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMD 295

Query: 254 ISSVLDMEA---------------ITFKK-----LVKGHAYSVTGAKQVNYRGQVVSLIR 293
            S + D +                + ++      LV+GHAYSVTG  +V ++G+ V L+R
Sbjct: 296 NSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVR 355

Query: 294 MRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKM-EDGEFWMSFRDFMREFTRLEICN 352
           +RNPWG+VEW G+WSD   +W+ VD  E+ +L+ ++ EDGEFWMS+ DF+  FT+LEICN
Sbjct: 356 LRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICN 415

Query: 353 LTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIR-LDETDDPDDYG 411
           LT DAL+S  ++ W  ++ EG W RG +AGGCRN+P TFW NPQ++++ L+E DDPD   
Sbjct: 416 LTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPD--- 472

Query: 412 DRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASR 471
           D E  CSF++ALMQK+RR++R+ G  + TIGFA+YEVP E+ G    HL++DFFL NAS+
Sbjct: 473 DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASK 531

Query: 472 ARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQAN 531
           ARS+ +IN+REVS RFRLPP EYV+VPST+EP++EG+F+LR FSEK   + E+++ I  +
Sbjct: 532 ARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVD 591

Query: 532 -------------------------------------LPDEQVLS----------EEEID 544
                                                 PD+Q  S          E E  
Sbjct: 592 RPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQ 651

Query: 545 ENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGK 604
           + F+ +F+Q+AG+DMEI   EL+ +LN +++KHKDL+T GF+LESCRSM+ LMD DG+GK
Sbjct: 652 QQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGK 711

Query: 605 LGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYS 664
           L L EF+ LWN+I+ +  IF+ +D D+SG++++YEMR A+  AGF LN +LY++I  RY+
Sbjct: 712 LNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYA 771

Query: 665 EPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714
           +  + +DFD+F+CC VRLE MFR F   D D DG++  ++ +WLQLTM+A
Sbjct: 772 DKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score =  717 bits (1851), Expect = 0.0
 Identities = 358/720 (49%), Positives = 488/720 (67%), Gaps = 95/720 (13%)

Query: 86  KRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGY 145
           ++  E+  NP+FI+DGA RTDICQG LGDCW LAAIA LTLN  LL RV+PH QSF   Y
Sbjct: 13  QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY 72

Query: 146 AGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEAL 205
           AGIFHFQ W++GEWVDVV+DD LP  + +LVF  S   NEFWSALLEKAYAK++GSYEAL
Sbjct: 73  AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEAL 132

Query: 206 SGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGC--------------- 250
            GG+T+E  EDFTGGV E++E+R APSD+Y+I+ KA+ERGSL+GC               
Sbjct: 133 KGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPS 192

Query: 251 -------------SIDISSVLDMEA---------------ITFKK-----LVKGHAYSVT 277
                        ++D S + D +                + ++      LV+GHAYSVT
Sbjct: 193 GLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVT 252

Query: 278 GAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKM-EDGEFWM 336
           G  +V ++G+ V L+R+RNPWG+VEW G+WSD   +W+ VD  E+ +L+ ++ EDGEFWM
Sbjct: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312

Query: 337 SFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQ 396
           S+ DF+  FT+LEICNLT DAL+S  ++ W  ++ EG W RG +AGGCRN+P TFW NPQ
Sbjct: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQ 372

Query: 397 FKIR-LDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQ 455
           ++++ L+E DDPD   D E  CSF++ALMQK+RR++R+ G  + TIGFA+YEVP E+ G 
Sbjct: 373 YRLKLLEEDDDPD---DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGN 429

Query: 456 PAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFS 515
              HL++DFFL NAS+ARS+ +IN+REVS RFRLPP EYV+VPST+EP++EG+F+LR FS
Sbjct: 430 KQ-HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFS 488

Query: 516 EKSAGTVELDDQIQAN-------------------------------LPDEQVLS----- 539
           EK   + E+++ I  +                                PD+Q  S     
Sbjct: 489 EKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQP 548

Query: 540 -----EEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMV 594
                E E  + F+ +F+Q+AG+DMEI   EL+ +LN +++KHKDL+T GF+LESCRSM+
Sbjct: 549 GSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMI 608

Query: 595 NLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKK 654
            LMD DG+GKL L EF+ LWN+I+ +  IF+ +D D+SG++++YEMR A+  AGF LN +
Sbjct: 609 ALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQ 668

Query: 655 LYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714
           LY++I  RY++  + +DFD+F+CC VRLE MFR F   D D DG++  ++ +WLQLTM+A
Sbjct: 669 LYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score =  712 bits (1838), Expect = 0.0
 Identities = 355/678 (52%), Positives = 470/678 (69%), Gaps = 45/678 (6%)

Query: 39  GQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFI 98
           GQ +EQ+R  CLQ GTLF D  FP    SL Y +            WKRP E++ NP+FI
Sbjct: 26  GQSFEQMRQECLQRGTLFEDADFPASNSSLFYSE-----RPQIPFVWKRPGEIVKNPEFI 80

Query: 99  VDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGE 158
           + GATRTDICQG LGDCWLLAAIASLTLN   L RV+P  QSF  GYAGIFHFQ WQ  E
Sbjct: 81  LGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSE 140

Query: 159 WVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFT 218
           W+DVV+DD LP    +LVF+HSA+ NEFWSALLEKAYAK+NGSYEAL GGS  E  EDFT
Sbjct: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200

Query: 219 GGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTG 278
           GGV E ++ ++AP + Y+I+ KAL+RGSLLGC ID  S  + EA T   L+KGHAYSVTG
Sbjct: 201 GGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260

Query: 279 AKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSF 338
             QV++RGQ + LIR+RNPWG+VEW G+WSD                          M+F
Sbjct: 261 IDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAF 295

Query: 339 RDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFK 398
           +DF   F ++EICNLTPDAL+   I KW  T+++G+W RGSTAGGCRN+  TFW NPQ K
Sbjct: 296 KDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIK 355

Query: 399 IRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAV 458
           + L E D+    G  E  CSF++ALMQK RR+ +RFG ++ TIG+A+YE P +       
Sbjct: 356 LSLTEKDE----GQEE--CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----DE 404

Query: 459 HLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKS 518
           HL +DFF  +ASRARS+ FINLREVS RF+LPPGEY+++PSTFEP++E DF LR FSEK 
Sbjct: 405 HLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKK 464

Query: 519 AGTVELDDQIQANLPDEQVLS----EEEIDENFKALFRQLAGEDMEISVKELRTILNRII 574
           A T ++D  +  +LP+    +    E E ++ F+ALF Q+AGEDME++ +EL  +LN ++
Sbjct: 465 AITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 524

Query: 575 SKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGS 634
            K KD++ K  SL SC+++++LMD  GNGKL   EF + W++++ ++++F +FD DKSG+
Sbjct: 525 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 584

Query: 635 MSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDT 694
           MS YE+R A+++AGF+L+  L +LI+ RY++ +L +DFD+F+ CLVRLE   R F+ L T
Sbjct: 585 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 644

Query: 695 DLDGVVTFDLFKWLQLTM 712
                +  ++ +++ LTM
Sbjct: 645 KNKEFIHLNINEFIHLTM 662


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  549 bits (1415), Expect = e-156
 Identities = 302/705 (42%), Positives = 419/705 (59%), Gaps = 39/705 (5%)

Query: 37  YLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQ 96
           + GQ YE +R  CL SG LFRD  FP  P +LGY  LGP+S K  G+KW RP E  + P+
Sbjct: 27  FRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPK 86

Query: 97  FIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQF 156
           FI +  +RTD+CQG+LG+CW LAA ASLTL   LL RVVP GQ FQ+GYAG+FHFQLWQF
Sbjct: 87  FICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQF 146

Query: 157 GEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFED 216
           G W+DVVVDD LP+++GKL+FV S + NEFW+ LLEKAYAK++GSYE + GG  +E F D
Sbjct: 147 GRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVD 206

Query: 217 FTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDM-EAITFKKLVKGHAYS 275
           FTGGV E   LR+    L+  +  AL + SL+G     +++ D  E  T + LVKGHAYS
Sbjct: 207 FTGGVGEVLYLRQNSMGLFSALRHALAKESLVGA----TALSDRGEYRTEEGLVKGHAYS 262

Query: 276 VTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFW 335
           +TG  +V      V L+R+RNPWG VEWTGAWSDS   W+ +    RD L VK EDGEFW
Sbjct: 263 ITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVKKEDGEFW 322

Query: 336 MSFRDFMREFTRLEICNLTPDAL-KSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVN 394
           M  RDF+  F  ++IC+L+P+ L  S     W+   ++G W RG  +GG +    TFW N
Sbjct: 323 MELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTN 382

Query: 395 PQFKIRLDETDDPDD-------------------YGDRESGCSFVLALMQKHRRRERRFG 435
           PQF++ L E D+ DD                    G R   C+ +L+L+Q++RRR R  G
Sbjct: 383 PQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKG 442

Query: 436 RDMETIGFAVYEVPPELVG---QPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPG 492
               T+GF V+++P EL+G    P  H      L    RA        R+V+ R  L PG
Sbjct: 443 LTYLTVGFHVFQIPEELLGLWDSPRSHA----LLPRLLRADRSPLSARRDVTRRCCLRPG 498

Query: 493 EYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFR 552
            Y+VVPST     E DF LR FSE+    VE+DD I A+L   Q      ++   + LF+
Sbjct: 499 HYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQG-PYLPLELGLEQLFQ 557

Query: 553 QLAGEDMEISVKELRTILNRII--SKHKDLRTKGFSLESCRSMVNLMDRDGNGK-LGLVE 609
           +LAGE+ E++  +L+ +L+  +  ++      +   L +C  ++      G+G+ L L  
Sbjct: 558 ELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQLLQCF---GHGQSLALHH 614

Query: 610 FNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLA 669
           F  LW  +  + +IF KFD D SG+M++YE+R+A+ +AGF LN +L + + +RY +  L 
Sbjct: 615 FQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLR 674

Query: 670 VDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714
           VDF+ FV C+  L  +F          +GV+     +W+++  F+
Sbjct: 675 VDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  448 bits (1152), Expect = e-126
 Identities = 260/679 (38%), Positives = 384/679 (56%), Gaps = 26/679 (3%)

Query: 40  QDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIV 99
           QD+E L   CL++G LF D +FP    S+G   L         ++WKRP EL SNPQF  
Sbjct: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPR--LQWKRPPELHSNPQFYF 85

Query: 100 DGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEW 159
             A R D+CQG +GDCW LAA+ +L L+  +L RVVP  QSF   YAGIF F  W +G W
Sbjct: 86  AKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNW 145

Query: 160 VDVVVDDLLPIKD-GKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFT 218
           V VV+DD LP+ + G+LVFV S   N FW ALLEKAYAK++GSYE L  G  SE   DFT
Sbjct: 146 VPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205

Query: 219 GGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTG 278
           GGVT    L +A  +L+ I+++A    +L+GC          E I    LV+GHAY++TG
Sbjct: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSG-----EKILENGLVEGHAYTLTG 260

Query: 279 AKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSF 338
            ++V  + +   L+++RNPWG+VEW G WSDSSS+W  + P E+  L  K  DGEFWM+ 
Sbjct: 261 IRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTL 320

Query: 339 RDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRN-YPATFWVNPQF 397
           +DF   F  L IC LTP  L     +KW  T+ EG W + STAGG R     TFW NPQF
Sbjct: 321 QDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQF 380

Query: 398 KIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPA 457
            + +     P++       CS +++L+QK R R R+  + +  IGF +Y +      Q  
Sbjct: 381 LLSVWR---PEEGRRSLRPCSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNKYHDDQR- 435

Query: 458 VHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEK 517
             L  +FF  N   ++ ++F+  +EVS    L PG Y++VP   E +++ +FVLR FS K
Sbjct: 436 -RLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRK 494

Query: 518 SAGTVELDDQIQANLPDEQVLSEEEIDENFK--ALFRQLAGEDMEISVKELRTILNRIIS 575
                 +  +I +N     V S+E  D+N +    F +   +  EI+  +L+ +LN++  
Sbjct: 495 -----HIFYEIGSN--SGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQNLLNQMTW 547

Query: 576 KHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSM 635
                R   FSLE+C+ ++ L+D + +G + + EF  LW +++    +F K D   SG +
Sbjct: 548 SSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGYL 606

Query: 636 SAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTD 695
           +  ++  A+  AG  L+  + +L++ RY  P L +DF +F+  ++R+E M   F+ L  D
Sbjct: 607 NWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQD 666

Query: 696 LDGVVTFDLFKWLQLTMFA 714
             G+      +W+ + +++
Sbjct: 667 GKGIY-LQKPEWMMMALYS 684


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  345 bits (886), Expect = 6e-95
 Identities = 239/693 (34%), Positives = 343/693 (49%), Gaps = 52/693 (7%)

Query: 35  IKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSN 94
           IK+  QD+  LR  CL  G  F+DE FP    S+G K L     +   + WKRP +L   
Sbjct: 14  IKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLL--QEKRLSNVIWKRPQDLPGG 71

Query: 95  P-QFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQL 153
           P  FI+D  +R DI QG   DCW LAA+ SLT N     +++   QSF + YAGIF F+ 
Sbjct: 72  PPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRF 130

Query: 154 WQFGEWVDVVVDDLLPIKDGKLVFVHSAEGN-EFWSALLEKAYAKVNGSYEALSGGSTSE 212
           WQ G+WV+VV+DD LP++  K +FV     N EFW  LLEKAYAK+ GSY  L  G   +
Sbjct: 131 WQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLED 190

Query: 213 GFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGH 272
              D TGGV     L  +P DL + +  A + GSL+ C+   S   D        LV  H
Sbjct: 191 ALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATP-SGPTDTAQAMENGLVSLH 249

Query: 273 AYSVTGAKQVNYRGQVVSLIRMRNPWG--EVEWTGAWSDSSSEWNNVDPYERDQLRVKME 330
           AY+VTGA+Q+ YR     +I + NPWG  E EW G WSD S EW       + QL  K E
Sbjct: 250 AYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRE 309

Query: 331 DGEFWMSFRDFMREFTRLEICNLTPDAL-KSRTIRK-WNTTLYEGTWRRGSTAGGCRNYP 388
           DGEFWMS +DF ++F  + IC+  P  L    T+ + W+  ++      G+TAGG RN  
Sbjct: 310 DGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-- 367

Query: 389 ATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEV 448
                + QF   + E  +    G     C  V       +  + +F  D + I       
Sbjct: 368 -----DAQFNFSVQEPME----GTNVVVCVTVAVTPSNLKAEDAKFPLDFQVI------- 411

Query: 449 PPELVGQPAVHLKRD--FFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKE 506
              L G      K    FF +  +  +S      R  +  + L PG YVVV  T    K 
Sbjct: 412 ---LAGSQRFREKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKS 466

Query: 507 GDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKEL 566
            +F+LR F +       L      NL  +   SE    +   ++F + A + ++I   +L
Sbjct: 467 AEFLLRIFLKMPDSDRHLSSHF--NLRMKGSPSEHGSQQ---SIFNRYAQQRLDIDATQL 521

Query: 567 RTILNR--IISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIF 624
           + +LN+  +     D+    FSL+ CRS+V LM+   NG+L   EF  LW R+ +Y  +F
Sbjct: 522 QGLLNQELLTGPPGDM----FSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVF 577

Query: 625 RKFDLDKSGSMSAYEMRMAIESA----GFKLNKKLYELIITRYSEPDLAVDFDNFVCCLV 680
           +K      G + + ++  AIE+     G  ++++L  L+  RYS+    V F + VC L+
Sbjct: 578 QKVQ-TSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLM 636

Query: 681 RLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMF 713
           RLE M + F+ L  D  G+   ++ +W+ L M+
Sbjct: 637 RLEAMAKTFRNLSKDGKGLYLTEM-EWMSLVMY 668


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  337 bits (864), Expect = 2e-92
 Identities = 197/518 (38%), Positives = 284/518 (54%), Gaps = 57/518 (11%)

Query: 37  YLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDL-GPNSSKTYGIKWKRPTELLSNP 95
           Y  Q+Y  LR  C +   LF D  FP    SL YK   GP       ++WKRP  +  +P
Sbjct: 8   YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGP------AVRWKRPKGICEDP 61

Query: 96  QFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQ------NGYAGIF 149
           +  VDG +  D+ QG +G+CW +AA +SL   ++L  +V+P  +  +      N YAGIF
Sbjct: 62  RLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIF 121

Query: 150 HFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGS 209
           HF  W+FGEWVDVV+DD LP  + +L++ HS   NEFW AL+EKAYAK+ G Y+AL GG+
Sbjct: 122 HFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGN 181

Query: 210 TSEGFEDFTGGVTEWYELRKAP--------SDLYQIILKALERGSLLGCSIDISSVLDME 261
           T++   DFTGGV+E  +L +          + L++ +LK   RG L+  SI   +  DME
Sbjct: 182 TADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADME 241

Query: 262 AITFKKLVKGHAYSVTGAKQVN--------YRGQVVSLIRMRNPWGEVEWTGAWSDSSSE 313
           A     LVKGHAY+VT  ++V         ++ + + +IR+RNPWGE EW G WSD+S E
Sbjct: 242 ARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEE 301

Query: 314 WNNVDPYERDQLRVKM-EDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYE 372
           W  V   ER+++ V + +DGEFWM+F D  R FT +  C +   +  S   + W      
Sbjct: 302 WQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLS-IHKTWEEARLH 360

Query: 373 GTWR-----RGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKH 427
           G W      R +  GGC N+  TF+ NPQ+   + E   P+D          ++ + Q+ 
Sbjct: 361 GAWTLHEDPRQNRGGGCINHKDTFFQNPQY---IFEVKKPED--------EVLICIQQRP 409

Query: 428 RRRERRFGR-DMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTR 486
           +R  RR G+ +   IGF +Y+V  E   Q  +H       +   +A S  +IN R V  R
Sbjct: 410 KRSTRREGKGENLAIGFDIYKV--EENRQYRMH-------SLQHKAASSIYINSRSVFLR 460

Query: 487 FRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVEL 524
              P G YV++P+TFEP   G+F+LR F++  +   EL
Sbjct: 461 TDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCREL 498


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score =  281 bits (719), Expect = 1e-75
 Identities = 139/303 (45%), Positives = 199/303 (65%), Gaps = 47/303 (15%)

Query: 459 HLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKS 518
           HL++DFFL NAS+ARS+ +IN+REVS RFRLPP EYV+VPST+EP++EG+F+LR FSEK 
Sbjct: 7   HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 66

Query: 519 AGTVELDDQIQANLP-------------------------------------DEQVLS-- 539
             + E+++ I  + P                                     D+Q  S  
Sbjct: 67  NLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQ 126

Query: 540 --------EEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCR 591
                   E E  + F+ +F+Q+AG+DMEI   EL+ +LN +++KHKDL+T GF+LESCR
Sbjct: 127 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCR 186

Query: 592 SMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKL 651
           SM+ LMD DG+GKL L EF+ LWN+I+ +  IF+ +D D+SG++++YEMR A+  AGF L
Sbjct: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246

Query: 652 NKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLT 711
           N +LY++I  RY++  + +DFD+F+CC VRLE MFR F   D D DG++  ++ +WLQLT
Sbjct: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 306

Query: 712 MFA 714
           M+A
Sbjct: 307 MYA 309


>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score =  270 bits (690), Expect = 3e-72
 Identities = 171/512 (33%), Positives = 260/512 (50%), Gaps = 62/512 (12%)

Query: 37  YLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQ 96
           +  Q Y++L+  C++   LF D  F P   SL Y  L P       + WKRP ++  +P 
Sbjct: 8   FKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK-----VVWKRPQDICDDPH 62

Query: 97  FIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQ------NGYAGIFH 150
            IV   +   + QG LG   +++A + L + ++   + +P+ +  +        YAGIFH
Sbjct: 63  LIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFH 122

Query: 151 FQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGST 210
           F+ W FGEW +VV+DDLLP  +G LVF  S   NEFW+ALLEKAYAK+ G YEAL G + 
Sbjct: 123 FRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTI 182

Query: 211 SEGFEDFTGGVTEWYELRKA--------PSDLYQIILKALERGSLLGCSIDISSVLDMEA 262
           ++   DFTG + E  +++K            L+  + K   +G L+ CSI+  +  + E 
Sbjct: 183 TDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEV 242

Query: 263 ITFKKLVKGHAYSVTGAKQVN--------YRGQVVSLIRMRNPWGEVEWTGAWSDSSSEW 314
            T   L+KGH Y++T  +++         +  + V ++R+RNP G  EW+G WS+ S EW
Sbjct: 243 ETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEW 302

Query: 315 NNVDPYERDQLRVKM-EDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEG 373
             +   +R  L + M +DGEFWMS  DF R F +L +C    + +  R  ++  + L  G
Sbjct: 303 QQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGR--KELESVL--G 358

Query: 374 TWRRG-----STAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHR 428
            W        + +GGC N   TF  NPQ+   +            E G   +++L QK  
Sbjct: 359 CWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVP-----------EDGHKVIMSLQQKDL 407

Query: 429 RRERRFGR-DMETIGFAVYEVPPELVGQPAVHLKRDFFLAN---ASRARSEQFINLREVS 484
           R  RR GR D   IGF +++          V + R F L +     RA +  +I+ R V 
Sbjct: 408 RTYRRMGRPDNYIIGFELFK----------VEMNRKFRLHHLYIQERAGTSTYIDTRTVF 457

Query: 485 TRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSE 516
               L  G YV+VP+ F+  +  +F+LR FSE
Sbjct: 458 LSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSE 489


>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score =  223 bits (567), Expect = 6e-58
 Identities = 159/501 (31%), Positives = 231/501 (46%), Gaps = 66/501 (13%)

Query: 55  LFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGD 114
           LFRD AFP    SL      P +     I W+RP E+ + P+   D      + QG LGD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 115 CWLLAAIASLTLNDTLLHRVVPHGQSF--QNGYAGIFHFQLWQFGEWVDVVVDDLLPIKD 172
           CW L A A+L  +  LL +V+P GQ       Y G F  ++WQFG WV+V  DD LP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 173 GKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPS 232
           G+L F      + FW  LLEK YAKV+GSYE L  G  ++   D TGG+ E + L+    
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192

Query: 233 DLYQ------------IILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAK 280
              Q              L  L+   L+ C      VL   A   ++L + HA+ V+  +
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISC-----CVLSPRA-GARELGEFHAFIVSDLR 246

Query: 281 QV-NYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFR 339
           ++    GQ + L+R++NPWG   W G W +    W+ VD     +L  ++++GEFW+   
Sbjct: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEE 306

Query: 340 DFMREFTRLEICNLTPDA--LKSRTIRK--WNTTLYEGTWRRGSTAGGCRNYPATFWVNP 395
           +F+REF  L +     +A  L+S    +   +T    G W +G +AGGCRN  + F  NP
Sbjct: 307 EFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSNP 365

Query: 396 QFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRF--------------------- 434
           +F +R+ E  +              +A++Q+ R     +                     
Sbjct: 366 KFWLRVSEPSE------------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIP 413

Query: 435 GRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEY 494
           G+  + +G  +++V    V  P V L        A  A        REV  R  L PG Y
Sbjct: 414 GKHYQAVGLHLWKVEKRRVNLPRV-LSMPPVAGTACHAYD------REVHLRCELSPGYY 466

Query: 495 VVVPSTFEPNKEGDFVLRFFS 515
           + VPSTF  +  G+F+LR FS
Sbjct: 467 LAVPSTFLKDAPGEFLLRVFS 487



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 54/188 (28%), Positives = 79/188 (42%), Gaps = 21/188 (11%)

Query: 352 NLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYG 411
           N TP A  +    +W T    G+WR G TAGG RN+ A++  NP F   + E   P    
Sbjct: 502 NTTPGA--ALPAGEWGTVQLRGSWRVGQTAGGSRNF-ASYPTNPCFPFSVPEGPGP---- 554

Query: 412 DRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASR 471
                   V   + +H R       +   IGF +++VP     Q A  L     L +   
Sbjct: 555 ------RCVRITLHQHCRPS---DTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVP 605

Query: 472 ARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQAN 531
            R  Q     EVS    LP G Y VVPST+ P+ EG F +   +     ++   + +   
Sbjct: 606 HRYAQ-----EVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQF 660

Query: 532 LPDEQVLS 539
           L +  V++
Sbjct: 661 LQEVSVMA 668


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  218 bits (554), Expect = 2e-56
 Identities = 159/525 (30%), Positives = 239/525 (45%), Gaps = 64/525 (12%)

Query: 55  LFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGD 114
           LFRD AFP    SL      P +     I W+RP E+ + P+   D      + QG LGD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 115 CWLLAAIASLTLNDTLLHRVVPHGQSF--QNGYAGIFHFQLWQFGEWVDVVVDDLLPIKD 172
           CW L A A+L  +  LL +V+P GQ       Y G F  ++WQFG WV+V  DD LP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 173 GKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPS 232
           G+L F      + FW  LLEK YAKV+GSYE L  G  ++   D TGG+ E + L+    
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192

Query: 233 DLYQ------------IILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAK 280
              Q              L  L+   L+ C      VL   A   ++L + HA+ V+  +
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISC-----CVLSPRA-GARELGEFHAFIVSDLR 246

Query: 281 QV-NYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFR 339
           ++    GQ + L+R++NPWG   W G W +    W+ VD     +L  ++++GEFW+   
Sbjct: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEE 306

Query: 340 DFMREFTRLEICNLTPDA--LKSRTIRK--WNTTLYEGTWRRGSTAGGCRNYPATFWVNP 395
           +F+REF  L +     +A  L+S    +   +T    G W +G +AGGCRN  + F  NP
Sbjct: 307 EFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSNP 365

Query: 396 QFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRF--------------------- 434
           +F +R+ E  +              +A++Q+ R     +                     
Sbjct: 366 KFWLRVSEPSE------------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIP 413

Query: 435 GRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEY 494
           G+  + +G  +++VP     Q A  L     L +    R  Q     EVS    LP G Y
Sbjct: 414 GKHYQAVGLHLWKVPEGGRSQDAPPLLLQEPLLSCVPHRYAQ-----EVSRLCLLPAGTY 468

Query: 495 VVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLS 539
            VVPST+ P+ EG F +   +     ++   + +   L +  V++
Sbjct: 469 KVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEVSVMA 513


>gi|14161692 calpain small subunit 2 [Homo sapiens]
          Length = 248

 Score =  195 bits (495), Expect = 1e-49
 Identities = 87/176 (49%), Positives = 131/176 (74%)

Query: 539 SEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMD 598
           SE E    F+  F QLAG DME+   +L  ILN+++SKHKDL+T GFSL++CRS+V++MD
Sbjct: 73  SESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFSLDTCRSIVSVMD 132

Query: 599 RDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYEL 658
            D  GKLG  EF  LWN I+ +  +++++D D SGS+ + ++R A+++AGF+LN++LY++
Sbjct: 133 SDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQM 192

Query: 659 IITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714
           I+ RY+  D  +DF+NF+ CLVRL+ MFR FK+LD D DG++   + +WLQLTM++
Sbjct: 193 IVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMYS 248


>gi|4502565 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  190 bits (482), Expect = 5e-48
 Identities = 88/176 (50%), Positives = 127/176 (72%)

Query: 539 SEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMD 598
           +E E    F+ LF QLAG+DME+S  EL  ILN+++++H DL+T GF +++CRSMV +MD
Sbjct: 93  NESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMD 152

Query: 599 RDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYEL 658
            D  GKLG  EF  LWN I+ + +I+++FD D+SG++ + E+  A E+AGF LN+ LY +
Sbjct: 153 SDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNM 212

Query: 659 IITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714
           II RYS+    +DFDNF+ CLVRL+ MFR FK+LD D  G +  ++ +WLQLTM++
Sbjct: 213 IIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 268


>gi|51599151 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  190 bits (482), Expect = 5e-48
 Identities = 88/176 (50%), Positives = 127/176 (72%)

Query: 539 SEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMD 598
           +E E    F+ LF QLAG+DME+S  EL  ILN+++++H DL+T GF +++CRSMV +MD
Sbjct: 93  NESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMD 152

Query: 599 RDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYEL 658
            D  GKLG  EF  LWN I+ + +I+++FD D+SG++ + E+  A E+AGF LN+ LY +
Sbjct: 153 SDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNM 212

Query: 659 IITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714
           II RYS+    +DFDNF+ CLVRL+ MFR FK+LD D  G +  ++ +WLQLTM++
Sbjct: 213 IIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 268


>gi|27765080 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  189 bits (480), Expect = 8e-48
 Identities = 83/156 (53%), Positives = 119/156 (76%)

Query: 559 MEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIR 618
           MEI   EL+ +LN +++KHKDL+T GF+LESCRSM+ LMD DG+GKL L EF+ LWN+I+
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 619 NYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCC 678
            +  IF+ +D D+SG++++YEMR A+  AGF LN +LY++I  RY++  + +DFD+F+CC
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 679 LVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714
            VRLE MFR F   D D DG++  ++ +WLQLTM+A
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|27765078 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  189 bits (480), Expect = 8e-48
 Identities = 83/156 (53%), Positives = 119/156 (76%)

Query: 559 MEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIR 618
           MEI   EL+ +LN +++KHKDL+T GF+LESCRSM+ LMD DG+GKL L EF+ LWN+I+
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 619 NYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCC 678
            +  IF+ +D D+SG++++YEMR A+  AGF LN +LY++I  RY++  + +DFD+F+CC
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 679 LVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA 714
            VRLE MFR F   D D DG++  ++ +WLQLTM+A
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score =  156 bits (394), Expect = 7e-38
 Identities = 107/339 (31%), Positives = 165/339 (48%), Gaps = 31/339 (9%)

Query: 42  YEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSN------- 94
           +E +   C ++   F D++FPP P+S+G+     +S +    +W RP E+  +       
Sbjct: 474 WENIVAFCRENNVSFVDDSFPPGPESVGFP--AGDSVQQRVRQWLRPQEINCSVFRDHRA 531

Query: 95  PQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLW 154
              +      +DI QG LG+CW L+A+A L     L+ RV+        G    +  +L 
Sbjct: 532 TWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEG---AYQVRLC 588

Query: 155 QFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGF 214
           + G W  V+VDD+LP  +   +    A+  + W AL+EKA AK++GSY AL  G   EG 
Sbjct: 589 KDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGL 648

Query: 215 EDFTGGVTEWYEL-------RKAPSD---LYQIILKALERGSLLGCSIDISSV-LDMEAI 263
              TG   E   L       R+ P D   ++  +L + E G L+G S    ++ +D  A 
Sbjct: 649 ATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAY 708

Query: 264 TFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERD 323
               L   HAYS+   + V    Q   L+R+RNPWG   W G+WSD   EW +   + R 
Sbjct: 709 ESLGLRPRHAYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSD---EWPHWPGHLRG 761

Query: 324 QLRVK-MEDGEFWMSFRDFMREFTRLEICNLTPDALKSR 361
           +L      +G FWM + DF+R F  ++IC +  D  ++R
Sbjct: 762 ELMPHGSSEGVFWMEYGDFVRYFDSVDICKVHSDWQEAR 800


>gi|7656959 calpain 7 [Homo sapiens]
          Length = 813

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 120/482 (24%), Positives = 204/482 (42%), Gaps = 75/482 (15%)

Query: 3   EEIITPVYCTGVSAQVQKQRARELGLGRHE---NAIKYLGQDYEQLRVRCLQSGTLFRDE 59
           +  I+P  C    AQ Q+  A E+ + R     N I+Y+      LR R           
Sbjct: 189 QSFISPQSC---DAQGQRYTAEEIEVLRTTSKINGIEYVPFMNVDLRERF---------- 235

Query: 60  AFP-PVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLL 118
           A+P P     G   L P    T+  KW RP +L +NP  I    +   I Q  + DC  +
Sbjct: 236 AYPMPFCDRWGKLPLSPKQKTTFS-KWVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFV 293

Query: 119 AAIA-----SLTLNDTLLHRVV-PHGQSFQNGY--AGIFHFQLWQFGEWVDVVVDDLLPI 170
           A++A         N  L+  ++ P  +  +  Y   G +  +L   G    V++DD LP+
Sbjct: 294 ASLAISAAYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPV 353

Query: 171 KD-GKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRK 229
              G+L+  +S   +E W +L+EKAY KV G Y+   G +++      TG + E   +  
Sbjct: 354 DHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYD-FPGSNSNIDLHALTGWIPERIAMHS 412

Query: 230 -----APSDLYQIILKALERGSLLGCSIDISSVLDMEAITFK-KLVKGHAYSVTGAKQVN 283
                +  + ++++ +   +G +L   I  S+ +  EA   K  LV  HAY+V   ++  
Sbjct: 413 DSQTFSKDNSFRMLYQRFHKGDVL---ITASTGMMTEAEGEKWGLVPTHAYAVLDIRE-- 467

Query: 284 YRGQVVSLIRMRNPWGEVEWTGA--------WSDSSSEWNNVDPYERDQLRVKMEDGEFW 335
           ++G  +  I+++NPW  + W G         W+    ++ N DP    +   K+++G FW
Sbjct: 468 FKG--LRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDP----RTAQKIDNGIFW 521

Query: 336 MSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNP 395
           +S+ D  + +  + + +  P   K        +T    TW       G      +   NP
Sbjct: 522 ISWDDLCQYYDVIYL-SWNPGLFK-------ESTCIHSTW---DAKQGPVKDAYSLANNP 570

Query: 396 QFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQ 455
           Q+K+   E   P        G + V  L+ +H   +  F  + E I   VY+   + V  
Sbjct: 571 QYKL---EVQCP-------QGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVYY 620

Query: 456 PA 457
           PA
Sbjct: 621 PA 622



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 42/162 (25%), Positives = 64/162 (39%), Gaps = 42/162 (25%)

Query: 354 TPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDR 413
           +P  L  R   KW+          G +AGGC N+  T   NP ++  +++T         
Sbjct: 684 SPYTLSKRINGKWS----------GQSAGGCGNFQETHKNNPIYQFHIEKTGP------- 726

Query: 414 ESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRAR 473
                     +    R  R++     ++GF V  V    +G P  H     FL  +S   
Sbjct: 727 ----------LLIELRGPRQY-----SVGFEVVTV--STLGDPGPH----GFLRKSSGDY 765

Query: 474 SEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFS 515
              F  L   +    +P G + ++PSTF P +EG F L F S
Sbjct: 766 RCGFCYLELEN----IPSGIFNIIPSTFLPKQEGPFFLDFNS 803


>gi|38679884 sorcin isoform b [Homo sapiens]
          Length = 183

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 55/164 (33%), Positives = 90/164 (54%), Gaps = 8/164 (4%)

Query: 551 FRQLAGEDMEISVKELRTILNR--IISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLV 608
           F  +AG+D +I   EL+  L +  I   +K      F+LE+CR MV+++DRD +G +G  
Sbjct: 24  FAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCRLMVSMLDRDMSGTMGFN 78

Query: 609 EFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDL 668
           EF  LW  +  +   F  FD D+SG++   E++ A+ + GF+L+ +    I  RYS  + 
Sbjct: 79  EFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYS-TNG 137

Query: 669 AVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTM 712
            + FD+++ C V+L  +   F+  DT   GVV F    ++Q  M
Sbjct: 138 KITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVM 181


>gi|4507207 sorcin isoform a [Homo sapiens]
          Length = 198

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 55/164 (33%), Positives = 90/164 (54%), Gaps = 8/164 (4%)

Query: 551 FRQLAGEDMEISVKELRTILNR--IISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLV 608
           F  +AG+D +I   EL+  L +  I   +K      F+LE+CR MV+++DRD +G +G  
Sbjct: 39  FAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCRLMVSMLDRDMSGTMGFN 93

Query: 609 EFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDL 668
           EF  LW  +  +   F  FD D+SG++   E++ A+ + GF+L+ +    I  RYS  + 
Sbjct: 94  EFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYS-TNG 152

Query: 669 AVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTM 712
            + FD+++ C V+L  +   F+  DT   GVV F    ++Q  M
Sbjct: 153 KITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVM 196


>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
           sapiens]
          Length = 217

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 54/162 (33%), Positives = 86/162 (53%), Gaps = 4/162 (2%)

Query: 551 FRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEF 610
           F  +AG+D E+  +EL+  L +      +     FSLE+CR M+ ++DRD  GK+G   F
Sbjct: 58  FSAVAGQDGEVDAEELQRCLTQ---SGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAF 114

Query: 611 NILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAV 670
             LW  +  +   F   D D SG++  +E+R AI   G++L+ +    I+ RYS+ +  +
Sbjct: 115 KELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSK-NGRI 173

Query: 671 DFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTM 712
            FD++V C V+L  +  FF+  D    G   F    +LQ TM
Sbjct: 174 FFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215


>gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]
          Length = 284

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 40/153 (26%), Positives = 84/153 (54%), Gaps = 9/153 (5%)

Query: 561 ISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNY 620
           IS+KEL+  L        +     F+ E+C  M+N+ D+  +G++ +  F+ LW  I+ +
Sbjct: 134 ISMKELKQAL-------VNCNWSSFNDETCLMMINMFDKTKSGRIDVYGFSALWKFIQQW 186

Query: 621 LSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRY--SEPDLAVDFDNFVCC 678
            ++F+++D D+SGS+S  E++ A+   G+ L+ +  +L+++RY     + A+  D F+  
Sbjct: 187 KNLFQQYDRDRSGSISYTELQQALSQMGYNLSPQFTQLLVSRYCPRSANPAMQLDRFIQV 246

Query: 679 LVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLT 711
             +L+ +   F+  DT + G +      ++ +T
Sbjct: 247 CTQLQVLTEAFREKDTAVQGNIRLSFEDFVTMT 279


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,784,087
Number of Sequences: 37866
Number of extensions: 1193433
Number of successful extensions: 2974
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 2777
Number of HSP's gapped (non-prelim): 126
length of query: 714
length of database: 18,247,518
effective HSP length: 109
effective length of query: 605
effective length of database: 14,120,124
effective search space: 8542675020
effective search space used: 8542675020
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.