Search of human proteins with 27765074

Search of human proteins with 27765074

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27765074 calpain 3 isoform c [Homo sapiens]
         (729 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27765074 calpain 3 isoform c [Homo sapiens]                       1520   0.0  
gi|27765072 calpain 3 isoform b [Homo sapiens]                       1478   0.0  
gi|4557405 calpain 3 isoform a [Homo sapiens]                        1476   0.0  
gi|47078247 calpain 3 isoform f [Homo sapiens]                       1267   0.0  
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                         814   0.0  
gi|12408656 calpain 1, large subunit [Homo sapiens]                   784   0.0  
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                         779   0.0  
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       737   0.0  
gi|221554549 calpain 8 [Homo sapiens]                                 723   0.0  
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       710   0.0  
gi|215490104 calpain 11 [Homo sapiens]                                703   0.0  
gi|27765076 calpain 3 isoform d [Homo sapiens]                        526   e-149
gi|38707981 calpain 12 [Homo sapiens]                                 508   e-144
gi|223468608 calpain 14 [Homo sapiens]                                475   e-134
gi|37577157 calpain 5 [Homo sapiens]                                  383   e-106
gi|41152101 calpain 13 [Homo sapiens]                                 330   3e-90
gi|27765080 calpain 3 isoform e [Homo sapiens]                        329   5e-90
gi|27765078 calpain 3 isoform e [Homo sapiens]                        329   5e-90
gi|13186316 calpain 6 [Homo sapiens]                                  313   4e-85
gi|4502565 calpain, small subunit 1 [Homo sapiens]                    223   4e-58
gi|51599151 calpain, small subunit 1 [Homo sapiens]                   223   4e-58
gi|13186302 calpain 10 isoform a [Homo sapiens]                       220   4e-57
gi|89353291 calpain 10 isoform c [Homo sapiens]                       213   4e-55
gi|14161692 calpain small subunit 2 [Homo sapiens]                    209   1e-53
gi|5032105 small optic lobes [Homo sapiens]                           167   4e-41
gi|38679884 sorcin isoform b [Homo sapiens]                           102   1e-21
gi|4507207 sorcin isoform a [Homo sapiens]                            102   1e-21
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap...    97   7e-20
gi|7656959 calpain 7 [Homo sapiens]                                    92   2e-18
gi|7019485 programmed cell death 6 [Homo sapiens]                      80   7e-15

>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score = 1520 bits (3935), Expect = 0.0
 Identities = 729/729 (100%), Positives = 729/729 (100%)

Query: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
           MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT
Sbjct: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
           FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120

Query: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
           ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD
Sbjct: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180

Query: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
           CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE
Sbjct: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240

Query: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKG 300
           IRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKG
Sbjct: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKG 300

Query: 301 EKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHF 360
           EKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHF
Sbjct: 301 EKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHF 360

Query: 361 TKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEED 420
           TKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEED
Sbjct: 361 TKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEED 420

Query: 421 DDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYN 480
           DDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYN
Sbjct: 421 DDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYN 480

Query: 481 ASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTI 540
           ASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTI
Sbjct: 481 ASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTI 540

Query: 541 SVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 600
           SVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF
Sbjct: 541 SVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 600

Query: 601 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 660
           TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN
Sbjct: 601 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 660

Query: 661 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 720
           DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL
Sbjct: 661 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 720

Query: 721 EWLQLTMYA 729
           EWLQLTMYA
Sbjct: 721 EWLQLTMYA 729


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score = 1478 bits (3827), Expect = 0.0
 Identities = 729/815 (89%), Positives = 729/815 (89%), Gaps = 86/815 (10%)

Query: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
           MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT
Sbjct: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
           FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120

Query: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
           ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD
Sbjct: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180

Query: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
           CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE
Sbjct: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240

Query: 241 IRDAPSDMYKIMKKAIERGSLMGCSID--------------------------------- 267
           IRDAPSDMYKIMKKAIERGSLMGCSID                                 
Sbjct: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300

Query: 268 ---------------TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 312
                          TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW
Sbjct: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360

Query: 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 372
           GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA
Sbjct: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420

Query: 373 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 432
           LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF
Sbjct: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480

Query: 433 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 492
           LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM
Sbjct: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540

Query: 493 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV------ 546
           REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV      
Sbjct: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVPIIFVS 600

Query: 547 --------------------------------PQPGSSDQESEEQQQFRNIFKQIAGDDM 574
                                           PQPGSSDQESEEQQQFRNIFKQIAGDDM
Sbjct: 601 DRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDM 660

Query: 575 EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 634
           EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA
Sbjct: 661 EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 720

Query: 635 WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 694
           WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF
Sbjct: 721 WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 780

Query: 695 VRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729
           VRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 781 VRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 815


>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score = 1476 bits (3821), Expect = 0.0
 Identities = 729/821 (88%), Positives = 729/821 (88%), Gaps = 92/821 (11%)

Query: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60
           MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT
Sbjct: 1   MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT 60

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120
           FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD
Sbjct: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD 120

Query: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180
           ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD
Sbjct: 121 ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD 180

Query: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240
           CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE
Sbjct: 181 CLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFE 240

Query: 241 IRDAPSDMYKIMKKAIERGSLMGCSID--------------------------------- 267
           IRDAPSDMYKIMKKAIERGSLMGCSID                                 
Sbjct: 241 IRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQ 300

Query: 268 ---------------TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 312
                          TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW
Sbjct: 301 DSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPW 360

Query: 313 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 372
           GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA
Sbjct: 361 GQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADA 420

Query: 373 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 432
           LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF
Sbjct: 421 LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSF 480

Query: 433 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 492
           LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM
Sbjct: 481 LVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINM 540

Query: 493 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV------ 546
           REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV      
Sbjct: 541 REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK 600

Query: 547 --------------------------------------PQPGSSDQESEEQQQFRNIFKQ 568
                                                 PQPGSSDQESEEQQQFRNIFKQ
Sbjct: 601 PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 660

Query: 569 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 628
           IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL
Sbjct: 661 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHL 720

Query: 629 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 688
           WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD
Sbjct: 721 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 780

Query: 689 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729
           SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 781 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score = 1267 bits (3279), Expect = 0.0
 Identities = 626/712 (87%), Positives = 626/712 (87%), Gaps = 86/712 (12%)

Query: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163
           EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF
Sbjct: 17  EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 76

Query: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223
           HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN
Sbjct: 77  HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 136

Query: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSID---------------- 267
           TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSID                
Sbjct: 137 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 196

Query: 268 --------------------------------TIIPVQYETRMACGLVRGHAYSVTGLDE 295
                                           TIIPVQYETRMACGLVRGHAYSVTGLDE
Sbjct: 197 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 256

Query: 296 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 355
           VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED
Sbjct: 257 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 316

Query: 356 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 415
           FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK
Sbjct: 317 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 376

Query: 416 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 475
           LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD
Sbjct: 377 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKD 436

Query: 476 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 535
           FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE
Sbjct: 437 FFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEE 496

Query: 536 VENTISVDRPV--------------------------------------PQPGSSDQESE 557
           VENTISVDRPV                                      PQPGSSDQESE
Sbjct: 497 VENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE 556

Query: 558 EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS 617
           EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS
Sbjct: 557 EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS 616

Query: 618 GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR 677
           GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR
Sbjct: 617 GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR 676

Query: 678 YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729
           YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 677 YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score =  814 bits (2102), Expect = 0.0
 Identities = 386/713 (54%), Positives = 517/713 (72%), Gaps = 33/713 (4%)

Query: 18  RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75
           R+PGP  HP    A  T + G                      ++FEQ+ ++CL++  L+
Sbjct: 6   RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43

Query: 76  VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135
            D +FP   +SLFYS++  I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 44  EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103

Query: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195
           A LTLNQ  L RVIP DQSF   YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S 
Sbjct: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163

Query: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255
             NEFWSALLEKAYAKL+GSYEALKGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223

Query: 256 IERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQV 315
           ++RGSL+GC IDT    + E R   GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQV
Sbjct: 224 LKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQV 283

Query: 316 EWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQS 375
           EWNGSWSD   +W  V   E+ RL H   +DGEFWM+++DF  HF K+EICNLT DAL+ 
Sbjct: 284 EWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEE 343

Query: 376 DKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVA 435
           D +  W V+V++G WVRG +AGGCRNF DTFWTNPQ +L L E+D+  ++    CSFLVA
Sbjct: 344 DAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVA 399

Query: 436 LMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREV 495
           LMQK+RRK ++ GA++ TIG+AIYE P +     +HL KDFF Y+AS+ARSKT+IN+REV
Sbjct: 400 LMQKDRRKLKRFGANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREV 455

Query: 496 SQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRP-VPQPGSSDQ 554
           S RF+LPP EY+++PST+EPHQE +F LR+FSEK+ ++ +++  + +D P  P+P   DQ
Sbjct: 456 SDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQ 515

Query: 555 ESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDT 614
           E+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMDT
Sbjct: 516 ETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDT 575

Query: 615 DGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDII 674
            G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +I
Sbjct: 576 SGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLI 635

Query: 675 TMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 727
            +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ LTM
Sbjct: 636 VLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 688


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  784 bits (2024), Expect = 0.0
 Identities = 376/678 (55%), Positives = 501/678 (73%), Gaps = 14/678 (2%)

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
           +EQL  +CL+   L+ D  FPP   SL Y    P         WKRP E+  NP+FI+DG
Sbjct: 42  YEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDG 101

Query: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
           A RTDICQG LGDCW LAAIA LTLN  LL RV+PH QSF   YAGIFHFQ W++GEWVD
Sbjct: 102 ATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVD 161

Query: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
           VV+DD LP  + +LVF  S   NEFWSALLEKAYAK++GSYEAL GG+T+E  EDFTGGV
Sbjct: 162 VVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGV 221

Query: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDE 295
            E++E+R APSD+Y+I+ KA+ERGSL+GCSID    +  E      LV+GHAYSVTG  +
Sbjct: 222 TEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQ 281

Query: 296 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 355
           V ++G+ V L+R+RNPWG+VEW G+WSD   +W+ VD  E+ +L+ ++ EDGEFWMS+ D
Sbjct: 282 VNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKM-EDGEFWMSFRD 340

Query: 356 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 415
           F+  FT+LEICNLT DAL+S  ++ W  ++ EG W RG +AGGCRN+P TFW NPQ++++
Sbjct: 341 FMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIR 400

Query: 416 LLEEDDDPD---DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-H 471
            L+E DDPD   D E  CSF++ALMQK+RR++R+ G  + TIGFA+YEVP E+ G    H
Sbjct: 401 -LDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVH 459

Query: 472 LQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRN 531
           L++DFFL NAS+ARS+ +IN+REVS RFRLPP EYV+VPST+EP++EG+F+LR FSEK  
Sbjct: 460 LKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSA 519

Query: 532 LSEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNK 591
            + E+++ I  + P  Q  S   E E  + F+ +F+Q+AG+DMEI   EL+ +LN +++K
Sbjct: 520 GTVELDDQIQANLPDEQVLS---EEEIDENFKALFRQLAGEDMEISVKELRTILNRIISK 576

Query: 592 HKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTIN 651
           HKDL+T GF+LESCRSM+ LMD DG+GKL L EF+ LWN+I+ +  IF+ +D D+SG+++
Sbjct: 577 HKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMS 636

Query: 652 SYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDG 711
           +YEMR A+  AGF LN +LY++I  RY++  + +DFD+F+CC VRLE MFR F   D D 
Sbjct: 637 AYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDL 696

Query: 712 DGIIKLNVLEWLQLTMYA 729
           DG++  ++ +WLQLTM+A
Sbjct: 697 DGVVTFDLFKWLQLTMFA 714


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score =  779 bits (2012), Expect = 0.0
 Identities = 376/713 (52%), Positives = 504/713 (70%), Gaps = 59/713 (8%)

Query: 18  RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75
           R+PGP  HP    A  T + G                      ++FEQ+ ++CL++  L+
Sbjct: 6   RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43

Query: 76  VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135
            D +FP   +SLFYS++  I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 44  EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103

Query: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195
           A LTLNQ  L RVIP DQSF   YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF  S 
Sbjct: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163

Query: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255
             NEFWSALLEKAYAKL+GSYEALKGG+  EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223

Query: 256 IERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQV 315
           ++RGSL+GC IDT    + E R   GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQV
Sbjct: 224 LKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQV 283

Query: 316 EWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQS 375
           EWNGSWSDR                          M+++DF  HF K+EICNLT DAL+ 
Sbjct: 284 EWNGSWSDR--------------------------MAFKDFKAHFDKVEICNLTPDALEE 317

Query: 376 DKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVA 435
           D +  W V+V++G WVRG +AGGCRNF DTFWTNPQ +L L E+D+  ++    CSFLVA
Sbjct: 318 DAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVA 373

Query: 436 LMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREV 495
           LMQK+RRK ++ GA++ TIG+AIYE P +     +HL KDFF Y+AS+ARSKT+IN+REV
Sbjct: 374 LMQKDRRKLKRFGANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREV 429

Query: 496 SQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRP-VPQPGSSDQ 554
           S RF+LPP EY+++PST+EPHQE +F LR+FSEK+ ++ +++  + +D P  P+P   DQ
Sbjct: 430 SDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQ 489

Query: 555 ESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDT 614
           E+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC+++I+LMDT
Sbjct: 490 ETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDT 549

Query: 615 DGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDII 674
            G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF L++ L  +I
Sbjct: 550 SGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLI 609

Query: 675 TMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 727
            +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ LTM
Sbjct: 610 VLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 662


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  737 bits (1903), Expect = 0.0
 Identities = 347/669 (51%), Positives = 478/669 (71%), Gaps = 11/669 (1%)

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
           +E L  +CLE   L+ DP FP   ++L + +  P         WKRP EIC +P+FII G
Sbjct: 32  YEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGG 91

Query: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
           A RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIFHFQFW+YGEWV+
Sbjct: 92  ATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVE 151

Query: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
           VV+DD LPT + +L+F  S   +EFWSALLEKAYAK++G YEAL GG TTE  EDFTGG+
Sbjct: 152 VVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGI 211

Query: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDE 295
           AE++E++  P +++KI++KA+++GSL+GCSID       E      LV+GHAYSVTG +E
Sbjct: 212 AEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEE 271

Query: 296 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 355
           V   G   KL+R+RNPWG+VEW G W+D    W+ +D +E+ RL  +  EDGEFWMS+ D
Sbjct: 272 VESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSD 330

Query: 356 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 415
           F+ H+++LEICNLT D L SD  + W ++  +G W RG +AGGCRN+P+TFW NPQY +K
Sbjct: 331 FLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIK 390

Query: 416 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQK 474
           L EED+D +D E  C+FLV L+QK+RR+ RK+G  + TIGF IYEVP+E+ G    HL K
Sbjct: 391 LEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSK 450

Query: 475 DFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSE 534
           +FFL N ++ RS T+IN+REV  RF+LPP EY++VPST+EP+++G+F +RVFSEK+   +
Sbjct: 451 NFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQ 510

Query: 535 EVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKD 594
            V++ I  +           E +    FR +F Q+AG+D EI A EL+ +L  V+ K +D
Sbjct: 511 AVDDEIEAN----LEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQD 566

Query: 595 LKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYE 654
           +K+ GF++E+C+ M+ ++D+DGSGKL L+EF+ LW KI+ +QKI++  D D+SGT+NSYE
Sbjct: 567 IKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYE 626

Query: 655 MRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGI 714
           MR A+ +AGF +  QL+ +I  R+AD  + IDFD+F+ C VRLE +F+ F   D +  G 
Sbjct: 627 MRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGT 686

Query: 715 IKLNVLEWL 723
           I+L+++ WL
Sbjct: 687 IELDLISWL 695


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  723 bits (1866), Expect = 0.0
 Identities = 342/671 (50%), Positives = 479/671 (71%), Gaps = 12/671 (1%)

Query: 61  FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFIIDG 115
           F+ L ++CL+  VL+ DPEFP   ++L Y    P        +WKRP E+C +P+FI+ G
Sbjct: 32  FKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIVGG 91

Query: 116 ANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVD 175
           A RTDICQG LGDCW LAAIA LTLN+ LL+RV+P DQ F ENYAGIFHFQFW+YGEWV+
Sbjct: 92  ATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEWVE 151

Query: 176 VVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGV 235
           VVIDD LPT N QL+F  S   NEFWSALLEKAYAKL+G YEAL GG+T E  EDFTGG+
Sbjct: 152 VVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGI 211

Query: 236 AEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDE 295
           +EF++++  P+++Y+I++KA+  GSL+GCSID     + E   +  LV+ HAYSVTG++E
Sbjct: 212 SEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTGVEE 271

Query: 296 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 355
           V F+G   KL+RLRNPWG+VEW+G+WSD   +W+ +D   K  L  +V EDGEFWMS  D
Sbjct: 272 VNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKV-EDGEFWMSLSD 330

Query: 356 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 415
           F+  F++LEICNL+ D+L S+++  W + +  G W RG +AGGC+N+P T+WTNPQ++++
Sbjct: 331 FVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIR 390

Query: 416 LLEEDDDPDDS--EVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HL 472
           L E D+D ++S  E  C+ L+ LMQKNRR  +++G  + +IG+A+Y+VPKE+  +   HL
Sbjct: 391 LDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHL 450

Query: 473 QKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNL 532
            +DFFL     AR+ TY+N+REVS R RLPP EY++VPST+EP ++GEF LRVFSEK+  
Sbjct: 451 GRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQ 510

Query: 533 SEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKH 592
           + E+ + ++ +   P P   DQE +   QFR +F+++AG D EI A+ LK +LN   +K 
Sbjct: 511 ALEIGDVVAGNPYEPHPSEVDQEDD---QFRRLFEKLAGKDSEITANALKILLNEAFSKR 567

Query: 593 KDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINS 652
            D+K  GF + +CR MI+L+D++G+G L   EF  LW KI+ + +I+   D + SGTI++
Sbjct: 568 TDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDA 627

Query: 653 YEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGD 712
           +EMR A+  AGF LN+Q+   I +RYA   + I+FDSF+ C +RLE +F+ F   D+D D
Sbjct: 628 HEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKD 687

Query: 713 GIIKLNVLEWL 723
           G+++L++ EWL
Sbjct: 688 GMVQLSLAEWL 698


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  710 bits (1832), Expect = 0.0
 Identities = 331/621 (53%), Positives = 455/621 (73%), Gaps = 6/621 (0%)

Query: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163
           EIC +P+FII GA RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIF
Sbjct: 2   EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61

Query: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223
           HFQFW+YGEWV+VV+DD LPT + +L+F  S   +EFWSALLEKAYAK++G YEAL GG 
Sbjct: 62  HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121

Query: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLV 283
           TTE  EDFTGG+AE++E++  P +++KI++KA+++GSL+GCSID       E      LV
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181

Query: 284 RGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQV 343
           +GHAYSVTG +EV   G   KL+R+RNPWG+VEW G W+D    W+ +D +E+ RL  + 
Sbjct: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR- 240

Query: 344 TEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFP 403
            EDGEFWMS+ DF+ H+++LEICNLT D L SD  + W ++  +G W RG +AGGCRN+P
Sbjct: 241 HEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYP 300

Query: 404 DTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPK 463
           +TFW NPQY +KL EED+D +D E  C+FLV L+QK+RR+ RK+G  + TIGF IYEVP+
Sbjct: 301 NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE 360

Query: 464 EMHGNKQ-HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFI 522
           E+ G    HL K+FFL N ++ RS T+IN+REV  RF+LPP EY++VPST+EP+++G+F 
Sbjct: 361 ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC 420

Query: 523 LRVFSEKRNLSEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELK 582
           +RVFSEK+   + V++ I  +           E +    FR +F Q+AG+D EI A EL+
Sbjct: 421 IRVFSEKKADYQAVDDEIEAN----LEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQ 476

Query: 583 KVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHY 642
            +L  V+ K +D+K+ GF++E+C+ M+ ++D+DGSGKL L+EF+ LW KI+ +QKI++  
Sbjct: 477 TILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREI 536

Query: 643 DTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFR 702
           D D+SGT+NSYEMR A+ +AGF +  QL+ +I  R+AD  + IDFD+F+ C VRLE +F+
Sbjct: 537 DVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFK 596

Query: 703 AFHAFDKDGDGIIKLNVLEWL 723
            F   D +  G I+L+++ WL
Sbjct: 597 IFKQLDPENTGTIELDLISWL 617


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  703 bits (1815), Expect = 0.0
 Identities = 351/679 (51%), Positives = 464/679 (68%), Gaps = 13/679 (1%)

Query: 59  KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFP----IQFV-WKRPPEICENPRFII 113
           ++FE+L   CL K  L+ DP FP + +SL +    P    +Q + W+RP +I  NP FI+
Sbjct: 64  QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123

Query: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173
           DG + TDICQG LGDCW LAAI  LT    LL+RV+P  QSF +NYAGIFHFQ W++G+W
Sbjct: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183

Query: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
           V+VV+DD LPT N++LVF  S  R+EFWSALLEKAYAKL GSYEAL GG+T E +EDFTG
Sbjct: 184 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTG 243

Query: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGL 293
           GVA+ F+++  P ++ ++++KA+ER SLMGCSI+     + E+     LVRGHAYSVTGL
Sbjct: 244 GVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGL 303

Query: 294 DEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSY 353
            +V ++G+   L+R+RNPWG++EWNG+WSD  ++W  V  D + +L H+ TEDGEFWMSY
Sbjct: 304 QDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHK-TEDGEFWMSY 362

Query: 354 EDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYR 413
           +DF+ +FT LEICNLT D L  D    W  +  EG W RG SAGGCRN P TFWTNPQ++
Sbjct: 363 QDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFK 422

Query: 414 LKLLEEDDDPDDSE---VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ 470
           + L E DD  DD+E   V+C+ LVALMQKN R  R+ GA L TIGF +Y VPKE    + 
Sbjct: 423 ISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQD 482

Query: 471 -HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEK 529
            HL+K+FF        S+ + N REVS + RLPP EY+I+PST+EPH++ +F+LRVF+EK
Sbjct: 483 VHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEK 542

Query: 530 RNLSEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVV 589
            + S E++     ++   +  S D   +  Q F ++FK +AG+  EI   EL+++LN + 
Sbjct: 543 HSESWELDEVNYAEQLQEEKVSED---DMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMA 599

Query: 590 NKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGT 649
            K K  KT GF L++CR MI LMD DGSGKL L EF  LW K+K W  IF+  D D SGT
Sbjct: 600 IKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGT 659

Query: 650 INSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDK 709
           +NSYEMR  +  AG  LNN++  ++  RYAD  + IDFDSFI CF+RL+ MF  F   D 
Sbjct: 660 LNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDP 719

Query: 710 DGDGIIKLNVLEWLQLTMY 728
              G I L++ +WLQ+TM+
Sbjct: 720 KNTGHICLSLEQWLQMTMW 738


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score =  526 bits (1355), Expect = e-149
 Identities = 265/309 (85%), Positives = 265/309 (85%), Gaps = 44/309 (14%)

Query: 465 MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 524
           MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR
Sbjct: 1   MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 60

Query: 525 VFSEKRNLSEEVENTISVDRPV-------------------------------------- 546
           VFSEKRNLSEEVENTISVDRPV                                      
Sbjct: 61  VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 120

Query: 547 ------PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 600
                 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF
Sbjct: 121 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 180

Query: 601 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 660
           TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN
Sbjct: 181 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 240

Query: 661 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 720
           DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL
Sbjct: 241 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 300

Query: 721 EWLQLTMYA 729
           EWLQLTMYA
Sbjct: 301 EWLQLTMYA 309


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  508 bits (1308), Expect = e-144
 Identities = 275/701 (39%), Positives = 402/701 (57%), Gaps = 41/701 (5%)

Query: 59  KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQ-----FVWKRPPEICENPRFII 113
           +++E +   CL+  +L+ DP FP    +L Y Q  P         W RP E C  P+FI 
Sbjct: 30  QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFIC 89

Query: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173
           +  +RTD+CQG LG+CWFLAA A LTL   LL RV+P  Q F   YAG+FHFQ W++G W
Sbjct: 90  EDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFGRW 149

Query: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
           +DVV+DD LP    +L+F +S  RNEFW+ LLEKAYAKLHGSYE ++GG+  EA  DFTG
Sbjct: 150 MDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTG 209

Query: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGL 293
           GV E   +R     ++  ++ A+ + SL+G    T +  + E R   GLV+GHAYS+TG 
Sbjct: 210 GVGEVLYLRQNSMGLFSALRHALAKESLVGA---TALSDRGEYRTEEGLVKGHAYSITGT 266

Query: 294 DEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSY 353
            +V     KV+L+RLRNPWG VEW G+WSD    W  +  + +  L  +  EDGEFWM  
Sbjct: 267 HKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVK-KEDGEFWMEL 325

Query: 354 EDFIYHFTKLEICNLTADAL-QSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQY 412
            DF+ HF  ++IC+L+ + L  S +   W V   +GRWVRG ++GG +   +TFWTNPQ+
Sbjct: 326 RDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQF 385

Query: 413 RLKLLEEDDDPDDSE---------------------VICSFLVALMQKNRRKDRKLGASL 451
           RL LLE D++ D+ E                       C+ L++L+Q+NRR+ R  G + 
Sbjct: 386 RLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTY 445

Query: 452 FTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPS 511
            T+GF ++++P+E+ G     +    L    +A        R+V++R  L P  Y++VPS
Sbjct: 446 LTVGFHVFQIPEELLGLWDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPS 505

Query: 512 TYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAG 571
           T     E +F LRVFSE+R+ + E+++ IS D    Q      E   +Q    +F+++AG
Sbjct: 506 TAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLPLELGLEQ----LFQELAG 561

Query: 572 DDMEICADELKKVLNTVVNKHKDLKTHGFTLE--SCRSMIALMDTDGSGK-LNLQEFHHL 628
           ++ E+ A +L+ +L+  +   +  + H  T      R+   L+   G G+ L L  F  L
Sbjct: 562 EEEELNASQLQALLSIAL---EPARAHTSTPREIGLRTCEQLLQCFGHGQSLALHHFQQL 618

Query: 629 WNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFD 688
           W  +  WQ IF  +D D SGT+NSYE+R A+N AGFHLNNQL   +T RY D  + +DF+
Sbjct: 619 WGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRVDFE 678

Query: 689 SFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729
            F+ C   L  +F         G+G+I L   +W+++  ++
Sbjct: 679 RFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  475 bits (1222), Expect = e-134
 Identities = 270/677 (39%), Positives = 382/677 (56%), Gaps = 24/677 (3%)

Query: 58  EKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYS---QKFPIQFVWKRPPEICENPRFIID 114
           ++ FE L  +CL    L+ D  FP   +S+      QK P +  WKRPPE+  NP+F   
Sbjct: 27  QQDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFA 86

Query: 115 GANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWV 174
            A R D+CQG +GDCWFLAA+  L L+Q +L RV+P +QSF E YAGIF F FW YG WV
Sbjct: 87  KAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWV 146

Query: 175 DVVIDDCLPTYN-NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
            VVIDD LP     QLVF  S ++N FW ALLEKAYAKL GSYE L+ G  +EA+ DFTG
Sbjct: 147 PVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTG 206

Query: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGL 293
           GV     + +A  +++ I+ +A    +L+GC   +      E  +  GLV GHAY++TG+
Sbjct: 207 GVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHS-----GEKILENGLVEGHAYTLTGI 261

Query: 294 DEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSY 353
            +V  K     LV+LRNPWG+VEW G WSD    W  +   EK  L  +   DGEFWM+ 
Sbjct: 262 RKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRK-DNDGEFWMTL 320

Query: 354 EDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRN-FPDTFWTNPQY 412
           +DF  HF  L IC LT   L  +  Q WT ++ EGRW +  +AGG R    DTFW NPQ+
Sbjct: 321 QDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQF 380

Query: 413 RLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHL 472
            L +   ++        CS LV+L+QK R + RK    L  IGF +Y + K  H +++ L
Sbjct: 381 LLSVWRPEEGRRSLRP-CSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNK-YHDDQRRL 437

Query: 473 QKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNL 532
             +FF  N   ++   ++  +EVSQ   L P  Y+IVP   E HQ+ EF+LRVFS K   
Sbjct: 438 PPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHIF 497

Query: 533 SEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKH 592
            E     I  +  V      + ++E Q +F   F +      EI A +L+ +LN +    
Sbjct: 498 YE-----IGSNSGVVFSKEIEDQNERQDEF---FTKFFEKHPEINAVQLQNLLNQMTWSS 549

Query: 593 KDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINS 652
              +   F+LE+C+ ++AL+D + SG +++QEF  LW ++K  QK+F H     SG +N 
Sbjct: 550 LGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVF-HKQDRGSGYLNW 608

Query: 653 YEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGD 712
            ++  A+ +AG  L++ +  ++ +RY    + +DF SFI   +R+E M   F    +DG 
Sbjct: 609 EQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGK 668

Query: 713 GIIKLNVLEWLQLTMYA 729
           GI  L   EW+ + +Y+
Sbjct: 669 GIY-LQKPEWMMMALYS 684


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  383 bits (983), Expect = e-106
 Identities = 210/500 (42%), Positives = 286/500 (57%), Gaps = 46/500 (9%)

Query: 57  KEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGA 116
           +++ +  L + C  +KVL+ DP FP  + SL+Y         WKRP  ICE+PR  +DG 
Sbjct: 9   EDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGI 68

Query: 117 NRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHFQFWRY 170
           +  D+ QG++G+CWF+AA + L   + L  +VIP       D      YAGIFHF FWR+
Sbjct: 69  SSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRF 128

Query: 171 GEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMED 230
           GEWVDVVIDD LPT NNQL++  SN RNEFW AL+EKAYAKL G Y+AL GGNT +A+ D
Sbjct: 129 GEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVD 188

Query: 231 FTGGVAEFFEIRDAP--------SDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGL 282
           FTGGV+E  ++ +          + +++ M K   RG L+  SI  +     E R+ACGL
Sbjct: 189 FTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGL 248

Query: 283 VRGHAYSVTGLDEVP--------FKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKD 334
           V+GHAY+VT + +V         FK EK+ ++RLRNPWG+ EWNG WSD  ++W  V K 
Sbjct: 249 VKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKS 308

Query: 335 EKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWV--- 391
           E+ ++   V +DGEFWM++ED   +FT +  C +   +  S   +TW  +   G W    
Sbjct: 309 EREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIH-KTWEEARLHGAWTLHE 367

Query: 392 --RGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG- 448
             R    GGC N  DTF+ NPQY    + E   P+D  +IC     + Q+ +R  R+ G 
Sbjct: 368 DPRQNRGGGCINHKDTFFQNPQY----IFEVKKPEDEVLIC-----IQQRPKRSTRREGK 418

Query: 449 ASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVI 508
                IGF IY+V +        LQ         KA S  YIN R V  R   P   YVI
Sbjct: 419 GENLAIGFDIYKVEENRQYRMHSLQ--------HKAASSIYINSRSVFLRTDQPEGRYVI 470

Query: 509 VPSTYEPHQEGEFILRVFSE 528
           +P+T+EP   GEF+LRVF++
Sbjct: 471 IPTTFEPGHTGEFLLRVFTD 490


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  330 bits (846), Expect = 3e-90
 Identities = 217/691 (31%), Positives = 348/691 (50%), Gaps = 50/691 (7%)

Query: 53  IIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSL---FYSQKFPIQFVWKRPPEICENP 109
           II  K++ F  L   CL     + D  FP  ++S+      +K     +WKRP ++   P
Sbjct: 13  IIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGP 72

Query: 110 -RFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFW 168
             FI+D  +R DI QG   DCWFLAA+  LT N     +++   QSF   YAGIF F+FW
Sbjct: 73  PHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFW 131

Query: 169 RYGEWVDVVIDDCLPTYNNQLVFTKSNHRN-EFWSALLEKAYAKLHGSYEALKGGNTTEA 227
           + G+WV+VVIDD LP   ++ +F +  H+N EFW  LLEKAYAKL GSY  L  G   +A
Sbjct: 132 QCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDA 191

Query: 228 MEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHA 287
           + D TGGV     +  +P D+ K +K A + GSL+ C+  +  P      M  GLV  HA
Sbjct: 192 LVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPS-GPTDTAQAMENGLVSLHA 250

Query: 288 YSVTGLDEVPFKGEKVKLVRLRNP--WGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTE 345
           Y+VTG +++ ++    +++ L NP  WG+ EW G WSD  ++W       K++L H+  E
Sbjct: 251 YTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQL-HKKRE 309

Query: 346 DGEFWMSYEDFIYHFTKLEICNLTADALQSDKL--QTWTVSVNEGRWVRGCSAGGCRNFP 403
           DGEFWMS +DF   F  + IC+     L       + W+  +   + + G +AGG RN  
Sbjct: 310 DGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN-- 367

Query: 404 DTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPK 463
                + Q+   + E  +    + V+C  +       + +D K     F + F +     
Sbjct: 368 -----DAQFNFSVQEPME--GTNVVVCVTVAVTPSNLKAEDAK-----FPLDFQVILAGS 415

Query: 464 EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFIL 523
           +    ++     FF    +  +S      R  +  + L P  YV+V  T    +  EF+L
Sbjct: 416 QRF--REKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLL 471

Query: 524 RVFSEKRNLSEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKK 583
           R+F +  +    + +  +    +   GS  +   +Q    +IF + A   ++I A +L+ 
Sbjct: 472 RIFLKMPDSDRHLSSHFN----LRMKGSPSEHGSQQ----SIFNRYAQQRLDIDATQLQG 523

Query: 584 VLN--TVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKH 641
           +LN   +     D+    F+L+ CRS++ALM+   +G+L+ +EF  LW ++  +Q +F+ 
Sbjct: 524 LLNQELLTGPPGDM----FSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQK 579

Query: 642 YDTDQSGTINSYEMRNAVNDA----GFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRL 697
             T   G + S ++  A+ +     G  ++ +L  ++T+RY+D    + F S +C  +RL
Sbjct: 580 VQT-SPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRL 638

Query: 698 EGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 728
           E M + F    KDG G+  L  +EW+ L MY
Sbjct: 639 EAMAKTFRNLSKDGKGLY-LTEMEWMSLVMY 668


>gi|27765080 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  329 bits (844), Expect = 5e-90
 Identities = 156/156 (100%), Positives = 156/156 (100%)

Query: 574 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 633
           MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 634 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 693
           AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 694 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729
           FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|27765078 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  329 bits (844), Expect = 5e-90
 Identities = 156/156 (100%), Positives = 156/156 (100%)

Query: 574 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 633
           MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 634 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 693
           AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 694 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729
           FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score =  313 bits (802), Expect = 4e-85
 Identities = 183/505 (36%), Positives = 279/505 (55%), Gaps = 47/505 (9%)

Query: 52  PIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRF 111
           P+   K + +++L ++C++   L+ DP F P+  SLFY++  P + VWKRP +IC++P  
Sbjct: 4   PLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHL 63

Query: 112 IIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHF 165
           I+   +   + QG LG    ++A +CL + +    + IP+      D    E YAGIFHF
Sbjct: 64  IVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHF 123

Query: 166 QFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTT 225
           +FW +GEW +VVIDD LPT N  LVF+ S   NEFW+ALLEKAYAKL G YEAL G   T
Sbjct: 124 RFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTIT 183

Query: 226 EAMEDFTGGVAEFFEIR-----DAPSDMYKI---MKKAIERGSLMGCSIDTIIPVQYETR 277
           + + DFTG +AE  +++     +   + YK+   + K   +G L+ CSI++    + E  
Sbjct: 184 DIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVE 243

Query: 278 MACGLVRGHAYSVTGLDEV--------PFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWS 329
              GL++GH Y++T + ++         F  EKV +VRLRNP G+ EW+G WS+  ++W 
Sbjct: 244 TDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQ 303

Query: 330 FVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDK-----LQTWTVS 384
            +   ++  L   +++DGEFWMS EDF  +F KL +C    + +   K     L  WTV 
Sbjct: 304 QLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVD 363

Query: 385 VNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKD 444
            ++    R   +GGC N  DTF  NPQY   +      P+D   +   +++L QK+ R  
Sbjct: 364 -DDPLMNR---SGGCYNNRDTFLQNPQYIFTV------PEDGHKV---IMSLQQKDLRTY 410

Query: 445 RKLG-ASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPP 503
           R++G    + IGF +++V         H      LY   +A + TYI+ R V     L  
Sbjct: 411 RRMGRPDNYIIGFELFKVEMNRKFRLHH------LYIQERAGTSTYIDTRTVFLSKYLKK 464

Query: 504 SEYVIVPSTYEPHQEGEFILRVFSE 528
             YV+VP+ ++  +  EF+LR+FSE
Sbjct: 465 GNYVLVPTMFQHGRTSEFLLRIFSE 489


>gi|4502565 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  223 bits (569), Expect = 4e-58
 Identities = 103/175 (58%), Positives = 134/175 (76%)

Query: 555 ESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDT 614
           ESEE +QFR +F Q+AGDDME+ A EL  +LN VV +H DLKT GF +++CRSM+A+MD+
Sbjct: 94  ESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDS 153

Query: 615 DGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDII 674
           D +GKL  +EF +LWN IK WQ I+K +DTD+SGTI S E+  A   AGFHLN  LY++I
Sbjct: 154 DTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMI 213

Query: 675 TMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729
             RY+D+  N+DFD+FI C VRL+ MFRAF + DKDG G I++N+ EWLQLTMY+
Sbjct: 214 IRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 268


>gi|51599151 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  223 bits (569), Expect = 4e-58
 Identities = 103/175 (58%), Positives = 134/175 (76%)

Query: 555 ESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDT 614
           ESEE +QFR +F Q+AGDDME+ A EL  +LN VV +H DLKT GF +++CRSM+A+MD+
Sbjct: 94  ESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDS 153

Query: 615 DGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDII 674
           D +GKL  +EF +LWN IK WQ I+K +DTD+SGTI S E+  A   AGFHLN  LY++I
Sbjct: 154 DTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMI 213

Query: 675 TMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729
             RY+D+  N+DFD+FI C VRL+ MFRAF + DKDG G I++N+ EWLQLTMY+
Sbjct: 214 IRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 268


>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score =  220 bits (560), Expect = 4e-57
 Identities = 160/495 (32%), Positives = 239/495 (48%), Gaps = 55/495 (11%)

Query: 74  LYVDPEFPPDETSLFYSQKFPI-----QFVWKRPPEICENPRFIIDGANRTDICQGELGD 128
           L+ D  FP  ++SLF     P+        W+RP EIC  PR   D      + QG LGD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 129 CWFLAAIACLTLNQHLLFRVIPHDQSFI--ENYAGIFHFQFWRYGEWVDVVIDDCLPTYN 186
           CWFL A A L  ++HLL +VIP  Q     + Y G F  + W++G WV+V  DD LP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 187 NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIR---- 242
            +L F++    + FW  LLEK YAK+HGSYE L  G   +A+ D TGG+AE + ++    
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192

Query: 243 -----DAPSDM-YKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEV 296
                D P    ++  ++ +        S   + P       A  L   HA+ V+ L E+
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSP----RAGARELGEFHAFIVSDLREL 248

Query: 297 PFK-GEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 355
             + G+ + L+R++NPWG+  W G W +  + WS VD    + L  Q+ ++GEFW+  E+
Sbjct: 249 QGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQL-QEGEFWVEEEE 307

Query: 356 FIYHFTKLEICNLTADA-----LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNP 410
           F+  F +L +     +A     L +++L   T ++  G WV+G SAGGCRN    F +NP
Sbjct: 308 FLREFDELTVGYPVTEAGHLQSLYTERLLCHTRAL-PGAWVKGQSAGGCRN-NSGFPSNP 365

Query: 411 QYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRK-LGASLFTIGFAIYEVPKEMHGNK 469
           ++ L++ E       SEV     +A++Q++R       G +   +G +           K
Sbjct: 366 KFWLRVSE------PSEV----YIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGK 415

Query: 470 QHLQKDFFLYNASKAR--------------SKTYINMREVSQRFRLPPSEYVIVPSTYEP 515
            +      L+   K R              +  +   REV  R  L P  Y+ VPST+  
Sbjct: 416 HYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLK 475

Query: 516 HQEGEFILRVFSEKR 530
              GEF+LRVFS  R
Sbjct: 476 DAPGEFLLRVFSTGR 490



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 43/145 (29%), Positives = 60/145 (41%), Gaps = 16/145 (11%)

Query: 381 WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKN 440
           W      G W  G +AGG RNF  ++ TNP +   +      P+     C   + L Q  
Sbjct: 514 WGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV------PEGPGPRC-VRITLHQHC 565

Query: 441 RRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFR 500
           R  D +       IGF I++VP+   G  Q       L          +   +EVS+   
Sbjct: 566 RPSDTEF----HPIGFHIFQVPEG--GRSQDAPP--LLLQEPLLSCVPHRYAQEVSRLCL 617

Query: 501 LPPSEYVIVPSTYEPHQEGEFILRV 525
           LP   Y +VPSTY P  EG F + +
Sbjct: 618 LPAGTYKVVPSTYLPDTEGAFTVTI 642


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  213 bits (543), Expect = 4e-55
 Identities = 158/496 (31%), Positives = 239/496 (48%), Gaps = 65/496 (13%)

Query: 74  LYVDPEFPPDETSLFYSQKFPI-----QFVWKRPPEICENPRFIIDGANRTDICQGELGD 128
           L+ D  FP  ++SLF     P+        W+RP EIC  PR   D      + QG LGD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 129 CWFLAAIACLTLNQHLLFRVIPHDQSFI--ENYAGIFHFQFWRYGEWVDVVIDDCLPTYN 186
           CWFL A A L  ++HLL +VIP  Q     + Y G F  + W++G WV+V  DD LP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132

Query: 187 NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIR---- 242
            +L F++    + FW  LLEK YAK+HGSYE L  G   +A+ D TGG+AE + ++    
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192

Query: 243 -----DAPSDM-YKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEV 296
                D P    ++  ++ +        S   + P       A  L   HA+ V+ L E+
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSP----RAGARELGEFHAFIVSDLREL 248

Query: 297 PFK-GEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 355
             + G+ + L+R++NPWG+  W G W +  + WS VD    + L  Q+ ++GEFW+  E+
Sbjct: 249 QGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQL-QEGEFWVEEEE 307

Query: 356 FIYHFTKLEICNLTADA-----LQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNP 410
           F+  F +L +     +A     L +++L   T ++  G WV+G SAGGCRN    F +NP
Sbjct: 308 FLREFDELTVGYPVTEAGHLQSLYTERLLCHTRAL-PGAWVKGQSAGGCRN-NSGFPSNP 365

Query: 411 QYRLKLLEEDDDPDDSEVICSFLVALMQKNR-------RKDRKL--------------GA 449
           ++ L++ E       SEV     +A++Q++R        + R L              G 
Sbjct: 366 KFWLRVSE------PSEV----YIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGK 415

Query: 450 SLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIV 509
               +G  +++VP+   G  Q       L          +   +EVS+   LP   Y +V
Sbjct: 416 HYQAVGLHLWKVPE--GGRSQDAPP--LLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVV 471

Query: 510 PSTYEPHQEGEFILRV 525
           PSTY P  EG F + +
Sbjct: 472 PSTYLPDTEGAFTVTI 487


>gi|14161692 calpain small subunit 2 [Homo sapiens]
          Length = 248

 Score =  209 bits (531), Expect = 1e-53
 Identities = 93/175 (53%), Positives = 135/175 (77%)

Query: 555 ESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDT 614
           ESEE ++FR  F Q+AG DME+ A +L  +LN V++KHKDLKT GF+L++CRS++++MD+
Sbjct: 74  ESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFSLDTCRSIVSVMDS 133

Query: 615 DGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDII 674
           D +GKL  +EF +LWN IK WQ ++K YD D SG++ S ++R A+  AGF LN QLY +I
Sbjct: 134 DTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMI 193

Query: 675 TMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 729
             RYA++  ++DF++FI C VRL+ MFRAF + D+D DG+I++++ EWLQLTMY+
Sbjct: 194 VRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMYS 248


>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score =  167 bits (422), Expect = 4e-41
 Identities = 113/338 (33%), Positives = 158/338 (46%), Gaps = 31/338 (9%)

Query: 55  GVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQF---VWKRPPEI-CENPR 110
           G  +  +E +   C E  V +VD  FPP   S+ +     +Q     W RP EI C   R
Sbjct: 468 GEAKALWENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFR 527

Query: 111 ------FIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFH 164
                  +      +DI QG LG+CWFL+A+A L     L+ RV+       E   G + 
Sbjct: 528 DHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQ 584

Query: 165 FQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNT 224
            +  + G W  V++DD LP      +      R + W AL+EKA AKLHGSY AL+ G  
Sbjct: 585 VRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRA 644

Query: 225 TEAMEDFTGGVAEFFEI-------RDAPSDMYKIMKKAI---ERGSLMGCSI-DTIIPVQ 273
            E +   TG   E   +       R+ P D   I  K +   E G LMG S     + V 
Sbjct: 645 IEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVD 704

Query: 274 YETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDK 333
                + GL   HAYS+  + +V    +  +L+RLRNPWG+  WNGSWSD W  W     
Sbjct: 705 DSAYESLGLRPRHAYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PG 757

Query: 334 DEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTAD 371
             +  L    + +G FWM Y DF+ +F  ++IC + +D
Sbjct: 758 HLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICKVHSD 795


>gi|38679884 sorcin isoform b [Homo sapiens]
          Length = 183

 Score =  102 bits (255), Expect = 1e-21
 Identities = 57/181 (31%), Positives = 93/181 (51%), Gaps = 8/181 (4%)

Query: 549 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCR 606
           PG      + Q      F  +AG D +I ADEL++ L    +   +K      F LE+CR
Sbjct: 7   PGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCR 61

Query: 607 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 666
            M++++D D SG +   EF  LW  +  W++ F  +DTD+SGT++  E++ A+   GF L
Sbjct: 62  LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRL 121

Query: 667 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 726
           + Q  + I  RY+  +  I FD +I C V+L  +  +F   D    G++     +++Q  
Sbjct: 122 SPQAVNSIAKRYS-TNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCV 180

Query: 727 M 727
           M
Sbjct: 181 M 181


>gi|4507207 sorcin isoform a [Homo sapiens]
          Length = 198

 Score =  102 bits (255), Expect = 1e-21
 Identities = 57/181 (31%), Positives = 93/181 (51%), Gaps = 8/181 (4%)

Query: 549 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCR 606
           PG      + Q      F  +AG D +I ADEL++ L    +   +K      F LE+CR
Sbjct: 22  PGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCR 76

Query: 607 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 666
            M++++D D SG +   EF  LW  +  W++ F  +DTD+SGT++  E++ A+   GF L
Sbjct: 77  LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRL 136

Query: 667 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 726
           + Q  + I  RY+  +  I FD +I C V+L  +  +F   D    G++     +++Q  
Sbjct: 137 SPQAVNSIAKRYS-TNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCV 195

Query: 727 M 727
           M
Sbjct: 196 M 196


>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
           sapiens]
          Length = 217

 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 59/179 (32%), Positives = 88/179 (49%), Gaps = 4/179 (2%)

Query: 549 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSM 608
           P  SD  S         F  +AG D E+ A+EL++ L        +     F+LE+CR M
Sbjct: 41  PAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLT---QSGINGTYSPFSLETCRIM 97

Query: 609 IALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNN 668
           IA++D D +GK+    F  LW  + AW++ F   D D SGT+  +E+R A+   G+ L+ 
Sbjct: 98  IAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSP 157

Query: 669 QLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 727
           Q    I  RY+ K+  I FD ++ C V+L  +   F   D    G       ++LQ TM
Sbjct: 158 QTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215


>gi|7656959 calpain 7 [Homo sapiens]
          Length = 813

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 76/283 (26%), Positives = 139/283 (49%), Gaps = 33/283 (11%)

Query: 99  WKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLT-----LNQHLLFRVI-PHD 152
           W RP ++  NP  I    +   I Q  + DC F+A++A         N+ L+  +I P +
Sbjct: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319

Query: 153 QSFIENY--AGIFHFQFWRYGEWVDVVIDDCLPT-YNNQLVFTKSNHRNEFWSALLEKAY 209
           +     Y   G +  +    G    V+IDD LP  +  +L+ + SN+++E W +L+EKAY
Sbjct: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379

Query: 210 AKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRD-----APSDMYKIMKKAIERGS-LMG 263
            K+ G Y+   G N+   +   TG + E   +       +  + ++++ +   +G  L+ 
Sbjct: 380 MKVMGGYD-FPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLIT 438

Query: 264 CSIDTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSD 323
            S   +   + E     GLV  HAY+V  LD   FKG  ++ ++L+NPW  + W G +S+
Sbjct: 439 ASTGMMTEAEGE---KWGLVPTHAYAV--LDIREFKG--LRFIQLKNPWSHLRWKGRYSE 491

Query: 324 R-WKDWS-----FVDKDEKARLQHQVTEDGEFWMSYEDFIYHF 360
              K+W+     +++ D +     Q  ++G FW+S++D   ++
Sbjct: 492 NDVKNWTPELQKYLNFDPRTA---QKIDNGIFWISWDDLCQYY 531



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 37/137 (27%), Positives = 53/137 (38%), Gaps = 32/137 (23%)

Query: 388 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 447
           G+W  G SAGGC NF +T   NP Y+  +          E     L+ L           
Sbjct: 694 GKW-SGQSAGGCGNFQETHKNNPIYQFHI----------EKTGPLLIELR---------- 732

Query: 448 GASLFTIGFAIYEVPK-EMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEY 506
           G   +++GF +  V      G    L+K    Y         Y+ +  +      P   +
Sbjct: 733 GPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFC----YLELENI------PSGIF 782

Query: 507 VIVPSTYEPHQEGEFIL 523
            I+PST+ P QEG F L
Sbjct: 783 NIIPSTFLPKQEGPFFL 799


>gi|7019485 programmed cell death 6 [Homo sapiens]
          Length = 191

 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 51/184 (27%), Positives = 93/184 (50%), Gaps = 10/184 (5%)

Query: 545 PVPQPGSSDQESEEQQQFR-NIFKQIAGDDMEICAD-ELKKVLNTVVNKHKDLKTHGFTL 602
           P   PG +   +   Q F  N+F+++  D   + +D EL++ L+             F  
Sbjct: 10  PGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGT-------WTPFNP 62

Query: 603 ESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDA 662
            + RS+I++ D +    +N  EF  +W  I  WQ +F+ YD D SG I+  E++ A++  
Sbjct: 63  VTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGF 122

Query: 663 GFHLNNQLYDIITMRY-ADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLE 721
           G+ L++Q +DI+  ++       I FD FI   + L+ +   F  +D D DG I+++  +
Sbjct: 123 GYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSYEQ 182

Query: 722 WLQL 725
           +L +
Sbjct: 183 YLSM 186


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,895,475
Number of Sequences: 37866
Number of extensions: 1411125
Number of successful extensions: 5127
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 4902
Number of HSP's gapped (non-prelim): 150
length of query: 729
length of database: 18,247,518
effective HSP length: 110
effective length of query: 619
effective length of database: 14,082,258
effective search space: 8716917702
effective search space used: 8716917702
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.