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Search of human proteins with 225703100
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|225703100 calpain 2 isoform 2 [Homo sapiens]
(622 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|225703100 calpain 2 isoform 2 [Homo sapiens] 1278 0.0
gi|157389005 calpain 2 isoform 1 [Homo sapiens] 1276 0.0
gi|12408656 calpain 1, large subunit [Homo sapiens] 853 0.0
gi|221554549 calpain 8 [Homo sapiens] 820 0.0
gi|27765074 calpain 3 isoform c [Homo sapiens] 710 0.0
gi|215490104 calpain 11 [Homo sapiens] 708 0.0
gi|5729758 calpain 9 isoform 1 [Homo sapiens] 689 0.0
gi|47078247 calpain 3 isoform f [Homo sapiens] 675 0.0
gi|27765072 calpain 3 isoform b [Homo sapiens] 675 0.0
gi|4557405 calpain 3 isoform a [Homo sapiens] 673 0.0
gi|7705383 calpain 9 isoform 2 [Homo sapiens] 651 0.0
gi|38707981 calpain 12 [Homo sapiens] 487 e-137
gi|223468608 calpain 14 [Homo sapiens] 426 e-119
gi|37577157 calpain 5 [Homo sapiens] 308 1e-83
gi|41152101 calpain 13 [Homo sapiens] 275 9e-74
gi|13186316 calpain 6 [Homo sapiens] 264 2e-70
gi|27765076 calpain 3 isoform d [Homo sapiens] 234 1e-61
gi|13186302 calpain 10 isoform a [Homo sapiens] 198 1e-50
gi|89353291 calpain 10 isoform c [Homo sapiens] 188 1e-47
gi|4502565 calpain, small subunit 1 [Homo sapiens] 180 3e-45
gi|51599151 calpain, small subunit 1 [Homo sapiens] 180 3e-45
gi|14161692 calpain small subunit 2 [Homo sapiens] 170 4e-42
gi|27765080 calpain 3 isoform e [Homo sapiens] 159 7e-39
gi|27765078 calpain 3 isoform e [Homo sapiens] 159 7e-39
gi|5032105 small optic lobes [Homo sapiens] 138 2e-32
gi|38679884 sorcin isoform b [Homo sapiens] 94 4e-19
gi|4507207 sorcin isoform a [Homo sapiens] 94 4e-19
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap... 92 1e-18
gi|7656959 calpain 7 [Homo sapiens] 86 8e-17
gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens] 75 2e-13
>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
Length = 622
Score = 1278 bits (3308), Expect = 0.0
Identities = 622/622 (100%), Positives = 622/622 (100%)
Query: 1 MEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGI 60
MEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGI
Sbjct: 1 MEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGI 60
Query: 61 FHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGG 120
FHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGG
Sbjct: 61 FHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGG 120
Query: 121 ATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKL 180
ATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKL
Sbjct: 121 ATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKL 180
Query: 181 VKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR 240
VKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR
Sbjct: 181 VKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR 240
Query: 241 HEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYP 300
HEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYP
Sbjct: 241 HEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYP 300
Query: 301 NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE 360
NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE
Sbjct: 301 NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE 360
Query: 361 ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC 420
ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC
Sbjct: 361 ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC 420
Query: 421 IRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR 480
IRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR
Sbjct: 421 IRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR 480
Query: 481 RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR 540
RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR
Sbjct: 481 RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR 540
Query: 541 SGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQ 600
SGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQ
Sbjct: 541 SGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQ 600
Query: 601 LDPENTGTIELDLISWLCFSVL 622
LDPENTGTIELDLISWLCFSVL
Sbjct: 601 LDPENTGTIELDLISWLCFSVL 622
>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
Length = 700
Score = 1276 bits (3303), Expect = 0.0
Identities = 621/621 (100%), Positives = 621/621 (100%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF
Sbjct: 80 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 139
Query: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA
Sbjct: 140 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 199
Query: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181
TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV
Sbjct: 200 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 259
Query: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241
KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH
Sbjct: 260 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 319
Query: 242 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301
EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN
Sbjct: 320 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 379
Query: 302 TFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEE 361
TFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEE
Sbjct: 380 TFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEE 439
Query: 362 LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCI 421
LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCI
Sbjct: 440 LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCI 499
Query: 422 RVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR 481
RVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR
Sbjct: 500 RVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR 559
Query: 482 VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRS 541
VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRS
Sbjct: 560 VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRS 619
Query: 542 GTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQL 601
GTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQL
Sbjct: 620 GTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQL 679
Query: 602 DPENTGTIELDLISWLCFSVL 622
DPENTGTIELDLISWLCFSVL
Sbjct: 680 DPENTGTIELDLISWLCFSVL 700
>gi|12408656 calpain 1, large subunit [Homo sapiens]
Length = 714
Score = 853 bits (2203), Expect = 0.0
Identities = 394/619 (63%), Positives = 504/619 (81%), Gaps = 3/619 (0%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
E+ ++PQFI+ GATRTDICQGALGDCWLLAAIASLTLN+ +L RVVP QSFQ YAGIF
Sbjct: 90 ELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIF 149
Query: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
HFQ WQ+GEWV+VVVDD LP KDG+L+FVHSAEG+EFWSALLEKAYAK+NG YEALSGG+
Sbjct: 150 HFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGS 209
Query: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181
T+EGFEDFTGG+ EWYEL+K P +L++II KAL++GSLLGCSIDI+S D EAITF+KLV
Sbjct: 210 TSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLV 269
Query: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241
KGHAYSVTGA++V G + LIR+RNPWGEVEWTG W+D+ WN +DP ER++L +
Sbjct: 270 KGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKM 329
Query: 242 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301
EDGEFWMSF DF+R ++RLEICNLTPD L S T +KW T +G WRRGSTAGGCRNYP
Sbjct: 330 EDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPA 389
Query: 302 TFWMNPQYLIKLEEEDEDEE--DGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVP 359
TFW+NPQ+ I+L+E D+ ++ D ESGC+F++ L+QKHRRR+R+ G DM TIGF +YEVP
Sbjct: 390 TFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVP 449
Query: 360 EELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDF 419
EL GQ +HL ++FFL N +R RS+ FINLREV RF+LPPGEY++VPSTFEPNK+GDF
Sbjct: 450 PELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDF 509
Query: 420 CIRVFSEKKADYQAVDDEIEANL-EEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTI 478
+R FSEK A +DD+I+ANL +E +SE++ID+ F+ LF QLAGED EIS EL+TI
Sbjct: 510 VLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTI 569
Query: 479 LRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDV 538
L R+++K +D+++ GFS+E+C+ MV+++D DG+GKLGL EF ILW +I+ Y I+R+ D+
Sbjct: 570 LNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDL 629
Query: 539 DRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIF 598
D+SG+M++YEMR A+E AGFK+ +L+++I+ R+++ L +DFDNFV CLVRLET+F+ F
Sbjct: 630 DKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFF 689
Query: 599 KQLDPENTGTIELDLISWL 617
K LD + G + DL WL
Sbjct: 690 KTLDTDLDGVVTFDLFKWL 708
>gi|221554549 calpain 8 [Homo sapiens]
Length = 703
Score = 820 bits (2119), Expect = 0.0
Identities = 386/620 (62%), Positives = 491/620 (79%), Gaps = 3/620 (0%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
E+C PQFI+GGATRTDICQG LGDCWLLAAIASLTLNEE+L RVVP +Q FQENYAGIF
Sbjct: 80 ELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIF 139
Query: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
HFQFWQYGEWVEVV+DDRLPTK+G+LLF+HS +G+EFWSALLEKAYAK+NGCYEAL+GG+
Sbjct: 140 HFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGS 199
Query: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181
T EGFEDFTGGI+E+Y+LKKPP NL++II+KAL GSLLGCSID++SAA++EAIT QKLV
Sbjct: 200 TVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLV 259
Query: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241
K HAYSVTG EEV G +KLIR+RNPWGEVEW+G W+D+ P WN IDP +E L ++
Sbjct: 260 KSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKV 319
Query: 242 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301
EDGEFWMS SDF+R +SRLEICNL+PD+L+S+ KW L +G+W RGSTAGGC+NYP
Sbjct: 320 EDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPA 379
Query: 302 TFWMNPQYLIKLEEEDEDEED--GESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVP 359
T+W NPQ+ I+L+E DED+E+ GE CT L+GL+QK+RR ++++G+ M +IG+ +Y+VP
Sbjct: 380 TYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVP 439
Query: 360 EELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDF 419
+EL T+ HL ++FFL + R+ T++NLREV R +LPPGEY++VPSTFEP KDG+F
Sbjct: 440 KELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEF 499
Query: 420 CIRVFSEKKADYQAVDDEIEANLEEFDISE-DDIDDGFRRLFAQLAGEDAEISAFELQTI 478
C+RVFSEKKA + D + N E SE D DD FRRLF +LAG+D+EI+A L+ +
Sbjct: 500 CLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRLFEKLAGKDSEITANALKIL 559
Query: 479 LRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDV 538
L +KR DIK DGF+I TC+ M+ +LDS+G+G LG EF LW KIQKY +IY E D
Sbjct: 560 LNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDY 619
Query: 539 DRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIF 598
+ SGT++++EMR AL +AGF + Q+ Q I R+A +L I+FD+FV C++RLETLFK+F
Sbjct: 620 NHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLF 679
Query: 599 KQLDPENTGTIELDLISWLC 618
LD + G ++L L WLC
Sbjct: 680 SLLDEDKDGMVQLSLAEWLC 699
>gi|27765074 calpain 3 isoform c [Homo sapiens]
Length = 729
Score = 710 bits (1832), Expect = 0.0
Identities = 331/621 (53%), Positives = 455/621 (73%), Gaps = 6/621 (0%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
EIC +P+FII GA RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIF
Sbjct: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163
Query: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
HFQFW+YGEWV+VV+DD LPT + +L+F S +EFWSALLEKAYAK++G YEAL GG
Sbjct: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223
Query: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181
TTE EDFTGG+AE++E++ P +++KI++KA+++GSL+GCSID E LV
Sbjct: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLV 283
Query: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR- 240
+GHAYSVTG +EV G KL+R+RNPWG+VEW G W+D W+ +D +E+ RL +
Sbjct: 284 RGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQV 343
Query: 241 HEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYP 300
EDGEFWMS+ DF+ H+++LEICNLT D L SD + W ++ +G W RG +AGGCRN+P
Sbjct: 344 TEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFP 403
Query: 301 NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE 360
+TFW NPQY +KL EED+D +D E C+FLV L+QK+RR+ RK+G + TIGF IYEVP+
Sbjct: 404 DTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPK 463
Query: 361 ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC 420
E+ G HL K+FFL N ++ RS T+IN+REV RF+LPP EY++VPST+EP+++G+F
Sbjct: 464 EMHGNKQ-HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFI 522
Query: 421 IRVFSEKKADYQAVDDEIEAN----LEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQ 476
+RVFSEK+ + V++ I + E + FR +F Q+AG+D EI A EL+
Sbjct: 523 LRVFSEKRNLSEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELK 582
Query: 477 TILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREI 536
+L V+ K +D+K+ GF++E+C+ M+ ++D+DGSGKL L+EF+ LW KI+ +QKI++
Sbjct: 583 KVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHY 642
Query: 537 DVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFK 596
D D+SGT+NSYEMR A+ +AGF + QL+ +I R+AD + IDFD+F+ C VRLE +F+
Sbjct: 643 DTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFR 702
Query: 597 IFKQLDPENTGTIELDLISWL 617
F D + G I+L+++ WL
Sbjct: 703 AFHAFDKDGDGIIKLNVLEWL 723
>gi|215490104 calpain 11 [Homo sapiens]
Length = 739
Score = 708 bits (1828), Expect = 0.0
Identities = 331/620 (53%), Positives = 452/620 (72%), Gaps = 4/620 (0%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
+I +P FI+ G + TDICQG LGDCWLLAAI SLT ++L RVVP QSF++NYAGIF
Sbjct: 114 DIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIF 173
Query: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
HFQ WQ+G+WV VVVDDRLPTK+ +L+FVHS E SEFWSALLEKAYAK++G YEALSGG+
Sbjct: 174 HFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGS 233
Query: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181
T EG EDFTGG+A+ ++L++PP NL ++++KA+++ SL+GCSI++TS ++ E++T + LV
Sbjct: 234 TMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLV 293
Query: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241
+GHAYSVTG ++V G ++ LIR+RNPWG +EW G W+D+ W + + + +L +
Sbjct: 294 RGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKT 353
Query: 242 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301
EDGEFWMS+ DFL +++ LEICNLTPDTL+ D W T +G+WRRGS+AGGCRN+P
Sbjct: 354 EDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPG 413
Query: 302 TFWMNPQYLIKLEEEDEDEEDGESG---CTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEV 358
TFW NPQ+ I L E D+ E+D E CT LV L+QK+ R R+ G + TIGF +Y V
Sbjct: 414 TFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAV 473
Query: 359 PEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGD 418
P+E ++HL K FF + S+ F N REV ++ +LPPGEYI++PSTFEP++D D
Sbjct: 474 PKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDAD 533
Query: 419 FCIRVFSEKKADYQAVDD-EIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQT 477
F +RVF+EK ++ +D+ L+E +SEDD+D F LF +AGE EI +ELQ
Sbjct: 534 FLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQR 593
Query: 478 ILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREID 537
+L R+ K + K+ GF ++ C+ M++++D DGSGKLGL EF ILW K++K+ I+RE D
Sbjct: 594 LLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECD 653
Query: 538 VDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKI 597
D SGT+NSYEMR +E+AG K+ ++ QV+VAR+ADD LIIDFD+F+ C +RL+T+F
Sbjct: 654 QDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTF 713
Query: 598 FKQLDPENTGTIELDLISWL 617
F +DP+NTG I L L WL
Sbjct: 714 FLTMDPKNTGHICLSLEQWL 733
>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
Length = 690
Score = 689 bits (1779), Expect = 0.0
Identities = 330/618 (53%), Positives = 454/618 (73%), Gaps = 15/618 (2%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
EI +P+FI+GGATRTDICQG LGDCWLLAAIASLTLN++ LARV+P +QSF YAGIF
Sbjct: 72 EIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIF 131
Query: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
HFQFWQ+ EW++VV+DDRLPT L+F+HSA+ +EFWSALLEKAYAK+NG YEAL GG+
Sbjct: 132 HFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGS 191
Query: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181
E EDFTGG+AE ++ K+ P N ++I++KAL++GSLLGC ID SAA+SEA T L+
Sbjct: 192 AIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLI 251
Query: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241
KGHAYSVTG ++V G +LIRIRNPWG+VEW G W+D+ P W ++ P E++RL
Sbjct: 252 KGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTA 311
Query: 242 -EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYP 300
+DGEFWM+F DF H+ ++EICNLTPD L D KW++T G+W RGSTAGGCRN+
Sbjct: 312 LDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFL 371
Query: 301 NTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE 360
+TFW NPQ + L E+DE +E+ C+FLV L+QK RR+ ++ G ++ TIG+ IYE P+
Sbjct: 372 DTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPD 427
Query: 361 ELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFC 420
+ + HL+K+FF + +R RS TFINLREV +RFKLPPGEYIL+PSTFEP+++ DFC
Sbjct: 428 K-----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFC 482
Query: 421 IRVFSEKKADYQAVDDEIEANLEE-----FDISEDDIDDGFRRLFAQLAGEDAEISAFEL 475
+R+FSEKKA + +D ++ +L E E + + FR LF Q+AGED E++A EL
Sbjct: 483 LRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEEL 542
Query: 476 QTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYRE 535
+ +L VL K++DIK S+ +CK ++ ++D+ G+GKL EF + W K++++ ++
Sbjct: 543 EYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLR 602
Query: 536 IDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLF 595
D D+SGTM++YE+R AL+ AGF++ L Q+IV R+AD++L +DFD+F+ CLVRLE
Sbjct: 603 FDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENAS 662
Query: 596 KIFKQLDPENTGTIELDL 613
++F+ L +N I L++
Sbjct: 663 RVFQALSTKNKEFIHLNI 680
>gi|47078247 calpain 3 isoform f [Homo sapiens]
Length = 728
Score = 675 bits (1742), Expect = 0.0
Identities = 333/707 (47%), Positives = 464/707 (65%), Gaps = 92/707 (13%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
EIC +P+FII GA RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIF
Sbjct: 17 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 76
Query: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
HFQFW+YGEWV+VV+DD LPT + +L+F S +EFWSALLEKAYAK++G YEAL GG
Sbjct: 77 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 136
Query: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI----------------- 164
TTE EDFTGG+AE++E++ P +++KI++KA+++GSL+GCSI
Sbjct: 137 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 196
Query: 165 -----------DITSAADSEA---------------ITFQK-----LVKGHAYSVTGAEE 193
D + DS+ + ++ LV+GHAYSVTG +E
Sbjct: 197 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 256
Query: 194 VESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSD 252
V G KL+R+RNPWG+VEW G W+D W+ +D +E+ RL + EDGEFWMS+ D
Sbjct: 257 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 316
Query: 253 FLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIK 312
F+ H+++LEICNLT D L SD + W ++ +G W RG +AGGCRN+P+TFW NPQY +K
Sbjct: 317 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 376
Query: 313 LEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSK 372
L EED+D +D E C+FLV L+QK+RR+ RK+G + TIGF IYEVP+E+ G HL K
Sbjct: 377 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQK 435
Query: 373 NFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQ 432
+FFL N ++ RS T+IN+REV RF+LPP EY++VPST+EP+++G+F +RVFSEK+ +
Sbjct: 436 DFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSE 495
Query: 433 AVDDEIEANL--------------EEFDI----------------------------SED 450
V++ I + +E + E
Sbjct: 496 EVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQES 555
Query: 451 DIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDG 510
+ FR +F Q+AG+D EI A EL+ +L V+ K +D+K+ GF++E+C+ M+ ++D+DG
Sbjct: 556 EEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDG 615
Query: 511 SGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVA 570
SGKL L+EF+ LW KI+ +QKI++ D D+SGT+NSYEMR A+ +AGF + QL+ +I
Sbjct: 616 SGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITM 675
Query: 571 RFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 617
R+AD + IDFD+F+ C VRLE +F+ F D + G I+L+++ WL
Sbjct: 676 RYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 722
>gi|27765072 calpain 3 isoform b [Homo sapiens]
Length = 815
Score = 675 bits (1742), Expect = 0.0
Identities = 333/707 (47%), Positives = 464/707 (65%), Gaps = 92/707 (13%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
EIC +P+FII GA RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIF
Sbjct: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163
Query: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
HFQFW+YGEWV+VV+DD LPT + +L+F S +EFWSALLEKAYAK++G YEAL GG
Sbjct: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223
Query: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI----------------- 164
TTE EDFTGG+AE++E++ P +++KI++KA+++GSL+GCSI
Sbjct: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 283
Query: 165 -----------DITSAADSEA---------------ITFQK-----LVKGHAYSVTGAEE 193
D + DS+ + ++ LV+GHAYSVTG +E
Sbjct: 284 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 343
Query: 194 VESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSD 252
V G KL+R+RNPWG+VEW G W+D W+ +D +E+ RL + EDGEFWMS+ D
Sbjct: 344 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 403
Query: 253 FLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIK 312
F+ H+++LEICNLT D L SD + W ++ +G W RG +AGGCRN+P+TFW NPQY +K
Sbjct: 404 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463
Query: 313 LEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSK 372
L EED+D +D E C+FLV L+QK+RR+ RK+G + TIGF IYEVP+E+ G HL K
Sbjct: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQK 522
Query: 373 NFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQ 432
+FFL N ++ RS T+IN+REV RF+LPP EY++VPST+EP+++G+F +RVFSEK+ +
Sbjct: 523 DFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSE 582
Query: 433 AVDDEIEANL--------------EEFDI----------------------------SED 450
V++ I + +E + E
Sbjct: 583 EVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQES 642
Query: 451 DIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDG 510
+ FR +F Q+AG+D EI A EL+ +L V+ K +D+K+ GF++E+C+ M+ ++D+DG
Sbjct: 643 EEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDG 702
Query: 511 SGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVA 570
SGKL L+EF+ LW KI+ +QKI++ D D+SGT+NSYEMR A+ +AGF + QL+ +I
Sbjct: 703 SGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITM 762
Query: 571 RFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 617
R+AD + IDFD+F+ C VRLE +F+ F D + G I+L+++ WL
Sbjct: 763 RYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 809
>gi|4557405 calpain 3 isoform a [Homo sapiens]
Length = 821
Score = 673 bits (1736), Expect = 0.0
Identities = 333/713 (46%), Positives = 464/713 (65%), Gaps = 98/713 (13%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
EIC +P+FII GA RTDICQG LGDCW LAAIA LTLN+ +L RV+P +QSF ENYAGIF
Sbjct: 104 EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 163
Query: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
HFQFW+YGEWV+VV+DD LPT + +L+F S +EFWSALLEKAYAK++G YEAL GG
Sbjct: 164 HFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGN 223
Query: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI----------------- 164
TTE EDFTGG+AE++E++ P +++KI++KA+++GSL+GCSI
Sbjct: 224 TTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNM 283
Query: 165 -----------DITSAADSEA---------------ITFQK-----LVKGHAYSVTGAEE 193
D + DS+ + ++ LV+GHAYSVTG +E
Sbjct: 284 GELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDE 343
Query: 194 VESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR-HEDGEFWMSFSD 252
V G KL+R+RNPWG+VEW G W+D W+ +D +E+ RL + EDGEFWMS+ D
Sbjct: 344 VPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 403
Query: 253 FLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIK 312
F+ H+++LEICNLT D L SD + W ++ +G W RG +AGGCRN+P+TFW NPQY +K
Sbjct: 404 FIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLK 463
Query: 313 LEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSK 372
L EED+D +D E C+FLV L+QK+RR+ RK+G + TIGF IYEVP+E+ G HL K
Sbjct: 464 LLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQK 522
Query: 373 NFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQ 432
+FFL N ++ RS T+IN+REV RF+LPP EY++VPST+EP+++G+F +RVFSEK+ +
Sbjct: 523 DFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSE 582
Query: 433 AVDDEIEANL--------------------EEFDI------------------------- 447
V++ I + +E +
Sbjct: 583 EVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPG 642
Query: 448 ---SEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVD 504
E + FR +F Q+AG+D EI A EL+ +L V+ K +D+K+ GF++E+C+ M+
Sbjct: 643 SSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIA 702
Query: 505 MLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQL 564
++D+DGSGKL L+EF+ LW KI+ +QKI++ D D+SGT+NSYEMR A+ +AGF + QL
Sbjct: 703 LMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQL 762
Query: 565 HQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 617
+ +I R+AD + IDFD+F+ C VRLE +F+ F D + G I+L+++ WL
Sbjct: 763 YDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 815
>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
Length = 664
Score = 651 bits (1680), Expect = 0.0
Identities = 319/617 (51%), Positives = 437/617 (70%), Gaps = 39/617 (6%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
EI +P+FI+GGATRTDICQG LGDCWLLAAIASLTLN++ LARV+P +QSF YAGIF
Sbjct: 72 EIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIF 131
Query: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
HFQFWQ+ EW++VV+DDRLPT L+F+HSA+ +EFWSALLEKAYAK+NG YEAL GG+
Sbjct: 132 HFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGS 191
Query: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181
E EDFTGG+AE ++ K+ P N ++I++KAL++GSLLGC ID SAA+SEA T L+
Sbjct: 192 AIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLI 251
Query: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241
KGHAYSVTG ++V G +LIRIRNPWG+VEW G W+D
Sbjct: 252 KGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR------------------- 292
Query: 242 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301
M+F DF H+ ++EICNLTPD L D KW++T G+W RGSTAGGCRN+ +
Sbjct: 293 ------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLD 346
Query: 302 TFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEE 361
TFW NPQ + L E+DE +E+ C+FLV L+QK RR+ ++ G ++ TIG+ IYE P++
Sbjct: 347 TFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK 402
Query: 362 LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCI 421
+ HL+K+FF + +R RS TFINLREV +RFKLPPGEYIL+PSTFEP+++ DFC+
Sbjct: 403 -----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCL 457
Query: 422 RVFSEKKADYQAVDDEIEANLEE-----FDISEDDIDDGFRRLFAQLAGEDAEISAFELQ 476
R+FSEKKA + +D ++ +L E E + + FR LF Q+AGED E++A EL+
Sbjct: 458 RIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELE 517
Query: 477 TILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREI 536
+L VL K++DIK S+ +CK ++ ++D+ G+GKL EF + W K++++ ++
Sbjct: 518 YVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRF 577
Query: 537 DVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFK 596
D D+SGTM++YE+R AL+ AGF++ L Q+IV R+AD++L +DFD+F+ CLVRLE +
Sbjct: 578 DADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASR 637
Query: 597 IFKQLDPENTGTIELDL 613
+F+ L +N I L++
Sbjct: 638 VFQALSTKNKEFIHLNI 654
>gi|38707981 calpain 12 [Homo sapiens]
Length = 719
Score = 487 bits (1254), Expect = e-137
Identities = 266/642 (41%), Positives = 373/642 (58%), Gaps = 34/642 (5%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
E CA+P+FI +RTD+CQG+LG+CW LAA ASLTL +L RVVP Q FQ YAG+F
Sbjct: 80 EFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVF 139
Query: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
HFQ WQ+G W++VVVDDRLP ++G+L+FV S + +EFW+ LLEKAYAK++G YE + GG
Sbjct: 140 HFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGH 199
Query: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAAD-SEAITFQKL 180
E F DFTGG+ E L++ LF ++ AL K SL+G T+ +D E T + L
Sbjct: 200 MNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGA----TALSDRGEYRTEEGL 255
Query: 181 VKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR 240
VKGHAYS+TG +V + +L+R+RNPWG VEWTG W+D+CP W+T+ E R+ L +
Sbjct: 256 VKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVK 315
Query: 241 HEDGEFWMSFSDFLRHYSRLEICNLTPDTL-TSDTYKKWKLTKMDGNWRRGSTAGGCRNY 299
EDGEFWM DFL H+ ++IC+L+P+ L S W + G W RG +GG +
Sbjct: 316 KEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPN 375
Query: 300 PNTFWMNPQYLIKLEEEDEDEEDGESG---------------------CTFLVGLIQKHR 338
TFW NPQ+ + L E DE++++ E G CT L+ LIQ++R
Sbjct: 376 AETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNR 435
Query: 339 RRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFK 398
RR R G T+GF ++++PEEL G + S + L R R+V R
Sbjct: 436 RRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRS-HALLPRLLRADRSPLSARRDVTRRCC 494
Query: 399 LPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRR 458
L PG Y++VPST + DF +RVFSE++ +DD I A+L+ ++ G +
Sbjct: 495 LRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLPLELGLEQ 554
Query: 459 LFAQLAGEDAEISAFELQTILRRVL--AKRQDIKSDGFSIETCKIMVDMLDSDGSGK-LG 515
LF +LAGE+ E++A +LQ +L L A+ + TC+ +L G G+ L
Sbjct: 555 LFQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCE---QLLQCFGHGQSLA 611
Query: 516 LKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADD 575
L F LW + ++Q I+ + D D SGTMNSYE+R AL AGF + QL Q + +R+ D
Sbjct: 612 LHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDS 671
Query: 576 QLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 617
+L +DF+ FV C+ L +F Q G I L W+
Sbjct: 672 RLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWM 713
>gi|223468608 calpain 14 [Homo sapiens]
Length = 684
Score = 426 bits (1095), Expect = e-119
Identities = 231/622 (37%), Positives = 353/622 (56%), Gaps = 17/622 (2%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
E+ ++PQF A R D+CQG +GDCW LAA+ +L L+++IL+RVVPLNQSF E YAGIF
Sbjct: 76 ELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIF 135
Query: 62 HFQFWQYGEWVEVVVDDRLPTKD-GELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGG 120
F FW YG WV VV+DDRLP + G+L+FV S + FW ALLEKAYAK++G YE L G
Sbjct: 136 RFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSG 195
Query: 121 ATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKL 180
+E DFTGG+ L + NL+ I+ +A +L+GC E I L
Sbjct: 196 QVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH-----SGEKILENGL 250
Query: 181 VKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR 240
V+GHAY++TG +V + L+++RNPWG+VEW G W+D+ W + P+E+ L R+
Sbjct: 251 VEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRK 310
Query: 241 HEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRN-Y 299
DGEFWM+ DF H+ L IC LTP L+ + +KW T +G W + STAGG R
Sbjct: 311 DNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLL 370
Query: 300 PNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVP 359
+TFW NPQ+L+ + +E C+ LV L+QK R R RK + + IGF +Y +
Sbjct: 371 QDTFWKNPQFLLSVWRPEEGRRSLRP-CSVLVSLLQKPRHRCRKR-KPLLAIGFYLYRMN 428
Query: 360 EELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDF 419
+ Q L FF N + D F+ +EV L PG Y++VP E ++ +F
Sbjct: 429 KYHDDQR--RLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEF 486
Query: 420 CIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTIL 479
+RVFS K Y+ + +E + + D+ F + F + EI+A +LQ +L
Sbjct: 487 VLRVFSRKHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFE----KHPEINAVQLQNLL 542
Query: 480 RRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVD 539
++ + FS+E C+ ++ +LD + SG + ++EF LW +++ QK++ + D
Sbjct: 543 NQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD-R 601
Query: 540 RSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFK 599
SG +N ++ A+ EAG + + Q+++ R+ +L +DF +F+ ++R+E + +F+
Sbjct: 602 GSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQ 661
Query: 600 QLDPENTGTIELDLISWLCFSV 621
L + G I L W+ ++
Sbjct: 662 NLTQDGKG-IYLQKPEWMMMAL 682
>gi|37577157 calpain 5 [Homo sapiens]
Length = 640
Score = 308 bits (789), Expect = 1e-83
Identities = 169/453 (37%), Positives = 257/453 (56%), Gaps = 48/453 (10%)
Query: 3 ICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVP------LNQSFQEN 56
IC DP+ + G + D+ QG +G+CW +AA +SL E + +V+P +
Sbjct: 57 ICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNA 116
Query: 57 YAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEA 116
YAGIFHF FW++GEWV+VV+DDRLPT + +L++ HS +EFW AL+EKAYAK+ GCY+A
Sbjct: 117 YAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQA 176
Query: 117 LSGGATTEGFEDFTGGIAEWYEL--------KKPPPNLFKIIQKALQKGSLLGCSIDITS 168
L GG T + DFTGG++E +L + LF+ + K +G L+ SI +
Sbjct: 177 LDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVT 236
Query: 169 AADSEAITFQKLVKGHAYSVTGAEEVESNGSL------QKL--IRIRNPWGEVEWTGRWN 220
AAD EA LVKGHAY+VT +V L +KL IR+RNPWGE EW G W+
Sbjct: 237 AADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWS 296
Query: 221 DNCPSWNTIDPEERERL-TRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWK 279
D W + ERE++ +DGEFWM+F D R+++ + C + +T +K W+
Sbjct: 297 DTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVI-NTSHLSIHKTWE 355
Query: 280 LTKMDGNWR-----RGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLI 334
++ G W R + GGC N+ +TF+ NPQY+ ++++ +++ L+ +
Sbjct: 356 EARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDE---------VLICIQ 406
Query: 335 QKHRRRQRKMGEDMH-TIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREV 393
Q+ +R R+ G+ + IGF IY+V E + Q +H ++ + S +IN R V
Sbjct: 407 QRPKRSTRREGKGENLAIGFDIYKVEE--NRQYRMHSLQH-------KAASSIYINSRSV 457
Query: 394 LNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSE 426
R P G Y+++P+TFEP G+F +RVF++
Sbjct: 458 FLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTD 490
>gi|41152101 calpain 13 [Homo sapiens]
Length = 669
Score = 275 bits (703), Expect = 9e-74
Identities = 186/620 (30%), Positives = 296/620 (47%), Gaps = 38/620 (6%)
Query: 7 PQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFW 66
P FI+ +R DI QG DCW LAA+ SLT N + +++ + QSF YAGIF F+FW
Sbjct: 73 PHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFW 131
Query: 67 QYGEWVEVVVDDRLPTKDGELLFVHSA-EGSEFWSALLEKAYAKINGCYEALSGGATTEG 125
Q G+WVEVV+DDRLP + + LFV + EFW LLEKAYAK+ G Y L G +
Sbjct: 132 QCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDA 191
Query: 126 FEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHA 185
D TGG+ L P +L K ++ A + GSL+ C+ + D+ LV HA
Sbjct: 192 LVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATP-SGPTDTAQAMENGLVSLHA 250
Query: 186 YSVTGAEEVESNGSLQKLIRIRNPWG--EVEWTGRWNDNCPSWNTIDPEERERLTRRHED 243
Y+VTGAE+++ +++I + NPWG E EW GRW+D W + +L ++ ED
Sbjct: 251 YTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRED 310
Query: 244 GEFWMSFSDFLRHYSRLEICNLTPDTLT--SDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301
GEFWMS DF + + + IC+ P TL + ++ W G+TAGG RN
Sbjct: 311 GEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN--- 367
Query: 302 TFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEE 361
+ Q+ ++E E C + + K D I G E+
Sbjct: 368 ----DAQFNFSVQEPMEG--TNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFREK 421
Query: 362 LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCI 421
FF + R +S R + L PG Y++V T K +F +
Sbjct: 422 --------FPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLL 471
Query: 422 RVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR 481
R+F + + + ++ + +F + A + +I A +LQ +L +
Sbjct: 472 RIFLKMPDSDRHLSSHFNLRMK----GSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQ 527
Query: 482 VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRS 541
L D FS++ C+ +V +++ +G+L +EF LW ++ YQ +++++
Sbjct: 528 ELLTGP--PGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTS-P 584
Query: 542 GTMNSYEMRKALEEA----GFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKI 597
G + S ++ KA+E G + +L ++ R++D + F + V L+RLE + K
Sbjct: 585 GVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKT 644
Query: 598 FKQLDPENTGTIELDLISWL 617
F+ L + G + L + W+
Sbjct: 645 FRNLSKDGKG-LYLTEMEWM 663
>gi|13186316 calpain 6 [Homo sapiens]
Length = 641
Score = 264 bits (674), Expect = 2e-70
Identities = 163/497 (32%), Positives = 260/497 (52%), Gaps = 55/497 (11%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQ------E 55
+IC DP I+G + + QG LG +++A + L + E + +P ++ + E
Sbjct: 56 DICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTE 115
Query: 56 NYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYE 115
YAGIFHF+FW +GEW EVV+DD LPT +G+L+F S +EFW+ALLEKAYAK+ GCYE
Sbjct: 116 KYAGIFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYE 175
Query: 116 ALSGGATTEGFEDFTGGIAE--------WYELKKPPPNLFKIIQKALQKGSLLGCSIDIT 167
AL G T+ DFTG +AE + EL + LF + K KG L+ CSI+
Sbjct: 176 ALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESP 235
Query: 168 SAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQK--------LIRIRNPWGEVEWTGRW 219
+ + E T L+KGH Y++T ++ L + ++R+RNP G EW+G W
Sbjct: 236 NQEEQEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPW 295
Query: 220 NDNCPSWNTIDPEERERL-TRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKW 278
++ W + +R+ L +DGEFWMS DF R++ +L +C + + + +
Sbjct: 296 SEISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCR----NVNNPIFGRK 351
Query: 279 KLTKMDGNWRRG-----STAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGL 333
+L + G W + +GGC N +TF NPQY+ + E+ G ++ L
Sbjct: 352 ELESVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPED---------GHKVIMSL 402
Query: 334 IQKHRRRQRKMGE-DMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLRE 392
QK R R+MG D + IGF +++V E++ + +H + ++ RA + T+I+ R
Sbjct: 403 QQKDLRTYRRMGRPDNYIIGFELFKV--EMNRKFRLH---HLYIQERA--GTSTYIDTRT 455
Query: 393 VLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDI 452
V L G Y+LVP+ F+ + +F +R+FSE + E L+ +S ++
Sbjct: 456 VFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLR------ELTLDMPKMSCWNL 509
Query: 453 DDGFRRLFAQLAGEDAE 469
G+ ++ Q+ AE
Sbjct: 510 ARGYPKVVTQITVHSAE 526
>gi|27765076 calpain 3 isoform d [Homo sapiens]
Length = 309
Score = 234 bits (598), Expect = 1e-61
Identities = 118/297 (39%), Positives = 181/297 (60%), Gaps = 48/297 (16%)
Query: 369 HLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKK 428
HL K+FFL N ++ RS T+IN+REV RF+LPP EY++VPST+EP+++G+F +RVFSEK+
Sbjct: 7 HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 66
Query: 429 ADYQAVDDEIEANL--------------------EEFDIS-------------------- 448
+ V++ I + +E +
Sbjct: 67 NLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQ 126
Query: 449 --------EDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCK 500
E + FR +F Q+AG+D EI A EL+ +L V+ K +D+K+ GF++E+C+
Sbjct: 127 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCR 186
Query: 501 IMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKM 560
M+ ++D+DGSGKL L+EF+ LW KI+ +QKI++ D D+SGT+NSYEMR A+ +AGF +
Sbjct: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246
Query: 561 PCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 617
QL+ +I R+AD + IDFD+F+ C VRLE +F+ F D + G I+L+++ WL
Sbjct: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 303
>gi|13186302 calpain 10 isoform a [Homo sapiens]
Length = 672
Score = 198 bits (503), Expect = 1e-50
Identities = 142/471 (30%), Positives = 211/471 (44%), Gaps = 60/471 (12%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSF--QENYAG 59
EICA P+ + QG LGDCW L A A+L + +L +V+P Q + Y G
Sbjct: 48 EICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRG 107
Query: 60 IFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSG 119
F + WQ+G WVEV DDRLP G L F FW LLEK YAK++G YE L
Sbjct: 108 SFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWA 167
Query: 120 GATTEGFEDFTGGIAEWYELK----------KPPPNLFKIIQKA--LQKGSLLGCSIDIT 167
G + D TGG+AE + LK +P + ++ L+ L+ C +
Sbjct: 168 GQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSP 227
Query: 168 SAADSEAITFQKLVKGHAYSVTGAEEVESN-GSLQKLIRIRNPWGEVEWTGRWNDNCPSW 226
A E F HA+ V+ E++ G L+RI+NPWG W G W + W
Sbjct: 228 RAGARELGEF------HAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGW 281
Query: 227 NTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEI-CNLTPDTLTSDTYKKWKL---TK 282
+ +D L + ++GEFW+ +FLR + L + +T Y + L
Sbjct: 282 SQVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRA 341
Query: 283 MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHR---- 338
+ G W +G +AGGCRN + F NP++ +++ E E + ++Q+ R
Sbjct: 342 LPGAWVKGQSAGGCRN-NSGFPSNPKFWLRVSEPSE----------VYIAVLQRSRLHAA 390
Query: 339 ---RRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINL----- 390
R R + D HT + +P + +HL K + R +++
Sbjct: 391 DWAGRARALVGDSHT-SWSPASIPGKHYQAVGLHLWK----VEKRRVNLPRVLSMPPVAG 445
Query: 391 -------REVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAV 434
REV R +L PG Y+ VPSTF + G+F +RVFS + A+
Sbjct: 446 TACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGRVSLSAI 496
Score = 50.8 bits (120), Expect = 4e-06
Identities = 43/147 (29%), Positives = 64/147 (43%), Gaps = 17/147 (11%)
Query: 277 KWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQK 336
+W ++ G+WR G TAGG RN+ ++ NP + + E G + L Q
Sbjct: 513 EWGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSVPE-------GPGPRCVRITLHQ- 563
Query: 337 HRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNR 396
R + H IGF I++VPE Q L L + R +EV
Sbjct: 564 ---HCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHR-----YAQEVSRL 615
Query: 397 FKLPPGEYILVPSTFEPNKDGDFCIRV 423
LP G Y +VPST+ P+ +G F + +
Sbjct: 616 CLLPAGTYKVVPSTYLPDTEGAFTVTI 642
>gi|89353291 calpain 10 isoform c [Homo sapiens]
Length = 517
Score = 188 bits (478), Expect = 1e-47
Identities = 138/462 (29%), Positives = 204/462 (44%), Gaps = 62/462 (13%)
Query: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSF--QENYAG 59
EICA P+ + QG LGDCW L A A+L + +L +V+P Q + Y G
Sbjct: 48 EICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRG 107
Query: 60 IFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSG 119
F + WQ+G WVEV DDRLP G L F FW LLEK YAK++G YE L
Sbjct: 108 SFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWA 167
Query: 120 GATTEGFEDFTGGIAEWYELK----------KPPPNLFKIIQKA--LQKGSLLGCSIDIT 167
G + D TGG+AE + LK +P + ++ L+ L+ C +
Sbjct: 168 GQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSP 227
Query: 168 SAADSEAITFQKLVKGHAYSVTGAEEVESN-GSLQKLIRIRNPWGEVEWTGRWNDNCPSW 226
A E F HA+ V+ E++ G L+RI+NPWG W G W + W
Sbjct: 228 RAGARELGEF------HAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGW 281
Query: 227 NTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEI-CNLTPDTLTSDTYKKWKL---TK 282
+ +D L + ++GEFW+ +FLR + L + +T Y + L
Sbjct: 282 SQVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRA 341
Query: 283 MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHR---- 338
+ G W +G +AGGCRN + F NP++ +++ E E + ++Q+ R
Sbjct: 342 LPGAWVKGQSAGGCRN-NSGFPSNPKFWLRVSEPSE----------VYIAVLQRSRLHAA 390
Query: 339 ---RRQRKMGEDMHT--------------IGFGIYEVPEELSGQTNIHLSKNFFLTNRAR 381
R R + D HT +G +++VPE Q L L +
Sbjct: 391 DWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVPEGGRSQDAPPLLLQEPLLSCVP 450
Query: 382 ERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRV 423
R +EV LP G Y +VPST+ P+ +G F + +
Sbjct: 451 HR-----YAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTI 487
>gi|4502565 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 180 bits (457), Expect = 3e-45
Identities = 87/197 (44%), Positives = 128/197 (64%)
Query: 421 IRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR 480
I SE A Y + + +E + FRRLFAQLAG+D E+SA EL IL
Sbjct: 66 ISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILN 125
Query: 481 RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR 540
+V+ + D+K+DGF I+TC+ MV ++DSD +GKLG +EF LW I+++Q IY++ D DR
Sbjct: 126 KVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDR 185
Query: 541 SGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQ 600
SGT+ S E+ A E AGF + L+ +I+ R++D+ +DFDNF+ CLVRL+ +F+ FK
Sbjct: 186 SGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKS 245
Query: 601 LDPENTGTIELDLISWL 617
LD + TG I++++ WL
Sbjct: 246 LDKDGTGQIQVNIQEWL 262
>gi|51599151 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 180 bits (457), Expect = 3e-45
Identities = 87/197 (44%), Positives = 128/197 (64%)
Query: 421 IRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR 480
I SE A Y + + +E + FRRLFAQLAG+D E+SA EL IL
Sbjct: 66 ISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILN 125
Query: 481 RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDR 540
+V+ + D+K+DGF I+TC+ MV ++DSD +GKLG +EF LW I+++Q IY++ D DR
Sbjct: 126 KVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDR 185
Query: 541 SGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQ 600
SGT+ S E+ A E AGF + L+ +I+ R++D+ +DFDNF+ CLVRL+ +F+ FK
Sbjct: 186 SGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKS 245
Query: 601 LDPENTGTIELDLISWL 617
LD + TG I++++ WL
Sbjct: 246 LDKDGTGQIQVNIQEWL 262
>gi|14161692 calpain small subunit 2 [Homo sapiens]
Length = 248
Score = 170 bits (430), Expect = 4e-42
Identities = 80/189 (42%), Positives = 127/189 (67%)
Query: 429 ADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQD 488
A Y + + + SE + FR+ F QLAG D E+ A +L IL +VL+K +D
Sbjct: 54 AQYTPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKD 113
Query: 489 IKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYE 548
+K+DGFS++TC+ +V ++DSD +GKLG +EF LW I+K+Q +Y++ D D SG++ S +
Sbjct: 114 LKTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQ 173
Query: 549 MRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGT 608
+R AL+ AGF++ QL+Q+IV R+A++ +DF+NF+ CLVRL+ +F+ FK LD + G
Sbjct: 174 LRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGL 233
Query: 609 IELDLISWL 617
I++ + WL
Sbjct: 234 IQVSIKEWL 242
>gi|27765080 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 159 bits (402), Expect = 7e-39
Identities = 71/149 (47%), Positives = 109/149 (73%)
Query: 469 EISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQK 528
EI A EL+ +L V+ K +D+K+ GF++E+C+ M+ ++D+DGSGKL L+EF+ LW KI+
Sbjct: 2 EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 61
Query: 529 YQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCL 588
+QKI++ D D+SGT+NSYEMR A+ +AGF + QL+ +I R+AD + IDFD+F+ C
Sbjct: 62 WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 121
Query: 589 VRLETLFKIFKQLDPENTGTIELDLISWL 617
VRLE +F+ F D + G I+L+++ WL
Sbjct: 122 VRLEGMFRAFHAFDKDGDGIIKLNVLEWL 150
>gi|27765078 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 159 bits (402), Expect = 7e-39
Identities = 71/149 (47%), Positives = 109/149 (73%)
Query: 469 EISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQK 528
EI A EL+ +L V+ K +D+K+ GF++E+C+ M+ ++D+DGSGKL L+EF+ LW KI+
Sbjct: 2 EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 61
Query: 529 YQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCL 588
+QKI++ D D+SGT+NSYEMR A+ +AGF + QL+ +I R+AD + IDFD+F+ C
Sbjct: 62 WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 121
Query: 589 VRLETLFKIFKQLDPENTGTIELDLISWL 617
VRLE +F+ F D + G I+L+++ WL
Sbjct: 122 VRLEGMFRAFHAFDKDGDGIIKLNVLEWL 150
>gi|5032105 small optic lobes [Homo sapiens]
Length = 1086
Score = 138 bits (347), Expect = 2e-32
Identities = 82/263 (31%), Positives = 123/263 (46%), Gaps = 20/263 (7%)
Query: 17 TDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVV 76
+DI QG LG+CW L+A+A L +++ RV+ E G + + + G W V+V
Sbjct: 542 SDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQVRLCKDGTWTTVLV 598
Query: 77 DDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEW 136
DD LP + L A+ + W AL+EKA AK++G Y AL G EG TG E
Sbjct: 599 DDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCES 658
Query: 137 YELKKPPPN----------LFKIIQKALQKGSLLGCSI-DITSAADSEAITFQKLVKGHA 185
L+ N ++ + + + G L+G S D A L HA
Sbjct: 659 LALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRHA 718
Query: 186 YSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGE 245
YS+ +V+ +L+R+RNPWG W G W+D P W E + +G
Sbjct: 719 YSILDVRDVQGT----RLLRLRNPWGRFSWNGSWSDEWPHWP--GHLRGELMPHGSSEGV 772
Query: 246 FWMSFSDFLRHYSRLEICNLTPD 268
FWM + DF+R++ ++IC + D
Sbjct: 773 FWMEYGDFVRYFDSVDICKVHSD 795
>gi|38679884 sorcin isoform b [Homo sapiens]
Length = 183
Score = 94.0 bits (232), Expect = 4e-19
Identities = 55/153 (35%), Positives = 85/153 (55%), Gaps = 10/153 (6%)
Query: 460 FAQLAGEDAEISAFELQTILRRVLAKRQDIKSDG---FSIETCKIMVDMLDSDGSGKLGL 516
FA +AG+D +I A ELQ L Q + G F++ETC++MV MLD D SG +G
Sbjct: 24 FAAVAGQDGQIDADELQRCLT------QSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGF 77
Query: 517 KEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQ 576
EF LW + +++ + D DRSGT++ E++KAL GF++ Q I R++ +
Sbjct: 78 NEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNG 137
Query: 577 LIIDFDNFVRCLVRLETLFKIFKQLDPENTGTI 609
I FD+++ C V+L L F++ D G +
Sbjct: 138 K-ITFDDYIACCVKLRALTDSFRRRDTAQQGVV 169
>gi|4507207 sorcin isoform a [Homo sapiens]
Length = 198
Score = 94.0 bits (232), Expect = 4e-19
Identities = 55/153 (35%), Positives = 85/153 (55%), Gaps = 10/153 (6%)
Query: 460 FAQLAGEDAEISAFELQTILRRVLAKRQDIKSDG---FSIETCKIMVDMLDSDGSGKLGL 516
FA +AG+D +I A ELQ L Q + G F++ETC++MV MLD D SG +G
Sbjct: 39 FAAVAGQDGQIDADELQRCLT------QSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGF 92
Query: 517 KEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQ 576
EF LW + +++ + D DRSGT++ E++KAL GF++ Q I R++ +
Sbjct: 93 NEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNG 152
Query: 577 LIIDFDNFVRCLVRLETLFKIFKQLDPENTGTI 609
I FD+++ C V+L L F++ D G +
Sbjct: 153 K-ITFDDYIACCVKLRALTDSFRRRDTAQQGVV 184
>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
sapiens]
Length = 217
Score = 92.4 bits (228), Expect = 1e-18
Identities = 52/155 (33%), Positives = 86/155 (55%), Gaps = 4/155 (2%)
Query: 454 DGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGK 513
D F+ +AG+D E+ A ELQ L + + FS+ETC+IM+ MLD D +GK
Sbjct: 52 DSVYTYFSAVAGQDGEVDAEELQRCLTQ---SGINGTYSPFSLETCRIMIAMLDRDHTGK 108
Query: 514 LGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFA 573
+G F LW + +++ + +D D SGT+ +E+R+A+ G+++ Q IV R++
Sbjct: 109 MGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYS 168
Query: 574 DDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGT 608
+ I FD++V C V+L L F++ D G+
Sbjct: 169 KNGRIF-FDDYVACCVKLRALTDFFRKRDHLQQGS 202
>gi|7656959 calpain 7 [Homo sapiens]
Length = 813
Score = 86.3 bits (212), Expect = 8e-17
Identities = 71/262 (27%), Positives = 123/262 (46%), Gaps = 35/262 (13%)
Query: 19 ICQGALGDCWLLAAIA-----SLTLNEEILARVV-PLNQSFQENY--AGIFHFQFWQYGE 70
I Q + DC +A++A N++++ ++ P N+ + Y G + + G
Sbjct: 282 IKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGV 341
Query: 71 WVEVVVDDRLPTKD-GELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDF 129
+V++DD+LP GELL +S SE W +L+EKAY K+ G Y+ G +
Sbjct: 342 PRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYD-FPGSNSNIDLHAL 400
Query: 130 TGGIAEWYELKK-----PPPNLFKIIQKALQKGS-LLGCSIDITSAADSEAITFQKLVKG 183
TG I E + N F+++ + KG L+ S + + A+ E LV
Sbjct: 401 TGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLITASTGMMTEAEGEK---WGLVPT 457
Query: 184 HAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN-CPSWN-------TIDPEERE 235
HAY+V E + + I+++NPW + W GR+++N +W DP
Sbjct: 458 HAYAVLDIREFKG----LRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDP---- 509
Query: 236 RLTRRHEDGEFWMSFSDFLRHY 257
R ++ ++G FW+S+ D ++Y
Sbjct: 510 RTAQKIDNGIFWISWDDLCQYY 531
Score = 34.3 bits (77), Expect = 0.35
Identities = 36/138 (26%), Positives = 57/138 (41%), Gaps = 31/138 (22%)
Query: 282 KMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQ 341
+++G W G +AGGC N+ T NP Y +E+ L+ L
Sbjct: 691 RINGKWS-GQSAGGCGNFQETHKNNPIYQFHIEKTG----------PLLIEL-------- 731
Query: 342 RKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPP 401
G +++GF + V G H FL + + F L E+ N +P
Sbjct: 732 --RGPRQYSVGFEVVTV--STLGDPGPH----GFLRKSSGDYRCGFCYL-ELEN---IPS 779
Query: 402 GEYILVPSTFEPNKDGDF 419
G + ++PSTF P ++G F
Sbjct: 780 GIFNIIPSTFLPKQEGPF 797
>gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]
Length = 284
Score = 75.1 bits (183), Expect = 2e-13
Identities = 36/120 (30%), Positives = 71/120 (59%), Gaps = 2/120 (1%)
Query: 494 FSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKAL 553
F+ ETC +M++M D SG++ + F LW IQ+++ ++++ D DRSG+++ E+++AL
Sbjct: 151 FNDETCLMMINMFDKTKSGRIDVYGFSALWKFIQQWKNLFQQYDRDRSGSISYTELQQAL 210
Query: 554 EEAGFKMPCQLHQVIVARFADDQL--IIDFDNFVRCLVRLETLFKIFKQLDPENTGTIEL 611
+ G+ + Q Q++V+R+ + D F++ +L+ L + F++ D G I L
Sbjct: 211 SQMGYNLSPQFTQLLVSRYCPRSANPAMQLDRFIQVCTQLQVLTEAFREKDTAVQGNIRL 270
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,521,844
Number of Sequences: 37866
Number of extensions: 1119998
Number of successful extensions: 3969
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 3791
Number of HSP's gapped (non-prelim): 119
length of query: 622
length of database: 18,247,518
effective HSP length: 108
effective length of query: 514
effective length of database: 14,157,990
effective search space: 7277206860
effective search space used: 7277206860
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.