Search of human proteins with 223468608

Search of human proteins with 223468608

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223468608 calpain 14 [Homo sapiens]
         (684 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223468608 calpain 14 [Homo sapiens]                               1415   0.0  
gi|27765074 calpain 3 isoform c [Homo sapiens]                        475   e-134
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                         468   e-131
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       465   e-131
gi|215490104 calpain 11 [Homo sapiens]                                460   e-129
gi|221554549 calpain 8 [Homo sapiens]                                 457   e-128
gi|12408656 calpain 1, large subunit [Homo sapiens]                   448   e-126
gi|27765072 calpain 3 isoform b [Homo sapiens]                        446   e-125
gi|4557405 calpain 3 isoform a [Homo sapiens]                         444   e-124
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                         435   e-122
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       426   e-119
gi|47078247 calpain 3 isoform f [Homo sapiens]                        417   e-116
gi|38707981 calpain 12 [Homo sapiens]                                 383   e-106
gi|41152101 calpain 13 [Homo sapiens]                                 365   e-101
gi|37577157 calpain 5 [Homo sapiens]                                  266   6e-71
gi|13186316 calpain 6 [Homo sapiens]                                  229   5e-60
gi|13186302 calpain 10 isoform a [Homo sapiens]                       184   2e-46
gi|89353291 calpain 10 isoform c [Homo sapiens]                       178   1e-44
gi|5032105 small optic lobes [Homo sapiens]                           156   7e-38
gi|27765076 calpain 3 isoform d [Homo sapiens]                        126   6e-29
gi|7656959 calpain 7 [Homo sapiens]                                    97   5e-20
gi|14161692 calpain small subunit 2 [Homo sapiens]                     95   2e-19
gi|27765080 calpain 3 isoform e [Homo sapiens]                         95   2e-19
gi|27765078 calpain 3 isoform e [Homo sapiens]                         95   2e-19
gi|4502565 calpain, small subunit 1 [Homo sapiens]                     85   2e-16
gi|51599151 calpain, small subunit 1 [Homo sapiens]                    85   2e-16
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap...    55   3e-07
gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]            53   8e-07
gi|13186314 calpain 10 isoform g [Homo sapiens]                        52   2e-06
gi|38679884 sorcin isoform b [Homo sapiens]                            52   2e-06

>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score = 1415 bits (3664), Expect = 0.0
 Identities = 684/684 (100%), Positives = 684/684 (100%)

Query: 1   MSLWPPFRCRWKLAPRYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIGSGS 60
           MSLWPPFRCRWKLAPRYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIGSGS
Sbjct: 1   MSLWPPFRCRWKLAPRYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIGSGS 60

Query: 61  LLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRV 120
           LLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRV
Sbjct: 61  LLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRV 120

Query: 121 VPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEK 180
           VPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEK
Sbjct: 121 VPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEK 180

Query: 181 AYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH 240
           AYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH
Sbjct: 181 AYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH 240

Query: 241 SGEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLS 300
           SGEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLS
Sbjct: 241 SGEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLS 300

Query: 301 PKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKR 360
           PKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKR
Sbjct: 301 PKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKR 360

Query: 361 STAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAI 420
           STAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAI
Sbjct: 361 STAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAI 420

Query: 421 GFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEA 480
           GFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEA
Sbjct: 421 GFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEA 480

Query: 481 HQKSEFVLRVFSRKHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQN 540
           HQKSEFVLRVFSRKHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQN
Sbjct: 481 HQKSEFVLRVFSRKHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQN 540

Query: 541 LLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD 600
           LLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD
Sbjct: 541 LLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD 600

Query: 601 RGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVF 660
           RGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVF
Sbjct: 601 RGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVF 660

Query: 661 QNLTQDGKGIYLQKPEWMMMALYS 684
           QNLTQDGKGIYLQKPEWMMMALYS
Sbjct: 661 QNLTQDGKGIYLQKPEWMMMALYS 684


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score =  475 bits (1222), Expect = e-134
 Identities = 270/677 (39%), Positives = 382/677 (56%), Gaps = 24/677 (3%)

Query: 27  QQDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFA 86
           ++ FE L  +CL    L+ D  FP   +S+      QK P +  WKRPPE+  NP+F   
Sbjct: 58  EKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYS---QKFPIQFVWKRPPEICENPRFIID 114

Query: 87  KAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWV 146
            A R D+CQG +GDCWFLAA+  L L+Q +L RV+P +QSF E YAGIF F FW YG WV
Sbjct: 115 GANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWV 174

Query: 147 PVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTG 206
            VVIDD LP     QLVF  S ++N FW ALLEKAYAKL GSYE L+ G  +EA+ DFTG
Sbjct: 175 DVVIDDCLPTYN-NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233

Query: 207 GVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHS-----GEKILENGLVEGHAYTLTGI 261
           GV     + +A  +++ I+ +A    +L+GC   +      E  +  GLV GHAY++TG+
Sbjct: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGL 293

Query: 262 RKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRK-DNDGEFWMTL 320
            +V  K     LV+LRNPWG+VEW G WSD    W  +   EK  L  +   DGEFWM+ 
Sbjct: 294 DEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSY 353

Query: 321 QDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQF 380
           +DF  HF  L IC LT   L  +  Q WT ++ EGRW +  +AGG R    DTFW NPQ+
Sbjct: 354 EDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRN-FPDTFWTNPQY 412

Query: 381 LLSVWRPEEGRRSLRP-CSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNK-YHDDQRRL 437
            L +   ++        CS LV+L+QK R + RK    L  IGF +Y + K  H +++ L
Sbjct: 413 RLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHL 472

Query: 438 PPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHIF 497
             +FF  N   ++   ++  +EVSQ   L P  Y+IVP   E HQ+ EF+LRVFS K   
Sbjct: 473 QKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNL 532

Query: 498 YE-----IGSNSGVVFSKEIEDQNERQDEF---FTKFFEKHPEINAVQLQNLLNQMTWSS 549
            E     I  +  V      + ++E Q +F   F +      EI A +L+ +LN +    
Sbjct: 533 SEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKH 592

Query: 550 LGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVF-HKQDRGSGYLNW 608
              +   F+LE+C+ ++AL+D + SG +++QEF  LW ++K  QK+F H     SG +N 
Sbjct: 593 KDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINS 652

Query: 609 EQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGK 668
            ++  A+ +AG  L++ +  ++ +RY    + +DF SFI   +R+E M   F    +DG 
Sbjct: 653 YEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGD 712

Query: 669 GIY-LQKPEWMMMALYS 684
           GI  L   EW+ + +Y+
Sbjct: 713 GIIKLNVLEWLQLTMYA 729


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score =  468 bits (1203), Expect = e-131
 Identities = 267/673 (39%), Positives = 393/673 (58%), Gaps = 29/673 (4%)

Query: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFAK 87
           Q FE +  ECL+ G LFED  FPA+ SS+      Q +P    WKRP E+  NP+F    
Sbjct: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQ-IP--FVWKRPGEIVKNPEFILGG 83

Query: 88  AKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVP 147
           A R D+CQG +GDCW LAA+ +L L+Q  L+RV+P +QSF   YAGIF F FW +  W+ 
Sbjct: 84  ATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLD 143

Query: 148 VVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGG 207
           VVIDDRLP     +LVF+ S   N FW ALLEKAYAKL+GSYE L+ G   EA+ DFTGG
Sbjct: 144 VVIDDRLPTFR-DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGG 202

Query: 208 VTMTINLAEAHGNLWDILIEATYNRTLIGC-----QTHSGEKILENGLVEGHAYTLTGIR 262
           V  T    EA  N ++IL +A    +L+GC          E     GL++GHAY++TGI 
Sbjct: 203 VAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGID 262

Query: 263 KVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKE-KILLLRKDNDGEFWMTLQ 321
           +V+ + +   L+++RNPWG+VEW G WSDSS +W  + P E K L     +DGEFWM  +
Sbjct: 263 QVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAFK 322

Query: 322 DFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFL 381
           DFK HF  + IC LTP  L ++A  KW  T+ +G W + STAGG R  L DTFW NPQ  
Sbjct: 323 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFL-DTFWTNPQIK 381

Query: 382 LSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNKYHDDQRRLPPE 440
           LS+   +EG+     CS LV+L+QK R + ++    +L IG+ +Y   +  D    L  +
Sbjct: 382 LSLTEKDEGQEE---CSFLVALMQKDRRKLKRFGANVLTIGYAIY---ECPDKDEHLNKD 435

Query: 441 FFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFS-RKHIFYE 499
           FF+ +   ++   F+  +EVS    L PG Y+++P   E HQ+++F LR+FS +K I  +
Sbjct: 436 FFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRD 495

Query: 500 IGSNSGVVFSKEIE----DQNERQDEFFTKFFE----KHPEINAVQLQNLLNQMTWSSLG 551
           +  N  +   +  +    DQ   +++ F   FE    +  E+ A +L+ +LN +      
Sbjct: 496 MDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKD 555

Query: 552 SRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGYLNWEQ 610
            +    SL +C+ I++L+D + +G +   EF+  W +LK    +F + D   SG ++  +
Sbjct: 556 IKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYE 615

Query: 611 LHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNL-TQDGKG 669
           L  A++ AG  LS  + QL+++RY    LQ+DF  F++ ++R+EN   VFQ L T++ + 
Sbjct: 616 LRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEF 675

Query: 670 IYLQKPEWMMMAL 682
           I+L   E++ + +
Sbjct: 676 IHLNINEFIHLTM 688


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  465 bits (1196), Expect = e-131
 Identities = 254/672 (37%), Positives = 382/672 (56%), Gaps = 19/672 (2%)

Query: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSL--LQKLPPRLQWKRPPELHSNPQFYF 85
           QD+EAL  ECL  G LF+D SFPA  S++G   L         ++WKRP E+ ++PQF  
Sbjct: 30  QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFII 89

Query: 86  AKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNW 145
             A R D+CQG +GDCW LAA+ +L L+++IL+RVVPLNQSF E YAGIF F FW YG W
Sbjct: 90  GGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEW 149

Query: 146 VPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205
           V VV+DDRLP  + G+L+FV S   + FW ALLEKAYAK++G YE L  G  +E   DFT
Sbjct: 150 VEVVVDDRLPTKD-GELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFT 208

Query: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGC-----QTHSGEKILENGLVEGHAYTLTG 260
           GG+     L +   NL+ I+ +A    +L+GC          E I    LV+GHAY++TG
Sbjct: 209 GGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTG 268

Query: 261 IRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTL 320
             +V      + L+++RNPWG+VEW G W+D+   W  + P+E+  L R+  DGEFWM+ 
Sbjct: 269 AEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSF 328

Query: 321 QDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQF 380
            DF  H+  L IC LTP  L+ +  +KW  T  +G W + STAGG R    +TFW NPQ+
Sbjct: 329 SDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRN-YPNTFWMNPQY 387

Query: 381 LLSVWRPEEGRRSLRP-CSVLVSLLQKPRHRCRKR-KPLLAIGFYLYRMNKYHDDQR--R 436
           L+ +   +E        C+ LV L+QK R R RK  + +  IGF +Y + +    Q    
Sbjct: 388 LIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIH 447

Query: 437 LPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHI 496
           L   FF  N    + D F+  +EV     L PG Y++VP   E ++  +F +RVFS K  
Sbjct: 448 LSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKA 507

Query: 497 FYEIGSNSGVVFSKEIEDQNERQDEFFTKFFE----KHPEINAVQLQNLLNQMTWSSLGS 552
            Y+   +      +E +   +  D+ F + F     +  EI+A +LQ +L ++       
Sbjct: 508 DYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDI 567

Query: 553 RQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD-RGSGYLNWEQL 611
           +   FS+E C+ ++ +LD + SG + ++EF  LW +++  QK++ + D   SG +N  ++
Sbjct: 568 KSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEM 627

Query: 612 HAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKG-I 670
             A+ EAG  +   + Q+++ R+   +L +DF +F+  ++R+E +  +F+ L  +  G I
Sbjct: 628 RKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTI 687

Query: 671 YLQKPEWMMMAL 682
            L    W+  ++
Sbjct: 688 ELDLISWLCFSV 699


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  460 bits (1184), Expect = e-129
 Identities = 270/681 (39%), Positives = 384/681 (56%), Gaps = 31/681 (4%)

Query: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSL--LQKLPPRLQWKRPPELHSNPQFYF 85
           Q FE L A CLR G LFED  FPA  SS+G   L    K    + W+RP ++ +NP F  
Sbjct: 64  QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123

Query: 86  AKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNW 145
                 D+CQGI+GDCW LAA+ +L     +L RVVP  QSF + YAGIF F  W +G W
Sbjct: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183

Query: 146 VPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205
           V VV+DDRLP     +LVFV ST ++ FW ALLEKAYAKLSGSYE L  G   E L DFT
Sbjct: 184 VNVVVDDRLPTKN-DKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFT 242

Query: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSG-----EKILENGLVEGHAYTLTG 260
           GGV  +  L     NL  +L +A    +L+GC          E + +  LV GHAY++TG
Sbjct: 243 GGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTG 302

Query: 261 IRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTL 320
           ++ V  + + E L+++RNPWG++EW G WSDS+ +WE ++   ++ LL K  DGEFWM+ 
Sbjct: 303 LQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWMSY 362

Query: 321 QDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQF 380
           QDF  +F LL IC LTP  LS +    W  T  EG W + S+AGG R     TFW NPQF
Sbjct: 363 QDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRN-HPGTFWTNPQF 421

Query: 381 LLSVWR----PEEGRRSLRPCSVLVSLLQKP-RHRCRKRKPLLAIGFYLYRMNKYHDDQR 435
            +S+       ++   ++  C+ LV+L+QK  RH  ++   L  IGF LY + K   + +
Sbjct: 422 KISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQ 481

Query: 436 --RLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSR 493
              L  EFF +       + F   +EVS +L L PG Y+I+P   E H+ ++F+LRVF+ 
Sbjct: 482 DVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTE 541

Query: 494 KHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFE-------KHPEINAVQLQNLLNQMT 546
           KH   E      V ++++++++   +D+    F         +  EI   +LQ LLN+M 
Sbjct: 542 KH--SESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMA 599

Query: 547 WSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGY 605
                 +   F L+AC+ ++ L+D + SG + + EF+ LWK+LK    +F + D+  SG 
Sbjct: 600 IKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGT 659

Query: 606 LNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQ 665
           LN  ++   + +AGI L++ V Q+++ RY    L +DF SFI   LR++ M   F  LT 
Sbjct: 660 LNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFF--LTM 717

Query: 666 DGKG---IYLQKPEWMMMALY 683
           D K    I L   +W+ M ++
Sbjct: 718 DPKNTGHICLSLEQWLQMTMW 738


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  457 bits (1176), Expect = e-128
 Identities = 266/677 (39%), Positives = 382/677 (56%), Gaps = 26/677 (3%)

Query: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPR--LQWKRPPELHSNPQFYF 85
           QDF+ L  +CL +G LF+D  FPA  S++G   L    P    + WKRP EL  +PQF  
Sbjct: 30  QDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFIV 89

Query: 86  AKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNW 145
             A R D+CQG +GDCW LAA+ +L L++++L RVVP +Q F E YAGIF F FW YG W
Sbjct: 90  GGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEW 149

Query: 146 VPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205
           V VVIDDRLP    GQL+F+ S   N FW ALLEKAYAKL+G YE L  G   E   DFT
Sbjct: 150 VEVVIDDRLPTKN-GQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFT 208

Query: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH-----SGEKILENGLVEGHAYTLTG 260
           GG++   +L +   NL+ I+ +A    +L+GC          E I    LV+ HAY++TG
Sbjct: 209 GGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTG 268

Query: 261 IRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTL 320
           + +V  +  PE L++LRNPWG+VEW G WSD + +W  + P+ K  L +K  DGEFWM+L
Sbjct: 269 VEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSL 328

Query: 321 QDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQF 380
            DF   F  L IC L+P  LS E   KW   +  G W + STAGG  Q    T+W NPQF
Sbjct: 329 SDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGG-CQNYPATYWTNPQF 387

Query: 381 LLSVWRPEEGRRSL--RP-CSVLVSLLQKPRHRCRKR--KPLLAIGFYLYRMNK---YHD 432
            + +   +E +      P C+VL+ L+QK R R RKR  + +L+IG+ +Y++ K    H 
Sbjct: 388 KIRLDEVDEDQEESIGEPCCTVLLGLMQKNR-RWRKRIGQGMLSIGYAVYQVPKELESHT 446

Query: 433 DQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFS 492
           D   L  +FF    P ++   ++  +EVS    L PG YL+VP   E  +  EF LRVFS
Sbjct: 447 D-AHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFS 505

Query: 493 RK-----HIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQNLLNQMTW 547
            K      I   +  N       E++ ++++    F K   K  EI A  L+ LLN+   
Sbjct: 506 EKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRLFEKLAGKDSEITANALKILLNEAFS 565

Query: 548 SSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD-RGSGYL 606
                +   F++  C+ +++LLD N +GT+   EF+ LW +++   +++ + D   SG +
Sbjct: 566 KRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTI 625

Query: 607 NWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQD 666
           +  ++  A+R+AG  L+  V Q + +RY   +L ++F SF+  M+R+E +  +F  L +D
Sbjct: 626 DAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDED 685

Query: 667 GKG-IYLQKPEWMMMAL 682
             G + L   EW+   L
Sbjct: 686 KDGMVQLSLAEWLCCVL 702


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  448 bits (1152), Expect = e-126
 Identities = 260/679 (38%), Positives = 384/679 (56%), Gaps = 26/679 (3%)

Query: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPR--LQWKRPPELHSNPQFYF 85
           QD+E L   CL++G LF D +FP    S+G   L         ++WKRP EL SNPQF  
Sbjct: 40  QDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIV 99

Query: 86  AKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNW 145
             A R D+CQG +GDCW LAA+ +L L+  +L RVVP  QSF   YAGIF F  W +G W
Sbjct: 100 DGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEW 159

Query: 146 VPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205
           V VV+DD LP+ + G+LVFV S   N FW ALLEKAYAK++GSYE L  G  SE   DFT
Sbjct: 160 VDVVVDDLLPIKD-GKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFT 218

Query: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSG-----EKILENGLVEGHAYTLTG 260
           GGVT    L +A  +L+ I+++A    +L+GC          E I    LV+GHAY++TG
Sbjct: 219 GGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTG 278

Query: 261 IRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTL 320
            ++V  + +   L+++RNPWG+VEW G WSDSSS+W  + P E+  L  K  DGEFWM+ 
Sbjct: 279 AKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSF 338

Query: 321 QDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQF 380
           +DF   F  L IC LTP  L     +KW  T+ EG W + STAGG R     TFW NPQF
Sbjct: 339 RDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRN-YPATFWVNPQF 397

Query: 381 LLSVWR---PEEGRRSLRPCSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNKYHDDQR- 435
            + +     P++       CS +++L+QK R R R+  + +  IGF +Y +      Q  
Sbjct: 398 KIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPA 457

Query: 436 -RLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRK 494
             L  +FF  N   ++ ++F+  +EVS    L PG Y++VP   E +++ +FVLR FS K
Sbjct: 458 VHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEK 517

Query: 495 -----HIFYEIGSN--SGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQNLLNQMTW 547
                 +  +I +N     V S+E  D+N +    F +   +  EI+  +L+ +LN++  
Sbjct: 518 SAGTVELDDQIQANLPDEQVLSEEEIDENFK--ALFRQLAGEDMEISVKELRTILNRIIS 575

Query: 548 SSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGYL 606
                R   FSLE+C+ ++ L+D + +G + + EF  LW +++    +F K D   SG +
Sbjct: 576 KHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSM 635

Query: 607 NWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQD 666
           +  ++  A+  AG  L+  + +L++ RY  P L +DF +F+  ++R+E M   F+ L  D
Sbjct: 636 SAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTD 695

Query: 667 GKGIY-LQKPEWMMMALYS 684
             G+      +W+ + +++
Sbjct: 696 LDGVVTFDLFKWLQLTMFA 714


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score =  446 bits (1147), Expect = e-125
 Identities = 272/763 (35%), Positives = 388/763 (50%), Gaps = 110/763 (14%)

Query: 27  QQDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFA 86
           ++ FE L  +CL    L+ D  FP   +S+      QK P +  WKRPPE+  NP+F   
Sbjct: 58  EKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYS---QKFPIQFVWKRPPEICENPRFIID 114

Query: 87  KAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWV 146
            A R D+CQG +GDCWFLAA+  L L+Q +L RV+P +QSF E YAGIF F FW YG WV
Sbjct: 115 GANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWV 174

Query: 147 PVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTG 206
            VVIDD LP     QLVF  S ++N FW ALLEKAYAKL GSYE L+ G  +EA+ DFTG
Sbjct: 175 DVVIDDCLPTYN-NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233

Query: 207 GVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSGEKI--------------------- 245
           GV     + +A  +++ I+ +A    +L+GC    G  +                     
Sbjct: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293

Query: 246 LENGL--------------------------------VEGHAYTLTGIRKVTCKHRPEYL 273
           ++N L                                V GHAY++TG+ +V  K     L
Sbjct: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353

Query: 274 VKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRK-DNDGEFWMTLQDFKTHFVLLVI 332
           V+LRNPWG+VEW G WSD    W  +   EK  L  +   DGEFWM+ +DF  HF  L I
Sbjct: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413

Query: 333 CKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEGRR 392
           C LT   L  +  Q WT ++ EGRW +  +AGG R    DTFW NPQ+ L +   ++   
Sbjct: 414 CNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRN-FPDTFWTNPQYRLKLLEEDDDPD 472

Query: 393 SLRP-CSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNK-YHDDQRRLPPEFFQRNTPLS 449
                CS LV+L+QK R + RK    L  IGF +Y + K  H +++ L  +FF  N   +
Sbjct: 473 DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKA 532

Query: 450 QPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHIFYEIGSNS----- 504
           +   ++  +EVSQ   L P  Y+IVP   E HQ+ EF+LRVFS K    E   N+     
Sbjct: 533 RSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDR 592

Query: 505 --GVVF-------SKEI----------------------------EDQNERQDEFFTKFF 527
              ++F       +KE+                             DQ   + + F   F
Sbjct: 593 PVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIF 652

Query: 528 EK----HPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFR 583
           ++      EI A +L+ +LN +       +   F+LE+C+ ++AL+D + SG +++QEF 
Sbjct: 653 KQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFH 712

Query: 584 DLWKQLKLSQKVF-HKQDRGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMD 642
            LW ++K  QK+F H     SG +N  ++  A+ +AG  L++ +  ++ +RY    + +D
Sbjct: 713 HLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNID 772

Query: 643 FVSFIHLMLRVENMEDVFQNLTQDGKGIY-LQKPEWMMMALYS 684
           F SFI   +R+E M   F    +DG GI  L   EW+ + +Y+
Sbjct: 773 FDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 815


>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score =  444 bits (1141), Expect = e-124
 Identities = 272/769 (35%), Positives = 388/769 (50%), Gaps = 116/769 (15%)

Query: 27  QQDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFA 86
           ++ FE L  +CL    L+ D  FP   +S+      QK P +  WKRPPE+  NP+F   
Sbjct: 58  EKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYS---QKFPIQFVWKRPPEICENPRFIID 114

Query: 87  KAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWV 146
            A R D+CQG +GDCWFLAA+  L L+Q +L RV+P +QSF E YAGIF F FW YG WV
Sbjct: 115 GANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWV 174

Query: 147 PVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTG 206
            VVIDD LP     QLVF  S ++N FW ALLEKAYAKL GSYE L+ G  +EA+ DFTG
Sbjct: 175 DVVIDDCLPTYN-NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233

Query: 207 GVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSGEKI--------------------- 245
           GV     + +A  +++ I+ +A    +L+GC    G  +                     
Sbjct: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293

Query: 246 LENGL--------------------------------VEGHAYTLTGIRKVTCKHRPEYL 273
           ++N L                                V GHAY++TG+ +V  K     L
Sbjct: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353

Query: 274 VKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRK-DNDGEFWMTLQDFKTHFVLLVI 332
           V+LRNPWG+VEW G WSD    W  +   EK  L  +   DGEFWM+ +DF  HF  L I
Sbjct: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413

Query: 333 CKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEGRR 392
           C LT   L  +  Q WT ++ EGRW +  +AGG R    DTFW NPQ+ L +   ++   
Sbjct: 414 CNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRN-FPDTFWTNPQYRLKLLEEDDDPD 472

Query: 393 SLRP-CSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNK-YHDDQRRLPPEFFQRNTPLS 449
                CS LV+L+QK R + RK    L  IGF +Y + K  H +++ L  +FF  N   +
Sbjct: 473 DSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKA 532

Query: 450 QPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHIFYEIGSNS----- 504
           +   ++  +EVSQ   L P  Y+IVP   E HQ+ EF+LRVFS K    E   N+     
Sbjct: 533 RSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDR 592

Query: 505 --------GVVF-------SKEI----------------------------EDQNERQDE 521
                    ++F       +KE+                             DQ   + +
Sbjct: 593 PVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQ 652

Query: 522 FFTKFFEK----HPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTM 577
            F   F++      EI A +L+ +LN +       +   F+LE+C+ ++AL+D + SG +
Sbjct: 653 QFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKL 712

Query: 578 SIQEFRDLWKQLKLSQKVF-HKQDRGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGG 636
           ++QEF  LW ++K  QK+F H     SG +N  ++  A+ +AG  L++ +  ++ +RY  
Sbjct: 713 NLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYAD 772

Query: 637 PRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKGIY-LQKPEWMMMALYS 684
             + +DF SFI   +R+E M   F    +DG GI  L   EW+ + +Y+
Sbjct: 773 KHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 821


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score =  435 bits (1118), Expect = e-122
 Identities = 255/672 (37%), Positives = 378/672 (56%), Gaps = 53/672 (7%)

Query: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFAK 87
           Q FE +  ECL+ G LFED  FPA+ SS+      Q +P    WKRP E+  NP+F    
Sbjct: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQ-IP--FVWKRPGEIVKNPEFILGG 83

Query: 88  AKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVP 147
           A R D+CQG +GDCW LAA+ +L L+Q  L+RV+P +QSF   YAGIF F FW +  W+ 
Sbjct: 84  ATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLD 143

Query: 148 VVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGG 207
           VVIDDRLP     +LVF+ S   N FW ALLEKAYAKL+GSYE L+ G   EA+ DFTGG
Sbjct: 144 VVIDDRLPTFR-DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGG 202

Query: 208 VTMTINLAEAHGNLWDILIEATYNRTLIGC-----QTHSGEKILENGLVEGHAYTLTGIR 262
           V  T    EA  N ++IL +A    +L+GC          E     GL++GHAY++TGI 
Sbjct: 203 VAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGID 262

Query: 263 KVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQD 322
           +V+ + +   L+++RNPWG+VEW G WSD                          M  +D
Sbjct: 263 QVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFKD 297

Query: 323 FKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLL 382
           FK HF  + IC LTP  L ++A  KW  T+ +G W + STAGG R  L DTFW NPQ  L
Sbjct: 298 FKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFL-DTFWTNPQIKL 356

Query: 383 SVWRPEEGRRSLRPCSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNKYHDDQRRLPPEF 441
           S+   +EG+     CS LV+L+QK R + ++    +L IG+ +Y   +  D    L  +F
Sbjct: 357 SLTEKDEGQEE---CSFLVALMQKDRRKLKRFGANVLTIGYAIY---ECPDKDEHLNKDF 410

Query: 442 FQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFS-RKHIFYEI 500
           F+ +   ++   F+  +EVS    L PG Y+++P   E HQ+++F LR+FS +K I  ++
Sbjct: 411 FRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDM 470

Query: 501 GSNSGVVFSKEIE----DQNERQDEFFTKFFE----KHPEINAVQLQNLLNQMTWSSLGS 552
             N  +   +  +    DQ   +++ F   FE    +  E+ A +L+ +LN +       
Sbjct: 471 DGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDI 530

Query: 553 RQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGYLNWEQL 611
           +    SL +C+ I++L+D + +G +   EF+  W +LK    +F + D   SG ++  +L
Sbjct: 531 KFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYEL 590

Query: 612 HAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNL-TQDGKGI 670
             A++ AG  LS  + QL+++RY    LQ+DF  F++ ++R+EN   VFQ L T++ + I
Sbjct: 591 RTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFI 650

Query: 671 YLQKPEWMMMAL 682
           +L   E++ + +
Sbjct: 651 HLNINEFIHLTM 662


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  426 bits (1095), Expect = e-119
 Identities = 231/622 (37%), Positives = 353/622 (56%), Gaps = 17/622 (2%)

Query: 76  ELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIF 135
           E+ ++PQF    A R D+CQG +GDCW LAA+ +L L+++IL+RVVPLNQSF E YAGIF
Sbjct: 2   EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61

Query: 136 RFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSG 195
            F FW YG WV VV+DDRLP  + G+L+FV S   + FW ALLEKAYAK++G YE L  G
Sbjct: 62  HFQFWQYGEWVEVVVDDRLPTKD-GELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGG 120

Query: 196 QVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH-----SGEKILENGL 250
             +E   DFTGG+     L +   NL+ I+ +A    +L+GC          E I    L
Sbjct: 121 ATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKL 180

Query: 251 VEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRK 310
           V+GHAY++TG  +V      + L+++RNPWG+VEW G W+D+   W  + P+E+  L R+
Sbjct: 181 VKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRR 240

Query: 311 DNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLL 370
             DGEFWM+  DF  H+  L IC LTP  L+ +  +KW  T  +G W + STAGG R   
Sbjct: 241 HEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRN-Y 299

Query: 371 QDTFWKNPQFLLSVWRPEEGRRSLRP-CSVLVSLLQKPRHRCRKR-KPLLAIGFYLYRMN 428
            +TFW NPQ+L+ +   +E        C+ LV L+QK R R RK  + +  IGF +Y + 
Sbjct: 300 PNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVP 359

Query: 429 KYHDDQR--RLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEF 486
           +    Q    L   FF  N    + D F+  +EV     L PG Y++VP   E ++  +F
Sbjct: 360 EELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDF 419

Query: 487 VLRVFSRKHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFE----KHPEINAVQLQNLL 542
            +RVFS K   Y+   +      +E +   +  D+ F + F     +  EI+A +LQ +L
Sbjct: 420 CIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTIL 479

Query: 543 NQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD-R 601
            ++       +   FS+E C+ ++ +LD + SG + ++EF  LW +++  QK++ + D  
Sbjct: 480 RRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVD 539

Query: 602 GSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQ 661
            SG +N  ++  A+ EAG  +   + Q+++ R+   +L +DF +F+  ++R+E +  +F+
Sbjct: 540 RSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFK 599

Query: 662 NLTQDGKG-IYLQKPEWMMMAL 682
            L  +  G I L    W+  ++
Sbjct: 600 QLDPENTGTIELDLISWLCFSV 621


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score =  417 bits (1073), Expect = e-116
 Identities = 257/714 (35%), Positives = 366/714 (51%), Gaps = 107/714 (14%)

Query: 76  ELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIF 135
           E+  NP+F    A R D+CQG +GDCWFLAA+  L L+Q +L RV+P +QSF E YAGIF
Sbjct: 17  EICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIF 76

Query: 136 RFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSG 195
            F FW YG WV VVIDD LP     QLVF  S ++N FW ALLEKAYAKL GSYE L+ G
Sbjct: 77  HFQFWRYGEWVDVVIDDCLPTYN-NQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGG 135

Query: 196 QVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQT---------------H 240
             +EA+ DFTGGV     + +A  +++ I+ +A    +L+GC                 +
Sbjct: 136 NTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLN 195

Query: 241 SGEKI------LEN--------------------------------GLVEGHAYTLTGIR 262
            GE I      ++N                                GLV GHAY++TG+ 
Sbjct: 196 MGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLD 255

Query: 263 KVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRK-DNDGEFWMTLQ 321
           +V  K     LV+LRNPWG+VEW G WSD    W  +   EK  L  +   DGEFWM+ +
Sbjct: 256 EVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYE 315

Query: 322 DFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFL 381
           DF  HF  L IC LT   L  +  Q WT ++ EGRW +  +AGG R    DTFW NPQ+ 
Sbjct: 316 DFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRN-FPDTFWTNPQYR 374

Query: 382 LSVWRPEEGRRSLRP-CSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNK-YHDDQRRLP 438
           L +   ++        CS LV+L+QK R + RK    L  IGF +Y + K  H +++ L 
Sbjct: 375 LKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQ 434

Query: 439 PEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSRKHIFY 498
            +FF  N   ++   ++  +EVSQ   L P  Y+IVP   E HQ+ EF+LRVFS K    
Sbjct: 435 KDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLS 494

Query: 499 EIGSNS-------GVVF-------SKEI----------------------------EDQN 516
           E   N+        ++F       +KE+                             DQ 
Sbjct: 495 EEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQE 554

Query: 517 ERQDEFFTKFFEK----HPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLN 572
             + + F   F++      EI A +L+ +LN +       +   F+LE+C+ ++AL+D +
Sbjct: 555 SEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTD 614

Query: 573 ASGTMSIQEFRDLWKQLKLSQKVF-HKQDRGSGYLNWEQLHAAMREAGIMLSDDVCQLML 631
            SG +++QEF  LW ++K  QK+F H     SG +N  ++  A+ +AG  L++ +  ++ 
Sbjct: 615 GSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIIT 674

Query: 632 IRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKGIY-LQKPEWMMMALYS 684
           +RY    + +DF SFI   +R+E M   F    +DG GI  L   EW+ + +Y+
Sbjct: 675 MRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 728


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  383 bits (983), Expect = e-106
 Identities = 257/707 (36%), Positives = 367/707 (51%), Gaps = 67/707 (9%)

Query: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLL--QKLPPRLQWKRPPELHSNPQFYF 85
           Q +EA+ A CL +G LF D  FPA   ++G   L    +    ++W RP E  + P+F  
Sbjct: 30  QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFIC 89

Query: 86  AKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNW 145
               R D+CQG +G+CWFLAA  +L L+  +L RVVP  Q F   YAG+F F  W +G W
Sbjct: 90  EDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFGRW 149

Query: 146 VPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205
           + VV+DDRLPV E G+L+FV S  +N FW  LLEKAYAKL GSYE ++ G ++EA VDFT
Sbjct: 150 MDVVVDDRLPVRE-GKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFT 208

Query: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHS--GEKILENGLVEGHAYTLTGIRK 263
           GGV   + L +    L+  L  A    +L+G    S  GE   E GLV+GHAY++TG  K
Sbjct: 209 GGVGEVLYLRQNSMGLFSALRHALAKESLVGATALSDRGEYRTEEGLVKGHAYSITGTHK 268

Query: 264 VTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDF 323
           V        L++LRNPWG VEW G WSDS  +W+ L  + +  LL K  DGEFWM L+DF
Sbjct: 269 VFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVKKEDGEFWMELRDF 328

Query: 324 KTHFVLLVICKLTPGLLS-QEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLL 382
             HF  + IC L+P +L        W     +GRW +   +GG  Q   +TFW NPQF L
Sbjct: 329 LLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGS-QPNAETFWTNPQFRL 387

Query: 383 SVWRPEE-------------GRRSLR---------PCSVLVSLLQKPRHRCR-KRKPLLA 419
           ++  P+E             G    R          C+VL+SL+Q+ R R R K    L 
Sbjct: 388 TLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYLT 447

Query: 420 IGFYLYRMNK----YHDDQRR---LPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYL 472
           +GF+++++ +      D  R    LP       +PLS        ++V++  CL PG YL
Sbjct: 448 VGFHVFQIPEELLGLWDSPRSHALLPRLLRADRSPLS------ARRDVTRRCCLRPGHYL 501

Query: 473 IVPCILEAHQKSEFVLRVFS-RKHIFYEIGSNSGVVFSKEIEDQNERQ-------DEFFT 524
           +VP    A  +++F LRVFS R+H   EI      V S +++             ++ F 
Sbjct: 502 VVPSTAHAGDEADFTLRVFSERRHTAVEIDD----VISADLQSLQGPYLPLELGLEQLFQ 557

Query: 525 KFFEKHPEINAVQLQNLLNQMTWSSLG--SRQPFFSLEACQGILALLDLNASGTMSIQEF 582
           +   +  E+NA QLQ LL+     +    S      L  C+ +L       S  +++  F
Sbjct: 558 ELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQLLQCFGHGQS--LALHHF 615

Query: 583 RDLWKQLKLSQKVFHKQDRG-SGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQM 641
           + LW  L   Q +F+K D   SG +N  +L  A+  AG  L++ + Q +  RY   RL++
Sbjct: 616 QQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRV 675

Query: 642 DFVSFIHLMLRVENMEDVFQNLTQ---DGKG-IYLQKPEWMMMALYS 684
           DF  F+     V ++  +F + +Q    G+G I L   +WM +A +S
Sbjct: 676 DFERFVSC---VAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  365 bits (937), Expect = e-101
 Identities = 245/675 (36%), Positives = 353/675 (52%), Gaps = 42/675 (6%)

Query: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNP-QFYFA 86
           QDF  L   CL  G  F+D +FPA  SSIG   L +K    + WKRP +L   P  F   
Sbjct: 19  QDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILD 78

Query: 87  KAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWV 146
              R D+ QG   DCWFLAAL +L  +     +++ + QSF+ +YAGIFRF FW  G WV
Sbjct: 79  DISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMV-QSFSHQYAGIFRFRFWQCGQWV 137

Query: 147 PVVIDDRLPVNEAGQLVFVSSTYKNL-FWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205
            VVIDDRLPV +  + +FV   ++N  FW  LLEKAYAKL GSY DL  G + +ALVD T
Sbjct: 138 EVVIDDRLPV-QGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLT 196

Query: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSGE----KILENGLVEGHAYTLTGI 261
           GGV   I+L  +  +L   +  AT   +LI C T SG     + +ENGLV  HAYT+TG 
Sbjct: 197 GGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAYTVTGA 256

Query: 262 RKVTCKHRPEYLVKLRNPWG--KVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMT 319
            ++  +   E ++ L NPWG  + EW+G WSD S +WE      K  L +K  DGEFWM+
Sbjct: 257 EQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKREDGEFWMS 316

Query: 320 LQDFKTHFVLLVICKLTPGLL--SQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKN 377
            QDF+  F+ + IC   P  L       + W+  M   +    +TAGG R         +
Sbjct: 317 CQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPR--------ND 368

Query: 378 PQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRH-RCRKRKPLLAIGFYLYRMNKYHDDQRR 436
            QF  SV  P EG   +    V V++   P + +    K  L     L    ++ +   +
Sbjct: 369 AQFNFSVQEPMEGTNVV----VCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFRE---K 421

Query: 437 LPPEFFQ--RNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKS-EFVLRVFSR 493
            PP FF   RNT  S  ++F   +  +    L PG Y++V    +  +KS EF+LR+F +
Sbjct: 422 FPPVFFSSFRNTVQSSNNKF--RRNFTMTYHLSPGNYVVV---AQTRRKSAEFLLRIFLK 476

Query: 494 KHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQNLLNQMTWSSLGSR 553
                   S+   +  K    ++  Q   F ++ ++  +I+A QLQ LLNQ   +  G  
Sbjct: 477 MPDSDRHLSSHFNLRMKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQELLT--GPP 534

Query: 554 QPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRGSGYLNWEQLHA 613
              FSL+ C+ ++AL++L  +G +  +EF  LWK+L   Q VF K     G L    L  
Sbjct: 535 GDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSPGVLLSSDLWK 594

Query: 614 AMREA----GIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKG 669
           A+       GI +S ++  L+ +RY     ++ F S +  ++R+E M   F+NL++DGKG
Sbjct: 595 AIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKG 654

Query: 670 IYLQKPEWMMMALYS 684
           +YL + EWM + +Y+
Sbjct: 655 LYLTEMEWMSLVMYN 669


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  266 bits (679), Expect = 6e-71
 Identities = 172/500 (34%), Positives = 257/500 (51%), Gaps = 56/500 (11%)

Query: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLP-PRLQWKRPPELHSNPQFYFA 86
           Q++ AL  +C R   LFED  FPAT  S+      +  P P ++WKRP  +  +P+ +  
Sbjct: 11  QNYSALRRDCRRRKVLFEDPLFPATDDSL----YYKGTPGPAVRWKRPKGICEDPRLFVD 66

Query: 87  KAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVP------LNQSFTEKYAGIFRFWFW 140
                DL QG VG+CWF+AA  +LA  + +  +V+P       +      YAGIF F FW
Sbjct: 67  GISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFW 126

Query: 141 HYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEA 200
            +G WV VVIDDRLP     QL++  S  +N FW AL+EKAYAKL+G Y+ L  G  ++A
Sbjct: 127 RFGEWVDVVIDDRLPTVN-NQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADA 185

Query: 201 LVDFTGGVTMTINLAEA--------HGNLWDILIEATYNRTLIGCQTHS-----GEKILE 247
           LVDFTGGV+  I+L E            L++ +++      LI     +      E  L 
Sbjct: 186 LVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLA 245

Query: 248 NGLVEGHAYTLTGIRKVTCKH------RPEYL--VKLRNPWGKVEWKGDWSDSSSKWELL 299
            GLV+GHAY +T +RKV   H      + E L  ++LRNPWG+ EW G WSD+S +W+ +
Sbjct: 246 CGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKV 305

Query: 300 SPKEKILL-LRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRW- 357
           S  E+  + +   +DGEFWMT +D   +F  ++ C++          + W      G W 
Sbjct: 306 SKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVI-NTSHLSIHKTWEEARLHGAWT 364

Query: 358 ---EKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRK- 413
              + R   GG     +DTF++NPQ++  V +PE+         VL+ + Q+P+   R+ 
Sbjct: 365 LHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPED--------EVLICIQQRPKRSTRRE 416

Query: 414 -RKPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYL 472
            +   LAIGF +Y++    ++ R+      Q     S    ++  + V        G Y+
Sbjct: 417 GKGENLAIGFDIYKV----EENRQYRMHSLQHKAASS---IYINSRSVFLRTDQPEGRYV 469

Query: 473 IVPCILEAHQKSEFVLRVFS 492
           I+P   E     EF+LRVF+
Sbjct: 470 IIPTTFEPGHTGEFLLRVFT 489


>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score =  229 bits (585), Expect = 5e-60
 Identities = 168/498 (33%), Positives = 255/498 (51%), Gaps = 53/498 (10%)

Query: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFAK 87
           Q ++ L  EC+++  LF D +F     S+    LL   P ++ WKRP ++  +P      
Sbjct: 11  QKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLL---PGKVVWKRPQDICDDPHLIVGN 67

Query: 88  AKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSF------TEKYAGIFRFWFWH 141
                L QG +G    ++A   LA+ +   ++ +P ++        TEKYAGIF F FWH
Sbjct: 68  ISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWH 127

Query: 142 YGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEAL 201
           +G W  VVIDD LP    G LVF  ST  N FW ALLEKAYAKL G YE L    +++ +
Sbjct: 128 FGEWTEVVIDDLLPTIN-GDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDII 186

Query: 202 VDFTGGVTMTIN--------LAEAHGNLWDILIEATYNRTLIGCQTHS---GEKILEN-- 248
           VDFTG +  T++        L E    L+  L +      LI C   S    E+ +E   
Sbjct: 187 VDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDW 246

Query: 249 GLVEGHAYTLTGIRKVTCKHR--------PEYLVKLRNPWGKVEWKGDWSDSSSKWELLS 300
           GL++GH YT+T IRK+    R          Y+V+LRNP G+ EW G WS+ S +W+ L+
Sbjct: 247 GLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLT 306

Query: 301 PKE-KILLLRKDNDGEFWMTLQDFKTHFVLLVICK-LTPGLLSQEAAQK--WTYTMREGR 356
             + K L L   +DGEFWM+L+DF  +F  L +C+ +   +  ++  +     +T+ +  
Sbjct: 307 ASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVDDDP 366

Query: 357 WEKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRK--R 414
              RS   G     +DTF +NPQ++ +V  PE+G +      V++SL QK     R+  R
Sbjct: 367 LMNRS---GGCYNNRDTFLQNPQYIFTV--PEDGHK------VIMSLQQKDLRTYRRMGR 415

Query: 415 KPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIV 474
                IGF L+++    + + RL   + Q     S    ++  + V     L+ G Y++V
Sbjct: 416 PDNYIIGFELFKVEM--NRKFRLHHLYIQERAGTS---TYIDTRTVFLSKYLKKGNYVLV 470

Query: 475 PCILEAHQKSEFVLRVFS 492
           P + +  + SEF+LR+FS
Sbjct: 471 PTMFQHGRTSEFLLRIFS 488


>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score =  184 bits (467), Expect = 2e-46
 Identities = 153/498 (30%), Positives = 229/498 (45%), Gaps = 71/498 (14%)

Query: 43  LFEDTSFPATLSSI--GSGSLLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGD 100
           LF D +FPA  SS+     + L +    + W+RP E+ + P+ +    +   + QG++GD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 101 CWFLAALQALALHQDILSRVVPLNQSF--TEKYAGIFRFWFWHYGNWVPVVIDDRLPVNE 158
           CWFL A  AL   + +L +V+P  Q     ++Y G F    W +G WV V  DDRLP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCL- 131

Query: 159 AGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAH 218
           AG+L F     +++FW  LLEK YAK+ GSYE L +GQV++ALVD TGG+    NL    
Sbjct: 132 AGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVA 191

Query: 219 GN--------LWD----ILIEATYNRTLIGCQTHSGEKILENGLVEGHAYTLTGIRKVTC 266
           G+         W+      +    ++ LI C   S  +     L E HA+ ++ +R++  
Sbjct: 192 GSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLS-PRAGARELGEFHAFIVSDLRELQG 250

Query: 267 K-HRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDFKT 325
           +  +   L++++NPWG+  W+G W +    W  +       LL +  +GEFW+  ++F  
Sbjct: 251 QAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEFLR 310

Query: 326 HFVLLVICKLTPGLLSQEAAQ-KWTYTMR--------EGRWEKRSTAGGQRQLLQDTFWK 376
            F      +LT G    EA   +  YT R         G W K  +AGG R      F  
Sbjct: 311 EF-----DELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN--NSGFPS 363

Query: 377 NPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRC-----RKR----------------- 414
           NP+F L V  P E         V +++LQ+ R        R R                 
Sbjct: 364 NPKFWLRVSEPSE---------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPG 414

Query: 415 KPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIV 474
           K   A+G +L+++ K     RR+         P++       ++EV     L PG YL V
Sbjct: 415 KHYQAVGLHLWKVEK-----RRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAV 469

Query: 475 PCILEAHQKSEFVLRVFS 492
           P         EF+LRVFS
Sbjct: 470 PSTFLKDAPGEFLLRVFS 487



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 56/189 (29%), Positives = 78/189 (41%), Gaps = 23/189 (12%)

Query: 310 KDNDGEFWMTLQDFKTHFVLL-----VICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAG 364
           KD  GEF   L+ F T  V L     V    TPG  +   A +W      G W    TAG
Sbjct: 475 KDAPGEF--LLRVFSTGRVSLSAIRAVAKNTTPG--AALPAGEWGTVQLRGSWRVGQTAG 530

Query: 365 GQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAIGFYL 424
           G R     ++  NP F  SV  PE       P  V ++L Q  R    +  P   IGF++
Sbjct: 531 GSRNFA--SYPTNPCFPFSV--PE----GPGPRCVRITLHQHCRPSDTEFHP---IGFHI 579

Query: 425 YRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKS 484
           +++ +    Q   PP   Q       P R+   +EVS+   L  GTY +VP       + 
Sbjct: 580 FQVPEGGRSQ-DAPPLLLQEPLLSCVPHRY--AQEVSRLCLLPAGTYKVVPSTYLPDTEG 636

Query: 485 EFVLRVFSR 493
            F + + +R
Sbjct: 637 AFTVTIATR 645


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  178 bits (452), Expect = 1e-44
 Identities = 150/499 (30%), Positives = 229/499 (45%), Gaps = 69/499 (13%)

Query: 43  LFEDTSFPATLSSI--GSGSLLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGD 100
           LF D +FPA  SS+     + L +    + W+RP E+ + P+ +    +   + QG++GD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 101 CWFLAALQALALHQDILSRVVPLNQSF--TEKYAGIFRFWFWHYGNWVPVVIDDRLPVNE 158
           CWFL A  AL   + +L +V+P  Q     ++Y G F    W +G WV V  DDRLP   
Sbjct: 73  CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCL- 131

Query: 159 AGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAH 218
           AG+L F     +++FW  LLEK YAK+ GSYE L +GQV++ALVD TGG+    NL    
Sbjct: 132 AGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVA 191

Query: 219 GN--------LWD----ILIEATYNRTLIGCQTHSGEKILENGLVEGHAYTLTGIRKVTC 266
           G+         W+      +    ++ LI C   S  +     L E HA+ ++ +R++  
Sbjct: 192 GSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLS-PRAGARELGEFHAFIVSDLRELQG 250

Query: 267 K-HRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDFKT 325
           +  +   L++++NPWG+  W+G W +    W  +       LL +  +GEFW+  ++F  
Sbjct: 251 QAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEFLR 310

Query: 326 HFVLLVICKLTPGLLSQEAAQ-KWTYTMR--------EGRWEKRSTAGGQRQLLQDTFWK 376
            F      +LT G    EA   +  YT R         G W K  +AGG R      F  
Sbjct: 311 EF-----DELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN--NSGFPS 363

Query: 377 NPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRC-----RKR----------------- 414
           NP+F L V  P E         V +++LQ+ R        R R                 
Sbjct: 364 NPKFWLRVSEPSE---------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPG 414

Query: 415 KPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIV 474
           K   A+G +L+++ +    Q   PP   Q       P R+   +EVS+   L  GTY +V
Sbjct: 415 KHYQAVGLHLWKVPEGGRSQ-DAPPLLLQEPLLSCVPHRY--AQEVSRLCLLPAGTYKVV 471

Query: 475 PCILEAHQKSEFVLRVFSR 493
           P       +  F + + +R
Sbjct: 472 PSTYLPDTEGAFTVTIATR 490


>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score =  156 bits (394), Expect = 7e-38
 Identities = 112/356 (31%), Positives = 167/356 (46%), Gaps = 39/356 (10%)

Query: 6   PFRCRWKLAPRYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIG---SGSLL 62
           P R R  +     R+    + +  +E ++A C  N   F D SFP    S+G     S+ 
Sbjct: 450 PLRRRESMHVEQRRQTDEGEAKALWENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQ 509

Query: 63  QKLPPRLQWKRPPEL-------HSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQD 115
           Q++    QW RP E+       H      F   +  D+ QG++G+CWFL+AL  LA   D
Sbjct: 510 QRVR---QWLRPQEINCSVFRDHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPD 566

Query: 116 ILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWG 175
           ++ RV+       E   G ++      G W  V++DD LP +EAG L+F  +  K L W 
Sbjct: 567 LVERVMVTRSLCAE---GAYQVRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQL-WV 622

Query: 176 ALLEKAYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGN----------LWDIL 225
           AL+EKA AKL GSY  LQ+G+  E L   TG    ++ L  +  N          +W  +
Sbjct: 623 ALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKM 682

Query: 226 IEATYNRTLIGCQTHSGEKILEN------GLVEGHAYTLTGIRKVTCKHRPEYLVKLRNP 279
           + +     L+G     G   +++      GL   HAY++  +R V    +   L++LRNP
Sbjct: 683 LSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRHAYSILDVRDV----QGTRLLRLRNP 738

Query: 280 WGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKL 335
           WG+  W G WSD    W      E  L+    ++G FWM   DF  +F  + ICK+
Sbjct: 739 WGRFSWNGSWSDEWPHWPGHLRGE--LMPHGSSEGVFWMEYGDFVRYFDSVDICKV 792


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score =  126 bits (317), Expect = 6e-29
 Identities = 86/308 (27%), Positives = 145/308 (47%), Gaps = 54/308 (17%)

Query: 431 HDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRV 490
           H +++ L  +FF  N   ++   ++  +EVSQ   L P  Y+IVP   E HQ+ EF+LRV
Sbjct: 2   HGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRV 61

Query: 491 FSRKHIFYEIGSNS-------------GVVF-------SKEI------------------ 512
           FS K    E   N+              ++F       +KE+                  
Sbjct: 62  FSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQ 121

Query: 513 ----------EDQNERQDEFFTKFFEK----HPEINAVQLQNLLNQMTWSSLGSRQPFFS 558
                      DQ   + + F   F++      EI A +L+ +LN +       +   F+
Sbjct: 122 KQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFT 181

Query: 559 LEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGYLNWEQLHAAMRE 617
           LE+C+ ++AL+D + SG +++QEF  LW ++K  QK+F   D   SG +N  ++  A+ +
Sbjct: 182 LESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVND 241

Query: 618 AGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKGIY-LQKPE 676
           AG  L++ +  ++ +RY    + +DF SFI   +R+E M   F    +DG GI  L   E
Sbjct: 242 AGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLE 301

Query: 677 WMMMALYS 684
           W+ + +Y+
Sbjct: 302 WLQLTMYA 309


>gi|7656959 calpain 7 [Homo sapiens]
          Length = 813

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 90/352 (25%), Positives = 157/352 (44%), Gaps = 60/352 (17%)

Query: 70  QWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSR------VVPL 123
           +W RP +L +NP   +  +    + Q IV DC F+A+L   A ++   ++      + P 
Sbjct: 260 KWVRPEDLTNNPTMIYTVSS-FSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQ 318

Query: 124 NQSFTEKYAGIFRFWFWHYGNWVP--VVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKA 181
           N+    +Y    ++    + N VP  V+IDD+LPV+  G+L+   S  K+  W +L+EKA
Sbjct: 319 NKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKA 378

Query: 182 YAKLSGSYE--------DLQ--SGQVSEALVDFTGGVTM----TINLAEAHGNLWDILIE 227
           Y K+ G Y+        DL   +G + E +   +   T     +  +     +  D+LI 
Sbjct: 379 YMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLIT 438

Query: 228 ATYNRTLIGCQTHS-GEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWK 286
           A+      G  T + GEK    GLV  HAY +  IR    + +    ++L+NPW  + WK
Sbjct: 439 AS-----TGMMTEAEGEKW---GLVPTHAYAVLDIR----EFKGLRFIQLKNPWSHLRWK 486

Query: 287 G--------DWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPG 338
           G        +W+    K+    P+      +K ++G FW++  D   ++ ++ +    PG
Sbjct: 487 GRYSENDVKNWTPELQKYLNFDPR----TAQKIDNGIFWISWDDLCQYYDVIYL-SWNPG 541

Query: 339 LLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEG 390
           L  +      T+  ++G  +   +              NPQ+ L V  P+ G
Sbjct: 542 LFKESTCIHSTWDAKQGPVKDAYSLA-----------NNPQYKLEVQCPQGG 582


>gi|14161692 calpain small subunit 2 [Homo sapiens]
          Length = 248

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 52/164 (31%), Positives = 92/164 (56%), Gaps = 2/164 (1%)

Query: 523 FTKFFEKHPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEF 582
           FT+      E+ A  L N+LN++       +   FSL+ C+ I++++D + +G +  +EF
Sbjct: 85  FTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFSLDTCRSIVSVMDSDTTGKLGFEEF 144

Query: 583 RDLWKQLKLSQKVFHKQDRG-SGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQM 641
           + LW  +K  Q V+ + DR  SG L   QL  A++ AG  L++ + Q+++ RY      M
Sbjct: 145 KYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYANEDGDM 204

Query: 642 DFVSFIHLMLRVENMEDVFQNLTQDGKG-IYLQKPEWMMMALYS 684
           DF +FI  ++R++ M   F++L +D  G I +   EW+ + +YS
Sbjct: 205 DFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMYS 248


>gi|27765080 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 51/155 (32%), Positives = 89/155 (57%), Gaps = 2/155 (1%)

Query: 532 EINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKL 591
           EI A +L+ +LN +       +   F+LE+C+ ++AL+D + SG +++QEF  LW ++K 
Sbjct: 2   EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 61

Query: 592 SQKVF-HKQDRGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLM 650
            QK+F H     SG +N  ++  A+ +AG  L++ +  ++ +RY    + +DF SFI   
Sbjct: 62  WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 121

Query: 651 LRVENMEDVFQNLTQDGKGIY-LQKPEWMMMALYS 684
           +R+E M   F    +DG GI  L   EW+ + +Y+
Sbjct: 122 VRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|27765078 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 51/155 (32%), Positives = 89/155 (57%), Gaps = 2/155 (1%)

Query: 532 EINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKL 591
           EI A +L+ +LN +       +   F+LE+C+ ++AL+D + SG +++QEF  LW ++K 
Sbjct: 2   EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 61

Query: 592 SQKVF-HKQDRGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLM 650
            QK+F H     SG +N  ++  A+ +AG  L++ +  ++ +RY    + +DF SFI   
Sbjct: 62  WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 121

Query: 651 LRVENMEDVFQNLTQDGKGIY-LQKPEWMMMALYS 684
           +R+E M   F    +DG GI  L   EW+ + +Y+
Sbjct: 122 VRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|4502565 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 44/155 (28%), Positives = 87/155 (56%), Gaps = 2/155 (1%)

Query: 532 EINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKL 591
           E++A +L N+LN++       +   F ++ C+ ++A++D + +G +  +EF+ LW  +K 
Sbjct: 114 EVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKR 173

Query: 592 SQKVFHKQDRG-SGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLM 650
            Q ++ + D   SG +   +L  A   AG  L++ +  +++ RY      MDF +FI  +
Sbjct: 174 WQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCL 233

Query: 651 LRVENMEDVFQNLTQDGKG-IYLQKPEWMMMALYS 684
           +R++ M   F++L +DG G I +   EW+ + +YS
Sbjct: 234 VRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 268


>gi|51599151 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 44/155 (28%), Positives = 87/155 (56%), Gaps = 2/155 (1%)

Query: 532 EINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKL 591
           E++A +L N+LN++       +   F ++ C+ ++A++D + +G +  +EF+ LW  +K 
Sbjct: 114 EVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKR 173

Query: 592 SQKVFHKQDRG-SGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLM 650
            Q ++ + D   SG +   +L  A   AG  L++ +  +++ RY      MDF +FI  +
Sbjct: 174 WQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCL 233

Query: 651 LRVENMEDVFQNLTQDGKG-IYLQKPEWMMMALYS 684
           +R++ M   F++L +DG G I +   EW+ + +YS
Sbjct: 234 VRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 268


>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
           sapiens]
          Length = 217

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 40/159 (25%), Positives = 74/159 (46%), Gaps = 5/159 (3%)

Query: 504 SGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQ 563
           SG  +S       +    +F+    +  E++A +LQ  L Q   S +      FSLE C+
Sbjct: 39  SGPAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQ---SGINGTYSPFSLETCR 95

Query: 564 GILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDR-GSGYLNWEQLHAAMREAGIML 622
            ++A+LD + +G M    F++LW  L   ++ F   D+ GSG +   +L  A+   G  L
Sbjct: 96  IMIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRL 155

Query: 623 SDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQ 661
           S      ++ RY     ++ F  ++   +++  + D F+
Sbjct: 156 SPQTLTTIVKRY-SKNGRIFFDDYVACCVKLRALTDFFR 193


>gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]
          Length = 284

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 36/134 (26%), Positives = 67/134 (50%), Gaps = 14/134 (10%)

Query: 533 INAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLS 592
           I+  +L+  L    WSS       F+ E C  ++ + D   SG + +  F  LWK ++  
Sbjct: 134 ISMKELKQALVNCNWSS-------FNDETCLMMINMFDKTKSGRIDVYGFSALWKFIQQW 186

Query: 593 QKVFHKQDRG-SGYLNWEQLHAAMREAGIMLSDDVCQLMLIRY----GGPRLQMDFVSFI 647
           + +F + DR  SG +++ +L  A+ + G  LS    QL++ RY      P +Q+D   FI
Sbjct: 187 KNLFQQYDRDRSGSISYTELQQALSQMGYNLSPQFTQLLVSRYCPRSANPAMQLD--RFI 244

Query: 648 HLMLRVENMEDVFQ 661
            +  +++ + + F+
Sbjct: 245 QVCTQLQVLTEAFR 258


>gi|13186314 calpain 10 isoform g [Homo sapiens]
          Length = 139

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 27/80 (33%), Positives = 44/80 (55%), Gaps = 2/80 (2%)

Query: 43  LFEDTSFPATLSSI--GSGSLLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGD 100
           LF D +FPA  SS+     + L +    + W+RP E+ + P+ +    +   + QG++GD
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 101 CWFLAALQALALHQDILSRV 120
           CWFL A  AL   + +L +V
Sbjct: 73  CWFLCACAALQKSRHLLDQV 92


>gi|38679884 sorcin isoform b [Homo sapiens]
          Length = 183

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 39/150 (26%), Positives = 72/150 (48%), Gaps = 5/150 (3%)

Query: 522 FFTKFFEKHPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQE 581
           +F     +  +I+A +LQ  L Q   S +      F+LE C+ ++++LD + SGTM   E
Sbjct: 23  YFAAVAGQDGQIDADELQRCLTQ---SGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNE 79

Query: 582 FRDLWKQLKLSQKVFHKQDRG-SGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQ 640
           F++LW  L   ++ F   D   SG ++ ++L  A+   G  LS      +  RY     +
Sbjct: 80  FKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRY-STNGK 138

Query: 641 MDFVSFIHLMLRVENMEDVFQNLTQDGKGI 670
           + F  +I   +++  + D F+      +G+
Sbjct: 139 ITFDDYIACCVKLRALTDSFRRRDTAQQGV 168


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,754,857
Number of Sequences: 37866
Number of extensions: 1270823
Number of successful extensions: 2929
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 2746
Number of HSP's gapped (non-prelim): 48
length of query: 684
length of database: 18,247,518
effective HSP length: 109
effective length of query: 575
effective length of database: 14,120,124
effective search space: 8119071300
effective search space used: 8119071300
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.