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Search of human proteins with 215490104
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|215490104 calpain 11 [Homo sapiens]
(739 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|215490104 calpain 11 [Homo sapiens] 1527 0.0
gi|12408656 calpain 1, large subunit [Homo sapiens] 822 0.0
gi|157389005 calpain 2 isoform 1 [Homo sapiens] 785 0.0
gi|221554549 calpain 8 [Homo sapiens] 739 0.0
gi|225703100 calpain 2 isoform 2 [Homo sapiens] 708 0.0
gi|27765074 calpain 3 isoform c [Homo sapiens] 703 0.0
gi|27765072 calpain 3 isoform b [Homo sapiens] 674 0.0
gi|4557405 calpain 3 isoform a [Homo sapiens] 671 0.0
gi|5729758 calpain 9 isoform 1 [Homo sapiens] 664 0.0
gi|47078247 calpain 3 isoform f [Homo sapiens] 647 0.0
gi|7705383 calpain 9 isoform 2 [Homo sapiens] 628 e-180
gi|38707981 calpain 12 [Homo sapiens] 528 e-150
gi|223468608 calpain 14 [Homo sapiens] 460 e-129
gi|41152101 calpain 13 [Homo sapiens] 340 3e-93
gi|37577157 calpain 5 [Homo sapiens] 333 3e-91
gi|13186316 calpain 6 [Homo sapiens] 268 1e-71
gi|13186302 calpain 10 isoform a [Homo sapiens] 236 4e-62
gi|89353291 calpain 10 isoform c [Homo sapiens] 231 2e-60
gi|27765076 calpain 3 isoform d [Homo sapiens] 225 1e-58
gi|5032105 small optic lobes [Homo sapiens] 168 1e-41
gi|14161692 calpain small subunit 2 [Homo sapiens] 161 2e-39
gi|27765080 calpain 3 isoform e [Homo sapiens] 159 9e-39
gi|27765078 calpain 3 isoform e [Homo sapiens] 159 9e-39
gi|4502565 calpain, small subunit 1 [Homo sapiens] 156 6e-38
gi|51599151 calpain, small subunit 1 [Homo sapiens] 156 6e-38
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap... 100 6e-21
gi|7656959 calpain 7 [Homo sapiens] 92 1e-18
gi|38679884 sorcin isoform b [Homo sapiens] 91 5e-18
gi|4507207 sorcin isoform a [Homo sapiens] 91 5e-18
gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens] 77 6e-14
>gi|215490104 calpain 11 [Homo sapiens]
Length = 739
Score = 1527 bits (3954), Expect = 0.0
Identities = 739/739 (100%), Positives = 739/739 (100%)
Query: 1 MLYSPGPSLPESAESLDGSQEDKPRGSCAEPTFTDTGMVAHINNSRLKAKGVGQHDNAQN 60
MLYSPGPSLPESAESLDGSQEDKPRGSCAEPTFTDTGMVAHINNSRLKAKGVGQHDNAQN
Sbjct: 1 MLYSPGPSLPESAESLDGSQEDKPRGSCAEPTFTDTGMVAHINNSRLKAKGVGQHDNAQN 60
Query: 61 FGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPL 120
FGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPL
Sbjct: 61 FGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPL 120
Query: 121 FIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQF 180
FIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQF
Sbjct: 121 FIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQF 180
Query: 181 GQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLED 240
GQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLED
Sbjct: 181 GQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLED 240
Query: 241 FTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSV 300
FTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSV
Sbjct: 241 FTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSV 300
Query: 301 TGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWM 360
TGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWM
Sbjct: 301 TGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWM 360
Query: 361 SYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQ 420
SYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQ
Sbjct: 361 SYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQ 420
Query: 421 FKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNI 480
FKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNI
Sbjct: 421 FKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNI 480
Query: 481 QDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFT 540
QDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFT
Sbjct: 481 QDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFT 540
Query: 541 EKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAI 600
EKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAI
Sbjct: 541 EKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAI 600
Query: 601 KFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTL 660
KFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTL
Sbjct: 601 KFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTL 660
Query: 661 NSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPK 720
NSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPK
Sbjct: 661 NSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPK 720
Query: 721 NTGHICLSLEQWLQMTMWG 739
NTGHICLSLEQWLQMTMWG
Sbjct: 721 NTGHICLSLEQWLQMTMWG 739
>gi|12408656 calpain 1, large subunit [Homo sapiens]
Length = 714
Score = 822 bits (2124), Expect = 0.0
Identities = 387/705 (54%), Positives = 520/705 (73%), Gaps = 5/705 (0%)
Query: 36 TGMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFK 95
TG+ A + R + G+G+H+NA + Q +E+LR CL+ G LF D FP P SLG+K
Sbjct: 12 TGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYK 71
Query: 96 DLGPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLL 155
DLGPNS I W+RP ++++NP FI+DG + TDICQG LGDCWLLAAI SLT LL
Sbjct: 72 DLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLL 131
Query: 156 YRVVPRGQSFKKNYAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALL 215
+RVVP GQSF+ YAGIFHFQ+WQFG+WV+VVVDD LP K+ KLVFVHS E +EFWSALL
Sbjct: 132 HRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALL 191
Query: 216 EKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCS 275
EKAYAK++GSYEALSGGST EG EDFTGGV + ++L++ P +L +++ KA+ER SL+GCS
Sbjct: 192 EKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCS 251
Query: 276 IEVTSDSELESMTDKMLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSA 335
I+++S ++E++T K LV+GHAYSVTG + V+YRG++ +LIR+RNPWG +EW GAWSDS+
Sbjct: 252 IDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSS 311
Query: 336 REWEEVASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFY 395
EW V + QL K EDGEFWMS++DF+ FT LEICNLTPD L W+TT Y
Sbjct: 312 SEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLY 371
Query: 396 EGSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPED--DAEGNVVVCTCLVALMQKNW 453
EG+WRRGS+AGGCRN+P TFW NPQFKI L E DDP+D D E C+ ++ALMQK+
Sbjct: 372 EGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESG---CSFVLALMQKHR 428
Query: 454 RHARQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLR 513
R R+ G ++TIGF +Y VP E VHLK++FF SE F N REVS++ R
Sbjct: 429 RRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFR 488
Query: 514 LPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFL 573
LPPGEY+++PSTFEP+++ DF+LR F+EK + + ELD+ A E+ +SE+++D++F
Sbjct: 489 LPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFK 548
Query: 574 HLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLL 633
LF+ +AGE EI V EL+ +LNR+ K K +TKGF L++CR M+NLMD+DG+GKLGL+
Sbjct: 549 ALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLV 608
Query: 634 EFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDL 693
EF ILW +++ ++ IFR+ D D SG++++YEMR+ IE AG KLN K+ ++++ RY++ DL
Sbjct: 609 EFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDL 668
Query: 694 IIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
+DFD+F+ C +RL+TMF FF T+D G + L +WLQ+TM+
Sbjct: 669 AVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMF 713
>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
Length = 700
Score = 785 bits (2027), Expect = 0.0
Identities = 368/697 (52%), Positives = 501/697 (71%), Gaps = 4/697 (0%)
Query: 37 GMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKD 96
G+ A + R A+G+G H+ A + NQ +E LR CL G LF+DP FPA PS+LGFK+
Sbjct: 3 GIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKE 62
Query: 97 LGPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLY 156
LGP S + I W+RP +I +P FI+ G + TDICQG LGDCWLLAAI SLT ++L
Sbjct: 63 LGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILA 122
Query: 157 RVVPRGQSFKKNYAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLE 216
RVVP QSF++NYAGIFHFQ WQ+G+WV VVVDDRLPTK+ +L+FVHS E SEFWSALLE
Sbjct: 123 RVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLE 182
Query: 217 KAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSI 276
KAYAK++G YEALSGG+T EG EDFTGG+A+ ++L++PP NL ++++KA+++ SL+GCSI
Sbjct: 183 KAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSI 242
Query: 277 EVTSDSELESMTDKMLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAR 336
++TS ++ E++T + LV+GHAYSVTG ++V G ++ LIR+RNPWG +EW G W+D+
Sbjct: 243 DITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCP 302
Query: 337 EWEEVASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYE 396
W + + + +L + EDGEFWMS+ DFL +++ LEICNLTPDTL+ D W T +
Sbjct: 303 SWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMD 362
Query: 397 GSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHA 456
G+WRRGS+AGGCRN+P TFW NPQ+ I L E D+ E+D E CT LV L+QK+ R
Sbjct: 363 GNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESG---CTFLVGLIQKHRRRQ 419
Query: 457 RQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPP 516
R+ G + TIGF +Y VP+E ++HL K FF + S+ F N REV ++ +LPP
Sbjct: 420 RKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPP 479
Query: 517 GEYIIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLF 576
GEYI++PSTFEP++D DF +RVF+EK ++ +D+ L+E +SEDD+D F LF
Sbjct: 480 GEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDD-EIEANLEEFDISEDDIDDGFRRLF 538
Query: 577 KIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFK 636
+AGE EI +ELQ +L R+ K + K+ GF ++ C+ M++++D DGSGKLGL EF
Sbjct: 539 AQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFY 598
Query: 637 ILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIID 696
ILW K++K+ I+RE D D SGT+NSYEMR +E+AG K+ ++ QV+VAR+ADD LIID
Sbjct: 599 ILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIID 658
Query: 697 FDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWL 733
FD+F+ C +RL+T+F F +DP+NTG I L L WL
Sbjct: 659 FDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695
>gi|221554549 calpain 8 [Homo sapiens]
Length = 703
Score = 739 bits (1909), Expect = 0.0
Identities = 349/694 (50%), Positives = 486/694 (70%), Gaps = 1/694 (0%)
Query: 40 AHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGP 99
A ++ R +G+G + NA + Q F+ LR CL G LF+DP FPA PS+LG+KDLGP
Sbjct: 6 AGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGP 65
Query: 100 NSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVV 159
S Q I W+RP ++ +P FI+ G + TDICQG LGDCWLLAAI SLT +LLYRVV
Sbjct: 66 GSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVV 125
Query: 160 PRGQSFKKNYAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAY 219
PR Q F++NYAGIFHFQ WQ+G+WV VV+DDRLPTKN +L+F+HS + +EFWSALLEKAY
Sbjct: 126 PRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAY 185
Query: 220 AKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVT 279
AKL+G YEAL+GGST+EG EDFTGG+++ + L++PP NL +++RKA+ SL+GCSI+V+
Sbjct: 186 AKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVS 245
Query: 280 SDSELESMTDKMLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWE 339
S +E E++T + LV+ HAYSVTG+++V+++G E LIR+RNPWG +EW+GAWSD A EW
Sbjct: 246 SAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWN 305
Query: 340 EVASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSW 399
+ + +L K EDGEFWMS DF+ F+ LEICNL+PD+LS + W+ + G W
Sbjct: 306 HIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHW 365
Query: 400 RRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQ 459
RGS+AGGC+N+P T+WTNPQFKI L E D+ ++++ G CT L+ LMQKN R ++
Sbjct: 366 TRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGE-PCCTVLLGLMQKNRRWRKRI 424
Query: 460 GAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEY 519
G + +IG+ +Y VPKE ++ D HL ++FF YQ + + N REVS + RLPPGEY
Sbjct: 425 GQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEY 484
Query: 520 IIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIV 579
+++PSTFEP +D +F LRVF+EK +++ E+ +V + D D F LF+ +
Sbjct: 485 LVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRLFEKL 544
Query: 580 AGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILW 639
AG+ EI L+ LLN K K GF ++ CR MI+L+D +G+G LG +EFK LW
Sbjct: 545 AGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLW 604
Query: 640 KKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDS 699
K++K+++I+ E D +HSGT++++EMR + KAG LN++V Q + RYA L I+FDS
Sbjct: 605 LKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDS 664
Query: 700 FISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWL 733
F++C +RL+T+F F +D G + LSL +WL
Sbjct: 665 FVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698
>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
Length = 622
Score = 708 bits (1828), Expect = 0.0
Identities = 331/620 (53%), Positives = 452/620 (72%), Gaps = 4/620 (0%)
Query: 114 DIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIF 173
+I +P FI+ G + TDICQG LGDCWLLAAI SLT ++L RVVP QSF++NYAGIF
Sbjct: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
Query: 174 HFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGS 233
HFQ WQ+G+WV VVVDDRLPTK+ +L+FVHS E SEFWSALLEKAYAK++G YEALSGG+
Sbjct: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
Query: 234 TMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLV 293
T EG EDFTGG+A+ ++L++PP NL ++++KA+++ SL+GCSI++TS ++ E++T + LV
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181
Query: 294 RGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKT 353
+GHAYSVTG ++V G ++ LIR+RNPWG +EW G W+D+ W + + + +L +
Sbjct: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241
Query: 354 EDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPG 413
EDGEFWMS+ DFL +++ LEICNLTPDTL+ D W T +G+WRRGS+AGGCRN+P
Sbjct: 242 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301
Query: 414 TFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAV 473
TFW NPQ+ I L E D+ E+D E CT LV L+QK+ R R+ G + TIGF +Y V
Sbjct: 302 TFWMNPQYLIKLEEEDEDEEDGESG---CTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEV 358
Query: 474 PKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDAD 533
P+E ++HL K FF + S+ F N REV ++ +LPPGEYI++PSTFEP++D D
Sbjct: 359 PEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGD 418
Query: 534 FLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQR 593
F +RVF+EK ++ +D+ L+E +SEDD+D F LF +AGE EI +ELQ
Sbjct: 419 FCIRVFSEKKADYQAVDD-EIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQT 477
Query: 594 LLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECD 653
+L R+ K + K+ GF ++ C+ M++++D DGSGKLGL EF ILW K++K+ I+RE D
Sbjct: 478 ILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREID 537
Query: 654 QDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTF 713
D SGT+NSYEMR +E+AG K+ ++ QV+VAR+ADD LIIDFD+F+ C +RL+T+F
Sbjct: 538 VDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKI 597
Query: 714 FLTMDPKNTGHICLSLEQWL 733
F +DP+NTG I L L WL
Sbjct: 598 FKQLDPENTGTIELDLISWL 617
>gi|27765074 calpain 3 isoform c [Homo sapiens]
Length = 729
Score = 703 bits (1815), Expect = 0.0
Identities = 351/679 (51%), Positives = 464/679 (68%), Gaps = 13/679 (1%)
Query: 64 QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123
++FE+L CL K L+ DP FP + +SL + P +Q + W+RP +I NP FI+
Sbjct: 59 KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFP----IQFV-WKRPPEICENPRFII 113
Query: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183
DG + TDICQG LGDCW LAAI LT LL+RV+P QSF +NYAGIFHFQ W++G+W
Sbjct: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173
Query: 184 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTG 243
V+VV+DD LPT N++LVF S R+EFWSALLEKAYAKL GSYEAL GG+T E +EDFTG
Sbjct: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
Query: 244 GVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGL 303
GVA+ F+++ P ++ ++++KA+ER SLMGCSI+ + E+ LVRGHAYSVTGL
Sbjct: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGL 293
Query: 304 QDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHK-TEDGEFWMSY 362
+V ++G+ L+R+RNPWG++EWNG+WSD ++W V D + +L H+ TEDGEFWMSY
Sbjct: 294 DEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSY 353
Query: 363 QDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFK 422
+DF+ +FT LEICNLT D L D W + EG W RG SAGGCRN P TFWTNPQ++
Sbjct: 354 EDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYR 413
Query: 423 ISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQD 482
+ L E DD DD+E V+C+ LVALMQKN R R+ GA L TIGF +Y VPKE +
Sbjct: 414 LKLLEEDDDPDDSE---VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ 470
Query: 483 VHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEK 542
HL+K+FF S+ + N REVS + RLPP EY+I+PST+EPH++ +F+LRVF+EK
Sbjct: 471 -HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEK 529
Query: 543 HSESWELDEVNYAEQLQEEKVSED---DMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMA 599
+ S E++ ++ + S D + Q F ++FK +AG+ EI EL+++LN +
Sbjct: 530 RNLSEEVENTISVDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVV 589
Query: 600 IKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGT 659
K K KT GF L++CR MI LMD DGSGKL L EF LW K+K W IF+ D D SGT
Sbjct: 590 NKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGT 649
Query: 660 LNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDP 719
+NSYEMR + AG LNN++ ++ RYAD + IDFDSFI CF+RL+ MF F D
Sbjct: 650 INSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDK 709
Query: 720 KNTGHICLSLEQWLQMTMW 738
G I L++ +WLQ+TM+
Sbjct: 710 DGDGIIKLNVLEWLQLTMY 728
>gi|27765072 calpain 3 isoform b [Homo sapiens]
Length = 815
Score = 674 bits (1738), Expect = 0.0
Identities = 357/765 (46%), Positives = 474/765 (61%), Gaps = 99/765 (12%)
Query: 64 QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123
++FE+L CL K L+ DP FP + +SL + P +Q + W+RP +I NP FI+
Sbjct: 59 KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFP----IQFV-WKRPPEICENPRFII 113
Query: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183
DG + TDICQG LGDCW LAAI LT LL+RV+P QSF +NYAGIFHFQ W++G+W
Sbjct: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173
Query: 184 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTG 243
V+VV+DD LPT N++LVF S R+EFWSALLEKAYAKL GSYEAL GG+T E +EDFTG
Sbjct: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
Query: 244 GVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIE-------------------------- 277
GVA+ F+++ P ++ ++++KA+ER SLMGCSI+
Sbjct: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293
Query: 278 ----VTSDSELESM-TDKM-----------------LVRGHAYSVTGLQDVHYRGKMETL 315
+ DS+L+ +D+ LVRGHAYSVTGL +V ++G+ L
Sbjct: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353
Query: 316 IRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHK-TEDGEFWMSYQDFLNNFTLLEI 374
+R+RNPWG++EWNG+WSD ++W V D + +L H+ TEDGEFWMSY+DF+ +FT LEI
Sbjct: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413
Query: 375 CNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDD 434
CNLT D L D W + EG W RG SAGGCRN P TFWTNPQ+++ L E DD DD
Sbjct: 414 CNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDD 473
Query: 435 AEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQ 494
+E V+C+ LVALMQKN R R+ GA L TIGF +Y VPKE + HL+K+FF
Sbjct: 474 SE---VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNA 529
Query: 495 DHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWEL----- 549
S+ + N REVS + RLPP EY+I+PST+EPH++ +F+LRVF+EK + S E+
Sbjct: 530 SKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTIS 589
Query: 550 -----------DEVNYAEQLQEEKVSED-------------------------DMDQDFL 573
D N ++L ++ SE+ + Q F
Sbjct: 590 VDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFR 649
Query: 574 HLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLL 633
++FK +AG+ EI EL+++LN + K K KT GF L++CR MI LMD DGSGKL L
Sbjct: 650 NIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQ 709
Query: 634 EFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDL 693
EF LW K+K W IF+ D D SGT+NSYEMR + AG LNN++ ++ RYAD +
Sbjct: 710 EFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHM 769
Query: 694 IIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
IDFDSFI CF+RL+ MF F D G I L++ +WLQ+TM+
Sbjct: 770 NIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 814
>gi|4557405 calpain 3 isoform a [Homo sapiens]
Length = 821
Score = 671 bits (1732), Expect = 0.0
Identities = 357/771 (46%), Positives = 474/771 (61%), Gaps = 105/771 (13%)
Query: 64 QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123
++FE+L CL K L+ DP FP + +SL + P +Q + W+RP +I NP FI+
Sbjct: 59 KTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFP----IQFV-WKRPPEICENPRFII 113
Query: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183
DG + TDICQG LGDCW LAAI LT LL+RV+P QSF +NYAGIFHFQ W++G+W
Sbjct: 114 DGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEW 173
Query: 184 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTG 243
V+VV+DD LPT N++LVF S R+EFWSALLEKAYAKL GSYEAL GG+T E +EDFTG
Sbjct: 174 VDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTG 233
Query: 244 GVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIE-------------------------- 277
GVA+ F+++ P ++ ++++KA+ER SLMGCSI+
Sbjct: 234 GVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRN 293
Query: 278 ----VTSDSELESM-TDKM-----------------LVRGHAYSVTGLQDVHYRGKMETL 315
+ DS+L+ +D+ LVRGHAYSVTGL +V ++G+ L
Sbjct: 294 MDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKL 353
Query: 316 IRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHK-TEDGEFWMSYQDFLNNFTLLEI 374
+R+RNPWG++EWNG+WSD ++W V D + +L H+ TEDGEFWMSY+DF+ +FT LEI
Sbjct: 354 VRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI 413
Query: 375 CNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDD 434
CNLT D L D W + EG W RG SAGGCRN P TFWTNPQ+++ L E DD DD
Sbjct: 414 CNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDD 473
Query: 435 AEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQ 494
+E V+C+ LVALMQKN R R+ GA L TIGF +Y VPKE + HL+K+FF
Sbjct: 474 SE---VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNA 529
Query: 495 DHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWEL----- 549
S+ + N REVS + RLPP EY+I+PST+EPH++ +F+LRVF+EK + S E+
Sbjct: 530 SKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTIS 589
Query: 550 -----------------DEVNYAEQLQEEKVSED-------------------------D 567
D N ++L ++ SE+ +
Sbjct: 590 VDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESE 649
Query: 568 MDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGS 627
Q F ++FK +AG+ EI EL+++LN + K K KT GF L++CR MI LMD DGS
Sbjct: 650 EQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGS 709
Query: 628 GKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVAR 687
GKL L EF LW K+K W IF+ D D SGT+NSYEMR + AG LNN++ ++ R
Sbjct: 710 GKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMR 769
Query: 688 YADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
YAD + IDFDSFI CF+RL+ MF F D G I L++ +WLQ+TM+
Sbjct: 770 YADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 820
>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
Length = 690
Score = 664 bits (1713), Expect = 0.0
Identities = 332/679 (48%), Positives = 462/679 (68%), Gaps = 22/679 (3%)
Query: 64 QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123
QSFE++R CL++G LFED FPA SSL + + P V W+RP +I+ NP FI+
Sbjct: 27 QSFEQMRQECLQRGTLFEDADFPASNSSLFYSER-PQIPFV----WKRPGEIVKNPEFIL 81
Query: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183
G + TDICQG LGDCWLLAAI SLT K L RV+P+ QSF YAGIFHFQ WQ +W
Sbjct: 82 GGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEW 141
Query: 184 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTG 243
++VV+DDRLPT D+LVF+HS + +EFWSALLEKAYAKL+GSYEAL GGS +E +EDFTG
Sbjct: 142 LDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
Query: 244 GVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGL 303
GVA++FQ + P+N +L KA++R SL+GC I+ S +E E+ T L++GHAYSVTG+
Sbjct: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGI 261
Query: 304 QDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKT-EDGEFWMSY 362
V +RG+ LIR+RNPWG++EWNG+WSDS+ EW V Q +L H +DGEFWM++
Sbjct: 262 DQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAF 321
Query: 363 QDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFK 422
+DF +F +EICNLTPD L D W T ++GSW RGS+AGGCRN TFWTNPQ K
Sbjct: 322 KDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIK 381
Query: 423 ISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQD 482
+SL E D+ +++ C+ LVALMQK+ R ++ GA + TIG+ +Y P +D
Sbjct: 382 LSLTEKDEGQEE-------CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPD-----KD 429
Query: 483 VHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEK 542
HL K+FF + S+ F N REVS + +LPPGEYI+IPSTFEPH++ADF LR+F+EK
Sbjct: 430 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 489
Query: 543 HSESWELD---EVNYAEQLQEEKV-SEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRM 598
+ + ++D +++ E + E + +Q F LF+ VAGE E+ EL+ +LN +
Sbjct: 490 KAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAV 549
Query: 599 AIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSG 658
K K K K L +C+ +I+LMD G+GKL EFK+ W KLK+W+++F D D SG
Sbjct: 550 LQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSG 609
Query: 659 TLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMD 718
T+++YE+R ++ AG +L++ ++Q++V RYAD++L +DFD F++C +RL+ F +
Sbjct: 610 TMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALS 669
Query: 719 PKNTGHICLSLEQWLQMTM 737
KN I L++ +++ +TM
Sbjct: 670 TKNKEFIHLNINEFIHLTM 688
>gi|47078247 calpain 3 isoform f [Homo sapiens]
Length = 728
Score = 647 bits (1669), Expect = 0.0
Identities = 340/719 (47%), Positives = 448/719 (62%), Gaps = 94/719 (13%)
Query: 110 QRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNY 169
Q+ +I NP FI+DG + TDICQG LGDCW LAAI LT LL+RV+P QSF +NY
Sbjct: 13 QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY 72
Query: 170 AGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEAL 229
AGIFHFQ W++G+WV+VV+DD LPT N++LVF S R+EFWSALLEKAYAKL GSYEAL
Sbjct: 73 AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEAL 132
Query: 230 SGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIE------------ 277
GG+T E +EDFTGGVA+ F+++ P ++ ++++KA+ER SLMGCSI+
Sbjct: 133 KGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPS 192
Query: 278 ------------------VTSDSELESM-TDKM-----------------LVRGHAYSVT 301
+ DS+L+ +D+ LVRGHAYSVT
Sbjct: 193 GLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVT 252
Query: 302 GLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHK-TEDGEFWM 360
GL +V ++G+ L+R+RNPWG++EWNG+WSD ++W V D + +L H+ TEDGEFWM
Sbjct: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312
Query: 361 SYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQ 420
SY+DF+ +FT LEICNLT D L D W + EG W RG SAGGCRN P TFWTNPQ
Sbjct: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQ 372
Query: 421 FKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNI 480
+++ L E DD DD+E V+C+ LVALMQKN R R+ GA L TIGF +Y VPKE
Sbjct: 373 YRLKLLEEDDDPDDSE---VICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGN 429
Query: 481 QDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFT 540
+ HL+K+FF S+ + N REVS + RLPP EY+I+PST+EPH++ +F+LRVF+
Sbjct: 430 KQ-HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFS 488
Query: 541 EKHSESWEL----------------DEVNYAEQLQEEKVSED------------------ 566
EK + S E+ D N ++L ++ SE+
Sbjct: 489 EKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQP 548
Query: 567 -------DMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMI 619
+ Q F ++FK +AG+ EI EL+++LN + K K KT GF L++CR MI
Sbjct: 549 GSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMI 608
Query: 620 NLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNK 679
LMD DGSGKL L EF LW K+K W IF+ D D SGT+NSYEMR + AG LNN+
Sbjct: 609 ALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQ 668
Query: 680 VMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
+ ++ RYAD + IDFDSFI CF+RL+ MF F D G I L++ +WLQ+TM+
Sbjct: 669 LYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 727
>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
Length = 664
Score = 628 bits (1620), Expect = e-180
Identities = 320/678 (47%), Positives = 447/678 (65%), Gaps = 46/678 (6%)
Query: 64 QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123
QSFE++R CL++G LFED FPA SSL + + P V W+RP +I+ NP FI+
Sbjct: 27 QSFEQMRQECLQRGTLFEDADFPASNSSLFYSER-PQIPFV----WKRPGEIVKNPEFIL 81
Query: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183
G + TDICQG LGDCWLLAAI SLT K L RV+P+ QSF YAGIFHFQ WQ +W
Sbjct: 82 GGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEW 141
Query: 184 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTG 243
++VV+DDRLPT D+LVF+HS + +EFWSALLEKAYAKL+GSYEAL GGS +E +EDFTG
Sbjct: 142 LDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
Query: 244 GVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGL 303
GVA++FQ + P+N +L KA++R SL+GC I+ S +E E+ T L++GHAYSVTG+
Sbjct: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGI 261
Query: 304 QDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWMSYQ 363
V +RG+ LIR+RNPWG++EWNG+WSD M+++
Sbjct: 262 DQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFK 296
Query: 364 DFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKI 423
DF +F +EICNLTPD L D W T ++GSW RGS+AGGCRN TFWTNPQ K+
Sbjct: 297 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKL 356
Query: 424 SLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQDV 483
SL E D+ +++ C+ LVALMQK+ R ++ GA + TIG+ +Y P +D
Sbjct: 357 SLTEKDEGQEE-------CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPD-----KDE 404
Query: 484 HLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKH 543
HL K+FF + S+ F N REVS + +LPPGEYI+IPSTFEPH++ADF LR+F+EK
Sbjct: 405 HLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKK 464
Query: 544 SESWELD---EVNYAEQLQEEKV-SEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMA 599
+ + ++D +++ E + E + +Q F LF+ VAGE E+ EL+ +LN +
Sbjct: 465 AITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 524
Query: 600 IKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGT 659
K K K K L +C+ +I+LMD G+GKL EFK+ W KLK+W+++F D D SGT
Sbjct: 525 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 584
Query: 660 LNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDP 719
+++YE+R ++ AG +L++ ++Q++V RYAD++L +DFD F++C +RL+ F +
Sbjct: 585 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 644
Query: 720 KNTGHICLSLEQWLQMTM 737
KN I L++ +++ +TM
Sbjct: 645 KNKEFIHLNINEFIHLTM 662
>gi|38707981 calpain 12 [Homo sapiens]
Length = 719
Score = 528 bits (1361), Expect = e-150
Identities = 289/707 (40%), Positives = 414/707 (58%), Gaps = 31/707 (4%)
Query: 51 GVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQ 110
GVG Q F QS+E +RAACL G LF DP FPA P +LG+ LGP+S+ + + W
Sbjct: 18 GVGA-GRLQLFRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWM 76
Query: 111 RPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYA 170
RP + P FI + +S TD+CQG LG+CW LAA SLT P+LL RVVP GQ F+ YA
Sbjct: 77 RPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYA 136
Query: 171 GIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALS 230
G+FHFQ+WQFG+W++VVVDDRLP + KL+FV S +R+EFW+ LLEKAYAKL GSYE +
Sbjct: 137 GVFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMR 196
Query: 231 GGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDK 290
GG E DFTGGV + L++ L LR A+ + SL+G + SD E T++
Sbjct: 197 GGHMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGAT--ALSDRG-EYRTEE 253
Query: 291 MLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLL 350
LV+GHAYS+TG V L+R+RNPWG +EW GAWSDS W+ + ++ + LL
Sbjct: 254 GLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALL 313
Query: 351 HKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYK-SYWHTTFYEGSWRRGSSAGGCR 409
K EDGEFWM +DFL +F ++IC+L+P+ L + WH ++G W RG ++GG +
Sbjct: 314 VKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQ 373
Query: 410 NHPGTFWTNPQFKISLPEGDDPEDDAE------------------GNVVVCTCLVALMQK 451
+ TFWTNPQF+++L E D+ +D+ E G CT L++L+Q+
Sbjct: 374 PNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQR 433
Query: 452 NWRHARQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQ 511
N R R +G T+GF ++ +P+E + D + S + + R+V+ +
Sbjct: 434 NRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRSHALLPRLLRADRSPL-SARRDVTRR 492
Query: 512 LRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQD 571
L PG Y+++PST +ADF LRVF+E+ + E+D+V A+ LQ + ++
Sbjct: 493 CCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISAD-LQSLQGPYLPLELG 551
Query: 572 FLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKT---KGFGLDACRCMINLMDKDGSG 628
LF+ +AGE +E+ +LQ LL+ +A++ T + GL C ++ S
Sbjct: 552 LEQLFQELAGEEEELNASQLQALLS-IALEPARAHTSTPREIGLRTCEQLLQCFGHGQS- 609
Query: 629 KLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARY 688
L L F+ LW L +W IF + D+D SGT+NSYE+RL + AG LNN++ Q L +RY
Sbjct: 610 -LALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRY 668
Query: 689 ADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQM 735
D L +DF+ F+SC L +F G ICL+ QW+++
Sbjct: 669 RDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEV 715
>gi|223468608 calpain 14 [Homo sapiens]
Length = 684
Score = 460 bits (1184), Expect = e-129
Identities = 270/681 (39%), Positives = 384/681 (56%), Gaps = 31/681 (4%)
Query: 64 QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123
Q FE L A CLR G LFED FPA SS+G L K + W+RP ++ +NP F
Sbjct: 28 QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSL--LQKLPPRLQWKRPPELHSNPQFYF 85
Query: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183
D+CQGI+GDCW LAA+ +L +L RVVP QSF + YAGIF F W +G W
Sbjct: 86 AKAKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNW 145
Query: 184 VNVVVDDRLPTKN-DKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFT 242
V VV+DDRLP +LVFV ST ++ FW ALLEKAYAKLSGSYE L G E L DFT
Sbjct: 146 VPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFT 205
Query: 243 GGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTG 302
GGV + L NL +L +A +L+GC E + + LV GHAY++TG
Sbjct: 206 GGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTHSG-----EKILENGLVEGHAYTLTG 260
Query: 303 LQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWMSY 362
++ V + + E L+++RNPWG++EW G WSDS+ +WE ++ ++ LL K DGEFWM+
Sbjct: 261 IRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTL 320
Query: 363 QDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRN-HPGTFWTNPQF 421
QDF +F LL IC LTP LS + W T EG W + S+AGG R TFW NPQF
Sbjct: 321 QDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQF 380
Query: 422 KISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQ 481
+S+ ++ ++ C+ LV+L+QK RH ++ L IGF LY + K + +
Sbjct: 381 LLSVWR----PEEGRRSLRPCSVLVSLLQKP-RHRCRKRKPLLAIGFYLYRMNKYHDDQR 435
Query: 482 DVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTE 541
L EFF + + F +EVS +L L PG Y+I+P E H+ ++F+LRVF+
Sbjct: 436 --RLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFSR 493
Query: 542 KH--SESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMA 599
KH E V ++++++++ +D+ F + EI +LQ LLN+M
Sbjct: 494 KHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFE-------KHPEINAVQLQNLLNQMT 546
Query: 600 IKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGT 659
+ F L+AC+ ++ L+D + SG + + EF+ LWK+LK +F + D+ SG
Sbjct: 547 WSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGY 605
Query: 660 LNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFF--LTM 717
LN ++ + +AGI L++ V Q+++ RY L +DF SFI LR++ M F LT
Sbjct: 606 LNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQ 665
Query: 718 DPKNTGHICLSLEQWLQMTMW 738
D K I L +W+ M ++
Sbjct: 666 DGKG---IYLQKPEWMMMALY 683
>gi|41152101 calpain 13 [Homo sapiens]
Length = 669
Score = 340 bits (872), Expect = 3e-93
Identities = 238/691 (34%), Positives = 352/691 (50%), Gaps = 51/691 (7%)
Query: 61 FGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPL 120
F +Q F LR CL G F+D FPA SS+G K L K + N+ W+RP+D+ P
Sbjct: 16 FKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLL--QEKRLSNVIWKRPQDLPGGPP 73
Query: 121 -FIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQ 179
FI+D IS DI QG DCW LAA+GSLT P+ +++ QSF YAGIF F+ WQ
Sbjct: 74 HFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL-MVQSFSHQYAGIFRFRFWQ 132
Query: 180 FGQWVNVVVDDRLPTKNDKLVFVHSTERS-EFWSALLEKAYAKLSGSYEALSGGSTMEGL 238
GQWV VV+DDRLP + DK +FV ++ EFW LLEKAYAKL GSY L G + L
Sbjct: 133 CGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDAL 192
Query: 239 EDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAY 298
D TGGV + L P +L++ ++ A + SL+ C+ ++M + LV HAY
Sbjct: 193 VDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAM-ENGLVSLHAY 251
Query: 299 SVTGLQDVHYRGKMETLIRVRNPWG--RIEWNGAWSDSAREWEEVASDIQMQLLHKTEDG 356
+VTG + + YR E +I + NPWG EW G WSD ++EWEE + QL K EDG
Sbjct: 252 TVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKREDG 311
Query: 357 EFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRR----GSSAGGCRNHP 412
EFWMS QDF F + IC+ P TL D+ + H + + +R+ G++AGG RN
Sbjct: 312 EFWMSCQDFQQKFIAMFICSEIPITL--DHGNTLHEGWSQIMFRKQVILGNTAGGPRN-- 367
Query: 413 GTFWTNPQFKISLPEGDDPEDDAEG-NVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLY 471
+ QF S+ ++ EG NVVVC VA+ N + + A+ V+
Sbjct: 368 -----DAQFNFSV------QEPMEGTNVVVCV-TVAVTPSN---LKAEDAKFPLDFQVIL 412
Query: 472 AVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRD 531
A + F+ FF+ +++ S R + L PG Y+++ T +
Sbjct: 413 AGSQRFRE----KFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKS 466
Query: 532 ADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYEL 591
A+FLLR+F + L ++ + SE Q +F A + +I +L
Sbjct: 467 AEFLLRIFLKMPDSDRHLS--SHFNLRMKGSPSEHGSQQS---IFNRYAQQRLDIDATQL 521
Query: 592 QRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRE 651
Q LLN+ + F LD CR ++ LM+ +G+L EF LWK+L + +F++
Sbjct: 522 QGLLNQELLTGPPGDM--FSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQK 579
Query: 652 CDQDHSGTLNSYEMRLVIEKA----GIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRL 707
Q G L S ++ IE GI ++ +++ ++ RY+D + F S + +RL
Sbjct: 580 V-QTSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRL 638
Query: 708 KTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
+ M F + G + L+ +W+ + M+
Sbjct: 639 EAMAKTFRNLSKDGKG-LYLTEMEWMSLVMY 668
>gi|37577157 calpain 5 [Homo sapiens]
Length = 640
Score = 333 bits (854), Expect = 3e-91
Identities = 199/519 (38%), Positives = 290/519 (55%), Gaps = 58/519 (11%)
Query: 61 FGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDL-GPNSKNVQNISWQRPKDIINNP 119
+ +Q++ LR C R+ LFEDPLFPA SL +K GP + W+RPK I +P
Sbjct: 8 YEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA------VRWKRPKGICEDP 61
Query: 120 LFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVP--RGQSF---KKN-YAGIF 173
+DGIS D+ QG +G+CW +AA SL + L +V+P + Q + K N YAGIF
Sbjct: 62 RLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIF 121
Query: 174 HFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGS 233
HF W+FG+WV+VV+DDRLPT N++L++ HS R+EFW AL+EKAYAKL+G Y+AL GG+
Sbjct: 122 HFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGN 181
Query: 234 TMEGLEDFTGGVAQSFQL--------QRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELE 285
T + L DFTGGV++ L + L + K R L+ SI+ + +++E
Sbjct: 182 TADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADME 241
Query: 286 SMTDKMLVRGHAYSVTGLQDVH--------YRGKMETLIRVRNPWGRIEWNGAWSDSARE 337
+ LV+GHAY+VT ++ V ++ + +IR+RNPWG EWNG WSD++ E
Sbjct: 242 ARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEE 301
Query: 338 WEEVA-SDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYE 396
W++V+ S+ + + +DGEFWM+++D FT + C + + +K+ W
Sbjct: 302 WQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKT-WEEARLH 360
Query: 397 GSWR-----RGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQK 451
G+W R + GGC NH TF+ NPQ+ + E PED+ L+ + Q+
Sbjct: 361 GAWTLHEDPRQNRGGGCINHKDTFFQNPQY---IFEVKKPEDEV---------LICIQQR 408
Query: 452 NWRHARQQG-AQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSS 510
R R++G + IGF +Y V + Q +H Q S I+ NSR V
Sbjct: 409 PKRSTRREGKGENLAIGFDIYKVEENRQ--YRMH-------SLQHKAASSIYINSRSVFL 459
Query: 511 QLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWEL 549
+ P G Y+IIP+TFEP +FLLRVFT+ S EL
Sbjct: 460 RTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCREL 498
>gi|13186316 calpain 6 [Homo sapiens]
Length = 641
Score = 268 bits (685), Expect = 1e-71
Identities = 172/511 (33%), Positives = 266/511 (52%), Gaps = 59/511 (11%)
Query: 61 FGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPL 120
F NQ ++EL+ C++ LF DP F E SL + L P + W+RP+DI ++P
Sbjct: 8 FKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK-----VVWKRPQDICDDPH 62
Query: 121 FIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFK------KNYAGIFH 174
I+ IS + QG LG +++A L + +P + + + YAGIFH
Sbjct: 63 LIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFH 122
Query: 175 FQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGST 234
F+ W FG+W VV+DD LPT N LVF ST +EFW+ALLEKAYAKL G YEAL G +
Sbjct: 123 FRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTI 182
Query: 235 MEGLEDFTGGVAQSFQLQR--------PPQNLLRLLRKAVERSSLMGCSIEVTSDSELES 286
+ + DFTG +A++ +Q+ L L K + L+ CSIE + E E
Sbjct: 183 TDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEV 242
Query: 287 MTDKMLVRGHAYSVTGLQDVH--------YRGKMETLIRVRNPWGRIEWNGAWSDSAREW 338
TD L++GH Y++T ++ + + + ++R+RNP GR EW+G WS+ + EW
Sbjct: 243 ETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEW 302
Query: 339 EEV-ASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEG 397
+++ ASD + L ++DGEFWMS +DF NF L +C + + G + G
Sbjct: 303 QQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKE----LESVLG 358
Query: 398 SWRRG-----SSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKN 452
W + +GGC N+ TF NPQ+ ++PE +G+ V+ ++L QK+
Sbjct: 359 CWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPE--------DGHKVI----MSLQQKD 406
Query: 453 WRHARQQG-AQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKY-QDHGFSEIFTNSREVSS 510
R R+ G IGF L+ V +++ K Y Q+ + + ++R V
Sbjct: 407 LRTYRRMGRPDNYIIGFELFKV--------EMNRKFRLHHLYIQERAGTSTYIDTRTVFL 458
Query: 511 QLRLPPGEYIIIPSTFEPHRDADFLLRVFTE 541
L G Y+++P+ F+ R ++FLLR+F+E
Sbjct: 459 SKYLKKGNYVLVPTMFQHGRTSEFLLRIFSE 489
>gi|13186302 calpain 10 isoform a [Homo sapiens]
Length = 672
Score = 236 bits (603), Expect = 4e-62
Identities = 166/493 (33%), Positives = 237/493 (48%), Gaps = 47/493 (9%)
Query: 78 ELFEDPLFPAEPSSLGFKDLG-PNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGIL 136
ELF D FPA SSL F DL P ++ ++I+W+RP++I P D + QG+L
Sbjct: 12 ELFRDAAFPAADSSL-FCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLL 70
Query: 137 GDCWLLAAIGSLTTCPKLLYRVVPRGQSF--KKNYAGIFHFQIWQFGQWVNVVVDDRLPT 194
GDCW L A +L LL +V+P GQ + Y G F +IWQFG+WV V DDRLP
Sbjct: 71 GDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPC 130
Query: 195 KNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQ-- 252
+L F FW LLEK YAK+ GSYE L G + L D TGG+A+ + L+
Sbjct: 131 LAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGV 190
Query: 253 --------RPPQNLLRLLRKA--VERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTG 302
RP + R R+ ++ L+ C + E L HA+ V+
Sbjct: 191 AGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFHAFIVSD 244
Query: 303 LQDVH-YRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWMS 361
L+++ G+ L+R++NPWGR W G W + W +V + + +LL + ++GEFW+
Sbjct: 245 LRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVE 304
Query: 362 YQDFLNNFTLLEICNLTPDTLSGDYKSYW------HTTFYEGSWRRGSSAGGCRNHPGTF 415
++FL F L + P T +G +S + HT G+W +G SAGGCRN+ G F
Sbjct: 305 EEEFLREFDELTVG--YPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSG-F 361
Query: 416 WTNPQFKISLPEGDD--------PEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIG 467
+NP+F + + E + A LV +W A G Q +G
Sbjct: 362 PSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVG 421
Query: 468 FVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFE 527
L+ V K N+ V L H + REV + L PG Y+ +PSTF
Sbjct: 422 LHLWKVEKRRVNLPRV-LSMPPVAGTACHAY------DREVHLRCELSPGYYLAVPSTFL 474
Query: 528 PHRDADFLLRVFT 540
+FLLRVF+
Sbjct: 475 KDAPGEFLLRVFS 487
Score = 63.5 bits (153), Expect = 7e-10
Identities = 54/176 (30%), Positives = 76/176 (43%), Gaps = 25/176 (14%)
Query: 390 WHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALM 449
W T GSWR G +AGG RN ++ TNP F S+PEG P C+ +
Sbjct: 514 WGTVQLRGSWRVGQTAGGSRNF-ASYPTNPCFPFSVPEGPGPR-----------CVRITL 561
Query: 450 QKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQDVH--LKKEFFTKYQDHGFSEIFTNSRE 507
+H R + IGF ++ VP E QD L +E H +++ E
Sbjct: 562 H---QHCRPSDTEFHPIGFHIFQVP-EGGRSQDAPPLLLQEPLLSCVPHRYAQ------E 611
Query: 508 VSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKV 563
VS LP G Y ++PST+ P + F + + T S E+ + LQE V
Sbjct: 612 VSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEM-LGQFLQEVSV 666
>gi|89353291 calpain 10 isoform c [Homo sapiens]
Length = 517
Score = 231 bits (588), Expect = 2e-60
Identities = 170/518 (32%), Positives = 246/518 (47%), Gaps = 50/518 (9%)
Query: 78 ELFEDPLFPAEPSSLGFKDLG-PNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGIL 136
ELF D FPA SSL F DL P ++ ++I+W+RP++I P D + QG+L
Sbjct: 12 ELFRDAAFPAADSSL-FCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLL 70
Query: 137 GDCWLLAAIGSLTTCPKLLYRVVPRGQSF--KKNYAGIFHFQIWQFGQWVNVVVDDRLPT 194
GDCW L A +L LL +V+P GQ + Y G F +IWQFG+WV V DDRLP
Sbjct: 71 GDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPC 130
Query: 195 KNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQ-- 252
+L F FW LLEK YAK+ GSYE L G + L D TGG+A+ + L+
Sbjct: 131 LAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGV 190
Query: 253 --------RPPQNLLRLLRKA--VERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTG 302
RP + R R+ ++ L+ C + E L HA+ V+
Sbjct: 191 AGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFHAFIVSD 244
Query: 303 LQDVH-YRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWMS 361
L+++ G+ L+R++NPWGR W G W + W +V + + +LL + ++GEFW+
Sbjct: 245 LRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVE 304
Query: 362 YQDFLNNFTLLEICNLTPDTLSGDYKSYW------HTTFYEGSWRRGSSAGGCRNHPGTF 415
++FL F L + P T +G +S + HT G+W +G SAGGCRN+ G F
Sbjct: 305 EEEFLREFDELTVG--YPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSG-F 361
Query: 416 WTNPQFKISLPEGDD--------PEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIG 467
+NP+F + + E + A LV +W A G Q +G
Sbjct: 362 PSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVG 421
Query: 468 FVLYAVPKEFQNIQDVH--LKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPST 525
L+ VP E QD L +E H +++ EVS LP G Y ++PST
Sbjct: 422 LHLWKVP-EGGRSQDAPPLLLQEPLLSCVPHRYAQ------EVSRLCLLPAGTYKVVPST 474
Query: 526 FEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKV 563
+ P + F + + T S E+ + LQE V
Sbjct: 475 YLPDTEGAFTVTIATRIDRPSIHSQEM-LGQFLQEVSV 511
>gi|27765076 calpain 3 isoform d [Homo sapiens]
Length = 309
Score = 225 bits (573), Expect = 1e-58
Identities = 123/302 (40%), Positives = 170/302 (56%), Gaps = 47/302 (15%)
Query: 484 HLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKH 543
HL+K+FF S+ + N REVS + RLPP EY+I+PST+EPH++ +F+LRVF+EK
Sbjct: 7 HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 66
Query: 544 SESWEL----------------------DEVNYAEQLQEEKVSED--------------- 566
+ S E+ D N ++L ++ SE+
Sbjct: 67 NLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQ 126
Query: 567 ----------DMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACR 616
+ Q F ++FK +AG+ EI EL+++LN + K K KT GF L++CR
Sbjct: 127 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCR 186
Query: 617 CMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKL 676
MI LMD DGSGKL L EF LW K+K W IF+ D D SGT+NSYEMR + AG L
Sbjct: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246
Query: 677 NNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMT 736
NN++ ++ RYAD + IDFDSFI CF+RL+ MF F D G I L++ +WLQ+T
Sbjct: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 306
Query: 737 MW 738
M+
Sbjct: 307 MY 308
>gi|5032105 small optic lobes [Homo sapiens]
Length = 1086
Score = 168 bits (426), Expect = 1e-41
Identities = 115/340 (33%), Positives = 164/340 (48%), Gaps = 43/340 (12%)
Query: 66 FEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNI--SWQRPKDIINNPLF-- 121
+E + A C F D FP P S+GF P +VQ W RP++I N +F
Sbjct: 474 WENIVAFCRENNVSFVDDSFPPGPESVGF----PAGDSVQQRVRQWLRPQEI-NCSVFRD 528
Query: 122 ------IMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHF 175
+ + P+DI QG+LG+CW L+A+ L P L+ RV+ + G +
Sbjct: 529 HRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQV 585
Query: 176 QIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTM 235
++ + G W V+VDD LP + +R + W AL+EKA AKL GSY AL G +
Sbjct: 586 RLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAI 645
Query: 236 EGLEDFTGGVAQSFQLQRPPQN----------LLRLLRKAVERSSLMGCSI----EVTSD 281
EGL TG +S LQ N + + + E LMG S D
Sbjct: 646 EGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDD 705
Query: 282 SELESMTDKMLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEV 341
S ES+ L HAYS+ ++DV + L+R+RNPWGR WNG+WSD EW
Sbjct: 706 SAYESLG---LRPRHAYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSD---EWPHW 755
Query: 342 ASDIQMQLL-HKTEDGEFWMSYQDFLNNFTLLEICNLTPD 380
++ +L+ H + +G FWM Y DF+ F ++IC + D
Sbjct: 756 PGHLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICKVHSD 795
>gi|14161692 calpain small subunit 2 [Homo sapiens]
Length = 248
Score = 161 bits (408), Expect = 2e-39
Identities = 74/177 (41%), Positives = 118/177 (66%)
Query: 562 KVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINL 621
+ SE + + F F +AG E+G +L +LN++ K K KT GF LD CR ++++
Sbjct: 71 EASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFSLDTCRSIVSV 130
Query: 622 MDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVM 681
MD D +GKLG EFK LW +KKW ++++ D+DHSG+L S ++R ++ AG +LN ++
Sbjct: 131 MDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLY 190
Query: 682 QVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
Q++V RYA++D +DF++FISC +RL MF F ++D G I +S+++WLQ+TM+
Sbjct: 191 QMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMY 247
>gi|27765080 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 159 bits (402), Expect = 9e-39
Identities = 79/154 (51%), Positives = 101/154 (65%)
Query: 585 EIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKK 644
EI EL+++LN + K K KT GF L++CR MI LMD DGSGKL L EF LW K+K
Sbjct: 2 EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 61
Query: 645 WMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCF 704
W IF+ D D SGT+NSYEMR + AG LNN++ ++ RYAD + IDFDSFI CF
Sbjct: 62 WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 121
Query: 705 LRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
+RL+ MF F D G I L++ +WLQ+TM+
Sbjct: 122 VRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 155
>gi|27765078 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 159 bits (402), Expect = 9e-39
Identities = 79/154 (51%), Positives = 101/154 (65%)
Query: 585 EIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKK 644
EI EL+++LN + K K KT GF L++CR MI LMD DGSGKL L EF LW K+K
Sbjct: 2 EICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKA 61
Query: 645 WMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCF 704
W IF+ D D SGT+NSYEMR + AG LNN++ ++ RYAD + IDFDSFI CF
Sbjct: 62 WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCF 121
Query: 705 LRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
+RL+ MF F D G I L++ +WLQ+TM+
Sbjct: 122 VRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMY 155
>gi|4502565 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 156 bits (395), Expect = 6e-38
Identities = 71/177 (40%), Positives = 111/177 (62%)
Query: 562 KVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINL 621
+ +E + + F LF +AG+ E+ EL +LN++ + KT GFG+D CR M+ +
Sbjct: 91 EANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAV 150
Query: 622 MDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVM 681
MD D +GKLG EFK LW +K+W I+++ D D SGT+ S E+ E AG LN +
Sbjct: 151 MDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLY 210
Query: 682 QVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
+++ RY+D+ +DFD+FISC +RL MF F ++D TG I +++++WLQ+TM+
Sbjct: 211 NMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMY 267
>gi|51599151 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 156 bits (395), Expect = 6e-38
Identities = 71/177 (40%), Positives = 111/177 (62%)
Query: 562 KVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINL 621
+ +E + + F LF +AG+ E+ EL +LN++ + KT GFG+D CR M+ +
Sbjct: 91 EANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAV 150
Query: 622 MDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVM 681
MD D +GKLG EFK LW +K+W I+++ D D SGT+ S E+ E AG LN +
Sbjct: 151 MDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLY 210
Query: 682 QVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMW 738
+++ RY+D+ +DFD+FISC +RL MF F ++D TG I +++++WLQ+TM+
Sbjct: 211 NMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMY 267
>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
sapiens]
Length = 217
Score = 100 bits (248), Expect = 6e-21
Identities = 56/162 (34%), Positives = 86/162 (53%), Gaps = 4/162 (2%)
Query: 576 FKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEF 635
F VAG+ E+ ELQR L + I + F L+ CR MI ++D+D +GK+G F
Sbjct: 58 FSAVAGQDGEVDAEELQRCLTQSGI---NGTYSPFSLETCRIMIAMLDRDHTGKMGFNAF 114
Query: 636 KILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLII 695
K LW L W + F DQD SGT+ +E+R I G +L+ + + +V RY+ + I
Sbjct: 115 KELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIF 174
Query: 696 DFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTM 737
FD +++C ++L+ + FF D G + +LQ TM
Sbjct: 175 -FDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
>gi|7656959 calpain 7 [Homo sapiens]
Length = 813
Score = 92.4 bits (228), Expect = 1e-18
Identities = 84/353 (23%), Positives = 158/353 (44%), Gaps = 42/353 (11%)
Query: 97 LGPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLY 156
L P K + W RP+D+ NNP I +S I Q I+ DC +A++ +
Sbjct: 250 LSPKQKTTFS-KWVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFN 307
Query: 157 R------VVPRGQSFKKNY--AGIFHFQIWQFGQWVNVVVDDRLPTKND-KLVFVHSTER 207
+ + P+ + + Y G + ++ G V++DD+LP + +L+ +S +
Sbjct: 308 KKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNK 367
Query: 208 SEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQ-----NLLRLL 262
SE W +L+EKAY K+ G Y+ S ++ L TG + + + Q N R+L
Sbjct: 368 SELWVSLIEKAYMKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDSQTFSKDNSFRML 426
Query: 263 RKAVERSS-LMGCSIEVTSDSELESMTDKMLVRGHAYSVTGLQDVHYRGKMETLIRVRNP 321
+ + L+ S + +++E E LV HAY+V +++ K I+++NP
Sbjct: 427 YQRFHKGDVLITASTGMMTEAEGEKWG---LVPTHAYAVLDIREF----KGLRFIQLKNP 479
Query: 322 WGRIEWNGAWSDS-AREWE---EVASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNL 377
W + W G +S++ + W + + + K ++G FW+S+ D + ++
Sbjct: 480 WSHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVI----- 534
Query: 378 TPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKISL--PEG 428
LS + + +T +W + G + NPQ+K+ + P+G
Sbjct: 535 ---YLSWNPGLFKESTCIHSTW---DAKQGPVKDAYSLANNPQYKLEVQCPQG 581
>gi|38679884 sorcin isoform b [Homo sapiens]
Length = 183
Score = 90.5 bits (223), Expect = 5e-18
Identities = 51/162 (31%), Positives = 84/162 (51%), Gaps = 4/162 (2%)
Query: 576 FKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEF 635
F VAG+ +I ELQR L + I + K F L+ CR M++++D+D SG +G EF
Sbjct: 24 FAAVAGQDGQIDADELQRCLTQSGI---AGGYKPFNLETCRLMVSMLDRDMSGTMGFNEF 80
Query: 636 KILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLII 695
K LW L W F D D SGT++ E++ + G +L+ + + + RY+ + I
Sbjct: 81 KELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGK-I 139
Query: 696 DFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTM 737
FD +I+C ++L+ + F D G + + ++Q M
Sbjct: 140 TFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVM 181
>gi|4507207 sorcin isoform a [Homo sapiens]
Length = 198
Score = 90.5 bits (223), Expect = 5e-18
Identities = 51/162 (31%), Positives = 84/162 (51%), Gaps = 4/162 (2%)
Query: 576 FKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEF 635
F VAG+ +I ELQR L + I + K F L+ CR M++++D+D SG +G EF
Sbjct: 39 FAAVAGQDGQIDADELQRCLTQSGI---AGGYKPFNLETCRLMVSMLDRDMSGTMGFNEF 95
Query: 636 KILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLII 695
K LW L W F D D SGT++ E++ + G +L+ + + + RY+ + I
Sbjct: 96 KELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGK-I 154
Query: 696 DFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTM 737
FD +I+C ++L+ + F D G + + ++Q M
Sbjct: 155 TFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVM 196
>gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]
Length = 284
Score = 77.0 bits (188), Expect = 6e-14
Identities = 40/129 (31%), Positives = 72/129 (55%), Gaps = 2/129 (1%)
Query: 610 FGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVI 669
F + C MIN+ DK SG++ + F LWK +++W ++F++ D+D SG+++ E++ +
Sbjct: 151 FNDETCLMMINMFDKTKSGRIDVYGFSALWKFIQQWKNLFQQYDRDRSGSISYTELQQAL 210
Query: 670 EKAGIKLNNKVMQVLVARYA--DDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICL 727
+ G L+ + Q+LV+RY + + D FI +L+ + F D G+I L
Sbjct: 211 SQMGYNLSPQFTQLLVSRYCPRSANPAMQLDRFIQVCTQLQVLTEAFREKDTAVQGNIRL 270
Query: 728 SLEQWLQMT 736
S E ++ MT
Sbjct: 271 SFEDFVTMT 279
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,019,056
Number of Sequences: 37866
Number of extensions: 1385242
Number of successful extensions: 3453
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 3281
Number of HSP's gapped (non-prelim): 82
length of query: 739
length of database: 18,247,518
effective HSP length: 110
effective length of query: 629
effective length of database: 14,082,258
effective search space: 8857740282
effective search space used: 8857740282
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.