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Search of human proteins with 6912388
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
sapiens]
(217 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap... 450 e-127
gi|4507207 sorcin isoform a [Homo sapiens] 246 1e-65
gi|38679884 sorcin isoform b [Homo sapiens] 238 2e-63
gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens] 112 2e-25
gi|7019485 programmed cell death 6 [Homo sapiens] 108 5e-24
gi|215490104 calpain 11 [Homo sapiens] 100 1e-21
gi|4502565 calpain, small subunit 1 [Homo sapiens] 98 6e-21
gi|51599151 calpain, small subunit 1 [Homo sapiens] 98 6e-21
gi|47078247 calpain 3 isoform f [Homo sapiens] 97 1e-20
gi|4557405 calpain 3 isoform a [Homo sapiens] 97 1e-20
gi|27765072 calpain 3 isoform b [Homo sapiens] 97 1e-20
gi|27765076 calpain 3 isoform d [Homo sapiens] 97 1e-20
gi|27765074 calpain 3 isoform c [Homo sapiens] 97 1e-20
gi|14161692 calpain small subunit 2 [Homo sapiens] 95 4e-20
gi|157389005 calpain 2 isoform 1 [Homo sapiens] 92 3e-19
gi|225703100 calpain 2 isoform 2 [Homo sapiens] 92 3e-19
gi|221554549 calpain 8 [Homo sapiens] 92 3e-19
gi|7705383 calpain 9 isoform 2 [Homo sapiens] 89 3e-18
gi|5729758 calpain 9 isoform 1 [Homo sapiens] 89 3e-18
gi|12408656 calpain 1, large subunit [Homo sapiens] 89 3e-18
gi|27765080 calpain 3 isoform e [Homo sapiens] 86 2e-17
gi|27765078 calpain 3 isoform e [Homo sapiens] 86 2e-17
gi|38707981 calpain 12 [Homo sapiens] 66 3e-11
gi|41152101 calpain 13 [Homo sapiens] 56 2e-08
gi|223468608 calpain 14 [Homo sapiens] 55 6e-08
gi|223278387 calmodulin-like 5 [Homo sapiens] 48 6e-06
gi|4885111 calmodulin-like 3 [Homo sapiens] 40 0.001
gi|4757974 centrin 1 [Homo sapiens] 39 0.003
gi|76056882 calcium binding protein 1 isoform 3 [Homo sapiens] 38 0.008
gi|13929434 calcium binding protein 1 isoform 2 [Homo sapiens] 38 0.008
>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
sapiens]
Length = 217
Score = 450 bits (1157), Expect = e-127
Identities = 217/217 (100%), Positives = 217/217 (100%)
Query: 1 MAYPGYGGGFGNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSA 60
MAYPGYGGGFGNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSA
Sbjct: 1 MAYPGYGGGFGNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSA 60
Query: 61 VAGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAA 120
VAGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAA
Sbjct: 61 VAGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAA 120
Query: 121 LNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVA 180
LNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVA
Sbjct: 121 LNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVA 180
Query: 181 CCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI 217
CCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI
Sbjct: 181 CCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI 217
>gi|4507207 sorcin isoform a [Homo sapiens]
Length = 198
Score = 246 bits (628), Expect = 1e-65
Identities = 122/217 (56%), Positives = 153/217 (70%), Gaps = 19/217 (8%)
Query: 1 MAYPGYGGGFGNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSA 60
MAYPG+ G G + PG G P GPA+ D +Y YF+A
Sbjct: 1 MAYPGHPGAGGGY---YPGGYGGAP-------------GGPAFP---GQTQDPLYGYFAA 41
Query: 61 VAGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAA 120
VAGQDG++DA+ELQRCLTQSGI G Y PF+LETCR+M++MLDRD +G MGFN FKELWA
Sbjct: 42 VAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAV 101
Query: 121 LNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVA 180
LN W+++F++ D D SGTV+ EL++A+ MG+RLSPQ + +I KRYS NG+I FDDY+A
Sbjct: 102 LNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIA 161
Query: 181 CCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI 217
CCVKLRALTD FR+RD QQG NF YDDF+Q M++
Sbjct: 162 CCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 198
>gi|38679884 sorcin isoform b [Homo sapiens]
Length = 183
Score = 238 bits (608), Expect = 2e-63
Identities = 111/178 (62%), Positives = 140/178 (78%), Gaps = 3/178 (1%)
Query: 40 GPAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIA 99
GPA+ D +Y YF+AVAGQDG++DA+ELQRCLTQSGI G Y PF+LETCR+M++
Sbjct: 9 GPAFP---GQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVS 65
Query: 100 MLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQT 159
MLDRD +G MGFN FKELWA LN W+++F++ D D SGTV+ EL++A+ MG+RLSPQ
Sbjct: 66 MLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQA 125
Query: 160 LTTIVKRYSKNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI 217
+ +I KRYS NG+I FDDY+ACCVKLRALTD FR+RD QQG NF YDDF+Q M++
Sbjct: 126 VNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 183
>gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]
Length = 284
Score = 112 bits (280), Expect = 2e-25
Identities = 69/216 (31%), Positives = 111/216 (51%), Gaps = 22/216 (10%)
Query: 7 GGGFGNFSIQVPGMQMGQPVPET----GPAILLDGYSGPAYSDTYSSAGDSVYTYFSAV- 61
GG +G + PG GQP P + P + G + P + Y++F +V
Sbjct: 78 GGPYGGAA---PGGPYGQPPPSSYGAQQPGLYGQGGAPP-------NVDPEAYSWFQSVD 127
Query: 62 AGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAAL 121
+ G + +EL++ L +N +S F+ ETC +MI M D+ +G++ F LW +
Sbjct: 128 SDHSGYISMKELKQAL----VNCNWSSFNDETCLMMINMFDKTKSGRIDVYGFSALWKFI 183
Query: 122 NAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRY---SKNGRIFFDDY 178
WK F D+D SG++ + EL+QA+ MGY LSPQ +V RY S N + D +
Sbjct: 184 QQWKNLFQQYDRDRSGSISYTELQQALSQMGYNLSPQFTQLLVSRYCPRSANPAMQLDRF 243
Query: 179 VACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGT 214
+ C +L+ LT+ FR++D QG+ ++DF+ T
Sbjct: 244 IQVCTQLQVLTEAFREKDTAVQGNIRLSFEDFVTMT 279
>gi|7019485 programmed cell death 6 [Homo sapiens]
Length = 191
Score = 108 bits (269), Expect = 5e-24
Identities = 55/156 (35%), Positives = 91/156 (58%), Gaps = 6/156 (3%)
Query: 64 QDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNA 123
+ G + ELQ+ L+ NGT++PF+ T R +I+M DR++ + F+ F +W +
Sbjct: 39 RSGVISDTELQQALS----NGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITD 94
Query: 124 WKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGR--IFFDDYVAC 181
W+ F T D+D SG ++ +EL+QA+ GYRLS Q +++++ + GR I FDD++
Sbjct: 95 WQNVFRTYDRDNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQG 154
Query: 182 CVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI 217
C+ L+ LTD FR+ D Q G Y+ +L +I
Sbjct: 155 CIVLQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSI 190
Score = 27.7 bits (60), Expect = 7.8
Identities = 18/77 (23%), Positives = 35/77 (45%), Gaps = 3/77 (3%)
Query: 128 FMTVDQDGSGTVEHHELRQAIGLMGYR-LSPQTLTTIVKRYSKNGR--IFFDDYVACCVK 184
F VD+D SG + EL+QA+ + +P T+ +I+ + + + + F ++
Sbjct: 32 FQRVDKDRSGVISDTELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKY 91
Query: 185 LRALTDFFRKRDHLQQG 201
+ + FR D G
Sbjct: 92 ITDWQNVFRTYDRDNSG 108
>gi|215490104 calpain 11 [Homo sapiens]
Length = 739
Score = 100 bits (248), Expect = 1e-21
Identities = 56/162 (34%), Positives = 86/162 (53%), Gaps = 4/162 (2%)
Query: 58 FSAVAGQDGEVDAEELQRCLTQSGI---NGTYSPFSLETCRIMIAMLDRDHTGKMGFNAF 114
F VAG+ E+ ELQR L + I + F L+ CR MI ++D+D +GK+G F
Sbjct: 576 FKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEF 635
Query: 115 KELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIF 174
K LW L W + F DQD SGT+ +E+R I G +L+ + + +V RY+ + I
Sbjct: 636 KILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLII 695
Query: 175 -FDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
FD +++C ++L+ + FF D G + +LQ TM
Sbjct: 696 DFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTM 737
>gi|4502565 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 97.8 bits (242), Expect = 6e-21
Identities = 59/180 (32%), Positives = 93/180 (51%), Gaps = 7/180 (3%)
Query: 43 YSDTYSSAGDSVYTY---FSAVAGQDGEVDAEELQRCLTQSGINGT---YSPFSLETCRI 96
YS+ ++ + V + F+ +AG D EV A EL L + F ++TCR
Sbjct: 87 YSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRS 146
Query: 97 MIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLS 156
M+A++D D TGK+GF FK LW + W+ + D D SGT+ EL A G+ L+
Sbjct: 147 MVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLN 206
Query: 157 PQTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
I++RYS ++G + FD++++C V+L A+ F+ D G ++LQ TM
Sbjct: 207 EHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTM 266
>gi|51599151 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 97.8 bits (242), Expect = 6e-21
Identities = 59/180 (32%), Positives = 93/180 (51%), Gaps = 7/180 (3%)
Query: 43 YSDTYSSAGDSVYTY---FSAVAGQDGEVDAEELQRCLTQSGINGT---YSPFSLETCRI 96
YS+ ++ + V + F+ +AG D EV A EL L + F ++TCR
Sbjct: 87 YSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRS 146
Query: 97 MIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLS 156
M+A++D D TGK+GF FK LW + W+ + D D SGT+ EL A G+ L+
Sbjct: 147 MVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLN 206
Query: 157 PQTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
I++RYS ++G + FD++++C V+L A+ F+ D G ++LQ TM
Sbjct: 207 EHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTM 266
>gi|47078247 calpain 3 isoform f [Homo sapiens]
Length = 728
Score = 96.7 bits (239), Expect = 1e-20
Identities = 60/180 (33%), Positives = 90/180 (50%), Gaps = 6/180 (3%)
Query: 41 PAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYS----PFSLETCRI 96
P SD S F +AG D E+ A+EL++ L + +N F+LE+CR
Sbjct: 548 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLN-TVVNKHKDLKTHGFTLESCRS 606
Query: 97 MIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLS 156
MIA++D D +GK+ F LW + AW++ F D D SGT+ +E+R A+ G+ L+
Sbjct: 607 MIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLN 666
Query: 157 PQTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
Q I RY+ K+ I FD ++ C V+L + F D G ++LQ TM
Sbjct: 667 NQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 726
>gi|4557405 calpain 3 isoform a [Homo sapiens]
Length = 821
Score = 96.7 bits (239), Expect = 1e-20
Identities = 60/180 (33%), Positives = 90/180 (50%), Gaps = 6/180 (3%)
Query: 41 PAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYS----PFSLETCRI 96
P SD S F +AG D E+ A+EL++ L + +N F+LE+CR
Sbjct: 641 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLN-TVVNKHKDLKTHGFTLESCRS 699
Query: 97 MIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLS 156
MIA++D D +GK+ F LW + AW++ F D D SGT+ +E+R A+ G+ L+
Sbjct: 700 MIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLN 759
Query: 157 PQTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
Q I RY+ K+ I FD ++ C V+L + F D G ++LQ TM
Sbjct: 760 NQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 819
>gi|27765072 calpain 3 isoform b [Homo sapiens]
Length = 815
Score = 96.7 bits (239), Expect = 1e-20
Identities = 60/180 (33%), Positives = 90/180 (50%), Gaps = 6/180 (3%)
Query: 41 PAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYS----PFSLETCRI 96
P SD S F +AG D E+ A+EL++ L + +N F+LE+CR
Sbjct: 635 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLN-TVVNKHKDLKTHGFTLESCRS 693
Query: 97 MIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLS 156
MIA++D D +GK+ F LW + AW++ F D D SGT+ +E+R A+ G+ L+
Sbjct: 694 MIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLN 753
Query: 157 PQTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
Q I RY+ K+ I FD ++ C V+L + F D G ++LQ TM
Sbjct: 754 NQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 813
>gi|27765076 calpain 3 isoform d [Homo sapiens]
Length = 309
Score = 96.7 bits (239), Expect = 1e-20
Identities = 60/180 (33%), Positives = 90/180 (50%), Gaps = 6/180 (3%)
Query: 41 PAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYS----PFSLETCRI 96
P SD S F +AG D E+ A+EL++ L + +N F+LE+CR
Sbjct: 129 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLN-TVVNKHKDLKTHGFTLESCRS 187
Query: 97 MIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLS 156
MIA++D D +GK+ F LW + AW++ F D D SGT+ +E+R A+ G+ L+
Sbjct: 188 MIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLN 247
Query: 157 PQTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
Q I RY+ K+ I FD ++ C V+L + F D G ++LQ TM
Sbjct: 248 NQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 307
>gi|27765074 calpain 3 isoform c [Homo sapiens]
Length = 729
Score = 96.7 bits (239), Expect = 1e-20
Identities = 60/180 (33%), Positives = 90/180 (50%), Gaps = 6/180 (3%)
Query: 41 PAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYS----PFSLETCRI 96
P SD S F +AG D E+ A+EL++ L + +N F+LE+CR
Sbjct: 549 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLN-TVVNKHKDLKTHGFTLESCRS 607
Query: 97 MIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLS 156
MIA++D D +GK+ F LW + AW++ F D D SGT+ +E+R A+ G+ L+
Sbjct: 608 MIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLN 667
Query: 157 PQTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
Q I RY+ K+ I FD ++ C V+L + F D G ++LQ TM
Sbjct: 668 NQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 727
>gi|14161692 calpain small subunit 2 [Homo sapiens]
Length = 248
Score = 95.1 bits (235), Expect = 4e-20
Identities = 65/218 (29%), Positives = 111/218 (50%), Gaps = 17/218 (7%)
Query: 5 GYGGGFGNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTY---FSAV 61
G GG NF + Q PE P + ++ +S + V + F+ +
Sbjct: 39 GIVGGIVNFISEAAAAQY---TPEPPP-------TQQHFTSVEASESEEVRRFRQQFTQL 88
Query: 62 AGQDGEVDAEELQRCLTQ---SGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELW 118
AG D EV A +L L + + FSL+TCR +++++D D TGK+GF FK LW
Sbjct: 89 AGPDMEVGATDLMNILNKVLSKHKDLKTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLW 148
Query: 119 AALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRY-SKNGRIFFDD 177
+ W+ + D+D SG++ +LR A+ G++L+ Q IV+RY +++G + F++
Sbjct: 149 NNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNN 208
Query: 178 YVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
+++C V+L A+ F+ D + G ++LQ TM
Sbjct: 209 FISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTM 246
>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
Length = 700
Score = 92.4 bits (228), Expect = 3e-19
Identities = 52/155 (33%), Positives = 86/155 (55%), Gaps = 4/155 (2%)
Query: 52 DSVYTYFSAVAGQDGEVDAEELQRCLTQ---SGINGTYSPFSLETCRIMIAMLDRDHTGK 108
D F+ +AG+D E+ A ELQ L + + FS+ETC+IM+ MLD D +GK
Sbjct: 532 DGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGK 591
Query: 109 MGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYS 168
+G F LW + +++ + +D D SGT+ +E+R+A+ G+++ Q IV R++
Sbjct: 592 LGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFA 651
Query: 169 KNGRIF-FDDYVACCVKLRALTDFFRKRDHLQQGS 202
+ I FD++V C V+L L F++ D G+
Sbjct: 652 DDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGT 686
>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
Length = 622
Score = 92.4 bits (228), Expect = 3e-19
Identities = 52/155 (33%), Positives = 86/155 (55%), Gaps = 4/155 (2%)
Query: 52 DSVYTYFSAVAGQDGEVDAEELQRCLTQ---SGINGTYSPFSLETCRIMIAMLDRDHTGK 108
D F+ +AG+D E+ A ELQ L + + FS+ETC+IM+ MLD D +GK
Sbjct: 454 DGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGK 513
Query: 109 MGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYS 168
+G F LW + +++ + +D D SGT+ +E+R+A+ G+++ Q IV R++
Sbjct: 514 LGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFA 573
Query: 169 KNGRIF-FDDYVACCVKLRALTDFFRKRDHLQQGS 202
+ I FD++V C V+L L F++ D G+
Sbjct: 574 DDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGT 608
>gi|221554549 calpain 8 [Homo sapiens]
Length = 703
Score = 92.0 bits (227), Expect = 3e-19
Identities = 63/206 (30%), Positives = 99/206 (48%), Gaps = 9/206 (4%)
Query: 11 GNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSAVAGQDGEVDA 70
G F ++V + Q + E G + + Y + D F +AG+D E+ A
Sbjct: 497 GEFCLRVFSEKKAQAL-EIGDVVAGNPYE--PHPSEVDQEDDQFRRLFEKLAGKDSEITA 553
Query: 71 EELQRCLTQSGINGT---YSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKEN 127
L+ L ++ T + F++ TCR MI++LD + TG +G FK LW + + E
Sbjct: 554 NALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEI 613
Query: 128 FMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRY--SKNGRIFFDDYVACCVKL 185
+ D + SGT++ HE+R A+ G+ L+ Q TI RY SK G I FD +VAC ++L
Sbjct: 614 YWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLG-INFDSFVACMIRL 672
Query: 186 RALTDFFRKRDHLQQGSANFIYDDFL 211
L F D + G ++L
Sbjct: 673 ETLFKLFSLLDEDKDGMVQLSLAEWL 698
>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
Length = 664
Score = 89.0 bits (219), Expect = 3e-18
Identities = 55/164 (33%), Positives = 87/164 (53%), Gaps = 4/164 (2%)
Query: 58 FSAVAGQDGEVDAEELQRCLT---QSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAF 114
F VAG+D EV AEEL+ L Q + + SL +C+ +I+++D GK+ F+ F
Sbjct: 501 FEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEF 560
Query: 115 KELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYS-KNGRI 173
K W L W F+ D D SGT+ +ELR A+ G++LS L IV RY+ + ++
Sbjct: 561 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 620
Query: 174 FFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI 217
FDD++ C V+L + F+ + + ++F+ TM I
Sbjct: 621 DFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI 664
>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
Length = 690
Score = 89.0 bits (219), Expect = 3e-18
Identities = 55/164 (33%), Positives = 87/164 (53%), Gaps = 4/164 (2%)
Query: 58 FSAVAGQDGEVDAEELQRCLT---QSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAF 114
F VAG+D EV AEEL+ L Q + + SL +C+ +I+++D GK+ F+ F
Sbjct: 527 FEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEF 586
Query: 115 KELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYS-KNGRI 173
K W L W F+ D D SGT+ +ELR A+ G++LS L IV RY+ + ++
Sbjct: 587 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 646
Query: 174 FFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI 217
FDD++ C V+L + F+ + + ++F+ TM I
Sbjct: 647 DFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI 690
>gi|12408656 calpain 1, large subunit [Homo sapiens]
Length = 714
Score = 89.0 bits (219), Expect = 3e-18
Identities = 54/162 (33%), Positives = 86/162 (53%), Gaps = 4/162 (2%)
Query: 58 FSAVAGQDGEVDAEELQRCLTQ---SGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAF 114
F +AG+D E+ +EL+ L + + FSLE+CR M+ ++DRD GK+G F
Sbjct: 551 FRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEF 610
Query: 115 KELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSK-NGRI 173
LW + + F D D SG++ +E+R AI G++L+ + I+ RYS+ + +
Sbjct: 611 NILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAV 670
Query: 174 FFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215
FD++V C V+L + FF+ D G F +LQ TM
Sbjct: 671 DFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTM 712
>gi|27765080 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 85.9 bits (211), Expect = 2e-17
Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 1/128 (0%)
Query: 89 FSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAI 148
F+LE+CR MIA++D D +GK+ F LW + AW++ F D D SGT+ +E+R A+
Sbjct: 27 FTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAV 86
Query: 149 GLMGYRLSPQTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIY 207
G+ L+ Q I RY+ K+ I FD ++ C V+L + F D G
Sbjct: 87 NDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNV 146
Query: 208 DDFLQGTM 215
++LQ TM
Sbjct: 147 LEWLQLTM 154
>gi|27765078 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 85.9 bits (211), Expect = 2e-17
Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 1/128 (0%)
Query: 89 FSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAI 148
F+LE+CR MIA++D D +GK+ F LW + AW++ F D D SGT+ +E+R A+
Sbjct: 27 FTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAV 86
Query: 149 GLMGYRLSPQTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIY 207
G+ L+ Q I RY+ K+ I FD ++ C V+L + F D G
Sbjct: 87 NDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNV 146
Query: 208 DDFLQGTM 215
++LQ TM
Sbjct: 147 LEWLQLTM 154
>gi|38707981 calpain 12 [Homo sapiens]
Length = 719
Score = 65.9 bits (159), Expect = 3e-11
Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 10/150 (6%)
Query: 58 FSAVAGQDGEVDAEELQRCLTQS-----GINGTYSPFSLETCRIMIAMLDRDHTGKMGFN 112
F +AG++ E++A +LQ L+ + T L TC ++ H + +
Sbjct: 556 FQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQLLQCFG--HGQSLALH 613
Query: 113 AFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNG- 171
F++LW L W+ F D+D SGT+ +ELR A+ G+ L+ Q T+ RY +
Sbjct: 614 HFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRL 673
Query: 172 RIFFDDYVACCVKLRALTDFFRKRDHLQQG 201
R+ F+ +V+C L + F HL G
Sbjct: 674 RVDFERFVSCVAHLTCI--FCHCSQHLDGG 701
>gi|41152101 calpain 13 [Homo sapiens]
Length = 669
Score = 56.2 bits (134), Expect = 2e-08
Identities = 44/147 (29%), Positives = 71/147 (48%), Gaps = 7/147 (4%)
Query: 53 SVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYSP-FSLETCRIMIAMLDRDHTGKMGF 111
S + F+ A Q ++DA +LQ L Q + G FSL+ CR ++A+++ G++
Sbjct: 501 SQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSLDECRSLVALMELKVNGRLDQ 560
Query: 112 NAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIG----LMGYRLSPQTLTTIVKRY 167
F LW L ++ F V Q G + +L +AI L G +S + L + RY
Sbjct: 561 EEFARLWKRLVHYQHVFQKV-QTSPGVLLSSDLWKAIENTDFLRGIFISRELLHLVTLRY 619
Query: 168 SKN-GRIFFDDYVACCVKLRALTDFFR 193
S + GR+ F V ++L A+ FR
Sbjct: 620 SDSVGRVSFPSLVCFLMRLEAMAKTFR 646
>gi|223468608 calpain 14 [Homo sapiens]
Length = 684
Score = 54.7 bits (130), Expect = 6e-08
Identities = 40/159 (25%), Positives = 74/159 (46%), Gaps = 5/159 (3%)
Query: 39 SGPAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQ---SGINGTYSPFSLETCR 95
SG +S + +F+ + E++A +LQ L Q S + FSLE C+
Sbjct: 504 SGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQNLLNQMTWSSLGSRQPFFSLEACQ 563
Query: 96 IMIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRL 155
++A+LD + +G M F++LW L ++ F D+ GSG + +L A+ G L
Sbjct: 564 GILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDR-GSGYLNWEQLHAAMREAGIML 622
Query: 156 SPQTLTTIVKRY-SKNGRIFFDDYVACCVKLRALTDFFR 193
S ++ RY ++ F ++ +++ + D F+
Sbjct: 623 SDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQ 661
>gi|223278387 calmodulin-like 5 [Homo sapiens]
Length = 146
Score = 48.1 bits (113), Expect = 6e-06
Identities = 37/128 (28%), Positives = 64/128 (50%), Gaps = 12/128 (9%)
Query: 58 FSAV-AGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAF-- 114
FSAV +G ++A+EL L +G N S R +I+ +D D G++ F F
Sbjct: 17 FSAVDTDGNGTINAQELGAALKATGKN-----LSEAQLRKLISEVDSDGDGEISFQEFLT 71
Query: 115 --KELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKR--YSKN 170
K+ A L + F DQDG G + ELR+A+ +G L + L +++ ++
Sbjct: 72 AAKKARAGLEDLQVAFRAFDQDGDGHITVDELRRAMAGLGQPLPQEELDAMIREADVDQD 131
Query: 171 GRIFFDDY 178
GR+ ++++
Sbjct: 132 GRVNYEEF 139
Score = 38.5 bits (88), Expect = 0.004
Identities = 28/92 (30%), Positives = 41/92 (44%), Gaps = 8/92 (8%)
Query: 124 WKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSK--NGRIFFDDYVAC 181
+K+ F VD DG+GT+ EL A+ G LS L ++ +G I F +++
Sbjct: 13 YKKAFSAVDTDGNGTINAQELGAALKATGKNLSEAQLRKLISEVDSDGDGEISFQEFLTA 72
Query: 182 CVKLRA----LTDFFRKRDHLQQGSANFIYDD 209
K RA L FR D Q G + D+
Sbjct: 73 AKKARAGLEDLQVAFRAFD--QDGDGHITVDE 102
>gi|4885111 calmodulin-like 3 [Homo sapiens]
Length = 149
Score = 40.4 bits (93), Expect = 0.001
Identities = 32/128 (25%), Positives = 58/128 (45%), Gaps = 14/128 (10%)
Query: 65 DGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAAL--- 121
DG + EL + G N T + R M++ +DRD G + F F + A
Sbjct: 25 DGCITTRELGTVMRSLGQNPTEAEL-----RDMMSEIDRDGNGTVDFPEFLGMMARKMKD 79
Query: 122 ----NAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSK--NGRIFF 175
+E F D+DG+G V ELR + +G +LS + + +++ +G++ +
Sbjct: 80 TDNEEEIREAFRVFDKDGNGFVSAAELRHVMTRLGEKLSDEEVDEMIRAADTDGDGQVNY 139
Query: 176 DDYVACCV 183
+++V V
Sbjct: 140 EEFVRVLV 147
>gi|4757974 centrin 1 [Homo sapiens]
Length = 172
Score = 39.3 bits (90), Expect = 0.003
Identities = 28/113 (24%), Positives = 52/113 (46%), Gaps = 12/113 (10%)
Query: 66 GEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWK 125
G +DA+EL+ + G + P E + MI+ +DR+ TGK+ FN F + + K
Sbjct: 46 GTIDAKELKVAMRALG----FEPRK-EEMKKMISEVDREGTGKISFNDFLAVMTQKMSEK 100
Query: 126 EN-------FMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNG 171
+ F D D +G + L++ +G L+ + L ++ ++G
Sbjct: 101 DTKEEILKAFRLFDDDETGKISFKNLKRVANELGENLTDEELQEMIDEADRDG 153
Score = 35.4 bits (80), Expect = 0.038
Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 2/58 (3%)
Query: 125 KENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSK--NGRIFFDDYVA 180
+E F D DGSGT++ EL+ A+ +G+ + + ++ + G+I F+D++A
Sbjct: 34 REAFDLFDVDGSGTIDAKELKVAMRALGFEPRKEEMKKMISEVDREGTGKISFNDFLA 91
>gi|76056882 calcium binding protein 1 isoform 3 [Homo sapiens]
Length = 370
Score = 37.7 bits (86), Expect = 0.008
Identities = 29/130 (22%), Positives = 60/130 (46%), Gaps = 19/130 (14%)
Query: 64 QDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWA---- 119
+DG ++ +L C+ G Y P +E + ++ + G + F+ F EL
Sbjct: 241 KDGYINCRDLGNCMRTMG----YMPTEMELIELS-QQINMNLGGHVDFDDFVELMGPKLL 295
Query: 120 -------ALNAWKENFMTVDQDGSGTVEHHELRQAI-GLMGYRLSPQTLTTIVKRYSKN- 170
+ ++ F D +G G + ELR+A+ L+G+++ + + I++ N
Sbjct: 296 AETADMIGVKELRDAFREFDTNGDGEISTSELREAMRKLLGHQVGHRDIEEIIRDVDLNG 355
Query: 171 -GRIFFDDYV 179
GR+ F+++V
Sbjct: 356 DGRVDFEEFV 365
Score = 30.8 bits (68), Expect = 0.92
Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 13/85 (15%)
Query: 125 KENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKN--GRIFFDDYV--- 179
+E F D+D G + +L + MGY + L + ++ + N G + FDD+V
Sbjct: 231 REAFREFDKDKDGYINCRDLGNCMRTMGYMPTEMELIELSQQINMNLGGHVDFDDFVELM 290
Query: 180 --------ACCVKLRALTDFFRKRD 196
A + ++ L D FR+ D
Sbjct: 291 GPKLLAETADMIGVKELRDAFREFD 315
>gi|13929434 calcium binding protein 1 isoform 2 [Homo sapiens]
Length = 167
Score = 37.7 bits (86), Expect = 0.008
Identities = 29/130 (22%), Positives = 60/130 (46%), Gaps = 19/130 (14%)
Query: 64 QDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWA---- 119
+DG ++ +L C+ G Y P +E + ++ + G + F+ F EL
Sbjct: 38 KDGYINCRDLGNCMRTMG----YMPTEMELIELS-QQINMNLGGHVDFDDFVELMGPKLL 92
Query: 120 -------ALNAWKENFMTVDQDGSGTVEHHELRQAI-GLMGYRLSPQTLTTIVKRYSKN- 170
+ ++ F D +G G + ELR+A+ L+G+++ + + I++ N
Sbjct: 93 AETADMIGVKELRDAFREFDTNGDGEISTSELREAMRKLLGHQVGHRDIEEIIRDVDLNG 152
Query: 171 -GRIFFDDYV 179
GR+ F+++V
Sbjct: 153 DGRVDFEEFV 162
Score = 30.8 bits (68), Expect = 0.92
Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 13/85 (15%)
Query: 125 KENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKN--GRIFFDDYV--- 179
+E F D+D G + +L + MGY + L + ++ + N G + FDD+V
Sbjct: 28 REAFREFDKDKDGYINCRDLGNCMRTMGYMPTEMELIELSQQINMNLGGHVDFDDFVELM 87
Query: 180 --------ACCVKLRALTDFFRKRD 196
A + ++ L D FR+ D
Sbjct: 88 GPKLLAETADMIGVKELRDAFREFD 112
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,754,960
Number of Sequences: 37866
Number of extensions: 386985
Number of successful extensions: 1034
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 919
Number of HSP's gapped (non-prelim): 91
length of query: 217
length of database: 18,247,518
effective HSP length: 98
effective length of query: 119
effective length of database: 14,536,650
effective search space: 1729861350
effective search space used: 1729861350
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.