Search of human proteins with 13186316

Search of human proteins with 13186316

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13186316 calpain 6 [Homo sapiens]
         (641 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13186316 calpain 6 [Homo sapiens]                                 1332   0.0  
gi|37577157 calpain 5 [Homo sapiens]                                  599   e-171
gi|27765074 calpain 3 isoform c [Homo sapiens]                        313   3e-85
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                         296   4e-80
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       294   2e-79
gi|4557405 calpain 3 isoform a [Homo sapiens]                         293   4e-79
gi|27765072 calpain 3 isoform b [Homo sapiens]                        293   4e-79
gi|221554549 calpain 8 [Homo sapiens]                                 290   2e-78
gi|12408656 calpain 1, large subunit [Homo sapiens]                   270   3e-72
gi|215490104 calpain 11 [Homo sapiens]                                268   1e-71
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       264   2e-70
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                         258   1e-68
gi|47078247 calpain 3 isoform f [Homo sapiens]                        251   2e-66
gi|223468608 calpain 14 [Homo sapiens]                                229   5e-60
gi|38707981 calpain 12 [Homo sapiens]                                 229   5e-60
gi|13186302 calpain 10 isoform a [Homo sapiens]                       180   4e-45
gi|41152101 calpain 13 [Homo sapiens]                                 177   3e-44
gi|89353291 calpain 10 isoform c [Homo sapiens]                       155   1e-37
gi|7656959 calpain 7 [Homo sapiens]                                   102   1e-21
gi|5032105 small optic lobes [Homo sapiens]                            96   1e-19
gi|27765076 calpain 3 isoform d [Homo sapiens]                         40   0.005
gi|13186314 calpain 10 isoform g [Homo sapiens]                        39   0.019
gi|7662394 RAB11 family interacting protein 2 (class I) [Homo sa...    37   0.043
gi|122937514 unc-13 homolog C [Homo sapiens]                           37   0.056
gi|168823435 hypothetical protein LOC79747 [Homo sapiens]              36   0.096
gi|122937247 unc-13 homolog A [Homo sapiens]                           32   1.4  
gi|16757970 niban protein isoform 2 [Homo sapiens]                     31   4.0  
gi|221316654 neuropeptide FF receptor 2 isoform 1 [Homo sapiens]       30   5.2  
gi|7657455 pescadillo homolog 1, containing BRCT domain [Homo sa...    30   6.8  
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]                    30   6.8  

>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score = 1332 bits (3448), Expect = 0.0
 Identities = 641/641 (100%), Positives = 641/641 (100%)

Query: 1   MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDD 60
           MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDD
Sbjct: 1   MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDD 60

Query: 61  PHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGI 120
           PHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGI
Sbjct: 61  PHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGI 120

Query: 121 FHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGL 180
           FHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGL
Sbjct: 121 FHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGL 180

Query: 181 TITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQ 240
           TITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQ
Sbjct: 181 TITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQ 240

Query: 241 EVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISE 300
           EVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISE
Sbjct: 241 EVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISE 300

Query: 301 EWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCW 360
           EWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCW
Sbjct: 301 EWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCW 360

Query: 361 TVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYI 420
           TVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYI
Sbjct: 361 TVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYI 420

Query: 421 IGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTS 480
           IGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTS
Sbjct: 421 IGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTS 480

Query: 481 EFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPY 540
           EFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPY
Sbjct: 481 EFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPY 540

Query: 541 LVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDA 600
           LVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDA
Sbjct: 541 LVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDA 600

Query: 601 DPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL 641
           DPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL
Sbjct: 601 DPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL 641


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  599 bits (1545), Expect = e-171
 Identities = 296/637 (46%), Positives = 416/637 (65%), Gaps = 7/637 (1%)

Query: 5   LKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLI 64
           +K +++Q Y  L+++C +   LF DP F   +DSL+Y       V WKRP+ IC+DP L 
Sbjct: 5   VKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLF 64

Query: 65  VGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFR 124
           V  IS+H L QG++G+   V+A S LA +ES W K IP+ KEQEWDP+K   YAGIFHF 
Sbjct: 65  VDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFH 124

Query: 125 FWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITD 184
           FW FGEW +VVIDD LPT+N  L++  S S NEFW AL+EKAYAKL GCY+ALDG    D
Sbjct: 125 FWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTAD 184

Query: 185 IIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVET 244
            +VDFTG ++E +D+ +G +     ++ +LF  + K  ++GGLI  SI++    + E   
Sbjct: 185 ALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARL 244

Query: 245 DWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQ 304
             GL+KGH Y +TD+RK+RLG  L+  F +EK+ M+RLRNP G +EW+GPWS+ SEEWQ+
Sbjct: 245 ACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQK 304

Query: 305 LTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNN---PIFGRKELESVLGCWT 361
           ++ S+R+ +G+ + DDGEFWM+ ED CR F  +  CR +N     I    E   + G WT
Sbjct: 305 VSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWT 364

Query: 362 VDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYII 421
           + +DP  NR GGC N++DTF QNPQYIF V +   +V++ +QQ+  R+ RR G+ +N  I
Sbjct: 365 LHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAI 424

Query: 422 GFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSE 481
           GF+++KVE NR++R+H L  Q +A +S YI++R+VFL     +G YV++PT F+ G T E
Sbjct: 425 GFDIYKVEENRQYRMHSL--QHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGE 482

Query: 482 FLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPYL 541
           FLLR+F++VP   REL LD P  +CW+   GYP++VTQ+ V  A  L  K +    N Y+
Sbjct: 483 FLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGL--KDSPTGANSYV 540

Query: 542 VIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDAD 601
           +IKC  ++VRS VQK T    ++ + IFYR+    PI VQVWN R   D+FLGQV L AD
Sbjct: 541 IIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKAD 600

Query: 602 PSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDL 638
           P + + L +L+LR +         G ++  ++SS  L
Sbjct: 601 PDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSL 637


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score =  313 bits (802), Expect = 3e-85
 Identities = 183/505 (36%), Positives = 279/505 (55%), Gaps = 47/505 (9%)

Query: 4   PLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHL 63
           P+   K + +++L ++C++   L+ DP F P+  SLFY++  P + VWKRP +IC++P  
Sbjct: 52  PIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRF 111

Query: 64  IVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHF 123
           I+   +   + QG LG    ++A +CL + +    + IP+      D    E YAGIFHF
Sbjct: 112 IIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHF 165

Query: 124 RFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTIT 183
           +FW +GEW +VVIDD LPT N  LVF+ S   NEFW+ALLEKAYAKL G YEAL G   T
Sbjct: 166 QFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTT 225

Query: 184 DIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVE 243
           + + DFTG +AE  +++     +   + YK+   + K   +G L+ CSI++    + E  
Sbjct: 226 EAMEDFTGGVAEFFEIR-----DAPSDMYKI---MKKAIERGSLMGCSIDTIIPVQYETR 277

Query: 244 TDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQ 303
              GL++GH Y++T + ++         F  EKV +VRLRNP G+ EW+G WS+  ++W 
Sbjct: 278 MACGLVRGHAYSVTGLDEV--------PFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWS 329

Query: 304 QLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVD 363
            +   ++  L   +++DGEFWMS EDF  +F KL +C    + +   K     L  WTV 
Sbjct: 330 FVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDK-----LQTWTVS 384

Query: 364 -DDPLMNR---SGGCYNNRDTFLQNPQYIFTV------PEDGHKV---IMSLQQKDLRTY 410
            ++    R   +GGC N  DTF  NPQY   +      P+D   +   +++L QK+ R  
Sbjct: 385 VNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKD 444

Query: 411 RRMGRPDNYIIGFELFKVEMNRKFRLHH------LYIQERAGTSTYIDTRTVFLSKYLKK 464
           R++G    + IGF +++V         H      LY   +A + TYI+ R V     L  
Sbjct: 445 RKLG-ASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPP 503

Query: 465 GNYVLVPTMFQHGRTSEFLLRIFSE 489
             YV+VP+ ++  +  EF+LR+FSE
Sbjct: 504 SEYVIVPSTYEPHQEGEFILRVFSE 528


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score =  296 bits (758), Expect = 4e-80
 Identities = 178/511 (34%), Positives = 275/511 (53%), Gaps = 49/511 (9%)

Query: 11  QKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIVGNISN 70
           Q +++++QEC++   LF D  F   N SLFY+       VWKRP +I  +P  I+G  + 
Sbjct: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATR 86

Query: 71  HQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGE 130
             + QG LG   +++A + L + +    + IP  ++Q + P     YAGIFHF+FW   E
Sbjct: 87  TDICQGELGDCWLLAAIASLTLNQKALARVIP--QDQSFGPG----YAGIFHFQFWQHSE 140

Query: 131 WTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFT 190
           W +VVIDD LPT    LVF  S   NEFW+ALLEKAYAKL G YEAL G +  + + DFT
Sbjct: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200

Query: 191 GTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLK 250
           G +AET   +     E  E  Y++   L K   +G L+ C I++ +  E E  T +GL+K
Sbjct: 201 GGVAETFQTK-----EAPENFYEI---LEKALKRGSLLGCFIDTRSAAESEARTPFGLIK 252

Query: 251 GHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDR 310
           GH Y++T I ++         F  +++ ++R+RNP G+ EW+G WS+ S EW+ +  +++
Sbjct: 253 GHAYSVTGIDQVS--------FRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQ 304

Query: 311 KNLGLVMSDDGEFWMSLEDFCRNFHKLNVCR----NVNNPIFGRKELESVLGCWTVDDDP 366
           K L     DDGEFWM+ +DF  +F K+ +C      +      + E+    G W      
Sbjct: 305 KRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRG--- 361

Query: 367 LMNRSGGCYNNRDTFLQNPQYIFTVPEDGH-----KVIMSLQQKDLRTYRRMGRPDNYII 421
             + +GGC N  DTF  NPQ   ++ E          +++L QKD R  +R G  +   I
Sbjct: 362 --STAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFG-ANVLTI 418

Query: 422 GFELFKV-----EMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQH 476
           G+ +++       +N+ F  +H     RA + T+I+ R V     L  G Y+L+P+ F+ 
Sbjct: 419 GYAIYECPDKDEHLNKDFFRYH---ASRARSKTFINLREVSDRFKLPPGEYILIPSTFEP 475

Query: 477 GRTSEFLLRIFSEVPVQLREL----TLDMPK 503
            + ++F LRIFSE     R++     +D+P+
Sbjct: 476 HQEADFCLRIFSEKKAITRDMDGNVDIDLPE 506


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  294 bits (752), Expect = 2e-79
 Identities = 181/550 (32%), Positives = 287/550 (52%), Gaps = 60/550 (10%)

Query: 8   FKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK-----VVWKRPQDICDDPH 62
           + NQ Y+ L+ EC++   LF DP+F     +L +  L P       + WKRP +IC DP 
Sbjct: 27  YLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQ 86

Query: 63  LIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFH 122
            I+G  +   + QG LG   +++A + L + E    + +P ++  +      E YAGIFH
Sbjct: 87  FIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQ------ENYAGIFH 140

Query: 123 FRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTI 182
           F+FW +GEW EVV+DD LPT +G+L+F  S   +EFW+ALLEKAYAK+ GCYEAL G   
Sbjct: 141 FQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGAT 200

Query: 183 TDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEV 242
           T+   DFTG +AE        + EL +    LF  + K   KG L+ CSI+  +  + E 
Sbjct: 201 TEGFEDFTGGIAE--------WYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEA 252

Query: 243 ETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEW 302
            T   L+KGH Y++T   ++     L +        ++R+RNP G  EW+G W++    W
Sbjct: 253 ITFQKLVKGHAYSVTGAEEVESNGSLQK--------LIRIRNPWGEVEWTGRWNDNCPSW 304

Query: 303 QQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCR----NVNNPIFGRKELESVLG 358
             +   +R+ L     +DGEFWMS  DF R++ +L +C      + +  + + +L  + G
Sbjct: 305 NTIDPEERERL-TRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDG 363

Query: 359 CWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPED---------GHKVIMSLQQKDLRT 409
            W        + +GGC N  +TF  NPQY+  + E+         G   ++ L QK  R 
Sbjct: 364 NWRRG-----STAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRR 418

Query: 410 YRRMGRPDNYIIGFELFKV--EMNRKFRLH---HLYIQERA--GTSTYIDTRTVFLSKYL 462
            R+MG  D + IGF +++V  E++ +  +H   + ++  RA   + T+I+ R V     L
Sbjct: 419 QRKMGE-DMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKL 477

Query: 463 KKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLR------ELTLDMPKMSCWNLARGYPKV 516
             G Y+LVP+ F+  +  +F +R+FSE     +      E  L+   +S  ++  G+ ++
Sbjct: 478 PPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRL 537

Query: 517 VTQITVHSAE 526
             Q+    AE
Sbjct: 538 FAQLAGEDAE 547


>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score =  293 bits (749), Expect = 4e-79
 Identities = 185/553 (33%), Positives = 281/553 (50%), Gaps = 95/553 (17%)

Query: 4   PLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHL 63
           P+   K + +++L ++C++   L+ DP F P+  SLFY++  P + VWKRP +IC++P  
Sbjct: 52  PIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRF 111

Query: 64  IVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHF 123
           I+   +   + QG LG    ++A +CL + +    + IP+      D    E YAGIFHF
Sbjct: 112 IIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHF 165

Query: 124 RFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTIT 183
           +FW +GEW +VVIDD LPT N  LVF+ S   NEFW+ALLEKAYAKL G YEAL G   T
Sbjct: 166 QFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTT 225

Query: 184 DIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIE---------S 234
           + + DFTG +AE  +++     +   + YK+   + K   +G L+ CSI+         S
Sbjct: 226 EAMEDFTGGVAEFFEIR-----DAPSDMYKI---MKKAIERGSLMGCSIDDGTNMTYGTS 277

Query: 235 PN---------------------------------------QEEQEVETDWGLLKGHTYT 255
           P+                                         + E     GL++GH Y+
Sbjct: 278 PSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYS 337

Query: 256 MTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGL 315
           +T + ++         F  EKV +VRLRNP G+ EW+G WS+  ++W  +   ++  L  
Sbjct: 338 VTGLDEV--------PFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQH 389

Query: 316 VMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVD-DDPLMNR---S 371
            +++DGEFWMS EDF  +F KL +C    + +   K     L  WTV  ++    R   +
Sbjct: 390 QVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDK-----LQTWTVSVNEGRWVRGCSA 444

Query: 372 GGCYNNRDTFLQNPQYIFTV------PEDGHKV---IMSLQQKDLRTYRRMGRPDNYIIG 422
           GGC N  DTF  NPQY   +      P+D   +   +++L QK+ R  R++G    + IG
Sbjct: 445 GGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG-ASLFTIG 503

Query: 423 FELFKVEMNRKFRLHH------LYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQH 476
           F +++V         H      LY   +A + TYI+ R V     L    YV+VP+ ++ 
Sbjct: 504 FAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEP 563

Query: 477 GRTSEFLLRIFSE 489
            +  EF+LR+FSE
Sbjct: 564 HQEGEFILRVFSE 576


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score =  293 bits (749), Expect = 4e-79
 Identities = 185/553 (33%), Positives = 281/553 (50%), Gaps = 95/553 (17%)

Query: 4   PLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHL 63
           P+   K + +++L ++C++   L+ DP F P+  SLFY++  P + VWKRP +IC++P  
Sbjct: 52  PIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRF 111

Query: 64  IVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHF 123
           I+   +   + QG LG    ++A +CL + +    + IP+      D    E YAGIFHF
Sbjct: 112 IIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQSFIENYAGIFHF 165

Query: 124 RFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTIT 183
           +FW +GEW +VVIDD LPT N  LVF+ S   NEFW+ALLEKAYAKL G YEAL G   T
Sbjct: 166 QFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTT 225

Query: 184 DIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIE---------S 234
           + + DFTG +AE  +++     +   + YK+   + K   +G L+ CSI+         S
Sbjct: 226 EAMEDFTGGVAEFFEIR-----DAPSDMYKI---MKKAIERGSLMGCSIDDGTNMTYGTS 277

Query: 235 PN---------------------------------------QEEQEVETDWGLLKGHTYT 255
           P+                                         + E     GL++GH Y+
Sbjct: 278 PSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYS 337

Query: 256 MTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGL 315
           +T + ++         F  EKV +VRLRNP G+ EW+G WS+  ++W  +   ++  L  
Sbjct: 338 VTGLDEV--------PFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQH 389

Query: 316 VMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVD-DDPLMNR---S 371
            +++DGEFWMS EDF  +F KL +C    + +   K     L  WTV  ++    R   +
Sbjct: 390 QVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDK-----LQTWTVSVNEGRWVRGCSA 444

Query: 372 GGCYNNRDTFLQNPQYIFTV------PEDGHKV---IMSLQQKDLRTYRRMGRPDNYIIG 422
           GGC N  DTF  NPQY   +      P+D   +   +++L QK+ R  R++G    + IG
Sbjct: 445 GGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLG-ASLFTIG 503

Query: 423 FELFKVEMNRKFRLHH------LYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQH 476
           F +++V         H      LY   +A + TYI+ R V     L    YV+VP+ ++ 
Sbjct: 504 FAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEP 563

Query: 477 GRTSEFLLRIFSE 489
            +  EF+LR+FSE
Sbjct: 564 HQEGEFILRVFSE 576


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  290 bits (743), Expect = 2e-78
 Identities = 185/518 (35%), Positives = 270/518 (52%), Gaps = 58/518 (11%)

Query: 8   FKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK-----VVWKRPQDICDDPH 62
           +  Q ++ L+Q+C+    LF DP F     +L Y  L PG      ++WKRP ++C  P 
Sbjct: 27  YLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQ 86

Query: 63  LIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFH 122
            IVG  +   + QG LG   +++A + L + E    + +P  ++ +      E YAGIFH
Sbjct: 87  FIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQ------ENYAGIFH 140

Query: 123 FRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTI 182
           F+FW +GEW EVVIDD LPT NG L+F  S   NEFW+ALLEKAYAKL GCYEAL G + 
Sbjct: 141 FQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGST 200

Query: 183 TDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEV 242
            +   DFTG ++E  D++K            L+  + K    G L+ CSI+  +  E E 
Sbjct: 201 VEGFEDFTGGISEFYDLKK--------PPANLYQIIRKALCAGSLLGCSIDVSSAAEAEA 252

Query: 243 ETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEW 302
            T   L+K H Y++T + ++         F      ++RLRNP G  EWSG WS+ + EW
Sbjct: 253 ITSQKLVKSHAYSVTGVEEVN--------FQGHPEKLIRLRNPWGEVEWSGAWSDDAPEW 304

Query: 303 QQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELES---VL-- 357
             +    ++ L   + +DGEFWMSL DF R F +L +C N++      +E+     VL  
Sbjct: 305 NHIDPRRKEELDKKV-EDGEFWMSLSDFVRQFSRLEIC-NLSPDSLSSEEVHKWNLVLFN 362

Query: 358 GCWTVDDDPLMNRSGGCYNNRDTFLQNPQY---IFTVPEDGHK--------VIMSLQQKD 406
           G WT       + +GGC N   T+  NPQ+   +  V ED  +        V++ L QK+
Sbjct: 363 GHWTRG-----STAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKN 417

Query: 407 LRTYRRMGRPDNYIIGFELFKV--EMNRKFRLH-----HLYIQERAGTSTYIDTRTVFLS 459
            R  +R+G+     IG+ +++V  E+      H      L  Q  A TSTY++ R V   
Sbjct: 418 RRWRKRIGQ-GMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGR 476

Query: 460 KYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLREL 497
             L  G Y++VP+ F+  +  EF LR+FSE   Q  E+
Sbjct: 477 ARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEI 514


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  270 bits (690), Expect = 3e-72
 Identities = 171/512 (33%), Positives = 260/512 (50%), Gaps = 62/512 (12%)

Query: 8   FKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK-----VVWKRPQDICDDPH 62
           +  Q Y++L+  C++   LF D  F P   SL Y  L P       + WKRP ++  +P 
Sbjct: 37  YLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQ 96

Query: 63  LIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFH 122
            IV   +   + QG LG   +++A + L + ++   + +P+ +  +        YAGIFH
Sbjct: 97  FIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQ------NGYAGIFH 150

Query: 123 FRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTI 182
           F+ W FGEW +VV+DDLLP  +G LVF  S   NEFW+ALLEKAYAK+ G YEAL G + 
Sbjct: 151 FQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGST 210

Query: 183 TDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEV 242
           ++   DFTG + E  +++K            L+  + K   +G L+ CSI+  +  + E 
Sbjct: 211 SEGFEDFTGGVTEWYELRKA--------PSDLYQIILKALERGSLLGCSIDISSVLDMEA 262

Query: 243 ETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEW 302
            T   L+KGH Y++T  +++         +  + V ++R+RNP G  EW+G WS+ S EW
Sbjct: 263 ITFKKLVKGHAYSVTGAKQVN--------YRGQVVSLIRMRNPWGEVEWTGAWSDSSSEW 314

Query: 303 QQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGR--KELESVL--G 358
             +   +R  L + M +DGEFWMS  DF R F +L +C    + +  R  ++  + L  G
Sbjct: 315 NNVDPYERDQLRVKM-EDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEG 373

Query: 359 CWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVP-----------EDGHKVIMSLQQKDL 407
            W        + +GGC N   TF  NPQ+   +            E G   +++L QK  
Sbjct: 374 TWRRG-----STAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHR 428

Query: 408 RTYRRMGRPDNYIIGFELFK----------VEMNRKFRLHHLYIQERAGTSTYIDTRTVF 457
           R  RR GR D   IGF +++          V + R F L +     RA +  +I+ R V 
Sbjct: 429 RRERRFGR-DMETIGFAVYEVPPELVGQPAVHLKRDFFLAN---ASRARSEQFINLREVS 484

Query: 458 LSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSE 489
               L  G YV+VP+ F+  +  +F+LR FSE
Sbjct: 485 TRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSE 516


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  268 bits (685), Expect = 1e-71
 Identities = 172/511 (33%), Positives = 266/511 (52%), Gaps = 59/511 (11%)

Query: 8   FKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK-----VVWKRPQDICDDPH 62
           F NQ ++EL+  C++   LF DP F  E  SL +  L P       + W+RP+DI ++P 
Sbjct: 61  FGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPL 120

Query: 63  LIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFH 122
            I+  IS   + QG LG   +++A   L        + +P  +  +      + YAGIFH
Sbjct: 121 FIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFK------KNYAGIFH 174

Query: 123 FRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTI 182
           F+ W FG+W  VV+DD LPT N  LVF  ST  +EFW+ALLEKAYAKL G YEAL G + 
Sbjct: 175 FQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGST 234

Query: 183 TDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEV 242
            + + DFTG +A++  +Q+            L   L K   +  L+ CSIE  +  E E 
Sbjct: 235 MEGLEDFTGGVAQSFQLQR--------PPQNLLRLLRKAVERSSLMGCSIEVTSDSELES 286

Query: 243 ETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEW 302
            TD  L++GH Y++T ++ +         +  +   ++R+RNP GR EW+G WS+ + EW
Sbjct: 287 MTDKMLVRGHAYSVTGLQDVH--------YRGKMETLIRVRNPWGRIEWNGAWSDSAREW 338

Query: 303 QQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKE----LESVLG 358
           +++ ASD +   L  ++DGEFWMS +DF  NF  L +C    + + G  +         G
Sbjct: 339 EEV-ASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEG 397

Query: 359 CWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPE--------DGHKVI----MSLQQKD 406
            W        + +GGC N+  TF  NPQ+  ++PE        +G+ V+    ++L QK+
Sbjct: 398 SWRRG-----SSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKN 452

Query: 407 LRTYRRMGRPDNYIIGFELFKV--------EMNRKFRLHHLYIQERAGTSTYIDTRTVFL 458
            R  R+ G      IGF L+ V        +++ K      Y Q+   +  + ++R V  
Sbjct: 453 WRHARQQG-AQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKY-QDHGFSEIFTNSREVSS 510

Query: 459 SKYLKKGNYVLVPTMFQHGRTSEFLLRIFSE 489
              L  G Y+++P+ F+  R ++FLLR+F+E
Sbjct: 511 QLRLPPGEYIIIPSTFEPHRDADFLLRVFTE 541


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  264 bits (674), Expect = 2e-70
 Identities = 163/497 (32%), Positives = 260/497 (52%), Gaps = 55/497 (11%)

Query: 56  DICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTE 115
           +IC DP  I+G  +   + QG LG   +++A + L + E    + +P ++  +      E
Sbjct: 2   EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQ------E 55

Query: 116 KYAGIFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYE 175
            YAGIFHF+FW +GEW EVV+DD LPT +G+L+F  S   +EFW+ALLEKAYAK+ GCYE
Sbjct: 56  NYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYE 115

Query: 176 ALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESP 235
           AL G   T+   DFTG +AE        + EL +    LF  + K   KG L+ CSI+  
Sbjct: 116 ALSGGATTEGFEDFTGGIAE--------WYELKKPPPNLFKIIQKALQKGSLLGCSIDIT 167

Query: 236 NQEEQEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPW 295
           +  + E  T   L+KGH Y++T   ++     L +        ++R+RNP G  EW+G W
Sbjct: 168 SAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQK--------LIRIRNPWGEVEWTGRW 219

Query: 296 SEISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCR----NVNNPIFGRK 351
           ++    W  +   +R+ L     +DGEFWMS  DF R++ +L +C      + +  + + 
Sbjct: 220 NDNCPSWNTIDPEERERL-TRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKW 278

Query: 352 ELESVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPED---------GHKVIMSL 402
           +L  + G W        + +GGC N  +TF  NPQY+  + E+         G   ++ L
Sbjct: 279 KLTKMDGNWRRG-----STAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGL 333

Query: 403 QQKDLRTYRRMGRPDNYIIGFELFKV--EMNRKFRLH---HLYIQERA--GTSTYIDTRT 455
            QK  R  R+MG  D + IGF +++V  E++ +  +H   + ++  RA   + T+I+ R 
Sbjct: 334 IQKHRRRQRKMGE-DMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLRE 392

Query: 456 VFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLR------ELTLDMPKMSCWNL 509
           V     L  G Y+LVP+ F+  +  +F +R+FSE     +      E  L+   +S  ++
Sbjct: 393 VLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDI 452

Query: 510 ARGYPKVVTQITVHSAE 526
             G+ ++  Q+    AE
Sbjct: 453 DDGFRRLFAQLAGEDAE 469


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score =  258 bits (659), Expect = 1e-68
 Identities = 169/511 (33%), Positives = 261/511 (51%), Gaps = 75/511 (14%)

Query: 11  QKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIVGNISN 70
           Q +++++QEC++   LF D  F   N SLFY+       VWKRP +I  +P  I+G  + 
Sbjct: 27  QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATR 86

Query: 71  HQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGE 130
             + QG LG   +++A + L + +    + IP  ++Q + P     YAGIFHF+FW   E
Sbjct: 87  TDICQGELGDCWLLAAIASLTLNQKALARVIP--QDQSFGPG----YAGIFHFQFWQHSE 140

Query: 131 WTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFT 190
           W +VVIDD LPT    LVF  S   NEFW+ALLEKAYAKL G YEAL G +  + + DFT
Sbjct: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200

Query: 191 GTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLK 250
           G +AET   +     E  E  Y++   L K   +G L+ C I++ +  E E  T +GL+K
Sbjct: 201 GGVAETFQTK-----EAPENFYEI---LEKALKRGSLLGCFIDTRSAAESEARTPFGLIK 252

Query: 251 GHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDR 310
           GH Y++T I ++         F  +++ ++R+RNP G+ EW+G WS            DR
Sbjct: 253 GHAYSVTGIDQVS--------FRGQRIELIRIRNPWGQVEWNGSWS------------DR 292

Query: 311 KNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPI----FGRKELESVLGCWTVDDDP 366
                         M+ +DF  +F K+ +C    + +      + E+    G W      
Sbjct: 293 --------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRG--- 335

Query: 367 LMNRSGGCYNNRDTFLQNPQYIFTVPEDGH-----KVIMSLQQKDLRTYRRMGRPDNYII 421
             + +GGC N  DTF  NPQ   ++ E          +++L QKD R  +R G  +   I
Sbjct: 336 --STAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGA-NVLTI 392

Query: 422 GFELFKV-----EMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQH 476
           G+ +++       +N+ F  +H     RA + T+I+ R V     L  G Y+L+P+ F+ 
Sbjct: 393 GYAIYECPDKDEHLNKDFFRYHA---SRARSKTFINLREVSDRFKLPPGEYILIPSTFEP 449

Query: 477 GRTSEFLLRIFSEVPVQLREL----TLDMPK 503
            + ++F LRIFSE     R++     +D+P+
Sbjct: 450 HQEADFCLRIFSEKKAITRDMDGNVDIDLPE 480


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score =  251 bits (640), Expect = 2e-66
 Identities = 166/505 (32%), Positives = 250/505 (49%), Gaps = 95/505 (18%)

Query: 52  KRPQDICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDP 111
           ++  +IC++P  I+   +   + QG LG    ++A +CL + +    + IP+      D 
Sbjct: 13  QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPH------DQ 66

Query: 112 QKTEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLL 171
              E YAGIFHF+FW +GEW +VVIDD LPT N  LVF+ S   NEFW+ALLEKAYAKL 
Sbjct: 67  SFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLH 126

Query: 172 GCYEALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCS 231
           G YEAL G   T+ + DFTG +AE  +++     +   + YK+   + K   +G L+ CS
Sbjct: 127 GSYEALKGGNTTEAMEDFTGGVAEFFEIR-----DAPSDMYKI---MKKAIERGSLMGCS 178

Query: 232 IE---------SPN---------------------------------------QEEQEVE 243
           I+         SP+                                         + E  
Sbjct: 179 IDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETR 238

Query: 244 TDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQ 303
              GL++GH Y++T + ++         F  EKV +VRLRNP G+ EW+G WS+  ++W 
Sbjct: 239 MACGLVRGHAYSVTGLDEV--------PFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWS 290

Query: 304 QLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVD 363
            +   ++  L   +++DGEFWMS EDF  +F KL +C    + +   K     L  WTV 
Sbjct: 291 FVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDK-----LQTWTVS 345

Query: 364 -DDPLMNR---SGGCYNNRDTFLQNPQYIFTV------PEDGHKV---IMSLQQKDLRTY 410
            ++    R   +GGC N  DTF  NPQY   +      P+D   +   +++L QK+ R  
Sbjct: 346 VNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKD 405

Query: 411 RRMGRPDNYIIGFELFKVEMNRKFRLHH------LYIQERAGTSTYIDTRTVFLSKYLKK 464
           R++G    + IGF +++V         H      LY   +A + TYI+ R V     L  
Sbjct: 406 RKLG-ASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPP 464

Query: 465 GNYVLVPTMFQHGRTSEFLLRIFSE 489
             YV+VP+ ++  +  EF+LR+FSE
Sbjct: 465 SEYVIVPSTYEPHQEGEFILRVFSE 489


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  229 bits (585), Expect = 5e-60
 Identities = 168/498 (33%), Positives = 255/498 (51%), Gaps = 53/498 (10%)

Query: 11  QKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLL---PGKVVWKRPQDICDDPHLIVGN 67
           Q ++ L  EC+++  LF D +F     S+    LL   P ++ WKRP ++  +P      
Sbjct: 28  QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFAK 87

Query: 68  ISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWH 127
                L QG +G    ++A   LA+ +   ++ +P ++        TEKYAGIF F FWH
Sbjct: 88  AKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSF------TEKYAGIFRFWFWH 141

Query: 128 FGEWTEVVIDDLLPTIN-GDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDII 186
           +G W  VVIDD LP    G LVF  ST  N FW ALLEKAYAKL G YE L    +++ +
Sbjct: 142 YGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEAL 201

Query: 187 VDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDW 246
           VDFTG +  T++        L E    L+  L +      LI C   S    E+ +E   
Sbjct: 202 VDFTGGVTMTIN--------LAEAHGNLWDILIEATYNRTLIGCQTHS---GEKILEN-- 248

Query: 247 GLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLT 306
           GL++GH YT+T IRK+    R          Y+V+LRNP G+ EW G WS+ S +W+ L+
Sbjct: 249 GLVEGHAYTLTGIRKVTCKHR--------PEYLVKLRNPWGKVEWKGDWSDSSSKWELLS 300

Query: 307 ASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVDDDP 366
             + K L L   +DGEFWM+L+DF  +F  L +C+ +   +  ++  +     +T+ +  
Sbjct: 301 PKE-KILLLRKDNDGEFWMTLQDFKTHFVLLVICK-LTPGLLSQEAAQK--WTYTMREGR 356

Query: 367 LMNRS---GGCYNNRDTFLQNPQYIFTV--PEDGHK------VIMSLQQKDLRTYRRMGR 415
              RS   G     +DTF +NPQ++ +V  PE+G +      V++SL QK     R+  R
Sbjct: 357 WEKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRK--R 414

Query: 416 PDNYIIGFELFKVEM--NRKFRLHHLYIQERAGTS---TYIDTRTVFLSKYLKKGNYVLV 470
                IGF L+++    + + RL   + Q     S    ++  + V     L+ G Y++V
Sbjct: 415 KPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIV 474

Query: 471 PTMFQHGRTSEFLLRIFS 488
           P + +  + SEF+LR+FS
Sbjct: 475 PCILEAHQKSEFVLRVFS 492


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  229 bits (585), Expect = 5e-60
 Identities = 168/532 (31%), Positives = 248/532 (46%), Gaps = 80/532 (15%)

Query: 5   LKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK-----VVWKRPQDICD 59
           L+LF+ Q Y+ ++  C+    LF DP F    D+L Y++L P       V W RP + C 
Sbjct: 24  LQLFRGQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCA 83

Query: 60  DPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAG 119
           +P  I  ++S   + QG LG+   ++A + L +      + +P  ++ +        YAG
Sbjct: 84  EPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQ------HGYAG 137

Query: 120 IFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDG 179
           +FHF+ W FG W +VV+DD LP   G L+F  S   NEFW  LLEKAYAKL G YE + G
Sbjct: 138 VFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRG 197

Query: 180 LTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEE 239
             + +  VDFTG + E + ++        +    LF  L     K  L+  +  S   + 
Sbjct: 198 GHMNEAFVDFTGGVGEVLYLR--------QNSMGLFSALRHALAKESLVGATALS---DR 246

Query: 240 QEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEIS 299
            E  T+ GL+KGH Y++T   K+ LG          KV ++RLRNP G  EW+G WS+  
Sbjct: 247 GEYRTEEGLVKGHAYSITGTHKVFLG--------FTKVRLLRLRNPWGCVEWTGAWSDSC 298

Query: 300 EEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNV-----NNPIFGRKELE 354
             W  L    R  L LV  +DGEFWM L DF  +F  + +C         +P  G   + 
Sbjct: 299 PRWDTLPTECRDAL-LVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVH 357

Query: 355 SVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHK----------------- 397
           +  G W    +     SGG   N +TF  NPQ+  T+ E   +                 
Sbjct: 358 TFQGRWVRGFN-----SGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGA 412

Query: 398 -------------VIMSLQQKDLRTYRRMGRPDNYI-IGFELFKVE-----MNRKFRLHH 438
                        V++SL Q++ R  R  G    Y+ +GF +F++      +    R H 
Sbjct: 413 RGPARGGRTPKCTVLLSLIQRNRRRLRAKGL--TYLTVGFHVFQIPEELLGLWDSPRSHA 470

Query: 439 LYIQ-ERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSE 489
           L  +  RA  S     R V     L+ G+Y++VP+    G  ++F LR+FSE
Sbjct: 471 LLPRLLRADRSPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSE 522


>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score =  180 bits (456), Expect = 4e-45
 Identities = 155/511 (30%), Positives = 222/511 (43%), Gaps = 72/511 (14%)

Query: 26  LFCDPTFLPENDSLFYNRLLP-----GKVVWKRPQDICDDPHLIVGNISNHQLTQGRLGH 80
           LF D  F   + SLF +   P       + W+RPQ+IC  P L   +    Q+ QG LG 
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 81  KPMVSAFSCLAVQES-HWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDL 139
              + A  C A+Q+S H    +    +  W  Q+   Y G F  R W FG W EV  DD 
Sbjct: 73  CWFLCA--CAALQKSRHLLDQVIPPGQPSWADQE---YRGSFTCRIWQFGRWVEVTTDDR 127

Query: 140 LPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDM 199
           LP + G L FS     + FW  LLEK YAK+ G YE L    + D +VD TG LAE  ++
Sbjct: 128 LPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNL 187

Query: 200 Q-----KGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTY 254
           +      G+       +++   +L        LI C + SP    +E      L + H +
Sbjct: 188 KGVAGSGGQQDRPGRWEHRTCRQLLH-LKDQCLISCCVLSPRAGARE------LGEFHAF 240

Query: 255 TMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLG 314
            ++D+R+++ G+      + + + ++R++NP GR+ W G W E  E W Q+ A+    L 
Sbjct: 241 IVSDLRELQ-GQ------AGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASEL- 292

Query: 315 LVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVL------------GCWTV 362
           L    +GEFW+  E+F R F +L     V  P+     L+S+             G W  
Sbjct: 293 LSQLQEGEFWVEEEEFLREFDEL----TVGYPVTEAGHLQSLYTERLLCHTRALPGAWVK 348

Query: 363 DDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYI-- 420
                   +GGC NN   F  NP++   V E     I  LQ+  L      GR    +  
Sbjct: 349 GQS-----AGGCRNN-SGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGD 402

Query: 421 -----------------IGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLK 463
                            +G  L+KVE  R      L +   AGT+ +   R V L   L 
Sbjct: 403 SHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELS 462

Query: 464 KGNYVLVPTMFQHGRTSEFLLRIFSEVPVQL 494
            G Y+ VP+ F      EFLLR+FS   V L
Sbjct: 463 PGYYLAVPSTFLKDAPGEFLLRVFSTGRVSL 493


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  177 bits (448), Expect = 3e-44
 Identities = 162/512 (31%), Positives = 232/512 (45%), Gaps = 63/512 (12%)

Query: 8   FKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGK----VVWKRPQDICDDP-H 62
           FK+Q +  L+  C+   R F D TF P  DS    +LL  K    V+WKRPQD+   P H
Sbjct: 16  FKDQDFTTLRDHCLSMGRTFKDETF-PAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPH 74

Query: 63  LIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFH 122
            I+ +IS   + QG       ++A   L     +  K +     Q +  Q    YAGIF 
Sbjct: 75  FILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL---MVQSFSHQ----YAGIFR 127

Query: 123 FRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMN-EFWNALLEKAYAKLLGCYEALDGLT 181
           FRFW  G+W EVVIDD LP      +F      N EFW  LLEKAYAKLLG Y  L    
Sbjct: 128 FRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGF 187

Query: 182 ITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGG--LICCSIESPNQEE 239
           + D +VD TG +   + +      +LV        +  KT TK G  + C +   P    
Sbjct: 188 LEDALVDLTGGVITNIHLHSSP-VDLV--------KAVKTATKAGSLITCATPSGPTDTA 238

Query: 240 QEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNP--LGRQEWSGPWSE 297
           Q +E   GL+  H YT+T   +I+      E+ S        L NP   G  EW G WS+
Sbjct: 239 QAMEN--GLVSLHAYTVTGAEQIQYRRGWEEIIS--------LWNPWGWGEAEWRGRWSD 288

Query: 298 ISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPI---FGRKELE 354
            S+EW++ T   RK+      +DGEFWMS +DF + F  + +C  +  PI    G    E
Sbjct: 289 GSQEWEE-TCDPRKSQLHKKREDGEFWMSCQDFQQKFIAMFICSEI--PITLDHGNTLHE 345

Query: 355 SVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTV--PEDGHKVI----MSLQQKDLR 408
                       L N +GG  N       + Q+ F+V  P +G  V+    +++   +L+
Sbjct: 346 GWSQIMFRKQVILGNTAGGPRN-------DAQFNFSVQEPMEGTNVVVCVTVAVTPSNLK 398

Query: 409 TYRRMGRPDNYII--GFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGN 466
                   D  +I  G + F+ +    F       +    +S     R   ++ +L  GN
Sbjct: 399 AEDAKFPLDFQVILAGSQRFREKFPPVF---FSSFRNTVQSSNNKFRRNFTMTYHLSPGN 455

Query: 467 YVLVPTMFQHGRTSEFLLRIFSEVPVQLRELT 498
           YV+V       +++EFLLRIF ++P   R L+
Sbjct: 456 YVVVAQ--TRRKSAEFLLRIFLKMPDSDRHLS 485


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  155 bits (391), Expect = 1e-37
 Identities = 127/413 (30%), Positives = 185/413 (44%), Gaps = 53/413 (12%)

Query: 26  LFCDPTFLPENDSLFYNRLLP-----GKVVWKRPQDICDDPHLIVGNISNHQLTQGRLGH 80
           LF D  F   + SLF +   P       + W+RPQ+IC  P L   +    Q+ QG LG 
Sbjct: 13  LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 81  KPMVSAFSCLAVQES-HWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDL 139
              + A  C A+Q+S H    +    +  W  Q+   Y G F  R W FG W EV  DD 
Sbjct: 73  CWFLCA--CAALQKSRHLLDQVIPPGQPSWADQE---YRGSFTCRIWQFGRWVEVTTDDR 127

Query: 140 LPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDM 199
           LP + G L FS     + FW  LLEK YAK+ G YE L    + D +VD TG LAE  ++
Sbjct: 128 LPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNL 187

Query: 200 Q-----KGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTY 254
           +      G+       +++   +L        LI C + SP    +E      L + H +
Sbjct: 188 KGVAGSGGQQDRPGRWEHRTCRQLLH-LKDQCLISCCVLSPRAGARE------LGEFHAF 240

Query: 255 TMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLG 314
            ++D+R+++ G+      + + + ++R++NP GR+ W G W E  E W Q+ A+    L 
Sbjct: 241 IVSDLRELQ-GQ------AGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASEL- 292

Query: 315 LVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVL------------GCWTV 362
           L    +GEFW+  E+F R F +L     V  P+     L+S+             G W  
Sbjct: 293 LSQLQEGEFWVEEEEFLREFDEL----TVGYPVTEAGHLQSLYTERLLCHTRALPGAWVK 348

Query: 363 DDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGR 415
                   +GGC NN   F  NP++   V E     I  LQ+  L      GR
Sbjct: 349 GQS-----AGGCRNN-SGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGR 395


>gi|7656959 calpain 7 [Homo sapiens]
          Length = 813

 Score =  102 bits (253), Expect = 1e-21
 Identities = 112/461 (24%), Positives = 196/461 (42%), Gaps = 71/461 (15%)

Query: 51  WKRPQDICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTI------PNH 104
           W RP+D+ ++P +I   +S+  + Q  +     V++ +  A  E  + K +      P +
Sbjct: 261 WVRPEDLTNNPTMIY-TVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319

Query: 105 KEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDLLPTIN-GDLVFSFSTSMNEFWNALL 163
           K+ E +     KY    H      G   +V+IDD LP  + G+L+ S+S + +E W +L+
Sbjct: 320 KDGEPEYNPCGKYMVKLHLN----GVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLI 375

Query: 164 EKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFT 223
           EKAY K++G Y+     +  D+    TG + E + M     T   +  +++   LY+ F 
Sbjct: 376 EKAYMKVMGGYDFPGSNSNIDLHA-LTGWIPERIAMHSDSQTFSKDNSFRM---LYQRFH 431

Query: 224 KGG-LICCSIESPNQEEQEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRL 282
           KG  LI  S     + E E    WGL+  H Y + DIR+ + G R ++           L
Sbjct: 432 KGDVLITASTGMMTEAEGE---KWGLVPTHAYAVLDIREFK-GLRFIQ-----------L 476

Query: 283 RNPLGRQEWSGPWSE-----ISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKL 337
           +NP     W G +SE      + E Q+    D +    +  D+G FW+S +D C+ +  +
Sbjct: 477 KNPWSHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKI--DNGIFWISWDDLCQYYDVI 534

Query: 338 NVCRNVNNPIFGRKELESVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTV--PEDG 395
            +  + N  +F  KE   +   W     P+         +  +   NPQY   V  P+ G
Sbjct: 535 YL--SWNPGLF--KESTCIHSTWDAKQGPV--------KDAYSLANNPQYKLEVQCPQGG 582

Query: 396 HKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRT 455
             V + L        R +   D++    E   + +   ++     +   A    YID   
Sbjct: 583 AAVWVLLS-------RHITDKDDFANNREFITMVV---YKTDGKKVYYPADPPPYIDGIR 632

Query: 456 VFLSKYLKK--------GNYVLVPTMFQHGRTSEFLLRIFS 488
           +    YL K          + LV + ++   T  + +R++S
Sbjct: 633 INSPHYLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYS 673



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 31/130 (23%), Positives = 56/130 (43%), Gaps = 21/130 (16%)

Query: 371 SGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEM 430
           +GGC N ++T   NP Y F + + G  +I             +  P  Y +GFE+  V  
Sbjct: 701 AGGCGNFQETHKNNPIYQFHIEKTGPLLI------------ELRGPRQYSVGFEVVTVST 748

Query: 431 NRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLK---KGNYVLVPTMFQHGRTSEFLLRIF 487
                 H  ++++ +G     D R  F    L+    G + ++P+ F   +   F L   
Sbjct: 749 LGDPGPHG-FLRKSSG-----DYRCGFCYLELENIPSGIFNIIPSTFLPKQEGPFFLDFN 802

Query: 488 SEVPVQLREL 497
           S +P+++ +L
Sbjct: 803 SIIPIKITQL 812


>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 86/335 (25%), Positives = 141/335 (42%), Gaps = 37/335 (11%)

Query: 20  CIKDSRLFCDPTFLPENDSLFY---NRLLPGKVVWKRPQDI-CD------DPHLIVGNIS 69
           C +++  F D +F P  +S+ +   + +      W RPQ+I C           +   + 
Sbjct: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540

Query: 70  NHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFG 129
              + QG LG+   +SA + LA +     + +           ++    G +  R    G
Sbjct: 541 PSDILQGLLGNCWFLSALAVLAERPDLVERVMVT---------RSLCAEGAYQVRLCKDG 591

Query: 130 EWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDF 189
            WT V++DD+LP      +        + W AL+EKA AKL G Y AL      + +   
Sbjct: 592 TWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATL 651

Query: 190 TGTLAETVDMQKGRYTELVE--EKYKLFGELYKTFTKGGLICCSIESPNQE-EQEVETDW 246
           TG   E++ +Q        E  +   ++ ++  +   G L+  S    N + +       
Sbjct: 652 TGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESL 711

Query: 247 GLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLT 306
           GL   H Y++ D+R ++ G RL           +RLRNP GR  W+G W   S+EW    
Sbjct: 712 GLRPRHAYSILDVRDVQ-GTRL-----------LRLRNPWGRFSWNGSW---SDEWPHWP 756

Query: 307 ASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCR 341
              R  L    S +G FWM   DF R F  +++C+
Sbjct: 757 GHLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICK 791


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 20/51 (39%), Positives = 30/51 (58%)

Query: 439 LYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSE 489
           LY   +A + TYI+ R V     L    YV+VP+ ++  +  EF+LR+FSE
Sbjct: 14  LYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSE 64


>gi|13186314 calpain 10 isoform g [Homo sapiens]
          Length = 139

 Score = 38.5 bits (88), Expect = 0.019
 Identities = 26/75 (34%), Positives = 36/75 (48%), Gaps = 7/75 (9%)

Query: 26 LFCDPTFLPENDSLFYNRLLP-----GKVVWKRPQDICDDPHLIVGNISNHQLTQGRLGH 80
          LF D  F   + SLF +   P       + W+RPQ+IC  P L   +    Q+ QG LG 
Sbjct: 13 LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72

Query: 81 KPMVSAFSCLAVQES 95
             + A  C A+Q+S
Sbjct: 73 CWFLCA--CAALQKS 85


>gi|7662394 RAB11 family interacting protein 2 (class I) [Homo
           sapiens]
          Length = 512

 Score = 37.4 bits (85), Expect = 0.043
 Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 8/89 (8%)

Query: 519 QITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFY-------- 570
           Q+TV  A+DL+ K  + T + Y +I+ GKE+  + V + T+  ++  +A F         
Sbjct: 16  QVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQG 75

Query: 571 RRTTDIPIIVQVWNSRKFCDQFLGQVTLD 599
                I  ++ +  S    D+FLGQV ++
Sbjct: 76  SPEKYILFLIVMHRSLVGLDKFLGQVAIN 104


>gi|122937514 unc-13 homolog C [Homo sapiens]
          Length = 2214

 Score = 37.0 bits (84), Expect = 0.056
 Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 12/92 (13%)

Query: 520  ITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPII 579
            ITV SA+ L+ K    + +PY+ ++ GK + R+      ++ ++D +  F    +   I 
Sbjct: 1224 ITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIK 1283

Query: 580  VQVWNS------------RKFCDQFLGQVTLD 599
            V+VW+             +K  D FLGQ  ++
Sbjct: 1284 VRVWDEDDDIKSRVKQHFKKESDDFLGQTIVE 1315


>gi|168823435 hypothetical protein LOC79747 [Homo sapiens]
          Length = 1667

 Score = 36.2 bits (82), Expect = 0.096
 Identities = 35/133 (26%), Positives = 62/133 (46%), Gaps = 11/133 (8%)

Query: 119 GIFHFRFWHFGEWTEVVIDDLLP-TINGDLVFSFSTSMNEFWNALLEKAYAKLLGC-YEA 176
           G +  + +  G W ++ IDD LP   + +L+   +T   E W  LL KA  KL       
Sbjct: 195 GKYVVKLYWMGCWRKITIDDFLPFDEDNNLLLPATTYEFELWPMLLSKAIIKLANIDIHV 254

Query: 177 LDGLTITD--IIVDFTGTLAETVDMQKG---RYTELVEE---KYKLFGELYKTFTKGGLI 228
            D   + +  +I   TG L E + +  G   +  EL++E   ++KL  E   + +K  ++
Sbjct: 255 ADRRELGEFTVIHALTGWLPEVISLHPGYMDKVWELLKEILPEFKLSDEA-SSESKIAVL 313

Query: 229 CCSIESPNQEEQE 241
              ++ P +E +E
Sbjct: 314 DSKLKEPGKEGKE 326


>gi|122937247 unc-13 homolog A [Homo sapiens]
          Length = 1791

 Score = 32.3 bits (72), Expect = 1.4
 Identities = 21/92 (22%), Positives = 42/92 (45%), Gaps = 12/92 (13%)

Query: 520 ITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPII 579
           ITV  A+ L+ K    + +PY+ ++ GK + R+      ++ +++    F    +   I 
Sbjct: 768 ITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIK 827

Query: 580 VQVWNS------------RKFCDQFLGQVTLD 599
           V+VW+             ++  D FLGQ  ++
Sbjct: 828 VRVWDEDDDIKSRVKQRFKRESDDFLGQTIIE 859


>gi|16757970 niban protein isoform 2 [Homo sapiens]
          Length = 928

 Score = 30.8 bits (68), Expect = 4.0
 Identities = 20/77 (25%), Positives = 34/77 (44%), Gaps = 14/77 (18%)

Query: 105 KEQEWDPQKTEKYAGIFHFRFWHFGEW-----------TEVVIDDLLPTINGDLVFSFST 153
           K+  ++ Q   +    F     H+G W           + +V+++LLPT+  DL+     
Sbjct: 204 KQMTFEAQAFLEAVQFFRQEKGHYGSWEMITGDEIQILSNLVMEELLPTLQTDLLPKMKG 263

Query: 154 SMNE---FWNALLEKAY 167
             N+    W  LLE+AY
Sbjct: 264 KKNDRKRTWLGLLEEAY 280


>gi|221316654 neuropeptide FF receptor 2 isoform 1 [Homo sapiens]
          Length = 522

 Score = 30.4 bits (67), Expect = 5.2
 Identities = 20/60 (33%), Positives = 25/60 (41%)

Query: 270 EVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGLVMSDDGEFWMSLED 329
           +V SA      R R  L  Q+  GP    S EW + +A DR+ LGL        W    D
Sbjct: 18  DVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRRLGLSRQTAKSSWSRSRD 77


>gi|7657455 pescadillo homolog 1, containing BRCT domain [Homo
           sapiens]
          Length = 588

 Score = 30.0 bits (66), Expect = 6.8
 Identities = 18/59 (30%), Positives = 32/59 (54%), Gaps = 2/59 (3%)

Query: 235 PNQEEQEVETDWGLLKGHT-YTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWS 292
           P++ + + + + G     T Y + DIR + L E +V  F   KV++ +LR   G+ EW+
Sbjct: 45  PHEPKHKKKVNKGSTAARTFYLIKDIRFL-LHEPIVNKFREYKVFVRKLRKAYGKSEWN 102


>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
          Length = 1591

 Score = 30.0 bits (66), Expect = 6.8
 Identities = 20/92 (21%), Positives = 42/92 (45%), Gaps = 12/92 (13%)

Query: 520 ITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPII 579
           ITV  A+ L+ K    + +PY+ ++  K + R+      ++ +++ +  F    +   I 
Sbjct: 604 ITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIK 663

Query: 580 VQVWNS------------RKFCDQFLGQVTLD 599
           V+VW+             ++  D FLGQ  ++
Sbjct: 664 VRVWDEDDDIKSRVKQRLKRESDDFLGQTIIE 695


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,187,823
Number of Sequences: 37866
Number of extensions: 1130908
Number of successful extensions: 2229
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2094
Number of HSP's gapped (non-prelim): 41
length of query: 641
length of database: 18,247,518
effective HSP length: 109
effective length of query: 532
effective length of database: 14,120,124
effective search space: 7511905968
effective search space used: 7511905968
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.