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Search of human proteins with 40806170
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40806170 spastin isoform 2 [Homo sapiens]
(584 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40806170 spastin isoform 2 [Homo sapiens] 1151 0.0
gi|11875211 spastin isoform 1 [Homo sapiens] 1134 0.0
gi|31742536 fidgetin-like 1 [Homo sapiens] 336 3e-92
gi|112789543 fidgetin-like 1 [Homo sapiens] 336 3e-92
gi|64084766 fidgetin [Homo sapiens] 244 2e-64
gi|5901990 katanin p60 subunit A 1 [Homo sapiens] 244 2e-64
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens] 240 3e-63
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens] 240 3e-63
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens] 236 3e-62
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens] 227 3e-59
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens] 215 8e-56
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens] 192 7e-49
gi|116292174 fidgetin-like 2 [Homo sapiens] 180 4e-45
gi|157671927 spermatogenesis associated 5 [Homo sapiens] 178 1e-44
gi|6005942 valosin-containing protein [Homo sapiens] 158 1e-38
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens] 149 5e-36
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens] 149 5e-36
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens] 145 1e-34
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens] 144 2e-34
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens] 142 7e-34
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens] 142 1e-33
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens] 139 9e-33
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens] 137 2e-32
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ... 136 5e-32
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi... 136 5e-32
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens] 136 5e-32
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens] 135 1e-31
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens] 132 7e-31
gi|4505725 peroxin1 [Homo sapiens] 132 7e-31
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens] 131 2e-30
>gi|40806170 spastin isoform 2 [Homo sapiens]
Length = 584
Score = 1151 bits (2977), Expect = 0.0
Identities = 584/584 (100%), Positives = 584/584 (100%)
Query: 1 MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG 60
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
Sbjct: 1 MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG 60
Query: 61 FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH 120
FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
Sbjct: 61 FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH 120
Query: 121 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK 180
KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
Sbjct: 121 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK 180
Query: 181 MMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGL 240
MMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGL
Sbjct: 181 MMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGL 240
Query: 241 SMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEI 300
SMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEI
Sbjct: 241 SMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEI 300
Query: 301 VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLA 360
VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLA
Sbjct: 301 VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLA 360
Query: 361 KAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERRE 420
KAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERRE
Sbjct: 361 KAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERRE 420
Query: 421 GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEE 480
GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEE
Sbjct: 421 GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEE 480
Query: 481 TRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNM 540
TRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNM
Sbjct: 481 TRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNM 540
Query: 541 SASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDTTV 584
SASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDTTV
Sbjct: 541 SASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDTTV 584
>gi|11875211 spastin isoform 1 [Homo sapiens]
Length = 616
Score = 1134 bits (2934), Expect = 0.0
Identities = 584/616 (94%), Positives = 584/616 (94%), Gaps = 32/616 (5%)
Query: 1 MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG 60
MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
Sbjct: 1 MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG 60
Query: 61 FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH 120
FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
Sbjct: 61 FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH 120
Query: 121 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK 180
KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
Sbjct: 121 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK 180
Query: 181 MMTNLVMAKDRLQLL--------------------------------ESGAVPKRKDPLT 208
MMTNLVMAKDRLQLL ESGAVPKRKDPLT
Sbjct: 181 MMTNLVMAKDRLQLLEKMQPVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLT 240
Query: 209 HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK 268
HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK
Sbjct: 241 HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK 300
Query: 269 PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL 328
PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL
Sbjct: 301 PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL 360
Query: 329 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 388
PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE
Sbjct: 361 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 420
Query: 389 KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV 448
KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV
Sbjct: 421 KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV 480
Query: 449 LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM 508
LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM
Sbjct: 481 LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM 540
Query: 509 TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT 568
TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT
Sbjct: 541 TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT 600
Query: 569 LEAYIRWNKDFGDTTV 584
LEAYIRWNKDFGDTTV
Sbjct: 601 LEAYIRWNKDFGDTTV 616
>gi|31742536 fidgetin-like 1 [Homo sapiens]
Length = 674
Score = 336 bits (862), Expect = 3e-92
Identities = 174/397 (43%), Positives = 254/397 (63%), Gaps = 17/397 (4%)
Query: 199 AVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSG------- 251
A K +D +SLP KT + + P + S GVK+ G
Sbjct: 277 ACSKTEDNGPKEDSSLPTFKTAKEQLWVDQQKKYHQPQRASGSSYGGVKKSLGASRSRGI 336
Query: 252 ------PAPTTHKGTPKTNRTNKP--STPTTATRKKKDLKNFRNVDSNLANLIMNEIVDN 303
P P G KP + PT + +N++ + LIMNEI+D+
Sbjct: 337 LGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDE--RLKNLEPKMIELIMNEIMDH 394
Query: 304 GTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAV 363
G V ++DIAG + AK ++EIV+ P LRP++FTGLR P +G+LLFGPPG GKT++ K +
Sbjct: 395 GPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCI 454
Query: 364 AAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEH 423
A++S ATFF+ISA+SLTSK+VGEGEK+VRALFAVAR QP++IFIDE+DSLL +R +GEH
Sbjct: 455 ASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEH 514
Query: 424 DASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRL 483
++SRR+KTEFL++ DG ++ +DR+LV+GATNRPQE+DEA RR +KR+Y+ LP R
Sbjct: 515 ESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARK 574
Query: 484 LLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSAS 543
++ NL+ K+ L+++E+ Q+ + +D +SG+D+T L ++A+LGPIR L+ + ++
Sbjct: 575 QIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPD 634
Query: 544 EMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 580
++R I DF + + ++ SVSP+ LE Y WNK FG
Sbjct: 635 QVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFG 671
>gi|112789543 fidgetin-like 1 [Homo sapiens]
Length = 674
Score = 336 bits (862), Expect = 3e-92
Identities = 174/397 (43%), Positives = 254/397 (63%), Gaps = 17/397 (4%)
Query: 199 AVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSG------- 251
A K +D +SLP KT + + P + S GVK+ G
Sbjct: 277 ACSKTEDNGPKEDSSLPTFKTAKEQLWVDQQKKYHQPQRASGSSYGGVKKSLGASRSRGI 336
Query: 252 ------PAPTTHKGTPKTNRTNKP--STPTTATRKKKDLKNFRNVDSNLANLIMNEIVDN 303
P P G KP + PT + +N++ + LIMNEI+D+
Sbjct: 337 LGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDE--RLKNLEPKMIELIMNEIMDH 394
Query: 304 GTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAV 363
G V ++DIAG + AK ++EIV+ P LRP++FTGLR P +G+LLFGPPG GKT++ K +
Sbjct: 395 GPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCI 454
Query: 364 AAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEH 423
A++S ATFF+ISA+SLTSK+VGEGEK+VRALFAVAR QP++IFIDE+DSLL +R +GEH
Sbjct: 455 ASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEH 514
Query: 424 DASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRL 483
++SRR+KTEFL++ DG ++ +DR+LV+GATNRPQE+DEA RR +KR+Y+ LP R
Sbjct: 515 ESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARK 574
Query: 484 LLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSAS 543
++ NL+ K+ L+++E+ Q+ + +D +SG+D+T L ++A+LGPIR L+ + ++
Sbjct: 575 QIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPD 634
Query: 544 EMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 580
++R I DF + + ++ SVSP+ LE Y WNK FG
Sbjct: 635 QVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFG 671
>gi|64084766 fidgetin [Homo sapiens]
Length = 759
Score = 244 bits (623), Expect = 2e-64
Identities = 168/581 (28%), Positives = 273/581 (46%), Gaps = 53/581 (9%)
Query: 13 SGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVGFALLRLVAFHLG 72
S G P PP PPPP L P NL +SYP
Sbjct: 216 SSGLLQPPPPPPPPPALVPGYNGTS-----------NLSSYSYPS--------------- 249
Query: 73 LLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEA---ERVRVFHKQAFEYISI 129
+ + + S G AP P SA P+ +P V + Q I
Sbjct: 250 ------ASYPPQTAVGSGYSPGGAPPPPSAYLPSGIPAPTPLPPTTVPGYTYQGHGLTPI 303
Query: 130 ALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAKMMTNLVMAK 189
A + A ++ +Y G +++ GQ + +M N +
Sbjct: 304 APSALTNSSASSLKRKA-FYMAGQGDMDSSYGNYSYGQQRSTQSP---MYRMPDNSISNT 359
Query: 190 DRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQG 249
+R + A L S + S+ S PSYS G +
Sbjct: 360 NRGNGFDRSA---ETSSLAFKPTKQLMSSEQQRKFSSQSSRALTPPSYSTAKNSLGSRSS 416
Query: 250 ------SGPAPTTHKGTPKTNRTNKPSTP----TTATRKKKDLKNFRNVDSNLANLIMNE 299
+ P + H + ++ P T++ D + +N D++L +L+ NE
Sbjct: 417 ESFGKYTSPVMSEHGDEHRQLLSHPMQGPGLRAATSSNHSVD-EQLKNTDTHLIDLVTNE 475
Query: 300 IVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTML 359
I+ G V ++DIAG DL K ++E V+ P LR + F+GL A R +LLFGP G GKT+L
Sbjct: 476 IITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLL 535
Query: 360 AKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERR 419
+ +A++ ATFF I+ + L +K++GE EK++ A F VAR QPS+IF+ ++D LL +
Sbjct: 536 GRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQV 595
Query: 420 EGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNE 479
EH R++TEFL++ D V ++ +D+++V+ AT++P+E+DE++ R F+KR+ + LP+
Sbjct: 596 NEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMKRLLIPLPDS 655
Query: 480 ETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKN 539
R ++ LL + L KE A L + T+G+SG D+ L ++A +GP+ + +
Sbjct: 656 TARHQIIVQLLSQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAVVGPLHAMPATDLSA 715
Query: 540 MSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 580
+ S++R + DF + KI+ S+S + L+ Y+ WNK FG
Sbjct: 716 IMPSQLRPVTYQDFENAFCKIQPSISQKELDMYVEWNKMFG 756
>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
Length = 491
Score = 244 bits (623), Expect = 2e-64
Identities = 140/328 (42%), Positives = 203/328 (61%), Gaps = 14/328 (4%)
Query: 265 RTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQE 324
R K +P T + + + D +L + +I+ V++DDIA AK+ L+E
Sbjct: 164 REEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKE 223
Query: 325 IVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYV 384
V+LP PE F G+R P +G+L+ GPPG GKT+LAKAVA E TFFN+S+++LTSKY
Sbjct: 224 AVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYR 283
Query: 385 GEGEKLVRALFAVARELQPSIIFIDEVDSLLCERR--EGEHDASRRLKTEFLIEFDGV-- 440
GE EKLVR LF +AR P+ IFIDE+DS +C RR EH+ASRR+K E L++ DGV
Sbjct: 284 GESEKLVRLLFEMARFYSPATIFIDEIDS-ICSRRGTSEEHEASRRVKAELLVQMDGVGG 342
Query: 441 QSAGDD---RVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPL 497
S DD V+V+ ATN P ++DEA+ RR KR+Y+ LP+ + R LL+ + ++
Sbjct: 343 TSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLR-ISLRELELA 401
Query: 498 TQKELAQLARMTDGYSGSDLTALAKDAALGPIRE----LKPEQVKNMSASEMR-NIRLSD 552
+LA +A +GYSG+D+T + +DA+L +R L PE+++N+S EM + D
Sbjct: 402 DDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMED 461
Query: 553 FTESLKKIKRSVSPQTLEAYIRWNKDFG 580
F +LKK+ +SVS +E Y +W +FG
Sbjct: 462 FEMALKKVSKSVSAADIERYEKWIFEFG 489
>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 240 bits (612), Expect = 3e-63
Identities = 141/305 (46%), Positives = 196/305 (64%), Gaps = 16/305 (5%)
Query: 289 DSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLL 348
D +L + +IV ++ +DDIA + AK+ L+E V+LP P+ F G+R P +G+L+
Sbjct: 187 DKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLM 246
Query: 349 FGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFI 408
GPPG GKTMLAKAVA E TFFN+S+++LTSKY GE EKLVR LF +AR P+ IFI
Sbjct: 247 VGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFI 306
Query: 409 DEVDSLLCERR--EGEHDASRRLKTEFLIEFDGVQSA--GDD---RVLVMGATNRPQELD 461
DE+DS +C RR EH+ASRR+K+E LI+ DGV A DD V+V+ ATN P ++D
Sbjct: 307 DEIDS-ICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365
Query: 462 EAVLRRFIKRVYVSLPNEETRLLLLK-NLLCKQGSPLTQKELAQLARMTDGYSGSDLTAL 520
EA+ RR KR+Y+ LP + R LLK NL + P Q L +A +GYSG+D+T +
Sbjct: 366 EALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQ--LEDIAEKIEGYSGADITNV 423
Query: 521 AKDAALGPIRE----LKPEQVKNMSASEMR-NIRLSDFTESLKKIKRSVSPQTLEAYIRW 575
+DA+L +R L PE+++ +S E++ + DF +LKKI +SVS LE Y +W
Sbjct: 424 CRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKW 483
Query: 576 NKDFG 580
+FG
Sbjct: 484 MVEFG 488
>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 240 bits (612), Expect = 3e-63
Identities = 141/305 (46%), Positives = 196/305 (64%), Gaps = 16/305 (5%)
Query: 289 DSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLL 348
D +L + +IV ++ +DDIA + AK+ L+E V+LP P+ F G+R P +G+L+
Sbjct: 187 DKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLM 246
Query: 349 FGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFI 408
GPPG GKTMLAKAVA E TFFN+S+++LTSKY GE EKLVR LF +AR P+ IFI
Sbjct: 247 VGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFI 306
Query: 409 DEVDSLLCERR--EGEHDASRRLKTEFLIEFDGVQSA--GDD---RVLVMGATNRPQELD 461
DE+DS +C RR EH+ASRR+K+E LI+ DGV A DD V+V+ ATN P ++D
Sbjct: 307 DEIDS-ICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365
Query: 462 EAVLRRFIKRVYVSLPNEETRLLLLK-NLLCKQGSPLTQKELAQLARMTDGYSGSDLTAL 520
EA+ RR KR+Y+ LP + R LLK NL + P Q L +A +GYSG+D+T +
Sbjct: 366 EALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQ--LEDIAEKIEGYSGADITNV 423
Query: 521 AKDAALGPIRE----LKPEQVKNMSASEMR-NIRLSDFTESLKKIKRSVSPQTLEAYIRW 575
+DA+L +R L PE+++ +S E++ + DF +LKKI +SVS LE Y +W
Sbjct: 424 CRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKW 483
Query: 576 NKDFG 580
+FG
Sbjct: 484 MVEFG 488
>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
Length = 444
Score = 236 bits (603), Expect = 3e-62
Identities = 134/293 (45%), Positives = 184/293 (62%), Gaps = 13/293 (4%)
Query: 262 KTNRTNKPSTPTTATRKKKDLKNFRNVDS----NLANLIMNEIVDNGTAVKFDDIAGQDL 317
K + K P+ A K D D L N + IV VK+ D+AG +
Sbjct: 82 KAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEG 141
Query: 318 AKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESN-ATFFNISA 376
AK+AL+E VILP P LFTG R P RG+LLFGPPG GK+ LAKAVA E+N +TFF+IS+
Sbjct: 142 AKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISS 201
Query: 377 ASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIE 436
+ L SK++GE EKLV+ LF +ARE +PSIIFIDE+DSL R E E +A+RR+KTEFL++
Sbjct: 202 SDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQ 261
Query: 437 FDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSP 496
GV +D +LV+GATN P LD A+ RRF KR+Y+ LP R + K L +
Sbjct: 262 MQGV-GVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHLGTTQNS 320
Query: 497 LTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIR 549
LT+ + +L R TDGYSG+D++ + +DA + P+R+++ SA+ + +R
Sbjct: 321 LTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQ-------SATHFKKVR 366
>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
Length = 437
Score = 227 bits (578), Expect = 3e-59
Identities = 119/243 (48%), Positives = 170/243 (69%), Gaps = 2/243 (0%)
Query: 292 LANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGP 351
L +M +V ++++D+AG + AK+AL+E VILP P LFTG R P RG+LLFGP
Sbjct: 109 LQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGP 168
Query: 352 PGNGKTMLAKAVAAESN-ATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDE 410
PG GK+ LAKAVA E+N +TFF++S++ L SK++GE EKLV+ LF +AR+ +PSIIFIDE
Sbjct: 169 PGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDE 228
Query: 411 VDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIK 470
VDSL R E E +A+RR+KTEFL++ GV + +D LV+GATN P LD A+ RRF K
Sbjct: 229 VDSLCGSRNENESEAARRIKTEFLVQMQGVGN-NNDGTLVLGATNIPWVLDSAIRRRFEK 287
Query: 471 RVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR 530
R+Y+ LP E R + + L LT + +LAR T+GYSG+D++ + +D+ + P+R
Sbjct: 288 RIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVR 347
Query: 531 ELK 533
+++
Sbjct: 348 KVQ 350
>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
Length = 466
Score = 215 bits (548), Expect = 8e-56
Identities = 129/325 (39%), Positives = 199/325 (61%), Gaps = 19/325 (5%)
Query: 272 PTTATRKKKDLKNFRNVDSN---LANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL 328
P + R K L F ++S LA ++ +I + +K++DI G D AKQ ++E V+
Sbjct: 141 PDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVY 200
Query: 329 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 388
P P+LFTG+ +P +GLLL+GPPG GKT+LAKAVA E TFFNISA+++ SK+ G+ E
Sbjct: 201 PIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSE 260
Query: 389 KLVRALFAVARELQPSIIFIDEVDSLLCER---REGEHDASRRLKTEFLIEFDGVQSAGD 445
KLVR LF +AR PS IF+DE++S++ +R GEH+ S R+KTE L++ DG+ + +
Sbjct: 261 KLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGL-ARSE 319
Query: 446 DRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPL-----TQK 500
D V V+ A+N P ELD A+LRR KR+ V LP+ E R ++ + L T+
Sbjct: 320 DLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTEL 379
Query: 501 ELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMS-ASEMRNIRL-----SDFT 554
E + L++ T+GYSGSD+ + ++AA+ P+R++ + S +S++ I+L +DF
Sbjct: 380 EYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFL 439
Query: 555 ESLKKIKRSVSPQTLEAYIRWNKDF 579
+ L K S + + Y W ++F
Sbjct: 440 DVLTHTKPS-AKNLAQRYSDWQREF 463
>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
Length = 361
Score = 192 bits (488), Expect = 7e-49
Identities = 106/260 (40%), Positives = 166/260 (63%), Gaps = 4/260 (1%)
Query: 307 VKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA--PARGLLLFGPPGNGKTMLAKAVA 364
V + DIAG D L++ VILP + LF R P +G+LL+GPPG GKT++AKA A
Sbjct: 88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATA 147
Query: 365 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 424
E+ F N+ ++LT K+ GE +KL A+F++A +LQPSIIFIDE+DS L R +H+
Sbjct: 148 KEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHE 207
Query: 425 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLL 484
A+ +K +F+ +DG+ + +V+VMGATNRPQ+LD A++RR R +++ P + R
Sbjct: 208 ATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREA 267
Query: 485 LLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRE-LKPEQVKNMSAS 543
+LK L+ K + +L ++A+ TDG+SGSDL + +DAAL +RE + ++
Sbjct: 268 ILK-LILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDED 326
Query: 544 EMRNIRLSDFTESLKKIKRS 563
E+R ++ D +++K+K+S
Sbjct: 327 EIRPVQQQDLHRAIEKMKKS 346
>gi|116292174 fidgetin-like 2 [Homo sapiens]
Length = 653
Score = 180 bits (456), Expect = 4e-45
Identities = 107/295 (36%), Positives = 161/295 (54%), Gaps = 12/295 (4%)
Query: 286 RNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARG 345
+ VD L+ +++VD G V++ D+AGQ K AL+E ++ P LRP + G P R
Sbjct: 368 KGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRT 427
Query: 346 LLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSI 405
+LLFGP G GK +L + +A + AT + A+L + EG +L++A FA AR PS+
Sbjct: 428 VLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSV 487
Query: 406 IFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVL 465
+ I E+++LL R +G A L+ L DG AG D VLV+G T+RP LDEA
Sbjct: 488 LLISELEALLPARDDGA-AAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATR 546
Query: 466 RRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAA 525
RRF R YV+LP+ R +L+ L +QG L+++ELA L + T G+SG +L L + AA
Sbjct: 547 RRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAA 606
Query: 526 LGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 580
G R + D +L K+ S + L++++ W+K +G
Sbjct: 607 AGA-----------GLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYG 650
Score = 34.7 bits (78), Expect = 0.25
Identities = 18/44 (40%), Positives = 19/44 (43%)
Query: 2 NSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESP 45
N P G + GA P P PP P L P PA P P P P
Sbjct: 204 NYPAGGYAAQPGYGALPPPPGPPPAPYLTPGLPAPTPLPAPAPP 247
>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
Length = 893
Score = 178 bits (452), Expect = 1e-44
Identities = 114/287 (39%), Positives = 166/287 (57%), Gaps = 14/287 (4%)
Query: 284 NFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPA 343
NF +D N ++ DN V +D I G +A++EI+ LP +PELF PA
Sbjct: 333 NFTEIDKN------SKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPA 386
Query: 344 -RGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQ 402
RG+LL+GPPG GKTM+A+AVA E A I+ + SK+ GE E +R +FA A
Sbjct: 387 PRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRH 446
Query: 403 PSIIFIDEVDSLLCERREG-EHDASRRLKTEFLIEFDGVQS-AGDDRVLVMGATNRPQEL 460
PSIIFIDE+D+ LC +REG +++ +R+ L DG+ S + +VLV+GATNRP L
Sbjct: 447 PSIIFIDELDA-LCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHAL 505
Query: 461 DEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLT 518
D A+ R RF K + + +PN + RL +L+ LL + LT+ EL QLA GY G+DL
Sbjct: 506 DAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLK 565
Query: 519 ALAKDAALGPIREL--KPEQVKNMSASEMRNIRLSDFTESLKKIKRS 563
L +A L +R + K + ++ + + I L DF +++ I+ S
Sbjct: 566 VLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPS 612
Score = 153 bits (387), Expect = 4e-37
Identities = 107/307 (34%), Positives = 165/307 (53%), Gaps = 24/307 (7%)
Query: 279 KKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTG 338
K LK+F +++ M EI + V + DI G + K L++ V P PE F
Sbjct: 596 KITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIR 655
Query: 339 LRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAV 397
+ P +G+LL+GPPG KTM+AKA+A ES F I L +KYVGE E+ VR F
Sbjct: 656 MGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRK 715
Query: 398 ARELQPSIIFIDEVDSLLCERRE--GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATN 455
AR + PSIIF DE+D+L ER G + + R+ + L E DG++ D V ++ ATN
Sbjct: 716 ARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKD--VTILAATN 773
Query: 456 RPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK-ELAQLARMTDGY 512
RP +D+A++R R + +YV LP+ TR + K L P++ + +L +L TD Y
Sbjct: 774 RPDRIDKALMRPGRIDRIIYVPLPDAATRREIFK--LQFHSMPVSNEVDLDELILQTDAY 831
Query: 513 SGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAY 572
SG+++ A+ ++AAL + E + I FT++L +V+P+ E+
Sbjct: 832 SGAEIVAVCREAALLALEE----------DIQANLIMKRHFTQALS----TVTPRIPESL 877
Query: 573 IRWNKDF 579
R+ +D+
Sbjct: 878 RRFYEDY 884
>gi|6005942 valosin-containing protein [Homo sapiens]
Length = 806
Score = 158 bits (399), Expect = 1e-38
Identities = 107/296 (36%), Positives = 164/296 (55%), Gaps = 24/296 (8%)
Query: 297 MNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGL-RAPARGLLLFGPPGNG 355
+ E V V ++DI G + K+ LQE+V P P+ F P++G+L +GPPG G
Sbjct: 464 LRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCG 523
Query: 356 KTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLL 415
KT+LAKA+A E A F +I L + + GE E VR +F AR+ P ++F DE+DS+
Sbjct: 524 KTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIA 583
Query: 416 CERREGEHD---ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIK 470
R D A+ R+ + L E DG+ + V ++GATNRP +D A+LR R +
Sbjct: 584 KARGGNIGDGGGAADRVINQILTEMDGMST--KKNVFIIGATNRPDIIDPAILRPGRLDQ 641
Query: 471 RVYVSLPNEETRLLLLKNLLCKQGSPLTQK-ELAQLARMTDGYSGSDLTALAKDAALGPI 529
+Y+ LP+E++R+ +LK L K SP+ + +L LA+MT+G+SG+DLT + + A I
Sbjct: 642 LIYIPLPDEKSRVAILKANLRK--SPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAI 699
Query: 530 RELKPEQVK-------NMSASEMR------NIRLSDFTESLKKIKRSVSPQTLEAY 572
RE +++ N SA E+ IR F E+++ +RSVS + Y
Sbjct: 700 RESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKY 755
Score = 146 bits (368), Expect = 6e-35
Identities = 97/271 (35%), Positives = 150/271 (55%), Gaps = 11/271 (4%)
Query: 307 VKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAA 365
V +DDI G ++E+V LP P LF + P RG+LL+GPPG GKT++A+AVA
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260
Query: 366 ESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDA 425
E+ A FF I+ + SK GE E +R F A + P+IIFIDE+D++ +R + +
Sbjct: 261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEV 320
Query: 426 SRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRL 483
RR+ ++ L DG++ V+VM ATNRP +D A+ R RF + V + +P+ RL
Sbjct: 321 ERRIVSQLLTLMDGLKQRA--HVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRL 378
Query: 484 LLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR---ELKPEQVKNM 540
+L+ + K +L Q+A T G+ G+DL AL +AAL IR +L + + +
Sbjct: 379 EILQ-IHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETI 437
Query: 541 SASEMRN--IRLSDFTESLKKIKRSVSPQTL 569
A M + + + DF +L + S +T+
Sbjct: 438 DAEVMNSLAVTMDDFRWALSQSNPSALRETV 468
>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
Length = 750
Score = 149 bits (377), Expect = 5e-36
Identities = 100/278 (35%), Positives = 152/278 (54%), Gaps = 16/278 (5%)
Query: 307 VKFDDIAGQDLAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 364
V + DI + ++ L ++ P P+ F GL PA G+LL GPPG GKT+LAKAVA
Sbjct: 472 VTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPA-GVLLAGPPGCGKTLLAKAVA 530
Query: 365 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 424
ES F ++ L + YVGE E+ VR +F A+ P +IF DEVD+L R + E
Sbjct: 531 NESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG 590
Query: 425 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETR 482
AS R+ + L E DG+++ +V +M ATNRP +D A+LR R K ++V LP R
Sbjct: 591 ASVRVVNQLLTEMDGLEAR--QQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADR 648
Query: 483 LLLLKNLLCKQGSPLTQKELAQLA----RMTDGYSGSDLTALAKDAALGPIRELKPEQVK 538
L +LK + P ++ A D Y+G+DL+AL ++A++ +R+ E +
Sbjct: 649 LAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ---EMAR 705
Query: 539 NMSASEMRNIRLS--DFTESLKKIKRSVSPQTLEAYIR 574
S +E +++S F E+ KK++ S+S + Y R
Sbjct: 706 QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 743
Score = 142 bits (359), Expect = 7e-34
Identities = 97/282 (34%), Positives = 154/282 (54%), Gaps = 18/282 (6%)
Query: 277 RKKKDLKNFRNVDSNLANLIMNEIVDNG-----TAVKFDDIAGQDLAKQALQEIVILPSL 331
RKK+DL+ VD + ++ + G + VKF+D+ G D+ + + +++I
Sbjct: 124 RKKEDLQE---VDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLI-HMR 179
Query: 332 RPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 390
PE++ L P RG+LL GPPG GKT+LA A+A E + ++A + S GE E+
Sbjct: 180 HPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQK 239
Query: 391 VRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQS-AGDDRVL 449
+R LF A P IIFIDE+D++ +R D RR+ + L D + + A RVL
Sbjct: 240 LRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVL 299
Query: 450 VMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLAR 507
V+GATNRP LD A+ R RF + + + +P+E +R +L+ L K P + LA
Sbjct: 300 VIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLP-QAFDFCHLAH 358
Query: 508 MTDGYSGSDLTALAKDAALGPIR----ELKPEQVKNMSASEM 545
+T G+ G+DL AL ++AA+ + +L+ +Q KN ++
Sbjct: 359 LTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDL 400
>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
Length = 856
Score = 149 bits (377), Expect = 5e-36
Identities = 100/278 (35%), Positives = 152/278 (54%), Gaps = 16/278 (5%)
Query: 307 VKFDDIAGQDLAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 364
V + DI + ++ L ++ P P+ F GL PA G+LL GPPG GKT+LAKAVA
Sbjct: 578 VTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPA-GVLLAGPPGCGKTLLAKAVA 636
Query: 365 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 424
ES F ++ L + YVGE E+ VR +F A+ P +IF DEVD+L R + E
Sbjct: 637 NESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG 696
Query: 425 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETR 482
AS R+ + L E DG+++ +V +M ATNRP +D A+LR R K ++V LP R
Sbjct: 697 ASVRVVNQLLTEMDGLEAR--QQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADR 754
Query: 483 LLLLKNLLCKQGSPLTQKELAQLA----RMTDGYSGSDLTALAKDAALGPIRELKPEQVK 538
L +LK + P ++ A D Y+G+DL+AL ++A++ +R+ E +
Sbjct: 755 LAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ---EMAR 811
Query: 539 NMSASEMRNIRLS--DFTESLKKIKRSVSPQTLEAYIR 574
S +E +++S F E+ KK++ S+S + Y R
Sbjct: 812 QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 849
Score = 142 bits (359), Expect = 7e-34
Identities = 97/282 (34%), Positives = 154/282 (54%), Gaps = 18/282 (6%)
Query: 277 RKKKDLKNFRNVDSNLANLIMNEIVDNG-----TAVKFDDIAGQDLAKQALQEIVILPSL 331
RKK+DL+ VD + ++ + G + VKF+D+ G D+ + + +++I
Sbjct: 230 RKKEDLQE---VDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLI-HMR 285
Query: 332 RPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 390
PE++ L P RG+LL GPPG GKT+LA A+A E + ++A + S GE E+
Sbjct: 286 HPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQK 345
Query: 391 VRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQS-AGDDRVL 449
+R LF A P IIFIDE+D++ +R D RR+ + L D + + A RVL
Sbjct: 346 LRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVL 405
Query: 450 VMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLAR 507
V+GATNRP LD A+ R RF + + + +P+E +R +L+ L K P + LA
Sbjct: 406 VIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLP-QAFDFCHLAH 464
Query: 508 MTDGYSGSDLTALAKDAALGPIR----ELKPEQVKNMSASEM 545
+T G+ G+DL AL ++AA+ + +L+ +Q KN ++
Sbjct: 465 LTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDL 506
>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
Length = 406
Score = 145 bits (366), Expect = 1e-34
Identities = 94/247 (38%), Positives = 147/247 (59%), Gaps = 14/247 (5%)
Query: 292 LANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLR-APARGLLLFG 350
L +L+M E V + T ++ I G D + ++E++ LP PELF L A +G+LL+G
Sbjct: 134 LVSLMMVEKVPDST---YEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYG 190
Query: 351 PPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDE 410
PPG GKT+LA+AVA ++ TF +S + L K++GEG ++VR LF +ARE PSIIF+DE
Sbjct: 191 PPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDE 250
Query: 411 VDSLLCERREGEHDAS---RRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR- 466
+DS+ R EG +R E L + DG ++ + +V++ ATNR LD A+LR
Sbjct: 251 IDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIM--ATNRIDILDSALLRP 308
Query: 467 -RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK-ELAQLARMTDGYSGSDLTALAKDA 524
R +++ PNEE RL +LK + + LT+ L ++A + G SG+++ + +A
Sbjct: 309 GRIDRKIEFPPPNEEARLDILK--IHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEA 366
Query: 525 ALGPIRE 531
+ +RE
Sbjct: 367 GMYALRE 373
>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
Length = 403
Score = 144 bits (363), Expect = 2e-34
Identities = 86/245 (35%), Positives = 143/245 (58%), Gaps = 15/245 (6%)
Query: 295 LIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPG 353
L+ N ++ V + +I G + L+E++ LP PELF + P +G LL+GPPG
Sbjct: 132 LVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPG 191
Query: 354 NGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDS 413
GKT+LA+AVA++ + F + ++S+ KY+GE +L+R +F AR+ QP IIF+DE+D+
Sbjct: 192 TGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDA 251
Query: 414 LLCERREGEHDASRRLK---TEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RF 468
+ R A R ++ E L + DG + RV ++ ATNRP LD A+LR R
Sbjct: 252 IGGRRFSEGTSADREIQRTLMELLNQMDGFDTL--HRVKMIMATNRPDTLDPALLRPGRL 309
Query: 469 IKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK---ELAQLARMTDGYSGSDLTALAKDAA 525
+++++ LPNE+ RL +LK P+T+ + + +++DG++G+DL + +A
Sbjct: 310 DRKIHIDLPNEQARLDILK----IHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAG 365
Query: 526 LGPIR 530
+ IR
Sbjct: 366 MFAIR 370
>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
Length = 440
Score = 142 bits (359), Expect = 7e-34
Identities = 91/240 (37%), Positives = 136/240 (56%), Gaps = 15/240 (6%)
Query: 301 VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTML 359
V+ + DI G D Q ++E V LP PE + + P +G++L+GPPG GKT+L
Sbjct: 176 VEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLL 235
Query: 360 AKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERR 419
AKAVA +++ATF + + L KY+G+G KLVR LF VA E PSI+FIDE+D++ +R
Sbjct: 236 AKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRY 295
Query: 420 EGEHDASR---RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYV 474
+ R R E L + DG S GD +V++ ATNR + LD A++R R +++
Sbjct: 296 DSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIM--ATNRIETLDPALIRPGRIDRKIEF 353
Query: 475 SLPNEETRLLLLKNLLCKQGSPLTQKE---LAQLARMTDGYSGSDLTALAKDAALGPIRE 531
LP+E+T+ K + S +T + L L D SG+D+ A+ +A L +RE
Sbjct: 354 PLPDEKTK----KRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRE 409
>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
Length = 439
Score = 142 bits (357), Expect = 1e-33
Identities = 91/237 (38%), Positives = 135/237 (56%), Gaps = 11/237 (4%)
Query: 301 VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTML 359
VD ++ DI G D Q L E ++LP E F L P +G+L++GPPG GKT+L
Sbjct: 177 VDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLL 236
Query: 360 AKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERR 419
A+A AA++ ATF ++ L ++G+G KLVR FA+A+E PSIIFIDE+D++ +R
Sbjct: 237 ARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRF 296
Query: 420 EGEHDASR---RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYV 474
+ E R R E L + DG Q + +V V+ ATNR LD A+LR R +++
Sbjct: 297 DSEKAGDREVQRTMLELLNQLDGFQP--NTQVKVIAATNRVDILDPALLRSGRLDRKIEF 354
Query: 475 SLPNEETRLLLLKNLLCKQG-SPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR 530
+PNEE R +++ K SP E +LAR TD ++G+ A+ +A + +R
Sbjct: 355 PMPNEEARARIMQIHSRKMNVSPDVNYE--ELARCTDDFNGAQCKAVCVEAGMIALR 409
>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
Length = 1458
Score = 139 bits (349), Expect = 9e-33
Identities = 130/454 (28%), Positives = 205/454 (45%), Gaps = 63/454 (13%)
Query: 111 GEAERVRVFHKQAFEYISIALRIDEDEKAGQK---------EQAVEWYKKGIEELEKGIA 161
GE ER+R++ FE + + R+ K+ ++ E + E ++ +E E G
Sbjct: 212 GEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSYGIQNHHEVSTEGEEEESQE-EDGDI 270
Query: 162 VIVTGQGEQCERARRLQAKMMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVM 221
+ +GE+ +R L+ + DR Q P ++ R T+
Sbjct: 271 EVEEAEGEENDRPYNLRQRKTV------DRYQA-----------PPIVPAHQKKRENTLF 313
Query: 222 KTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKD 281
HR+P+ S + K + TT + R + S R +
Sbjct: 314 DI--------HRSPARR--SHIRRKKHAIHSSDTTSSDEERFER--RKSKSMARARNRCL 361
Query: 282 LKNFRNVDSNLANLIMNEIVDNGTA------------VKFDDIAGQDLAKQALQEIVILP 329
NFR D LA+ I+ E V G + V+FD I G AL+E+V+ P
Sbjct: 362 PMNFRAED--LASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFP 419
Query: 330 SLRPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAAESN-----ATFFNISAASLTSKY 383
L PE+F + P RG L +GPPG GKT++A+A+A E + FF A SK+
Sbjct: 420 LLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKW 479
Query: 384 VGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSA 443
VGE E+ +R LF A ++PSIIF DE+D L R + + + L DG+ +
Sbjct: 480 VGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNR 539
Query: 444 GDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKE 501
G+ ++V+GATNR +D A+ R RF + +LP+++ R +L+ L+
Sbjct: 540 GE--IVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAF 597
Query: 502 LAQLARMTDGYSGSDLTALAKDAALGPIRELKPE 535
L +LA GY G+D+ AL +AAL +R P+
Sbjct: 598 LGELAEKCVGYCGADIKALCTEAALIALRRRYPQ 631
>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
Length = 1390
Score = 137 bits (346), Expect = 2e-32
Identities = 91/268 (33%), Positives = 141/268 (52%), Gaps = 14/268 (5%)
Query: 305 TAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTMLAKAV 363
++V+FD + G AL+E+V+ P L PE+F + P RG L +GPPG GKT++A+A+
Sbjct: 421 SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL 480
Query: 364 AAESN-----ATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCER 418
A E + FF A SK+VGE E+ +R LF A +++PSIIF DE+D L R
Sbjct: 481 ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR 540
Query: 419 REGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSL 476
+ + + L DG+ S G+ ++V+GATNR +D A+ R RF + SL
Sbjct: 541 SSRQDQIHSSIVSTLLALMDGLDSRGE--IVVIGATNRLDSIDPALRRPGRFDREFLFSL 598
Query: 477 PNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQ 536
P++E R +LK L +LA GY G+D+ ++ +AAL +R P+
Sbjct: 599 PDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQI 658
Query: 537 VKNMSASEMR----NIRLSDFTESLKKI 560
++ NI DF +++K+
Sbjct: 659 YTTSEKLQLDLSSINISAKDFEVAMQKM 686
Score = 33.5 bits (75), Expect = 0.56
Identities = 37/165 (22%), Positives = 71/165 (43%), Gaps = 18/165 (10%)
Query: 346 LLLFGPPGNGK-TMLAKAVA-AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQP 403
+L+ G PG G+ + LA AV A T + + L E+ + A+ P
Sbjct: 795 ILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAP 854
Query: 404 SIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRP-----Q 458
SI+++ + LK F + S VL++ +++P +
Sbjct: 855 SIVYVPHIHVWW-------EIVGPTLKATFTTLLQNIPSFAP--VLLLATSDKPHSALPE 905
Query: 459 ELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGS--PLTQKE 501
E+ E +R + + V LP++E R ++L+ KQ + P+++K+
Sbjct: 906 EVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKK 950
>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
[Homo sapiens]
Length = 414
Score = 136 bits (343), Expect = 5e-32
Identities = 85/242 (35%), Positives = 133/242 (54%), Gaps = 9/242 (3%)
Query: 296 IMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGN 354
IM D V + DI G D+ KQ ++E V LP EL+ + P RG+L++GPPG
Sbjct: 147 IMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGC 206
Query: 355 GKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSL 414
GKTMLAKAVA + A F + + KY+GEG ++VR +F +A+E P+IIFIDE+D++
Sbjct: 207 GKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAI 266
Query: 415 LCERREGEHDASR---RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFI 469
+R + + A R R+ E L + DG + V V+ ATNR LD A+LR R
Sbjct: 267 ATKRFDAQTGADREVQRILLELLNQMDGFDQ--NVNVKVIMATNRADTLDPALLRPGRLD 324
Query: 470 KRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPI 529
+++ LP+ + L+ + K + +L D SG+D+ ++ +++ + +
Sbjct: 325 RKIEFPLPDRRQKRLIFSTITSKMNLS-EEVDLEDYVARPDKISGADINSICQESGMLAV 383
Query: 530 RE 531
RE
Sbjct: 384 RE 385
>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
sapiens]
Length = 387
Score = 136 bits (343), Expect = 5e-32
Identities = 85/242 (35%), Positives = 133/242 (54%), Gaps = 9/242 (3%)
Query: 296 IMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGN 354
IM D V + DI G D+ KQ ++E V LP EL+ + P RG+L++GPPG
Sbjct: 120 IMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGC 179
Query: 355 GKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSL 414
GKTMLAKAVA + A F + + KY+GEG ++VR +F +A+E P+IIFIDE+D++
Sbjct: 180 GKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAI 239
Query: 415 LCERREGEHDASR---RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFI 469
+R + + A R R+ E L + DG + V V+ ATNR LD A+LR R
Sbjct: 240 ATKRFDAQTGADREVQRILLELLNQMDGFDQ--NVNVKVIMATNRADTLDPALLRPGRLD 297
Query: 470 KRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPI 529
+++ LP+ + L+ + K + +L D SG+D+ ++ +++ + +
Sbjct: 298 RKIEFPLPDRRQKRLIFSTITSKMNLS-EEVDLEDYVARPDKISGADINSICQESGMLAV 356
Query: 530 RE 531
RE
Sbjct: 357 RE 358
>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
Length = 418
Score = 136 bits (343), Expect = 5e-32
Identities = 85/242 (35%), Positives = 133/242 (54%), Gaps = 9/242 (3%)
Query: 296 IMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGN 354
IM D V + DI G D+ KQ ++E V LP EL+ + P RG+L++GPPG
Sbjct: 151 IMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGC 210
Query: 355 GKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSL 414
GKTMLAKAVA + A F + + KY+GEG ++VR +F +A+E P+IIFIDE+D++
Sbjct: 211 GKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAI 270
Query: 415 LCERREGEHDASR---RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFI 469
+R + + A R R+ E L + DG + V V+ ATNR LD A+LR R
Sbjct: 271 ATKRFDAQTGADREVQRILLELLNQMDGFDQ--NVNVKVIMATNRADTLDPALLRPGRLD 328
Query: 470 KRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPI 529
+++ LP+ + L+ + K + +L D SG+D+ ++ +++ + +
Sbjct: 329 RKIEFPLPDRRQKRLIFSTITSKMNLS-EEVDLEDYVARPDKISGADINSICQESGMLAV 387
Query: 530 RE 531
RE
Sbjct: 388 RE 389
>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
Length = 980
Score = 135 bits (339), Expect = 1e-31
Identities = 100/281 (35%), Positives = 146/281 (51%), Gaps = 11/281 (3%)
Query: 306 AVKFDDIAGQDLAKQALQEIVILPSLRPELFT-GLRAPARGLLLFGPPGNGKTMLAKAVA 364
+V + D+ G K+ + E + LP PEL + GLR GLLL GPPG GKT+LAKAVA
Sbjct: 701 SVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAVA 758
Query: 365 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCER-REGEH 423
E + TF ++ L + YVG+ E+ VR +FA AR P IIF DE+DSL R R G+
Sbjct: 759 TECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDS 818
Query: 424 -DASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEE 480
R+ ++ L E DG+ S D V V+GATNRP LD A+LR RF K V+V +
Sbjct: 819 GGVMDRVVSQLLAELDGLHSTQD--VFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDR 876
Query: 481 TRLLLLKNLLCKQGSPLTQKELAQ-LARMTDGYSGSDLTALAKDAALGPIRELKPEQVKN 539
L + + + ++ L L +G+DL +L DA ++ + +
Sbjct: 877 ASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEG 936
Query: 540 MS-ASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDF 579
+ S + + D ++ +++ SVS Q L Y R + F
Sbjct: 937 LEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977
Score = 68.9 bits (167), Expect = 1e-11
Identities = 64/213 (30%), Positives = 103/213 (48%), Gaps = 14/213 (6%)
Query: 326 VILPSLRP--ELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKY 383
V+ P L+P L TG + +LL GPPG GKT + A + + +SL ++
Sbjct: 448 VLKPRLQPGGALLTGTSS----VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAES 503
Query: 384 VGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKT--EFLIEFDGVQ 441
G E ++A+F+ AR +P+++ + VD LL R+G + +R + L+ D +
Sbjct: 504 SGAVETKLQAIFSRARRCRPAVLLLTAVD-LLGRDRDGLGEDARVMAVLRHLLLNEDPLN 562
Query: 442 SAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK- 500
S ++V+ T+R Q+L V F + V +E RL +L+ L PL Q+
Sbjct: 563 SC--PPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAH--LPLGQEV 618
Query: 501 ELAQLARMTDGYSGSDLTALAKDAALGPIRELK 533
LAQLAR G+ DL AL ++ +K
Sbjct: 619 NLAQLARRCAGFVVGDLYALLTHSSRAACTRIK 651
>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
Length = 753
Score = 132 bits (333), Expect = 7e-31
Identities = 99/259 (38%), Positives = 142/259 (54%), Gaps = 20/259 (7%)
Query: 312 IAGQDLAKQALQEIVILPSLRPELFTGLR-APARGLLLFGPPGNGKTMLAKAVAAESNAT 370
+ G A +L+E++ LP P T L A RG+LL GPPG GKT L +AVA E+ A
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
Query: 371 FFNISAASLTSKYVGEGEKLVRALFAVARELQ---PSIIFIDEVDSLLCERREGEHDASR 427
+SA +L GE E+ VR +F AREL PS++F+DE+D+L +R G
Sbjct: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR--GSRAPES 319
Query: 428 RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLL 485
R+ + L DG ++GD V+V+GATNRP LD A+ R RF + V + P + R +
Sbjct: 320 RVVAQVLTLLDG--ASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEI 377
Query: 486 LKNLLCKQGSPLTQK-ELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASE 544
L+ + K P++ +L LA MT GY G+DLTAL ++AA+ + + Q N E
Sbjct: 378 LQVITSKM--PISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQ-DNPVIDE 434
Query: 545 MRNIRLSDFTESLKKIKRS 563
+ DF E+ K I+ S
Sbjct: 435 I------DFLEAFKNIQPS 447
Score = 128 bits (321), Expect = 2e-29
Identities = 98/302 (32%), Positives = 154/302 (50%), Gaps = 36/302 (11%)
Query: 307 VKFDDIAGQDLAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 364
V +++I G + K L++ + P P F GL P +G+LL+GPPG KT L +A+A
Sbjct: 461 VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQP-KGVLLYGPPGCAKTTLVRALA 519
Query: 365 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEH- 423
+ +F ++S A L S +VG+ EK++ +F AR P+I+F+DE+DS+L R +
Sbjct: 520 TSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTG 579
Query: 424 -DASRRLKTEFLIEFDGV-----------------QSAGDDRVLVMGATNRPQELDEAVL 465
D R+ + L E DGV Q + V+++ ATNRP LD A+L
Sbjct: 580 CDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALL 639
Query: 466 R--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPL-TQKELAQLARMTDGYSGSDLTALAK 522
R R K +Y+ P+ + RL +LK +C + P+ L LA T +SG+DL L
Sbjct: 640 RPGRLDKIIYIPPPDHKGRLSILK--VCTKTMPIGPDVSLENLAAETCFFSGADLRNLCT 697
Query: 523 DAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDT 582
+AAL ++E + + ++ F +SLK +K S+S + L Y K G +
Sbjct: 698 EAALLALQE---------NGLDATTVKQEHFLKSLKTVKPSLSCKDLALYENLFKKEGFS 748
Query: 583 TV 584
V
Sbjct: 749 NV 750
>gi|4505725 peroxin1 [Homo sapiens]
Length = 1283
Score = 132 bits (333), Expect = 7e-31
Identities = 83/221 (37%), Positives = 123/221 (55%), Gaps = 6/221 (2%)
Query: 309 FDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPAR-GLLLFGPPGNGKTMLAKAVAAES 367
+D I G +Q L + + LP+ PELF L R G+LL+GPPG GKT+LA +A ES
Sbjct: 839 WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898
Query: 368 NATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASR 427
F ++ L SKY+G E+ VR +F A+ +P I+F DE +S+ R +
Sbjct: 899 RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTD 958
Query: 428 RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLL 485
R+ + L + DGV+ G V V+ AT+RP +D A+LR R K VY P++ +RL +
Sbjct: 959 RVVNQLLTQLDGVE--GLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEI 1016
Query: 486 LKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAAL 526
L N+L +L +A +TD ++G+DL AL +A L
Sbjct: 1017 L-NVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQL 1056
Score = 51.6 bits (122), Expect = 2e-06
Identities = 58/213 (27%), Positives = 97/213 (45%), Gaps = 30/213 (14%)
Query: 335 LFTGLRAPARGLLLFGPPGNGKTMLAKAVAAES----NATFFNISAASLTSKYVGEGEKL 390
L GLR A LLL G G+GK+ LAKA+ E+ +A + +L K + +K
Sbjct: 586 LVAGLRNGA--LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKT 643
Query: 391 VRALFAVARELQPSIIFIDEVDSLLCERREGEHD------ASRRLK---TEFLIEFDGVQ 441
+ F+ A +QPS++ +D++D + EH+ S+RL + + EF +
Sbjct: 644 LEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMG 703
Query: 442 SAGDDRVLVMGATNRPQELDEAVL------RRFIKRVYVSLPNEETRLLLL----KNLLC 491
S ++ + AT++ Q+ +L F ++ PN+E R +L KN L
Sbjct: 704 S-----LVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLD 758
Query: 492 KQGSPLTQKELAQLARMTDGYSGSDLTALAKDA 524
+ T +L +A+ T G+ D T L A
Sbjct: 759 CDINKFTDLDLQHVAKETGGFVARDFTVLVDRA 791
>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
Length = 797
Score = 131 bits (329), Expect = 2e-30
Identities = 93/270 (34%), Positives = 143/270 (52%), Gaps = 17/270 (6%)
Query: 272 PTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIV-ILPS 330
P R + + +V A ++ +EI VKF D+AG + AK + E V L +
Sbjct: 275 PAGIGRTGRGMGGLFSVGETTAKVLKDEI-----DVKFKDVAGCEEAKLEIMEFVNFLKN 329
Query: 331 LRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 390
+ G + P +G +L GPPG GKT+LAKA A E+N F +S + +VG G
Sbjct: 330 PKQYQDLGAKIP-KGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPAR 388
Query: 391 VRALFAVARELQPSIIFIDEVDSLLCERREGE---HDASRRLKTEFLIEFDGVQSAGDDR 447
VR LFA+AR+ P I+FIDE+D++ +R G + L+E DG +
Sbjct: 389 VRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTT--TN 446
Query: 448 VLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLL--CKQGSPLTQKELA 503
V+++ TNRP LD A+LR RF +++++ P+ + R + K L K S L + +LA
Sbjct: 447 VVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLA 506
Query: 504 -QLARMTDGYSGSDLTALAKDAALGPIREL 532
+LA +T G+SG+D+ + +AAL R L
Sbjct: 507 RKLASLTPGFSGADVANVCNEAALIAARHL 536
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,761,781
Number of Sequences: 37866
Number of extensions: 1347178
Number of successful extensions: 26124
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 393
Number of HSP's successfully gapped in prelim test: 356
Number of HSP's that attempted gapping in prelim test: 16494
Number of HSP's gapped (non-prelim): 7408
length of query: 584
length of database: 18,247,518
effective HSP length: 108
effective length of query: 476
effective length of database: 14,157,990
effective search space: 6739203240
effective search space used: 6739203240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.