Search of human proteins with 24497618

Search of human proteins with 24497618

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24497618 ATPase family, AAA domain containing 2 [Homo
sapiens]
         (1390 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]    2763   0.0  
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]  1218   0.0  
gi|6005942 valosin-containing protein [Homo sapiens]                  223   8e-58
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              204   4e-52
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            188   4e-47
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             183   9e-46
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            177   6e-44
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 176   1e-43
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           174   5e-43
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 173   1e-42
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            169   1e-41
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       162   2e-39
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               160   8e-39
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               160   8e-39
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           157   5e-38
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   155   3e-37
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   155   3e-37
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   155   3e-37
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     154   6e-37
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]          149   2e-35
gi|4505725 peroxin1 [Homo sapiens]                                    148   3e-35
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     144   8e-34
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]         141   4e-33
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]            141   5e-33
gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]          138   4e-32
gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]          138   4e-32
gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo sap...   138   4e-32
gi|40806170 spastin isoform 2 [Homo sapiens]                          137   5e-32
gi|11875211 spastin isoform 1 [Homo sapiens]                          137   5e-32
gi|31742536 fidgetin-like 1 [Homo sapiens]                            135   2e-31

>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score = 2763 bits (7162), Expect = 0.0
 Identities = 1390/1390 (100%), Positives = 1390/1390 (100%)

Query: 1    MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGS 60
            MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGS
Sbjct: 1    MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGS 60

Query: 61   SVKEVETYHRTRALRSLRKDAQNSSDSSFEKNVEITEQLANGRHFTRQLARQQADKKKEE 120
            SVKEVETYHRTRALRSLRKDAQNSSDSSFEKNVEITEQLANGRHFTRQLARQQADKKKEE
Sbjct: 61   SVKEVETYHRTRALRSLRKDAQNSSDSSFEKNVEITEQLANGRHFTRQLARQQADKKKEE 120

Query: 121  HREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNT 180
            HREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNT
Sbjct: 121  HREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNT 180

Query: 181  AEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEG 240
            AEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEG
Sbjct: 181  AEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEG 240

Query: 241  SVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRK 300
            SVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRK
Sbjct: 241  SVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRK 300

Query: 301  ATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDS 360
            ATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDS
Sbjct: 301  ATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDS 360

Query: 361  TSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLD 420
            TSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLD
Sbjct: 361  TSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLD 420

Query: 421  SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL 480
            SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL
Sbjct: 421  SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL 480

Query: 481  ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR 540
            ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR
Sbjct: 481  ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR 540

Query: 541  SSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPD 600
            SSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPD
Sbjct: 541  SSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPD 600

Query: 601  KEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYT 660
            KEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYT
Sbjct: 601  KEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYT 660

Query: 661  TSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEAL 720
            TSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEAL
Sbjct: 661  TSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEAL 720

Query: 721  QRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHL 780
            QRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHL
Sbjct: 721  QRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHL 780

Query: 781  NRNACYQPMSFRPRILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEE 840
            NRNACYQPMSFRPRILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEE
Sbjct: 781  NRNACYQPMSFRPRILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEE 840

Query: 841  TCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPH 900
            TCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPH
Sbjct: 841  TCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPH 900

Query: 901  SALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLP 960
            SALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLP
Sbjct: 901  SALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLP 960

Query: 961  VAPPPEPRSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPD 1020
            VAPPPEPRSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPD
Sbjct: 961  VAPPPEPRSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPD 1020

Query: 1021 YVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACA 1080
            YVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACA
Sbjct: 1021 YVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACA 1080

Query: 1081 LRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSD 1140
            LRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSD
Sbjct: 1081 LRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSD 1140

Query: 1141 PEQNEKLKTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIES 1200
            PEQNEKLKTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIES
Sbjct: 1141 PEQNEKLKTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIES 1200

Query: 1201 DTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTA 1260
            DTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTA
Sbjct: 1201 DTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTA 1260

Query: 1261 CTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILS 1320
            CTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILS
Sbjct: 1261 CTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILS 1320

Query: 1321 QPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQCIYRHRKDHDKTSLIQKME 1380
            QPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQCIYRHRKDHDKTSLIQKME
Sbjct: 1321 QPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQCIYRHRKDHDKTSLIQKME 1380

Query: 1381 QEVENFSCSR 1390
            QEVENFSCSR
Sbjct: 1381 QEVENFSCSR 1390


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score = 1218 bits (3151), Expect = 0.0
 Identities = 685/1344 (50%), Positives = 888/1344 (66%), Gaps = 155/1344 (11%)

Query: 149  NGDVEVRRSCRIR-SRYSGVNQSMLFDKLITNTAEAVLQKMDDMKKMRRQRMRELEDLGV 207
            NGD+EVR+SCR R +R+  VNQS+LFD+L+ +TAEAVLQ+MD++   + +R  E+E L +
Sbjct: 160  NGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRQNRRSGEVERLRM 219

Query: 208  FNETEESNLNMYTRGKQKDIQRTDEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDDD 267
            + +TE  N++MY+R K++               S+  +  G    HE   E E++E  ++
Sbjct: 220  WTDTEFENMDMYSRVKRR-------------RKSLRRNSYGIQNHHEVSTEGEEEESQEE 266

Query: 268  DDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRKATVYYQAPLEKPRHQRK-PNIFYSGPA 326
            D D          E EE   EEN + Y LRQRK    YQAP   P HQ+K  N  +    
Sbjct: 267  DGDI---------EVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHR 317

Query: 327  SPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDSTSSSSSEDEQHFERRRKRSRNRAINR 386
            SPAR  +              + R++HAIHSSD+TSS    DE+ FERR+ +S  RA NR
Sbjct: 318  SPARRSH--------------IRRKKHAIHSSDTTSS----DEERFERRKSKSMARARNR 359

Query: 387  CLPLNFRKDEL-KGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFP 445
            CLP+NFR ++L  GI ++R+K+GASLADVDPM +D SVRFDS+GGLS+HI ALKEMVVFP
Sbjct: 360  CLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFP 419

Query: 446  LLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKW 505
            LLYPE+FEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDK+VAFFMRKGADCLSKW
Sbjct: 420  LLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKW 479

Query: 506  VGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSR 565
            VGESERQLRLLFDQAY MRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLD+R
Sbjct: 480  VGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNR 539

Query: 566  GEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLE 625
            GEIVVIGATNRLDSIDPALRRPGRFDREFLF+LPD++ARK IL+IHTRDWNPK  D FL 
Sbjct: 540  GEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLG 599

Query: 626  ELAENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQK 685
            ELAE CVGYCGADIK++C EAAL ALRRRYPQIY +S KLQLD+SSI +SA+DF  AMQ 
Sbjct: 600  ELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQN 659

Query: 686  MIPASQRAVTSPGQALSTVVKPLLQNTVDKILEALQRVFPHAEFRTNKTLDSDISCPLLE 745
            ++PASQRAV S G ALS +++PLL+ + + IL  LQ+VFPHAE   +   + DI   +LE
Sbjct: 660  IVPASQRAVMSSGHALSPIIRPLLERSFNNILAVLQKVFPHAEISQSDKKE-DIETLILE 718

Query: 746  SDLAYSDDDVPSVYE----NGLSQKSSHKAKDNFNFLHLNRNACYQPMSFRPRILIVGEP 801
                  D++  S++E    +G  +K S  A  +  +LH   +  +QP S+RPR+L+ GE 
Sbjct: 719  DS---EDENALSIFETNCHSGSPKKQSSSAAIHKPYLHFTMSPYHQPTSYRPRLLLSGER 775

Query: 802  GFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAPSIVYVPH 861
            G GQ SHLAPA++H LE+F+V+ LD+P L+ VS  +PEE+CAQ+ REA+RT PSIVY+PH
Sbjct: 776  GSGQTSHLAPALLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPH 835

Query: 862  IHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPHSALPEEVQELFIRDYGEIFNV 921
            I  WWE V  T++ATF TLLQ+IPSF+P+ LL+TS+  +S LPEEV+ +F   Y E+  +
Sbjct: 836  IGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYI 895

Query: 922  QLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEPRSLTAEEVKRLEEQ 981
            Q P +E+R KFF++LIL QA+  P  +K A L A+EVLP+A P  PR L+  E  R+E+Q
Sbjct: 896  QRPIEEDRRKFFQELILNQASMAPPRRKHAALCAMEVLPLALPSPPRQLSESEKSRMEDQ 955

Query: 982  EEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLH 1041
            EE+T RELR+FLR+VT RLA DKRF +F+KPVD +EV DY+ VIK+PMDLS+VI+KID H
Sbjct: 956  EENTLRELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKH 1015

Query: 1042 KYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQLC 1101
             YLT KD+L+DIDLICSNALEYNPD+DPGD++IRHRAC L+DTA+AII  ELD +F +LC
Sbjct: 1016 NYLTAKDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLC 1075

Query: 1102 EEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKLKTPSTPVACSTPAQ 1161
            EEI+E+R KRG S +    + +    ++  T V +     ++N      ++   C+   +
Sbjct: 1076 EEIKEARIKRGLSVTSEQINPHSTGARKTETRVEEAFRHKQRNPMDVWHNSANKCAF--R 1133

Query: 1162 LKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAI--------DHKI-------------ES 1200
            ++RK R++S W  G IKKR+  +  KD+             D K+             E 
Sbjct: 1134 VRRKSRRRSQWGKGIIKKRKVNNLKKDEEDTKFADYENHTEDRKLLENGEFEVSTDCHEE 1193

Query: 1201 DTEETQDTSVDHNETG------------NTGESSVEENEKQQNASESKLELRNNSNTCNI 1248
            + EET D S+ ++E+             N G  + E     +  S ++  L N+S++ N 
Sbjct: 1194 NGEETGDLSMTNDESSCDIMDLDQGQRLNNGAGTKENFASTEEESSNESLLVNSSSSLNP 1253

Query: 1249 ENELEDSRKTT----------ACTELRDKIAC---------------NGD-ASSSQIIHI 1282
            E   + SRK T          A T+  + I                 +GD  SS Q I +
Sbjct: 1254 E---QTSRKETFLKGNCLNGEASTDSFEGIPVLECQNGKLEVVSFCDSGDKCSSEQKILL 1310

Query: 1283 SD----------ENEGKEMCVL------------------------------RMTRARRS 1302
             D          EN G ++  L                              ++ + R+ 
Sbjct: 1311 EDQSKEKPETSTENHGDDLEKLEALECSNNEKLEPGSDVEVKDAELDKEGASKVKKYRKL 1370

Query: 1303 QVEQQQLITVEKALAILSQPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQC 1362
             +EQ +  ++E      S+P P L+VD ERLK LL  +V KS N  + QLE LY+++SQC
Sbjct: 1371 ILEQAKTTSLELVPEEPSEPVPPLIVDRERLKKLLDLLVDKSNNLAVDQLERLYSLLSQC 1430

Query: 1363 IYRHRKDHDKTSLIQKMEQEVENF 1386
            IYRHRKD+DK+ L+++ME+ V  F
Sbjct: 1431 IYRHRKDYDKSQLVEEMERTVHMF 1454


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  223 bits (569), Expect = 8e-58
 Identities = 119/273 (43%), Positives = 171/273 (62%), Gaps = 7/273 (2%)

Query: 421 SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL 480
           + V +D +GG    +A +KEMV  PL +P +F+   ++PPRG L YGPPGTGKTL+ARA+
Sbjct: 199 NEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAV 258

Query: 481 ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR 540
           ANE         FF+  G + +SK  GESE  LR  F++A +  P+IIF DE+D +AP R
Sbjct: 259 ANETG-----AFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR 313

Query: 541 SSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPD 600
                ++   IVS LL LMDGL  R  ++V+ ATNR +SIDPALRR GRFDRE    +PD
Sbjct: 314 EKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPD 373

Query: 601 KEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYT 660
              R EIL+IHT++      D  LE++A    G+ GAD+ ++C+EAAL A+R++   I  
Sbjct: 374 ATGRLEILQIHTKNMKLAD-DVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDL 432

Query: 661 TSEKLQLD-LSSINISAKDFEVAMQKMIPASQR 692
             E +  + ++S+ ++  DF  A+ +  P++ R
Sbjct: 433 EDETIDAEVMNSLAVTMDDFRWALSQSNPSALR 465



 Score =  182 bits (461), Expect = 3e-45
 Identities = 99/259 (38%), Positives = 149/259 (57%), Gaps = 9/259 (3%)

Query: 423 VRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 482
           V ++ +GGL +    L+E+V +P+ +P+ F KF + P +G LFYGPPG GKTL+A+A+AN
Sbjct: 474 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIAN 533

Query: 483 ECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSS 542
           EC     +  F   KG + L+ W GESE  +R +FD+A Q  P ++FFDE+D +A  R  
Sbjct: 534 EC-----QANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGG 588

Query: 543 RQDQ---IHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLP 599
                      +++ +L  MDG+ ++  + +IGATNR D IDPA+ RPGR D+     LP
Sbjct: 589 NIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLP 648

Query: 600 DKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIY 659
           D+++R  ILK + R  +P   D  LE LA+   G+ GAD+  IC  A   A+R       
Sbjct: 649 DEKSRVAILKANLRK-SPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEI 707

Query: 660 TTSEKLQLDLSSINISAKD 678
               + Q + S++ +   D
Sbjct: 708 RRERERQTNPSAMEVEEDD 726



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 45/205 (21%), Positives = 86/205 (41%), Gaps = 38/205 (18%)

Query: 778 LHLNRNACYQPMSFRPR--ILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVST 835
           L L   A ++ +  +P   IL+ G PG G+ + +A AV +    F  + ++ P +     
Sbjct: 222 LPLRHPALFKAIGVKPPRGILLYGPPGTGK-TLIARAVANETGAF-FFLINGPEIMSKLA 279

Query: 836 TSPEETCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKAT-----------FTTLLQNI 884
              E    +   EA++ AP+I+++  +    + + P  + T             TL+  +
Sbjct: 280 GESESNLRKAFEEAEKNAPAIIFIDEL----DAIAPKREKTHGEVERRIVSQLLTLMDGL 335

Query: 885 PSFAPVLLLATSDKPHSALPEEVQELFIRDYGEI---FNVQLPDKEER----------TK 931
              A V+++A +++P+S  P       +R +G      ++ +PD   R           K
Sbjct: 336 KQRAHVIVMAATNRPNSIDPA------LRRFGRFDREVDIGIPDATGRLEILQIHTKNMK 389

Query: 932 FFEDLILKQAAKPPISKKKAVLQAL 956
             +D+ L+Q A        A L AL
Sbjct: 390 LADDVDLEQVANETHGHVGADLAAL 414


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  204 bits (520), Expect = 4e-52
 Identities = 113/275 (41%), Positives = 168/275 (61%), Gaps = 10/275 (3%)

Query: 423 VRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 482
           V +D +GGLS+ + A++E++  PL  PE+F+ + I  PRG L YGPPGTGKT++ARA+AN
Sbjct: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409

Query: 483 ECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSS 542
           E           +  G + +SK+ GE+E +LR +F +A    PSIIF DE+D L P R  
Sbjct: 410 EVG-----AYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREG 464

Query: 543 RQDQIHSSIVSTLLALMDGLD---SRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLP 599
            Q+++   +V++LL LMDG+    S G+++V+GATNR  ++D ALRRPGRFD+E    +P
Sbjct: 465 AQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVP 524

Query: 600 DKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIY 659
           + + R +IL+   R       +  L +LA +  GY GAD+K +C EA LCALRR   +  
Sbjct: 525 NAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQP 584

Query: 660 TTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAV 694
              +     L  + I+ KDF  AM  + P++ R +
Sbjct: 585 NLPDVKVAGL--VKITLKDFLQAMNDIRPSAMREI 617



 Score =  172 bits (436), Expect = 2e-42
 Identities = 98/232 (42%), Positives = 137/232 (59%), Gaps = 8/232 (3%)

Query: 422 SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALA 481
           +V +  +GGL +    L++ V +PL +PE F +  IQPP+G L YGPPG  KT++A+ALA
Sbjct: 623 NVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALA 682

Query: 482 NECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRS 541
           NE       + F   KG + ++K+VGESER +R  F +A  + PSIIFFDE+D LA  R 
Sbjct: 683 NESG-----LNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERG 737

Query: 542 SR--QDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLP 599
           S      +   +++ LL  MDG++   ++ ++ ATNR D ID AL RPGR DR     LP
Sbjct: 738 SSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLP 797

Query: 600 DKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCAL 651
           D   R+EI K+      P   +  L+EL      Y GA+I ++C EAAL AL
Sbjct: 798 DAATRREIFKLQFHSM-PVSNEVDLDELILQTDAYSGAEIVAVCREAALLAL 848


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  188 bits (477), Expect = 4e-47
 Identities = 109/263 (41%), Positives = 152/263 (57%), Gaps = 15/263 (5%)

Query: 401 YKDRMKIGASLADVDPMQLDSSVR------FDSVGGLSNHIAALKEMVVFPLLYPEVFEK 454
           +K    IG  + D DP+     V       +  +GGL N I  +KE V  PL +PE +E+
Sbjct: 154 HKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEE 213

Query: 455 FKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLR 514
             I+PP+G + YGPPGTGKTL+A+A+AN+ S    RV      G++ + K++G+  + +R
Sbjct: 214 MGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVV-----GSELIQKYLGDGPKLVR 268

Query: 515 LLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDSRGEIVVI 571
            LF  A +  PSI+F DEID +   R          I  T+L L   +DG DSRG++ VI
Sbjct: 269 ELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVI 328

Query: 572 GATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENC 631
            ATNR++++DPAL RPGR DR+  F LPD++ +K I +IHT        D  L++L    
Sbjct: 329 MATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLAD-DVTLDDLIMAK 387

Query: 632 VGYCGADIKSICAEAALCALRRR 654
               GADIK+IC EA L ALR R
Sbjct: 388 DDLSGADIKAICTEAGLMALRER 410


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  183 bits (465), Expect = 9e-46
 Identities = 114/277 (41%), Positives = 157/277 (56%), Gaps = 18/277 (6%)

Query: 389 PLNFRKDELKGIYKDRMKIGASLAD-VDP----MQLDSS--VRFDSVGGLSNHIAALKEM 441
           P +  +    G+ +++ +I   L   +DP    MQ++    V +  VGG    I  L+E+
Sbjct: 131 PTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREV 190

Query: 442 VVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRK-GAD 500
           V  PLL+PE F    I+PP+G L +GPPGTGKTL ARA+AN         A F+R  G++
Sbjct: 191 VETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTD------ACFIRVIGSE 244

Query: 501 CLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL-- 558
            + K+VGE  R +R LF+ A   +  +IFFDEID +   R        + +  T+L L  
Sbjct: 245 LVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELIN 304

Query: 559 -MDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNP 617
            +DG D RG I V+ ATNR D++DPAL RPGR DR+  FSLPD E R  I KIH R  + 
Sbjct: 305 QLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSV 364

Query: 618 KPLDTFLEELAENCVGYCGADIKSICAEAALCALRRR 654
           +  D   E LA  C    GA+I+S+C EA + A+R R
Sbjct: 365 E-RDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRAR 400


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  177 bits (449), Expect = 6e-44
 Identities = 101/265 (38%), Positives = 154/265 (58%), Gaps = 11/265 (4%)

Query: 425 FDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANEC 484
           ++ +GGL   I  +KE++  P+ +PE+FE   I  P+G L YGPPGTGKTL+ARA+A+  
Sbjct: 148 YEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHT 207

Query: 485 SQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSSRQ 544
                   F    G++ + K++GE  R +R LF  A +  PSIIF DEID +   R    
Sbjct: 208 D-----CTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGG 262

Query: 545 DQIHSSIVSTLLAL---MDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDK 601
               S +  T+L L   +DG ++   I VI ATNR+D +D AL RPGR DR+  F  P++
Sbjct: 263 SGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNE 322

Query: 602 EARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYTT 661
           EAR +ILKIH+R  N       L ++AE   G  GA++K +C EA + ALR R  +++ T
Sbjct: 323 EARLDILKIHSRKMN-LTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRER--RVHVT 379

Query: 662 SEKLQLDLSSINISAKDFEVAMQKM 686
            E  ++ ++ +     +  ++++K+
Sbjct: 380 QEDFEMAVAKVMQKDSEKNMSIKKL 404


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  176 bits (446), Expect = 1e-43
 Identities = 133/445 (29%), Positives = 211/445 (47%), Gaps = 51/445 (11%)

Query: 237 NQEGSVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKRYYL 296
           + E  +++  E ED+         +++++  +   DDD   ED  D +     N     L
Sbjct: 67  SSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSL 126

Query: 297 ---------------RQRKATVYY--------QAPLEKPRHQRKPNIFYSGPASPARPRY 333
                           QR+ T             PL+ P    +   F     S  +  +
Sbjct: 127 YRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSF 186

Query: 334 RLSSAGPRSPYCKRMNRRRHAIHSSDSTSSSSSEDEQHFERRRKRSRNRAINRCLPLNFR 393
            L  +      C++ N ++      DS  SS  E +    +R+ + +N+   R      +
Sbjct: 187 FLDLS------CEKSNPKKPITEIQDSKDSSLLESDM---KRKGKLKNKGSKR------K 231

Query: 394 KDELKGIYKDRMKIGASLADVDPMQLD-SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVF 452
           K++L+ +  +   +    A    ++   S+V+F+ VGG    +  + +M++  + +PEV+
Sbjct: 232 KEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIH-MRHPEVY 290

Query: 453 EKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQ 512
               + PPRG L +GPPG GKTL+A A+A E      +VA       + +S   GESE++
Sbjct: 291 HHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVA-----APEIVSGVSGESEQK 345

Query: 513 LRLLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDS---RGEIV 569
           LR LF+QA    P IIF DEID + P R      +   IV+ LL  MD L++      ++
Sbjct: 346 LRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVL 405

Query: 570 VIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWN-PKPLDTFLEELA 628
           VIGATNR DS+DPALRR GRFDRE    +PD+ +R+ IL+   R    P+  D     LA
Sbjct: 406 VIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFD--FCHLA 463

Query: 629 ENCVGYCGADIKSICAEAALCALRR 653
               G+ GAD+ ++C EAA+CA+ R
Sbjct: 464 HLTPGFVGADLMALCREAAMCAVNR 488



 Score =  171 bits (434), Expect = 3e-42
 Identities = 102/269 (37%), Positives = 152/269 (56%), Gaps = 14/269 (5%)

Query: 422 SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALA 481
           +V +  +G L +    L   ++ P+  P+ F+   +  P G L  GPPG GKTL+A+A+A
Sbjct: 577 NVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVA 636

Query: 482 NECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRS 541
           NE       + F   KG + L+ +VGESER +R +F +A    P +IFFDE+D L P RS
Sbjct: 637 NESG-----LNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRS 691

Query: 542 SRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDK 601
            R+      +V+ LL  MDGL++R ++ ++ ATNR D IDPA+ RPGR D+     LP  
Sbjct: 692 DRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPP 751

Query: 602 EARKEILKIHTRDWNPKPL--DTFLEELAEN--CVGYCGADIKSICAEAALCALRRRYPQ 657
             R  ILK  T++    PL  D  LE +A +  C  Y GAD+ ++  EA++CALR+   +
Sbjct: 752 ADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMAR 811

Query: 658 IYTTSEKLQLDLSSINISAKDFEVAMQKM 686
             + +EK       + +S K FE A +K+
Sbjct: 812 QKSGNEK-----GELKVSHKHFEEAFKKV 835


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  174 bits (441), Expect = 5e-43
 Identities = 100/249 (40%), Positives = 147/249 (59%), Gaps = 15/249 (6%)

Query: 413 DVDPMQLDSS------VRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFY 466
           +VDP+  + S      V +  +GGLS  I  L+E++  PL  PE+F++  I PP+GCL Y
Sbjct: 128 EVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLY 187

Query: 467 GPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPS 526
           GPPGTGKTL+ARA+A++      +V       +  + K++GES R +R +F+ A   +P 
Sbjct: 188 GPPGTGKTLLARAVASQLDCNFLKVV-----SSSIVDKYIGESARLIREMFNYARDHQPC 242

Query: 527 IIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDSRGEIVVIGATNRLDSIDPA 583
           IIF DEID +   R S        I  TL+ L   MDG D+   + +I ATNR D++DPA
Sbjct: 243 IIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPA 302

Query: 584 LRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSIC 643
           L RPGR DR+    LP+++AR +ILKIH      K  +   E + +   G+ GAD++++C
Sbjct: 303 LLRPGRLDRKIHIDLPNEQARLDILKIHAGPIT-KHGEIDYEAIVKLSDGFNGADLRNVC 361

Query: 644 AEAALCALR 652
            EA + A+R
Sbjct: 362 TEAGMFAIR 370


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  173 bits (438), Expect = 1e-42
 Identities = 112/314 (35%), Positives = 172/314 (54%), Gaps = 22/314 (7%)

Query: 345 CKRMNRRRHAIHSSDSTSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDR 404
           C++ N ++      DS  SS  E +    +R+ + +N+   R      +K++L+ +  + 
Sbjct: 86  CEKSNPKKPITEIQDSKDSSLLESDM---KRKGKLKNKGSKR------KKEDLQEVDGEI 136

Query: 405 MKIGASLADVDPMQLD-SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGC 463
             +    A    ++   S+V+F+ VGG    +  + +M++  + +PEV+    + PPRG 
Sbjct: 137 EAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIH-MRHPEVYHHLGVVPPRGV 195

Query: 464 LFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQM 523
           L +GPPG GKTL+A A+A E      +VA       + +S   GESE++LR LF+QA   
Sbjct: 196 LLHGPPGCGKTLLAHAIAGELDLPILKVA-----APEIVSGVSGESEQKLRELFEQAVSN 250

Query: 524 RPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDS---RGEIVVIGATNRLDSI 580
            P IIF DEID + P R      +   IV+ LL  MD L++      ++VIGATNR DS+
Sbjct: 251 APCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSL 310

Query: 581 DPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWN-PKPLDTFLEELAENCVGYCGADI 639
           DPALRR GRFDRE    +PD+ +R+ IL+   R    P+  D     LA    G+ GAD+
Sbjct: 311 DPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFD--FCHLAHLTPGFVGADL 368

Query: 640 KSICAEAALCALRR 653
            ++C EAA+CA+ R
Sbjct: 369 MALCREAAMCAVNR 382



 Score =  171 bits (434), Expect = 3e-42
 Identities = 102/269 (37%), Positives = 152/269 (56%), Gaps = 14/269 (5%)

Query: 422 SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALA 481
           +V +  +G L +    L   ++ P+  P+ F+   +  P G L  GPPG GKTL+A+A+A
Sbjct: 471 NVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVA 530

Query: 482 NECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRS 541
           NE       + F   KG + L+ +VGESER +R +F +A    P +IFFDE+D L P RS
Sbjct: 531 NESG-----LNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRS 585

Query: 542 SRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDK 601
            R+      +V+ LL  MDGL++R ++ ++ ATNR D IDPA+ RPGR D+     LP  
Sbjct: 586 DRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPP 645

Query: 602 EARKEILKIHTRDWNPKPL--DTFLEELAEN--CVGYCGADIKSICAEAALCALRRRYPQ 657
             R  ILK  T++    PL  D  LE +A +  C  Y GAD+ ++  EA++CALR+   +
Sbjct: 646 ADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMAR 705

Query: 658 IYTTSEKLQLDLSSINISAKDFEVAMQKM 686
             + +EK       + +S K FE A +K+
Sbjct: 706 QKSGNEK-----GELKVSHKHFEEAFKKV 729


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  169 bits (429), Expect = 1e-41
 Identities = 102/268 (38%), Positives = 146/268 (54%), Gaps = 16/268 (5%)

Query: 396 ELKGIYKDRMKIGASL-----ADVDPMQLDS--SVRFDSVGGLSNHIAALKEMVVFPLLY 448
           +L G+ KD   I  +L     + V  M++D   + ++  +GGL   I  L E +V P+ +
Sbjct: 149 DLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNH 208

Query: 449 PEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGE 508
            E FE   IQPP+G L YGPPGTGKTL+ARA A        +  F    G   +  ++G+
Sbjct: 209 KEKFENLGIQPPKGVLMYGPPGTGKTLLARACA-----AQTKATFLKLAGPQLVQMFIGD 263

Query: 509 SERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDSR 565
             + +R  F  A +  PSIIF DE+D +   R   +      +  T+L L   +DG    
Sbjct: 264 GAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPN 323

Query: 566 GEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLE 625
            ++ VI ATNR+D +DPAL R GR DR+  F +P++EAR  I++IH+R  N  P D   E
Sbjct: 324 TQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSP-DVNYE 382

Query: 626 ELAENCVGYCGADIKSICAEAALCALRR 653
           ELA     + GA  K++C EA + ALRR
Sbjct: 383 ELARCTDDFNGAQCKAVCVEAGMIALRR 410


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  162 bits (410), Expect = 2e-39
 Identities = 108/270 (40%), Positives = 150/270 (55%), Gaps = 22/270 (8%)

Query: 428 VGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQG 487
           +GGLS    +L+E++  PL YP       +  PRG L  GPPG GKT + RA+A E    
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261

Query: 488 DKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMR---PSIIFFDEIDGLAPVRSSRQ 544
              V+    +G+       GE+E  +R +F +A ++    PS++F DE+D L P R SR 
Sbjct: 262 LLAVSAPALQGSR-----PGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSRA 316

Query: 545 DQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEAR 604
            +  S +V+ +L L+DG     E+VV+GATNR D++DPALRRPGRFDRE +   P  + R
Sbjct: 317 PE--SRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQR 374

Query: 605 KEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEK 664
           KEIL++ T    P      L  LAE  VGY GAD+ ++C EAA+ AL          SEK
Sbjct: 375 KEILQVITSKM-PISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLH--------SEK 425

Query: 665 LQLDLSSINISAKDFEVAMQKMIPASQRAV 694
            Q    +  I   DF  A + + P+S R+V
Sbjct: 426 NQ---DNPVIDEIDFLEAFKNIQPSSFRSV 452



 Score =  148 bits (373), Expect = 4e-35
 Identities = 96/279 (34%), Positives = 141/279 (50%), Gaps = 33/279 (11%)

Query: 395 DELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEK 454
           +  K I     +    L D+ P      V ++ +GGL +    LK+ + +PL +P  F +
Sbjct: 439 EAFKNIQPSSFRSVIGLMDIKP------VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVR 492

Query: 455 FKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLR 514
             +  P+G L YGPPG  KT + RALA  C       +F    GAD  S +VG+SE+ L 
Sbjct: 493 MGLTQPKGVLLYGPPGCAKTTLVRALATSC-----HCSFVSVSGADLFSPFVGDSEKVLS 547

Query: 515 LLFDQAYQMRPSIIFFDEIDGLAPVRSSRQD--QIHSSIVSTLLALMDG-----LDSRG- 566
            +F QA    P+I+F DEID +   RS+ +    +   ++S LL  +DG     ++ RG 
Sbjct: 548 QIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGS 607

Query: 567 -------------EIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTR 613
                         +++I ATNR D +D AL RPGR D+      PD + R  ILK+ T+
Sbjct: 608 KSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTK 667

Query: 614 DWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALR 652
                P D  LE LA     + GAD++++C EAAL AL+
Sbjct: 668 TMPIGP-DVSLENLAAETCFFSGADLRNLCTEAALLALQ 705


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  160 bits (405), Expect = 8e-39
 Identities = 127/389 (32%), Positives = 197/389 (50%), Gaps = 43/389 (11%)

Query: 314 HQRKPNIFYSGPASPARP-RYRLSSAGPRSPYCKRMNRRRHAIHSSDSTSSSSSEDEQ-- 370
           H+  P I    P    RP R  ++  G R P       R H I  S+  S+S  +D +  
Sbjct: 107 HRAPPQI--RRPNREVRPLRKEMAGVGARGPV-----GRAHPISKSEKPSTSRDKDYRAR 159

Query: 371 -HFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVG 429
              ++ RK  ++ A +  +P    K +  G  KD ++      + D +  + S+ +D + 
Sbjct: 160 GRDDKGRKNMQDGASDGEMP----KFDGAGYDKDLVEA----LERDIVSRNPSIHWDDIA 211

Query: 430 GLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDK 489
            L      L+E VV P+  P+ F+  + +P +G L  GPPGTGKT++A+A+A EC     
Sbjct: 212 DLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTMLAKAVATECG---- 266

Query: 490 RVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR-SSRQDQIH 548
              FF    +   SK+ GESE+ +RLLF+ A    P+ IF DEID +   R +S + +  
Sbjct: 267 -TTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEAS 325

Query: 549 SSIVSTLLALMDGL-------DSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDK 601
             + S LL  MDG+       D    ++V+ ATN    ID ALRR  R ++     LP  
Sbjct: 326 RRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPTA 383

Query: 602 EARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRY----PQ 657
           + R E+LKI+ R+    P D  LE++AE   GY GADI ++C +A+L A+RRR     P+
Sbjct: 384 KGRAELLKINLREVELDP-DIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPE 442

Query: 658 IYTTSEKLQLDLSSINISAKDFEVAMQKM 686
                 K +L +    ++  DFE+A++K+
Sbjct: 443 EIRALSKEELQMP---VTKGDFELALKKI 468


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  160 bits (405), Expect = 8e-39
 Identities = 127/389 (32%), Positives = 197/389 (50%), Gaps = 43/389 (11%)

Query: 314 HQRKPNIFYSGPASPARP-RYRLSSAGPRSPYCKRMNRRRHAIHSSDSTSSSSSEDEQ-- 370
           H+  P I    P    RP R  ++  G R P       R H I  S+  S+S  +D +  
Sbjct: 107 HRAPPQI--RRPNREVRPLRKEMAGVGARGPV-----GRAHPISKSEKPSTSRDKDYRAR 159

Query: 371 -HFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVG 429
              ++ RK  ++ A +  +P    K +  G  KD ++      + D +  + S+ +D + 
Sbjct: 160 GRDDKGRKNMQDGASDGEMP----KFDGAGYDKDLVEA----LERDIVSRNPSIHWDDIA 211

Query: 430 GLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDK 489
            L      L+E VV P+  P+ F+  + +P +G L  GPPGTGKT++A+A+A EC     
Sbjct: 212 DLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTMLAKAVATECG---- 266

Query: 490 RVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR-SSRQDQIH 548
              FF    +   SK+ GESE+ +RLLF+ A    P+ IF DEID +   R +S + +  
Sbjct: 267 -TTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEAS 325

Query: 549 SSIVSTLLALMDGL-------DSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDK 601
             + S LL  MDG+       D    ++V+ ATN    ID ALRR  R ++     LP  
Sbjct: 326 RRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPTA 383

Query: 602 EARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRY----PQ 657
           + R E+LKI+ R+    P D  LE++AE   GY GADI ++C +A+L A+RRR     P+
Sbjct: 384 KGRAELLKINLREVELDP-DIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPE 442

Query: 658 IYTTSEKLQLDLSSINISAKDFEVAMQKM 686
                 K +L +    ++  DFE+A++K+
Sbjct: 443 EIRALSKEELQMP---VTKGDFELALKKI 468


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  157 bits (398), Expect = 5e-38
 Identities = 101/271 (37%), Positives = 154/271 (56%), Gaps = 13/271 (4%)

Query: 422 SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALA 481
           SV +  VGGL      + E +  PL +PE+      +   G L +GPPGTGKTL+A+A+A
Sbjct: 701 SVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAVA 758

Query: 482 NECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRS 541
            ECS     + F   KG + ++ +VG+SE  +R +F +A    P IIFFDE+D LAP R 
Sbjct: 759 TECS-----LTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRG 813

Query: 542 SRQDQ--IHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDR-EFLFSL 598
              D   +   +VS LLA +DGL S  ++ VIGATNR D +DPAL RPGRFD+  F+ + 
Sbjct: 814 RSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGAN 873

Query: 599 PDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQI 658
            D+ ++  +L   TR +  +P  + +  L        GAD+ S+C++A   AL+RR   +
Sbjct: 874 EDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRR---V 930

Query: 659 YTTSEKLQLDLSSINISAKDFEVAMQKMIPA 689
           +   E L+   S++ ++ +D   A  ++ P+
Sbjct: 931 HDLEEGLEPGSSALMLTMEDLLQAAARLQPS 961



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 64/271 (23%), Positives = 116/271 (42%), Gaps = 14/271 (5%)

Query: 464 LFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQM 523
           L  GPPG GKT V  A  +       +V       +   ++  G  E +L+ +F +A + 
Sbjct: 467 LLRGPPGCGKTTVVAAACSHLGLHLLKVPC-----SSLCAESSGAVETKLQAIFSRARRC 521

Query: 524 RPSIIFFDEIDGLAPVRSS-RQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDP 582
           RP+++    +D L   R    +D    +++  LL   D L+S   ++V+  T+R   +  
Sbjct: 522 RPAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPA 581

Query: 583 ALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSI 642
            ++    F  E       +  R  IL+  T    P   +  L +LA  C G+   D+ ++
Sbjct: 582 DVQT--AFPHELEVPALSEGQRLSILRALTAHL-PLGQEVNLAQLARRCAGFVVGDLYAL 638

Query: 643 CAEAALCALRR----RYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPG 698
              ++  A  R          T  ++ +L  +   + A+DF  A++++  A  +AV +P 
Sbjct: 639 LTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPK 698

Query: 699 -QALSTVVKPLLQNTVDKILEALQRVFPHAE 728
             ++S      LQ    +ILE +Q    H E
Sbjct: 699 IPSVSWHDVGGLQEVKKEILETIQLPLEHPE 729


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  155 bits (392), Expect = 3e-37
 Identities = 104/297 (35%), Positives = 152/297 (51%), Gaps = 36/297 (12%)

Query: 410 SLADVDPMQLDSS-----------VRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQ 458
           +L DV P + DSS           V +  +GG+      ++E V  PL + E++++  I 
Sbjct: 134 ALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGID 193

Query: 459 PPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFD 518
           PPRG L YGPPG GKT++A+A+A+  +      AF    G++ + K++GE  R +R +F 
Sbjct: 194 PPRGVLMYGPPGCGKTMLAKAVAHHTT-----AAFIRVVGSEFVQKYLGEGPRMVRDVFR 248

Query: 519 QAYQMRPSIIFFDEIDGLAPVRSSRQ---DQIHSSIVSTLLALMDGLDSRGEIVVIGATN 575
            A +  P+IIF DEID +A  R   Q   D+    I+  LL  MDG D    + VI ATN
Sbjct: 249 LAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATN 308

Query: 576 RLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYC 635
           R D++DPAL RPGR DR+  F LPD+  ++ I    T   N    +  LE+         
Sbjct: 309 RADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSE-EVDLEDYVARPDKIS 367

Query: 636 GADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQR 692
           GADI SIC E+ + A+R                 +   + AKDFE A + +I   ++
Sbjct: 368 GADINSICQESGMLAVRE----------------NRYIVLAKDFEKAYKTVIKKDEQ 408


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  155 bits (392), Expect = 3e-37
 Identities = 104/297 (35%), Positives = 152/297 (51%), Gaps = 36/297 (12%)

Query: 410 SLADVDPMQLDSS-----------VRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQ 458
           +L DV P + DSS           V +  +GG+      ++E V  PL + E++++  I 
Sbjct: 107 ALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGID 166

Query: 459 PPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFD 518
           PPRG L YGPPG GKT++A+A+A+  +      AF    G++ + K++GE  R +R +F 
Sbjct: 167 PPRGVLMYGPPGCGKTMLAKAVAHHTT-----AAFIRVVGSEFVQKYLGEGPRMVRDVFR 221

Query: 519 QAYQMRPSIIFFDEIDGLAPVRSSRQ---DQIHSSIVSTLLALMDGLDSRGEIVVIGATN 575
            A +  P+IIF DEID +A  R   Q   D+    I+  LL  MDG D    + VI ATN
Sbjct: 222 LAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATN 281

Query: 576 RLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYC 635
           R D++DPAL RPGR DR+  F LPD+  ++ I    T   N    +  LE+         
Sbjct: 282 RADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSE-EVDLEDYVARPDKIS 340

Query: 636 GADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQR 692
           GADI SIC E+ + A+R                 +   + AKDFE A + +I   ++
Sbjct: 341 GADINSICQESGMLAVRE----------------NRYIVLAKDFEKAYKTVIKKDEQ 381


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  155 bits (392), Expect = 3e-37
 Identities = 104/297 (35%), Positives = 152/297 (51%), Gaps = 36/297 (12%)

Query: 410 SLADVDPMQLDSS-----------VRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQ 458
           +L DV P + DSS           V +  +GG+      ++E V  PL + E++++  I 
Sbjct: 138 ALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGID 197

Query: 459 PPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFD 518
           PPRG L YGPPG GKT++A+A+A+  +      AF    G++ + K++GE  R +R +F 
Sbjct: 198 PPRGVLMYGPPGCGKTMLAKAVAHHTT-----AAFIRVVGSEFVQKYLGEGPRMVRDVFR 252

Query: 519 QAYQMRPSIIFFDEIDGLAPVRSSRQ---DQIHSSIVSTLLALMDGLDSRGEIVVIGATN 575
            A +  P+IIF DEID +A  R   Q   D+    I+  LL  MDG D    + VI ATN
Sbjct: 253 LAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATN 312

Query: 576 RLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYC 635
           R D++DPAL RPGR DR+  F LPD+  ++ I    T   N    +  LE+         
Sbjct: 313 RADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSE-EVDLEDYVARPDKIS 371

Query: 636 GADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQR 692
           GADI SIC E+ + A+R                 +   + AKDFE A + +I   ++
Sbjct: 372 GADINSICQESGMLAVRE----------------NRYIVLAKDFEKAYKTVIKKDEQ 412


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  154 bits (389), Expect = 6e-37
 Identities = 103/282 (36%), Positives = 156/282 (55%), Gaps = 20/282 (7%)

Query: 415 DPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKT 474
           D +  + +VR+D +  L      LKE VV P+  PE F+  + +P +G L  GPPGTGKT
Sbjct: 198 DIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIR-RPWKGVLMVGPPGTGKT 256

Query: 475 LVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEID 534
           L+A+A+A EC     +  FF    +   SK+ GESE+ +RLLF+ A    P+ IF DEID
Sbjct: 257 LLAKAVATEC-----KTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEID 311

Query: 535 GLAPVR-SSRQDQIHSSIVSTLLALMDGLDSRGE-------IVVIGATNRLDSIDPALRR 586
            +   R +S + +    + + LL  MDG+    E       ++V+ ATN    ID ALRR
Sbjct: 312 SICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR 371

Query: 587 PGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEA 646
             R ++     LP  + R+E+L+I  R+      D  L  +AEN  GY GADI ++C +A
Sbjct: 372 --RLEKRIYIPLPSAKGREELLRISLRELELAD-DVDLASIAENMEGYSGADITNVCRDA 428

Query: 647 ALCALRRRYPQIYTTSEKLQLDLSSINI--SAKDFEVAMQKM 686
           +L A+RRR   + T  E   L    +++  + +DFE+A++K+
Sbjct: 429 SLMAMRRRIEGL-TPEEIRNLSKEEMHMPTTMEDFEMALKKV 469


>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
          Length = 437

 Score =  149 bits (375), Expect = 2e-35
 Identities = 99/313 (31%), Positives = 162/313 (51%), Gaps = 19/313 (6%)

Query: 352 RHAIHSSDSTSSSSSEDEQHFERRRKRS---RNRAINRCLPLNFRKDELKGIYKD----- 403
           ++  HS  +  S  ++  Q+ +R  K     R++  +   P+   + E KG   D     
Sbjct: 44  KYEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDN 103

Query: 404 --RMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPR 461
             + K+   L     M+   ++R++ V GL     ALKE V+ P+ +P +F   K  P R
Sbjct: 104 PEKKKLQEQLMGAVVME-KPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWR 161

Query: 462 GCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAY 521
           G L +GPPGTGK+ +A+A+A E +       FF    +D +SKW+GESE+ ++ LF+ A 
Sbjct: 162 GILLFGPPGTGKSYLAKAVATEANNS----TFFSVSSSDLMSKWLGESEKLVKNLFELAR 217

Query: 522 QMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGE-IVVIGATNRLDSI 580
           Q +PSIIF DE+D L   R+  + +    I +  L  M G+ +  +  +V+GATN    +
Sbjct: 218 QHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVL 277

Query: 581 DPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIK 640
           D A+RR  RF++     LP++ AR ++ ++H         D  + ELA    GY GADI 
Sbjct: 278 DSAIRR--RFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADIS 335

Query: 641 SICAEAALCALRR 653
            I  ++ +  +R+
Sbjct: 336 IIVRDSLMQPVRK 348


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  148 bits (374), Expect = 3e-35
 Identities = 91/243 (37%), Positives = 133/243 (54%), Gaps = 7/243 (2%)

Query: 409  ASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGP 468
            ASL  V+ +     + +D +GGL      L + +  P  YPE+F    I+   G L YGP
Sbjct: 824  ASLRSVN-LHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGP 882

Query: 469  PGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSII 528
            PGTGKTL+A  +A E      R+ F   KG + LSK++G SE+ +R +F +A   +P I+
Sbjct: 883  PGTGKTLLAGVIARE-----SRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCIL 937

Query: 529  FFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPG 588
            FFDE + +AP R      +   +V+ LL  +DG++    + V+ AT+R D IDPAL RPG
Sbjct: 938  FFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPG 997

Query: 589  RFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAAL 648
            R D+      PD+ +R EIL +   D  P   D  L+ +A     + GAD+K++   A L
Sbjct: 998  RLDKCVYCPPPDQVSRLEILNV-LSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQL 1056

Query: 649  CAL 651
             AL
Sbjct: 1057 EAL 1059



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 64/246 (26%), Positives = 108/246 (43%), Gaps = 27/246 (10%)

Query: 464 LFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCL-SKWVGESERQLRLLFDQAYQ 522
           L  G  G+GK+ +A+A+  E    DK  A   R     L  K +   ++ L + F +A  
Sbjct: 596 LLTGGKGSGKSTLAKAICKEAF--DKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVW 653

Query: 523 MRPSIIFFDEIDGLA-----PVRSSRQDQIHSS-IVSTLLALMDGLDSRGEIVVIGATNR 576
           M+PS++  D++D +A     P      D + S  +   L  ++    S G +V + AT++
Sbjct: 654 MQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQ 713

Query: 577 LD-SIDPAL---RRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTF----LEELA 628
              S+ P L   +    F        P++E R EIL    ++     ++ F    L+ +A
Sbjct: 714 SQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVA 773

Query: 629 ENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIP 688
           +   G+   D   +   A    L R   Q  +T EKL L       +  DF+ A++  +P
Sbjct: 774 KETGGFVARDFTVLVDRAIHSRLSR---QSISTREKLVL-------TTLDFQKALRGFLP 823

Query: 689 ASQRAV 694
           AS R+V
Sbjct: 824 ASLRSV 829


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  144 bits (362), Expect = 8e-34
 Identities = 97/286 (33%), Positives = 156/286 (54%), Gaps = 20/286 (6%)

Query: 405 MKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKI-QPPRGC 463
           M I A L  VDP+ +   V +  + GL + I  LK+ V+ P+    +FE  ++ QPP+G 
Sbjct: 74  MSIAAHL--VDPLNMH--VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGV 129

Query: 464 LFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQM 523
           L YGPPG GKTL+A+A A E         F   + +    KW GES++    +F  A ++
Sbjct: 130 LLYGPPGCGKTLIAKATAKEAG-----CRFINLQPSTLTDKWYGESQKLAAAVFSLAIKL 184

Query: 524 RPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDS--RGEIVVIGATNRLDSID 581
           +PSIIF DEID     RSS   +  + + +  ++L DGLD+    +++V+GATNR   +D
Sbjct: 185 QPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLD 244

Query: 582 PALRRPGRFDREFLFSLPDKEARKEILKIHTRDWN-PKPLDTFLEELAENCVGYCGADIK 640
            A+ R  R    F  + P  + R+ ILK+  ++ N  + +D  L E+A+   G+ G+D+K
Sbjct: 245 SAIMR--RMPTRFHINQPALKQREAILKLILKNENVDRHVD--LLEVAQETDGFSGSDLK 300

Query: 641 SICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKM 686
            +C +AAL  +R     + +TSE+   +     +  +D   A++KM
Sbjct: 301 EMCRDAALLCVRE---YVNSTSEESHDEDEIRPVQQQDLHRAIEKM 343


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score =  141 bits (356), Expect = 4e-33
 Identities = 88/234 (37%), Positives = 128/234 (54%), Gaps = 10/234 (4%)

Query: 422 SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALA 481
           +V++  V GL     ALKE V+ P+ +P +F   K  P RG L +GPPGTGK+ +A+A+A
Sbjct: 130 NVKWSDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWRGILLFGPPGTGKSYLAKAVA 188

Query: 482 NECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRS 541
            E +       FF    +D +SKW+GESE+ ++ LF  A + +PSIIF DEID L   RS
Sbjct: 189 TEANNS----TFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRS 244

Query: 542 SRQDQIHSSIVSTLLALMD--GLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLP 599
             + +    I +  L  M   G+D+ G I+V+GATN    +D A+RR  RF++     LP
Sbjct: 245 ENESEAARRIKTEFLVQMQGVGVDNDG-ILVLGATNIPWVLDSAIRR--RFEKRIYIPLP 301

Query: 600 DKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRR 653
           +  AR  + K+H         +    EL     GY GADI  I  +A +  +R+
Sbjct: 302 EPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRK 355


>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
          Length = 797

 Score =  141 bits (355), Expect = 5e-33
 Identities = 99/290 (34%), Positives = 146/290 (50%), Gaps = 36/290 (12%)

Query: 407 IGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFY 466
           +G + A V   ++D  V+F  V G       + E V F L  P+ ++    + P+G +  
Sbjct: 291 VGETTAKVLKDEID--VKFKDVAGCEEAKLEIMEFVNF-LKNPKQYQDLGAKIPKGAILT 347

Query: 467 GPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPS 526
           GPPGTGKTL+A+A A     G+  V F    G++ L  +VG    ++R LF  A +  P 
Sbjct: 348 GPPGTGKTLLAKATA-----GEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPC 402

Query: 527 IIFFDEIDGLAPVRSSRQ---DQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPA 583
           I+F DEID +   R            + ++ LL  MDG ++   +V++  TNR D +DPA
Sbjct: 403 ILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPA 462

Query: 584 LRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLE------ELAENCVGYCGA 637
           L RPGRFDR+     PD + R  I K+H R   P  LD+ LE      +LA    G+ GA
Sbjct: 463 LLRPGRFDRQIFIGPPDIKGRASIFKVHLR---PLKLDSTLEKDKLARKLASLTPGFSGA 519

Query: 638 DIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMI 687
           D+ ++C EAAL A R                  S +I+ K FE A++++I
Sbjct: 520 DVANVCNEAALIAARH----------------LSDSINQKHFEQAIERVI 553


>gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  138 bits (347), Expect = 4e-32
 Identities = 89/283 (31%), Positives = 140/283 (49%), Gaps = 33/283 (11%)

Query: 401 YKDRMKIGASLADVDPMQLDSSVR------FDSVGGLSNHIAALKEMVVFPLLYPEVFEK 454
           +K    IG  + D  P+     V       + + GGL N I  +KE +  PL +PE +E+
Sbjct: 141 HKVHAVIGVLMDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESMELPLPHPEYYEE 200

Query: 455 FKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLR 514
              +PP+G +  GPPGT                     F    G++ + K++G+  + +R
Sbjct: 201 MGTKPPKGVILCGPPGTA-------------------TFLRVVGSELIQKYLGDGPKLVR 241

Query: 515 LLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL-----MDGLDSRGEIV 569
            +F  A +  PSI+F DEI+ +   R          I  T+L L     + G DSR ++ 
Sbjct: 242 QVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGFDSREDVK 301

Query: 570 VIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAE 629
           VI AT +++++DP L RPGR D++  F LPD++ +K I +IHT        D  L++L  
Sbjct: 302 VIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMT-LANDVTLDDLIM 360

Query: 630 NCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSI 672
               + GADIK+IC EA L ALR    ++  T+E  +  + S+
Sbjct: 361 AKDDFSGADIKAICTEAGLMALREH--RMKATNEDFKKSIESV 401


>gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  138 bits (347), Expect = 4e-32
 Identities = 89/283 (31%), Positives = 140/283 (49%), Gaps = 33/283 (11%)

Query: 401 YKDRMKIGASLADVDPMQLDSSVR------FDSVGGLSNHIAALKEMVVFPLLYPEVFEK 454
           +K    IG  + D  P+     V       + + GGL N I  +KE +  PL +PE +E+
Sbjct: 141 HKVHAVIGVLMDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESMELPLPHPEYYEE 200

Query: 455 FKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLR 514
              +PP+G +  GPPGT                     F    G++ + K++G+  + +R
Sbjct: 201 MGTKPPKGVILCGPPGTA-------------------TFLRVVGSELIQKYLGDGPKLVR 241

Query: 515 LLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL-----MDGLDSRGEIV 569
            +F  A +  PSI+F DEI+ +   R          I  T+L L     + G DSR ++ 
Sbjct: 242 QVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGFDSREDVK 301

Query: 570 VIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAE 629
           VI AT +++++DP L RPGR D++  F LPD++ +K I +IHT        D  L++L  
Sbjct: 302 VIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMT-LANDVTLDDLIM 360

Query: 630 NCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSI 672
               + GADIK+IC EA L ALR    ++  T+E  +  + S+
Sbjct: 361 AKDDFSGADIKAICTEAGLMALREH--RMKATNEDFKKSIESV 401


>gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo
           sapiens]
          Length = 415

 Score =  138 bits (347), Expect = 4e-32
 Identities = 89/283 (31%), Positives = 140/283 (49%), Gaps = 33/283 (11%)

Query: 401 YKDRMKIGASLADVDPMQLDSSVR------FDSVGGLSNHIAALKEMVVFPLLYPEVFEK 454
           +K    IG  + D  P+     V       + + GGL N I  +KE +  PL +PE +E+
Sbjct: 141 HKVHAVIGVLMDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESMELPLPHPEYYEE 200

Query: 455 FKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLR 514
              +PP+G +  GPPGT                     F    G++ + K++G+  + +R
Sbjct: 201 MGTKPPKGVILCGPPGTA-------------------TFLRVVGSELIQKYLGDGPKLVR 241

Query: 515 LLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL-----MDGLDSRGEIV 569
            +F  A +  PSI+F DEI+ +   R          I  T+L L     + G DSR ++ 
Sbjct: 242 QVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGFDSREDVK 301

Query: 570 VIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAE 629
           VI AT +++++DP L RPGR D++  F LPD++ +K I +IHT        D  L++L  
Sbjct: 302 VIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMT-LANDVTLDDLIM 360

Query: 630 NCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSI 672
               + GADIK+IC EA L ALR    ++  T+E  +  + S+
Sbjct: 361 AKDDFSGADIKAICTEAGLMALREH--RMKATNEDFKKSIESV 401


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  137 bits (346), Expect = 5e-32
 Identities = 91/268 (33%), Positives = 141/268 (52%), Gaps = 14/268 (5%)

Query: 421 SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL 480
           ++V+FD + G      AL+E+V+ P L PE+F   +  P RG L +GPPG GKT++A+A+
Sbjct: 305 TAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTMLAKAV 363

Query: 481 ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR 540
           A E +       FF    A   SK+VGE E+ +R LF  A +++PSIIF DE+D L   R
Sbjct: 364 AAESN-----ATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCER 418

Query: 541 SSRQDQIHSSIVSTLLALMDGLDSRGE--IVVIGATNRLDSIDPALRRPGRFDREFLFSL 598
              +      + +  L   DG+ S G+  ++V+GATNR   +D A+ R  RF +    SL
Sbjct: 419 REGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSL 476

Query: 599 PDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQI 658
           P++E R  +LK              L +LA    GY G+D+ ++  +AAL  +R   P+ 
Sbjct: 477 PNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQ 536

Query: 659 YTTSEKLQLDLSSINISAKDFEVAMQKM 686
                  ++     NI   DF  +++K+
Sbjct: 537 VKNMSASEMR----NIRLSDFTESLKKI 560



 Score = 33.5 bits (75), Expect = 1.5
 Identities = 37/165 (22%), Positives = 71/165 (43%), Gaps = 18/165 (10%)

Query: 795 ILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAP 854
           +L+ G PG G+ + LA AV  A    T + +    L        E+    +   A+   P
Sbjct: 346 LLLFGPPGNGK-TMLAKAVA-AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQP 403

Query: 855 SIVYVPHIHVWW-------EIVGPTLKATFTTLLQNIPSFAP--VLLLATSDKPHSALPE 905
           SI+++  +                 LK  F      + S     VL++  +++P     +
Sbjct: 404 SIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRP-----Q 458

Query: 906 EVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKK 950
           E+ E  +R + +   V LP++E R    ++L+ KQ +  P+++K+
Sbjct: 459 ELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGS--PLTQKE 501


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score =  137 bits (346), Expect = 5e-32
 Identities = 91/268 (33%), Positives = 141/268 (52%), Gaps = 14/268 (5%)

Query: 421 SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL 480
           ++V+FD + G      AL+E+V+ P L PE+F   +  P RG L +GPPG GKT++A+A+
Sbjct: 337 TAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTMLAKAV 395

Query: 481 ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR 540
           A E +       FF    A   SK+VGE E+ +R LF  A +++PSIIF DE+D L   R
Sbjct: 396 AAESN-----ATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCER 450

Query: 541 SSRQDQIHSSIVSTLLALMDGLDSRGE--IVVIGATNRLDSIDPALRRPGRFDREFLFSL 598
              +      + +  L   DG+ S G+  ++V+GATNR   +D A+ R  RF +    SL
Sbjct: 451 REGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSL 508

Query: 599 PDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQI 658
           P++E R  +LK              L +LA    GY G+D+ ++  +AAL  +R   P+ 
Sbjct: 509 PNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQ 568

Query: 659 YTTSEKLQLDLSSINISAKDFEVAMQKM 686
                  ++     NI   DF  +++K+
Sbjct: 569 VKNMSASEMR----NIRLSDFTESLKKI 592



 Score = 33.5 bits (75), Expect = 1.5
 Identities = 37/165 (22%), Positives = 71/165 (43%), Gaps = 18/165 (10%)

Query: 795 ILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAP 854
           +L+ G PG G+ + LA AV  A    T + +    L        E+    +   A+   P
Sbjct: 378 LLLFGPPGNGK-TMLAKAVA-AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQP 435

Query: 855 SIVYVPHIHVWW-------EIVGPTLKATFTTLLQNIPSFAP--VLLLATSDKPHSALPE 905
           SI+++  +                 LK  F      + S     VL++  +++P     +
Sbjct: 436 SIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRP-----Q 490

Query: 906 EVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKK 950
           E+ E  +R + +   V LP++E R    ++L+ KQ +  P+++K+
Sbjct: 491 ELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGS--PLTQKE 533


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  135 bits (341), Expect = 2e-31
 Identities = 80/232 (34%), Positives = 125/232 (53%), Gaps = 10/232 (4%)

Query: 423 VRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 482
           V ++ + G+    A +KE+VV+P+L P++F   +  PP+G L +GPPGTGKTL+ + +A+
Sbjct: 398 VNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTGKTLIGKCIAS 456

Query: 483 ECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSS 542
           +         FF    +   SKWVGE E+ +R LF  A   +P++IF DEID L   R  
Sbjct: 457 QSG-----ATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGD 511

Query: 543 RQDQIHSSIVSTLLALMDGLDSRGE--IVVIGATNRLDSIDPALRRPGRFDREFLFSLPD 600
            + +    I +  L  +DG  +  E  I+V+GATNR   ID A RR  R  +     LP+
Sbjct: 512 GEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPE 569

Query: 601 KEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALR 652
             ARK+I+            +  +E++ +    + GAD+  +C EA+L  +R
Sbjct: 570 ASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIR 621


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,805,395
Number of Sequences: 37866
Number of extensions: 2628698
Number of successful extensions: 48718
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 771
Number of HSP's successfully gapped in prelim test: 408
Number of HSP's that attempted gapping in prelim test: 19848
Number of HSP's gapped (non-prelim): 11936
length of query: 1390
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1275
effective length of database: 13,892,928
effective search space: 17713483200
effective search space used: 17713483200
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.