Search of human proteins with 11875211

Search of human proteins with 11875211

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11875211 spastin isoform 1 [Homo sapiens]
         (616 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11875211 spastin isoform 1 [Homo sapiens]                         1216   0.0  
gi|40806170 spastin isoform 2 [Homo sapiens]                         1134   0.0  
gi|31742536 fidgetin-like 1 [Homo sapiens]                            336   3e-92
gi|112789543 fidgetin-like 1 [Homo sapiens]                           336   3e-92
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     246   3e-65
gi|64084766 fidgetin [Homo sapiens]                                   242   8e-64
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               240   3e-63
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               240   3e-63
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]         236   4e-62
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]          227   3e-59
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]              215   8e-56
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     192   8e-49
gi|116292174 fidgetin-like 2 [Homo sapiens]                           180   4e-45
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              178   1e-44
gi|6005942 valosin-containing protein [Homo sapiens]                  158   2e-38
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 149   6e-36
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 149   6e-36
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            145   1e-34
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           144   2e-34
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            142   7e-34
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            142   1e-33
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     137   2e-32
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   136   5e-32
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   136   5e-32
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   136   5e-32
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   136   5e-32
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           135   1e-31
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       132   7e-31
gi|4505725 peroxin1 [Homo sapiens]                                    132   7e-31
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]            131   2e-30

>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score = 1216 bits (3147), Expect = 0.0
 Identities = 616/616 (100%), Positives = 616/616 (100%)

Query: 1   MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG 60
           MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
Sbjct: 1   MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG 60

Query: 61  FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH 120
           FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
Sbjct: 61  FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH 120

Query: 121 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK 180
           KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
Sbjct: 121 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK 180

Query: 181 MMTNLVMAKDRLQLLEKMQPVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLT 240
           MMTNLVMAKDRLQLLEKMQPVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLT
Sbjct: 181 MMTNLVMAKDRLQLLEKMQPVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLT 240

Query: 241 HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK 300
           HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK
Sbjct: 241 HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK 300

Query: 301 PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL 360
           PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL
Sbjct: 301 PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL 360

Query: 361 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 420
           PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE
Sbjct: 361 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 420

Query: 421 KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV 480
           KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV
Sbjct: 421 KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV 480

Query: 481 LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM 540
           LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM
Sbjct: 481 LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM 540

Query: 541 TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT 600
           TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT
Sbjct: 541 TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT 600

Query: 601 LEAYIRWNKDFGDTTV 616
           LEAYIRWNKDFGDTTV
Sbjct: 601 LEAYIRWNKDFGDTTV 616


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score = 1134 bits (2934), Expect = 0.0
 Identities = 584/616 (94%), Positives = 584/616 (94%), Gaps = 32/616 (5%)

Query: 1   MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG 60
           MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
Sbjct: 1   MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG 60

Query: 61  FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH 120
           FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
Sbjct: 61  FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH 120

Query: 121 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK 180
           KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
Sbjct: 121 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK 180

Query: 181 MMTNLVMAKDRLQLLEKMQPVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLT 240
           MMTNLVMAKDRLQLL                                ESGAVPKRKDPLT
Sbjct: 181 MMTNLVMAKDRLQLL--------------------------------ESGAVPKRKDPLT 208

Query: 241 HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK 300
           HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK
Sbjct: 209 HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK 268

Query: 301 PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL 360
           PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL
Sbjct: 269 PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL 328

Query: 361 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 420
           PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE
Sbjct: 329 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 388

Query: 421 KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV 480
           KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV
Sbjct: 389 KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV 448

Query: 481 LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM 540
           LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM
Sbjct: 449 LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM 508

Query: 541 TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT 600
           TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT
Sbjct: 509 TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT 568

Query: 601 LEAYIRWNKDFGDTTV 616
           LEAYIRWNKDFGDTTV
Sbjct: 569 LEAYIRWNKDFGDTTV 584


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  336 bits (862), Expect = 3e-92
 Identities = 174/397 (43%), Positives = 254/397 (63%), Gaps = 17/397 (4%)

Query: 231 AVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSG------- 283
           A  K +D      +SLP  KT  +         +  P  +  S   GVK+  G       
Sbjct: 277 ACSKTEDNGPKEDSSLPTFKTAKEQLWVDQQKKYHQPQRASGSSYGGVKKSLGASRSRGI 336

Query: 284 ------PAPTTHKGTPKTNRTNKP--STPTTATRKKKDLKNFRNVDSNLANLIMNEIVDN 335
                 P P    G        KP  + PT       +    +N++  +  LIMNEI+D+
Sbjct: 337 LGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDE--RLKNLEPKMIELIMNEIMDH 394

Query: 336 GTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAV 395
           G  V ++DIAG + AK  ++EIV+ P LRP++FTGLR P +G+LLFGPPG GKT++ K +
Sbjct: 395 GPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCI 454

Query: 396 AAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEH 455
           A++S ATFF+ISA+SLTSK+VGEGEK+VRALFAVAR  QP++IFIDE+DSLL +R +GEH
Sbjct: 455 ASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEH 514

Query: 456 DASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRL 515
           ++SRR+KTEFL++ DG  ++ +DR+LV+GATNRPQE+DEA  RR +KR+Y+ LP    R 
Sbjct: 515 ESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARK 574

Query: 516 LLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSAS 575
            ++ NL+ K+   L+++E+ Q+ + +D +SG+D+T L ++A+LGPIR L+   +  ++  
Sbjct: 575 QIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPD 634

Query: 576 EMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 612
           ++R I   DF  + + ++ SVSP+ LE Y  WNK FG
Sbjct: 635 QVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFG 671


>gi|112789543 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  336 bits (862), Expect = 3e-92
 Identities = 174/397 (43%), Positives = 254/397 (63%), Gaps = 17/397 (4%)

Query: 231 AVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSG------- 283
           A  K +D      +SLP  KT  +         +  P  +  S   GVK+  G       
Sbjct: 277 ACSKTEDNGPKEDSSLPTFKTAKEQLWVDQQKKYHQPQRASGSSYGGVKKSLGASRSRGI 336

Query: 284 ------PAPTTHKGTPKTNRTNKP--STPTTATRKKKDLKNFRNVDSNLANLIMNEIVDN 335
                 P P    G        KP  + PT       +    +N++  +  LIMNEI+D+
Sbjct: 337 LGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDE--RLKNLEPKMIELIMNEIMDH 394

Query: 336 GTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAV 395
           G  V ++DIAG + AK  ++EIV+ P LRP++FTGLR P +G+LLFGPPG GKT++ K +
Sbjct: 395 GPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCI 454

Query: 396 AAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEH 455
           A++S ATFF+ISA+SLTSK+VGEGEK+VRALFAVAR  QP++IFIDE+DSLL +R +GEH
Sbjct: 455 ASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEH 514

Query: 456 DASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRL 515
           ++SRR+KTEFL++ DG  ++ +DR+LV+GATNRPQE+DEA  RR +KR+Y+ LP    R 
Sbjct: 515 ESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARK 574

Query: 516 LLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSAS 575
            ++ NL+ K+   L+++E+ Q+ + +D +SG+D+T L ++A+LGPIR L+   +  ++  
Sbjct: 575 QIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPD 634

Query: 576 EMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 612
           ++R I   DF  + + ++ SVSP+ LE Y  WNK FG
Sbjct: 635 QVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFG 671


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  246 bits (629), Expect = 3e-65
 Identities = 158/415 (38%), Positives = 227/415 (54%), Gaps = 20/415 (4%)

Query: 214 DSTNLACRNGHLQSESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYS--- 270
           DST L      L +  G V     P+    +  PR +   +        H   PS +   
Sbjct: 79  DSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDP--KSHGNRPSTTVRV 136

Query: 271 GLSMVSGVKQGSGPAPTTH-KGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIM 329
             S    V    G A     K      R  K  +P   T  + +  +    D +L   + 
Sbjct: 137 HRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALE 196

Query: 330 NEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKT 389
            +I+     V++DDIA    AK+ L+E V+LP   PE F G+R P +G+L+ GPPG GKT
Sbjct: 197 RDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKT 256

Query: 390 MLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCE 449
           +LAKAVA E   TFFN+S+++LTSKY GE EKLVR LF +AR   P+ IFIDE+DS +C 
Sbjct: 257 LLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDS-ICS 315

Query: 450 RR--EGEHDASRRLKTEFLIEFDGV--QSAGDD---RVLVMGATNRPQELDEAVLRRFIK 502
           RR    EH+ASRR+K E L++ DGV   S  DD    V+V+ ATN P ++DEA+ RR  K
Sbjct: 316 RRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEK 375

Query: 503 RVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR 562
           R+Y+ LP+ + R  LL+ +  ++       +LA +A   +GYSG+D+T + +DA+L  +R
Sbjct: 376 RIYIPLPSAKGREELLR-ISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMR 434

Query: 563 E----LKPEQVKNMSASEMR-NIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 612
                L PE+++N+S  EM     + DF  +LKK+ +SVS   +E Y +W  +FG
Sbjct: 435 RRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFG 489


>gi|64084766 fidgetin [Homo sapiens]
          Length = 759

 Score =  242 bits (617), Expect = 8e-64
 Identities = 116/298 (38%), Positives = 192/298 (64%)

Query: 315 KNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAP 374
           +  +N D++L +L+ NEI+  G  V ++DIAG DL K  ++E V+ P LR + F+GL A 
Sbjct: 459 EQLKNTDTHLIDLVTNEIITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTAL 518

Query: 375 ARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQ 434
            R +LLFGP G GKT+L + +A++  ATFF I+ + L +K++GE EK++ A F VAR  Q
Sbjct: 519 PRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQ 578

Query: 435 PSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDE 494
           PS+IF+ ++D LL  +   EH    R++TEFL++ D V ++ +D+++V+ AT++P+E+DE
Sbjct: 579 PSVIFVSDIDMLLSSQVNEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDE 638

Query: 495 AVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAK 554
           ++ R F+KR+ + LP+   R  ++  LL +    L  KE A L + T+G+SG D+  L +
Sbjct: 639 SLRRYFMKRLLIPLPDSTARHQIIVQLLSQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQ 698

Query: 555 DAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 612
           +A +GP+  +    +  +  S++R +   DF  +  KI+ S+S + L+ Y+ WNK FG
Sbjct: 699 EAVVGPLHAMPATDLSAIMPSQLRPVTYQDFENAFCKIQPSISQKELDMYVEWNKMFG 756


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  240 bits (612), Expect = 3e-63
 Identities = 141/305 (46%), Positives = 196/305 (64%), Gaps = 16/305 (5%)

Query: 321 DSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLL 380
           D +L   +  +IV    ++ +DDIA  + AK+ L+E V+LP   P+ F G+R P +G+L+
Sbjct: 187 DKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLM 246

Query: 381 FGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFI 440
            GPPG GKTMLAKAVA E   TFFN+S+++LTSKY GE EKLVR LF +AR   P+ IFI
Sbjct: 247 VGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFI 306

Query: 441 DEVDSLLCERR--EGEHDASRRLKTEFLIEFDGVQSA--GDD---RVLVMGATNRPQELD 493
           DE+DS +C RR    EH+ASRR+K+E LI+ DGV  A   DD    V+V+ ATN P ++D
Sbjct: 307 DEIDS-ICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365

Query: 494 EAVLRRFIKRVYVSLPNEETRLLLLK-NLLCKQGSPLTQKELAQLARMTDGYSGSDLTAL 552
           EA+ RR  KR+Y+ LP  + R  LLK NL   +  P  Q  L  +A   +GYSG+D+T +
Sbjct: 366 EALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQ--LEDIAEKIEGYSGADITNV 423

Query: 553 AKDAALGPIRE----LKPEQVKNMSASEMR-NIRLSDFTESLKKIKRSVSPQTLEAYIRW 607
            +DA+L  +R     L PE+++ +S  E++  +   DF  +LKKI +SVS   LE Y +W
Sbjct: 424 CRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKW 483

Query: 608 NKDFG 612
             +FG
Sbjct: 484 MVEFG 488


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  240 bits (612), Expect = 3e-63
 Identities = 141/305 (46%), Positives = 196/305 (64%), Gaps = 16/305 (5%)

Query: 321 DSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLL 380
           D +L   +  +IV    ++ +DDIA  + AK+ L+E V+LP   P+ F G+R P +G+L+
Sbjct: 187 DKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLM 246

Query: 381 FGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFI 440
            GPPG GKTMLAKAVA E   TFFN+S+++LTSKY GE EKLVR LF +AR   P+ IFI
Sbjct: 247 VGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFI 306

Query: 441 DEVDSLLCERR--EGEHDASRRLKTEFLIEFDGVQSA--GDD---RVLVMGATNRPQELD 493
           DE+DS +C RR    EH+ASRR+K+E LI+ DGV  A   DD    V+V+ ATN P ++D
Sbjct: 307 DEIDS-ICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365

Query: 494 EAVLRRFIKRVYVSLPNEETRLLLLK-NLLCKQGSPLTQKELAQLARMTDGYSGSDLTAL 552
           EA+ RR  KR+Y+ LP  + R  LLK NL   +  P  Q  L  +A   +GYSG+D+T +
Sbjct: 366 EALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQ--LEDIAEKIEGYSGADITNV 423

Query: 553 AKDAALGPIRE----LKPEQVKNMSASEMR-NIRLSDFTESLKKIKRSVSPQTLEAYIRW 607
            +DA+L  +R     L PE+++ +S  E++  +   DF  +LKKI +SVS   LE Y +W
Sbjct: 424 CRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKW 483

Query: 608 NKDFG 612
             +FG
Sbjct: 484 MVEFG 488


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score =  236 bits (603), Expect = 4e-62
 Identities = 134/293 (45%), Positives = 184/293 (62%), Gaps = 13/293 (4%)

Query: 294 KTNRTNKPSTPTTATRKKKDLKNFRNVDS----NLANLIMNEIVDNGTAVKFDDIAGQDL 349
           K  +  K   P+ A  K  D       D      L N +   IV     VK+ D+AG + 
Sbjct: 82  KAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEG 141

Query: 350 AKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESN-ATFFNISA 408
           AK+AL+E VILP   P LFTG R P RG+LLFGPPG GK+ LAKAVA E+N +TFF+IS+
Sbjct: 142 AKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISS 201

Query: 409 ASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIE 468
           + L SK++GE EKLV+ LF +ARE +PSIIFIDE+DSL   R E E +A+RR+KTEFL++
Sbjct: 202 SDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQ 261

Query: 469 FDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSP 528
             GV    +D +LV+GATN P  LD A+ RRF KR+Y+ LP    R  + K  L    + 
Sbjct: 262 MQGV-GVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHLGTTQNS 320

Query: 529 LTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIR 581
           LT+ +  +L R TDGYSG+D++ + +DA + P+R+++       SA+  + +R
Sbjct: 321 LTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQ-------SATHFKKVR 366


>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
          Length = 437

 Score =  227 bits (578), Expect = 3e-59
 Identities = 119/243 (48%), Positives = 170/243 (69%), Gaps = 2/243 (0%)

Query: 324 LANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGP 383
           L   +M  +V     ++++D+AG + AK+AL+E VILP   P LFTG R P RG+LLFGP
Sbjct: 109 LQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGP 168

Query: 384 PGNGKTMLAKAVAAESN-ATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDE 442
           PG GK+ LAKAVA E+N +TFF++S++ L SK++GE EKLV+ LF +AR+ +PSIIFIDE
Sbjct: 169 PGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDE 228

Query: 443 VDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIK 502
           VDSL   R E E +A+RR+KTEFL++  GV +  +D  LV+GATN P  LD A+ RRF K
Sbjct: 229 VDSLCGSRNENESEAARRIKTEFLVQMQGVGN-NNDGTLVLGATNIPWVLDSAIRRRFEK 287

Query: 503 RVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR 562
           R+Y+ LP E  R  + +  L      LT   + +LAR T+GYSG+D++ + +D+ + P+R
Sbjct: 288 RIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVR 347

Query: 563 ELK 565
           +++
Sbjct: 348 KVQ 350


>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score =  215 bits (548), Expect = 8e-56
 Identities = 129/325 (39%), Positives = 199/325 (61%), Gaps = 19/325 (5%)

Query: 304 PTTATRKKKDLKNFRNVDSN---LANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL 360
           P  + R  K L  F  ++S    LA ++  +I  +   +K++DI G D AKQ ++E V+ 
Sbjct: 141 PDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVY 200

Query: 361 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 420
           P   P+LFTG+ +P +GLLL+GPPG GKT+LAKAVA E   TFFNISA+++ SK+ G+ E
Sbjct: 201 PIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSE 260

Query: 421 KLVRALFAVARELQPSIIFIDEVDSLLCER---REGEHDASRRLKTEFLIEFDGVQSAGD 477
           KLVR LF +AR   PS IF+DE++S++ +R     GEH+ S R+KTE L++ DG+ +  +
Sbjct: 261 KLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGL-ARSE 319

Query: 478 DRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPL-----TQK 532
           D V V+ A+N P ELD A+LRR  KR+ V LP+ E R  ++ + L            T+ 
Sbjct: 320 DLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTEL 379

Query: 533 ELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMS-ASEMRNIRL-----SDFT 586
           E + L++ T+GYSGSD+  + ++AA+ P+R++      + S +S++  I+L     +DF 
Sbjct: 380 EYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFL 439

Query: 587 ESLKKIKRSVSPQTLEAYIRWNKDF 611
           + L   K S +    + Y  W ++F
Sbjct: 440 DVLTHTKPS-AKNLAQRYSDWQREF 463


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  192 bits (488), Expect = 8e-49
 Identities = 106/260 (40%), Positives = 166/260 (63%), Gaps = 4/260 (1%)

Query: 339 VKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA--PARGLLLFGPPGNGKTMLAKAVA 396
           V + DIAG D     L++ VILP  +  LF   R   P +G+LL+GPPG GKT++AKA A
Sbjct: 88  VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATA 147

Query: 397 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 456
            E+   F N+  ++LT K+ GE +KL  A+F++A +LQPSIIFIDE+DS L  R   +H+
Sbjct: 148 KEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHE 207

Query: 457 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLL 516
           A+  +K +F+  +DG+ +    +V+VMGATNRPQ+LD A++RR   R +++ P  + R  
Sbjct: 208 ATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREA 267

Query: 517 LLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRE-LKPEQVKNMSAS 575
           +LK L+ K  +     +L ++A+ TDG+SGSDL  + +DAAL  +RE +     ++    
Sbjct: 268 ILK-LILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDED 326

Query: 576 EMRNIRLSDFTESLKKIKRS 595
           E+R ++  D   +++K+K+S
Sbjct: 327 EIRPVQQQDLHRAIEKMKKS 346


>gi|116292174 fidgetin-like 2 [Homo sapiens]
          Length = 653

 Score =  180 bits (456), Expect = 4e-45
 Identities = 107/295 (36%), Positives = 161/295 (54%), Gaps = 12/295 (4%)

Query: 318 RNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARG 377
           + VD     L+ +++VD G  V++ D+AGQ   K AL+E ++ P LRP  + G   P R 
Sbjct: 368 KGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRT 427

Query: 378 LLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSI 437
           +LLFGP G GK +L + +A +  AT   +  A+L +    EG +L++A FA AR   PS+
Sbjct: 428 VLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSV 487

Query: 438 IFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVL 497
           + I E+++LL  R +G   A   L+   L   DG   AG D VLV+G T+RP  LDEA  
Sbjct: 488 LLISELEALLPARDDGA-AAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATR 546

Query: 498 RRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAA 557
           RRF  R YV+LP+   R  +L+  L +QG  L+++ELA L + T G+SG +L  L + AA
Sbjct: 547 RRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAA 606

Query: 558 LGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 612
            G                  R +   D   +L K+    S + L++++ W+K +G
Sbjct: 607 AGA-----------GLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYG 650



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 18/44 (40%), Positives = 19/44 (43%)

Query: 2   NSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESP 45
           N P G    +   GA  P P  PP P L P  PA  P P P  P
Sbjct: 204 NYPAGGYAAQPGYGALPPPPGPPPAPYLTPGLPAPTPLPAPAPP 247


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  178 bits (452), Expect = 1e-44
 Identities = 114/287 (39%), Positives = 166/287 (57%), Gaps = 14/287 (4%)

Query: 316 NFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPA 375
           NF  +D N      ++  DN   V +D I G     +A++EI+ LP  +PELF     PA
Sbjct: 333 NFTEIDKN------SKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPA 386

Query: 376 -RGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQ 434
            RG+LL+GPPG GKTM+A+AVA E  A    I+   + SK+ GE E  +R +FA A    
Sbjct: 387 PRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRH 446

Query: 435 PSIIFIDEVDSLLCERREG-EHDASRRLKTEFLIEFDGVQS-AGDDRVLVMGATNRPQEL 492
           PSIIFIDE+D+ LC +REG +++  +R+    L   DG+ S   + +VLV+GATNRP  L
Sbjct: 447 PSIIFIDELDA-LCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHAL 505

Query: 493 DEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLT 550
           D A+ R  RF K + + +PN + RL +L+ LL +    LT+ EL QLA    GY G+DL 
Sbjct: 506 DAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLK 565

Query: 551 ALAKDAALGPIREL--KPEQVKNMSASEMRNIRLSDFTESLKKIKRS 595
            L  +A L  +R +  K   + ++  + +  I L DF +++  I+ S
Sbjct: 566 VLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPS 612



 Score =  153 bits (387), Expect = 4e-37
 Identities = 107/307 (34%), Positives = 165/307 (53%), Gaps = 24/307 (7%)

Query: 311 KKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTG 370
           K  LK+F    +++    M EI  +   V + DI G +  K  L++ V  P   PE F  
Sbjct: 596 KITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIR 655

Query: 371 LRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAV 429
           +   P +G+LL+GPPG  KTM+AKA+A ES   F  I    L +KYVGE E+ VR  F  
Sbjct: 656 MGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRK 715

Query: 430 ARELQPSIIFIDEVDSLLCERRE--GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATN 487
           AR + PSIIF DE+D+L  ER    G  + + R+  + L E DG++   D  V ++ ATN
Sbjct: 716 ARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKD--VTILAATN 773

Query: 488 RPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK-ELAQLARMTDGY 544
           RP  +D+A++R  R  + +YV LP+  TR  + K  L     P++ + +L +L   TD Y
Sbjct: 774 RPDRIDKALMRPGRIDRIIYVPLPDAATRREIFK--LQFHSMPVSNEVDLDELILQTDAY 831

Query: 545 SGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAY 604
           SG+++ A+ ++AAL  + E            +   I    FT++L     +V+P+  E+ 
Sbjct: 832 SGAEIVAVCREAALLALEE----------DIQANLIMKRHFTQALS----TVTPRIPESL 877

Query: 605 IRWNKDF 611
            R+ +D+
Sbjct: 878 RRFYEDY 884


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  158 bits (399), Expect = 2e-38
 Identities = 107/296 (36%), Positives = 164/296 (55%), Gaps = 24/296 (8%)

Query: 329 MNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGL-RAPARGLLLFGPPGNG 387
           + E V     V ++DI G +  K+ LQE+V  P   P+ F      P++G+L +GPPG G
Sbjct: 464 LRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCG 523

Query: 388 KTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLL 447
           KT+LAKA+A E  A F +I    L + + GE E  VR +F  AR+  P ++F DE+DS+ 
Sbjct: 524 KTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIA 583

Query: 448 CERREGEHD---ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIK 502
             R     D   A+ R+  + L E DG+ +     V ++GATNRP  +D A+LR  R  +
Sbjct: 584 KARGGNIGDGGGAADRVINQILTEMDGMST--KKNVFIIGATNRPDIIDPAILRPGRLDQ 641

Query: 503 RVYVSLPNEETRLLLLKNLLCKQGSPLTQK-ELAQLARMTDGYSGSDLTALAKDAALGPI 561
            +Y+ LP+E++R+ +LK  L K  SP+ +  +L  LA+MT+G+SG+DLT + + A    I
Sbjct: 642 LIYIPLPDEKSRVAILKANLRK--SPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAI 699

Query: 562 RELKPEQVK-------NMSASEMR------NIRLSDFTESLKKIKRSVSPQTLEAY 604
           RE    +++       N SA E+        IR   F E+++  +RSVS   +  Y
Sbjct: 700 RESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKY 755



 Score =  146 bits (368), Expect = 6e-35
 Identities = 97/271 (35%), Positives = 150/271 (55%), Gaps = 11/271 (4%)

Query: 339 VKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAA 397
           V +DDI G       ++E+V LP   P LF  +   P RG+LL+GPPG GKT++A+AVA 
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260

Query: 398 ESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDA 457
           E+ A FF I+   + SK  GE E  +R  F  A +  P+IIFIDE+D++  +R +   + 
Sbjct: 261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEV 320

Query: 458 SRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRL 515
            RR+ ++ L   DG++      V+VM ATNRP  +D A+ R  RF + V + +P+   RL
Sbjct: 321 ERRIVSQLLTLMDGLKQRA--HVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRL 378

Query: 516 LLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR---ELKPEQVKNM 572
            +L+ +  K        +L Q+A  T G+ G+DL AL  +AAL  IR   +L   + + +
Sbjct: 379 EILQ-IHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETI 437

Query: 573 SASEMRN--IRLSDFTESLKKIKRSVSPQTL 601
            A  M +  + + DF  +L +   S   +T+
Sbjct: 438 DAEVMNSLAVTMDDFRWALSQSNPSALRETV 468


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  149 bits (377), Expect = 6e-36
 Identities = 100/278 (35%), Positives = 152/278 (54%), Gaps = 16/278 (5%)

Query: 339 VKFDDIAGQDLAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 396
           V + DI   +  ++ L   ++ P   P+ F   GL  PA G+LL GPPG GKT+LAKAVA
Sbjct: 472 VTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPA-GVLLAGPPGCGKTLLAKAVA 530

Query: 397 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 456
            ES   F ++    L + YVGE E+ VR +F  A+   P +IF DEVD+L   R + E  
Sbjct: 531 NESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG 590

Query: 457 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETR 514
           AS R+  + L E DG+++    +V +M ATNRP  +D A+LR  R  K ++V LP    R
Sbjct: 591 ASVRVVNQLLTEMDGLEAR--QQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADR 648

Query: 515 LLLLKNLLCKQGSPLTQKELAQLA----RMTDGYSGSDLTALAKDAALGPIRELKPEQVK 570
           L +LK +      P    ++   A       D Y+G+DL+AL ++A++  +R+   E  +
Sbjct: 649 LAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ---EMAR 705

Query: 571 NMSASEMRNIRLS--DFTESLKKIKRSVSPQTLEAYIR 606
             S +E   +++S   F E+ KK++ S+S +    Y R
Sbjct: 706 QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 743



 Score =  142 bits (359), Expect = 7e-34
 Identities = 97/282 (34%), Positives = 154/282 (54%), Gaps = 18/282 (6%)

Query: 309 RKKKDLKNFRNVDSNLANLIMNEIVDNG-----TAVKFDDIAGQDLAKQALQEIVILPSL 363
           RKK+DL+    VD  +  ++  +    G     + VKF+D+ G D+  + + +++I    
Sbjct: 124 RKKEDLQE---VDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLI-HMR 179

Query: 364 RPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 422
            PE++  L   P RG+LL GPPG GKT+LA A+A E +     ++A  + S   GE E+ 
Sbjct: 180 HPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQK 239

Query: 423 VRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQS-AGDDRVL 481
           +R LF  A    P IIFIDE+D++  +R     D  RR+  + L   D + + A   RVL
Sbjct: 240 LRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVL 299

Query: 482 VMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLAR 539
           V+GATNRP  LD A+ R  RF + + + +P+E +R  +L+ L  K   P    +   LA 
Sbjct: 300 VIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLP-QAFDFCHLAH 358

Query: 540 MTDGYSGSDLTALAKDAALGPIR----ELKPEQVKNMSASEM 577
           +T G+ G+DL AL ++AA+  +     +L+ +Q KN    ++
Sbjct: 359 LTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDL 400


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  149 bits (377), Expect = 6e-36
 Identities = 100/278 (35%), Positives = 152/278 (54%), Gaps = 16/278 (5%)

Query: 339 VKFDDIAGQDLAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 396
           V + DI   +  ++ L   ++ P   P+ F   GL  PA G+LL GPPG GKT+LAKAVA
Sbjct: 578 VTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPA-GVLLAGPPGCGKTLLAKAVA 636

Query: 397 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 456
            ES   F ++    L + YVGE E+ VR +F  A+   P +IF DEVD+L   R + E  
Sbjct: 637 NESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG 696

Query: 457 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETR 514
           AS R+  + L E DG+++    +V +M ATNRP  +D A+LR  R  K ++V LP    R
Sbjct: 697 ASVRVVNQLLTEMDGLEAR--QQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADR 754

Query: 515 LLLLKNLLCKQGSPLTQKELAQLA----RMTDGYSGSDLTALAKDAALGPIRELKPEQVK 570
           L +LK +      P    ++   A       D Y+G+DL+AL ++A++  +R+   E  +
Sbjct: 755 LAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ---EMAR 811

Query: 571 NMSASEMRNIRLS--DFTESLKKIKRSVSPQTLEAYIR 606
             S +E   +++S   F E+ KK++ S+S +    Y R
Sbjct: 812 QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 849



 Score =  142 bits (359), Expect = 7e-34
 Identities = 97/282 (34%), Positives = 154/282 (54%), Gaps = 18/282 (6%)

Query: 309 RKKKDLKNFRNVDSNLANLIMNEIVDNG-----TAVKFDDIAGQDLAKQALQEIVILPSL 363
           RKK+DL+    VD  +  ++  +    G     + VKF+D+ G D+  + + +++I    
Sbjct: 230 RKKEDLQE---VDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLI-HMR 285

Query: 364 RPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 422
            PE++  L   P RG+LL GPPG GKT+LA A+A E +     ++A  + S   GE E+ 
Sbjct: 286 HPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQK 345

Query: 423 VRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQS-AGDDRVL 481
           +R LF  A    P IIFIDE+D++  +R     D  RR+  + L   D + + A   RVL
Sbjct: 346 LRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVL 405

Query: 482 VMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLAR 539
           V+GATNRP  LD A+ R  RF + + + +P+E +R  +L+ L  K   P    +   LA 
Sbjct: 406 VIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLP-QAFDFCHLAH 464

Query: 540 MTDGYSGSDLTALAKDAALGPIR----ELKPEQVKNMSASEM 577
           +T G+ G+DL AL ++AA+  +     +L+ +Q KN    ++
Sbjct: 465 LTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDL 506


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  145 bits (366), Expect = 1e-34
 Identities = 94/247 (38%), Positives = 147/247 (59%), Gaps = 14/247 (5%)

Query: 324 LANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLR-APARGLLLFG 382
           L +L+M E V + T   ++ I G D   + ++E++ LP   PELF  L  A  +G+LL+G
Sbjct: 134 LVSLMMVEKVPDST---YEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYG 190

Query: 383 PPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDE 442
           PPG GKT+LA+AVA  ++ TF  +S + L  K++GEG ++VR LF +ARE  PSIIF+DE
Sbjct: 191 PPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDE 250

Query: 443 VDSLLCERREGEHDAS---RRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR- 498
           +DS+   R EG        +R   E L + DG ++  + +V++  ATNR   LD A+LR 
Sbjct: 251 IDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIM--ATNRIDILDSALLRP 308

Query: 499 -RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK-ELAQLARMTDGYSGSDLTALAKDA 556
            R  +++    PNEE RL +LK  +  +   LT+   L ++A +  G SG+++  +  +A
Sbjct: 309 GRIDRKIEFPPPNEEARLDILK--IHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEA 366

Query: 557 ALGPIRE 563
            +  +RE
Sbjct: 367 GMYALRE 373


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  144 bits (363), Expect = 2e-34
 Identities = 86/245 (35%), Positives = 143/245 (58%), Gaps = 15/245 (6%)

Query: 327 LIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPG 385
           L+ N   ++   V + +I G     + L+E++ LP   PELF  +   P +G LL+GPPG
Sbjct: 132 LVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPG 191

Query: 386 NGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDS 445
            GKT+LA+AVA++ +  F  + ++S+  KY+GE  +L+R +F  AR+ QP IIF+DE+D+
Sbjct: 192 TGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDA 251

Query: 446 LLCERREGEHDASRRLK---TEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RF 500
           +   R      A R ++    E L + DG  +    RV ++ ATNRP  LD A+LR  R 
Sbjct: 252 IGGRRFSEGTSADREIQRTLMELLNQMDGFDTL--HRVKMIMATNRPDTLDPALLRPGRL 309

Query: 501 IKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK---ELAQLARMTDGYSGSDLTALAKDAA 557
            +++++ LPNE+ RL +LK        P+T+    +   + +++DG++G+DL  +  +A 
Sbjct: 310 DRKIHIDLPNEQARLDILK----IHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAG 365

Query: 558 LGPIR 562
           +  IR
Sbjct: 366 MFAIR 370


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  142 bits (359), Expect = 7e-34
 Identities = 91/240 (37%), Positives = 136/240 (56%), Gaps = 15/240 (6%)

Query: 333 VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTML 391
           V+      + DI G D   Q ++E V LP   PE +  +   P +G++L+GPPG GKT+L
Sbjct: 176 VEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLL 235

Query: 392 AKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERR 451
           AKAVA +++ATF  +  + L  KY+G+G KLVR LF VA E  PSI+FIDE+D++  +R 
Sbjct: 236 AKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRY 295

Query: 452 EGEHDASR---RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYV 506
           +      R   R   E L + DG  S GD +V++  ATNR + LD A++R  R  +++  
Sbjct: 296 DSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIM--ATNRIETLDPALIRPGRIDRKIEF 353

Query: 507 SLPNEETRLLLLKNLLCKQGSPLTQKE---LAQLARMTDGYSGSDLTALAKDAALGPIRE 563
            LP+E+T+    K +     S +T  +   L  L    D  SG+D+ A+  +A L  +RE
Sbjct: 354 PLPDEKTK----KRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRE 409


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  142 bits (357), Expect = 1e-33
 Identities = 91/237 (38%), Positives = 135/237 (56%), Gaps = 11/237 (4%)

Query: 333 VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTML 391
           VD     ++ DI G D   Q L E ++LP    E F  L   P +G+L++GPPG GKT+L
Sbjct: 177 VDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLL 236

Query: 392 AKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERR 451
           A+A AA++ ATF  ++   L   ++G+G KLVR  FA+A+E  PSIIFIDE+D++  +R 
Sbjct: 237 ARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRF 296

Query: 452 EGEHDASR---RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYV 506
           + E    R   R   E L + DG Q   + +V V+ ATNR   LD A+LR  R  +++  
Sbjct: 297 DSEKAGDREVQRTMLELLNQLDGFQP--NTQVKVIAATNRVDILDPALLRSGRLDRKIEF 354

Query: 507 SLPNEETRLLLLKNLLCKQG-SPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR 562
            +PNEE R  +++    K   SP    E  +LAR TD ++G+   A+  +A +  +R
Sbjct: 355 PMPNEEARARIMQIHSRKMNVSPDVNYE--ELARCTDDFNGAQCKAVCVEAGMIALR 409


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  137 bits (346), Expect = 2e-32
 Identities = 91/268 (33%), Positives = 141/268 (52%), Gaps = 14/268 (5%)

Query: 337 TAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTMLAKAV 395
           ++V+FD + G      AL+E+V+ P L PE+F   +  P RG L +GPPG GKT++A+A+
Sbjct: 421 SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL 480

Query: 396 AAESN-----ATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCER 450
           A E +       FF    A   SK+VGE E+ +R LF  A +++PSIIF DE+D L   R
Sbjct: 481 ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR 540

Query: 451 REGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSL 508
              +      + +  L   DG+ S G+  ++V+GATNR   +D A+ R  RF +    SL
Sbjct: 541 SSRQDQIHSSIVSTLLALMDGLDSRGE--IVVIGATNRLDSIDPALRRPGRFDREFLFSL 598

Query: 509 PNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQ 568
           P++E R  +LK              L +LA    GY G+D+ ++  +AAL  +R   P+ 
Sbjct: 599 PDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQI 658

Query: 569 VKNMSASEMR----NIRLSDFTESLKKI 592
                  ++     NI   DF  +++K+
Sbjct: 659 YTTSEKLQLDLSSINISAKDFEVAMQKM 686



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 37/165 (22%), Positives = 71/165 (43%), Gaps = 18/165 (10%)

Query: 378 LLLFGPPGNGK-TMLAKAVA-AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQP 435
           +L+ G PG G+ + LA AV  A    T + +    L        E+    +   A+   P
Sbjct: 795 ILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAP 854

Query: 436 SIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRP-----Q 490
           SI+++  +                 LK  F      + S     VL++  +++P     +
Sbjct: 855 SIVYVPHIHVWW-------EIVGPTLKATFTTLLQNIPSFAP--VLLLATSDKPHSALPE 905

Query: 491 ELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGS--PLTQKE 533
           E+ E  +R + +   V LP++E R    ++L+ KQ +  P+++K+
Sbjct: 906 EVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKK 950


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  136 bits (343), Expect = 5e-32
 Identities = 85/242 (35%), Positives = 133/242 (54%), Gaps = 9/242 (3%)

Query: 328 IMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGN 386
           IM    D    V + DI G D+ KQ ++E V LP    EL+  +   P RG+L++GPPG 
Sbjct: 147 IMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGC 206

Query: 387 GKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSL 446
           GKTMLAKAVA  + A F  +  +    KY+GEG ++VR +F +A+E  P+IIFIDE+D++
Sbjct: 207 GKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAI 266

Query: 447 LCERREGEHDASR---RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFI 501
             +R + +  A R   R+  E L + DG     +  V V+ ATNR   LD A+LR  R  
Sbjct: 267 ATKRFDAQTGADREVQRILLELLNQMDGFDQ--NVNVKVIMATNRADTLDPALLRPGRLD 324

Query: 502 KRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPI 561
           +++   LP+   + L+   +  K      + +L       D  SG+D+ ++ +++ +  +
Sbjct: 325 RKIEFPLPDRRQKRLIFSTITSKMNLS-EEVDLEDYVARPDKISGADINSICQESGMLAV 383

Query: 562 RE 563
           RE
Sbjct: 384 RE 385


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  136 bits (343), Expect = 5e-32
 Identities = 85/242 (35%), Positives = 133/242 (54%), Gaps = 9/242 (3%)

Query: 328 IMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGN 386
           IM    D    V + DI G D+ KQ ++E V LP    EL+  +   P RG+L++GPPG 
Sbjct: 120 IMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGC 179

Query: 387 GKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSL 446
           GKTMLAKAVA  + A F  +  +    KY+GEG ++VR +F +A+E  P+IIFIDE+D++
Sbjct: 180 GKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAI 239

Query: 447 LCERREGEHDASR---RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFI 501
             +R + +  A R   R+  E L + DG     +  V V+ ATNR   LD A+LR  R  
Sbjct: 240 ATKRFDAQTGADREVQRILLELLNQMDGFDQ--NVNVKVIMATNRADTLDPALLRPGRLD 297

Query: 502 KRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPI 561
           +++   LP+   + L+   +  K      + +L       D  SG+D+ ++ +++ +  +
Sbjct: 298 RKIEFPLPDRRQKRLIFSTITSKMNLS-EEVDLEDYVARPDKISGADINSICQESGMLAV 356

Query: 562 RE 563
           RE
Sbjct: 357 RE 358


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  136 bits (343), Expect = 5e-32
 Identities = 85/242 (35%), Positives = 133/242 (54%), Gaps = 9/242 (3%)

Query: 328 IMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGN 386
           IM    D    V + DI G D+ KQ ++E V LP    EL+  +   P RG+L++GPPG 
Sbjct: 151 IMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGC 210

Query: 387 GKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSL 446
           GKTMLAKAVA  + A F  +  +    KY+GEG ++VR +F +A+E  P+IIFIDE+D++
Sbjct: 211 GKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAI 270

Query: 447 LCERREGEHDASR---RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFI 501
             +R + +  A R   R+  E L + DG     +  V V+ ATNR   LD A+LR  R  
Sbjct: 271 ATKRFDAQTGADREVQRILLELLNQMDGFDQ--NVNVKVIMATNRADTLDPALLRPGRLD 328

Query: 502 KRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPI 561
           +++   LP+   + L+   +  K      + +L       D  SG+D+ ++ +++ +  +
Sbjct: 329 RKIEFPLPDRRQKRLIFSTITSKMNLS-EEVDLEDYVARPDKISGADINSICQESGMLAV 387

Query: 562 RE 563
           RE
Sbjct: 388 RE 389


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  136 bits (343), Expect = 5e-32
 Identities = 106/324 (32%), Positives = 159/324 (49%), Gaps = 28/324 (8%)

Query: 264 HRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSN 323
           HR+P+    S +   K     + TT     +  R  + S      R +    NFR  D  
Sbjct: 316 HRSPARR--SHIRRKKHAIHSSDTTSSDEERFER--RKSKSMARARNRCLPMNFRAED-- 369

Query: 324 LANLIMNEIVDNGTA------------VKFDDIAGQDLAKQALQEIVILPSLRPELFTGL 371
           LA+ I+ E V  G +            V+FD I G      AL+E+V+ P L PE+F   
Sbjct: 370 LASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKF 429

Query: 372 RA-PARGLLLFGPPGNGKTMLAKAVAAESN-----ATFFNISAASLTSKYVGEGEKLVRA 425
           +  P RG L +GPPG GKT++A+A+A E +       FF    A   SK+VGE E+ +R 
Sbjct: 430 KIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRL 489

Query: 426 LFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGA 485
           LF  A  ++PSIIF DE+D L   R   +      + +  L   DG+ + G+  ++V+GA
Sbjct: 490 LFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGE--IVVIGA 547

Query: 486 TNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDG 543
           TNR   +D A+ R  RF +    +LP+++ R  +L+         L+   L +LA    G
Sbjct: 548 TNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVG 607

Query: 544 YSGSDLTALAKDAALGPIRELKPE 567
           Y G+D+ AL  +AAL  +R   P+
Sbjct: 608 YCGADIKALCTEAALIALRRRYPQ 631


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  135 bits (339), Expect = 1e-31
 Identities = 100/281 (35%), Positives = 146/281 (51%), Gaps = 11/281 (3%)

Query: 338 AVKFDDIAGQDLAKQALQEIVILPSLRPELFT-GLRAPARGLLLFGPPGNGKTMLAKAVA 396
           +V + D+ G    K+ + E + LP   PEL + GLR    GLLL GPPG GKT+LAKAVA
Sbjct: 701 SVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAVA 758

Query: 397 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCER-REGEH 455
            E + TF ++    L + YVG+ E+ VR +FA AR   P IIF DE+DSL   R R G+ 
Sbjct: 759 TECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDS 818

Query: 456 -DASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEE 512
                R+ ++ L E DG+ S  D  V V+GATNRP  LD A+LR  RF K V+V    + 
Sbjct: 819 GGVMDRVVSQLLAELDGLHSTQD--VFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDR 876

Query: 513 TRLLLLKNLLCKQGSPLTQKELAQ-LARMTDGYSGSDLTALAKDAALGPIRELKPEQVKN 571
              L + + + ++        L   L       +G+DL +L  DA    ++    +  + 
Sbjct: 877 ASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEG 936

Query: 572 MS-ASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDF 611
           +   S    + + D  ++  +++ SVS Q L  Y R  + F
Sbjct: 937 LEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 64/213 (30%), Positives = 103/213 (48%), Gaps = 14/213 (6%)

Query: 358 VILPSLRP--ELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKY 415
           V+ P L+P   L TG  +    +LL GPPG GKT +  A  +        +  +SL ++ 
Sbjct: 448 VLKPRLQPGGALLTGTSS----VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAES 503

Query: 416 VGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKT--EFLIEFDGVQ 473
            G  E  ++A+F+ AR  +P+++ +  VD LL   R+G  + +R +      L+  D + 
Sbjct: 504 SGAVETKLQAIFSRARRCRPAVLLLTAVD-LLGRDRDGLGEDARVMAVLRHLLLNEDPLN 562

Query: 474 SAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK- 532
           S     ++V+  T+R Q+L   V   F   + V   +E  RL +L+ L      PL Q+ 
Sbjct: 563 SC--PPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAH--LPLGQEV 618

Query: 533 ELAQLARMTDGYSGSDLTALAKDAALGPIRELK 565
            LAQLAR   G+   DL AL   ++      +K
Sbjct: 619 NLAQLARRCAGFVVGDLYALLTHSSRAACTRIK 651


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  132 bits (333), Expect = 7e-31
 Identities = 99/259 (38%), Positives = 142/259 (54%), Gaps = 20/259 (7%)

Query: 344 IAGQDLAKQALQEIVILPSLRPELFTGLR-APARGLLLFGPPGNGKTMLAKAVAAESNAT 402
           + G   A  +L+E++ LP   P   T L  A  RG+LL GPPG GKT L +AVA E+ A 
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261

Query: 403 FFNISAASLTSKYVGEGEKLVRALFAVARELQ---PSIIFIDEVDSLLCERREGEHDASR 459
              +SA +L     GE E+ VR +F  AREL    PS++F+DE+D+L  +R  G      
Sbjct: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR--GSRAPES 319

Query: 460 RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLL 517
           R+  + L   DG  ++GD  V+V+GATNRP  LD A+ R  RF + V +  P  + R  +
Sbjct: 320 RVVAQVLTLLDG--ASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEI 377

Query: 518 LKNLLCKQGSPLTQK-ELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASE 576
           L+ +  K   P++   +L  LA MT GY G+DLTAL ++AA+  +   +  Q  N    E
Sbjct: 378 LQVITSKM--PISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQ-DNPVIDE 434

Query: 577 MRNIRLSDFTESLKKIKRS 595
           +      DF E+ K I+ S
Sbjct: 435 I------DFLEAFKNIQPS 447



 Score =  128 bits (321), Expect = 2e-29
 Identities = 98/302 (32%), Positives = 154/302 (50%), Gaps = 36/302 (11%)

Query: 339 VKFDDIAGQDLAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 396
           V +++I G +  K  L++ +  P   P  F   GL  P +G+LL+GPPG  KT L +A+A
Sbjct: 461 VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQP-KGVLLYGPPGCAKTTLVRALA 519

Query: 397 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEH- 455
              + +F ++S A L S +VG+ EK++  +F  AR   P+I+F+DE+DS+L  R   +  
Sbjct: 520 TSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTG 579

Query: 456 -DASRRLKTEFLIEFDGV-----------------QSAGDDRVLVMGATNRPQELDEAVL 497
            D   R+ +  L E DGV                 Q   +  V+++ ATNRP  LD A+L
Sbjct: 580 CDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALL 639

Query: 498 R--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPL-TQKELAQLARMTDGYSGSDLTALAK 554
           R  R  K +Y+  P+ + RL +LK  +C +  P+     L  LA  T  +SG+DL  L  
Sbjct: 640 RPGRLDKIIYIPPPDHKGRLSILK--VCTKTMPIGPDVSLENLAAETCFFSGADLRNLCT 697

Query: 555 DAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDT 614
           +AAL  ++E         +  +   ++   F +SLK +K S+S + L  Y    K  G +
Sbjct: 698 EAALLALQE---------NGLDATTVKQEHFLKSLKTVKPSLSCKDLALYENLFKKEGFS 748

Query: 615 TV 616
            V
Sbjct: 749 NV 750


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  132 bits (333), Expect = 7e-31
 Identities = 83/221 (37%), Positives = 123/221 (55%), Gaps = 6/221 (2%)

Query: 341  FDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPAR-GLLLFGPPGNGKTMLAKAVAAES 399
            +D I G    +Q L + + LP+  PELF  L    R G+LL+GPPG GKT+LA  +A ES
Sbjct: 839  WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898

Query: 400  NATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASR 459
               F ++    L SKY+G  E+ VR +F  A+  +P I+F DE +S+   R       + 
Sbjct: 899  RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTD 958

Query: 460  RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLL 517
            R+  + L + DGV+  G   V V+ AT+RP  +D A+LR  R  K VY   P++ +RL +
Sbjct: 959  RVVNQLLTQLDGVE--GLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEI 1016

Query: 518  LKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAAL 558
            L N+L          +L  +A +TD ++G+DL AL  +A L
Sbjct: 1017 L-NVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQL 1056



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 58/213 (27%), Positives = 97/213 (45%), Gaps = 30/213 (14%)

Query: 367 LFTGLRAPARGLLLFGPPGNGKTMLAKAVAAES----NATFFNISAASLTSKYVGEGEKL 422
           L  GLR  A  LLL G  G+GK+ LAKA+  E+    +A    +   +L  K +   +K 
Sbjct: 586 LVAGLRNGA--LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKT 643

Query: 423 VRALFAVARELQPSIIFIDEVDSLLCERREGEHD------ASRRLK---TEFLIEFDGVQ 473
           +   F+ A  +QPS++ +D++D +       EH+       S+RL     + + EF  + 
Sbjct: 644 LEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMG 703

Query: 474 SAGDDRVLVMGATNRPQELDEAVL------RRFIKRVYVSLPNEETRLLLL----KNLLC 523
           S     ++ + AT++ Q+    +L        F    ++  PN+E R  +L    KN L 
Sbjct: 704 S-----LVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLD 758

Query: 524 KQGSPLTQKELAQLARMTDGYSGSDLTALAKDA 556
              +  T  +L  +A+ T G+   D T L   A
Sbjct: 759 CDINKFTDLDLQHVAKETGGFVARDFTVLVDRA 791


>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
          Length = 797

 Score =  131 bits (329), Expect = 2e-30
 Identities = 93/270 (34%), Positives = 143/270 (52%), Gaps = 17/270 (6%)

Query: 304 PTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIV-ILPS 362
           P    R  + +    +V    A ++ +EI      VKF D+AG + AK  + E V  L +
Sbjct: 275 PAGIGRTGRGMGGLFSVGETTAKVLKDEI-----DVKFKDVAGCEEAKLEIMEFVNFLKN 329

Query: 363 LRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 422
            +     G + P +G +L GPPG GKT+LAKA A E+N  F  +S +     +VG G   
Sbjct: 330 PKQYQDLGAKIP-KGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPAR 388

Query: 423 VRALFAVARELQPSIIFIDEVDSLLCERREGE---HDASRRLKTEFLIEFDGVQSAGDDR 479
           VR LFA+AR+  P I+FIDE+D++  +R  G             + L+E DG  +     
Sbjct: 389 VRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTT--TN 446

Query: 480 VLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLL--CKQGSPLTQKELA 535
           V+++  TNRP  LD A+LR  RF +++++  P+ + R  + K  L   K  S L + +LA
Sbjct: 447 VVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLA 506

Query: 536 -QLARMTDGYSGSDLTALAKDAALGPIREL 564
            +LA +T G+SG+D+  +  +AAL   R L
Sbjct: 507 RKLASLTPGFSGADVANVCNEAALIAARHL 536


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,979,077
Number of Sequences: 37866
Number of extensions: 1402743
Number of successful extensions: 26297
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 393
Number of HSP's successfully gapped in prelim test: 362
Number of HSP's that attempted gapping in prelim test: 16647
Number of HSP's gapped (non-prelim): 7431
length of query: 616
length of database: 18,247,518
effective HSP length: 108
effective length of query: 508
effective length of database: 14,157,990
effective search space: 7192258920
effective search space used: 7192258920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.