Search of human proteins with 153792536

Search of human proteins with 153792536

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|153792536 ATPase family, AAA domain containing 2B [Homo
sapiens]
         (1458 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]  2902   0.0  
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]    1167   0.0  
gi|6005942 valosin-containing protein [Homo sapiens]                  220   9e-57
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              210   9e-54
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            191   6e-48
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             181   6e-45
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       175   3e-43
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           171   4e-42
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 169   1e-41
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 169   1e-41
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            169   2e-41
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            163   1e-39
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     157   7e-38
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           153   1e-36
gi|4505725 peroxin1 [Homo sapiens]                                    152   2e-36
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   150   1e-35
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   150   1e-35
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   150   1e-35
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]          149   1e-35
gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]          145   3e-34
gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]          145   3e-34
gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo sap...   145   3e-34
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]         144   6e-34
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     143   1e-33
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               141   4e-33
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               141   4e-33
gi|40806170 spastin isoform 2 [Homo sapiens]                          139   3e-32
gi|31742536 fidgetin-like 1 [Homo sapiens]                            137   1e-31
gi|112789543 fidgetin-like 1 [Homo sapiens]                           137   1e-31
gi|11875211 spastin isoform 1 [Homo sapiens]                          136   1e-31

>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score = 2902 bits (7524), Expect = 0.0
 Identities = 1458/1458 (100%), Positives = 1458/1458 (100%)

Query: 1    MVNTRKSSLRLLGSKSPGPGPGPGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGG 60
            MVNTRKSSLRLLGSKSPGPGPGPGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGG
Sbjct: 1    MVNTRKSSLRLLGSKSPGPGPGPGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGG 60

Query: 61   SGGAGVTLDEARKVEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNLSTG 120
            SGGAGVTLDEARKVEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNLSTG
Sbjct: 61   SGGAGVTLDEARKVEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNLSTG 120

Query: 121  QARLTSQPGATLPNGHSGLSLRSHPLRGEKKGDGDLSCINGDMEVRKSCRSRKNRFESVN 180
            QARLTSQPGATLPNGHSGLSLRSHPLRGEKKGDGDLSCINGDMEVRKSCRSRKNRFESVN
Sbjct: 121  QARLTSQPGATLPNGHSGLSLRSHPLRGEKKGDGDLSCINGDMEVRKSCRSRKNRFESVN 180

Query: 181  QSLLFDQLVNSTAEAVLQEMDNINIRQNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKS 240
            QSLLFDQLVNSTAEAVLQEMDNINIRQNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKS
Sbjct: 181  QSLLFDQLVNSTAEAVLQEMDNINIRQNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKS 240

Query: 241  LRRNSYGIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPI 300
            LRRNSYGIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPI
Sbjct: 241  LRRNSYGIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPI 300

Query: 301  VPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRC 360
            VPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRC
Sbjct: 301  VPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRC 360

Query: 361  LPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPL 420
            LPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPL
Sbjct: 361  LPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPL 420

Query: 421  LYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWV 480
            LYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWV
Sbjct: 421  LYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWV 480

Query: 481  GESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRG 540
            GESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRG
Sbjct: 481  GESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRG 540

Query: 541  EIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGE 600
            EIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGE
Sbjct: 541  EIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGE 600

Query: 601  LAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNI 660
            LAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNI
Sbjct: 601  LAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNI 660

Query: 661  VPASQRAVMSSGHALSPIIRPLLERSFNNILAVLQKVFPHAEISQSDKKEDIETLILEDS 720
            VPASQRAVMSSGHALSPIIRPLLERSFNNILAVLQKVFPHAEISQSDKKEDIETLILEDS
Sbjct: 661  VPASQRAVMSSGHALSPIIRPLLERSFNNILAVLQKVFPHAEISQSDKKEDIETLILEDS 720

Query: 721  EDENALSIFETNCHSGSPKKQSSSAAIHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQT 780
            EDENALSIFETNCHSGSPKKQSSSAAIHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQT
Sbjct: 721  EDENALSIFETNCHSGSPKKQSSSAAIHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQT 780

Query: 781  SHLAPALLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWW 840
            SHLAPALLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWW
Sbjct: 781  SHLAPALLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWW 840

Query: 841  EAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYIQRPIE 900
            EAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYIQRPIE
Sbjct: 841  EAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYIQRPIE 900

Query: 901  EDRRKFFQELILNQASMAPPRRKHAALCAMEVLPLALPSPPRQLSESEKSRMEDQEENTL 960
            EDRRKFFQELILNQASMAPPRRKHAALCAMEVLPLALPSPPRQLSESEKSRMEDQEENTL
Sbjct: 901  EDRRKFFQELILNQASMAPPRRKHAALCAMEVLPLALPSPPRQLSESEKSRMEDQEENTL 960

Query: 961  RELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTA 1020
            RELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTA
Sbjct: 961  RELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTA 1020

Query: 1021 KDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKE 1080
            KDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKE
Sbjct: 1021 KDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKE 1080

Query: 1081 ARIKRGLSVTSEQINPHSTGARKTETRVEEAFRHKQRNPMDVWHNSANKCAFRVRRKSRR 1140
            ARIKRGLSVTSEQINPHSTGARKTETRVEEAFRHKQRNPMDVWHNSANKCAFRVRRKSRR
Sbjct: 1081 ARIKRGLSVTSEQINPHSTGARKTETRVEEAFRHKQRNPMDVWHNSANKCAFRVRRKSRR 1140

Query: 1141 RSQWGKGIIKKRKVNNLKKDEEDTKFADYENHTEDRKLLENGEFEVSTDCHEENGEETGD 1200
            RSQWGKGIIKKRKVNNLKKDEEDTKFADYENHTEDRKLLENGEFEVSTDCHEENGEETGD
Sbjct: 1141 RSQWGKGIIKKRKVNNLKKDEEDTKFADYENHTEDRKLLENGEFEVSTDCHEENGEETGD 1200

Query: 1201 LSMTNDESSCDIMDLDQGQRLNNGAGTKENFASTEEESSNESLLVNSSSSLNPEQTSRKE 1260
            LSMTNDESSCDIMDLDQGQRLNNGAGTKENFASTEEESSNESLLVNSSSSLNPEQTSRKE
Sbjct: 1201 LSMTNDESSCDIMDLDQGQRLNNGAGTKENFASTEEESSNESLLVNSSSSLNPEQTSRKE 1260

Query: 1261 TFLKGNCLNGEASTDSFEGIPVLECQNGKLEVVSFCDSGDKCSSEQKILLEDQSKEKPET 1320
            TFLKGNCLNGEASTDSFEGIPVLECQNGKLEVVSFCDSGDKCSSEQKILLEDQSKEKPET
Sbjct: 1261 TFLKGNCLNGEASTDSFEGIPVLECQNGKLEVVSFCDSGDKCSSEQKILLEDQSKEKPET 1320

Query: 1321 STENHGDDLEKLEALECSNNEKLEPGSDVEVKDAELDKEGASKVKKYRKLILEQAKTTSL 1380
            STENHGDDLEKLEALECSNNEKLEPGSDVEVKDAELDKEGASKVKKYRKLILEQAKTTSL
Sbjct: 1321 STENHGDDLEKLEALECSNNEKLEPGSDVEVKDAELDKEGASKVKKYRKLILEQAKTTSL 1380

Query: 1381 ELVPEEPSEPVPPLIVDRERLKKLLDLLVDKSNNLAVDQLERLYSLLSQCIYRHRKDYDK 1440
            ELVPEEPSEPVPPLIVDRERLKKLLDLLVDKSNNLAVDQLERLYSLLSQCIYRHRKDYDK
Sbjct: 1381 ELVPEEPSEPVPPLIVDRERLKKLLDLLVDKSNNLAVDQLERLYSLLSQCIYRHRKDYDK 1440

Query: 1441 SQLVEEMERTVHMFETFL 1458
            SQLVEEMERTVHMFETFL
Sbjct: 1441 SQLVEEMERTVHMFETFL 1458


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score = 1167 bits (3018), Expect = 0.0
 Identities = 626/1146 (54%), Positives = 811/1146 (70%), Gaps = 64/1146 (5%)

Query: 160  NGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRQNRRSGEVERLRM 219
            NGD+EVR+SCR R +R+  VNQS+LFD+L+ +TAEAVLQ+MD++   + +R  E+E L +
Sbjct: 149  NGDVEVRRSCRIR-SRYSGVNQSMLFDKLITNTAEAVLQKMDDMKKMRRQRMRELEDLGV 207

Query: 220  WTDTEFENMDMYSRVKRR-------------RKSLRRNSYGIQNHHEVSTEGEEEESQEE 266
            + +TE  N++MY+R K++               S+  +  G    HE   E E++E  ++
Sbjct: 208  FNETEESNLNMYTRGKQKDIQRTDEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDDD 267

Query: 267  DGDI---------EVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHR 317
            D D          E EE   EEN + Y LRQRK    YQAP   P HQ+K  N  +    
Sbjct: 268  DDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRKATVYYQAPLEKPRHQRK-PNIFYSGPA 326

Query: 318  SPARRSH--------------IRRKKHAIHSSDTTSS----DEERFERRKSKSMARARNR 359
            SPAR  +              + R++HAIHSSD+TSS    DE+ FERR+ +S  RA NR
Sbjct: 327  SPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDSTSSSSSEDEQHFERRRKRSRNRAINR 386

Query: 360  CLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFP 419
            CLP+NFR ++L  GI ++R+K+GASLADVDPM +D SVRFDS+GGLS+HI ALKEMVVFP
Sbjct: 387  CLPLNFRKDEL-KGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFP 445

Query: 420  LLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKW 479
            LLYPE+FEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDK+VAFFMRKGADCLSKW
Sbjct: 446  LLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKW 505

Query: 480  VGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNR 539
            VGESERQLRLLFDQAY MRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLD+R
Sbjct: 506  VGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSR 565

Query: 540  GEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLG 599
            GEIVVIGATNRLDSIDPALRRPGRFDREFLF+LPD++ARK IL+IHTRDWNPK  D FL 
Sbjct: 566  GEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLE 625

Query: 600  ELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQN 659
            ELAE CVGYCGADIK++C EAAL ALRRRYPQIY +S KLQLD+SSI +SA+DF  AMQ 
Sbjct: 626  ELAENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQK 685

Query: 660  IVPASQRAVMSSGHALSPIIRPLLERSFNNILAVLQKVFPHAEI-SQSDKKEDIETLILE 718
            ++PASQRAV S G ALS +++PLL+ + + IL  LQ+VFPHAE  +      DI   +LE
Sbjct: 686  MIPASQRAVTSPGQALSTVVKPLLQNTVDKILEALQRVFPHAEFRTNKTLDSDISCPLLE 745

Query: 719  DS---EDENALSIFETNCHSGSPKKQSSSAAIHKPYLHFTMSPYHQPTSYRPRLLLSGER 775
                  D++  S++E    +G  +K S  A  +  +LH   +  +QP S+RPR+L+ GE 
Sbjct: 746  SDLAYSDDDVPSVYE----NGLSQKSSHKAKDNFNFLHLNRNACYQPMSFRPRILIVGEP 801

Query: 776  GSGQTSHLAPALLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPH 835
            G GQ SHLAPA++H LE+F+V+ LD+P L+ VS  +PEE+CAQ+ REA+RT PSIVY+PH
Sbjct: 802  GFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAPSIVYVPH 861

Query: 836  IGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYI 895
            I  WWE V  T++ATF TLLQ+IPSF+P+ LL+TS+  +S LPEEV+ +F   Y E+  +
Sbjct: 862  IHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPHSALPEEVQELFIRDYGEIFNV 921

Query: 896  QRPIEEDRRKFFQELILNQASMAPPRRKHAALCAMEVLPLALPSPPRQLSESEKSRMEDQ 955
            Q P +E+R KFF++LIL QA+  P  +K A L A+EVLP+A P  PR L+  E  R+E+Q
Sbjct: 922  QLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEPRSLTAEEVKRLEEQ 981

Query: 956  EENTLRELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKH 1015
            EE+T RELR+FLR+VT RLA DKRF +F+KPVD +EV DY+ VIK+PMDLS+VI+KID H
Sbjct: 982  EEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLH 1041

Query: 1016 NYLTAKDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLC 1075
             YLT KD+L+DIDLICSNALEYNPD+DPGD++IRHRAC L+DTA+AII  ELD +F +LC
Sbjct: 1042 KYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQLC 1101

Query: 1076 EEIKEARIKRGLSVTSEQINPHSTGARKTETRVEEAFRHKQRNPMDVWHNSANKCA--FR 1133
            EEI+E+R KRG S +    + +    ++  T V +     ++N      ++   C+   +
Sbjct: 1102 EEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKLKTPSTPVACSTPAQ 1161

Query: 1134 VRRKSRRRSQWGKGIIKK-RKVNNLKKDEE---DTKFADYENHTEDRKLLEN-----GEF 1184
            ++RK R++S W  G IKK RK++  K D +   D K       T+D  +  N     GE 
Sbjct: 1162 LKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIESDTEETQDTSVDHNETGNTGES 1221

Query: 1185 EVSTDCHEENGEETGDLSMTNDESSCDI-MDLDQGQRLNNGAGTKENFASTEEESSNESL 1243
             V  +  ++N  E+  L + N+ ++C+I  +L+  ++       ++  A   + SS++ +
Sbjct: 1222 SVEENEKQQNASES-KLELRNNSNTCNIENELEDSRKTTACTELRDKIACNGDASSSQII 1280

Query: 1244 LVNSSS 1249
             ++  +
Sbjct: 1281 HISDEN 1286



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 56/158 (35%), Positives = 86/158 (54%), Gaps = 9/158 (5%)

Query: 1303 SSEQKILLEDQSKEKPETSTENHGDDLEKLEAL-----ECSNNEKLEPGSDVEVKDAELD 1357
            +SE K+ L + S      + EN  +D  K  A      + + N        + + D    
Sbjct: 1232 ASESKLELRNNSNT---CNIENELEDSRKTTACTELRDKIACNGDASSSQIIHISDENEG 1288

Query: 1358 KEGAS-KVKKYRKLILEQAKTTSLELVPEEPSEPVPPLIVDRERLKKLLDLLVDKSNNLA 1416
            KE    ++ + R+  +EQ +  ++E      S+P P L+VD ERLK LL  +V KS N  
Sbjct: 1289 KEMCVLRMTRARRSQVEQQQLITVEKALAILSQPTPSLVVDHERLKNLLKTVVKKSQNYN 1348

Query: 1417 VDQLERLYSLLSQCIYRHRKDYDKSQLVEEMERTVHMF 1454
            + QLE LY+++SQCIYRHRKD+DK+ L+++ME+ V  F
Sbjct: 1349 IFQLENLYAVISQCIYRHRKDHDKTSLIQKMEQEVENF 1386


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  220 bits (560), Expect = 9e-57
 Identities = 123/272 (45%), Positives = 168/272 (61%), Gaps = 9/272 (3%)

Query: 397 VRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 456
           V +D IGG    +  +KEMV  PL +P +F+   ++PPRG L YGPPGTGKTL+ARA+AN
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260

Query: 457 ECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS 516
           E         FF+  G + +SK  GESE  LR  F++A    P+IIF DE+D +AP R  
Sbjct: 261 ETG-----AFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREK 315

Query: 517 RQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQK 576
              ++   IVS LL LMDGL  R  ++V+ ATNR +SIDPALRR GRFDRE    +PD  
Sbjct: 316 THGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDAT 375

Query: 577 ARKHILQIHTRDWNPKLS-DAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYAS 635
            R  ILQIHT+  N KL+ D  L ++A +  G+ GAD+ ALC+EAAL A+R++   I   
Sbjct: 376 GRLEILQIHTK--NMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLE 433

Query: 636 SHKLQLDV-SSIVLSAQDFYHAMQNIVPASQR 666
              +  +V +S+ ++  DF  A+    P++ R
Sbjct: 434 DETIDAEVMNSLAVTMDDFRWALSQSNPSALR 465



 Score =  176 bits (445), Expect = 2e-43
 Identities = 97/259 (37%), Positives = 146/259 (56%), Gaps = 9/259 (3%)

Query: 397 VRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 456
           V ++ IGGL      L+E+V +P+ +P+ F KF + P +G LFYGPPG GKTL+A+A+AN
Sbjct: 474 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIAN 533

Query: 457 ECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS 516
           EC     +  F   KG + L+ W GESE  +R +FD+A    P ++FFDE+D +A  R  
Sbjct: 534 EC-----QANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGG 588

Query: 517 RQDQ---IHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLP 573
                      +++ +L  MDG+  +  + +IGATNR D IDPA+ RPGR D+     LP
Sbjct: 589 NIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLP 648

Query: 574 DQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIY 633
           D+K+R  IL+ + R  +P   D  L  LA+   G+ GAD+  +C  A  +A+R       
Sbjct: 649 DEKSRVAILKANLRK-SPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEI 707

Query: 634 ASSHKLQLDVSSIVLSAQD 652
               + Q + S++ +   D
Sbjct: 708 RRERERQTNPSAMEVEEDD 726


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  210 bits (534), Expect = 9e-54
 Identities = 117/276 (42%), Positives = 172/276 (62%), Gaps = 12/276 (4%)

Query: 397 VRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 456
           V +D IGGLS  + A++E++  PL  PE+F+ + I  PRG L YGPPGTGKT++ARA+AN
Sbjct: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409

Query: 457 ECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS 516
           E       +      G + +SK+ GE+E +LR +F +A L  PSIIF DE+D L P R  
Sbjct: 410 EVGAYVSVI-----NGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREG 464

Query: 517 RQDQIHSSIVSTLLALMDGLDNR---GEIVVIGATNRLDSIDPALRRPGRFDREFLFNLP 573
            Q+++   +V++LL LMDG+ +    G+++V+GATNR  ++D ALRRPGRFD+E    +P
Sbjct: 465 AQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVP 524

Query: 574 DQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIY 633
           + + R  ILQ   R     L++A L +LA    GY GAD+K LC EA L ALRR    + 
Sbjct: 525 NAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRR---ILK 581

Query: 634 ASSHKLQLDVSSIV-LSAQDFYHAMQNIVPASQRAV 668
              +   + V+ +V ++ +DF  AM +I P++ R +
Sbjct: 582 KQPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREI 617



 Score =  171 bits (433), Expect = 5e-42
 Identities = 105/271 (38%), Positives = 150/271 (55%), Gaps = 26/271 (9%)

Query: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455
           +V +  IGGL      L++ V +PL +PE F +  IQPP+G L YGPPG  KT++A+ALA
Sbjct: 623 NVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALA 682

Query: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515
           NE       + F   KG + ++K+VGESER +R  F +A  + PSIIFFDE+D LA  R 
Sbjct: 683 NESG-----LNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERG 737

Query: 516 SR--QDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLP 573
           S      +   +++ LL  MDG++   ++ ++ ATNR D ID AL RPGR DR     LP
Sbjct: 738 SSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLP 797

Query: 574 DQKARKHI--LQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQ 631
           D   R+ I  LQ H+    P  ++  L EL  +   Y GA+I A+C EAAL+AL      
Sbjct: 798 DAATRREIFKLQFHSM---PVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEE---- 850

Query: 632 IYASSHKLQLDVSSIVLSAQDFYHAMQNIVP 662
                     D+ + ++  + F  A+  + P
Sbjct: 851 ----------DIQANLIMKRHFTQALSTVTP 871


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  191 bits (484), Expect = 6e-48
 Identities = 111/258 (43%), Positives = 156/258 (60%), Gaps = 17/258 (6%)

Query: 381 VGASLADVDP----MNIDKSVR--FDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPP 434
           +G  + D DP    M ++K+ +  +  IGGL + I  +KE V  PL +PE +E+  I+PP
Sbjct: 160 IGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPP 219

Query: 435 RGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRK-GADCLSKWVGESERQLRLLFDQ 493
           +G + YGPPGTGKTL+A+A+AN+ S      A F+R  G++ + K++G+  + +R LF  
Sbjct: 220 KGVILYGPPGTGKTLLAKAVANQTS------ATFLRVVGSELIQKYLGDGPKLVRELFRV 273

Query: 494 AYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALM---DGLDNRGEIVVIGATNR 550
           A    PSI+F DEID +   R          I  T+L L+   DG D+RG++ VI ATNR
Sbjct: 274 AEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNR 333

Query: 551 LDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCG 610
           ++++DPAL RPGR DR+  F LPD+K +K I QIHT        D  L +L        G
Sbjct: 334 IETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMT-LADDVTLDDLIMAKDDLSG 392

Query: 611 ADIKALCTEAALIALRRR 628
           ADIKA+CTEA L+ALR R
Sbjct: 393 ADIKAICTEAGLMALRER 410


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  181 bits (458), Expect = 6e-45
 Identities = 107/271 (39%), Positives = 153/271 (56%), Gaps = 16/271 (5%)

Query: 368 EDLASGILRERVKVGASLAD-VDP----MNIDKS--VRFDSIGGLSHHIHALKEMVVFPL 420
           E +  G+ R + ++   L   +DP    M +++   V +  +GG    I  L+E+V  PL
Sbjct: 136 EGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPL 195

Query: 421 LYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWV 480
           L+PE F    I+PP+G L +GPPGTGKTL ARA+AN          F    G++ + K+V
Sbjct: 196 LHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTD-----ACFIRVIGSELVQKYV 250

Query: 481 GESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLD 537
           GE  R +R LF+ A   +  +IFFDEID +   R        + +  T+L L   +DG D
Sbjct: 251 GEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFD 310

Query: 538 NRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAF 597
            RG I V+ ATNR D++DPAL RPGR DR+  F+LPD + R HI +IH R  + +  D  
Sbjct: 311 PRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVE-RDIR 369

Query: 598 LGELAEKCVGYCGADIKALCTEAALIALRRR 628
              LA  C    GA+I+++CTEA + A+R R
Sbjct: 370 FELLARLCPNSTGAEIRSVCTEAGMFAIRAR 400


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  175 bits (443), Expect = 3e-43
 Identities = 114/271 (42%), Positives = 152/271 (56%), Gaps = 22/271 (8%)

Query: 402 IGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQG 461
           +GGLS    +L+E++  PL YP       +  PRG L  GPPG GKT + RA+A E    
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261

Query: 462 DKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMR---PSIIFFDEIDGLAPVRSSRQ 518
              V+    +G+       GE+E  +R +F +A  +    PS++F DE+D L P R SR 
Sbjct: 262 LLAVSAPALQGSR-----PGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSRA 316

Query: 519 DQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKAR 578
            +  S +V+ +L L+DG     E+VV+GATNR D++DPALRRPGRFDRE +   P  K R
Sbjct: 317 PE--SRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQR 374

Query: 579 KHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHK 638
           K ILQ+ T    P  S   LG LAE  VGY GAD+ ALC EAA+ AL          S K
Sbjct: 375 KEILQVITSKM-PISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL--------LHSEK 425

Query: 639 LQLDVSSIVLSAQDFYHAMQNIVPASQRAVM 669
            Q    + V+   DF  A +NI P+S R+V+
Sbjct: 426 NQ---DNPVIDEIDFLEAFKNIQPSSFRSVI 453



 Score =  146 bits (368), Expect = 2e-34
 Identities = 94/253 (37%), Positives = 134/253 (52%), Gaps = 27/253 (10%)

Query: 395 KSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARAL 454
           K V ++ IGGL      LK+ + +PL +P  F +  +  P+G L YGPPG  KT + RAL
Sbjct: 459 KPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRAL 518

Query: 455 ANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVR 514
           A  C       +F    GAD  S +VG+SE+ L  +F QA    P+I+F DEID +   R
Sbjct: 519 ATSC-----HCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGAR 573

Query: 515 SSRQD--QIHSSIVSTLLALMDG-----LDNRG--------------EIVVIGATNRLDS 553
           S+ +    +   ++S LL  +DG     ++ RG               +++I ATNR D 
Sbjct: 574 SASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDV 633

Query: 554 IDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADI 613
           +D AL RPGR D+      PD K R  IL++ T+   P   D  L  LA +   + GAD+
Sbjct: 634 LDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTM-PIGPDVSLENLAAETCFFSGADL 692

Query: 614 KALCTEAALIALR 626
           + LCTEAAL+AL+
Sbjct: 693 RNLCTEAALLALQ 705


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  171 bits (434), Expect = 4e-42
 Identities = 101/249 (40%), Positives = 145/249 (58%), Gaps = 15/249 (6%)

Query: 387 DVDPMNIDKS------VRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFY 440
           +VDP+  + S      V +  IGGLS  I  L+E++  PL  PE+F++  I PP+GCL Y
Sbjct: 128 EVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLY 187

Query: 441 GPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPS 500
           GPPGTGKTL+ARA+A++      KV       +  + K++GES R +R +F+ A   +P 
Sbjct: 188 GPPGTGKTLLARAVASQLDCNFLKVV-----SSSIVDKYIGESARLIREMFNYARDHQPC 242

Query: 501 IIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDNRGEIVVIGATNRLDSIDPA 557
           IIF DEID +   R S        I  TL+ L   MDG D    + +I ATNR D++DPA
Sbjct: 243 IIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPA 302

Query: 558 LRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALC 617
           L RPGR DR+   +LP+++AR  IL+IH      K  +     + +   G+ GAD++ +C
Sbjct: 303 LLRPGRLDRKIHIDLPNEQARLDILKIHAGPIT-KHGEIDYEAIVKLSDGFNGADLRNVC 361

Query: 618 TEAALIALR 626
           TEA + A+R
Sbjct: 362 TEAGMFAIR 370


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  169 bits (429), Expect = 1e-41
 Identities = 158/569 (27%), Positives = 251/569 (44%), Gaps = 87/569 (15%)

Query: 335 SDTTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNID 394
           S    SD +R  + K+K   R +     ++   E     +L+++ K       +      
Sbjct: 104 SSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIE----AVLQKKAKARGLEFQIS----- 154

Query: 395 KSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARAL 454
            +V+F+ +GG    +  + +M++  + +PE++    + PPRG L +GPPG GKTL+A A+
Sbjct: 155 -NVKFEDVGGNDMTLKEVCKMLIH-MRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAI 212

Query: 455 ANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVR 514
           A E      KVA       + +S   GESE++LR LF+QA    P IIF DEID + P R
Sbjct: 213 AGELDLPILKVA-----APEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKR 267

Query: 515 SSRQDQIHSSIVSTLLALMDGLDN---RGEIVVIGATNRLDSIDPALRRPGRFDREFLFN 571
                 +   IV+ LL  MD L+N      ++VIGATNR DS+DPALRR GRFDRE    
Sbjct: 268 EVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLG 327

Query: 572 LPDQKARKHILQIHTRDWNPKLSDAF-LGELAEKCVGYCGADIKALCTEAALIALRRRYP 630
           +PD+ +R+ ILQ   R    +L  AF    LA    G+ GAD+ ALC EAA+ A+ R   
Sbjct: 328 IPDEASRERILQTLCR--KLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLM 385

Query: 631 QIYASSHKLQLDVSSIVLSAQDFYHAMQNIVPASQRAVMSSGHALSPIIR---PLLERSF 687
           ++     K   +     L ++          P S+         L  ++R   PL E   
Sbjct: 386 KLQEQQKK---NPEMEDLPSKGVQEERLGTEPTSE--TQDELQRLLGLLRDQDPLSEEQM 440

Query: 688 NNILAVLQK-VFPHAEISQSDKKEDIETL---------ILEDSEDENALSIFETNCHSGS 737
             +   L   +   + +  S K+E   T+          LED  +E  ++I         
Sbjct: 441 QGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAI--------- 491

Query: 738 PKKQSSSAAIHKPYLHFTMSPYHQPTSYR-------PRLLLSGERGSGQTSHLAPALLHT 790
                             ++P   P  ++         +LL+G  G G+T  LA A+ + 
Sbjct: 492 ------------------LAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTL-LAKAVANE 532

Query: 791 --LERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYM-------PHIGDWWE 841
             L   SV     P L ++     E +  Q+F+ A+ + P +++        P   D   
Sbjct: 533 SGLNFISVKG---PELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589

Query: 842 AVSETVRATFLTLLQDIPSFSPIFLLSTS 870
             S  V    LT +  + +   +F+++ +
Sbjct: 590 GASVRVVNQLLTEMDGLEARQQVFIMAAT 618



 Score =  157 bits (397), Expect = 7e-38
 Identities = 98/255 (38%), Positives = 142/255 (55%), Gaps = 13/255 (5%)

Query: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455
           +V +  IG L      L   ++ P+  P+ F+   +  P G L  GPPG GKTL+A+A+A
Sbjct: 471 NVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVA 530

Query: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515
           NE       + F   KG + L+ +VGESER +R +F +A    P +IFFDE+D L P RS
Sbjct: 531 NESG-----LNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRS 585

Query: 516 SRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQ 575
            R+      +V+ LL  MDGL+ R ++ ++ ATNR D IDPA+ RPGR D+     LP  
Sbjct: 586 DRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPP 645

Query: 576 KARKHILQIHTRD-WNPKLS-----DAFLGELAEKCVGYCGADIKALCTEAALIALRRRY 629
             R  IL+  T++   P L      +A  G+L  +C  Y GAD+ AL  EA++ ALR+  
Sbjct: 646 ADRLAILKTITKNGTKPPLDADVNLEAIAGDL--RCDCYTGADLSALVREASICALRQEM 703

Query: 630 PQIYASSHKLQLDVS 644
            +  + + K +L VS
Sbjct: 704 ARQKSGNEKGELKVS 718


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  169 bits (429), Expect = 1e-41
 Identities = 158/569 (27%), Positives = 251/569 (44%), Gaps = 87/569 (15%)

Query: 335 SDTTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNID 394
           S    SD +R  + K+K   R +     ++   E     +L+++ K       +      
Sbjct: 210 SSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIE----AVLQKKAKARGLEFQIS----- 260

Query: 395 KSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARAL 454
            +V+F+ +GG    +  + +M++  + +PE++    + PPRG L +GPPG GKTL+A A+
Sbjct: 261 -NVKFEDVGGNDMTLKEVCKMLIH-MRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAI 318

Query: 455 ANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVR 514
           A E      KVA       + +S   GESE++LR LF+QA    P IIF DEID + P R
Sbjct: 319 AGELDLPILKVA-----APEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKR 373

Query: 515 SSRQDQIHSSIVSTLLALMDGLDN---RGEIVVIGATNRLDSIDPALRRPGRFDREFLFN 571
                 +   IV+ LL  MD L+N      ++VIGATNR DS+DPALRR GRFDRE    
Sbjct: 374 EVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLG 433

Query: 572 LPDQKARKHILQIHTRDWNPKLSDAF-LGELAEKCVGYCGADIKALCTEAALIALRRRYP 630
           +PD+ +R+ ILQ   R    +L  AF    LA    G+ GAD+ ALC EAA+ A+ R   
Sbjct: 434 IPDEASRERILQTLCR--KLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLM 491

Query: 631 QIYASSHKLQLDVSSIVLSAQDFYHAMQNIVPASQRAVMSSGHALSPIIR---PLLERSF 687
           ++     K   +     L ++          P S+         L  ++R   PL E   
Sbjct: 492 KLQEQQKK---NPEMEDLPSKGVQEERLGTEPTSE--TQDELQRLLGLLRDQDPLSEEQM 546

Query: 688 NNILAVLQK-VFPHAEISQSDKKEDIETL---------ILEDSEDENALSIFETNCHSGS 737
             +   L   +   + +  S K+E   T+          LED  +E  ++I         
Sbjct: 547 QGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAI--------- 597

Query: 738 PKKQSSSAAIHKPYLHFTMSPYHQPTSYR-------PRLLLSGERGSGQTSHLAPALLHT 790
                             ++P   P  ++         +LL+G  G G+T  LA A+ + 
Sbjct: 598 ------------------LAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTL-LAKAVANE 638

Query: 791 --LERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYM-------PHIGDWWE 841
             L   SV     P L ++     E +  Q+F+ A+ + P +++        P   D   
Sbjct: 639 SGLNFISVKG---PELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 695

Query: 842 AVSETVRATFLTLLQDIPSFSPIFLLSTS 870
             S  V    LT +  + +   +F+++ +
Sbjct: 696 GASVRVVNQLLTEMDGLEARQQVFIMAAT 724



 Score =  157 bits (397), Expect = 7e-38
 Identities = 98/255 (38%), Positives = 142/255 (55%), Gaps = 13/255 (5%)

Query: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455
           +V +  IG L      L   ++ P+  P+ F+   +  P G L  GPPG GKTL+A+A+A
Sbjct: 577 NVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVA 636

Query: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515
           NE       + F   KG + L+ +VGESER +R +F +A    P +IFFDE+D L P RS
Sbjct: 637 NESG-----LNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRS 691

Query: 516 SRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQ 575
            R+      +V+ LL  MDGL+ R ++ ++ ATNR D IDPA+ RPGR D+     LP  
Sbjct: 692 DRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPP 751

Query: 576 KARKHILQIHTRD-WNPKLS-----DAFLGELAEKCVGYCGADIKALCTEAALIALRRRY 629
             R  IL+  T++   P L      +A  G+L  +C  Y GAD+ AL  EA++ ALR+  
Sbjct: 752 ADRLAILKTITKNGTKPPLDADVNLEAIAGDL--RCDCYTGADLSALVREASICALRQEM 809

Query: 630 PQIYASSHKLQLDVS 644
            +  + + K +L VS
Sbjct: 810 ARQKSGNEKGELKVS 824


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  169 bits (427), Expect = 2e-41
 Identities = 99/252 (39%), Positives = 145/252 (57%), Gaps = 11/252 (4%)

Query: 399 FDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANEC 458
           ++ IGGL   I  +KE++  P+ +PE+FE   I  P+G L YGPPGTGKTL+ARA+A+  
Sbjct: 148 YEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHT 207

Query: 459 SQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQ 518
                   F    G++ + K++GE  R +R LF  A    PSIIF DEID +   R    
Sbjct: 208 D-----CTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGG 262

Query: 519 DQIHSSIVSTLLAL---MDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQ 575
               S +  T+L L   +DG +    I VI ATNR+D +D AL RPGR DR+  F  P++
Sbjct: 263 SGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNE 322

Query: 576 KARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYAS 635
           +AR  IL+IH+R  N       L ++AE   G  GA++K +CTEA + ALR R  +++ +
Sbjct: 323 EARLDILKIHSRKMN-LTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRER--RVHVT 379

Query: 636 SHKLQLDVSSIV 647
               ++ V+ ++
Sbjct: 380 QEDFEMAVAKVM 391


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  163 bits (413), Expect = 1e-39
 Identities = 98/245 (40%), Positives = 134/245 (54%), Gaps = 11/245 (4%)

Query: 388 VDPMNIDK--SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGT 445
           V  M +D+  + ++  IGGL   I  L E +V P+ + E FE   IQPP+G L YGPPGT
Sbjct: 172 VKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGT 231

Query: 446 GKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFD 505
           GKTL+ARA A        K  F    G   +  ++G+  + +R  F  A    PSIIF D
Sbjct: 232 GKTLLARACA-----AQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFID 286

Query: 506 EIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDNRGEIVVIGATNRLDSIDPALRRPG 562
           E+D +   R   +      +  T+L L   +DG     ++ VI ATNR+D +DPAL R G
Sbjct: 287 ELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSG 346

Query: 563 RFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAAL 622
           R DR+  F +P+++AR  I+QIH+R  N    D    ELA     + GA  KA+C EA +
Sbjct: 347 RLDRKIEFPMPNEEARARIMQIHSRKMNVS-PDVNYEELARCTDDFNGAQCKAVCVEAGM 405

Query: 623 IALRR 627
           IALRR
Sbjct: 406 IALRR 410


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  157 bits (397), Expect = 7e-38
 Identities = 124/403 (30%), Positives = 192/403 (47%), Gaps = 35/403 (8%)

Query: 271 EVEEAEGEENDRPYNLRQRKTVD---RYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRR 327
           ++  +EGE    P  + +R +     R  +    P     R +T   +HRS A+  H  R
Sbjct: 89  DLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDR 148

Query: 328 KKHAIHSSDTTSSDEERFERRKSKS-MARARNRCLPMNFRAEDLASGILRERVKVGASLA 386
            K A+   +    ++ R E+ KS + +              +DL   + R          
Sbjct: 149 GK-AVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALER---------- 197

Query: 387 DVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTG 446
             D ++ + +VR+D I  L      LKE VV P+  PE F+  + +P +G L  GPPGTG
Sbjct: 198 --DIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIR-RPWKGVLMVGPPGTG 254

Query: 447 KTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDE 506
           KTL+A+A+A EC     K  FF    +   SK+ GESE+ +RLLF+ A    P+ IF DE
Sbjct: 255 KTLLAKAVATEC-----KTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDE 309

Query: 507 IDGLAPVR-SSRQDQIHSSIVSTLLALMDGLDNRGE-------IVVIGATNRLDSIDPAL 558
           ID +   R +S + +    + + LL  MDG+    E       ++V+ ATN    ID AL
Sbjct: 310 IDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEAL 369

Query: 559 RRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCT 618
           RR  R ++     LP  K R+ +L+I  R+      D  L  +AE   GY GADI  +C 
Sbjct: 370 RR--RLEKRIYIPLPSAKGREELLRISLRELE-LADDVDLASIAENMEGYSGADITNVCR 426

Query: 619 EAALIALRRRYPQIYASS-HKLQLDVSSIVLSAQDFYHAMQNI 660
           +A+L+A+RRR   +       L  +   +  + +DF  A++ +
Sbjct: 427 DASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKV 469


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  153 bits (387), Expect = 1e-36
 Identities = 99/271 (36%), Positives = 152/271 (56%), Gaps = 13/271 (4%)

Query: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455
           SV +  +GGL      + E +  PL +PE+      +   G L +GPPGTGKTL+A+A+A
Sbjct: 701 SVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAVA 758

Query: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515
            ECS     + F   KG + ++ +VG+SE  +R +F +A    P IIFFDE+D LAP R 
Sbjct: 759 TECS-----LTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRG 813

Query: 516 SRQDQ--IHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDR-EFLFNL 572
              D   +   +VS LLA +DGL +  ++ VIGATNR D +DPAL RPGRFD+  F+   
Sbjct: 814 RSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGAN 873

Query: 573 PDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQI 632
            D+ ++  +L   TR +  + S + +  L        GAD+ +LC++A   AL+RR   +
Sbjct: 874 EDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRR---V 930

Query: 633 YASSHKLQLDVSSIVLSAQDFYHAMQNIVPA 663
           +     L+   S+++L+ +D   A   + P+
Sbjct: 931 HDLEEGLEPGSSALMLTMEDLLQAAARLQPS 961



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 58/236 (24%), Positives = 100/236 (42%), Gaps = 13/236 (5%)

Query: 438 LFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLM 497
           L  GPPG GKT V  A  +       KV       +   ++  G  E +L+ +F +A   
Sbjct: 467 LLRGPPGCGKTTVVAAACSHLGLHLLKVPC-----SSLCAESSGAVETKLQAIFSRARRC 521

Query: 498 RPSIIFFDEIDGLAPVRSS-RQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDP 556
           RP+++    +D L   R    +D    +++  LL   D L++   ++V+  T+R   +  
Sbjct: 522 RPAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPA 581

Query: 557 ALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKAL 616
            ++    F  E       +  R  IL+  T    P   +  L +LA +C G+   D+ AL
Sbjct: 582 DVQT--AFPHELEVPALSEGQRLSILRALTAHL-PLGQEVNLAQLARRCAGFVVGDLYAL 638

Query: 617 CTEAALIALRRRYPQIYA----SSHKLQLDVSSIVLSAQDFYHAMQNIVPASQRAV 668
            T ++  A  R      A       + +L  +   L A+DF  A++ +  A  +AV
Sbjct: 639 LTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAV 694


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  152 bits (385), Expect = 2e-36
 Identities = 101/302 (33%), Positives = 150/302 (49%), Gaps = 13/302 (4%)

Query: 324  HIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGA 383
            H+ ++     + D T   +     R S+     R + +      +    G L       A
Sbjct: 771  HVAKETGGFVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLP------A 824

Query: 384  SLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPP 443
            SL  V+ ++  + + +D IGGL      L + +  P  YPE+F    I+   G L YGPP
Sbjct: 825  SLRSVN-LHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPP 883

Query: 444  GTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIF 503
            GTGKTL+A  +A E      ++ F   KG + LSK++G SE+ +R +F +A   +P I+F
Sbjct: 884  GTGKTLLAGVIARE-----SRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILF 938

Query: 504  FDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGR 563
            FDE + +AP R      +   +V+ LL  +DG++    + V+ AT+R D IDPAL RPGR
Sbjct: 939  FDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGR 998

Query: 564  FDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALI 623
             D+      PDQ +R  IL +   D  P   D  L  +A     + GAD+KAL   A L 
Sbjct: 999  LDKCVYCPPPDQVSRLEILNV-LSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLE 1057

Query: 624  AL 625
            AL
Sbjct: 1058 AL 1059



 Score = 47.8 bits (112), Expect = 8e-05
 Identities = 65/247 (26%), Positives = 107/247 (43%), Gaps = 29/247 (11%)

Query: 438 LFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCL-SKWVGESERQLRLLFDQAYL 496
           L  G  G+GK+ +A+A+  E    DK  A   R     L  K +   ++ L + F +A  
Sbjct: 596 LLTGGKGSGKSTLAKAICKEAF--DKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVW 653

Query: 497 MRPSIIFFDEIDGLA-----PVRSSRQDQIHSS-IVSTLLALMDGLDNRGEIVVIGATNR 550
           M+PS++  D++D +A     P      D + S  +   L  ++    + G +V + AT++
Sbjct: 654 MQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQ 713

Query: 551 LD-SIDPAL---RRPGRFDREFLFNLPDQKARKHILQIHTR-----DWNPKLSDAFLGEL 601
              S+ P L   +    F        P+Q+ R  IL    +     D N K +D  L  +
Sbjct: 714 SQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDIN-KFTDLDLQHV 772

Query: 602 AEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNIV 661
           A++  G+   D   L   A    L R   Q  ++  KL       VL+  DF  A++  +
Sbjct: 773 AKETGGFVARDFTVLVDRAIHSRLSR---QSISTREKL-------VLTTLDFQKALRGFL 822

Query: 662 PASQRAV 668
           PAS R+V
Sbjct: 823 PASLRSV 829


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  150 bits (378), Expect = 1e-35
 Identities = 101/280 (36%), Positives = 147/280 (52%), Gaps = 29/280 (10%)

Query: 370 LASGILRERVKVGASLA---------DVDPMNIDKS-----------VRFDSIGGLSHHI 409
           + S I RE +K  AS+A         DV P   D S           V +  IGG+    
Sbjct: 111 ILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQK 170

Query: 410 HALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFM 469
             ++E V  PL + E++++  I PPRG L YGPPG GKT++A+A+A+  +      AF  
Sbjct: 171 QEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTT-----AAFIR 225

Query: 470 RKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQ---DQIHSSIV 526
             G++ + K++GE  R +R +F  A    P+IIF DEID +A  R   Q   D+    I+
Sbjct: 226 VVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRIL 285

Query: 527 STLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHT 586
             LL  MDG D    + VI ATNR D++DPAL RPGR DR+  F LPD++ ++ I    T
Sbjct: 286 LELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTIT 345

Query: 587 RDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALR 626
              N    +  L +   +     GADI ++C E+ ++A+R
Sbjct: 346 SKMNLS-EEVDLEDYVARPDKISGADINSICQESGMLAVR 384


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  150 bits (378), Expect = 1e-35
 Identities = 101/280 (36%), Positives = 147/280 (52%), Gaps = 29/280 (10%)

Query: 370 LASGILRERVKVGASLA---------DVDPMNIDKS-----------VRFDSIGGLSHHI 409
           + S I RE +K  AS+A         DV P   D S           V +  IGG+    
Sbjct: 84  ILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQK 143

Query: 410 HALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFM 469
             ++E V  PL + E++++  I PPRG L YGPPG GKT++A+A+A+  +      AF  
Sbjct: 144 QEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTT-----AAFIR 198

Query: 470 RKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQ---DQIHSSIV 526
             G++ + K++GE  R +R +F  A    P+IIF DEID +A  R   Q   D+    I+
Sbjct: 199 VVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRIL 258

Query: 527 STLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHT 586
             LL  MDG D    + VI ATNR D++DPAL RPGR DR+  F LPD++ ++ I    T
Sbjct: 259 LELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTIT 318

Query: 587 RDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALR 626
              N    +  L +   +     GADI ++C E+ ++A+R
Sbjct: 319 SKMNLS-EEVDLEDYVARPDKISGADINSICQESGMLAVR 357


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  150 bits (378), Expect = 1e-35
 Identities = 101/280 (36%), Positives = 147/280 (52%), Gaps = 29/280 (10%)

Query: 370 LASGILRERVKVGASLA---------DVDPMNIDKS-----------VRFDSIGGLSHHI 409
           + S I RE +K  AS+A         DV P   D S           V +  IGG+    
Sbjct: 115 ILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQK 174

Query: 410 HALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFM 469
             ++E V  PL + E++++  I PPRG L YGPPG GKT++A+A+A+  +      AF  
Sbjct: 175 QEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTT-----AAFIR 229

Query: 470 RKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQ---DQIHSSIV 526
             G++ + K++GE  R +R +F  A    P+IIF DEID +A  R   Q   D+    I+
Sbjct: 230 VVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRIL 289

Query: 527 STLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHT 586
             LL  MDG D    + VI ATNR D++DPAL RPGR DR+  F LPD++ ++ I    T
Sbjct: 290 LELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTIT 349

Query: 587 RDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALR 626
              N    +  L +   +     GADI ++C E+ ++A+R
Sbjct: 350 SKMNLS-EEVDLEDYVARPDKISGADINSICQESGMLAVR 388


>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
          Length = 437

 Score =  149 bits (377), Expect = 1e-35
 Identities = 85/233 (36%), Positives = 134/233 (57%), Gaps = 8/233 (3%)

Query: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455
           ++R++ + GL     ALKE V+ P+ +P +F   K  P RG L +GPPGTGK+ +A+A+A
Sbjct: 123 NIRWNDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWRGILLFGPPGTGKSYLAKAVA 181

Query: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515
            E +       FF    +D +SKW+GESE+ ++ LF+ A   +PSIIF DE+D L   R+
Sbjct: 182 TEANNS----TFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRN 237

Query: 516 SRQDQIHSSIVSTLLALMDGLDNRGE-IVVIGATNRLDSIDPALRRPGRFDREFLFNLPD 574
             + +    I +  L  M G+ N  +  +V+GATN    +D A+RR  RF++     LP+
Sbjct: 238 ENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPE 295

Query: 575 QKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRR 627
           + AR  + ++H       L+DA + ELA K  GY GADI  +  ++ +  +R+
Sbjct: 296 EAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRK 348


>gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  145 bits (366), Expect = 3e-34
 Identities = 92/287 (32%), Positives = 151/287 (52%), Gaps = 35/287 (12%)

Query: 374 ILRERVK--VGASLADVDP----MNIDKSVR--FDSIGGLSHHIHALKEMVVFPLLYPEI 425
           +LR +V   +G  + D  P    M ++K+ +  + + GGL + I  +KE +  PL +PE 
Sbjct: 138 LLRHKVHAVIGVLMDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESMELPLPHPEY 197

Query: 426 FEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESER 485
           +E+   +PP+G +  GPPGT                     F    G++ + K++G+  +
Sbjct: 198 YEEMGTKPPKGVILCGPPGTA-------------------TFLRVVGSELIQKYLGDGPK 238

Query: 486 QLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL-----MDGLDNRG 540
            +R +F  A    PSI+F DEI+ +   R          I  T+L L     + G D+R 
Sbjct: 239 LVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGFDSRE 298

Query: 541 EIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGE 600
           ++ VI AT +++++DP L RPGR D++  F+LPD+K +KHI QIHT       +D  L +
Sbjct: 299 DVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMT-LANDVTLDD 357

Query: 601 LAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIV 647
           L      + GADIKA+CTEA L+ALR    ++ A++   +  + S++
Sbjct: 358 LIMAKDDFSGADIKAICTEAGLMALREH--RMKATNEDFKKSIESVL 402


>gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  145 bits (366), Expect = 3e-34
 Identities = 92/287 (32%), Positives = 151/287 (52%), Gaps = 35/287 (12%)

Query: 374 ILRERVK--VGASLADVDP----MNIDKSVR--FDSIGGLSHHIHALKEMVVFPLLYPEI 425
           +LR +V   +G  + D  P    M ++K+ +  + + GGL + I  +KE +  PL +PE 
Sbjct: 138 LLRHKVHAVIGVLMDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESMELPLPHPEY 197

Query: 426 FEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESER 485
           +E+   +PP+G +  GPPGT                     F    G++ + K++G+  +
Sbjct: 198 YEEMGTKPPKGVILCGPPGTA-------------------TFLRVVGSELIQKYLGDGPK 238

Query: 486 QLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL-----MDGLDNRG 540
            +R +F  A    PSI+F DEI+ +   R          I  T+L L     + G D+R 
Sbjct: 239 LVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGFDSRE 298

Query: 541 EIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGE 600
           ++ VI AT +++++DP L RPGR D++  F+LPD+K +KHI QIHT       +D  L +
Sbjct: 299 DVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMT-LANDVTLDD 357

Query: 601 LAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIV 647
           L      + GADIKA+CTEA L+ALR    ++ A++   +  + S++
Sbjct: 358 LIMAKDDFSGADIKAICTEAGLMALREH--RMKATNEDFKKSIESVL 402


>gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo
           sapiens]
          Length = 415

 Score =  145 bits (366), Expect = 3e-34
 Identities = 92/287 (32%), Positives = 151/287 (52%), Gaps = 35/287 (12%)

Query: 374 ILRERVK--VGASLADVDP----MNIDKSVR--FDSIGGLSHHIHALKEMVVFPLLYPEI 425
           +LR +V   +G  + D  P    M ++K+ +  + + GGL + I  +KE +  PL +PE 
Sbjct: 138 LLRHKVHAVIGVLMDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESMELPLPHPEY 197

Query: 426 FEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESER 485
           +E+   +PP+G +  GPPGT                     F    G++ + K++G+  +
Sbjct: 198 YEEMGTKPPKGVILCGPPGTA-------------------TFLRVVGSELIQKYLGDGPK 238

Query: 486 QLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL-----MDGLDNRG 540
            +R +F  A    PSI+F DEI+ +   R          I  T+L L     + G D+R 
Sbjct: 239 LVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGFDSRE 298

Query: 541 EIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGE 600
           ++ VI AT +++++DP L RPGR D++  F+LPD+K +KHI QIHT       +D  L +
Sbjct: 299 DVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMT-LANDVTLDD 357

Query: 601 LAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIV 647
           L      + GADIKA+CTEA L+ALR    ++ A++   +  + S++
Sbjct: 358 LIMAKDDFSGADIKAICTEAGLMALREH--RMKATNEDFKKSIESVL 402


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score =  144 bits (363), Expect = 6e-34
 Identities = 89/234 (38%), Positives = 131/234 (55%), Gaps = 10/234 (4%)

Query: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455
           +V++  + GL     ALKE V+ P+ +P +F   K  P RG L +GPPGTGK+ +A+A+A
Sbjct: 130 NVKWSDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWRGILLFGPPGTGKSYLAKAVA 188

Query: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515
            E +       FF    +D +SKW+GESE+ ++ LF  A   +PSIIF DEID L   RS
Sbjct: 189 TEANNS----TFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRS 244

Query: 516 SRQDQIHSSIVSTLLALMD--GLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLP 573
             + +    I +  L  M   G+DN G I+V+GATN    +D A+RR  RF++     LP
Sbjct: 245 ENESEAARRIKTEFLVQMQGVGVDNDG-ILVLGATNIPWVLDSAIRR--RFEKRIYIPLP 301

Query: 574 DQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRR 627
           +  AR  + ++H       L++A   EL  K  GY GADI  +  +A +  +R+
Sbjct: 302 EPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRK 355


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  143 bits (360), Expect = 1e-33
 Identities = 96/284 (33%), Positives = 149/284 (52%), Gaps = 18/284 (6%)

Query: 388 VDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKI-QPPRGCLFYGPPGTG 446
           VDP+N+   V +  I GL   I  LK+ V+ P+    +FE  ++ QPP+G L YGPPG G
Sbjct: 81  VDPLNMH--VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCG 138

Query: 447 KTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDE 506
           KTL+A+A A E         F   + +    KW GES++    +F  A  ++PSIIF DE
Sbjct: 139 KTLIAKATAKEAG-----CRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDE 193

Query: 507 IDGLAPVRSSRQDQIHSSIVSTLLALMDGL--DNRGEIVVIGATNRLDSIDPALRRPGRF 564
           ID     RSS   +  + + +  ++L DGL  D+  +++V+GATNR   +D A+ R  R 
Sbjct: 194 IDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMR--RM 251

Query: 565 DREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIA 624
              F  N P  K R+ IL++  ++ N       L E+A++  G+ G+D+K +C +AAL+ 
Sbjct: 252 PTRFHINQPALKQREAILKLILKNENVDRHVDLL-EVAQETDGFSGSDLKEMCRDAALLC 310

Query: 625 LRRRYPQIYASSHKLQLDVSSI-VLSAQDFYHAMQNIVPASQRA 667
           +R         SH    D   I  +  QD + A++ +  +   A
Sbjct: 311 VREYVNSTSEESH----DEDEIRPVQQQDLHRAIEKMKKSKDAA 350


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  141 bits (356), Expect = 4e-33
 Identities = 93/248 (37%), Positives = 137/248 (55%), Gaps = 17/248 (6%)

Query: 389 DPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKT 448
           D ++ + S+ +D I  L      L+E VV P+  P+ F+  + +P +G L  GPPGTGKT
Sbjct: 197 DIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKT 255

Query: 449 LVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEID 508
           ++A+A+A EC        FF    +   SK+ GESE+ +RLLF+ A    P+ IF DEID
Sbjct: 256 MLAKAVATECG-----TTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEID 310

Query: 509 GLAPVR-SSRQDQIHSSIVSTLLALMDGL-------DNRGEIVVIGATNRLDSIDPALRR 560
            +   R +S + +    + S LL  MDG+       D    ++V+ ATN    ID ALRR
Sbjct: 311 SICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR 370

Query: 561 PGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEA 620
             R ++     LP  K R  +L+I+ R+      D  L ++AEK  GY GADI  +C +A
Sbjct: 371 --RLEKRIYIPLPTAKGRAELLKINLREVELD-PDIQLEDIAEKIEGYSGADITNVCRDA 427

Query: 621 ALIALRRR 628
           +L+A+RRR
Sbjct: 428 SLMAMRRR 435


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  141 bits (356), Expect = 4e-33
 Identities = 93/248 (37%), Positives = 137/248 (55%), Gaps = 17/248 (6%)

Query: 389 DPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKT 448
           D ++ + S+ +D I  L      L+E VV P+  P+ F+  + +P +G L  GPPGTGKT
Sbjct: 197 DIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKT 255

Query: 449 LVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEID 508
           ++A+A+A EC        FF    +   SK+ GESE+ +RLLF+ A    P+ IF DEID
Sbjct: 256 MLAKAVATECG-----TTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEID 310

Query: 509 GLAPVR-SSRQDQIHSSIVSTLLALMDGL-------DNRGEIVVIGATNRLDSIDPALRR 560
            +   R +S + +    + S LL  MDG+       D    ++V+ ATN    ID ALRR
Sbjct: 311 SICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR 370

Query: 561 PGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEA 620
             R ++     LP  K R  +L+I+ R+      D  L ++AEK  GY GADI  +C +A
Sbjct: 371 --RLEKRIYIPLPTAKGRAELLKINLREVELD-PDIQLEDIAEKIEGYSGADITNVCRDA 427

Query: 621 ALIALRRR 628
           +L+A+RRR
Sbjct: 428 SLMAMRRR 435


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  139 bits (349), Expect = 3e-32
 Identities = 130/454 (28%), Positives = 205/454 (45%), Gaps = 63/454 (13%)

Query: 212 GEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSYGIQNHHEVSTEGEEEESQE-EDGDI 270
           GE ER+R++    FE + +  R+    K+ ++         E + E  ++  +E E G  
Sbjct: 111 GEAERVRVFHKQAFEYISIALRIDEDEKAGQK---------EQAVEWYKKGIEELEKGIA 161

Query: 271 EVEEAEGEENDRPYNLRQRKTV------DRYQA-----------PPIVPAHQKKRENTLF 313
            +   +GE+ +R   L+ +         DR Q            P    ++   R  T+ 
Sbjct: 162 VIVTGQGEQCERARRLQAKMMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVM 221

Query: 314 DI--------HRSPARR--SHIRRKKHAIHSSDTTSSDEERFER--RKSKSMARARNRCL 361
                     HR+P+    S +   K     + TT     +  R  + S      R +  
Sbjct: 222 KTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKD 281

Query: 362 PMNFRAED--LASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFP 419
             NFR  D  LA+ I+ E V  G +            V+FD I G      AL+E+V+ P
Sbjct: 282 LKNFRNVDSNLANLIMNEIVDNGTA------------VKFDDIAGQDLAKQALQEIVILP 329

Query: 420 LLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKW 479
            L PE+F   +  P RG L +GPPG GKT++A+A+A E +       FF    A   SK+
Sbjct: 330 SLRPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAAESN-----ATFFNISAASLTSKY 383

Query: 480 VGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNR 539
           VGE E+ +R LF  A  ++PSIIF DE+D L   R   +      + +  L   DG+ + 
Sbjct: 384 VGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSA 443

Query: 540 GE--IVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAF 597
           G+  ++V+GATNR   +D A+ R  RF +    +LP+++ R  +L+         L+   
Sbjct: 444 GDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKE 501

Query: 598 LGELAEKCVGYCGADIKALCTEAALIALRRRYPQ 631
           L +LA    GY G+D+ AL  +AAL  +R   P+
Sbjct: 502 LAQLARMTDGYSGSDLTALAKDAALGPIRELKPE 535


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  137 bits (344), Expect = 1e-31
 Identities = 83/232 (35%), Positives = 124/232 (53%), Gaps = 10/232 (4%)

Query: 397 VRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 456
           V ++ I G+      +KE+VV+P+L P+IF   +  PP+G L +GPPGTGKTL+ + +A+
Sbjct: 398 VNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTGKTLIGKCIAS 456

Query: 457 ECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS 516
           +         FF    +   SKWVGE E+ +R LF  A   +P++IF DEID L   R  
Sbjct: 457 QSG-----ATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGD 511

Query: 517 RQDQIHSSIVSTLLALMDGLDNRGE--IVVIGATNRLDSIDPALRRPGRFDREFLFNLPD 574
            + +    I +  L  +DG     E  I+V+GATNR   ID A RR  R  +     LP+
Sbjct: 512 GEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPE 569

Query: 575 QKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALR 626
             ARK I+          LS+  + ++ ++   + GAD+  LC EA+L  +R
Sbjct: 570 ASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIR 621


>gi|112789543 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  137 bits (344), Expect = 1e-31
 Identities = 83/232 (35%), Positives = 124/232 (53%), Gaps = 10/232 (4%)

Query: 397 VRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 456
           V ++ I G+      +KE+VV+P+L P+IF   +  PP+G L +GPPGTGKTL+ + +A+
Sbjct: 398 VNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTGKTLIGKCIAS 456

Query: 457 ECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS 516
           +         FF    +   SKWVGE E+ +R LF  A   +P++IF DEID L   R  
Sbjct: 457 QSG-----ATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGD 511

Query: 517 RQDQIHSSIVSTLLALMDGLDNRGE--IVVIGATNRLDSIDPALRRPGRFDREFLFNLPD 574
            + +    I +  L  +DG     E  I+V+GATNR   ID A RR  R  +     LP+
Sbjct: 512 GEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPE 569

Query: 575 QKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALR 626
             ARK I+          LS+  + ++ ++   + GAD+  LC EA+L  +R
Sbjct: 570 ASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIR 621


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score =  136 bits (343), Expect = 1e-31
 Identities = 106/324 (32%), Positives = 159/324 (49%), Gaps = 28/324 (8%)

Query: 316 HRSPARR--SHIRRKKHAIHSSDTTSSDEERFER--RKSKSMARARNRCLPMNFRAED-- 369
           HR+P+    S +   K     + TT     +  R  + S      R +    NFR  D  
Sbjct: 264 HRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSN 323

Query: 370 LASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKF 429
           LA+ I+ E V  G +            V+FD I G      AL+E+V+ P L PE+F   
Sbjct: 324 LANLIMNEIVDNGTA------------VKFDDIAGQDLAKQALQEIVILPSLRPELFTGL 371

Query: 430 KIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRL 489
           +  P RG L +GPPG GKT++A+A+A E +       FF    A   SK+VGE E+ +R 
Sbjct: 372 RA-PARGLLLFGPPGNGKTMLAKAVAAESN-----ATFFNISAASLTSKYVGEGEKLVRA 425

Query: 490 LFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGE--IVVIGA 547
           LF  A  ++PSIIF DE+D L   R   +      + +  L   DG+ + G+  ++V+GA
Sbjct: 426 LFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGA 485

Query: 548 TNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVG 607
           TNR   +D A+ R  RF +    +LP+++ R  +L+         L+   L +LA    G
Sbjct: 486 TNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDG 543

Query: 608 YCGADIKALCTEAALIALRRRYPQ 631
           Y G+D+ AL  +AAL  +R   P+
Sbjct: 544 YSGSDLTALAKDAALGPIRELKPE 567


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,641,050
Number of Sequences: 37866
Number of extensions: 2766453
Number of successful extensions: 16459
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 187
Number of HSP's successfully gapped in prelim test: 295
Number of HSP's that attempted gapping in prelim test: 13869
Number of HSP's gapped (non-prelim): 2211
length of query: 1458
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1343
effective length of database: 13,892,928
effective search space: 18658202304
effective search space used: 18658202304
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.