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Search of human proteins with 13994151
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13994151 PDZ and LIM domain 1 [Homo sapiens]
(329 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13994151 PDZ and LIM domain 1 [Homo sapiens] 671 0.0
gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens] 342 3e-94
gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens] 308 4e-84
gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens] 264 7e-71
gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens] 198 6e-51
gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens] 172 5e-43
gi|196162711 PDZ and LIM domain 4 isoform 2 [Homo sapiens] 149 4e-36
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens] 129 5e-30
gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens] 128 6e-30
gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens] 124 1e-28
gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens] 123 3e-28
gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens] 120 2e-27
gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens] 117 1e-26
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens] 117 1e-26
gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens] 114 2e-25
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens] 114 2e-25
gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens] 108 7e-24
gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens] 105 4e-23
gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens] 105 4e-23
gi|193083191 synaptopodin 2 isoform c [Homo sapiens] 71 1e-12
gi|193083185 synaptopodin 2 isoform b [Homo sapiens] 71 1e-12
gi|193083183 synaptopodin 2 isoform a [Homo sapiens] 71 1e-12
gi|166706868 synaptopodin 2-like isoform a [Homo sapiens] 60 3e-09
gi|4502175 apical protein of Xenopus-like [Homo sapiens] 57 3e-08
gi|118600967 shroom family member 4 [Homo sapiens] 49 6e-06
gi|203098098 shroom family member 3 protein [Homo sapiens] 49 6e-06
gi|14249622 ajuba isoform 1 [Homo sapiens] 45 7e-05
gi|170932518 paxillin isoform 3 [Homo sapiens] 45 9e-05
gi|170932516 paxillin isoform 2 [Homo sapiens] 45 9e-05
gi|170932514 paxillin isoform 1 [Homo sapiens] 45 9e-05
>gi|13994151 PDZ and LIM domain 1 [Homo sapiens]
Length = 329
Score = 671 bits (1731), Expect = 0.0
Identities = 329/329 (100%), Positives = 329/329 (100%)
Query: 1 MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN 60
MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN
Sbjct: 1 MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN 60
Query: 61 MTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAH 120
MTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAH
Sbjct: 61 MTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAH 120
Query: 121 NRSAMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLD 180
NRSAMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLD
Sbjct: 121 NRSAMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLD 180
Query: 181 HAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSV 240
HAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSV
Sbjct: 181 HAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSV 240
Query: 241 KAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFF 300
KAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFF
Sbjct: 241 KAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFF 300
Query: 301 VEDQIYCEKHARERVTPPEGYEVVTVFPK 329
VEDQIYCEKHARERVTPPEGYEVVTVFPK
Sbjct: 301 VEDQIYCEKHARERVTPPEGYEVVTVFPK 329
>gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens]
Length = 316
Score = 342 bits (877), Expect = 3e-94
Identities = 170/326 (52%), Positives = 218/326 (66%), Gaps = 13/326 (3%)
Query: 4 QQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTH 63
Q + L GP PWGFRL GG DF QPL I+R+TPGSKAA ANLC GDVI AIDG T +MTH
Sbjct: 3 QTVILPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESMTH 62
Query: 64 LEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRS 123
+AQ+RIK L L + R E +WSP V+E+GK HP+K+NL SEPQE IG+AHNR
Sbjct: 63 ADAQDRIKAAAHQLCLKIDRGETHLWSPQVSEDGKAHPFKINLESEPQEFKPIGTAHNRR 122
Query: 124 AMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQ 183
A PF A+ +V++ YN+P GLYS+ NI + A G P
Sbjct: 123 AQPFVAAANIDDKRQVVSASYNSPIGLYSTSNIQD---------ALHGQLRGLIPSSPQN 173
Query: 184 PPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAP 243
P++ V ES+VY+ML + + P+QS SF VLQ +++ G ++P+G RSV+AP
Sbjct: 174 EPTASV-PPESDVYRMLHDNRNEPTQPRQSGSFRVLQGMVDD---GSDDRPAGTRSVRAP 229
Query: 244 VTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVED 303
VTKV G AQ++P+CDKCG+GIVG VK RD++RHPEC+VC DC NLKQKG+FF+E
Sbjct: 230 VTKVHGGSGGAQRMPLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFIEG 289
Query: 304 QIYCEKHARERVTPPEGYEVVTVFPK 329
++YCE HAR R PPEGY+ VT++PK
Sbjct: 290 ELYCETHARARTKPPEGYDTVTLYPK 315
>gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens]
Length = 364
Score = 308 bits (789), Expect = 4e-84
Identities = 164/373 (43%), Positives = 219/373 (58%), Gaps = 59/373 (15%)
Query: 4 QQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTH 63
Q + L GP PWGFRL GG DF QPL I+R+TPGSKAA ANLC GDVI AIDG T +MTH
Sbjct: 3 QTVILPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESMTH 62
Query: 64 LEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRS 123
+AQ+RIK L L + R E +WSP V+E+GK HP+K+NL SEPQ+ + HN
Sbjct: 63 ADAQDRIKAAAHQLCLKIDRGETHLWSPQVSEDGKAHPFKINLESEPQDGNYFEHKHNIR 122
Query: 124 AMPFT--------------------ASPASSTT--------------------------- 136
PF ++P+S +T
Sbjct: 123 PKPFVIPGRSSGCSTPSGIDCGSGRSTPSSVSTVSTICPGDLKVAAKLAPNIPLEMELPG 182
Query: 137 ARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQPPSSLVIDKESEV 196
+++ Q+N P LYS +NI +E+ PL ++P +S + ES+V
Sbjct: 183 VKIVHAQFNTPMQLYSDDNI------METLQGQVSTALGETPL-MSEPTAS--VPPESDV 233
Query: 197 YKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAASIGNAQK 256
Y+ML + + P+QS SF VLQ +++ G ++P+G RSV+APVTKV G AQ+
Sbjct: 234 YRMLHDNRNEPTQPRQSGSFRVLQGMVDD---GSDDRPAGTRSVRAPVTKVHGGSGGAQR 290
Query: 257 LPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVT 316
+P+CDKCG+GIVG VK RD++RHPEC+VC DC NLKQKG+FF+E ++YCE HAR R
Sbjct: 291 MPLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFIEGELYCETHARARTK 350
Query: 317 PPEGYEVVTVFPK 329
PPEGY+ VT++PK
Sbjct: 351 PPEGYDTVTLYPK 363
>gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens]
Length = 330
Score = 264 bits (675), Expect = 7e-71
Identities = 147/330 (44%), Positives = 197/330 (59%), Gaps = 18/330 (5%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
+ L+GP PWGFRLVGG+DF PL ISRV GSKAALA LC GD+I AI+GE+T MTHLE
Sbjct: 5 VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64
Query: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSAM 125
AQNRIKGC D+LTL+V+R E + W P ++ K +++++ E Q+ + S
Sbjct: 65 AQNRIKGCHDHLTLSVSRPEGRSW-PSAPDDSKAQAHRIHIDPEIQD-----GSPTTSRR 118
Query: 126 PFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQPP 185
P + + Y P N S+ E+ A + P A P
Sbjct: 119 PSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSS-----EATLPAQMSTLHVSPPPSADPA 173
Query: 186 SSLV------IDKESEVYKMLQEKQE-LNEPPKQSTSFLVLQEILESEEKGDPNKPSGFR 238
L +D SEVY+ML+E E + PKQS SF LQ +LE+ E GD P G R
Sbjct: 174 RGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPR 233
Query: 239 SVKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGH 298
++K +K+ A + Q LP C +CG GIVG VK RD+ HPEC++C+DCG NLKQ+G+
Sbjct: 234 NLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGY 293
Query: 299 FFVEDQIYCEKHARERVTPPEGYEVVTVFP 328
FF+++++YCE HA+ RV PPEGY+VV V+P
Sbjct: 294 FFLDERLYCESHAKARVKPPEGYDVVAVYP 323
>gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens]
Length = 352
Score = 198 bits (503), Expect = 6e-51
Identities = 127/348 (36%), Positives = 189/348 (54%), Gaps = 42/348 (12%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
+D+ GP PWGFR+ GG+DF P+ +++V KA A+L GD+I AI+GE+ M H E
Sbjct: 5 VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAE 64
Query: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTE------------EGKRHPYKMNLASEPQEV 113
AQ++I+ L L + RS+ SP T +G Y + +S
Sbjct: 65 AQSKIRQSPSPLRLQLDRSQ--ATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSY 122
Query: 114 LHIGSAHNRSAMPFTASPASS--TTARVITNQYNNPA---GLYSSENISNFNNALESKTA 168
S R+ PF+ P+SS T I+ + + A GL +++ +S ++ S+ A
Sbjct: 123 SSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLS-YSGRPGSRQA 181
Query: 169 ASGVEANSRPLDHAQPPS---------------SLVIDKESEVYKMLQEKQELNEPPKQS 213
G +S L PPS SL++D++SEV+KMLQE +E P+QS
Sbjct: 182 GLGRAGDSAVL--VLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQS 239
Query: 214 TSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAAS--IGNAQKLPMCDKCGTGIVGVF 271
+SF +LQE LE+EE+G P+ S +P + + AS + KL C+KC T I
Sbjct: 240 SSFRLLQEALEAEERG--GTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQA 297
Query: 272 VKLRD-RHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTPP 318
V++++ R+RHP CY C DCG NLK +GHF+V D++YCEKHAR+R + P
Sbjct: 298 VRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAP 345
>gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens]
Length = 366
Score = 172 bits (435), Expect = 5e-43
Identities = 116/330 (35%), Positives = 174/330 (52%), Gaps = 42/330 (12%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
+D+ GP PWGFR+ GG+DF P+ +++V KA A+L GD+I AI+GE+ M H E
Sbjct: 5 VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAE 64
Query: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTE------------EGKRHPYKMNLASEPQEV 113
AQ++I+ L L + RS+ SP T +G Y + +S
Sbjct: 65 AQSKIRQSPSPLRLQLDRSQ--ATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSY 122
Query: 114 LHIGSAHNRSAMPFTASPASS--TTARVITNQYNNPA---GLYSSENISNFNNALESKTA 168
S R+ PF+ P+SS T I+ + + A GL +++ +S ++ S+ A
Sbjct: 123 SSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLS-YSGRPGSRQA 181
Query: 169 ASGVEANSRPLDHAQPPS---------------SLVIDKESEVYKMLQEKQELNEPPKQS 213
G +S L PPS SL++D++SEV+KMLQE +E P+QS
Sbjct: 182 GLGRAGDSAVL--VLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQS 239
Query: 214 TSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAAS--IGNAQKLPMCDKCGTGIVGVF 271
+SF +LQE LE+EE+G P+ S +P + + AS + KL C+KC T I
Sbjct: 240 SSFRLLQEALEAEERG--GTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQA 297
Query: 272 VKLRD-RHRHPECYVCTDCGTNLKQKGHFF 300
V++++ R+RHP CY C DCG NLK +GHF+
Sbjct: 298 VRIQEGRYRHPGCYTCADCGLNLKMRGHFW 327
>gi|196162711 PDZ and LIM domain 4 isoform 2 [Homo sapiens]
Length = 246
Score = 149 bits (375), Expect = 4e-36
Identities = 98/241 (40%), Positives = 129/241 (53%), Gaps = 18/241 (7%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
+ L+GP PWGFRLVGG+DF PL ISRV GSKAALA LC GD+I AI+GE+T MTHLE
Sbjct: 5 VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64
Query: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSAM 125
AQNRIKGC D+LTL+V+R E + W P ++ K +++++ E Q+ + S
Sbjct: 65 AQNRIKGCHDHLTLSVSRPEGRSW-PSAPDDSKAQAHRIHIDPEIQD-----GSPTTSRR 118
Query: 126 PFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQPP 185
P + + Y P N S+ E+ A + P A P
Sbjct: 119 PSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSS-----EATLPAQMSTLHVSPPPSADPA 173
Query: 186 SSLV------IDKESEVYKMLQEKQE-LNEPPKQSTSFLVLQEILESEEKGDPNKPSGFR 238
L +D SEVY+ML+E E + PKQS SF LQ +LE+ E G P+ G
Sbjct: 174 RGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGAPSSRHGTS 233
Query: 239 S 239
S
Sbjct: 234 S 234
>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
Length = 617
Score = 129 bits (323), Expect = 5e-30
Identities = 96/292 (32%), Positives = 134/292 (45%), Gaps = 52/292 (17%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
+ L GPGPWGFRL GGKDF PL ISR+TPGSKAA + L GD++ AIDG NT MTHLE
Sbjct: 5 VTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLE 64
Query: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSAM 125
AQN+IK + NL+LT+ +S+ + P+ T P + L P + + + S N
Sbjct: 65 AQNKIKSASYNLSLTLQKSKRPI--PIST---TAPPVQTPLPVIPHQKVVVNSPANADYQ 119
Query: 126 ----PFTASPASSTT------------ARVITNQYNNPAGLYSSENISNFNNALESKTAA 169
P ++ +T A +I QYN P +YS + I + A
Sbjct: 120 ERFNPSALKDSALSTHKPIEVKGLGGKATIIHAQYNTPISMYSQDAIMD--------AIA 171
Query: 170 SGVEANSRPLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPK----------QSTSFLVL 219
+A + P L +D S VY+ + + Q E QS SF +L
Sbjct: 172 GQAQAQGSDFSGSLPIKDLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRIL 231
Query: 220 QEILESEEKGDPNKPSGFRS-------------VKAPVTKVAASIGNAQKLP 258
++ +E DP++ + RS AP T + S G A P
Sbjct: 232 AQMTGTEFMQDPDEEALRRSRPQASSYSPAVAASSAPATHTSYSEGPAAPAP 283
Score = 48.9 bits (115), Expect = 6e-06
Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 23/188 (12%)
Query: 124 AMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQ 183
A +T SPA + T + +PA Y+ N+N A V + P + A
Sbjct: 324 APAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYN-------PAPSVAYSGGPAEPAS 376
Query: 184 PPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAP 243
P + D S+ + P +ST+ + Q + P P +
Sbjct: 377 RPPWVTDDSFSQKFA-----------PGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGT 425
Query: 244 VTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVED 303
V + A + + P+C C I G F+ R HPE + C C T+L FVE+
Sbjct: 426 VQR-AERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADV--CFVEE 482
Query: 304 Q--IYCEK 309
Q +YCE+
Sbjct: 483 QNNVYCER 490
Score = 35.8 bits (81), Expect = 0.054
Identities = 16/52 (30%), Positives = 23/52 (44%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEK 309
P+C KC T I+G + + H C+VC C + + YCEK
Sbjct: 498 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEK 549
Score = 32.3 bits (72), Expect = 0.60
Identities = 12/41 (29%), Positives = 22/41 (53%)
Query: 271 FVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHA 311
F++ H C++C C NL+ + + +D+ C+KHA
Sbjct: 572 FIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 612
>gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]
Length = 283
Score = 128 bits (322), Expect = 6e-30
Identities = 89/260 (34%), Positives = 126/260 (48%), Gaps = 39/260 (15%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
+ L GPGPWGFRL GGKDF PL ISR+TPGSKAA + L GD++ AIDG NT MTHLE
Sbjct: 5 VTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLE 64
Query: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSAM 125
AQN+IK + NL+LT+ +S+ + P+ T P + L P + + + S N
Sbjct: 65 AQNKIKSASYNLSLTLQKSKRPI--PIST---TAPPVQTPLPVIPHQKVVVNSPANADYQ 119
Query: 126 ----PFTASPASSTT------------ARVITNQYNNPAGLYSSENISNFNNALESKTAA 169
P ++ +T A +I QYN P +YS + I + A
Sbjct: 120 ERFNPSALKDSALSTHKPIEVKGLGGKATIIHAQYNTPISMYSQDAIMD--------AIA 171
Query: 170 SGVEANSRPLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPK----------QSTSFLVL 219
+A + P L +D S VY+ + + Q E QS SF +L
Sbjct: 172 GQAQAQGSDFSGSLPIKDLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRIL 231
Query: 220 QEILESEEKGDPNKPSGFRS 239
++ +E DP++ + RS
Sbjct: 232 AQMTGTEFMQDPDEEALRRS 251
>gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]
Length = 457
Score = 124 bits (311), Expect = 1e-28
Identities = 96/338 (28%), Positives = 147/338 (43%), Gaps = 40/338 (11%)
Query: 1 MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN 60
M + ++ L+GP PWGFRL GGKDF PL+ISR+TPG KAA A + +GD + +IDGEN +
Sbjct: 1 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
Query: 61 MTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAH 120
+TH+EAQN+I+ C + L+L ++R++ + K A P+ +
Sbjct: 61 LTHIEAQNKIRACGERLSLGLSRAQ--------PVQSKPQKASAPAADPPRYTFAPSVSL 112
Query: 121 NRSAMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLD 180
N++A PF A P + + + Q P +S+ N +G + R L
Sbjct: 113 NKTARPFGAPPPADSAPQQ-NGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILA 171
Query: 181 H------AQPPSSLVIDKESEVYKMLQEKQELNEP-----------PKQSTSFLVLQEIL 223
H Q P + K S+V + + P P + V
Sbjct: 172 HLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFA 231
Query: 224 ES----------EEKGDPNKPSGFRS----VKAPVTKVAASIGNAQKLPMCDKCGTGIVG 269
E P P+ +S V+A V N K P+C +C I G
Sbjct: 232 ERYAPDKTSTVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRG 291
Query: 270 VFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYC 307
++ HPE +VC+ CG L++ G F + I+C
Sbjct: 292 RYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFC 329
Score = 36.6 bits (83), Expect = 0.032
Identities = 15/52 (28%), Positives = 22/52 (42%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEK 309
P C KC I G + H C+ C C T ++ + + E YCE+
Sbjct: 339 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCER 390
Score = 32.0 bits (71), Expect = 0.78
Identities = 13/36 (36%), Positives = 19/36 (52%)
Query: 280 HPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERV 315
H C+VC C NL+ K + +D+ C+ HA V
Sbjct: 422 HDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV 457
>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
Length = 423
Score = 123 bits (308), Expect = 3e-28
Identities = 92/315 (29%), Positives = 142/315 (45%), Gaps = 28/315 (8%)
Query: 1 MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN 60
M + ++ L+GP PWGFRL GGKDF PL+ISR+TPG KAA A + +GD + +IDGEN +
Sbjct: 1 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
Query: 61 MTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAH 120
+TH+EAQN+I+ C + L+L ++R++ P + + P + + ++ L + +
Sbjct: 61 LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTPDKQPLRPLVPDASKQRL-MENTE 119
Query: 121 NRSAMPFTASPASSTTARVITN----QYNNPAGLYSSENISNFNNALESKTAASGVEANS 176
+ P T S +T Q + L S + E+ AS
Sbjct: 120 DWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPR----TEAPAPASSTPQEP 175
Query: 177 RPLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSG 236
P A P+S + + E P K ST P P+
Sbjct: 176 WPGPTAPSPTS------RPPWAVDPAFAERYAPDKTSTVL---------TRHSQPATPTP 220
Query: 237 FRS----VKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTN 292
+S V+A V N K P+C +C I G ++ HPE +VC+ CG
Sbjct: 221 LQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKV 280
Query: 293 LKQKGHFFVEDQIYC 307
L++ G F + I+C
Sbjct: 281 LEEGGFFEEKGAIFC 295
Score = 36.6 bits (83), Expect = 0.032
Identities = 15/52 (28%), Positives = 22/52 (42%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEK 309
P C KC I G + H C+ C C T ++ + + E YCE+
Sbjct: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCER 356
Score = 32.0 bits (71), Expect = 0.78
Identities = 13/36 (36%), Positives = 19/36 (52%)
Query: 280 HPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERV 315
H C+VC C NL+ K + +D+ C+ HA V
Sbjct: 388 HDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV 423
>gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens]
Length = 278
Score = 120 bits (301), Expect = 2e-27
Identities = 87/256 (33%), Positives = 132/256 (51%), Gaps = 37/256 (14%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
+D+ GP PWGFR+ GG+DF P+ +++V KA A+L GD+I AI+GE+ M H E
Sbjct: 5 VDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAE 64
Query: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTE------------EGKRHPYKMNLASEPQEV 113
AQ++I+ L L + RS+ SP T +G Y + +S
Sbjct: 65 AQSKIRQSPSPLRLQLDRSQ--ATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSY 122
Query: 114 LHIGSAHNRSAMPFTASPASS--TTARVITNQYNNPA---GLYSSENISNFNNALESKTA 168
S R+ PF+ P+SS T I+ + + A GL +++ +S ++ S+ A
Sbjct: 123 SSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLS-YSGRPGSRQA 181
Query: 169 ASGVEANSRPLDHAQPPS---------------SLVIDKESEVYKMLQEKQELNEPPKQS 213
G +S L PPS SL++D++SEV+KMLQE +E P+QS
Sbjct: 182 GLGRAGDSAVL--VLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQS 239
Query: 214 TSFLVLQEILESEEKG 229
+SF +LQE LE+EE+G
Sbjct: 240 SSFRLLQEALEAEERG 255
>gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens]
Length = 330
Score = 117 bits (293), Expect = 1e-26
Identities = 95/301 (31%), Positives = 132/301 (43%), Gaps = 74/301 (24%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
+ L GPGPWGFRL GGKDF PL ISR+TPGSKAA + L GD++ AIDG NT MTHLE
Sbjct: 5 VTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLE 64
Query: 66 AQNRIKGCTDNLT---------LTVARSEHKVWSPLVTEEGKRHPYKMNLAS------EP 110
AQN+IK + NL+ + ++ + V +PL ++ P S P
Sbjct: 65 AQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAPSPSP 124
Query: 111 QEVLHIGSAHNRSAMPFTASPASS------------------TTARVITN---------- 142
+ G+ P T SPA S + R T+
Sbjct: 125 EARASPGTPGTPELRP-TFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDLLGP 183
Query: 143 ----------QYNNPAGLYSSENISN----FNNALESKTAASGVEANSRPLDHAQPPSSL 188
QYNNP GLYS+E + + +L K + G+ S P+ L
Sbjct: 184 KALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPI------KDL 237
Query: 189 VIDKESEVYKMLQEKQELNEPPK----------QSTSFLVLQEILESEEKGDPNKPSGFR 238
+D S VY+ + + Q E QS SF +L ++ +E DP++ + R
Sbjct: 238 AVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRR 297
Query: 239 S 239
S
Sbjct: 298 S 298
>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
Length = 727
Score = 117 bits (293), Expect = 1e-26
Identities = 95/301 (31%), Positives = 132/301 (43%), Gaps = 74/301 (24%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
+ L GPGPWGFRL GGKDF PL ISR+TPGSKAA + L GD++ AIDG NT MTHLE
Sbjct: 5 VTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLE 64
Query: 66 AQNRIKGCTDNLT---------LTVARSEHKVWSPLVTEEGKRHPYKMNLAS------EP 110
AQN+IK + NL+ + ++ + V +PL ++ P S P
Sbjct: 65 AQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAPSPSP 124
Query: 111 QEVLHIGSAHNRSAMPFTASPASS------------------TTARVITN---------- 142
+ G+ P T SPA S + R T+
Sbjct: 125 EARASPGTPGTPELRP-TFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDLLGP 183
Query: 143 ----------QYNNPAGLYSSENISN----FNNALESKTAASGVEANSRPLDHAQPPSSL 188
QYNNP GLYS+E + + +L K + G+ S P+ L
Sbjct: 184 KALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPI------KDL 237
Query: 189 VIDKESEVYKMLQEKQELNEPPK----------QSTSFLVLQEILESEEKGDPNKPSGFR 238
+D S VY+ + + Q E QS SF +L ++ +E DP++ + R
Sbjct: 238 AVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRR 297
Query: 239 S 239
S
Sbjct: 298 S 298
Score = 48.9 bits (115), Expect = 6e-06
Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 23/188 (12%)
Query: 124 AMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQ 183
A +T SPA + T + +PA Y+ N+N A V + P + A
Sbjct: 434 APAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYN-------PAPSVAYSGGPAEPAS 486
Query: 184 PPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAP 243
P + D S+ + P +ST+ + Q + P P +
Sbjct: 487 RPPWVTDDSFSQKFA-----------PGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGT 535
Query: 244 VTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVED 303
V + A + + P+C C I G F+ R HPE + C C T+L FVE+
Sbjct: 536 VQR-AERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADV--CFVEE 592
Query: 304 Q--IYCEK 309
Q +YCE+
Sbjct: 593 QNNVYCER 600
Score = 35.8 bits (81), Expect = 0.054
Identities = 16/52 (30%), Positives = 23/52 (44%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEK 309
P+C KC T I+G + + H C+VC C + + YCEK
Sbjct: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEK 659
Score = 32.3 bits (72), Expect = 0.60
Identities = 12/41 (29%), Positives = 22/41 (53%)
Query: 271 FVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHA 311
F++ H C++C C NL+ + + +D+ C+KHA
Sbjct: 682 FIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 722
>gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]
Length = 487
Score = 114 bits (284), Expect = 2e-25
Identities = 105/359 (29%), Positives = 144/359 (40%), Gaps = 51/359 (14%)
Query: 1 MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN 60
M+ + L GP PWGFRL GGKDF PL IS + G KAA AN+ IGDV+ +IDG N
Sbjct: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
Query: 61 MTHLEAQNRIKGCTDNLTLTVARSEH-------KVWSPLVTE----------EGKRH--- 100
MTHLEAQN+IKGCT +L +T+ R+ V P VT EG+R
Sbjct: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKPTVTSVCSETSQELAEGQRRGSQ 120
Query: 101 --------PYKMNLASEPQEVLHIGSAHNRSAMPFTAS-----PASSTT---ARVITNQY 144
P + ++ E H+ + + S P + TT + I Q
Sbjct: 121 GDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQI 180
Query: 145 NNPAGLYSSE--NISNFNNALE--SKTAASGVEANSRPLDHAQPPS---SLVIDKESEVY 197
L SE N NN+ E + A+S S P P S + + +
Sbjct: 181 TGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAF 240
Query: 198 KMLQEKQELNEP----PKQS--TSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKV--AA 249
K + + P P Q ++ + S N G T V A
Sbjct: 241 KPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAE 300
Query: 250 SIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCE 308
I ++ PMC C I G F+ + HPE + C C + G + +YCE
Sbjct: 301 HIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCE 359
Score = 35.8 bits (81), Expect = 0.054
Identities = 14/51 (27%), Positives = 23/51 (45%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCE 308
P C +C I+G + + H C+VC CG ++ + + YCE
Sbjct: 368 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCE 418
Score = 31.2 bits (69), Expect = 1.3
Identities = 12/32 (37%), Positives = 20/32 (62%)
Query: 280 HPECYVCTDCGTNLKQKGHFFVEDQIYCEKHA 311
H C+VC+ C +L+ + F +D+ C+KHA
Sbjct: 451 HDTCFVCSVCCESLEGQTFFSKKDKPLCKKHA 482
>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
Length = 596
Score = 114 bits (284), Expect = 2e-25
Identities = 82/236 (34%), Positives = 116/236 (49%), Gaps = 16/236 (6%)
Query: 1 MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN 60
M+ + L GP PWGFRL GGKDF PL IS + G KAA AN+ IGDV+ +IDG N
Sbjct: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
Query: 61 MTHLEAQNRIKGCTDNLTLTVAR-SEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGS- 118
MTHLEAQN+IKGCT +L +T+ R S P+ ++G+ + V + S
Sbjct: 61 MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTST 120
Query: 119 ---AHNRSAMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKT--AASGVE 173
A+N++ PF + + T+ + PA +S + S A + AASG+
Sbjct: 121 NNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLH 180
Query: 174 ANSRPLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKG 229
AN+ L Q PS+L K + +P S QE+ E + +G
Sbjct: 181 ANAN-LSADQSPSALSAGKTA--------VNVPRQPTVTSVCSETSQELAEGQRRG 227
Score = 35.8 bits (81), Expect = 0.054
Identities = 14/51 (27%), Positives = 23/51 (45%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCE 308
P C +C I+G + + H C+VC CG ++ + + YCE
Sbjct: 477 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCE 527
Score = 35.4 bits (80), Expect = 0.070
Identities = 18/61 (29%), Positives = 26/61 (42%)
Query: 248 AASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYC 307
A I ++ PMC C I G F+ + HPE + C C + G + +YC
Sbjct: 408 AEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYC 467
Query: 308 E 308
E
Sbjct: 468 E 468
Score = 31.2 bits (69), Expect = 1.3
Identities = 12/32 (37%), Positives = 20/32 (62%)
Query: 280 HPECYVCTDCGTNLKQKGHFFVEDQIYCEKHA 311
H C+VC+ C +L+ + F +D+ C+KHA
Sbjct: 560 HDTCFVCSVCCESLEGQTFFSKKDKPLCKKHA 591
>gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens]
Length = 222
Score = 108 bits (270), Expect = 7e-24
Identities = 54/135 (40%), Positives = 82/135 (60%), Gaps = 8/135 (5%)
Query: 1 MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN 60
M + ++ L+GP PWGFRL GGKDF PL+ISR+TPG KAA A + +GD + +IDGEN +
Sbjct: 1 MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
Query: 61 MTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAH 120
+TH+EAQN+I+ C + L+L ++R++ + K A P+ +
Sbjct: 61 LTHIEAQNKIRACGERLSLGLSRAQ--------PVQSKPQKASAPAADPPRYTFAPSVSL 112
Query: 121 NRSAMPFTASPASST 135
N++A PF A P + +
Sbjct: 113 NKTARPFGAPPPADS 127
>gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]
Length = 214
Score = 105 bits (263), Expect = 4e-23
Identities = 49/84 (58%), Positives = 60/84 (71%)
Query: 1 MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN 60
M+ + L GP PWGFRL GGKDF PL IS + G KAA AN+ IGDV+ +IDG N
Sbjct: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
Query: 61 MTHLEAQNRIKGCTDNLTLTVARS 84
MTHLEAQN+IKGCT +L +T+ R+
Sbjct: 61 MTHLEAQNKIKGCTGSLNMTLQRA 84
>gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]
Length = 234
Score = 105 bits (263), Expect = 4e-23
Identities = 49/84 (58%), Positives = 60/84 (71%)
Query: 1 MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN 60
M+ + L GP PWGFRL GGKDF PL IS + G KAA AN+ IGDV+ +IDG N
Sbjct: 1 MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60
Query: 61 MTHLEAQNRIKGCTDNLTLTVARS 84
MTHLEAQN+IKGCT +L +T+ R+
Sbjct: 61 MTHLEAQNKIKGCTGSLNMTLQRA 84
>gi|193083191 synaptopodin 2 isoform c [Homo sapiens]
Length = 1109
Score = 71.2 bits (173), Expect = 1e-12
Identities = 47/169 (27%), Positives = 80/169 (47%), Gaps = 4/169 (2%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
I + G PWGFRL GGK+ +QPL ++++ SKA+ + LC GD + +I+G +++T+ E
Sbjct: 9 ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
Query: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTE-EGKRHPYKMNLASEPQEVLHIGSAHNRSA 124
++ TD+L + + R + L++E E K + + L I A
Sbjct: 69 VIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQC 128
Query: 125 MPFTASPASSTTARVITNQYNNP--AGLYSSENISNFNNALESKTAASG 171
F +P T + NQ + P AG E ++ A + + G
Sbjct: 129 TEFFLAPV-KTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRG 176
>gi|193083185 synaptopodin 2 isoform b [Homo sapiens]
Length = 1093
Score = 71.2 bits (173), Expect = 1e-12
Identities = 47/169 (27%), Positives = 80/169 (47%), Gaps = 4/169 (2%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
I + G PWGFRL GGK+ +QPL ++++ SKA+ + LC GD + +I+G +++T+ E
Sbjct: 9 ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
Query: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTE-EGKRHPYKMNLASEPQEVLHIGSAHNRSA 124
++ TD+L + + R + L++E E K + + L I A
Sbjct: 69 VIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQC 128
Query: 125 MPFTASPASSTTARVITNQYNNP--AGLYSSENISNFNNALESKTAASG 171
F +P T + NQ + P AG E ++ A + + G
Sbjct: 129 TEFFLAPV-KTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRG 176
>gi|193083183 synaptopodin 2 isoform a [Homo sapiens]
Length = 1261
Score = 71.2 bits (173), Expect = 1e-12
Identities = 47/169 (27%), Positives = 80/169 (47%), Gaps = 4/169 (2%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
I + G PWGFRL GGK+ +QPL ++++ SKA+ + LC GD + +I+G +++T+ E
Sbjct: 9 ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
Query: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTE-EGKRHPYKMNLASEPQEVLHIGSAHNRSA 124
++ TD+L + + R + L++E E K + + L I A
Sbjct: 69 VIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQC 128
Query: 125 MPFTASPASSTTARVITNQYNNP--AGLYSSENISNFNNALESKTAASG 171
F +P T + NQ + P AG E ++ A + + G
Sbjct: 129 TEFFLAPV-KTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRG 176
>gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
Length = 977
Score = 59.7 bits (143), Expect = 3e-09
Identities = 34/88 (38%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
+ L G PWGFRL GG + +PL +S++ S+A A L D + AI+G + +N++H
Sbjct: 9 VTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTNLSHAS 68
Query: 66 AQNRIKGCTDNLTLTVAR--SEHKVWSP 91
A + I + L LTV R E V SP
Sbjct: 69 AMSLIDASGNQLVLTVQRLADEGPVQSP 96
>gi|4502175 apical protein of Xenopus-like [Homo sapiens]
Length = 1616
Score = 56.6 bits (135), Expect = 3e-08
Identities = 55/194 (28%), Positives = 84/194 (43%), Gaps = 31/194 (15%)
Query: 5 QIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALAN-LCIGDVITAIDGENTSNMTH 63
++ L G PWGF L GG++ +PL I+++ GSKAA + L GD I I+ S
Sbjct: 28 EVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQ 87
Query: 64 LEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRS 123
EA +KG L L V R W P H + S+ L +
Sbjct: 88 -EAICLVKGSHKTLKLVVKRRSELGWRP--------HSWHATKFSDSHPEL--------A 130
Query: 124 AMPFTAS---PASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLD 180
A PFT++ P+ S ++ ++ L SS +N L+ ++ V++ LD
Sbjct: 131 ASPFTSTSGCPSWSGRHHASSSSHD----LSSSWEQTNLQRTLDHFSSLGSVDS----LD 182
Query: 181 HAQPPSSLVIDKES 194
H P S L + K +
Sbjct: 183 H--PSSRLSVAKSN 194
>gi|118600967 shroom family member 4 [Homo sapiens]
Length = 1493
Score = 48.9 bits (115), Expect = 6e-06
Identities = 33/87 (37%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALA-NLCIGDVITAIDGENTSNMTHL 64
+ LQG PWGF L GG + +PL +S++ G KAAL+ + GD + I+G +
Sbjct: 13 VQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVNINGTPLYG-SRQ 71
Query: 65 EAQNRIKGCTDNLTLTVARSEHKVWSP 91
EA IKG L L V R V P
Sbjct: 72 EALILIKGSFRILKLIVRRRNAPVSRP 98
>gi|203098098 shroom family member 3 protein [Homo sapiens]
Length = 1996
Score = 48.9 bits (115), Expect = 6e-06
Identities = 40/119 (33%), Positives = 55/119 (46%), Gaps = 12/119 (10%)
Query: 8 LQGPGPWGFRLVGGKDFEQPLAISRVTPGSKA--ALANLCIGDVITAIDGENTSNMTHLE 65
L+G PWGF L GG + +PL IS+V G KA + L GD + I+ E T + + E
Sbjct: 32 LEGGAPWGFTLKGGLEHGEPLIISKVEEGGKADTLSSKLQAGDEVVHIN-EVTLSSSRKE 90
Query: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSA 124
A + +KG L L V R + T+ G N S E L G H ++A
Sbjct: 91 AVSLVKGSYKTLRLVVRRD-------VCTDPGHADTGASNFVS--PEHLTSGPQHRKAA 140
>gi|14249622 ajuba isoform 1 [Homo sapiens]
Length = 538
Score = 45.4 bits (106), Expect = 7e-05
Identities = 28/96 (29%), Positives = 40/96 (41%), Gaps = 10/96 (10%)
Query: 224 ESEEKGDPN--KPSGFRSVKAPVTKVAASI------GNAQKLPMCDKCGTGIVGVF--VK 273
E+ +G+P+ +PSG P AA C KC GI G +
Sbjct: 294 EAGARGEPSGIEPSGLEEPPGPFVPEAARARMREPEAREDYFGTCIKCNKGIYGQSNACQ 353
Query: 274 LRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEK 309
D H +C+VC CG L+ K + V +YCE+
Sbjct: 354 ALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEE 389
Score = 29.6 bits (65), Expect = 3.9
Identities = 23/77 (29%), Positives = 30/77 (38%), Gaps = 13/77 (16%)
Query: 258 PMCDKCGTGIVG-------VFVKLRDRHRHPECYVCTDCGTNLKQKGH---FFVEDQIYC 307
P C CG I+ V V DR H ECY C DC L + F ++ + C
Sbjct: 461 PKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLC 520
Query: 308 EKHARERVT---PPEGY 321
+R+ PP Y
Sbjct: 521 HGCHMQRLNARQPPANY 537
>gi|170932518 paxillin isoform 3 [Homo sapiens]
Length = 424
Score = 45.1 bits (105), Expect = 9e-05
Identities = 20/57 (35%), Positives = 27/57 (47%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARER 314
P C C I+ ++ + HPEC+VC +C T F + Q YCE H ER
Sbjct: 307 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHER 363
Score = 40.0 bits (92), Expect = 0.003
Identities = 28/99 (28%), Positives = 42/99 (42%), Gaps = 10/99 (10%)
Query: 225 SEEKGDPNKP-----SGFRSVKAPVTKVA-ASIGNAQKLPMCDKCGTGIVGVFVKLRDRH 278
S G P KP S S+++ + K+ A++ +C C I G V +
Sbjct: 154 SSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKG----VCGACKKPIAGQVVTAMGKT 209
Query: 279 RHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTP 317
HPE +VCT C + + F + Q YCEK +P
Sbjct: 210 WHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSP 248
Score = 36.6 bits (83), Expect = 0.032
Identities = 19/63 (30%), Positives = 25/63 (39%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTP 317
P C C I+ V DR HPE + C CG +G + + YC K + P
Sbjct: 248 PRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAP 307
Query: 318 PEG 320
G
Sbjct: 308 KCG 310
Score = 28.5 bits (62), Expect = 8.6
Identities = 14/50 (28%), Positives = 21/50 (42%)
Query: 259 MCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCE 308
+C C I G + + HPE +VC C L + D+ YC+
Sbjct: 367 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQ 416
>gi|170932516 paxillin isoform 2 [Homo sapiens]
Length = 557
Score = 45.1 bits (105), Expect = 9e-05
Identities = 20/57 (35%), Positives = 27/57 (47%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARER 314
P C C I+ ++ + HPEC+VC +C T F + Q YCE H ER
Sbjct: 440 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHER 496
Score = 40.0 bits (92), Expect = 0.003
Identities = 28/99 (28%), Positives = 42/99 (42%), Gaps = 10/99 (10%)
Query: 225 SEEKGDPNKP-----SGFRSVKAPVTKVA-ASIGNAQKLPMCDKCGTGIVGVFVKLRDRH 278
S G P KP S S+++ + K+ A++ +C C I G V +
Sbjct: 287 SSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKG----VCGACKKPIAGQVVTAMGKT 342
Query: 279 RHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTP 317
HPE +VCT C + + F + Q YCEK +P
Sbjct: 343 WHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSP 381
Score = 36.6 bits (83), Expect = 0.032
Identities = 19/63 (30%), Positives = 25/63 (39%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTP 317
P C C I+ V DR HPE + C CG +G + + YC K + P
Sbjct: 381 PRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAP 440
Query: 318 PEG 320
G
Sbjct: 441 KCG 443
Score = 28.5 bits (62), Expect = 8.6
Identities = 14/50 (28%), Positives = 21/50 (42%)
Query: 259 MCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCE 308
+C C I G + + HPE +VC C L + D+ YC+
Sbjct: 500 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQ 549
>gi|170932514 paxillin isoform 1 [Homo sapiens]
Length = 591
Score = 45.1 bits (105), Expect = 9e-05
Identities = 20/57 (35%), Positives = 27/57 (47%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARER 314
P C C I+ ++ + HPEC+VC +C T F + Q YCE H ER
Sbjct: 474 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHER 530
Score = 40.0 bits (92), Expect = 0.003
Identities = 28/99 (28%), Positives = 42/99 (42%), Gaps = 10/99 (10%)
Query: 225 SEEKGDPNKP-----SGFRSVKAPVTKVA-ASIGNAQKLPMCDKCGTGIVGVFVKLRDRH 278
S G P KP S S+++ + K+ A++ +C C I G V +
Sbjct: 321 SSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKG----VCGACKKPIAGQVVTAMGKT 376
Query: 279 RHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTP 317
HPE +VCT C + + F + Q YCEK +P
Sbjct: 377 WHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSP 415
Score = 36.6 bits (83), Expect = 0.032
Identities = 19/63 (30%), Positives = 25/63 (39%)
Query: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTP 317
P C C I+ V DR HPE + C CG +G + + YC K + P
Sbjct: 415 PRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAP 474
Query: 318 PEG 320
G
Sbjct: 475 KCG 477
Score = 28.5 bits (62), Expect = 8.6
Identities = 14/50 (28%), Positives = 21/50 (42%)
Query: 259 MCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCE 308
+C C I G + + HPE +VC C L + D+ YC+
Sbjct: 534 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQ 583
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,585,910
Number of Sequences: 37866
Number of extensions: 611771
Number of successful extensions: 3295
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 168
Number of HSP's successfully gapped in prelim test: 192
Number of HSP's that attempted gapping in prelim test: 2455
Number of HSP's gapped (non-prelim): 1011
length of query: 329
length of database: 18,247,518
effective HSP length: 103
effective length of query: 226
effective length of database: 14,347,320
effective search space: 3242494320
effective search space used: 3242494320
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.