Search of human proteins with 7019569

Search of human proteins with 7019569

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
         (437 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]          874   0.0  
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]         723   0.0  
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               253   3e-67
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               253   3e-67
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     248   6e-66
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]              243   3e-64
gi|40806170 spastin isoform 2 [Homo sapiens]                          227   2e-59
gi|11875211 spastin isoform 1 [Homo sapiens]                          227   2e-59
gi|31742536 fidgetin-like 1 [Homo sapiens]                            225   5e-59
gi|112789543 fidgetin-like 1 [Homo sapiens]                           225   5e-59
gi|64084766 fidgetin [Homo sapiens]                                   167   2e-41
gi|6005942 valosin-containing protein [Homo sapiens]                  164   1e-40
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     160   2e-39
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              158   1e-38
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   149   4e-36
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     149   6e-36
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 144   2e-34
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 144   2e-34
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            140   2e-33
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            140   3e-33
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           137   1e-32
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           135   7e-32
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            135   1e-31
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       134   2e-31
gi|4505725 peroxin1 [Homo sapiens]                                    134   2e-31
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   128   9e-30
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   128   9e-30
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   128   9e-30
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                      128   9e-30
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                       128   9e-30

>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
          Length = 437

 Score =  874 bits (2258), Expect = 0.0
 Identities = 437/437 (100%), Positives = 437/437 (100%)

Query: 1   MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKC 60
           MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKC
Sbjct: 1   MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKC 60

Query: 61  VQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVME 120
           VQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVME
Sbjct: 61  VQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVME 120

Query: 121 KPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAV 180
           KPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAV
Sbjct: 121 KPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAV 180

Query: 181 ATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENE 240
           ATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENE
Sbjct: 181 ATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENE 240

Query: 241 SEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARA 300
           SEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARA
Sbjct: 241 SEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARA 300

Query: 301 QMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCG 360
           QMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCG
Sbjct: 301 QMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCG 360

Query: 361 PSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNA 420
           PSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNA
Sbjct: 361 PSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNA 420

Query: 421 DDLLKVKKFSEDFGQES 437
           DDLLKVKKFSEDFGQES
Sbjct: 421 DDLLKVKKFSEDFGQES 437


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score =  723 bits (1865), Expect = 0.0
 Identities = 356/440 (80%), Positives = 403/440 (91%), Gaps = 5/440 (1%)

Query: 2   TTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCV 61
           T+  LQKAIDL +KA +EDKA NYEEAL+LYQHAV+YFLH +KYEA  DKAK+SIRAKC 
Sbjct: 4   TSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCT 63

Query: 62  QYLDRAEKLKDYLRSKEKHGKKPVKENQ---SEGKGSDSDSEG--DNPEKKKLQEQLMGA 116
           +YLDRAEKLK+YL++KEK  +KPVKE Q   ++ KG+DSD EG  D+PEKKKLQ QL GA
Sbjct: 64  EYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGA 123

Query: 117 VVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYL 176
           +V+E+PN++W+DVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYL
Sbjct: 124 IVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYL 183

Query: 177 AKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR 236
           AKAVATEANNSTFFS+SSSDL+SKWLGESEKLVKNLF+LAR++KPSIIFIDE+DSLCGSR
Sbjct: 184 AKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR 243

Query: 237 NENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEE 296
           +ENESEAARRIKTEFLVQMQGVG +NDG LVLGATNIPWVLDSAIRRRFEKRIYIPLPE 
Sbjct: 244 SENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEP 303

Query: 297 AARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFK 356
            ARA MF+LHLG+T ++LT+A+  EL RKT+GYSGADISIIVRD+LMQPVRKVQSATHFK
Sbjct: 304 HARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFK 363

Query: 357 KVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRP 416
           KV GPSR +P+ ++DDLLTPCSPGDPGA+EMTWMDVPGDKLLEPVV MSDMLRSL+ T+P
Sbjct: 364 KVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSNTKP 423

Query: 417 TVNADDLLKVKKFSEDFGQE 436
           TVN  DLLK+KKF+EDFGQE
Sbjct: 424 TVNEHDLLKLKKFTEDFGQE 443


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  253 bits (645), Expect = 3e-67
 Identities = 138/286 (48%), Positives = 193/286 (67%), Gaps = 13/286 (4%)

Query: 71  KDY-LRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDV 129
           KDY  R ++  G+K +++  S+G+    D  G +   K L E L   +V   P+I W+D+
Sbjct: 154 KDYRARGRDDKGRKNMQDGASDGEMPKFDGAGYD---KDLVEALERDIVSRNPSIHWDDI 210

Query: 130 AGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTF 189
           A LE AK+ L+EAV+LP+  P  F G R PW+G+L+ GPPGTGK+ LAKAVATE   +TF
Sbjct: 211 ADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATEC-GTTF 269

Query: 190 FSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR-NENESEAARRIK 248
           F+VSSS L SK+ GESEKLV+ LFE+AR + P+ IFIDE+DS+C  R   +E EA+RR+K
Sbjct: 270 FNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVK 329

Query: 249 TEFLVQMQGVG---NNNDGT---LVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQM 302
           +E L+QM GVG    N+D +   +VL ATN PW +D A+RRR EKRIYIPLP    RA++
Sbjct: 330 SELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAEL 389

Query: 303 FRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRK 348
            +++L     +  D  + ++A K EGYSGADI+ + RD+ +  +R+
Sbjct: 390 LKINLREVELD-PDIQLEDIAEKIEGYSGADITNVCRDASLMAMRR 434


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  253 bits (645), Expect = 3e-67
 Identities = 138/286 (48%), Positives = 193/286 (67%), Gaps = 13/286 (4%)

Query: 71  KDY-LRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDV 129
           KDY  R ++  G+K +++  S+G+    D  G +   K L E L   +V   P+I W+D+
Sbjct: 154 KDYRARGRDDKGRKNMQDGASDGEMPKFDGAGYD---KDLVEALERDIVSRNPSIHWDDI 210

Query: 130 AGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTF 189
           A LE AK+ L+EAV+LP+  P  F G R PW+G+L+ GPPGTGK+ LAKAVATE   +TF
Sbjct: 211 ADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATEC-GTTF 269

Query: 190 FSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR-NENESEAARRIK 248
           F+VSSS L SK+ GESEKLV+ LFE+AR + P+ IFIDE+DS+C  R   +E EA+RR+K
Sbjct: 270 FNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVK 329

Query: 249 TEFLVQMQGVG---NNNDGT---LVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQM 302
           +E L+QM GVG    N+D +   +VL ATN PW +D A+RRR EKRIYIPLP    RA++
Sbjct: 330 SELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAEL 389

Query: 303 FRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRK 348
            +++L     +  D  + ++A K EGYSGADI+ + RD+ +  +R+
Sbjct: 390 LKINLREVELD-PDIQLEDIAEKIEGYSGADITNVCRDASLMAMRR 434


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  248 bits (634), Expect = 6e-66
 Identities = 138/296 (46%), Positives = 185/296 (62%), Gaps = 15/296 (5%)

Query: 66  RAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIR 125
           R  + K+  + +E+  K P    + E    DS         K L E L   ++ + PN+R
Sbjct: 153 RCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYD-----KDLVEALERDIISQNPNVR 207

Query: 126 WNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEAN 185
           W+D+A L  AK+ LKEAV+LP+  P  F G R PW+G+L+ GPPGTGK+ LAKAVATE  
Sbjct: 208 WDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATEC- 266

Query: 186 NSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENES-EAA 244
            +TFF+VSSS L SK+ GESEKLV+ LFE+AR + P+ IFIDE+DS+C  R  +E  EA+
Sbjct: 267 KTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEAS 326

Query: 245 RRIKTEFLVQMQGVGNNNDG------TLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAA 298
           RR+K E LVQM GVG  ++        +VL ATN PW +D A+RRR EKRIYIPLP    
Sbjct: 327 RRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKG 386

Query: 299 RAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRD-SLMQPVRKVQSAT 353
           R ++ R+ L        D ++  +A   EGYSGADI+ + RD SLM   R+++  T
Sbjct: 387 REELLRISLREL-ELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLT 441


>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score =  243 bits (619), Expect = 3e-64
 Identities = 124/260 (47%), Positives = 176/260 (67%), Gaps = 9/260 (3%)

Query: 101 GDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPW 160
           G N E ++L   +   + +  PNI+WND+ GL+ AK+ +KEAV+ PI++P LFTG  +PW
Sbjct: 156 GMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPW 215

Query: 161 RGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHK 220
           +G+LL+GPPGTGK+ LAKAVATE   +TFF++S+S ++SKW G+SEKLV+ LFELAR H 
Sbjct: 216 KGLLLYGPPGTGKTLLAKAVATEC-KTTFFNISASTIVSKWRGDSEKLVRVLFELARYHA 274

Query: 221 PSIIFIDEVDSLC---GSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVL 277
           PS IF+DE++S+    G+ +  E E + R+KTE LVQM G+  + D   VL A+N+PW L
Sbjct: 275 PSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWEL 334

Query: 278 DSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNL-----TDANIHELARKTEGYSGA 332
           D A+ RR EKRI + LP   AR  M    L     +      T+     L+++TEGYSG+
Sbjct: 335 DCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGS 394

Query: 333 DISIIVRDSLMQPVRKVQSA 352
           DI ++ R++ M+PVRK+  A
Sbjct: 395 DIKLVCREAAMRPVRKIFDA 414


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  227 bits (578), Expect = 2e-59
 Identities = 119/243 (48%), Positives = 170/243 (69%), Gaps = 2/243 (0%)

Query: 109 LQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGP 168
           L   +M  +V     ++++D+AG + AK+AL+E VILP   P LFTG R P RG+LLFGP
Sbjct: 292 LANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGP 351

Query: 169 PGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDE 228
           PG GK+ LAKAVA E+N +TFF++S++ L SK++GE EKLV+ LF +AR+ +PSIIFIDE
Sbjct: 352 PGNGKTMLAKAVAAESN-ATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDE 410

Query: 229 VDSLCGSRNENESEAARRIKTEFLVQMQGVGN-NNDGTLVLGATNIPWVLDSAIRRRFEK 287
           VDSL   R E E +A+RR+KTEFL++  GV +  +D  LV+GATN P  LD A+ RRF K
Sbjct: 411 VDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIK 470

Query: 288 RIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVR 347
           R+Y+ LP E  R  + +  L      LT   + +LAR T+GYSG+D++ + +D+ + P+R
Sbjct: 471 RVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR 530

Query: 348 KVQ 350
           +++
Sbjct: 531 ELK 533


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score =  227 bits (578), Expect = 2e-59
 Identities = 119/243 (48%), Positives = 170/243 (69%), Gaps = 2/243 (0%)

Query: 109 LQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGP 168
           L   +M  +V     ++++D+AG + AK+AL+E VILP   P LFTG R P RG+LLFGP
Sbjct: 324 LANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGP 383

Query: 169 PGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDE 228
           PG GK+ LAKAVA E+N +TFF++S++ L SK++GE EKLV+ LF +AR+ +PSIIFIDE
Sbjct: 384 PGNGKTMLAKAVAAESN-ATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDE 442

Query: 229 VDSLCGSRNENESEAARRIKTEFLVQMQGVGN-NNDGTLVLGATNIPWVLDSAIRRRFEK 287
           VDSL   R E E +A+RR+KTEFL++  GV +  +D  LV+GATN P  LD A+ RRF K
Sbjct: 443 VDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIK 502

Query: 288 RIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVR 347
           R+Y+ LP E  R  + +  L      LT   + +LAR T+GYSG+D++ + +D+ + P+R
Sbjct: 503 RVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR 562

Query: 348 KVQ 350
           +++
Sbjct: 563 ELK 565


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  225 bits (574), Expect = 5e-59
 Identities = 112/246 (45%), Positives = 171/246 (69%), Gaps = 2/246 (0%)

Query: 108 KLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFG 167
           K+ E +M  ++   P + W D+AG+E AK  +KE V+ P+  P +FTG R P +GILLFG
Sbjct: 382 KMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFG 441

Query: 168 PPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFID 227
           PPGTGK+ + K +A+++  +TFFS+S+S L SKW+GE EK+V+ LF +AR  +P++IFID
Sbjct: 442 PPGTGKTLIGKCIASQSG-ATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFID 500

Query: 228 EVDSLCGSRNENESEAARRIKTEFLVQMQG-VGNNNDGTLVLGATNIPWVLDSAIRRRFE 286
           E+DSL   R + E E++RRIKTEFLVQ+ G   ++ D  LV+GATN P  +D A RRR  
Sbjct: 501 EIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLV 560

Query: 287 KRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPV 346
           KR+YIPLPE +AR Q+    +      L++  I ++ ++++ +SGAD++ + R++ + P+
Sbjct: 561 KRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPI 620

Query: 347 RKVQSA 352
           R +Q+A
Sbjct: 621 RSLQTA 626


>gi|112789543 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  225 bits (574), Expect = 5e-59
 Identities = 112/246 (45%), Positives = 171/246 (69%), Gaps = 2/246 (0%)

Query: 108 KLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFG 167
           K+ E +M  ++   P + W D+AG+E AK  +KE V+ P+  P +FTG R P +GILLFG
Sbjct: 382 KMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFG 441

Query: 168 PPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFID 227
           PPGTGK+ + K +A+++  +TFFS+S+S L SKW+GE EK+V+ LF +AR  +P++IFID
Sbjct: 442 PPGTGKTLIGKCIASQSG-ATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFID 500

Query: 228 EVDSLCGSRNENESEAARRIKTEFLVQMQG-VGNNNDGTLVLGATNIPWVLDSAIRRRFE 286
           E+DSL   R + E E++RRIKTEFLVQ+ G   ++ D  LV+GATN P  +D A RRR  
Sbjct: 501 EIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLV 560

Query: 287 KRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPV 346
           KR+YIPLPE +AR Q+    +      L++  I ++ ++++ +SGAD++ + R++ + P+
Sbjct: 561 KRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPI 620

Query: 347 RKVQSA 352
           R +Q+A
Sbjct: 621 RSLQTA 626


>gi|64084766 fidgetin [Homo sapiens]
          Length = 759

 Score =  167 bits (422), Expect = 2e-41
 Identities = 91/251 (36%), Positives = 150/251 (59%), Gaps = 4/251 (1%)

Query: 117 VVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYL 176
           ++ + P + WND+AGL+  K  +KE V+ P+     F+G     R ILLFGP GTGK+ L
Sbjct: 476 IITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLL 535

Query: 177 AKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR 236
            + +A++   +TFF ++ S L++KWLGE+EK++   F +AR  +PS+IF+ ++D L  S+
Sbjct: 536 GRCIASQLG-ATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQ 594

Query: 237 NENESEAARRIKTEFLVQMQGV-GNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPE 295
              E     R++TEFL+Q+  V  +  D  +V+ AT+ P  +D ++RR F KR+ IPLP+
Sbjct: 595 VNEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMKRLLIPLPD 654

Query: 296 EAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHF 355
             AR Q+    L    + L D     L ++TEG+SG D++ + +++++ P+     AT  
Sbjct: 655 STARHQIIVQLLSQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAVVGPLH-AMPATDL 713

Query: 356 KKVCGPSRTNP 366
             +  PS+  P
Sbjct: 714 SAIM-PSQLRP 723


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  164 bits (415), Expect = 1e-40
 Identities = 95/259 (36%), Positives = 152/259 (58%), Gaps = 13/259 (5%)

Query: 118 VMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWRGILLFGPPGTGKSYL 176
           V+E P + W D+ GLE  K  L+E V  P++ P  F     TP +G+L +GPPG GK+ L
Sbjct: 468 VVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLL 527

Query: 177 AKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR 236
           AKA+A E   + F S+   +L++ W GESE  V+ +F+ ARQ  P ++F DE+DS+  +R
Sbjct: 528 AKAIANECQ-ANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKAR 586

Query: 237 NENESE---AARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYI 291
             N  +   AA R+  + L +M G+    +   ++GATN P ++D AI R  R ++ IYI
Sbjct: 587 GGNIGDGGGAADRVINQILTEMDGMSTKKN-VFIIGATNRPDIIDPAILRPGRLDQLIYI 645

Query: 292 PLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRK-VQ 350
           PLP+E +R  + + +L  +P    D ++  LA+ T G+SGAD++ I + +    +R+ ++
Sbjct: 646 PLPDEKSRVAILKANLRKSP-VAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIE 704

Query: 351 SATHFKKVCGPSRTNPSMM 369
           S    ++     +TNPS M
Sbjct: 705 SEIRRER---ERQTNPSAM 720



 Score =  153 bits (386), Expect = 3e-37
 Identities = 99/310 (31%), Positives = 166/310 (53%), Gaps = 13/310 (4%)

Query: 124 IRWNDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYLAKAVA 181
           + ++D+ G       +KE V LP++ P LF   G + P RGILL+GPPGTGK+ +A+AVA
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPP-RGILLYGPPGTGKTLIARAVA 259

Query: 182 TEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENES 241
            E   + FF ++  ++MSK  GESE  ++  FE A ++ P+IIFIDE+D++   R +   
Sbjct: 260 NETG-AFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHG 318

Query: 242 EAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEEAAR 299
           E  RRI ++ L  M G+       +V+ ATN P  +D A+RR  RF++ + I +P+   R
Sbjct: 319 EVERRIVSQLLTLMDGL-KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGR 377

Query: 300 AQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVC 359
            ++ ++H         D ++ ++A +T G+ GAD++ +  ++ +Q +RK       +   
Sbjct: 378 LEILQIHT-KNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET 436

Query: 360 GPSRTNPSMMI--DDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSL--ATTR 415
             +    S+ +  DD     S  +P A+  T ++VP     E +  + D+ R L      
Sbjct: 437 IDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVP-QVTWEDIGGLEDVKRELQELVQY 495

Query: 416 PTVNADDLLK 425
           P  + D  LK
Sbjct: 496 PVEHPDKFLK 505


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  160 bits (405), Expect = 2e-39
 Identities = 93/234 (39%), Positives = 143/234 (61%), Gaps = 5/234 (2%)

Query: 123 NIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRT--PWRGILLFGPPGTGKSYLAKAV 180
           ++ W+D+AGL+     LK+ VILPIK  HLF   R   P +G+LL+GPPG GK+ +AKA 
Sbjct: 87  HVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKAT 146

Query: 181 ATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENE 240
           A EA    F ++  S L  KW GES+KL   +F LA + +PSIIFIDE+DS   +R+ ++
Sbjct: 147 AKEAG-CRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSD 205

Query: 241 SEAARRIKTEFLVQMQGVGNNND-GTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAAR 299
            EA   +K +F+    G+  ++    +V+GATN P  LDSAI RR   R +I  P    R
Sbjct: 206 HEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQR 265

Query: 300 AQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSAT 353
             + +L L +   +    ++ E+A++T+G+SG+D+  + RD+ +  VR+  ++T
Sbjct: 266 EAILKLILKNENVD-RHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNST 318


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  158 bits (399), Expect = 1e-38
 Identities = 100/279 (35%), Positives = 156/279 (55%), Gaps = 15/279 (5%)

Query: 124 IRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPW-RGILLFGPPGTGKSYLAKAVAT 182
           + ++ + GL    +A++E + LP+K P LF     P  RG+LL+GPPGTGK+ +A+AVA 
Sbjct: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409

Query: 183 EANNSTFFSV-SSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENES 241
           E     + SV +  +++SK+ GE+E  ++ +F  A    PSIIFIDE+D+LC  R   ++
Sbjct: 410 EVG--AYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQN 467

Query: 242 EAARRIKTEFLVQMQGVGN--NNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEEA 297
           E  +R+    L  M G+G+  +    LVLGATN P  LD+A+RR  RF+K I I +P   
Sbjct: 468 EVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQ 527

Query: 298 ARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKV---QSATH 354
            R  + +  L   PH LT+A + +LA    GY GAD+ ++  ++ +  +R++   Q    
Sbjct: 528 DRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLP 587

Query: 355 FKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVP 393
             KV G  +    + + D L   +   P AM    +DVP
Sbjct: 588 DVKVAGLVK----ITLKDFLQAMNDIRPSAMREIAIDVP 622



 Score =  156 bits (394), Expect = 4e-38
 Identities = 88/240 (36%), Positives = 143/240 (59%), Gaps = 8/240 (3%)

Query: 109 LQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFG 167
           ++   M  + ++ PN+ W+D+ GLE  K  L++AV  P+K P  F      P +G+LL+G
Sbjct: 609 IRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYG 668

Query: 168 PPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFID 227
           PPG  K+ +AKA+A E+  + F ++   +LM+K++GESE+ V+  F  AR   PSIIF D
Sbjct: 669 PPGCSKTMIAKALANESGLN-FLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFD 727

Query: 228 EVDSLCGSRNEN--ESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR-- 283
           E+D+L   R  +      A R+  + L +M G+    D T +L ATN P  +D A+ R  
Sbjct: 728 ELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVT-ILAATNRPDRIDKALMRPG 786

Query: 284 RFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLM 343
           R ++ IY+PLP+ A R ++F+L   S P +  + ++ EL  +T+ YSGA+I  + R++ +
Sbjct: 787 RIDRIIYVPLPDAATRREIFKLQFHSMPVS-NEVDLDELILQTDAYSGAEIVAVCREAAL 845


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  149 bits (377), Expect = 4e-36
 Identities = 85/233 (36%), Positives = 134/233 (57%), Gaps = 8/233 (3%)

Query: 123 NIRWNDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWRGILLFGPPGTGKSYLAKAVA 181
           ++R++ + GL     ALKE V+ P+ +P +F   K  P RG L +GPPGTGK+ +A+A+A
Sbjct: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455

Query: 182 TEANNS----TFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRN 237
            E +       FF    +D +SKW+GESE+ ++ LF+ A   +PSIIF DE+D L   R+
Sbjct: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515

Query: 238 ENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPE 295
             + +    I +  L  M G+ N  +  +V+GATN    +D A+RR  RF++     LP+
Sbjct: 516 SRQDQIHSSIVSTLLALMDGLDNRGE-IVVIGATNRLDSIDPALRRPGRFDREFLFNLPD 574

Query: 296 EAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRK 348
           + AR  + ++H       L+DA + ELA K  GY GADI  +  ++ +  +R+
Sbjct: 575 QKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRR 627


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  149 bits (375), Expect = 6e-36
 Identities = 99/313 (31%), Positives = 162/313 (51%), Gaps = 19/313 (6%)

Query: 44  KYEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDN 103
           ++  HS  +  S  ++  Q+ +R  K     R++  +   P+   + E KG   D     
Sbjct: 352 RHAIHSSDSTSSSSSEDEQHFERRRKRS---RNRAINRCLPLNFRKDELKGIYKD----- 403

Query: 104 PEKKKLQEQLMGAVVME-KPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWR 161
             + K+   L     M+   ++R++ V GL     ALKE V+ P+ +P +F   K  P R
Sbjct: 404 --RMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPR 461

Query: 162 GILLFGPPGTGKSYLAKAVATEANNS----TFFSVSSSDLMSKWLGESEKLVKNLFELAR 217
           G L +GPPGTGK+ +A+A+A E +       FF    +D +SKW+GESE+ ++ LF+ A 
Sbjct: 462 GCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAY 521

Query: 218 QHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVL 277
           Q +PSIIF DE+D L   R+  + +    I +  L  M G+ +  +  +V+GATN    +
Sbjct: 522 QMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGE-IVVIGATNRLDSI 580

Query: 278 DSAIRR--RFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADIS 335
           D A+RR  RF++     LP++ AR ++ ++H         D  + ELA    GY GADI 
Sbjct: 581 DPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIK 640

Query: 336 IIVRDSLMQPVRK 348
            I  ++ +  +R+
Sbjct: 641 SICAEAALCALRR 653


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  144 bits (362), Expect = 2e-34
 Identities = 85/235 (36%), Positives = 139/235 (59%), Gaps = 11/235 (4%)

Query: 122 PNIRWNDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYLAKA 179
           PN+ W D+  LE  +E L  A++ P++ P  F   G  TP  G+LL GPPG GK+ LAKA
Sbjct: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGKTLLAKA 528

Query: 180 VATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNEN 239
           VA E+  + F SV   +L++ ++GESE+ V+ +F+ A+   P +IF DEVD+LC  R++ 
Sbjct: 529 VANESGLN-FISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDR 587

Query: 240 ESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEEA 297
           E+ A+ R+  + L +M G+        ++ ATN P ++D AI R  R +K +++ LP  A
Sbjct: 588 ETGASVRVVNQLLTEMDGL-EARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPA 646

Query: 298 ARAQMFR--LHLGSTPHNLTDANIHELA--RKTEGYSGADISIIVRDSLMQPVRK 348
            R  + +     G+ P    D N+  +A   + + Y+GAD+S +VR++ +  +R+
Sbjct: 647 DRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ 701



 Score =  117 bits (293), Expect = 2e-26
 Identities = 105/325 (32%), Positives = 162/325 (49%), Gaps = 41/325 (12%)

Query: 74  LRSKEKHGKKPVKENQSEGKGS--DSD--------SEGDNPEKKKLQEQ--LMGAVVMEK 121
           L  ++ + KKP+ E Q     S  +SD        ++G   +K+ LQE    + AV+ +K
Sbjct: 84  LSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKK 143

Query: 122 P----------NIRWNDVAGLEGA-KEALKEAVIL--PIKFPHLFTGKRTPWRGILLFGP 168
                      N+++ DV G +   KE  K  + +  P  + HL      P RG+LL GP
Sbjct: 144 AKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGV---VPPRGVLLHGP 200

Query: 169 PGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDE 228
           PG GK+ LA A+A E +      V++ +++S   GESE+ ++ LFE A  + P IIFIDE
Sbjct: 201 PGCGKTLLAHAIAGELD-LPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDE 259

Query: 229 VDSLCGSRNENESEAARRIKTEFLVQMQGVGN--NNDGTLVLGATNIPWVLDSAIRR--R 284
           +D++   R     +  RRI  + L  M  + N       LV+GATN P  LD A+RR  R
Sbjct: 260 IDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGR 319

Query: 285 FEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDA-NIHELARKTEGYSGADISIIVRDSLM 343
           F++ I + +P+EA+R ++  L        L  A +   LA  T G+ GAD+  + R++ M
Sbjct: 320 FDREICLGIPDEASRERI--LQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAM 377

Query: 344 QPVRKVQSATHFKKVCGPSRTNPSM 368
             V +V       K+    + NP M
Sbjct: 378 CAVNRV-----LMKLQEQQKKNPEM 397


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  144 bits (362), Expect = 2e-34
 Identities = 85/235 (36%), Positives = 139/235 (59%), Gaps = 11/235 (4%)

Query: 122 PNIRWNDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYLAKA 179
           PN+ W D+  LE  +E L  A++ P++ P  F   G  TP  G+LL GPPG GK+ LAKA
Sbjct: 576 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGKTLLAKA 634

Query: 180 VATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNEN 239
           VA E+  + F SV   +L++ ++GESE+ V+ +F+ A+   P +IF DEVD+LC  R++ 
Sbjct: 635 VANESGLN-FISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDR 693

Query: 240 ESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEEA 297
           E+ A+ R+  + L +M G+        ++ ATN P ++D AI R  R +K +++ LP  A
Sbjct: 694 ETGASVRVVNQLLTEMDGL-EARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPA 752

Query: 298 ARAQMFR--LHLGSTPHNLTDANIHELA--RKTEGYSGADISIIVRDSLMQPVRK 348
            R  + +     G+ P    D N+  +A   + + Y+GAD+S +VR++ +  +R+
Sbjct: 753 DRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ 807



 Score =  117 bits (293), Expect = 2e-26
 Identities = 105/325 (32%), Positives = 162/325 (49%), Gaps = 41/325 (12%)

Query: 74  LRSKEKHGKKPVKENQSEGKGS--DSD--------SEGDNPEKKKLQEQ--LMGAVVMEK 121
           L  ++ + KKP+ E Q     S  +SD        ++G   +K+ LQE    + AV+ +K
Sbjct: 190 LSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKK 249

Query: 122 P----------NIRWNDVAGLEGA-KEALKEAVIL--PIKFPHLFTGKRTPWRGILLFGP 168
                      N+++ DV G +   KE  K  + +  P  + HL      P RG+LL GP
Sbjct: 250 AKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGV---VPPRGVLLHGP 306

Query: 169 PGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDE 228
           PG GK+ LA A+A E +      V++ +++S   GESE+ ++ LFE A  + P IIFIDE
Sbjct: 307 PGCGKTLLAHAIAGELD-LPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDE 365

Query: 229 VDSLCGSRNENESEAARRIKTEFLVQMQGVGN--NNDGTLVLGATNIPWVLDSAIRR--R 284
           +D++   R     +  RRI  + L  M  + N       LV+GATN P  LD A+RR  R
Sbjct: 366 IDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGR 425

Query: 285 FEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDA-NIHELARKTEGYSGADISIIVRDSLM 343
           F++ I + +P+EA+R ++  L        L  A +   LA  T G+ GAD+  + R++ M
Sbjct: 426 FDREICLGIPDEASRERI--LQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAM 483

Query: 344 QPVRKVQSATHFKKVCGPSRTNPSM 368
             V +V       K+    + NP M
Sbjct: 484 CAVNRV-----LMKLQEQQKKNPEM 503


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  140 bits (354), Expect = 2e-33
 Identities = 92/247 (37%), Positives = 147/247 (59%), Gaps = 14/247 (5%)

Query: 111 EQLMGAVVMEK-PNIRWNDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFG 167
           + L+  +++EK P+  +  + GL+   + +KE + LP+K P LF   G   P +G+LL+G
Sbjct: 132 DPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQP-KGVLLYG 190

Query: 168 PPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFID 227
           PPGTGK+ LA+AVA   +  TF  VS S+L+ K++GE  ++V+ LF +AR+H PSIIF+D
Sbjct: 191 PPGTGKTLLARAVAHHTD-CTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMD 249

Query: 228 EVDSLCGSRNENES---EAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR- 283
           E+DS+  SR E  S      +R   E L Q+ G     +  +++ ATN   +LDSA+ R 
Sbjct: 250 EIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIM-ATNRIDILDSALLRP 308

Query: 284 -RFEKRIYIPLPEEAARAQMFRLHLGSTPHNLT-DANIHELARKTEGYSGADISIIVRDS 341
            R +++I  P P E AR  + ++H  S   NLT   N+ ++A    G SGA++  +  ++
Sbjct: 309 GRIDRKIEFPPPNEEARLDILKIH--SRKMNLTRGINLRKIAELMPGASGAEVKGVCTEA 366

Query: 342 LMQPVRK 348
            M  +R+
Sbjct: 367 GMYALRE 373


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  140 bits (352), Expect = 3e-33
 Identities = 85/238 (35%), Positives = 140/238 (58%), Gaps = 11/238 (4%)

Query: 118 VMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSY 175
           V + P   + D+ GL+   + +KE+V LP+  P  +   G + P +G++L+GPPGTGK+ 
Sbjct: 176 VEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPP-KGVILYGPPGTGKTL 234

Query: 176 LAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGS 235
           LAKAVA + + +TF  V  S+L+ K+LG+  KLV+ LF +A +H PSI+FIDE+D++   
Sbjct: 235 LAKAVANQTS-ATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTK 293

Query: 236 RNENESEAARRIK---TEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIY 290
           R ++ S   R I+    E L Q+ G  +  D  +++ ATN    LD A+ R  R +++I 
Sbjct: 294 RYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIM-ATNRIETLDPALIRPGRIDRKIE 352

Query: 291 IPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRK 348
            PLP+E  + ++F++H  S      D  + +L    +  SGADI  I  ++ +  +R+
Sbjct: 353 FPLPDEKTKKRIFQIHT-SRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRE 409


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  137 bits (346), Expect = 1e-32
 Identities = 86/250 (34%), Positives = 141/250 (56%), Gaps = 27/250 (10%)

Query: 123 NIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFGPPGTGKSYLAKAVA 181
           N+ ++++ GL      L+E + LP+  P LF      P +G LL+GPPGTGK+ LA+AVA
Sbjct: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202

Query: 182 TEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENES 241
           ++ +   F  V SS ++ K++GES +L++ +F  AR H+P IIF+DE+D++ G R    +
Sbjct: 203 SQLD-CNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGT 261

Query: 242 EAARRIK---TEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEE 296
            A R I+    E L QM G    +   +++ ATN P  LD A+ R  R +++I+I LP E
Sbjct: 262 SADREIQRTLMELLNQMDGFDTLHRVKMIM-ATNRPDTLDPALLRPGRLDRKIHIDLPNE 320

Query: 297 AARAQMFRLHLGS-TPHNLTDANIHELARKTEGYSGADI----------------SIIVR 339
            AR  + ++H G  T H   + +   + + ++G++GAD+                  +V+
Sbjct: 321 QARLDILKIHAGPITKHG--EIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQ 378

Query: 340 DSLMQPVRKV 349
           +  M+ VRKV
Sbjct: 379 EDFMKAVRKV 388


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  135 bits (340), Expect = 7e-32
 Identities = 103/322 (31%), Positives = 162/322 (50%), Gaps = 54/322 (16%)

Query: 122 PNIRWNDVAGLEGAKEALKEAVILPIKFPHLFT-GKRTPWRGILLFGPPGTGKSYLAKAV 180
           P++ W+DV GL+  K+ + E + LP++ P L + G R    G+LL GPPGTGK+ LAKAV
Sbjct: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAV 757

Query: 181 ATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENE 240
           ATE +  TF SV   +L++ ++G+SE+ V+ +F  AR   P IIF DE+DSL  SR  + 
Sbjct: 758 ATECS-LTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSG 816

Query: 241 SEAA--RRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEE 296
                  R+ ++ L ++ G+ +  D   V+GATN P +LD A+ R  RF+K +++   E+
Sbjct: 817 DSGGVMDRVVSQLLAELDGLHSTQD-VFVIGATNRPDLLDPALLRPGRFDKLVFVGANED 875

Query: 297 AARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFK 356
             RA   R+                            +S I R   ++P     S  +  
Sbjct: 876 --RASQLRV----------------------------LSAITRKFKLEP---SVSLVNVL 902

Query: 357 KVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDV-----PGDKLLEPVVCMSDMLRSL 411
             C P  T       DL + CS     A++    D+     PG   L  ++ M D+L++ 
Sbjct: 903 DCCPPQLTGA-----DLYSLCSDAMTAALKRRVHDLEEGLEPGSSAL--MLTMEDLLQAA 955

Query: 412 ATTRPTVNADDLLKVKKFSEDF 433
           A  +P+V+  +LL+ K+    F
Sbjct: 956 ARLQPSVSEQELLRYKRIQRKF 977



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 41/190 (21%), Positives = 83/190 (43%), Gaps = 2/190 (1%)

Query: 163 ILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPS 222
           +LL GPPG GK+ +  A  +         V  S L ++  G  E  ++ +F  AR+ +P+
Sbjct: 466 VLLRGPPGCGKTTVVAAACSHL-GLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPA 524

Query: 223 IIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIR 282
           ++ +  VD L   R+    +A        L+  +   N+    +V+  T+    L + ++
Sbjct: 525 VLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQ 584

Query: 283 RRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSL 342
             F   + +P   E  R  + R      P    + N+ +LAR+  G+   D+  ++  S 
Sbjct: 585 TAFPHELEVPALSEGQRLSILRALTAHLPLG-QEVNLAQLARRCAGFVVGDLYALLTHSS 643

Query: 343 MQPVRKVQSA 352
                +++++
Sbjct: 644 RAACTRIKNS 653


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  135 bits (339), Expect = 1e-31
 Identities = 83/238 (34%), Positives = 140/238 (58%), Gaps = 11/238 (4%)

Query: 118 VMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFGPPGTGKSYL 176
           V E+P  +++D+ GL+   + L EA++LP+     F      P +G+L++GPPGTGK+ L
Sbjct: 177 VDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLL 236

Query: 177 AKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR 236
           A+A A +   +TF  ++   L+  ++G+  KLV++ F LA++  PSIIFIDE+D++   R
Sbjct: 237 ARACAAQTK-ATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKR 295

Query: 237 NENESEAARRIK---TEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYI 291
            ++E    R ++    E L Q+ G   N     V+ ATN   +LD A+ R  R +++I  
Sbjct: 296 FDSEKAGDREVQRTMLELLNQLDGFQPNTQ-VKVIAATNRVDILDPALLRSGRLDRKIEF 354

Query: 292 PLPEEAARAQMFRLHLGSTPHNLT-DANIHELARKTEGYSGADISIIVRDSLMQPVRK 348
           P+P E ARA++ ++H  S   N++ D N  ELAR T+ ++GA    +  ++ M  +R+
Sbjct: 355 PMPNEEARARIMQIH--SRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRR 410


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  134 bits (337), Expect = 2e-31
 Identities = 86/254 (33%), Positives = 142/254 (55%), Gaps = 29/254 (11%)

Query: 107 KKLQEQLMGAVV--MEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRG 162
           K +Q     +V+  M+   + W ++ GLE  K  LK+++  P+KFP  F   G   P +G
Sbjct: 442 KNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQP-KG 500

Query: 163 ILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPS 222
           +LL+GPPG  K+ L +A+AT  + S F SVS +DL S ++G+SEK++  +F  AR   P+
Sbjct: 501 VLLYGPPGCAKTTLVRALATSCHCS-FVSVSGADLFSPFVGDSEKVLSQIFRQARASTPA 559

Query: 223 IIFIDEVDSLCGSRNENES--EAARRIKTEFLVQMQGVGNN------------------N 262
           I+F+DE+DS+ G+R+ +++  +   R+ +  L ++ GVG                    N
Sbjct: 560 ILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFN 619

Query: 263 DGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIH 320
              +++ ATN P VLD+A+ R  R +K IYIP P+   R  + ++   + P    D ++ 
Sbjct: 620 RSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIG-PDVSLE 678

Query: 321 ELARKTEGYSGADI 334
            LA +T  +SGAD+
Sbjct: 679 NLAAETCFFSGADL 692



 Score =  119 bits (298), Expect = 5e-27
 Identities = 77/222 (34%), Positives = 127/222 (57%), Gaps = 13/222 (5%)

Query: 129 VAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYLAKAVATEANN 186
           + GL  A ++L+E + LP+++P   T  G   P RG+LL GPPG GK+ L +AVA EA  
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVP-RGVLLAGPPGVGKTQLVRAVAREA-G 259

Query: 187 STFFSVSSSDLMSKWLGESEKLVKNLFELARQ---HKPSIIFIDEVDSLCGSRNENESEA 243
           +   +VS+  L     GE+E+ V+ +F+ AR+     PS++F+DE+D+LC  R     E+
Sbjct: 260 AELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSRAPES 319

Query: 244 ARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEEAARAQ 301
             R+  + L  + G   + +  +V+GATN P  LD A+RR  RF++ + I  P    R +
Sbjct: 320 --RVVAQVLTLLDGASGDRE-VVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKE 376

Query: 302 MFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLM 343
           + ++     P + +  ++  LA  T GY GAD++ + R++ M
Sbjct: 377 ILQVITSKMPIS-SHVDLGLLAEMTVGYVGADLTALCREAAM 417


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  134 bits (337), Expect = 2e-31
 Identities = 77/233 (33%), Positives = 134/233 (57%), Gaps = 7/233 (3%)

Query: 116  AVVMEKP-NIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWR-GILLFGPPGTGK 173
            +V + KP ++ W+ + GL   ++ L + + LP K+P LF       R GILL+GPPGTGK
Sbjct: 828  SVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGK 887

Query: 174  SYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLC 233
            + LA  +A E +   F SV   +L+SK++G SE+ V+++F  A+  KP I+F DE +S+ 
Sbjct: 888  TLLAGVIARE-SRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIA 946

Query: 234  GSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYI 291
              R  + +    R+  + L Q+ GV     G  VL AT+ P ++D A+ R  R +K +Y 
Sbjct: 947  PRRGHDNTGVTDRVVNQLLTQLDGV-EGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYC 1005

Query: 292  PLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQ 344
            P P++ +R ++  +   S P    D ++  +A  T+ ++GAD+  ++ ++ ++
Sbjct: 1006 PPPDQVSRLEILNVLSDSLP-LADDVDLQHVASVTDSFTGADLKALLYNAQLE 1057



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 50/214 (23%), Positives = 97/214 (45%), Gaps = 18/214 (8%)

Query: 163 ILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSD---LMSKWLGESEKLVKNLFELARQH 219
           +LL G  G+GKS LAKA+  EA +     V   D   L  K L   +K ++  F  A   
Sbjct: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWM 654

Query: 220 KPSIIFIDEVDSLCG----SRNENESEAARRIKTEFLVQMQGVGNNNDGTLV-LGATN-- 272
           +PS++ +D++D + G      +E+  +A +  +    +        + G+LV L AT+  
Sbjct: 655 QPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQS 714

Query: 273 ----IPWVLDSAIRRRFEKRIYIPLPEEAARAQ----MFRLHLGSTPHNLTDANIHELAR 324
                P ++ +     F+   +I  P +  R +    + +  L    +  TD ++  +A+
Sbjct: 715 QQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAK 774

Query: 325 KTEGYSGADISIIVRDSLMQPVRKVQSATHFKKV 358
           +T G+   D +++V  ++   + +   +T  K V
Sbjct: 775 ETGGFVARDFTVLVDRAIHSRLSRQSISTREKLV 808


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  128 bits (322), Expect = 9e-30
 Identities = 82/235 (34%), Positives = 138/235 (58%), Gaps = 9/235 (3%)

Query: 120 EKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFGPPGTGKSYLAK 178
           +KP++ + D+ G++  K+ ++EAV LP+    L+      P RG+L++GPPG GK+ LAK
Sbjct: 154 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 213

Query: 179 AVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNE 238
           AVA     + F  V  S+ + K+LGE  ++V+++F LA+++ P+IIFIDE+D++   R +
Sbjct: 214 AVAHHTT-AAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD 272

Query: 239 NESEAAR---RIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPL 293
            ++ A R   RI  E L QM G  + N    V+ ATN    LD A+ R  R +++I  PL
Sbjct: 273 AQTGADREVQRILLELLNQMDGF-DQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPL 331

Query: 294 PEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRK 348
           P+   +  +F   + S  +   + ++ +   + +  SGADI+ I ++S M  VR+
Sbjct: 332 PDRRQKRLIFST-ITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRE 385


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  128 bits (322), Expect = 9e-30
 Identities = 82/235 (34%), Positives = 138/235 (58%), Gaps = 9/235 (3%)

Query: 120 EKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFGPPGTGKSYLAK 178
           +KP++ + D+ G++  K+ ++EAV LP+    L+      P RG+L++GPPG GK+ LAK
Sbjct: 127 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 186

Query: 179 AVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNE 238
           AVA     + F  V  S+ + K+LGE  ++V+++F LA+++ P+IIFIDE+D++   R +
Sbjct: 187 AVAHHTT-AAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD 245

Query: 239 NESEAAR---RIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPL 293
            ++ A R   RI  E L QM G  + N    V+ ATN    LD A+ R  R +++I  PL
Sbjct: 246 AQTGADREVQRILLELLNQMDGF-DQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPL 304

Query: 294 PEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRK 348
           P+   +  +F   + S  +   + ++ +   + +  SGADI+ I ++S M  VR+
Sbjct: 305 PDRRQKRLIFST-ITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRE 358


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  128 bits (322), Expect = 9e-30
 Identities = 82/235 (34%), Positives = 138/235 (58%), Gaps = 9/235 (3%)

Query: 120 EKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFGPPGTGKSYLAK 178
           +KP++ + D+ G++  K+ ++EAV LP+    L+      P RG+L++GPPG GK+ LAK
Sbjct: 158 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 217

Query: 179 AVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNE 238
           AVA     + F  V  S+ + K+LGE  ++V+++F LA+++ P+IIFIDE+D++   R +
Sbjct: 218 AVAHHTT-AAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD 276

Query: 239 NESEAAR---RIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPL 293
            ++ A R   RI  E L QM G  + N    V+ ATN    LD A+ R  R +++I  PL
Sbjct: 277 AQTGADREVQRILLELLNQMDGF-DQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPL 335

Query: 294 PEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRK 348
           P+   +  +F   + S  +   + ++ +   + +  SGADI+ I ++S M  VR+
Sbjct: 336 PDRRQKRLIFST-ITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRE 389


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score =  128 bits (322), Expect = 9e-30
 Identities = 83/232 (35%), Positives = 137/232 (59%), Gaps = 12/232 (5%)

Query: 119 MEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYL 176
           ++  N+ +  V G+E AK+ L+E V   +K P  FT  G + P +GILL GPPGTGK+ L
Sbjct: 331 VQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLP-KGILLVGPPGTGKTLL 388

Query: 177 AKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR 236
           A+AVA EA+   F+  S S+    ++G     ++NLF  A+ + P +IFIDE+DS+ G R
Sbjct: 389 ARAVAGEAD-VPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKR 447

Query: 237 NENESEA-ARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPL 293
            E+     +R+   + L +M G    N+G +++GATN P  LD+A+ R  RF+ ++ +P 
Sbjct: 448 IESPMHPYSRQTINQLLAEMDGF-KPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPR 506

Query: 294 PEEAARAQMFRLHLGSTPHNLT-DANIHELARKTEGYSGADISIIVRDSLMQ 344
           P+   R ++ + +L     + + D  I  +AR T G+SGA++  +V  + ++
Sbjct: 507 PDVKGRTEILKWYLNKIKFDQSVDPEI--IARGTVGFSGAELENLVNQAALK 556


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score =  128 bits (322), Expect = 9e-30
 Identities = 83/232 (35%), Positives = 137/232 (59%), Gaps = 12/232 (5%)

Query: 119 MEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYL 176
           ++  N+ +  V G+E AK+ L+E V   +K P  FT  G + P +GILL GPPGTGK+ L
Sbjct: 274 VQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLP-KGILLVGPPGTGKTLL 331

Query: 177 AKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR 236
           A+AVA EA+   F+  S S+    ++G     ++NLF  A+ + P +IFIDE+DS+ G R
Sbjct: 332 ARAVAGEAD-VPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKR 390

Query: 237 NENESEA-ARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPL 293
            E+     +R+   + L +M G    N+G +++GATN P  LD+A+ R  RF+ ++ +P 
Sbjct: 391 IESPMHPYSRQTINQLLAEMDGF-KPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPR 449

Query: 294 PEEAARAQMFRLHLGSTPHNLT-DANIHELARKTEGYSGADISIIVRDSLMQ 344
           P+   R ++ + +L     + + D  I  +AR T G+SGA++  +V  + ++
Sbjct: 450 PDVKGRTEILKWYLNKIKFDQSVDPEI--IARGTVGFSGAELENLVNQAALK 499


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,668,709
Number of Sequences: 37866
Number of extensions: 762596
Number of successful extensions: 2899
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 2508
Number of HSP's gapped (non-prelim): 343
length of query: 437
length of database: 18,247,518
effective HSP length: 105
effective length of query: 332
effective length of database: 14,271,588
effective search space: 4738167216
effective search space used: 4738167216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.