Guide to the Human Genome
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Search of human proteins with 126352700

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|126352700 elastin isoform b precursor [Homo sapiens]
         (677 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|126352700 elastin isoform b precursor [Homo sapiens]              1356   0.0  
gi|126352322 elastin isoform c precursor [Homo sapiens]              1342   0.0  
gi|126352608 elastin isoform e precursor [Homo sapiens]              1337   0.0  
gi|126352446 elastin isoform d precursor [Homo sapiens]              1330   0.0  
gi|126352440 elastin isoform a precursor [Homo sapiens]              1325   0.0  
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]     181   2e-45
gi|148536825 alpha 1 type IV collagen preproprotein [Homo sapiens]    170   5e-42
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]     169   6e-42
gi|15890086 type IV collagen alpha 5 isoform 2 precursor [Homo s...   160   4e-39
gi|4502955 type IV collagen alpha 5 isoform 1 precursor [Homo sa...   160   4e-39
gi|15890088 type IV collagen alpha 5 isoform 3 precursor [Homo s...   160   4e-39
gi|116256354 alpha 2 type IV collagen preproprotein [Homo sapiens]    160   4e-39
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom...   157   2e-38
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom...   157   2e-38
gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]      152   1e-36
gi|48762934 alpha 2 type I collagen [Homo sapiens]                    152   1e-36
gi|32964830 collagen, type VIII, alpha 2 [Homo sapiens]               150   3e-36
gi|32895368 alpha 1 type VIII collagen precursor [Homo sapiens]       149   1e-35
gi|17738302 alpha 1 type VIII collagen precursor [Homo sapiens]       149   1e-35
gi|148536823 type IV alpha 6 collagen isoform A precursor [Homo ...   147   2e-35
gi|16357503 type IV alpha 6 collagen isoform B precursor [Homo s...   147   2e-35
gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]               144   3e-34
gi|18105032 type X collagen alpha 1 precursor [Homo sapiens]          143   5e-34
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]         139   7e-33
gi|89142737 alpha 3 type IV collagen isoform 5 precursor [Homo s...   139   7e-33
gi|89142735 alpha 3 type IV collagen isoform 4 precursor [Homo s...   139   7e-33
gi|89142733 alpha 3 type IV collagen isoform 2 precursor [Homo s...   139   7e-33
gi|89142730 alpha 3 type IV collagen isoform 1 precursor [Homo s...   139   7e-33
gi|100913220 alpha 1 type XVI collagen precursor [Homo sapiens]       139   9e-33
gi|115392133 collagen, type XXIV, alpha 1 [Homo sapiens]              138   1e-32

>gi|126352700 elastin isoform b precursor [Homo sapiens]
          Length = 677

 Score = 1356 bits (3510), Expect = 0.0
 Identities = 677/677 (100%), Positives = 677/677 (100%)

Query: 1   MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGL 60
           MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGL
Sbjct: 1   MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGL 60

Query: 61  AGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVP 120
           AGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVP
Sbjct: 61  AGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVP 120

Query: 121 QPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIP 180
           QPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIP
Sbjct: 121 QPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIP 180

Query: 181 GVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV 240
           GVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV
Sbjct: 181 GVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV 240

Query: 241 GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAA 300
           GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAA
Sbjct: 241 GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAA 300

Query: 301 AKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIPGAAVPGVVSP 360
           AKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIPGAAVPGVVSP
Sbjct: 301 AKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIPGAAVPGVVSP 360

Query: 361 EAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVG 420
           EAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVG
Sbjct: 361 EAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVG 420

Query: 421 GVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGV 480
           GVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGV
Sbjct: 421 GVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGV 480

Query: 481 APGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVP 540
           APGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVP
Sbjct: 481 APGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVP 540

Query: 541 GLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAA 600
           GLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAA
Sbjct: 541 GLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAA 600

Query: 601 AKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSP 660
           AKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSP
Sbjct: 601 AKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSP 660

Query: 661 IFPGGACLGKACGRKRK 677
           IFPGGACLGKACGRKRK
Sbjct: 661 IFPGGACLGKACGRKRK 677


>gi|126352322 elastin isoform c precursor [Homo sapiens]
          Length = 692

 Score = 1342 bits (3473), Expect = 0.0
 Identities = 677/692 (97%), Positives = 677/692 (97%), Gaps = 15/692 (2%)

Query: 1   MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYP----------ALGPGG 50
           MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYP          ALGPGG
Sbjct: 1   MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPGAGLGALGGGALGPGG 60

Query: 51  KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG 110
           KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG
Sbjct: 61  KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG 120

Query: 111 LGVSA-----GAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGV 165
           LGVSA     GAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGV
Sbjct: 121 LGVSAAPSVPGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGV 180

Query: 166 KPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGV 225
           KPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGV
Sbjct: 181 KPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGV 240

Query: 226 AGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGI 285
           AGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGI
Sbjct: 241 AGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGI 300

Query: 286 AGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVP 345
           AGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVP
Sbjct: 301 AGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVP 360

Query: 346 GAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIP 405
           GAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIP
Sbjct: 361 GAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIP 420

Query: 406 GVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPG 465
           GVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPG
Sbjct: 421 GVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPG 480

Query: 466 VGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLG 525
           VGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLG
Sbjct: 481 VGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLG 540

Query: 526 VGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGI 585
           VGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGI
Sbjct: 541 VGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGI 600

Query: 586 PGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKA 645
           PGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKA
Sbjct: 601 PGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKA 660

Query: 646 AKYGVAARPGFGLSPIFPGGACLGKACGRKRK 677
           AKYGVAARPGFGLSPIFPGGACLGKACGRKRK
Sbjct: 661 AKYGVAARPGFGLSPIFPGGACLGKACGRKRK 692


>gi|126352608 elastin isoform e precursor [Homo sapiens]
          Length = 705

 Score = 1337 bits (3460), Expect = 0.0
 Identities = 677/705 (96%), Positives = 677/705 (96%), Gaps = 28/705 (3%)

Query: 1   MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYP----------ALGPGG 50
           MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYP          ALGPGG
Sbjct: 1   MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPGAGLGALGGGALGPGG 60

Query: 51  KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG 110
           KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG
Sbjct: 61  KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG 120

Query: 111 LGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAP 170
           LGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAP
Sbjct: 121 LGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAP 180

Query: 171 GVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAG 230
           GVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAG
Sbjct: 181 GVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAG 240

Query: 231 KAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGT 290
           KAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGT
Sbjct: 241 KAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGT 300

Query: 291 PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIP 350
           PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIP
Sbjct: 301 PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIP 360

Query: 351 GAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGV 410
           GAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGV
Sbjct: 361 GAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGV 420

Query: 411 PGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAP 470
           PGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAP
Sbjct: 421 PGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAP 480

Query: 471 GVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGV 530
           GVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGV
Sbjct: 481 GVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGV 540

Query: 531 PGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVV 590
           PGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVV
Sbjct: 541 PGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVV 600

Query: 591 GAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKY-- 648
           GAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKY  
Sbjct: 601 GAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGA 660

Query: 649 ----------------GVAARPGFGLSPIFPGGACLGKACGRKRK 677
                           GVAARPGFGLSPIFPGGACLGKACGRKRK
Sbjct: 661 AGLGGVLGGAGQFPLGGVAARPGFGLSPIFPGGACLGKACGRKRK 705


>gi|126352446 elastin isoform d precursor [Homo sapiens]
          Length = 711

 Score = 1330 bits (3443), Expect = 0.0
 Identities = 677/711 (95%), Positives = 677/711 (95%), Gaps = 34/711 (4%)

Query: 1   MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYP----------ALGPGG 50
           MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYP          ALGPGG
Sbjct: 1   MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPGAGLGALGGGALGPGG 60

Query: 51  KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG 110
           KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG
Sbjct: 61  KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG 120

Query: 111 LGVSA-----GAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGV 165
           LGVSA     GAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGV
Sbjct: 121 LGVSAAPSVPGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGV 180

Query: 166 KPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGV 225
           KPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGV
Sbjct: 181 KPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGV 240

Query: 226 AGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGI 285
           AGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGI
Sbjct: 241 AGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGI 300

Query: 286 AGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVP 345
           AGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVP
Sbjct: 301 AGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVP 360

Query: 346 GAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIP 405
           GAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIP
Sbjct: 361 GAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIP 420

Query: 406 GVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKY-------------------GLVP 446
           GVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKY                   GLVP
Sbjct: 421 GVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGVGTPAAAAAKAAAKAAQFGLVP 480

Query: 447 GVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVA 506
           GVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVA
Sbjct: 481 GVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVA 540

Query: 507 AKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKY 566
           AKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKY
Sbjct: 541 AKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKY 600

Query: 567 GAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGL 626
           GAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGL
Sbjct: 601 GAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGL 660

Query: 627 GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGACLGKACGRKRK 677
           GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGACLGKACGRKRK
Sbjct: 661 GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGACLGKACGRKRK 711


>gi|126352440 elastin isoform a precursor [Homo sapiens]
          Length = 724

 Score = 1325 bits (3430), Expect = 0.0
 Identities = 677/724 (93%), Positives = 677/724 (93%), Gaps = 47/724 (6%)

Query: 1   MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYP----------ALGPGG 50
           MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYP          ALGPGG
Sbjct: 1   MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPGAGLGALGGGALGPGG 60

Query: 51  KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG 110
           KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG
Sbjct: 61  KPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG 120

Query: 111 LGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAP 170
           LGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAP
Sbjct: 121 LGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAP 180

Query: 171 GVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAG 230
           GVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAG
Sbjct: 181 GVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAG 240

Query: 231 KAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGT 290
           KAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGT
Sbjct: 241 KAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGT 300

Query: 291 PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIP 350
           PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIP
Sbjct: 301 PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIP 360

Query: 351 GAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGV 410
           GAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGV
Sbjct: 361 GAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGV 420

Query: 411 PGVGGVPGVGGVPGVGISPEAQAAAAAKAAKY-------------------GLVPGVGVA 451
           PGVGGVPGVGGVPGVGISPEAQAAAAAKAAKY                   GLVPGVGVA
Sbjct: 421 PGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGVGTPAAAAAKAAAKAAQFGLVPGVGVA 480

Query: 452 PGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQL 511
           PGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQL
Sbjct: 481 PGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQL 540

Query: 512 RAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVP 571
           RAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVP
Sbjct: 541 RAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVP 600

Query: 572 GVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGV 631
           GVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGV
Sbjct: 601 GVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGV 660

Query: 632 GGLGGIPPAAAAKAAKY------------------GVAARPGFGLSPIFPGGACLGKACG 673
           GGLGGIPPAAAAKAAKY                  GVAARPGFGLSPIFPGGACLGKACG
Sbjct: 661 GGLGGIPPAAAAKAAKYGAAGLGGVLGGAGQFPLGGVAARPGFGLSPIFPGGACLGKACG 720

Query: 674 RKRK 677
           RKRK
Sbjct: 721 RKRK 724


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score =  181 bits (459), Expect = 2e-45
 Identities = 238/715 (33%), Positives = 266/715 (37%), Gaps = 95/715 (13%)

Query: 23  PSRPGGVPGAIPG--GVPGGVFYPAL-GPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPG 79
           P+ P G PG+ PG  G PG +    L G  G+P  P P G  G     G    P  T P 
Sbjct: 282 PAGPKGEPGS-PGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPA 340

Query: 80  AL--VPGGV-ADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVP--QPGAGVKPGKVPGV 134
                PG V A   A  +  +   G  GV G  G    AGA  P   PGA  +PG     
Sbjct: 341 GPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGAN 400

Query: 135 GLPGVYPGGVLPGARFP----GVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQP 190
           G PG+      PGAR P    G G  PG P G   +P APG  G        GP G   P
Sbjct: 401 GAPGIAGAPGFPGARGPSGPQGPGGPPG-PKGNSGEPGAPGSKGDTGAKGEPGPVGVQGP 459

Query: 191 GVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV----GPQAAA 246
             P G   K     G  G P  TG LP   GP G  G  G  G+P   GV    GP    
Sbjct: 460 PGPAGEEGKR----GARGEPGPTG-LP---GPPGERGGPGSRGFPGADGVAGPKGPAGER 511

Query: 247 AAAAKAAAKFGAGAAGV-----LPGVGG-AGVPGVPG--------------------AIP 280
            +   A  K   G AG      LPG  G  G PG PG                      P
Sbjct: 512 GSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPP 571

Query: 281 GIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPG-FGP-GVVGVPGA-GVPGVGV 336
           G  G AGV G P    AA    KA + G     VPG PG  GP G  G  GA G PG   
Sbjct: 572 GARGQAGVMGFPGPKGAAGEPGKAGERG-----VPGPPGAVGPAGKDGEAGAQGPPGPAG 626

Query: 337 PGAGIPVVPGAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPG 396
           P         AG PG    G+  P      A K  + G    +G  G P+   G  GFPG
Sbjct: 627 PAGERGEQGPAGSPG--FQGLPGPAGPPGEAGKPGEQGVPGDLGAPG-PSGARGERGFPG 683

Query: 397 FGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGL--------VPGV 448
              GV G PG AG  G  G PG  G  G   +P A  +  A   + G+        +PG 
Sbjct: 684 ER-GVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQ-GMPGERGAAGLPGP 741

Query: 449 GVAPGVGVAPGVGVAPGV----GLAPGVGVAPGVGVAPG----VGVAPGIGPGGVAAAAK 500
               G     G   +PG     GL   +G  PG   APG     G +   GP G   A  
Sbjct: 742 KGDRGDAGPKGADGSPGKDGVRGLTGPIG-PPGPAGAPGDKGESGPSGPAGPTGARGAPG 800

Query: 501 SAAKVAAKAQLRAAAGLGA-GIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALA 559
              +         A   GA G PG     G  G    AG PG    AG PG     GA  
Sbjct: 801 DRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGA-P 859

Query: 560 AAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGL- 618
            AK A+  A  PG  G  GA G VG PG    AGP      A         G  G AG  
Sbjct: 860 GAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRP 919

Query: 619 GGLG-------VGGLGVPGVGGLGGIP--PAAAAKAAKYGVAARPGFGLSPIFPG 664
           G +G        G  G PG  G  G P  P     A + GV   PG      FPG
Sbjct: 920 GEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPG 974



 Score =  169 bits (427), Expect = 1e-41
 Identities = 224/649 (34%), Positives = 254/649 (39%), Gaps = 64/649 (9%)

Query: 23  PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAG-----AGLGAGLGAFPAVTF 77
           P  P G PG    G+PG    P  GP G P  P P GL G        G    +   ++ 
Sbjct: 122 PRGPAGPPGR--DGIPGQPGLP--GPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISV 177

Query: 78  PGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQ--PGAGVKPGKVPGVG 135
           PG + P G          A    G  G PG  G   ++G + P+  PG   K G     G
Sbjct: 178 PGPMGPSGPRGLPGP-PGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAG 236

Query: 136 LPGVYPGGVLP----GAR-FPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQP 190
            PG  PG   P    GAR  PG   LPG+    G      G+ GA       GP G  +P
Sbjct: 237 KPG-RPGERGPPGPQGARGLPGTAGLPGMKGHRGFS----GLDGAKGDAGPAGPKG--EP 289

Query: 191 GVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVA---GAAGKAGYPTGTGVGPQAAAA 247
           G P      AP   G  GLP   G+ P   GP G     GA G AG P  T  GP     
Sbjct: 290 GSP--GENGAPGQMGPRGLPGERGR-PGAPGPAGARGNDGATGAAGPPGPT--GPAGPPG 344

Query: 248 AAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYG 307
                 AK  AG  G     G  GV G PG  PG  G AG   PA    A     A    
Sbjct: 345 FPGAVGAKGEAGPQGPRGSEGPQGVRGEPGP-PGPAGAAG---PAGNPGADGQPGAKGAN 400

Query: 308 AAAGLVPGGPGFGPGVVGVPGAGVPGVGVPG----AGIPVVPGA-GIPGA-AVPGVVSPE 361
            A G + G PGF PG  G  G   PG G PG    +G P  PG+ G  GA   PG V  +
Sbjct: 401 GAPG-IAGAPGF-PGARGPSGPQGPG-GPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQ 457

Query: 362 AAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGG 421
                A +  K GAR   G  G+P    G  G  G G G  G PG  GV G  G  G  G
Sbjct: 458 GPPGPAGEEGKRGARGEPGPTGLP----GPPGERG-GPGSRGFPGADGVAGPKGPAGERG 512

Query: 422 VPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVA 481
            PG    P+     A +  + GL PG     G   +PG     G     G    PG    
Sbjct: 513 SPGPA-GPKGSPGEAGRPGEAGL-PGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGP 570

Query: 482 PGV-GVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLG-AGIPGLGVGVGVPGLGVGAGV 539
           PG  G A  +G  G   AA    K   +        +G AG  G     G PG    AG 
Sbjct: 571 PGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE 630

Query: 540 PGLGVGAGVPGFGAVPG-ALAAAKAAKYG-AAVPGVLGG---LGALGGVGIPG--GVVG- 591
            G    AG PGF  +PG A    +A K G   VPG LG     GA G  G PG  GV G 
Sbjct: 631 RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGP 690

Query: 592 AGPAAAAAAAKAAAKAAQFGLVGAAGL-GGLGVGGL-GVPGVGGLGGIP 638
            GPA    A  A       G  GA G  G  G  GL G+PG  G  G+P
Sbjct: 691 PGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLP 739



 Score =  152 bits (384), Expect = 1e-36
 Identities = 221/732 (30%), Positives = 257/732 (35%), Gaps = 117/732 (15%)

Query: 3    GLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPG-GVPGGVFYPALGPGGKPLKPVPGGLA 61
            G T A   PG +     +  P  P G  G     G PG    P  GP G+   P   G  
Sbjct: 443  GDTGAKGEPGPV----GVQGPPGPAGEEGKRGARGEPGPTGLP--GPPGERGGPGSRGFP 496

Query: 62   GA-GLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVP 120
            GA G+    G       PG   P G    A          G  G+PG  GL  S G+  P
Sbjct: 497  GADGVAGPKGPAGERGSPGPAGPKGSPGEAGR-------PGEAGLPGAKGLTGSPGSPGP 549

Query: 121  QPGAGVKPGKVPGVGLPGVYPGGVLPGAR-------FPGVGVLPGVPTGAGVK--PKAPG 171
                G  PG     G PG  PG   PGAR       FPG     G P  AG +  P  PG
Sbjct: 550  DGKTG-PPGPAGQDGRPGP-PGP--PGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPG 605

Query: 172  VGGAFAGIPGVGPFGGPQPGVPLGY-----PIKAPK---LPGGYGLPYTTGK-----LPY 218
              G        G  G P P  P G      P  +P    LPG  G P   GK     +P 
Sbjct: 606  AVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPG 665

Query: 219  GYGPGGVAGAAGKAGYPTGTGV-------GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAG 271
              G  G +GA G+ G+P   GV       GP+ A  A     AK  AGA G     G  G
Sbjct: 666  DLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPG 725

Query: 272  VPGVPG-----AIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGV 326
            + G+PG      +PG  G  G   P  A  +    K    G    + P GP   PG  G 
Sbjct: 726  LQGMPGERGAAGLPGPKGDRGDAGPKGADGSPG--KDGVRGLTGPIGPPGPAGAPGDKGE 783

Query: 327  PGA----------GVPG----VGVPG-AGIPVVPGA-------GIPG-------AAVPGV 357
             G           G PG     G PG AG    PGA       G PG       A  PG 
Sbjct: 784  SGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGP 843

Query: 358  VSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVP 417
              P             GA+   G  G P    GA GFPG   G  G PG +G  G  G P
Sbjct: 844  AGPAGPPGPIGNVGAPGAKGARGSAGPP----GATGFPG-AAGRVGPPGPSGNAGPPGPP 898

Query: 418  GVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPG 477
            G  G  G G  P  +   A +  + G  PG     G   +PG   A G   APG     G
Sbjct: 899  GPAGKEG-GKGPRGETGPAGRPGEVG-PPGPPGPAGEKGSPG---ADGPAGAPGTPGPQG 953

Query: 478  VGVAPGVGVAPGI-GPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVG 536
            +    GV   PG  G  G       + +   +    A+   G   P     +G PGL   
Sbjct: 954  IAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGP-----MGPPGL--- 1005

Query: 537  AGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAA 596
            AG PG     G PG    PG    +  AK      G  G  GA G  G PG V  AG + 
Sbjct: 1006 AGPPGESGREGAPGAEGSPGR-DGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSG 1064

Query: 597  AAAAAKAAAKAAQFGLVGAAGLGGL-----------GVGGLGVPGVGGLGGI--PPAAAA 643
                   A  A   G VGA G  G              G  G+ G  G  G+  PP    
Sbjct: 1065 DRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPG 1124

Query: 644  KAAKYGVAARPG 655
               + G +   G
Sbjct: 1125 SPGEQGPSGASG 1136



 Score =  150 bits (378), Expect = 5e-36
 Identities = 214/682 (31%), Positives = 243/682 (35%), Gaps = 107/682 (15%)

Query: 25   RPG--GVPGA-----IPGGV-PGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFP--- 73
            RPG  G+PGA      PG   P G   P  GP G+  +P P G  GA   AG+  FP   
Sbjct: 528  RPGEAGLPGAKGLTGSPGSPGPDGKTGPP-GPAGQDGRPGPPGPPGARGQAGVMGFPGPK 586

Query: 74   -AVTFPGAL----VPGGVADAAAAYKAAKAGA----------------GLGGVPGVGGLG 112
             A   PG      VPG       A K  +AGA                G  G PG  GL 
Sbjct: 587  GAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLP 646

Query: 113  VSAGAVVPQPGAGVKPGK--VPG-VGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPK- 168
              AG     PG   KPG+  VPG +G PG  P G      FPG   + G P  AG +   
Sbjct: 647  GPAGP----PGEAGKPGEQGVPGDLGAPG--PSGARGERGFPGERGVQGPPGPAGPRGAN 700

Query: 169  -APGVGGAF--AGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGV 225
             APG  GA   AG PG  P     PG+        P   G  GLP   G      GP G 
Sbjct: 701  GAPGNDGAKGDAGAPGA-PGSQGAPGLQ-----GMPGERGAAGLPGPKGDRGDA-GPKGA 753

Query: 226  AGAAGKAGYPTGTG-VGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGG 284
             G+ GK G    TG +GP   A A         +G AG     G  G  G PG  PG  G
Sbjct: 754  DGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGP-PGPAG 812

Query: 285  IAGV----GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA-------GVPG 333
             AG     G P A      A      G      P GP    G VG PGA       G PG
Sbjct: 813  FAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPG 872

Query: 334  V-GVPGAGIPVVPGAGIPGAAVPGVVSPEAAAKAAAKAAKYG--ARPG-VGVGGIPTYG- 388
              G PGA   V P      A  PG   P           + G   RPG VG  G P    
Sbjct: 873  ATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAG 932

Query: 389  ----------VGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAK 438
                       GA G PG   G+ G  GV G+PG  G  G  G+PG    P  Q  + A 
Sbjct: 933  EKGSPGADGPAGAPGTPG-PQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGAS 991

Query: 439  AAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGV----GVAPGIGPGG 494
              +    PG    PG+   PG     G   APG   +PG   +PG     G     GP G
Sbjct: 992  GERGP--PGPMGPPGLAGPPGESGREG---APGAEGSPGRDGSPGAKGDRGETGPAGPPG 1046

Query: 495  VAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAV 554
               A  +   V    +       G   P   VG                VGA  P     
Sbjct: 1047 APGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGP---------------VGARGPAGPQG 1091

Query: 555  PGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVG 614
            P         +    + G  G  G  G  G PG     GP+ A+  A         G  G
Sbjct: 1092 PRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGAPG 1151

Query: 615  AAGLGGLGVGGLGVPGVGGLGG 636
              GL GL  G +G PG  G  G
Sbjct: 1152 KDGLNGL-PGPIGPPGPRGRTG 1172



 Score =  144 bits (362), Expect = 3e-34
 Identities = 198/620 (31%), Positives = 216/620 (34%), Gaps = 91/620 (14%)

Query: 23   PSRPGGVPGAI-PGGVPG--GVFYPALGPGGKPLKP----VPGGLAGAGLGAGLG--AFP 73
            P+ P G  G   P G PG  G+  PA GP G+  KP    VPG L   G     G   FP
Sbjct: 624  PAGPAGERGEQGPAGSPGFQGLPGPA-GPPGEAGKPGEQGVPGDLGAPGPSGARGERGFP 682

Query: 74   AVTF----PGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPG 129
                    PG   P G A+ A     AK  AG  G PG      S GA    PG    PG
Sbjct: 683  GERGVQGPPGPAGPRG-ANGAPGNDGAKGDAGAPGAPG------SQGA----PGLQGMPG 731

Query: 130  KVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQ 189
            +    GLPG  P G    A           P GA   P   GV G    I   GP G P 
Sbjct: 732  ERGAAGLPG--PKGDRGDAG----------PKGADGSPGKDGVRGLTGPIGPPGPAGAPG 779

Query: 190  ------PGVPLGYPIKAPKLPGGYGLPYTTGKLPYGY-GPGGVAGAAGKAGYPTGTGV-- 240
                  P  P G P  A   PG  G P   G  P G+ GP G  G  G  G P   G   
Sbjct: 780  DKGESGPSGPAG-PTGARGAPGDRGEPGPPG--PAGFAGPPGADGQPGAKGEPGDAGAKG 836

Query: 241  --GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAA-AAAA 297
              GP   A  A         GA G     G AG PG  G  PG  G  G   P+  A   
Sbjct: 837  DAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATG-FPGAAGRVGPPGPSGNAGPP 895

Query: 298  AAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIPGAAVPGV 357
                 A K G        GP   PG VG PG   P      AG    PGA  P A  PG 
Sbjct: 896  GPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGP------AGEKGSPGADGP-AGAPGT 948

Query: 358  VSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPG-----FGVGVGGIPGVAGVPG 412
              P+  A         G R   G  G+P    G  G PG        G  G PG  G PG
Sbjct: 949  PGPQGIAGQRGVVGLPGQRGERGFPGLP----GPSGEPGKQGPSGASGERGPPGPMGPPG 1004

Query: 413  VGGVPGVG---GVPGVGISPEAQAAAAAKAAKYGLVP-GVGVAPGVGVAPG-VGVAPGVG 467
            + G PG     G PG   SP    +  AK  +    P G   APG   APG VG A   G
Sbjct: 1005 LAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSG 1064

Query: 468  LAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKA--QLRAAAGLGA-----G 520
                 G A   G    VG     GP G         +   +     R  +GL       G
Sbjct: 1065 DRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPG 1124

Query: 521  IPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGAL 580
             PG     G  G     G PG     G  G   +PG +            PG  G  G  
Sbjct: 1125 SPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPIGP----------PGPRGRTGDA 1174

Query: 581  GGVGIPGGVVGAGPAAAAAA 600
            G VG PG     GP    +A
Sbjct: 1175 GPVGPPGPPGPPGPPGPPSA 1194



 Score =  139 bits (349), Expect = 1e-32
 Identities = 183/561 (32%), Positives = 200/561 (35%), Gaps = 53/561 (9%)

Query: 101 GLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVP 160
           G  G PG  GLG   G   PQ   G       G+ +PG  P G       PG    PG P
Sbjct: 145 GPPGPPGPPGLG---GNFAPQLSYGYDEKSTGGISVPG--PMGPSGPRGLPGPPGAPG-P 198

Query: 161 TGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGY 220
            G    P  PG  GA   +   GP G P      G   K P  PG  G P          
Sbjct: 199 QGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGK-PGRPGERGPP---------- 247

Query: 221 GPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIP 280
           GP G  G  G AG P     G +     +    AK  AG AG     G  G  G PG + 
Sbjct: 248 GPQGARGLPGTAGLP-----GMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQM- 301

Query: 281 GIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGA 339
           G  G+ G  G P A   A A       GAA    P GP    G  G PGA    VG  G 
Sbjct: 302 GPRGLPGERGRPGAPGPAGARGNDGATGAAG---PPGPTGPAGPPGFPGA----VGAKGE 354

Query: 340 GIPVVPGAGIPGAAVPGVVSPEAAAKAAAKAAKYGA--RPGV-GVGGIPTYGVGAGGFPG 396
             P  P        V G   P   A AA  A   GA  +PG  G  G P    GA GFPG
Sbjct: 355 AGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGI-AGAPGFPG 413

Query: 397 FGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGL--VPGVGVAPGV 454
              G  G  G  G PG  G  G  G PG     +    A  +    G+   PG     G 
Sbjct: 414 -ARGPSGPQGPGGPPGPKGNSGEPGAPG----SKGDTGAKGEPGPVGVQGPPGPAGEEGK 468

Query: 455 GVAPGVGVAPGVGLAPGVGVAPGVGVAPGV-GVAPGIGPGGVAAAAKSAAKVAAKAQLRA 513
             A G     G+   PG    PG    PG  GVA   GP G A    S      K     
Sbjct: 469 RGARGEPGPTGLPGPPGERGGPGSRGFPGADGVA---GPKGPAGERGSPGPAGPKGSPGE 525

Query: 514 AAGLG-AGIP---GLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAA 569
           A   G AG+P   GL    G PG     G PG     G PG    PGA   A    +   
Sbjct: 526 AGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGF-PG 584

Query: 570 VPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVP 629
             G  G  G  G  G+PG     GPA     A A       G  G  G  G   G  G  
Sbjct: 585 PKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQG-PAGSPGFQ 643

Query: 630 GVGGLGGIPPAAAAKAAKYGV 650
           G+ G  G PP  A K  + GV
Sbjct: 644 GLPGPAG-PPGEAGKPGEQGV 663



 Score =  111 bits (277), Expect = 2e-24
 Identities = 159/499 (31%), Positives = 178/499 (35%), Gaps = 111/499 (22%)

Query: 221 GPGGVAGAAGKAGYPTGTGV-------GPQAAAAAAAKAAAKF----------GAGAAGV 263
           GP G AG  G+ G P   G+       GP          A +           G    G 
Sbjct: 121 GPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP 180

Query: 264 LPGVGGAGVPGVPGAIPGIGGIAG-VGTPAAAAAAAAAAKAAKYG--------AAAGLVP 314
           +   G  G+PG PGA PG  G  G  G P    A+         G          AG  P
Sbjct: 181 MGPSGPRGLPGPPGA-PGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAG-KP 238

Query: 315 GGPG-FGP----GVVGVPG-AGVPGV-------GVPGA----------GIPVVPGA-GIP 350
           G PG  GP    G  G+PG AG+PG+       G+ GA          G P  PG  G P
Sbjct: 239 GRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAP 298

Query: 351 G----AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPG 406
           G      +PG      A   A      GA    G  G PT   G  GFPG  VG  G  G
Sbjct: 299 GQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPG-PTGPAGPPGFPG-AVGAKGEAG 356

Query: 407 VAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGV 466
             G  G  G  GV G PG    P   A AA  A      PG    PG   A G   APG+
Sbjct: 357 PQGPRGSEGPQGVRGEPG----PPGPAGAAGPAGN----PGADGQPG---AKGANGAPGI 405

Query: 467 GLAPGVGVAPGVGVAPGVGVAPG-IGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLG 525
             APG   A G     G G  PG  G  G   A  S     AK           G PG  
Sbjct: 406 AGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAK-----------GEPG-- 452

Query: 526 VGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALG---- 581
             VGV G    AG  G     G PG   +PG              PG  GG G+ G    
Sbjct: 453 -PVGVQGPPGPAGEEGKRGARGEPGPTGLPGP-------------PGERGGPGSRGFPGA 498

Query: 582 -GVGIPGGVVG----AGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGG 636
            GV  P G  G     GPA    +   A +  + GL GA GL     G  G PG  G  G
Sbjct: 499 DGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL----TGSPGSPGPDGKTG 554

Query: 637 IPPAAAAKAAKYGVAARPG 655
            PP  A +  + G    PG
Sbjct: 555 -PPGPAGQDGRPGPPGPPG 572



 Score =  102 bits (253), Expect = 2e-21
 Identities = 148/442 (33%), Positives = 162/442 (36%), Gaps = 55/442 (12%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYP-----ALGPGGKPLKPVPGGLAG--------------A 63
            P  P G PG      P G   P     A G  G+P  P P G AG               
Sbjct: 771  PPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPG 830

Query: 64   GLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQ-P 122
              GA   A P      A  PG + +  A    AK   G  G PG  G   +AG V P  P
Sbjct: 831  DAGAKGDAGPPGPAGPAGPPGPIGNVGAP--GAKGARGSAGPPGATGFPGAAGRVGPPGP 888

Query: 123  GAGVKPGKVPGVGLP--GVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIP 180
                 P   PG      G  P G    A  PG    PG P  AG K  +PG  G  AG P
Sbjct: 889  SGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKG-SPGADGP-AGAP 946

Query: 181  GV-GPFG-GPQPGVPLGYPIKA-----PKLPGGYGLPYTTGKLPYGY----GPGGVAGAA 229
            G  GP G   Q GV +G P +      P LPG  G P   G  P G     GP G  G  
Sbjct: 947  GTPGPQGIAGQRGV-VGLPGQRGERGFPGLPGPSGEPGKQG--PSGASGERGPPGPMGPP 1003

Query: 230  GKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGA--IPGIGGIAG 287
            G AG P  +G   + A  A          GA G     G AG PG PGA   PG  G AG
Sbjct: 1004 GLAGPPGESG--REGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAG 1061

Query: 288  V-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG-AGVPGV-GVPGAGIPVV 344
              G       A  A      GA     P GP    G  G  G  G+ G  G  G   P  
Sbjct: 1062 KSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPG 1121

Query: 345  PGAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGI 404
            P  G PG   P   S  A  +    +A  GA    G+ G+P    G  G PG   G  G 
Sbjct: 1122 P-PGSPGEQGPSGASGPAGPRGPPGSA--GAPGKDGLNGLP----GPIGPPG-PRGRTGD 1173

Query: 405  PGVAGVPGVGGVPGVGGVPGVG 426
             G  G PG  G PG  G P  G
Sbjct: 1174 AGPVGPPGPPGPPGPPGPPSAG 1195



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 118/371 (31%), Positives = 135/371 (36%), Gaps = 49/371 (13%)

Query: 23   PSRPGGVPGAI-----PG--------GVPGGVFYPAL-------GPGGKPLKPVPGGLAG 62
            P+ P G PG I     PG        G PG   +P         GP G    P P G AG
Sbjct: 843  PAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAG 902

Query: 63   AGLGAG-LGAFPAVTFPGALVPGGVADAAA--AYKAAKAGAGLGGVPGVGGLGVSAGAVV 119
               G G  G       PG + P G    A       A   AG  G PG  G+    G VV
Sbjct: 903  KEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRG-VV 961

Query: 120  PQPGAGVKPGKVPGVGLPGVYPGGVLPGARF-----PGVGVLPGV--PTGAGVKPKAPGV 172
              PG   + G  PG+  P   PG   P         PG    PG+  P G   +  APG 
Sbjct: 962  GLPGQRGERG-FPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGA 1020

Query: 173  GGAFA--GIPGV-GPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAA 229
             G+    G PG  G  G   P  P G P  AP  PG  G    +G      G  G AG A
Sbjct: 1021 EGSPGRDGSPGAKGDRGETGPAGPPGAP-GAPGAPGPVGPAGKSGDR----GETGPAGPA 1075

Query: 230  GKAGYPTGTG-VGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGV 288
            G  G     G  GPQ       +   +   G  G     G  G PG PG+ PG  G +G 
Sbjct: 1076 GPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGS-PGEQGPSGA 1134

Query: 289  GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPG----AGIPVV 344
              PA       +A A       GL   GP   PG  G  G   P VG PG     G P  
Sbjct: 1135 SGPAGPRGPPGSAGAPGKDGLNGL--PGPIGPPGPRGRTGDAGP-VGPPGPPGPPGPPGP 1191

Query: 345  PGAGIPGAAVP 355
            P AG   + +P
Sbjct: 1192 PSAGFDFSFLP 1202



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 105/341 (30%), Positives = 127/341 (37%), Gaps = 30/341 (8%)

Query: 345 PGAGIP-GAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGG 403
           PGA +P G   P  V P+ +     +       P    G  P    G  G PG      G
Sbjct: 82  PGAEVPEGECCP--VCPDGSESPTDQETTGVEGPKGDTG--PRGPRGPAGPPGRD----G 133

Query: 404 IPGVAGVPGVGGVPGVGGVPGVG--ISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVG 461
           IPG  G+PG  G PG  G PG+G   +P+       K+     VPG     G    PG  
Sbjct: 134 IPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPP 193

Query: 462 VAPGVGLAPGVGVAPGVGVAPG-VGVAPGIGPGGVAAAAKSAAKVAAKAQL-----RAAA 515
            APG     G    PG   A G +G     GP G       A K     +      + A 
Sbjct: 194 GAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGAR 253

Query: 516 GL--GAGIPGLGVGVGVPGLGVG---AGVPGLGVGAGVPGFGAVPGALA----AAKAAKY 566
           GL   AG+PG+    G  GL      AG  G     G PG    PG +       +  + 
Sbjct: 254 GLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRP 313

Query: 567 GAAVP-GVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGG 625
           GA  P G  G  GA G  G PG    AGP     A  A  +A   G  G+ G  G+  G 
Sbjct: 314 GAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVR-GE 372

Query: 626 LGVPGVGGLGGIP--PAAAAKAAKYGVAARPGFGLSPIFPG 664
            G PG  G  G    P A  +    G    PG   +P FPG
Sbjct: 373 PGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPG 413


>gi|148536825 alpha 1 type IV collagen preproprotein [Homo sapiens]
          Length = 1669

 Score =  170 bits (430), Expect = 5e-42
 Identities = 207/683 (30%), Positives = 261/683 (38%), Gaps = 103/683 (15%)

Query: 26   PGGVPGAIPGG---------VPGGVFYPAL-GPGGKPLK--PVPGGLAGAGLGAGLGAFP 73
            P G PG  P G          PGG   P L GP G+P K  P+PG     GL    G FP
Sbjct: 602  PPGPPGYGPAGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPG-FP 660

Query: 74   AVT----FPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPG 129
                   FPG   PG            + G G  G PG  G+    G + P PG   +PG
Sbjct: 661  GPQGDRGFPGT--PGRPGLPGEKGAVGQPGIGFPGPPGPKGVDGLPGDMGP-PGTPGRPG 717

Query: 130  KVPGVGLPGVY-----PGGVLPGARFPGVGVLPGVPTGAGVK-----PKAPGVGGAFA-- 177
                 G PGV      PG  LPG +  G+  LPG+P   G K     P  PG  GA    
Sbjct: 718  FNGLPGNPGVQGQKGEPGVGLPGLK--GLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPP 775

Query: 178  GIPGV----GPFGGP----QPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAA 229
            G+ G+    GP G P     PGVP   P  A   PGG G P  +G       P G+ G  
Sbjct: 776  GLQGIRGEPGPPGLPGSVGSPGVPGIGPPGARGPPGGQGPPGLSG-------PPGIKGEK 828

Query: 230  GKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGA-GVPGVPGAIPGIGGIAGV 288
            G  G+P     GP+    A         +G  G LPG  GA G+PG PG+   +G +   
Sbjct: 829  GFPGFPGLDMPGPKGDKGAQGLPGITGQSGLPG-LPGQQGAPGIPGFPGSKGEMGVMGTP 887

Query: 289  GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAG 348
            G P +     A     + G        GP   PG+ G  G     VG+PG          
Sbjct: 888  GQPGSPGPVGAPGLPGEKGDHGFPGSSGPRGDPGLKGDKG----DVGLPGK--------- 934

Query: 349  IPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVA 408
                  PG +          +    G +  +G    P    G+ G P    G  G+PG  
Sbjct: 935  ------PGSMDKVDMGSMKGQKGDQGEKGQIG----PIGEKGSRGDP----GTPGVPGKD 980

Query: 409  GVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGL-VPGVGVAPGVGVAPGVGVAPGVG 467
            G  G  G PG  G PG+  +P A      K +  G+ +PG     GV   PG   +PG+ 
Sbjct: 981  GQAGQPGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLP 1040

Query: 468  LAPGVGVAPGVGVAPGVGVAPGI----GPGGVAAAAKSAAKVAAKAQLRAAAGLGA-GIP 522
               G     G    PG+G+ PG+    G  G+A    S  +   K  +      G+ G+ 
Sbjct: 1041 GDKGAKGEKGQAGPPGIGI-PGLRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLK 1099

Query: 523  GLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGG 582
            G    VG PG     G+PG     G+PG   +PG        K  A +PG  G  G  G 
Sbjct: 1100 GSPGSVGYPG---SPGLPGEKGDKGLPGLDGIPG-------VKGEAGLPGTPGPTGPAGQ 1149

Query: 583  VGIPGGVVGAGPAAAAAAAKAAAKAAQF-GLVGAAGLGGLGVGGLGVPGVGGLGGIPPAA 641
             G PG      P +A    +       F G  GA G  G   G +G PG+ G  GIP   
Sbjct: 1150 KGEPGS--DGIPGSAGEKGEPGLPGRGFPGFPGAKGDKG-SKGEVGFPGLAGSPGIP--- 1203

Query: 642  AAKAAKYGVAARPGFGLSPIFPG 664
                 + G    PG    P  PG
Sbjct: 1204 -GSKGEQGFMGPPGPQGQPGLPG 1225



 Score =  162 bits (410), Expect = 9e-40
 Identities = 226/724 (31%), Positives = 282/724 (38%), Gaps = 118/724 (16%)

Query: 23   PSRPG--GVPGAIPGGVPGGVFYPALG-PGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPG 79
            P RPG  G+PG    GV G    P +G PG K L  +PG     G    +G        G
Sbjct: 713  PGRPGFNGLPGN--PGVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHG 770

Query: 80   ALVPGGVADAAA--AYKAAKAGAGLGGVPGVGGLGVSA--GAVVPQPGAGVKPGKVPGVG 135
            A+ P G+                G  GVPG+G  G     G   P PG    PG     G
Sbjct: 771  AIGPPGLQGIRGEPGPPGLPGSVGSPGVPGIGPPGARGPPGGQGP-PGLSGPPGIKGEKG 829

Query: 136  LPGVYPGGVLPGARFP-GVGVLPGVPTGAGVKPKAPGVGGAFAGIPG-------VGPFGG 187
             PG +PG  +PG +   G   LPG+ TG    P  PG  GA  GIPG       +G  G 
Sbjct: 830  FPG-FPGLDMPGPKGDKGAQGLPGI-TGQSGLPGLPGQQGA-PGIPGFPGSKGEMGVMGT 886

Query: 188  P-QPGVPLGYPIKAPKLPG---GYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQ 243
            P QPG P   P+ AP LPG    +G P ++G      G  G+ G  G  G P   G   +
Sbjct: 887  PGQPGSP--GPVGAPGLPGEKGDHGFPGSSGPR----GDPGLKGDKGDVGLPGKPGSMDK 940

Query: 244  AAAAAAAKAAAKFGA-GAAGVLPGVGGAGVPGVPGAIPGIGGIAGV-------GTPAAAA 295
                +        G  G  G +   G  G PG PG +PG  G AG        G P  + 
Sbjct: 941  VDMGSMKGQKGDQGEKGQIGPIGEKGSRGDPGTPG-VPGKDGQAGQPGQPGPKGDPGISG 999

Query: 296  AAAAAAKAAKYGAAAGL-VPGGPGFGPGVVGVPGA-GVPGV-GVPGA----GIPVVPGAG 348
               A       G+  G+ +PG PG   GV G+PG  G PG+ G  GA    G    PG G
Sbjct: 1000 TPGAPGLPGPKGSVGGMGLPGTPG-EKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGIG 1058

Query: 349  IPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVA 408
            IPG  + G    +  A       + G +  +G+ G+P    G  G PG  VG  G PG+ 
Sbjct: 1059 IPG--LRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPG-SPGLKGSPG-SVGYPGSPGLP 1114

Query: 409  GVPGVGGVPGVGGVPGV----GI----SPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGV 460
            G  G  G+PG+ G+PGV    G+     P   A    +    G +PG     G    PG 
Sbjct: 1115 GEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGPAGQKGEPGSDG-IPGSAGEKGEPGLPGR 1173

Query: 461  GVAPGVGLAPGVGVAPGVGVAPGVGVAPGI-------------GPGGVAAAAKSAAKVAA 507
            G  PG   A G   + G    PG+  +PGI             GP G      S      
Sbjct: 1174 GF-PGFPGAKGDKGSKGEVGFPGLAGSPGIPGSKGEQGFMGPPGPQGQPGLPGSPGHATE 1232

Query: 508  KAQLRAAAGLGAGIPGLGVGVGVPGL----GVGA--------GVPGLGVGAGVPGFGAVP 555
              +         G+PGL   +G PGL    GV          G PG+    G PGF  +P
Sbjct: 1233 GPKGDRGPQGQPGLPGLPGPMGPPGLPGIDGVKGDKGNPGWPGAPGVPGPKGDPGFQGMP 1292

Query: 556  G-----ALAAAKAAKYGAAVPGVLG--GLGALGGV-------GIPGGVVGAGPAAAAAAA 601
            G      +  +K       VPG  G  GL  L G+       G+PG     GP       
Sbjct: 1293 GIGGSPGITGSKGDMGPPGVPGFQGPKGLPGLQGIKGDQGDQGVPGAKGLPGPPGPPGPY 1352

Query: 602  KAAAKAAQFGLVGAAGLGGL-GVGGL----GVPGVGGLGGIPPAAAAKAAKYGVAARPGF 656
                   + GL G  G  GL G+ GL    G  GV GL GIP          G    PGF
Sbjct: 1353 DII--KGEPGLPGPEGPPGLKGLQGLPGPKGQQGVTGLVGIP----------GPPGIPGF 1400

Query: 657  GLSP 660
              +P
Sbjct: 1401 DGAP 1404



 Score =  141 bits (355), Expect = 2e-33
 Identities = 212/697 (30%), Positives = 260/697 (37%), Gaps = 181/697 (25%)

Query: 26   PGGVPGAIPGGVPGGVFYPALGPGGKPLKPV---PGGLAGAGLGAGLGAFPAVTFPGALV 82
            P G+PG++  G PG    P +GP G    P    P GL+G     G   FP   FPG  +
Sbjct: 786  PPGLPGSV--GSPG---VPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPG--FPGLDM 838

Query: 83   PGGVADAAAAYKAAKAGA-------GLGGVPGVGGLGVSAG--AVVPQPGAGVKPGKVPG 133
            PG   D  A       G        G  G PG+ G   S G   V+  PG    PG V  
Sbjct: 839  PGPKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGEMGVMGTPGQPGSPGPVGA 898

Query: 134  VGLPGVYPGGVLPGARFP----------GVGVLPGVP----------------------- 160
             GLPG       PG+  P          G   LPG P                       
Sbjct: 899  PGLPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQ 958

Query: 161  ------TGAGVKPKAPGVGG--AFAGIPGV-GPFGGP----QPGVPLGYPIKAPK-LPGG 206
                   G+   P  PGV G    AG PG  GP G P     PG P G P   PK   GG
Sbjct: 959  IGPIGEKGSRGDPGTPGVPGKDGQAGQPGQPGPKGDPGISGTPGAP-GLP--GPKGSVGG 1015

Query: 207  YGLPYTTGKL-------PYGY----GPGGVAGAAGKAGYPTGTGV-------GPQAAAAA 248
             GLP T G+        P G     G  G  G  G+AG P G G+       G Q  A  
Sbjct: 1016 MGLPGTPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAG-PPGIGIPGLRGEKGDQGIAGF 1074

Query: 249  AAKAAAKFGAGAAGV--LPG----------VGGAGVPGVPG-----AIPGIGGIAGV--- 288
                  K   G+ G+  +PG          VG  G PG+PG      +PG+ GI GV   
Sbjct: 1075 PGSPGEKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGE 1134

Query: 289  -GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPG-------------V 334
             G P        A +  + G+    +PG  G   G  G+PG G PG             V
Sbjct: 1135 AGLPGTPGPTGPAGQKGEPGSDG--IPGSAG-EKGEPGLPGRGFPGFPGAKGDKGSKGEV 1191

Query: 335  GVPG-AGIPVVPGA-------GIPGA-AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIP 385
            G PG AG P +PG+       G PG    PG+      A    K  + G +   G+ G+P
Sbjct: 1192 GFPGLAGSPGIPGSKGEQGFMGPPGPQGQPGLPGSPGHATEGPKGDR-GPQGQPGLPGLP 1250

Query: 386  TYGVGAGGFPGF-GV----------GVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAA 434
               +G  G PG  GV          G  G+PG  G PG  G+PG+GG PG+         
Sbjct: 1251 G-PMGPPGLPGIDGVKGDKGNPGWPGAPGVPGPKGDPGFQGMPGIGGSPGI--------- 1300

Query: 435  AAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG-IGPG 493
                 +K  + P     PGV   PG     G+    G+    G    PG    PG  GP 
Sbjct: 1301 ---TGSKGDMGP-----PGV---PGFQGPKGLPGLQGIKGDQGDQGVPGAKGLPGPPGPP 1349

Query: 494  GVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGA 553
            G     K    +          GL  G+PG     GV GL    G+PG     G+PGF  
Sbjct: 1350 GPYDIIKGEPGLPGPEGPPGLKGL-QGLPGPKGQQGVTGL---VGIPG---PPGIPGFDG 1402

Query: 554  VPGALAAAKAAKYGAAVP-GVLGGLGALGGVGIPGGV 589
             PG     +  + G A P G  G  G  G  G+PG +
Sbjct: 1403 APG-----QKGEMGPAGPTGPRGFPGPPGPDGLPGSM 1434



 Score =  132 bits (332), Expect = 1e-30
 Identities = 209/702 (29%), Positives = 257/702 (36%), Gaps = 103/702 (14%)

Query: 22  HPSRPG--GVPGAI----PGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAV 75
           +P  PG  G+PG      P G+PG       G  G+     P GL G     G    P +
Sbjct: 101 YPGNPGLPGIPGQDGPPGPPGIPG-----CNGTKGERGPLGPPGLPGFAGNPGPPGLPGM 155

Query: 76  TF-PGAL---VPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQ--PGAGVKPG 129
              PG +   VPG +      +       G  G+PG+ G     G   P   PG    PG
Sbjct: 156 KGDPGEILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPG 215

Query: 130 KVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAP-------GVGG--AFAGIP 180
           +   +GL    P G        GV   PGVP  A V+ K         G  G   F G+P
Sbjct: 216 EKGQMGLSFQGPKG---DKGDQGVSGPPGVPGQAQVQEKGDFATKGEKGQKGEPGFQGMP 272

Query: 181 GVGPFGGPQPGVPLGYPIK--------APKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKA 232
           GVG  G P    P G P K        +P  PG  G P   G+     GP G  G AG  
Sbjct: 273 GVGEKGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGR----QGPQGEKGEAGPP 328

Query: 233 GYP-TGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTP 291
           G P    G GP        +   +   G  G     G  G PG+PG  PG  G+   G  
Sbjct: 329 GPPGIVIGTGP------LGEKGERGYPGTPGPRGEPGPKGFPGLPGQ-PGPPGLPVPGQA 381

Query: 292 AAAAAAAAAAKAAKYGAAAGLVPGGPGFG--PGVVGVPGA-GVPGV---------GVPG- 338
            A        +    G     +PG  G    PG  G PG  G PG          G PG 
Sbjct: 382 GAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNGIVECQPGPPGD 441

Query: 339 AGIPVVPGAGIPG-AAVPGVVSPEAAAKAAAKAAKYGARPG-------VGVGGIPTYGVG 390
            G P +PG   PG     G    +  +        Y   PG       +G  G P    G
Sbjct: 442 QGPPGIPGQ--PGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPG-AKG 498

Query: 391 AGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPG---VGISPEAQAAAAAKAAKYGLV-- 445
             G PG   GV G+PG  G PG+ G PG  G PG     +  +          + G+   
Sbjct: 499 DRGLPGRD-GVAGVPGPQGTPGLIGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMTGR 557

Query: 446 ---PGVGVAPGVGVAPGVGVAPG-VGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKS 501
              PG    PG+   PG   +PG VGL    G   GVG     G     GP G       
Sbjct: 558 AGSPGRDGHPGL---PGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYG----P 610

Query: 502 AAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAA 561
           A  +  K Q  A    G G PGL    G PG  V   +PG     G+PG    PG     
Sbjct: 611 AGPIGDKGQ--AGFPGGPGSPGLPGPKGEPGKIV--PLPGPPGAEGLPGSPGFPGP-QGD 665

Query: 562 KAAKYGAAVPGVLGGLGALG--GVGIPG--GVVGA-GPAAAAAAAKAAAKAAQFGLVGAA 616
           +        PG+ G  GA+G  G+G PG  G  G  G            +    GL G  
Sbjct: 666 RGFPGTPGRPGLPGEKGAVGQPGIGFPGPPGPKGVDGLPGDMGPPGTPGRPGFNGLPGNP 725

Query: 617 GL-GGLGVGGLGVPGVGGLGGIP--PAAAAKAAKYGVAARPG 655
           G+ G  G  G+G+PG+ GL G+P  P    +    GV   PG
Sbjct: 726 GVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPG 767



 Score =  114 bits (286), Expect = 2e-25
 Identities = 148/475 (31%), Positives = 183/475 (38%), Gaps = 95/475 (20%)

Query: 23   PSRPG--------GVPGA--IPG--GVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLG 70
            P +PG        G PGA  +PG  G  GG+  P   PG K +  +PG     GL    G
Sbjct: 986  PGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGT-PGEKGVPGIPGPQGSPGLPGDKG 1044

Query: 71   AFPA---VTFPGALVPG--------GVAD--AAAAYKAAKAGAGLGGVPGVGGLGVSAGA 117
            A         PG  +PG        G+A    +   K  K   G+ G+PG  GL  S G+
Sbjct: 1045 AKGEKGQAGPPGIGIPGLRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLKGSPGS 1104

Query: 118  VVPQPGAGVKPGK-----VPGV-GLPGVYPGGVLPGARFP-------GVGVLPGVPTGAG 164
            V   PG+   PG+     +PG+ G+PGV     LPG   P       G     G+P  AG
Sbjct: 1105 V-GYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAG 1163

Query: 165  VKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGG 224
             K +    G  F G PG     G +  V        P L G  G+P + G+  +  GP G
Sbjct: 1164 EKGEPGLPGRGFPGFPGAKGDKGSKGEVGF------PGLAGSPGIPGSKGEQGF-MGPPG 1216

Query: 225  VAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGV--LPGVGGA----GVPGVPGA 278
              G  G  G P     GP+       +       G  G   LPG+ G     G PG PGA
Sbjct: 1217 PQGQPGLPGSPGHATEGPKGDRGPQGQPGLPGLPGPMGPPGLPGIDGVKGDKGNPGWPGA 1276

Query: 279  IPGIGGIAG----VGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA-GVPG 333
             PG+ G  G     G P    +          G      PG PGF  G  G+PG  G+ G
Sbjct: 1277 -PGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGP-----PGVPGF-QGPKGLPGLQGIKG 1329

Query: 334  ----VGVPGA-GIPVVPGA--------GIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVG 380
                 GVPGA G+P  PG         G PG  +PG   P             G +   G
Sbjct: 1330 DQGDQGVPGAKGLPGPPGPPGPYDIIKGEPG--LPGPEGPPGLKGLQGLPGPKGQQGVTG 1387

Query: 381  VGGIPTYGVGAGGFPGFG-----------VGVGGIPGVAGVPGVGGVPGVGGVPG 424
            + GIP    G  G PGF             G  G  G  G PG  G+PG  G PG
Sbjct: 1388 LVGIP----GPPGIPGFDGAPGQKGEMGPAGPTGPRGFPGPPGPDGLPGSMGPPG 1438



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 156/537 (29%), Positives = 181/537 (33%), Gaps = 113/537 (21%)

Query: 201 PKLPGGYGLPYTTGKLPYG-YGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGA 258
           P L G  G P   G  P G  GP G  G  G+ G P   G  GP                
Sbjct: 54  PGLQGVIGFPGMQG--PEGPQGPPGQKGDTGEPGLPGTKGTRGPP--------------- 96

Query: 259 GAAGVLPGVGGAGVPGVPG--------AIPGIGGIAG----VGTPAAAAAA------AAA 300
           GA+G     G  G+PG+PG         IPG  G  G    +G P     A         
Sbjct: 97  GASGY---PGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLP 153

Query: 301 AKAAKYGAAAGLVPG----GPGFGPGVVGVPG-AGVPG----VGVPG-AGIPVVPG-AGI 349
                 G   G VPG    G    PG+ G PG  G+PG    VG PG  G P  PG  G 
Sbjct: 154 GMKGDPGEILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGP 213

Query: 350 PG------------------------AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIP 385
           PG                          VPG    +     A K  K G +   G  G+P
Sbjct: 214 PGEKGQMGLSFQGPKGDKGDQGVSGPPGVPGQAQVQEKGDFATKGEK-GQKGEPGFQGMP 272

Query: 386 TYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGV-GI----SPEAQAAAAAKAA 440
             GVG  G PG   G  G PG  G  G  G PG  G PG  G+     P+ +   A    
Sbjct: 273 --GVGEKGEPG-KPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGPPG 329

Query: 441 KYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAK 500
             G+V G G     G   G    PG    PG    PG+   PG    PG+   G A A  
Sbjct: 330 PPGIVIGTGPLGEKG-ERGYPGTPGPRGEPGPKGFPGLPGQPG---PPGLPVPGQAGAPG 385

Query: 501 SAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGF-GAVPGALA 559
              +   K           G P    G  +PG     G+PG     G PG  G   G + 
Sbjct: 386 FPGERGEKGD--------RGFP----GTSLPGPSGRDGLPGPPGSPGPPGQPGYTNGIVE 433

Query: 560 AAKAAKYGAAVPGVLGGLGALGGVGIPG---------GVVG-AGPAAAAAAAKAAAKAAQ 609
                      PG+ G  G +G +G  G          + G  GP              Q
Sbjct: 434 CQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQ 493

Query: 610 FGLVGAAGLGGL-GVGGL-GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
            G  G  GL G  GV G+ G  G  GL G P A       Y      G    P FPG
Sbjct: 494 PGAKGDRGLPGRDGVAGVPGPQGTPGLIGQPGAKGEPGEFYFDLRLKGDKGDPGFPG 550



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 112/372 (30%), Positives = 140/372 (37%), Gaps = 62/372 (16%)

Query: 3    GLTAAAPRPGVLLLLLSILHPSRPG--------GVPG--AIPG-----GVPGGVFYPALG 47
            G+      PG+     S+ +P  PG        G+PG   IPG     G+PG       G
Sbjct: 1088 GIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGTP--GPTG 1145

Query: 48   PGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPG 107
            P G+  +P   G+ G+    G    P   FPG   PG   D  +  K      GL G PG
Sbjct: 1146 PAGQKGEPGSDGIPGSAGEKGEPGLPGRGFPG--FPGAKGDKGS--KGEVGFPGLAGSPG 1201

Query: 108  VGGLGVSAGAVVP-----QPGAGVKPGKVP----GVGLPGVYPGGVLPGARFPGVGVLPG 158
            + G     G + P     QPG    PG       G   P   PG  LPG   PG    PG
Sbjct: 1202 IPGSKGEQGFMGPPGPQGQPGLPGSPGHATEGPKGDRGPQGQPG--LPG--LPGPMGPPG 1257

Query: 159  VPTGAGVK--------PKAPGVGG-----AFAGIPGVGPFGGPQPGVPLGYPIKAPKLPG 205
            +P   GVK        P APGV G      F G+PG+G   G         P   P   G
Sbjct: 1258 LPGIDGVKGDKGNPGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGPPGVPGFQG 1317

Query: 206  GYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGAGAAGVL 264
              GLP          G  G+ G  G  G P   G+ GP            + G       
Sbjct: 1318 PKGLP----------GLQGIKGDQGDQGVPGAKGLPGPPGPPGPYDIIKGEPGLPGPEGP 1367

Query: 265  PGVGGA-GVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPG 322
            PG+ G  G+PG  G   G+ G+ G+ G P       A  +  + G A    P G    PG
Sbjct: 1368 PGLKGLQGLPGPKGQ-QGVTGLVGIPGPPGIPGFDGAPGQKGEMGPAGPTGPRGFPGPPG 1426

Query: 323  VVGVPGA-GVPG 333
              G+PG+ G PG
Sbjct: 1427 PDGLPGSMGPPG 1438



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 112/386 (29%), Positives = 137/386 (35%), Gaps = 99/386 (25%)

Query: 291 PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGP----GVVGVPGA-GVPGVGVPGAGIPVVP 345
           PAA       ++AA  G  AG      G G     GV G  G  G+PG+           
Sbjct: 13  PAALLLHEEHSRAAAKGGCAG-----SGCGKCDCHGVKGQKGERGLPGL----------- 56

Query: 346 GAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGV----GVGGIPTYGVGAGGFPGFGVGV 401
             G+ G   PG+  PE       +    G  PG+    G  G P    GA G+PG     
Sbjct: 57  -QGVIG--FPGMQGPEGPQGPPGQKGDTG-EPGLPGTKGTRGPP----GASGYPGN---- 104

Query: 402 GGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVG 461
              PG+ G+PG  G PG  G+PG             K  +  L P     PG+   PG  
Sbjct: 105 ---PGLPGIPGQDGPPGPPGIPGCN---------GTKGERGPLGP-----PGL---PGFA 144

Query: 462 VAPGVGLAPGVGVAPG--VGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGA 519
             PG    PG+   PG  +G  PG+                          L+   G   
Sbjct: 145 GNPGPPGLPGMKGDPGEILGHVPGM-------------------------LLKGERGF-P 178

Query: 520 GIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGA 579
           GIPG     G+PGL    G PG     G PG    PG     +  + G +  G  G  G 
Sbjct: 179 GIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPG-----EKGQMGLSFQGPKGDKGD 233

Query: 580 LGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL-GVGGLGVPGVGGLGGIP 638
            G  G PG     G A        A K  + G  G  G  G+ GVG  G PG  G  G P
Sbjct: 234 QGVSGPPG---VPGQAQVQEKGDFATKGEK-GQKGEPGFQGMPGVGEKGEPGKPGPRGKP 289

Query: 639 PAAAAKAAKYGVAARPGFGLSPIFPG 664
                K    G    PGF   P +PG
Sbjct: 290 ----GKDGDKGEKGSPGFPGEPGYPG 311


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score =  169 bits (429), Expect = 6e-42
 Identities = 218/686 (31%), Positives = 250/686 (36%), Gaps = 94/686 (13%)

Query: 26  PGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGG 85
           P G PG  P G PG   +P   PG    +  PG    AG     G       PGA+ P G
Sbjct: 175 PAGPPG--PPGPPGTSGHPG-SPGSPGYQGPPGEPGQAGPSGPPGP------PGAIGPSG 225

Query: 86  VA--DAAAAYKAAKAGAGLGGVPGVGGLGVSAG--AVVPQPGAGVKPGKVPGVGLPGVYP 141
            A  D  +         GL G PG+ G     G   +    G   + G+    G PG+  
Sbjct: 226 PAGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKG 285

Query: 142 GGVLPGAR-FPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKA 200
              LPG    PG     G P   G +P  PG  GA       G  G P P  P       
Sbjct: 286 ENGLPGENGAPGPMGPRGAPGERG-RPGLPGAAGARGNDGARGSDGQPGPPGP------- 337

Query: 201 PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGAG 259
              PG  G P + G      G  G AG+ G  G P   G  GPQ  A A          G
Sbjct: 338 ---PGTAGFPGSPG----AKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGING 390

Query: 260 AAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGF 319
           + G    +G AG+PG PG +   G     G   A      A +  K GA     P G   
Sbjct: 391 SPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERG 450

Query: 320 GPGVVGVPGA----------GVPGV-GVPGA----GIPVVPGA----GIPGAAVP----G 356
             G+ GVPGA          G PG  G+PGA    G P   G     GIPG   P    G
Sbjct: 451 EAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERG 510

Query: 357 VVSPEAAAKAAAKAAKYGARPGVGVGGIP--TYGVGAGGFPG--FGVGVGGIPGVAGVPG 412
              P     AA +  + G   G G+ G+P    G G+ G PG     G  G PG  G  G
Sbjct: 511 APGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSG 570

Query: 413 VGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLV--PGVGVAPGVGVAPGVGVAPGV---- 466
             G PGV G PG    P+    A  K  + G    PG    PG     G    PG     
Sbjct: 571 PRGQPGVMGFPG----PKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPG 626

Query: 467 ----GLAP----GVGVAPGVGVAPGVGVAPG-IGPGGVAAA--AKSAAKVAAKAQLRAAA 515
                  P    G+   PG G  PG    PG  GP G A A  A      A     R   
Sbjct: 627 GDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPP 686

Query: 516 GLGAGIPGLGVGVGVPGLGVG---AGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPG 572
           GL AG PGL  G G PG   G   AG PG    AG PG   +PG        + G   PG
Sbjct: 687 GL-AGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPG-------ERGGLGSPG 738

Query: 573 VLGGLGALGGV---GIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVP 629
             G  G  GG    G+PG     GP         A +    G  GA GL G+  G  G P
Sbjct: 739 PKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGI-AGPRGSP 797

Query: 630 GVGGLGGIPPAAAAKAAKYGVAARPG 655
           G  G  G PP  A      G    PG
Sbjct: 798 GERGETG-PPGPAGFPGAPGQNGEPG 822



 Score =  165 bits (418), Expect = 1e-40
 Identities = 218/680 (32%), Positives = 246/680 (36%), Gaps = 82/680 (12%)

Query: 23  PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALV 82
           PS P G PGAI    P G      G  G+P +P   GL G     G    P   FPG   
Sbjct: 211 PSGPPGPPGAIGPSGPAG----KDGESGRPGRPGERGLPGPPGIKGPAGIPG--FPGMKG 264

Query: 83  PGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPG 142
             G  D     K      GL G  G+ G   + G + P+ GA   PG+    GLPG    
Sbjct: 265 HRGF-DGRNGEKGETGAPGLKGENGLPGENGAPGPMGPR-GA---PGERGRPGLPGAAGA 319

Query: 143 GVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGP----QPGVPLGY-- 196
               GAR       P  P G    P +PG  G        G  G P    +PG P G+  
Sbjct: 320 RGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPG-PQGHAG 378

Query: 197 PIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKF 256
               P  PG  G P   G++    GP G+ GA G  G       GP   A A      + 
Sbjct: 379 AQGPPGPPGINGSPGGKGEM----GPAGIPGAPGLMG-----ARGPPGPAGANGAPGLRG 429

Query: 257 GAGAAGV-----LPGV----GGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYG 307
           GAG  G       PG     G AG+PGVPGA    G     G P A     AA +    G
Sbjct: 430 GAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGER---G 486

Query: 308 AAAGLVPGGPGFGPGVVGVPG-AGVPG-------VGVPGA-GIPVVPG-AGIPGA----- 352
           A     P GP   PG  G  G  G PG        G PG  G+P  PG  G+PG+     
Sbjct: 487 APGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPG 546

Query: 353 --AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGI--PTYGVGAGGFPGFGVGVGGIPGVA 408
               PG    +  +         G R   GV G   P    GA G  G   G GG PG  
Sbjct: 547 SDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGG-PGPQ 605

Query: 409 GVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGL--VPGVGVAPGVGVAPGV------ 460
           G PG  G  G  G PG    P             GL  +PG G  PG    PG       
Sbjct: 606 GPPGKNGETGPQGPPG-PTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGD 664

Query: 461 GVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGA- 519
             APG     G   APG    PG+  APG+  G      +     A       AAG    
Sbjct: 665 AGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGL 724

Query: 520 -GIPGLGVGVGVPGLGVGAGVPGLGVGA-GVPGFGAVPGALAAAKAAKYGAAVPGVLGGL 577
            G+PG   G+G PG     G PG G GA GVPG     G              PG  G  
Sbjct: 725 QGMPGERGGLGSPGPKGDKGEPG-GPGADGVPGKDGPRGPTGP-------IGPPGPAGQP 776

Query: 578 GALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL--GVGGLGVPGVGGLG 635
           G  G  G PG    AGP  +             G  GA G  G   G G  G PG  G G
Sbjct: 777 GDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEG 836

Query: 636 GIPPAAAAKAAKYGVAARPG 655
           G PP  A      G A  PG
Sbjct: 837 G-PPGVAGPPGGSGPAGPPG 855



 Score =  159 bits (401), Expect = 1e-38
 Identities = 210/653 (32%), Positives = 242/653 (37%), Gaps = 83/653 (12%)

Query: 23   PSRPGGVPGAI--PG-----GVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAV 75
            P+ PGG  G    PG     G+PG    P  G  GKP +P P G AGA            
Sbjct: 622  PTGPGGDKGDTGPPGPQGLQGLPGTGGPP--GENGKPGEPGPKGDAGA------------ 667

Query: 76   TFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVK--PGKVPG 133
              PGA  PGG  DA A     +   GL G PG+ G    AG   P+ G G    PG    
Sbjct: 668  --PGA--PGGKGDAGAP--GERGPPGLAGAPGLRG---GAGPPGPEGGKGAAGPPGPPGA 718

Query: 134  VGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVP 193
             G PG+     +PG R  G+G  PG P G   +P  PG  G        GP G   P  P
Sbjct: 719  AGTPGLQG---MPGER-GGLGS-PG-PKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGP 772

Query: 194  LGYPIKAPKLPGGY-GLPYTTGKLPYGY-GPGGVAGAAGKAGYPTGTGVGPQAAAAAAAK 251
             G P    K  GG  GLP   G  P G  G  G  G  G AG+P   G   +        
Sbjct: 773  AGQP--GDKGEGGAPGLPGIAG--PRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERG 828

Query: 252  AAAKFGAGAA-GVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAA 310
            A  + G G   GV    GG+G  G PG     G     G P AA    A       G+  
Sbjct: 829  APGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNG 888

Query: 311  GLVPGGPGFGPGVVGVPG-AGVPGV-GVPGAGIPVVPGAGIPGA-AVPGVVSPEAAAKAA 367
               P GP   PG  G PG AG  G  G PG   P    AG PG    PG   P  A    
Sbjct: 889  NPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPK-GDAGQPGEKGSPGAQGPPGAPGPL 947

Query: 368  AKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGI 427
              A   GAR   G  G+P    G  G PG      G+ G +G PG  G+ G  G PG   
Sbjct: 948  GIAGITGARGLAGPPGMP----GPRGSPG----PQGVKGESGKPGANGLSGERGPPG--- 996

Query: 428  SPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVA 487
             P+     A  A +    PG    PG    PG   +PG     G   +PG   APG    
Sbjct: 997  -PQGLPGLAGTAGE----PGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGP 1051

Query: 488  PG-IGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGA 546
            PG +GP G  +  +  +  A  A     AG   G PG     G  G     G  G+    
Sbjct: 1052 PGPVGPAG-KSGDRGESGPAGPAGAPGPAG-SRGAPGPQGPRGDKGETGERGAAGIKGHR 1109

Query: 547  GVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAK 606
            G PG    PG+             PG  G  GA+G  G  G     GP+        +  
Sbjct: 1110 GFPGNPGAPGS-------------PGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGH 1156

Query: 607  AAQFGLVGAAGLGGL--GVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFG 657
                G  G  G  G     G  G PG  G  G P A        G AA  G G
Sbjct: 1157 PGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAGIG 1209



 Score =  126 bits (317), Expect = 6e-29
 Identities = 171/533 (32%), Positives = 199/533 (37%), Gaps = 91/533 (17%)

Query: 160 PTGAGVKPKAPGVGGAFAGIPGV-GPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPY 218
           P G    P  PG+ G   G PG+ G  G P    P G     P  P  Y   Y +  +  
Sbjct: 104 PQGPKGDPGPPGIPGR-NGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKS 162

Query: 219 GYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGA 278
           G   GG+AG  G AG P     GP                G +G     G  G  G PG 
Sbjct: 163 GVAVGGLAGYPGPAGPP-----GPPGP------------PGTSGHPGSPGSPGYQGPPGE 205

Query: 279 IPGIGGIAG-VGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFG--PGVVGVPG-AGVPGV 334
            PG  G +G  G P A   +  A K  + G      PG PG    PG  G+ G AG+PG 
Sbjct: 206 -PGQAGPSGPPGPPGAIGPSGPAGKDGESGR-----PGRPGERGLPGPPGIKGPAGIPGF 259

Query: 335 -GVPG-------------AGIPVVPGA-GIPGA-AVPGVVSPEAA---------AKAAAK 369
            G+ G              G P + G  G+PG    PG + P  A           AA  
Sbjct: 260 PGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGA 319

Query: 370 AAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISP 429
               GAR   G  G P    G  GFPG   G  G  G AG PG  G PG  G PG    P
Sbjct: 320 RGNDGARGSDGQPG-PPGPPGTAGFPG-SPGAKGEVGPAGSPGSNGAPGQRGEPG----P 373

Query: 430 EAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG 489
           +  A A          PG+  +PG     G    PG   APG+  A G     G   APG
Sbjct: 374 QGHAGAQGPPGP----PGINGSPGGKGEMGPAGIPG---APGLMGARGPPGPAGANGAPG 426

Query: 490 IGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVP 549
           +  GG     K+ AK   +   R   G  AGIP      GVPG     G  G     G P
Sbjct: 427 L-RGGAGEPGKNGAK--GEPGPRGERG-EAGIP------GVPG---AKGEDGKDGSPGEP 473

Query: 550 GFGAVPGALAAAKAAKY-GAAVP-GVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKA 607
           G   +PGA     A  + G A P G+ G  G  G  G PG    AGP  AA         
Sbjct: 474 GANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPG---PAGPRGAAGEPGRDGVP 530

Query: 608 AQFGLVGAAGLGGLGVGGLGVPGVGGLGGI-----PPAAAAKAAKYGVAARPG 655
              G+ G  G  G G G  G PG  G  G      PP  +    + GV   PG
Sbjct: 531 GGPGMRGMPGSPG-GPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPG 582



 Score =  125 bits (314), Expect = 1e-28
 Identities = 161/523 (30%), Positives = 190/523 (36%), Gaps = 98/523 (18%)

Query: 188 PQPGVPLG-------YPIKAPKLP-------GGYGLPYTTGKLPYGYGPGGVAGAAGKAG 233
           P P +P G        P  AP  P       G  G P   G +P   G  G+ G  G  G
Sbjct: 75  PNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPG-IPGRNGDPGIPGQPGSPG 133

Query: 234 YPTGTGV------GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAG 287
            P   G+      GPQ  +        K G    G+    G AG PG PG  PG  G  G
Sbjct: 134 SPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPGPPGP-PGTSGHPG 192

Query: 288 -VGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG-AGVPG-VGVPG----AG 340
             G+P          +A          P GP   PG +G  G AG  G  G PG     G
Sbjct: 193 SPGSPGYQGPPGEPGQAG---------PSGPPGPPGAIGPSGPAGKDGESGRPGRPGERG 243

Query: 341 IPVVPG----AGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYG-----VGA 391
           +P  PG    AGIPG   PG+           +  + GA    G  G+P        +G 
Sbjct: 244 LPGPPGIKGPAGIPG--FPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMGP 301

Query: 392 GGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVA 451
            G PG   G  G+PG AG  G  G  G  G PG    P       +  AK G V   G +
Sbjct: 302 RGAPG-ERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAK-GEVGPAG-S 358

Query: 452 PGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG----IGPGGVAAAAKSAAKVAA 507
           PG   APG    PG     G    PG    PG+  +PG    +GP G+            
Sbjct: 359 PGSNGAPGQRGEPGPQGHAGAQGPPG---PPGINGSPGGKGEMGPAGI------------ 403

Query: 508 KAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYG 567
                       G PGL    G PG     G PGL  GAG PG     G     +  +  
Sbjct: 404 -----------PGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGE-PGPRGERGE 451

Query: 568 AAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL-----G 622
           A +PGV G  G  G  G P G  GA     AA  + A      G  G AG  G+      
Sbjct: 452 AGIPGVPGAKGEDGKDGSP-GEPGANGLPGAAGERGAP-----GFRGPAGPNGIPGEKGP 505

Query: 623 VGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGG 665
            G  G PG  G    P  AA +  + GV   PG    P  PGG
Sbjct: 506 AGERGAPGPAG----PRGAAGEPGRDGVPGGPGMRGMPGSPGG 544



 Score =  100 bits (248), Expect = 6e-21
 Identities = 149/490 (30%), Positives = 168/490 (34%), Gaps = 94/490 (19%)

Query: 23   PSRPG--GVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGA 80
            P  PG  GVPG      P G   P  GP G+P     GG  G    AG    P     G 
Sbjct: 746  PGGPGADGVPGKDGPRGPTGPIGPP-GPAGQPGDKGEGGAPGLPGIAGPRGSPGER--GE 802

Query: 81   LVPGGVAD--AAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGV-GLP 137
              P G A    A        G G  G PG  G G   G   P  G+G  P   PG  G+ 
Sbjct: 803  TGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSG--PAGPPGPQGVK 860

Query: 138  GVY--PGGVLPGAR-FPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPL 194
            G    PGG  PGA  FPG   LPG P G+   P  PG  G+       GP G    G P 
Sbjct: 861  GERGSPGG--PGAAGFPGARGLPG-PPGSNGNPGPPGPSGSPGKDGPPGPAGNT--GAPG 915

Query: 195  GYPIKAPK----LPGGYGLPYTTGK--LPYGYGPGGVAGAAGKAGYPTGTGV----GPQA 244
               +  PK     PG  G P   G    P   G  G+ GA G AG P   G     GPQ 
Sbjct: 916  SPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQG 975

Query: 245  AAAAAAKAAAKFGAGAAGV-----LPGVGGA-------------GVPGVPGAIPGIGGIA 286
                + K  A   +G  G      LPG+ G              G+PG  G+  G G   
Sbjct: 976  VKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRG 1035

Query: 287  GVGTPAAAAAAA------AAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVP-------- 332
              G+P A  A            A K G      P GP   PG  G  GA  P        
Sbjct: 1036 ENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKG 1095

Query: 333  ------GVGVPG-AGIPVVPGA-GIPGAA-------VPGVVSPEAAAKAAAKAAKYGARP 377
                    G+ G  G P  PGA G PG A        PG   P      +    K G   
Sbjct: 1096 ETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSG 1155

Query: 378  GVGVGGIP--------TYGVGAGGFPGF----------GVGVGGIPGVAGVPGVGGVPGV 419
              G  G P            G+ G PG           G   GG+ G A + G+GG    
Sbjct: 1156 HPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGV-GAAAIAGIGGEKAG 1214

Query: 420  GGVPGVGISP 429
            G  P  G  P
Sbjct: 1215 GFAPYYGDEP 1224


>gi|15890086 type IV collagen alpha 5 isoform 2 precursor [Homo
            sapiens]
          Length = 1691

 Score =  160 bits (405), Expect = 4e-39
 Identities = 217/706 (30%), Positives = 262/706 (37%), Gaps = 137/706 (19%)

Query: 23   PSRPG--GVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAG-------------LGA 67
            P  PG  G PG     +P        GP G P  P   GL G               +G 
Sbjct: 428  PGAPGLPGPPGPAGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGT 487

Query: 68   GLGAFPAVT-FPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGV 126
            G+   P     PG   P G        K  K  AG  G  G+ G+          PGA  
Sbjct: 488  GISGPPGQPGLPGLPGPPGSL-GFPGQKGEKGQAGATGPKGLPGI----------PGAPG 536

Query: 127  KPGKVPGVGLPG---VYPG-----GVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAG 178
             PG     G PG    +PG     G L     PG+  LPG P   G+ P  PG  G   G
Sbjct: 537  APGFPGSKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGL-PGLPGPKGEPGG 595

Query: 179  IPGVGPFGGP-QPGVPLGYPIK-APKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPT 236
            I   G  G P  PG+P G P    P  P G+G P   G+     G  GVAG  G+ G P 
Sbjct: 596  ITFKGERGPPGNPGLP-GLPGNIGPMGPPGFGPPGPVGEK----GIQGVAGNPGQPGIPG 650

Query: 237  GTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGG------IAGVGT 290
              G  P        K       G  G +   G  G+PG PG +PGI G      I G+G 
Sbjct: 651  PKG-DPGQTITQPGKPGLPGNPGRDGDVGLPGDPGLPGQPG-LPGIPGSKGEPGIPGIGL 708

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA-GVPG-VGVPGA-GIPVVPGA 347
            P                      PG  GF PG+ G PGA G PG +G+ G  G P  PG 
Sbjct: 709  PGP--------------------PGPKGF-PGIPGPPGAPGTPGRIGLEGPPGPPGFPGP 747

Query: 348  -GIPGAAVPGVVSPEAAAKAAAKAAKYGAR--------PG-VGVGGIP--TYGVGAGGFP 395
             G PG A+PG   P             G R        PG  G+ G+P     VG  G P
Sbjct: 748  KGEPGFALPGPPGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGDVGPNGQP 807

Query: 396  GF-------GVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGV 448
            G        G+GV G PG  G+PG  G PG+ G+PG    P                PG+
Sbjct: 808  GPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLDVPGPPGERGSPGI 867

Query: 449  GVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAK 508
              APG    PG   +PG+    G    PG     G+   PG  PG +    +S       
Sbjct: 868  PGAPGPIGPPG---SPGLPGKAGASGFPGTKGEMGMMGPPG-PPGPLGIPGRS------- 916

Query: 509  AQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGA----LAAAKAA 564
                       G+PGL    G+ G     G  G     G PG    PG     L  +K  
Sbjct: 917  -----------GVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGE 965

Query: 565  KYGAAVPGVLGGLGALGGVGIPG-----GVVGAGPAAAAAAAKA-AAKAAQFGLVGAAGL 618
            K    +PG+ G  G  G  G+PG     G+ G          K       Q GL+G  GL
Sbjct: 966  KGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGL 1025

Query: 619  GGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
             G  +G +G PG  G+ G PP  +      GV  +PG   SP  PG
Sbjct: 1026 KGT-IGDMGFPGPQGVEG-PPGPS------GVPGQPG---SPGLPG 1060



 Score =  155 bits (393), Expect = 9e-38
 Identities = 209/673 (31%), Positives = 257/673 (38%), Gaps = 95/673 (14%)

Query: 18   LSILHPSRPGGVPGAI--PG--GVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFP 73
            + +  P  P G+PG I  PG  G+PG    P  GP G  +   PG     G+    G   
Sbjct: 818  IGVQGPPGPPGIPGPIGQPGLHGIPGEKGDP--GPPGLDVPGPPGERGSPGIPGAPGPIG 875

Query: 74   AVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG-LGVSAGAVVP----------QP 122
                PG  +PG     A+ +   K   G+ G PG  G LG+   + VP          QP
Sbjct: 876  PPGSPG--LPGKAG--ASGFPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQP 931

Query: 123  GAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGG--AFAGIP 180
            G     G+    G PG+ PG   PG   P +    G     G+ P  PGV G   + G+P
Sbjct: 932  GLPGPTGEKGSKGEPGL-PGP--PGPMDPNLLGSKGEKGEPGL-PGIPGVSGPKGYQGLP 987

Query: 181  GVG--PFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGT 238
            G    P    QPG+P G P   PK  G  GLP   G +    GP G+ G  G  G+P   
Sbjct: 988  GDPGQPGLSGQPGLP-GPP--GPK--GNPGLPGQPGLI----GPPGLKGTIGDMGFPGPQ 1038

Query: 239  GV-GPQAAAAAAAKAAAKFGAGAAGVL--PGVGGAGVPGVPG--------AIPGIGGIAG 287
            GV GP   +    +  +    G  G    PG+   G+PG+PG          PG  GI G
Sbjct: 1039 GVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKG 1098

Query: 288  -VGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG----AGVPG-VGVPGAGI 341
             VG P             +        PG PGF PG  G PG    +G PG  G+PG   
Sbjct: 1099 SVGDPGLPGLPGTPGAKGQ--------PGLPGF-PGTPGPPGPKGISGPPGNPGLPGEPG 1149

Query: 342  PVVPGAGIPGAAVP----GVVSPEAAAKAAAKAAKYGARPGVGVGGIP-----TYGVGAG 392
            PV  G G PG   P    G    +     A +  + G +PG G  G P     +   G G
Sbjct: 1150 PV-GGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPG-QPGFGNPGPPGLPGLSGQKGDG 1207

Query: 393  GFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISP-EAQAAAAAKAAKYGLVPGVGVA 451
            G PG   G  G+PG  G PG  G PGV G PG   SP  A           G  PG    
Sbjct: 1208 GLPGIP-GNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQG-PPGRPGP 1265

Query: 452  PGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGI----GPGGVAAAAKSAAKVAA 507
             G    PG    PG+    G+    G    PG+   PG+    GP G+            
Sbjct: 1266 TGFQGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGM 1325

Query: 508  KAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYG 567
            K           G PGL    G PG+   +GVPG     G PG    PG       +   
Sbjct: 1326 K-----------GDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPGPSGQS 1374

Query: 568  AAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGG-LGVGGL 626
              + G  G  G  G  G+ G     GP              + GL G  G GG  G  GL
Sbjct: 1375 IIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGL 1434

Query: 627  -GVPGVGGLGGIP 638
             G PG  GL G P
Sbjct: 1435 PGQPGTRGLDGPP 1447



 Score =  130 bits (327), Expect = 4e-30
 Identities = 205/733 (27%), Positives = 258/733 (35%), Gaps = 141/733 (19%)

Query: 1   MAGLTAAAPRPGVLLLLLSIL-HPSRPGGVPGAIPG---------GVPGGVFYPAL-GPG 49
           + G++ AA   G+ LL LS+   P+      G  PG         G  G   +P L G  
Sbjct: 3   LRGVSLAA---GLFLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHP 59

Query: 50  GKPLKPVPGGLAGAGLGAGLGAFPAVTFP-GALVPGGVADAAAAYKAAKAGAGLGGVPGV 108
           G P  P P G  G     G    P    P G   P G+              G  G PG+
Sbjct: 60  GLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLP-------------GFPGTPGL 106

Query: 109 GGLGVSAGAVVPQ--PGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVK 166
            G+    GA  PQ  PG     G+    G PG +PG   P    PG+  + G P G+ + 
Sbjct: 107 PGMPGHDGAPGPQGIPGCNGTKGERGFPGSPG-FPGLQGPPGP-PGIPGMKGEP-GSIIM 163

Query: 167 PKAPGVGG--AFAGIPGV----GPFGGPQPGVPLGYP-IKAPKLPGGYGLPYTTGKLPYG 219
              PG  G   + G PG+    GP G P P  P G P +  P  PG  GLP   G +   
Sbjct: 164 SSLPGPKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGP--PGPPGLPGPKGNMGLN 221

Query: 220 Y-GPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAA-AKFGAGAAGVLPGVGGAGVPGVPG 277
           + GP G  G  G  G P     GP    +   +    +F  G  G+    G  G PG+ G
Sbjct: 222 FQGPKGEKGEQGLQGPP-----GPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRG 276

Query: 278 AIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA------- 329
                GG  G  G            K  + G     +PG PG  PG  G PG        
Sbjct: 277 PPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPG--IPGLPG-DPGYPGEPGRDGEKGQK 333

Query: 330 ------GVPGVGVPGAGIPVVPGA-------GIPGA----AVPGVVSPEAAAKAAAKAAK 372
                 G PG+ +P  G  +  G        G+PG       PG+  P            
Sbjct: 334 GDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLP-------- 385

Query: 373 YGARPGVGVGGIPTYGVGAGGFPGF----------GVGVGGIPGVAGVPGVGGVPGVGGV 422
               PG  V G P    G  GFPG           G+ + G PG+ G PG  G+PG  G 
Sbjct: 386 --GPPGAAVMGPP----GPPGFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGP 439

Query: 423 PGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAP 482
            G  I P  +          G     G+    GV    G      +  G+   PG    P
Sbjct: 440 AGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPG---QP 496

Query: 483 GVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPG---------- 532
           G+   PG  PG +    +   K   +A      GL  GIPG     G PG          
Sbjct: 497 GLPGLPG-PPGSLGFPGQKGEK--GQAGATGPKGL-PGIPGAPGAPGFPGSKGEPGDILT 552

Query: 533 ----------LGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGG 582
                     LG   G PGL    G PG   +PG L   K    G    G  G  G  G 
Sbjct: 553 FPGMKGDKGELG-SPGAPGLPGLPGTPGQDGLPG-LPGPKGEPGGITFKGERGPPGNPGL 610

Query: 583 VGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAA 642
            G+PG +   GP                G VG  G+ G+  G  G PG+ G  G P    
Sbjct: 611 PGLPGNIGPMGPPGFGPP----------GPVGEKGIQGV-AGNPGQPGIPGPKGDPGQTI 659

Query: 643 AKAAKYGVAARPG 655
            +  K G+   PG
Sbjct: 660 TQPGKPGLPGNPG 672



 Score =  130 bits (327), Expect = 4e-30
 Identities = 185/617 (29%), Positives = 227/617 (36%), Gaps = 132/617 (21%)

Query: 26   PGGVPGAIPGGVPGGVFYPAL----GPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGAL 81
            P G PG  P G+PG    P L    G  G+P  P P G  G+    GL        PG  
Sbjct: 903  PPGPPG--PLGIPGRSGVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGL--------PGP- 951

Query: 82   VPGGVADAAAAYKAAKAGAGLGGVPGVGG----LGVSAGAVVP----QPGAGVKPGKVPG 133
             PG +       K  K   GL G+PGV G     G+      P    QPG    PG    
Sbjct: 952  -PGPMDPNLLGSKGEKGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGN 1010

Query: 134  VGLPGVYPG--------GVLPGARFPGVGVLPGVPTGAGV--KPKAPGVGGAFA--GIPG 181
             GLPG  PG        G +    FPG   + G P  +GV  +P +PG+ G     G PG
Sbjct: 1011 PGLPG-QPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDPG 1069

Query: 182  VGPFGGP-------QPGVPLGYP--------IKAPKLPGGYGLPYTTGK--------LPY 218
            +   G P       +PG+P GYP        +  P LPG  G P   G+         P 
Sbjct: 1070 ISSIGLPGLPGPKGEPGLP-GYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPG 1128

Query: 219  GYGPGGVAGAAGKAGYPTGTGV----------GPQAAAAAAAKAAAKFGAGAAGVLPGVG 268
              GP G++G  G  G P   G           GP        +      AG  G  PG  
Sbjct: 1129 PPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGE-PGQP 1187

Query: 269  GAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGL--VPGGPGFGPGVVGV 326
            G G PG PG +PG+ G  G G                     GL  +PG PG  PG  G 
Sbjct: 1188 GFGNPGPPG-LPGLSGQKGDG---------------------GLPGIPGNPGL-PGPKGE 1224

Query: 327  PGA-GVPGV----GVPGAGIPVVPGA-------GIPGAAVP----GVVSPEAAAKAAAKA 370
            PG  G PGV    G PG+  P + G        G PG   P    G+  PE         
Sbjct: 1225 PGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGPTGFQGLPGPEGPPGLPGNG 1284

Query: 371  AKYGARPGVGVGGIPTYG--VGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGIS 428
               G +   G  G+P      G  G PG   G  G PG+ G+ G  G+PGV G PG+   
Sbjct: 1285 GIKGEKGNPGQPGLPGLPGLKGDQGPPGLQ-GNPGRPGLNGMKGDPGLPGVPGFPGMK-G 1342

Query: 429  PEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAP 488
            P     +A    + GL+   G  PG+    G  +     +  G    PG+   PG+   P
Sbjct: 1343 PSGVPGSAGPEGEPGLIGPPG-PPGLPGPSGQSI-----IIKGDAGPPGIPGQPGLKGLP 1396

Query: 489  GI-GPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAG 547
            G  GP G+                    GL  G  G G   G PGL    G  GL    G
Sbjct: 1397 GPQGPQGLPGPTGPPGDPGRN-------GL-PGFDGAGGRKGDPGLPGQPGTRGLDGPPG 1448

Query: 548  VPGFGAVPGALAAAKAA 564
              G    PG    +  A
Sbjct: 1449 PDGLQGPPGPPGTSSVA 1465



 Score =  114 bits (285), Expect = 3e-25
 Identities = 148/434 (34%), Positives = 170/434 (39%), Gaps = 54/434 (12%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPG-------GLAGAGLGAGLGAFPAV 75
            P    G PG  P GVPG    P L PG K  K  PG       GL G     GL  +P  
Sbjct: 1037 PQGVEGPPG--PSGVPGQPGSPGL-PGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGN 1093

Query: 76   TFPGALVPGGVADAAA----AYKAAKAGAGLGGVPGVGGLGVSAGAVVP--QPGAGVKPG 129
              PG  + G V D           AK   GL G PG  G     G   P   PG   +PG
Sbjct: 1094 --PG--IKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEPG 1149

Query: 130  KVPGVGLPGVYPGGVLPGARF-PGVGVLPGVPTGAGVKPKAPGVGGAFA-GIPGV-GPFG 186
             V G G PG  PG   PG +  PG   +PG P G   +P  PG G     G+PG+ G  G
Sbjct: 1150 PVGGGGHPG-QPGP--PGEKGKPGQDGIPG-PAGQKGEPGQPGFGNPGPPGLPGLSGQKG 1205

Query: 187  -GPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAA 245
             G  PG+P       P LPG  G P   G  P   GP G  G+ G A        GPQ  
Sbjct: 1206 DGGLPGIPGN-----PGLPGPKGEPGFHG-FPGVQGPPGPPGSPGPALEGPKGNPGPQGP 1259

Query: 246  AAAAAKAAAKFGAGAAGV--LPGVGGA----GVPGVPGAIPGIGGIAGVGTPAAAAAAAA 299
                     +   G  G   LPG GG     G PG PG +PG+ G+ G   P        
Sbjct: 1260 PGRPGPTGFQGLPGPEGPPGLPGNGGIKGEKGNPGQPG-LPGLPGLKGDQGPPGLQGNPG 1318

Query: 300  AAKAAKYGAAAGLVPGGPGFG--PGVVGVPGA----GVPG-VGVPGAGIPVVPGAGIPGA 352
                       GL PG PGF    G  GVPG+    G PG +G PG   P +PG      
Sbjct: 1319 RPGLNGMKGDPGL-PGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGP--PGLPGPSGQSI 1375

Query: 353  AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGI--PTYGVGAGGFPGFGVGVGGIPGVAGV 410
             + G   P             G +   G+ G   P    G  G PGF  G GG  G  G+
Sbjct: 1376 IIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFD-GAGGRKGDPGL 1434

Query: 411  PGVGGVPGVGGVPG 424
            PG  G  G+ G PG
Sbjct: 1435 PGQPGTRGLDGPPG 1448


>gi|4502955 type IV collagen alpha 5 isoform 1 precursor [Homo
            sapiens]
          Length = 1685

 Score =  160 bits (405), Expect = 4e-39
 Identities = 217/706 (30%), Positives = 262/706 (37%), Gaps = 137/706 (19%)

Query: 23   PSRPG--GVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAG-------------LGA 67
            P  PG  G PG     +P        GP G P  P   GL G               +G 
Sbjct: 428  PGAPGLPGPPGPAGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGT 487

Query: 68   GLGAFPAVT-FPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGV 126
            G+   P     PG   P G        K  K  AG  G  G+ G+          PGA  
Sbjct: 488  GISGPPGQPGLPGLPGPPGSL-GFPGQKGEKGQAGATGPKGLPGI----------PGAPG 536

Query: 127  KPGKVPGVGLPG---VYPG-----GVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAG 178
             PG     G PG    +PG     G L     PG+  LPG P   G+ P  PG  G   G
Sbjct: 537  APGFPGSKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGL-PGLPGPKGEPGG 595

Query: 179  IPGVGPFGGP-QPGVPLGYPIK-APKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPT 236
            I   G  G P  PG+P G P    P  P G+G P   G+     G  GVAG  G+ G P 
Sbjct: 596  ITFKGERGPPGNPGLP-GLPGNIGPMGPPGFGPPGPVGEK----GIQGVAGNPGQPGIPG 650

Query: 237  GTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGG------IAGVGT 290
              G  P        K       G  G +   G  G+PG PG +PGI G      I G+G 
Sbjct: 651  PKG-DPGQTITQPGKPGLPGNPGRDGDVGLPGDPGLPGQPG-LPGIPGSKGEPGIPGIGL 708

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA-GVPG-VGVPGA-GIPVVPGA 347
            P                      PG  GF PG+ G PGA G PG +G+ G  G P  PG 
Sbjct: 709  PGP--------------------PGPKGF-PGIPGPPGAPGTPGRIGLEGPPGPPGFPGP 747

Query: 348  -GIPGAAVPGVVSPEAAAKAAAKAAKYGAR--------PG-VGVGGIP--TYGVGAGGFP 395
             G PG A+PG   P             G R        PG  G+ G+P     VG  G P
Sbjct: 748  KGEPGFALPGPPGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGDVGPNGQP 807

Query: 396  GF-------GVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGV 448
            G        G+GV G PG  G+PG  G PG+ G+PG    P                PG+
Sbjct: 808  GPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLDVPGPPGERGSPGI 867

Query: 449  GVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAK 508
              APG    PG   +PG+    G    PG     G+   PG  PG +    +S       
Sbjct: 868  PGAPGPIGPPG---SPGLPGKAGASGFPGTKGEMGMMGPPG-PPGPLGIPGRS------- 916

Query: 509  AQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGA----LAAAKAA 564
                       G+PGL    G+ G     G  G     G PG    PG     L  +K  
Sbjct: 917  -----------GVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGE 965

Query: 565  KYGAAVPGVLGGLGALGGVGIPG-----GVVGAGPAAAAAAAKA-AAKAAQFGLVGAAGL 618
            K    +PG+ G  G  G  G+PG     G+ G          K       Q GL+G  GL
Sbjct: 966  KGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGL 1025

Query: 619  GGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
             G  +G +G PG  G+ G PP  +      GV  +PG   SP  PG
Sbjct: 1026 KGT-IGDMGFPGPQGVEG-PPGPS------GVPGQPG---SPGLPG 1060



 Score =  159 bits (403), Expect = 6e-39
 Identities = 209/672 (31%), Positives = 258/672 (38%), Gaps = 99/672 (14%)

Query: 18   LSILHPSRPGGVPGAI--PG--GVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFP 73
            + +  P  P G+PG I  PG  G+PG    P  GP G  +   PG     G+    G   
Sbjct: 818  IGVQGPPGPPGIPGPIGQPGLHGIPGEKGDP--GPPGLDVPGPPGERGSPGIPGAPGPIG 875

Query: 74   AVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG-LGVSAGAVVP----------QP 122
                PG  +PG     A+ +   K   G+ G PG  G LG+   + VP          QP
Sbjct: 876  PPGSPG--LPGKAG--ASGFPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQP 931

Query: 123  GAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGG--AFAGIP 180
            G     G+    G PG+ PG   PG   P +    G     G+ P  PGV G   + G+P
Sbjct: 932  GLPGPTGEKGSKGEPGL-PGP--PGPMDPNLLGSKGEKGEPGL-PGIPGVSGPKGYQGLP 987

Query: 181  GVG--PFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGT 238
            G    P    QPG+P G P   PK  G  GLP   G +    GP G+ G  G  G+P   
Sbjct: 988  GDPGQPGLSGQPGLP-GPP--GPK--GNPGLPGQPGLI----GPPGLKGTIGDMGFPGPQ 1038

Query: 239  GV-GPQAAAAAAAKAAAKFGAGAAGVL--PGVGGAGVPGVPG--------AIPGIGGIAG 287
            GV GP   +    +  +    G  G    PG+   G+PG+PG          PG  GI G
Sbjct: 1039 GVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKG 1098

Query: 288  -VGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG----AGVPG-VGVPGAGI 341
             VG P             +        PG PGF PG  G PG    +G PG  G+PG   
Sbjct: 1099 SVGDPGLPGLPGTPGAKGQ--------PGLPGF-PGTPGPPGPKGISGPPGNPGLPGEPG 1149

Query: 342  PVVPGAGIPGAAVP----GVVSPEAAAKAAAKAAKYGARPGVGVGGIP-----TYGVGAG 392
            PV  G G PG   P    G    +     A +  + G +PG G  G P     +   G G
Sbjct: 1150 PV-GGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPG-QPGFGNPGPPGLPGLSGQKGDG 1207

Query: 393  GFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAP 452
            G PG   G  G+PG  G PG  G PGV G PG    P      A +  K    PG    P
Sbjct: 1208 GLPGIP-GNPGLPGPKGEPGFHGFPGVQGPPG----PPGSPGPALEGPKGN--PGPQGPP 1260

Query: 453  GVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGI----GPGGVAAAAKSAAKVAAK 508
            G    PG    PG+    G+    G    PG+   PG+    GP G+            K
Sbjct: 1261 GRPGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGMK 1320

Query: 509  AQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGA 568
                       G PGL    G PG+   +GVPG     G PG    PG       +    
Sbjct: 1321 -----------GDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPGPSGQSI 1369

Query: 569  AVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGG-LGVGGL- 626
             + G  G  G  G  G+ G     GP              + GL G  G GG  G  GL 
Sbjct: 1370 IIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGLP 1429

Query: 627  GVPGVGGLGGIP 638
            G PG  GL G P
Sbjct: 1430 GQPGTRGLDGPP 1441



 Score =  133 bits (334), Expect = 6e-31
 Identities = 185/611 (30%), Positives = 227/611 (37%), Gaps = 126/611 (20%)

Query: 26   PGGVPGAIPGGVPGGVFYPAL----GPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGAL 81
            P G PG  P G+PG    P L    G  G+P  P P G  G+    GL        PG  
Sbjct: 903  PPGPPG--PLGIPGRSGVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGL--------PGP- 951

Query: 82   VPGGVADAAAAYKAAKAGAGLGGVPGVGG----LGVSAGAVVP----QPGAGVKPGKVPG 133
             PG +       K  K   GL G+PGV G     G+      P    QPG    PG    
Sbjct: 952  -PGPMDPNLLGSKGEKGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGN 1010

Query: 134  VGLPGVYPG--------GVLPGARFPGVGVLPGVPTGAGV--KPKAPGVGGAFA--GIPG 181
             GLPG  PG        G +    FPG   + G P  +GV  +P +PG+ G     G PG
Sbjct: 1011 PGLPG-QPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDPG 1069

Query: 182  VGPFGGP-------QPGVPLGYP--------IKAPKLPGGYGLPYTTGK--------LPY 218
            +   G P       +PG+P GYP        +  P LPG  G P   G+         P 
Sbjct: 1070 ISSIGLPGLPGPKGEPGLP-GYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPG 1128

Query: 219  GYGPGGVAGAAGKAGYPTGTGV----------GPQAAAAAAAKAAAKFGAGAAGVLPGVG 268
              GP G++G  G  G P   G           GP        +      AG  G  PG  
Sbjct: 1129 PPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGE-PGQP 1187

Query: 269  GAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGL--VPGGPGFGPGVVGV 326
            G G PG PG +PG+ G  G G                     GL  +PG PG  PG  G 
Sbjct: 1188 GFGNPGPPG-LPGLSGQKGDG---------------------GLPGIPGNPGL-PGPKGE 1224

Query: 327  PGA-GVPGV----GVPGAGIPVVPGA-GIPGA----AVPGVVSPEAAAKAAAKAAKYGAR 376
            PG  G PGV    G PG+  P + G  G PG       PG+  PE            G +
Sbjct: 1225 PGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGLPGPEGPPGLPGNGGIKGEK 1284

Query: 377  PGVGVGGIPTYG--VGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAA 434
               G  G+P      G  G PG   G  G PG+ G+ G  G+PGV G PG+   P     
Sbjct: 1285 GNPGQPGLPGLPGLKGDQGPPGLQ-GNPGRPGLNGMKGDPGLPGVPGFPGMK-GPSGVPG 1342

Query: 435  AAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGI-GPG 493
            +A    + GL+   G  PG+    G  +     +  G    PG+   PG+   PG  GP 
Sbjct: 1343 SAGPEGEPGLIGPPG-PPGLPGPSGQSI-----IIKGDAGPPGIPGQPGLKGLPGPQGPQ 1396

Query: 494  GVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGA 553
            G+                    GL  G  G G   G PGL    G  GL    G  G   
Sbjct: 1397 GLPGPTGPPGDPGRN-------GL-PGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQG 1448

Query: 554  VPGALAAAKAA 564
             PG    +  A
Sbjct: 1449 PPGPPGTSSVA 1459



 Score =  130 bits (327), Expect = 4e-30
 Identities = 205/733 (27%), Positives = 258/733 (35%), Gaps = 141/733 (19%)

Query: 1   MAGLTAAAPRPGVLLLLLSIL-HPSRPGGVPGAIPG---------GVPGGVFYPAL-GPG 49
           + G++ AA   G+ LL LS+   P+      G  PG         G  G   +P L G  
Sbjct: 3   LRGVSLAA---GLFLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHP 59

Query: 50  GKPLKPVPGGLAGAGLGAGLGAFPAVTFP-GALVPGGVADAAAAYKAAKAGAGLGGVPGV 108
           G P  P P G  G     G    P    P G   P G+              G  G PG+
Sbjct: 60  GLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLP-------------GFPGTPGL 106

Query: 109 GGLGVSAGAVVPQ--PGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVK 166
            G+    GA  PQ  PG     G+    G PG +PG   P    PG+  + G P G+ + 
Sbjct: 107 PGMPGHDGAPGPQGIPGCNGTKGERGFPGSPG-FPGLQGPPGP-PGIPGMKGEP-GSIIM 163

Query: 167 PKAPGVGG--AFAGIPGV----GPFGGPQPGVPLGYP-IKAPKLPGGYGLPYTTGKLPYG 219
              PG  G   + G PG+    GP G P P  P G P +  P  PG  GLP   G +   
Sbjct: 164 SSLPGPKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGP--PGPPGLPGPKGNMGLN 221

Query: 220 Y-GPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAA-AKFGAGAAGVLPGVGGAGVPGVPG 277
           + GP G  G  G  G P     GP    +   +    +F  G  G+    G  G PG+ G
Sbjct: 222 FQGPKGEKGEQGLQGPP-----GPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRG 276

Query: 278 AIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA------- 329
                GG  G  G            K  + G     +PG PG  PG  G PG        
Sbjct: 277 PPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPG--IPGLPG-DPGYPGEPGRDGEKGQK 333

Query: 330 ------GVPGVGVPGAGIPVVPGA-------GIPGA----AVPGVVSPEAAAKAAAKAAK 372
                 G PG+ +P  G  +  G        G+PG       PG+  P            
Sbjct: 334 GDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLP-------- 385

Query: 373 YGARPGVGVGGIPTYGVGAGGFPGF----------GVGVGGIPGVAGVPGVGGVPGVGGV 422
               PG  V G P    G  GFPG           G+ + G PG+ G PG  G+PG  G 
Sbjct: 386 --GPPGAAVMGPP----GPPGFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGP 439

Query: 423 PGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAP 482
            G  I P  +          G     G+    GV    G      +  G+   PG    P
Sbjct: 440 AGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPG---QP 496

Query: 483 GVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPG---------- 532
           G+   PG  PG +    +   K   +A      GL  GIPG     G PG          
Sbjct: 497 GLPGLPG-PPGSLGFPGQKGEK--GQAGATGPKGL-PGIPGAPGAPGFPGSKGEPGDILT 552

Query: 533 ----------LGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGG 582
                     LG   G PGL    G PG   +PG L   K    G    G  G  G  G 
Sbjct: 553 FPGMKGDKGELG-SPGAPGLPGLPGTPGQDGLPG-LPGPKGEPGGITFKGERGPPGNPGL 610

Query: 583 VGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAA 642
            G+PG +   GP                G VG  G+ G+  G  G PG+ G  G P    
Sbjct: 611 PGLPGNIGPMGPPGFGPP----------GPVGEKGIQGV-AGNPGQPGIPGPKGDPGQTI 659

Query: 643 AKAAKYGVAARPG 655
            +  K G+   PG
Sbjct: 660 TQPGKPGLPGNPG 672



 Score =  114 bits (284), Expect = 4e-25
 Identities = 144/431 (33%), Positives = 167/431 (38%), Gaps = 54/431 (12%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPG-------GLAGAGLGAGLGAFPAV 75
            P    G PG  P GVPG    P L PG K  K  PG       GL G     GL  +P  
Sbjct: 1037 PQGVEGPPG--PSGVPGQPGSPGL-PGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGN 1093

Query: 76   TFPGALVPGGVADAAA----AYKAAKAGAGLGGVPGVGGLGVSAGAVVP--QPGAGVKPG 129
              PG  + G V D           AK   GL G PG  G     G   P   PG   +PG
Sbjct: 1094 --PG--IKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEPG 1149

Query: 130  KVPGVGLPGVYPGGVLPGARF-PGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGP 188
             V G G PG  PG   PG +  PG   +PG P G   +P  PG G    G PG+    G 
Sbjct: 1150 PVGGGGHPG-QPGP--PGEKGKPGQDGIPG-PAGQKGEPGQPGFGNP--GPPGLPGLSGQ 1203

Query: 189  QPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAA 248
            +    L      P +PG  GLP   G+ P  +G  GV G  G  G P     GP+     
Sbjct: 1204 KGDGGL------PGIPGNPGLPGPKGE-PGFHGFPGVQGPPGPPGSPGPALEGPKGNPGP 1256

Query: 249  AAKAAAKFGAGAAGV--LPGVGGA----GVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAK 302
                      G  G   LPG GG     G PG PG +PG+ G+ G   P           
Sbjct: 1257 QGPPGRPGLPGPEGPPGLPGNGGIKGEKGNPGQPG-LPGLPGLKGDQGPPGLQGNPGRPG 1315

Query: 303  AAKYGAAAGLVPGGPGFG--PGVVGVPGA----GVPG-VGVPGAGIPVVPGAGIPGAAVP 355
                    GL PG PGF    G  GVPG+    G PG +G PG   P +PG       + 
Sbjct: 1316 LNGMKGDPGL-PGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGP--PGLPGPSGQSIIIK 1372

Query: 356  GVVSPEAAAKAAAKAAKYGARPGVGVGGI--PTYGVGAGGFPGFGVGVGGIPGVAGVPGV 413
            G   P             G +   G+ G   P    G  G PGF  G GG  G  G+PG 
Sbjct: 1373 GDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFD-GAGGRKGDPGLPGQ 1431

Query: 414  GGVPGVGGVPG 424
             G  G+ G PG
Sbjct: 1432 PGTRGLDGPPG 1442


>gi|15890088 type IV collagen alpha 5 isoform 3 precursor [Homo
            sapiens]
          Length = 1688

 Score =  160 bits (405), Expect = 4e-39
 Identities = 217/706 (30%), Positives = 262/706 (37%), Gaps = 137/706 (19%)

Query: 23   PSRPG--GVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAG-------------LGA 67
            P  PG  G PG     +P        GP G P  P   GL G               +G 
Sbjct: 428  PGAPGLPGPPGPAGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGT 487

Query: 68   GLGAFPAVT-FPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGV 126
            G+   P     PG   P G        K  K  AG  G  G+ G+          PGA  
Sbjct: 488  GISGPPGQPGLPGLPGPPGSL-GFPGQKGEKGQAGATGPKGLPGI----------PGAPG 536

Query: 127  KPGKVPGVGLPG---VYPG-----GVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAG 178
             PG     G PG    +PG     G L     PG+  LPG P   G+ P  PG  G   G
Sbjct: 537  APGFPGSKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGL-PGLPGPKGEPGG 595

Query: 179  IPGVGPFGGP-QPGVPLGYPIK-APKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPT 236
            I   G  G P  PG+P G P    P  P G+G P   G+     G  GVAG  G+ G P 
Sbjct: 596  ITFKGERGPPGNPGLP-GLPGNIGPMGPPGFGPPGPVGEK----GIQGVAGNPGQPGIPG 650

Query: 237  GTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGG------IAGVGT 290
              G  P        K       G  G +   G  G+PG PG +PGI G      I G+G 
Sbjct: 651  PKG-DPGQTITQPGKPGLPGNPGRDGDVGLPGDPGLPGQPG-LPGIPGSKGEPGIPGIGL 708

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA-GVPG-VGVPGA-GIPVVPGA 347
            P                      PG  GF PG+ G PGA G PG +G+ G  G P  PG 
Sbjct: 709  PGP--------------------PGPKGF-PGIPGPPGAPGTPGRIGLEGPPGPPGFPGP 747

Query: 348  -GIPGAAVPGVVSPEAAAKAAAKAAKYGAR--------PG-VGVGGIP--TYGVGAGGFP 395
             G PG A+PG   P             G R        PG  G+ G+P     VG  G P
Sbjct: 748  KGEPGFALPGPPGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGDVGPNGQP 807

Query: 396  GF-------GVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGV 448
            G        G+GV G PG  G+PG  G PG+ G+PG    P                PG+
Sbjct: 808  GPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLDVPGPPGERGSPGI 867

Query: 449  GVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAK 508
              APG    PG   +PG+    G    PG     G+   PG  PG +    +S       
Sbjct: 868  PGAPGPIGPPG---SPGLPGKAGASGFPGTKGEMGMMGPPG-PPGPLGIPGRS------- 916

Query: 509  AQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGA----LAAAKAA 564
                       G+PGL    G+ G     G  G     G PG    PG     L  +K  
Sbjct: 917  -----------GVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGE 965

Query: 565  KYGAAVPGVLGGLGALGGVGIPG-----GVVGAGPAAAAAAAKA-AAKAAQFGLVGAAGL 618
            K    +PG+ G  G  G  G+PG     G+ G          K       Q GL+G  GL
Sbjct: 966  KGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGL 1025

Query: 619  GGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
             G  +G +G PG  G+ G PP  +      GV  +PG   SP  PG
Sbjct: 1026 KGT-IGDMGFPGPQGVEG-PPGPS------GVPGQPG---SPGLPG 1060



 Score =  158 bits (400), Expect = 1e-38
 Identities = 209/673 (31%), Positives = 258/673 (38%), Gaps = 98/673 (14%)

Query: 18   LSILHPSRPGGVPGAI--PG--GVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFP 73
            + +  P  P G+PG I  PG  G+PG    P  GP G  +   PG     G+    G   
Sbjct: 818  IGVQGPPGPPGIPGPIGQPGLHGIPGEKGDP--GPPGLDVPGPPGERGSPGIPGAPGPIG 875

Query: 74   AVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGG-LGVSAGAVVP----------QP 122
                PG  +PG     A+ +   K   G+ G PG  G LG+   + VP          QP
Sbjct: 876  PPGSPG--LPGKAG--ASGFPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQP 931

Query: 123  GAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGG--AFAGIP 180
            G     G+    G PG+ PG   PG   P +    G     G+ P  PGV G   + G+P
Sbjct: 932  GLPGPTGEKGSKGEPGL-PGP--PGPMDPNLLGSKGEKGEPGL-PGIPGVSGPKGYQGLP 987

Query: 181  GVG--PFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGT 238
            G    P    QPG+P G P   PK  G  GLP   G +    GP G+ G  G  G+P   
Sbjct: 988  GDPGQPGLSGQPGLP-GPP--GPK--GNPGLPGQPGLI----GPPGLKGTIGDMGFPGPQ 1038

Query: 239  GV-GPQAAAAAAAKAAAKFGAGAAGVL--PGVGGAGVPGVPG--------AIPGIGGIAG 287
            GV GP   +    +  +    G  G    PG+   G+PG+PG          PG  GI G
Sbjct: 1039 GVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKG 1098

Query: 288  -VGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG----AGVPG-VGVPGAGI 341
             VG P             +        PG PGF PG  G PG    +G PG  G+PG   
Sbjct: 1099 SVGDPGLPGLPGTPGAKGQ--------PGLPGF-PGTPGPPGPKGISGPPGNPGLPGEPG 1149

Query: 342  PVVPGAGIPGAAVP----GVVSPEAAAKAAAKAAKYGARPGVGVGGIP-----TYGVGAG 392
            PV  G G PG   P    G    +     A +  + G +PG G  G P     +   G G
Sbjct: 1150 PV-GGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPG-QPGFGNPGPPGLPGLSGQKGDG 1207

Query: 393  GFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVP-GVGVA 451
            G PG   G  G+PG  G PG  G PGV G PG    P      A +  K    P G    
Sbjct: 1208 GLPGIP-GNPGLPGPKGEPGFHGFPGVQGPPG----PPGSPGPALEGPKGNPGPQGPPGR 1262

Query: 452  PGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGI----GPGGVAAAAKSAAKVAA 507
            PG    PG    PG+    G+    G    PG+   PG+    GP G+            
Sbjct: 1263 PGFQGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGM 1322

Query: 508  KAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYG 567
            K           G PGL    G PG+   +GVPG     G PG    PG       +   
Sbjct: 1323 K-----------GDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPGPSGQS 1371

Query: 568  AAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGG-LGVGGL 626
              + G  G  G  G  G+ G     GP              + GL G  G GG  G  GL
Sbjct: 1372 IIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGL 1431

Query: 627  -GVPGVGGLGGIP 638
             G PG  GL G P
Sbjct: 1432 PGQPGTRGLDGPP 1444



 Score =  131 bits (330), Expect = 2e-30
 Identities = 185/614 (30%), Positives = 227/614 (36%), Gaps = 129/614 (21%)

Query: 26   PGGVPGAIPGGVPGGVFYPAL----GPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGAL 81
            P G PG  P G+PG    P L    G  G+P  P P G  G+    GL        PG  
Sbjct: 903  PPGPPG--PLGIPGRSGVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGL--------PGP- 951

Query: 82   VPGGVADAAAAYKAAKAGAGLGGVPGVGG----LGVSAGAVVP----QPGAGVKPGKVPG 133
             PG +       K  K   GL G+PGV G     G+      P    QPG    PG    
Sbjct: 952  -PGPMDPNLLGSKGEKGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGN 1010

Query: 134  VGLPGVYPG--------GVLPGARFPGVGVLPGVPTGAGV--KPKAPGVGGAFA--GIPG 181
             GLPG  PG        G +    FPG   + G P  +GV  +P +PG+ G     G PG
Sbjct: 1011 PGLPG-QPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDPG 1069

Query: 182  VGPFGGP-------QPGVPLGYP--------IKAPKLPGGYGLPYTTGK--------LPY 218
            +   G P       +PG+P GYP        +  P LPG  G P   G+         P 
Sbjct: 1070 ISSIGLPGLPGPKGEPGLP-GYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPG 1128

Query: 219  GYGPGGVAGAAGKAGYPTGTGV----------GPQAAAAAAAKAAAKFGAGAAGVLPGVG 268
              GP G++G  G  G P   G           GP        +      AG  G  PG  
Sbjct: 1129 PPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGE-PGQP 1187

Query: 269  GAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGL--VPGGPGFGPGVVGV 326
            G G PG PG +PG+ G  G G                     GL  +PG PG  PG  G 
Sbjct: 1188 GFGNPGPPG-LPGLSGQKGDG---------------------GLPGIPGNPGL-PGPKGE 1224

Query: 327  PGA-GVPGV----GVPGAGIPVVPGA-GIPGAAVP-------GVVSPEAAAKAAAKAAKY 373
            PG  G PGV    G PG+  P + G  G PG   P       G+  PE            
Sbjct: 1225 PGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGFQGLPGPEGPPGLPGNGGIK 1284

Query: 374  GARPGVGVGGIPTYG--VGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEA 431
            G +   G  G+P      G  G PG   G  G PG+ G+ G  G+PGV G PG+   P  
Sbjct: 1285 GEKGNPGQPGLPGLPGLKGDQGPPGLQ-GNPGRPGLNGMKGDPGLPGVPGFPGMK-GPSG 1342

Query: 432  QAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGI- 490
               +A    + GL+   G  PG+    G  +     +  G    PG+   PG+   PG  
Sbjct: 1343 VPGSAGPEGEPGLIGPPG-PPGLPGPSGQSI-----IIKGDAGPPGIPGQPGLKGLPGPQ 1396

Query: 491  GPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPG 550
            GP G+                    GL  G  G G   G PGL    G  GL    G  G
Sbjct: 1397 GPQGLPGPTGPPGDPGRN-------GL-PGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDG 1448

Query: 551  FGAVPGALAAAKAA 564
                PG    +  A
Sbjct: 1449 LQGPPGPPGTSSVA 1462



 Score =  130 bits (327), Expect = 4e-30
 Identities = 205/733 (27%), Positives = 258/733 (35%), Gaps = 141/733 (19%)

Query: 1   MAGLTAAAPRPGVLLLLLSIL-HPSRPGGVPGAIPG---------GVPGGVFYPAL-GPG 49
           + G++ AA   G+ LL LS+   P+      G  PG         G  G   +P L G  
Sbjct: 3   LRGVSLAA---GLFLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHP 59

Query: 50  GKPLKPVPGGLAGAGLGAGLGAFPAVTFP-GALVPGGVADAAAAYKAAKAGAGLGGVPGV 108
           G P  P P G  G     G    P    P G   P G+              G  G PG+
Sbjct: 60  GLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLP-------------GFPGTPGL 106

Query: 109 GGLGVSAGAVVPQ--PGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVK 166
            G+    GA  PQ  PG     G+    G PG +PG   P    PG+  + G P G+ + 
Sbjct: 107 PGMPGHDGAPGPQGIPGCNGTKGERGFPGSPG-FPGLQGPPGP-PGIPGMKGEP-GSIIM 163

Query: 167 PKAPGVGG--AFAGIPGV----GPFGGPQPGVPLGYP-IKAPKLPGGYGLPYTTGKLPYG 219
              PG  G   + G PG+    GP G P P  P G P +  P  PG  GLP   G +   
Sbjct: 164 SSLPGPKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGP--PGPPGLPGPKGNMGLN 221

Query: 220 Y-GPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAA-AKFGAGAAGVLPGVGGAGVPGVPG 277
           + GP G  G  G  G P     GP    +   +    +F  G  G+    G  G PG+ G
Sbjct: 222 FQGPKGEKGEQGLQGPP-----GPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRG 276

Query: 278 AIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA------- 329
                GG  G  G            K  + G     +PG PG  PG  G PG        
Sbjct: 277 PPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPG--IPGLPG-DPGYPGEPGRDGEKGQK 333

Query: 330 ------GVPGVGVPGAGIPVVPGA-------GIPGA----AVPGVVSPEAAAKAAAKAAK 372
                 G PG+ +P  G  +  G        G+PG       PG+  P            
Sbjct: 334 GDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLP-------- 385

Query: 373 YGARPGVGVGGIPTYGVGAGGFPGF----------GVGVGGIPGVAGVPGVGGVPGVGGV 422
               PG  V G P    G  GFPG           G+ + G PG+ G PG  G+PG  G 
Sbjct: 386 --GPPGAAVMGPP----GPPGFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGP 439

Query: 423 PGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAP 482
            G  I P  +          G     G+    GV    G      +  G+   PG    P
Sbjct: 440 AGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPG---QP 496

Query: 483 GVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPG---------- 532
           G+   PG  PG +    +   K   +A      GL  GIPG     G PG          
Sbjct: 497 GLPGLPG-PPGSLGFPGQKGEK--GQAGATGPKGL-PGIPGAPGAPGFPGSKGEPGDILT 552

Query: 533 ----------LGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGG 582
                     LG   G PGL    G PG   +PG L   K    G    G  G  G  G 
Sbjct: 553 FPGMKGDKGELG-SPGAPGLPGLPGTPGQDGLPG-LPGPKGEPGGITFKGERGPPGNPGL 610

Query: 583 VGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAA 642
            G+PG +   GP                G VG  G+ G+  G  G PG+ G  G P    
Sbjct: 611 PGLPGNIGPMGPPGFGPP----------GPVGEKGIQGV-AGNPGQPGIPGPKGDPGQTI 659

Query: 643 AKAAKYGVAARPG 655
            +  K G+   PG
Sbjct: 660 TQPGKPGLPGNPG 672



 Score =  114 bits (286), Expect = 2e-25
 Identities = 148/432 (34%), Positives = 169/432 (39%), Gaps = 53/432 (12%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPG-------GLAGAGLGAGLGAFPAV 75
            P    G PG  P GVPG    P L PG K  K  PG       GL G     GL  +P  
Sbjct: 1037 PQGVEGPPG--PSGVPGQPGSPGL-PGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGN 1093

Query: 76   TFPGALVPGGVADAAA----AYKAAKAGAGLGGVPGVGGLGVSAGAVVP--QPGAGVKPG 129
              PG  + G V D           AK   GL G PG  G     G   P   PG   +PG
Sbjct: 1094 --PG--IKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEPG 1149

Query: 130  KVPGVGLPGVYPGGVLPGARF-PGVGVLPGVPTGAGVKPKAPGVGGAFA-GIPGV-GPFG 186
             V G G PG  PG   PG +  PG   +PG P G   +P  PG G     G+PG+ G  G
Sbjct: 1150 PVGGGGHPG-QPGP--PGEKGKPGQDGIPG-PAGQKGEPGQPGFGNPGPPGLPGLSGQKG 1205

Query: 187  -GPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAA 245
             G  PG+P       P LPG  G P   G  P   GP G  G+ G A        GPQ  
Sbjct: 1206 DGGLPGIPGN-----PGLPGPKGEPGFHG-FPGVQGPPGPPGSPGPALEGPKGNPGPQGP 1259

Query: 246  AAAAAKAAAKFGAGAAGVLPGVGGA----GVPGVPGAIPGIGGIAGVGTPAAAAAAAAAA 301
                         G  G LPG GG     G PG PG +PG+ G+ G   P          
Sbjct: 1260 PGRPGFQGLPGPEGPPG-LPGNGGIKGEKGNPGQPG-LPGLPGLKGDQGPPGLQGNPGRP 1317

Query: 302  KAAKYGAAAGLVPGGPGFG--PGVVGVPGA----GVPG-VGVPGAGIPVVPGAGIPGAAV 354
                     GL PG PGF    G  GVPG+    G PG +G PG   P +PG       +
Sbjct: 1318 GLNGMKGDPGL-PGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGP--PGLPGPSGQSIII 1374

Query: 355  PGVVSPEAAAKAAAKAAKYGARPGVGVGGI--PTYGVGAGGFPGFGVGVGGIPGVAGVPG 412
             G   P             G +   G+ G   P    G  G PGF  G GG  G  G+PG
Sbjct: 1375 KGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFD-GAGGRKGDPGLPG 1433

Query: 413  VGGVPGVGGVPG 424
              G  G+ G PG
Sbjct: 1434 QPGTRGLDGPPG 1445


>gi|116256354 alpha 2 type IV collagen preproprotein [Homo sapiens]
          Length = 1712

 Score =  160 bits (405), Expect = 4e-39
 Identities = 221/710 (31%), Positives = 280/710 (39%), Gaps = 107/710 (15%)

Query: 18   LSILHPSRPGGVPGAI-PGGVPGGVFYPAL-----GPGGKPLKPVPGGLAGA-------- 63
            LSI    +  G+PG + P G  G    PAL     GP GK   P P GL G         
Sbjct: 391  LSIGDGDQRRGLPGEMGPKGFIGDPGIPALYGGPPGPDGKRGPPGPPGLPGPPGPDGFLF 450

Query: 64   GL--GAGLGAFPAVT-FPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVP 120
            GL    G   FP +   PGA  P G    A   +  +    + G+PG+ G    AG +  
Sbjct: 451  GLKGAKGRAGFPGLPGSPGARGPKGWKGDAGECRCTEGDEAIKGLPGLPGPKGFAG-ING 509

Query: 121  QPGAGVKPGKVPGVGLPGV-----YPGGV-LPGAR----------FPGVGVLPGVPTGAG 164
            +PG     G     GLPG       PG +  PG +            G    PGVP   G
Sbjct: 510  EPGRKGDRGDPGQHGLPGFPGLKGVPGNIGAPGPKGAKGDSRTITTKGERGQPGVPGVPG 569

Query: 165  VKPK--APGVGG--AFAGIPGV------GPFGGP-QPGVPLGYPIKAPKLPGGYGLPYTT 213
            +K    +PG  G   F G+PG       GP G P  PG+P          P G GLP   
Sbjct: 570  MKGDDGSPGRDGLDGFPGLPGPPGDGIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLK 629

Query: 214  GKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPG-VGGA-G 271
            G+  +  G  G+ G  G  G P   G   Q       K A   G     + PG +GG  G
Sbjct: 630  GQRGFP-GDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKRAVG-GDRQEAIQPGCIGGPKG 687

Query: 272  VPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGL-VPGGPGF-GP----GVV 324
            +PG+PG  PG  G  G+ G P  A A          G A     PG PGF GP    G V
Sbjct: 688  LPGLPGP-PGPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAV 746

Query: 325  GVPGA-GVPG-VGVPGAGIPVVPGA-GIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGV 381
            G+PG  G PG +G+PG   P  PG  G+PG  +     P   A         G     G+
Sbjct: 747  GLPGPDGSPGPIGLPGPDGP--PGERGLPGEVLGAQPGPRGDA---------GVPGQPGL 795

Query: 382  GGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAK 441
             G+P    G  G PGF  G  G+PG+ G+ G  G+PG  G PG+                
Sbjct: 796  KGLP----GDRGPPGFR-GSQGMPGMPGLKGQPGLPGPSGQPGL---------------- 834

Query: 442  YGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG-IGPGGVAAAAK 500
            YG  PG+   PG   APG     G+   PG    PG    PG   APG +G  G++    
Sbjct: 835  YG-PPGLHGFPG---APGQEGPLGLPGIPGREGLPGDRGDPGDTGAPGPVGMKGLSGDRG 890

Query: 501  SAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAA 560
             A     +    +      G  G+    G PGL    G PG+    G+PG    PG   +
Sbjct: 891  DAGFTGEQGHPGSP-----GFKGIDGMPGTPGLKGDRGSPGMDGFQGMPGLKGRPGFPGS 945

Query: 561  AKAAKYGAAVPGVLGGLGALGGVGIPG--GVVGAGPAAAAAAAKAAAKAAQFGLVGAAG- 617
               A +   +PG+ G  G  G  G  G  G  G  P           +    G +G  G 
Sbjct: 946  KGEAGF-FGIPGLKGLAGEPGFKGSRGDPGPPGPPPVILPGMKDIKGEKGDEGPMGLKGY 1004

Query: 618  LGGLGVGGL-GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGA 666
            LG  G+ G+ G+PG+ G+ G+P          G    PG    P FPG A
Sbjct: 1005 LGAKGIQGMPGIPGLSGIPGLPGRPGHIKGVKGDIGVPGIPGLPGFPGVA 1054



 Score =  149 bits (376), Expect = 8e-36
 Identities = 217/765 (28%), Positives = 278/765 (36%), Gaps = 170/765 (22%)

Query: 28  GVPGAIPGGVPGGVFYPALGPGGKPLKP----------VPGGLAGAGLGA--GLGAFPAV 75
           G PG  P G+P    +P + P G    P             G+ G  L    G+  FP +
Sbjct: 246 GQPG--PNGIPSDTLHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGISLKGEEGIMGFPGL 303

Query: 76  T-FPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQ--PGAGVKPGKVP 132
             +PG     G    +   K ++   G  G  G  G    AG   P   P     P    
Sbjct: 304 RGYPGLSGEKG----SPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPPGLPAYSPHPSLAK 359

Query: 133 GV-GLPGVYPGGV-LPGAR----FPGVGVLPGVPTGAGVKPKA-PGVGG--AFAGIPGVG 183
           G  G PG +PG    PG++     PG+   PG+  G G + +  PG  G   F G PG+ 
Sbjct: 360 GARGDPG-FPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGLPGEMGPKGFIGDPGIP 418

Query: 184 PFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GP 242
              G  PG     P      PG  GLP   G   + +G  G  G AG  G P   G  GP
Sbjct: 419 ALYGGPPG-----PDGKRGPPGPPGLPGPPGPDGFLFGLKGAKGRAGFPGLPGSPGARGP 473

Query: 243 QAAAAAAAKAAAKFGAGAAGVLPGVGG----AGVPGVPG--------------AIPGIGG 284
           +     A +     G  A   LPG+ G    AG+ G PG                PG+ G
Sbjct: 474 KGWKGDAGECRCTEGDEAIKGLPGLPGPKGFAGINGEPGRKGDRGDPGQHGLPGFPGLKG 533

Query: 285 IAG-VGTPAAAAAAAAAAKAAKYGAAA--------------------GL-----VPGGPG 318
           + G +G P    A   +      G                       GL     +PG PG
Sbjct: 534 VPGNIGAPGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDGSPGRDGLDGFPGLPGPPG 593

Query: 319 FG-------PGVVGVPGA-------GVPGVGVPG----------AGIPVVPG-AGIPG-A 352
            G       PG  G+PG        G PG+G+PG          AG+P  PG  G PG A
Sbjct: 594 DGIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFPGDAGLPGPPGFLGPPGPA 653

Query: 353 AVPGVVSPEAAAKAAAKAAKYGA-RPGV-----GVGGI-----PTYGVGAGGFPGFGVGV 401
             PG +  +   K A    +  A +PG      G+ G+     PT   G  G PGF  G 
Sbjct: 654 GTPGQIDCDTDVKRAVGGDRQEAIQPGCIGGPKGLPGLPGPPGPTGAKGLRGIPGF-AGA 712

Query: 402 GGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVG 461
            G PG  G+PG  G  G  G PG  I P     A       G    +G+ PG    PG  
Sbjct: 713 DGGPGPRGLPGDAGREGFPGPPGF-IGPRGSKGAVGLPGPDGSPGPIGL-PGPDGPPGER 770

Query: 462 VAPG--VGLAPGVGVAPGVGVAPGVGVAPG-IGPGGVAAAAKSAAKVAAKAQLRAAAGLG 518
             PG  +G  PG     GV   PG+   PG  GP G                 R + G+ 
Sbjct: 771 GLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPPG----------------FRGSQGM- 813

Query: 519 AGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLG 578
            G+PGL    G PGL   +G PGL    G+ GF   PG        +    +PG+ G  G
Sbjct: 814 PGMPGL---KGQPGLPGPSGQPGLYGPPGLHGFPGAPG-------QEGPLGLPGIPGREG 863

Query: 579 ALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL-GVGGL----------G 627
             G  G PG     GP      +     A   G  G  G  G  G+ G+          G
Sbjct: 864 LPGDRGDPGDTGAPGPVGMKGLSGDRGDAGFTGEQGHPGSPGFKGIDGMPGTPGLKGDRG 923

Query: 628 VPGVGGLGGIP--------PAAAAKAAKYGVAARPGFGLSPIFPG 664
            PG+ G  G+P        P +  +A  +G+    G    P F G
Sbjct: 924 SPGMDGFQGMPGLKGRPGFPGSKGEAGFFGIPGLKGLAGEPGFKG 968



 Score =  142 bits (359), Expect = 8e-34
 Identities = 196/634 (30%), Positives = 247/634 (38%), Gaps = 87/634 (13%)

Query: 48   PGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGAL-------VPGGVADAAAAYKAAKAG- 99
            PG   LK VPG +   G     G    +T  G         VPG   D  +  +    G 
Sbjct: 526  PGFPGLKGVPGNIGAPGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDGSPGRDGLDGF 585

Query: 100  AGLGGVPGVGGLGVSAGAVVPQ-PGAGVKPGKV--PGVGLPGVYPGGVLPGAR-FPGVGV 155
             GL G PG G  G       P  PG    PG++  PG+GLPG      L G R FPG   
Sbjct: 586  PGLPGPPGDGIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPG------LKGQRGFPGDAG 639

Query: 156  LPGVPTGAGVKPKA--PG-----------VGGAFAGIPGVGPFGGPQ--PGVPLGYPIKA 200
            LPG P   G    A  PG           VGG        G  GGP+  PG+P   P   
Sbjct: 640  LPGPPGFLGPPGPAGTPGQIDCDTDVKRAVGGDRQEAIQPGCIGGPKGLPGLP--GPPGP 697

Query: 201  PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTG-VGPQAAAAAAAKAAAKFGAG 259
                G  G+P   G    G GP G+ G AG+ G+P   G +GP+ +  A          G
Sbjct: 698  TGAKGLRGIPGFAGA-DGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVGLPGPDGSPG 756

Query: 260  AAGVLPGVGGA----GVPG-VPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLV 313
              G LPG  G     G+PG V GA PG  G AGV G P               G+    +
Sbjct: 757  PIG-LPGPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPPGFRGSQG--M 813

Query: 314  PGGPGFGPGVVGVPG-AGVPGV-GVPGA-GIPVVPGAGIPGAAVPGVVSPEAAAKAAAKA 370
            PG PG   G  G+PG +G PG+ G PG  G P  PG   P   +PG+   E         
Sbjct: 814  PGMPGL-KGQPGLPGPSGQPGLYGPPGLHGFPGAPGQEGP-LGLPGIPGREGLPGDRGDP 871

Query: 371  AKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPE 430
               GA   VG+ G+     G  G  GF  G  G PG  G  G+ G+PG  G+ G   SP 
Sbjct: 872  GDTGAPGPVGMKGLS----GDRGDAGF-TGEQGHPGSPGFKGIDGMPGTPGLKGDRGSPG 926

Query: 431  AQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGI 490
                          +PG+   PG   + G     G+    G+   PG   + G    PG 
Sbjct: 927  MDGFQG--------MPGLKGRPGFPGSKGEAGFFGIPGLKGLAGEPGFKGSRGDPGPPGP 978

Query: 491  GPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPG 550
             P            +     ++   G   G  GL   +G  G+    G+PGL   +G+PG
Sbjct: 979  PP----------VILPGMKDIKGEKG-DEGPMGLKGYLGAKGIQGMPGIPGL---SGIPG 1024

Query: 551  FGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQF 610
                PG +   K  K    VPG+ G  G  G  G PG     G   +     A  +A  +
Sbjct: 1025 LPGRPGHI---KGVKGDIGVPGIPGLPGFPGVAGPPGITGFPGFIGSRGDKGAPGRAGLY 1081

Query: 611  GLVGAAG-LGGLG-----VGGLGVPGVGGLGGIP 638
            G +GA G  G +G      G  G+ G  G  GIP
Sbjct: 1082 GEIGATGDFGDIGDTINLPGRPGLKGERGTTGIP 1115



 Score =  132 bits (333), Expect = 8e-31
 Identities = 217/770 (28%), Positives = 272/770 (35%), Gaps = 169/770 (21%)

Query: 28   GVPGAIPGGVPGGVFYPALGPGGKP-LKPVPGGLAGAGLG----AGLGAFPAVT-FPGAL 81
            G+PG  P G PG +  P  GP G P  + +PG + GA  G    AG+   P +   PG  
Sbjct: 747  GLPG--PDGSPGPIGLP--GPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDR 802

Query: 82   VPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQ-----PGAGVKPGKVPGVGL 136
             P G   +    +      GL G PG+ G     G   P      PGA   PG+   +GL
Sbjct: 803  GPPGFRGS----QGMPGMPGLKGQPGLPGPSGQPGLYGPPGLHGFPGA---PGQEGPLGL 855

Query: 137  PGVYPGGVLPGARF-PGVGVLPGVP--------------TGAGVKPKAPGVGGAFAGIPG 181
            PG+     LPG R  PG    PG                TG    P +PG  G   G+PG
Sbjct: 856  PGIPGREGLPGDRGDPGDTGAPGPVGMKGLSGDRGDAGFTGEQGHPGSPGFKG-IDGMPG 914

Query: 182  VGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTG-- 239
                 G +    +      P L G  G P + G+  + +G  G+ G AG+ G+    G  
Sbjct: 915  TPGLKGDRGSPGMDGFQGMPGLKGRPGFPGSKGEAGF-FGIPGLKGLAGEPGFKGSRGDP 973

Query: 240  --VGPQAAAAAAAK-----------AAAKFGAGAAGV--LPGVGG-AGVPGVPG------ 277
               GP        K              K   GA G+  +PG+ G +G+PG+PG      
Sbjct: 974  GPPGPPPVILPGMKDIKGEKGDEGPMGLKGYLGAKGIQGMPGIPGLSGIPGLPGRPGHIK 1033

Query: 278  ---------AIPGIGGIAGVGTPAAAAA----------AAAAAKAAKYGAAAGL------ 312
                      IPG+ G  GV  P                 A  +A  YG           
Sbjct: 1034 GVKGDIGVPGIPGLPGFPGVAGPPGITGFPGFIGSRGDKGAPGRAGLYGEIGATGDFGDI 1093

Query: 313  -----VPGGPGFGP--GVVGVPGA-------GVPG-VGVPG-AGIPVVPGA-GIPG-AAV 354
                 +PG PG     G  G+PG        G  G +G PG  G+  V G  G+ G    
Sbjct: 1094 GDTINLPGRPGLKGERGTTGIPGLKGFFGEKGTEGDIGFPGITGVTGVQGPPGLKGQTGF 1153

Query: 355  PGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGF-GV-GVGGIPGVAGVPG 412
            PG+  P  +     +    G +   G  G P    G  GFPG  G+ G+ G+PG  G PG
Sbjct: 1154 PGLTGPPGSQGELGRIGLPGGKGDDGWPGAP----GLPGFPGLRGIRGLHGLPGTKGFPG 1209

Query: 413  -----VGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVG 467
                 + G PG  G PG    P             G     G APG    PG   +PG+ 
Sbjct: 1210 SPGSDIHGDPGFPGPPGERGDPGEANTLPGPVGVPGQKGDQG-APGERGPPG---SPGLQ 1265

Query: 468  LAPGVGVAPGVGVAPGVGVAPGI----------GPGGVAAAAKSAAKVAAKAQLRAAAGL 517
              PG+     +  APG   APGI          GP G AA   S                
Sbjct: 1266 GFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTK 1325

Query: 518  G-------------AGIPGLGVGVGVPGLGVGAGVPGLGVG-------AGVPGFGAVPGA 557
            G              G+PG     G  G     G  G  VG        G PGF   PG 
Sbjct: 1326 GWAGDSGPQGRPGVFGLPGEKGPRGEQGFMGNTGPTG-AVGDRGPKGPKGDPGFPGAPGT 1384

Query: 558  LAAAKAAKYG---AAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVG 614
            + A   A      A  PG +G  G  G  G PG +   GP        A  KA      G
Sbjct: 1385 VGAPGIAGIPQKIAVQPGTVGPQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKA------G 1438

Query: 615  AAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
              G GG+      VPG  G  G P        + G   RPG   SP  PG
Sbjct: 1439 PQGRGGVS----AVPGFRGDEG-PIGHQGPIGQEGAPGRPG---SPGLPG 1480



 Score =  118 bits (296), Expect = 2e-26
 Identities = 211/720 (29%), Positives = 260/720 (36%), Gaps = 133/720 (18%)

Query: 43  YPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGL 102
           YP  G  G+P    P G  G     GL  FP +                  +  K   G 
Sbjct: 54  YPEKGGRGQPGPVGPQGYNGP---PGLQGFPGL------------------QGRKGDKGE 92

Query: 103 GGVPGVGGLGVSAGA--VVPQPGAGVKPGKVPGVGLPGVYPG--------GVLPGARFPG 152
            G PGV G     GA  V   PGA   PG  PG G P   PG        G       PG
Sbjct: 93  RGAPGVTGPKGDVGARGVSGFPGADGIPGH-PGQGGPRGRPGYDGCNGTQGDSGPQGPPG 151

Query: 153 VGVLPGVPTGAGVKPKAPGVGGAFA-------------GIPGVGPFGGPQPGVPLGY--- 196
                G P   G K +    G  +A             G PG+  F GP PG P G+   
Sbjct: 152 SEGFTGPPGPQGPKGQK---GEPYALPKEERDRYRGEPGEPGLVGFQGP-PGRP-GHVGQ 206

Query: 197 --PIKAPKLPGGYGLPYTTGKLPY-GYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAA 253
             P+ AP  PG  G P   G+    G G  GV G  G  G P   G+         A   
Sbjct: 207 MGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVKGEKGDVGQPGPNGIPSDTLHPIIAPTG 266

Query: 254 AKF------GAGAAGVLPGVGGAGVPGVPGAI--PGIGGIAGV----GTPAAAAAAAA-- 299
             F      G   +   PG+ G  + G  G +  PG+ G  G+    G+P    +     
Sbjct: 267 VTFHPDQYKGEKGSEGEPGIRGISLKGEEGIMGFPGLRGYPGLSGEKGSPGQKGSRGLDG 326

Query: 300 -----AAKAAKYGAAAGLVPGGPGFGP---------GVVGVPGA-GVPGV-GVPG-AGIP 342
                  +  K  A     PG P + P         G  G PGA G PG  G PG  G+P
Sbjct: 327 YQGPDGPRGPKGEAGDPGPPGLPAYSPHPSLAKGARGDPGFPGAQGEPGSQGEPGDPGLP 386

Query: 343 VVPGAGIPGA----AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFG 398
             PG  I        +PG + P+         A YG  PG      P    G  G PG  
Sbjct: 387 GPPGLSIGDGDQRRGLPGEMGPKGFIGDPGIPALYGGPPGPDGKRGPPGPPGLPGPPGPD 446

Query: 399 VGVGGIPGVAGVPGVGGVPGVGGVPG----VGISPEAQAAAAAKAAKYGLVPGVGVAPGV 454
             + G+ G  G  G  G+PG  G  G     G + E +     +A K GL PG+   PG 
Sbjct: 447 GFLFGLKGAKGRAGFPGLPGSPGARGPKGWKGDAGECRCTEGDEAIK-GL-PGL---PGP 501

Query: 455 GVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG-IGPGGVAAAAKSAAKVAAKAQLRA 513
               G+   PG     G     G+   PG+   PG IG  G   A   +  +  K + R 
Sbjct: 502 KGFAGINGEPGRKGDRGDPGQHGLPGFPGLKGVPGNIGAPGPKGAKGDSRTITTKGE-RG 560

Query: 514 AAGLGAGIPGLGVGVGVPGLGVGAGVPGL----GVG----AGVPGFGAVPGALAA-AKAA 564
             G+  G+PG+    G PG     G PGL    G G     G PG+  +PG      +  
Sbjct: 561 QPGV-PGVPGMKGDDGSPGRDGLDGFPGLPGPPGDGIKGPPGDPGYPGIPGTKGTPGEMG 619

Query: 565 KYGAAVPGVLGGLGALGGVGIPG--GVVG-AGPAAA-----------AAAAKAAAKAAQF 610
             G  +PG+ G  G  G  G+PG  G +G  GPA              A      +A Q 
Sbjct: 620 PPGLGLPGLKGQRGFPGDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKRAVGGDRQEAIQP 679

Query: 611 GLVGA-AGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAK-----YGVAARPGFGLSPIFPG 664
           G +G   GL GL  G  G  G  GL GIP  A A          G A R GF   P F G
Sbjct: 680 GCIGGPKGLPGL-PGPPGPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIG 738



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 142/479 (29%), Positives = 174/479 (36%), Gaps = 90/479 (18%)

Query: 23   PSRPGGVPGA-----IPGGVPGGVFYPALG--PGGKPLKPVPGGLAGAGLGAGLGAFPAV 75
            P RPG + G      +PG +PG   +P +   PG        G     G     G +  +
Sbjct: 1026 PGRPGHIKGVKGDIGVPG-IPGLPGFPGVAGPPGITGFPGFIGSRGDKGAPGRAGLYGEI 1084

Query: 76   TFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAV--VPQPG----AGVK-- 127
               G     G           K   G  G+PG+ G     G    +  PG     GV+  
Sbjct: 1085 GATGDFGDIGDTINLPGRPGLKGERGTTGIPGLKGFFGEKGTEGDIGFPGITGVTGVQGP 1144

Query: 128  PGKVPGVGLPGVY--PGGV-------LPGAR----FPGVGVLPGVPTGAGVKPK--APGV 172
            PG     G PG+   PG         LPG +    +PG   LPG P   G++     PG 
Sbjct: 1145 PGLKGQTGFPGLTGPPGSQGELGRIGLPGGKGDDGWPGAPGLPGFPGLRGIRGLHGLPGT 1204

Query: 173  GGAFAGIPGVGPFGGPQ-PGVP--LGYPIKAPKLPGGYGLPYTTGK--LPYGYGPGG--- 224
             G F G PG    G P  PG P   G P +A  LPG  G+P   G    P   GP G   
Sbjct: 1205 KG-FPGSPGSDIHGDPGFPGPPGERGDPGEANTLPGPVGVPGQKGDQGAPGERGPPGSPG 1263

Query: 225  ------------VAGAAGKAGYPTGTGV----GPQAAAAAAAKAAAKFGAGAAGV--LPG 266
                        ++GA G  G P   G+    GP     +AA   +K   G  G    PG
Sbjct: 1264 LQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPG 1323

Query: 267  VGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGV 326
              G      P   PG+ G+ G   P               GA     P GP   PG  G 
Sbjct: 1324 TKGWAGDSGPQGRPGVFGLPGEKGPRGEQGFMG--NTGPTGAVGDRGPKGPKGDPGFPGA 1381

Query: 327  PGAGVPGVGVPG-AGIP----VVPGA-------GIPGAAVPGVVSPEAAAKAAAKAAKYG 374
            PG     VG PG AGIP    V PG        G PGA  PG + P+          + G
Sbjct: 1382 PGT----VGAPGIAGIPQKIAVQPGTVGPQGRRGPPGA--PGEMGPQGPP------GEPG 1429

Query: 375  ARPGVGVGGIPTYGVGAGGFPGFG-----VGVGGIPGVAGVPGVGGVPGVGGVPGVGIS 428
             R   G  G    G G    PGF      +G  G  G  G PG  G PG+ G+PG  +S
Sbjct: 1430 FRGAPGKAGPQGRG-GVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVS 1487



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 93/301 (30%), Positives = 108/301 (35%), Gaps = 73/301 (24%)

Query: 23   PSRPG--GVPG---AIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTF 77
            P  PG  G PG    +PG  P GV      PG K  +  PG     G   GL  FP +T 
Sbjct: 1222 PGPPGERGDPGEANTLPG--PVGV------PGQKGDQGAPGERGPPG-SPGLQGFPGIT- 1271

Query: 78   PGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLP 137
            P + + G   D               G PG+ GL    G   P PG+   PG     G P
Sbjct: 1272 PPSNISGAPGDK--------------GAPGIFGLKGYRGPPGP-PGSAALPGSKGDTGNP 1316

Query: 138  GV--------YPGGVLPGARFPGVGVLPGV--------------PTGA--GVKPKAPGVG 173
            G         + G   P  R PGV  LPG               PTGA     PK P   
Sbjct: 1317 GAPGTPGTKGWAGDSGPQGR-PGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGD 1375

Query: 174  GAFAGIPG-VGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKA 232
              F G PG VG      PG+  G P K    PG  G     G  P   G  G  G  G+ 
Sbjct: 1376 PGFPGAPGTVGA-----PGIA-GIPQKIAVQPGTVGPQGRRGP-PGAPGEMGPQGPPGEP 1428

Query: 233  GYPTGTG-VGPQAAAAAAAKAAAKFGAGAAGV--------LPG-VGGAGVPGVPGAIPGI 282
            G+    G  GPQ     +A    +   G  G          PG  G  G+PG+PG    I
Sbjct: 1429 GFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSI 1488

Query: 283  G 283
            G
Sbjct: 1489 G 1489


>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
           sapiens]
          Length = 1487

 Score =  157 bits (398), Expect = 2e-38
 Identities = 244/775 (31%), Positives = 275/775 (35%), Gaps = 200/775 (25%)

Query: 36  GVPGGVFYPALGPGGKPLKPVPGGLAG-------------AGLGAGLGAFPAVTFP-GAL 81
           G PG    P  GP G P  P P GL G             AG GA LG       P G  
Sbjct: 153 GEPGTPGNP--GPPGPPGPPGPPGLGGNFAAQMAGGFDEKAG-GAQLGVMQGPMGPMGPR 209

Query: 82  VPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVY- 140
            P G A A    +  +   G  G PGV G     G     PG   KPG     G PG   
Sbjct: 210 GPPGPAGAPGP-QGFQGNPGEPGEPGVSGPMGPRG----PPGPPGKPGDDGEAGKPGKAG 264

Query: 141 ---PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGA--FAGIPGV-------GPFGGP 188
              P G      FPG   LPGV    G     PG+ GA   AG PGV       G  G P
Sbjct: 265 ERGPPGPQGARGFPGTPGLPGVKGHRGY----PGLDGAKGEAGAPGVKGESGSPGENGSP 320

Query: 189 QPGVPLGYPIKAPKL--------------PGGYGLPYTTGKLPYGYGPG--GVAGAAGKA 232
            P  P G P +  +               PG  G P   G  P G GPG  G  GA G+A
Sbjct: 321 GPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVG--PAG-GPGFPGAPGAKGEA 377

Query: 233 GYPTGTGVGPQAAAAAAAKAAAKFGAGAAGV--------LPGV-GGAGVPGVPGA----- 278
           G PTG   GP+ A     +       G AG         +PG  G AG PG+ GA     
Sbjct: 378 G-PTGAR-GPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPG 435

Query: 279 ---------------------IPGIGGIAG----------VGTPAAAAAAAAAAKAAKYG 307
                                 PGI G  G           G   A   A    K    G
Sbjct: 436 PRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARG 495

Query: 308 AAAGLVPGGPGFGPGVVGVPG-AGVPG-------VGVPGA-------------GIPVVPG 346
              G+ P GP   PG  G PG  G PG        G PG              G P  PG
Sbjct: 496 EPGGVGPIGP---PGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPG 552

Query: 347 -AGIPGA----AVPGVVSPEAAAKAAAKAAKYGARPG----VGVGGIPTYGVGAGGFPGF 397
             G+PGA      PG   P+     +    + G RPG     G  G P    G  GFPG 
Sbjct: 553 EPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDG-RPGPPGPQGARGQP----GVMGFPG- 606

Query: 398 GVGVGGIPGVAGVPGVGGVPGVGGVPGV-----GISPEAQAAAAAKAAKYGLVPGVGVAP 452
             G  G PG AG  G+ G PG+ G+PG         P   A  A +  + G       AP
Sbjct: 607 PKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQG-------AP 659

Query: 453 GVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG-IGPGGVAAAAKSAAKVAAKAQL 511
           G     G+   PG    PG G  PG    PG   APG +GP G            A+  L
Sbjct: 660 GPSGFQGLPGPPG---PPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQG-L 715

Query: 512 RAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAA------- 564
           +   GL  G PG     G  G    AG PG     G PG   +PG   AA  A       
Sbjct: 716 QGPRGL-PGTPGTD---GPKGASGPAGPPG---AQGPPGLQGMPGERGAAGIAGPKGDRG 768

Query: 565 ----KYGAAVPGVLGGLGALGGVGIPG--------GVVG-AGPAAAAAAAKAAAKAAQFG 611
               K     PG  GG G  G +G PG        G VG  GPA +A A  A  +  + G
Sbjct: 769 DVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETG 828

Query: 612 LVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGA 666
             G AG  G   G  G PG  G  G       +A + G A  PG    P  P GA
Sbjct: 829 PPGPAGFAG-PPGADGQPGAKGEQG-------EAGQKGDAGAPG----PQGPSGA 871



 Score =  155 bits (392), Expect = 1e-37
 Identities = 213/679 (31%), Positives = 243/679 (35%), Gaps = 93/679 (13%)

Query: 28  GVPGAIPGGVPGGVFYP--ALGPGGKPLKPVPGGLAGAGLGAGLGAFP------------ 73
           G PGA     P G   P  A GP G+P  P   G AGA    G    P            
Sbjct: 369 GAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIA 428

Query: 74  -AVTFPGALVPGGVADAAAAY--KAAKAGAGLGGVPGVGGLGVSAGAVVPQ--PGAGVKP 128
            A  FPG   P G   A      K      G+ G  G  G     G   PQ  PG   + 
Sbjct: 429 GAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEE 488

Query: 129 GKVPGVGLP-GVYPGGVLPGAR-FPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFG 186
           GK    G P GV P G  PG R  PG    PG    AG K  APG  G  +G+ G     
Sbjct: 489 GKRGARGEPGGVGPIGP-PGERGAPGNRGFPGQDGLAGPK-GAPGERGP-SGLAGPKGAN 545

Query: 187 GPQPGVPLGYPIKAPKLPGGYGLPYTTGKL-PYG-YGPGGVAGAAGKAGYPTGTGVGPQA 244
           G  PG P       P LPG  GL    G   P G  GP G  G  G+ G P     GPQ 
Sbjct: 546 G-DPGRP-----GEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPP-----GPQG 594

Query: 245 AAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPG--AIPGIGGIAGVGTPAAAAAAAAAAK 302
           A             GA G     G  G+PG PG   +PG  G  G   P     A  A +
Sbjct: 595 ARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGP--PGPAGPAGE 652

Query: 303 AAKYGAAAGLVPGGPGFG--PGVVGVPGAGVPGVGVPGAGIPVVPGAGIPG-AAVPGVVS 359
             + GA     PG  GF   PG  G PG G    G PG         G+PG A  PG+V 
Sbjct: 653 RGEQGA-----PGPSGFQGLPGPPGPPGEG----GKPG-------DQGVPGEAGAPGLVG 696

Query: 360 PEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGV 419
           P        +    GA+   G  G+P  G      P    G  G PG  G PG+ G+PG 
Sbjct: 697 PRGERGFPGERGSPGAQGLQGPRGLP--GTPGTDGPKGASGPAGPPGAQGPPGLQGMPGE 754

Query: 420 GGVPGVG--------ISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPG 471
            G  G+         +  +    A  K    GL   +G  PG   A G     G    PG
Sbjct: 755 RGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIG-PPGPAGANGEKGEVG---PPG 810

Query: 472 VGVAPGVGVAPGV-GVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLG-AGIPGLGVGVG 529
              + G   APG  G     GP G A    +  +  AK +   A   G AG PG     G
Sbjct: 811 PAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSG 870

Query: 530 VPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGV 589
            PG     GV G     G  G    PGA             PG  G +G  G  G PG  
Sbjct: 871 APGPQGPTGVTG---PKGARGAQGPPGA----------TGFPGAAGRVGPPGSNGNPGPP 917

Query: 590 VGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLG--VGGLGVPGVGGLGGI--PPAAAAKA 645
              GP+       A   +   G  G  GL G     G  G PG  G  G   PP     A
Sbjct: 918 GPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLA 977

Query: 646 AKYGVAARPGFGLSPIFPG 664
            + G+   PG      FPG
Sbjct: 978 GQRGIVGLPGQRGERGFPG 996



 Score =  145 bits (367), Expect = 9e-35
 Identities = 223/677 (32%), Positives = 251/677 (37%), Gaps = 108/677 (15%)

Query: 26   PGGV-PGAIPG--GVPGGVFYPA----LGPGGKPLKPVPGGLAGA-GLGAGLGAFPAVTF 77
            PGGV P   PG  G PG   +P      GP G P +  P GLAG  G     G       
Sbjct: 497  PGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGL 556

Query: 78   PGAL-VPGGVADAAAAYKAAKAGA-GLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVG 135
            PGA  + G   DA    K   +GA G  G PG  G   + G    QPG    PG     G
Sbjct: 557  PGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARG----QPGVMGFPGPKGANG 612

Query: 136  LPGVYPGGVLPGARFPGVGVLPGVP--TGAGVKPKAPGVGGAFA--GIPGVGPFGGPQPG 191
             PG      LPGA  PG+  LPG    TGA   P   G  G     G PG   F G  PG
Sbjct: 613  EPGKAGEKGLPGA--PGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQG-LPG 669

Query: 192  VPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAA 250
             P G P +  K PG  G+P   G  P   GP G  G  G+ G P   G+ GP+       
Sbjct: 670  PP-GPPGEGGK-PGDQGVPGEAGA-PGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPG 726

Query: 251  KAAAKFGAGAAGVLPGVGGA----GVPGVPGAIPGIGGIAG-VGTPAAAAAAAAAAKAAK 305
                K  +G AG  PG  G     G+PG  GA  GI G  G  G         A  K   
Sbjct: 727  TDGPKGASGPAGP-PGAQGPPGLQGMPGERGA-AGIAGPKGDRGDVGEKGPEGAPGKDGG 784

Query: 306  YGAAAGLVPGGPGFG---------PGVVGVPGA-GVPG----VGVPG-AGIPVVPGA-GI 349
             G    + P GP            PG  G  GA G PG     G PG AG    PGA G 
Sbjct: 785  RGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQ 844

Query: 350  PG-------------AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPG 396
            PG             A  PG   P  A          G +   G  G P    GA GFPG
Sbjct: 845  PGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPP----GATGFPG 900

Query: 397  FGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGL-----VPGVGVA 451
               G  G PG  G PG  G PG  G  G        +    +A + GL      PG    
Sbjct: 901  -AAGRVGPPGSNGNPGPPGPPGPSGKDGPK-GARGDSGPPGRAGEPGLQGPAGPPGEKGE 958

Query: 452  PGVGVAPGVGVAPG-VGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQ 510
            PG     G    PG  GLA   G+  G+    G    PG+ PG      K  A  A+  +
Sbjct: 959  PGDDGPSGAEGPPGPQGLAGQRGIV-GLPGQRGERGFPGL-PGPSGEPGKQGAPGASGDR 1016

Query: 511  LRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAV 570
                     G PG    VG PGL   AG PG     G PG    PG   A       A V
Sbjct: 1017 ---------GPPG---PVGPPGLTGPAGEPG---REGSPGADGPPGRDGA-------AGV 1054

Query: 571  PGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAG-LGGLGV------ 623
             G  G  GA+G  G PG     GPA          +A   G +G +G  G  G+      
Sbjct: 1055 KGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGP 1114

Query: 624  ----GGLGVPGVGGLGG 636
                G  G PG  GL G
Sbjct: 1115 RGDKGEAGEPGERGLKG 1131



 Score =  142 bits (357), Expect = 1e-33
 Identities = 221/705 (31%), Positives = 256/705 (36%), Gaps = 120/705 (17%)

Query: 23   PSRPG--GVPGAI-----PGGV-PGGVFYPALGPG--GKPLKPVPGGLAGAGLGAGLGAF 72
            P RPG  G+PGA      PG   P G   P+  PG  G+P  P P G  G     G+  F
Sbjct: 548  PGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQ---PGVMGF 604

Query: 73   PAVT-------------FPGAL----VPGGVADAAAAYKAAKAGA----GLGGVPGVGGL 111
            P                 PGA     +PG   +  AA     AG     G  G PG  G 
Sbjct: 605  PGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGF 664

Query: 112  GVSAGAVVPQPGAGVKPGK--VPG-VGLPGV--------YPGGV-LPGAR-FPGVGVLPG 158
                G   P PG G KPG   VPG  G PG+        +PG    PGA+   G   LPG
Sbjct: 665  QGLPGPPGP-PGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPG 723

Query: 159  VPTGAGVKPKA-----PGVGG--AFAGIPG-------VGPFGGPQPGVPLGYPIKAPKLP 204
             P   G K  +     PG  G     G+PG        GP  G +  V    P  AP   
Sbjct: 724  TPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGP-KGDRGDVGEKGPEGAPGKD 782

Query: 205  GGYGLPYTTGKL-PYG-------YGPGGVAGAAGKAGYPTGTG-VGPQAAAAAAAKAAAK 255
            GG GL    G   P G        GP G AG+AG  G P   G  GP   A  A    A 
Sbjct: 783  GGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGAD 842

Query: 256  FGAGAAGVLPGVGGAGVPGVPG-----AIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAA 310
               GA G     G  G  G PG       PG  G  GV  P  A  A     A  +  AA
Sbjct: 843  GQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAA 902

Query: 311  GLV-PGGPGFGPGVVGVPGA----GVPGV----GVPG-AGIPVVPG-AGIPGA-AVPGVV 358
            G V P G    PG  G PG     G  G     G PG AG P + G AG PG    PG  
Sbjct: 903  GRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDD 962

Query: 359  SPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPG 418
             P  A          G R   G+ G+P    G  GFPG       +PG +G PG  G PG
Sbjct: 963  GPSGAEGPPGPQGLAGQR---GIVGLPGQR-GERGFPG-------LPGPSGEPGKQGAPG 1011

Query: 419  VGGVPGVG--ISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAP 476
              G  G    + P      A +  + G       +PG    PG   A GV    G   A 
Sbjct: 1012 ASGDRGPPGPVGPPGLTGPAGEPGREG-------SPGADGPPGRDGAAGVKGDRGETGAV 1064

Query: 477  GVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGA-GIPGLGVGVGVPGLGV 535
            G   APG   +PG  P G         +  A+  +  +   GA GI G     G  G   
Sbjct: 1065 GAPGAPGPPGSPG--PAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAG 1122

Query: 536  GAGVPGLGVGAGVPGFGAVPGAL-------AAAKAAKYGA-AVPGVLGGLGALGGVGIPG 587
              G  GL    G  G   +PG         A+  A   G    PG +G  G  G  GIPG
Sbjct: 1123 EPGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPG 1182

Query: 588  GVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVG 632
             +   GP   +     A      G  G  G  G G+      G+G
Sbjct: 1183 PIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLG 1227



 Score =  128 bits (321), Expect = 2e-29
 Identities = 185/577 (32%), Positives = 207/577 (35%), Gaps = 58/577 (10%)

Query: 94  KAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGV 153
           K A    G  G PG  G           PG    PG     GL G +   +  G      
Sbjct: 143 KGAPGPRGRDGEPGTPG----------NPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAG 192

Query: 154 GVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGP-----QPGV--PLGYPIKAPKLPGG 206
           G   GV  G  + P  P      AG PG   F G      +PGV  P+G P   P  PG 
Sbjct: 193 GAQLGVMQGP-MGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMG-PRGPPGPPGK 250

Query: 207 YGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGAGAAGVLP 265
            G     GK P   G  G  G  G  G+P   G+ G +          AK  AGA GV  
Sbjct: 251 PGDDGEAGK-PGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKG 309

Query: 266 GVGGAGVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVV 324
             G  G  G PG + G  G+ G  G    A AA A     + G A    P GP  GPG  
Sbjct: 310 ESGSPGENGSPGPM-GPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFP 368

Query: 325 GVPG----AGVPGV-GVPGAGIPVVPGAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGV 379
           G PG    AG  G  G  GA  P     G PG   PG   P  A+         GA+   
Sbjct: 369 GAPGAKGEAGPTGARGPEGAQGP----RGEPG--TPGSPGPAGASGNPGTDGIPGAKGSA 422

Query: 380 GVGGIPTYGVGAGGFPG--FGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAA 437
           G  GI     GA GFPG     G  G  G  G  G  G PG+ G  G    P+ +   A 
Sbjct: 423 GAPGI----AGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQ-GPKGEPGPAG 477

Query: 438 KAAKYGLVPGVGVAPGVGVAPGVGV--APGVGLAPGVGVAPGVGVAPGVGVAPG-IGPGG 494
                G     G     G   GVG    PG   APG    PG     G   APG  GP G
Sbjct: 478 PQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSG 537

Query: 495 VAA--AAKSAAKVAAKAQLRAAAGL-----GAGIPGLGVGVGVPGLGVGAGVPGLGVGAG 547
           +A    A        +  L  A GL      AG  G     G PG     G PG     G
Sbjct: 538 LAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARG 597

Query: 548 VPGFGAVPGALAA----AKAAKYG-AAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAK 602
            PG    PG   A     KA + G    PG+ G  G  G  G  G    AGPA       
Sbjct: 598 QPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQG 657

Query: 603 AAAKAAQFGLVGAAGLGGLG--VGGLGVPGVGGLGGI 637
           A   +   GL G  G  G G   G  GVPG  G  G+
Sbjct: 658 APGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGL 694



 Score =  122 bits (306), Expect = 1e-27
 Identities = 159/504 (31%), Positives = 180/504 (35%), Gaps = 49/504 (9%)

Query: 200 APKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGY------PTGTGVGPQAAAAAAAKAA 253
           +P++P G   P     L    G  G  G  G+ G       P G   GPQ  A       
Sbjct: 77  SPEIPFGECCPICPTDLATASGQPGPKGQKGEPGDIKDIVGPKGPP-GPQGPAGEQGPRG 135

Query: 254 AKFGAGAAGVLPGVGGA----GVPGVPG--AIPGIGGIAGVGTPAAAAAAAA---AAKAA 304
            +   G  G  PG  G     G PG PG    PG  G  G+G   AA  A      A  A
Sbjct: 136 DRGDKGEKGA-PGPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGA 194

Query: 305 KYGAAAG-LVPGGPGFGPGVVGVPG----AGVPG-VGVPGAGIPVVPGAGIPGAAVPGVV 358
           + G   G + P GP   PG  G PG     G PG  G PG   P+ P  G PG   PG  
Sbjct: 195 QLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGP-RGPPGP--PGKP 251

Query: 359 SPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPG 418
             +  A    KA + G     G  G P    G  G PG   G  G PG+ G  G  G PG
Sbjct: 252 GDDGEAGKPGKAGERGPPGPQGARGFP----GTPGLPGV-KGHRGYPGLDGAKGEAGAPG 306

Query: 419 V---GGVPGVGISPEAQAAAAAKAAKYGLVP-GVGVAPGVGVAPGVGVAPG-VGLAPGVG 473
           V    G PG   SP           +    P G   A G    PG    PG VG A G G
Sbjct: 307 VKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPG 366

Query: 474 VAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGA-GIPGLGVGVGVPG 532
                G     G     GP G            +     A+   G  GIPG     G PG
Sbjct: 367 FPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPG 426

Query: 533 LGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPG--GVV 590
           +   AG PG     G PG     G L      K     PG+ G  G  G  G PG  G  
Sbjct: 427 I---AGAPGFPGPRGPPGPQGATGPL----GPKGQTGEPGIAGFKGEQGPKGEPGPAGPQ 479

Query: 591 GA-GPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYG 649
           GA GPA       A  +    G +G  G  G   G  G PG  GL G P  A  +    G
Sbjct: 480 GAPGPAGEEGKRGARGEPGGVGPIGPPGERG-APGNRGFPGQDGLAG-PKGAPGERGPSG 537

Query: 650 VAARPGFGLSPIFPGGACLGKACG 673
           +A   G    P  PG   L  A G
Sbjct: 538 LAGPKGANGDPGRPGEPGLPGARG 561


>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 1418

 Score =  157 bits (398), Expect = 2e-38
 Identities = 244/775 (31%), Positives = 275/775 (35%), Gaps = 200/775 (25%)

Query: 36  GVPGGVFYPALGPGGKPLKPVPGGLAG-------------AGLGAGLGAFPAVTFP-GAL 81
           G PG    P  GP G P  P P GL G             AG GA LG       P G  
Sbjct: 84  GEPGTPGNP--GPPGPPGPPGPPGLGGNFAAQMAGGFDEKAG-GAQLGVMQGPMGPMGPR 140

Query: 82  VPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVY- 140
            P G A A    +  +   G  G PGV G     G     PG   KPG     G PG   
Sbjct: 141 GPPGPAGAPGP-QGFQGNPGEPGEPGVSGPMGPRG----PPGPPGKPGDDGEAGKPGKAG 195

Query: 141 ---PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGA--FAGIPGV-------GPFGGP 188
              P G      FPG   LPGV    G     PG+ GA   AG PGV       G  G P
Sbjct: 196 ERGPPGPQGARGFPGTPGLPGVKGHRGY----PGLDGAKGEAGAPGVKGESGSPGENGSP 251

Query: 189 QPGVPLGYPIKAPKL--------------PGGYGLPYTTGKLPYGYGPG--GVAGAAGKA 232
            P  P G P +  +               PG  G P   G  P G GPG  G  GA G+A
Sbjct: 252 GPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVG--PAG-GPGFPGAPGAKGEA 308

Query: 233 GYPTGTGVGPQAAAAAAAKAAAKFGAGAAGV--------LPGV-GGAGVPGVPGA----- 278
           G PTG   GP+ A     +       G AG         +PG  G AG PG+ GA     
Sbjct: 309 G-PTGAR-GPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPG 366

Query: 279 ---------------------IPGIGGIAG----------VGTPAAAAAAAAAAKAAKYG 307
                                 PGI G  G           G   A   A    K    G
Sbjct: 367 PRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARG 426

Query: 308 AAAGLVPGGPGFGPGVVGVPG-AGVPG-------VGVPGA-------------GIPVVPG 346
              G+ P GP   PG  G PG  G PG        G PG              G P  PG
Sbjct: 427 EPGGVGPIGP---PGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPG 483

Query: 347 -AGIPGA----AVPGVVSPEAAAKAAAKAAKYGARPG----VGVGGIPTYGVGAGGFPGF 397
             G+PGA      PG   P+     +    + G RPG     G  G P    G  GFPG 
Sbjct: 484 EPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDG-RPGPPGPQGARGQP----GVMGFPG- 537

Query: 398 GVGVGGIPGVAGVPGVGGVPGVGGVPGV-----GISPEAQAAAAAKAAKYGLVPGVGVAP 452
             G  G PG AG  G+ G PG+ G+PG         P   A  A +  + G       AP
Sbjct: 538 PKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQG-------AP 590

Query: 453 GVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG-IGPGGVAAAAKSAAKVAAKAQL 511
           G     G+   PG    PG G  PG    PG   APG +GP G            A+  L
Sbjct: 591 GPSGFQGLPGPPG---PPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQG-L 646

Query: 512 RAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAA------- 564
           +   GL  G PG     G  G    AG PG     G PG   +PG   AA  A       
Sbjct: 647 QGPRGL-PGTPGTD---GPKGASGPAGPPG---AQGPPGLQGMPGERGAAGIAGPKGDRG 699

Query: 565 ----KYGAAVPGVLGGLGALGGVGIPG--------GVVG-AGPAAAAAAAKAAAKAAQFG 611
               K     PG  GG G  G +G PG        G VG  GPA +A A  A  +  + G
Sbjct: 700 DVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETG 759

Query: 612 LVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGA 666
             G AG  G   G  G PG  G  G       +A + G A  PG    P  P GA
Sbjct: 760 PPGPAGFAG-PPGADGQPGAKGEQG-------EAGQKGDAGAPG----PQGPSGA 802



 Score =  155 bits (392), Expect = 1e-37
 Identities = 213/679 (31%), Positives = 243/679 (35%), Gaps = 93/679 (13%)

Query: 28  GVPGAIPGGVPGGVFYP--ALGPGGKPLKPVPGGLAGAGLGAGLGAFP------------ 73
           G PGA     P G   P  A GP G+P  P   G AGA    G    P            
Sbjct: 300 GAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIA 359

Query: 74  -AVTFPGALVPGGVADAAAAY--KAAKAGAGLGGVPGVGGLGVSAGAVVPQ--PGAGVKP 128
            A  FPG   P G   A      K      G+ G  G  G     G   PQ  PG   + 
Sbjct: 360 GAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEE 419

Query: 129 GKVPGVGLP-GVYPGGVLPGAR-FPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFG 186
           GK    G P GV P G  PG R  PG    PG    AG K  APG  G  +G+ G     
Sbjct: 420 GKRGARGEPGGVGPIGP-PGERGAPGNRGFPGQDGLAGPK-GAPGERGP-SGLAGPKGAN 476

Query: 187 GPQPGVPLGYPIKAPKLPGGYGLPYTTGKL-PYG-YGPGGVAGAAGKAGYPTGTGVGPQA 244
           G  PG P       P LPG  GL    G   P G  GP G  G  G+ G P     GPQ 
Sbjct: 477 G-DPGRP-----GEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPP-----GPQG 525

Query: 245 AAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPG--AIPGIGGIAGVGTPAAAAAAAAAAK 302
           A             GA G     G  G+PG PG   +PG  G  G   P     A  A +
Sbjct: 526 ARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGP--PGPAGPAGE 583

Query: 303 AAKYGAAAGLVPGGPGFG--PGVVGVPGAGVPGVGVPGAGIPVVPGAGIPG-AAVPGVVS 359
             + GA     PG  GF   PG  G PG G    G PG         G+PG A  PG+V 
Sbjct: 584 RGEQGA-----PGPSGFQGLPGPPGPPGEG----GKPG-------DQGVPGEAGAPGLVG 627

Query: 360 PEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGV 419
           P        +    GA+   G  G+P  G      P    G  G PG  G PG+ G+PG 
Sbjct: 628 PRGERGFPGERGSPGAQGLQGPRGLP--GTPGTDGPKGASGPAGPPGAQGPPGLQGMPGE 685

Query: 420 GGVPGVG--------ISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPG 471
            G  G+         +  +    A  K    GL   +G  PG   A G     G    PG
Sbjct: 686 RGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIG-PPGPAGANGEKGEVG---PPG 741

Query: 472 VGVAPGVGVAPGV-GVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLG-AGIPGLGVGVG 529
              + G   APG  G     GP G A    +  +  AK +   A   G AG PG     G
Sbjct: 742 PAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSG 801

Query: 530 VPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGV 589
            PG     GV G     G  G    PGA             PG  G +G  G  G PG  
Sbjct: 802 APGPQGPTGVTG---PKGARGAQGPPGA----------TGFPGAAGRVGPPGSNGNPGPP 848

Query: 590 VGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLG--VGGLGVPGVGGLGGI--PPAAAAKA 645
              GP+       A   +   G  G  GL G     G  G PG  G  G   PP     A
Sbjct: 849 GPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLA 908

Query: 646 AKYGVAARPGFGLSPIFPG 664
            + G+   PG      FPG
Sbjct: 909 GQRGIVGLPGQRGERGFPG 927



 Score =  145 bits (367), Expect = 9e-35
 Identities = 223/677 (32%), Positives = 251/677 (37%), Gaps = 108/677 (15%)

Query: 26   PGGV-PGAIPG--GVPGGVFYPA----LGPGGKPLKPVPGGLAGA-GLGAGLGAFPAVTF 77
            PGGV P   PG  G PG   +P      GP G P +  P GLAG  G     G       
Sbjct: 428  PGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGL 487

Query: 78   PGAL-VPGGVADAAAAYKAAKAGA-GLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVG 135
            PGA  + G   DA    K   +GA G  G PG  G   + G    QPG    PG     G
Sbjct: 488  PGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARG----QPGVMGFPGPKGANG 543

Query: 136  LPGVYPGGVLPGARFPGVGVLPGVP--TGAGVKPKAPGVGGAFA--GIPGVGPFGGPQPG 191
             PG      LPGA  PG+  LPG    TGA   P   G  G     G PG   F G  PG
Sbjct: 544  EPGKAGEKGLPGA--PGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQG-LPG 600

Query: 192  VPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAA 250
             P G P +  K PG  G+P   G  P   GP G  G  G+ G P   G+ GP+       
Sbjct: 601  PP-GPPGEGGK-PGDQGVPGEAGA-PGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPG 657

Query: 251  KAAAKFGAGAAGVLPGVGGA----GVPGVPGAIPGIGGIAG-VGTPAAAAAAAAAAKAAK 305
                K  +G AG  PG  G     G+PG  GA  GI G  G  G         A  K   
Sbjct: 658  TDGPKGASGPAGP-PGAQGPPGLQGMPGERGA-AGIAGPKGDRGDVGEKGPEGAPGKDGG 715

Query: 306  YGAAAGLVPGGPGFG---------PGVVGVPGA-GVPG----VGVPG-AGIPVVPGA-GI 349
             G    + P GP            PG  G  GA G PG     G PG AG    PGA G 
Sbjct: 716  RGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQ 775

Query: 350  PG-------------AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPG 396
            PG             A  PG   P  A          G +   G  G P    GA GFPG
Sbjct: 776  PGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPP----GATGFPG 831

Query: 397  FGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGL-----VPGVGVA 451
               G  G PG  G PG  G PG  G  G        +    +A + GL      PG    
Sbjct: 832  -AAGRVGPPGSNGNPGPPGPPGPSGKDGPK-GARGDSGPPGRAGEPGLQGPAGPPGEKGE 889

Query: 452  PGVGVAPGVGVAPG-VGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQ 510
            PG     G    PG  GLA   G+  G+    G    PG+ PG      K  A  A+  +
Sbjct: 890  PGDDGPSGAEGPPGPQGLAGQRGIV-GLPGQRGERGFPGL-PGPSGEPGKQGAPGASGDR 947

Query: 511  LRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAV 570
                     G PG    VG PGL   AG PG     G PG    PG   A       A V
Sbjct: 948  ---------GPPG---PVGPPGLTGPAGEPG---REGSPGADGPPGRDGA-------AGV 985

Query: 571  PGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAG-LGGLGV------ 623
             G  G  GA+G  G PG     GPA          +A   G +G +G  G  G+      
Sbjct: 986  KGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGP 1045

Query: 624  ----GGLGVPGVGGLGG 636
                G  G PG  GL G
Sbjct: 1046 RGDKGEAGEPGERGLKG 1062



 Score =  142 bits (357), Expect = 1e-33
 Identities = 221/705 (31%), Positives = 256/705 (36%), Gaps = 120/705 (17%)

Query: 23   PSRPG--GVPGAI-----PGGV-PGGVFYPALGPG--GKPLKPVPGGLAGAGLGAGLGAF 72
            P RPG  G+PGA      PG   P G   P+  PG  G+P  P P G  G     G+  F
Sbjct: 479  PGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQ---PGVMGF 535

Query: 73   PAVT-------------FPGAL----VPGGVADAAAAYKAAKAGA----GLGGVPGVGGL 111
            P                 PGA     +PG   +  AA     AG     G  G PG  G 
Sbjct: 536  PGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGF 595

Query: 112  GVSAGAVVPQPGAGVKPGK--VPG-VGLPGV--------YPGGV-LPGAR-FPGVGVLPG 158
                G   P PG G KPG   VPG  G PG+        +PG    PGA+   G   LPG
Sbjct: 596  QGLPGPPGP-PGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPG 654

Query: 159  VPTGAGVKPKA-----PGVGG--AFAGIPG-------VGPFGGPQPGVPLGYPIKAPKLP 204
             P   G K  +     PG  G     G+PG        GP  G +  V    P  AP   
Sbjct: 655  TPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGP-KGDRGDVGEKGPEGAPGKD 713

Query: 205  GGYGLPYTTGKL-PYG-------YGPGGVAGAAGKAGYPTGTG-VGPQAAAAAAAKAAAK 255
            GG GL    G   P G        GP G AG+AG  G P   G  GP   A  A    A 
Sbjct: 714  GGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGAD 773

Query: 256  FGAGAAGVLPGVGGAGVPGVPG-----AIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAA 310
               GA G     G  G  G PG       PG  G  GV  P  A  A     A  +  AA
Sbjct: 774  GQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAA 833

Query: 311  GLV-PGGPGFGPGVVGVPGA----GVPGV----GVPG-AGIPVVPG-AGIPGA-AVPGVV 358
            G V P G    PG  G PG     G  G     G PG AG P + G AG PG    PG  
Sbjct: 834  GRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDD 893

Query: 359  SPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPG 418
             P  A          G R   G+ G+P    G  GFPG       +PG +G PG  G PG
Sbjct: 894  GPSGAEGPPGPQGLAGQR---GIVGLPGQR-GERGFPG-------LPGPSGEPGKQGAPG 942

Query: 419  VGGVPGVG--ISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAP 476
              G  G    + P      A +  + G       +PG    PG   A GV    G   A 
Sbjct: 943  ASGDRGPPGPVGPPGLTGPAGEPGREG-------SPGADGPPGRDGAAGVKGDRGETGAV 995

Query: 477  GVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGA-GIPGLGVGVGVPGLGV 535
            G   APG   +PG  P G         +  A+  +  +   GA GI G     G  G   
Sbjct: 996  GAPGAPGPPGSPG--PAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAG 1053

Query: 536  GAGVPGLGVGAGVPGFGAVPGAL-------AAAKAAKYGA-AVPGVLGGLGALGGVGIPG 587
              G  GL    G  G   +PG         A+  A   G    PG +G  G  G  GIPG
Sbjct: 1054 EPGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPG 1113

Query: 588  GVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVG 632
             +   GP   +     A      G  G  G  G G+      G+G
Sbjct: 1114 PIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLG 1158



 Score =  128 bits (321), Expect = 2e-29
 Identities = 185/577 (32%), Positives = 207/577 (35%), Gaps = 58/577 (10%)

Query: 94  KAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGV 153
           K A    G  G PG  G           PG    PG     GL G +   +  G      
Sbjct: 74  KGAPGPRGRDGEPGTPG----------NPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAG 123

Query: 154 GVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGP-----QPGV--PLGYPIKAPKLPGG 206
           G   GV  G  + P  P      AG PG   F G      +PGV  P+G P   P  PG 
Sbjct: 124 GAQLGVMQGP-MGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMG-PRGPPGPPGK 181

Query: 207 YGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGAGAAGVLP 265
            G     GK P   G  G  G  G  G+P   G+ G +          AK  AGA GV  
Sbjct: 182 PGDDGEAGK-PGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKG 240

Query: 266 GVGGAGVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVV 324
             G  G  G PG + G  G+ G  G    A AA A     + G A    P GP  GPG  
Sbjct: 241 ESGSPGENGSPGPM-GPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFP 299

Query: 325 GVPG----AGVPGV-GVPGAGIPVVPGAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGV 379
           G PG    AG  G  G  GA  P     G PG   PG   P  A+         GA+   
Sbjct: 300 GAPGAKGEAGPTGARGPEGAQGP----RGEPG--TPGSPGPAGASGNPGTDGIPGAKGSA 353

Query: 380 GVGGIPTYGVGAGGFPG--FGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAA 437
           G  GI     GA GFPG     G  G  G  G  G  G PG+ G  G    P+ +   A 
Sbjct: 354 GAPGI----AGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQ-GPKGEPGPAG 408

Query: 438 KAAKYGLVPGVGVAPGVGVAPGVGV--APGVGLAPGVGVAPGVGVAPGVGVAPG-IGPGG 494
                G     G     G   GVG    PG   APG    PG     G   APG  GP G
Sbjct: 409 PQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSG 468

Query: 495 VAA--AAKSAAKVAAKAQLRAAAGL-----GAGIPGLGVGVGVPGLGVGAGVPGLGVGAG 547
           +A    A        +  L  A GL      AG  G     G PG     G PG     G
Sbjct: 469 LAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARG 528

Query: 548 VPGFGAVPGALAA----AKAAKYG-AAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAK 602
            PG    PG   A     KA + G    PG+ G  G  G  G  G    AGPA       
Sbjct: 529 QPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQG 588

Query: 603 AAAKAAQFGLVGAAGLGGLG--VGGLGVPGVGGLGGI 637
           A   +   GL G  G  G G   G  GVPG  G  G+
Sbjct: 589 APGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGL 625



 Score =  120 bits (302), Expect = 3e-27
 Identities = 152/476 (31%), Positives = 170/476 (35%), Gaps = 47/476 (9%)

Query: 222 PGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGA----GVPGVPG 277
           PG +    G  G P     GPQ  A        +   G  G  PG  G     G PG PG
Sbjct: 40  PGDIKDIVGPKGPP-----GPQGPAGEQGPRGDRGDKGEKGA-PGPRGRDGEPGTPGNPG 93

Query: 278 --AIPGIGGIAGVGTPAAAAAAAA---AAKAAKYGAAAG-LVPGGPGFGPGVVGVPG--- 328
               PG  G  G+G   AA  A      A  A+ G   G + P GP   PG  G PG   
Sbjct: 94  PPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQG 153

Query: 329 -AGVPG-VGVPGAGIPVVPGAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPT 386
             G PG  G PG   P+ P  G PG   PG    +  A    KA + G     G  G P 
Sbjct: 154 FQGNPGEPGEPGVSGPMGP-RGPPGP--PGKPGDDGEAGKPGKAGERGPPGPQGARGFP- 209

Query: 387 YGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGV---GGVPGVGISPEAQAAAAAKAAKYG 443
              G  G PG   G  G PG+ G  G  G PGV    G PG   SP           +  
Sbjct: 210 ---GTPGLPGV-KGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGR 265

Query: 444 LVP-GVGVAPGVGVAPGVGVAPG-VGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKS 501
             P G   A G    PG    PG VG A G G     G     G     GP G       
Sbjct: 266 TGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGE 325

Query: 502 AAKVAAKAQLRAAAGLGA-GIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAA 560
                +     A+   G  GIPG     G PG+   AG PG     G PG     G L  
Sbjct: 326 PGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGI---AGAPGFPGPRGPPGPQGATGPL-- 380

Query: 561 AKAAKYGAAVPGVLGGLGALGGVGIPG--GVVGA-GPAAAAAAAKAAAKAAQFGLVGAAG 617
               K     PG+ G  G  G  G PG  G  GA GPA       A  +    G +G  G
Sbjct: 381 --GPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPPG 438

Query: 618 LGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGACLGKACG 673
             G   G  G PG  GL G P  A  +    G+A   G    P  PG   L  A G
Sbjct: 439 ERG-APGNRGFPGQDGLAG-PKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARG 492


>gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]
          Length = 1499

 Score =  152 bits (384), Expect = 1e-36
 Identities = 224/723 (30%), Positives = 257/723 (35%), Gaps = 145/723 (20%)

Query: 28   GVPGAI-PGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGV 86
            G+PGAI   G PG     A GP G P    P G AG     G          G+  P G+
Sbjct: 417  GLPGAIGTDGTPG-----AKGPTGSPGTSGPPGSAGPPGSPGP--------QGSTGPQGI 463

Query: 87   ADAAA--AYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVK-PGKVPG-VGLPGVYPG 142
                        K  AG  G PG  G+    G + P    G + P   PG VG PG    
Sbjct: 464  RGQPGDPGVPGFKGEAGPKGEPGPHGI---QGPIGPPGEEGKRGPRGDPGTVGPPGPVGE 520

Query: 143  GVLPGAR-FPGVGVLPGVPTGA----------GVK--------PKAPGVGGA--FAGIPG 181
               PG R FPG   LPG P GA          G K        P  PG+ GA    G PG
Sbjct: 521  RGAPGNRGFPGSDGLPG-PKGAQGERGPVGSSGPKGSQGDPGRPGEPGLPGARGLTGNPG 579

Query: 182  V-------GPFGGP----QPGVPLGYPIKAPKLPGGYGLPYTTGKL--PYGYGPGGVAGA 228
            V       GP G P    +PG P    I+    PG  GLP   G    P   G  G AG 
Sbjct: 580  VQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQ--PGSMGLPGPKGSSGDPGKPGEAGNAGV 637

Query: 229  AGKAGYPTGTG-VGPQAAAAAAAKAAAKFGAGAAGVL-----------PGVGGA----GV 272
             G+ G P   G VGP         A  +   G  G             PG GG     GV
Sbjct: 638  PGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKPGDQGV 697

Query: 273  PGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG-AGV 331
            PG PGA+  +G     G P             + G A G  P GP   PG  G PG  G 
Sbjct: 698  PGDPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGSPGPSGTPGDTGP 757

Query: 332  PGV-GVPG-AGIPVVPG----------------AGIPGA-AVPGVVSPEAAAKAAAKAAK 372
            PG+ G+PG  GI   PG                AG  GA  +PG + P   A    +  +
Sbjct: 758  PGLQGMPGERGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGE 817

Query: 373  YGARPGVGVGGI-----------PTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGG 421
             G R  VG  G            PT   GA GF G   G  G PGV G PG  G  G  G
Sbjct: 818  PGPRGLVGPPGSRGNPGSRGENGPT---GAVGFAG-PQGPDGQPGVKGEPGEPGQKGDAG 873

Query: 422  VPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPG-VGLAPGVGVAPGVGV 480
             PG    P+  A +       G VPG+    G    PG    PG  G     G A   G 
Sbjct: 874  SPG----PQGLAGSPGPHGPNG-VPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGP 928

Query: 481  APGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLG-------------------AGI 521
            A  +G     GP G+     S  +V  +       G G                   AG 
Sbjct: 929  AGPLGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAGT 988

Query: 522  PGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALG 581
             G    VG+PG     G+PGL   AG PG     GA             PG +G  G+ G
Sbjct: 989  TGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATG-------DKGPPGPVGPPGSNG 1041

Query: 582  GVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAA 641
             VG PG    AG         A  +    G  G AGL     G  G PG  G  G P  A
Sbjct: 1042 PVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGL----PGSQGAPGTPGPVGAPGDA 1097

Query: 642  AAK 644
              +
Sbjct: 1098 GQR 1100



 Score =  138 bits (347), Expect = 2e-32
 Identities = 227/756 (30%), Positives = 272/756 (35%), Gaps = 165/756 (21%)

Query: 23  PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGL--------AGAGLGAGLGAFPA 74
           P  P G+ G    GVPG    P  GP G P  P P GL        AG    +GLG+   
Sbjct: 154 PRGPQGIDGE--PGVPGQPGAP--GPPGHPSHPGPDGLSRPFSAQMAGLDEKSGLGSQVG 209

Query: 75  VTFPGALVPGGVADAAAAYKAAKAGAGLGGVPG-------VGGLGVSAGAVVP--QPGAG 125
           +  PG++ P G        +  + GAG  G PG       +G +G S G   P  +PG  
Sbjct: 210 L-MPGSVGPVGPR-GPQGLQGQQGGAGPTGPPGEPGDPGPMGPIG-SRGPEGPPGKPGED 266

Query: 126 VKPGKVPGVGLPGVYPGGVLPGAR-FPGVGVLPGVPTGAGVK----PKAP-GVGGAFAGI 179
            +PG+    G PG       PGAR FPG   LPG+    G K    PK   G  G+    
Sbjct: 267 GEPGRN---GNPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGEVGAPGSKGEA 323

Query: 180 PGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGK--LPYGYGPGGVAGAAGKAGYPTG 237
              GP G   P  P G P +  +L G  G P   G   +P   GP G  G  G +G+P  
Sbjct: 324 GPTGPMGAMGPLGPRGMPGERGRL-GPQGAPGQRGAHGMPGKPGPMGPLGIPGSSGFPGN 382

Query: 238 TGVGPQAAAAAAAKAAAKFGAGAAGVLPG-VGGAGVP------GVPGA-----IPGIGGI 285
            G+  +A    A       G       PG VG  G+P      G PGA      PG  G 
Sbjct: 383 PGMKGEAGPTGARGPEGPQGQRGETGPPGPVGSPGLPGAIGTDGTPGAKGPTGSPGTSGP 442

Query: 286 AG-------------------------VGTPAAAAAAAAAAKAAKYGAAAGLVP------ 314
            G                          G P     A    +   +G    + P      
Sbjct: 443 PGSAGPPGSPGPQGSTGPQGIRGQPGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGK 502

Query: 315 GGPGFGPGVVGVPG----AGVPG-VGVPGA-GIPVVPGA--------------------- 347
            GP   PG VG PG     G PG  G PG+ G+P   GA                     
Sbjct: 503 RGPRGDPGTVGPPGPVGERGAPGNRGFPGSDGLPGPKGAQGERGPVGSSGPKGSQGDPGR 562

Query: 348 ----GIPGA----AVPGVVSPEAAAKAAAKAAKYGARPG----VGVGGIPTYGVGAGGFP 395
               G+PGA      PGV  PE          + G RPG    +G+ G P    G+ G P
Sbjct: 563 PGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDG-RPGPPGSIGIRGQP----GSMGLP 617

Query: 396 GFGVGVGGIPGVAGVPGVGGVPGVGGVPG----VGIS-PEAQAAAAAKAAKYGL------ 444
           G   G  G PG  G  G  GVPG  G PG    VG S P      A +  + G       
Sbjct: 618 G-PKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGF 676

Query: 445 --VPGVGVAPGVGVAPGVGVAPGVGLA------------PGVGVAPGVGVAPG-VGVAPG 489
             +PG    PG G  PG    PG   A            PG    PG+   PG  G+A G
Sbjct: 677 QGLPGPPGPPGEGGKPGDQGVPGDPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGG 736

Query: 490 IGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGL---GVGAGVPGLGVGA 546
            GP G     K +   +         GL  G+PG     G PG      G G  G    A
Sbjct: 737 HGPDG----PKGSPGPSGTPGDTGPPGL-QGMPGERGIAGTPGPKGDRGGIGEKGAEGTA 791

Query: 547 GVPGFGAVPGALA----AAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAK 602
           G  G   +PG L     A    + G   PG  G +G  G  G PG     GP  A   A 
Sbjct: 792 GNDGARGLPGPLGPPGPAGPTGEKGE--PGPRGLVGPPGSRGNPGSRGENGPTGAVGFAG 849

Query: 603 AAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIP 638
                 Q G+ G  G  G   G  G PG  GL G P
Sbjct: 850 PQGPDGQPGVKGEPGEPG-QKGDAGSPGPQGLAGSP 884



 Score =  128 bits (321), Expect = 2e-29
 Identities = 216/707 (30%), Positives = 252/707 (35%), Gaps = 137/707 (19%)

Query: 23   PSRPG--GVPGA--IPG--GVPG--GVFYPALGPG--GKPLKPVPGGLAGAGLGAGLGAF 72
            P RPG  G+PGA  + G  GV G  G   P   PG  G+P  P   G+ G     GL   
Sbjct: 560  PGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGL--- 616

Query: 73   PAVTFPGALVPGGVADAAAAYKAAKAGA-GLGGVPGVGGLGVSAGAVVPQPGAGVKPGKV 131
                 PG    G   D     +A  AG  G  G PG  G    +G V P PG   + G+ 
Sbjct: 617  -----PGP--KGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGP-PGLAGERGEQ 668

Query: 132  PGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPG-VGPFGGPQP 190
               G PG  P G      F G+   PG P G G KP   GV G     PG VGP G   P
Sbjct: 669  ---GPPG--PTG------FQGLPGPPG-PPGEGGKPGDQGVPGD----PGAVGPLG---P 709

Query: 191  GVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-------GPQ 243
                G P +  + PG  GLP   G +  G+GP G  G+ G +G P  TG        G +
Sbjct: 710  RGERGNPGERGE-PGITGLPGEKG-MAGGHGPDGPKGSPGPSGTPGDTGPPGLQGMPGER 767

Query: 244  AAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAI--PGIGGIAG----------VGTP 291
              A        + G G  G     G  G  G+PG +  PG  G  G          VG P
Sbjct: 768  GIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVGPP 827

Query: 292  AAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG----------------AGVPGV- 334
             +     +  +    GA     P GP   PGV G PG                AG PG  
Sbjct: 828  GSRGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPH 887

Query: 335  ---GVPGA----GIPVVPGA-GIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPT 386
               GVPG     G    PGA G PG+A  G V P   A A   A   G     G  G P 
Sbjct: 888  GPNGVPGLKGGRGTQGPPGATGFPGSA--GRVGPPGPAGAPGPAGPLGEP---GKEGPP- 941

Query: 387  YGVGAGGFPGFGVGVG--GIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGL 444
               G  G PG    VG  G  G  G PG  G PG  G PG    P+     A    + G+
Sbjct: 942  ---GLRGDPGSHGRVGDRGPAGPPGGPGDKGDPGEDGQPG----PDGPPGPAGTTGQRGI 994

Query: 445  V--PGVGVAPGVGVAPGVGVAPG----VGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAA 498
            V  PG     G+   PG    PG     G     G    VG     G     GP G A  
Sbjct: 995  VGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGPPGPVGPPGSNGPVGEPGPEGPAGN 1054

Query: 499  AKSAAKVAAKAQLR-----AAAGL--GAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGF 551
              +  +  A  +         AGL    G PG    VG PG     G PG     G PG 
Sbjct: 1055 DGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPGPVGAPGDAGQRGDPGSRGPIGPPGR 1114

Query: 552  GA---VPGALAA-AKAAKYG----------------AAVPGVLGGLGALGGVGIPGGVVG 591
                 +PG          +G                  +PG  G  G  G  GIPG    
Sbjct: 1115 AGKRGLPGPQGPRGDKGDHGDRGDRGQKGHRGFTGLQGLPGPPGPNGEQGSAGIPGPFGP 1174

Query: 592  AGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIP 638
             GP      +         G +G  G+ G  VG  G  G  G  G P
Sbjct: 1175 RGPPGPVGPSGKEGNPGPLGPIGPPGVRG-SVGEAGPEGPPGEPGPP 1220



 Score =  122 bits (306), Expect = 1e-27
 Identities = 196/610 (32%), Positives = 225/610 (36%), Gaps = 57/610 (9%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALV 82
            PS P G PG    G  G    P  GP G    P P G  G G   G    P    PGA+ 
Sbjct: 652  PSGPVGPPGL--AGERGEQGPP--GPTGFQGLPGPPGPPGEGGKPGDQGVPGD--PGAVG 705

Query: 83   PGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQ--PGAGVKPGKVPGVGLPGVY 140
            P G           +   G+ G+PG  G+    G   P+  PG    PG     GL G  
Sbjct: 706  PLGPR-GERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGSPGPSGTPGDTGPPGLQG-- 762

Query: 141  PGGVLPGARFPGVGVLPGVPTG--AGVKPK-APGVGG--AFAGIPGVGPFGGPQPGVPLG 195
                +PG R  G+   PG P G   G+  K A G  G     G+PG  P G P P  P G
Sbjct: 763  ----MPGER--GIAGTPG-PKGDRGGIGEKGAEGTAGNDGARGLPG--PLGPPGPAGPTG 813

Query: 196  YPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAK 255
               + P   G  G P + G  P   G  G  GA G AG P G   G         +   K
Sbjct: 814  EKGE-PGPRGLVGPPGSRGN-PGSRGENGPTGAVGFAG-PQGPD-GQPGVKGEPGEPGQK 869

Query: 256  FGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVP 314
              AG+ G   G+ G+  P  P  +PG+ G  G  G P A     +A +    G A    P
Sbjct: 870  GDAGSPGP-QGLAGSPGPHGPNGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGP 928

Query: 315  GGPGFGPGVVGVPGA-GVPG----VGVPG-AGIPVVPG-AGIPGA-AVPGVVSPEAAAKA 366
             GP   PG  G PG  G PG    VG  G AG P  PG  G PG    PG   P   A  
Sbjct: 929  AGPLGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAGT 988

Query: 367  AAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVG 426
              +    G     G  G+P    G  G PG  VG  G  G  G PG  G PG  G  G  
Sbjct: 989  TGQRGIVGMPGQRGERGMPGLP-GPAGTPG-KVGPTGATGDKGPPGPVGPPGSNGPVGEP 1046

Query: 427  ISPEAQAAAAAKAAKYGLVPGVGVA--PGVGVAPGVGVAPGVGLAPGVGVAPG-VGVAPG 483
              PE  A       + G V   G    PG    PG   APG    PG   APG  G    
Sbjct: 1047 -GPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGT---PGPVGAPGDAGQRGD 1102

Query: 484  VGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLG-AGIPGLGVGVGVPGLGVGAGVPGL 542
             G    IGP G A           +         G  G  G     G+ GL    G  G 
Sbjct: 1103 PGSRGPIGPPGRAGKRGLPGPQGPRGDKGDHGDRGDRGQKGHRGFTGLQGLPGPPGPNGE 1162

Query: 543  GVGAGVPG-FG--AVPGALA-AAKAAKYGA----AVPGVLGGLGALGGVGIPGGVVGAGP 594
               AG+PG FG    PG +  + K    G       PGV G +G  G  G PG     GP
Sbjct: 1163 QGSAGIPGPFGPRGPPGPVGPSGKEGNPGPLGPIGPPGVRGSVGEAGPEGPPGEPGPPGP 1222

Query: 595  AAAAAAAKAA 604
                    AA
Sbjct: 1223 PGPPGHLTAA 1232



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 144/494 (29%), Positives = 176/494 (35%), Gaps = 44/494 (8%)

Query: 204 PGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGV 263
           PGG    +  G+      PG V    G  G P   G  P  +     +   K   G  G 
Sbjct: 100 PGGGNTNFGRGRKGQKGEPGLVPVVTGIRGRPGPAG--PPGSQGPRGERGPKGRPGPRGP 157

Query: 264 LPGVGGAGVPGVPGA-----IPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPG 318
               G  GVPG PGA      P   G  G+  P +A  A    K+   G+  GL+PG  G
Sbjct: 158 QGIDGEPGVPGQPGAPGPPGHPSHPGPDGLSRPFSAQMAGLDEKSG-LGSQVGLMPGSVG 216

Query: 319 -FGP-GVVGVPG--AGVPGVGVPGAGIPVVPGAGIPGAAVP-GVVSPEAAAKAAAKAAKY 373
             GP G  G+ G   G    G PG         G PG   P G   PE       +  + 
Sbjct: 217 PVGPRGPQGLQGQQGGAGPTGPPGE-------PGDPGPMGPIGSRGPEGPPGKPGEDGEP 269

Query: 374 G--ARPG-VGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGV--GIS 428
           G    PG VG  G P    GA GFPG   G+ G+ G  G  G+ G  G  G PG      
Sbjct: 270 GRNGNPGEVGFAGSP----GARGFPG-APGLPGLKGHRGHKGLEGPKGEVGAPGSKGEAG 324

Query: 429 PEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAP 488
           P     A       G+ PG     G   APG   A G+   PG     G+  + G    P
Sbjct: 325 PTGPMGAMGPLGPRGM-PGERGRLGPQGAPGQRGAHGMPGKPGPMGPLGIPGSSGFPGNP 383

Query: 489 GI-GPGGVAAAAKSAAKVAAKAQLRAAAGLGA-GIPGLGVGVGVPGLGVGAGVPGLGVGA 546
           G+ G  G   A         + +      +G+ G+PG     G PG     G PG    +
Sbjct: 384 GMKGEAGPTGARGPEGPQGQRGETGPPGPVGSPGLPGAIGTDGTPGAKGPTGSPGT---S 440

Query: 547 GVPGFGAVPGA-----LAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAA 601
           G PG    PG+         +  +     PGV G  G  G  G PG     GP       
Sbjct: 441 GPPGSAGPPGSPGPQGSTGPQGIRGQPGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEE 500

Query: 602 KAAAKAAQFGLVGAAG-LGGLGV-GGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLS 659
                    G VG  G +G  G  G  G PG  GL G P  A  +    G +   G    
Sbjct: 501 GKRGPRGDPGTVGPPGPVGERGAPGNRGFPGSDGLPG-PKGAQGERGPVGSSGPKGSQGD 559

Query: 660 PIFPGGACLGKACG 673
           P  PG   L  A G
Sbjct: 560 PGRPGEPGLPGARG 573



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 124/402 (30%), Positives = 139/402 (34%), Gaps = 64/402 (15%)

Query: 23   PSRPGGVPGAIPG----GVPGGVFYPA----LGPGGKPLKPVPGGLAGA-------GLGA 67
            P  P GVPG   G    G PG   +P     +GP G    P P G  G        GL  
Sbjct: 886  PHGPNGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRG 945

Query: 68   GLGAFPAVTFPG-ALVPGGVADAAAAYKAAKAG-------AGLGGVPGVGGLGVSAG--A 117
              G+   V   G A  PGG  D     +  + G       AG  G  G+ G+    G   
Sbjct: 946  DPGSHGRVGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERG 1005

Query: 118  VVPQPGAGVKPGKVPGVGLPGVY--PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGA 175
            +   PG    PGKV   G  G    PG V P      VG  PG P G       PG  GA
Sbjct: 1006 MPGLPGPAGTPGKVGPTGATGDKGPPGPVGPPGSNGPVGE-PG-PEGPAGNDGTPGRDGA 1063

Query: 176  FAGIPGVGPFGGPQPGVPLGYPIK--APKLPGGYGLPYTTGKL--PYGYGPGGVAGAAGK 231
                  VG  G      P G P    AP  PG  G P   G+   P   GP G  G AGK
Sbjct: 1064 ------VGERGDRGDPGPAGLPGSQGAPGTPGPVGAPGDAGQRGDPGSRGPIGPPGRAGK 1117

Query: 232  AGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAG-VGT 290
             G P     GPQ           +   G  G     G  G+ G+PG  PG  G  G  G 
Sbjct: 1118 RGLP-----GPQGPRGDKGDHGDRGDRGQKGHR---GFTGLQGLPGP-PGPNGEQGSAGI 1168

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIP 350
            P               G      P GP   PGV G  G   P  G PG   P  P  G P
Sbjct: 1169 PGPFGPRGPPGPVGPSGKEGNPGPLGPIGPPGVRGSVGEAGP-EGPPGEPGPPGP-PGPP 1226

Query: 351  G---AAVPGVVS----------PEAAAKAAAKAAKYGARPGV 379
            G   AA+  ++           PE     AA   K    PGV
Sbjct: 1227 GHLTAALGDIMGHYDESMPDPLPEFTEDQAAPDDKNKTDPGV 1268


>gi|48762934 alpha 2 type I collagen [Homo sapiens]
          Length = 1366

 Score =  152 bits (383), Expect = 1e-36
 Identities = 205/667 (30%), Positives = 239/667 (35%), Gaps = 89/667 (13%)

Query: 26  PGGVPGAIPGGVPGGVFYPALGPG-----GKPLKPVPGGLAGAGLGAGLGAFPAVTFPGA 80
           P G PG      P G   PA  PG     G P KP   G  G     G   FP    PG 
Sbjct: 116 PAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGT--PG- 172

Query: 81  LVPGGVADAAAAYKAAKAGAGLGGV---PGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLP 137
            +PG        +K  +   GL G+   PG  G+    GA    PG    PG+    GLP
Sbjct: 173 -LPG--------FKGIRGHNGLDGLKGQPGAPGVKGEPGA----PGENGTPGQTGARGLP 219

Query: 138 GV-----YPGGVLPGARFPGVG-VLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPG 191
           G       PG          VG V P  P G+   P  PG  G    I  VG  G   P 
Sbjct: 220 GERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPA 279

Query: 192 VPLGYPIKAPKLPGGYGLPYTTGK--LPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAA 248
            P G  +  P L G  G P   G   L    G  G+ G AG  G P   G+ GP  AA A
Sbjct: 280 GPRG-EVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGA 338

Query: 249 AAKAAAKFGAGAAGVLPGVGGAGVPGV--PGAIPGIGGIAGVGTPAAAAAAAAAAKAAKY 306
                     G AG     G  G PG   P   PG  G  G   P   A +A        
Sbjct: 339 TGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGP------ 392

Query: 307 GAAAGLVPGGPGF--GPGVVGVPGA-GVPGV-GVPG-------AGIPVVPG-AGIPGAAV 354
                  PG PG    PG  G+PGA G  GV G PG       AG+    G AG PG   
Sbjct: 393 -------PGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGE-- 443

Query: 355 PGVVSPEAAAKAAAKAAKYGARPGVGVGGI-----PTYGVGAGGFPGFGVGVGGIPGVAG 409
           PG++ P     +       G    VG+ GI     P    GA G PG  +G  G  G  G
Sbjct: 444 PGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPG-NIGFPGPKGPTG 502

Query: 410 VPGVGGVPGVGGVPGV--GISPEAQAAAAAKAAKYGLVPGVGV-----APGVGVAPG-VG 461
            PG  G  G  G+ G      P+    A       G+  G G       PG    PG  G
Sbjct: 503 DPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLPGPSG 562

Query: 462 VAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLG-AG 520
            A  VG     G+    G+    G     GP G + AA     + ++         G  G
Sbjct: 563 PAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKG 622

Query: 521 IPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGAL 580
            PG+   VG  G    +G+PG    AG+PG           K  K    + G +G  G  
Sbjct: 623 EPGVVGAVGTAGPSGPSGLPGERGAAGIPG----------GKGEKGEPGLRGEIGNPGRD 672

Query: 581 GGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPA 640
           G  G PG V   GPA A      A  A   G  G  G  G   G +G  G  G  G   A
Sbjct: 673 GARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPG-ERGEVGPAGPNGFAGPAGA 731

Query: 641 AAAKAAK 647
           A    AK
Sbjct: 732 AGQPGAK 738



 Score =  151 bits (382), Expect = 2e-36
 Identities = 214/666 (32%), Positives = 250/666 (37%), Gaps = 86/666 (12%)

Query: 26   PGGVPGAIPGGV-PGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPG 84
            P G+PG+ PG + P G   P +G  G   +P P G AGA    G   FP    P    PG
Sbjct: 449  PRGLPGS-PGNIGPAGKEGP-VGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTG-DPG 505

Query: 85   GVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGV 144
               D        K  AGL G  G  G   + GA  P    GV+ GK    G PG      
Sbjct: 506  KNGD--------KGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQ-GPPGPPGFQG 556

Query: 145  LPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPG-VGPFGGPQPGVPLGYPIKAPKL 203
            LPG         P  P G   KP   G+ G F G+PG  GP G   P             
Sbjct: 557  LPG---------PSGPAGEVGKPGERGLHGEF-GLPGPAGPRGERGP------------- 593

Query: 204  PGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGV 263
            PG  G    TG +    GP G  G  G  G P    VG    A  +  +      GAAG+
Sbjct: 594  PGESGAAGPTGPIG-SRGPSGPPGPDGNKGEPGV--VGAVGTAGPSGPSGLPGERGAAGI 650

Query: 264  LPGVGGAGVPGVPGAI--PGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFG 320
              G G  G PG+ G I  PG  G  G  G   A   A A     + GAA    P GP   
Sbjct: 651  PGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGS 710

Query: 321  PGVVGVPGAGVPGVGVPGAGIPVVPGA-GIPGAAVP----GVVSPEAAAKAAAKAAKYGA 375
            PG  G  G   P      AG    PGA G  GA  P    GVV P     AA  A   G 
Sbjct: 711  PGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGP 770

Query: 376  RPGV----GVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEA 431
             PG     G GG P    G  GFPG   G  G PG +G+ G  G PG  G  G+   P  
Sbjct: 771  -PGPAGSRGDGGPP----GMTGFPG-AAGRTGPPGPSGISGPPGPPGPAGKEGLR-GPRG 823

Query: 432  QAAAAAKAAKYGLV--PGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPG------ 483
                  +  + G V  PG     G     G    PG     G+  APG+   PG      
Sbjct: 824  DQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERG 883

Query: 484  -VGVAPGIG-PGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPG 541
              GVA  +G PG +  A    A+    A    + G+  G PG     G PG     G PG
Sbjct: 884  LPGVAGAVGEPGPLGIAGPPGARGPPGAV--GSPGVN-GAPGEAGRDGNPG---NDGPPG 937

Query: 542  LGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAA 601
                 G  G    PG +    A    A  PG  G +G  G  G  G    +GP   A A 
Sbjct: 938  RDGQPGHKGERGYPGNIGPVGA----AGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAV 993

Query: 602  KAAAKAAQFGLVGAAG-LGGLGVGGL-GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLS 659
                 +   G+ G  G  G  G  GL G+ G  GL G+P      A  +G    PG  + 
Sbjct: 994  GPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLP----GIAGHHGDQGAPG-SVG 1048

Query: 660  PIFPGG 665
            P  P G
Sbjct: 1049 PAGPRG 1054



 Score =  148 bits (374), Expect = 1e-35
 Identities = 210/663 (31%), Positives = 247/663 (37%), Gaps = 103/663 (15%)

Query: 34  PGGVPG--GVFYPALGPGGKPLKPVPGGLAGA------GLGAGLGAFPAVTFPGALVPGG 85
           P G PG  G   P  GP G P  P P GL G       G G GLG  P     G + P G
Sbjct: 46  PPGPPGRDGEDGPT-GPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPM----GLMGPRG 100

Query: 86  VADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVL 145
              AA A    +   G  G PG  G    AGA  P   AG  PGK    G PG  PG   
Sbjct: 101 PPGAAGA-PGPQGFQGPAGEPGEPGQTGPAGARGP---AG-PPGKAGEDGHPGK-PGR-- 152

Query: 146 PGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGG--PQPGVPLGYPIKA-PK 202
           PG R    GV+   P GA   P  PG+ G F GI G     G   QPG P    +K  P 
Sbjct: 153 PGER----GVVG--PQGARGFPGTPGLPG-FKGIRGHNGLDGLKGQPGAP---GVKGEPG 202

Query: 203 LPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAG 262
            PG  G P  TG         G+ G  G+ G P     GP  A  +          G  G
Sbjct: 203 APGENGTPGQTGAR-------GLPGERGRVGAP-----GPAGARGSDGSV------GPVG 244

Query: 263 VLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPG 322
               +G AG PG PGA    G I  VG    A  A    +    G +    P GP   PG
Sbjct: 245 PAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSG---PVGPPGNPG 301

Query: 323 VVGVPG----AGVPGVGVPGAGIPVVPG-AGIPG-------AAVPGVVSPEAAAKAAAKA 370
             G+ G    AG+PGV    AG P +PG  GIPG           G+V     A +  ++
Sbjct: 302 ANGLTGAKGAAGLPGV----AGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGES 357

Query: 371 AKYGARPGVGVGGIPTYG-----VGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGV 425
              G     G  G P         G  G  G   G  G PG+ G PG  G+PG  G  GV
Sbjct: 358 GNKGEPGSAGPQGPPGPSGEEGKRGPNGEAG-SAGPPGPPGLRGSPGSRGLPGADGRAGV 416

Query: 426 GISPEAQAAA-----------AAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGV 474
              P ++ A+           A +  + GL+   G+    G     G    VGL PG+  
Sbjct: 417 MGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGL-PGIDG 475

Query: 475 APG-VGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGA-GIPGLGVGVGVPG 532
            PG +G A   G    IG  G         K   K     A   GA G  G     G PG
Sbjct: 476 RPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPG 535

Query: 533 LGVGAGVPGLGVGAGVPGFGAVPGALA-AAKAAKYGA-------AVPGVLGGLGALGGVG 584
                G  G     G PGF  +PG    A +  K G         +PG  G  G  G  G
Sbjct: 536 PQGVQGGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPG 595

Query: 585 IPGGVVGAGPAAAAAAAKAA---AKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAA 641
             G     GP  +   +          + G+VGA G  G   G  G+PG  G  GIP   
Sbjct: 596 ESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPS-GPSGLPGERGAAGIPGGK 654

Query: 642 AAK 644
             K
Sbjct: 655 GEK 657



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 90/289 (31%), Positives = 106/289 (36%), Gaps = 26/289 (8%)

Query: 400 GVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPG 459
           G  G  G  G PG  G  G  G PG    P         AA+Y    GVG+ PG     G
Sbjct: 39  GPRGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYD-GKGVGLGPGPMGLMG 97

Query: 460 VGVAPGVGLAPGVGVAPGVGVAPG----VGVAPGIGPGGVAAAAKS---AAKVAAKAQLR 512
               PG   APG     G    PG     G A   GP G    A       K     +  
Sbjct: 98  PRGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERG 157

Query: 513 AAAGLGA----GIPGLG--VGV----GVPGLGVGAGVPGLGVGAGVPGFGAVPGALAA-- 560
                GA    G PGL    G+    G+ GL    G PG+    G PG    PG   A  
Sbjct: 158 VVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARG 217

Query: 561 --AKAAKYGAAVP-GVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAG 617
              +  + GA  P G  G  G++G VG  G +  AGP     A     +    G  G AG
Sbjct: 218 LPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAG 277

Query: 618 LGGLGVGGLGVPGVGGLGGIP--PAAAAKAAKYGVAARPGFGLSPIFPG 664
             G   G +G+PG+ G  G P  P A       G A  PG   +P  PG
Sbjct: 278 PAG-PRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPG 325


>gi|32964830 collagen, type VIII, alpha 2 [Homo sapiens]
          Length = 703

 Score =  150 bits (380), Expect = 3e-36
 Identities = 208/676 (30%), Positives = 245/676 (36%), Gaps = 158/676 (23%)

Query: 4   LTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGA 63
           L    P   +LLLLL ++    P    G   GG  G  + P      K ++P+  G  G 
Sbjct: 2   LGTLTPLSSLLLLLLVLVLGCGPRASSGGGAGGAAG--YAPV-----KYIQPMQKGPVGP 54

Query: 64  GLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPG 123
               G G +  +  P  L+P  +          K   G  G PG  G           PG
Sbjct: 55  PFREGKGQYLEMPLP--LLPMDL----------KGEPGPPGKPGPRG----------PPG 92

Query: 124 AGVKPGKVPGVGLPGVY----PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGI 179
               PGK PG+G PG++    P G  PG    G    PG+P   G  P  PG+ G   GI
Sbjct: 93  PPGFPGK-PGMGKPGLHGQPGPAGP-PGFSRMGKAGPPGLPGKVG-PPGQPGLRGE-PGI 148

Query: 180 PGVGPFGGPQ--PGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTG 237
            G     GP   PG+P    I  P  PG  G+P          GP G  G  G  G P  
Sbjct: 149 RGDQGLRGPPGPPGLPGPSGITIPGKPGAQGVP----------GPPGFQGEPGPQGEP-- 196

Query: 238 TGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAA 297
              GP              G G  G LPG  G G  G PG  PG+ G AG+G P      
Sbjct: 197 ---GPPGDRGLKGDN----GVGQPG-LPGAPGQG--GAPGP-PGLPGPAGLGKPGLDGLP 245

Query: 298 AAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA-GVPGVGVPGAGIPVVPGAGIPGAAVPG 356
            A     + G     VPG  G  PG VG  G  GV GVGVPGA       AG+PG   P 
Sbjct: 246 GAPGDKGESGPPG--VPGPRG-EPGAVGPKGPPGVDGVGVPGA-------AGLPGPQGPS 295

Query: 357 VVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGV 416
                            GA+   G  G P   +G  G+     G+ G+PG  G  G  GV
Sbjct: 296 -----------------GAKGEPGTRGPPGL-IGPTGY-----GMPGLPGPKGDRGPAGV 332

Query: 417 PGV---GGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVG 473
           PG+    G PG    P  Q              G+G  PG+   PG    PG    PG  
Sbjct: 333 PGLLGDRGEPGEDGEPGEQGPQ-----------GLGGPPGL---PGSAGLPGRRGPPGPK 378

Query: 474 VAPGVGVAPGV-GVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPG 532
              G G  PGV G+    GP G+A                       G PG+    G+PG
Sbjct: 379 GEAGPGGPPGVPGIRGDQGPSGLA-----------------------GKPGVPGERGLPG 415

Query: 533 LGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGA 592
                G PG     G PGF   PG              PGV G LG  G +G+PG     
Sbjct: 416 ---AHGPPGPTGPKGEPGFTGRPGG-------------PGVAGALGQKGDLGLPGQPGLR 459

Query: 593 GPAAAAAAAKAAAKAAQFGLVGAAGLGGL----GVGGLGVPGVGGLGGIPPAAAAKAAKY 648
           GP+        A      GL G  G  GL    G G  G PG  G  G PP         
Sbjct: 460 GPSGIPGLQGPAGPIGPQGLPGLKGEPGLPGPPGEGRAGEPGTAGPTG-PPGVPGSPGIT 518

Query: 649 GVAARPGFGLSPIFPG 664
           G    PG    P  PG
Sbjct: 519 GPPGPPGPPGPPGAPG 534



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 85/260 (32%), Positives = 104/260 (40%), Gaps = 38/260 (14%)

Query: 23  PSRPGGVPGAIPG--GVPGGVFYPA----LGPGGKPLKPVPGGLAGAGLGAGLGAFPAVT 76
           P   GG PG +PG  G+PG    P      GPGG P  P   G+ G    +GL   P V 
Sbjct: 353 PQGLGGPPG-LPGSAGLPGRRGPPGPKGEAGPGGPPGVP---GIRGDQGPSGLAGKPGVP 408

Query: 77  ----FPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGV--KPGK 130
                PGA  P G           K   G  G PG  G+   AGA+  +   G+  +PG 
Sbjct: 409 GERGLPGAHGPPGPT-------GPKGEPGFTGRPGGPGV---AGALGQKGDLGLPGQPGL 458

Query: 131 VPGVGLPGVY-PGGVLPGARFPGVGVLPGVPTGAGV-KPKAPGVGGAFA--GIPGVGPFG 186
               G+PG+  P G +     PG+   PG+P   G  +   PG  G     G+PG     
Sbjct: 459 RGPSGIPGLQGPAGPIGPQGLPGLKGEPGLPGPPGEGRAGEPGTAGPTGPPGVPGSPGIT 518

Query: 187 GPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAA-GKAGYPTGTGVGPQAA 245
           GP PG P       P  PG  G    TG        GGV GA  GK G P   G+G  +A
Sbjct: 519 GP-PGPP-----GPPGPPGAPGAFDETGIAGLHLPNGGVEGAVLGKGGKPQ-FGLGELSA 571

Query: 246 AAAAAKAAAKFGAGAAGVLP 265
            A  A  A       A  +P
Sbjct: 572 HATPAFTAVLTSPFPASGMP 591


>gi|32895368 alpha 1 type VIII collagen precursor [Homo sapiens]
          Length = 744

 Score =  149 bits (375), Expect = 1e-35
 Identities = 165/503 (32%), Positives = 199/503 (39%), Gaps = 79/503 (15%)

Query: 121 QPGAGVKPGK--VPGVGLPGVY----PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGG 174
           +PG    PG   +PG G+PG+     P G  PG   PG+  +PG P   G+    PG  G
Sbjct: 125 EPGPRGPPGPPGLPGHGIPGIKGKPGPQGY-PGVGKPGMPGMPGKPGAMGM----PGAKG 179

Query: 175 AFAGIPGVGPFGGPQPGVPLGYPIKAPKL--PGGYGLPYTTGKLPYG-YGPGGVAGAAGK 231
                  +GP G P P  P G P   P +  PGG GLP   G  P G  GP G+ G  G 
Sbjct: 180 EIGQKGEIGPMGIPGPQGPPG-PHGLPGIGKPGGPGLPGQPG--PKGDRGPKGLPGPQGL 236

Query: 232 AGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTP 291
            G     G G   A                   PGV G   PG+ G  PG  G+ GVG P
Sbjct: 237 RGPKGDKGFGMPGA-------------------PGVKGP--PGMHGP-PGPVGLPGVGKP 274

Query: 292 AAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGA-GIPVVPG--AG 348
                        K GA     P GP   PGV G P  G+PG+G PG  GIP  PG   G
Sbjct: 275 GVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPP--GIPGIGKPGQDGIPGQPGFPGG 332

Query: 349 IPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGI--PTYGVGAGGFPGFGVGVGGIPG 406
                +PG+  P                PG+G  G   P    G GG PG  +G  G  G
Sbjct: 333 KGEQGLPGLPGPPGL-------------PGIGKPGFPGPKGDRGMGGVPG-ALGPRGEKG 378

Query: 407 VAGVPGVGGVPGVGGVPGV--GISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAP 464
             G PG+GG PG  G+PG+   + P           + G+V   G  PG    PG+   P
Sbjct: 379 PIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQG-PPGPKGEPGLQGFP 437

Query: 465 GVGLAPGVGVAPGVGVAPG-VGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLG----A 519
           G     G    PG+   PG +G     G  GV         +  K +       G     
Sbjct: 438 GKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPP 497

Query: 520 GIPGLG---VGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGG 576
           GIPG+G     +G PG+    G PGL    G PG G  PG      A  +G   PG  G 
Sbjct: 498 GIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGK-PGV-----AGLHGP--PGKPGA 549

Query: 577 LGALGGVGIPGGVVGAGPAAAAA 599
           LG  G  G+PG     GP    A
Sbjct: 550 LGPQGQPGLPGPPGPPGPPGPPA 572



 Score =  142 bits (358), Expect = 1e-33
 Identities = 177/543 (32%), Positives = 215/543 (39%), Gaps = 96/543 (17%)

Query: 7   AAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLG 66
           A P+ G  + L S+     P G PG  P G PG    P  G  G   KP P G  G G  
Sbjct: 103 AVPKKGKEIPLASLRGEQGPRGEPG--PRGPPGPPGLPGHGIPGIKGKPGPQGYPGVG-K 159

Query: 67  AGLGAFPAVTFPGAL-VPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAG 125
            G+   P    PGA+ +PG   +        K   G  G+PG  G           PG  
Sbjct: 160 PGMPGMPGK--PGAMGMPGAKGEI-----GQKGEIGPMGIPGPQG----------PPG-- 200

Query: 126 VKPGKVPGVGLPGVYPGGVLPGARFP-GVGVLPGVPTGAGVKPKAPGVGGAFAGIPGV-G 183
             P  +PG+G PG   G  LPG   P G     G+P   G++      G    G PGV G
Sbjct: 201 --PHGLPGIGKPG---GPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKG 255

Query: 184 PFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQ 243
           P G   P  P+G P        G G P  TG  P   GP G  GA G+ G P G    P 
Sbjct: 256 PPGMHGPPGPVGLP--------GVGKPGVTG-FPGPQGPLGKPGAPGEPG-PQGPIGVPG 305

Query: 244 AAAAAAAKAAAKFGAGAAGVLPGV-GGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAK 302
                      K G       PG  GG G  G+PG +PG  G+ G+G P           
Sbjct: 306 VQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPG-LPGPPGLPGIGKP--------GFP 356

Query: 303 AAKYGAAAGLVPG--GPGFGPGVVGVPGAGVPGVGVPG-AGIPVVPG-AGIPGAAVPGVV 358
             K     G VPG  GP    G +G PG G    G PG  G+P +PG  G PGA   G  
Sbjct: 357 GPKGDRGMGGVPGALGPRGEKGPIGAPGIG----GPPGEPGLPGIPGPMGPPGAI--GFP 410

Query: 359 SPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPG-VG--- 414
            P+            G +   G+ G P       G PGF +G  G PG+ G+PG +G   
Sbjct: 411 GPKGEGGIVGPQGPPGPKGEPGLQGFP-------GKPGF-LGEVGPPGMRGLPGPIGPKG 462

Query: 415 -----GVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLA 469
                GVPG+ GVPG+ + P+ +          G  PG+   PG+G   G    PG+   
Sbjct: 463 EAGQKGVPGLPGVPGL-LGPKGEPGIPGDQGLQG-PPGI---PGIGGPSGPIGPPGI--- 514

Query: 470 PGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVG 529
           PG    PG+   PG    PGIG  GVA       K  A            G PGL    G
Sbjct: 515 PGPKGEPGLPGPPGF---PGIGKPGVAGLHGPPGKPGALGP--------QGQPGLPGPPG 563

Query: 530 VPG 532
            PG
Sbjct: 564 PPG 566



 Score =  133 bits (335), Expect = 5e-31
 Identities = 173/485 (35%), Positives = 208/485 (42%), Gaps = 80/485 (16%)

Query: 23  PSRPGGVPG-AIPG--GVPGGVFYPALG-PG--GKPLKPVPGGLAGAGLGAGL-GAFPAV 75
           P  P G+PG  IPG  G PG   YP +G PG  G P KP   G+ GA    G  G    +
Sbjct: 131 PPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPM 190

Query: 76  TFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGK----- 130
             PG   P G        K    G GL G PG  G     G   PQ   G K  K     
Sbjct: 191 GIPGPQGPPGPHGLPGIGKPG--GPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMP 248

Query: 131 -VPGV-GLPGVY--PGGV-LPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFA--GIPGVG 183
             PGV G PG++  PG V LPG   PGV   PG P G   KP APG  G     G+PGV 
Sbjct: 249 GAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPG-PQGPLGKPGAPGEPGPQGPIGVPGVQ 307

Query: 184 PFGGPQPGVP-LGYPIKAPKLPGGYGLPYTTGK--LPYGYGPGGVAGAAGKAGYPTGTGV 240
              GP PG+P +G P +   +PG  G P   G+  LP   GP G+ G  GK G+P     
Sbjct: 308 ---GP-PGIPGIGKPGQ-DGIPGQPGFPGGKGEQGLPGLPGPPGLPGI-GKPGFP----- 356

Query: 241 GPQAAAAAAAKAAAKFGAGAAGVL--PGVGGA-GVPGVPGAIPGIGGIAG-VGTPAAAAA 296
           GP+          A    G  G +  PG+GG  G PG+PG IPG  G  G +G P     
Sbjct: 357 GPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPG-IPGPMGPPGAIGFPGPKGE 415

Query: 297 AAAAAKAAKYGAAA--GL--VPGGPGFGPGVVGVPGA-GVPG-VGVPG-AGIPVVPGAGI 349
                     G     GL   PG PGF  G VG PG  G+PG +G  G AG   VPG  +
Sbjct: 416 GGIVGPQGPPGPKGEPGLQGFPGKPGF-LGEVGPPGMRGLPGPIGPKGEAGQKGVPG--L 472

Query: 350 PGAAVPGVVSPEAAAKAAAKAAKYGARPGV-GVGGIPTYGVGAGGFPGFGVGVGGIPGVA 408
           PG  VPG++ P+            G  PG+ G+GG P+  +G  G PG   G  G+PG  
Sbjct: 473 PG--VPGLLGPKGEPGIPGDQGLQGP-PGIPGIGG-PSGPIGPPGIPG-PKGEPGLPGPP 527

Query: 409 GVPGVG-----------------------GVPGVGGVPGVGISPEAQAAAAAKAAKYGLV 445
           G PG+G                       G+PG  G PG    P           +Y   
Sbjct: 528 GFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPD 587

Query: 446 PGVGV 450
            G+G+
Sbjct: 588 MGLGI 592



 Score =  133 bits (334), Expect = 6e-31
 Identities = 174/523 (33%), Positives = 202/523 (38%), Gaps = 100/523 (19%)

Query: 142 GGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYP-IKA 200
           G  +P A   G     G P   G  P  PG+ G   GIPG+    GPQ     GYP +  
Sbjct: 108 GKEIPLASLRGEQGPRGEPGPRG-PPGPPGLPGH--GIPGIKGKPGPQ-----GYPGVGK 159

Query: 201 PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGA 260
           P +PG  G P   G +P   G  G  G  G  G P     GPQ             G   
Sbjct: 160 PGMPGMPGKPGAMG-MPGAKGEIGQKGEIGPMGIP-----GPQ-------------GPPG 200

Query: 261 AGVLPGVGGAGVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGF 319
              LPG+G  G PG+PG  PG  G  G  G P                  A  V G PG 
Sbjct: 201 PHGLPGIGKPGGPGLPGQ-PGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGM 259

Query: 320 G--PGVVGVPGAGVPGV-GVPGAGIPVVPGAGIPGAAVPGVVSPEAAAKAAAKAAKYGAR 376
              PG VG+PG G PGV G PG   P+    G PGA  PG   P+            G  
Sbjct: 260 HGPPGPVGLPGVGKPGVTGFPGPQGPL----GKPGA--PGEPGPQGPIGVPGVQGPPGI- 312

Query: 377 PGVGV---GGIPTYGVGAGGFPGFG--VGVGGIPGVAGVPGVG--GVPGVGGVPGVGISP 429
           PG+G     GIP    G  GFPG     G+ G+PG  G+PG+G  G PG  G  G+G  P
Sbjct: 313 PGIGKPGQDGIP----GQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVP 368

Query: 430 EAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG 489
            A      K         +G APG+G  PG    PG+   PG    PG    PG     G
Sbjct: 369 GALGPRGEKGP-------IG-APGIGGPPGEPGLPGI---PGPMGPPGAIGFPGPKGEGG 417

Query: 490 I-GPGGVAAAAKSAAKVAAKAQLRAAAGLGA--GIPGLGVGVGVPGLGVGAGVPGLGVGA 546
           I GP G                 +   GL    G PG    VG PG+    G+PG  +G 
Sbjct: 418 IVGPQGPPGP-------------KGEPGLQGFPGKPGFLGEVGPPGM---RGLPG-PIGP 460

Query: 547 -------GVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAA 599
                  GVPG   VPG L            PG+ G  G  G  GIPG    +GP     
Sbjct: 461 KGEAGQKGVPGLPGVPGLLGPK-------GEPGIPGDQGLQGPPGIPGIGGPSGPIGPPG 513

Query: 600 AAKAAAKAAQFGLVGAAGLGGLGVGGL----GVPGVGGLGGIP 638
                 +    G  G  G+G  GV GL    G PG  G  G P
Sbjct: 514 IPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQP 556



 Score =  124 bits (310), Expect = 4e-28
 Identities = 163/540 (30%), Positives = 198/540 (36%), Gaps = 109/540 (20%)

Query: 164 GVKPKAPGVGGAFAG-IPGVGPFGGPQPGVPLGYPIKA-----PKLPGGYGLPYTTGKLP 217
           G+KP  P +       IP   P G   P +PL     A     P L  G   P+    LP
Sbjct: 32  GIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAMGKEMPHLQYGKEYPH----LP 87

Query: 218 YGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPG 277
                   A   GK   P      P A+         + G       PG+ G G+PG+ G
Sbjct: 88  QYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKG 147

Query: 278 AIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA----GVPG 333
             PG  G  GVG P                     +PG PG  PG +G+PGA    G  G
Sbjct: 148 K-PGPQGYPGVGKPG--------------------MPGMPG-KPGAMGMPGAKGEIGQKG 185

Query: 334 ----VGVPGAGIPVVPGAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGV 389
               +G+PG   P  P  G+PG   PG   P    +   K    G R   G+ G P    
Sbjct: 186 EIGPMGIPGPQGPPGPH-GLPGIGKPG--GPGLPGQPGPK----GDRGPKGLPG-PQGLR 237

Query: 390 GAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVG 449
           G  G  GFG+   G PGV G PG+ G PG  G+PGVG                   PGV 
Sbjct: 238 GPKGDKGFGMP--GAPGVKGPPGMHGPPGPVGLPGVG------------------KPGVT 277

Query: 450 VAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKA 509
             PG     G   APG     G    PGV   PG+   PGIG  G             K 
Sbjct: 278 GFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGI---PGIGKPGQDGIPGQPGFPGGKG 334

Query: 510 QLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALA-AAKAAKYGA 568
           +         G+PGL    G+PG+    G PG     G  G G VPGAL    +    GA
Sbjct: 335 E--------QGLPGLPGPPGLPGI----GKPGFPGPKGDRGMGGVPGALGPRGEKGPIGA 382

Query: 569 ----------AVPGVLGGLGALGGVGIP-----GGVVG----AGPAAAAAAAKAAAKAAQ 609
                      +PG+ G +G  G +G P     GG+VG     GP           K   
Sbjct: 383 PGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGF 442

Query: 610 FGLVGAAGLGGL-----GVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
            G VG  G+ GL       G  G  GV GL G+P     K  + G+    G    P  PG
Sbjct: 443 LGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPK-GEPGIPGDQGLQGPPGIPG 501



 Score =  103 bits (258), Expect = 4e-22
 Identities = 130/397 (32%), Positives = 154/397 (38%), Gaps = 69/397 (17%)

Query: 23  PSRPGGVPGAIPGGVPGGVFYPA----LGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFP 78
           P  P G+PG    G PG   +P     LG  G P +P P G  G     G    P +  P
Sbjct: 262 PPGPVGLPGV---GKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKP 318

Query: 79  GAL-VPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLP 137
           G   +PG        +   K   GL G+PG  GL        P P      G VPG   P
Sbjct: 319 GQDGIPG-----QPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGP 373

Query: 138 GVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPG-------VGPFGGPQP 190
               G +  GA  PG+G  PG P   G+ P   G  GA  G PG       VGP G P P
Sbjct: 374 RGEKGPI--GA--PGIGGPPGEPGLPGI-PGPMGPPGAI-GFPGPKGEGGIVGPQGPPGP 427

Query: 191 -GVP--LGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAA 246
            G P   G+P K P   G  G P   G LP   GP G AG  G  G P   G+ GP+   
Sbjct: 428 KGEPGLQGFPGK-PGFLGEVGPPGMRG-LPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEP 485

Query: 247 AAAAKAAAKFGAGAAGVLPGVGGAGVPGVPG-----AIPGIGGIAGVGTPAAAAAAAAAA 301
                   +   G  G+    G  G PG+PG      +PG  G  G+G P  A       
Sbjct: 486 GIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPG 545

Query: 302 KAAKYGAAAGLVPG--GPGFGPGVVGVPGAGVPGVGVPGAGIPVVP---GAGIP--GAAV 354
           K           PG  GP   PG+ G PG   PG   P A +P  P   G  +P  G  +
Sbjct: 546 K-----------PGALGPQGQPGLPGPPGP--PGPPGPPAVMPPTPPPQGEYLPDMGLGI 592

Query: 355 PGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGA 391
            GV  P A          YGA+ G   G  P Y + A
Sbjct: 593 DGVKPPHA----------YGAKKGKNGG--PAYEMPA 617


>gi|17738302 alpha 1 type VIII collagen precursor [Homo sapiens]
          Length = 744

 Score =  149 bits (375), Expect = 1e-35
 Identities = 165/503 (32%), Positives = 199/503 (39%), Gaps = 79/503 (15%)

Query: 121 QPGAGVKPGK--VPGVGLPGVY----PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGG 174
           +PG    PG   +PG G+PG+     P G  PG   PG+  +PG P   G+    PG  G
Sbjct: 125 EPGPRGPPGPPGLPGHGIPGIKGKPGPQGY-PGVGKPGMPGMPGKPGAMGM----PGAKG 179

Query: 175 AFAGIPGVGPFGGPQPGVPLGYPIKAPKL--PGGYGLPYTTGKLPYG-YGPGGVAGAAGK 231
                  +GP G P P  P G P   P +  PGG GLP   G  P G  GP G+ G  G 
Sbjct: 180 EIGQKGEIGPMGIPGPQGPPG-PHGLPGIGKPGGPGLPGQPG--PKGDRGPKGLPGPQGL 236

Query: 232 AGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTP 291
            G     G G   A                   PGV G   PG+ G  PG  G+ GVG P
Sbjct: 237 RGPKGDKGFGMPGA-------------------PGVKGP--PGMHGP-PGPVGLPGVGKP 274

Query: 292 AAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGA-GIPVVPG--AG 348
                        K GA     P GP   PGV G P  G+PG+G PG  GIP  PG   G
Sbjct: 275 GVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPP--GIPGIGKPGQDGIPGQPGFPGG 332

Query: 349 IPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGI--PTYGVGAGGFPGFGVGVGGIPG 406
                +PG+  P                PG+G  G   P    G GG PG  +G  G  G
Sbjct: 333 KGEQGLPGLPGPPGL-------------PGIGKPGFPGPKGDRGMGGVPG-ALGPRGEKG 378

Query: 407 VAGVPGVGGVPGVGGVPGV--GISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAP 464
             G PG+GG PG  G+PG+   + P           + G+V   G  PG    PG+   P
Sbjct: 379 PIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQG-PPGPKGEPGLQGFP 437

Query: 465 GVGLAPGVGVAPGVGVAPG-VGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLG----A 519
           G     G    PG+   PG +G     G  GV         +  K +       G     
Sbjct: 438 GKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPP 497

Query: 520 GIPGLG---VGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGG 576
           GIPG+G     +G PG+    G PGL    G PG G  PG      A  +G   PG  G 
Sbjct: 498 GIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGK-PGV-----AGLHGP--PGKPGA 549

Query: 577 LGALGGVGIPGGVVGAGPAAAAA 599
           LG  G  G+PG     GP    A
Sbjct: 550 LGPQGQPGLPGPPGPPGPPGPPA 572



 Score =  142 bits (358), Expect = 1e-33
 Identities = 177/543 (32%), Positives = 215/543 (39%), Gaps = 96/543 (17%)

Query: 7   AAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLG 66
           A P+ G  + L S+     P G PG  P G PG    P  G  G   KP P G  G G  
Sbjct: 103 AVPKKGKEIPLASLRGEQGPRGEPG--PRGPPGPPGLPGHGIPGIKGKPGPQGYPGVG-K 159

Query: 67  AGLGAFPAVTFPGAL-VPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAG 125
            G+   P    PGA+ +PG   +        K   G  G+PG  G           PG  
Sbjct: 160 PGMPGMPGK--PGAMGMPGAKGEI-----GQKGEIGPMGIPGPQG----------PPG-- 200

Query: 126 VKPGKVPGVGLPGVYPGGVLPGARFP-GVGVLPGVPTGAGVKPKAPGVGGAFAGIPGV-G 183
             P  +PG+G PG   G  LPG   P G     G+P   G++      G    G PGV G
Sbjct: 201 --PHGLPGIGKPG---GPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKG 255

Query: 184 PFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQ 243
           P G   P  P+G P        G G P  TG  P   GP G  GA G+ G P G    P 
Sbjct: 256 PPGMHGPPGPVGLP--------GVGKPGVTG-FPGPQGPLGKPGAPGEPG-PQGPIGVPG 305

Query: 244 AAAAAAAKAAAKFGAGAAGVLPGV-GGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAK 302
                      K G       PG  GG G  G+PG +PG  G+ G+G P           
Sbjct: 306 VQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPG-LPGPPGLPGIGKP--------GFP 356

Query: 303 AAKYGAAAGLVPG--GPGFGPGVVGVPGAGVPGVGVPG-AGIPVVPG-AGIPGAAVPGVV 358
             K     G VPG  GP    G +G PG G    G PG  G+P +PG  G PGA   G  
Sbjct: 357 GPKGDRGMGGVPGALGPRGEKGPIGAPGIG----GPPGEPGLPGIPGPMGPPGAI--GFP 410

Query: 359 SPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPG-VG--- 414
            P+            G +   G+ G P       G PGF +G  G PG+ G+PG +G   
Sbjct: 411 GPKGEGGIVGPQGPPGPKGEPGLQGFP-------GKPGF-LGEVGPPGMRGLPGPIGPKG 462

Query: 415 -----GVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLA 469
                GVPG+ GVPG+ + P+ +          G  PG+   PG+G   G    PG+   
Sbjct: 463 EAGQKGVPGLPGVPGL-LGPKGEPGIPGDQGLQG-PPGI---PGIGGPSGPIGPPGI--- 514

Query: 470 PGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVG 529
           PG    PG+   PG    PGIG  GVA       K  A            G PGL    G
Sbjct: 515 PGPKGEPGLPGPPGF---PGIGKPGVAGLHGPPGKPGALGP--------QGQPGLPGPPG 563

Query: 530 VPG 532
            PG
Sbjct: 564 PPG 566



 Score =  133 bits (335), Expect = 5e-31
 Identities = 173/485 (35%), Positives = 208/485 (42%), Gaps = 80/485 (16%)

Query: 23  PSRPGGVPG-AIPG--GVPGGVFYPALG-PG--GKPLKPVPGGLAGAGLGAGL-GAFPAV 75
           P  P G+PG  IPG  G PG   YP +G PG  G P KP   G+ GA    G  G    +
Sbjct: 131 PPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPM 190

Query: 76  TFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGK----- 130
             PG   P G        K    G GL G PG  G     G   PQ   G K  K     
Sbjct: 191 GIPGPQGPPGPHGLPGIGKPG--GPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMP 248

Query: 131 -VPGV-GLPGVY--PGGV-LPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFA--GIPGVG 183
             PGV G PG++  PG V LPG   PGV   PG P G   KP APG  G     G+PGV 
Sbjct: 249 GAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPG-PQGPLGKPGAPGEPGPQGPIGVPGVQ 307

Query: 184 PFGGPQPGVP-LGYPIKAPKLPGGYGLPYTTGK--LPYGYGPGGVAGAAGKAGYPTGTGV 240
              GP PG+P +G P +   +PG  G P   G+  LP   GP G+ G  GK G+P     
Sbjct: 308 ---GP-PGIPGIGKPGQ-DGIPGQPGFPGGKGEQGLPGLPGPPGLPGI-GKPGFP----- 356

Query: 241 GPQAAAAAAAKAAAKFGAGAAGVL--PGVGGA-GVPGVPGAIPGIGGIAG-VGTPAAAAA 296
           GP+          A    G  G +  PG+GG  G PG+PG IPG  G  G +G P     
Sbjct: 357 GPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPG-IPGPMGPPGAIGFPGPKGE 415

Query: 297 AAAAAKAAKYGAAA--GL--VPGGPGFGPGVVGVPGA-GVPG-VGVPG-AGIPVVPGAGI 349
                     G     GL   PG PGF  G VG PG  G+PG +G  G AG   VPG  +
Sbjct: 416 GGIVGPQGPPGPKGEPGLQGFPGKPGF-LGEVGPPGMRGLPGPIGPKGEAGQKGVPG--L 472

Query: 350 PGAAVPGVVSPEAAAKAAAKAAKYGARPGV-GVGGIPTYGVGAGGFPGFGVGVGGIPGVA 408
           PG  VPG++ P+            G  PG+ G+GG P+  +G  G PG   G  G+PG  
Sbjct: 473 PG--VPGLLGPKGEPGIPGDQGLQGP-PGIPGIGG-PSGPIGPPGIPG-PKGEPGLPGPP 527

Query: 409 GVPGVG-----------------------GVPGVGGVPGVGISPEAQAAAAAKAAKYGLV 445
           G PG+G                       G+PG  G PG    P           +Y   
Sbjct: 528 GFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPD 587

Query: 446 PGVGV 450
            G+G+
Sbjct: 588 MGLGI 592



 Score =  133 bits (334), Expect = 6e-31
 Identities = 174/523 (33%), Positives = 202/523 (38%), Gaps = 100/523 (19%)

Query: 142 GGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYP-IKA 200
           G  +P A   G     G P   G  P  PG+ G   GIPG+    GPQ     GYP +  
Sbjct: 108 GKEIPLASLRGEQGPRGEPGPRG-PPGPPGLPGH--GIPGIKGKPGPQ-----GYPGVGK 159

Query: 201 PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGA 260
           P +PG  G P   G +P   G  G  G  G  G P     GPQ             G   
Sbjct: 160 PGMPGMPGKPGAMG-MPGAKGEIGQKGEIGPMGIP-----GPQ-------------GPPG 200

Query: 261 AGVLPGVGGAGVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGF 319
              LPG+G  G PG+PG  PG  G  G  G P                  A  V G PG 
Sbjct: 201 PHGLPGIGKPGGPGLPGQ-PGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGM 259

Query: 320 G--PGVVGVPGAGVPGV-GVPGAGIPVVPGAGIPGAAVPGVVSPEAAAKAAAKAAKYGAR 376
              PG VG+PG G PGV G PG   P+    G PGA  PG   P+            G  
Sbjct: 260 HGPPGPVGLPGVGKPGVTGFPGPQGPL----GKPGA--PGEPGPQGPIGVPGVQGPPGI- 312

Query: 377 PGVGV---GGIPTYGVGAGGFPGFG--VGVGGIPGVAGVPGVG--GVPGVGGVPGVGISP 429
           PG+G     GIP    G  GFPG     G+ G+PG  G+PG+G  G PG  G  G+G  P
Sbjct: 313 PGIGKPGQDGIP----GQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVP 368

Query: 430 EAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG 489
            A      K         +G APG+G  PG    PG+   PG    PG    PG     G
Sbjct: 369 GALGPRGEKGP-------IG-APGIGGPPGEPGLPGI---PGPMGPPGAIGFPGPKGEGG 417

Query: 490 I-GPGGVAAAAKSAAKVAAKAQLRAAAGLGA--GIPGLGVGVGVPGLGVGAGVPGLGVGA 546
           I GP G                 +   GL    G PG    VG PG+    G+PG  +G 
Sbjct: 418 IVGPQGPPGP-------------KGEPGLQGFPGKPGFLGEVGPPGM---RGLPG-PIGP 460

Query: 547 -------GVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAA 599
                  GVPG   VPG L            PG+ G  G  G  GIPG    +GP     
Sbjct: 461 KGEAGQKGVPGLPGVPGLLGPK-------GEPGIPGDQGLQGPPGIPGIGGPSGPIGPPG 513

Query: 600 AAKAAAKAAQFGLVGAAGLGGLGVGGL----GVPGVGGLGGIP 638
                 +    G  G  G+G  GV GL    G PG  G  G P
Sbjct: 514 IPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQP 556



 Score =  124 bits (310), Expect = 4e-28
 Identities = 163/540 (30%), Positives = 198/540 (36%), Gaps = 109/540 (20%)

Query: 164 GVKPKAPGVGGAFAG-IPGVGPFGGPQPGVPLGYPIKA-----PKLPGGYGLPYTTGKLP 217
           G+KP  P +       IP   P G   P +PL     A     P L  G   P+    LP
Sbjct: 32  GIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAMGKEMPHLQYGKEYPH----LP 87

Query: 218 YGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPG 277
                   A   GK   P      P A+         + G       PG+ G G+PG+ G
Sbjct: 88  QYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKG 147

Query: 278 AIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA----GVPG 333
             PG  G  GVG P                     +PG PG  PG +G+PGA    G  G
Sbjct: 148 K-PGPQGYPGVGKPG--------------------MPGMPG-KPGAMGMPGAKGEIGQKG 185

Query: 334 ----VGVPGAGIPVVPGAGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGV 389
               +G+PG   P  P  G+PG   PG   P    +   K    G R   G+ G P    
Sbjct: 186 EIGPMGIPGPQGPPGPH-GLPGIGKPG--GPGLPGQPGPK----GDRGPKGLPG-PQGLR 237

Query: 390 GAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVG 449
           G  G  GFG+   G PGV G PG+ G PG  G+PGVG                   PGV 
Sbjct: 238 GPKGDKGFGMP--GAPGVKGPPGMHGPPGPVGLPGVG------------------KPGVT 277

Query: 450 VAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKA 509
             PG     G   APG     G    PGV   PG+   PGIG  G             K 
Sbjct: 278 GFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGI---PGIGKPGQDGIPGQPGFPGGKG 334

Query: 510 QLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALA-AAKAAKYGA 568
           +         G+PGL    G+PG+    G PG     G  G G VPGAL    +    GA
Sbjct: 335 E--------QGLPGLPGPPGLPGI----GKPGFPGPKGDRGMGGVPGALGPRGEKGPIGA 382

Query: 569 ----------AVPGVLGGLGALGGVGIP-----GGVVG----AGPAAAAAAAKAAAKAAQ 609
                      +PG+ G +G  G +G P     GG+VG     GP           K   
Sbjct: 383 PGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGF 442

Query: 610 FGLVGAAGLGGL-----GVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
            G VG  G+ GL       G  G  GV GL G+P     K  + G+    G    P  PG
Sbjct: 443 LGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPK-GEPGIPGDQGLQGPPGIPG 501



 Score =  103 bits (258), Expect = 4e-22
 Identities = 130/397 (32%), Positives = 154/397 (38%), Gaps = 69/397 (17%)

Query: 23  PSRPGGVPGAIPGGVPGGVFYPA----LGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFP 78
           P  P G+PG    G PG   +P     LG  G P +P P G  G     G    P +  P
Sbjct: 262 PPGPVGLPGV---GKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKP 318

Query: 79  GAL-VPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLP 137
           G   +PG        +   K   GL G+PG  GL        P P      G VPG   P
Sbjct: 319 GQDGIPG-----QPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGP 373

Query: 138 GVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPG-------VGPFGGPQP 190
               G +  GA  PG+G  PG P   G+ P   G  GA  G PG       VGP G P P
Sbjct: 374 RGEKGPI--GA--PGIGGPPGEPGLPGI-PGPMGPPGAI-GFPGPKGEGGIVGPQGPPGP 427

Query: 191 -GVP--LGYPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAA 246
            G P   G+P K P   G  G P   G LP   GP G AG  G  G P   G+ GP+   
Sbjct: 428 KGEPGLQGFPGK-PGFLGEVGPPGMRG-LPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEP 485

Query: 247 AAAAKAAAKFGAGAAGVLPGVGGAGVPGVPG-----AIPGIGGIAGVGTPAAAAAAAAAA 301
                   +   G  G+    G  G PG+PG      +PG  G  G+G P  A       
Sbjct: 486 GIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPG 545

Query: 302 KAAKYGAAAGLVPG--GPGFGPGVVGVPGAGVPGVGVPGAGIPVVP---GAGIP--GAAV 354
           K           PG  GP   PG+ G PG   PG   P A +P  P   G  +P  G  +
Sbjct: 546 K-----------PGALGPQGQPGLPGPPGP--PGPPGPPAVMPPTPPPQGEYLPDMGLGI 592

Query: 355 PGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGA 391
            GV  P A          YGA+ G   G  P Y + A
Sbjct: 593 DGVKPPHA----------YGAKKGKNGG--PAYEMPA 617


>gi|148536823 type IV alpha 6 collagen isoform A precursor [Homo
            sapiens]
          Length = 1691

 Score =  147 bits (372), Expect = 2e-35
 Identities = 203/693 (29%), Positives = 258/693 (37%), Gaps = 91/693 (13%)

Query: 23   PSRPG--GVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGA-GLGAGLGAFPAVTFPG 79
            P  PG  G PG  P G+PG       GP G P      GL G  GL    G       PG
Sbjct: 604  PGLPGEKGHPG--PPGLPGNGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGITLPCIIPG 661

Query: 80   ALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGV 139
            +  P G       +   K   GL G PG  G   S G    +PG+   PG V    LPG 
Sbjct: 662  SYGPSGFP-GTPGFPGPKGSRGLPGTPGQPGSSGSKG----EPGS---PGLVHLPELPG- 712

Query: 140  YPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIK 199
                  PG R  G   LPG P G   K   PG+ G+  G+PG     G   G   G    
Sbjct: 713  -----FPGPR--GEKGLPGFP-GLPGKDGLPGMIGS-PGLPGSKGATGDIFGAENG---- 759

Query: 200  APKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGA 258
                PG  GL   TG   +  G  G+ G  G  G P   G  G + +     +       
Sbjct: 760  ---APGEQGLQGLTGHKGF-LGDSGLPGLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTP 815

Query: 259  GAAGVLPGVGGAGVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGP 317
            G++G     G +G+PG PG  PGI G  G  GT        +  K    G     +PG P
Sbjct: 816  GSSGPYGIKGKSGLPGAPG-FPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKG--LPGNP 872

Query: 318  GF--------GPGVVGVPGAGVPG--------VGVPGA-GIPVVPGA-GIPGAAVPGVVS 359
            G          PGV G+P    P         VG PG  G+P +PG  G+ G  +PG   
Sbjct: 873  GLVGLKGSPGSPGVAGLPALSGPKGEKGSVGFVGFPGIPGLPGIPGTRGLKG--IPGSTG 930

Query: 360  PEAAAKAAAKAAKYGARPGVGVGGIPTY-----------------GVGAGGFPGFGVGVG 402
                +  A    + G R   G  GIP+                    G+ GFPG      
Sbjct: 931  KMGPSGRAGTPGEKGDRGNPGPVGIPSPRRPMSNLWLKGDKGSQGSAGSNGFPG----PR 986

Query: 403  GIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGV 462
            G  G AG PG  G+PG  G+PG+      +          GL PG+  + G+   PG+  
Sbjct: 987  GDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMGIRGL-PGLKGSSGITGFPGM-- 1043

Query: 463  APGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGA-GI 521
             PG   + G+  +PG+   PG    PG+  G      + +     K Q   +   G  G 
Sbjct: 1044 -PGESGSQGIRGSPGL---PGASGLPGL-KGDNGQTVEISGSPGPKGQPGESGFKGTKGR 1098

Query: 522  PGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALG 581
             GL   +G PG     G  G+    G+PG    PG   A    + G  +PG  G  GA+G
Sbjct: 1099 DGLIGNIGFPGNKGEDGKVGVSGDVGLPGAPGFPGV--AGMRGEPG--LPGSSGHQGAIG 1154

Query: 582  GVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGG-LGVPGVGGLGGIPPA 640
             +G PG +   G                 G  G  G    GV G  G+PG  G  G P  
Sbjct: 1155 PLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKGYPGI 1214

Query: 641  AAAKAAKYGVAARPGFGLSPIFPGGACLGKACG 673
                  K G+  + G    P   G A L  A G
Sbjct: 1215 GIGAPGKPGLRGQKGDRGFPGLQGPAGLPGAPG 1247



 Score =  139 bits (351), Expect = 7e-33
 Identities = 201/694 (28%), Positives = 266/694 (38%), Gaps = 114/694 (16%)

Query: 28  GVPGAIPGGVPG--GVFYPALGPGGKPLKPVPG-----GLAGAGLGAGL-GAFPAVTFPG 79
           G+PG  P G  G  GV  P    G K     PG     G+ G     GL G    +   G
Sbjct: 297 GLPG--PRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLPGPDVFIDIDG 354

Query: 80  ALVPGGVADAAAAYKAAKAG-------AGLGGVPGVGGLGVSAGAVVPQPGAGVK----- 127
           A++ G   D          G        G  GVPG+  L    GA+ PQ   G+K     
Sbjct: 355 AVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALSGVPGALGPQGFPGLKGDQGN 414

Query: 128 PGK-------VPGV-GLPGVY--PGGVLPG----------ARFPGVGVLPGVPTGAGVK- 166
           PG+       +PG  GLPG    PG   P           + FPG+    G     G+K 
Sbjct: 415 PGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKESGFPGLRGEQGPKGNLGLKG 474

Query: 167 -PKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGK-----LPYGY 220
                G      G+P  GP G P P  P G  I  P L G  G   + G       P   
Sbjct: 475 IKGDSGFCACDGGVPNTGPPGEPGPPGPWGL-IGLPGLKGARGDRGSGGAQGPAGAPGLV 533

Query: 221 GPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIP 280
           GP G +G  GK G P  + +  Q        + ++   G  GV+   G  GVPG+PG +P
Sbjct: 534 GPLGPSGPKGKKGEPILSTI--QGMPGDRGDSGSQ---GFRGVIGEPGKDGVPGLPG-LP 587

Query: 281 GIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFG----PGVVGVPGA----GVP 332
           G+ G  G G P          +    G      PG PG G    PG  G+PG     G+P
Sbjct: 588 GLPGDGGQGFPGEKGLPGLPGEKGHPGP-----PGLPGNGLPGLPGPRGLPGDKGKDGLP 642

Query: 333 GV-GVPGA-GIP---VVPGA----GIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGG 383
           G  G+PG+ GI    ++PG+    G PG   PG   P+ +        + G+    G  G
Sbjct: 643 GQQGLPGSKGITLPCIIPGSYGPSGFPGT--PGFPGPKGSRGLPGTPGQPGSSGSKGEPG 700

Query: 384 IP--TYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAK 441
            P   +     GFPG   G  G+PG  G+PG  G+PG+ G PG+   P ++ A       
Sbjct: 701 SPGLVHLPELPGFPG-PRGEKGLPGFPGLPGKDGLPGMIGSPGL---PGSKGATGDIFGA 756

Query: 442 YGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKS 501
               PG     G+    G     G+    GV   PG+    G   +PG  PG V      
Sbjct: 757 ENGAPGEQGLQGLTGHKGFLGDSGLPGLKGVHGKPGLLGPKGERGSPGT-PGQVGQPGTP 815

Query: 502 AAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAA 561
            +      + ++      G PG+    G  G     G PG  V  G+PG   +PG     
Sbjct: 816 GSSGPYGIKGKSGLPGAPGFPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKGLPGN---- 871

Query: 562 KAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL 621
                    PG++G  G+ G  G+ G    +GP           +    G VG  G+ GL
Sbjct: 872 ---------PGLVGLKGSPGSPGVAGLPALSGP---------KGEKGSVGFVGFPGIPGL 913

Query: 622 GVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPG 655
                G+PG  GL GI P +  K    G A  PG
Sbjct: 914 P----GIPGTRGLKGI-PGSTGKMGPSGRAGTPG 942



 Score =  132 bits (332), Expect = 1e-30
 Identities = 209/738 (28%), Positives = 269/738 (36%), Gaps = 140/738 (18%)

Query: 1    MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGL 60
            + GL     +PG       +L P    G PG      PG V  P     G P    P G+
Sbjct: 781  LPGLKGVHGKPG-------LLGPKGERGSPGT-----PGQVGQP-----GTPGSSGPYGI 823

Query: 61   AGAGLGAGLGAFPAVT-FPGALVPGGVADAAAAY--KAAKAGAGLGGVPGVGGLGVSAGA 117
             G     G   FP ++  PG     G      +   K      GL G PG+ GL  S G+
Sbjct: 824  KGKSGLPGAPGFPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGS 883

Query: 118  --VVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGA 175
              V   P      G+   VG  G           FPG+  LPG+P   G+K   PG  G 
Sbjct: 884  PGVAGLPALSGPKGEKGSVGFVG-----------FPGIPGLPGIPGTRGLKG-IPGSTGK 931

Query: 176  F-----AGIPGV-------GPFGGPQPGVPLGYP-IKAPKLPGGYGLPYTTGKLPYGYGP 222
                  AG PG        GP G P P  P+    +K  K  G  G   + G  P   G 
Sbjct: 932  MGPSGRAGTPGEKGDRGNPGPVGIPSPRRPMSNLWLKGDK--GSQGSAGSNG-FPGPRGD 988

Query: 223  GGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGV-GGAGVPGVPGAIPG 281
             G AG  G  G P   G+ P      + K       G  G LPG+ G +G+ G PG +PG
Sbjct: 989  KGEAGRPGPPGLPGAPGL-PGIIKGVSGKPGPPGFMGIRG-LPGLKGSSGITGFPG-MPG 1045

Query: 282  IGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLV--------PGGPGFGP--------GVV 324
              G  G+ G+P    A+         G    +         PG  GF          G +
Sbjct: 1046 ESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPGESGFKGTKGRDGLIGNI 1105

Query: 325  GVPG-------AGVPG-VGVPGA-GIPVVPGA----GIPGAA----------VPGVVSPE 361
            G PG        GV G VG+PGA G P V G     G+PG++           PG++ P+
Sbjct: 1106 GFPGNKGEDGKVGVSGDVGLPGAPGFPGVAGMRGEPGLPGSSGHQGAIGPLGSPGLIGPK 1165

Query: 362  AAAKAAAKAAKYG--------ARPGVGVGGIPTYG-----VGAGGFPGFGVGVGGIPGV- 407
                        G          PG  + G+P         G  G+PG G+G  G PG+ 
Sbjct: 1166 GFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKGYPGIGIGAPGKPGLR 1225

Query: 408  -----AGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGV 462
                  G PG+ G  G+ G PG+ + P   A       + GL  G    PG    PG   
Sbjct: 1226 GQKGDRGFPGLQGPAGLPGAPGISL-PSLIAGQPGDPGRPGL-DGERGRPGPAGPPG--- 1280

Query: 463  APGVGLAPGVGVAPGVGVAPGV-GVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGI 521
             PG     G    PG    PG+ G     G  G+   +    ++  K  +R   G   G 
Sbjct: 1281 PPGPSSNQGDTGDPGF---PGIPGPKGPKGDQGIPGFSGLPGELGLKG-MRGEPGF-MGT 1335

Query: 522  PGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALG 581
            PG    VG PG     G PG+   AG  G   + G       A+     PG LG  G  G
Sbjct: 1336 PG---KVGPPG---DPGFPGMKGKAGPRGSSGLQGDPGQTPTAEAVQVPPGPLGLPGIDG 1389

Query: 582  GVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL--GVGGLGVPGVGGLGGIP- 638
              G+ G     GP     +          G+ G  G  GL    G LG PG+ GL G P 
Sbjct: 1390 IPGLTGDPGAQGPVGLQGSKGLP------GIPGKDGPSGLPGPPGALGDPGLPGLQGPPG 1443

Query: 639  -PAAAAKAAKYGVAARPG 655
               A  +   +G+   PG
Sbjct: 1444 FEGAPGQQGPFGMPGMPG 1461



 Score =  130 bits (328), Expect = 3e-30
 Identities = 207/697 (29%), Positives = 254/697 (36%), Gaps = 93/697 (13%)

Query: 20  ILHPSRPGGVPGAI-PGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFP 78
           I  P    G PGA+ P G PG       GP G P    P G  G G     G    V  P
Sbjct: 182 ITGPQGAPGFPGAVGPAGPPG-----LQGPPGPPGPLGPDGNMGLGFQGEKGVKGDVGLP 236

Query: 79  GALVPGGVADAAAAYKAAKAGAGLGGVPGVGGL-GVSAGAVVPQPGAGVKPGKVPGVGLP 137
           G   P             K   G  G PG  G  G+S     P  G   + G+    G+P
Sbjct: 237 GPAGPPPSTGELEFMGFPKGKKGSKGEPGPKGFPGISGPPGFPGLGTTGEKGEKGEKGIP 296

Query: 138 GVYPGGVLPGARFP-GVGVLPGVPTGAGVKPKA--PGVGGAFAGIPGV-GPFGGPQPGVP 193
           G      LPG R P G   + G P   G K     PG+ G F GI G  G  G P P V 
Sbjct: 297 G------LPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNG-FQGIEGQKGDIGLPGPDVF 349

Query: 194 L---GYPIKA-PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV----GPQAA 245
           +   G  I   P  PG  GLP   G      G  G+ G +G  G P  +GV    GPQ  
Sbjct: 350 IDIDGAVISGNPGDPGVPGLPGLKGD----EGIQGLRGPSGVPGLPALSGVPGALGPQGF 405

Query: 246 AAAAAKAA--AKFGAGAAGVLPGVGGA-GVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAK 302
                      +   GAAG LPG  G  G PG PG          +    +        +
Sbjct: 406 PGLKGDQGNPGRTTIGAAG-LPGRDGLPGPPGPPGPPSPEFETETLHNKESGFPGLRGEQ 464

Query: 303 AAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGV-GVPGA----GIPVVPGA-------GIP 350
             K       + G  GF     GVP  G PG  G PG     G+P + GA       G  
Sbjct: 465 GPKGNLGLKGIKGDSGFCACDGGVPNTGPPGEPGPPGPWGLIGLPGLKGARGDRGSGGAQ 524

Query: 351 G-AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAG 409
           G A  PG+V P   +    K  +       G+ G      G  G  GF  GV G PG  G
Sbjct: 525 GPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPG----DRGDSGSQGFR-GVIGEPGKDG 579

Query: 410 VPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVA--PGVGVAPGVG 467
           VPG+ G+PG+ G  G G   E           +   PG+   PG G+   PG    PG  
Sbjct: 580 VPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGL---PGNGLPGLPGPRGLPGDK 636

Query: 468 LAPGVGVAPGVGVAPGVG---VAPG-IGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPG 523
              G+    G+  + G+    + PG  GP G            +    R   G   G PG
Sbjct: 637 GKDGLPGQQGLPGSKGITLPCIIPGSYGPSGFPGTPGFPGPKGS----RGLPGT-PGQPG 691

Query: 524 LGVGVGVPG------LGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGL 577
                G PG      L    G PG     G+PGF  +PG             +PG++G  
Sbjct: 692 SSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGFPGLPGK----------DGLPGMIGSP 741

Query: 578 GALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL-GVGG----LGVPGVG 632
           G  G  G  G + GA   A            + G +G +GL GL GV G    LG  G  
Sbjct: 742 GLPGSKGATGDIFGAENGAPGEQGLQGLTGHK-GFLGDSGLPGLKGVHGKPGLLGPKGER 800

Query: 633 GLGGIP-----PAAAAKAAKYGVAARPGFGLSPIFPG 664
           G  G P     P     +  YG+  + G   +P FPG
Sbjct: 801 GSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPG 837



 Score =  123 bits (309), Expect = 5e-28
 Identities = 203/715 (28%), Positives = 257/715 (35%), Gaps = 138/715 (19%)

Query: 43  YPALGPGGKPLKPV----PGGLAGAGLGAGLGAFPAVT-FPGALVPGGVADAAAAYKAAK 97
           +P  G  G+P  P+    P G  G     GL        FPG L P G        K  K
Sbjct: 43  FPEKGARGRP-GPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGP-------KGDK 94

Query: 98  AGAGLGGVPGVGGLGVSAGAVVPQ--PGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGV 155
              G+ G  G+ G+    G   P+  PG     G    VG PG  P G      +PG+  
Sbjct: 95  GPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPG--PDG------YPGLLG 146

Query: 156 LPGVPTGAGVKPKAPGVGGAF------AGIPGVGPFGGPQ--PGVPLGY-PIKAPKLPGG 206
            PG+P   G K       G+F       G+PG+    GPQ  PG P    P   P L G 
Sbjct: 147 PPGLPGQKGSKGDPVLAPGSFKGMKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGP 206

Query: 207 YGLP---YTTGKLPYGY----GPGGVAGAAGKAGYPTGTG----VG-PQAAAAAAAKAAA 254
            G P      G +  G+    G  G  G  G AG P  TG    +G P+    +  +   
Sbjct: 207 PGPPGPLGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGP 266

Query: 255 KFGAGAAGV--LPGVGGAGVPGVPG--AIPGIGGIAG-VGTPAAAAAAAAAAKAAKYGAA 309
           K   G +G    PG+G  G  G  G   IPG+ G  G +G+           K    G  
Sbjct: 267 KGFPGISGPPGFPGLGTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLG-- 324

Query: 310 AGLVPGGPGFGPGVVGVPG-AGVPG----VGVPGAGIPVVPG-AGIPGAAVPGVVSPEAA 363
               PG  GF  G+ G  G  G+PG    + + GA I   PG  G+PG  +PG+   E  
Sbjct: 325 ---FPGLNGF-QGIEGQKGDIGLPGPDVFIDIDGAVISGNPGDPGVPG--LPGLKGDEGI 378

Query: 364 AKAAAKAAKYGARPGVGVGGIPTY-----GVGAGGFPGF----------GVGVGGIPGVA 408
                     G R   GV G+P        +G  GFPG            +G  G+PG  
Sbjct: 379 ---------QGLRGPSGVPGLPALSGVPGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRD 429

Query: 409 GVPGVGGVPG--------------VGGVPGVGISPEAQAAAAAKAAK--------YGLVP 446
           G+PG  G PG                G PG+      +     K  K         G VP
Sbjct: 430 GLPGPPGPPGPPSPEFETETLHNKESGFPGLRGEQGPKGNLGLKGIKGDSGFCACDGGVP 489

Query: 447 GVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG-IGP-GGVAAAAKSAAK 504
             G  PG    PG     G+    G     G G A G   APG +GP G      K    
Sbjct: 490 NTG-PPGEPGPPGPWGLIGLPGLKGARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEP 548

Query: 505 VAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAA 564
           + +  Q         G+PG     G  G     G PG     G+PG   +PG        
Sbjct: 549 ILSTIQ---------GMPGDRGDSGSQGFRGVIGEPGKDGVPGLPGLPGLPGDGGQGFPG 599

Query: 565 KYGAAVPGVLGGLGALGGVGIPG-GVVG-AGPAAAAAAAKAAAKAAQFGLVGAAGL---- 618
           + G  +PG+ G  G  G  G+PG G+ G  GP              Q GL G+ G+    
Sbjct: 600 EKG--LPGLPGEKGHPGPPGLPGNGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGITLPC 657

Query: 619 ---GGLGVGGL----GVPGVGGLGGIP--PAAAAKAAKYGVAARPGFGLSPIFPG 664
              G  G  G     G PG  G  G+P  P     +   G    PG    P  PG
Sbjct: 658 IIPGSYGPSGFPGTPGFPGPKGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPG 712



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 155/530 (29%), Positives = 195/530 (36%), Gaps = 89/530 (16%)

Query: 183 GPFGGPQPGVPLGYPIKA--PKLPGGYGLPYTTGKLPYG----YGPGGVAGAAGKAGYPT 236
           GP G   P  P G+        L G  G P   G  PYG     GP GV G  G  G P 
Sbjct: 53  GPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLG--PYGPKGDKGPMGVPGFLGINGIPG 110

Query: 237 GTGV-GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAI--PGIGGIAGV-GTPA 292
             G  GP+               G  G    VG  G  G PG +  PG+ G  G  G P 
Sbjct: 111 HPGQPGPRGPPGLD---------GCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPV 161

Query: 293 AAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA-GVPGVGVPGAGIPVVPGA--GI 349
            A  +    K            G PG  PG+ G+ G  G PG   PGA  P  P    G 
Sbjct: 162 LAPGSFKGMK------------GDPGL-PGLDGITGPQGAPGF--PGAVGPAGPPGLQGP 206

Query: 350 PGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGI--PTYGVGAGGFPGFGVGVGGIPGV 407
           PG   PG + P+       +  K G +  VG+ G   P    G   F GF  G  G  G 
Sbjct: 207 PGP--PGPLGPDGNMGLGFQGEK-GVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGE 263

Query: 408 AGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVG 467
            G  G  G+ G  G PG+G + E       +  + G +PG+    G   + GV   PG  
Sbjct: 264 PGPKGFPGISGPPGFPGLGTTGEK-----GEKGEKG-IPGLPGPRGPMGSEGVQGPPGQQ 317

Query: 468 LAPGVGVAPGVGVAPGV-GVAPGIG-PGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLG 525
              G    PG+    G+ G    IG PG         A ++         GL    PGL 
Sbjct: 318 GKKGTLGFPGLNGFQGIEGQKGDIGLPGPDVFIDIDGAVISGNPGDPGVPGL----PGLK 373

Query: 526 VGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGI 585
              G+ GL   +GVPGL   +GVPG    P      K  + G      +G  G  G  G+
Sbjct: 374 GDEGIQGLRGPSGVPGLPALSGVPG-ALGPQGFPGLKGDQ-GNPGRTTIGAAGLPGRDGL 431

Query: 586 PGGVVGAGPAAAAAAAKAA-AKAAQF-GLVGAAG-LGGLGVGGL---------------- 626
           PG     GP +     +    K + F GL G  G  G LG+ G+                
Sbjct: 432 PGPPGPPGPPSPEFETETLHNKESGFPGLRGEQGPKGNLGLKGIKGDSGFCACDGGVPNT 491

Query: 627 ------GVPGVGGLGGIPPAAAAKAAK-----YGVAARPGFGLSPIFPGG 665
                 G PG  GL G+P    A+  +      G A  PG  + P+ P G
Sbjct: 492 GPPGEPGPPGPWGLIGLPGLKGARGDRGSGGAQGPAGAPGL-VGPLGPSG 540


>gi|16357503 type IV alpha 6 collagen isoform B precursor [Homo
            sapiens]
          Length = 1690

 Score =  147 bits (372), Expect = 2e-35
 Identities = 203/693 (29%), Positives = 258/693 (37%), Gaps = 91/693 (13%)

Query: 23   PSRPG--GVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGA-GLGAGLGAFPAVTFPG 79
            P  PG  G PG  P G+PG       GP G P      GL G  GL    G       PG
Sbjct: 603  PGLPGEKGHPG--PPGLPGNGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGITLPCIIPG 660

Query: 80   ALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGV 139
            +  P G       +   K   GL G PG  G   S G    +PG+   PG V    LPG 
Sbjct: 661  SYGPSGFP-GTPGFPGPKGSRGLPGTPGQPGSSGSKG----EPGS---PGLVHLPELPG- 711

Query: 140  YPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIK 199
                  PG R  G   LPG P G   K   PG+ G+  G+PG     G   G   G    
Sbjct: 712  -----FPGPR--GEKGLPGFP-GLPGKDGLPGMIGS-PGLPGSKGATGDIFGAENG---- 758

Query: 200  APKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGA 258
                PG  GL   TG   +  G  G+ G  G  G P   G  G + +     +       
Sbjct: 759  ---APGEQGLQGLTGHKGF-LGDSGLPGLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTP 814

Query: 259  GAAGVLPGVGGAGVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPGGP 317
            G++G     G +G+PG PG  PGI G  G  GT        +  K    G     +PG P
Sbjct: 815  GSSGPYGIKGKSGLPGAPG-FPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKG--LPGNP 871

Query: 318  GF--------GPGVVGVPGAGVPG--------VGVPGA-GIPVVPGA-GIPGAAVPGVVS 359
            G          PGV G+P    P         VG PG  G+P +PG  G+ G  +PG   
Sbjct: 872  GLVGLKGSPGSPGVAGLPALSGPKGEKGSVGFVGFPGIPGLPGIPGTRGLKG--IPGSTG 929

Query: 360  PEAAAKAAAKAAKYGARPGVGVGGIPTY-----------------GVGAGGFPGFGVGVG 402
                +  A    + G R   G  GIP+                    G+ GFPG      
Sbjct: 930  KMGPSGRAGTPGEKGDRGNPGPVGIPSPRRPMSNLWLKGDKGSQGSAGSNGFPG----PR 985

Query: 403  GIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGV 462
            G  G AG PG  G+PG  G+PG+      +          GL PG+  + G+   PG+  
Sbjct: 986  GDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMGIRGL-PGLKGSSGITGFPGM-- 1042

Query: 463  APGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGA-GI 521
             PG   + G+  +PG+   PG    PG+  G      + +     K Q   +   G  G 
Sbjct: 1043 -PGESGSQGIRGSPGL---PGASGLPGL-KGDNGQTVEISGSPGPKGQPGESGFKGTKGR 1097

Query: 522  PGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALG 581
             GL   +G PG     G  G+    G+PG    PG   A    + G  +PG  G  GA+G
Sbjct: 1098 DGLIGNIGFPGNKGEDGKVGVSGDVGLPGAPGFPGV--AGMRGEPG--LPGSSGHQGAIG 1153

Query: 582  GVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGG-LGVPGVGGLGGIPPA 640
             +G PG +   G                 G  G  G    GV G  G+PG  G  G P  
Sbjct: 1154 PLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKGYPGI 1213

Query: 641  AAAKAAKYGVAARPGFGLSPIFPGGACLGKACG 673
                  K G+  + G    P   G A L  A G
Sbjct: 1214 GIGAPGKPGLRGQKGDRGFPGLQGPAGLPGAPG 1246



 Score =  139 bits (351), Expect = 7e-33
 Identities = 201/694 (28%), Positives = 266/694 (38%), Gaps = 114/694 (16%)

Query: 28  GVPGAIPGGVPG--GVFYPALGPGGKPLKPVPG-----GLAGAGLGAGL-GAFPAVTFPG 79
           G+PG  P G  G  GV  P    G K     PG     G+ G     GL G    +   G
Sbjct: 296 GLPG--PRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLPGPDVFIDIDG 353

Query: 80  ALVPGGVADAAAAYKAAKAG-------AGLGGVPGVGGLGVSAGAVVPQPGAGVK----- 127
           A++ G   D          G        G  GVPG+  L    GA+ PQ   G+K     
Sbjct: 354 AVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALSGVPGALGPQGFPGLKGDQGN 413

Query: 128 PGK-------VPGV-GLPGVY--PGGVLPG----------ARFPGVGVLPGVPTGAGVK- 166
           PG+       +PG  GLPG    PG   P           + FPG+    G     G+K 
Sbjct: 414 PGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKESGFPGLRGEQGPKGNLGLKG 473

Query: 167 -PKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGK-----LPYGY 220
                G      G+P  GP G P P  P G  I  P L G  G   + G       P   
Sbjct: 474 IKGDSGFCACDGGVPNTGPPGEPGPPGPWGL-IGLPGLKGARGDRGSGGAQGPAGAPGLV 532

Query: 221 GPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIP 280
           GP G +G  GK G P  + +  Q        + ++   G  GV+   G  GVPG+PG +P
Sbjct: 533 GPLGPSGPKGKKGEPILSTI--QGMPGDRGDSGSQ---GFRGVIGEPGKDGVPGLPG-LP 586

Query: 281 GIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFG----PGVVGVPGA----GVP 332
           G+ G  G G P          +    G      PG PG G    PG  G+PG     G+P
Sbjct: 587 GLPGDGGQGFPGEKGLPGLPGEKGHPGP-----PGLPGNGLPGLPGPRGLPGDKGKDGLP 641

Query: 333 GV-GVPGA-GIP---VVPGA----GIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGG 383
           G  G+PG+ GI    ++PG+    G PG   PG   P+ +        + G+    G  G
Sbjct: 642 GQQGLPGSKGITLPCIIPGSYGPSGFPGT--PGFPGPKGSRGLPGTPGQPGSSGSKGEPG 699

Query: 384 IP--TYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAK 441
            P   +     GFPG   G  G+PG  G+PG  G+PG+ G PG+   P ++ A       
Sbjct: 700 SPGLVHLPELPGFPG-PRGEKGLPGFPGLPGKDGLPGMIGSPGL---PGSKGATGDIFGA 755

Query: 442 YGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKS 501
               PG     G+    G     G+    GV   PG+    G   +PG  PG V      
Sbjct: 756 ENGAPGEQGLQGLTGHKGFLGDSGLPGLKGVHGKPGLLGPKGERGSPGT-PGQVGQPGTP 814

Query: 502 AAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAA 561
            +      + ++      G PG+    G  G     G PG  V  G+PG   +PG     
Sbjct: 815 GSSGPYGIKGKSGLPGAPGFPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKGLPGN---- 870

Query: 562 KAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL 621
                    PG++G  G+ G  G+ G    +GP           +    G VG  G+ GL
Sbjct: 871 ---------PGLVGLKGSPGSPGVAGLPALSGP---------KGEKGSVGFVGFPGIPGL 912

Query: 622 GVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPG 655
                G+PG  GL GI P +  K    G A  PG
Sbjct: 913 P----GIPGTRGLKGI-PGSTGKMGPSGRAGTPG 941



 Score =  132 bits (332), Expect = 1e-30
 Identities = 209/738 (28%), Positives = 269/738 (36%), Gaps = 140/738 (18%)

Query: 1    MAGLTAAAPRPGVLLLLLSILHPSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGL 60
            + GL     +PG       +L P    G PG      PG V  P     G P    P G+
Sbjct: 780  LPGLKGVHGKPG-------LLGPKGERGSPGT-----PGQVGQP-----GTPGSSGPYGI 822

Query: 61   AGAGLGAGLGAFPAVT-FPGALVPGGVADAAAAY--KAAKAGAGLGGVPGVGGLGVSAGA 117
             G     G   FP ++  PG     G      +   K      GL G PG+ GL  S G+
Sbjct: 823  KGKSGLPGAPGFPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGS 882

Query: 118  --VVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGA 175
              V   P      G+   VG  G           FPG+  LPG+P   G+K   PG  G 
Sbjct: 883  PGVAGLPALSGPKGEKGSVGFVG-----------FPGIPGLPGIPGTRGLKG-IPGSTGK 930

Query: 176  F-----AGIPGV-------GPFGGPQPGVPLGYP-IKAPKLPGGYGLPYTTGKLPYGYGP 222
                  AG PG        GP G P P  P+    +K  K  G  G   + G  P   G 
Sbjct: 931  MGPSGRAGTPGEKGDRGNPGPVGIPSPRRPMSNLWLKGDK--GSQGSAGSNG-FPGPRGD 987

Query: 223  GGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGV-GGAGVPGVPGAIPG 281
             G AG  G  G P   G+ P      + K       G  G LPG+ G +G+ G PG +PG
Sbjct: 988  KGEAGRPGPPGLPGAPGL-PGIIKGVSGKPGPPGFMGIRG-LPGLKGSSGITGFPG-MPG 1044

Query: 282  IGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLV--------PGGPGFGP--------GVV 324
              G  G+ G+P    A+         G    +         PG  GF          G +
Sbjct: 1045 ESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPGESGFKGTKGRDGLIGNI 1104

Query: 325  GVPG-------AGVPG-VGVPGA-GIPVVPGA----GIPGAA----------VPGVVSPE 361
            G PG        GV G VG+PGA G P V G     G+PG++           PG++ P+
Sbjct: 1105 GFPGNKGEDGKVGVSGDVGLPGAPGFPGVAGMRGEPGLPGSSGHQGAIGPLGSPGLIGPK 1164

Query: 362  AAAKAAAKAAKYG--------ARPGVGVGGIPTYG-----VGAGGFPGFGVGVGGIPGV- 407
                        G          PG  + G+P         G  G+PG G+G  G PG+ 
Sbjct: 1165 GFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKGYPGIGIGAPGKPGLR 1224

Query: 408  -----AGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGV 462
                  G PG+ G  G+ G PG+ + P   A       + GL  G    PG    PG   
Sbjct: 1225 GQKGDRGFPGLQGPAGLPGAPGISL-PSLIAGQPGDPGRPGL-DGERGRPGPAGPPG--- 1279

Query: 463  APGVGLAPGVGVAPGVGVAPGV-GVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGI 521
             PG     G    PG    PG+ G     G  G+   +    ++  K  +R   G   G 
Sbjct: 1280 PPGPSSNQGDTGDPGF---PGIPGPKGPKGDQGIPGFSGLPGELGLKG-MRGEPGF-MGT 1334

Query: 522  PGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALG 581
            PG    VG PG     G PG+   AG  G   + G       A+     PG LG  G  G
Sbjct: 1335 PG---KVGPPG---DPGFPGMKGKAGPRGSSGLQGDPGQTPTAEAVQVPPGPLGLPGIDG 1388

Query: 582  GVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL--GVGGLGVPGVGGLGGIP- 638
              G+ G     GP     +          G+ G  G  GL    G LG PG+ GL G P 
Sbjct: 1389 IPGLTGDPGAQGPVGLQGSKGLP------GIPGKDGPSGLPGPPGALGDPGLPGLQGPPG 1442

Query: 639  -PAAAAKAAKYGVAARPG 655
               A  +   +G+   PG
Sbjct: 1443 FEGAPGQQGPFGMPGMPG 1460



 Score =  130 bits (328), Expect = 3e-30
 Identities = 207/697 (29%), Positives = 254/697 (36%), Gaps = 93/697 (13%)

Query: 20  ILHPSRPGGVPGAI-PGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFP 78
           I  P    G PGA+ P G PG       GP G P    P G  G G     G    V  P
Sbjct: 181 ITGPQGAPGFPGAVGPAGPPG-----LQGPPGPPGPLGPDGNMGLGFQGEKGVKGDVGLP 235

Query: 79  GALVPGGVADAAAAYKAAKAGAGLGGVPGVGGL-GVSAGAVVPQPGAGVKPGKVPGVGLP 137
           G   P             K   G  G PG  G  G+S     P  G   + G+    G+P
Sbjct: 236 GPAGPPPSTGELEFMGFPKGKKGSKGEPGPKGFPGISGPPGFPGLGTTGEKGEKGEKGIP 295

Query: 138 GVYPGGVLPGARFP-GVGVLPGVPTGAGVKPKA--PGVGGAFAGIPGV-GPFGGPQPGVP 193
           G      LPG R P G   + G P   G K     PG+ G F GI G  G  G P P V 
Sbjct: 296 G------LPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNG-FQGIEGQKGDIGLPGPDVF 348

Query: 194 L---GYPIKA-PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV----GPQAA 245
           +   G  I   P  PG  GLP   G      G  G+ G +G  G P  +GV    GPQ  
Sbjct: 349 IDIDGAVISGNPGDPGVPGLPGLKGD----EGIQGLRGPSGVPGLPALSGVPGALGPQGF 404

Query: 246 AAAAAKAA--AKFGAGAAGVLPGVGGA-GVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAK 302
                      +   GAAG LPG  G  G PG PG          +    +        +
Sbjct: 405 PGLKGDQGNPGRTTIGAAG-LPGRDGLPGPPGPPGPPSPEFETETLHNKESGFPGLRGEQ 463

Query: 303 AAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGV-GVPGA----GIPVVPGA-------GIP 350
             K       + G  GF     GVP  G PG  G PG     G+P + GA       G  
Sbjct: 464 GPKGNLGLKGIKGDSGFCACDGGVPNTGPPGEPGPPGPWGLIGLPGLKGARGDRGSGGAQ 523

Query: 351 G-AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAG 409
           G A  PG+V P   +    K  +       G+ G      G  G  GF  GV G PG  G
Sbjct: 524 GPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPG----DRGDSGSQGFR-GVIGEPGKDG 578

Query: 410 VPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVA--PGVGVAPGVG 467
           VPG+ G+PG+ G  G G   E           +   PG+   PG G+   PG    PG  
Sbjct: 579 VPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGL---PGNGLPGLPGPRGLPGDK 635

Query: 468 LAPGVGVAPGVGVAPGVG---VAPG-IGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPG 523
              G+    G+  + G+    + PG  GP G            +    R   G   G PG
Sbjct: 636 GKDGLPGQQGLPGSKGITLPCIIPGSYGPSGFPGTPGFPGPKGS----RGLPGT-PGQPG 690

Query: 524 LGVGVGVPG------LGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGL 577
                G PG      L    G PG     G+PGF  +PG             +PG++G  
Sbjct: 691 SSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGFPGLPGK----------DGLPGMIGSP 740

Query: 578 GALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL-GVGG----LGVPGVG 632
           G  G  G  G + GA   A            + G +G +GL GL GV G    LG  G  
Sbjct: 741 GLPGSKGATGDIFGAENGAPGEQGLQGLTGHK-GFLGDSGLPGLKGVHGKPGLLGPKGER 799

Query: 633 GLGGIP-----PAAAAKAAKYGVAARPGFGLSPIFPG 664
           G  G P     P     +  YG+  + G   +P FPG
Sbjct: 800 GSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPG 836



 Score =  123 bits (309), Expect = 5e-28
 Identities = 203/715 (28%), Positives = 257/715 (35%), Gaps = 138/715 (19%)

Query: 43  YPALGPGGKPLKPV----PGGLAGAGLGAGLGAFPAVT-FPGALVPGGVADAAAAYKAAK 97
           +P  G  G+P  P+    P G  G     GL        FPG L P G        K  K
Sbjct: 42  FPEKGARGRP-GPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGP-------KGDK 93

Query: 98  AGAGLGGVPGVGGLGVSAGAVVPQ--PGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGV 155
              G+ G  G+ G+    G   P+  PG     G    VG PG  P G      +PG+  
Sbjct: 94  GPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPG--PDG------YPGLLG 145

Query: 156 LPGVPTGAGVKPKAPGVGGAF------AGIPGVGPFGGPQ--PGVPLGY-PIKAPKLPGG 206
            PG+P   G K       G+F       G+PG+    GPQ  PG P    P   P L G 
Sbjct: 146 PPGLPGQKGSKGDPVLAPGSFKGMKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGP 205

Query: 207 YGLP---YTTGKLPYGY----GPGGVAGAAGKAGYPTGTG----VG-PQAAAAAAAKAAA 254
            G P      G +  G+    G  G  G  G AG P  TG    +G P+    +  +   
Sbjct: 206 PGPPGPLGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGP 265

Query: 255 KFGAGAAGV--LPGVGGAGVPGVPG--AIPGIGGIAG-VGTPAAAAAAAAAAKAAKYGAA 309
           K   G +G    PG+G  G  G  G   IPG+ G  G +G+           K    G  
Sbjct: 266 KGFPGISGPPGFPGLGTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLG-- 323

Query: 310 AGLVPGGPGFGPGVVGVPG-AGVPG----VGVPGAGIPVVPG-AGIPGAAVPGVVSPEAA 363
               PG  GF  G+ G  G  G+PG    + + GA I   PG  G+PG  +PG+   E  
Sbjct: 324 ---FPGLNGF-QGIEGQKGDIGLPGPDVFIDIDGAVISGNPGDPGVPG--LPGLKGDEGI 377

Query: 364 AKAAAKAAKYGARPGVGVGGIPTY-----GVGAGGFPGF----------GVGVGGIPGVA 408
                     G R   GV G+P        +G  GFPG            +G  G+PG  
Sbjct: 378 ---------QGLRGPSGVPGLPALSGVPGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRD 428

Query: 409 GVPGVGGVPG--------------VGGVPGVGISPEAQAAAAAKAAK--------YGLVP 446
           G+PG  G PG                G PG+      +     K  K         G VP
Sbjct: 429 GLPGPPGPPGPPSPEFETETLHNKESGFPGLRGEQGPKGNLGLKGIKGDSGFCACDGGVP 488

Query: 447 GVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG-IGP-GGVAAAAKSAAK 504
             G  PG    PG     G+    G     G G A G   APG +GP G      K    
Sbjct: 489 NTG-PPGEPGPPGPWGLIGLPGLKGARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEP 547

Query: 505 VAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAA 564
           + +  Q         G+PG     G  G     G PG     G+PG   +PG        
Sbjct: 548 ILSTIQ---------GMPGDRGDSGSQGFRGVIGEPGKDGVPGLPGLPGLPGDGGQGFPG 598

Query: 565 KYGAAVPGVLGGLGALGGVGIPG-GVVG-AGPAAAAAAAKAAAKAAQFGLVGAAGL---- 618
           + G  +PG+ G  G  G  G+PG G+ G  GP              Q GL G+ G+    
Sbjct: 599 EKG--LPGLPGEKGHPGPPGLPGNGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGITLPC 656

Query: 619 ---GGLGVGGL----GVPGVGGLGGIP--PAAAAKAAKYGVAARPGFGLSPIFPG 664
              G  G  G     G PG  G  G+P  P     +   G    PG    P  PG
Sbjct: 657 IIPGSYGPSGFPGTPGFPGPKGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPG 711



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 155/530 (29%), Positives = 195/530 (36%), Gaps = 89/530 (16%)

Query: 183 GPFGGPQPGVPLGYPIKA--PKLPGGYGLPYTTGKLPYG----YGPGGVAGAAGKAGYPT 236
           GP G   P  P G+        L G  G P   G  PYG     GP GV G  G  G P 
Sbjct: 52  GPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLG--PYGPKGDKGPMGVPGFLGINGIPG 109

Query: 237 GTGV-GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAI--PGIGGIAGV-GTPA 292
             G  GP+               G  G    VG  G  G PG +  PG+ G  G  G P 
Sbjct: 110 HPGQPGPRGPPGLD---------GCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPV 160

Query: 293 AAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA-GVPGVGVPGAGIPVVPGA--GI 349
            A  +    K            G PG  PG+ G+ G  G PG   PGA  P  P    G 
Sbjct: 161 LAPGSFKGMK------------GDPGL-PGLDGITGPQGAPGF--PGAVGPAGPPGLQGP 205

Query: 350 PGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGI--PTYGVGAGGFPGFGVGVGGIPGV 407
           PG   PG + P+       +  K G +  VG+ G   P    G   F GF  G  G  G 
Sbjct: 206 PGP--PGPLGPDGNMGLGFQGEK-GVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGE 262

Query: 408 AGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVG 467
            G  G  G+ G  G PG+G + E       +  + G +PG+    G   + GV   PG  
Sbjct: 263 PGPKGFPGISGPPGFPGLGTTGEK-----GEKGEKG-IPGLPGPRGPMGSEGVQGPPGQQ 316

Query: 468 LAPGVGVAPGVGVAPGV-GVAPGIG-PGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLG 525
              G    PG+    G+ G    IG PG         A ++         GL    PGL 
Sbjct: 317 GKKGTLGFPGLNGFQGIEGQKGDIGLPGPDVFIDIDGAVISGNPGDPGVPGL----PGLK 372

Query: 526 VGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGI 585
              G+ GL   +GVPGL   +GVPG    P      K  + G      +G  G  G  G+
Sbjct: 373 GDEGIQGLRGPSGVPGLPALSGVPG-ALGPQGFPGLKGDQ-GNPGRTTIGAAGLPGRDGL 430

Query: 586 PGGVVGAGPAAAAAAAKAA-AKAAQF-GLVGAAG-LGGLGVGGL---------------- 626
           PG     GP +     +    K + F GL G  G  G LG+ G+                
Sbjct: 431 PGPPGPPGPPSPEFETETLHNKESGFPGLRGEQGPKGNLGLKGIKGDSGFCACDGGVPNT 490

Query: 627 ------GVPGVGGLGGIPPAAAAKAAK-----YGVAARPGFGLSPIFPGG 665
                 G PG  GL G+P    A+  +      G A  PG  + P+ P G
Sbjct: 491 GPPGEPGPPGPWGLIGLPGLKGARGDRGSGGAQGPAGAPGL-VGPLGPSG 539


>gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]
          Length = 1626

 Score =  144 bits (362), Expect = 3e-34
 Identities = 232/769 (30%), Positives = 277/769 (36%), Gaps = 157/769 (20%)

Query: 23   PSRPG-----GVPGAI-PGGVPGGVFYPALGPGGKPLKPVPGGLAGA-GLGA-------- 67
            P R G     G PG +   G+PG V     GP G P  P P G  GA GL          
Sbjct: 541  PGRDGSKGMRGEPGELGEPGLPGEV--GMRGPQGPPGLPGPPGRVGAPGLQGERGEKGTR 598

Query: 68   ------GLGAFPA----VTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGA 117
                  GL  FP         G   P GVA      +  K   G  G PGV G  V    
Sbjct: 599  GEKGERGLDGFPGKPGDTGQQGRPGPSGVAGP----QGEKGDVGPAGPPGVPGSVVQQEG 654

Query: 118  VVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFP-GVGVLPGVPTGAGVKPK-----APG 171
            +  + GA   PG     G PG       PGAR P G     G P   G++ K      PG
Sbjct: 655  LKGEQGA---PGPRGHQGAPGP------PGARGPIGPEGRDGPPGLQGLRGKKGDMGPPG 705

Query: 172  VGGAFA-----GIPGV-GPFG-GPQPGVP--LGYPIKAPKLPGGYGLPYTTGK--LPYGY 220
            + G        G PGV GP G G  PG+P  +G+P K P  PG  G P   G    P   
Sbjct: 706  IPGLLGLQGPPGPPGVPGPPGPGGSPGLPGEIGFPGK-PGPPGPTGPPGKDGPNGPPGPP 764

Query: 221  GPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGAGAAGV--LPGV---------- 267
            G  G  G  G+ G P   G+ G       A +   K  AG  G    PGV          
Sbjct: 765  GTKGEPGERGEDGLPGKPGLRGEIGEQGLAGRPGEKGEAGLPGAPGFPGVRGEKGDQGEK 824

Query: 268  GGAGVPGV-----------PGAIPGIGGIAGVGTPAAAAAAAAAAKAAK----------- 305
            G  G+PG+           P   PG+ G   + TP          K  K           
Sbjct: 825  GELGLPGLKGDRGEKGEAGPAGPPGLPGTTSLFTPHPRMPGEQGPKGEKGDPGLPGEPGL 884

Query: 306  YGAAAGLVPGGPGFGPGVVGVPGA-GVPGVGVPGAGIPVVPG-AGIPG-AAVPGVVSPEA 362
             G    L P GP   PG  G  GA G PG     AG P  PG  G PG +  PG V    
Sbjct: 885  QGRPGELGPQGPTGPPGAKGQEGAHGAPG----AAGNPGAPGHVGAPGPSGPPGSVGAPG 940

Query: 363  AAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVG--GVPGVG 420
                  K  + G +   G  G P   VG  G P       G PG+ G PG G  G PG+ 
Sbjct: 941  LRGTPGKDGERGEKGAAGEEGSPG-PVGPRGDP-------GAPGLPGPPGKGKDGEPGLR 992

Query: 421  GVPGVGISPEAQAAAAAK-------AAKYGLVPGVGVAPGVGVAPGVGVAPGVGLA--PG 471
            G PG+   P    AA  K       A     V G   APG+  +PG    PG+G+A  PG
Sbjct: 993  GSPGLP-GPLGTKAACGKVRGSENCALGGQCVKGDRGAPGIPGSPGSRGDPGIGVAGPPG 1051

Query: 472  VGVAPGVGVAPGVGVAPGI----GPGGVAAAAKSAAK--VAAKAQLRAAAGLG------- 518
                PG   +PG    PG     GP G   A  +  +     K  L +    G       
Sbjct: 1052 PSGPPGDKGSPGSRGLPGFPGPQGPAGRDGAPGNPGERGPPGKPGLSSLLSPGDINLLAK 1111

Query: 519  -------------AGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAK 565
                          G+PG     GVPG     G  G    AG PG    PG +A  + ++
Sbjct: 1112 DVCNDCPPGPPGLPGLPGFKGDKGVPGKPGREGTEGKKGEAGPPGLPGPPG-IAGPQGSQ 1170

Query: 566  YGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGL----GGL 621
                  G +G  G  G  G+PG +   G      A   A  A   G+ G+ G     G  
Sbjct: 1171 GERGADGEVGQKGDQGHPGVPGFMGPPGNPGPPGADGIAGAAGPPGIQGSPGKEGPPGPQ 1230

Query: 622  GVGGL-GVPGVGGLGGI-----PPAAAAKAAKYGVAARPGFGLSPIFPG 664
            G  GL G+PG  G  G      PP    KA + G+    G    P F G
Sbjct: 1231 GPSGLPGIPGEEGKEGRDGKPGPPGEPGKAGEPGLPGPEGARGPPGFKG 1279



 Score =  120 bits (300), Expect = 5e-27
 Identities = 203/705 (28%), Positives = 240/705 (34%), Gaps = 135/705 (19%)

Query: 22   HPSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGAL 81
            +P  PG V    P G PG V  P L   G P K    G  GA    G         PG +
Sbjct: 917  NPGAPGHVGAPGPSGPPGSVGAPGL--RGTPGKDGERGEKGAAGEEG--------SPGPV 966

Query: 82   VPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQP-GAGVKPGKVPGVGLPGVY 140
             P G  D  A       G G  G PG+ G   S G  +P P G     GKV G       
Sbjct: 967  GPRG--DPGAPGLPGPPGKGKDGEPGLRG---SPG--LPGPLGTKAACGKVRG------S 1013

Query: 141  PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKA 200
                L G    G    PG+P   G +           G PG+G  G P P  P       
Sbjct: 1014 ENCALGGQCVKGDRGAPGIPGSPGSR-----------GDPGIGVAGPPGPSGP------- 1055

Query: 201  PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTG----------VGPQAAAAAAA 250
               PG  G P + G LP   GP G AG  G  G P   G          + P      A 
Sbjct: 1056 ---PGDKGSPGSRG-LPGFPGPQGPAGRDGAPGNPGERGPPGKPGLSSLLSPGDINLLAK 1111

Query: 251  KAAAKFGAGAAGV--LPGV-GGAGVPGVPG-----------AIPGIGGIAGVGTPAAAAA 296
                    G  G+  LPG  G  GVPG PG             PG+ G  G+  P  +  
Sbjct: 1112 DVCNDCPPGPPGLPGLPGFKGDKGVPGKPGREGTEGKKGEAGPPGLPGPPGIAGPQGSQG 1171

Query: 297  AAAAAKAAKYGAAAGLVPGGPGF--GPGVVGVPGA-GVPGVGVPGAGIPVVPG-AGIPG- 351
               A          G  PG PGF   PG  G PGA G+ G   P  GI   PG  G PG 
Sbjct: 1172 ERGADGEVGQKGDQG-HPGVPGFMGPPGNPGPPGADGIAGAAGP-PGIQGSPGKEGPPGP 1229

Query: 352  ---AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGF--GVGVGGIPG 406
               + +PG+   E       K    G     G  G+P    GA G PGF    G  G PG
Sbjct: 1230 QGPSGLPGIPGEEGKEGRDGKPGPPGEPGKAGEPGLPG-PEGARGPPGFKGHTGDSGAPG 1288

Query: 407  VAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGV 466
              G  G  G+PG  G+PG             +  +    PG   +PG    PG    PG 
Sbjct: 1289 PRGESGAMGLPGQEGLPGKDGDTGPTGPQGPQGPRG--PPGKNGSPGSPGEPGPSGTPGQ 1346

Query: 467  GLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGV 526
              + G   +PG+    G    PG  PG      K    V  K           G PG   
Sbjct: 1347 KGSKGENGSPGLPGFLGPRGPPG-EPGEKGVPGKEG--VPGK----------PGEPGFKG 1393

Query: 527  GVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIP 586
              G PG+    G PG   G G PG   +PG             +PG  G +G  G  G P
Sbjct: 1394 ERGDPGIKGDKGPPG---GKGQPGDPGIPGH-KGHTGLMGPQGLPGENGPVGPPGPPGQP 1449

Query: 587  G--GVVGAGPA------------------------AAAAAAKAAAKAAQFGLVGAAGLGG 620
            G  G+ G  P+                        A    A   +   + G  G  G  G
Sbjct: 1450 GFPGLRGESPSMETLRRLIQEELGKQLETRLAYLLAQMPPAYMKSSQGRPGPPGPPGKDG 1509

Query: 621  L--GVGGLGVPGVGGLGGI-----PPAAAAKAAKYGVAARPGFGL 658
            L    G +G PG  G GG+     P     +    G    PG GL
Sbjct: 1510 LPGRAGPMGEPGRPGQGGLEGPSGPIGPKGERGAKGDPGAPGVGL 1554



 Score =  110 bits (274), Expect = 6e-24
 Identities = 202/700 (28%), Positives = 233/700 (33%), Gaps = 111/700 (15%)

Query: 28   GVPGAI-PGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGV 86
            G PG + P G PG    P  GP GK     PG     GL   LG   A    G +   G 
Sbjct: 961  GSPGPVGPRGDPGAPGLP--GPPGKGKDGEPGLRGSPGLPGPLGTKAAC---GKV--RGS 1013

Query: 87   ADAAAAYKAAKAGAGLGGVPGVGGLGVSAG-AVVPQPGAGVKPGKVPGVGLPGVYPGGVL 145
             + A   +  K   G  G+PG  G     G  V   PG    PG     G  G      L
Sbjct: 1014 ENCALGGQCVKGDRGAPGIPGSPGSRGDPGIGVAGPPGPSGPPGDKGSPGSRG------L 1067

Query: 146  PGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQP----------GVPLG 195
            PG  FPG    P  P G    P  PG  G   G PG+     P              P G
Sbjct: 1068 PG--FPG----PQGPAGRDGAPGNPGERGP-PGKPGLSSLLSPGDINLLAKDVCNDCPPG 1120

Query: 196  YPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAK 255
             P   P LPG  G     GK P   G  G  G AG  G P   G+     +     A  +
Sbjct: 1121 PP-GLPGLPGFKGDKGVPGK-PGREGTEGKKGEAGPPGLPGPPGIAGPQGSQGERGADGE 1178

Query: 256  FGAGAAGVLPGVGG-AGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGL-- 312
             G       PGV G  G PG PG  PG  GIAG   P     +            +GL  
Sbjct: 1179 VGQKGDQGHPGVPGFMGPPGNPGP-PGADGIAGAAGPPGIQGSPGKEGPPGPQGPSGLPG 1237

Query: 313  VPG-----------GPGFGPGVVGVPGA-------GVPGV-------GVPG----AGIPV 343
            +PG           GP   PG  G PG        G PG        G PG    +G   
Sbjct: 1238 IPGEEGKEGRDGKPGPPGEPGKAGEPGLPGPEGARGPPGFKGHTGDSGAPGPRGESGAMG 1297

Query: 344  VPGA-GIPG----AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAG-----G 393
            +PG  G+PG        G   P+       K    G+    G  G P      G     G
Sbjct: 1298 LPGQEGLPGKDGDTGPTGPQGPQGPRGPPGKNGSPGSPGEPGPSGTPGQKGSKGENGSPG 1357

Query: 394  FPGF--GVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGL-VPGVGV 450
             PGF    G  G PG  GVPG  GVPG  G PG             K    G   PG   
Sbjct: 1358 LPGFLGPRGPPGEPGEKGVPGKEGVPGKPGEPGFKGERGDPGIKGDKGPPGGKGQPGDPG 1417

Query: 451  APGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQ 510
             PG     G+    G+    G    PG    PG     G  P           ++  + +
Sbjct: 1418 IPGHKGHTGLMGPQGLPGENGPVGPPGPPGQPGFPGLRGESPSMETLRRLIQEELGKQLE 1477

Query: 511  LRAAAGLG-------------AGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGA 557
             R A  L               G PG     G+PG     G PG     G+ G  + P  
Sbjct: 1478 TRLAYLLAQMPPAYMKSSQGRPGPPGPPGKDGLPGRAGPMGEPGRPGQGGLEG-PSGPIG 1536

Query: 558  LAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAG 617
                + AK     PGV G  G +G  GIPG     G              A+ GL G  G
Sbjct: 1537 PKGERGAKGDPGAPGV-GLRGEMGPPGIPGQPGEPG-------------YAKDGLPGIPG 1582

Query: 618  LGGLGVGGLGVPGVGGLGGIPPAAAAKAAKY--GVAARPG 655
              G   G  G PG+ G  G P         Y   +AARPG
Sbjct: 1583 PQG-ETGPAGHPGLPGPPGPPGQCDPSQCAYFASLAARPG 1621



 Score =  107 bits (268), Expect = 3e-23
 Identities = 185/649 (28%), Positives = 224/649 (34%), Gaps = 116/649 (17%)

Query: 28   GVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGAL--VPGG 85
            G PG IPG  PG    P +G  G P    P G  G+    GL  FP    P      PG 
Sbjct: 1028 GAPG-IPGS-PGSRGDPGIGVAGPPGPSGPPGDKGSPGSRGLPGFPGPQGPAGRDGAPGN 1085

Query: 86   VADAAAAYKAAKAGA-------------------GLGGVPGVGGLGVSAGAVVPQPGAGV 126
              +     K   +                     G  G+PG+ G     G V  +PG   
Sbjct: 1086 PGERGPPGKPGLSSLLSPGDINLLAKDVCNDCPPGPPGLPGLPGFKGDKG-VPGKPGREG 1144

Query: 127  KPGKVPGVGLPGVY--PGGVLP----GAR-------------FPGVGVLPGVPTGAGVKP 167
              GK    G PG+   PG   P    G R              PGV    G P   G  P
Sbjct: 1145 TEGKKGEAGPPGLPGPPGIAGPQGSQGERGADGEVGQKGDQGHPGVPGFMGPPGNPG-PP 1203

Query: 168  KAPGVGGAFAGIPGV----GPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYGPG 223
             A G+ GA AG PG+    G  G P P  P G P     +PG  G     GK     GP 
Sbjct: 1204 GADGIAGA-AGPPGIQGSPGKEGPPGPQGPSGLP----GIPGEEGKEGRDGKP----GPP 1254

Query: 224  GVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIG 283
            G  G AG+ G P     GP+ A            +GA G     G  G+PG  G +PG  
Sbjct: 1255 GEPGKAGEPGLP-----GPEGARGPPGFKGHTGDSGAPGPRGESGAMGLPGQEG-LPGKD 1308

Query: 284  GIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA----------GVPG 333
            G  G   P             K G+     PG PG  PG  G PG           G+PG
Sbjct: 1309 GDTGPTGPQGPQGPRGPP--GKNGS-----PGSPG-EPGPSGTPGQKGSKGENGSPGLPG 1360

Query: 334  V----GVPGA-GIPVVPGA-GIPGA-AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPT 386
                 G PG  G   VPG  G+PG    PG                 G +   G  GIP 
Sbjct: 1361 FLGPRGPPGEPGEKGVPGKEGVPGKPGEPGFKGERGDPGIKGDKGPPGGKGQPGDPGIP- 1419

Query: 387  YGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGV-GISPEAQAAAAAKAAKYGLV 445
               G  G  G  +G  G+PG  G  G  G PG  G PG+ G SP  +        + G  
Sbjct: 1420 ---GHKGHTGL-MGPQGLPGENGPVGPPGPPGQPGFPGLRGESPSMETLRRLIQEELGKQ 1475

Query: 446  PGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPG-VGVAPGIGPGGVAAAAKSAAK 504
                +A  +   P   +    G  PG    PG    PG  G     G  G       +  
Sbjct: 1476 LETRLAYLLAQMPPAYMKSSQG-RPGPPGPPGKDGLPGRAGPMGEPGRPGQGGLEGPSGP 1534

Query: 505  VAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAA 564
            +  K +  A    GA   GL   +G PG+    G PG     G+PG              
Sbjct: 1535 IGPKGERGAKGDPGAPGVGLRGEMGPPGIPGQPGEPGYAKD-GLPG-------------- 1579

Query: 565  KYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLV 613
                 +PG  G  G  G  G+PG     G    +  A  A+ AA+ G V
Sbjct: 1580 -----IPGPQGETGPAGHPGLPGPPGPPGQCDPSQCAYFASLAARPGNV 1623



 Score =  105 bits (261), Expect = 2e-22
 Identities = 158/548 (28%), Positives = 182/548 (33%), Gaps = 102/548 (18%)

Query: 205  GGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGA-----G 259
            G  GLP   G +    G  G  GA G  G     G+GP        K +          G
Sbjct: 490  GPMGLPGPKGDI----GAIGPVGAPGPKGEKGDVGIGPFGQGEKGEKGSLGLPGPPGRDG 545

Query: 260  AAGVLPGVGGAGVPGVPGAI--------PGIGGIAG-VGTPAAAAAAAAAAKAAKYGAAA 310
            + G+    G  G PG+PG +        PG+ G  G VG P             + G   
Sbjct: 546  SKGMRGEPGELGEPGLPGEVGMRGPQGPPGLPGPPGRVGAPGLQGERGEKGTRGEKGER- 604

Query: 311  GL--VPGGPGFG-----PGVVGVPGAGVPGVGVPGAGIPVVPGAGIPGAAVPGVVSPEAA 363
            GL   PG PG       PG  GV G       V  AG P VPG+ +    + G       
Sbjct: 605  GLDGFPGKPGDTGQQGRPGPSGVAGPQGEKGDVGPAGPPGVPGSVVQQEGLKGEQGAPGP 664

Query: 364  AKAAAKAAKYGARPGVGVGGI--PTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGG 421
                      GAR  +G  G   P    G  G  G  +G  GIPG+ G+ G  G PGV G
Sbjct: 665  RGHQGAPGPPGARGPIGPEGRDGPPGLQGLRGKKG-DMGPPGIPGLLGLQGPPGPPGVPG 723

Query: 422  VPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVA 481
             PG G SP                PG    PG    PG     G    PG    PG    
Sbjct: 724  PPGPGGSPGLPGEIG--------FPGKPGPPGPTGPPGKDGPNGPPGPPGTKGEPGERGE 775

Query: 482  PGVGVAPG----IGPGGVAAAAKSAAKVAAKAQLRAAAGLGA--------------GIPG 523
             G+   PG    IG  G+A           +A L  A G                 G+PG
Sbjct: 776  DGLPGKPGLRGEIGEQGLAGRPGE----KGEAGLPGAPGFPGVRGEKGDQGEKGELGLPG 831

Query: 524  LGVGVGVPGLGVGAGVPGL-GVGA------------------------GVPGFGAVPGAL 558
            L    G  G    AG PGL G  +                        G PG    PG L
Sbjct: 832  LKGDRGEKGEAGPAGPPGLPGTTSLFTPHPRMPGEQGPKGEKGDPGLPGEPGLQGRPGEL 891

Query: 559  A--------AAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQF 610
                      AK  +     PG  G  GA G VG PG     G   A        K  + 
Sbjct: 892  GPQGPTGPPGAKGQEGAHGAPGAAGNPGAPGHVGAPGPSGPPGSVGAPGLRGTPGKDGER 951

Query: 611  GLVGAAGLGGL--GVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGACL 668
            G  GAAG  G    VG  G PG  GL G PP         G    PG   SP  PG    
Sbjct: 952  GEKGAAGEEGSPGPVGPRGDPGAPGLPG-PPGK-------GKDGEPGLRGSPGLPGPLGT 1003

Query: 669  GKACGRKR 676
              ACG+ R
Sbjct: 1004 KAACGKVR 1011



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 137/462 (29%), Positives = 165/462 (35%), Gaps = 77/462 (16%)

Query: 261 AGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAA----AAAAAAKAAKYGAAAGL-VPG 315
           AG    +G AG  G+PG    IG I  VG P                 + G    L +PG
Sbjct: 480 AGEKGEMGVAGPMGLPGPKGDIGAIGPVGAPGPKGEKGDVGIGPFGQGEKGEKGSLGLPG 539

Query: 316 GPG--FGPGVVGVPG----AGVPG-VGVPG----AGIPVVPG-AGIPG------------ 351
            PG     G+ G PG     G+PG VG+ G     G+P  PG  G PG            
Sbjct: 540 PPGRDGSKGMRGEPGELGEPGLPGEVGMRGPQGPPGLPGPPGRVGAPGLQGERGEKGTRG 599

Query: 352 ----------AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGV 401
                        PG    +     +  A   G +  VG  G P       G PG  V  
Sbjct: 600 EKGERGLDGFPGKPGDTGQQGRPGPSGVAGPQGEKGDVGPAGPP-------GVPGSVVQQ 652

Query: 402 GGIPGVAGVPGVGGVPGVGGVPGV--GISPEAQAAAAAKAAKYGL--------VPGVGVA 451
            G+ G  G PG  G  G  G PG    I PE +          G         +PG+   
Sbjct: 653 EGLKGEQGAPGPRGHQGAPGPPGARGPIGPEGRDGPPGLQGLRGKKGDMGPPGIPGLLGL 712

Query: 452 PGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG-IGPGGVAAAAKSAAKVAAKAQ 510
            G    PGV   PG G +PG+   PG    PG    PG  GP G             K +
Sbjct: 713 QGPPGPPGVPGPPGPGGSPGL---PGEIGFPGKPGPPGPTGPPGKDGPNGPPGPPGTKGE 769

Query: 511 --LRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALA--AAKAAKY 566
              R   GL  G PGL   +G  GL   AG PG    AG+PG    PG       +  K 
Sbjct: 770 PGERGEDGL-PGKPGLRGEIGEQGL---AGRPGEKGEAGLPGAPGFPGVRGEKGDQGEKG 825

Query: 567 GAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL-GVGG 625
              +PG+ G  G  G  G P G  G  P   +          + G  G  G  GL G  G
Sbjct: 826 ELGLPGLKGDRGEKGEAG-PAGPPGL-PGTTSLFTPHPRMPGEQGPKGEKGDPGLPGEPG 883

Query: 626 L-GVPGVGGLGGI--PPAAAAKAAKYGVAARPGFGLSPIFPG 664
           L G PG  G  G   PP A  +   +G    PG   +P  PG
Sbjct: 884 LQGRPGELGPQGPTGPPGAKGQEGAHGA---PGAAGNPGAPG 922


>gi|18105032 type X collagen alpha 1 precursor [Homo sapiens]
          Length = 680

 Score =  143 bits (361), Expect = 5e-34
 Identities = 167/524 (31%), Positives = 200/524 (38%), Gaps = 38/524 (7%)

Query: 117 AVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAF 176
           AV  + G    PG     G PG       PG   PG+   PG+P   G  P A G  G  
Sbjct: 54  AVRGEQGTPGPPGPAGPRGHPGPSGPPGKPGYGSPGLQGEPGLPGPPG--PSAVGKPGV- 110

Query: 177 AGIPGV----GPFGGPQPGVPLGYPIKAPK-LPGGYGLPYTTG-KLPYGYGPGGVAGAAG 230
            G+PG     GP+G      P G P   P+  PG  G+P   G  +P   G  G  GA G
Sbjct: 111 PGLPGKPGERGPYGPKGDVGPAGLP--GPRGPPGPPGIPGPAGISVPGKPGQQGPTGAPG 168

Query: 231 KAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGT 290
             G+P   G  P        K    +GA       G+ G   P  P   PG+G     G 
Sbjct: 169 PRGFPGEKG-APGVPGMNGQKGEMGYGAPGRPGERGLPGPQGPTGPSGPPGVGKRGENGV 227

Query: 291 PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPG-VGVPGAGIPVVPGA-G 348
           P             + G    + P GP   PG  G  G G PG  G PG   P +PG  G
Sbjct: 228 PGQPGIKGDRGFPGEMGP---IGPPGPQGPPGERGPEGIGKPGAAGAPGQ--PGIPGTKG 282

Query: 349 IPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVA 408
           +PGA  PG+  P        K    G +   G  G+P  G GA G  G   G+ G PG+ 
Sbjct: 283 LPGA--PGIAGP-PGPPGFGKPGLPGLKGERGPAGLPG-GPGAKGEQG-PAGLPGKPGLT 337

Query: 409 GVPGVGGVPGVGGVPGV-GISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVG 467
           G PG  G  G  G+PG  G+         A  A Y    G   +PG    PG    PG+ 
Sbjct: 338 GPPGNMGPQGPKGIPGSHGLPGPKGETGPAGPAGYPGAKGERGSPGSDGKPGYPGKPGLD 397

Query: 468 LAPGVGVAPGVGVAPGVGVAPGI-GPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGV 526
              G    PG    PGVG  PG+ GP G  A AK       +A  R A     GIPG   
Sbjct: 398 GPKGNPGLPGPKGDPGVGGPPGLPGPVG-PAGAKGMPGHNGEAGPRGA----PGIPGTRG 452

Query: 527 GVGVPGLGVGAGVPGLGVGAGVPGFGAVPG-ALAAAKAAKYGAAVPGVLGGLGALGGVGI 585
            +G P      G+PG     G PG    PG A  A K        PG  G  G  G  G+
Sbjct: 453 PIGPP------GIPGFPGSKGDPGSPGPPGPAGIATKGLNGPTGPPGPPGPRGHSGEPGL 506

Query: 586 PGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVP 629
           PG     GP   A   +   KA Q   +    L     G  G+P
Sbjct: 507 PGPPGPPGPPGQAVMPEGFIKAGQRPSLSGTPLVSANQGVTGMP 550



 Score =  123 bits (308), Expect = 6e-28
 Identities = 161/530 (30%), Positives = 192/530 (36%), Gaps = 110/530 (20%)

Query: 23  PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALV 82
           P+ P G PG  P G PG   Y + G  G+P  P P G +  G   G+   P    PG   
Sbjct: 67  PAGPRGHPG--PSGPPGKPGYGSPGLQGEPGLPGPPGPSAVGK-PGVPGLPGK--PGERG 121

Query: 83  PGGVAD--AAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVY 140
           P G       A     +   G  G+PG  G+ V        PG   KPG+    G PG  
Sbjct: 122 PYGPKGDVGPAGLPGPRGPPGPPGIPGPAGISV--------PG---KPGQQGPTGAPG-- 168

Query: 141 PGGVLPGARFPGVGVLPGVPTGAGVKPK----APGVGGAFAGIPG----VGPFGGP---- 188
           P G      FPG    PGVP   G K +    APG  G   G+PG     GP G P    
Sbjct: 169 PRG------FPGEKGAPGVPGMNGQKGEMGYGAPGRPGE-RGLPGPQGPTGPSGPPGVGK 221

Query: 189 --------QPGVP--LGYPIKAPKL--PGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPT 236
                   QPG+    G+P +   +  PG  G P   G  P G G  G AGA G+ G P 
Sbjct: 222 RGENGVPGQPGIKGDRGFPGEMGPIGPPGPQGPPGERG--PEGIGKPGAAGAPGQPGIPG 279

Query: 237 GTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAA 296
             G+ P A   A                PG G  G+PG+ G     G   G G       
Sbjct: 280 TKGL-PGAPGIAGPPGP-----------PGFGKPGLPGLKGERGPAGLPGGPGAKGEQGP 327

Query: 297 AAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG----------AGVPGV----GVPGA--- 339
           A    K    G    + P GP   PG  G+PG          AG PG     G PG+   
Sbjct: 328 AGLPGKPGLTGPPGNMGPQGPKGIPGSHGLPGPKGETGPAGPAGYPGAKGERGSPGSDGK 387

Query: 340 -GIPVVPG-------AGIPG-------AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGI 384
            G P  PG        G+PG          PG+  P   A A       G     G  GI
Sbjct: 388 PGYPGKPGLDGPKGNPGLPGPKGDPGVGGPPGLPGPVGPAGAKGMPGHNGEAGPRGAPGI 447

Query: 385 P-TYG-VGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKY 442
           P T G +G  G PGF       PG  G PG  G PG  G+   G++             +
Sbjct: 448 PGTRGPIGPPGIPGF-------PGSKGDPGSPGPPGPAGIATKGLNGPTGPPGPPGPRGH 500

Query: 443 GLVPGVGVAPGVGVAPGVGVAP----GVGLAPGVGVAPGVGVAPGVGVAP 488
              PG+   PG    PG  V P      G  P +   P V    GV   P
Sbjct: 501 SGEPGLPGPPGPPGPPGQAVMPEGFIKAGQRPSLSGTPLVSANQGVTGMP 550



 Score =  111 bits (277), Expect = 2e-24
 Identities = 148/482 (30%), Positives = 176/482 (36%), Gaps = 86/482 (17%)

Query: 183 GPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGY----GPGGVAGAAGKAGYPTGT 238
           G F   +  +P G     P     + +PYT            G  G  G AG  G+P   
Sbjct: 18  GVFYAERYQMPTGIKGPLPNTKTQFFIPYTIKSKGIAVRGEQGTPGPPGPAGPRGHP--- 74

Query: 239 GVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAA 298
             GP               +G  G  PG G  G+ G PG +PG  G + VG P       
Sbjct: 75  --GP---------------SGPPGK-PGYGSPGLQGEPG-LPGPPGPSAVGKPGVPGLPG 115

Query: 299 AAAKAAKYGAAAGLVPGG---PGFGPGVVGVPG-AGVPGVGVPGAGIPV-VPGA-GIPGA 352
              +   YG    + P G   P   PG  G+PG AG+   G PG   P   PG  G PG 
Sbjct: 116 KPGERGPYGPKGDVGPAGLPGPRGPPGPPGIPGPAGISVPGKPGQQGPTGAPGPRGFPGE 175

Query: 353 -AVPGVVSPEAAAKAAAKAAKYGA--RPGV-GVGGIPTYGVGAGGFPGFGV-GVGGIPGV 407
              PGV               YGA  RPG  G+ G P    G  G PG G  G  G+PG 
Sbjct: 176 KGAPGVPGMNGQKGEMG----YGAPGRPGERGLPG-PQGPTGPSGPPGVGKRGENGVPGQ 230

Query: 408 AGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVG 467
            G+ G  G PG  G  G    P  Q     +  +     G+G  PG   APG    PG  
Sbjct: 231 PGIKGDRGFPGEMGPIG---PPGPQGPPGERGPE-----GIG-KPGAAGAPGQPGIPGTK 281

Query: 468 LAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVG 527
             PG   APG+   PG    PG G  G+               L+   G  AG+PG   G
Sbjct: 282 GLPG---APGIAGPPG---PPGFGKPGLPG-------------LKGERG-PAGLPG---G 318

Query: 528 VGVPGLGVGAGVPGLGVGAGVPGFGAVPGALA--AAKAAKYGAAVPGVLGGLGALGGVGI 585
            G  G    AG+PG       PG    PG +     K       +PG  G  G  G  G 
Sbjct: 319 PGAKGEQGPAGLPGK------PGLTGPPGNMGPQGPKGIPGSHGLPGPKGETGPAGPAGY 372

Query: 586 PGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKA 645
           PG     G   +        K    GL G  G  GL  G  G PGVGG  G+P       
Sbjct: 373 PGAKGERGSPGSDGKPGYPGKP---GLDGPKGNPGLP-GPKGDPGVGGPPGLPGPVGPAG 428

Query: 646 AK 647
           AK
Sbjct: 429 AK 430



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 93/301 (30%), Positives = 110/301 (36%), Gaps = 67/301 (22%)

Query: 400 GVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPG 459
           G  G PG  G  G  G PG  G PG                 YG  PG+   PG+   PG
Sbjct: 57  GEQGTPGPPGPAGPRGHPGPSGPPG--------------KPGYG-SPGLQGEPGLPGPPG 101

Query: 460 VGVA--PGVGLAPG-------------VGVA--PGVGVAPGVGVAPGI-GPGGVAAAAKS 501
                 PGV   PG             VG A  PG    PG    PGI GP G++   K 
Sbjct: 102 PSAVGKPGVPGLPGKPGERGPYGPKGDVGPAGLPGPRGPPG---PPGIPGPAGISVPGKP 158

Query: 502 AAK--VAAKAQLRAAAGLGA-GIPGLG-----VGVGVPGLGVGAGVPGL--------GVG 545
             +    A          GA G+PG+      +G G PG     G+PG           G
Sbjct: 159 GQQGPTGAPGPRGFPGEKGAPGVPGMNGQKGEMGYGAPGRPGERGLPGPQGPTGPSGPPG 218

Query: 546 AGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPG--GVVGAGPAAAAAAAKA 603
            G  G   VPG        K     PG +G +G  G  G PG  G  G G   AA A   
Sbjct: 219 VGKRGENGVPG----QPGIKGDRGFPGEMGPIGPPGPQGPPGERGPEGIGKPGAAGAPGQ 274

Query: 604 AAKAAQFGLVGAAGLGG-LGVGGLGVPGVGGL------GGIP--PAAAAKAAKYGVAARP 654
                  GL GA G+ G  G  G G PG+ GL       G+P  P A  +    G+  +P
Sbjct: 275 PGIPGTKGLPGAPGIAGPPGPPGFGKPGLPGLKGERGPAGLPGGPGAKGEQGPAGLPGKP 334

Query: 655 G 655
           G
Sbjct: 335 G 335



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 66/226 (29%), Positives = 77/226 (34%), Gaps = 45/226 (19%)

Query: 445 VPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGI-GPGGVAAAAKSAA 503
           V G    PG     G    PG    PG    PG G +PG+   PG+ GP G +A  K   
Sbjct: 55  VRGEQGTPGPPGPAGPRGHPGPSGPPG---KPGYG-SPGLQGEPGLPGPPGPSAVGKPGV 110

Query: 504 KVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKA 563
                           G+PG     G  G     G  GL    G PG   +PG    +  
Sbjct: 111 P---------------GLPGKPGERGPYGPKGDVGPAGLPGPRGPPGPPGIPGPAGISVP 155

Query: 564 AKYGAAVPGVLGGLGALGGVGIPG-----GVVGAGPAAAAAAAKAAAKAAQFGLVGAAGL 618
            K     PG  G  GA G  G PG     GV G           A  +  + GL G  G 
Sbjct: 156 GK-----PGQQGPTGAPGPRGFPGEKGAPGVPGMNGQKGEMGYGAPGRPGERGLPGPQG- 209

Query: 619 GGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
                G  G PGVG           K  + GV  +PG      FPG
Sbjct: 210 ---PTGPSGPPGVG-----------KRGENGVPGQPGIKGDRGFPG 241


>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
          Length = 2944

 Score =  139 bits (351), Expect = 7e-33
 Identities = 213/673 (31%), Positives = 249/673 (36%), Gaps = 106/673 (15%)

Query: 26   PGGVPGAI-PGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPG 84
            P G PG   P G PG V     G  G P  P   G AG    +GL   P  T P    PG
Sbjct: 2163 PEGKPGLQGPRGPPGPV--GGHGDPGPPGAPGLAGPAGPQGPSGLKGEPGETGP----PG 2216

Query: 85   -GVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPG- 142
             G+     A        GL G PG  GL      V PQ   G+ PG+V   G PG  PG 
Sbjct: 2217 RGLTGPTGA-------VGLPGPPGPSGL------VGPQGSPGL-PGQVGETGKPGA-PGR 2261

Query: 143  ----GVLPGARFPGVGVLPGVPTGAGVK--PKAPGVGG-AFAGIPGVGPFGGPQPGVPLG 195
                G       PGV   PG+P   G K  P   G  G A  G+PG     G  PG   G
Sbjct: 2262 DGASGKDGDRGSPGVPGSPGLPGPVGPKGEPGPTGAPGQAVVGLPGAKGEKGA-PGGLAG 2320

Query: 196  YPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAK 255
              +  P   G  GLP          GP G  G AG+AG P   G   Q  A         
Sbjct: 2321 DLVGEPGAKGDRGLP----------GPRGEKGEAGRAGEPGDPGEDGQKGAPGPKGFKGD 2370

Query: 256  FGAGAAGVL-----PGV-GGAGVPGVPGAIPGIGGIAG-------VGTPAAAAAAAAAAK 302
             G G  G       PGV G  G+PG+PGA PG+ G  G       +G P  +     A  
Sbjct: 2371 PGVGVPGSPGPPGPPGVKGDLGLPGLPGA-PGVVGFPGQTGPRGEMGQPGPSGERGLAGP 2429

Query: 303  AAKYGAAAGLVPGGPGFGPGVVGVPGA-------GVPGVGVPGA----GIPVVPGA-GIP 350
              + G    L P GP   PG VG PGA       G PGVG+PG     G P + G  G P
Sbjct: 2430 PGREGIPGPLGPPGP---PGSVGPPGASGLKGDKGDPGVGLPGPRGERGEPGIRGEDGRP 2486

Query: 351  GAAVP-GVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAG 409
            G   P G+  P  +     +    G+    G  G     +G  G P    G  G  G  G
Sbjct: 2487 GQEGPRGLTGPPGSRGERGEKGDVGSAGLKGDKGDSAVILGPPG-PRGAKGDMGERGPRG 2545

Query: 410  VPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLA 469
            + G  G  G  G PG     +            GL PG+    G    PG    PG   +
Sbjct: 2546 LDGDKGPRGDNGDPG----DKGSKGEPGDKGSAGL-PGLRGLLGPQGQPGAAGIPGDPGS 2600

Query: 470  PGVGVAPGV-GVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGA--GIPGLGV 526
            PG    PG+ G    VG    +GP G+            +  ++ A GL    G  G   
Sbjct: 2601 PGKDGVPGIRGEKGDVGF---MGPRGLKG----------ERGVKGACGLDGEKGDKGEAG 2647

Query: 527  GVGVPGLGVGAGVPGLGVGAGVPGFGAVPG--ALAAAKAAKYGAAVPGVLGGLGALGGVG 584
              G PGL   AG  G     GVPG    PG   L   K  +     PG  G  G  G  G
Sbjct: 2648 PPGRPGL---AGHKGEMGEPGVPGQSGAPGKEGLIGPKGDRGFDGQPGPKGDQGEKGERG 2704

Query: 585  IPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPG--VGGLGGIPPAAA 642
             PG     GP+    +A         G  G  GL G   G  G PG  V G  G+P A  
Sbjct: 2705 TPGIGGFPGPSGNDGSAGPPGPPGSVGPRGPEGLQG-QKGERGPPGERVVGAPGVPGAPG 2763

Query: 643  AKAAKYGVAARPG 655
             +    G   RPG
Sbjct: 2764 ER----GEQGRPG 2772



 Score =  134 bits (336), Expect = 4e-31
 Identities = 214/684 (31%), Positives = 252/684 (36%), Gaps = 134/684 (19%)

Query: 28   GVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVA 87
            G PG  P G PG     ALG  G P    P GLAG     G+   P          GGV 
Sbjct: 2009 GDPG--PQGPPG----LALGERGPP---GPSGLAGEPGKPGIPGLPGRA-------GGVG 2052

Query: 88   DAAAAYKAAKAGA-------GLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVY 140
            +A    +  + G        G  G PG+ G           PG    PG    V  PG  
Sbjct: 2053 EAGRPGERGERGEKGERGEQGRDGPPGLPGT----------PGPPGPPGPKVSVDEPG-- 2100

Query: 141  PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFA--GIPGV-GPFGGPQPGVPLGYP 197
            PG  L G + P     PG+  GA  +P + G  G     G+PG+ G  G P P    G P
Sbjct: 2101 PG--LSGEQGP-----PGLK-GAKGEPGSNGDQGPKGDRGVPGIKGDRGEPGPRGQDGNP 2152

Query: 198  IKAPKLPGGYGLPYTTGK--LPYGYGPGGVAGAAGKAGYPTGTGV----GPQAAAAAAAK 251
                 LPG  G+    GK  L    GP G  G  G  G P   G+    GPQ  +    +
Sbjct: 2153 ----GLPGERGMAGPEGKPGLQGPRGPPGPVGGHGDPGPPGAPGLAGPAGPQGPSGLKGE 2208

Query: 252  AAAKFGAGAAGVLPGVGGAGVPGVPG--------AIPGIGGIAG-VGTPAAAAAAAAAAK 302
               + G    G+    G  G+PG PG          PG+ G  G  G P A     A+ K
Sbjct: 2209 PG-ETGPPGRGLTGPTGAVGLPGPPGPSGLVGPQGSPGLPGQVGETGKPGAPGRDGASGK 2267

Query: 303  AAKYGAAAGLVPGGPGFGPGVVGVPG----AGVPG---VGVPGA-GIPVVPG------AG 348
                G+    VPG PG  PG VG  G     G PG   VG+PGA G    PG       G
Sbjct: 2268 DGDRGSPG--VPGSPGL-PGPVGPKGEPGPTGAPGQAVVGLPGAKGEKGAPGGLAGDLVG 2324

Query: 349  IPGA-AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGF-GVGVGGIPG 406
             PGA    G+  P      A +A + G     G  G P    G  GF G  GVGV G PG
Sbjct: 2325 EPGAKGDRGLPGPRGEKGEAGRAGEPGDPGEDGQKGAP----GPKGFKGDPGVGVPGSPG 2380

Query: 407  VAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGV 466
              G PGV G  G+ G+PG                     PGV   PG     G    PG 
Sbjct: 2381 PPGPPGVKGDLGLPGLPG--------------------APGVVGFPGQTGPRGEMGQPGP 2420

Query: 467  GLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGV 526
                G+   PG    PG    PG  PG V     S  K             G G+PG   
Sbjct: 2421 SGERGLAGPPGREGIPGPLGPPG-PPGSVGPPGASGLK-------GDKGDPGVGLPGPRG 2472

Query: 527  GVGVPGLGVGAGVPGLGVGAGVPGFGAVPG--------ALAAAKAAKYGAAV----PGVL 574
              G PG+    G PG     G+ G     G          A  K  K  +AV    PG  
Sbjct: 2473 ERGEPGIRGEDGRPGQEGPRGLTGPPGSRGERGEKGDVGSAGLKGDKGDSAVILGPPGPR 2532

Query: 575  GGLGALGGVGIPGGVVG-AGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGG 633
            G  G +G  G P G+ G  GP              + G  G+AGL GL  G LG  G  G
Sbjct: 2533 GAKGDMGERG-PRGLDGDKGPRGDNGDPGDKGSKGEPGDKGSAGLPGLR-GLLGPQGQPG 2590

Query: 634  LGGIP--PAAAAKAAKYGVAARPG 655
              GIP  P +  K    G+    G
Sbjct: 2591 AAGIPGDPGSPGKDGVPGIRGEKG 2614



 Score =  130 bits (326), Expect = 5e-30
 Identities = 215/720 (29%), Positives = 255/720 (35%), Gaps = 141/720 (19%)

Query: 23   PSRPGGVPG--AIPG--GVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFP 78
            PS   G PG   IPG  G  GGV     G  G+P +    G  G     G    P +  P
Sbjct: 2029 PSGLAGEPGKPGIPGLPGRAGGV-----GEAGRPGERGERGEKGERGEQGRDGPPGL--P 2081

Query: 79   GALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPG 138
            G   PG            + G GL G  G  GL  + G    +PG+    G     G+PG
Sbjct: 2082 GT--PGPPGPPGPKVSVDEPGPGLSGEQGPPGLKGAKG----EPGSNGDQGPKGDRGVPG 2135

Query: 139  VYPGGVLPGARFP-GVGVLPGVPTGAGVKPKAPGVGGAFAGIPG-VGPFGGP-QPGVPLG 195
            +      PG R   G   LPG    AG + K PG+ G   G PG VG  G P  PG P  
Sbjct: 2136 IKGDRGEPGPRGQDGNPGLPGERGMAGPEGK-PGLQGP-RGPPGPVGGHGDPGPPGAPGL 2193

Query: 196  YPIKAPKLPGGY-GLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTG-VGPQAA------AA 247
                 P+ P G  G P  TG  P G G  G  GA G  G P  +G VGPQ +        
Sbjct: 2194 AGPAGPQGPSGLKGEPGETG--PPGRGLTGPTGAVGLPGPPGPSGLVGPQGSPGLPGQVG 2251

Query: 248  AAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAG----VGTPAAAAAAAAAAKA 303
               K  A    GA+G     G  GVPG PG +PG  G  G     G P  A      AK 
Sbjct: 2252 ETGKPGAPGRDGASGKDGDRGSPGVPGSPG-LPGPVGPKGEPGPTGAPGQAVVGLPGAKG 2310

Query: 304  AKYGAAAGLV------------------------------PGGPGFGPGVVGVPGA---- 329
             K GA  GL                               PG PG   G  G PG     
Sbjct: 2311 EK-GAPGGLAGDLVGEPGAKGDRGLPGPRGEKGEAGRAGEPGDPG-EDGQKGAPGPKGFK 2368

Query: 330  GVPGVGVPGA-GIPVVPGA-------GIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGV 381
            G PGVGVPG+ G P  PG        G+PGA  PGVV          +  + G     G+
Sbjct: 2369 GDPGVGVPGSPGPPGPPGVKGDLGLPGLPGA--PGVVGFPGQTGPRGEMGQPGPSGERGL 2426

Query: 382  GGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGI-SPEAQAAAAAKAA 440
             G P    G  G PG  +G  G PG  G PG  G+ G  G PGVG+  P  +        
Sbjct: 2427 AGPP----GREGIPG-PLGPPGPPGSVGPPGASGLKGDKGDPGVGLPGPRGERGEPGIRG 2481

Query: 441  KYGLVPGVGVAPGVGVAPGV-------GVAPGVGLAPGVGVAPGVGVAPGVGVAPGI--- 490
            + G  PG     G+   PG        G     GL    G +  +   PG   A G    
Sbjct: 2482 EDGR-PGQEGPRGLTGPPGSRGERGEKGDVGSAGLKGDKGDSAVILGPPGPRGAKGDMGE 2540

Query: 491  -GPGGVAAAAKSAAKVAAKAQLRAAAGLG----AGIPGLGVGVGVPGLGVGAGVPGLGVG 545
             GP G+                 +    G    AG+PGL   +G  G    AG+PG    
Sbjct: 2541 RGPRGLDGDKGPRGDNGDPGDKGSKGEPGDKGSAGLPGLRGLLGPQGQPGAAGIPG---D 2597

Query: 546  AGVPGFGAVPG--------------ALAAAKAAKYGAAV---------------PGVLGG 576
             G PG   VPG               L   +  K    +               PG+ G 
Sbjct: 2598 PGSPGKDGVPGIRGEKGDVGFMGPRGLKGERGVKGACGLDGEKGDKGEAGPPGRPGLAGH 2657

Query: 577  LGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGG 636
             G +G  G+PG     G               Q G  G  G      G  G PG+GG  G
Sbjct: 2658 KGEMGEPGVPGQSGAPGKEGLIGPKGDRGFDGQPGPKGDQG----EKGERGTPGIGGFPG 2713



 Score =  122 bits (306), Expect = 1e-27
 Identities = 207/734 (28%), Positives = 255/734 (34%), Gaps = 138/734 (18%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYPA-LGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTF---- 77
            P+ P G  G      P G+  P   GP G P    P GL G     G    P        
Sbjct: 1561 PAGPRGATGVQGERGPPGLVLPGDPGPKGDPGDRGPIGLTGRAGPPGDSGPPGEKGDPGR 1620

Query: 78   ---PGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGV 134
               PG + P G  D     K  +   G  G+PG  G     GA    PG     G+    
Sbjct: 1621 PGPPGPVGPRG-RDGEVGEKGDEGPPGDPGLPGKAGERGLRGA----PGVRGPVGEKGDQ 1675

Query: 135  GLPGVYPGGVLPGARFP----GVGVLPGVP-----TGAGVKPKA---------------- 169
            G PG       PG+  P    G    PG P     TG G + K                 
Sbjct: 1676 GDPGEDGRNGSPGSSGPKGDRGEPGPPGPPGRLVDTGPGAREKGEPGDRGQEGPRGPKGD 1735

Query: 170  PGVGGAFAGIPGVGPFGGPQPGVPLGYP-IKAPK-------LPGGYGLPYTTGKLPYGYG 221
            PG+ GA  G  G+  F GP PG P G P ++ P         PG  G     GK P   G
Sbjct: 1736 PGLPGA-PGERGIEGFRGP-PG-PQGDPGVRGPAGEKGDRGPPGLDGRSGLDGK-PGAAG 1791

Query: 222  PGGVAGAAGKAGYPTGTGV----GPQAAAAAAAKAAAKFGAGAAGVLPGVGGA-GVPGVP 276
            P G  GAAGKAG P   G+    G Q     +         G  G  PG+ G  G PG P
Sbjct: 1792 PSGPNGAAGKAGDPGRDGLPGLRGEQGLPGPSGPPGLPGKPGEDGK-PGLNGKNGEPGDP 1850

Query: 277  GAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGAGVPGV-- 334
            G     G     G   A+          + GA   L P GP   PG VG PG G PGV  
Sbjct: 1851 GED---GRKGEKGDSGASGREGRDGPKGERGAPGILGPQGPPGLPGPVGPPGQGFPGVPG 1907

Query: 335  -----------------GVPG-AGIPVVPG-----------AGIPGAAVPGVVS------ 359
                             G+PG  G+   PG           AGI  +A+  +V       
Sbjct: 1908 GTGPKGDRGETGSKGEQGLPGERGLRGEPGSVPNVDRLLETAGIKASALREIVETWDESS 1967

Query: 360  ------PEAAAKAAAKAAKYGARPGVGVGGIP--------TYGVGAGGFPGFGVGVGGIP 405
                  PE        + + G     G  G P            G  G PG  +G  G P
Sbjct: 1968 GSFLPVPERRRGPKGDSGEQGPPGKEGPIGFPGERGLKGDRGDPGPQGPPGLALGERGPP 2027

Query: 406  GVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPG 465
            G +G+ G  G PG+ G+PG       +A    +A + G   G     G     G    PG
Sbjct: 2028 GPSGLAGEPGKPGIPGLPG-------RAGGVGEAGRPG-ERGERGEKGERGEQGRDGPPG 2079

Query: 466  VGLAPGVGVAPGVGVA---PGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIP 522
            +   PG    PG  V+   PG G++   GP G+  A         +           G+P
Sbjct: 2080 LPGTPGPPGPPGPKVSVDEPGPGLSGEQGPPGLKGAKGEPGSNGDQGPKG-----DRGVP 2134

Query: 523  GLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGG 582
            G+    G PG     G PGL    G+ G    PG              PG +GG G  G 
Sbjct: 2135 GIKGDRGEPGPRGQDGNPGLPGERGMAGPEGKPGLQGP-------RGPPGPVGGHGDPGP 2187

Query: 583  VGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGL-GVPGVGGLGGIPPAA 641
             G PG    AGPA     +    +  + G  G    G  G  GL G PG  GL G P  +
Sbjct: 2188 PGAPG---LAGPAGPQGPSGLKGEPGETGPPGRGLTGPTGAVGLPGPPGPSGLVG-PQGS 2243

Query: 642  AAKAAKYGVAARPG 655
                 + G   +PG
Sbjct: 2244 PGLPGQVGETGKPG 2257



 Score =  121 bits (303), Expect = 2e-27
 Identities = 205/663 (30%), Positives = 237/663 (35%), Gaps = 113/663 (17%)

Query: 44   PALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGAGLG 103
            P   P G+  +P   GL G     G    P  T  GA  P G   +A A K  +   G  
Sbjct: 1248 PVYCPKGQKGEPGEMGLRGQVGPPGDPGLPGRT--GAPGPQGPPGSATA-KGERGFPGAD 1304

Query: 104  GVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGA 163
            G PG  G   + G     PGA   PG     GLPG  P G  PG R P          G 
Sbjct: 1305 GRPGSPGRAGNPGT----PGA---PGLKGSPGLPG--PRGD-PGERGP---------RGP 1345

Query: 164  GVKPKAPG--VGGAFAGIPG----VGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKL- 216
              +P APG  +GG   G+PG     GP G P P  PLG P   P+ P G  LP T  K  
Sbjct: 1346 KGEPGAPGQVIGGEGPGLPGRKGDPGPSGPPGPRGPLGDP--GPRGPPG--LPGTAMKGD 1401

Query: 217  --------PYGYGPGGVA-GAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGA--GAAGVLP 265
                    P G G GG+A G  G  G P   G  PQ       K   K  +  GA G LP
Sbjct: 1402 KGDRGERGPPGPGEGGIAPGEPGLPGLPGSPG--PQGPVGPPGKKGEKGDSEDGAPG-LP 1458

Query: 266  G----------------VGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAA 309
            G                +G  G  G PG +   G     G P  A +      A + GA 
Sbjct: 1459 GQPGSPGEQGPRGPPGAIGPKGDRGFPGPLGEAGEKGERGPPGPAGSRGLPGVAGRPGAK 1518

Query: 310  AGLVPGGPGFGPGVVGVPGAGVPGVGVPGAGIPVVPGAGIPG-AAVPGVVSPEAAAKAAA 368
                P GP    G  G PG           G P V G  + G     G V P     A  
Sbjct: 1519 GPEGPPGPTGRQGEKGEPGR---------PGDPAVVGPAVAGPKGEKGDVGPAGPRGATG 1569

Query: 369  KAAKYGARPGVGVGGIPTYGVGAGGFPG----FGV-GVGGIPGVAGVPGVGGVPGVGGVP 423
               + G  PG+ + G P    G  G PG     G+ G  G PG +G PG  G PG  G P
Sbjct: 1570 VQGERGP-PGLVLPGDP----GPKGDPGDRGPIGLTGRAGPPGDSGPPGEKGDPGRPGPP 1624

Query: 424  GVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPG 483
            G  + P  +     +    G  PG    PG     G+  APGV    G     G     G
Sbjct: 1625 G-PVGPRGRDGEVGEKGDEG-PPGDPGLPGKAGERGLRGAPGVRGPVGEKGDQGDPGEDG 1682

Query: 484  VGVAPG-IGPGGVAAAAKSAAKVAAKAQLRAAAGLGA---GIPGLGVGVGVPGLGVGAGV 539
               +PG  GP G                     G GA   G PG     G  G     G+
Sbjct: 1683 RNGSPGSSGPKGDRGEPGPPGPPGRLVD----TGPGAREKGEPGDRGQEGPRGPKGDPGL 1738

Query: 540  PGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPG-----GVVGAGP 594
            PG     G+ GF   PG              PGV G  G  G  G PG     G+ G   
Sbjct: 1739 PGAPGERGIEGFRGPPGP----------QGDPGVRGPAGEKGDRGPPGLDGRSGLDGKPG 1788

Query: 595  AAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIP--PAAAAKAAKYGVAA 652
            AA  +    AA  A  G  G  GL GL  G  G+PG  G  G+P  P    K    G   
Sbjct: 1789 AAGPSGPNGAAGKA--GDPGRDGLPGLR-GEQGLPGPSGPPGLPGKPGEDGKPGLNGKNG 1845

Query: 653  RPG 655
             PG
Sbjct: 1846 EPG 1848



 Score =  112 bits (281), Expect = 9e-25
 Identities = 217/742 (29%), Positives = 255/742 (34%), Gaps = 133/742 (17%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALV 82
            P  P G PGA PG V GG      GPG    K  PG     G    LG       PG   
Sbjct: 1342 PRGPKGEPGA-PGQVIGGE-----GPGLPGRKGDPGPSGPPGPRGPLGD------PGPRG 1389

Query: 83   PGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVY-- 140
            P G+     A K  K   G  G PG G  G++ G     PG    PG    VG PG    
Sbjct: 1390 PPGLP--GTAMKGDKGDRGERGPPGPGEGGIAPGEP-GLPGLPGSPGPQGPVGPPGKKGE 1446

Query: 141  PGGVLPGARFPGVGVLPGVPTGAGVK--PKAPGVGGAFAGIPG-VGPFGGPQPGVPLGYP 197
             G    GA  PG+   PG P   G +  P A G  G   G PG +G  G      P G P
Sbjct: 1447 KGDSEDGA--PGLPGQPGSPGEQGPRGPPGAIGPKGD-RGFPGPLGEAGEKGERGPPG-P 1502

Query: 198  IKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFG 257
              +  LPG  G P   G      GP G  G  G+ G P   G       A A     K  
Sbjct: 1503 AGSRGLPGVAGRPGAKGP----EGPPGPTGRQGEKGEPGRPGDPAVVGPAVAGPKGEKGD 1558

Query: 258  AGAAGVLPGVGGAGVPGVPGAI----PGIGGIAG----VGTPAAAAAAAAAAKAAKYGAA 309
             G AG     G  G  G PG +    PG  G  G    +G    A     +    + G  
Sbjct: 1559 VGPAGPRGATGVQGERGPPGLVLPGDPGPKGDPGDRGPIGLTGRAGPPGDSGPPGEKGDP 1618

Query: 310  AGLVPGGPGFGP----------GVVGVPG-AGVPGV-------GVPGAGIPVV------- 344
                P GP  GP          G  G PG  G+PG        G PG   PV        
Sbjct: 1619 GRPGPPGP-VGPRGRDGEVGEKGDEGPPGDPGLPGKAGERGLRGAPGVRGPVGEKGDQGD 1677

Query: 345  PGA----GIPGAA-------VPGVVSPEAAAKAAAKAAKYGARPG----------VGVGG 383
            PG     G PG++        PG   P          A+    PG           G  G
Sbjct: 1678 PGEDGRNGSPGSSGPKGDRGEPGPPGPPGRLVDTGPGAREKGEPGDRGQEGPRGPKGDPG 1737

Query: 384  IPTYGVGAGGFPGF----------GV-GVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQ 432
            +P    G  G  GF          GV G  G  G  G PG+ G  G+ G PG    P   
Sbjct: 1738 LPG-APGERGIEGFRGPPGPQGDPGVRGPAGEKGDRGPPGLDGRSGLDGKPGAA-GPSGP 1795

Query: 433  AAAAAKAAKYGL--VPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGI 490
              AA KA   G   +PG+    G+   PG    PG+   PG    PG+    G    PG 
Sbjct: 1796 NGAAGKAGDPGRDGLPGLRGEQGL---PGPSGPPGLPGKPGEDGKPGLNGKNGEPGDPGE 1852

Query: 491  ----GPGGVAAAAKSAAKVAAKAQLRAAAGLGA-GIPGLGVGVGVPGLGVGAGVPGLGVG 545
                G  G + A+    +   K +  A   LG  G PGL   VG PG G   GVPG G G
Sbjct: 1853 DGRKGEKGDSGASGREGRDGPKGERGAPGILGPQGPPGLPGPVGPPGQGF-PGVPG-GTG 1910

Query: 546  A-------------GVPGF-------GAVPGALAAAKAAKYGA-AVPGVLGGLGALGGVG 584
                          G+PG        G+VP      + A   A A+  ++       G  
Sbjct: 1911 PKGDRGETGSKGEQGLPGERGLRGEPGSVPNVDRLLETAGIKASALREIVETWDESSGSF 1970

Query: 585  IPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAK 644
            +P      GP   +       K    G  G  GL G      G PG  G  G+       
Sbjct: 1971 LPVPERRRGPKGDSGEQGPPGKEGPIGFPGERGLKG----DRGDPGPQGPPGLALGERGP 2026

Query: 645  AAKYGVAARPGFGLSPIFPGGA 666
                G+A  PG    P  PG A
Sbjct: 2027 PGPSGLAGEPGKPGIPGLPGRA 2048



 Score =  103 bits (256), Expect = 7e-22
 Identities = 179/574 (31%), Positives = 207/574 (36%), Gaps = 146/574 (25%)

Query: 23   PSRPGGVPGAIPG--GVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGL-GAFPAVTFPG 79
            P  P G+ G  PG  G PG       G  G P  P P GL G     GL G       PG
Sbjct: 2199 PQGPSGLKGE-PGETGPPGRGLTGPTGAVGLPGPPGPSGLVGPQGSPGLPGQVGETGKPG 2257

Query: 80   ALVPGGVADAAAAYKAAKAGAGLGGVPGVGG----------LGVSAGAVVPQPGA-GVK- 127
            A  PG   D A+     +   G+ G PG+ G           G    AVV  PGA G K 
Sbjct: 2258 A--PG--RDGASGKDGDRGSPGVPGSPGLPGPVGPKGEPGPTGAPGQAVVGLPGAKGEKG 2313

Query: 128  -PGKVPG--VGLPGVYPGGVLPGARFP----GVGVLPGVPTGAGVKPKAPGVGGAFAGIP 180
             PG + G  VG PG      LPG R      G    PG P   G K  APG  G F G P
Sbjct: 2314 APGGLAGDLVGEPGAKGDRGLPGPRGEKGEAGRAGEPGDPGEDGQKG-APGPKG-FKGDP 2371

Query: 181  GVGPFGGPQPGVP------LGYPIKAPKLPGGYGLPYTTGKL-----PYGYGPGGVAGAA 229
            GVG  G P P  P      LG P   P  PG  G P  TG       P   G  G+AG  
Sbjct: 2372 GVGVPGSPGPPGPPGVKGDLGLP-GLPGAPGVVGFPGQTGPRGEMGQPGPSGERGLAGPP 2430

Query: 230  GKAGYPTGTGV-GPQAAAAAAAKAAAKFGAGAAGV-LPGVGGA-GVPGVPG--AIPGIGG 284
            G+ G P   G  GP  +      +  K   G  GV LPG  G  G PG+ G    PG  G
Sbjct: 2431 GREGIPGPLGPPGPPGSVGPPGASGLKGDKGDPGVGLPGPRGERGEPGIRGEDGRPGQEG 2490

Query: 285  IAGVGTPAAAAA--------AAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG-------- 328
              G+  P  +           +A  K  K  +A  L P GP    G +G  G        
Sbjct: 2491 PRGLTGPPGSRGERGEKGDVGSAGLKGDKGDSAVILGPPGPRGAKGDMGERGPRGLDGDK 2550

Query: 329  -----------------------AGVPGV-------GVPGA-GIPVVPGA----GIPGAA 353
                                   AG+PG+       G PGA GIP  PG+    G+PG  
Sbjct: 2551 GPRGDNGDPGDKGSKGEPGDKGSAGLPGLRGLLGPQGQPGAAGIPGDPGSPGKDGVPGIR 2610

Query: 354  VP----GVVSP-----EAAAKAAA-----KAAKYGA----RPGV-------GVGGIPTYG 388
                  G + P     E   K A      K  K  A    RPG+       G  G+P   
Sbjct: 2611 GEKGDVGFMGPRGLKGERGVKGACGLDGEKGDKGEAGPPGRPGLAGHKGEMGEPGVPGQS 2670

Query: 389  --------VGAGGFPGFG-----------VGVGGIPGVAGVPGVGGVPGVGGVPGV--GI 427
                    +G  G  GF             G  G PG+ G PG  G  G  G PG    +
Sbjct: 2671 GAPGKEGLIGPKGDRGFDGQPGPKGDQGEKGERGTPGIGGFPGPSGNDGSAGPPGPPGSV 2730

Query: 428  SPEAQAAAAAKAAKYGLVPGVGV--APGVGVAPG 459
             P        +  + G  PG  V  APGV  APG
Sbjct: 2731 GPRGPEGLQGQKGERG-PPGERVVGAPGVPGAPG 2763



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 153/535 (28%), Positives = 180/535 (33%), Gaps = 163/535 (30%)

Query: 23   PSRPG--GVPGAI-PGGVPGGVFYPALG----PGGKPLKPVPGGLAGAGLGAGLGAFPAV 75
            P  PG  G+PG + P G PG    P       PG K  K  PGGLAG  +G         
Sbjct: 2274 PGVPGSPGLPGPVGPKGEPGPTGAPGQAVVGLPGAKGEKGAPGGLAGDLVGE-------- 2325

Query: 76   TFPGAL----VPGGVADAAAAYKAAKAGA----GLGGVPGVGGLGVSAGAVVP-QPGAGV 126
              PGA     +PG   +   A +A + G     G  G PG  G     G  VP  PG   
Sbjct: 2326 --PGAKGDRGLPGPRGEKGEAGRAGEPGDPGEDGQKGAPGPKGFKGDPGVGVPGSPGPPG 2383

Query: 127  KPGKVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGG--AFAGIPG--- 181
             PG    +GLPG      LPGA  PGV   PG  TG   +   PG  G    AG PG   
Sbjct: 2384 PPGVKGDLGLPG------LPGA--PGVVGFPG-QTGPRGEMGQPGPSGERGLAGPPGREG 2434

Query: 182  -VGPFGGPQPGVPLGYP----IKAPKLPGGYGLPYTTGKL-----------PYGYGPGGV 225
              GP G P P   +G P    +K  K   G GLP   G+            P   GP G+
Sbjct: 2435 IPGPLGPPGPPGSVGPPGASGLKGDKGDPGVGLPGPRGERGEPGIRGEDGRPGQEGPRGL 2494

Query: 226  AGAAGKAGYPTGTG-----------------VGPQAAAAAAAKAAAKFGAGAAGVLPGVG 268
             G  G  G     G                 +GP     A      +   G  G     G
Sbjct: 2495 TGPPGSRGERGEKGDVGSAGLKGDKGDSAVILGPPGPRGAKGDMGERGPRGLDGDKGPRG 2554

Query: 269  GAGVPGVPGA-----------IPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLVPG- 315
              G PG  G+           +PG+ G+ G  G P AA          K G     VPG 
Sbjct: 2555 DNGDPGDKGSKGEPGDKGSAGLPGLRGLLGPQGQPGAAGIPGDPGSPGKDG-----VPGI 2609

Query: 316  ----------GPGFGPGVVGVPGA-GVPG-------VGVPGA----------GIPVVPG- 346
                      GP    G  GV GA G+ G        G PG           G P VPG 
Sbjct: 2610 RGEKGDVGFMGPRGLKGERGVKGACGLDGEKGDKGEAGPPGRPGLAGHKGEMGEPGVPGQ 2669

Query: 347  AGIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFG-------- 398
            +G PG    G++ P+       +    G +   G  G P    G GGFPG          
Sbjct: 2670 SGAPGKE--GLIGPKGDRGFDGQPGPKGDQGEKGERGTP----GIGGFPGPSGNDGSAGP 2723

Query: 399  -----------------------------VGVGGIPGVAGVPGVGGVPGVGGVPG 424
                                         VG  G+PG  G  G  G PG  G  G
Sbjct: 2724 PGPPGSVGPRGPEGLQGQKGERGPPGERVVGAPGVPGAPGERGEQGRPGPAGPRG 2778


>gi|89142737 alpha 3 type IV collagen isoform 5 precursor [Homo
            sapiens]
          Length = 1424

 Score =  139 bits (351), Expect = 7e-33
 Identities = 222/765 (29%), Positives = 268/765 (35%), Gaps = 156/765 (20%)

Query: 23   PSRPGGVPGAIPG----GVPGGVFYPAL----GPGGKPLKPVPG--GLAGAGLGAGLGAF 72
            PS P GVPG+ PG    G+ G   +P L    G  G+P K   G  G  G     GL   
Sbjct: 373  PSGPPGVPGS-PGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGS 431

Query: 73   PA-------VTF----------PGAL-------VPGGVADAAAAYKAAKAGAGLGGVPGV 108
            P        + F          PG L       V G   +            G  G+PG+
Sbjct: 432  PGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGL 491

Query: 109  GGLGVSAGAVVPQPGAGVK--PGKVPGVGLPGVYPGGVLPGARFPGVGVLPGV------- 159
             GL    G    Q  AG+K  PG     GLPG +PG       FPG    PG+       
Sbjct: 492  PGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPG-FPG-------FPGAQGDPGLKGEKGET 543

Query: 160  --PTGAGVKPKAPGVGG--------AFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGL 209
              P G    P  PG+ G           G PGV    GP+  + L         PG  G 
Sbjct: 544  LQPEGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGS 603

Query: 210  PYTTGKL----PYGYGPGGVAGAAGKAGYPTGTG----VGPQAAAAAAAKAAAKFG---- 257
            P + G      P GYGP G  G  G  G P   G     GP+   + +       G    
Sbjct: 604  PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGP 663

Query: 258  ------AGAAGVLPGVGGAGVPGVPG--AIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAA 309
                   G  G+   +G  G PG+PG    PGI GI   G P               G  
Sbjct: 664  PGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGFPGTKGSLGCP 723

Query: 310  AGLVPGGPGFGPGVVGVPGA-GVPGVGVPGA-GIPVVPG----------AGIPG-AAVPG 356
              +  G PG  PG  G+PGA G P V +PG  G P  PG           G+PG   +PG
Sbjct: 724  GKM--GEPGL-PGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLPG 780

Query: 357  VVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGV-GAGGFPGFG--------VGVGGIPGV 407
                E          + G     G  G    G  GA G PG           G  G  G 
Sbjct: 781  TPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGD 840

Query: 408  AGVPGV--GGVPGVGGVPGVGISPEAQAAAAAKAAK-YGLVPGVGVAPGVGVAPGVGVAP 464
             G+PG+   G PG  G PG+   P  Q        + Y   PG+   PG     G+   P
Sbjct: 841  PGIPGLDRSGFPGETGSPGI---PGHQGEMGPLGQRGYPGNPGILGPPGEDGVIGMMGFP 897

Query: 465  GVGLAPGVGVAPGVGVAPGVGVAPGI----GPGGVAAAAKSAAKVAAKAQLRAAAGLG-A 519
            G    PG    PG    PG   +PGI    G  G   A               +  +G  
Sbjct: 898  GAIGPPG---PPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDK 954

Query: 520  GIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGA 579
            G PGL    G PG     GVPG+    G+ G   +PG           A  PG  G LG+
Sbjct: 955  GEPGLKGFAGNPGEKGNRGVPGM---PGLKGLKGLPGP----------AGPPGPRGDLGS 1001

Query: 580  LGGVGIPG--GVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL-GVGGL---------- 626
             G  G PG  G+ G+        +K   K    G  G AG  GL G+ GL          
Sbjct: 1002 TGNPGEPGLRGIPGSMGNMGMPGSK--GKRGTLGFPGRAGRPGLPGIHGLQGDKGEPGYS 1059

Query: 627  -----GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGA 666
                 G PG  G  G+ P    K  + G    PG  L P  P GA
Sbjct: 1060 EGTRPGPPGPTGDPGL-PGDMGKKGEMGQPGPPGH-LGPAGPEGA 1102



 Score =  137 bits (346), Expect = 2e-32
 Identities = 208/704 (29%), Positives = 250/704 (35%), Gaps = 104/704 (14%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALV 82
            P+ P G PG  P G PG       G  G P  P P G AG   G    + P    PG   
Sbjct: 609  PAGPAGPPGYGPQGEPG-----LQGTQGVPGAPGPPGEAGP-RGELSVSTPVPGPPGPPG 662

Query: 83   PGGVADAAAAYKAAKAGAGLGGVPGV-GGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYP 141
            P G               G  G PG+ G LG      +P P    +PG +PG+G PG  P
Sbjct: 663  PPG-------------HPGPQGPPGIPGSLGKCGDPGLPGPDG--EPG-IPGIGFPG--P 704

Query: 142  GGVLPGARFPGVGVLPGVPTGAGVK--PKAPGVGGAFAGIPGVGPFGGPQPGVPLGYP-- 197
             G      FPG     G P   G    P  PG+ GA  G P V   GG  PG P G+P  
Sbjct: 705  PGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGA-KGEPAVAMPGG--PGTP-GFPGE 760

Query: 198  ---------IKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAA 248
                     I  P LPG  G P   G L    G  G  G  G+ G P     GP+ A   
Sbjct: 761  RGNSGEHGEIGLPGLPGLPGTPGNEG-LDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGL 819

Query: 249  AAKAAAKFGAGAAGVLPGVGGAGVPGVP-GAIPGIGGIAGVGTPAAAAAAAAAAKAAKYG 307
                  K   G  G     G  G+PG+     PG  G  G+  P          +    G
Sbjct: 820  PGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGSPGI--PGHQGEMGPLGQRGYPG 877

Query: 308  AAAGLVPGGPGFGPGVVGVPGAGVPGVGVPG-AGIPVVPG-AGIPGAAVPGVVSPEAAAK 365
                L P G     G++G PGA    +G PG  G P  PG  G PG  +PGV        
Sbjct: 878  NPGILGPPGEDGVIGMMGFPGA----IGPPGPPGNPGTPGQRGSPG--IPGVKGQRGTPG 931

Query: 366  AAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVG-----GIPGVAGVPGVGGVPGVG 420
            A  +    G  PG           G  G  GF    G     G+PG+ G+ G+ G+PG  
Sbjct: 932  AKGEQGDKG-NPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPA 990

Query: 421  GVPGVGISPEAQAAAAAKAAKYGL-----------VPGVGVAPGVGVAPGVGVAPGVGLA 469
            G PG    P     +     + GL           +PG     G    PG    PG+   
Sbjct: 991  GPPG----PRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGL--- 1043

Query: 470  PGVGVAPGVGVAPGV--GVAPG-IGPGGVAAAAKSAAKVAAKAQLRAAAGLG----AGIP 522
            PG+    G    PG   G  PG  GP G         K     Q      LG     G P
Sbjct: 1044 PGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAP 1103

Query: 523  GLGVGVGVPG-------LGVGA-----GVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAV 570
            G     G+PG       LG        G PG+    G+PGF   PG +   +  +    +
Sbjct: 1104 GSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPM-GIRGDQGRDGI 1162

Query: 571  PGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAA----AKAAQFGLVGAAGLGGLGVGGL 626
            PG  G  G  G +  P G  G   A  A   + A        + G +G AG  G   G  
Sbjct: 1163 PGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRG-PTGIE 1221

Query: 627  GVPGVGGL-GGIPPAAAAKAAKYGVAARPGFGLSPIFPGGACLG 669
            G PG  GL G I P         G    PG    P  PG   +G
Sbjct: 1222 GFPGPPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIG 1265



 Score =  133 bits (335), Expect = 5e-31
 Identities = 205/666 (30%), Positives = 246/666 (36%), Gaps = 112/666 (16%)

Query: 28  GVPGAI-PGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGG- 85
           G+PGA  P G+PG   +P  GP G P  P   G  G              FPGA+ P G 
Sbjct: 174 GLPGAPGPQGLPGPPGFP--GPVGPPGPP---GFFG--------------FPGAMGPRGP 214

Query: 86  ---VADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVK--PGKVPGVGLPGVY 140
              + +    +K  +   GL G PG  G  V      P     +K   G    +G PG  
Sbjct: 215 KGHMGERVIGHKGERGVKGLTGPPGPPGT-VIVTLTGPDNRTDLKGEKGDKGAMGEPGPP 273

Query: 141 PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKA 200
               LPG  +      PG P G   KP   GV G F G  GV    G  PG+     IK 
Sbjct: 274 GPSGLPGESYGSEKGAPGDP-GLQGKPGKDGVPG-FPGSEGVKGNRG-FPGLMGEDGIKG 330

Query: 201 PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGAG 259
            K  G  G P   G   Y Y      G  G  G P   G  GPQ  +            G
Sbjct: 331 QK--GDIGPPGFRGPTEY-YDTYQEKGDEGTPGPPGPRGARGPQGPS------------G 375

Query: 260 AAGVLPGVGGAGVPGVPGAI--PGIGGIAG---------VGTPAAAAAAAAAAKAAKYGA 308
             GV PG  G+  PG+ GA   PG+ G  G         +GTP +   A +       G 
Sbjct: 376 PPGV-PGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGP 434

Query: 309 AAGLVPGGPGF------GPGVVGVPG----AGVPGV----GVPG---AGIPVVPGA-GIP 350
                PG PG        PG  G+PG     G+PGV    G PG      P +PG  G+P
Sbjct: 435 -----PGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLP 489

Query: 351 GA-AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFG----------- 398
           G   + GV        AA      G+    G+ G P +  GA G PG             
Sbjct: 490 GLPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFP-GAQGDPGLKGEKGETLQPEG 548

Query: 399 -VGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVA 457
            VGV G PG+ G PG  G+ G+ G PGV   P  +   A    K    P     PG   +
Sbjct: 549 QVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGP-----PGDPGS 603

Query: 458 PGVGVAPGVGLAPGVGV--APGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAA 515
           PG     G    PG G    PG+    GV  APG  PG   A  +    V+         
Sbjct: 604 PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPG-PPG--EAGPRGELSVSTPVPGPPGP 660

Query: 516 GLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPG-ALAAAKAAKYGAAVPGVL 574
               G PG     G+PG     G PGL    G PG   +PG         K     PG  
Sbjct: 661 PGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPG---IPGIGFPGPPGPKGDQGFPGTK 717

Query: 575 GGLGALGGVGIPG--GVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVG 632
           G LG  G +G PG  G  G   A    A          G  G  G  G   G +G+PG+ 
Sbjct: 718 GSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSG-EHGEIGLPGLP 776

Query: 633 GLGGIP 638
           GL G P
Sbjct: 777 GLPGTP 782



 Score =  131 bits (330), Expect = 2e-30
 Identities = 218/776 (28%), Positives = 272/776 (35%), Gaps = 168/776 (21%)

Query: 7    AAPRPGVLLLLLSILHPSRPGGVPGAI----PGGVPGGVFYPALGPGGKPLKPVPGGLAG 62
            A PR G L +   +  P  P G PG      P G+PG     +LG  G P  P P G  G
Sbjct: 642  AGPR-GELSVSTPVPGPPGPPGPPGHPGPQGPPGIPG-----SLGKCGDPGLPGPDGEPG 695

Query: 63   AGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA----GLGGVPGVGGL-GVSAGA 117
                      P + FPG   PG   D          G     G  G+PG  GL G     
Sbjct: 696  ---------IPGIGFPGP--PGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGEP 744

Query: 118  VVPQPGAGVKPGKVPG----------VGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKP 167
             V  PG    PG  PG          +GLPG+ PG  LPG   PG   L G P G   +P
Sbjct: 745  AVAMPGGPGTPG-FPGERGNSGEHGEIGLPGL-PG--LPGT--PGNEGLDG-PRGDPGQP 797

Query: 168  KAPGVGG----------AFAGIPGVGPFGGPQ-----------PGVP----LGYPIK--A 200
              PG  G             G+PG+    G Q           PG+P     G+P +  +
Sbjct: 798  GPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGS 857

Query: 201  PKLPGGYGLPYTTGKLPYGYGPG--------------GVAGAAGKAGYPTGTGV------ 240
            P +PG  G     G+  Y   PG              G  GA G  G P   G       
Sbjct: 858  PGIPGHQGEMGPLGQRGYPGNPGILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGS 917

Query: 241  -------GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAI--PGIGGIAGV-GT 290
                   G +    A  +   K   G + +   +G  G PG+ G    PG  G  GV G 
Sbjct: 918  PGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGM 977

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA----GVPG-------VGVPG- 338
            P           A   G    L   G    PG+ G+PG+    G+PG       +G PG 
Sbjct: 978  PGLKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGR 1037

Query: 339  AGIPVVPGA-------GIPGAAV---PGVVSPEAAAKAAAKAAKYG--ARPG----VGVG 382
            AG P +PG        G PG +    PG   P           K G   +PG    +G  
Sbjct: 1038 AGRPGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPA 1097

Query: 383  GIPTYGVGAGGFPGF--------GVGVGGIPGVAGVPGVGGVPGVGGVPG----VGI-SP 429
            G P    G+ G PG          +G  GI G+ G PG+ G PG+ G PG    +GI   
Sbjct: 1098 G-PEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGD 1156

Query: 430  EAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG 489
            + +      A + G    +   PG    PG   A G   APG    PG   A  +G A  
Sbjct: 1157 QGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGA--MGDAGP 1214

Query: 490  IGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVP 549
             GP G+                        G PGL  G  +PG     G PG     G P
Sbjct: 1215 RGPTGIEGF--------------------PGPPGL-PGAIIPGQTGNRGPPGSRGSPGAP 1253

Query: 550  GFGAVPGA-LAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAA 608
            G    PG+ +   K  K     PG  G  G  G +G PG +   G               
Sbjct: 1254 GPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQG 1313

Query: 609  QFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
              G+ G  G  G  +G +G PG  G  G PP          + + PG    P  PG
Sbjct: 1314 FPGVKGEKGNPGF-LGSIGPPGPIGPKG-PPGVRGDPGTLKIISLPGSPGPPGTPG 1367



 Score =  108 bits (269), Expect = 2e-23
 Identities = 181/619 (29%), Positives = 216/619 (34%), Gaps = 130/619 (21%)

Query: 22   HPSRPG--GVPGAIPGGVPGGVFYP-ALGPGGKPLKP----------VPGGLAGAGLGAG 68
            +P  PG  G PG    GV G + +P A+GP G P  P          +PG     G    
Sbjct: 875  YPGNPGILGPPGE--DGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGA 932

Query: 69   LGAFPAVTFPG----ALVPGGVADAA----AAYKAAKAGAGLGGVPGVGGL-GVSAGAVV 119
             G       PG    + V G   +      A     K   G+ G+PG+ GL G+   A  
Sbjct: 933  KGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGP 992

Query: 120  PQP----GAGVKPGKVPGV-GLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGG 174
            P P    G+   PG+ PG+ G+PG      +PG++  G     G P  AG +P  PG+ G
Sbjct: 993  PGPRGDLGSTGNPGE-PGLRGIPGSMGNMGMPGSK--GKRGTLGFPGRAG-RPGLPGIHG 1048

Query: 175  AFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKL--PYGYGPGGVAGAAGKA 232
                    G   G +PG P   P   P LPG  G     G+   P   GP G  GA G  
Sbjct: 1049 LQGDKGEPGYSEGTRPGPP--GPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAPGSP 1106

Query: 233  GYPTGTGV-GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGV-GT 290
            G P   G  GP                G  G+L   G  G PG+PG  PG  G  G+ G 
Sbjct: 1107 GSPGLPGKPGPHGDLGFK---------GIKGLLGPPGIRGPPGLPG-FPGSPGPMGIRGD 1156

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG-AGVPGV-GVPG---------- 338
                     A +  + G      P GP   PG  G  G  G PG  G+PG          
Sbjct: 1157 QGRDGIPGPAGEKGETGLLRA--PPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGP 1214

Query: 339  ---AGIPVVPGA-GIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGF 394
                GI   PG  G+PGA +PG                 G+R   G  G P       G 
Sbjct: 1215 RGPTGIEGFPGPPGLPGAIIPGQTGNRGPP---------GSRGSPGAPGPP-------GP 1258

Query: 395  PGFGV-GVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPG 453
            PG  V G+ G  G  G PG  G PG  G  G                     PG   APG
Sbjct: 1259 PGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGP--------------------PGRLGAPG 1298

Query: 454  VGVAPGVGVAPGVGLAPGV-GVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLR 512
                PG    PG    PGV G     G    +G    IGP G                  
Sbjct: 1299 TPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVR------------- 1345

Query: 513  AAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALA----AAKAAKYG- 567
                   G PG    + +PG     G PG     G PG    PG L       K  K G 
Sbjct: 1346 -------GDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGK 1398

Query: 568  AAVPGVLGGLGALGGVGIP 586
               PG  G  G  G  G P
Sbjct: 1399 PGTPGPAGEKGNKGSKGEP 1417



 Score =  107 bits (268), Expect = 3e-23
 Identities = 177/598 (29%), Positives = 218/598 (36%), Gaps = 105/598 (17%)

Query: 135 GLPGVYPGGVLPGAR-FPGVGVLPGVPTGAGVKPKAPGVGGA--FAGIPGVGPFGGPQPG 191
           G PG  PG   PG + F G   LPG P G    P  PG+ G+    GI G+  F G  PG
Sbjct: 52  GFPGP-PGS--PGQKGFTGPEGLPG-PQGPKGFPGLPGLTGSKGVRGISGLPGFSG-SPG 106

Query: 192 VPLGYPIKAPKLPGGYGLPYTTG----KLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAA 247
           +P       P   G YGL    G    K   G+   G+ G  G  G P   G+  Q  A 
Sbjct: 107 LP-----GTPGNTGPYGLVGVPGCSGSKGEQGFP--GLPGTLGYPGIPGAAGLKGQKGAP 159

Query: 248 AAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYG 307
           A  +       G  G+    G  G+PG PG  PG      VG P              +G
Sbjct: 160 AKEEDIELDAKGDPGLPGAPGPQGLPGPPG-FPG-----PVGPPGPPGF---------FG 204

Query: 308 AAAGLVPGGP--GFGPGVVGVPG-AGVPGVGVPGAGIPVVPGAGIPGAAVPGVVSPEAAA 364
               + P GP    G  V+G  G  GV G+  P          G PG  +  +  P+   
Sbjct: 205 FPGAMGPRGPKGHMGERVIGHKGERGVKGLTGP---------PGPPGTVIVTLTGPDNRT 255

Query: 365 KAAAKAAKYGA--RPG-VGVGGIP--TYG--VGAGGFPGF-----GVGVGGIPGVAGVPG 412
               +    GA   PG  G  G+P  +YG   GA G PG        GV G PG  GV G
Sbjct: 256 DLKGEKGDKGAMGEPGPPGPSGLPGESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGVKG 315

Query: 413 VGGVPGVGGVPGV-----GISPEAQAAAAAKAAKYGL-----VPGVGVAPGVGVAPGVGV 462
             G PG+ G  G+      I P            Y        PG     G     G   
Sbjct: 316 NRGFPGLMGEDGIKGQKGDIGPPGFRGPTEYYDTYQEKGDEGTPGPPGPRGARGPQGPSG 375

Query: 463 APGVGLAPGVGVAPGVGVAPG-VGVAPGIG----PGGVAAAAKSAAKVAAKAQLRAAAGL 517
            PGV  +PG    PG+  APG  G+    G    PG  A     +   A    L  + G 
Sbjct: 376 PPGVPGSPG-SSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGP 434

Query: 518 GA---------------GIPGLGVGVGVPGLGVGAGVPGL-----GVGAGVPGFGAVPGA 557
                            G+PG     G+PG+    G PGL         G PG   +PG 
Sbjct: 435 PGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGLPG- 493

Query: 558 LAAAKAAKYGAAVPGVLGGLGALGGVGIPG--GVVGA--GPAAAAAAAKAAAKAAQFGLV 613
           L   K         G+ G  G+ G  G+PG  G  GA   P       +      Q G+ 
Sbjct: 494 LHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQPEGQVGVP 553

Query: 614 GAAGL----GGLGVGGL-GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGA 666
           G  GL    G  G+ G+ G PGV GL G P    A + + G    PG   SP  PG A
Sbjct: 554 GDPGLRGQPGRKGLDGIPGTPGVKGLPG-PKGELALSGEKGDQGPPGDPGSPGSPGPA 610


>gi|89142735 alpha 3 type IV collagen isoform 4 precursor [Homo
            sapiens]
          Length = 1494

 Score =  139 bits (351), Expect = 7e-33
 Identities = 222/765 (29%), Positives = 268/765 (35%), Gaps = 156/765 (20%)

Query: 23   PSRPGGVPGAIPG----GVPGGVFYPAL----GPGGKPLKPVPG--GLAGAGLGAGLGAF 72
            PS P GVPG+ PG    G+ G   +P L    G  G+P K   G  G  G     GL   
Sbjct: 373  PSGPPGVPGS-PGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGS 431

Query: 73   PA-------VTF----------PGAL-------VPGGVADAAAAYKAAKAGAGLGGVPGV 108
            P        + F          PG L       V G   +            G  G+PG+
Sbjct: 432  PGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGL 491

Query: 109  GGLGVSAGAVVPQPGAGVK--PGKVPGVGLPGVYPGGVLPGARFPGVGVLPGV------- 159
             GL    G    Q  AG+K  PG     GLPG +PG       FPG    PG+       
Sbjct: 492  PGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPG-FPG-------FPGAQGDPGLKGEKGET 543

Query: 160  --PTGAGVKPKAPGVGG--------AFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGL 209
              P G    P  PG+ G           G PGV    GP+  + L         PG  G 
Sbjct: 544  LQPEGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGS 603

Query: 210  PYTTGKL----PYGYGPGGVAGAAGKAGYPTGTG----VGPQAAAAAAAKAAAKFG---- 257
            P + G      P GYGP G  G  G  G P   G     GP+   + +       G    
Sbjct: 604  PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGP 663

Query: 258  ------AGAAGVLPGVGGAGVPGVPG--AIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAA 309
                   G  G+   +G  G PG+PG    PGI GI   G P               G  
Sbjct: 664  PGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGFPGTKGSLGCP 723

Query: 310  AGLVPGGPGFGPGVVGVPGA-GVPGVGVPGA-GIPVVPG----------AGIPG-AAVPG 356
              +  G PG  PG  G+PGA G P V +PG  G P  PG           G+PG   +PG
Sbjct: 724  GKM--GEPGL-PGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLPG 780

Query: 357  VVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGV-GAGGFPGFG--------VGVGGIPGV 407
                E          + G     G  G    G  GA G PG           G  G  G 
Sbjct: 781  TPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGD 840

Query: 408  AGVPGV--GGVPGVGGVPGVGISPEAQAAAAAKAAK-YGLVPGVGVAPGVGVAPGVGVAP 464
             G+PG+   G PG  G PG+   P  Q        + Y   PG+   PG     G+   P
Sbjct: 841  PGIPGLDRSGFPGETGSPGI---PGHQGEMGPLGQRGYPGNPGILGPPGEDGVIGMMGFP 897

Query: 465  GVGLAPGVGVAPGVGVAPGVGVAPGI----GPGGVAAAAKSAAKVAAKAQLRAAAGLG-A 519
            G    PG    PG    PG   +PGI    G  G   A               +  +G  
Sbjct: 898  GAIGPPG---PPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDK 954

Query: 520  GIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGA 579
            G PGL    G PG     GVPG+    G+ G   +PG           A  PG  G LG+
Sbjct: 955  GEPGLKGFAGNPGEKGNRGVPGM---PGLKGLKGLPGP----------AGPPGPRGDLGS 1001

Query: 580  LGGVGIPG--GVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL-GVGGL---------- 626
             G  G PG  G+ G+        +K   K    G  G AG  GL G+ GL          
Sbjct: 1002 TGNPGEPGLRGIPGSMGNMGMPGSK--GKRGTLGFPGRAGRPGLPGIHGLQGDKGEPGYS 1059

Query: 627  -----GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGA 666
                 G PG  G  G+ P    K  + G    PG  L P  P GA
Sbjct: 1060 EGTRPGPPGPTGDPGL-PGDMGKKGEMGQPGPPGH-LGPAGPEGA 1102



 Score =  137 bits (346), Expect = 2e-32
 Identities = 208/704 (29%), Positives = 250/704 (35%), Gaps = 104/704 (14%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALV 82
            P+ P G PG  P G PG       G  G P  P P G AG   G    + P    PG   
Sbjct: 609  PAGPAGPPGYGPQGEPG-----LQGTQGVPGAPGPPGEAGP-RGELSVSTPVPGPPGPPG 662

Query: 83   PGGVADAAAAYKAAKAGAGLGGVPGV-GGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYP 141
            P G               G  G PG+ G LG      +P P    +PG +PG+G PG  P
Sbjct: 663  PPG-------------HPGPQGPPGIPGSLGKCGDPGLPGPDG--EPG-IPGIGFPG--P 704

Query: 142  GGVLPGARFPGVGVLPGVPTGAGVK--PKAPGVGGAFAGIPGVGPFGGPQPGVPLGYP-- 197
             G      FPG     G P   G    P  PG+ GA  G P V   GG  PG P G+P  
Sbjct: 705  PGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGA-KGEPAVAMPGG--PGTP-GFPGE 760

Query: 198  ---------IKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAA 248
                     I  P LPG  G P   G L    G  G  G  G+ G P     GP+ A   
Sbjct: 761  RGNSGEHGEIGLPGLPGLPGTPGNEG-LDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGL 819

Query: 249  AAKAAAKFGAGAAGVLPGVGGAGVPGVP-GAIPGIGGIAGVGTPAAAAAAAAAAKAAKYG 307
                  K   G  G     G  G+PG+     PG  G  G+  P          +    G
Sbjct: 820  PGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGSPGI--PGHQGEMGPLGQRGYPG 877

Query: 308  AAAGLVPGGPGFGPGVVGVPGAGVPGVGVPG-AGIPVVPG-AGIPGAAVPGVVSPEAAAK 365
                L P G     G++G PGA    +G PG  G P  PG  G PG  +PGV        
Sbjct: 878  NPGILGPPGEDGVIGMMGFPGA----IGPPGPPGNPGTPGQRGSPG--IPGVKGQRGTPG 931

Query: 366  AAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVG-----GIPGVAGVPGVGGVPGVG 420
            A  +    G  PG           G  G  GF    G     G+PG+ G+ G+ G+PG  
Sbjct: 932  AKGEQGDKG-NPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPA 990

Query: 421  GVPGVGISPEAQAAAAAKAAKYGL-----------VPGVGVAPGVGVAPGVGVAPGVGLA 469
            G PG    P     +     + GL           +PG     G    PG    PG+   
Sbjct: 991  GPPG----PRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGL--- 1043

Query: 470  PGVGVAPGVGVAPGV--GVAPG-IGPGGVAAAAKSAAKVAAKAQLRAAAGLG----AGIP 522
            PG+    G    PG   G  PG  GP G         K     Q      LG     G P
Sbjct: 1044 PGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAP 1103

Query: 523  GLGVGVGVPG-------LGVGA-----GVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAV 570
            G     G+PG       LG        G PG+    G+PGF   PG +   +  +    +
Sbjct: 1104 GSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPM-GIRGDQGRDGI 1162

Query: 571  PGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAA----AKAAQFGLVGAAGLGGLGVGGL 626
            PG  G  G  G +  P G  G   A  A   + A        + G +G AG  G   G  
Sbjct: 1163 PGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRG-PTGIE 1221

Query: 627  GVPGVGGL-GGIPPAAAAKAAKYGVAARPGFGLSPIFPGGACLG 669
            G PG  GL G I P         G    PG    P  PG   +G
Sbjct: 1222 GFPGPPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIG 1265



 Score =  133 bits (335), Expect = 5e-31
 Identities = 205/666 (30%), Positives = 246/666 (36%), Gaps = 112/666 (16%)

Query: 28  GVPGAI-PGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGG- 85
           G+PGA  P G+PG   +P  GP G P  P   G  G              FPGA+ P G 
Sbjct: 174 GLPGAPGPQGLPGPPGFP--GPVGPPGPP---GFFG--------------FPGAMGPRGP 214

Query: 86  ---VADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVK--PGKVPGVGLPGVY 140
              + +    +K  +   GL G PG  G  V      P     +K   G    +G PG  
Sbjct: 215 KGHMGERVIGHKGERGVKGLTGPPGPPGT-VIVTLTGPDNRTDLKGEKGDKGAMGEPGPP 273

Query: 141 PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKA 200
               LPG  +      PG P G   KP   GV G F G  GV    G  PG+     IK 
Sbjct: 274 GPSGLPGESYGSEKGAPGDP-GLQGKPGKDGVPG-FPGSEGVKGNRG-FPGLMGEDGIKG 330

Query: 201 PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGAG 259
            K  G  G P   G   Y Y      G  G  G P   G  GPQ  +            G
Sbjct: 331 QK--GDIGPPGFRGPTEY-YDTYQEKGDEGTPGPPGPRGARGPQGPS------------G 375

Query: 260 AAGVLPGVGGAGVPGVPGAI--PGIGGIAG---------VGTPAAAAAAAAAAKAAKYGA 308
             GV PG  G+  PG+ GA   PG+ G  G         +GTP +   A +       G 
Sbjct: 376 PPGV-PGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGP 434

Query: 309 AAGLVPGGPGF------GPGVVGVPG----AGVPGV----GVPG---AGIPVVPGA-GIP 350
                PG PG        PG  G+PG     G+PGV    G PG      P +PG  G+P
Sbjct: 435 -----PGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLP 489

Query: 351 GA-AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFG----------- 398
           G   + GV        AA      G+    G+ G P +  GA G PG             
Sbjct: 490 GLPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFP-GAQGDPGLKGEKGETLQPEG 548

Query: 399 -VGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVA 457
            VGV G PG+ G PG  G+ G+ G PGV   P  +   A    K    P     PG   +
Sbjct: 549 QVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGP-----PGDPGS 603

Query: 458 PGVGVAPGVGLAPGVGV--APGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAA 515
           PG     G    PG G    PG+    GV  APG  PG   A  +    V+         
Sbjct: 604 PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPG-PPG--EAGPRGELSVSTPVPGPPGP 660

Query: 516 GLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPG-ALAAAKAAKYGAAVPGVL 574
               G PG     G+PG     G PGL    G PG   +PG         K     PG  
Sbjct: 661 PGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPG---IPGIGFPGPPGPKGDQGFPGTK 717

Query: 575 GGLGALGGVGIPG--GVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVG 632
           G LG  G +G PG  G  G   A    A          G  G  G  G   G +G+PG+ 
Sbjct: 718 GSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSG-EHGEIGLPGLP 776

Query: 633 GLGGIP 638
           GL G P
Sbjct: 777 GLPGTP 782



 Score =  131 bits (330), Expect = 2e-30
 Identities = 218/776 (28%), Positives = 272/776 (35%), Gaps = 168/776 (21%)

Query: 7    AAPRPGVLLLLLSILHPSRPGGVPGAI----PGGVPGGVFYPALGPGGKPLKPVPGGLAG 62
            A PR G L +   +  P  P G PG      P G+PG     +LG  G P  P P G  G
Sbjct: 642  AGPR-GELSVSTPVPGPPGPPGPPGHPGPQGPPGIPG-----SLGKCGDPGLPGPDGEPG 695

Query: 63   AGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA----GLGGVPGVGGL-GVSAGA 117
                      P + FPG   PG   D          G     G  G+PG  GL G     
Sbjct: 696  ---------IPGIGFPGP--PGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGEP 744

Query: 118  VVPQPGAGVKPGKVPG----------VGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKP 167
             V  PG    PG  PG          +GLPG+ PG  LPG   PG   L G P G   +P
Sbjct: 745  AVAMPGGPGTPG-FPGERGNSGEHGEIGLPGL-PG--LPGT--PGNEGLDG-PRGDPGQP 797

Query: 168  KAPGVGG----------AFAGIPGVGPFGGPQ-----------PGVP----LGYPIK--A 200
              PG  G             G+PG+    G Q           PG+P     G+P +  +
Sbjct: 798  GPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGS 857

Query: 201  PKLPGGYGLPYTTGKLPYGYGPG--------------GVAGAAGKAGYPTGTGV------ 240
            P +PG  G     G+  Y   PG              G  GA G  G P   G       
Sbjct: 858  PGIPGHQGEMGPLGQRGYPGNPGILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGS 917

Query: 241  -------GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAI--PGIGGIAGV-GT 290
                   G +    A  +   K   G + +   +G  G PG+ G    PG  G  GV G 
Sbjct: 918  PGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGM 977

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA----GVPG-------VGVPG- 338
            P           A   G    L   G    PG+ G+PG+    G+PG       +G PG 
Sbjct: 978  PGLKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGR 1037

Query: 339  AGIPVVPGA-------GIPGAAV---PGVVSPEAAAKAAAKAAKYG--ARPG----VGVG 382
            AG P +PG        G PG +    PG   P           K G   +PG    +G  
Sbjct: 1038 AGRPGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPA 1097

Query: 383  GIPTYGVGAGGFPGF--------GVGVGGIPGVAGVPGVGGVPGVGGVPG----VGI-SP 429
            G P    G+ G PG          +G  GI G+ G PG+ G PG+ G PG    +GI   
Sbjct: 1098 G-PEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGD 1156

Query: 430  EAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG 489
            + +      A + G    +   PG    PG   A G   APG    PG   A  +G A  
Sbjct: 1157 QGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGA--MGDAGP 1214

Query: 490  IGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVP 549
             GP G+                        G PGL  G  +PG     G PG     G P
Sbjct: 1215 RGPTGIEGF--------------------PGPPGL-PGAIIPGQTGNRGPPGSRGSPGAP 1253

Query: 550  GFGAVPGA-LAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAA 608
            G    PG+ +   K  K     PG  G  G  G +G PG +   G               
Sbjct: 1254 GPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQG 1313

Query: 609  QFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
              G+ G  G  G  +G +G PG  G  G PP          + + PG    P  PG
Sbjct: 1314 FPGVKGEKGNPGF-LGSIGPPGPIGPKG-PPGVRGDPGTLKIISLPGSPGPPGTPG 1367



 Score =  110 bits (276), Expect = 3e-24
 Identities = 191/666 (28%), Positives = 228/666 (34%), Gaps = 163/666 (24%)

Query: 22   HPSRPG--GVPGAIPGGVPGGVFYP-ALGPGGKPLKP----------VPGGLAGAGLGAG 68
            +P  PG  G PG    GV G + +P A+GP G P  P          +PG     G    
Sbjct: 875  YPGNPGILGPPGE--DGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGA 932

Query: 69   LGAFPAVTFPG----ALVPGGVADAA----AAYKAAKAGAGLGGVPGVGGL-GVSAGAVV 119
             G       PG    + V G   +      A     K   G+ G+PG+ GL G+   A  
Sbjct: 933  KGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGP 992

Query: 120  PQP----GAGVKPGKVPGV-GLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGG 174
            P P    G+   PG+ PG+ G+PG      +PG++  G     G P  AG +P  PG+ G
Sbjct: 993  PGPRGDLGSTGNPGE-PGLRGIPGSMGNMGMPGSK--GKRGTLGFPGRAG-RPGLPGIHG 1048

Query: 175  AFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKL--PYGYGPGGVAGAAGKA 232
                    G   G +PG P   P   P LPG  G     G+   P   GP G  GA G  
Sbjct: 1049 LQGDKGEPGYSEGTRPGPP--GPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAPGSP 1106

Query: 233  GYPTGTGV-GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGV-GT 290
            G P   G  GP                G  G+L   G  G PG+PG  PG  G  G+ G 
Sbjct: 1107 GSPGLPGKPGPHGDLGFK---------GIKGLLGPPGIRGPPGLPG-FPGSPGPMGIRGD 1156

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG-AGVPGV-GVPG---------- 338
                     A +  + G      P GP   PG  G  G  G PG  G+PG          
Sbjct: 1157 QGRDGIPGPAGEKGETGLLRA--PPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGP 1214

Query: 339  ---AGIPVVPGA-GIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGF 394
                GI   PG  G+PGA +PG                 G+R   G  G P       G 
Sbjct: 1215 RGPTGIEGFPGPPGLPGAIIPGQTGNRGPP---------GSRGSPGAPGPP-------GP 1258

Query: 395  PGFGV-GVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPG 453
            PG  V G+ G  G  G PG  G PG  G  G                     PG   APG
Sbjct: 1259 PGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGP--------------------PGRLGAPG 1298

Query: 454  VGVAPGVGVAPGVGLAPGV-GVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLR 512
                PG    PG    PGV G     G    +G    IGP G                  
Sbjct: 1299 TPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVR------------- 1345

Query: 513  AAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPG 572
                   G PG    + +PG     G PG       PG    PG              PG
Sbjct: 1346 -------GDPGTLKIISLPGSPGPPGTPG------EPGMQGEPGP-------------PG 1379

Query: 573  VLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVG 632
              G LG  G  G PG                  K  + G  G AG  G   G  G PG  
Sbjct: 1380 PPGNLGPCGPRGKPG------------------KDGKPGTPGPAGEKG-NKGSKGEPGPA 1420

Query: 633  GLGGIP 638
            G  G+P
Sbjct: 1421 GSDGLP 1426



 Score =  107 bits (268), Expect = 3e-23
 Identities = 177/598 (29%), Positives = 218/598 (36%), Gaps = 105/598 (17%)

Query: 135 GLPGVYPGGVLPGAR-FPGVGVLPGVPTGAGVKPKAPGVGGA--FAGIPGVGPFGGPQPG 191
           G PG  PG   PG + F G   LPG P G    P  PG+ G+    GI G+  F G  PG
Sbjct: 52  GFPGP-PGS--PGQKGFTGPEGLPG-PQGPKGFPGLPGLTGSKGVRGISGLPGFSG-SPG 106

Query: 192 VPLGYPIKAPKLPGGYGLPYTTG----KLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAA 247
           +P       P   G YGL    G    K   G+   G+ G  G  G P   G+  Q  A 
Sbjct: 107 LP-----GTPGNTGPYGLVGVPGCSGSKGEQGFP--GLPGTLGYPGIPGAAGLKGQKGAP 159

Query: 248 AAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYG 307
           A  +       G  G+    G  G+PG PG  PG      VG P              +G
Sbjct: 160 AKEEDIELDAKGDPGLPGAPGPQGLPGPPG-FPG-----PVGPPGPPGF---------FG 204

Query: 308 AAAGLVPGGP--GFGPGVVGVPG-AGVPGVGVPGAGIPVVPGAGIPGAAVPGVVSPEAAA 364
               + P GP    G  V+G  G  GV G+  P          G PG  +  +  P+   
Sbjct: 205 FPGAMGPRGPKGHMGERVIGHKGERGVKGLTGP---------PGPPGTVIVTLTGPDNRT 255

Query: 365 KAAAKAAKYGA--RPG-VGVGGIP--TYG--VGAGGFPGF-----GVGVGGIPGVAGVPG 412
               +    GA   PG  G  G+P  +YG   GA G PG        GV G PG  GV G
Sbjct: 256 DLKGEKGDKGAMGEPGPPGPSGLPGESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGVKG 315

Query: 413 VGGVPGVGGVPGV-----GISPEAQAAAAAKAAKYGL-----VPGVGVAPGVGVAPGVGV 462
             G PG+ G  G+      I P            Y        PG     G     G   
Sbjct: 316 NRGFPGLMGEDGIKGQKGDIGPPGFRGPTEYYDTYQEKGDEGTPGPPGPRGARGPQGPSG 375

Query: 463 APGVGLAPGVGVAPGVGVAPG-VGVAPGIG----PGGVAAAAKSAAKVAAKAQLRAAAGL 517
            PGV  +PG    PG+  APG  G+    G    PG  A     +   A    L  + G 
Sbjct: 376 PPGVPGSPG-SSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGP 434

Query: 518 GA---------------GIPGLGVGVGVPGLGVGAGVPGL-----GVGAGVPGFGAVPGA 557
                            G+PG     G+PG+    G PGL         G PG   +PG 
Sbjct: 435 PGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGLPG- 493

Query: 558 LAAAKAAKYGAAVPGVLGGLGALGGVGIPG--GVVGA--GPAAAAAAAKAAAKAAQFGLV 613
           L   K         G+ G  G+ G  G+PG  G  GA   P       +      Q G+ 
Sbjct: 494 LHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQPEGQVGVP 553

Query: 614 GAAGL----GGLGVGGL-GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGA 666
           G  GL    G  G+ G+ G PGV GL G P    A + + G    PG   SP  PG A
Sbjct: 554 GDPGLRGQPGRKGLDGIPGTPGVKGLPG-PKGELALSGEKGDQGPPGDPGSPGSPGPA 610



 Score =  102 bits (253), Expect = 2e-21
 Identities = 147/512 (28%), Positives = 183/512 (35%), Gaps = 86/512 (16%)

Query: 23   PSRPG-----GVPGAIPGGVPG--GVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAV 75
            P  PG     G+PG  P G PG  G       PG   L+ +PG +   G+    G    +
Sbjct: 975  PGMPGLKGLKGLPG--PAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTL 1032

Query: 76   TFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVG 135
             FPG                    AG  G+PG+ GL    G   P    G +PG     G
Sbjct: 1033 GFPGR-------------------AGRPGLPGIHGLQGDKGE--PGYSEGTRPGPPGPTG 1071

Query: 136  LPGVYPGGVLP----GARFPGVGVLPGVPTGAGVKPKAPGVGG--------AFAGIPGV- 182
             PG+ PG +      G   P   + P  P GA   P +PG+ G         F GI G+ 
Sbjct: 1072 DPGL-PGDMGKKGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLL 1130

Query: 183  GPFG--GPQPGVPLGYPIKAPKLPGGYGLPYTTGK--LPYGYGPGGVAGAAGKAGYPTGT 238
            GP G  GP PG+P G+P      PG  G+    G+  +P   GP G  G  G    P G 
Sbjct: 1131 GPPGIRGP-PGLP-GFPGS----PGPMGIRGDQGRDGIP---GPAGEKGETGLLRAPPGP 1181

Query: 239  GVGPQAAAAAAAKAAAKFGA--GAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAA 296
               P A  A   + A  F    G  G +   G  G  G+ G  PG  G+ G   P     
Sbjct: 1182 RGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEG-FPGPPGLPGAIIPGQTGN 1240

Query: 297  AAAAAKAAKYGAAAGLVPGGPGF-GPGVVGVPG----AGVPGV-GVPGAGIPVVPGAGIP 350
                      GA     PG PG  G  V+G+ G     G PG  G PG    + P   + 
Sbjct: 1241 RGPPGSRGSPGA-----PGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLG 1295

Query: 351  GAAVPGVVSPEAAAKAAAKAAKYGARPGVG-VGGI-PTYGVGAGGFPGFGVGVG------ 402
                PG+  P             G +   G +G I P   +G  G PG     G      
Sbjct: 1296 APGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRGDPGTLKIIS 1355

Query: 403  -----GIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVA 457
                 G PG  G PG+ G PG  G PG  + P        K  K G     G     G  
Sbjct: 1356 LPGSPGPPGTPGEPGMQGEPGPPGPPG-NLGPCGPRGKPGKDGKPGTPGPAGEKGNKGSK 1414

Query: 458  PGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG 489
               G A   GL PG+    G   +P      G
Sbjct: 1415 GEPGPAGSDGL-PGLKGKRGDSGSPATWTTRG 1445



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 150/505 (29%), Positives = 189/505 (37%), Gaps = 80/505 (15%)

Query: 1    MAGLTAAAPRPGVLLLLLSILHPSRPG--GVPGAIPG-GVPGGVFYPA-LGPGGKPLKPV 56
            + GL   A  PG    L S  +P  PG  G+PG++   G+PG       LG  G+  +P 
Sbjct: 983  LKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPG 1042

Query: 57   PGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA-GLGGVPG-VGGLGVS 114
              G+ G     G   +   T PG   PG   D        K G  G  G PG +G  G  
Sbjct: 1043 LPGIHGLQGDKGEPGYSEGTRPGP--PGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPE 1100

Query: 115  AGAVVP-QPGAGVKPGKVPGVGLPGVY----PGGV-----LPGARFPG----VGVL---- 156
                 P  PG   KPG    +G  G+     P G+     LPG  FPG    +G+     
Sbjct: 1101 GAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPG--FPGSPGPMGIRGDQG 1158

Query: 157  -PGVPTGAGVKPKA------------PGVGGA--------FAGIPG-VGPFGGPQPGVPL 194
              G+P  AG K +             PG  GA        F G+PG  G  G   P  P 
Sbjct: 1159 RDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPT 1218

Query: 195  G---YPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTG---VGPQAAAAA 248
            G   +P   P LPG   +P  TG      GP G  G+ G  G P   G   +G +    +
Sbjct: 1219 GIEGFP-GPPGLPGAI-IPGQTGNR----GPPGSRGSPGAPGPPGPPGSHVIGIKGDKGS 1272

Query: 249  AAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYG 307
                  K   G AG +   G  G PG PG +PG  G  G  G P               G
Sbjct: 1273 MGHPGPKGPPGTAGDMGPPGRLGAPGTPG-LPGPRGDPGFQGFPGVKGEKGNPGFLGSIG 1331

Query: 308  AAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGA----GIPVVPGA-GIPGA-AVPGVVSPE 361
                + P GP   PGV G PG  +  + +PG+    G P  PG  G PG    PG + P 
Sbjct: 1332 PPGPIGPKGP---PGVRGDPGT-LKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPC 1387

Query: 362  AAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGG 421
                   K  K G     G  G      G+ G PG   G  G+PG+ G  G  G P    
Sbjct: 1388 GPRGKPGKDGKPGTPGPAGEKG----NKGSKGEPG-PAGSDGLPGLKGKRGDSGSPATWT 1442

Query: 422  VPGVGISPEAQAAAAAKAAKYGLVP 446
              G   +  +Q  A     + G VP
Sbjct: 1443 TRGFVFTRHSQTTAIPSCPE-GTVP 1466


>gi|89142733 alpha 3 type IV collagen isoform 2 precursor [Homo
            sapiens]
          Length = 1637

 Score =  139 bits (351), Expect = 7e-33
 Identities = 222/765 (29%), Positives = 268/765 (35%), Gaps = 156/765 (20%)

Query: 23   PSRPGGVPGAIPG----GVPGGVFYPAL----GPGGKPLKPVPG--GLAGAGLGAGLGAF 72
            PS P GVPG+ PG    G+ G   +P L    G  G+P K   G  G  G     GL   
Sbjct: 373  PSGPPGVPGS-PGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGS 431

Query: 73   PA-------VTF----------PGAL-------VPGGVADAAAAYKAAKAGAGLGGVPGV 108
            P        + F          PG L       V G   +            G  G+PG+
Sbjct: 432  PGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGL 491

Query: 109  GGLGVSAGAVVPQPGAGVK--PGKVPGVGLPGVYPGGVLPGARFPGVGVLPGV------- 159
             GL    G    Q  AG+K  PG     GLPG +PG       FPG    PG+       
Sbjct: 492  PGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPG-FPG-------FPGAQGDPGLKGEKGET 543

Query: 160  --PTGAGVKPKAPGVGG--------AFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGL 209
              P G    P  PG+ G           G PGV    GP+  + L         PG  G 
Sbjct: 544  LQPEGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGS 603

Query: 210  PYTTGKL----PYGYGPGGVAGAAGKAGYPTGTG----VGPQAAAAAAAKAAAKFG---- 257
            P + G      P GYGP G  G  G  G P   G     GP+   + +       G    
Sbjct: 604  PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGP 663

Query: 258  ------AGAAGVLPGVGGAGVPGVPG--AIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAA 309
                   G  G+   +G  G PG+PG    PGI GI   G P               G  
Sbjct: 664  PGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGFPGTKGSLGCP 723

Query: 310  AGLVPGGPGFGPGVVGVPGA-GVPGVGVPGA-GIPVVPG----------AGIPG-AAVPG 356
              +  G PG  PG  G+PGA G P V +PG  G P  PG           G+PG   +PG
Sbjct: 724  GKM--GEPGL-PGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLPG 780

Query: 357  VVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGV-GAGGFPGFG--------VGVGGIPGV 407
                E          + G     G  G    G  GA G PG           G  G  G 
Sbjct: 781  TPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGD 840

Query: 408  AGVPGV--GGVPGVGGVPGVGISPEAQAAAAAKAAK-YGLVPGVGVAPGVGVAPGVGVAP 464
             G+PG+   G PG  G PG+   P  Q        + Y   PG+   PG     G+   P
Sbjct: 841  PGIPGLDRSGFPGETGSPGI---PGHQGEMGPLGQRGYPGNPGILGPPGEDGVIGMMGFP 897

Query: 465  GVGLAPGVGVAPGVGVAPGVGVAPGI----GPGGVAAAAKSAAKVAAKAQLRAAAGLG-A 519
            G    PG    PG    PG   +PGI    G  G   A               +  +G  
Sbjct: 898  GAIGPPG---PPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDK 954

Query: 520  GIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGA 579
            G PGL    G PG     GVPG+    G+ G   +PG           A  PG  G LG+
Sbjct: 955  GEPGLKGFAGNPGEKGNRGVPGM---PGLKGLKGLPGP----------AGPPGPRGDLGS 1001

Query: 580  LGGVGIPG--GVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL-GVGGL---------- 626
             G  G PG  G+ G+        +K   K    G  G AG  GL G+ GL          
Sbjct: 1002 TGNPGEPGLRGIPGSMGNMGMPGSK--GKRGTLGFPGRAGRPGLPGIHGLQGDKGEPGYS 1059

Query: 627  -----GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGA 666
                 G PG  G  G+ P    K  + G    PG  L P  P GA
Sbjct: 1060 EGTRPGPPGPTGDPGL-PGDMGKKGEMGQPGPPGH-LGPAGPEGA 1102



 Score =  137 bits (346), Expect = 2e-32
 Identities = 208/704 (29%), Positives = 250/704 (35%), Gaps = 104/704 (14%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALV 82
            P+ P G PG  P G PG       G  G P  P P G AG   G    + P    PG   
Sbjct: 609  PAGPAGPPGYGPQGEPG-----LQGTQGVPGAPGPPGEAGP-RGELSVSTPVPGPPGPPG 662

Query: 83   PGGVADAAAAYKAAKAGAGLGGVPGV-GGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYP 141
            P G               G  G PG+ G LG      +P P    +PG +PG+G PG  P
Sbjct: 663  PPG-------------HPGPQGPPGIPGSLGKCGDPGLPGPDG--EPG-IPGIGFPG--P 704

Query: 142  GGVLPGARFPGVGVLPGVPTGAGVK--PKAPGVGGAFAGIPGVGPFGGPQPGVPLGYP-- 197
             G      FPG     G P   G    P  PG+ GA  G P V   GG  PG P G+P  
Sbjct: 705  PGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGA-KGEPAVAMPGG--PGTP-GFPGE 760

Query: 198  ---------IKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAA 248
                     I  P LPG  G P   G L    G  G  G  G+ G P     GP+ A   
Sbjct: 761  RGNSGEHGEIGLPGLPGLPGTPGNEG-LDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGL 819

Query: 249  AAKAAAKFGAGAAGVLPGVGGAGVPGVP-GAIPGIGGIAGVGTPAAAAAAAAAAKAAKYG 307
                  K   G  G     G  G+PG+     PG  G  G+  P          +    G
Sbjct: 820  PGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGSPGI--PGHQGEMGPLGQRGYPG 877

Query: 308  AAAGLVPGGPGFGPGVVGVPGAGVPGVGVPG-AGIPVVPG-AGIPGAAVPGVVSPEAAAK 365
                L P G     G++G PGA    +G PG  G P  PG  G PG  +PGV        
Sbjct: 878  NPGILGPPGEDGVIGMMGFPGA----IGPPGPPGNPGTPGQRGSPG--IPGVKGQRGTPG 931

Query: 366  AAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVG-----GIPGVAGVPGVGGVPGVG 420
            A  +    G  PG           G  G  GF    G     G+PG+ G+ G+ G+PG  
Sbjct: 932  AKGEQGDKG-NPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPA 990

Query: 421  GVPGVGISPEAQAAAAAKAAKYGL-----------VPGVGVAPGVGVAPGVGVAPGVGLA 469
            G PG    P     +     + GL           +PG     G    PG    PG+   
Sbjct: 991  GPPG----PRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGL--- 1043

Query: 470  PGVGVAPGVGVAPGV--GVAPG-IGPGGVAAAAKSAAKVAAKAQLRAAAGLG----AGIP 522
            PG+    G    PG   G  PG  GP G         K     Q      LG     G P
Sbjct: 1044 PGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAP 1103

Query: 523  GLGVGVGVPG-------LGVGA-----GVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAV 570
            G     G+PG       LG        G PG+    G+PGF   PG +   +  +    +
Sbjct: 1104 GSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPM-GIRGDQGRDGI 1162

Query: 571  PGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAA----AKAAQFGLVGAAGLGGLGVGGL 626
            PG  G  G  G +  P G  G   A  A   + A        + G +G AG  G   G  
Sbjct: 1163 PGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRG-PTGIE 1221

Query: 627  GVPGVGGL-GGIPPAAAAKAAKYGVAARPGFGLSPIFPGGACLG 669
            G PG  GL G I P         G    PG    P  PG   +G
Sbjct: 1222 GFPGPPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIG 1265



 Score =  133 bits (335), Expect = 5e-31
 Identities = 205/666 (30%), Positives = 246/666 (36%), Gaps = 112/666 (16%)

Query: 28  GVPGAI-PGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGG- 85
           G+PGA  P G+PG   +P  GP G P  P   G  G              FPGA+ P G 
Sbjct: 174 GLPGAPGPQGLPGPPGFP--GPVGPPGPP---GFFG--------------FPGAMGPRGP 214

Query: 86  ---VADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVK--PGKVPGVGLPGVY 140
              + +    +K  +   GL G PG  G  V      P     +K   G    +G PG  
Sbjct: 215 KGHMGERVIGHKGERGVKGLTGPPGPPGT-VIVTLTGPDNRTDLKGEKGDKGAMGEPGPP 273

Query: 141 PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKA 200
               LPG  +      PG P G   KP   GV G F G  GV    G  PG+     IK 
Sbjct: 274 GPSGLPGESYGSEKGAPGDP-GLQGKPGKDGVPG-FPGSEGVKGNRG-FPGLMGEDGIKG 330

Query: 201 PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGAG 259
            K  G  G P   G   Y Y      G  G  G P   G  GPQ  +            G
Sbjct: 331 QK--GDIGPPGFRGPTEY-YDTYQEKGDEGTPGPPGPRGARGPQGPS------------G 375

Query: 260 AAGVLPGVGGAGVPGVPGAI--PGIGGIAG---------VGTPAAAAAAAAAAKAAKYGA 308
             GV PG  G+  PG+ GA   PG+ G  G         +GTP +   A +       G 
Sbjct: 376 PPGV-PGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGP 434

Query: 309 AAGLVPGGPGF------GPGVVGVPG----AGVPGV----GVPG---AGIPVVPGA-GIP 350
                PG PG        PG  G+PG     G+PGV    G PG      P +PG  G+P
Sbjct: 435 -----PGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLP 489

Query: 351 GA-AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFG----------- 398
           G   + GV        AA      G+    G+ G P +  GA G PG             
Sbjct: 490 GLPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFP-GAQGDPGLKGEKGETLQPEG 548

Query: 399 -VGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVA 457
            VGV G PG+ G PG  G+ G+ G PGV   P  +   A    K    P     PG   +
Sbjct: 549 QVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGP-----PGDPGS 603

Query: 458 PGVGVAPGVGLAPGVGV--APGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAA 515
           PG     G    PG G    PG+    GV  APG  PG   A  +    V+         
Sbjct: 604 PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPG-PPG--EAGPRGELSVSTPVPGPPGP 660

Query: 516 GLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPG-ALAAAKAAKYGAAVPGVL 574
               G PG     G+PG     G PGL    G PG   +PG         K     PG  
Sbjct: 661 PGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPG---IPGIGFPGPPGPKGDQGFPGTK 717

Query: 575 GGLGALGGVGIPG--GVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVG 632
           G LG  G +G PG  G  G   A    A          G  G  G  G   G +G+PG+ 
Sbjct: 718 GSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSG-EHGEIGLPGLP 776

Query: 633 GLGGIP 638
           GL G P
Sbjct: 777 GLPGTP 782



 Score =  131 bits (330), Expect = 2e-30
 Identities = 218/776 (28%), Positives = 272/776 (35%), Gaps = 168/776 (21%)

Query: 7    AAPRPGVLLLLLSILHPSRPGGVPGAI----PGGVPGGVFYPALGPGGKPLKPVPGGLAG 62
            A PR G L +   +  P  P G PG      P G+PG     +LG  G P  P P G  G
Sbjct: 642  AGPR-GELSVSTPVPGPPGPPGPPGHPGPQGPPGIPG-----SLGKCGDPGLPGPDGEPG 695

Query: 63   AGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA----GLGGVPGVGGL-GVSAGA 117
                      P + FPG   PG   D          G     G  G+PG  GL G     
Sbjct: 696  ---------IPGIGFPGP--PGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGEP 744

Query: 118  VVPQPGAGVKPGKVPG----------VGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKP 167
             V  PG    PG  PG          +GLPG+ PG  LPG   PG   L G P G   +P
Sbjct: 745  AVAMPGGPGTPG-FPGERGNSGEHGEIGLPGL-PG--LPGT--PGNEGLDG-PRGDPGQP 797

Query: 168  KAPGVGG----------AFAGIPGVGPFGGPQ-----------PGVP----LGYPIK--A 200
              PG  G             G+PG+    G Q           PG+P     G+P +  +
Sbjct: 798  GPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGS 857

Query: 201  PKLPGGYGLPYTTGKLPYGYGPG--------------GVAGAAGKAGYPTGTGV------ 240
            P +PG  G     G+  Y   PG              G  GA G  G P   G       
Sbjct: 858  PGIPGHQGEMGPLGQRGYPGNPGILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGS 917

Query: 241  -------GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAI--PGIGGIAGV-GT 290
                   G +    A  +   K   G + +   +G  G PG+ G    PG  G  GV G 
Sbjct: 918  PGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGM 977

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA----GVPG-------VGVPG- 338
            P           A   G    L   G    PG+ G+PG+    G+PG       +G PG 
Sbjct: 978  PGLKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGR 1037

Query: 339  AGIPVVPGA-------GIPGAAV---PGVVSPEAAAKAAAKAAKYG--ARPG----VGVG 382
            AG P +PG        G PG +    PG   P           K G   +PG    +G  
Sbjct: 1038 AGRPGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPA 1097

Query: 383  GIPTYGVGAGGFPGF--------GVGVGGIPGVAGVPGVGGVPGVGGVPG----VGI-SP 429
            G P    G+ G PG          +G  GI G+ G PG+ G PG+ G PG    +GI   
Sbjct: 1098 G-PEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGD 1156

Query: 430  EAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG 489
            + +      A + G    +   PG    PG   A G   APG    PG   A  +G A  
Sbjct: 1157 QGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGA--MGDAGP 1214

Query: 490  IGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVP 549
             GP G+                        G PGL  G  +PG     G PG     G P
Sbjct: 1215 RGPTGIEGF--------------------PGPPGL-PGAIIPGQTGNRGPPGSRGSPGAP 1253

Query: 550  GFGAVPGA-LAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAA 608
            G    PG+ +   K  K     PG  G  G  G +G PG +   G               
Sbjct: 1254 GPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQG 1313

Query: 609  QFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
              G+ G  G  G  +G +G PG  G  G PP          + + PG    P  PG
Sbjct: 1314 FPGVKGEKGNPGF-LGSIGPPGPIGPKG-PPGVRGDPGTLKIISLPGSPGPPGTPG 1367



 Score =  110 bits (276), Expect = 3e-24
 Identities = 191/666 (28%), Positives = 228/666 (34%), Gaps = 163/666 (24%)

Query: 22   HPSRPG--GVPGAIPGGVPGGVFYP-ALGPGGKPLKP----------VPGGLAGAGLGAG 68
            +P  PG  G PG    GV G + +P A+GP G P  P          +PG     G    
Sbjct: 875  YPGNPGILGPPGE--DGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGA 932

Query: 69   LGAFPAVTFPG----ALVPGGVADAA----AAYKAAKAGAGLGGVPGVGGL-GVSAGAVV 119
             G       PG    + V G   +      A     K   G+ G+PG+ GL G+   A  
Sbjct: 933  KGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGP 992

Query: 120  PQP----GAGVKPGKVPGV-GLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGG 174
            P P    G+   PG+ PG+ G+PG      +PG++  G     G P  AG +P  PG+ G
Sbjct: 993  PGPRGDLGSTGNPGE-PGLRGIPGSMGNMGMPGSK--GKRGTLGFPGRAG-RPGLPGIHG 1048

Query: 175  AFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKL--PYGYGPGGVAGAAGKA 232
                    G   G +PG P   P   P LPG  G     G+   P   GP G  GA G  
Sbjct: 1049 LQGDKGEPGYSEGTRPGPP--GPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAPGSP 1106

Query: 233  GYPTGTGV-GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGV-GT 290
            G P   G  GP                G  G+L   G  G PG+PG  PG  G  G+ G 
Sbjct: 1107 GSPGLPGKPGPHGDLGFK---------GIKGLLGPPGIRGPPGLPG-FPGSPGPMGIRGD 1156

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG-AGVPGV-GVPG---------- 338
                     A +  + G      P GP   PG  G  G  G PG  G+PG          
Sbjct: 1157 QGRDGIPGPAGEKGETGLLRA--PPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGP 1214

Query: 339  ---AGIPVVPGA-GIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGF 394
                GI   PG  G+PGA +PG                 G+R   G  G P       G 
Sbjct: 1215 RGPTGIEGFPGPPGLPGAIIPGQTGNRGPP---------GSRGSPGAPGPP-------GP 1258

Query: 395  PGFGV-GVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPG 453
            PG  V G+ G  G  G PG  G PG  G  G                     PG   APG
Sbjct: 1259 PGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGP--------------------PGRLGAPG 1298

Query: 454  VGVAPGVGVAPGVGLAPGV-GVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLR 512
                PG    PG    PGV G     G    +G    IGP G                  
Sbjct: 1299 TPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVR------------- 1345

Query: 513  AAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPG 572
                   G PG    + +PG     G PG       PG    PG              PG
Sbjct: 1346 -------GDPGTLKIISLPGSPGPPGTPG------EPGMQGEPGP-------------PG 1379

Query: 573  VLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVG 632
              G LG  G  G PG                  K  + G  G AG  G   G  G PG  
Sbjct: 1380 PPGNLGPCGPRGKPG------------------KDGKPGTPGPAGEKG-NKGSKGEPGPA 1420

Query: 633  GLGGIP 638
            G  G+P
Sbjct: 1421 GSDGLP 1426



 Score =  107 bits (268), Expect = 3e-23
 Identities = 177/598 (29%), Positives = 218/598 (36%), Gaps = 105/598 (17%)

Query: 135 GLPGVYPGGVLPGAR-FPGVGVLPGVPTGAGVKPKAPGVGGA--FAGIPGVGPFGGPQPG 191
           G PG  PG   PG + F G   LPG P G    P  PG+ G+    GI G+  F G  PG
Sbjct: 52  GFPGP-PGS--PGQKGFTGPEGLPG-PQGPKGFPGLPGLTGSKGVRGISGLPGFSG-SPG 106

Query: 192 VPLGYPIKAPKLPGGYGLPYTTG----KLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAA 247
           +P       P   G YGL    G    K   G+   G+ G  G  G P   G+  Q  A 
Sbjct: 107 LP-----GTPGNTGPYGLVGVPGCSGSKGEQGFP--GLPGTLGYPGIPGAAGLKGQKGAP 159

Query: 248 AAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYG 307
           A  +       G  G+    G  G+PG PG  PG      VG P              +G
Sbjct: 160 AKEEDIELDAKGDPGLPGAPGPQGLPGPPG-FPG-----PVGPPGPPGF---------FG 204

Query: 308 AAAGLVPGGP--GFGPGVVGVPG-AGVPGVGVPGAGIPVVPGAGIPGAAVPGVVSPEAAA 364
               + P GP    G  V+G  G  GV G+  P          G PG  +  +  P+   
Sbjct: 205 FPGAMGPRGPKGHMGERVIGHKGERGVKGLTGP---------PGPPGTVIVTLTGPDNRT 255

Query: 365 KAAAKAAKYGA--RPG-VGVGGIP--TYG--VGAGGFPGF-----GVGVGGIPGVAGVPG 412
               +    GA   PG  G  G+P  +YG   GA G PG        GV G PG  GV G
Sbjct: 256 DLKGEKGDKGAMGEPGPPGPSGLPGESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGVKG 315

Query: 413 VGGVPGVGGVPGV-----GISPEAQAAAAAKAAKYGL-----VPGVGVAPGVGVAPGVGV 462
             G PG+ G  G+      I P            Y        PG     G     G   
Sbjct: 316 NRGFPGLMGEDGIKGQKGDIGPPGFRGPTEYYDTYQEKGDEGTPGPPGPRGARGPQGPSG 375

Query: 463 APGVGLAPGVGVAPGVGVAPG-VGVAPGIG----PGGVAAAAKSAAKVAAKAQLRAAAGL 517
            PGV  +PG    PG+  APG  G+    G    PG  A     +   A    L  + G 
Sbjct: 376 PPGVPGSPG-SSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGP 434

Query: 518 GA---------------GIPGLGVGVGVPGLGVGAGVPGL-----GVGAGVPGFGAVPGA 557
                            G+PG     G+PG+    G PGL         G PG   +PG 
Sbjct: 435 PGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGLPG- 493

Query: 558 LAAAKAAKYGAAVPGVLGGLGALGGVGIPG--GVVGA--GPAAAAAAAKAAAKAAQFGLV 613
           L   K         G+ G  G+ G  G+PG  G  GA   P       +      Q G+ 
Sbjct: 494 LHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQPEGQVGVP 553

Query: 614 GAAGL----GGLGVGGL-GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGA 666
           G  GL    G  G+ G+ G PGV GL G P    A + + G    PG   SP  PG A
Sbjct: 554 GDPGLRGQPGRKGLDGIPGTPGVKGLPG-PKGELALSGEKGDQGPPGDPGSPGSPGPA 610



 Score =  102 bits (253), Expect = 2e-21
 Identities = 147/512 (28%), Positives = 183/512 (35%), Gaps = 86/512 (16%)

Query: 23   PSRPG-----GVPGAIPGGVPG--GVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAV 75
            P  PG     G+PG  P G PG  G       PG   L+ +PG +   G+    G    +
Sbjct: 975  PGMPGLKGLKGLPG--PAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTL 1032

Query: 76   TFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVG 135
             FPG                    AG  G+PG+ GL    G   P    G +PG     G
Sbjct: 1033 GFPGR-------------------AGRPGLPGIHGLQGDKGE--PGYSEGTRPGPPGPTG 1071

Query: 136  LPGVYPGGVLP----GARFPGVGVLPGVPTGAGVKPKAPGVGG--------AFAGIPGV- 182
             PG+ PG +      G   P   + P  P GA   P +PG+ G         F GI G+ 
Sbjct: 1072 DPGL-PGDMGKKGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLL 1130

Query: 183  GPFG--GPQPGVPLGYPIKAPKLPGGYGLPYTTGK--LPYGYGPGGVAGAAGKAGYPTGT 238
            GP G  GP PG+P G+P      PG  G+    G+  +P   GP G  G  G    P G 
Sbjct: 1131 GPPGIRGP-PGLP-GFPGS----PGPMGIRGDQGRDGIP---GPAGEKGETGLLRAPPGP 1181

Query: 239  GVGPQAAAAAAAKAAAKFGA--GAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAA 296
               P A  A   + A  F    G  G +   G  G  G+ G  PG  G+ G   P     
Sbjct: 1182 RGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEG-FPGPPGLPGAIIPGQTGN 1240

Query: 297  AAAAAKAAKYGAAAGLVPGGPGF-GPGVVGVPG----AGVPGV-GVPGAGIPVVPGAGIP 350
                      GA     PG PG  G  V+G+ G     G PG  G PG    + P   + 
Sbjct: 1241 RGPPGSRGSPGA-----PGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLG 1295

Query: 351  GAAVPGVVSPEAAAKAAAKAAKYGARPGVG-VGGI-PTYGVGAGGFPGFGVGVG------ 402
                PG+  P             G +   G +G I P   +G  G PG     G      
Sbjct: 1296 APGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRGDPGTLKIIS 1355

Query: 403  -----GIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVA 457
                 G PG  G PG+ G PG  G PG  + P        K  K G     G     G  
Sbjct: 1356 LPGSPGPPGTPGEPGMQGEPGPPGPPG-NLGPCGPRGKPGKDGKPGTPGPAGEKGNKGSK 1414

Query: 458  PGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG 489
               G A   GL PG+    G   +P      G
Sbjct: 1415 GEPGPAGSDGL-PGLKGKRGDSGSPATWTTRG 1445



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 150/505 (29%), Positives = 189/505 (37%), Gaps = 80/505 (15%)

Query: 1    MAGLTAAAPRPGVLLLLLSILHPSRPG--GVPGAIPG-GVPGGVFYPA-LGPGGKPLKPV 56
            + GL   A  PG    L S  +P  PG  G+PG++   G+PG       LG  G+  +P 
Sbjct: 983  LKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPG 1042

Query: 57   PGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA-GLGGVPG-VGGLGVS 114
              G+ G     G   +   T PG   PG   D        K G  G  G PG +G  G  
Sbjct: 1043 LPGIHGLQGDKGEPGYSEGTRPGP--PGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPE 1100

Query: 115  AGAVVP-QPGAGVKPGKVPGVGLPGVY----PGGV-----LPGARFPG----VGVL---- 156
                 P  PG   KPG    +G  G+     P G+     LPG  FPG    +G+     
Sbjct: 1101 GAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPG--FPGSPGPMGIRGDQG 1158

Query: 157  -PGVPTGAGVKPKA------------PGVGGA--------FAGIPG-VGPFGGPQPGVPL 194
              G+P  AG K +             PG  GA        F G+PG  G  G   P  P 
Sbjct: 1159 RDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPT 1218

Query: 195  G---YPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTG---VGPQAAAAA 248
            G   +P   P LPG   +P  TG      GP G  G+ G  G P   G   +G +    +
Sbjct: 1219 GIEGFP-GPPGLPGAI-IPGQTGNR----GPPGSRGSPGAPGPPGPPGSHVIGIKGDKGS 1272

Query: 249  AAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYG 307
                  K   G AG +   G  G PG PG +PG  G  G  G P               G
Sbjct: 1273 MGHPGPKGPPGTAGDMGPPGRLGAPGTPG-LPGPRGDPGFQGFPGVKGEKGNPGFLGSIG 1331

Query: 308  AAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGA----GIPVVPGA-GIPGA-AVPGVVSPE 361
                + P GP   PGV G PG  +  + +PG+    G P  PG  G PG    PG + P 
Sbjct: 1332 PPGPIGPKGP---PGVRGDPGT-LKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPC 1387

Query: 362  AAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGG 421
                   K  K G     G  G      G+ G PG   G  G+PG+ G  G  G P    
Sbjct: 1388 GPRGKPGKDGKPGTPGPAGEKG----NKGSKGEPG-PAGSDGLPGLKGKRGDSGSPATWT 1442

Query: 422  VPGVGISPEAQAAAAAKAAKYGLVP 446
              G   +  +Q  A     + G VP
Sbjct: 1443 TRGFVFTRHSQTTAIPSCPE-GTVP 1466


>gi|89142730 alpha 3 type IV collagen isoform 1 precursor [Homo
            sapiens]
          Length = 1670

 Score =  139 bits (351), Expect = 7e-33
 Identities = 222/765 (29%), Positives = 268/765 (35%), Gaps = 156/765 (20%)

Query: 23   PSRPGGVPGAIPG----GVPGGVFYPAL----GPGGKPLKPVPG--GLAGAGLGAGLGAF 72
            PS P GVPG+ PG    G+ G   +P L    G  G+P K   G  G  G     GL   
Sbjct: 373  PSGPPGVPGS-PGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGS 431

Query: 73   PA-------VTF----------PGAL-------VPGGVADAAAAYKAAKAGAGLGGVPGV 108
            P        + F          PG L       V G   +            G  G+PG+
Sbjct: 432  PGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGL 491

Query: 109  GGLGVSAGAVVPQPGAGVK--PGKVPGVGLPGVYPGGVLPGARFPGVGVLPGV------- 159
             GL    G    Q  AG+K  PG     GLPG +PG       FPG    PG+       
Sbjct: 492  PGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPG-FPG-------FPGAQGDPGLKGEKGET 543

Query: 160  --PTGAGVKPKAPGVGG--------AFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGL 209
              P G    P  PG+ G           G PGV    GP+  + L         PG  G 
Sbjct: 544  LQPEGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGS 603

Query: 210  PYTTGKL----PYGYGPGGVAGAAGKAGYPTGTG----VGPQAAAAAAAKAAAKFG---- 257
            P + G      P GYGP G  G  G  G P   G     GP+   + +       G    
Sbjct: 604  PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGP 663

Query: 258  ------AGAAGVLPGVGGAGVPGVPG--AIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAA 309
                   G  G+   +G  G PG+PG    PGI GI   G P               G  
Sbjct: 664  PGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGFPGTKGSLGCP 723

Query: 310  AGLVPGGPGFGPGVVGVPGA-GVPGVGVPGA-GIPVVPG----------AGIPG-AAVPG 356
              +  G PG  PG  G+PGA G P V +PG  G P  PG           G+PG   +PG
Sbjct: 724  GKM--GEPGL-PGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLPG 780

Query: 357  VVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGV-GAGGFPGFG--------VGVGGIPGV 407
                E          + G     G  G    G  GA G PG           G  G  G 
Sbjct: 781  TPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGD 840

Query: 408  AGVPGV--GGVPGVGGVPGVGISPEAQAAAAAKAAK-YGLVPGVGVAPGVGVAPGVGVAP 464
             G+PG+   G PG  G PG+   P  Q        + Y   PG+   PG     G+   P
Sbjct: 841  PGIPGLDRSGFPGETGSPGI---PGHQGEMGPLGQRGYPGNPGILGPPGEDGVIGMMGFP 897

Query: 465  GVGLAPGVGVAPGVGVAPGVGVAPGI----GPGGVAAAAKSAAKVAAKAQLRAAAGLG-A 519
            G    PG    PG    PG   +PGI    G  G   A               +  +G  
Sbjct: 898  GAIGPPG---PPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDK 954

Query: 520  GIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGA 579
            G PGL    G PG     GVPG+    G+ G   +PG           A  PG  G LG+
Sbjct: 955  GEPGLKGFAGNPGEKGNRGVPGM---PGLKGLKGLPGP----------AGPPGPRGDLGS 1001

Query: 580  LGGVGIPG--GVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL-GVGGL---------- 626
             G  G PG  G+ G+        +K   K    G  G AG  GL G+ GL          
Sbjct: 1002 TGNPGEPGLRGIPGSMGNMGMPGSK--GKRGTLGFPGRAGRPGLPGIHGLQGDKGEPGYS 1059

Query: 627  -----GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGA 666
                 G PG  G  G+ P    K  + G    PG  L P  P GA
Sbjct: 1060 EGTRPGPPGPTGDPGL-PGDMGKKGEMGQPGPPGH-LGPAGPEGA 1102



 Score =  137 bits (346), Expect = 2e-32
 Identities = 208/704 (29%), Positives = 250/704 (35%), Gaps = 104/704 (14%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALV 82
            P+ P G PG  P G PG       G  G P  P P G AG   G    + P    PG   
Sbjct: 609  PAGPAGPPGYGPQGEPG-----LQGTQGVPGAPGPPGEAGP-RGELSVSTPVPGPPGPPG 662

Query: 83   PGGVADAAAAYKAAKAGAGLGGVPGV-GGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYP 141
            P G               G  G PG+ G LG      +P P    +PG +PG+G PG  P
Sbjct: 663  PPG-------------HPGPQGPPGIPGSLGKCGDPGLPGPDG--EPG-IPGIGFPG--P 704

Query: 142  GGVLPGARFPGVGVLPGVPTGAGVK--PKAPGVGGAFAGIPGVGPFGGPQPGVPLGYP-- 197
             G      FPG     G P   G    P  PG+ GA  G P V   GG  PG P G+P  
Sbjct: 705  PGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGA-KGEPAVAMPGG--PGTP-GFPGE 760

Query: 198  ---------IKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAA 248
                     I  P LPG  G P   G L    G  G  G  G+ G P     GP+ A   
Sbjct: 761  RGNSGEHGEIGLPGLPGLPGTPGNEG-LDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGL 819

Query: 249  AAKAAAKFGAGAAGVLPGVGGAGVPGVP-GAIPGIGGIAGVGTPAAAAAAAAAAKAAKYG 307
                  K   G  G     G  G+PG+     PG  G  G+  P          +    G
Sbjct: 820  PGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGSPGI--PGHQGEMGPLGQRGYPG 877

Query: 308  AAAGLVPGGPGFGPGVVGVPGAGVPGVGVPG-AGIPVVPG-AGIPGAAVPGVVSPEAAAK 365
                L P G     G++G PGA    +G PG  G P  PG  G PG  +PGV        
Sbjct: 878  NPGILGPPGEDGVIGMMGFPGA----IGPPGPPGNPGTPGQRGSPG--IPGVKGQRGTPG 931

Query: 366  AAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVG-----GIPGVAGVPGVGGVPGVG 420
            A  +    G  PG           G  G  GF    G     G+PG+ G+ G+ G+PG  
Sbjct: 932  AKGEQGDKG-NPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPA 990

Query: 421  GVPGVGISPEAQAAAAAKAAKYGL-----------VPGVGVAPGVGVAPGVGVAPGVGLA 469
            G PG    P     +     + GL           +PG     G    PG    PG+   
Sbjct: 991  GPPG----PRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGL--- 1043

Query: 470  PGVGVAPGVGVAPGV--GVAPG-IGPGGVAAAAKSAAKVAAKAQLRAAAGLG----AGIP 522
            PG+    G    PG   G  PG  GP G         K     Q      LG     G P
Sbjct: 1044 PGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAP 1103

Query: 523  GLGVGVGVPG-------LGVGA-----GVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAV 570
            G     G+PG       LG        G PG+    G+PGF   PG +   +  +    +
Sbjct: 1104 GSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPM-GIRGDQGRDGI 1162

Query: 571  PGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAA----AKAAQFGLVGAAGLGGLGVGGL 626
            PG  G  G  G +  P G  G   A  A   + A        + G +G AG  G   G  
Sbjct: 1163 PGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRG-PTGIE 1221

Query: 627  GVPGVGGL-GGIPPAAAAKAAKYGVAARPGFGLSPIFPGGACLG 669
            G PG  GL G I P         G    PG    P  PG   +G
Sbjct: 1222 GFPGPPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIG 1265



 Score =  133 bits (335), Expect = 5e-31
 Identities = 205/666 (30%), Positives = 246/666 (36%), Gaps = 112/666 (16%)

Query: 28  GVPGAI-PGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGG- 85
           G+PGA  P G+PG   +P  GP G P  P   G  G              FPGA+ P G 
Sbjct: 174 GLPGAPGPQGLPGPPGFP--GPVGPPGPP---GFFG--------------FPGAMGPRGP 214

Query: 86  ---VADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVK--PGKVPGVGLPGVY 140
              + +    +K  +   GL G PG  G  V      P     +K   G    +G PG  
Sbjct: 215 KGHMGERVIGHKGERGVKGLTGPPGPPGT-VIVTLTGPDNRTDLKGEKGDKGAMGEPGPP 273

Query: 141 PGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKA 200
               LPG  +      PG P G   KP   GV G F G  GV    G  PG+     IK 
Sbjct: 274 GPSGLPGESYGSEKGAPGDP-GLQGKPGKDGVPG-FPGSEGVKGNRG-FPGLMGEDGIKG 330

Query: 201 PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKAAAKFGAG 259
            K  G  G P   G   Y Y      G  G  G P   G  GPQ  +            G
Sbjct: 331 QK--GDIGPPGFRGPTEY-YDTYQEKGDEGTPGPPGPRGARGPQGPS------------G 375

Query: 260 AAGVLPGVGGAGVPGVPGAI--PGIGGIAG---------VGTPAAAAAAAAAAKAAKYGA 308
             GV PG  G+  PG+ GA   PG+ G  G         +GTP +   A +       G 
Sbjct: 376 PPGV-PGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGP 434

Query: 309 AAGLVPGGPGF------GPGVVGVPG----AGVPGV----GVPG---AGIPVVPGA-GIP 350
                PG PG        PG  G+PG     G+PGV    G PG      P +PG  G+P
Sbjct: 435 -----PGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLP 489

Query: 351 GA-AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFG----------- 398
           G   + GV        AA      G+    G+ G P +  GA G PG             
Sbjct: 490 GLPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFP-GAQGDPGLKGEKGETLQPEG 548

Query: 399 -VGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVA 457
            VGV G PG+ G PG  G+ G+ G PGV   P  +   A    K    P     PG   +
Sbjct: 549 QVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGP-----PGDPGS 603

Query: 458 PGVGVAPGVGLAPGVGV--APGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAA 515
           PG     G    PG G    PG+    GV  APG  PG   A  +    V+         
Sbjct: 604 PGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPG-PPG--EAGPRGELSVSTPVPGPPGP 660

Query: 516 GLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPG-ALAAAKAAKYGAAVPGVL 574
               G PG     G+PG     G PGL    G PG   +PG         K     PG  
Sbjct: 661 PGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPG---IPGIGFPGPPGPKGDQGFPGTK 717

Query: 575 GGLGALGGVGIPG--GVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVG 632
           G LG  G +G PG  G  G   A    A          G  G  G  G   G +G+PG+ 
Sbjct: 718 GSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSG-EHGEIGLPGLP 776

Query: 633 GLGGIP 638
           GL G P
Sbjct: 777 GLPGTP 782



 Score =  131 bits (330), Expect = 2e-30
 Identities = 218/776 (28%), Positives = 272/776 (35%), Gaps = 168/776 (21%)

Query: 7    AAPRPGVLLLLLSILHPSRPGGVPGAI----PGGVPGGVFYPALGPGGKPLKPVPGGLAG 62
            A PR G L +   +  P  P G PG      P G+PG     +LG  G P  P P G  G
Sbjct: 642  AGPR-GELSVSTPVPGPPGPPGPPGHPGPQGPPGIPG-----SLGKCGDPGLPGPDGEPG 695

Query: 63   AGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA----GLGGVPGVGGL-GVSAGA 117
                      P + FPG   PG   D          G     G  G+PG  GL G     
Sbjct: 696  ---------IPGIGFPGP--PGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGEP 744

Query: 118  VVPQPGAGVKPGKVPG----------VGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKP 167
             V  PG    PG  PG          +GLPG+ PG  LPG   PG   L G P G   +P
Sbjct: 745  AVAMPGGPGTPG-FPGERGNSGEHGEIGLPGL-PG--LPGT--PGNEGLDG-PRGDPGQP 797

Query: 168  KAPGVGG----------AFAGIPGVGPFGGPQ-----------PGVP----LGYPIK--A 200
              PG  G             G+PG+    G Q           PG+P     G+P +  +
Sbjct: 798  GPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGS 857

Query: 201  PKLPGGYGLPYTTGKLPYGYGPG--------------GVAGAAGKAGYPTGTGV------ 240
            P +PG  G     G+  Y   PG              G  GA G  G P   G       
Sbjct: 858  PGIPGHQGEMGPLGQRGYPGNPGILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGS 917

Query: 241  -------GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAI--PGIGGIAGV-GT 290
                   G +    A  +   K   G + +   +G  G PG+ G    PG  G  GV G 
Sbjct: 918  PGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGM 977

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA----GVPG-------VGVPG- 338
            P           A   G    L   G    PG+ G+PG+    G+PG       +G PG 
Sbjct: 978  PGLKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGR 1037

Query: 339  AGIPVVPGA-------GIPGAAV---PGVVSPEAAAKAAAKAAKYG--ARPG----VGVG 382
            AG P +PG        G PG +    PG   P           K G   +PG    +G  
Sbjct: 1038 AGRPGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPA 1097

Query: 383  GIPTYGVGAGGFPGF--------GVGVGGIPGVAGVPGVGGVPGVGGVPG----VGI-SP 429
            G P    G+ G PG          +G  GI G+ G PG+ G PG+ G PG    +GI   
Sbjct: 1098 G-PEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGD 1156

Query: 430  EAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG 489
            + +      A + G    +   PG    PG   A G   APG    PG   A  +G A  
Sbjct: 1157 QGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGA--MGDAGP 1214

Query: 490  IGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVP 549
             GP G+                        G PGL  G  +PG     G PG     G P
Sbjct: 1215 RGPTGIEGF--------------------PGPPGL-PGAIIPGQTGNRGPPGSRGSPGAP 1253

Query: 550  GFGAVPGA-LAAAKAAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAA 608
            G    PG+ +   K  K     PG  G  G  G +G PG +   G               
Sbjct: 1254 GPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQG 1313

Query: 609  QFGLVGAAGLGGLGVGGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
              G+ G  G  G  +G +G PG  G  G PP          + + PG    P  PG
Sbjct: 1314 FPGVKGEKGNPGF-LGSIGPPGPIGPKG-PPGVRGDPGTLKIISLPGSPGPPGTPG 1367



 Score =  110 bits (276), Expect = 3e-24
 Identities = 191/666 (28%), Positives = 228/666 (34%), Gaps = 163/666 (24%)

Query: 22   HPSRPG--GVPGAIPGGVPGGVFYP-ALGPGGKPLKP----------VPGGLAGAGLGAG 68
            +P  PG  G PG    GV G + +P A+GP G P  P          +PG     G    
Sbjct: 875  YPGNPGILGPPGE--DGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGA 932

Query: 69   LGAFPAVTFPG----ALVPGGVADAA----AAYKAAKAGAGLGGVPGVGGL-GVSAGAVV 119
             G       PG    + V G   +      A     K   G+ G+PG+ GL G+   A  
Sbjct: 933  KGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGP 992

Query: 120  PQP----GAGVKPGKVPGV-GLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGG 174
            P P    G+   PG+ PG+ G+PG      +PG++  G     G P  AG +P  PG+ G
Sbjct: 993  PGPRGDLGSTGNPGE-PGLRGIPGSMGNMGMPGSK--GKRGTLGFPGRAG-RPGLPGIHG 1048

Query: 175  AFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKL--PYGYGPGGVAGAAGKA 232
                    G   G +PG P   P   P LPG  G     G+   P   GP G  GA G  
Sbjct: 1049 LQGDKGEPGYSEGTRPGPP--GPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAPGSP 1106

Query: 233  GYPTGTGV-GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGV-GT 290
            G P   G  GP                G  G+L   G  G PG+PG  PG  G  G+ G 
Sbjct: 1107 GSPGLPGKPGPHGDLGFK---------GIKGLLGPPGIRGPPGLPG-FPGSPGPMGIRGD 1156

Query: 291  PAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG-AGVPGV-GVPG---------- 338
                     A +  + G      P GP   PG  G  G  G PG  G+PG          
Sbjct: 1157 QGRDGIPGPAGEKGETGLLRA--PPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGP 1214

Query: 339  ---AGIPVVPGA-GIPGAAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGF 394
                GI   PG  G+PGA +PG                 G+R   G  G P       G 
Sbjct: 1215 RGPTGIEGFPGPPGLPGAIIPGQTGNRGPP---------GSRGSPGAPGPP-------GP 1258

Query: 395  PGFGV-GVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPG 453
            PG  V G+ G  G  G PG  G PG  G  G                     PG   APG
Sbjct: 1259 PGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGP--------------------PGRLGAPG 1298

Query: 454  VGVAPGVGVAPGVGLAPGV-GVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLR 512
                PG    PG    PGV G     G    +G    IGP G                  
Sbjct: 1299 TPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVR------------- 1345

Query: 513  AAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPG 572
                   G PG    + +PG     G PG       PG    PG              PG
Sbjct: 1346 -------GDPGTLKIISLPGSPGPPGTPG------EPGMQGEPGP-------------PG 1379

Query: 573  VLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVG 632
              G LG  G  G PG                  K  + G  G AG  G   G  G PG  
Sbjct: 1380 PPGNLGPCGPRGKPG------------------KDGKPGTPGPAGEKG-NKGSKGEPGPA 1420

Query: 633  GLGGIP 638
            G  G+P
Sbjct: 1421 GSDGLP 1426



 Score =  107 bits (268), Expect = 3e-23
 Identities = 177/598 (29%), Positives = 218/598 (36%), Gaps = 105/598 (17%)

Query: 135 GLPGVYPGGVLPGAR-FPGVGVLPGVPTGAGVKPKAPGVGGA--FAGIPGVGPFGGPQPG 191
           G PG  PG   PG + F G   LPG P G    P  PG+ G+    GI G+  F G  PG
Sbjct: 52  GFPGP-PGS--PGQKGFTGPEGLPG-PQGPKGFPGLPGLTGSKGVRGISGLPGFSG-SPG 106

Query: 192 VPLGYPIKAPKLPGGYGLPYTTG----KLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAA 247
           +P       P   G YGL    G    K   G+   G+ G  G  G P   G+  Q  A 
Sbjct: 107 LP-----GTPGNTGPYGLVGVPGCSGSKGEQGFP--GLPGTLGYPGIPGAAGLKGQKGAP 159

Query: 248 AAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYG 307
           A  +       G  G+    G  G+PG PG  PG      VG P              +G
Sbjct: 160 AKEEDIELDAKGDPGLPGAPGPQGLPGPPG-FPG-----PVGPPGPPGF---------FG 204

Query: 308 AAAGLVPGGP--GFGPGVVGVPG-AGVPGVGVPGAGIPVVPGAGIPGAAVPGVVSPEAAA 364
               + P GP    G  V+G  G  GV G+  P          G PG  +  +  P+   
Sbjct: 205 FPGAMGPRGPKGHMGERVIGHKGERGVKGLTGP---------PGPPGTVIVTLTGPDNRT 255

Query: 365 KAAAKAAKYGA--RPG-VGVGGIP--TYG--VGAGGFPGF-----GVGVGGIPGVAGVPG 412
               +    GA   PG  G  G+P  +YG   GA G PG        GV G PG  GV G
Sbjct: 256 DLKGEKGDKGAMGEPGPPGPSGLPGESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGVKG 315

Query: 413 VGGVPGVGGVPGV-----GISPEAQAAAAAKAAKYGL-----VPGVGVAPGVGVAPGVGV 462
             G PG+ G  G+      I P            Y        PG     G     G   
Sbjct: 316 NRGFPGLMGEDGIKGQKGDIGPPGFRGPTEYYDTYQEKGDEGTPGPPGPRGARGPQGPSG 375

Query: 463 APGVGLAPGVGVAPGVGVAPG-VGVAPGIG----PGGVAAAAKSAAKVAAKAQLRAAAGL 517
            PGV  +PG    PG+  APG  G+    G    PG  A     +   A    L  + G 
Sbjct: 376 PPGVPGSPG-SSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGP 434

Query: 518 GA---------------GIPGLGVGVGVPGLGVGAGVPGL-----GVGAGVPGFGAVPGA 557
                            G+PG     G+PG+    G PGL         G PG   +PG 
Sbjct: 435 PGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGLPG- 493

Query: 558 LAAAKAAKYGAAVPGVLGGLGALGGVGIPG--GVVGA--GPAAAAAAAKAAAKAAQFGLV 613
           L   K         G+ G  G+ G  G+PG  G  GA   P       +      Q G+ 
Sbjct: 494 LHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQPEGQVGVP 553

Query: 614 GAAGL----GGLGVGGL-GVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPGGA 666
           G  GL    G  G+ G+ G PGV GL G P    A + + G    PG   SP  PG A
Sbjct: 554 GDPGLRGQPGRKGLDGIPGTPGVKGLPG-PKGELALSGEKGDQGPPGDPGSPGSPGPA 610



 Score =  102 bits (253), Expect = 2e-21
 Identities = 147/512 (28%), Positives = 183/512 (35%), Gaps = 86/512 (16%)

Query: 23   PSRPG-----GVPGAIPGGVPG--GVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAV 75
            P  PG     G+PG  P G PG  G       PG   L+ +PG +   G+    G    +
Sbjct: 975  PGMPGLKGLKGLPG--PAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTL 1032

Query: 76   TFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVG 135
             FPG                    AG  G+PG+ GL    G   P    G +PG     G
Sbjct: 1033 GFPGR-------------------AGRPGLPGIHGLQGDKGE--PGYSEGTRPGPPGPTG 1071

Query: 136  LPGVYPGGVLP----GARFPGVGVLPGVPTGAGVKPKAPGVGG--------AFAGIPGV- 182
             PG+ PG +      G   P   + P  P GA   P +PG+ G         F GI G+ 
Sbjct: 1072 DPGL-PGDMGKKGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLL 1130

Query: 183  GPFG--GPQPGVPLGYPIKAPKLPGGYGLPYTTGK--LPYGYGPGGVAGAAGKAGYPTGT 238
            GP G  GP PG+P G+P      PG  G+    G+  +P   GP G  G  G    P G 
Sbjct: 1131 GPPGIRGP-PGLP-GFPGS----PGPMGIRGDQGRDGIP---GPAGEKGETGLLRAPPGP 1181

Query: 239  GVGPQAAAAAAAKAAAKFGA--GAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAA 296
               P A  A   + A  F    G  G +   G  G  G+ G  PG  G+ G   P     
Sbjct: 1182 RGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEG-FPGPPGLPGAIIPGQTGN 1240

Query: 297  AAAAAKAAKYGAAAGLVPGGPGF-GPGVVGVPG----AGVPGV-GVPGAGIPVVPGAGIP 350
                      GA     PG PG  G  V+G+ G     G PG  G PG    + P   + 
Sbjct: 1241 RGPPGSRGSPGA-----PGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLG 1295

Query: 351  GAAVPGVVSPEAAAKAAAKAAKYGARPGVG-VGGI-PTYGVGAGGFPGFGVGVG------ 402
                PG+  P             G +   G +G I P   +G  G PG     G      
Sbjct: 1296 APGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRGDPGTLKIIS 1355

Query: 403  -----GIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVA 457
                 G PG  G PG+ G PG  G PG  + P        K  K G     G     G  
Sbjct: 1356 LPGSPGPPGTPGEPGMQGEPGPPGPPG-NLGPCGPRGKPGKDGKPGTPGPAGEKGNKGSK 1414

Query: 458  PGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG 489
               G A   GL PG+    G   +P      G
Sbjct: 1415 GEPGPAGSDGL-PGLKGKRGDSGSPATWTTRG 1445



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 150/505 (29%), Positives = 189/505 (37%), Gaps = 80/505 (15%)

Query: 1    MAGLTAAAPRPGVLLLLLSILHPSRPG--GVPGAIPG-GVPGGVFYPA-LGPGGKPLKPV 56
            + GL   A  PG    L S  +P  PG  G+PG++   G+PG       LG  G+  +P 
Sbjct: 983  LKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPG 1042

Query: 57   PGGLAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA-GLGGVPG-VGGLGVS 114
              G+ G     G   +   T PG   PG   D        K G  G  G PG +G  G  
Sbjct: 1043 LPGIHGLQGDKGEPGYSEGTRPGP--PGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPE 1100

Query: 115  AGAVVP-QPGAGVKPGKVPGVGLPGVY----PGGV-----LPGARFPG----VGVL---- 156
                 P  PG   KPG    +G  G+     P G+     LPG  FPG    +G+     
Sbjct: 1101 GAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPG--FPGSPGPMGIRGDQG 1158

Query: 157  -PGVPTGAGVKPKA------------PGVGGA--------FAGIPG-VGPFGGPQPGVPL 194
              G+P  AG K +             PG  GA        F G+PG  G  G   P  P 
Sbjct: 1159 RDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPT 1218

Query: 195  G---YPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTG---VGPQAAAAA 248
            G   +P   P LPG   +P  TG      GP G  G+ G  G P   G   +G +    +
Sbjct: 1219 GIEGFP-GPPGLPGAI-IPGQTGNR----GPPGSRGSPGAPGPPGPPGSHVIGIKGDKGS 1272

Query: 249  AAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYG 307
                  K   G AG +   G  G PG PG +PG  G  G  G P               G
Sbjct: 1273 MGHPGPKGPPGTAGDMGPPGRLGAPGTPG-LPGPRGDPGFQGFPGVKGEKGNPGFLGSIG 1331

Query: 308  AAAGLVPGGPGFGPGVVGVPGAGVPGVGVPGA----GIPVVPGA-GIPGA-AVPGVVSPE 361
                + P GP   PGV G PG  +  + +PG+    G P  PG  G PG    PG + P 
Sbjct: 1332 PPGPIGPKGP---PGVRGDPGT-LKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPC 1387

Query: 362  AAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGG 421
                   K  K G     G  G      G+ G PG   G  G+PG+ G  G  G P    
Sbjct: 1388 GPRGKPGKDGKPGTPGPAGEKG----NKGSKGEPG-PAGSDGLPGLKGKRGDSGSPATWT 1442

Query: 422  VPGVGISPEAQAAAAAKAAKYGLVP 446
              G   +  +Q  A     + G VP
Sbjct: 1443 TRGFVFTRHSQTTAIPSCPE-GTVP 1466


>gi|100913220 alpha 1 type XVI collagen precursor [Homo sapiens]
          Length = 1604

 Score =  139 bits (350), Expect = 9e-33
 Identities = 219/714 (30%), Positives = 257/714 (35%), Gaps = 126/714 (17%)

Query: 23   PSRPGGVPGAI-PGGVPGGVFYPALGPGGKPLKPVPG--GLAGA-GLGAGLGAFPAVTFP 78
            P  P G+PG   P GVPG             L+ VPG  GL G  GL A LG+ P     
Sbjct: 905  PQGPPGIPGPPGPPGVPG-------------LQGVPGNNGLPGQPGLTAELGSLPIEQHL 951

Query: 79   GALVPGGVADAAAA---YKAAKAGAGLGGVPGVGGLGVSAGAVVP--QPGAGVK------ 127
               + G       A   Y   K   G  G+PGV GL   A   +   +P A         
Sbjct: 952  LKSICGDCVQGQRAHPGYLVEKGEKGDQGIPGVPGLDNCAQCFLSLERPRAEEARGDNSE 1011

Query: 128  --PGKVPGVGLPGVYPGGVLPGARF----PGVGVLPGVPTGAGVKPKAPGVGGAFAGIPG 181
              PG V   GLPG  PG  LPG R     PG+   PG P   G     PG  GA  G PG
Sbjct: 1012 GDPGCVGSPGLPGP-PG--LPGQRGEEGPPGMRGSPGPPGPIG----PPGFPGA-VGSPG 1063

Query: 182  VGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGK--LPYGYGPGGVAGAAGKAGYPTGTG 239
            +    G +    L      P  PG  G P  TG   LP   G  G  G+AG+ G P   G
Sbjct: 1064 LPGLQGERGLTGLTGDKGEPGPPGQPGYPGATGPPGLPGIKGERGYTGSAGEKGEPGPPG 1123

Query: 240  V----GPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAA 295
                 GP   A    +   +  +G  G     G  G PG PG  PG  G   VG+P    
Sbjct: 1124 SEGLPGPPGPAGPRGERGPQGNSGEKGDQGFQGQPGFPGPPGP-PGFPG--KVGSPGPPG 1180

Query: 296  AAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG-AGVPGV----GVPGAGIPVVPGAGIP 350
              A        G +   +PG PG  PG  G+ G AG+ G+    G PG         G P
Sbjct: 1181 PQAEKGSEGIRGPSG--LPGSPG-PPGPPGIQGPAGLDGLDGKDGKPGL-------RGDP 1230

Query: 351  G-AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIP--TYGVGAGGFPGF--GVGVGGIP 405
            G A  PG++ P             G +   G  G P  T   GA G PG     G  G P
Sbjct: 1231 GPAGPPGLMGPPGFKGKTGHPGLPGPKGDCGKPGPPGSTGRPGAEGEPGAMGPQGRPGPP 1290

Query: 406  GVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPG 465
            G  G PG  G PG  G+  VG+  +  A             G+   PG    PG    PG
Sbjct: 1291 GHVGPPGPPGQPGPAGISAVGLKGDRGATGER---------GLAGLPGQPGPPGHPGPPG 1341

Query: 466  VGLAPGVGVAPGVGVAPG-VGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGL 524
                PG   A G    PG  G     GP G   AA    +   K   RA    G G  G 
Sbjct: 1342 ---EPGTDGAAGKEGPPGKQGFYGPPGPKGDPGAAGQKGQAGEKG--RAGMPGGPGKSGS 1396

Query: 525  GVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALA--------------------AAKAA 564
               VG PG     G PG    +G PG   VPG++                       + A
Sbjct: 1397 MGPVGPPGPAGERGHPGAPGPSGSPGLPGVPGSMGDMVNYDEIKRFIRQEIIKMFDERMA 1456

Query: 565  KYG---------AAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGA 615
             Y          AA PG  G  G  G  G PG      P +     +   +  Q GL G 
Sbjct: 1457 YYTSRMQFPMEMAAAPGRPGPPGKDGAPGRPG-----APGSPGLPGQIGREGRQ-GLPGV 1510

Query: 616  AGLGGL----GVGGLGVPGVGGLGGIP-PAAAAKAAKYGVAARPGFGLSPIFPG 664
             GL G     G  G+G+ G  GL G P P       K G     G    P  PG
Sbjct: 1511 RGLPGTKGEKGDIGIGIAGENGLPGPPGPQGPPGYGKMGATGPMGQQGIPGIPG 1564



 Score =  129 bits (324), Expect = 9e-30
 Identities = 218/761 (28%), Positives = 257/761 (33%), Gaps = 141/761 (18%)

Query: 23   PSRPGGVPGAIPGGVPGGVFYPAL-GPGGKPLKPVPGGLAG------AGLGAGLGAFPAV 75
            P  PGG PG  P G  G    P   GPGGKP KP   G  G        L  G   F  V
Sbjct: 466  PGDPGGPPG--PKGDKGSSGIPGKEGPGGKPGKPGVKGEKGDPCEVCPTLPEGFQNF--V 521

Query: 76   TFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLG----VSAGAVVPQPGAGVKPGKV 131
              PG   P G        +      G+ G  G   L     V A  +V   GA    G  
Sbjct: 522  GLPGKPGPKGEPGDPVPARGDPGIQGIKGEKGEPCLSCSSVVGAQHLVSSTGASGDVGS- 580

Query: 132  PGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGV--------- 182
            PG GLPG+     +PG +          P G+   P  PG  G  AGI G          
Sbjct: 581  PGFGLPGLPGRAGVPGLKGEKGNFGEAGPAGS---PGPPGPVGP-AGIKGAKGEPCEPCP 636

Query: 183  ----------------GPFGGP-QPGVP-LGYPIKAPKL--------------PGGYGLP 210
                            GP G   +PG P  G P K  K               PG  G P
Sbjct: 637  ALSNLQDGDVRVVALPGPSGEKGEPGPPGFGLPGKQGKAGERGLKGQKGDAGNPGDPGTP 696

Query: 211  YTTGKLPYGYGPGGVAGAAGKAGYP-TGTGVGPQAAAAAAAKAAAKFGAGAAGVL--PGV 267
             TTG+ P   G  GV G AG  G    G    P         A      G  G     GV
Sbjct: 697  GTTGR-PGLSGEPGVQGPAGPKGEKGDGCTACPSLQGTVTDMAGRPGQPGPKGEQGPEGV 755

Query: 268  GGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVP 327
            G  G PG PG +PG+ G  G+                  G      PG PG  PG+ G+P
Sbjct: 756  GRPGKPGQPG-LPGVQGPPGLKGVQGEPGPPGRGVQGPQGE-----PGAPGL-PGIQGLP 808

Query: 328  GA-GVPG-VGVPGA-GIPVVPGA----GIPGAAV---PGVVSPEAAAKAAAKAAKYGARP 377
            G  G PG  G  GA G P V GA    G PGA+V   PG    +          + G R 
Sbjct: 809  GPRGPPGPTGEKGAQGSPGVKGATGPVGPPGASVSGPPGRDGQQGQTGLRGTPGEKGPRG 868

Query: 378  GVGVGG---IPTYG----VGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISP- 429
              G  G    P+ G     G  G PG  +G    PG  G PG+ G PG  GVPG+   P 
Sbjct: 869  EKGEPGECSCPSQGDLIFSGMPGAPGLWMGSSWQPGPQGPPGIPGPPGPPGVPGLQGVPG 928

Query: 430  -EAQAAAAAKAAKYGLVP---------------GVGVAPGVGVAPGVGVAPGVGLAPGVG 473
                       A+ G +P               G    PG  V  G     G+   PG+ 
Sbjct: 929  NNGLPGQPGLTAELGSLPIEQHLLKSICGDCVQGQRAHPGYLVEKGEKGDQGIPGVPGLD 988

Query: 474  VA-----------------------PGVGVAPGVGVAPGI-------GPGGVAAAAKSAA 503
                                     PG   +PG+   PG+       GP G+  +     
Sbjct: 989  NCAQCFLSLERPRAEEARGDNSEGDPGCVGSPGLPGPPGLPGQRGEEGPPGMRGSPGPPG 1048

Query: 504  KVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKA 563
             +        A G   G+PGL    G+ GL    G PG     G PG    PG L   K 
Sbjct: 1049 PIGPPG-FPGAVG-SPGLPGLQGERGLTGLTGDKGEPGPPGQPGYPGATGPPG-LPGIKG 1105

Query: 564  AKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGV 623
             +      G  G  G  G  G+PG    AGP         + +    G  G  G  G   
Sbjct: 1106 ERGYTGSAGEKGEPGPPGSEGLPGPPGPAGPRGERGPQGNSGEKGDQGFQGQPGFPG-PP 1164

Query: 624  GGLGVPGVGGLGGIPPAAAAKAAKYGVAARPGFGLSPIFPG 664
            G  G PG  G  G PP   A+    G+    G   SP  PG
Sbjct: 1165 GPPGFPGKVGSPG-PPGPQAEKGSEGIRGPSGLPGSPGPPG 1204



 Score =  115 bits (289), Expect = 1e-25
 Identities = 195/686 (28%), Positives = 231/686 (33%), Gaps = 125/686 (18%)

Query: 30  PGAIPGGVPGGVFYPALGP-GGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGVAD 88
           P  + G     V     GP GGK  + +PG     G     G       P A  P   A+
Sbjct: 317 PPCVHGARDSNVTLAPSGPKGGKGERGLPGPPGSKGEKGARGNDCVRISPDA--PLQCAE 374

Query: 89  AAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPGKVPGVGLPGVYPGGVLPGA 148
                K      G  G+PG  G     G    +   G+K       G+PG          
Sbjct: 375 GPKGEKGESGALGPSGLPGSTG---EKGQKGEKGDGGIK-------GVPGK--------- 415

Query: 149 RFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYG 208
             PG    PG     G  PK       F G  G+    GP PG+P          P G G
Sbjct: 416 --PGRDGRPGEICVIG--PKGQKGDPGFVGPEGLAGEPGP-PGLPG---------PPGIG 461

Query: 209 LPYTTGKLPYG-------YGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAA 261
           LP T G  P G        G  G+ G  G  G P   GV  +             G    
Sbjct: 462 LPGTPGD-PGGPPGPKGDKGSSGIPGKEGPGGKPGKPGVKGEKGDPCEVCPTLPEGFQNF 520

Query: 262 GVLPG-VGGAGVPGVP---GAIPGIGGIAG-VGTPAAAAAAAAAAKAAKYGAAAGLVPGG 316
             LPG  G  G PG P      PGI GI G  G P  + ++   A+       A    G 
Sbjct: 521 VGLPGKPGPKGEPGDPVPARGDPGIQGIKGEKGEPCLSCSSVVGAQHLVSSTGASGDVGS 580

Query: 317 PGFGPGVVGVPG-AGVPGV-------------GVPGAGIPVVPGAGIPGAAVPGVVSPEA 362
           PGF  G+ G+PG AGVPG+             G PG   PV P AGI GA         A
Sbjct: 581 PGF--GLPGLPGRAGVPGLKGEKGNFGEAGPAGSPGPPGPVGP-AGIKGAKGEPCEPCPA 637

Query: 363 AAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPGFGV----------GVGGIPGVAGVPG 412
            +       +  A PG      P+   G  G PGFG+          G+ G  G AG PG
Sbjct: 638 LSNLQDGDVRVVALPG------PSGEKGEPGPPGFGLPGKQGKAGERGLKGQKGDAGNPG 691

Query: 413 VGGVPGVGGVPGVGISPEAQAAAAAKAAK----------YGLVPGVGVAPGVGVAPGVGV 462
             G PG  G PG+   P  Q  A  K  K           G V  +   PG     G   
Sbjct: 692 DPGTPGTTGRPGLSGEPGVQGPAGPKGEKGDGCTACPSLQGTVTDMAGRPGQPGPKGEQG 751

Query: 463 APGVGL--APGVGVAPGVGVAPGV-GVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGA 519
             GVG    PG    PGV   PG+ GV    GP G                         
Sbjct: 752 PEGVGRPGKPGQPGLPGVQGPPGLKGVQGEPGPPGRGVQGPQGE---------------P 796

Query: 520 GIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGA 579
           G PGL    G+ GL    G PG     G  G   V G  A       GA+V G  G  G 
Sbjct: 797 GAPGL---PGIQGLPGPRGPPGPTGEKGAQGSPGVKG--ATGPVGPPGASVSGPPGRDGQ 851

Query: 580 LGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLV--GAAGLGGLGVGGLGVPGVGGLGGI 637
            G  G+ G     GP          +  +Q  L+  G  G  GL +G    PG  G  GI
Sbjct: 852 QGQTGLRGTPGEKGPRGEKGEPGECSCPSQGDLIFSGMPGAPGLWMGSSWQPGPQGPPGI 911

Query: 638 P--------PAAAAKAAKYGVAARPG 655
           P        P         G+  +PG
Sbjct: 912 PGPPGPPGVPGLQGVPGNNGLPGQPG 937



 Score =  104 bits (260), Expect = 2e-22
 Identities = 163/538 (30%), Positives = 198/538 (36%), Gaps = 91/538 (16%)

Query: 28   GVPGAI-PGGVPGGVFYPALGPGGKPLKPVPG--GLAGAGLGAGLGAFPAVTFPGALVPG 84
            G PG I P G PG V  P L PG +  + + G  G  G     G   +P  T P  L PG
Sbjct: 1045 GPPGPIGPPGFPGAVGSPGL-PGLQGERGLTGLTGDKGEPGPPGQPGYPGATGPPGL-PG 1102

Query: 85   GVADAAAAYKAAKAGA----GLGGVPGVGGLGVSAGAVVPQPGAGVK------------- 127
               +      A + G     G  G+PG  G     G   PQ  +G K             
Sbjct: 1103 IKGERGYTGSAGEKGEPGPPGSEGLPGPPGPAGPRGERGPQGNSGEKGDQGFQGQPGFPG 1162

Query: 128  -------PGKVPGVGLPGVYPGGVLPGARFP-GVGVLPGVPTGAGVKPKAPGVGGAFA-- 177
                   PGKV   G PG        G R P G+   PG P   G++  A G+ G     
Sbjct: 1163 PPGPPGFPGKVGSPGPPGPQAEKGSEGIRGPSGLPGSPGPPGPPGIQGPA-GLDGLDGKD 1221

Query: 178  GIPGV----GPFGGPQPGVPLGYPIKA--------------PKLPGGYGLPYTTGKLPYG 219
            G PG+    GP G P    P G+  K               P  PG  G P   G+ P  
Sbjct: 1222 GKPGLRGDPGPAGPPGLMGPPGFKGKTGHPGLPGPKGDCGKPGPPGSTGRPGAEGE-PGA 1280

Query: 220  YGPGGVAGAAGKAGYPTGTGV-GPQAAAAAAAKA--AAKFGAGAAGVLPGVGGAGVPGVP 276
             GP G  G  G  G P   G  GP   +A   K    A    G AG+    G  G PG P
Sbjct: 1281 MGPQGRPGPPGHVGPPGPPGQPGPAGISAVGLKGDRGATGERGLAGLPGQPGPPGHPGPP 1340

Query: 277  GAIPGIGGIAG----------VGTPAAAAAAAAAAKAAKYG--AAAGLVPGGPGFGP--G 322
            G  PG  G AG           G P       AA +  + G    AG+ PGGPG     G
Sbjct: 1341 GE-PGTDGAAGKEGPPGKQGFYGPPGPKGDPGAAGQKGQAGEKGRAGM-PGGPGKSGSMG 1398

Query: 323  VVGVPG-AGVPG-VGVPG-AGIPVVPGAGIPGAA--------VPGVVSPEAAAKAAAKAA 371
             VG PG AG  G  G PG +G P +PG  +PG+         +   +  E       + A
Sbjct: 1399 PVGPPGPAGERGHPGAPGPSGSPGLPG--VPGSMGDMVNYDEIKRFIRQEIIKMFDERMA 1456

Query: 372  KYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEA 431
             Y +R        P     A G PG   G  G PG  G PG  G+PG  G  G    P  
Sbjct: 1457 YYTSRMQ-----FPMEMAAAPGRPG-PPGKDGAPGRPGAPGSPGLPGQIGREGRQGLPGV 1510

Query: 432  QAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG 489
            +     K  K  +  G+    G+   PG    PG G     G     G+ PG+   PG
Sbjct: 1511 RGLPGTKGEKGDIGIGIAGENGLPGPPGPQGPPGYGKMGATGPMGQQGI-PGIPGPPG 1567



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 138/445 (31%), Positives = 173/445 (38%), Gaps = 77/445 (17%)

Query: 23   PSRPGGVPGAIPG-GVPG--------GVFYPALGPGGKPLKPVPGGLAG-AGLGA--GLG 70
            P  P G PG +   G PG        G+  P+ G  G P  P P G+ G AGL    G  
Sbjct: 1163 PPGPPGFPGKVGSPGPPGPQAEKGSEGIRGPS-GLPGSPGPPGPPGIQGPAGLDGLDGKD 1221

Query: 71   AFPAVTF-PGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVKPG 129
              P +   PG   P G+      +K      GL G  G  G     G+   +PGA  +PG
Sbjct: 1222 GKPGLRGDPGPAGPPGLM-GPPGFKGKTGHPGLPGPKGDCGKPGPPGST-GRPGAEGEPG 1279

Query: 130  KVPGVGLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGG--------AFAGIPG 181
             +   G PG  PG V P    PG    PG P  AG+   A G+ G          AG+PG
Sbjct: 1280 AMGPQGRPGP-PGHVGP----PGP---PGQPGPAGIS--AVGLKGDRGATGERGLAGLPG 1329

Query: 182  V-GPFGGPQPGVPLGYPIKA-----PKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYP 235
              GP G P P    G    A     P   G YG P   G  P   G  G AG  G+AG P
Sbjct: 1330 QPGPPGHPGPPGEPGTDGAAGKEGPPGKQGFYGPPGPKGD-PGAAGQKGQAGEKGRAGMP 1388

Query: 236  TGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGA-GVPGVPGAIPGIGGIAGVGTPAAA 294
             G G             A + G   A   PG  G+ G+PGVPG++  +     +      
Sbjct: 1389 GGPGKSGSMGPVGPPGPAGERGHPGA---PGPSGSPGLPGVPGSMGDMVNYDEIKRFIRQ 1445

Query: 295  AAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA-GVPGVGVPGA-GIPVVPGA----- 347
                   +   Y  +    P      PG  G PG  G PG   PGA G P +PG      
Sbjct: 1446 EIIKMFDERMAYYTSRMQFPMEMAAAPGRPGPPGKDGAPGR--PGAPGSPGLPGQIGREG 1503

Query: 348  --GIPGA-AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGV----GAGGFPGFG-V 399
              G+PG   +PG                 G +  +G+G     G+    G  G PG+G +
Sbjct: 1504 RQGLPGVRGLPGTK---------------GEKGDIGIGIAGENGLPGPPGPQGPPGYGKM 1548

Query: 400  GVGGIPGVAGVPGVGGVPGVGGVPG 424
            G  G  G  G+PG+ G PG  G PG
Sbjct: 1549 GATGPMGQQGIPGIPGPPGPMGQPG 1573



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 61/200 (30%), Positives = 74/200 (37%), Gaps = 30/200 (15%)

Query: 466 VGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLG 525
           V LAP  G   G G   G+   PG   G   A      +++  A L+ A G   G  G  
Sbjct: 328 VTLAPS-GPKGGKGER-GLPGPPG-SKGEKGARGNDCVRISPDAPLQCAEG-PKGEKGES 383

Query: 526 VGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGI 585
             +G  GL    G  G     G  G   VPG     K  + G   PG +  +G  G  G 
Sbjct: 384 GALGPSGLPGSTGEKGQKGEKGDGGIKGVPG-----KPGRDGR--PGEICVIGPKGQKGD 436

Query: 586 PGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGL-GVGGLGVPGVGGLGGIPPAAAAK 644
           PG V   GP                GL G  G  GL G  G+G+PG  G  G PP     
Sbjct: 437 PGFV---GPE---------------GLAGEPGPPGLPGPPGIGLPGTPGDPGGPPGPKGD 478

Query: 645 AAKYGVAARPGFGLSPIFPG 664
               G+  + G G  P  PG
Sbjct: 479 KGSSGIPGKEGPGGKPGKPG 498


>gi|115392133 collagen, type XXIV, alpha 1 [Homo sapiens]
          Length = 1714

 Score =  138 bits (348), Expect = 1e-32
 Identities = 201/702 (28%), Positives = 254/702 (36%), Gaps = 117/702 (16%)

Query: 23   PSRPGGVPG--------AIPG-----GVPG--GVFYPALGPGGKPLKPVPGGLAGAGLGA 67
            P  P G+PG         IPG     G+PG  G   P   PG  P +PVPG     GL  
Sbjct: 499  PPGPAGIPGPSGKRGPRGIPGPHGNPGLPGLPGPKGPKGDPGFSPGQPVPGEKGDQGLSG 558

Query: 68   -----------GLGAFPAVT-FPGAL-VPGGVAD-AAAAYKAAKAGAGLGGVPGVGGLGV 113
                       GL   P +   PG   +PG   +  +  Y   +  AG  G PG  G   
Sbjct: 559  LMGPPGMQGDKGLKGHPGLPGLPGEQGIPGFAGNIGSPGYPGRQGLAGPEGNPGPKG--- 615

Query: 114  SAGAVVPQPGAGVKPGKVPGVGLPGV-----------YPGGVLPGARFP-GVGVLPGVPT 161
             A   +  PG   + G     G+PG+           +PG    G R P G+   PG+  
Sbjct: 616  -AQGFIGSPGEAGQLGPEGERGIPGIRGKKGFKGRQGFPGDF--GDRGPAGLDGSPGLVG 672

Query: 162  GAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLGYPIKAPKLPGGYGLPYTTGKLPYGYG 221
            G G  P  PG+ G+   +  +GP G P    P+G       L G  GLP   G      G
Sbjct: 673  GTG-PPGFPGLRGSVGPVGPIGPAGIPG---PMG-------LSGNKGLPGIKG----DKG 717

Query: 222  PGGVAGAAGKAGYPTGTG-VGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPG--A 278
              G AG  G+ GYP   G VG         K+      G  G+    G  G  G PG   
Sbjct: 718  EQGTAGELGEPGYPGDKGAVGLPGPPGMRGKSGPSGQTGDPGLQGPSGPPGPEGFPGDIG 777

Query: 279  IPGIGGIAGV-------GTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG-AG 330
            IPG  G  G        G P          +    GA   L P G     G  G PG  G
Sbjct: 778  IPGQNGPEGPKGLLGNRGPPGPPGLKGTQGEEGPIGAFGELGPRGKPGQKGYAGEPGPEG 837

Query: 331  VPG-VGVPG--AGIPVVPGAGIPG-AAVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPT 386
            + G VG  G    I      G+PG   + G +  +    +       G +  +G  G P 
Sbjct: 838  LKGEVGDQGNIGKIGETGPVGLPGEVGMTGSIGEKGERGSPGPLGPQGEKGVMGYPGPPG 897

Query: 387  Y--GVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPG-VGI-SPEAQAAAAAKAAKY 442
                +G  G PG  VG  G PG  G  G  G  G  G+ G  GI   + +     K   +
Sbjct: 898  VPGPIGPLGLPGH-VGARGPPGSQGPKGQRGSRGPDGLLGEQGIQGAKGEKGDQGKRGPH 956

Query: 443  GLVPGVG--VAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPG----IGPGGVA 496
            GL+   G     G    PG+   PG     G+   PG+    G    PG     GP G  
Sbjct: 957  GLIGKTGNPGERGFQGKPGLQGLPGSTGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTE 1016

Query: 497  AAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPG 556
              +    +  AK  +  A  +G        G G PGL    G PG     G  G   VPG
Sbjct: 1017 GESGLQGEPGAKGDVGTAGSVG--------GTGEPGLRGEPGAPGEEGLQGKDGLKGVPG 1068

Query: 557  --ALAAAKAAKYGAAVPGVLGGLGALGGVGIPG--GVVG----------------AGPAA 596
               L      K    +PG++G LG  G  G+PG  G+VG                 GP  
Sbjct: 1069 GRGLPGEDGEKGEMGLPGIIGPLGRSGQTGLPGPEGIVGIPGQRGRPGKKGDKGQIGPTG 1128

Query: 597  AAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGGIP 638
               +     K  + G  GA G  G  VG LG+ G  G  GIP
Sbjct: 1129 EVGSRGPPGKIGKSGPKGARGTRG-AVGHLGLMGPDGEPGIP 1169



 Score =  108 bits (269), Expect = 2e-23
 Identities = 218/801 (27%), Positives = 271/801 (33%), Gaps = 178/801 (22%)

Query: 22   HPSRPGGVPG--AIPG--GVPGGVFYPA----LGPGGKP-LKPVPGGLAGAGLGAGLGAF 72
            HP  PG +PG   IPG  G  G   YP      GP G P  K   G +   G    LG  
Sbjct: 574  HPGLPG-LPGEQGIPGFAGNIGSPGYPGRQGLAGPEGNPGPKGAQGFIGSPGEAGQLGPE 632

Query: 73   PAVTFPGAL----------VPGGVADAAAAYKAAKAG-AGLGGVPGVGGLGVSAGAVVPQ 121
                 PG             PG   D   A      G  G  G PG  GL  S G V P 
Sbjct: 633  GERGIPGIRGKKGFKGRQGFPGDFGDRGPAGLDGSPGLVGGTGPPGFPGLRGSVGPVGPI 692

Query: 122  PGAGVKPGKVP---GVGLPGVY-------PGGVLPGARFPGVGVLPGVPTGAGVKPKAPG 171
              AG+ PG +      GLPG+          G L    +PG     G+P   G++ K+  
Sbjct: 693  GPAGI-PGPMGLSGNKGLPGIKGDKGEQGTAGELGEPGYPGDKGAVGLPGPPGMRGKSGP 751

Query: 172  VGGAFAGIPGV-GPFGGPQP-------GVPLGYPIKAPK-------LPGGYGLPYTTGKL 216
             G    G PG+ GP G P P       G+P     + PK        PG  GL  T G+ 
Sbjct: 752  SGQT--GDPGLQGPSGPPGPEGFPGDIGIPGQNGPEGPKGLLGNRGPPGPPGLKGTQGEE 809

Query: 217  -PYG----YGPGGVAGAAGKAGYPTGTG-------------------VGPQAAAAAAAKA 252
             P G     GP G  G  G AG P   G                   VG           
Sbjct: 810  GPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGDQGNIGKIGETGPVGLPGEVGMTGSI 869

Query: 253  AAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAG-VGTPAAAAAAAAAAKAAKYGAAAG 311
              K   G+ G L   G  GV G PG  PG+ G  G +G P    A          G    
Sbjct: 870  GEKGERGSPGPLGPQGEKGVMGYPGP-PGVPGPIGPLGLPGHVGARGPPGSQGPKGQRGS 928

Query: 312  LVPGGPGFGPGVVGVPGA-------------------------GVPGV-GVPGA----GI 341
              P G     G+ G  G                          G PG+ G+PG+    G+
Sbjct: 929  RGPDGLLGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQGKPGLQGLPGSTGDRGL 988

Query: 342  PVVPGA-GIPGAAVP----GVVSPEAAAKAAAKAAKYGARPGVGVGGIPTYGVGAGGFPG 396
            P  PG  G+ G   P    G+  P      +    + GA+  VG  G     VG  G PG
Sbjct: 989  PGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGEPGAKGDVGTAG----SVGGTGEPG 1044

Query: 397  F----------GV----GVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKY 442
                       G+    G+ G+PG  G+PG  G  G  G+PG+ I P  ++         
Sbjct: 1045 LRGEPGAPGEEGLQGKDGLKGVPGGRGLPGEDGEKGEMGLPGI-IGPLGRSGQTGLPGPE 1103

Query: 443  GLV--PGVGVAPG-------VGVAPGVGVA--PG-VGLAPGVGVAPGVGVAPGVGVA--- 487
            G+V  PG    PG       +G    VG    PG +G +   G     G    +G+    
Sbjct: 1104 GIVGIPGQRGRPGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKGARGTRGAVGHLGLMGPD 1163

Query: 488  --PGI----------------GPGGVAAAAKSAAKVAAKAQLRAAAG-LG-------AGI 521
              PGI                GP G        + V      R   G +G        G 
Sbjct: 1164 GEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPGPRGEPGPVGDQGERGEPGA 1223

Query: 522  PGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAA-----KAAKYGAAVPGVLGG 576
             G    VGVPGL    G  G     G  G   + G   +      K A   +  PG+ G 
Sbjct: 1224 EGYKGHVGVPGLRGATGQQGPPGEPGDQGEQGLKGERGSEGNKGKKGAPGPSGKPGIPGL 1283

Query: 577  LGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLGVGGLGVPGVGGLGG 636
             G LG  GI G     G +          K    G+ G  G  GL  G  G PGV G  G
Sbjct: 1284 QGLLGPKGIQGYHGADGISGNPGKIGPPGKQGLPGIRGGPGRTGLA-GAPGPPGVKGSSG 1342

Query: 637  IP--PAAAAKAAKYGVAARPG 655
            +P  P       + G+  +PG
Sbjct: 1343 LPGSPGIQGPKGEQGLPGQPG 1363



 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 187/676 (27%), Positives = 234/676 (34%), Gaps = 140/676 (20%)

Query: 28   GVPGAI-PGGVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPAVTFPGALVPGGV 86
            G PG + P G  G + YP  GP G     VPG +   GL   +GA      PG+  P G 
Sbjct: 876  GSPGPLGPQGEKGVMGYP--GPPG-----VPGPIGPLGLPGHVGARGP---PGSQGPKGQ 925

Query: 87   ADAAA--------AYKAAKAGAGLGGVPGVGGLGVSAG-----AVVPQPGAGVKPGKVPG 133
              +            + AK   G  G  G  GL    G         +PG    PG    
Sbjct: 926  RGSRGPDGLLGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQGKPGLQGLPGSTGD 985

Query: 134  VGLPGVYPG--GVLPGARFPGVGVLPGVP-----TGAGVKPKAPGVGGAFAGIPGVGPFG 186
             GLPG  PG  G+      PG   + G P     +G   +P A G  G    + G G  G
Sbjct: 986  RGLPGE-PGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGEPGAKGDVGTAGSVGGTGEPG 1044

Query: 187  -GPQPGVPLGYPIKAPK----LPGGYGLPYTTGKL----------PYGY-------GPGG 224
               +PG P    ++       +PGG GLP   G+           P G        GP G
Sbjct: 1045 LRGEPGAPGEEGLQGKDGLKGVPGGRGLPGEDGEKGEMGLPGIIGPLGRSGQTGLPGPEG 1104

Query: 225  VAGAAGKAGYPTGTG----------VGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPG 274
            + G  G+ G P   G          VG +       K+  K   G  G +  +G  G  G
Sbjct: 1105 IVGIPGQRGRPGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKGARGTRGAVGHLGLMGPDG 1164

Query: 275  VPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPGA-GVPG 333
             PG IPG  G  G   P+         K      +  L P GP   PG VG  G  G PG
Sbjct: 1165 EPG-IPGYRGHQGQPGPSGLPGPKGE-KGYPGEDSTVLGPPGPRGEPGPVGDQGERGEPG 1222

Query: 334  V-GVPG-AGIPVVPGA----GIPGA-AVPGVVSPEAAAKAAAKAAKYGARPGVGVGGIPT 386
              G  G  G+P + GA    G PG     G    +    +     K GA    G  GIP 
Sbjct: 1223 AEGYKGHVGVPGLRGATGQQGPPGEPGDQGEQGLKGERGSEGNKGKKGAPGPSGKPGIPG 1282

Query: 387  YG--VGAGGFPGF--GVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAKY 442
                +G  G  G+    G+ G PG  G PG  G+PG+ G PG                  
Sbjct: 1283 LQGLLGPKGIQGYHGADGISGNPGKIGPPGKQGLPGIRGGPG------------------ 1324

Query: 443  GLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSA 502
                      G+  APG    PGV  + G+  +PG+    G    PG  PG         
Sbjct: 1325 --------RTGLAGAPG---PPGVKGSSGLPGSPGIQGPKGEQGLPG-QPG--------- 1363

Query: 503  AKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAK 562
              +  K   R A G            G PGL    G PG     G+ GF   PG     K
Sbjct: 1364 --IQGKRGHRGAQGDQG-------PCGDPGL---KGQPGEYGVQGLTGFQGFPG----PK 1407

Query: 563  AAKYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAGLGGLG 622
              +  A + G+ G  G +G  G        GP           +    G  G  G  G  
Sbjct: 1408 GPEGDAGIVGISGPKGPIGHRG------NTGPLGREGIIGPTGRTGPRGEKGFRGETG-P 1460

Query: 623  VGGLGVPGVGGLGGIP 638
             G  G PG  G  G P
Sbjct: 1461 QGPRGQPGPPGPPGAP 1476



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 123/477 (25%), Positives = 170/477 (35%), Gaps = 77/477 (16%)

Query: 215 KLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAKFGAGAAGVLPGVGGAGVPG 274
           ++ Y  GP G  G  G  G P G   GP                G  G+    G  G+PG
Sbjct: 483 EMEYLRGPKGDTGPPGPPG-PAGIP-GPSGKR------------GPRGIPGPHGNPGLPG 528

Query: 275 VPGAIPGIGGIAGVGTPAAAAAAAAAAKAAKYGAAAGLVPGGPGFGPGVVGVPG-AGVPG 333
           +PG           G P  +       +    G +  + P G     G+ G PG  G+PG
Sbjct: 529 LPGP------KGPKGDPGFSPGQPVPGEKGDQGLSGLMGPPGMQGDKGLKGHPGLPGLPG 582

Query: 334 -VGVPG----AGIPVVPG-------------------AGIPGAA----------VPGVVS 359
             G+PG     G P  PG                    G PG A          +PG+  
Sbjct: 583 EQGIPGFAGNIGSPGYPGRQGLAGPEGNPGPKGAQGFIGSPGEAGQLGPEGERGIPGIRG 642

Query: 360 PEAAAKAAAKAAKYGARPGVGVGGIP--TYGVGAGGFPGF--GVGVGGIPGVAGVPGVGG 415
            +           +G R   G+ G P    G G  GFPG    VG  G  G AG+PG  G
Sbjct: 643 KKGFKGRQGFPGDFGDRGPAGLDGSPGLVGGTGPPGFPGLRGSVGPVGPIGPAGIPGPMG 702

Query: 416 VPGVGGVPGVGISPEAQAAAAAKAAKYGLVPGVGVAPGVGVAPGVGVAPGVGLAPGVGVA 475
           + G  G+PG+    + +   A +  + G  PG   A G+   PG+    G     G    
Sbjct: 703 LSGNKGLPGIK-GDKGEQGTAGELGEPG-YPGDKGAVGLPGPPGMRGKSGPSGQTGDPGL 760

Query: 476 PGVGVAPGVGVAPGIGPGGVAAAAKSAAKVAAKAQLRAAAGLGAGIPGLGVGVGVPGLGV 535
            G    PG    P   PG +    ++  +   K  L        G PGL    G  G   
Sbjct: 761 QGPSGPPG----PEGFPGDIGIPGQNGPE-GPKGLLGNRG--PPGPPGLKGTQGEEGPIG 813

Query: 536 GAGVPGLGVGAGVPGFGAVPGALAAAKAAKYGAAVPGVLGGLGALGGVGIPG--GVVGA- 592
             G  G     G  G+   PG     +  K      G +G +G  G VG+PG  G+ G+ 
Sbjct: 814 AFGELGPRGKPGQKGYAGEPG----PEGLKGEVGDQGNIGKIGETGPVGLPGEVGMTGSI 869

Query: 593 GPAAAAAAAKAAAKAAQFGLVGAAGLGGL--GVGGLGVPGVGGLGGIPPAAAAKAAK 647
           G      +        + G++G  G  G+   +G LG+PG  G  G P +   K  +
Sbjct: 870 GEKGERGSPGPLGPQGEKGVMGYPGPPGVPGPIGPLGLPGHVGARGPPGSQGPKGQR 926



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 127/427 (29%), Positives = 158/427 (37%), Gaps = 53/427 (12%)

Query: 26   PGGVPGAIPG--GVPGGVFYPA-LGPGGKP-LKPVPGGLAGAGLGAGLGAFPAVTFPGAL 81
            P G+ G IPG  G PG       +GP G+   +  PG +  +G     G   AV   G +
Sbjct: 1102 PEGIVG-IPGQRGRPGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKGARGTRGAVGHLGLM 1160

Query: 82   VPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAG---AVVPQPGAGVKPGKVPGVGLPG 138
             P G       Y+  +   G  G+PG  G     G    V+  PG   +PG V   G  G
Sbjct: 1161 GPDG-EPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPGPRGEPGPVGDQGERG 1219

Query: 139  VYPGGVLPGAR-FPGVGVLPGV--PTGAGVKPKAPGVGGAFAGIPGVGPFGGPQPGVPLG 195
                   PGA  + G   +PG+   TG    P  PG  G   G+ G     G +      
Sbjct: 1220 E------PGAEGYKGHVGVPGLRGATGQQGPPGEPGDQGE-QGLKGERGSEGNKGKKGAP 1272

Query: 196  YPIKAPKLPGGYGLPYTTGKLPYGYGPGGVAGAAGKAGYPTGTGVGPQAAAAAAAKAAAK 255
             P   P +PG  GL    G   Y +G  G++G  GK G P     G Q            
Sbjct: 1273 GPSGKPGIPGLQGLLGPKGIQGY-HGADGISGNPGKIGPP-----GKQGLPGIRGGPGRT 1326

Query: 256  FGAGAAGVLPGV-GGAGVPGVPGAIPGIGGIAGV-GTPAAAAAAAAAAKAAKYGAAAGLV 313
              AGA G  PGV G +G+PG PG I G  G  G+ G P             K G      
Sbjct: 1327 GLAGAPGP-PGVKGSSGLPGSPG-IQGPKGEQGLPGQPGIQG---------KRGHRGAQG 1375

Query: 314  PGGPGFGPGVVGVPGA-GVPGVGVPGAGIPVVPGAGIP--GAAVPGVVSPEAAAKAAAKA 370
              GP   PG+ G PG  GV G+     G    PG   P   A + G+  P+         
Sbjct: 1376 DQGPCGDPGLKGQPGEYGVQGL----TGFQGFPGPKGPEGDAGIVGISGPKGPIGHRGNT 1431

Query: 371  AKYGARPGVGVGGIPTYGVGAGGFPGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPE 430
               G    +G    PT   G  G  GF     G  G  G  G  G PG  G PG     +
Sbjct: 1432 GPLGREGIIG----PTGRTGPRGEKGFR----GETGPQGPRGQPGPPGPPGAPGPRKQMD 1483

Query: 431  AQAAAAA 437
              AA  A
Sbjct: 1484 INAAIQA 1490



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 81/278 (29%), Positives = 99/278 (35%), Gaps = 25/278 (8%)

Query: 395 PGFGVGVGGIPGVAGVPGVGGVPGVGGVPGVGISPEAQAAAAAKAAK--YGLVPGVGV-- 450
           P    G  G PG AG+PG  G  G  G+PG   +P        K  K   G  PG  V  
Sbjct: 490 PKGDTGPPGPPGPAGIPGPSGKRGPRGIPGPHGNPGLPGLPGPKGPKGDPGFSPGQPVPG 549

Query: 451 ------APGVGVAPGVGVAPGVGLAPGVGVAPGVGVAPGVGVAPGIGPGGVAAAAKSAAK 504
                   G+   PG+    G+   PG+   PG    P  G A  IG  G       A  
Sbjct: 550 EKGDQGLSGLMGPPGMQGDKGLKGHPGLPGLPGEQGIP--GFAGNIGSPGYPGRQGLAGP 607

Query: 505 VAAKAQLRAAAGLGAGIPGLGVGVGVPGLGVGAGVPGLGVGAGVPGFGAVPGALAAAKAA 564
                   A   +G+  PG    +G  G     G+PG+    G  G    PG       A
Sbjct: 608 EGNPGPKGAQGFIGS--PGEAGQLGPEG---ERGIPGIRGKKGFKGRQGFPGDFGDRGPA 662

Query: 565 KYGAAVPGVLGGLGALGGVGIPGGVVGAGPAAAAAAAKAAAKAAQFGLVGAAG-LGGLGV 623
               + PG++GG G  G  G+ G V   GP   A        +   GL G  G  G  G 
Sbjct: 663 GLDGS-PGLVGGTGPPGFPGLRGSVGPVGPIGPAGIPGPMGLSGNKGLPGIKGDKGEQGT 721

Query: 624 GG-LGVPGVGGLGGI-----PPAAAAKAAKYGVAARPG 655
            G LG PG  G  G      PP    K+   G    PG
Sbjct: 722 AGELGEPGYPGDKGAVGLPGPPGMRGKSGPSGQTGDPG 759



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 90/327 (27%), Positives = 112/327 (34%), Gaps = 59/327 (18%)

Query: 19   SILHPSRPGGVPGAIPG----GVPGGVFYPALGPGGKPLKPVPGGLAGAGLGAGLGAFPA 74
            ++L P  P G PG +      G PG   Y   G  G P      GL GA    G    P 
Sbjct: 1198 TVLGPPGPRGEPGPVGDQGERGEPGAEGYK--GHVGVP------GLRGATGQQGPPGEPG 1249

Query: 75   VTFPGALVPGGVADAAAAYKAAKAGAGLGGVPGVGGLGVSAGAVVPQPGAGVK--PGKV- 131
                  L     ++     K A   +G  G+PG+ GL    G        G+   PGK+ 
Sbjct: 1250 DQGEQGLKGERGSEGNKGKKGAPGPSGKPGIPGLQGLLGPKGIQGYHGADGISGNPGKIG 1309

Query: 132  -PGV-GLPGVYPGGVLPGARFPGVGVLPGVPTGAGVKPKAPGVGGAFAGIPGVGPFGGP- 188
             PG  GLPG+  G   PG             TG    P  PGV G+ +G+PG     GP 
Sbjct: 1310 PPGKQGLPGIRGG---PGR------------TGLAGAPGPPGVKGS-SGLPGSPGIQGPK 1353

Query: 189  -QPGVPLGYPIKAPKLPGGYGLPYTTGKLPY--GYGPGGVAGAAGKAGYPTGTGVGPQAA 245
             + G+P              G P   GK  +    G  G  G  G  G P   GV  Q  
Sbjct: 1354 GEQGLP--------------GQPGIQGKRGHRGAQGDQGPCGDPGLKGQPGEYGV--QGL 1397

Query: 246  AAAAAKAAAKFGAGAAGVLPGVGGAGVPGVPGAIPGIGGIAGVGTPAAAAAAAAAAKAAK 305
                     K   G AG++      G+ G  G I   G    +G               +
Sbjct: 1398 TGFQGFPGPKGPEGDAGIV------GISGPKGPIGHRGNTGPLGREGIIGPTGRTGPRGE 1451

Query: 306  YGAAAGLVPGGPGFGPGVVGVPGAGVP 332
             G      P GP   PG  G PGA  P
Sbjct: 1452 KGFRGETGPQGPRGQPGPPGPPGAPGP 1478


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.144    0.444 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,856,911
Number of Sequences: 37866
Number of extensions: 2919824
Number of successful extensions: 57450
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 504
Number of HSP's successfully gapped in prelim test: 971
Number of HSP's that attempted gapping in prelim test: 13416
Number of HSP's gapped (non-prelim): 12517
length of query: 677
length of database: 18,247,518
effective HSP length: 109
effective length of query: 568
effective length of database: 14,120,124
effective search space: 8020230432
effective search space used: 8020230432
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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