Search of human proteins with 194018488

Search of human proteins with 194018488

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
         (980 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]          1941   0.0  
gi|6005942 valosin-containing protein [Homo sapiens]                  297   4e-80
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 290   6e-78
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 290   6e-78
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              271   2e-72
gi|4505725 peroxin1 [Homo sapiens]                                    258   3e-68
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       257   4e-68
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            184   4e-46
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]            172   2e-42
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            168   3e-41
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            167   3e-41
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     159   9e-39
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             159   1e-38
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           158   3e-38
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     157   4e-38
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   157   5e-38
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   157   5e-38
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   157   5e-38
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               155   2e-37
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               155   2e-37
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]              154   3e-37
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   153   7e-37
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                      146   1e-34
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                       146   1e-34
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]              145   2e-34
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]          135   2e-31
gi|40806170 spastin isoform 2 [Homo sapiens]                          135   2e-31
gi|11875211 spastin isoform 1 [Homo sapiens]                          135   2e-31
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]         132   2e-30
gi|31742536 fidgetin-like 1 [Homo sapiens]                            132   2e-30

>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score = 1941 bits (5029), Expect = 0.0
 Identities = 980/980 (100%), Positives = 980/980 (100%)

Query: 1   MALAVLRVLEPFPTETPPLAVLLPPGGPWPAAELGLVLALRPAGESPAGPALLVAALEGP 60
           MALAVLRVLEPFPTETPPLAVLLPPGGPWPAAELGLVLALRPAGESPAGPALLVAALEGP
Sbjct: 1   MALAVLRVLEPFPTETPPLAVLLPPGGPWPAAELGLVLALRPAGESPAGPALLVAALEGP 60

Query: 61  DAGTEEQGPGPPQLLVSRALLRLLALGSGAWVRARAVRRPPALGWALLGTSLGPGLGPRV 120
           DAGTEEQGPGPPQLLVSRALLRLLALGSGAWVRARAVRRPPALGWALLGTSLGPGLGPRV
Sbjct: 61  DAGTEEQGPGPPQLLVSRALLRLLALGSGAWVRARAVRRPPALGWALLGTSLGPGLGPRV 120

Query: 121 GPLLVRRGETLPVPGPRVLETRPALQGLLGPGTRLAVTELRGRARLCPESGDSSRPPPPP 180
           GPLLVRRGETLPVPGPRVLETRPALQGLLGPGTRLAVTELRGRARLCPESGDSSRPPPPP
Sbjct: 121 GPLLVRRGETLPVPGPRVLETRPALQGLLGPGTRLAVTELRGRARLCPESGDSSRPPPPP 180

Query: 181 VVSSFAVSGTVRRLQGVLGGTGDSLGVSRSCLRGLGLFQGEWVWVAQARESSNTSQPHLA 240
           VVSSFAVSGTVRRLQGVLGGTGDSLGVSRSCLRGLGLFQGEWVWVAQARESSNTSQPHLA
Sbjct: 181 VVSSFAVSGTVRRLQGVLGGTGDSLGVSRSCLRGLGLFQGEWVWVAQARESSNTSQPHLA 240

Query: 241 RVQVLEPRWDLSDRLGPGSGPLGEPLADGLALVPATLAFNLGCDPLEMGELRIQRYLEGS 300
           RVQVLEPRWDLSDRLGPGSGPLGEPLADGLALVPATLAFNLGCDPLEMGELRIQRYLEGS
Sbjct: 241 RVQVLEPRWDLSDRLGPGSGPLGEPLADGLALVPATLAFNLGCDPLEMGELRIQRYLEGS 300

Query: 301 IAPEDKGSCSLLPGPPFARELHIEIVSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVP 360
           IAPEDKGSCSLLPGPPFARELHIEIVSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVP
Sbjct: 301 IAPEDKGSCSLLPGPPFARELHIEIVSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVP 360

Query: 361 TIGQVEILEGSPEKLPRWREMFFKVKKTVGEAPDGPASAYLADTTHTSLYMVGSTLSPVP 420
           TIGQVEILEGSPEKLPRWREMFFKVKKTVGEAPDGPASAYLADTTHTSLYMVGSTLSPVP
Sbjct: 361 TIGQVEILEGSPEKLPRWREMFFKVKKTVGEAPDGPASAYLADTTHTSLYMVGSTLSPVP 420

Query: 421 WLPSEESTLWSSLSPPGLEALVSELCAVLKPRLQPGGALLTGTSSVLLRGPPGCGKTTVV 480
           WLPSEESTLWSSLSPPGLEALVSELCAVLKPRLQPGGALLTGTSSVLLRGPPGCGKTTVV
Sbjct: 421 WLPSEESTLWSSLSPPGLEALVSELCAVLKPRLQPGGALLTGTSSVLLRGPPGCGKTTVV 480

Query: 481 AAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDG 540
           AAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDG
Sbjct: 481 AAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDG 540

Query: 541 LGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQ 600
           LGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQ
Sbjct: 541 LGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQ 600

Query: 601 RLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLT 660
           RLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLT
Sbjct: 601 RLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLT 660

Query: 661 EEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILET 720
           EEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILET
Sbjct: 661 EEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILET 720

Query: 721 IQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQ 780
           IQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQ
Sbjct: 721 IQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQ 780

Query: 781 SEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQ 840
           SEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQ
Sbjct: 781 SEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQ 840

Query: 841 DVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVN 900
           DVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVN
Sbjct: 841 DVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVN 900

Query: 901 VLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLLQAAARLQP 960
           VLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLLQAAARLQP
Sbjct: 901 VLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLLQAAARLQP 960

Query: 961 SVSEQELLRYKRIQRKFAAC 980
           SVSEQELLRYKRIQRKFAAC
Sbjct: 961 SVSEQELLRYKRIQRKFAAC 980


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  297 bits (760), Expect = 4e-80
 Identities = 185/524 (35%), Positives = 290/524 (55%), Gaps = 26/524 (4%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           +LL GPPG GKT +  A  +  G     +    + ++ +G  E+ L+  F  A +  PA+
Sbjct: 241 ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI 300

Query: 526 LLLTAVDLLGRDRDGL-GEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQ 584
           + +  +D +   R+   GE  R   ++  LL   D L     ++V+A T+R   +   ++
Sbjct: 301 IFIDELDAIAPKREKTHGEVER--RIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALR 358

Query: 585 T--AFPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHS 642
               F  E+++       RL IL+  T ++ L  +V+L Q+A    G V  DL AL    
Sbjct: 359 RFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALC--- 415

Query: 643 SRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSV 702
           S AA   I+       L +E           +  +DF  AL Q   +  +     ++P V
Sbjct: 416 SEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRET-VVEVPQV 474

Query: 703 SWHDVGGLQEVKKEILETIQLPLEHPE-LLSLGLRRS-GLLLHGPPGTGKTLLAKAVATE 760
           +W D+GGL++VK+E+ E +Q P+EHP+  L  G+  S G+L +GPPG GKTLLAKA+A E
Sbjct: 475 TWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANE 534

Query: 761 CSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRS-GDSG 819
           C   F+S+KGPEL+ M+ G+SE NVRE+F +AR AAPC++FFDELDS+A +RG + GD G
Sbjct: 535 CQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGG 594

Query: 820 GVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQ 879
           G  DRV++Q+L E+DG+ + ++VF+IGATNRPD++DPA+LRPGR D+L+++    D  S+
Sbjct: 595 GAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPL-PDEKSR 653

Query: 880 LRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHD---LEEG 936
           + +L A  RK  +   V L   L       +GADL  +C  A   A++  +      E  
Sbjct: 654 VAILKANLRKSPVAKDVDL-EFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERE 712

Query: 937 LEPGSSALMLTMEDLL---------QAAARLQPSVSEQELLRYK 971
            +   SA+ +  +D +         +A    + SVS+ ++ +Y+
Sbjct: 713 RQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYE 756



 Score =  184 bits (466), Expect = 5e-46
 Identities = 110/278 (39%), Positives = 167/278 (60%), Gaps = 10/278 (3%)

Query: 702 VSWHDVGGLQEVKKEILETIQLPLEHPELL-SLGLRRS-GLLLHGPPGTGKTLLAKAVAT 759
           V + D+GG ++   +I E ++LPL HP L  ++G++   G+LL+GPPGTGKTL+A+AVA 
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260

Query: 760 ECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSG 819
           E    F  + GPE+++   G+SE N+R+ F  A   AP IIF DELD++AP R ++   G
Sbjct: 261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKT--HG 318

Query: 820 GVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQ 879
            V  R+VSQLL  +DGL     V V+ ATNRP+ +DPAL R GRFD+ V +G   D   +
Sbjct: 319 EVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGI-PDATGR 377

Query: 880 LRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVH--DLEEGL 937
           L +L   T+  KL   V L  V +     + GADL +LCS+A   A+++++   DLE+  
Sbjct: 378 LEILQIHTKNMKLADDVDLEQVANETHGHV-GADLAALCSEAALQAIRKKMDLIDLEDET 436

Query: 938 EPGS--SALMLTMEDLLQAAARLQPSVSEQELLRYKRI 973
                 ++L +TM+D   A ++  PS   + ++   ++
Sbjct: 437 IDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQV 474



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 51/191 (26%), Positives = 90/191 (47%), Gaps = 4/191 (2%)

Query: 460 LTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRAR 519
           +T +  VL  GPPGCGKT +  A  +    + + +    L     G  E  ++ IF +AR
Sbjct: 508 MTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKAR 567

Query: 520 RCRPAVLLLTAVDLLGRDRDGLGEDARVMA--VLRHLLLNEDPLNSCPPLMVVATTSRAQ 577
           +  P VL    +D + + R G   D    A  V+  +L   D +++   + ++  T+R  
Sbjct: 568 QAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPD 627

Query: 578 DL-PADVQTAFPHEL-EVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDL 635
            + PA ++     +L  +P   E  R++IL+A     P+ ++V+L  LA+   GF   DL
Sbjct: 628 IIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADL 687

Query: 636 YALLTHSSRAA 646
             +   + + A
Sbjct: 688 TEICQRACKLA 698


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  290 bits (741), Expect = 6e-78
 Identities = 201/566 (35%), Positives = 299/566 (52%), Gaps = 64/566 (11%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VLL GPPGCGKT +  A    L L +LKV    + +  SG  E KL+ +F +A    P +
Sbjct: 195 VLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCI 254

Query: 526 LLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPP---LMVVATTSRAQDLPAD 582
           + +  +D +   R+   +D     ++  LL   D LN+      ++V+  T+R   L   
Sbjct: 255 IFIDEIDAITPKREVASKDME-RRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPA 313

Query: 583 VQTA--FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLT 640
           ++ A  F  E+ +    E  R  IL+ L   L L Q  +   LA    GFV  DL AL  
Sbjct: 314 LRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCR 373

Query: 641 HSSRAACTRI---------KNSGL----AGGLTEEDEG---------------------- 665
            ++  A  R+         KN  +    + G+ EE  G                      
Sbjct: 374 EAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQD 433

Query: 666 ---ELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQ 722
              E    G  +   DF  AL  +Q + ++  G   +P+V+W D+G L+++++E+   I 
Sbjct: 434 PLSEEQMQGLCIELNDFIVALSSVQPS-AKREGFVTVPNVTWADIGALEDIREELTMAIL 492

Query: 723 LPLEHPELL-SLGL-RRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQ 780
            P+ +P+   +LGL   +G+LL GPPG GKTLLAKAVA E  L F+SVKGPEL+NMYVG+
Sbjct: 493 APVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGE 552

Query: 781 SEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQ 840
           SE  VR+VF RA+ +APC+IFFDE+D+L P   RS    G   RVV+QLL E+DGL + Q
Sbjct: 553 SERAVRQVFQRAKNSAPCVIFFDEVDALCPR--RSDRETGASVRVVNQLLTEMDGLEARQ 610

Query: 841 DVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVN 900
            VF++ ATNRPD++DPA+LRPGR DK +FVG     A +L +L  IT+     P  + VN
Sbjct: 611 QVFIMAATNRPDIIDPAILRPGRLDKTLFVGL-PPPADRLAILKTITKNGTKPPLDADVN 669

Query: 901 V--------LDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLL 952
           +         DC     TGADL +L  +A   AL++ +   + G E G   L ++ +   
Sbjct: 670 LEAIAGDLRCDC----YTGADLSALVREASICALRQEMARQKSGNEKGE--LKVSHKHFE 723

Query: 953 QAAARLQPSVSEQELLRYKRIQRKFA 978
           +A  +++ S+S+++ + Y+R+Q   +
Sbjct: 724 EAFKKVRSSISKKDQIMYERLQESLS 749



 Score =  167 bits (423), Expect = 4e-41
 Identities = 108/277 (38%), Positives = 161/277 (58%), Gaps = 10/277 (3%)

Query: 698 KIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLS-LGL-RRSGLLLHGPPGTGKTLLAK 755
           +I +V + DVGG     KE+ + + + + HPE+   LG+    G+LLHGPPG GKTLLA 
Sbjct: 152 QISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAH 210

Query: 756 AVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRS 815
           A+A E  L  L V  PE+++   G+SE+ +RE+F +A + APCIIF DE+D++ P R  +
Sbjct: 211 AIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVA 270

Query: 816 GDSGGVMDRVVSQLLAELDGLH---STQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGA 872
             S  +  R+V+QLL  +D L+   +T  V VIGATNRPD LDPAL R GRFD+ + +G 
Sbjct: 271 --SKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGI 328

Query: 873 NEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHD 932
             D AS+ R+L  + RK +L  +    + L    P   GADL +LC +A   A+ R +  
Sbjct: 329 -PDEASRERILQTLCRKLRLPQAFDFCH-LAHLTPGFVGADLMALCREAAMCAVNRVLMK 386

Query: 933 LEEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLR 969
           L+E  +       L  + + +     +P+   Q+ L+
Sbjct: 387 LQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQ 423



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 70/228 (30%), Positives = 102/228 (44%), Gaps = 14/228 (6%)

Query: 430 WSSLSPPGLEALVSELC-AVLKPRLQPGGALLTGT---SSVLLRGPPGCGKTTVVAAACS 485
           W+ +    LE +  EL  A+L P   P      G    + VLL GPPGCGKT +  A  +
Sbjct: 474 WADIG--ALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVAN 531

Query: 486 HLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA 545
             GL+ + V    L     G  E  ++ +F RA+   P V+    VD L   R      A
Sbjct: 532 ESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGA 591

Query: 546 RVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PADVQTA-FPHELEVPALSEGQRLS 603
            V  V+  LL   D L +   + ++A T+R   + PA ++       L V       RL+
Sbjct: 592 SV-RVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLA 650

Query: 604 ILRALTAH---LPLGQEVNLAQLA--RRCAGFVVGDLYALLTHSSRAA 646
           IL+ +T +    PL  +VNL  +A   RC  +   DL AL+  +S  A
Sbjct: 651 ILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICA 698


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  290 bits (741), Expect = 6e-78
 Identities = 201/566 (35%), Positives = 299/566 (52%), Gaps = 64/566 (11%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VLL GPPGCGKT +  A    L L +LKV    + +  SG  E KL+ +F +A    P +
Sbjct: 301 VLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCI 360

Query: 526 LLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPP---LMVVATTSRAQDLPAD 582
           + +  +D +   R+   +D     ++  LL   D LN+      ++V+  T+R   L   
Sbjct: 361 IFIDEIDAITPKREVASKDME-RRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPA 419

Query: 583 VQTA--FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLT 640
           ++ A  F  E+ +    E  R  IL+ L   L L Q  +   LA    GFV  DL AL  
Sbjct: 420 LRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCR 479

Query: 641 HSSRAACTRI---------KNSGL----AGGLTEEDEG---------------------- 665
            ++  A  R+         KN  +    + G+ EE  G                      
Sbjct: 480 EAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQD 539

Query: 666 ---ELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQ 722
              E    G  +   DF  AL  +Q + ++  G   +P+V+W D+G L+++++E+   I 
Sbjct: 540 PLSEEQMQGLCIELNDFIVALSSVQPS-AKREGFVTVPNVTWADIGALEDIREELTMAIL 598

Query: 723 LPLEHPELL-SLGL-RRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQ 780
            P+ +P+   +LGL   +G+LL GPPG GKTLLAKAVA E  L F+SVKGPEL+NMYVG+
Sbjct: 599 APVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGE 658

Query: 781 SEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQ 840
           SE  VR+VF RA+ +APC+IFFDE+D+L P   RS    G   RVV+QLL E+DGL + Q
Sbjct: 659 SERAVRQVFQRAKNSAPCVIFFDEVDALCPR--RSDRETGASVRVVNQLLTEMDGLEARQ 716

Query: 841 DVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVN 900
            VF++ ATNRPD++DPA+LRPGR DK +FVG     A +L +L  IT+     P  + VN
Sbjct: 717 QVFIMAATNRPDIIDPAILRPGRLDKTLFVGL-PPPADRLAILKTITKNGTKPPLDADVN 775

Query: 901 V--------LDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLL 952
           +         DC     TGADL +L  +A   AL++ +   + G E G   L ++ +   
Sbjct: 776 LEAIAGDLRCDC----YTGADLSALVREASICALRQEMARQKSGNEKGE--LKVSHKHFE 829

Query: 953 QAAARLQPSVSEQELLRYKRIQRKFA 978
           +A  +++ S+S+++ + Y+R+Q   +
Sbjct: 830 EAFKKVRSSISKKDQIMYERLQESLS 855



 Score =  167 bits (423), Expect = 4e-41
 Identities = 108/277 (38%), Positives = 161/277 (58%), Gaps = 10/277 (3%)

Query: 698 KIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLS-LGL-RRSGLLLHGPPGTGKTLLAK 755
           +I +V + DVGG     KE+ + + + + HPE+   LG+    G+LLHGPPG GKTLLA 
Sbjct: 258 QISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAH 316

Query: 756 AVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRS 815
           A+A E  L  L V  PE+++   G+SE+ +RE+F +A + APCIIF DE+D++ P R  +
Sbjct: 317 AIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVA 376

Query: 816 GDSGGVMDRVVSQLLAELDGLH---STQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGA 872
             S  +  R+V+QLL  +D L+   +T  V VIGATNRPD LDPAL R GRFD+ + +G 
Sbjct: 377 --SKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGI 434

Query: 873 NEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHD 932
             D AS+ R+L  + RK +L  +    + L    P   GADL +LC +A   A+ R +  
Sbjct: 435 -PDEASRERILQTLCRKLRLPQAFDFCH-LAHLTPGFVGADLMALCREAAMCAVNRVLMK 492

Query: 933 LEEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLR 969
           L+E  +       L  + + +     +P+   Q+ L+
Sbjct: 493 LQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQ 529



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 70/228 (30%), Positives = 102/228 (44%), Gaps = 14/228 (6%)

Query: 430 WSSLSPPGLEALVSELC-AVLKPRLQPGGALLTGT---SSVLLRGPPGCGKTTVVAAACS 485
           W+ +    LE +  EL  A+L P   P      G    + VLL GPPGCGKT +  A  +
Sbjct: 580 WADIG--ALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVAN 637

Query: 486 HLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA 545
             GL+ + V    L     G  E  ++ +F RA+   P V+    VD L   R      A
Sbjct: 638 ESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGA 697

Query: 546 RVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PADVQTA-FPHELEVPALSEGQRLS 603
            V  V+  LL   D L +   + ++A T+R   + PA ++       L V       RL+
Sbjct: 698 SV-RVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLA 756

Query: 604 ILRALTAH---LPLGQEVNLAQLA--RRCAGFVVGDLYALLTHSSRAA 646
           IL+ +T +    PL  +VNL  +A   RC  +   DL AL+  +S  A
Sbjct: 757 ILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICA 804


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  271 bits (694), Expect = 2e-72
 Identities = 177/519 (34%), Positives = 281/519 (54%), Gaps = 29/519 (5%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VLL GPPG GKT +  A  + +G ++  +    + ++  G  E KL+ IF+ A    P++
Sbjct: 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSI 449

Query: 526 LLLTAVDLLGRDRDGLGEDA--RVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADV 583
           + +  +D L   R+G   +   RV+A L  L+       S   ++V+  T+R   L A +
Sbjct: 450 IFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAAL 509

Query: 584 QTA--FPHELEVPALSEGQRLSILRALTAHLP-LGQEVNLAQLARRCAGFVVGDLYALLT 640
           +    F  E+E+   +   RL IL+ L   +P L  E  L QLA    G+V  DL  L  
Sbjct: 510 RRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCN 569

Query: 641 HSSRAACTRIKNSGLAGGLTEEDEGELCAAGF-PLLAEDFGQALEQLQTAHSQAVGAPKI 699
            +   A  RI          + +  ++  AG   +  +DF QA+  ++ +  + + A  +
Sbjct: 570 EAGLCALRRILKK-------QPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREI-AIDV 621

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPE-LLSLGLRR-SGLLLHGPPGTGKTLLAKAV 757
           P+VSW D+GGL+ +K ++ + ++ PL+HPE  + +G++   G+LL+GPPG  KT++AKA+
Sbjct: 622 PNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKAL 681

Query: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGD 817
           A E  L FL++KGPEL+N YVG+SE  VRE F +ARA AP IIFFDELD+LA  RG S  
Sbjct: 682 ANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLG 741

Query: 818 SGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRA 877
           +G V DRV++QLL E+DG+   +DV ++ ATNRPD +D AL+RPGR D++++V    D A
Sbjct: 742 AGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPL-PDAA 800

Query: 878 SQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGL 937
           ++  +         +   V L + L       +GA++ ++C +A   AL+  +       
Sbjct: 801 TRREIFKLQFHSMPVSNEVDL-DELILQTDAYSGAEIVAVCREAALLALEEDI------- 852

Query: 938 EPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRK 976
                A ++      QA + + P + E     Y+  Q K
Sbjct: 853 ----QANLIMKRHFTQALSTVTPRIPESLRRFYEDYQEK 887



 Score =  160 bits (404), Expect = 7e-39
 Identities = 108/272 (39%), Positives = 155/272 (56%), Gaps = 13/272 (4%)

Query: 702 VSWHDVGGLQEVKKEILETIQLPLEHPELL-SLGLRRS-GLLLHGPPGTGKTLLAKAVAT 759
           V++  +GGL    K I E I+LPL+ PEL  S G+    G+LL+GPPGTGKT++A+AVA 
Sbjct: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409

Query: 760 ECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSG 819
           E       + GPE+I+ + G++E  +R++FA A    P IIF DELD+L P   R G   
Sbjct: 410 EVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPK--REGAQN 467

Query: 820 GVMDRVVSQLLAELDGLH---STQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDR 876
            V  RVV+ LL  +DG+    S   V V+GATNRP  LD AL RPGRFDK + +G   + 
Sbjct: 468 EVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGV-PNA 526

Query: 877 ASQLRVLSAITRKF-KLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEE 935
             +L +L  + R+   L     L+ + +     + GADL  LC++A   AL RR+   + 
Sbjct: 527 QDRLDILQKLLRRVPHLLTEAELLQLANSAHGYV-GADLKVLCNEAGLCAL-RRILKKQP 584

Query: 936 GLEPGSSA--LMLTMEDLLQAAARLQPSVSEQ 965
            L     A  + +T++D LQA   ++PS   +
Sbjct: 585 NLPDVKVAGLVKITLKDFLQAMNDIRPSAMRE 616


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  258 bits (658), Expect = 3e-68
 Identities = 190/537 (35%), Positives = 287/537 (53%), Gaps = 46/537 (8%)

Query: 431  SSLSPPGLEALVSELCAVLKPRLQPGGALLTG--TSSVLLRGPPGCGKTTVVAAACSH-- 486
            +SL    LE +   L    +P  +   +L+ G    ++LL G  G GK+T+  A C    
Sbjct: 560  NSLGVSSLEHITHSLLG--RPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAF 617

Query: 487  --LGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGR----DRDG 540
              L  H+ +V C +L  +    ++  L+  FS A   +P+V+LL  +DL+          
Sbjct: 618  DKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHE 677

Query: 541  LGEDARVMAVLRHLL--LNEDPLNSCPPLMVVATTSRAQDL-PADVQTAFPHELE----V 593
               DA     L H L  + ++ ++    + ++AT+   Q L P  V     H  +    +
Sbjct: 678  HSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHI 737

Query: 594  PALSEGQRLSIL-----RALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACT 648
               ++ QR  IL       L   +    +++L  +A+   GFV  D   L+    RA  +
Sbjct: 738  QPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFVARDFTVLV---DRAIHS 794

Query: 649  RIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVG 708
            R+    ++   T E           L   DF +AL     A  ++V   K   + W  +G
Sbjct: 795  RLSRQSIS---TREK--------LVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIG 843

Query: 709  GLQEVKKEILETIQLPLEHPELLS-LGLR-RSGLLLHGPPGTGKTLLAKAVATECSLTFL 766
            GL EV++ +++TIQLP ++PEL + L +R R+G+LL+GPPGTGKTLLA  +A E  + F+
Sbjct: 844  GLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFI 903

Query: 767  SVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVV 826
            SVKGPEL++ Y+G SE+ VR++F RA+AA PCI+FFDE +S+AP RG   D+ GV DRVV
Sbjct: 904  SVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGH--DNTGVTDRVV 961

Query: 827  SQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAI 886
            +QLL +LDG+   Q V+V+ AT+RPDL+DPALLRPGR DK V+     D+ S+L +L+ +
Sbjct: 962  NQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYC-PPPDQVSRLEILNVL 1020

Query: 887  TRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSA 943
            +    L   V L +V        TGADL +L  +A   AL   +  L  GL+ GSS+
Sbjct: 1021 SDSLPLADDVDLQHVAS-VTDSFTGADLKALLYNAQLEALHGML--LSSGLQDGSSS 1074


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  257 bits (656), Expect = 4e-68
 Identities = 197/615 (32%), Positives = 311/615 (50%), Gaps = 78/615 (12%)

Query: 408 SLYMVGSTLSPVP-------------WLPSEESTLWSSLSPPGLEALVSELCAVLKPRLQ 454
           +L++VG T SP P               P  E+     +   GL      L  +L+  L+
Sbjct: 162 ALHIVGGTPSPDPAGLVTPRTRVSLGGEPPSEAQPQPEVPLGGLSEAADSLRELLRLPLR 221

Query: 455 PGGAL----LTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETK 510
              AL    L     VLL GPPG GKT +V A     G  LL V   +L     G  E  
Sbjct: 222 YPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGETEEN 281

Query: 511 LQAIFSRARRCR---PAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPL 567
           ++ +F RAR      P++L L  +D L   R     ++RV+A +  LL   D  +    +
Sbjct: 282 VRRVFQRARELASRGPSLLFLDEMDALCPQRGSRAPESRVVAQVLTLL---DGASGDREV 338

Query: 568 MVVATTSRAQDLPADVQTA--FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLAR 625
           +VV  T+R   L   ++    F  E+ +   +  QR  IL+ +T+ +P+   V+L  LA 
Sbjct: 339 VVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPISSHVDLGLLAE 398

Query: 626 RCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAE-DFGQALE 684
              G+V  DL AL   ++  A             +E+++        P++ E DF +A +
Sbjct: 399 MTVGYVGADLTALCREAAMHALLH----------SEKNQDN------PVIDEIDFLEAFK 442

Query: 685 QLQTAHSQAV-GAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHP-ELLSLGLRR-SGLL 741
            +Q +  ++V G   I  V W ++GGL++VK ++ ++I+ PL+ P E + +GL +  G+L
Sbjct: 443 NIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVL 502

Query: 742 LHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIF 801
           L+GPPG  KT L +A+AT C  +F+SV G +L + +VG SE+ + ++F +ARA+ P I+F
Sbjct: 503 LYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILF 562

Query: 802 FDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGL--------------HSTQDVF---- 843
            DE+DS+  +R  S     V +RV+S LL ELDG+                 Q+VF    
Sbjct: 563 LDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSV 622

Query: 844 -VIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNV- 901
            +I ATNRPD+LD ALLRPGR DK++++    D   +L +L   T+   + P VSL N+ 
Sbjct: 623 MIIAATNRPDVLDTALLRPGRLDKIIYI-PPPDHKGRLSILKVCTKTMPIGPDVSLENLA 681

Query: 902 LDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLLQAAARLQPS 961
            + C    +GADL +LC++A   AL+          E G  A  +  E  L++   ++PS
Sbjct: 682 AETC--FFSGADLRNLCTEAALLALQ----------ENGLDATTVKQEHFLKSLKTVKPS 729

Query: 962 VSEQELLRYKRIQRK 976
           +S ++L  Y+ + +K
Sbjct: 730 LSCKDLALYENLFKK 744


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  184 bits (467), Expect = 4e-46
 Identities = 109/253 (43%), Positives = 160/253 (63%), Gaps = 8/253 (3%)

Query: 698 KIPSVSWHDVGGLQEVKKEILETIQLPLEHPELL-SLGLRR-SGLLLHGPPGTGKTLLAK 755
           K+P  ++  +GGL +  KEI E I+LP++HPEL  +LG+ +  G+LL+GPPGTGKTLLA+
Sbjct: 142 KVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLAR 201

Query: 756 AVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRS 815
           AVA     TF+ V G EL+  ++G+    VRE+F  AR  AP IIF DE+DS+  SR   
Sbjct: 202 AVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEG 261

Query: 816 GDSG-GVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFD-KLVFVGAN 873
           G  G   + R + +LL +LDG  +T+++ VI ATNR D+LD ALLRPGR D K+ F   N
Sbjct: 262 GSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPN 321

Query: 874 EDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDA-MTAALKRRVHD 932
           E+  ++L +L   +RK  L   ++L  + +   P  +GA++  +C++A M A  +RRVH 
Sbjct: 322 EE--ARLDILKIHSRKMNLTRGINLRKIAELM-PGASGAEVKGVCTEAGMYALRERRVHV 378

Query: 933 LEEGLEPGSSALM 945
            +E  E   + +M
Sbjct: 379 TQEDFEMAVAKVM 391



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 48/185 (25%), Positives = 83/185 (44%), Gaps = 4/185 (2%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VLL GPPG GKT +  A   H     ++V  S L  +  G     ++ +F  AR   P++
Sbjct: 186 VLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSI 245

Query: 526 LLLTAVDLLGRDR--DGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADV 583
           + +  +D +G  R   G G D+ V   +  LL   D   +   + V+  T+R   L + +
Sbjct: 246 IFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSAL 305

Query: 584 --QTAFPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTH 641
                   ++E P  +E  RL IL+  +  + L + +NL ++A    G    ++  + T 
Sbjct: 306 LRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTE 365

Query: 642 SSRAA 646
           +   A
Sbjct: 366 AGMYA 370


>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
          Length = 797

 Score =  172 bits (435), Expect = 2e-42
 Identities = 95/232 (40%), Positives = 140/232 (60%), Gaps = 8/232 (3%)

Query: 702 VSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLR-RSGLLLHGPPGTGKTLLAKAVATE 760
           V + DV G +E K EI+E +       +   LG +   G +L GPPGTGKTLLAKA A E
Sbjct: 305 VKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGE 364

Query: 761 CSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGG 820
            ++ F++V G E + M+VG     VR++FA AR  APCI+F DE+D++   RGR G+ GG
Sbjct: 365 ANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGR-GNFGG 423

Query: 821 --VMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRAS 878
               +  ++QLL E+DG ++T +V ++  TNRPD+LDPALLRPGRFD+ +F+G   D   
Sbjct: 424 QSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGP-PDIKG 482

Query: 879 QLRVLSAITRKFKLEPSV---SLVNVLDCCPPQLTGADLYSLCSDAMTAALK 927
           +  +     R  KL+ ++    L   L    P  +GAD+ ++C++A   A +
Sbjct: 483 RASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAAR 534



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 48/183 (26%), Positives = 79/183 (43%), Gaps = 12/183 (6%)

Query: 455 PGGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAI 514
           P GA+LTG        PPG GKT +  A      +  + V  S       G    +++ +
Sbjct: 341 PKGAILTG--------PPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDL 392

Query: 515 FSRARRCRPAVLLLTAVDLLG--RDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVAT 572
           F+ AR+  P +L +  +D +G  R R   G  +     L  LL+  D  N+   ++++A 
Sbjct: 393 FALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAG 452

Query: 573 TSRAQDL-PADVQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGF 630
           T+R   L PA ++   F  ++ +       R SI +     L L   +   +LAR+ A  
Sbjct: 453 TNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLARKLASL 512

Query: 631 VVG 633
             G
Sbjct: 513 TPG 515


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  168 bits (425), Expect = 3e-41
 Identities = 103/258 (39%), Positives = 152/258 (58%), Gaps = 10/258 (3%)

Query: 683 LEQLQTAHSQAVGAPKI---PSVSWHDVGGLQEVKKEILETIQLPLEHPELL-SLGLRR- 737
           LE L T +   V A ++   P+  + D+GGL +  +E++E I LP+ H E   +LG++  
Sbjct: 161 LETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPP 220

Query: 738 SGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAP 797
            G+L++GPPGTGKTLLA+A A +   TFL + GP+L+ M++G   + VR+ FA A+  AP
Sbjct: 221 KGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAP 280

Query: 798 CIIFFDELDSLAPSRGRSGDSGG-VMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDP 856
            IIF DELD++   R  S  +G   + R + +LL +LDG      V VI ATNR D+LDP
Sbjct: 281 SIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDP 340

Query: 857 ALLRPGRFD-KLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLY 915
           ALLR GR D K+ F   NE+  ++ R++   +RK  + P V+    L  C     GA   
Sbjct: 341 ALLRSGRLDRKIEFPMPNEE--ARARIMQIHSRKMNVSPDVN-YEELARCTDDFNGAQCK 397

Query: 916 SLCSDAMTAALKRRVHDL 933
           ++C +A   AL+R   +L
Sbjct: 398 AVCVEAGMIALRRGATEL 415



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 42/164 (25%), Positives = 73/164 (44%), Gaps = 4/164 (2%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VL+ GPPG GKT +  A  +      LK+    L     G     ++  F+ A+   P++
Sbjct: 223 VLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSI 282

Query: 526 LLLTAVDLLGRDR--DGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PAD 582
           + +  +D +G  R       D  V   +  LL   D       + V+A T+R   L PA 
Sbjct: 283 IFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPAL 342

Query: 583 VQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLAR 625
           +++     ++E P  +E  R  I++  +  + +  +VN  +LAR
Sbjct: 343 LRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELAR 386


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  167 bits (424), Expect = 3e-41
 Identities = 98/235 (41%), Positives = 144/235 (61%), Gaps = 5/235 (2%)

Query: 698 KIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLS-LGLRR-SGLLLHGPPGTGKTLLAK 755
           K P  ++ D+GGL    +EI E+++LPL HPE    +G++   G++L+GPPGTGKTLLAK
Sbjct: 178 KAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAK 237

Query: 756 AVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRS 815
           AVA + S TFL V G ELI  Y+G   + VRE+F  A   AP I+F DE+D++   R  S
Sbjct: 238 AVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDS 297

Query: 816 GDSG-GVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANE 874
              G   + R + +LL +LDG  S  DV VI ATNR + LDPAL+RPGR D+ +     +
Sbjct: 298 NSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPD 357

Query: 875 DRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRR 929
           ++  + R+    T +  L   V+L +++      L+GAD+ ++C++A   AL+ R
Sbjct: 358 EKTKK-RIFQIHTSRMTLADDVTLDDLI-MAKDDLSGADIKAICTEAGLMALRER 410



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 45/185 (24%), Positives = 79/185 (42%), Gaps = 4/185 (2%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           V+L GPPG GKT +  A  +      L+V  S L  +  G     ++ +F  A    P++
Sbjct: 222 VILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSI 281

Query: 526 LLLTAVDLLGRDR--DGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PAD 582
           + +  +D +G  R     G +  +   +  LL   D  +S   + V+  T+R + L PA 
Sbjct: 282 VFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPAL 341

Query: 583 VQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTH 641
           ++      ++E P   E  +  I +  T+ + L  +V L  L          D+ A+ T 
Sbjct: 342 IRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTE 401

Query: 642 SSRAA 646
           +   A
Sbjct: 402 AGLMA 406


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  159 bits (403), Expect = 9e-39
 Identities = 106/294 (36%), Positives = 159/294 (54%), Gaps = 19/294 (6%)

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRR--SGLLLHGPPGTGKTLLAKAV 757
           P+V W D+  L E KK + E + LP+  PE    G+RR   G+L+ GPPGTGKTLLAKAV
Sbjct: 204 PNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFK-GIRRPWKGVLMVGPPGTGKTLLAKAV 262

Query: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGD 817
           ATEC  TF +V    L + Y G+SE+ VR +F  AR  +P  IF DE+DS+   RG S +
Sbjct: 263 ATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTS-E 321

Query: 818 SGGVMDRVVSQLLAELDGLHSTQD-------VFVIGATNRPDLLDPALLRPGRFDKLVFV 870
                 RV ++LL ++DG+  T +       V V+ ATN P  +D AL R  R +K +++
Sbjct: 322 EHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 379

Query: 871 GANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRV 930
                +  +  +L    R+ +L   V L ++ +      +GAD+ ++C DA   A++RR+
Sbjct: 380 PLPSAKGRE-ELLRISLRELELADDVDLASIAENM-EGYSGADITNVCRDASLMAMRRRI 437

Query: 931 HDLE----EGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC 980
             L       L      +  TMED   A  ++  SVS  ++ RY++   +F +C
Sbjct: 438 EGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC 491



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 66/239 (27%), Positives = 98/239 (41%), Gaps = 18/239 (7%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VL+ GPPG GKT +  A  +        V  S+L ++  G  E  ++ +F  AR   PA 
Sbjct: 245 VLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPAT 304

Query: 526 LLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPL-----NSCPPLMVVATTSRAQDLP 580
           + +  +D +   R    E      V   LL+  D +     N  P  MV+     A + P
Sbjct: 305 IFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLA--ATNFP 362

Query: 581 ADVQTAFPHELE----VPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLY 636
            D+  A    LE    +P  S   R  +LR     L L  +V+LA +A    G+   D+ 
Sbjct: 363 WDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADIT 422

Query: 637 ALLTHSSRAACTRIKNSGLAGGLTEEDEGELC--AAGFPLLAEDFGQALEQLQTAHSQA 693
            +   +S  A  R        GLT E+   L       P   EDF  AL+++  + S A
Sbjct: 423 NVCRDASLMAMRR-----RIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAA 476


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  159 bits (402), Expect = 1e-38
 Identities = 90/233 (38%), Positives = 135/233 (57%), Gaps = 5/233 (2%)

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPE-LLSLGLRR-SGLLLHGPPGTGKTLLAKAV 757
           P V++ DVGG +E  +++ E ++ PL HPE  ++LG+    G+LL GPPGTGKTL A+AV
Sbjct: 170 PDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAV 229

Query: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGD 817
           A      F+ V G EL+  YVG+    VRE+F  AR    C+IFFDE+D++  +R   G 
Sbjct: 230 ANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGA 289

Query: 818 SG-GVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDR 876
            G   + R + +L+ +LDG     ++ V+ ATNRPD LDPAL+RPGR D+ +      D 
Sbjct: 290 GGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSL-PDL 348

Query: 877 ASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRR 929
             +  +     R   +E  +    +   C P  TGA++ S+C++A   A++ R
Sbjct: 349 EGRTHIFKIHARSMSVERDIRFELLARLC-PNSTGAEIRSVCTEAGMFAIRAR 400



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 43/185 (23%), Positives = 76/185 (41%), Gaps = 4/185 (2%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VLL GPPG GKT    A  +      ++V  S L  +  G     ++ +F  AR  +  +
Sbjct: 212 VLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACL 271

Query: 526 LLLTAVDLLGRDR--DGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PAD 582
           +    +D +G  R  DG G D  V   +  L+   D  +    + V+  T+R   L PA 
Sbjct: 272 IFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPAL 331

Query: 583 VQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTH 641
           ++      ++E        R  I +     + + +++    LAR C      ++ ++ T 
Sbjct: 332 MRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTE 391

Query: 642 SSRAA 646
           +   A
Sbjct: 392 AGMFA 396


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  158 bits (399), Expect = 3e-38
 Identities = 103/280 (36%), Positives = 160/280 (57%), Gaps = 26/280 (9%)

Query: 701 SVSWHDVGGLQEVKKEILETIQLPLEHPELLS-LGL-RRSGLLLHGPPGTGKTLLAKAVA 758
           +VS+ ++GGL E  +E+ E I+LPL +PEL   +G+    G LL+GPPGTGKTLLA+AVA
Sbjct: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202

Query: 759 TECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDS 818
           ++    FL V    +++ Y+G+S   +RE+F  AR   PCIIF DE+D++   R   G S
Sbjct: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262

Query: 819 GG-VMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRA 877
               + R + +LL ++DG  +   V +I ATNRPD LDPALLRPGR D+ + +    ++A
Sbjct: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322

Query: 878 SQLRVL----SAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDL 933
            +L +L      IT+  +++   ++V + D       GADL ++C++A   A+ R  HD 
Sbjct: 323 -RLDILKIHAGPITKHGEIDYE-AIVKLSD----GFNGADLRNVCTEAGMFAI-RADHD- 374

Query: 934 EEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRI 973
                       +  ED ++A  ++  S   +  L YK +
Sbjct: 375 -----------FVVQEDFMKAVRKVADSKKLESKLDYKPV 403



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 39/370 (10%)

Query: 312 LPGPPFARELHIEIVSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVPTIGQVEILEGS 371
           +PG P+ R L I  ++ P      +Y   L  H +I   ++E          Q E  E  
Sbjct: 3   IPGIPYERRLLI--MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSEND 60

Query: 372 PEKLPRWREMFFKVKKTVGE------APDGPA----------SAYLADTTHTSLYMVGST 415
            + L    ++  +V K + E      A +GP            + L   T  +L M  +T
Sbjct: 61  LKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDM--TT 118

Query: 416 LSPVPWLPSEESTLWSSLSPP-----------GLEALVSELCAVLK-PRLQPGGALLTGT 463
           L+ + +LP E   L  ++S             GL   + EL  V++ P   P      G 
Sbjct: 119 LTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGI 178

Query: 464 ---SSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARR 520
                 LL GPPG GKT +  A  S L  + LKV  SS+  +  G     ++ +F+ AR 
Sbjct: 179 IPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARD 238

Query: 521 CRPAVLLLTAVDLLG--RDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQD 578
            +P ++ +  +D +G  R  +G   D  +   L  LL   D  ++   + ++  T+R   
Sbjct: 239 HQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDT 298

Query: 579 L-PADVQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLY 636
           L PA ++      ++ +   +E  RL IL+     +    E++   + +   GF   DL 
Sbjct: 299 LDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLR 358

Query: 637 ALLTHSSRAA 646
            + T +   A
Sbjct: 359 NVCTEAGMFA 368


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  157 bits (398), Expect = 4e-38
 Identities = 101/271 (37%), Positives = 154/271 (56%), Gaps = 13/271 (4%)

Query: 701 SVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAVA 758
           SV +  VGGL      + E +  PL +PE+      +   G L +GPPGTGKTL+A+A+A
Sbjct: 422 SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALA 481

Query: 759 TECS-----LTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRG 813
            ECS     + F   KG + ++ +VG+SE  +R +F +A    P IIFFDE+D LAP R 
Sbjct: 482 NECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRS 541

Query: 814 RSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGAN 873
              D   +   +VS LLA +DGL S  ++ VIGATNR D +DPAL RPGRFD+  F+ + 
Sbjct: 542 SRQDQ--IHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDR-EFLFSL 598

Query: 874 EDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRR---V 930
            D+ ++  +L   TR +  +P  + +  L        GAD+ S+C++A   AL+RR   +
Sbjct: 599 PDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQI 658

Query: 931 HDLEEGLEPGSSALMLTMEDLLQAAARLQPS 961
           +   E L+   S++ ++ +D   A  ++ P+
Sbjct: 659 YTTSEKLQLDLSSINISAKDFEVAMQKMIPA 689



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 64/271 (23%), Positives = 116/271 (42%), Gaps = 14/271 (5%)

Query: 467 LLRGPPGCGKTTVVAAACSHLGLHLLKVPC-----SSLCAESSGAVETKLQAIFSRARRC 521
           L  GPPG GKT V  A  +       +V       +   ++  G  E +L+ +F +A + 
Sbjct: 464 LFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQM 523

Query: 522 RPAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPA 581
           RP+++    +D L   R    +D    +++  LL   D L+S   ++V+  T+R   +  
Sbjct: 524 RPSIIFFDEIDGLAPVRSS-RQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDP 582

Query: 582 DVQT--AFPHELEVPALSEGQRLSILRALTAHL-PLGQEVNLAQLARRCAGFVVGDLYAL 638
            ++    F  E       +  R  IL+  T    P   +  L +LA  C G+   D+ ++
Sbjct: 583 ALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSI 642

Query: 639 LTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPK 698
              ++  A  R          T  ++ +L  +   + A+DF  A++++  A  +AV +P 
Sbjct: 643 CAEAALCALRR----RYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPG 698

Query: 699 IPSVSWHDVGGLQEVKKEILETIQLPLEHPE 729
             ++S      LQ    +ILE +Q    H E
Sbjct: 699 -QALSTVVKPLLQNTVDKILEALQRVFPHAE 728


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  157 bits (397), Expect = 5e-38
 Identities = 93/232 (40%), Positives = 140/232 (60%), Gaps = 7/232 (3%)

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLS-LGLRRS-GLLLHGPPGTGKTLLAKAV 757
           P V + D+GG+   K+E+ E ++LPL H EL   +G+    G+L++GPPG GKT+LAKAV
Sbjct: 156 PDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAV 215

Query: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSR--GRS 815
           A   +  F+ V G E +  Y+G+    VR+VF  A+  AP IIF DE+D++A  R   ++
Sbjct: 216 AHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQT 275

Query: 816 GDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANED 875
           G    V  R++ +LL ++DG     +V VI ATNR D LDPALLRPGR D+ +     + 
Sbjct: 276 GADREV-QRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDR 334

Query: 876 RASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALK 927
           R  +L + S IT K  L   V L + +   P +++GAD+ S+C ++   A++
Sbjct: 335 RQKRL-IFSTITSKMNLSEEVDLEDYV-ARPDKISGADINSICQESGMLAVR 384



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 48/185 (25%), Positives = 80/185 (43%), Gaps = 4/185 (2%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VL+ GPPGCGKT +  A   H     ++V  S    +  G     ++ +F  A+   PA+
Sbjct: 198 VLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAI 257

Query: 526 LLLTAVDLLGRDR--DGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PAD 582
           + +  +D +   R     G D  V  +L  LL   D  +    + V+  T+RA  L PA 
Sbjct: 258 IFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPAL 317

Query: 583 VQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTH 641
           ++      ++E P     Q+  I   +T+ + L +EV+L     R       D+ ++   
Sbjct: 318 LRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQE 377

Query: 642 SSRAA 646
           S   A
Sbjct: 378 SGMLA 382


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  157 bits (397), Expect = 5e-38
 Identities = 93/232 (40%), Positives = 140/232 (60%), Gaps = 7/232 (3%)

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLS-LGLRRS-GLLLHGPPGTGKTLLAKAV 757
           P V + D+GG+   K+E+ E ++LPL H EL   +G+    G+L++GPPG GKT+LAKAV
Sbjct: 129 PDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAV 188

Query: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSR--GRS 815
           A   +  F+ V G E +  Y+G+    VR+VF  A+  AP IIF DE+D++A  R   ++
Sbjct: 189 AHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQT 248

Query: 816 GDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANED 875
           G    V  R++ +LL ++DG     +V VI ATNR D LDPALLRPGR D+ +     + 
Sbjct: 249 GADREV-QRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDR 307

Query: 876 RASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALK 927
           R  +L + S IT K  L   V L + +   P +++GAD+ S+C ++   A++
Sbjct: 308 RQKRL-IFSTITSKMNLSEEVDLEDYV-ARPDKISGADINSICQESGMLAVR 357



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 48/185 (25%), Positives = 80/185 (43%), Gaps = 4/185 (2%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VL+ GPPGCGKT +  A   H     ++V  S    +  G     ++ +F  A+   PA+
Sbjct: 171 VLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAI 230

Query: 526 LLLTAVDLLGRDR--DGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PAD 582
           + +  +D +   R     G D  V  +L  LL   D  +    + V+  T+RA  L PA 
Sbjct: 231 IFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPAL 290

Query: 583 VQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTH 641
           ++      ++E P     Q+  I   +T+ + L +EV+L     R       D+ ++   
Sbjct: 291 LRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQE 350

Query: 642 SSRAA 646
           S   A
Sbjct: 351 SGMLA 355


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  157 bits (397), Expect = 5e-38
 Identities = 93/232 (40%), Positives = 140/232 (60%), Gaps = 7/232 (3%)

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLS-LGLRRS-GLLLHGPPGTGKTLLAKAV 757
           P V + D+GG+   K+E+ E ++LPL H EL   +G+    G+L++GPPG GKT+LAKAV
Sbjct: 160 PDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAV 219

Query: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSR--GRS 815
           A   +  F+ V G E +  Y+G+    VR+VF  A+  AP IIF DE+D++A  R   ++
Sbjct: 220 AHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQT 279

Query: 816 GDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANED 875
           G    V  R++ +LL ++DG     +V VI ATNR D LDPALLRPGR D+ +     + 
Sbjct: 280 GADREV-QRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDR 338

Query: 876 RASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALK 927
           R  +L + S IT K  L   V L + +   P +++GAD+ S+C ++   A++
Sbjct: 339 RQKRL-IFSTITSKMNLSEEVDLEDYV-ARPDKISGADINSICQESGMLAVR 388



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 48/185 (25%), Positives = 80/185 (43%), Gaps = 4/185 (2%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VL+ GPPGCGKT +  A   H     ++V  S    +  G     ++ +F  A+   PA+
Sbjct: 202 VLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAI 261

Query: 526 LLLTAVDLLGRDR--DGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PAD 582
           + +  +D +   R     G D  V  +L  LL   D  +    + V+  T+RA  L PA 
Sbjct: 262 IFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPAL 321

Query: 583 VQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTH 641
           ++      ++E P     Q+  I   +T+ + L +EV+L     R       D+ ++   
Sbjct: 322 LRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQE 381

Query: 642 SSRAA 646
           S   A
Sbjct: 382 SGMLA 386


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  155 bits (392), Expect = 2e-37
 Identities = 103/293 (35%), Positives = 160/293 (54%), Gaps = 19/293 (6%)

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRR--SGLLLHGPPGTGKTLLAKAV 757
           PS+ W D+  L+E KK + E + LP+  P+    G+RR   G+L+ GPPGTGKT+LAKAV
Sbjct: 203 PSIHWDDIADLEEAKKLLREAVVLPMWMPDFFK-GIRRPWKGVLMVGPPGTGKTMLAKAV 261

Query: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGD 817
           ATEC  TF +V    L + Y G+SE+ VR +F  AR  AP  IF DE+DS+   RG S D
Sbjct: 262 ATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTS-D 320

Query: 818 SGGVMDRVVSQLLAELDGLHSTQD-------VFVIGATNRPDLLDPALLRPGRFDKLVFV 870
                 RV S+LL ++DG+    +       V V+ ATN P  +D AL R  R +K +++
Sbjct: 321 EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 378

Query: 871 GANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRV 930
                +  +  +L    R+ +L+P + L ++ +      +GAD+ ++C DA   A++RR+
Sbjct: 379 PLPTAK-GRAELLKINLREVELDPDIQLEDIAEKI-EGYSGADITNVCRDASLMAMRRRI 436

Query: 931 HDLE----EGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAA 979
           + L       L      + +T  D   A  ++  SVS  +L +Y++   +F +
Sbjct: 437 NGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEFGS 489



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 60/239 (25%), Positives = 98/239 (41%), Gaps = 18/239 (7%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VL+ GPPG GKT +  A  +  G     V  S+L ++  G  E  ++ +F  AR   P  
Sbjct: 244 VLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTT 303

Query: 526 LLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPL-----NSCPPLMVVATTSRAQDLP 580
           + +  +D +   R    E      V   LL+  D +     N  P  MV+     A + P
Sbjct: 304 IFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLA--ATNFP 361

Query: 581 ADVQTAFPHELE----VPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLY 636
            D+  A    LE    +P  +   R  +L+     + L  ++ L  +A +  G+   D+ 
Sbjct: 362 WDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADIT 421

Query: 637 ALLTHSSRAACTRIKNSGLAGGLTEEDEGELC--AAGFPLLAEDFGQALEQLQTAHSQA 693
            +   +S  A  R  N     GL+ E+   L       P+   DF  AL+++  + S A
Sbjct: 422 NVCRDASLMAMRRRIN-----GLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAA 475


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  155 bits (392), Expect = 2e-37
 Identities = 103/293 (35%), Positives = 160/293 (54%), Gaps = 19/293 (6%)

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRR--SGLLLHGPPGTGKTLLAKAV 757
           PS+ W D+  L+E KK + E + LP+  P+    G+RR   G+L+ GPPGTGKT+LAKAV
Sbjct: 203 PSIHWDDIADLEEAKKLLREAVVLPMWMPDFFK-GIRRPWKGVLMVGPPGTGKTMLAKAV 261

Query: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGD 817
           ATEC  TF +V    L + Y G+SE+ VR +F  AR  AP  IF DE+DS+   RG S D
Sbjct: 262 ATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTS-D 320

Query: 818 SGGVMDRVVSQLLAELDGLHSTQD-------VFVIGATNRPDLLDPALLRPGRFDKLVFV 870
                 RV S+LL ++DG+    +       V V+ ATN P  +D AL R  R +K +++
Sbjct: 321 EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 378

Query: 871 GANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRV 930
                +  +  +L    R+ +L+P + L ++ +      +GAD+ ++C DA   A++RR+
Sbjct: 379 PLPTAK-GRAELLKINLREVELDPDIQLEDIAEKI-EGYSGADITNVCRDASLMAMRRRI 436

Query: 931 HDLE----EGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAA 979
           + L       L      + +T  D   A  ++  SVS  +L +Y++   +F +
Sbjct: 437 NGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEFGS 489



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 60/239 (25%), Positives = 98/239 (41%), Gaps = 18/239 (7%)

Query: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
           VL+ GPPG GKT +  A  +  G     V  S+L ++  G  E  ++ +F  AR   P  
Sbjct: 244 VLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTT 303

Query: 526 LLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPL-----NSCPPLMVVATTSRAQDLP 580
           + +  +D +   R    E      V   LL+  D +     N  P  MV+     A + P
Sbjct: 304 IFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLA--ATNFP 361

Query: 581 ADVQTAFPHELE----VPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLY 636
            D+  A    LE    +P  +   R  +L+     + L  ++ L  +A +  G+   D+ 
Sbjct: 362 WDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADIT 421

Query: 637 ALLTHSSRAACTRIKNSGLAGGLTEEDEGELC--AAGFPLLAEDFGQALEQLQTAHSQA 693
            +   +S  A  R  N     GL+ E+   L       P+   DF  AL+++  + S A
Sbjct: 422 NVCRDASLMAMRRRIN-----GLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAA 475


>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
          Length = 795

 Score =  154 bits (390), Expect = 3e-37
 Identities = 94/250 (37%), Positives = 136/250 (54%), Gaps = 5/250 (2%)

Query: 682 ALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLR-RSGL 740
           A  QL+ A    V       VS+ DV G+ E K E+ E +         L LG +   G 
Sbjct: 286 AFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGA 345

Query: 741 LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCII 800
           LL GPPG GKTLLAKAVATE  + FL++ GPE + +  G     VR +F  ARA APCI+
Sbjct: 346 LLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIV 405

Query: 801 FFDELDSLAPSRG--RSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPAL 858
           + DE+D++   R    SG S    ++ ++QLL E+DG+ +T  V V+ +TNR D+LD AL
Sbjct: 406 YIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGAL 465

Query: 859 LRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNV-LDCCPPQLTGADLYSL 917
           +RPGR D+ VF+        +  +     +  KL  S +  +  L    P  +GAD+ ++
Sbjct: 466 MRPGRLDRHVFIDL-PTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANI 524

Query: 918 CSDAMTAALK 927
           C++A   A +
Sbjct: 525 CNEAALHAAR 534



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 3/116 (2%)

Query: 467 LLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVL 526
           LL GPPGCGKT +  A  +   +  L +          G    +++++F  AR   P ++
Sbjct: 346 LLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIV 405

Query: 527 LLTAVDLLGRDRDGL---GEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL 579
            +  +D +G+ R        +      L  LL+  D + +   ++V+A+T+RA  L
Sbjct: 406 YIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADIL 461


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  153 bits (387), Expect = 7e-37
 Identities = 99/271 (36%), Positives = 152/271 (56%), Gaps = 13/271 (4%)

Query: 701 SVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAVA 758
           SV +  +GGL      + E +  PL +PE+      +   G L +GPPGTGKTL+A+A+A
Sbjct: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455

Query: 759 TECS-----LTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRG 813
            ECS     + F   KG + ++ +VG+SE  +R +F +A    P IIFFDE+D LAP R 
Sbjct: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515

Query: 814 RSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGAN 873
              D   +   +VS LLA +DGL +  ++ VIGATNR D +DPAL RPGRFD+  F+   
Sbjct: 516 SRQDQ--IHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDR-EFLFNL 572

Query: 874 EDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRR---V 930
            D+ ++  +L   TR +  + S + +  L        GAD+ +LC++A   AL+RR   +
Sbjct: 573 PDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQI 632

Query: 931 HDLEEGLEPGSSALMLTMEDLLQAAARLQPS 961
           +     L+   S+++L+ +D   A   + P+
Sbjct: 633 YASSHKLQLDVSSIVLSAQDFYHAMQNIVPA 663



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 58/236 (24%), Positives = 100/236 (42%), Gaps = 13/236 (5%)

Query: 467 LLRGPPGCGKTTVVAAACSHLGLHLLKVPC-----SSLCAESSGAVETKLQAIFSRARRC 521
           L  GPPG GKT V  A  +       KV       +   ++  G  E +L+ +F +A   
Sbjct: 438 LFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLM 497

Query: 522 RPAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPA 581
           RP+++    +D L   R    +D    +++  LL   D L++   ++V+  T+R   +  
Sbjct: 498 RPSIIFFDEIDGLAPVRSS-RQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDP 556

Query: 582 DVQT--AFPHELEVPALSEGQRLSILRALTAHL-PLGQEVNLAQLARRCAGFVVGDLYAL 638
            ++    F  E       +  R  IL+  T    P   +  L +LA +C G+   D+ AL
Sbjct: 557 ALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKAL 616

Query: 639 LTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAV 694
            T ++  A  R      A       + +L  +   L A+DF  A++ +  A  +AV
Sbjct: 617 CTEAALIALRRRYPQIYA----SSHKLQLDVSSIVLSAQDFYHAMQNIVPASQRAV 668


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score =  146 bits (368), Expect = 1e-34
 Identities = 102/282 (36%), Positives = 149/282 (52%), Gaps = 19/282 (6%)

Query: 672 FPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELL 731
           + LL   F     +  T    AV   ++ +V++  V G++E K+E+ E ++  L++P+  
Sbjct: 306 YGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKF 364

Query: 732 SL--GLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVF 789
           ++  G    G+LL GPPGTGKTLLA+AVA E  + F    G E   M+VG     +R +F
Sbjct: 365 TILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLF 424

Query: 790 ARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATN 849
             A+A APC+IF DELDS+   R  S        + ++QLLAE+DG    + V +IGATN
Sbjct: 425 REAKANAPCVIFIDELDSVGGKRIES-PMHPYSRQTINQLLAEMDGFKPNEGVIIIGATN 483

Query: 850 RPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQL 909
            P+ LD AL+RPGRFD  V V    D   +  +L     K K + SV    ++       
Sbjct: 484 FPEALDNALIRPGRFDMQVTV-PRPDVKGRTEILKWYLNKIKFDQSVD-PEIIARGTVGF 541

Query: 910 TGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDL 951
           +GA+L +L +    AALK  V   E          M+TM++L
Sbjct: 542 SGAELENLVNQ---AALKAAVDGKE----------MVTMKEL 570



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 50/218 (22%), Positives = 82/218 (37%), Gaps = 11/218 (5%)

Query: 437 GLEALVSELCAVLKPRLQP------GGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLH 490
           G+E    EL  V++    P      GG L  G   +LL GPPG GKT +  A      + 
Sbjct: 343 GVEEAKQELQEVVEFLKNPQKFTILGGKLPKG---ILLVGPPGTGKTLLARAVAGEADVP 399

Query: 491 LLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVMAV 550
                 S       G   ++++ +F  A+   P V+ +  +D +G  R            
Sbjct: 400 FYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQT 459

Query: 551 LRHLLLNEDPLNSCPPLMVVATTS--RAQDLPADVQTAFPHELEVPALSEGQRLSILRAL 608
           +  LL   D       ++++  T+   A D        F  ++ VP      R  IL+  
Sbjct: 460 INQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWY 519

Query: 609 TAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAA 646
              +   Q V+   +AR   GF   +L  L+  ++  A
Sbjct: 520 LNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKA 557


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score =  146 bits (368), Expect = 1e-34
 Identities = 102/282 (36%), Positives = 149/282 (52%), Gaps = 19/282 (6%)

Query: 672 FPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELL 731
           + LL   F     +  T    AV   ++ +V++  V G++E K+E+ E ++  L++P+  
Sbjct: 249 YGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKF 307

Query: 732 SL--GLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVF 789
           ++  G    G+LL GPPGTGKTLLA+AVA E  + F    G E   M+VG     +R +F
Sbjct: 308 TILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLF 367

Query: 790 ARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATN 849
             A+A APC+IF DELDS+   R  S        + ++QLLAE+DG    + V +IGATN
Sbjct: 368 REAKANAPCVIFIDELDSVGGKRIES-PMHPYSRQTINQLLAEMDGFKPNEGVIIIGATN 426

Query: 850 RPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQL 909
            P+ LD AL+RPGRFD  V V    D   +  +L     K K + SV    ++       
Sbjct: 427 FPEALDNALIRPGRFDMQVTV-PRPDVKGRTEILKWYLNKIKFDQSVD-PEIIARGTVGF 484

Query: 910 TGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDL 951
           +GA+L +L +    AALK  V   E          M+TM++L
Sbjct: 485 SGAELENLVNQ---AALKAAVDGKE----------MVTMKEL 513



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 50/218 (22%), Positives = 82/218 (37%), Gaps = 11/218 (5%)

Query: 437 GLEALVSELCAVLKPRLQP------GGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLH 490
           G+E    EL  V++    P      GG L  G   +LL GPPG GKT +  A      + 
Sbjct: 286 GVEEAKQELQEVVEFLKNPQKFTILGGKLPKG---ILLVGPPGTGKTLLARAVAGEADVP 342

Query: 491 LLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVMAV 550
                 S       G   ++++ +F  A+   P V+ +  +D +G  R            
Sbjct: 343 FYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQT 402

Query: 551 LRHLLLNEDPLNSCPPLMVVATTS--RAQDLPADVQTAFPHELEVPALSEGQRLSILRAL 608
           +  LL   D       ++++  T+   A D        F  ++ VP      R  IL+  
Sbjct: 403 INQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWY 462

Query: 609 TAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAA 646
              +   Q V+   +AR   GF   +L  L+  ++  A
Sbjct: 463 LNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKA 500


>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score =  145 bits (365), Expect = 2e-34
 Identities = 105/293 (35%), Positives = 161/293 (54%), Gaps = 21/293 (7%)

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRR-SGLLLHGPPGTGKTLLAKAVA 758
           P++ W+D+ GL   K+ + E +  P+ +P+L +  L    GLLL+GPPGTGKTLLAKAVA
Sbjct: 177 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVA 236

Query: 759 TECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDS 818
           TEC  TF ++    +++ + G SE+ VR +F  AR  AP  IF DEL+S+   RG +  S
Sbjct: 237 TECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTA--S 294

Query: 819 GGVMD---RVVSQLLAELDGLHSTQD-VFVIGATNRPDLLDPALLRPGRFDKLVFVGANE 874
           GG  +   R+ ++LL ++DGL  ++D VFV+ A+N P  LD A+LR  R +K + V    
Sbjct: 295 GGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPS 352

Query: 875 DRASQLRV---LSAITRKFKLEPSVSL-VNVLDCCPPQLTGADLYSLCSDAMTAALKRRV 930
             A Q  +   L  +++   LE    L  +VL       +G+D+  +C +A    + R++
Sbjct: 353 REARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPV-RKI 411

Query: 931 HDLEEGLEPGSSAL------MLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977
            D  E  +  SS L      ++T  D L      +PS ++    RY   QR+F
Sbjct: 412 FDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPS-AKNLAQRYSDWQREF 463



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 46/197 (23%), Positives = 81/197 (41%), Gaps = 17/197 (8%)

Query: 451 PRLQPGGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETK 510
           P+L  G  +L+    +LL GPPG GKT +  A  +        +  S++ ++  G  E  
Sbjct: 205 PQLFTG--ILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKL 262

Query: 511 LQAIFSRARRCRPAVLLLTAVDLLGRDRDGL--GEDARVMAVLRHLLLNEDPLNSCPPLM 568
           ++ +F  AR   P+ + L  ++ +   R     GE    + +   LL+  D L     L+
Sbjct: 263 VRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLV 322

Query: 569 VVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAH----------LPLGQEV 618
            V     A +LP ++  A    LE   L +       +A+  H          L L  E+
Sbjct: 323 FVLA---ASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTEL 379

Query: 619 NLAQLARRCAGFVVGDL 635
             + L++   G+   D+
Sbjct: 380 EYSVLSQETEGYSGSDI 396


>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
          Length = 437

 Score =  135 bits (340), Expect = 2e-31
 Identities = 103/322 (31%), Positives = 162/322 (50%), Gaps = 54/322 (16%)

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAV 757
           P++ W+DV GL+  K+ + E + LP++ P L + G R    G+LL GPPGTGK+ LAKAV
Sbjct: 122 PNIRWNDVAGLEGAKEALKEAVILPIKFPHLFT-GKRTPWRGILLFGPPGTGKSYLAKAV 180

Query: 758 ATECS-LTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSG 816
           ATE +  TF SV   +L++ ++G+SE+ V+ +F  AR   P IIF DE+DSL  SR  + 
Sbjct: 181 ATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENE 240

Query: 817 DSGGVMDRVVSQLLAELDGLHSTQD-VFVIGATNRPDLLDPALLRPGRFDKLVFVGANED 875
                  R+ ++ L ++ G+ +  D   V+GATN P +LD A+ R  RF+K +++   E+
Sbjct: 241 SEAA--RRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEE 296

Query: 876 --RASQLRV----------------------------LSAITRKFKLEP---SVSLVNVL 902
             RA   R+                            +S I R   ++P     S  +  
Sbjct: 297 AARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFK 356

Query: 903 DCCPPQLTGA-----DLYSLCSDAMTAALKRRVHDLEEGLEPGSSAL--MLTMEDLLQAA 955
             C P  T       DL + CS     A++    D+     PG   L  ++ M D+L++ 
Sbjct: 357 KVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDV-----PGDKLLEPVVCMSDMLRSL 411

Query: 956 ARLQPSVSEQELLRYKRIQRKF 977
           A  +P+V+  +LL+ K+    F
Sbjct: 412 ATTRPTVNADDLLKVKKFSEDF 433



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 41/190 (21%), Positives = 83/190 (43%), Gaps = 2/190 (1%)

Query: 466 VLLRGPPGCGKTTVVAAACSHL-GLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPA 524
           +LL GPPG GK+ +  A  +         V  S L ++  G  E  ++ +F  AR+ +P+
Sbjct: 163 ILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPS 222

Query: 525 VLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQ 584
           ++ +  VD L   R+    +A        L+  +   N+    +V+  T+    L + ++
Sbjct: 223 IIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIR 282

Query: 585 TAFPHELEVPALSEGQRLSILRALTAHLPLG-QEVNLAQLARRCAGFVVGDLYALLTHSS 643
             F   + +P   E  R  + R      P    + N+ +LAR+  G+   D+  ++  S 
Sbjct: 283 RRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSL 342

Query: 644 RAACTRIKNS 653
                +++++
Sbjct: 343 MQPVRKVQSA 352


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  135 bits (339), Expect = 2e-31
 Identities = 100/281 (35%), Positives = 146/281 (51%), Gaps = 11/281 (3%)

Query: 701 SVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAVA 758
           +V + D+ G    K+ + E + LP   PEL + GLR    GLLL GPPG GKT+LAKAVA
Sbjct: 306 AVKFDDIAGQDLAKQALQEIVILPSLRPELFT-GLRAPARGLLLFGPPGNGKTMLAKAVA 364

Query: 759 TECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDS 818
            E + TF ++    L + YVG+ E+ VR +FA AR   P IIF DE+DSL   R R G+ 
Sbjct: 365 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCER-REGEH 423

Query: 819 GGVMDRVVSQLLAELDGLHSTQD--VFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDR 876
                R+ ++ L E DG+ S  D  V V+GATNRP  LD A+LR  RF K V+V    + 
Sbjct: 424 -DASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEE 480

Query: 877 ASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEG 936
              L + + + ++        L   L       +G+DL +L  DA    ++    +  + 
Sbjct: 481 TRLLLLKNLLCKQGSPLTQKELAQ-LARMTDGYSGSDLTALAKDAALGPIRELKPEQVKN 539

Query: 937 LEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977
           +   S    + + D  ++  +++ SVS Q L  Y R  + F
Sbjct: 540 MS-ASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDF 579



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 64/213 (30%), Positives = 103/213 (48%), Gaps = 14/213 (6%)

Query: 448 VLKPRLQPGGALLTGTSS----VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAES 503
           V+ P L+P   L TG  +    +LL GPPG GKT +  A  +        +  +SL ++ 
Sbjct: 326 VILPSLRP--ELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKY 383

Query: 504 SGAVETKLQAIFSRARRCRPAVLLLTAVD-LLGRDRDGLGEDARVMAVLRHLLLNEDPLN 562
            G  E  ++A+F+ AR  +P+++ +  VD LL   R+G  + +R +      L+  D + 
Sbjct: 384 VGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKT--EFLIEFDGVQ 441

Query: 563 SC--PPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAH--LPLGQEV 618
           S     ++V+  T+R Q+L   V   F   + V   +E  RL +L+ L      PL Q+ 
Sbjct: 442 SAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK- 500

Query: 619 NLAQLARRCAGFVVGDLYALLTHSSRAACTRIK 651
            LAQLAR   G+   DL AL   ++      +K
Sbjct: 501 ELAQLARMTDGYSGSDLTALAKDAALGPIRELK 533


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score =  135 bits (339), Expect = 2e-31
 Identities = 100/281 (35%), Positives = 146/281 (51%), Gaps = 11/281 (3%)

Query: 701 SVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAVA 758
           +V + D+ G    K+ + E + LP   PEL + GLR    GLLL GPPG GKT+LAKAVA
Sbjct: 338 AVKFDDIAGQDLAKQALQEIVILPSLRPELFT-GLRAPARGLLLFGPPGNGKTMLAKAVA 396

Query: 759 TECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDS 818
            E + TF ++    L + YVG+ E+ VR +FA AR   P IIF DE+DSL   R R G+ 
Sbjct: 397 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCER-REGEH 455

Query: 819 GGVMDRVVSQLLAELDGLHSTQD--VFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDR 876
                R+ ++ L E DG+ S  D  V V+GATNRP  LD A+LR  RF K V+V    + 
Sbjct: 456 -DASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEE 512

Query: 877 ASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEG 936
              L + + + ++        L   L       +G+DL +L  DA    ++    +  + 
Sbjct: 513 TRLLLLKNLLCKQGSPLTQKELAQ-LARMTDGYSGSDLTALAKDAALGPIRELKPEQVKN 571

Query: 937 LEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977
           +   S    + + D  ++  +++ SVS Q L  Y R  + F
Sbjct: 572 MS-ASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDF 611



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 64/213 (30%), Positives = 103/213 (48%), Gaps = 14/213 (6%)

Query: 448 VLKPRLQPGGALLTGTSS----VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAES 503
           V+ P L+P   L TG  +    +LL GPPG GKT +  A  +        +  +SL ++ 
Sbjct: 358 VILPSLRP--ELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKY 415

Query: 504 SGAVETKLQAIFSRARRCRPAVLLLTAVD-LLGRDRDGLGEDARVMAVLRHLLLNEDPLN 562
            G  E  ++A+F+ AR  +P+++ +  VD LL   R+G  + +R +      L+  D + 
Sbjct: 416 VGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKT--EFLIEFDGVQ 473

Query: 563 SC--PPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAH--LPLGQEV 618
           S     ++V+  T+R Q+L   V   F   + V   +E  RL +L+ L      PL Q+ 
Sbjct: 474 SAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK- 532

Query: 619 NLAQLARRCAGFVVGDLYALLTHSSRAACTRIK 651
            LAQLAR   G+   DL AL   ++      +K
Sbjct: 533 ELAQLARMTDGYSGSDLTALAKDAALGPIRELK 565


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score =  132 bits (331), Expect = 2e-30
 Identities = 99/320 (30%), Positives = 160/320 (50%), Gaps = 50/320 (15%)

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAV 757
           P+V W DV GL+  K+ + E + LP++ P L + G R    G+LL GPPGTGK+ LAKAV
Sbjct: 129 PNVKWSDVAGLEGAKEALKEAVILPIKFPHLFT-GKRTPWRGILLFGPPGTGKSYLAKAV 187

Query: 758 ATECS-LTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSG 816
           ATE +  TF S+   +L++ ++G+SE+ V+ +F  AR   P IIF DE+DSL  S  RS 
Sbjct: 188 ATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGS--RSE 245

Query: 817 DSGGVMDRVVSQLLAELDGLHSTQD-VFVIGATNRPDLLDPALLRPGRFDKLVFVGANED 875
           +      R+ ++ L ++ G+    D + V+GATN P +LD A+ R  RF+K +++   E 
Sbjct: 246 NESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYIPLPEP 303

Query: 876 --RASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKR----- 928
             RA+  ++    T+    E        L       +GAD+  +  DA+   +++     
Sbjct: 304 HARAAMFKLHLGTTQNSLTEAD---FRELGRKTDGYSGADISIIVRDALMQPVRKVQSAT 360

Query: 929 ---------------RVHDLEEGLEPGSSAL----------------MLTMEDLLQAAAR 957
                           V DL     PG                    +++M D+L++ + 
Sbjct: 361 HFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSN 420

Query: 958 LQPSVSEQELLRYKRIQRKF 977
            +P+V+E +LL+ K+    F
Sbjct: 421 TKPTVNEHDLLKLKKFTEDF 440



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 49/216 (22%), Positives = 89/216 (41%), Gaps = 17/216 (7%)

Query: 430 WSSLSPPGLEALVSELC-AVLKPRLQPGGALLTGTSS----VLLRGPPGCGKTTVVAAAC 484
           WS ++  GLE     L  AV+ P   P   L TG  +    +LL GPPG GK+ +  A  
Sbjct: 133 WSDVA--GLEGAKEALKEAVILPIKFPH--LFTGKRTPWRGILLFGPPGTGKSYLAKAVA 188

Query: 485 SHL-GLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGE 543
           +         +  S L ++  G  E  ++ +F  AR  +P+++ +  +D L   R     
Sbjct: 189 TEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENES 248

Query: 544 DARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLS 603
           +A        L+  +        ++V+  T+    L + ++  F   + +P      R +
Sbjct: 249 EAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAA 308

Query: 604 ILRALTAHLPLGQ----EVNLAQLARRCAGFVVGDL 635
           + +    HL   Q    E +  +L R+  G+   D+
Sbjct: 309 MFK---LHLGTTQNSLTEADFRELGRKTDGYSGADI 341


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  132 bits (331), Expect = 2e-30
 Identities = 89/285 (31%), Positives = 145/285 (50%), Gaps = 17/285 (5%)

Query: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRR--SGLLLHGPPGTGKTLLAKAV 757
           P V+W D+ G++  K  I E +  P+  P++ + GLR    G+LL GPPGTGKTL+ K +
Sbjct: 396 PPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFT-GLRGPPKGILLFGPPGTGKTLIGKCI 454

Query: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGD 817
           A++   TF S+    L + +VG+ E+ VR +FA AR   P +IF DE+DSL   RG    
Sbjct: 455 ASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEH 514

Query: 818 SGGVMDRVVSQLLAELDGLHSTQD--VFVIGATNRPDLLDPALLRPGRFDKLVFVGANED 875
                 R+ ++ L +LDG  ++ +  + V+GATNRP  +D A  R  R  K +++   E 
Sbjct: 515 ESS--RRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEA 570

Query: 876 RASQLRVLSAITRK---FKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHD 932
            A +  V++ ++++      E    +V   D      +GAD+  LC +A    + R +  
Sbjct: 571 SARKQIVINLMSKEQCCLSEEEIEQIVQQSDA----FSGADMTQLCREASLGPI-RSLQT 625

Query: 933 LEEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977
            +           +   D   A   ++PSVS ++L  Y+   + F
Sbjct: 626 ADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTF 670



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 56/224 (25%), Positives = 101/224 (45%), Gaps = 10/224 (4%)

Query: 439 EALVSELCAVLKPRLQPGGALLTGT----SSVLLRGPPGCGKTTVVAAACSHLGLHLLKV 494
           +A + E+  V+ P L+P   + TG       +LL GPPG GKT +     S  G     +
Sbjct: 410 KATIKEI--VVWPMLRPD--IFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSI 465

Query: 495 PCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVD-LLGRDRDGLGEDARVMAVLRH 553
             SSL ++  G  E  ++A+F+ AR  +PAV+ +  +D LL +  DG  E +R +     
Sbjct: 466 SASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFL 525

Query: 554 LLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSI-LRALTAHL 612
           + L+    +S   ++VV  T+R Q++    +      L +P      R  I +  ++   
Sbjct: 526 VQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMSKEQ 585

Query: 613 PLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLA 656
               E  + Q+ ++   F   D+  L   +S      ++ + +A
Sbjct: 586 CCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIA 629


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,226,054
Number of Sequences: 37866
Number of extensions: 2413934
Number of successful extensions: 9101
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 135
Number of HSP's that attempted gapping in prelim test: 8625
Number of HSP's gapped (non-prelim): 482
length of query: 980
length of database: 18,247,518
effective HSP length: 112
effective length of query: 868
effective length of database: 14,006,526
effective search space: 12157664568
effective search space used: 12157664568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.