Search of human proteins with 17865802

Search of human proteins with 17865802

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
         (444 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]         885   0.0  
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]          723   0.0  
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               246   2e-65
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               246   2e-65
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]              244   1e-64
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     243   3e-64
gi|40806170 spastin isoform 2 [Homo sapiens]                          236   2e-62
gi|11875211 spastin isoform 1 [Homo sapiens]                          236   2e-62
gi|31742536 fidgetin-like 1 [Homo sapiens]                            226   3e-59
gi|112789543 fidgetin-like 1 [Homo sapiens]                           226   3e-59
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     176   4e-44
gi|64084766 fidgetin [Homo sapiens]                                   169   6e-42
gi|6005942 valosin-containing protein [Homo sapiens]                  159   4e-39
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              154   1e-37
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 150   2e-36
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 150   2e-36
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   144   2e-34
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     141   1e-33
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           140   2e-33
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            140   3e-33
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   138   1e-32
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   138   1e-32
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   138   1e-32
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            137   3e-32
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            136   3e-32
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       135   1e-31
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                      132   5e-31
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                       132   5e-31
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           132   8e-31
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             131   1e-30

>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score =  885 bits (2286), Expect = 0.0
 Identities = 444/444 (100%), Positives = 444/444 (100%)

Query: 1   MSSTSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRA 60
           MSSTSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRA
Sbjct: 1   MSSTSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRA 60

Query: 61  KCTEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQL 120
           KCTEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQL
Sbjct: 61  KCTEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQL 120

Query: 121 QGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGK 180
           QGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGK
Sbjct: 121 QGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGK 180

Query: 181 SYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLC 240
           SYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLC
Sbjct: 181 SYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLC 240

Query: 241 GSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPL 300
           GSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPL
Sbjct: 241 GSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPL 300

Query: 301 PEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSAT 360
           PEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSAT
Sbjct: 301 PEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSAT 360

Query: 361 HFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSN 420
           HFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSN
Sbjct: 361 HFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSN 420

Query: 421 TKPTVNEHDLLKLKKFTEDFGQEG 444
           TKPTVNEHDLLKLKKFTEDFGQEG
Sbjct: 421 TKPTVNEHDLLKLKKFTEDFGQEG 444


>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
          Length = 437

 Score =  723 bits (1865), Expect = 0.0
 Identities = 356/440 (80%), Positives = 403/440 (91%), Gaps = 5/440 (1%)

Query: 4   TSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCT 63
           T+  LQKAIDL +KA +EDKA NYEEAL+LYQHAV+YFLH +KYEA  DKAK+SIRAKC 
Sbjct: 2   TTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCV 61

Query: 64  EYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGA 123
           +YLDRAEKLK+YL++KEK  +KPVKE Q   ++ KG+DSD EG  D+PEKKKLQ QL GA
Sbjct: 62  QYLDRAEKLKDYLRSKEKHGKKPVKENQ---SEGKGSDSDSEG--DNPEKKKLQEQLMGA 116

Query: 124 IVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYL 183
           +V+E+PN++W+DVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYL
Sbjct: 117 VVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYL 176

Query: 184 AKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR 243
           AKAVATEANNSTFFS+SSSDL+SKWLGESEKLVKNLF+LAR++KPSIIFIDE+DSLCGSR
Sbjct: 177 AKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR 236

Query: 244 SENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEP 303
           +ENESEAARRIKTEFLVQMQGVG +NDG LVLGATNIPWVLDSAIRRRFEKRIYIPLPE 
Sbjct: 237 NENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEE 296

Query: 304 HARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFK 363
            ARA MF+LHLG+T ++LT+A+  EL RKT+GYSGADISIIVRD+LMQPVRKVQSATHFK
Sbjct: 297 AARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFK 356

Query: 364 KVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSNTKP 423
           KV GPSR +P+ ++DDLLTPCSPGDPGA+EMTWMDVPGDKLLEPVV MSDMLRSL+ T+P
Sbjct: 357 KVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRP 416

Query: 424 TVNEHDLLKLKKFTEDFGQE 443
           TVN  DLLK+KKF+EDFGQE
Sbjct: 417 TVNADDLLKVKKFSEDFGQE 436


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  246 bits (629), Expect = 2e-65
 Identities = 141/328 (42%), Positives = 203/328 (61%), Gaps = 24/328 (7%)

Query: 76  LKNKEKKAQKPVKEGQPSPADEKG--NDSDGEGESDDPE------KKKLQNQLQGAIVIE 127
           +   EK +    K+ +    D+KG  N  DG  + + P+       K L   L+  IV  
Sbjct: 142 ISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSR 201

Query: 128 RPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAV 187
            P++ W D+A LE AK+ L+EAV+LP+  P  F G R PW+G+L+ GPPGTGK+ LAKAV
Sbjct: 202 NPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAV 261

Query: 188 ATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR-SEN 246
           ATE   +TFF++SSS L SK+ GESEKLV+ LF++AR   P+ IFIDEIDS+C  R + +
Sbjct: 262 ATEC-GTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSD 320

Query: 247 ESEAARRIKTEFLVQMQGVG--VDNDG----ILVLGATNIPWVLDSAIRRRFEKRIYIPL 300
           E EA+RR+K+E L+QM GVG  ++ND     ++VL ATN PW +D A+RRR EKRIYIPL
Sbjct: 321 EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPL 380

Query: 301 PEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSAT 360
           P    RA + K++L   +    +    ++  K +GYSGADI+ + RDA +  +R+  +  
Sbjct: 381 PTAKGRAELLKINLREVELD-PDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGL 439

Query: 361 HFKKVRGPSRADPNHLVDDLLTPCSPGD 388
             +++R  S+       ++L  P + GD
Sbjct: 440 SPEEIRALSK-------EELQMPVTKGD 460


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  246 bits (629), Expect = 2e-65
 Identities = 141/328 (42%), Positives = 203/328 (61%), Gaps = 24/328 (7%)

Query: 76  LKNKEKKAQKPVKEGQPSPADEKG--NDSDGEGESDDPE------KKKLQNQLQGAIVIE 127
           +   EK +    K+ +    D+KG  N  DG  + + P+       K L   L+  IV  
Sbjct: 142 ISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSR 201

Query: 128 RPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAV 187
            P++ W D+A LE AK+ L+EAV+LP+  P  F G R PW+G+L+ GPPGTGK+ LAKAV
Sbjct: 202 NPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAV 261

Query: 188 ATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR-SEN 246
           ATE   +TFF++SSS L SK+ GESEKLV+ LF++AR   P+ IFIDEIDS+C  R + +
Sbjct: 262 ATEC-GTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSD 320

Query: 247 ESEAARRIKTEFLVQMQGVG--VDNDG----ILVLGATNIPWVLDSAIRRRFEKRIYIPL 300
           E EA+RR+K+E L+QM GVG  ++ND     ++VL ATN PW +D A+RRR EKRIYIPL
Sbjct: 321 EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPL 380

Query: 301 PEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSAT 360
           P    RA + K++L   +    +    ++  K +GYSGADI+ + RDA +  +R+  +  
Sbjct: 381 PTAKGRAELLKINLREVELD-PDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGL 439

Query: 361 HFKKVRGPSRADPNHLVDDLLTPCSPGD 388
             +++R  S+       ++L  P + GD
Sbjct: 440 SPEEIRALSK-------EELQMPVTKGD 460


>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score =  244 bits (622), Expect = 1e-64
 Identities = 126/256 (49%), Positives = 176/256 (68%), Gaps = 9/256 (3%)

Query: 112 EKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGIL 171
           E ++L   +   I +  PN+KW+D+ GL+ AK+ +KEAV+ PI++P LFTG  +PW+G+L
Sbjct: 160 EMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLL 219

Query: 172 LFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSII 231
           L+GPPGTGK+ LAKAVATE   +TFF+IS+S +VSKW G+SEKLV+ LF+LAR + PS I
Sbjct: 220 LYGPPGTGKTLLAKAVATEC-KTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTI 278

Query: 232 FIDEIDSLC---GSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAI 288
           F+DE++S+    G+ S  E E + R+KTE LVQM G+    D + VL A+N+PW LD A+
Sbjct: 279 FLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAM 338

Query: 289 RRRFEKRIYIPLPEPHARAAMFKLHLGTTQNSL-----TEADFRELGRKTDGYSGADISI 343
            RR EKRI + LP   AR AM    L     S      TE ++  L ++T+GYSG+DI +
Sbjct: 339 LRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKL 398

Query: 344 IVRDALMQPVRKVQSA 359
           + R+A M+PVRK+  A
Sbjct: 399 VCREAAMRPVRKIFDA 414


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  243 bits (620), Expect = 3e-64
 Identities = 139/314 (44%), Positives = 192/314 (61%), Gaps = 23/314 (7%)

Query: 68  RAEKLKEYLKNKEKKAQKP--VKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGAIV 125
           R  + KE  K +E+K + P  V E + +  D  G D D            L   L+  I+
Sbjct: 153 RCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKD------------LVEALERDII 200

Query: 126 IERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAK 185
            + PNV+W D+A L  AK+ LKEAV+LP+  P  F G R PW+G+L+ GPPGTGK+ LAK
Sbjct: 201 SQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAK 260

Query: 186 AVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR-S 244
           AVATE   +TFF++SSS L SK+ GESEKLV+ LF++AR   P+ IFIDEIDS+C  R +
Sbjct: 261 AVATEC-KTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGT 319

Query: 245 ENESEAARRIKTEFLVQMQGVG--VDNDG----ILVLGATNIPWVLDSAIRRRFEKRIYI 298
             E EA+RR+K E LVQM GVG   +ND     ++VL ATN PW +D A+RRR EKRIYI
Sbjct: 320 SEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYI 379

Query: 299 PLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQS 358
           PLP    R  + ++ L   + +  + D   +    +GYSGADI+ + RDA +  +R+   
Sbjct: 380 PLPSAKGREELLRISLRELELA-DDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIE 438

Query: 359 ATHFKKVRGPSRAD 372
               +++R  S+ +
Sbjct: 439 GLTPEEIRNLSKEE 452


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  236 bits (603), Expect = 2e-62
 Identities = 134/293 (45%), Positives = 184/293 (62%), Gaps = 13/293 (4%)

Query: 82  KAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEG 141
           K  +  K   P+ A  K  D       D      L N +   IV     VK+ D+AG + 
Sbjct: 262 KTNRTNKPSTPTTATRKKKDLKNFRNVDS----NLANLIMNEIVDNGTAVKFDDIAGQDL 317

Query: 142 AKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISS 201
           AK+AL+E VILP   P LFTG R P RG+LLFGPPG GK+ LAKAVA E+N +TFF+IS+
Sbjct: 318 AKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESN-ATFFNISA 376

Query: 202 SDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQ 261
           + L SK++GE EKLV+ LF +ARE +PSIIFIDE+DSL   R E E +A+RR+KTEFL++
Sbjct: 377 ASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIE 436

Query: 262 MQGV-GVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHLGTTQNS 320
             GV    +D +LV+GATN P  LD A+ RRF KR+Y+ LP    R  + K  L    + 
Sbjct: 437 FDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSP 496

Query: 321 LTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQ-------SATHFKKVR 366
           LT+ +  +L R TDGYSG+D++ + +DA + P+R+++       SA+  + +R
Sbjct: 497 LTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIR 549


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score =  236 bits (603), Expect = 2e-62
 Identities = 134/293 (45%), Positives = 184/293 (62%), Gaps = 13/293 (4%)

Query: 82  KAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEG 141
           K  +  K   P+ A  K  D       D      L N +   IV     VK+ D+AG + 
Sbjct: 294 KTNRTNKPSTPTTATRKKKDLKNFRNVDS----NLANLIMNEIVDNGTAVKFDDIAGQDL 349

Query: 142 AKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISS 201
           AK+AL+E VILP   P LFTG R P RG+LLFGPPG GK+ LAKAVA E+N +TFF+IS+
Sbjct: 350 AKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESN-ATFFNISA 408

Query: 202 SDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQ 261
           + L SK++GE EKLV+ LF +ARE +PSIIFIDE+DSL   R E E +A+RR+KTEFL++
Sbjct: 409 ASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIE 468

Query: 262 MQGV-GVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHLGTTQNS 320
             GV    +D +LV+GATN P  LD A+ RRF KR+Y+ LP    R  + K  L    + 
Sbjct: 469 FDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSP 528

Query: 321 LTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQ-------SATHFKKVR 366
           LT+ +  +L R TDGYSG+D++ + +DA + P+R+++       SA+  + +R
Sbjct: 529 LTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIR 581


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  226 bits (576), Expect = 3e-59
 Identities = 117/246 (47%), Positives = 168/246 (68%), Gaps = 2/246 (0%)

Query: 115 KLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFG 174
           K+   +   I+   P V W D+AG+E AK  +KE V+ P+  P +FTG R P +GILLFG
Sbjct: 382 KMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFG 441

Query: 175 PPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFID 234
           PPGTGK+ + K +A+++  +TFFSIS+S L SKW+GE EK+V+ LF +AR  +P++IFID
Sbjct: 442 PPGTGKTLIGKCIASQSG-ATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFID 500

Query: 235 EIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDN-DGILVLGATNIPWVLDSAIRRRFE 293
           EIDSL   R + E E++RRIKTEFLVQ+ G    + D ILV+GATN P  +D A RRR  
Sbjct: 501 EIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLV 560

Query: 294 KRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPV 353
           KR+YIPLPE  AR  +    +   Q  L+E +  ++ +++D +SGAD++ + R+A + P+
Sbjct: 561 KRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPI 620

Query: 354 RKVQSA 359
           R +Q+A
Sbjct: 621 RSLQTA 626


>gi|112789543 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  226 bits (576), Expect = 3e-59
 Identities = 117/246 (47%), Positives = 168/246 (68%), Gaps = 2/246 (0%)

Query: 115 KLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFG 174
           K+   +   I+   P V W D+AG+E AK  +KE V+ P+  P +FTG R P +GILLFG
Sbjct: 382 KMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFG 441

Query: 175 PPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFID 234
           PPGTGK+ + K +A+++  +TFFSIS+S L SKW+GE EK+V+ LF +AR  +P++IFID
Sbjct: 442 PPGTGKTLIGKCIASQSG-ATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFID 500

Query: 235 EIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDN-DGILVLGATNIPWVLDSAIRRRFE 293
           EIDSL   R + E E++RRIKTEFLVQ+ G    + D ILV+GATN P  +D A RRR  
Sbjct: 501 EIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLV 560

Query: 294 KRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPV 353
           KR+YIPLPE  AR  +    +   Q  L+E +  ++ +++D +SGAD++ + R+A + P+
Sbjct: 561 KRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPI 620

Query: 354 RKVQSA 359
           R +Q+A
Sbjct: 621 RSLQTA 626


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  176 bits (446), Expect = 4e-44
 Identities = 103/234 (44%), Positives = 143/234 (61%), Gaps = 5/234 (2%)

Query: 130 NVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRT--PWRGILLFGPPGTGKSYLAKAV 187
           +V WSD+AGL+     LK+ VILPIK  HLF   R   P +G+LL+GPPG GK+ +AKA 
Sbjct: 87  HVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKAT 146

Query: 188 ATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENE 247
           A EA    F ++  S L  KW GES+KL   +F LA + +PSIIFIDEIDS   +RS ++
Sbjct: 147 AKEAG-CRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSD 205

Query: 248 SEAARRIKTEFLVQMQGVGVDND-GILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHAR 306
            EA   +K +F+    G+  D+   ++V+GATN P  LDSAI RR   R +I  P    R
Sbjct: 206 HEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQR 265

Query: 307 AAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSAT 360
            A+ KL L   +N     D  E+ ++TDG+SG+D+  + RDA +  VR+  ++T
Sbjct: 266 EAILKLIL-KNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNST 318


>gi|64084766 fidgetin [Homo sapiens]
          Length = 759

 Score =  169 bits (427), Expect = 6e-42
 Identities = 116/396 (29%), Positives = 198/396 (50%), Gaps = 45/396 (11%)

Query: 2   SSTSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFL--HVVKYEAQG---DKAKQ 56
           SS S   +KA  +A +   +   GNY    Q    +  Y +  + +    +G   D++ +
Sbjct: 311 SSASSLKRKAFYMAGQGDMDSSYGNYSYGQQRSTQSPMYRMPDNSISNTNRGNGFDRSAE 370

Query: 57  --SIRAKCTEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGE------GES 108
             S+  K T+ L  +E+ +++     +    P      +    + ++S G+       E 
Sbjct: 371 TSSLAFKPTKQLMSSEQQRKFSSQSSRALTPPSYSTAKNSLGSRSSESFGKYTSPVMSEH 430

Query: 109 DDPEKKKLQNQLQGA------------------------------IVIERPNVKWSDVAG 138
            D  ++ L + +QG                               I+ + P V W+D+AG
Sbjct: 431 GDEHRQLLSHPMQGPGLRAATSSNHSVDEQLKNTDTHLIDLVTNEIITQGPPVDWNDIAG 490

Query: 139 LEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFS 198
           L+  K  +KE V+ P+     F+G     R ILLFGP GTGK+ L + +A++   +TFF 
Sbjct: 491 LDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLG-ATFFK 549

Query: 199 ISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEF 258
           I+ S LV+KWLGE+EK++   F +AR  +PS+IF+ +ID L  S+   E     R++TEF
Sbjct: 550 IAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRMRTEF 609

Query: 259 LVQMQGVGVD-NDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHLGTT 317
           L+Q+  V     D I+V+ AT+ P  +D ++RR F KR+ IPLP+  AR  +    L   
Sbjct: 610 LMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQLLSQH 669

Query: 318 QNSLTEADFRELGRKTDGYSGADISIIVRDALMQPV 353
              L + +F  L ++T+G+SG D++ + ++A++ P+
Sbjct: 670 NYCLNDKEFALLVQRTEGFSGLDVAHLCQEAVVGPL 705


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  159 bits (403), Expect = 4e-39
 Identities = 90/237 (37%), Positives = 140/237 (59%), Gaps = 9/237 (3%)

Query: 125 VIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWRGILLFGPPGTGKSYL 183
           V+E P V W D+ GLE  K  L+E V  P++ P  F     TP +G+L +GPPG GK+ L
Sbjct: 468 VVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLL 527

Query: 184 AKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR 243
           AKA+A E   + F SI   +L++ W GESE  V+ +F  AR+  P ++F DE+DS+  +R
Sbjct: 528 AKAIANECQ-ANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKAR 586

Query: 244 SENESE---AARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYI 298
             N  +   AA R+  + L +M G+    + + ++GATN P ++D AI R  R ++ IYI
Sbjct: 587 GGNIGDGGGAADRVINQILTEMDGMSTKKN-VFIIGATNRPDIIDPAILRPGRLDQLIYI 645

Query: 299 PLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRK 355
           PLP+  +R A+ K +L  +  +  + D   L + T+G+SGAD++ I + A    +R+
Sbjct: 646 PLPDEKSRVAILKANLRKSPVA-KDVDLEFLAKMTNGFSGADLTEICQRACKLAIRE 701



 Score =  149 bits (377), Expect = 4e-36
 Identities = 98/304 (32%), Positives = 159/304 (52%), Gaps = 11/304 (3%)

Query: 131 VKWSDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYLAKAVA 188
           V + D+ G       +KE V LP++ P LF   G + P RGILL+GPPGTGK+ +A+AVA
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPP-RGILLYGPPGTGKTLIARAVA 259

Query: 189 TEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENES 248
            E   + FF I+  +++SK  GESE  ++  F+ A +N P+IIFIDE+D++   R +   
Sbjct: 260 NETG-AFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHG 318

Query: 249 EAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYIPLPEPHAR 306
           E  RRI ++ L  M G+      ++V+ ATN P  +D A+RR  RF++ + I +P+   R
Sbjct: 319 EVERRIVSQLLTLMDGL-KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGR 377

Query: 307 AAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVR 366
             + ++H         + D  ++  +T G+ GAD++ +  +A +Q +RK       +   
Sbjct: 378 LEILQIHT-KNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET 436

Query: 367 GPSRADPNHLV--DDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSNTKPT 424
             +    +  V  DD     S  +P A+  T ++VP     E +  + D+ R L      
Sbjct: 437 IDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVP-QVTWEDIGGLEDVKRELQELVQY 495

Query: 425 VNEH 428
             EH
Sbjct: 496 PVEH 499


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  154 bits (390), Expect = 1e-37
 Identities = 94/232 (40%), Positives = 137/232 (59%), Gaps = 8/232 (3%)

Query: 124 IVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFGPPGTGKSY 182
           I I+ PNV WSD+ GLE  K  L++AV  P+K P  F      P +G+LL+GPPG  K+ 
Sbjct: 617 IAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTM 676

Query: 183 LAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGS 242
           +AKA+A E+  + F +I   +L++K++GESE+ V+  F+ AR   PSIIF DE+D+L   
Sbjct: 677 IAKALANESGLN-FLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVE 735

Query: 243 R--SENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYI 298
           R  S      A R+  + L +M G+    D + +L ATN P  +D A+ R  R ++ IY+
Sbjct: 736 RGSSLGAGNVADRVLAQLLTEMDGIEQLKD-VTILAATNRPDRIDKALMRPGRIDRIIYV 794

Query: 299 PLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALM 350
           PLP+   R  +FKL   +   S  E D  EL  +TD YSGA+I  + R+A +
Sbjct: 795 PLPDAATRREIFKLQFHSMPVS-NEVDLDELILQTDAYSGAEIVAVCREAAL 845



 Score =  154 bits (388), Expect = 2e-37
 Identities = 92/252 (36%), Positives = 141/252 (55%), Gaps = 15/252 (5%)

Query: 110 DPEKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPW-R 168
           D   K+  NQ +         V +  + GL    +A++E + LP+K P LF     P  R
Sbjct: 338 DKNSKEQDNQFK---------VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPR 388

Query: 169 GILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKP 228
           G+LL+GPPGTGK+ +A+AVA E   +    I+  +++SK+ GE+E  ++ +F  A    P
Sbjct: 389 GVLLYGPPGTGKTMIARAVANEVG-AYVSVINGPEIISKFYGETEAKLRQIFAEATLRHP 447

Query: 229 SIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVG--VDNDGILVLGATNIPWVLDS 286
           SIIFIDE+D+LC  R   ++E  +R+    L  M G+G  V    +LVLGATN P  LD+
Sbjct: 448 SIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDA 507

Query: 287 AIRR--RFEKRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISII 344
           A+RR  RF+K I I +P    R  + +  L    + LTEA+  +L     GY GAD+ ++
Sbjct: 508 ALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVL 567

Query: 345 VRDALMQPVRKV 356
             +A +  +R++
Sbjct: 568 CNEAGLCALRRI 579


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  150 bits (380), Expect = 2e-36
 Identities = 103/321 (32%), Positives = 168/321 (52%), Gaps = 23/321 (7%)

Query: 63  TEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQG 122
           +E  D  ++L   L++     Q P+ E Q      + ND      S  P  K+     +G
Sbjct: 416 SETQDELQRLLGLLRD-----QDPLSEEQMQGLCIELNDFIVALSSVQPSAKR-----EG 465

Query: 123 AIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGK 180
            + +  PNV W+D+  LE  +E L  A++ P++ P  F   G  TP  G+LL GPPG GK
Sbjct: 466 FVTV--PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGK 522

Query: 181 SYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLC 240
           + LAKAVA E+  + F S+   +L++ ++GESE+ V+ +FQ A+ + P +IF DE+D+LC
Sbjct: 523 TLLAKAVANESGLN-FISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC 581

Query: 241 GSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYI 298
             RS+ E+ A+ R+  + L +M G+      + ++ ATN P ++D AI R  R +K +++
Sbjct: 582 PRRSDRETGASVRVVNQLLTEMDGLEA-RQQVFIMAATNRPDIIDPAILRPGRLDKTLFV 640

Query: 299 PLPEPHARAAMFKLHLGTTQNSLTEADFR----ELGRKTDGYSGADISIIVRDALMQPVR 354
            LP P  R A+ K           +AD          + D Y+GAD+S +VR+A +  +R
Sbjct: 641 GLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALR 700

Query: 355 KVQSATHFKKVRGPSRADPNH 375
           +  +       +G  +    H
Sbjct: 701 QEMARQKSGNEKGELKVSHKH 721



 Score =  123 bits (308), Expect = 4e-28
 Identities = 105/321 (32%), Positives = 158/321 (49%), Gaps = 30/321 (9%)

Query: 60  AKCTEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQ 119
           +K +  L+   K K  LKNK  K +K           E   + DGE E+   +K K +  
Sbjct: 101 SKDSSLLESDMKRKGKLKNKGSKRKK-----------EDLQEVDGEIEAVLQKKAKARG- 148

Query: 120 LQGAIVIERPNVKWSDVAGLEGA-KEALKEAVIL--PIKFPHLFTGKRTPWRGILLFGPP 176
               +  +  NVK+ DV G +   KE  K  + +  P  + HL      P RG+LL GPP
Sbjct: 149 ----LEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGV---VPPRGVLLHGPP 201

Query: 177 GTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEI 236
           G GK+ LA A+A E +      +++ ++VS   GESE+ ++ LF+ A  N P IIFIDEI
Sbjct: 202 GCGKTLLAHAIAGELD-LPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEI 260

Query: 237 DSLCGSRSENESEAARRIKTEFLVQMQGVG--VDNDGILVLGATNIPWVLDSAIRR--RF 292
           D++   R     +  RRI  + L  M  +        +LV+GATN P  LD A+RR  RF
Sbjct: 261 DAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRF 320

Query: 293 EKRIYIPLPEPHARAAMFKLHLGTTQNSLTEA-DFRELGRKTDGYSGADISIIVRDALMQ 351
           ++ I + +P+  +R  +  L     +  L +A DF  L   T G+ GAD+  + R+A M 
Sbjct: 321 DREICLGIPDEASRERI--LQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMC 378

Query: 352 PVRKVQSATHFKKVRGPSRAD 372
            V +V      ++ + P   D
Sbjct: 379 AVNRVLMKLQEQQKKNPEMED 399


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  150 bits (380), Expect = 2e-36
 Identities = 103/321 (32%), Positives = 168/321 (52%), Gaps = 23/321 (7%)

Query: 63  TEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQG 122
           +E  D  ++L   L++     Q P+ E Q      + ND      S  P  K+     +G
Sbjct: 522 SETQDELQRLLGLLRD-----QDPLSEEQMQGLCIELNDFIVALSSVQPSAKR-----EG 571

Query: 123 AIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGK 180
            + +  PNV W+D+  LE  +E L  A++ P++ P  F   G  TP  G+LL GPPG GK
Sbjct: 572 FVTV--PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGK 628

Query: 181 SYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLC 240
           + LAKAVA E+  + F S+   +L++ ++GESE+ V+ +FQ A+ + P +IF DE+D+LC
Sbjct: 629 TLLAKAVANESGLN-FISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC 687

Query: 241 GSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYI 298
             RS+ E+ A+ R+  + L +M G+      + ++ ATN P ++D AI R  R +K +++
Sbjct: 688 PRRSDRETGASVRVVNQLLTEMDGLEA-RQQVFIMAATNRPDIIDPAILRPGRLDKTLFV 746

Query: 299 PLPEPHARAAMFKLHLGTTQNSLTEADFR----ELGRKTDGYSGADISIIVRDALMQPVR 354
            LP P  R A+ K           +AD          + D Y+GAD+S +VR+A +  +R
Sbjct: 747 GLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALR 806

Query: 355 KVQSATHFKKVRGPSRADPNH 375
           +  +       +G  +    H
Sbjct: 807 QEMARQKSGNEKGELKVSHKH 827



 Score =  123 bits (308), Expect = 4e-28
 Identities = 105/321 (32%), Positives = 158/321 (49%), Gaps = 30/321 (9%)

Query: 60  AKCTEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQ 119
           +K +  L+   K K  LKNK  K +K           E   + DGE E+   +K K +  
Sbjct: 207 SKDSSLLESDMKRKGKLKNKGSKRKK-----------EDLQEVDGEIEAVLQKKAKARG- 254

Query: 120 LQGAIVIERPNVKWSDVAGLEGA-KEALKEAVIL--PIKFPHLFTGKRTPWRGILLFGPP 176
               +  +  NVK+ DV G +   KE  K  + +  P  + HL      P RG+LL GPP
Sbjct: 255 ----LEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGV---VPPRGVLLHGPP 307

Query: 177 GTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEI 236
           G GK+ LA A+A E +      +++ ++VS   GESE+ ++ LF+ A  N P IIFIDEI
Sbjct: 308 GCGKTLLAHAIAGELD-LPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEI 366

Query: 237 DSLCGSRSENESEAARRIKTEFLVQMQGVG--VDNDGILVLGATNIPWVLDSAIRR--RF 292
           D++   R     +  RRI  + L  M  +        +LV+GATN P  LD A+RR  RF
Sbjct: 367 DAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRF 426

Query: 293 EKRIYIPLPEPHARAAMFKLHLGTTQNSLTEA-DFRELGRKTDGYSGADISIIVRDALMQ 351
           ++ I + +P+  +R  +  L     +  L +A DF  L   T G+ GAD+  + R+A M 
Sbjct: 427 DREICLGIPDEASRERI--LQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMC 484

Query: 352 PVRKVQSATHFKKVRGPSRAD 372
            V +V      ++ + P   D
Sbjct: 485 AVNRVLMKLQEQQKKNPEMED 505


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  144 bits (363), Expect = 2e-34
 Identities = 89/234 (38%), Positives = 131/234 (55%), Gaps = 10/234 (4%)

Query: 130 NVKWSDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWRGILLFGPPGTGKSYLAKAVA 188
           +V++  + GL     ALKE V+ P+ +P +F   K  P RG L +GPPGTGK+ +A+A+A
Sbjct: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455

Query: 189 TEANNS----TFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRS 244
            E +       FF    +D +SKW+GESE+ ++ LF  A   +PSIIF DEID L   RS
Sbjct: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515

Query: 245 ENESEAARRIKTEFLVQMQGVGVDNDG-ILVLGATNIPWVLDSAIRR--RFEKRIYIPLP 301
             + +    I +  L  M   G+DN G I+V+GATN    +D A+RR  RF++     LP
Sbjct: 516 SRQDQIHSSIVSTLLALMD--GLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLP 573

Query: 302 EPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRK 355
           +  AR  + ++H       L++A   EL  K  GY GADI  +  +A +  +R+
Sbjct: 574 DQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRR 627


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  141 bits (356), Expect = 1e-33
 Identities = 88/234 (37%), Positives = 128/234 (54%), Gaps = 10/234 (4%)

Query: 130 NVKWSDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWRGILLFGPPGTGKSYLAKAVA 188
           +V++  V GL     ALKE V+ P+ +P +F   K  P RG L +GPPGTGK+ +A+A+A
Sbjct: 422 SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALA 481

Query: 189 TEANNS----TFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRS 244
            E +       FF    +D +SKW+GESE+ ++ LF  A + +PSIIF DEID L   RS
Sbjct: 482 NECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRS 541

Query: 245 ENESEAARRIKTEFLVQMQGVGVDNDG-ILVLGATNIPWVLDSAIRR--RFEKRIYIPLP 301
             + +    I +  L  M   G+D+ G I+V+GATN    +D A+RR  RF++     LP
Sbjct: 542 SRQDQIHSSIVSTLLALMD--GLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLP 599

Query: 302 EPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRK 355
           +  AR  + K+H         +    EL     GY GADI  I  +A +  +R+
Sbjct: 600 DKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRR 653


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  140 bits (354), Expect = 2e-33
 Identities = 86/231 (37%), Positives = 136/231 (58%), Gaps = 9/231 (3%)

Query: 130 NVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFGPPGTGKSYLAKAVA 188
           NV +S++ GL      L+E + LP+  P LF      P +G LL+GPPGTGK+ LA+AVA
Sbjct: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202

Query: 189 TEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENES 248
           ++ +   F  + SS +V K++GES +L++ +F  AR+++P IIF+DEID++ G R    +
Sbjct: 203 SQLD-CNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGT 261

Query: 249 EAARRIK---TEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYIPLPEP 303
            A R I+    E L QM G    +  + ++ ATN P  LD A+ R  R +++I+I LP  
Sbjct: 262 SADREIQRTLMELLNQMDGFDTLH-RVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNE 320

Query: 304 HARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVR 354
            AR  + K+H G       E D+  + + +DG++GAD+  +  +A M  +R
Sbjct: 321 QARLDILKIHAGPITKH-GEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIR 370


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  140 bits (352), Expect = 3e-33
 Identities = 84/237 (35%), Positives = 136/237 (57%), Gaps = 9/237 (3%)

Query: 125 VIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFGPPGTGKSYL 183
           V ERP  ++SD+ GL+   + L EA++LP+     F      P +G+L++GPPGTGK+ L
Sbjct: 177 VDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLL 236

Query: 184 AKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR 243
           A+A A +   +TF  ++   LV  ++G+  KLV++ F LA+E  PSIIFIDE+D++   R
Sbjct: 237 ARACAAQTK-ATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKR 295

Query: 244 SENESEAARRIK---TEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYI 298
            ++E    R ++    E L Q+ G    N  + V+ ATN   +LD A+ R  R +++I  
Sbjct: 296 FDSEKAGDREVQRTMLELLNQLDGF-QPNTQVKVIAATNRVDILDPALLRSGRLDRKIEF 354

Query: 299 PLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRK 355
           P+P   ARA + ++H     N   + ++ EL R TD ++GA    +  +A M  +R+
Sbjct: 355 PMPNEEARARIMQIH-SRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRR 410


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  138 bits (347), Expect = 1e-32
 Identities = 87/235 (37%), Positives = 139/235 (59%), Gaps = 9/235 (3%)

Query: 127 ERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFGPPGTGKSYLAK 185
           ++P+V ++D+ G++  K+ ++EAV LP+    L+      P RG+L++GPPG GK+ LAK
Sbjct: 154 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 213

Query: 186 AVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSE 245
           AVA     + F  +  S+ V K+LGE  ++V+++F+LA+EN P+IIFIDEID++   R +
Sbjct: 214 AVAHHTT-AAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD 272

Query: 246 NESEAAR---RIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYIPL 300
            ++ A R   RI  E L QM G    N  + V+ ATN    LD A+ R  R +++I  PL
Sbjct: 273 AQTGADREVQRILLELLNQMDGFD-QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPL 331

Query: 301 PEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRK 355
           P+   +  +F   + +  N   E D  +   + D  SGADI+ I +++ M  VR+
Sbjct: 332 PDRRQKRLIFST-ITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRE 385


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  138 bits (347), Expect = 1e-32
 Identities = 87/235 (37%), Positives = 139/235 (59%), Gaps = 9/235 (3%)

Query: 127 ERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFGPPGTGKSYLAK 185
           ++P+V ++D+ G++  K+ ++EAV LP+    L+      P RG+L++GPPG GK+ LAK
Sbjct: 127 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 186

Query: 186 AVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSE 245
           AVA     + F  +  S+ V K+LGE  ++V+++F+LA+EN P+IIFIDEID++   R +
Sbjct: 187 AVAHHTT-AAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD 245

Query: 246 NESEAAR---RIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYIPL 300
            ++ A R   RI  E L QM G    N  + V+ ATN    LD A+ R  R +++I  PL
Sbjct: 246 AQTGADREVQRILLELLNQMDGFD-QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPL 304

Query: 301 PEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRK 355
           P+   +  +F   + +  N   E D  +   + D  SGADI+ I +++ M  VR+
Sbjct: 305 PDRRQKRLIFST-ITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRE 358


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  138 bits (347), Expect = 1e-32
 Identities = 87/235 (37%), Positives = 139/235 (59%), Gaps = 9/235 (3%)

Query: 127 ERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLFGPPGTGKSYLAK 185
           ++P+V ++D+ G++  K+ ++EAV LP+    L+      P RG+L++GPPG GK+ LAK
Sbjct: 158 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 217

Query: 186 AVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSE 245
           AVA     + F  +  S+ V K+LGE  ++V+++F+LA+EN P+IIFIDEID++   R +
Sbjct: 218 AVAHHTT-AAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD 276

Query: 246 NESEAAR---RIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYIPL 300
            ++ A R   RI  E L QM G    N  + V+ ATN    LD A+ R  R +++I  PL
Sbjct: 277 AQTGADREVQRILLELLNQMDGFD-QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPL 335

Query: 301 PEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRK 355
           P+   +  +F   + +  N   E D  +   + D  SGADI+ I +++ M  VR+
Sbjct: 336 PDRRQKRLIFST-ITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRE 389


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  137 bits (344), Expect = 3e-32
 Identities = 91/244 (37%), Positives = 140/244 (57%), Gaps = 12/244 (4%)

Query: 120 LQGAIVIER-PNVKWSDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPP 176
           L   +++E+ P+  +  + GL+   + +KE + LP+K P LF   G   P +G+LL+GPP
Sbjct: 134 LVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQP-KGVLLYGPP 192

Query: 177 GTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEI 236
           GTGK+ LA+AVA   +  TF  +S S+LV K++GE  ++V+ LF +ARE+ PSIIF+DEI
Sbjct: 193 GTGKTLLARAVAHHTD-CTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEI 251

Query: 237 DSLCGSRSENES---EAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--R 291
           DS+  SR E  S      +R   E L Q+ G     + I V+ ATN   +LDSA+ R  R
Sbjct: 252 DSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKN-IKVIMATNRIDILDSALLRPGR 310

Query: 292 FEKRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQ 351
            +++I  P P   AR  + K+H     N     + R++     G SGA++  +  +A M 
Sbjct: 311 IDRKIEFPPPNEEARLDILKIH-SRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMY 369

Query: 352 PVRK 355
            +R+
Sbjct: 370 ALRE 373


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  136 bits (343), Expect = 3e-32
 Identities = 87/239 (36%), Positives = 142/239 (59%), Gaps = 13/239 (5%)

Query: 125 VIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSY 182
           V + P   ++D+ GL+   + +KE+V LP+  P  +   G + P +G++L+GPPGTGK+ 
Sbjct: 176 VEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPP-KGVILYGPPGTGKTL 234

Query: 183 LAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGS 242
           LAKAVA + + +TF  +  S+L+ K+LG+  KLV+ LF++A E+ PSI+FIDEID++   
Sbjct: 235 LAKAVANQTS-ATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTK 293

Query: 243 RSENESEAARRIK---TEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIY 297
           R ++ S   R I+    E L Q+ G     D + V+ ATN    LD A+ R  R +++I 
Sbjct: 294 RYDSNSGGEREIQRTMLELLNQLDGFDSRGD-VKVIMATNRIETLDPALIRPGRIDRKIE 352

Query: 298 IPLPEPHARAAMFKLHLGTTQNSLT-EADFRELGRKTDGYSGADISIIVRDALMQPVRK 355
            PLP+   +  +F++H  T++ +L  +    +L    D  SGADI  I  +A +  +R+
Sbjct: 353 FPLPDEKTKKRIFQIH--TSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRE 409


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  135 bits (339), Expect = 1e-31
 Identities = 85/244 (34%), Positives = 139/244 (56%), Gaps = 27/244 (11%)

Query: 131 VKWSDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYLAKAVA 188
           V W ++ GLE  K  LK+++  P+KFP  F   G   P +G+LL+GPPG  K+ L +A+A
Sbjct: 461 VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQP-KGVLLYGPPGCAKTTLVRALA 519

Query: 189 TEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENES 248
           T  + S F S+S +DL S ++G+SEK++  +F+ AR + P+I+F+DEIDS+ G+RS +++
Sbjct: 520 TSCHCS-FVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKT 578

Query: 249 --EAARRIKTEFLVQMQGVG------------------VDNDGILVLGATNIPWVLDSAI 288
             +   R+ +  L ++ GVG                  V N  ++++ ATN P VLD+A+
Sbjct: 579 GCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTAL 638

Query: 289 RR--RFEKRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVR 346
            R  R +K IYIP P+   R ++ K+   T      +     L  +T  +SGAD+  +  
Sbjct: 639 LRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIG-PDVSLENLAAETCFFSGADLRNLCT 697

Query: 347 DALM 350
           +A +
Sbjct: 698 EAAL 701



 Score =  119 bits (299), Expect = 4e-27
 Identities = 79/222 (35%), Positives = 125/222 (56%), Gaps = 13/222 (5%)

Query: 136 VAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYLAKAVATEANN 193
           + GL  A ++L+E + LP+++P   T  G   P RG+LL GPPG GK+ L +AVA EA  
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVP-RGVLLAGPPGVGKTQLVRAVAREA-G 259

Query: 194 STFFSISSSDLVSKWLGESEKLVKNLFQLARE---NKPSIIFIDEIDSLCGSRSENESEA 250
           +   ++S+  L     GE+E+ V+ +FQ ARE     PS++F+DE+D+LC  R     E+
Sbjct: 260 AELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSRAPES 319

Query: 251 ARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYIPLPEPHARAA 308
             R+  + L  + G   D + ++V+GATN P  LD A+RR  RF++ + I  P    R  
Sbjct: 320 --RVVAQVLTLLDGASGDRE-VVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKE 376

Query: 309 MFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALM 350
           + ++ + +     +  D   L   T GY GAD++ + R+A M
Sbjct: 377 ILQV-ITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAM 417


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score =  132 bits (333), Expect = 5e-31
 Identities = 85/231 (36%), Positives = 135/231 (58%), Gaps = 10/231 (4%)

Query: 126 IERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYL 183
           ++  NV +  V G+E AK+ L+E V   +K P  FT  G + P +GILL GPPGTGK+ L
Sbjct: 331 VQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLP-KGILLVGPPGTGKTLL 388

Query: 184 AKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR 243
           A+AVA EA+   F+  S S+    ++G     ++NLF+ A+ N P +IFIDE+DS+ G R
Sbjct: 389 ARAVAGEAD-VPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKR 447

Query: 244 SENESEA-ARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYIPL 300
            E+     +R+   + L +M G    N+G++++GATN P  LD+A+ R  RF+ ++ +P 
Sbjct: 448 IESPMHPYSRQTINQLLAEMDGF-KPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPR 506

Query: 301 PEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQ 351
           P+   R  + K +L   +      D   + R T G+SGA++  +V  A ++
Sbjct: 507 PDVKGRTEILKWYLNKIKFD-QSVDPEIIARGTVGFSGAELENLVNQAALK 556


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score =  132 bits (333), Expect = 5e-31
 Identities = 85/231 (36%), Positives = 135/231 (58%), Gaps = 10/231 (4%)

Query: 126 IERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYL 183
           ++  NV +  V G+E AK+ L+E V   +K P  FT  G + P +GILL GPPGTGK+ L
Sbjct: 274 VQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLP-KGILLVGPPGTGKTLL 331

Query: 184 AKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR 243
           A+AVA EA+   F+  S S+    ++G     ++NLF+ A+ N P +IFIDE+DS+ G R
Sbjct: 332 ARAVAGEAD-VPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKR 390

Query: 244 SENESEA-ARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYIPL 300
            E+     +R+   + L +M G    N+G++++GATN P  LD+A+ R  RF+ ++ +P 
Sbjct: 391 IESPMHPYSRQTINQLLAEMDGF-KPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPR 449

Query: 301 PEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQ 351
           P+   R  + K +L   +      D   + R T G+SGA++  +V  A ++
Sbjct: 450 PDVKGRTEILKWYLNKIKFD-QSVDPEIIARGTVGFSGAELENLVNQAALK 499


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  132 bits (331), Expect = 8e-31
 Identities = 99/320 (30%), Positives = 160/320 (50%), Gaps = 50/320 (15%)

Query: 129 PNVKWSDVAGLEGAKEALKEAVILPIKFPHLFT-GKRTPWRGILLFGPPGTGKSYLAKAV 187
           P+V W DV GL+  K+ + E + LP++ P L + G R    G+LL GPPGTGK+ LAKAV
Sbjct: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS--GLLLHGPPGTGKTLLAKAV 757

Query: 188 ATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGS--RSE 245
           ATE +  TF S+   +L++ ++G+SE+ V+ +F  AR   P IIF DE+DSL  S  RS 
Sbjct: 758 ATECS-LTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSG 816

Query: 246 NESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYIPLPEP 303
           +      R+ ++ L ++ G+    D + V+GATN P +LD A+ R  RF+K +++   E 
Sbjct: 817 DSGGVMDRVVSQLLAELDGLHSTQD-VFVIGATNRPDLLDPALLRPGRFDKLVFVGANED 875

Query: 304 HARAAMFKLHLGTTQNSLTEAD---FRELGRKTDGYSGADISIIVRDALMQPVRKVQSAT 360
             RA+  ++    T+    E        L       +GAD+  +  DA+   +++     
Sbjct: 876 --RASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKR----- 928

Query: 361 HFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSN 420
                           V DL     PG                    +++M D+L++ + 
Sbjct: 929 ---------------RVHDLEEGLEPGSSAL----------------MLTMEDLLQAAAR 957

Query: 421 TKPTVNEHDLLKLKKFTEDF 440
            +P+V+E +LL+ K+    F
Sbjct: 958 LQPSVSEQELLRYKRIQRKF 977



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 49/216 (22%), Positives = 89/216 (41%), Gaps = 17/216 (7%)

Query: 133 WSDVA--GLEGAKEALKEAVILPIKFPH--LFTGKRTPWRGILLFGPPGTGKSYLAKAVA 188
           WS ++  GLE     L  AV+ P   P   L TG  +    +LL GPPG GK+ +  A  
Sbjct: 430 WSSLSPPGLEALVSELC-AVLKPRLQPGGALLTGTSS----VLLRGPPGCGKTTVVAAAC 484

Query: 189 TEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENES 248
           +         +  S L ++  G  E  ++ +F  AR  +P+++ +  +D L   R     
Sbjct: 485 SHL-GLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGE 543

Query: 249 EAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAA 308
           +A        L+  +        ++V+  T+    L + ++  F   + +P      R +
Sbjct: 544 DARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLS 603

Query: 309 MFK---LHLGTTQNSLTEADFRELGRKTDGYSGADI 341
           + +    HL   Q    E +  +L R+  G+   D+
Sbjct: 604 ILRALTAHLPLGQ----EVNLAQLARRCAGFVVGDL 635


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  131 bits (329), Expect = 1e-30
 Identities = 98/306 (32%), Positives = 160/306 (52%), Gaps = 14/306 (4%)

Query: 60  AKCTEYLDRAEKLKEYLKNKEKKAQKPVK-EGQPSPAD-EKG---NDSDGEGESDDPEKK 114
           A+CT+ ++   +  +Y+ N ++ A+  V    Q +P D E+G        + +   P   
Sbjct: 96  ARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPP 155

Query: 115 KLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRT-PWRGILLF 173
           K+   +    V E+P+V +SDV G +   E L+E V  P+  P  F      P +G+LLF
Sbjct: 156 KIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLF 215

Query: 174 GPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFI 233
           GPPGTGK+  A+AVA   + + F  +  S+LV K++GE  ++V+ LF++AR  K  +IF 
Sbjct: 216 GPPGTGKTLCARAVANRTD-ACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFF 274

Query: 234 DEIDSLCGSRSENES---EAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR 290
           DEID++ G+R ++ +      +R   E + Q+ G       I VL ATN P  LD A+ R
Sbjct: 275 DEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFD-PRGNIKVLMATNRPDTLDPALMR 333

Query: 291 --RFEKRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDA 348
             R +++I   LP+   R  +FK+H   + +   +  F  L R     +GA+I  +  +A
Sbjct: 334 PGRLDRKIEFSLPDLEGRTHIFKIH-ARSMSVERDIRFELLARLCPNSTGAEIRSVCTEA 392

Query: 349 LMQPVR 354
            M  +R
Sbjct: 393 GMFAIR 398


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.132    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,201,974
Number of Sequences: 37866
Number of extensions: 798519
Number of successful extensions: 3694
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 87
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 3247
Number of HSP's gapped (non-prelim): 357
length of query: 444
length of database: 18,247,518
effective HSP length: 105
effective length of query: 339
effective length of database: 14,271,588
effective search space: 4838068332
effective search space used: 4838068332
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.