Guide to the Human Genome
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Search of human proteins with 14192943

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
         (1140 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]              2602   0.0  
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]             1494   0.0  
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s...   871   0.0  
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               717   0.0  
gi|134244285 Notch homolog 3 [Homo sapiens]                           282   1e-75
gi|148833508 notch1 preproprotein [Homo sapiens]                      281   2e-75
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]           281   2e-75
gi|33598931 scavenger receptor class F, member 1 isoform 3 precu...   276   1e-73
gi|33598929 scavenger receptor class F, member 1 isoform 1 precu...   276   1e-73
gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo...   275   1e-73
gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo...   275   1e-73
gi|55770876 notch4 preproprotein [Homo sapiens]                       274   4e-73
gi|24041035 notch 2 preproprotein [Homo sapiens]                      270   8e-72
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               234   5e-61
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               229   9e-60
gi|153946395 tenascin C precursor [Homo sapiens]                      220   5e-57
gi|4557679 jagged 1 precursor [Homo sapiens]                          218   2e-56
gi|21264602 laminin alpha 5 [Homo sapiens]                            208   2e-53
gi|122937283 6720455I24Rik homolog [Homo sapiens]                     206   1e-52
gi|145309306 scavenger receptor class F, member 1 isoform 5 prec...   205   2e-52
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s...   182   1e-45
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa...   182   1e-45
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]               178   2e-44
gi|38788416 laminin, alpha 1 precursor [Homo sapiens]                 175   3e-43
gi|119703755 laminin, beta 2 precursor [Homo sapiens]                 172   2e-42
gi|143770880 laminin, beta 4 [Homo sapiens]                           163   8e-40
gi|167614504 laminin, beta 1 precursor [Homo sapiens]                 161   4e-39
gi|110735443 delta-like 1 [Homo sapiens]                              150   5e-36
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]   145   3e-34
gi|41327708 crumbs homolog 1 precursor [Homo sapiens]                 145   3e-34

>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
          Length = 1140

 Score = 2602 bits (6744), Expect = 0.0
 Identities = 1140/1140 (100%), Positives = 1140/1140 (100%)

Query: 1    MVISLNSCLSFICLLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSC 60
            MVISLNSCLSFICLLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSC
Sbjct: 1    MVISLNSCLSFICLLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSC 60

Query: 61   TDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIA 120
            TDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIA
Sbjct: 61   TDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIA 120

Query: 121  PNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCED 180
            PNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCED
Sbjct: 121  PNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCED 180

Query: 181  RCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPC 240
            RCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPC
Sbjct: 181  RCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPC 240

Query: 241  QNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSP 300
            QNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSP
Sbjct: 241  QNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSP 300

Query: 301  GYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLY 360
            GYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLY
Sbjct: 301  GYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLY 360

Query: 361  GIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGAD 420
            GIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGAD
Sbjct: 361  GIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGAD 420

Query: 421  CDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGV 480
            CDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGV
Sbjct: 421  CDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGV 480

Query: 481  DCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAE 540
            DCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAE
Sbjct: 481  DCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAE 540

Query: 541  RCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGIC 600
            RCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGIC
Sbjct: 541  RCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGIC 600

Query: 601  ECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVC 660
            ECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVC
Sbjct: 601  ECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVC 660

Query: 661  PSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHN 720
            PSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHN
Sbjct: 661  PSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHN 720

Query: 721  GAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGF 780
            GAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGF
Sbjct: 721  GAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGF 780

Query: 781  MGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLN 840
            MGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLN
Sbjct: 781  MGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLN 840

Query: 841  SLSRTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMR 900
            SLSRTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMR
Sbjct: 841  SLSRTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMR 900

Query: 901  VVNADYTISGTLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFV 960
            VVNADYTISGTLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFV
Sbjct: 901  VVNADYTISGTLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFV 960

Query: 961  NLKNVNPGKRGPVGDCTGTLPADWKHGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSN 1020
            NLKNVNPGKRGPVGDCTGTLPADWKHGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSN
Sbjct: 961  NLKNVNPGKRGPVGDCTGTLPADWKHGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSN 1020

Query: 1021 CSLSSSENPYATIKDPPVLIPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPT 1080
            CSLSSSENPYATIKDPPVLIPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPT
Sbjct: 1021 CSLSSSENPYATIKDPPVLIPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPT 1080

Query: 1081 VSVVQGVFSNNGRLSQDPYDLPKNSHIPCHYDLLPVRDSSSSPKQEDSGGSSSNSSSSSE 1140
            VSVVQGVFSNNGRLSQDPYDLPKNSHIPCHYDLLPVRDSSSSPKQEDSGGSSSNSSSSSE
Sbjct: 1081 VSVVQGVFSNNGRLSQDPYDLPKNSHIPCHYDLLPVRDSSSSPKQEDSGGSSSNSSSSSE 1140


>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
          Length = 1044

 Score = 1494 bits (3867), Expect = 0.0
 Identities = 598/911 (65%), Positives = 720/911 (79%), Gaps = 8/911 (0%)

Query: 1   MVISLNSCLSFICLLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSC 60
           MV+SL   ++F       ++     LN EDPNVCSHWESY+VTVQESY HPFDQIYYT C
Sbjct: 1   MVLSLTGLIAF------SFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRC 54

Query: 61  TDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIA 120
           TDILNWFKCTRHR+SY+TAYR G +TMYRR+SQCCPG+YESG+ C+P C ++CVHGRC++
Sbjct: 55  TDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVS 114

Query: 121 PNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCED 180
           P+TC CEPGWGG +CSS CD DHWGPHC++RCQC+NGALCNPITGAC CAAGFRGWRCE+
Sbjct: 115 PDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEE 174

Query: 181 RCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPC 240
            C  GT+G  C   CQC++GA+CD   GEC C PGYTG +CE+LCPPG HG  CE RCPC
Sbjct: 175 LCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPC 234

Query: 241 QNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSP 300
           QNGG CHH+TGEC+CP GW G VC QPCP G FG+NCSQ+C CH+GG CD  TGQCHC+ 
Sbjct: 235 QNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTA 294

Query: 301 GYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLY 360
           GY G+RCQ+ECP G++G  C++ C C NGG+C   +GAC CE G+ G RC+ RLCPEGL+
Sbjct: 295 GYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLH 354

Query: 361 GIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGAD 420
           G  C   CPC  +NT SCHP++G C C+PGWSG +CNE+C  G+YG+ CQ  C+CQNGAD
Sbjct: 355 GPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGAD 414

Query: 421 CDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGV 480
           C S+TG CTCAPGF G  C+  C  GTYG NCSS C C N   CSPVDGSCTCK GW G+
Sbjct: 415 CHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGL 474

Query: 481 DCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAE 540
           DC++ CPSGTWG  CN +C C NG AC+ +DG+C+C PGW G+ CELPC DGT+GLNC+E
Sbjct: 475 DCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSE 534

Query: 541 RCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGIC 600
            CDCSHADGC P TGHC CL GW+G+ CDS C  GRWGPNCS+ C C+NG SCSP+DG C
Sbjct: 535 HCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSC 594

Query: 601 ECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVC 660
           ECAPGFRG  CQRIC PGFYGH C+Q CP CVHSS PCHHI+G+C+CLPGF+GALCN+VC
Sbjct: 595 ECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVC 654

Query: 661 PSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHN 720
             G FG++CA +C+C NNGTC+PID SCQC+PGWIG DCSQ CPP  WGP C H C+CHN
Sbjct: 655 AGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHN 714

Query: 721 GAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGF 780
           GA CSA DG C CTPGWTGL+CTQRCP  F+GKDC  +CQCQNGA CDHISG+CTCRTGF
Sbjct: 715 GASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGF 774

Query: 781 MGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLN 840
            G+HCEQ+C  GT+GYGC+Q+C+C+NNSTCDH+TGTCYCSPG+KG RCDQA  +++  LN
Sbjct: 775 TGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQA-ALMMEELN 833

Query: 841 SLSRTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSM-PAVTYTPAM 899
             ++ S AL A+ + +GA+ GI++L+ +++ LL LF  +R +QK K   + P V+YTPAM
Sbjct: 834 PYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAM 893

Query: 900 RVVNADYTISG 910
           R+ + DY++SG
Sbjct: 894 RMTSTDYSLSG 904



 Score =  149 bits (375), Expect = 2e-35
 Identities = 76/138 (55%), Positives = 94/138 (68%), Gaps = 4/138 (2%)

Query: 994  GAFGLDRSY----MGKSLKDLGKNSEYNSSNCSLSSSENPYATIKDPPVLIPKSSECGYV 1049
            GA G+DR      M K  KD  K S  +SS CSL+SSENPYATIKDPP+L  K  E  YV
Sbjct: 904  GACGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDPPILTCKLPESSYV 963

Query: 1050 EMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQGVFSNNGRLSQDPYDLPKNSHIPC 1109
            EMKSP    SPY ++ + +++N+N+YEVEPTVSVVQ    +N    Q+ YDLP+NSHIP 
Sbjct: 964  EMKSPVHMGSPYTDVPSLSTSNKNIYEVEPTVSVVQEGCGHNSSYIQNAYDLPRNSHIPG 1023

Query: 1110 HYDLLPVRDSSSSPKQED 1127
            HYDLLPVR S ++   +D
Sbjct: 1024 HYDLLPVRQSPANGPSQD 1041


>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
           sapiens]
          Length = 1037

 Score =  871 bits (2250), Expect = 0.0
 Identities = 372/732 (50%), Positives = 447/732 (61%), Gaps = 9/732 (1%)

Query: 14  LLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNW---FKCT 70
           LLL   +  A  LN  DPN CS WES++ T +ES+  PF  +    C     W     C 
Sbjct: 9   LLLAVGLRLAGTLNPSDPNTCSFWESFTTTTKESHSRPFSLLPSEPCER--PWEGPHTCP 66

Query: 71  RHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGW 130
           +  V YRT YR   KT +R++ QCC GFYES   CVP CA +CVHGRC+APN CQC PGW
Sbjct: 67  QPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGW 126

Query: 131 GGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGND 190
            G +CSS C    WGP C   C C N + C+P +G C C +G +   C   C  G YG  
Sbjct: 127 RGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPA 186

Query: 191 CHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVT 250
           C  RCQC +GA CD  TG C CP   TG  C+  C  G  G  C     CQNGGV     
Sbjct: 187 CQFRCQC-HGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQ 245

Query: 251 GECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDE 310
           G CSCP GWMGT+C  PCPEG  G NCSQEC+CHNGG CD  TGQC C+PGYTG+RC++E
Sbjct: 246 GSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREE 305

Query: 311 CPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPC 370
           CPVG +G  CAETC C    +C+  +GACLCE GF G+RC  RLCP+G YG+ C   C C
Sbjct: 306 CPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTC 365

Query: 371 HLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTC 430
             E++ SCHPM+GEC+C PGW+GL+CNE+C    +G  CQ+ C C +G  C + +G C C
Sbjct: 366 DREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQC 425

Query: 431 APGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGT 490
           APG+ G  C++ CP  TYG+NCS+RC C+N   CSP+DG C CK GW   +CS+ CP GT
Sbjct: 426 APGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGT 485

Query: 491 WGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGC 550
           WGF CN +CQC +   C+   G CTC PGW G  C+LPC  G +G  CA RCDC H+DGC
Sbjct: 486 WGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGC 545

Query: 551 HPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTT 610
            P  G C+C  GW G  C   C EG WG NCS  C CKNG +C P++G C CAPGFRG +
Sbjct: 546 DPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPS 605

Query: 611 CQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCA 670
           CQR C PG YG RC   C    HS   CH   G C CL G+TG  C++ CP G +G+NCA
Sbjct: 606 CQRSCQPGRYGKRC-VPCKCANHSF--CHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCA 662

Query: 671 GICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGE 730
             C C + GTC+P D SC C  GW G  C + CP   +G NC   C C  G  C    G 
Sbjct: 663 QTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGA 722

Query: 731 CKCTPGWTGLYC 742
           C C PG +G  C
Sbjct: 723 CVCPPGHSGAPC 734



 Score =  711 bits (1836), Expect = 0.0
 Identities = 394/1030 (38%), Positives = 491/1030 (47%), Gaps = 92/1030 (8%)

Query: 136  SSACDGDHWGPHCTSRCQCKNGALCNPITGACH-----CAAGF---RGWRCEDRCEQGTY 187
            S  C+    GPH   +       +   +    H     C  GF   RG+ C   C Q   
Sbjct: 52   SEPCERPWEGPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGF-CVPLCAQ--- 107

Query: 188  GNDC-HQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVC 246
              +C H RC   N         +C+C PG+ G  C   C PG  GPQC++ C C N   C
Sbjct: 108  --ECVHGRCVAPN---------QCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSC 156

Query: 247  HHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGER 306
               +G CSCPSG     C QPC  G +G  C   CQCH G  CD  TG C C    TG  
Sbjct: 157  DPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCH-GAPCDPQTGACFCPAERTGPS 215

Query: 307  CQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDK 366
            C   C  GT G  C  T  C NGG      G+C C  G+ G  C    CPEG +G  C +
Sbjct: 216  CDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLP-CPEGFHGPNCSQ 274

Query: 367  RCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTG 426
             C CH  N   C   +G+C C PG++G  C E C  G +G+ C + C C   A C    G
Sbjct: 275  ECRCH--NGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANG 332

Query: 427  KCTCAPGFKGIDCSTP-CPLGTYGINCSSRCGC--KNDAVCSPVDGSCTCKAGWHGVDCS 483
             C C  GF G  C+   CP G YG++C + C C  ++   C P++G C+C  GW G+ C+
Sbjct: 333  ACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCN 392

Query: 484  IRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCD 543
              CP  T G GC   C CL+GG C    G C CAPG+ G  C   C   TYG+NC+ RC 
Sbjct: 393  ESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCS 452

Query: 544  CSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECA 603
            C +A  C P  G C C  GW   +C   C  G WG +C+  C C + A CSP  G C C 
Sbjct: 453  CENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCT 512

Query: 604  PGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSG 663
            PG+ G  CQ  C  G +G  C+  C  C HS G C  + G C C  G+ GA C+  CP G
Sbjct: 513  PGWHGAHCQLPCPKGQFGEGCASRC-DCDHSDG-CDPVHGRCQCQAGWMGARCHLSCPEG 570

Query: 664  RFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAF 723
             +G NC+  CTC N GTC P + +C C PG+ G  C + C P  +G  C+  C C N +F
Sbjct: 571  LWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCV-PCKCANHSF 629

Query: 724  CSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGR 783
            C   +G C C  GWTG  C+Q CP G +G++CA  CQC +G  C    G C C  G+ G 
Sbjct: 630  CHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGH 689

Query: 784  HCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLS 843
            HC + CP GT+G  C Q C C     C   TG C C PG  GA C       +G     +
Sbjct: 690  HCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPCR------IGIQEPFT 743

Query: 844  RTSTALPADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMRVVN 903
               T  P     +GA+ GI +L  +V+ L+ALFI YRH QKGKE    AV Y+   R+  
Sbjct: 744  VMPTT-PVAYNSLGAVIGIAVLGSLVVALVALFIGYRHWQKGKEHHHLAVAYSSG-RLDG 801

Query: 904  ADYTISGTLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFVNLK 963
            ++Y +    P      + SHY++NPSYHTL+QC+ +P   N+            LF +L+
Sbjct: 802  SEYVMPDVPP------SYSHYYSNPSYHTLSQCSPNPPPPNK--------VPGPLFASLQ 847

Query: 964  NVNPGKRGPVGDCTGTLPADWKH-----GGYLNELGAFGLDRSYMGKSL--------KDL 1010
            N          D   TLPADWKH      G L+  G+  LDRSY             K L
Sbjct: 848  NPERPGGAQGHDNHTTLPADWKHRREPPPGPLDR-GSSRLDRSYSYSYSNGPGPFYNKGL 906

Query: 1011 GKNSEYNSSNCSLSSSENPYATIKDPPVLIPKSSECGYVEMKSPARRDSPYAEINNSTSA 1070
                E  +S  SL SSENPYATI+D P L     E  Y+EMK P     P        S 
Sbjct: 907  ISEEELGASVASL-SSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQFWDSQ 965

Query: 1071 NRNVYEVEPTVSVVQGVFSNNGRL--------SQDP---------YDLPKNSHIPCHYDL 1113
             R     +P      G +     L        SQ P         YD PKNSHIP HYDL
Sbjct: 966  RRR----QPQPQRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYDL 1021

Query: 1114 LPVRDSSSSP 1123
             PVR   S P
Sbjct: 1022 PPVRHPPSPP 1031


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  717 bits (1851), Expect = 0.0
 Identities = 316/758 (41%), Positives = 405/758 (53%), Gaps = 32/758 (4%)

Query: 94   CCPGFYESGEMCV---------PHCADKCVHGRCIAPNT---------CQCEPGWGGTNC 135
            C PG Y  G  C          P C+++C   +C+ P+T         C C+ G+ G  C
Sbjct: 628  CDPGLY--GRFCHLTCPPWAFGPGCSEEC---QCVQPHTQSCDKRDGSCSCKAGFRGERC 682

Query: 136  SSACDGDHWGPHCTSRCQCKNGALCNPITGAC--HCAAGFRGWRCEDRCEQGTYGNDCHQ 193
             + C+  ++GP C   C C  G  C+ ++G C   C AGF+G  C   C  GT+G +C  
Sbjct: 683  QAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSS 742

Query: 194  RCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCP-CQNGGVCHHVTGE 252
             C C  GA C  VTG+CRCPPG TG  CE  CP G+ G  C++ CP CQ+   C   TG 
Sbjct: 743  SCSC-GGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGA 801

Query: 253  CSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECP 312
            C C  G++G+ C   CP G +G +C   C C N G C  ATG C C+PG+TG  CQ  C 
Sbjct: 802  CLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACD 861

Query: 313  VGTYGVLCAETCQCVNG-GKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCH 371
             G +G  C+  C C  G G C  +SG CLCEAG+ G RCE + CP+G +G  C++RC C 
Sbjct: 862  TGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQ-CPQGHFGPGCEQRCQC- 919

Query: 372  LENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCA 431
             ++  +C  +SG C C  GW G +C   C  GF+G  C+  C+C  GA CD+V G C C 
Sbjct: 920  -QHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCP 978

Query: 432  PGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTW 491
             G +G  C+  CP  TYG NCS  C C N A C PV G C C  GW G  C   CP+G +
Sbjct: 979  AGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLY 1038

Query: 492  GFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCH 551
            G  C  +C C NGG C+ + G C C  GW G  CE  C        C     C +   C 
Sbjct: 1039 GDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCD 1098

Query: 552  PTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTC 611
            P TG C C  GW+G  C S C  G +G  C+  C C  GA+C    G C C PGF G+ C
Sbjct: 1099 PHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGC 1158

Query: 612  QRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAG 671
            ++ C PG +G  C+Q C QC   +  CH  TG C C  G+ G  C + CP GR+G  C  
Sbjct: 1159 EQACPPGSFGEDCAQMC-QCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQ 1217

Query: 672  ICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGEC 731
            +C C N G+C+    +C+C  G++G+DC+  CP   +GPNC H C C  GA C    G C
Sbjct: 1218 LCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTC 1277

Query: 732  KCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPS 791
             C PG  G+ C + CP   +G  C   C C+NG  C   +G C+C  G+ GRHCE  CP 
Sbjct: 1278 LCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPP 1337

Query: 792  GTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCD 829
            G YG  C   C C NNSTC+  TGTC C PG+ G  C+
Sbjct: 1338 GRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACE 1375



 Score =  693 bits (1788), Expect = 0.0
 Identities = 313/824 (37%), Positives = 392/824 (47%), Gaps = 100/824 (12%)

Query: 102  GEMCVPHCADKCVHGRCIAP-NTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALC 160
            G  C   C D    G C+   + C C  GW G  C+  C  D +G +C+  C C+NG  C
Sbjct: 517  GHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTC 576

Query: 161  NPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAF 220
            + +TGAC C  G  G  CED C +G YG  C ++C C N   C  + G C C PG  G F
Sbjct: 577  DSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRF 636

Query: 221  CEDLCPP---------------------------------------------GKHGPQCE 235
            C   CPP                                             G  GP C 
Sbjct: 637  CHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCW 696

Query: 236  QRCPCQNGGVCHHVTGECS--CPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAAT 293
            Q C C  G  C  V+GEC   CP+G+ G  CGQ CP G FG NCS  C C  G  C   T
Sbjct: 697  QACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSC-GGAPCHGVT 755

Query: 294  GQCHCSPGYTGERCQDECPVGTYGVLCAETC-QCVNGGKCYHVSGACLCEAGFAGERCEA 352
            GQC C PG TGE C+ +CP G +G+ C E C  C +  +C   +GACLC  GF G RC+ 
Sbjct: 756  GQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQ- 814

Query: 353  RLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQI 412
             +CP G YG  C  RC C   N   CHP +G C+C PGW+G  C   C  G +G  C   
Sbjct: 815  DVCPAGWYGPSCQTRCSC--ANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHP 872

Query: 413  CSCQNG-ADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSC 471
            C+C  G   CD+++G C C  G+ G  C   CP G +G  C  RC C++ A C  V G+C
Sbjct: 873  CNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGAC 932

Query: 472  TCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQD 531
            TC AGW G  C   CP+G +G  C   C C  G AC+ ++G+C C  G RG +C   C  
Sbjct: 933  TCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPA 992

Query: 532  GTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGA 591
             TYG NC++ C C +   C P  G C C PGW G  C   C  G +G NC   C C+NG 
Sbjct: 993  HTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGG 1052

Query: 592  SCSPDDGICECAPGFRGTTCQRICSP---------------------------------- 617
            +C P  G C C  G+ G  C++ C P                                  
Sbjct: 1053 TCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTG 1112

Query: 618  ---------GFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKN 668
                     G++G  C+Q C  C   +  CHH+TG C C PGFTG+ C + CP G FG++
Sbjct: 1113 DKCQSPCLRGWFGEACAQRC-SCPPGAA-CHHVTGACRCPPGFTGSGCEQACPPGSFGED 1170

Query: 669  CAGICTCT-NNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAY 727
            CA +C C   N  C+P   +C C  G+ G  C Q CPP  +GP C   C C NG  C A 
Sbjct: 1171 CAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAA 1230

Query: 728  DGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQ 787
             G C+C  G+ G  C   CP G +G +C  +C C  GA CD ++G C C  G  G  CE+
Sbjct: 1231 TGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCER 1290

Query: 788  KCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQA 831
             CP   +G GC   C C N   C    G+C C  GW G  C+ A
Sbjct: 1291 GCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELA 1334



 Score =  691 bits (1784), Expect = 0.0
 Identities = 314/778 (40%), Positives = 395/778 (50%), Gaps = 24/778 (3%)

Query: 93   QCCPGFYESGEMCVPHCAD------------KCVHGRCIAPNT--CQCEPGWGGTNCSSA 138
            +C PG   +GE C   C +             C H     P T  C C PG+ G+ C   
Sbjct: 759  RCPPG--RTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDV 816

Query: 139  CDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQ 198
            C    +GP C +RC C N   C+P TG C CA G+ G+ C+  C+ G +G DC   C C 
Sbjct: 817  CPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCS 876

Query: 199  NG-ATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPS 257
             G  +CD ++G C C  GY G  CE  CP G  GP CEQRC CQ+G  C HV+G C+CP+
Sbjct: 877  AGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPA 936

Query: 258  GWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYG 317
            GW GT C   CP G FG +C   C C  G  CDA  G C C  G  G RC + CP  TYG
Sbjct: 937  GWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYG 996

Query: 318  VLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHS 377
              C++ C C NG  C  V G C C  G+ G  C  + CP GLYG  C   C C  +N  +
Sbjct: 997  HNCSQACACFNGASCDPVHGQCHCAPGWMGPSC-LQACPAGLYGDNCRHSCLC--QNGGT 1053

Query: 378  CHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGI 437
            C P+SG CAC  GW+GL C + C P      C+    C NG  CD  TG+C C  G+ G 
Sbjct: 1054 CDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGD 1113

Query: 438  DCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNL 497
             C +PC  G +G  C+ RC C   A C  V G+C C  G+ G  C   CP G++G  C  
Sbjct: 1114 KCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQ 1173

Query: 498  TCQCLNGG-ACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGH 556
             CQC     AC+   GTC+CA G+ G  C+  C  G YG  C + C C +   C   TG 
Sbjct: 1174 MCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGA 1233

Query: 557  CRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICS 616
            CRC  G+ G  C+  C +GR+GPNC+  C C  GA+C P  G C C PG  G  C+R C 
Sbjct: 1234 CRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCP 1293

Query: 617  PGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCT 676
               +G  C  TC     + G CH   G C C  G+TG  C   CP GR+G  C   C+C 
Sbjct: 1294 QNRFGVGCEHTCS--CRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCH 1351

Query: 677  NNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPG 736
            NN TC P   +C+C PG+ G  C  PCPP   G  C   C C +GA C    G C C  G
Sbjct: 1352 NNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAG 1411

Query: 737  WTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGY 796
            + G +C + C  G +G+ C   C C  GA CD ++G C C  G  G  C   C  G +G 
Sbjct: 1412 FHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGP 1471

Query: 797  GCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTST-ALPADS 853
             C   CDC   + CD ++G C+C  G+ G  C + G + +    SL++ S   LPA S
Sbjct: 1472 SCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGGPLRLPENPSLAQGSAGTLPASS 1529



 Score =  664 bits (1713), Expect = 0.0
 Identities = 294/700 (42%), Positives = 361/700 (51%), Gaps = 14/700 (2%)

Query: 139  CDGDHWGPHCTSRCQ-CKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQC 197
            C  D +G  C+  C  C+NG  C      C C  G+ G  C + C   T+G +C   C C
Sbjct: 511  CLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSC 570

Query: 198  QNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPS 257
            QNG TCD VTG CRCPPG +G  CED CP G +G  C ++C C N G CH + G C C  
Sbjct: 571  QNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDP 630

Query: 258  GWMGTVCGQPCPEGRFGKNCSQECQCHNGGT--CDAATGQCHCSPGYTGERCQDECPVGT 315
            G  G  C   CP   FG  CS+ECQC    T  CD   G C C  G+ GERCQ EC +G 
Sbjct: 631  GLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGY 690

Query: 316  YGVLCAETCQCVNGGKCYHVSGAC--LCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLE 373
            +G  C + C C  G  C  VSG C   C AGF GE C  + CP G +G+ C   C C   
Sbjct: 691  FGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDC-GQECPVGTFGVNCSSSCSC--- 746

Query: 374  NTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQIC-SCQNGADCDSVTGKCTCAP 432
                CH ++G+C C PG +G  C   C  G +G  CQ+IC +CQ+ A CD  TG C C P
Sbjct: 747  GGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLP 806

Query: 433  GFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWG 492
            GF G  C   CP G YG +C +RC C ND  C P  G C+C  GW G  C   C +G WG
Sbjct: 807  GFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWG 866

Query: 493  FGCNLTCQCLNG-GACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCH 551
              C+  C C  G G+C+ + G C C  G+ G +CE  C  G +G  C +RC C H   C 
Sbjct: 867  PDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACD 926

Query: 552  PTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTC 611
              +G C C  GW G  C+  C  G +G +C   C C  GA+C   +G C C  G RG  C
Sbjct: 927  HVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRC 986

Query: 612  QRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAG 671
               C    YGH CSQ C     +   C  + G C C PG+ G  C + CP+G +G NC  
Sbjct: 987  AETCPAHTYGHNCSQAC--ACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRH 1044

Query: 672  ICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGEC 731
             C C N GTC+P+   C C  GW G  C + C P      C H+  C NG  C  + G C
Sbjct: 1045 SCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRC 1104

Query: 732  KCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPS 791
             C  GWTG  C   C  G++G+ CA  C C  GA C H++G C C  GF G  CEQ CP 
Sbjct: 1105 LCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPP 1164

Query: 792  GTYGYGCRQICDCL-NNSTCDHITGTCYCSPGWKGARCDQ 830
            G++G  C Q+C C   N  C   TGTC C+ G+ G  C Q
Sbjct: 1165 GSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQ 1204



 Score =  416 bits (1069), Expect = e-116
 Identities = 276/903 (30%), Positives = 354/903 (39%), Gaps = 179/903 (19%)

Query: 69  CTRH--RVSYRTAYRHGEKTMYRRKSQCCPGFY----ESGEMCVPHCADKCVH-GRCI-- 119
           C  H  R  Y   YR    T  R   +CC G+     E G +     A  C H GRC+  
Sbjct: 83  CVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEGCLSAECSASLCFHGGRCVPG 142

Query: 120 APNTCQCEPGWGGTNCSSACDGDHWGPHC-TSRCQCKNGALCNPITGACHCAAGFRGWRC 178
           +   C C PG+ G  C    D       C T    C++  +  P +  C C  GFR    
Sbjct: 143 SAQPCHCPPGFQGPRCQYDVD------ECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTD 196

Query: 179 EDRCEQGTYGNDCHQRCQCQNGATCDH-------VTGECRCPPGYTGAFCEDLCPPGKHG 231
              C            C   NG  C H           C+C PG+       L   G+H 
Sbjct: 197 SRTCL-------AINSCALGNGG-CQHHCVQLTITRHRCQCRPGF------QLQEDGRH- 241

Query: 232 PQCEQRCPCQN-GGVCHH----VTG--ECSCPSGWMGTVCGQPCPE-------------G 271
             C +R PC N  G C H    V G   C C  G+     G+ C +             G
Sbjct: 242 --CVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHG 299

Query: 272 RFGKNCSQECQCHNG------------------GTCDAATGQCH--CSPGYTGERCQDEC 311
                 S +C CH G                   +C+A  G C   CS    G  C   C
Sbjct: 300 CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC--TC 357

Query: 312 PVG----TYGVLCAETCQCVNGGKCYHV------SGACLCEAGFAGERCEARLCPEGLYG 361
           P G    T    C +   C +   C  V         C C AG+       RL  +G   
Sbjct: 358 PRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGY-------RLSADGCGC 410

Query: 362 IKCDKRCPCHLENTHSCHPMSG--ECACKPGWSGLYCNETCSP----------------- 402
              D+         H C  ++G  +C+C+ G+        CSP                 
Sbjct: 411 EDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRP 470

Query: 403 -----GFYGEACQQICSCQNGADCD--SVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSR 455
                    E  Q       GAD +   + G+ T    F  +D S       +G +CS  
Sbjct: 471 LPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDS-------FGHDCSLT 523

Query: 456 C-GCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTC 514
           C  C+N   C      C C  GW G+ C+  CP  T+G  C+ +C C NGG C+++ G C
Sbjct: 524 CDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGAC 583

Query: 515 TCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAE 574
            C PG  G  CE  C  G YG +C ++C+C++   CH   G C C PG  G  C   C  
Sbjct: 584 RCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPP 643

Query: 575 GRWGPNCSLPCYC--KNGASCSPDDGICECAPGFRGTTCQ-------------------- 612
             +GP CS  C C   +  SC   DG C C  GFRG  CQ                    
Sbjct: 644 WAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPV 703

Query: 613 ------------RICSPGFYGHRCSQTCP----------QCVHSSGPCHHITGLCDCLPG 650
                       + C  GF G  C Q CP           C     PCH +TG C C PG
Sbjct: 704 GVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPG 763

Query: 651 FTGALCNEVCPSGRFGKNCAGIC-TCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWG 709
            TG  C   CP GR+G  C  IC  C +   C+P   +C C PG++GS C   CP   +G
Sbjct: 764 RTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYG 823

Query: 710 PNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNG-ADCD 768
           P+C   C+C N   C    G C C PGWTG  C + C  G +G DC+  C C  G   CD
Sbjct: 824 PSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCD 883

Query: 769 HISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARC 828
            ISG C C  G++G  CEQ+CP G +G GC Q C C + + CDH++G C C  GW+G  C
Sbjct: 884 AISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFC 943

Query: 829 DQA 831
           + A
Sbjct: 944 EHA 946


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  282 bits (721), Expect = 1e-75
 Identities = 261/954 (27%), Positives = 346/954 (36%), Gaps = 301/954 (31%)

Query: 107 PHCAD--KCVHG-RCIA----PNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGAL 159
           P C D   C +G RC         C C PGW G  C    D  H GP C  R  C++  +
Sbjct: 41  PPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGP-CAGRGVCQSSVV 98

Query: 160 CNPITGACHCAAGFRGWRCE--DRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYT 217
                 +C C  GFRG  C   D C      + C    +C  G     +   C CPPGY 
Sbjct: 99  AGTARFSCRCPRGFRGPDCSLPDPC----LSSPCAHGARCSVGPDGRFL---CSCPPGYQ 151

Query: 218 GAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTG--ECSCPSGWMGTVCGQPCPEGRFGK 275
           G  C           +C    PC++GG C +  G   C CP+G+ G +C  P        
Sbjct: 152 GRSCR------SDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVP----- 200

Query: 276 NCSQECQCHNGGTCDAA---TGQCHCSPGYTGERCQ---DECP-------------VGTY 316
            C+    C NGGTC  +   T  C C PG+ G+ C+   D+CP             V TY
Sbjct: 201 -CAPS-PCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTY 258

Query: 317 GVLC------------AETCQ-----CVNGGKCYHVSG--ACLCEAGFAGERCEARL--- 354
              C             + CQ     C NGG C++  G  +C+C  G+ GE C   +   
Sbjct: 259 NCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDC 318

Query: 355 ---------------------CPEGLYGIKC--DKRC---PCHLENTHSCHPMSGECACK 388
                                CP G  G+ C  D  C   PCH +     +P++G   C 
Sbjct: 319 ATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAIC- 377

Query: 389 PGWSGLYCNETCSPGFYGEAC-QQICSCQNGAD-------CDSVTGK--CTCAPGFKGID 438
                     TC PGF G AC Q +  C  GA+       C +  G   C C  G+ G  
Sbjct: 378 ----------TCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPR 427

Query: 439 CSTPCPLGTYGINCSSRCGCKNDAVCSPVDG--SCTCKAGWHGVDCSI---RCPSGTWGF 493
           C T        +N      C+N A C    G  +C C AG+ G  C +    C S     
Sbjct: 428 CET-------DVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSS---- 476

Query: 494 GCNLTCQCLNGGAC-NTLDG-TCTCAPGWRGEKCEL--------PCQDGT--------YG 535
                  C+NGG C + ++G +CTC  G+ G  C+L        PC++G         Y 
Sbjct: 477 ------PCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYE 530

Query: 536 LNCAE-----RCDCSHADGCHPTTGH------------CRCLPGWSGVHCDSVCAEGRWG 578
             CAE      CD  + D C P   H            C C PG++G  C+S   E R  
Sbjct: 531 CRCAEGFEGTLCD-RNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQ 589

Query: 579 PNCSLPCYCKNGASCSP--DDGICECAPGFRGTTCQ------------------------ 612
           P       C++G  C    D  +C C  G  G  C+                        
Sbjct: 590 P-------CRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYD 642

Query: 613 RICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNC--- 669
            +C PGF G  C+    +C  +S PC        C+ G  G  C  +CP G     C   
Sbjct: 643 CVCQPGFTGPLCNVEINEC--ASSPCGEGG---SCVDGENGFRC--LCPPGSLPPLCLPP 695

Query: 670 AGICT--CTNNGTC--NPIDRSCQCYPGWIGSDCSQ------------------------ 701
           +  C     ++G C   P    C C PGW G  CSQ                        
Sbjct: 696 SHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMG 755

Query: 702 ---PCPPAHWGPNC--IHTCN---CHNGAFCSAYDGE---CKCTPGWTGLYCTQRCPLGF 750
               CPP   G  C  +  C    C +G  C +  G+   C C  GW G  C Q      
Sbjct: 756 FHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDV---- 811

Query: 751 YGKDCALICQCQNGADCDHISG--QCTCRTGFMGRHCEQ--------------KCPSGTY 794
              +CA    C     C +++G   CTC  G+ G  C+Q               C  G  
Sbjct: 812 --DECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVG 869

Query: 795 GYGC------------RQICDCLNN----STC-DHITG-TCYCSPGWKGARCDQ 830
            + C            R + +CL+N     TC DH+   TC C PG+ G  C+Q
Sbjct: 870 SFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQ 923



 Score =  269 bits (688), Expect = 1e-71
 Identities = 271/987 (27%), Positives = 347/987 (35%), Gaps = 312/987 (31%)

Query: 95   CPGFYESGEMCVPH--CADKCVHG-RC-IAPN---TCQCEPGWGGTNCSSACDGDHWGPH 147
            CP  +   +  +P    +  C HG RC + P+    C C PG+ G +C S  D    G  
Sbjct: 108  CPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEP 167

Query: 148  C-----------TSRCQC---------------------KNGALCNP---ITGACHCAAG 172
            C           + RCQC                     +NG  C     +T  C C  G
Sbjct: 168  CRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPG 227

Query: 173  FRGWRCEDRCEQGTYGNDCHQRCQCQNGATC-DHV-TGECRCPPGYTGAFC-EDLCPPGK 229
            F G  CE   +      DC    +C NG TC D V T  C+CPP +TG FC ED+     
Sbjct: 228  FEGQNCEVNVD------DCPGH-RCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDV----- 275

Query: 230  HGPQCE-QRCPCQNGGVCHHVTG--ECSCPSGWMGTVCGQ-------------------- 266
               +C+ Q   C NGG C +  G   C C +GW G  C Q                    
Sbjct: 276  --DECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRV 333

Query: 267  -----PCPEGRFGKNCSQE--C---QCHNGGTCDA----ATGQCHCSPGYTGERCQ---D 309
                  CP G+ G  C  +  C    CH    CD         C C PG+TG  C    D
Sbjct: 334  ASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVD 393

Query: 310  ECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAG--FAGERCEARLCPEGLYGIKCDKR 367
            EC +G           C + G+C +  G+ LC+ G  + G RCE  +  E L G      
Sbjct: 394  ECSIGAN--------PCEHLGRCVNTQGSFLCQCGRGYTGPRCETDV-NECLSG------ 438

Query: 368  CPCHLENTHSCHPMSGE--CACKPGWSGLYCNE-------------------------TC 400
             PC   N  +C    G+  C C  G++G YC                           TC
Sbjct: 439  -PCR--NQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTC 495

Query: 401  SPGFYGEACQ---QICS---CQNGADC-DSVTG-KCTCAPGFKGI-------DCSTP--- 442
              GF G  CQ     C+   C+NGA C D   G +C CA GF+G        DCS     
Sbjct: 496  PSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCH 555

Query: 443  ---CPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCS-------IRCPSGTWG 492
               C  G    +C+   G       S VD  C  +   HG  C         RCPSGT G
Sbjct: 556  HGRCVDGIASFSCACAPGYTGTRCESQVD-ECRSQPCRHGGKCLDLVDKYLCRCPSGTTG 614

Query: 493  FGCNLTCQCLNGGACN---TLDGT----CTCAPGWRGEKCELP--------------CQD 531
              C +         C      DG     C C PG+ G  C +               C D
Sbjct: 615  VNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVD 674

Query: 532  GTYGLNC--------------AERC---DCSHADGCHPTTG--HCRCLPGWSGVHCDSVC 572
            G  G  C              +  C    CSH   C+   G   C C PGWSG  C    
Sbjct: 675  GENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGI-CYDAPGGFRCVCEPGWSGPRCSQSL 733

Query: 573  AEGRWGPNCSLPCYCKNGASCSPDDGI---CECAPGFRGTTCQRI--------------- 614
            A        S PC  + G +CS  DG+   C C PG +G  C+ +               
Sbjct: 734  ARDACE---SQPC--RAGGTCS-SDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCE 787

Query: 615  ----------CSPGFYGHRCSQTCPQCVHSS-----GPCHHITGL--CDCLPGFTGALCN 657
                      C  G+ G RC Q   +C   +     G C ++ G   C C  G+TG  C+
Sbjct: 788  SAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCD 847

Query: 658  EVCPSGRFGKNCAGICTCTNNGTCNPI--DRSCQCYPGWIGSDCSQPCPPAHWGPNCIHT 715
            +         N      C N G+C       SC C PG+ G  C++        P    T
Sbjct: 848  QDI-------NDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGT 900

Query: 716  CNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADC-DHISG-Q 773
            C  H  +F       C C PG+ G +C Q  P      DC+    C NG  C D ++   
Sbjct: 901  CTDHVASFT------CTCPPGYGGFHCEQDLP------DCSP-SSCFNGGTCVDGVNSFS 947

Query: 774  CTCRTGFMGRHCEQK-------------------------CPSGTYGYGCRQICD----- 803
            C CR G+ G HC+ +                         C     G  C+ + D     
Sbjct: 948  CLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQ 1007

Query: 804  -CLNNSTCDHITGTCYCSPGWKGARCD 829
             C N   C      C C PGW G  CD
Sbjct: 1008 PCQNGGRCVQTGAYCLCPPGWSGRLCD 1034



 Score =  267 bits (683), Expect = 4e-71
 Identities = 259/887 (29%), Positives = 336/887 (37%), Gaps = 198/887 (22%)

Query: 60   CTDILNWFKCTRHR------------VSYRTAYRHGEKTMYRR---KSQCCPGFYESGEM 104
            C D +N F CT                   T  R+G K + +    + +C  GF   G +
Sbjct: 484  CKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGF--EGTL 541

Query: 105  C---VPHCA-DKCVHGRC---IAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNG 157
            C   V  C+ D C HGRC   IA  +C C PG+ GT C S  D       C S+  C++G
Sbjct: 542  CDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVD------ECRSQ-PCRHG 594

Query: 158  ALCNPITGA--CHCAAGFRGWRCE---DRCEQG--TYG--NDCHQR--CQCQNGAT---C 203
              C  +     C C +G  G  CE   D C     T+G   D   R  C CQ G T   C
Sbjct: 595  GKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLC 654

Query: 204  DHVTGECRCPPGYTGAFCED-------LCPPGKHGPQC---EQRC---PCQNGGVCHHVT 250
            +    EC   P   G  C D       LCPPG   P C      C   PC +G +C+   
Sbjct: 655  NVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAP 713

Query: 251  G--ECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTC--DAATGQCHCSPGYTGER 306
            G   C C  GW G  C Q        ++  +   C  GGTC  D     C C PG  G +
Sbjct: 714  GGFRCVCEPGWSGPRCSQS-----LARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQ 768

Query: 307  CQDECPVGTYGVLCAETCQCVNGGKCYHVSG---ACLCEAGFAGERCE------ARLCPE 357
            C+   P       C     C +GG+C    G    C C  G+ G RC+      A   P 
Sbjct: 769  CELLSP-------CTPN-PCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPC 820

Query: 358  GLYGIKCDKR----CPCHLENTH-SCHPMSGECACKPGWSGLYCNE-------TCSPGFY 405
            G +GI  +      C CH   T  SC     +C   P  +G  C +       +C PGF 
Sbjct: 821  GPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFA 880

Query: 406  GEACQQICS------CQNGADCDSVTG-KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGC 458
            G  C +         C  G   D V    CTC PG+ G  C    P      +CS    C
Sbjct: 881  GPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLP------DCSPS-SC 933

Query: 459  KNDAVCSPVDG----SCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDG-- 512
             N   C  VDG    SC C+ G+ G  C            C L+  CL+GG C+      
Sbjct: 934  FNGGTC--VDGVNSFSCLCRPGYTGAHCQHEADP------C-LSRPCLHGGVCSAAHPGF 984

Query: 513  TCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDS-- 570
             CTC   + G +C+         ++   R  C +   C  T  +C C PGWSG  CD   
Sbjct: 985  RCTCLESFTGPQCQTL-------VDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRS 1037

Query: 571  -VCAEGRWGPNCSLPCYCKNGASCSPDDG--ICECAPGFRGTTCQRICSPGFYGHRCSQT 627
              C E        L   C+ G  C  +D    C C  G  G+ C++   P          
Sbjct: 1038 LPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCL-------- 1089

Query: 628  CPQCVHSSGPCHHITG--LCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPID 685
               C H  G C    G  +C+CLPG+ G  C +          CA    C + G+C  + 
Sbjct: 1090 AQPCQHG-GTCRGYMGGYMCECLPGYNGDNCEDDVDE------CASQ-PCQHGGSCIDLV 1141

Query: 686  RS--CQCYPGWIG-------SDCSQPCPPAHWGPNCIHTCNCHN--GAFCSAYDGECKCT 734
                C C PG +G        DC  P PP   GP C+H   C +  G F       C C 
Sbjct: 1142 ARYLCSCPPGTLGVLCEINEDDCG-PGPPLDSGPRCLHNGTCVDLVGGF------RCTCP 1194

Query: 735  PGWTGLYC---TQRCPLGFYGKDCALICQCQNGADCDHISG---QCTCRTGFMGRHCE-- 786
            PG+TGL C      C  G         C   +  DC    G   +C C  GF G  C+  
Sbjct: 1195 PGYTGLRCEADINECRSG--------ACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTV 1246

Query: 787  -QKCPSGTYGYG--CRQICDCLNNSTCDHITGTCYCSPGWKGARCDQ 830
               C S    +G  CR      +      +T TC+C+  + G RC++
Sbjct: 1247 LSPCESQPCQHGGQCRP-----SPGPGGGLTFTCHCAQPFWGPRCER 1288



 Score =  262 bits (669), Expect = 2e-69
 Identities = 267/931 (28%), Positives = 333/931 (35%), Gaps = 301/931 (32%)

Query: 94   CCPGFYESGEMC---VPHC---ADKCVH-GRCIAPN---TCQCEPGWGGTNCSSACDGDH 143
            C PGF  +G  C   V  C   A+ C H GRC+       CQC  G+ G  C +  +   
Sbjct: 379  CPPGF--TGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECL 436

Query: 144  WGPHCTSRCQCKNGALCNPITG--ACHCAAGFRGWRCE---DRCEQGTYGNDCHQRCQCQ 198
             GP       C+N A C    G   C C AGF G  CE   D C          Q   C 
Sbjct: 437  SGP-------CRNQATCLDRIGQFTCICMAGFTGTYCEVDIDEC----------QSSPCV 479

Query: 199  NGATC-DHVTG-ECRCPPGYTGAFCE---DLCPPGKHGPQCEQRCPCQNGGVCHHVTG-- 251
            NG  C D V G  C CP G++G+ C+   D C             PC+NG  C       
Sbjct: 480  NGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECAS----------TPCRNGAKCVDQPDGY 529

Query: 252  ECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDA-ATGQCHCSPGYTGERCQ-- 308
            EC C  G+ GT+C +   +      CS +  CH+G   D  A+  C C+PGYTG RC+  
Sbjct: 530  ECRCAEGFEGTLCDRNVDD------CSPD-PCHHGRCVDGIASFSCACAPGYTGTRCESQ 582

Query: 309  -DECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKR 367
             DEC           +  C +GGKC  +    LC             CP G  G+ C+  
Sbjct: 583  VDEC----------RSQPCRHGGKCLDLVDKYLCR------------CPSGTTGVNCEV- 619

Query: 368  CPCHLENTHSCHPMSGECA---CKPGWSGLYCNETCSPGFYGEACQ---QICS---CQNG 418
                  N   C   S  C    C+ G +   C   C PGF G  C      C+   C  G
Sbjct: 620  ------NIDDC--ASNPCTFGVCRDGINRYDC--VCQPGFTGPLCNVEINECASSPCGEG 669

Query: 419  ADC-DSVTG-KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCK--NDAVCSPVDGS--CT 472
              C D   G +C C PG     C  P          S  C  +  +  +C    G   C 
Sbjct: 670  GSCVDGENGFRCLCPPGSLPPLCLPP----------SHPCAHEPCSHGICYDAPGGFRCV 719

Query: 473  CKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGT---CTCAPGWRGEKCEL-- 527
            C+ GW G     RC        C  +  C  GG C++ DG    CTC PG +G +CEL  
Sbjct: 720  CEPGWSGP----RCSQSLARDACE-SQPCRAGGTCSS-DGMGFHCTCPPGVQGRQCELLS 773

Query: 528  PCQDGTYGLNCAERCDCSHADGCHPTTGH---CRCLPGWSGVHC----DSVCAEGRWGPN 580
            PC              C H   C    G    C C  GW G  C    D        GP+
Sbjct: 774  PCTPNP----------CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPH 823

Query: 581  --C-----SLPCYCKNG---ASCSPDDGICECAPGFRGTTCQR-------ICSPGFYGHR 623
              C     S  C C  G    SC  D   C+  P   G +CQ         C PGF G R
Sbjct: 824  GICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPR 883

Query: 624  CSQTCPQCVHSSGPC-------HHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCT 676
            C++   +C+  S PC       H  +  C C PG+ G  C +  P      +C+   +C 
Sbjct: 884  CARDVDECL--SNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLP------DCSP-SSCF 934

Query: 677  NNGTCNPIDR----SCQCYPGWIGSDC--------SQPC------PPAH----------- 707
            N GTC  +D     SC C PG+ G+ C        S+PC        AH           
Sbjct: 935  NGGTC--VDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESF 992

Query: 708  WGPNC---IHTCN---CHNGAFCSAYDGECKCTPGWTGLYCTQR---------------- 745
             GP C   +  C+   C NG  C      C C PGW+G  C  R                
Sbjct: 993  TGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLE 1052

Query: 746  -------------------CPLGFYGKDC------ALICQCQNGADCDHISG--QCTCRT 778
                               CP G  G  C       L   CQ+G  C    G   C C  
Sbjct: 1053 QLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLP 1112

Query: 779  GFMGRHCEQ-------------------------KCPSGTYGYGCRQICD---------- 803
            G+ G +CE                           CP GT G  C    D          
Sbjct: 1113 GYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDS 1172

Query: 804  ---CLNNSTCDHITG--TCYCSPGWKGARCD 829
               CL+N TC  + G   C C PG+ G RC+
Sbjct: 1173 GPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203



 Score =  206 bits (524), Expect = 1e-52
 Identities = 188/657 (28%), Positives = 234/657 (35%), Gaps = 160/657 (24%)

Query: 224 LCPPGKHGPQCEQRCPCQNGGVCHHVTGE---CSCPSGWMGTVCG--QPCPEGRFGKNCS 278
           L  PG   P C    PC NGG C  +      C CP GW+G  C    PC  G     C+
Sbjct: 33  LAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGP----CA 88

Query: 279 QECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGA 338
               C +      A   C C  G+ G  C    P       CA   +C  G     +   
Sbjct: 89  GRGVCQSSVVAGTARFSCRCPRGFRGPDCS--LPDPCLSSPCAHGARCSVGPDGRFL--- 143

Query: 339 CLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNE 398
           C C  G+ G  C + +        +C    PC    T    P S  C C  G++G  C  
Sbjct: 144 CSCPPGYQGRSCRSDVD-------ECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCEN 196

Query: 399 TCSPGFYGEACQQICSCQNGADC---DSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSR 455
              P      C     C+NG  C     +T  C C PGF+G +C          +N    
Sbjct: 197 PAVP------CAP-SPCRNGGTCRQSGDLTYDCACLPGFEGQNCE---------VNVDDC 240

Query: 456 CG--CKNDAVCSPVDG----SCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQ-CLNGGAC- 507
            G  C N   C  VDG    +C C   W G  C+           C L    C NGG C 
Sbjct: 241 PGHRCLNGGTC--VDGVNTYNCQCPPEWTGQFCTEDVDE------CQLQPNACHNGGTCF 292

Query: 508 NTLDG-TCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTG--HCRCLPGWS 564
           NTL G +C C  GW GE C     D      CA    C H   CH      +C C  G +
Sbjct: 293 NTLGGHSCVCVNGWTGESCSQNIDD------CATAV-CFHGATCHDRVASFYCACPMGKT 345

Query: 565 GV--HCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGH 622
           G+  H D  C         S PC+         +D IC+  P      C   C PGF G 
Sbjct: 346 GLLCHLDDACV--------SNPCH---------EDAICDTNPVNGRAICT--CPPGFTGG 386

Query: 623 RCSQTCPQCVHSSGPCHHI--------TGLCDCLPGFTGALCN---EVCPSGRFGKNCAG 671
            C Q   +C   + PC H+        + LC C  G+TG  C      C SG        
Sbjct: 387 ACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSG-------- 438

Query: 672 ICTCTNNGTCNPIDR----SCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAY 727
              C N  TC  +DR    +C C  G+ G+ C          P       C NG  C   
Sbjct: 439 --PCRNQATC--LDRIGQFTCICMAGFTGTYCEVDIDECQSSP-------CVNGGVCKDR 487

Query: 728 DGECKCTPGWTGLYCTQRCPLGFYGKDCAL------ICQCQNGADC-DHISG-QCTCRTG 779
                CT           CP GF G  C L         C+NGA C D   G +C C  G
Sbjct: 488 VNGFSCT-----------CPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEG 536

Query: 780 FMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDH-------ITGTCYCSPGWKGARCD 829
           F G  C+            R + DC +   C H        + +C C+PG+ G RC+
Sbjct: 537 FEGTLCD------------RNVDDC-SPDPCHHGRCVDGIASFSCACAPGYTGTRCE 580



 Score =  201 bits (512), Expect = 3e-51
 Identities = 220/826 (26%), Positives = 263/826 (31%), Gaps = 295/826 (35%)

Query: 94   CCPGFY-ESGEMCVPHCADKCVHG-RC-IAPN---TCQCEPGWGGTNC------------ 135
            C PG      E+  P   + C HG RC  AP     C C  GW G  C            
Sbjct: 760  CPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAP 819

Query: 136  --------------SSACDGDHWGPHCTSRCQ------CKNGALCNPITGA--CHCAAGF 173
                          S  C G + GP C           C NG  C    G+  C C  GF
Sbjct: 820  CGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGF 879

Query: 174  RGWRCED------------------------RCEQGTYGNDCHQRC------QCQNGATC 203
             G RC                           C  G  G  C Q         C NG TC
Sbjct: 880  AGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTC 939

Query: 204  -DHVTG-ECRCPPGYTGAFCED-----LCPPGKHG--------------------PQCE- 235
             D V    C C PGYTGA C+      L  P  HG                    PQC+ 
Sbjct: 940  VDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQT 999

Query: 236  -----QRCPCQNGGVCHHVTGECSCPSGWMGTVC-------------------------G 265
                  R PCQNGG C      C CP GW G +C                         G
Sbjct: 1000 LVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGG 1059

Query: 266  Q----------PCPEGRFGKNCSQECQ------CHNGGTCDAATG--QCHCSPGYTGERC 307
            Q           CPEGR G +C QE        C +GGTC    G   C C PGY G+ C
Sbjct: 1060 QCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNC 1119

Query: 308  QDE-------------------------CPVGTYGVLC---AETC----------QCVNG 329
            +D+                         CP GT GVLC    + C          +C++ 
Sbjct: 1120 EDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHN 1179

Query: 330  GKCYHVSGA--CLCEAGFAGERCEARL--CPEGLYGIKCDKRCPCHLENTHSCHPMSG-- 383
            G C  + G   C C  G+ G RCEA +  C  G           CH  +T  C    G  
Sbjct: 1180 GTCVDLVGGFRCTCPPGYTGLRCEADINECRSG----------ACHAAHTRDCLQDPGGG 1229

Query: 384  -ECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADC-------DSVTGKCTCAPGFK 435
              C C  G+SG  C    SP      C+    CQ+G  C         +T  C CA  F 
Sbjct: 1230 FRCLCHAGFSGPRCQTVLSP------CES-QPCQHGGQCRPSPGPGGGLTFTCHCAQPFW 1282

Query: 436  GIDC--------STPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSI--R 485
            G  C           CP+   G+ C            +P    C C  G  G  C     
Sbjct: 1283 GPRCERVARSCRELQCPV---GVPCQQ----------TPRGPRCACPPGLSGPSCRSFPG 1329

Query: 486  CPSGTWGFGCNLTCQCLNGGACNTLD----GTCTCAPGWRGEKCELPCQDGTYGLNCAER 541
             P G     C     CL+GG+C          C CA GW G +CE P          +E 
Sbjct: 1330 SPPGASNASC-AAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAA----APEVSEE 1384

Query: 542  CDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICE 601
              C  A  C    G  R         CD  C                N   C  D G C 
Sbjct: 1385 PRCPRA-ACQAKRGDQR---------CDREC----------------NSPGCGWDGGDCS 1418

Query: 602  CAPGFRGTTCQRI-CSPGFYGHRCSQTC--PQCVHSSGPCHHITGLCDCLPGFTGALCNE 658
             + G     C+ + C   F   RC   C  P C++ +  CH          G     CN 
Sbjct: 1419 LSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCH---------AGGRERTCNP 1469

Query: 659  VCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCP 704
            V     + K CA       +G C+    + +C  GW G DC+   P
Sbjct: 1470 V-----YEKYCADHFA---DGRCDQGCNTEEC--GWDGLDCASEVP 1505



 Score =  129 bits (325), Expect = 1e-29
 Identities = 146/580 (25%), Positives = 190/580 (32%), Gaps = 208/580 (35%)

Query: 94   CCPGFYESGEMCVPHCADKCVHGRCIAPNTCQC-EPGWGGTNCSSACDGDHWGPHCT--- 149
            C PG+  +G  C  H AD C+   C+    C    PG+  T     C     GP C    
Sbjct: 950  CRPGY--TGAHC-QHEADPCLSRPCLHGGVCSAAHPGFRCT-----CLESFTGPQCQTLV 1001

Query: 150  ---SRCQCKNGALCNPITGACHCAAGFRGWRCEDR------------------------- 181
               SR  C+NG  C      C C  G+ G  C+ R                         
Sbjct: 1002 DWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQC 1061

Query: 182  ----------CEQGTYGNDCHQRCQ------CQNGATCDHVTGE--CRCPPGYTGAFCED 223
                      C +G  G+ C Q         CQ+G TC    G   C C PGY G  CED
Sbjct: 1062 VDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCED 1121

Query: 224  LCPPGKHGPQCEQRCPCQNGGVCHHVTGE--CSCPSGWMGTVCGQPCPEGRFGKNCSQEC 281
                     +C  + PCQ+GG C  +     CSCP G +G +C     +   G       
Sbjct: 1122 ------DVDECASQ-PCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGP 1174

Query: 282  QCHNGGTCDAATG--QCHCSPGYTGERCQ---DECPVGTYGVLCAETCQCVNGGKCYHVS 336
            +C + GTC    G  +C C PGYTG RC+   +EC  G         C    GG      
Sbjct: 1175 RCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGG-----G 1229

Query: 337  GACLCEAGFAGERCEARL-----------------------------CPEGLYGIKCDK- 366
              CLC AGF+G RC+  L                             C +  +G +C++ 
Sbjct: 1230 FRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERV 1289

Query: 367  -------RCPCHLENTHSCHPMSGECACKPGWSGLYCNET--CSPGFYGEACQQICSCQN 417
                   +CP  +    +  P    CAC PG SG  C       PG    +C     C +
Sbjct: 1290 ARSCRELQCPVGVPCQQT--PRGPRCACPPGLSGPSCRSFPGSPPGASNASCAA-APCLH 1346

Query: 418  GADCDSVT----GKCTCAPGFKGIDCSTP-----------CP------------------ 444
            G  C         +C CA G+ G  C  P           CP                  
Sbjct: 1347 GGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECN 1406

Query: 445  ---LGTYGINCS---------------------SRC--GCKNDA---------------V 463
                G  G +CS                     SRC   C + A                
Sbjct: 1407 SPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERT 1466

Query: 464  CSPV----------DGSC-----TCKAGWHGVDCSIRCPS 488
            C+PV          DG C     T + GW G+DC+   P+
Sbjct: 1467 CNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPA 1506


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  281 bits (720), Expect = 2e-75
 Identities = 269/954 (28%), Positives = 343/954 (35%), Gaps = 279/954 (29%)

Query: 101  SGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTS---RCQ---- 153
            +G +C  H  D C+   C   + C   P  G   C+  C   + GP C+     C     
Sbjct: 366  TGLLC--HLNDACISNPCNEGSNCDTNPVNGKAICT--CPSGYTGPACSQDVDECSLGAN 421

Query: 154  -CKNGALCNPITGA--CHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGE- 209
             C++   C    G+  C C  G+ G RCE         N+C     CQN ATC    GE 
Sbjct: 422  PCEHAGKCINTLGSFECQCLQGYTGPRCEIDV------NECVSN-PCQNDATCLDQIGEF 474

Query: 210  -CRCPPGYTGAFCE---DLCP--PGKHGPQC-----EQRCPCQNG---GVCHHVTGECSC 255
             C C PGY G  CE   D C   P  H  +C     E +C C  G    +C +   EC+ 
Sbjct: 475  QCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECAS 534

Query: 256  PSGWMGTVCGQP-------CPEGRFGKNCS---QECQ---CHNGGTCDA-ATGQCHCSPG 301
                 G  C          C EG  G +C     EC    CH G   D  AT  C C PG
Sbjct: 535  TPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPG 594

Query: 302  YTGERCQ---DECPVGTYGVLCAETCQCVNGGKCYHVSGA--CLCEAGFAGERCEARL-- 354
            YTG  C+   +EC           +  C +GG C     A  C C  G  G  CE  L  
Sbjct: 595  YTGHHCETNINEC----------SSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDD 644

Query: 355  -----CPEGLYGIKCDK-RCPCHLENTHS-CHPMSGECA---------CKPGWSGLYCNE 398
                 C  G    K D   C C    T S C+    ECA         C+ G +G  C  
Sbjct: 645  CASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCR- 703

Query: 399  TCSPGFYGEACQQICS------CQNGADCDSVTG-KCTCAPGFKGIDCSTPCPLGTYGIN 451
             C  G++   C    +      C +GA  DS+ G KC C PG+ G +C            
Sbjct: 704  -CPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDIN------NNE 756

Query: 452  CSSRCGCKNDAVCSPVDGS--CTCKAGWHGVDCSIR--------------CPSGTWGFGC 495
            C S   C N   C  +     CTC+ G+ G +C                 C     G+ C
Sbjct: 757  CESN-PCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKC 815

Query: 496  NL-------TCQ----------CLNGGACNTLDG----TCTCAPGWRGEKCELPCQDGTY 534
            N        TC+          C NGG C   +     +C C  GW+G+ CE+       
Sbjct: 816  NCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVD------ 869

Query: 535  GLNCAERCDCSHADGCHPTTG--HCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGAS 592
             +N      C H   C  T G   C C  G+SG +C++   + R  P       C NG S
Sbjct: 870  -INECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNP-------CHNGGS 921

Query: 593  CSPDDGI----CECAPGFRGTTCQR-------------------------ICSPGFYGHR 623
            C+  DGI    C+C PGFRGT C+                           C  GF G  
Sbjct: 922  CT--DGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIH 979

Query: 624  CSQTCPQCVHSS----GPCHHITGL----CDCLPGFTGALCNE----------------- 658
            C    P C  SS    G C  + G+    C C PGFTG+ C                   
Sbjct: 980  CENNTPDCTESSCFNGGTC--VDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQ 1037

Query: 659  --------VCPSGRFGKNCAGI------CTCTNNGTC--NPIDRSCQCYPGWIGSDCSQP 702
                     CP G  G NC  +        C N G C        C+C  GW G  C  P
Sbjct: 1038 DGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVP 1097

Query: 703  ---CPPA------------HWGPNCI-----HTCNC---HNGAFCSAYDGECKCTPGWTG 739
               C  A              G  C+     H C C   + G++C     EC  +P   G
Sbjct: 1098 SVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNG 1157

Query: 740  LYCTQ-------RCPLGFYGKDCA------LICQCQNGADCDHISG--QCTCRTGFMGRH 784
              CT        +C  G++G +C+      L   CQNG  C  +    +C+C  G  G H
Sbjct: 1158 ATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVH 1217

Query: 785  CEQKCPSGTYGYGCRQICD-------CLNNSTC-DHITG-TCYCSPGWKGARCD 829
            CE           C    D       C NN TC D + G +C C PG+ G RC+
Sbjct: 1218 CEINVDD------CNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCE 1265



 Score =  276 bits (707), Expect = 6e-74
 Identities = 268/992 (27%), Positives = 354/992 (35%), Gaps = 348/992 (35%)

Query: 117 RCIAPN-TC----QCEPGWGGTNCSSACDGDHWGPHCTS-----RCQCKNGALCNPITG- 165
           RC  P  TC    +CE   G   C   C G   GP C          CKN   C+ +   
Sbjct: 23  RCSQPGETCLNGGKCEAANGTEAC--VCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRR 80

Query: 166 -----ACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVT---GECRCPPGYT 217
                AC CA GF G  C    +     N       C+NG TCD +T    +CRCPPG++
Sbjct: 81  GVADYACSCALGFSGPLCLTPLDNACLTN------PCRNGGTCDLLTLTEYKCRCPPGWS 134

Query: 218 GAFCEDL------------------------CPPGKHGPQCEQ---RCP-----CQNGGV 245
           G  C+                          CPP  HGP C Q    C      C++GG 
Sbjct: 135 GKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGT 194

Query: 246 CHHVTG--ECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTC---DAATGQCHCSP 300
           CH+  G   C C +   G  C +P         CS    C NGGTC      T +C C P
Sbjct: 195 CHNEVGSYRCVCRATHTGPNCERPYVP------CSPS-PCQNGGTCRPTGDVTHECACLP 247

Query: 301 GYTGERCQ---DECP-------------VGTYGVLC------------AETCQ-----CV 327
           G+TG+ C+   D+CP             V TY   C             + CQ     C 
Sbjct: 248 GFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQ 307

Query: 328 NGGKCYHVSGA--CLCEAGFAGERCEARL------------------------CPEGLYG 361
           NGG C++  G   C+C  G+ GE C   +                        CP G  G
Sbjct: 308 NGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTG 367

Query: 362 IKC--DKRC---PCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQ---IC 413
           + C  +  C   PC+  +    +P++G+  C           TC  G+ G AC Q    C
Sbjct: 368 LLCHLNDACISNPCNEGSNCDTNPVNGKAIC-----------TCPSGYTGPACSQDVDEC 416

Query: 414 S-----CQNGADCDSVTG--KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSP 466
           S     C++   C +  G  +C C  G+ G  C          +N      C+NDA C  
Sbjct: 417 SLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE-------IDVNECVSNPCQNDATCLD 469

Query: 467 VDG--SCTCKAGWHGVDCSI-------------------------RCPSGTWGFGCN--- 496
             G   C C  G+ GV C +                          CP+G  G  C    
Sbjct: 470 QIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDV 529

Query: 497 ---LTCQCLNGGACNTLDG----TCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADG 549
               +  C NG  C  LDG    TC C  G+ G  CE+            + CD    D 
Sbjct: 530 DECASTPCKNGAKC--LDGPNTYTCVCTEGYTGTHCEVD----------IDECD---PDP 574

Query: 550 CH-------PTTGHCRCLPGWSGVHCDS-------------------------VCAEGRW 577
           CH         T  C C PG++G HC++                          C +G  
Sbjct: 575 CHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTT 634

Query: 578 GPNCSL------PCYCKNGASCSPDDGI-CECAPGFRGTTCQ--------------RICS 616
           GPNC +         C +G      DG  C C PG+ G+ C                 C 
Sbjct: 635 GPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCE 694

Query: 617 PGFYGHRCSQTCPQCVH-----------SSGPCHH------ITGL-CDCLPGFTGALC-- 656
            G  G  C   CP+  H           +S PC H      + G  CDC PG++G  C  
Sbjct: 695 DGINGFTC--RCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDI 752

Query: 657 -NEVCPSGRFGKNCAGICTCTNNGTCNPIDRS--CQCYPGWIGSDC--------SQPCPP 705
            N  C S            C N GTC  +     C C  G+ G +C        S PC  
Sbjct: 753 NNNECESN----------PCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPC-- 800

Query: 706 AHWGPNCI-----HTCNC---HNGAFCSAYDGECKCTPGWTGLYCTQR---------CPL 748
            + G  CI     + CNC   + GA C      C  +P   G  C Q          CP 
Sbjct: 801 LNQG-TCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPT 859

Query: 749 GFYGKDC------ALICQCQNGADCDHISG--QCTCRTGFMGRHCEQKCPSGTYGYGCRQ 800
           G+ G+ C       ++  C++GA C +  G  +C C+ G+ GR+CE           CR 
Sbjct: 860 GWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDD------CRP 913

Query: 801 ICDCLNNSTC-DHI-TGTCYCSPGWKGARCDQ 830
              C N  +C D I T  C C PG++G  C++
Sbjct: 914 -NPCHNGGSCTDGINTAFCDCLPGFRGTFCEE 944



 Score =  269 bits (688), Expect = 1e-71
 Identities = 266/1019 (26%), Positives = 347/1019 (34%), Gaps = 311/1019 (30%)

Query: 86   TMYRRKSQCCPGFYESGEMCV---PHCADKCVHG-RCI---APNTCQCEPGWGGTNCSS- 137
            T+   K +C PG+  SG+ C    P  ++ C +G +C+   A   C C P + G  C   
Sbjct: 121  TLTEYKCRCPPGW--SGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQD 178

Query: 138  --------------------------ACDGDHWGPHCT------SRCQCKNGALCNP--- 162
                                       C   H GP+C       S   C+NG  C P   
Sbjct: 179  VNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGD 238

Query: 163  ITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCE 222
            +T  C C  GF G  CE+  +    GN+C     C +G      T  CRCPP +TG +C 
Sbjct: 239  VTHECACLPGFTGQNCEENIDDCP-GNNCKNGGACVDGVN----TYNCRCPPEWTGQYCT 293

Query: 223  DLCPPGKHGPQCEQRCPCQNGGVCHHVTG--ECSCPSGWMGTVCGQ-------------- 266
            +     +  P       CQNGG CH+  G   C C +GW G  C +              
Sbjct: 294  EDVDECQLMPNA-----CQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGA 348

Query: 267  -----------PCPEGRFGKNC--SQEC---QCHNGGTCDA----ATGQCHCSPGYTGER 306
                        CP GR G  C  +  C    C+ G  CD         C C  GYTG  
Sbjct: 349  TCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPA 408

Query: 307  CQ---DECPVGTYGVLCAETCQCVNGGKCYHVSGA--CLCEAGFAGERCEARLCPEGLYG 361
            C    DEC +G           C + GKC +  G+  C C  G+ G RCE  +       
Sbjct: 409  CSQDVDECSLGAN--------PCEHAGKCINTLGSFECQCLQGYTGPRCEIDVN------ 454

Query: 362  IKCDKRCPCHLENTHSCHPMSGE--CACKPGWSGLYC----------------------N 397
             +C    PC  +N  +C    GE  C C PG+ G++C                      N
Sbjct: 455  -ECVSN-PC--QNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKIN 510

Query: 398  E---TCSPGFYGEACQ---QICS---CQNGADC--DSVTGKCTCAPGFKGIDCST----- 441
            E    C  GF G  CQ     C+   C+NGA C     T  C C  G+ G  C       
Sbjct: 511  EFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDEC 570

Query: 442  ---PCPLGTYGINCSS-RCGCKNDAV---CSPVDGSCTCKAGWHGVDCSIR-------CP 487
               PC  G+     ++  C C+       C      C+ +   HG  C  R       C 
Sbjct: 571  DPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL 630

Query: 488  SGTWGFGCNLTCQ------CLNGGACNTLDG-TCTCAPGWRGEKCEL------------- 527
             GT G  C +         C +G   + +DG  C C PG+ G  C +             
Sbjct: 631  KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNG 690

Query: 528  -PCQDGTYGLNC--------------AERCD---CSHADGCHPTTGH-CRCLPGWSGVHC 568
              C+DG  G  C                 C+   C H        G+ C C PGWSG +C
Sbjct: 691  GTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNC 750

Query: 569  DSVCAEGRWGPNCSLPCYCKNGASCSPDDG--ICECAPGFRGTTCQR------------- 613
            D    E    P       C NG +C       +C C  GF G  CQ              
Sbjct: 751  DINNNECESNP-------CVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQ 803

Query: 614  -ICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNE---------VCPSG 663
              C     G++C+   P   ++   C  +   C   P   G  C +         VCP+G
Sbjct: 804  GTCIDDVAGYKCNCLLP---YTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTG 860

Query: 664  RFGKNC------AGICTCTNNGTCNPIDRS--CQCYPGWIGSDCSQPCP-----PAHWGP 710
              G+ C        +  C +  +C        C C  G+ G +C          P H G 
Sbjct: 861  WQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGG 920

Query: 711  NC---IHT--CNC---HNGAFCSAYDGECKCTPGWTGLYCTQ-------RCPLGFYGKDC 755
            +C   I+T  C+C     G FC     EC   P   G  CT         CP GF G  C
Sbjct: 921  SCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHC 980

Query: 756  ------ALICQCQNGADC-DHISG-QCTCRTGFMGRHCEQK------------------- 788
                       C NG  C D I+   C C  GF G +C+                     
Sbjct: 981  ENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGC 1040

Query: 789  ------CPSGTYGYGCRQI---CD---CLNNSTC--DHITGTCYCSPGWKGARCDQAGV 833
                  CP G  G  C+ +   CD   C N   C   H    C C  GW G  CD   V
Sbjct: 1041 GSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSV 1099



 Score =  259 bits (661), Expect = 1e-68
 Identities = 249/890 (27%), Positives = 310/890 (34%), Gaps = 268/890 (30%)

Query: 110  ADKCVHGRC---IAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGA 166
            ++ CVHG C   +    C C+PGW GTNC      D     C S   C NG  C  +T  
Sbjct: 722  SNPCVHGACRDSLNGYKCDCDPGWSGTNC------DINNNECESN-PCVNGGTCKDMTSG 774

Query: 167  --CHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATC-DHVTG-ECRCPPGYTGAFCE 222
              C C  GF G  C+      T  N+C     C N  TC D V G +C C   YTGA CE
Sbjct: 775  YVCTCREGFSGPNCQ------TNINECASN-PCLNQGTCIDDVAGYKCNCLLPYTGATCE 827

Query: 223  DLCPPGKHGPQCEQRCPCQNGGVCH----HVTGECSCPSGWMGTVCGQP----------- 267
             +  P      C    PC+NGG C     + +  C CP+GW G  C              
Sbjct: 828  VVLAP------CAPS-PCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRH 880

Query: 268  --------------CPEGRFGKNCS---QECQ---CHNGGTCDAA--TGQCHCSPGYTGE 305
                          C  G  G+NC     +C+   CHNGG+C     T  C C PG+ G 
Sbjct: 881  GASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGT 940

Query: 306  RCQDE-------------------------CPVGTYGVLCAETC------QCVNGGKCYH 334
             C+++                         CP G  G+ C           C NGG C  
Sbjct: 941  FCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVD 1000

Query: 335  V--SGACLCEAGFAGERCEARL------------------------CPEGLYGIKCDK-- 366
               S  CLC  GF G  C+  +                        CP+G  G  C    
Sbjct: 1001 GINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLV 1060

Query: 367  ----RCPCHLENTHSCHPMSGE--CACKPGWSGLYCNE---TCSPGFYGEACQQICSCQN 417
                  PC  +N   C     +  C C  GW+GLYC+    +C      +       CQ+
Sbjct: 1061 HWCDSSPC--KNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQH 1118

Query: 418  GADCDSV--TGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDG--SCTC 473
            G  C     T  C C  G+ G  C          ++  S   C+N A C+   G  SC C
Sbjct: 1119 GGLCVDAGNTHHCRCQAGYTGSYCEDL-------VDECSPSPCQNGATCTDYLGGYSCKC 1171

Query: 474  KAGWHGVDCS-------------------------IRCPSGTWGFGCNLTC--------- 499
             AG+HGV+CS                           CP GT G  C +           
Sbjct: 1172 VAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDP 1231

Query: 500  -----QCLNGGACNTLDG--TCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHP 552
                 +C N G C    G  +CTC PG+ GE+CE     G      +  CD      C  
Sbjct: 1232 VSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCE-----GDVNECLSNPCDARGTQNCVQ 1286

Query: 553  TTG--HCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDG-----ICECAPG 605
                 HC C  G +G  C+SV    +  P       CKNG +C+         IC+C  G
Sbjct: 1287 RVNDFHCECRAGHTGRRCESVINGCKGKP-------CKNGGTCAVASNTARGFICKCPAG 1339

Query: 606  FRGTTCQ---RICSPGFYGHRCSQ--TCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVC 660
            F G TC+   R C       RC    TC      SGP    +  C CL  FTG  C    
Sbjct: 1340 FEGATCENDARTCG----SLRCLNGGTC-----ISGPR---SPTCLCLGPFTGPECQFPA 1387

Query: 661  PSGRFGKNCAGICTCTNNGTCNPIDRS----CQC---------------YPGWIGSDCSQ 701
             S   G N      C N GTC P   S    C C               + G  G D   
Sbjct: 1388 SSPCLGGN-----PCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPP 1442

Query: 702  PC-PPAHWGPNC-------IHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGK 753
            P    A   P C       + +  C+N A C    G+C          CTQ      Y  
Sbjct: 1443 PLIEEACELPECQEDAGNKVCSLQCNNHA-CGWDGGDCSLNFNDPWKNCTQSLQCWKYFS 1501

Query: 754  DCALICQCQN------GADCDHISGQCT------CRTGFMGRHCEQKCPS 791
            D     QC +      G DC    GQC       C+  F   HC+Q C S
Sbjct: 1502 DGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNS 1551



 Score =  200 bits (509), Expect = 6e-51
 Identities = 187/661 (28%), Positives = 241/661 (36%), Gaps = 185/661 (27%)

Query: 274 GKNCSQECQ-CHNGGTCDAATGQ--CHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGG 330
           G  CSQ  + C NGG C+AA G   C C   + G RCQD  P       C  T  C N G
Sbjct: 21  GPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNP-------CLST-PCKNAG 72

Query: 331 KCYHVSG------ACLCEAGFAGERCEARLCPEGLYGIKCDKRC---PCHLENTHSCHPM 381
            C+ V        AC C  GF+G  C   L          D  C   PC   N  +C  +
Sbjct: 73  TCHVVDRRGVADYACSCALGFSGPLCLTPL----------DNACLTNPC--RNGGTCDLL 120

Query: 382 S---GECACKPGWSGLYCNET------------------------CSPGFYGEACQQICS 414
           +    +C C PGWSG  C +                         C P F+G  C+Q  +
Sbjct: 121 TLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN 180

Query: 415 --------CQNGADCDSVTG--KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVC 464
                   C++G  C +  G  +C C     G +C  P       + CS    C+N   C
Sbjct: 181 ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPY------VPCSP-SPCQNGGTC 233

Query: 465 SP---VDGSCTCKAGWHGVDCSIR---CPSGTWGFGCNLTCQCLNGGACNTLDG----TC 514
            P   V   C C  G+ G +C      CP             C NGGAC  +DG     C
Sbjct: 234 RPTGDVTHECACLPGFTGQNCEENIDDCPGN----------NCKNGGAC--VDGVNTYNC 281

Query: 515 TCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTG--HCRCLPGWSGVHC---- 568
            C P W G+ C     +     N      C +   CH T G  +C C+ GW+G  C    
Sbjct: 282 RCPPEWTGQYCTEDVDECQLMPNA-----CQNGGTCHNTHGGYNCVCVNGWTGEDCSENI 336

Query: 569 -DSVCAEGRWGPNC-----SLPCYCKNGAS---CSPDDGICECAPGFRGTTCQR------ 613
            D   A    G  C     S  C C +G +   C  +D  C   P   G+ C        
Sbjct: 337 DDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDA-CISNPCNEGSNCDTNPVNGK 395

Query: 614 ---ICSPGFYGHRCSQTCPQCVHSSGPCHH----ITGL----CDCLPGFTGALCN---EV 659
               C  G+ G  CSQ   +C   + PC H    I  L    C CL G+TG  C      
Sbjct: 396 AICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNE 455

Query: 660 CPSGRFGKNCAGICTCTNNGTCNPIDR----SCQCYPGWIGSDCSQPCPPAHWGPNCIHT 715
           C S            C N+ TC  +D+     C C PG+ G  C          P C+H 
Sbjct: 456 CVSN----------PCQNDATC--LDQIGEFQCICMPGYEGVHCEVNTDECASSP-CLHN 502

Query: 716 CNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISG--- 772
             C +       + +C+C  G+TG  C        Y  D      C+NGA C  + G   
Sbjct: 503 GRCLD----KINEFQCECPTGFTGHLCQ-------YDVDECASTPCKNGAKC--LDGPNT 549

Query: 773 -QCTCRTGFMGRHCE---QKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARC 828
             C C  G+ G HCE    +C      YG      C +       T TC C PG+ G  C
Sbjct: 550 YTCVCTEGYTGTHCEVDIDECDPDPCHYG-----SCKDGVA----TFTCLCRPGYTGHHC 600

Query: 829 D 829
           +
Sbjct: 601 E 601



 Score =  171 bits (434), Expect = 3e-42
 Identities = 171/605 (28%), Positives = 215/605 (35%), Gaps = 134/605 (22%)

Query: 94   CCPGFYESGEMCVPHCADKCVHGRCIAPNTCQ---------CEPGWGGTNCSSACDGDHW 144
            C PGF  +G  C  H  ++C    C+   TCQ         C  G+ G NC +     HW
Sbjct: 1009 CPPGF--TGSYC-QHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLV---HW 1062

Query: 145  GPHCTSRCQCKNGALC--NPITGACHCAAGFRGWRCED---RCEQGTYGNDCHQRCQCQN 199
               C S   CKNG  C        C C +G+ G  C+     CE             CQ+
Sbjct: 1063 ---CDSS-PCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQH 1118

Query: 200  GATCDHV--TGECRCPPGYTGAFCEDL---CPPGKHGPQCEQRCPCQNGGVCHHVTGECS 254
            G  C     T  CRC  GYTG++CEDL   C P           PCQNG  C    G  S
Sbjct: 1119 GGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPS----------PCQNGATCTDYLGGYS 1168

Query: 255  CPSGWMGTVCGQPCPEGRFGKNCSQECQ------CHNGGTC--DAATGQCHCSPGYTGER 306
            C            C  G  G NCS+E        C NGGTC     T +C C  G  G  
Sbjct: 1169 C-----------KCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVH 1217

Query: 307  CQ---DEC--PVGTYGVLCAETCQCVNGGKCYHVSG--ACLCEAGFAGERCEARLCPEGL 359
            C+   D+C  PV       + + +C N G C    G  +C C  GF GERCE  +     
Sbjct: 1218 CEINVDDCNPPVDP----VSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDV--NEC 1271

Query: 360  YGIKCDKR-------------CPCHLENT-HSCHPMSGECACKPGWSGLYCNET------ 399
                CD R             C C   +T   C  +   C  KP  +G  C         
Sbjct: 1272 LSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARG 1331

Query: 400  ----CSPGFYGEACQ---QICS---CQNGADCDS--VTGKCTCAPGFKGIDCSTPCPLGT 447
                C  GF G  C+   + C    C NG  C S   +  C C   F G +C  P     
Sbjct: 1332 FICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPC 1391

Query: 448  YGINCSSRCGCKNDAVCSPVDGS----CTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLN 503
             G N      C N   C P   S    C C A ++G+ C I   S   G G ++    + 
Sbjct: 1392 LGGN-----PCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIE 1446

Query: 504  GGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGW 563
              AC   +    C      + C L C +   G +  + C  +  D     T   +C   +
Sbjct: 1447 -EACELPE----CQEDAGNKVCSLQCNNHACGWDGGD-CSLNFNDPWKNCTQSLQCWKYF 1500

Query: 564  SGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHR 623
            S  HCDS C                N A C  D   C+ A G       + C   F    
Sbjct: 1501 SDGHCDSQC----------------NSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGH 1544

Query: 624  CSQTC 628
            C Q C
Sbjct: 1545 CDQGC 1549



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 41/133 (30%), Positives = 50/133 (37%), Gaps = 22/133 (16%)

Query: 709 GPNCIHTCN-CHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADC 767
           GP C      C NG  C A +G   C  G  G +   RC       +  L   C+N   C
Sbjct: 21  GPRCSQPGETCLNGGKCEAANGTEACVCG--GAFVGPRCQ----DPNPCLSTPCKNAGTC 74

Query: 768 DHISGQ------CTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGT---CY 818
             +  +      C+C  GF G  C     +      CR      N  TCD +T T   C 
Sbjct: 75  HVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCR------NGGTCDLLTLTEYKCR 128

Query: 819 CSPGWKGARCDQA 831
           C PGW G  C QA
Sbjct: 129 CPPGWSGKSCQQA 141


>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
          Length = 4242

 Score =  281 bits (720), Expect = 2e-75
 Identities = 235/776 (30%), Positives = 286/776 (36%), Gaps = 227/776 (29%)

Query: 94  CCPGFYESGEMCVPHCADKCVHG-----RCIAPNTCQCEPGWGGTNCSSACDGD---HWG 145
           CCP   ++G           +HG     RC    TC CEPGWGG  CS   D +      
Sbjct: 125 CCPASAQAGTGQTDVRTLCSLHGVFDLSRC----TCSCEPGWGGPTCSDPTDAEIPPSSP 180

Query: 146 PHCTSRC--QCKNGALCNPITGACHCAAGFRGWRC-----------EDRCEQGTY----- 187
           P  +  C   C +   C  + G C C  G+ G  C             RC QG       
Sbjct: 181 PSASGSCPDDCNDQGRC--VRGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAG 238

Query: 188 --GNDCHQRC---QCQNGATCDHVTGECRCPPGYTGAFCE-DLCPPGKHGPQCEQRCPCQ 241
             G DC QR     C     C+   G C C PGYTG  C    CP G     C QR  C+
Sbjct: 239 FSGPDCSQRSCPRGCSQRGRCEG--GRCVCDPGYTGDDCGMRSCPRG-----CSQRGRCE 291

Query: 242 NGGVCHHVTGECSCPSGWMGTVCG-QPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSP 300
           NG         C C  G+ G  CG + CP G     CSQ  +C +G        +C C P
Sbjct: 292 NG--------RCVCNPGYTGEDCGVRSCPRG-----CSQRGRCKDG--------RCVCDP 330

Query: 301 GYTGERCQDE-CPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGL 359
           GYTGE C    CP             C  GG+C  V G C+C  G+ GE C  R CP   
Sbjct: 331 GYTGEDCGTRSCP-----------WDCGEGGRC--VDGRCVCWPGYTGEDCSTRTCPRD- 376

Query: 360 YGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGA 419
               C  R  C            GEC C  G+SG  C     PG     C Q   C++G 
Sbjct: 377 ----CRGRGRCE----------DGECICDTGYSGDDCGVRSCPG----DCNQRGRCEDG- 417

Query: 420 DCDSVTGKCTCAPGFKGIDC-STPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWH 478
                  +C C PG+ G DC S  CP      +C  R  C+N        G C C AG+ 
Sbjct: 418 -------RCVCWPGYTGTDCGSRACPR-----DCRGRGRCEN--------GVCVCNAGYS 457

Query: 479 GVDCSIR-CPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLN 537
           G DC +R CP             C   G C +  G C C PG+ G  C      G     
Sbjct: 458 GEDCGVRSCPG-----------DCRGRGRCES--GRCMCWPGYTGRDCGTRACPG----- 499

Query: 538 CAERCDCSHADGCHPTTGHCRCLPGWSGVHCDS------------------VCAEGRWGP 579
                DC     C    G C C PG++G  C S                  VC  G  G 
Sbjct: 500 -----DCRGRGRC--VDGRCVCNPGFTGEDCGSRRCPGDCRGHGLCEDGVCVCDAGYSGE 552

Query: 580 NCSL---PCYCKNGASCSPDDGICECAPGFRGTTCQR------------------ICSPG 618
           +CS    P  C+    C   DG C C  G+ G  C                    IC  G
Sbjct: 553 DCSTRSCPGGCRGRGQCL--DGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEG 610

Query: 619 FYGHRCS-QTCPQCVHSSGPCHHITGLCDCLPGFTGALC-NEVCPSGRFGKNCAGICTCT 676
           +    CS +TCP   H  G C    G C C PG+TG  C   +CP+            C 
Sbjct: 611 YVSEDCSIRTCPSNCHGRGRCEE--GRCLCDPGYTGPTCATRMCPAD-----------CR 657

Query: 677 NNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPG 736
             G C  +   C C+ G+ G DC Q  PPA   P       C     C A  G+C C  G
Sbjct: 658 GRGRC--VQGVCLCHVGYGGEDCGQEEPPASACPG-----GCGPRELCRA--GQCVCVEG 708

Query: 737 WTGLYCT-QRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPS 791
           + G  C  Q CP             C+   +C    G C C+ G+ G  C ++ P+
Sbjct: 709 FRGPDCAIQTCP-----------GDCRGRGECH--DGSCVCKDGYAGEDCGEEVPT 751



 Score =  241 bits (616), Expect = 2e-63
 Identities = 197/663 (29%), Positives = 245/663 (36%), Gaps = 188/663 (28%)

Query: 217 TGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPC-----PEG 271
           TG  C      G    Q + R  C   GV       CSC  GW G  C  P      P  
Sbjct: 122 TGGCCPASAQAGTG--QTDVRTLCSLHGVFDLSRCTCSCEPGWGGPTCSDPTDAEIPPSS 179

Query: 272 RFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQ-DECPVGTYGVLCAETCQCVNGG 330
               + S    C++ G C    G+C C PGYTG  C    CP             C   G
Sbjct: 180 PPSASGSCPDDCNDQGRC--VRGRCVCFPGYTGPSCGWPSCPG-----------DCQGRG 226

Query: 331 KCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPG 390
           +C  V G C+C AGF+G  C  R CP G     C +R  C            G C C PG
Sbjct: 227 RC--VQGVCVCRAGFSGPDCSQRSCPRG-----CSQRGRCE----------GGRCVCDPG 269

Query: 391 WSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCST-PCPLGTYG 449
           ++G  C     P      C Q   C+NG        +C C PG+ G DC    CP G   
Sbjct: 270 YTGDDCGMRSCP----RGCSQRGRCENG--------RCVCNPGYTGEDCGVRSCPRG--- 314

Query: 450 INCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIR-CPSGTWGFGCNLTCQCLNGGACN 508
             CS R  CK        DG C C  G+ G DC  R CP   W         C  GG C 
Sbjct: 315 --CSQRGRCK--------DGRCVCDPGYTGEDCGTRSCP---W--------DCGEGGRC- 352

Query: 509 TLDGTCTCAPGWRGEKC------------------ELPCQDGTYGLNCAERC---DCSHA 547
            +DG C C PG+ GE C                  E  C  G  G +C  R    DC+  
Sbjct: 353 -VDGRCVCWPGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSCPGDCNQR 411

Query: 548 DGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFR 607
             C    G C C PG++G  C S             P  C+    C  ++G+C C  G+ 
Sbjct: 412 GRCED--GRCVCWPGYTGTDCGSRAC----------PRDCRGRGRC--ENGVCVCNAGYS 457

Query: 608 GTTC------------------QRICSPGFYGHRC-SQTCPQCVHSSGPCHHITGLCDCL 648
           G  C                  + +C PG+ G  C ++ CP      G C  + G C C 
Sbjct: 458 GEDCGVRSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRC--VDGRCVCN 515

Query: 649 PGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCS-QPCPPAH 707
           PGFTG  C          + C G   C  +G C   D  C C  G+ G DCS + CP   
Sbjct: 516 PGFTGEDCGS--------RRCPG--DCRGHGLCE--DGVCVCDAGYSGEDCSTRSCPGG- 562

Query: 708 WGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYC-TQRCPLGFYGKDCALICQCQNGAD 766
                     C     C   DG C C  G++G  C  ++CP      DC+    CQ+G  
Sbjct: 563 ----------CRGRGQC--LDGRCVCEDGYSGEDCGVRQCP-----NDCSQHGVCQDGV- 604

Query: 767 CDHISGQCTCRTGFMGRHCE-QKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKG 825
                  C C  G++   C  + CPS  +G G            C+   G C C PG+ G
Sbjct: 605 -------CICWEGYVSEDCSIRTCPSNCHGRG-----------RCEE--GRCLCDPGYTG 644

Query: 826 ARC 828
             C
Sbjct: 645 PTC 647



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 28/106 (26%), Positives = 36/106 (33%), Gaps = 21/106 (19%)

Query: 731 CKCTPGWTGLYCTQRC-----PLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHC 785
           C C PGW G  C+        P        +    C +   C  + G+C C  G+ G  C
Sbjct: 156 CSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRC--VRGRCVCFPGYTGPSC 213

Query: 786 E-QKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQ 830
               CP            DC     C  + G C C  G+ G  C Q
Sbjct: 214 GWPSCPG-----------DCQGRGRC--VQGVCVCRAGFSGPDCSQ 246


>gi|33598931 scavenger receptor class F, member 1 isoform 3
           precursor [Homo sapiens]
          Length = 569

 Score =  276 bits (705), Expect = 1e-73
 Identities = 147/422 (34%), Positives = 186/422 (44%), Gaps = 60/422 (14%)

Query: 423 SVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDC 482
           S + +  C  G++  D     P+      C     C+ D VC    G C CK G+ G  C
Sbjct: 34  SPSAELQCCAGWRQKDQECTIPI------CEGPDACQKDEVCVK-PGLCRCKPGFFGAHC 86

Query: 483 SIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERC 542
           S RCP   WG  C  +C C   G C    G C C     G +CE PC  G +G     RC
Sbjct: 87  SSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHG-----RC 141

Query: 543 DCSHADGCHPTTGHCRCLPGW-------------SGVHCDS-----VCAEGRWGPNCSLP 584
           D        P TG C C PGW             +   C+      VC  G WG  CS  
Sbjct: 142 D--------PATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFR 193

Query: 585 CYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGL 644
           C C +G+ C  D G C C PG+ G  CQ+ C              +CV   G C   +G 
Sbjct: 194 CNC-HGSPCEQDSGRCACRPGWWGPECQQQC--------------ECVR--GRCSAASGE 236

Query: 645 CDCLPGFTGALCNEVCPSGRFGKNCAGIC-TCTNNGTCNPIDRSCQ-CYPGWIGSDCSQP 702
           C C PGF GA C   CP+G  G  CA  C  C +N  C+P   SC+ C PGW G+ C QP
Sbjct: 237 CTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQP 296

Query: 703 CPPAHWGPNCIHTC-NCHNGAFCSAYDGEC-KCTPGWTGLYCTQRCPLGFYGKDCALICQ 760
           C P  +G +C   C +C +G  C    G C +C PGW G  C   CP G +G+DC   C 
Sbjct: 297 CLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCP 356

Query: 761 CQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCS 820
                 CD ++G C C  G+ G  C   CP+G +G  C   C+C     C  ++G+C   
Sbjct: 357 TCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCEC-PEGLCHPVSGSCQPG 415

Query: 821 PG 822
            G
Sbjct: 416 SG 417



 Score =  272 bits (696), Expect = 1e-72
 Identities = 144/420 (34%), Positives = 186/420 (44%), Gaps = 60/420 (14%)

Query: 382 SGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCST 441
           S E  C  GW     ++ C+       C+   +CQ    C    G C C PGF G  CS+
Sbjct: 36  SAELQCCAGWRQK--DQECTIPI----CEGPDACQKDEVCVK-PGLCRCKPGFFGAHCSS 88

Query: 442 PCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQC 501
            CP   +G +C   C C     C P  G+C C+A               WG  C   C C
Sbjct: 89  RCPGQYWGPDCRESCPCHPHGQCEPATGACQCQAD-------------RWGARCEFPCAC 135

Query: 502 LNGGACNTLDGTCTCAPGWRGEKCELPCQ------------------DGTYGLNCAERCD 543
              G C+   G C C PGW    C  PCQ                   G +G  C+ RC+
Sbjct: 136 GPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCN 195

Query: 544 CSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECA 603
           C H   C   +G C C PGW             WGP C   C C  G  CS   G C C 
Sbjct: 196 C-HGSPCEQDSGRCACRPGW-------------WGPECQQQCECVRGR-CSAASGECTCP 240

Query: 604 PGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCD-CLPGFTGALCNEVCPS 662
           PGFRG  C+  C  G +G +C+ +C +C H+  PC   TG C+ C PG+ G  C + C  
Sbjct: 241 PGFRGARCELPCPAGSHGVQCAHSCGRCKHNE-PCSPDTGSCESCEPGWNGTQCQQPCLP 299

Query: 663 GRFGKNCAGICT-CTNNGTCNPIDRSCQ-CYPGWIGSDCSQPCPPAHWGPNCIHTC-NCH 719
           G FG++C   C  C +   C P    CQ C PGW+G  C  PCP   +G +C  TC  C 
Sbjct: 300 GTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCV 359

Query: 720 NGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTG 779
            G+ C    G+C C+ G+ G  C   CP GF+G +C++ C+C  G  C  +SG C   +G
Sbjct: 360 QGS-CDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGL-CHPVSGSCQPGSG 417



 Score =  271 bits (693), Expect = 3e-72
 Identities = 146/412 (35%), Positives = 192/412 (46%), Gaps = 55/412 (13%)

Query: 93  QCCPGFYESGEMC-VPHCA--DKCVHGR-CIAPNTCQCEPGWGGTNCSSACDGDHWGPHC 148
           QCC G+ +  + C +P C   D C     C+ P  C+C+PG+ G +CSS C G +WGP C
Sbjct: 40  QCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDC 99

Query: 149 TSRCQCKNGALCNPITGACHCAAGFRGWRCE-----------------DRCEQGTYGNDC 191
              C C     C P TGAC C A   G RCE                   CE G + + C
Sbjct: 100 RESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTC 159

Query: 192 HQRCQCQNGAT-CDHVTGECRCPPGYTGAFC----------------EDLCPPGKHGPQC 234
            + CQC   A  C+  TG C C PG+ G  C                   C PG  GP+C
Sbjct: 160 RRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPEC 219

Query: 235 EQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQEC-QCHNGGTCDAAT 293
           +Q+C C  G  C   +GEC+CP G+ G  C  PCP G  G  C+  C +C +   C   T
Sbjct: 220 QQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDT 278

Query: 294 GQCH-CSPGYTGERCQDECPVGTYGVLCAETC-QCVNGGKCYHVSGAC-LCEAGFAGERC 350
           G C  C PG+ G +CQ  C  GT+G  C + C  C +G  C   +G C  C+ G+ G RC
Sbjct: 279 GSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRC 338

Query: 351 EARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQ 410
           E   CP G +G  C   CP  ++   SC  ++G+C C  G+ G  CN +C  GF+G  C 
Sbjct: 339 EDP-CPTGTFGEDCGSTCPTCVQG--SCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCS 395

Query: 411 QICSCQNGADCDSVTGKCTCAPGFKGIDCS------TPCPLGTYGINCSSRC 456
             C C  G  C  V+G  +C PG    D +       P  L   G+ C + C
Sbjct: 396 VPCECPEGL-CHPVSG--SCQPGSGSRDTALIAGSLVPLLLLFLGLACCACC 444



 Score =  269 bits (688), Expect = 1e-71
 Identities = 142/398 (35%), Positives = 181/398 (45%), Gaps = 50/398 (12%)

Query: 250 TGECSCPSGWM--GTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERC 307
           + E  C +GW      C  P  EG           C     C    G C C PG+ G  C
Sbjct: 36  SAELQCCAGWRQKDQECTIPICEGPDA--------CQKDEVC-VKPGLCRCKPGFFGAHC 86

Query: 308 QDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARL------------- 354
              CP   +G  C E+C C   G+C   +GAC C+A   G RCE                
Sbjct: 87  SSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATG 146

Query: 355 ---CPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCS---------- 401
              C  G +   C + C C+      C   +G C CKPGW G  C+  C+          
Sbjct: 147 VCHCEPGWWSSTCRRPCQCNTAAAR-CEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDS 205

Query: 402 ------PGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSR 455
                 PG++G  CQQ C C  G  C + +G+CTC PGF+G  C  PCP G++G+ C+  
Sbjct: 206 GRCACRPGWWGPECQQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGVQCAHS 264

Query: 456 CG-CKNDAVCSPVDGSC-TCKAGWHGVDCSIRCPSGTWGFGCNLTC-QCLNGGACNTLDG 512
           CG CK++  CSP  GSC +C+ GW+G  C   C  GT+G  C   C  C +G AC    G
Sbjct: 265 CGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTG 324

Query: 513 TCT-CAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSV 571
            C  C PGW G +CE PC  GT+G +C   C       C   TG C C  G+ G  C++ 
Sbjct: 325 HCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNAS 384

Query: 572 CAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGT 609
           C  G  G NCS+PC C  G  C P  G C+   G R T
Sbjct: 385 CPAGFHGNNCSVPCECPEGL-CHPVSGSCQPGSGSRDT 421



 Score =  181 bits (459), Expect = 4e-45
 Identities = 94/275 (34%), Positives = 119/275 (43%), Gaps = 56/275 (20%)

Query: 581 CSLPCYCKNGASCSPDD-----GICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSS 635
           C++P  C+   +C  D+     G+C C PGF G  C   C   ++G  C ++CP   H  
Sbjct: 52  CTIPI-CEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCP--CHPH 108

Query: 636 GPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWI 695
           G C   TG C C              + R+G  C   C C  +G C+P    C C PGW 
Sbjct: 109 GQCEPATGACQC-------------QADRWGARCEFPCACGPHGRCDPATGVCHCEPGWW 155

Query: 696 GSDCSQPCP------------------PAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGW 737
            S C +PC                   P  WG  C   CNCH G+ C    G C C PGW
Sbjct: 156 SSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCH-GSPCEQDSGRCACRPGW 214

Query: 738 TGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYG 797
            G  C Q+C             +C  G  C   SG+CTC  GF G  CE  CP+G++G  
Sbjct: 215 WGPECQQQC-------------ECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGVQ 260

Query: 798 CRQICD-CLNNSTCDHITGTCY-CSPGWKGARCDQ 830
           C   C  C +N  C   TG+C  C PGW G +C Q
Sbjct: 261 CAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQ 295



 Score =  109 bits (272), Expect = 2e-23
 Identities = 59/200 (29%), Positives = 81/200 (40%), Gaps = 33/200 (16%)

Query: 669 CAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYD 728
           C G   C  +  C      C+C PG+ G+ CS  CP  +WGP+C  +C CH    C    
Sbjct: 57  CEGPDACQKDEVCVK-PGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPAT 115

Query: 729 GECKCTPGWTGLYCTQRCPLGFYGK-----------------DCALICQCQNGAD-CDHI 770
           G C+C     G  C   C  G +G+                  C   CQC   A  C+  
Sbjct: 116 GACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQA 175

Query: 771 SGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQ 830
           +G C C+ G+ GR C  +C             +C + S C+  +G C C PGW G  C Q
Sbjct: 176 TGACVCKPGWWGRRCSFRC-------------NC-HGSPCEQDSGRCACRPGWWGPECQQ 221

Query: 831 AGVIIVGNLNSLSRTSTALP 850
               + G  ++ S   T  P
Sbjct: 222 QCECVRGRCSAASGECTCPP 241



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 32/91 (35%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 745 RCPLGFYGKD--CAL-ICQCQNGADCDHIS---GQCTCRTGFMGRHCEQKCPSGTYGYGC 798
           +C  G+  KD  C + IC+  +    D +    G C C+ GF G HC  +CP   +G  C
Sbjct: 40  QCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDC 99

Query: 799 RQICDCLNNSTCDHITGTCYCSPGWKGARCD 829
           R+ C C  +  C+  TG C C     GARC+
Sbjct: 100 RESCPCHPHGQCEPATGACQCQADRWGARCE 130


>gi|33598929 scavenger receptor class F, member 1 isoform 1
           precursor [Homo sapiens]
          Length = 830

 Score =  276 bits (705), Expect = 1e-73
 Identities = 147/422 (34%), Positives = 186/422 (44%), Gaps = 60/422 (14%)

Query: 423 SVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDC 482
           S + +  C  G++  D     P+      C     C+ D VC    G C CK G+ G  C
Sbjct: 34  SPSAELQCCAGWRQKDQECTIPI------CEGPDACQKDEVCVK-PGLCRCKPGFFGAHC 86

Query: 483 SIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERC 542
           S RCP   WG  C  +C C   G C    G C C     G +CE PC  G +G     RC
Sbjct: 87  SSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHG-----RC 141

Query: 543 DCSHADGCHPTTGHCRCLPGW-------------SGVHCDS-----VCAEGRWGPNCSLP 584
           D        P TG C C PGW             +   C+      VC  G WG  CS  
Sbjct: 142 D--------PATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFR 193

Query: 585 CYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGL 644
           C C +G+ C  D G C C PG+ G  CQ+ C              +CV   G C   +G 
Sbjct: 194 CNC-HGSPCEQDSGRCACRPGWWGPECQQQC--------------ECVR--GRCSAASGE 236

Query: 645 CDCLPGFTGALCNEVCPSGRFGKNCAGIC-TCTNNGTCNPIDRSCQ-CYPGWIGSDCSQP 702
           C C PGF GA C   CP+G  G  CA  C  C +N  C+P   SC+ C PGW G+ C QP
Sbjct: 237 CTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQP 296

Query: 703 CPPAHWGPNCIHTC-NCHNGAFCSAYDGEC-KCTPGWTGLYCTQRCPLGFYGKDCALICQ 760
           C P  +G +C   C +C +G  C    G C +C PGW G  C   CP G +G+DC   C 
Sbjct: 297 CLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCP 356

Query: 761 CQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCS 820
                 CD ++G C C  G+ G  C   CP+G +G  C   C+C     C  ++G+C   
Sbjct: 357 TCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCEC-PEGLCHPVSGSCQPG 415

Query: 821 PG 822
            G
Sbjct: 416 SG 417



 Score =  272 bits (696), Expect = 1e-72
 Identities = 144/420 (34%), Positives = 186/420 (44%), Gaps = 60/420 (14%)

Query: 382 SGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCST 441
           S E  C  GW     ++ C+       C+   +CQ    C    G C C PGF G  CS+
Sbjct: 36  SAELQCCAGWRQK--DQECTIPI----CEGPDACQKDEVCVK-PGLCRCKPGFFGAHCSS 88

Query: 442 PCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQC 501
            CP   +G +C   C C     C P  G+C C+A               WG  C   C C
Sbjct: 89  RCPGQYWGPDCRESCPCHPHGQCEPATGACQCQAD-------------RWGARCEFPCAC 135

Query: 502 LNGGACNTLDGTCTCAPGWRGEKCELPCQ------------------DGTYGLNCAERCD 543
              G C+   G C C PGW    C  PCQ                   G +G  C+ RC+
Sbjct: 136 GPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCN 195

Query: 544 CSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECA 603
           C H   C   +G C C PGW             WGP C   C C  G  CS   G C C 
Sbjct: 196 C-HGSPCEQDSGRCACRPGW-------------WGPECQQQCECVRGR-CSAASGECTCP 240

Query: 604 PGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCD-CLPGFTGALCNEVCPS 662
           PGFRG  C+  C  G +G +C+ +C +C H+  PC   TG C+ C PG+ G  C + C  
Sbjct: 241 PGFRGARCELPCPAGSHGVQCAHSCGRCKHNE-PCSPDTGSCESCEPGWNGTQCQQPCLP 299

Query: 663 GRFGKNCAGICT-CTNNGTCNPIDRSCQ-CYPGWIGSDCSQPCPPAHWGPNCIHTC-NCH 719
           G FG++C   C  C +   C P    CQ C PGW+G  C  PCP   +G +C  TC  C 
Sbjct: 300 GTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCV 359

Query: 720 NGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTG 779
            G+ C    G+C C+ G+ G  C   CP GF+G +C++ C+C  G  C  +SG C   +G
Sbjct: 360 QGS-CDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGL-CHPVSGSCQPGSG 417



 Score =  271 bits (693), Expect = 3e-72
 Identities = 146/412 (35%), Positives = 192/412 (46%), Gaps = 55/412 (13%)

Query: 93  QCCPGFYESGEMC-VPHCA--DKCVHGR-CIAPNTCQCEPGWGGTNCSSACDGDHWGPHC 148
           QCC G+ +  + C +P C   D C     C+ P  C+C+PG+ G +CSS C G +WGP C
Sbjct: 40  QCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDC 99

Query: 149 TSRCQCKNGALCNPITGACHCAAGFRGWRCE-----------------DRCEQGTYGNDC 191
              C C     C P TGAC C A   G RCE                   CE G + + C
Sbjct: 100 RESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTC 159

Query: 192 HQRCQCQNGAT-CDHVTGECRCPPGYTGAFC----------------EDLCPPGKHGPQC 234
            + CQC   A  C+  TG C C PG+ G  C                   C PG  GP+C
Sbjct: 160 RRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPEC 219

Query: 235 EQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQEC-QCHNGGTCDAAT 293
           +Q+C C  G  C   +GEC+CP G+ G  C  PCP G  G  C+  C +C +   C   T
Sbjct: 220 QQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDT 278

Query: 294 GQCH-CSPGYTGERCQDECPVGTYGVLCAETC-QCVNGGKCYHVSGAC-LCEAGFAGERC 350
           G C  C PG+ G +CQ  C  GT+G  C + C  C +G  C   +G C  C+ G+ G RC
Sbjct: 279 GSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRC 338

Query: 351 EARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQ 410
           E   CP G +G  C   CP  ++   SC  ++G+C C  G+ G  CN +C  GF+G  C 
Sbjct: 339 EDP-CPTGTFGEDCGSTCPTCVQG--SCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCS 395

Query: 411 QICSCQNGADCDSVTGKCTCAPGFKGIDCS------TPCPLGTYGINCSSRC 456
             C C  G  C  V+G  +C PG    D +       P  L   G+ C + C
Sbjct: 396 VPCECPEGL-CHPVSG--SCQPGSGSRDTALIAGSLVPLLLLFLGLACCACC 444



 Score =  269 bits (688), Expect = 1e-71
 Identities = 142/398 (35%), Positives = 181/398 (45%), Gaps = 50/398 (12%)

Query: 250 TGECSCPSGWM--GTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERC 307
           + E  C +GW      C  P  EG           C     C    G C C PG+ G  C
Sbjct: 36  SAELQCCAGWRQKDQECTIPICEGPDA--------CQKDEVC-VKPGLCRCKPGFFGAHC 86

Query: 308 QDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARL------------- 354
              CP   +G  C E+C C   G+C   +GAC C+A   G RCE                
Sbjct: 87  SSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATG 146

Query: 355 ---CPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCS---------- 401
              C  G +   C + C C+      C   +G C CKPGW G  C+  C+          
Sbjct: 147 VCHCEPGWWSSTCRRPCQCNTAAAR-CEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDS 205

Query: 402 ------PGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSR 455
                 PG++G  CQQ C C  G  C + +G+CTC PGF+G  C  PCP G++G+ C+  
Sbjct: 206 GRCACRPGWWGPECQQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGVQCAHS 264

Query: 456 CG-CKNDAVCSPVDGSC-TCKAGWHGVDCSIRCPSGTWGFGCNLTC-QCLNGGACNTLDG 512
           CG CK++  CSP  GSC +C+ GW+G  C   C  GT+G  C   C  C +G AC    G
Sbjct: 265 CGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTG 324

Query: 513 TCT-CAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSV 571
            C  C PGW G +CE PC  GT+G +C   C       C   TG C C  G+ G  C++ 
Sbjct: 325 HCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNAS 384

Query: 572 CAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGT 609
           C  G  G NCS+PC C  G  C P  G C+   G R T
Sbjct: 385 CPAGFHGNNCSVPCECPEGL-CHPVSGSCQPGSGSRDT 421



 Score =  181 bits (459), Expect = 4e-45
 Identities = 94/275 (34%), Positives = 119/275 (43%), Gaps = 56/275 (20%)

Query: 581 CSLPCYCKNGASCSPDD-----GICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSS 635
           C++P  C+   +C  D+     G+C C PGF G  C   C   ++G  C ++CP   H  
Sbjct: 52  CTIPI-CEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCP--CHPH 108

Query: 636 GPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWI 695
           G C   TG C C              + R+G  C   C C  +G C+P    C C PGW 
Sbjct: 109 GQCEPATGACQC-------------QADRWGARCEFPCACGPHGRCDPATGVCHCEPGWW 155

Query: 696 GSDCSQPCP------------------PAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGW 737
            S C +PC                   P  WG  C   CNCH G+ C    G C C PGW
Sbjct: 156 SSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCH-GSPCEQDSGRCACRPGW 214

Query: 738 TGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYG 797
            G  C Q+C             +C  G  C   SG+CTC  GF G  CE  CP+G++G  
Sbjct: 215 WGPECQQQC-------------ECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGVQ 260

Query: 798 CRQICD-CLNNSTCDHITGTCY-CSPGWKGARCDQ 830
           C   C  C +N  C   TG+C  C PGW G +C Q
Sbjct: 261 CAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQ 295



 Score =  109 bits (272), Expect = 2e-23
 Identities = 59/200 (29%), Positives = 81/200 (40%), Gaps = 33/200 (16%)

Query: 669 CAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYD 728
           C G   C  +  C      C+C PG+ G+ CS  CP  +WGP+C  +C CH    C    
Sbjct: 57  CEGPDACQKDEVCVK-PGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPAT 115

Query: 729 GECKCTPGWTGLYCTQRCPLGFYGK-----------------DCALICQCQNGAD-CDHI 770
           G C+C     G  C   C  G +G+                  C   CQC   A  C+  
Sbjct: 116 GACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQA 175

Query: 771 SGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQ 830
           +G C C+ G+ GR C  +C             +C + S C+  +G C C PGW G  C Q
Sbjct: 176 TGACVCKPGWWGRRCSFRC-------------NC-HGSPCEQDSGRCACRPGWWGPECQQ 221

Query: 831 AGVIIVGNLNSLSRTSTALP 850
               + G  ++ S   T  P
Sbjct: 222 QCECVRGRCSAASGECTCPP 241



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 32/91 (35%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 745 RCPLGFYGKD--CAL-ICQCQNGADCDHIS---GQCTCRTGFMGRHCEQKCPSGTYGYGC 798
           +C  G+  KD  C + IC+  +    D +    G C C+ GF G HC  +CP   +G  C
Sbjct: 40  QCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDC 99

Query: 799 RQICDCLNNSTCDHITGTCYCSPGWKGARCD 829
           R+ C C  +  C+  TG C C     GARC+
Sbjct: 100 RESCPCHPHGQCEPATGACQCQADRWGARCE 130


>gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo
           sapiens]
          Length = 870

 Score =  275 bits (704), Expect = 1e-73
 Identities = 143/401 (35%), Positives = 180/401 (44%), Gaps = 54/401 (13%)

Query: 94  CCPGFYESGEMC---VPHCADKCVHGR-CIAPNTCQCEPGWGGTNCSSACDGDHWGPHCT 149
           CC G+ + G+ C   V      C     C+ P  C+C  G+ G NC + C    WGP C 
Sbjct: 64  CCAGWRQQGDECGIAVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCK 123

Query: 150 SRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGE 209
             C C     C  +TG C C A   G RCE               CQCQ+G TC   +G 
Sbjct: 124 ELCSCHPHGQCEDVTGQCTCHARRWGARCE-------------HACQCQHG-TCHPRSGA 169

Query: 210 CRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCP 269
           CRC PG+ GA             QC   C C     C   TG C C +GW G  C   C 
Sbjct: 170 CRCEPGWWGA-------------QCASACYCSATSRCDPQTGACLCHAGWWGRSCNNQCA 216

Query: 270 ----------------EGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPV 313
                           E  FG  C + CQC  G  C    G C C PGY G+ C++ CP 
Sbjct: 217 CNSSPCEQQSGRCQCRERTFGARCDRYCQCFRG-RCHPVDGTCACEPGYRGKYCREPCPA 275

Query: 314 GTYGVLCAETC-QCVNGGKCYHVSGACL-CEAGFAGERCEARLCPEGLYGIKCDKRCPCH 371
           G YG+ C   C QC     C    G CL CE G+ G +C+ + C  G YG  C  RCP  
Sbjct: 276 GFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCD-QPCATGFYGEGCSHRCP-P 333

Query: 372 LENTHSCHPMSGECA-CKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTC 430
             + H+C+ ++G+C  C  GW G  C   CS G YGE C  +C+      CD  +G+C C
Sbjct: 334 CRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLC 393

Query: 431 APGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSC 471
           +PG  G  C+  CP G +G +C+  C C  D  C PV G+C
Sbjct: 394 SPGVHGPHCNVTCPPGLHGADCAQACSCHED-TCDPVTGAC 433



 Score =  274 bits (701), Expect = 3e-73
 Identities = 141/412 (34%), Positives = 178/412 (43%), Gaps = 62/412 (15%)

Query: 429 TCAPGFK--GIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRC 486
           TC  G++  G +C            C     C  + VC    G C C+ G+ G +C  +C
Sbjct: 63  TCCAGWRQQGDECGIAV--------CEGNSTCSENEVCVR-PGECRCRHGYFGANCDTKC 113

Query: 487 PSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSH 546
           P   WG  C   C C   G C  + G CTC     G +CE  CQ             C H
Sbjct: 114 PRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQ-------------CQH 160

Query: 547 ADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGF 606
              CHP +G CRC PGW             WG  C+  CYC   + C P  G C C  G+
Sbjct: 161 GT-CHPRSGACRCEPGW-------------WGAQCASACYCSATSRCDPQTGACLCHAGW 206

Query: 607 RGTTCQRICSPGF----------------YGHRCSQTCPQCVHSSGPCHHITGLCDCLPG 650
            G +C   C+                   +G RC + C QC    G CH + G C C PG
Sbjct: 207 WGRSCNNQCACNSSPCEQQSGRCQCRERTFGARCDRYC-QCFR--GRCHPVDGTCACEPG 263

Query: 651 FTGALCNEVCPSGRFGKNCAGIC-TCTNNGTCNPIDRSC-QCYPGWIGSDCSQPCPPAHW 708
           + G  C E CP+G +G  C   C  C     C   +  C  C PGW G+ C QPC    +
Sbjct: 264 YRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFY 323

Query: 709 GPNCIHTCN-CHNGAFCSAYDGEC-KCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGAD 766
           G  C H C  C +G  C+   G+C +C  GW G  C  +C  G YG+DCA +C       
Sbjct: 324 GEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGH 383

Query: 767 CDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCY 818
           CD  SG+C C  G  G HC   CP G +G  C Q C C +  TCD +TG C+
Sbjct: 384 CDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSC-HEDTCDPVTGACH 434



 Score =  233 bits (593), Expect = 1e-60
 Identities = 122/375 (32%), Positives = 157/375 (41%), Gaps = 46/375 (12%)

Query: 399 TCSPGF--YGEACQQICSCQNGADCDSVT-----GKCTCAPGFKGIDCSTPCPLGTYGIN 451
           TC  G+   G+ C  I  C+  + C         G+C C  G+ G +C T CP   +G +
Sbjct: 63  TCCAGWRQQGDECG-IAVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPD 121

Query: 452 CSSRCGCKNDAVCSPVDGSCTCKAGWHGVDC----------------SIRCPSGTWGFGC 495
           C   C C     C  V G CTC A   G  C                + RC  G WG  C
Sbjct: 122 CKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCEPGWWGAQC 181

Query: 496 NLTCQCLNGGACNTLDGTCTCAPGWRGEKCE----------------LPCQDGTYGLNCA 539
              C C     C+   G C C  GW G  C                   C++ T+G  C 
Sbjct: 182 ASACYCSATSRCDPQTGACLCHAGWWGRSCNNQCACNSSPCEQQSGRCQCRERTFGARCD 241

Query: 540 ERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPC-YCKNGASCSPDDG 598
             C C     CHP  G C C PG+ G +C   C  G +G  C   C  CK    C+  +G
Sbjct: 242 RYCQCFRGR-CHPVDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEG 300

Query: 599 IC-ECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCD-CLPGFTGALC 656
            C  C PG+ GT C + C+ GFYG  CS  CP C      C+H+TG C  C  G+ G  C
Sbjct: 301 RCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPC-RDGHACNHVTGKCTRCNAGWIGDRC 359

Query: 657 NEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTC 716
              C +G +G++CA +C    +G C+     C C PG  G  C+  CPP   G +C   C
Sbjct: 360 ETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQAC 419

Query: 717 NCHNGAFCSAYDGEC 731
           +CH    C    G C
Sbjct: 420 SCHEDT-CDPVTGAC 433



 Score =  164 bits (416), Expect = 3e-40
 Identities = 89/290 (30%), Positives = 117/290 (40%), Gaps = 55/290 (18%)

Query: 565 GVHCDSVCAEGRW-GPNCSLPCYCKNGASCSPDD-----GICECAPGFRGTTCQRICSPG 618
           G    + CA  R  G  C +   C+  ++CS ++     G C C  G+ G  C   C   
Sbjct: 58  GSQVPTCCAGWRQQGDECGI-AVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQ 116

Query: 619 FYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNN 678
           F+G  C + C    H  G C  +TG C              C + R+G  C   C C  +
Sbjct: 117 FWGPDCKELCS--CHPHGQCEDVTGQC-------------TCHARRWGARCEHACQC-QH 160

Query: 679 GTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWT 738
           GTC+P   +C+C PGW             WG  C   C C   + C    G C C  GW 
Sbjct: 161 GTCHPRSGACRCEPGW-------------WGAQCASACYCSATSRCDPQTGACLCHAGWW 207

Query: 739 GLYCTQRCPLGF----------------YGKDCALICQCQNGADCDHISGQCTCRTGFMG 782
           G  C  +C                    +G  C   CQC  G  C  + G C C  G+ G
Sbjct: 208 GRSCNNQCACNSSPCEQQSGRCQCRERTFGARCDRYCQCFRGR-CHPVDGTCACEPGYRG 266

Query: 783 RHCEQKCPSGTYGYGCRQIC-DCLNNSTCDHITGTCY-CSPGWKGARCDQ 830
           ++C + CP+G YG GCR+ C  C     C    G C  C PGW G +CDQ
Sbjct: 267 KYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQ 316



 Score =  158 bits (399), Expect = 3e-38
 Identities = 80/201 (39%), Positives = 96/201 (47%), Gaps = 8/201 (3%)

Query: 102 GEMCVPHCADKCVHGRCI-APNTCQCEPGWGGTNCSSACDGDHWGPHCTSRC-QCKNGAL 159
           G  C  +C  +C  GRC     TC CEPG+ G  C   C    +G  C  RC QCK    
Sbjct: 237 GARCDRYC--QCFRGRCHPVDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQP 294

Query: 160 CNPITGAC-HCAAGFRGWRCEDRCEQGTYGNDCHQRCQ-CQNGATCDHVTGEC-RCPPGY 216
           C    G C  C  G+ G +C+  C  G YG  C  RC  C++G  C+HVTG+C RC  G+
Sbjct: 295 CTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGW 354

Query: 217 TGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKN 276
            G  CE  C  G +G  C   C     G C   +G C C  G  G  C   CP G  G +
Sbjct: 355 IGDRCETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGAD 414

Query: 277 CSQECQCHNGGTCDAATGQCH 297
           C+Q C CH   TCD  TG CH
Sbjct: 415 CAQACSCHED-TCDPVTGACH 434



 Score =  139 bits (350), Expect = 2e-32
 Identities = 77/211 (36%), Positives = 93/211 (44%), Gaps = 20/211 (9%)

Query: 53  DQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADK 112
           ++ +   C      F+   H V    A   G +  Y R+  C  GFY  G      C  +
Sbjct: 233 ERTFGARCDRYCQCFRGRCHPVDGTCACEPGYRGKYCREP-CPAGFYGLG------CRRR 285

Query: 113 CVHGRCIAPNTCQ--------CEPGWGGTNCSSACDGDHWGPHCTSRCQ-CKNGALCNPI 163
           C  G+C     C         CEPGW GT C   C    +G  C+ RC  C++G  CN +
Sbjct: 286 C--GQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHV 343

Query: 164 TGAC-HCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCE 222
           TG C  C AG+ G RCE +C  GTYG DC   C       CD  +G C C PG  G  C 
Sbjct: 344 TGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPHCN 403

Query: 223 DLCPPGKHGPQCEQRCPCQNGGVCHHVTGEC 253
             CPPG HG  C Q C C     C  VTG C
Sbjct: 404 VTCPPGLHGADCAQACSCHE-DTCDPVTGAC 433



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 40/119 (33%), Positives = 53/119 (44%), Gaps = 19/119 (15%)

Query: 718 CHNGAFCSAYD-----GECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISG 772
           C   + CS  +     GEC+C  G+ G  C  +CP  F+G DC  +C C     C+ ++G
Sbjct: 80  CEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHPHGQCEDVTG 139

Query: 773 QCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQA 831
           QCTC     G  CE  C                 + TC   +G C C PGW GA+C  A
Sbjct: 140 QCTCHARRWGARCEHACQC--------------QHGTCHPRSGACRCEPGWWGAQCASA 184



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 6/85 (7%)

Query: 752 GKDCALICQCQNGADCDHIS-----GQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLN 806
           G +C  I  C+  + C         G+C CR G+ G +C+ KCP   +G  C+++C C  
Sbjct: 72  GDECG-IAVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHP 130

Query: 807 NSTCDHITGTCYCSPGWKGARCDQA 831
           +  C+ +TG C C     GARC+ A
Sbjct: 131 HGQCEDVTGQCTCHARRWGARCEHA 155



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 31/81 (38%), Positives = 38/81 (46%), Gaps = 5/81 (6%)

Query: 89  RRKSQCCPGFYESGEMCVPHCADKCVHGRC-IAPNTCQCEPGWGGTNCSSACDGDHWGPH 147
           R +++C  G Y  GE C   CAD C  G C      C C PG  G +C+  C     G  
Sbjct: 358 RCETKCSNGTY--GEDCAFVCAD-CGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGAD 414

Query: 148 CTSRCQCKNGALCNPITGACH 168
           C   C C     C+P+TGACH
Sbjct: 415 CAQACSCHEDT-CDPVTGACH 434


>gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo
           sapiens]
          Length = 865

 Score =  275 bits (704), Expect = 1e-73
 Identities = 143/401 (35%), Positives = 180/401 (44%), Gaps = 54/401 (13%)

Query: 94  CCPGFYESGEMC---VPHCADKCVHGR-CIAPNTCQCEPGWGGTNCSSACDGDHWGPHCT 149
           CC G+ + G+ C   V      C     C+ P  C+C  G+ G NC + C    WGP C 
Sbjct: 64  CCAGWRQQGDECGIAVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCK 123

Query: 150 SRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGE 209
             C C     C  +TG C C A   G RCE               CQCQ+G TC   +G 
Sbjct: 124 ELCSCHPHGQCEDVTGQCTCHARRWGARCE-------------HACQCQHG-TCHPRSGA 169

Query: 210 CRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCP 269
           CRC PG+ GA             QC   C C     C   TG C C +GW G  C   C 
Sbjct: 170 CRCEPGWWGA-------------QCASACYCSATSRCDPQTGACLCHAGWWGRSCNNQCA 216

Query: 270 ----------------EGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPV 313
                           E  FG  C + CQC  G  C    G C C PGY G+ C++ CP 
Sbjct: 217 CNSSPCEQQSGRCQCRERTFGARCDRYCQCFRG-RCHPVDGTCACEPGYRGKYCREPCPA 275

Query: 314 GTYGVLCAETC-QCVNGGKCYHVSGACL-CEAGFAGERCEARLCPEGLYGIKCDKRCPCH 371
           G YG+ C   C QC     C    G CL CE G+ G +C+ + C  G YG  C  RCP  
Sbjct: 276 GFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCD-QPCATGFYGEGCSHRCP-P 333

Query: 372 LENTHSCHPMSGECA-CKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTC 430
             + H+C+ ++G+C  C  GW G  C   CS G YGE C  +C+      CD  +G+C C
Sbjct: 334 CRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLC 393

Query: 431 APGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSC 471
           +PG  G  C+  CP G +G +C+  C C  D  C PV G+C
Sbjct: 394 SPGVHGPHCNVTCPPGLHGADCAQACSCHED-TCDPVTGAC 433



 Score =  274 bits (701), Expect = 3e-73
 Identities = 141/412 (34%), Positives = 178/412 (43%), Gaps = 62/412 (15%)

Query: 429 TCAPGFK--GIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRC 486
           TC  G++  G +C            C     C  + VC    G C C+ G+ G +C  +C
Sbjct: 63  TCCAGWRQQGDECGIAV--------CEGNSTCSENEVCVR-PGECRCRHGYFGANCDTKC 113

Query: 487 PSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSH 546
           P   WG  C   C C   G C  + G CTC     G +CE  CQ             C H
Sbjct: 114 PRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQ-------------CQH 160

Query: 547 ADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGF 606
              CHP +G CRC PGW             WG  C+  CYC   + C P  G C C  G+
Sbjct: 161 GT-CHPRSGACRCEPGW-------------WGAQCASACYCSATSRCDPQTGACLCHAGW 206

Query: 607 RGTTCQRICSPGF----------------YGHRCSQTCPQCVHSSGPCHHITGLCDCLPG 650
            G +C   C+                   +G RC + C QC    G CH + G C C PG
Sbjct: 207 WGRSCNNQCACNSSPCEQQSGRCQCRERTFGARCDRYC-QCFR--GRCHPVDGTCACEPG 263

Query: 651 FTGALCNEVCPSGRFGKNCAGIC-TCTNNGTCNPIDRSC-QCYPGWIGSDCSQPCPPAHW 708
           + G  C E CP+G +G  C   C  C     C   +  C  C PGW G+ C QPC    +
Sbjct: 264 YRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFY 323

Query: 709 GPNCIHTCN-CHNGAFCSAYDGEC-KCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGAD 766
           G  C H C  C +G  C+   G+C +C  GW G  C  +C  G YG+DCA +C       
Sbjct: 324 GEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGH 383

Query: 767 CDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCY 818
           CD  SG+C C  G  G HC   CP G +G  C Q C C +  TCD +TG C+
Sbjct: 384 CDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSC-HEDTCDPVTGACH 434



 Score =  233 bits (593), Expect = 1e-60
 Identities = 122/375 (32%), Positives = 157/375 (41%), Gaps = 46/375 (12%)

Query: 399 TCSPGF--YGEACQQICSCQNGADCDSVT-----GKCTCAPGFKGIDCSTPCPLGTYGIN 451
           TC  G+   G+ C  I  C+  + C         G+C C  G+ G +C T CP   +G +
Sbjct: 63  TCCAGWRQQGDECG-IAVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPD 121

Query: 452 CSSRCGCKNDAVCSPVDGSCTCKAGWHGVDC----------------SIRCPSGTWGFGC 495
           C   C C     C  V G CTC A   G  C                + RC  G WG  C
Sbjct: 122 CKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCEPGWWGAQC 181

Query: 496 NLTCQCLNGGACNTLDGTCTCAPGWRGEKCE----------------LPCQDGTYGLNCA 539
              C C     C+   G C C  GW G  C                   C++ T+G  C 
Sbjct: 182 ASACYCSATSRCDPQTGACLCHAGWWGRSCNNQCACNSSPCEQQSGRCQCRERTFGARCD 241

Query: 540 ERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPC-YCKNGASCSPDDG 598
             C C     CHP  G C C PG+ G +C   C  G +G  C   C  CK    C+  +G
Sbjct: 242 RYCQCFRGR-CHPVDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEG 300

Query: 599 IC-ECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCD-CLPGFTGALC 656
            C  C PG+ GT C + C+ GFYG  CS  CP C      C+H+TG C  C  G+ G  C
Sbjct: 301 RCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPC-RDGHACNHVTGKCTRCNAGWIGDRC 359

Query: 657 NEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTC 716
              C +G +G++CA +C    +G C+     C C PG  G  C+  CPP   G +C   C
Sbjct: 360 ETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQAC 419

Query: 717 NCHNGAFCSAYDGEC 731
           +CH    C    G C
Sbjct: 420 SCHEDT-CDPVTGAC 433



 Score =  164 bits (416), Expect = 3e-40
 Identities = 89/290 (30%), Positives = 117/290 (40%), Gaps = 55/290 (18%)

Query: 565 GVHCDSVCAEGRW-GPNCSLPCYCKNGASCSPDD-----GICECAPGFRGTTCQRICSPG 618
           G    + CA  R  G  C +   C+  ++CS ++     G C C  G+ G  C   C   
Sbjct: 58  GSQVPTCCAGWRQQGDECGI-AVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQ 116

Query: 619 FYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNN 678
           F+G  C + C    H  G C  +TG C              C + R+G  C   C C  +
Sbjct: 117 FWGPDCKELCS--CHPHGQCEDVTGQC-------------TCHARRWGARCEHACQC-QH 160

Query: 679 GTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWT 738
           GTC+P   +C+C PGW             WG  C   C C   + C    G C C  GW 
Sbjct: 161 GTCHPRSGACRCEPGW-------------WGAQCASACYCSATSRCDPQTGACLCHAGWW 207

Query: 739 GLYCTQRCPLGF----------------YGKDCALICQCQNGADCDHISGQCTCRTGFMG 782
           G  C  +C                    +G  C   CQC  G  C  + G C C  G+ G
Sbjct: 208 GRSCNNQCACNSSPCEQQSGRCQCRERTFGARCDRYCQCFRGR-CHPVDGTCACEPGYRG 266

Query: 783 RHCEQKCPSGTYGYGCRQIC-DCLNNSTCDHITGTCY-CSPGWKGARCDQ 830
           ++C + CP+G YG GCR+ C  C     C    G C  C PGW G +CDQ
Sbjct: 267 KYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQ 316



 Score =  158 bits (399), Expect = 3e-38
 Identities = 80/201 (39%), Positives = 96/201 (47%), Gaps = 8/201 (3%)

Query: 102 GEMCVPHCADKCVHGRCI-APNTCQCEPGWGGTNCSSACDGDHWGPHCTSRC-QCKNGAL 159
           G  C  +C  +C  GRC     TC CEPG+ G  C   C    +G  C  RC QCK    
Sbjct: 237 GARCDRYC--QCFRGRCHPVDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQP 294

Query: 160 CNPITGAC-HCAAGFRGWRCEDRCEQGTYGNDCHQRCQ-CQNGATCDHVTGEC-RCPPGY 216
           C    G C  C  G+ G +C+  C  G YG  C  RC  C++G  C+HVTG+C RC  G+
Sbjct: 295 CTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGW 354

Query: 217 TGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKN 276
            G  CE  C  G +G  C   C     G C   +G C C  G  G  C   CP G  G +
Sbjct: 355 IGDRCETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGAD 414

Query: 277 CSQECQCHNGGTCDAATGQCH 297
           C+Q C CH   TCD  TG CH
Sbjct: 415 CAQACSCHED-TCDPVTGACH 434



 Score =  139 bits (350), Expect = 2e-32
 Identities = 77/211 (36%), Positives = 93/211 (44%), Gaps = 20/211 (9%)

Query: 53  DQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADK 112
           ++ +   C      F+   H V    A   G +  Y R+  C  GFY  G      C  +
Sbjct: 233 ERTFGARCDRYCQCFRGRCHPVDGTCACEPGYRGKYCREP-CPAGFYGLG------CRRR 285

Query: 113 CVHGRCIAPNTCQ--------CEPGWGGTNCSSACDGDHWGPHCTSRCQ-CKNGALCNPI 163
           C  G+C     C         CEPGW GT C   C    +G  C+ RC  C++G  CN +
Sbjct: 286 C--GQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHV 343

Query: 164 TGAC-HCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCE 222
           TG C  C AG+ G RCE +C  GTYG DC   C       CD  +G C C PG  G  C 
Sbjct: 344 TGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPHCN 403

Query: 223 DLCPPGKHGPQCEQRCPCQNGGVCHHVTGEC 253
             CPPG HG  C Q C C     C  VTG C
Sbjct: 404 VTCPPGLHGADCAQACSCHE-DTCDPVTGAC 433



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 40/119 (33%), Positives = 53/119 (44%), Gaps = 19/119 (15%)

Query: 718 CHNGAFCSAYD-----GECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISG 772
           C   + CS  +     GEC+C  G+ G  C  +CP  F+G DC  +C C     C+ ++G
Sbjct: 80  CEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHPHGQCEDVTG 139

Query: 773 QCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQA 831
           QCTC     G  CE  C                 + TC   +G C C PGW GA+C  A
Sbjct: 140 QCTCHARRWGARCEHACQC--------------QHGTCHPRSGACRCEPGWWGAQCASA 184



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 6/85 (7%)

Query: 752 GKDCALICQCQNGADCDHIS-----GQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLN 806
           G +C  I  C+  + C         G+C CR G+ G +C+ KCP   +G  C+++C C  
Sbjct: 72  GDECG-IAVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHP 130

Query: 807 NSTCDHITGTCYCSPGWKGARCDQA 831
           +  C+ +TG C C     GARC+ A
Sbjct: 131 HGQCEDVTGQCTCHARRWGARCEHA 155



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 31/81 (38%), Positives = 38/81 (46%), Gaps = 5/81 (6%)

Query: 89  RRKSQCCPGFYESGEMCVPHCADKCVHGRC-IAPNTCQCEPGWGGTNCSSACDGDHWGPH 147
           R +++C  G Y  GE C   CAD C  G C      C C PG  G +C+  C     G  
Sbjct: 358 RCETKCSNGTY--GEDCAFVCAD-CGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGAD 414

Query: 148 CTSRCQCKNGALCNPITGACH 168
           C   C C     C+P+TGACH
Sbjct: 415 CAQACSCHEDT-CDPVTGACH 434


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  274 bits (700), Expect = 4e-73
 Identities = 257/921 (27%), Positives = 316/921 (34%), Gaps = 265/921 (28%)

Query: 107  PHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDG-----DHWGPHCTSR-----CQC-- 154
            PHC +            C C  GWGGT+C    D         G  C  R     C C  
Sbjct: 324  PHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPP 383

Query: 155  -KNGALC-------------------NPITGA--CHCAAGFRGWRCE---DRCEQGTYGN 189
             + G LC                   NP+TG+  C C  G+ G  C    D C     G 
Sbjct: 384  GRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGP 443

Query: 190  DCHQRCQCQNGATCDHVTG--ECRCPPGYTGAFCED------------------------ 223
                   C++G +C +  G   C CPPGYTG+ CE                         
Sbjct: 444  S-----PCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFH 498

Query: 224  -LCPPGKHGPQCE------QRCPCQNGGVCHHVTG--ECSCPSGWMGTVCGQPCPEGRFG 274
             LCPPG  G  CE         PC N   CH +    +C C  G+ GT C +   E R  
Sbjct: 499  CLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECR-- 556

Query: 275  KNCSQECQCHNGGTCDAATG--QCHCSPGYTGERCQ---DECPVGTYGVLCAETCQCVNG 329
                    C NGG C    G   C C PG+ G RCQ   DEC           +  C  G
Sbjct: 557  -----SSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDEC----------LSDPCPVG 601

Query: 330  GKCYHVSGA--CLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECAC 387
              C  + GA  CLC +GF G+ CE  LC   L    C  +  C  +           C C
Sbjct: 602  ASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNL----CQPKQICKDQKD------KANCLC 651

Query: 388  KPGWSGLYCNETCSPGFYGEACQQICSCQ---NGADCDSVTGKC---------TCAPGFK 435
              G  G    E      +G   +  C C     G +C++  G C         TC P   
Sbjct: 652  PDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPS 711

Query: 436  GIDCSTPCPLGTYGINCSSRC------GCKNDAVCSPVDGS--CTCKAGWHGVDCSIRCP 487
            G +C+  CP G  G  CS          C N   C+P  G   CTC     G  C     
Sbjct: 712  GYNCT--CPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ---- 765

Query: 488  SGTWGFGCNLTCQCLNGGACNTLDGT--CTCAPGWRGEKCE---------------LPCQ 530
              T    C ++  C NGG C    GT  C CA G++G +CE                 CQ
Sbjct: 766  --TSTDYC-VSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQ 822

Query: 531  DGTYGLNCAERCDCSHADGCHPT------------------TG---HCRCLPGWSGVHCD 569
            D   G  C   C   +  G   T                  TG   HC CL GW+G  C+
Sbjct: 823  DSPQGPRCL--CPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCN 880

Query: 570  ---SVCAEGRWGPNCSLPCYCKNGASC--SPDDGICECAPGFRGTTCQR----------- 613
               S C +        +   C NG  C  S     C C PGF+G+ CQ            
Sbjct: 881  LPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQ 940

Query: 614  --------------ICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEV 659
                           C+PG+ G  CS+    C   S PCH+  G C   PG  G  C   
Sbjct: 941  NGATCMAQPSGYLCQCAPGYDGQNCSKELDAC--QSQPCHN-HGTCTPKPG--GFHC--A 993

Query: 660  CPSGRFGKNCAG--------ICTCTNNGTCNPIDRS--CQCYPGWIGSDCSQPCPPAHWG 709
            CP G  G  C G         C  T    C+ +  +  CQC PG  G  C     P H  
Sbjct: 994  CPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQ 1053

Query: 710  PNCIHTCNCHNGAFCSAYDGE-----CKCTPGWTGLYCTQRCP-LGFYGKDCALICQCQN 763
            P       C +G  C A  G      C C  G+ G  C+ R P  GF+         C +
Sbjct: 1054 P-------CFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFH--------HCHH 1098

Query: 764  GADC-----DHISGQCTCRTGFMGRHC-EQKCPSGTYGYGCRQICDCLNNSTCDHITG-- 815
            G  C          +C C +G+ G  C     P      GC     CL N +C   TG  
Sbjct: 1099 GGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPK-----GCGPPSPCLYNGSCSETTGLG 1153

Query: 816  ----TCYCSPGWKGARCDQAG 832
                 C C     G RC + G
Sbjct: 1154 GPGFRCSCPHSSPGPRCQKPG 1174



 Score =  253 bits (647), Expect = 6e-67
 Identities = 248/910 (27%), Positives = 318/910 (34%), Gaps = 274/910 (30%)

Query: 119 IAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALC--------------NPIT 164
           +   TCQC PG+ G  C        +   C +   C+NG  C              +P+T
Sbjct: 46  LGQGTCQCAPGFLGETCQ-------FPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLT 98

Query: 165 GA--CHCAAGFRGWRCEDR---------------------------CEQGTYGNDCHQR- 194
            +  C C  GF G RC+ +                           C  G  G  C  R 
Sbjct: 99  PSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRD 158

Query: 195 -CQ---CQNGATC--DHVTGECRCPPGYTGAFCED------------------------- 223
            C    C NG  C   +   +C CPPG+ G  CE                          
Sbjct: 159 FCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSF 218

Query: 224 --LCPPGKHGPQCEQR---CP---CQNGGVCHHVTGE------CSCPSGWMGTVCGQPCP 269
             LCP G+ GP+CE R   CP   C NGG C  +  +      C CP G++G  C +  P
Sbjct: 219 QCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDC-EVNP 277

Query: 270 EGRFGKNCSQECQCHNGGTCDAA--TGQCHCSPGYTGERCQ---DECPVGTYGVLCAETC 324
           +     NC    QC NGGTC     T  C C   +TG  C    DEC   T G       
Sbjct: 278 D-----NCVSH-QCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECE--TQG-----PP 324

Query: 325 QCVNGGKCYHVSGA--CLCEAGFAGERCEAR------------------------LCPEG 358
            C NGG C + +G+  C+C +G+ G  CE                          LCP G
Sbjct: 325 HCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPG 384

Query: 359 LYGIKC--DKRC---PCHLENTHSCHPMSGE--CACKPGWSGLYCNETCSPGFYGEACQQ 411
             G+ C  +  C   PCH +   S +P++G   C C+PG+SG  C++        +  Q 
Sbjct: 385 RTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQ--QG 442

Query: 412 ICSCQNGADCDSVTG--KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDG 469
              C++G  C +  G   C C PG+ G  C                    N+ +  P   
Sbjct: 443 PSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEAD----------------HNECLSQPCHP 486

Query: 470 SCTCKAGWHGVDCSIRCPSGTWGFGCNL------TCQCLNGGACNTL--DGTCTCAPGWR 521
             TC        C   CP G  G  C +      +  CLN   C+ L     C C PG+ 
Sbjct: 487 GSTCLDLLATFHC--LCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFS 544

Query: 522 GEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNC 581
           G +CE    D      CA    C    G      HC+CLPG+ G  C +   E    P  
Sbjct: 545 GTRCEEDI-DECRSSPCANGGQCQDQPGAF----HCKCLPGFEGPRCQTEVDECLSDP-- 597

Query: 582 SLPCYCKNGASC--SPDDGICECAPGFRGTTCQ-RICSPGFYGHR-------------CS 625
                C  GASC   P    C C  GF G  C+  +C+P     +             C 
Sbjct: 598 -----CPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCP 652

Query: 626 QTCPQCV--HSSGPCHH---ITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGT 680
              P C     +  CHH       C C  G+TG  C         G  C     C + GT
Sbjct: 653 DGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPEC-----EAELG-GCIS-APCAHGGT 705

Query: 681 C--NPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDG--ECKCTPG 736
           C   P   +C C  G+ G  CS+     H GP       C NG  C+   G   C C P 
Sbjct: 706 CYPQPSGYNCTCPTGYTGPTCSEEMTACHSGP-------CLNGGSCNPSPGGYYCTCPPS 758

Query: 737 WTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISG--QCTCRTGFMGRHCEQK------ 788
            TG  C           D  +   C NG  C +  G   C C  GF G  CE K      
Sbjct: 759 HTGPQCQT-------STDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCA 811

Query: 789 --------------------CPSGTYGYGCRQICD------CLNNSTCDHITGT---CYC 819
                               CP+G  G  C+ + D      C  NS C   TG    C C
Sbjct: 812 DSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQ-TGPSFHCLC 870

Query: 820 SPGWKGARCD 829
             GW G  C+
Sbjct: 871 LQGWTGPLCN 880



 Score =  229 bits (583), Expect = 1e-59
 Identities = 240/849 (28%), Positives = 307/849 (36%), Gaps = 203/849 (23%)

Query: 57   YTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHG 116
            +  C D+LN F+C                        C PGF  SG  C     D+C   
Sbjct: 525  HADCHDLLNGFQCI-----------------------CLPGF--SGTRC-EEDIDECRSS 558

Query: 117  RCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQ------CKNGALCNPITGA--CH 168
             C     CQ +PG     C    +    GP C +         C  GA C  + GA  C 
Sbjct: 559  PCANGGQCQDQPGAFHCKCLPGFE----GPRCQTEVDECLSDPCPVGASCLDLPGAFFCL 614

Query: 169  CAAGFRGWRCE------DRCEQGTYGNDCHQR--CQCQNGAT-CDHVTGECRCPPGYTGA 219
            C +GF G  CE      + C+      D   +  C C +G+  C      C C  G+   
Sbjct: 615  CPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQR 674

Query: 220  FCEDLCPPGKHGPQCEQR------CPCQNGGVCHHVTG--ECSCPSGWMGTVCGQPCPEG 271
                +C  G  GP+CE         PC +GG C+       C+CP+G+ G  C +     
Sbjct: 675  -SSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTAC 733

Query: 272  RFGKNCSQECQCHNGGTCDAATG--QCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNG 329
              G        C NGG+C+ + G   C C P +TG +CQ      T    C  +  C NG
Sbjct: 734  HSG-------PCLNGGSCNPSPGGYYCTCPPSHTGPQCQ------TSTDYCV-SAPCFNG 779

Query: 330  GKCYHVSG--ACLCEAGFAGERCEAR-------------------------LCPEGLYGI 362
            G C +  G  +CLC  GF G RCE +                         LCP G  G 
Sbjct: 780  GTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGG 839

Query: 363  KC--------DKRCPCHLENTHSCHP-MSGECACKPGWSGLYCN---ETCSPGFYGEACQ 410
             C         K CP    N+H      S  C C  GW+G  CN    +C      +   
Sbjct: 840  SCQTLMDLCAQKPCP---RNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGID 896

Query: 411  QICSCQNGADC--DSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVC--SP 466
                C NG  C     +  C C PGF+G  C        +   C SR  C+N A C   P
Sbjct: 897  VSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQ------DHVNPCESR-PCQNGATCMAQP 949

Query: 467  VDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQ---CLNGGACNTLDG--TCTCAPGWR 521
                C C  G+ G +CS    +          CQ   C N G C    G   C C PG+ 
Sbjct: 950  SGYLCQCAPGYDGQNCSKELDA----------CQSQPCHNHGTCTPKPGGFHCACPPGFV 999

Query: 522  GEKCELPCQDGTYGLNCAERCDCSHADGCHPTTG--HCRCLPGWSGVHCDSVCAEGRWGP 579
            G +CE     G       + C  +    CH      +C+CLPG +G  C     E    P
Sbjct: 1000 GLRCE-----GDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWC-----EVEIDP 1049

Query: 580  NCSLPCYCKNGASC-----SPDDGICECAPGFRGTTC-QRICSPGFYGHRCSQTCPQCVH 633
              S PC+  +G +C     SP   IC C  GF G TC  R  S GF  H C      C+ 
Sbjct: 1050 CHSQPCF--HGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGF--HHCHHG-GLCLP 1104

Query: 634  SSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPG 693
            S  P       C CL G+ G  C  + P     K C     C  NG+C+          G
Sbjct: 1105 SPKP--GFPPRCACLSGYGGPDC--LTPPA--PKGCGPPSPCLYNGSCSETTGL-----G 1153

Query: 694  WIGSDCSQPCPPAHWGPNC----IHTCNCHNG-----AFCSAYDGEC---KCTPG----W 737
              G  CS  CP +  GP C       C   +G     A CS   G      C+ G    W
Sbjct: 1154 GPGFRCS--CPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPW 1211

Query: 738  TGLYCTQRCPLGFYGKDCALICQCQ----NGADCDHISGQCT------CRTGFMGRHCEQ 787
             G     RC L F    C   C  +    +G DC+     CT      C   F   HCE+
Sbjct: 1212 KGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCE-TPPACTPAYDQYCHDHFHNGHCEK 1270

Query: 788  KCPSGTYGY 796
             C +   G+
Sbjct: 1271 GCNTAECGW 1279



 Score =  205 bits (522), Expect = 2e-52
 Identities = 227/841 (26%), Positives = 280/841 (33%), Gaps = 268/841 (31%)

Query: 94   CCPGFYESGEMCVPHCADKCVHGRCIAPNTCQ---------CEPGWGGTNCSSACDGDHW 144
            C PG    G++C     ++C    C+    C          C PG+ GT C    D    
Sbjct: 501  CPPGL--EGQLCEVE-TNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRS 557

Query: 145  GPHCTSRCQCKNGALCNPITGA--CHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGAT 202
             P       C NG  C    GA  C C  GF G RC+      T  ++C     C  GA+
Sbjct: 558  SP-------CANGGQCQDQPGAFHCKCLPGFEGPRCQ------TEVDECLSD-PCPVGAS 603

Query: 203  CDHVTGE--CRCPPGYTGAFCE-DLCPPGKHGPQ--CEQR-----CPCQNGG-------- 244
            C  + G   C CP G+TG  CE  LC P    P+  C+ +     C C +G         
Sbjct: 604  CLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPED 663

Query: 245  --VCHH---VTGECSCPSGWMGTVCG-------------------QP------CPEGRFG 274
               CHH       C C  GW G  C                    QP      CP G  G
Sbjct: 664  NCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTG 723

Query: 275  KNCSQECQ------CHNGGTCDAATG--QCHCSPGYTGERCQDECPVGTYGVLCAETCQC 326
              CS+E        C NGG+C+ + G   C C P +TG +CQ      T    C  +  C
Sbjct: 724  PTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ------TSTDYCV-SAPC 776

Query: 327  VNGGKCYHVSG--ACLCEAGFAGERCEARL-------------------------CPEGL 359
             NGG C +  G  +CLC  GF G RCE +L                         CP G 
Sbjct: 777  FNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGY 836

Query: 360  YGIKCD--------KRCPCHLENTHSCHP-MSGECACKPGWSGLYCNET----------- 399
             G  C         K CP    N+H      S  C C  GW+G  CN             
Sbjct: 837  TGGSCQTLMDLCAQKPCP---RNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQ 893

Query: 400  ------------------------CSPGFYGEACQQICS------CQNGADCDSVTGK-- 427
                                    C PGF G  CQ   +      CQNGA C +      
Sbjct: 894  GIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYL 953

Query: 428  CTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGS--CTCKAGWHGVDCS-- 483
            C CAPG+ G +CS           C S+  C N   C+P  G   C C  G+ G+ C   
Sbjct: 954  CQCAPGYDGQNCSKELDA------CQSQ-PCHNHGTCTPKPGGFHCACPPGFVGLRCEGD 1006

Query: 484  -IRC------PSGTWGFGCN-----LTCQCLNGGA---CNTLDGTCTCAPGWRGEKCELP 528
               C      P+GT    C+       CQCL G     C      C   P + G  CE  
Sbjct: 1007 VDECLDQPCHPTGT--AACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEAT 1064

Query: 529  ----------CQDGTYGLNCAERCD------CSHADGCHPTTG-----HCRCLPGWSGVH 567
                      C  G  G  C+ R        C H   C P+        C CL G+ G  
Sbjct: 1065 AGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPD 1124

Query: 568  CDSVCAEGRWGPNCSLPCYCKNGASCSPDDGI------CECAPGFRGTTCQRICSPGFYG 621
            C +  A    GP    P  C    SCS   G+      C C     G  CQ+  + G  G
Sbjct: 1125 CLTPPAPKGCGP----PSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEG 1180

Query: 622  HRCSQTCPQCVHSSGPCHHITGLCDCLPG-----------------FTGALCNEVCPSGR 664
                  C      SGP  +  G  DC  G                 F    C+  C S  
Sbjct: 1181 RSGDGACD--AGCSGPGGNWDG-GDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEE 1237

Query: 665  F---GKNCAGICTCT-----------NNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGP 710
                G +C     CT           +NG C     + +C  GW G DC        WGP
Sbjct: 1238 CLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAEC--GWDGGDCRPEDGDPEWGP 1295

Query: 711  N 711
            +
Sbjct: 1296 S 1296



 Score =  186 bits (471), Expect = 1e-46
 Identities = 169/612 (27%), Positives = 218/612 (35%), Gaps = 152/612 (24%)

Query: 95   CPGFYESGEMCVPHCADK---CVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHC--- 148
            CP  Y       P C+++   C  G C+  N   C P  GG  C+  C   H GP C   
Sbjct: 717  CPTGYTG-----PTCSEEMTACHSGPCL--NGGSCNPSPGGYYCT--CPPSHTGPQCQTS 767

Query: 149  TSRC---QCKNGALC--NPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATC 203
            T  C    C NG  C   P T +C CA GF+G RCE +       + C  R  CQ+    
Sbjct: 768  TDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQG 827

Query: 204  DHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTV 263
                  C CP GYTG  C+ L       P C +   C   G   H    C C  GW G +
Sbjct: 828  PR----CLCPTGYTGGSCQTLMDLCAQKP-CPRNSHCLQTGPSFH----CLCLQGWTGPL 878

Query: 264  CGQP---CPEGRFGKNCSQECQCHNGGTC--DAATGQCHCSPGYTGERCQDECPVGTYGV 318
            C  P   C +    +       CHNGG C     +  CHC PG+ G  CQD        V
Sbjct: 879  CNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDH-------V 931

Query: 319  LCAETCQCVNGGKCY-HVSG-ACLCEAGFAGERCEARL---------------------- 354
               E+  C NG  C    SG  C C  G+ G+ C   L                      
Sbjct: 932  NPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFH 991

Query: 355  --CPEGLYGIKCD---KRC---PCHLENTHSCHPMSGE--CACKPGWSGLYCN---ETC- 400
              CP G  G++C+     C   PCH   T +CH ++    C C PG +G +C    + C 
Sbjct: 992  CACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCH 1051

Query: 401  -SPGFYGEACQQ--------ICSCQNGADCDSVTGK------------------------ 427
              P F+G  C+         IC C  G +  + + +                        
Sbjct: 1052 SQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFP 1111

Query: 428  --CTCAPGFKGIDCSTP-CPLGT-------YGINCSS---------RCGCKNDAV---CS 465
              C C  G+ G DC TP  P G        Y  +CS          RC C + +    C 
Sbjct: 1112 PRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQ 1171

Query: 466  -PVDGSCTCKAGWHGVDCSIRCPSGTW-GFGCNLTCQ-----CLNGGACNTLDGTCTCAP 518
             P    C  ++G    D     P G W G  C+L        C +   C  L     C P
Sbjct: 1172 KPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHP 1231

Query: 519  GWRGEKCELPCQDGTYGLNCAERCDCSHADGCHP--TTGHCR-----CLPGWSGVHCDSV 571
                E+C     DG Y       C  ++   CH     GHC         GW G  C   
Sbjct: 1232 QCDSEECLF---DG-YDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPE 1287

Query: 572  CAEGRWGPNCSL 583
              +  WGP+ +L
Sbjct: 1288 DGDPEWGPSLAL 1299



 Score =  141 bits (355), Expect = 4e-33
 Identities = 122/448 (27%), Positives = 162/448 (36%), Gaps = 126/448 (28%)

Query: 458 CKNDAVCSPVD---GSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTL---- 510
           C N   C  +    G+C C  G+ G  C    P       C     C NGG+C  L    
Sbjct: 35  CANGGTCLSLSLGQGTCQCAPGFLGETCQFPDP-------CQNAQLCQNGGSCQALLPAP 87

Query: 511 ------------DGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCR 558
                          CTC PG+ GE+C+   +D      C++R  C       P    C 
Sbjct: 88  LGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRP---QCS 144

Query: 559 CLPGWSGVHCD--SVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICS 616
           C+PGW+G  C     C+             C NG  C       +C            C 
Sbjct: 145 CMPGWTGEQCQLRDFCSANP----------CVNGGVCLATYPQIQCH-----------CP 183

Query: 617 PGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNC---AGIC 673
           PGF GH C +   +C    GPC   T   + L  F    C  +CP G+ G  C   AG C
Sbjct: 184 PGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQ---C--LCPVGQEGPRCELRAGPC 238

Query: 674 T---CTNNGTCNPIDRS------CQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFC 724
               C+N GTC  +         C C PG+IG DC           NC+ +  C NG  C
Sbjct: 239 PPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVN------PDNCV-SHQCQNGGTC 291

Query: 725 SAYDG----ECKCTPGWTGLYCTQRCPLGFYGKDCAL--ICQCQNGADCDHISG--QCTC 776
              DG     C C   WTG  C++         +C       C+NG  C + +G   C C
Sbjct: 292 Q--DGLDTYTCLCPETWTGWDCSEDV------DECETQGPPHCRNGGTCQNSAGSFHCVC 343

Query: 777 RTGFMGRHCEQK-------------------------CPSGTYGYGC--RQIC---DCLN 806
            +G+ G  CE+                          CP G  G  C    +C    C  
Sbjct: 344 VSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHG 403

Query: 807 NSTC--DHITGT--CYCSPGWKGARCDQ 830
           ++ C  + +TG+  C C PG+ G  C Q
Sbjct: 404 DAQCSTNPLTGSTLCLCQPGYSGPTCHQ 431


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  270 bits (689), Expect = 8e-72
 Identities = 255/882 (28%), Positives = 339/882 (38%), Gaps = 249/882 (28%)

Query: 93  QCCPGFYESGEMCVPHCADKCVHGRC-----------IAPNTCQCEPGWGGTNC------ 135
           +C  GF   GE C     D C   RC           +   TC+C  G+ G +C      
Sbjct: 52  KCPEGFL--GEYCQHR--DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSH 107

Query: 136 ----------------------SSACDGDHWGPHC--TSRC---QCKNGALCNPITG--A 166
                                    C     G  C  T  C    C NG+ C  +    +
Sbjct: 108 PCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFS 167

Query: 167 CHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTG--ECRCPPGYTGAFCEDL 224
           C C  GF G +CE      T  N+C     CQ+G TC ++ G  +C+CP G+TG +C+ L
Sbjct: 168 CKCLTGFTGQKCE------TDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSL 221

Query: 225 CPPGKHGPQCEQRCPCQNGGVCHHV---TGECSCPSGWMGTVCGQ---PCPEGRFGKNCS 278
             P      C    PC NGG C      T EC+C  G+ G+ C +    CP  R      
Sbjct: 222 YVP------CAP-SPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHR------ 268

Query: 279 QECQCHNGGTC--DAATGQCHCSPGYTGERCQ---DECPVGTYGVLCAETCQCVNGGKCY 333
               C NGG C     T  C C P +TG+ C    DEC      +L    CQ  NGG C 
Sbjct: 269 ----CQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDEC------LLQPNACQ--NGGTCA 316

Query: 334 HVSG--ACLCEAGFAGERCEAR------------------------LCPEGLYGIKC--D 365
           + +G   C+C  G++G+ C                           +CPEG  G+ C  D
Sbjct: 317 NRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLD 376

Query: 366 KRC---PCHLENTHSCHPMSGE--CACKPGWSGLYCNETCSPGFYGEACQQICS--CQNG 418
             C   PCH       +P++G+  C C  G+ G  C E        + C    S  C++ 
Sbjct: 377 DACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDV------DECAMANSNPCEHA 430

Query: 419 ADCDSVTG--KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDG--SCTCK 474
             C +  G   C C  G+ G  C          IN      C+NDA C    G  +C C 
Sbjct: 431 GKCVNTDGAFHCECLKGYAGPRCE-------MDINECHSDPCQNDATCLDKIGGFTCLCM 483

Query: 475 AGWHGVDCSI---RCPSGTWGFGCNLTCQCLNGGAC--NTLDGTCTCAPGWRGEKCELPC 529
            G+ GV C +    C S            C+N G C        C C PG+ G  C++  
Sbjct: 484 PGFKGVHCELEINECQSN----------PCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDI 533

Query: 530 QD--GTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYC 587
            D   T  LN A+  D       HP    C+C  G++GV C+          NC  P  C
Sbjct: 534 DDCSSTPCLNGAKCID-------HPNGYECQCATGFTGVLCEENI------DNCD-PDPC 579

Query: 588 KNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDC 647
            +G          +C  G    TC  IC+PG+ G  CS    +C   S PC +     D 
Sbjct: 580 HHG----------QCQDGIDSYTC--ICNPGYMGAICSDQIDECY--SSPCLNDGRCIDL 625

Query: 648 LPGFTGALCNEVCPSGRFGKNC-AGICTCTNN----GTC-NPIDR-SCQCYPGWIGSDCS 700
           + G+    CN  C  G  G NC      C +N    G C + I+R SC C PG+ G  C+
Sbjct: 626 VNGYQ---CN--CQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCN 680

Query: 701 ---QPCP--PAHWGPNCIH-----TCNCHNGAF---CSAYDGEC--------KCTPGWTG 739
                C   P   G  CI+      C C  G     C +   EC         CT G +G
Sbjct: 681 IDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSG 740

Query: 740 LYCTQRCPLGFYGKDC------ALICQCQNGADCDHISG--QCTCRTGFMGRHCE---QK 788
             C   C  G+ G +C       L   CQNG  CD++    +CTC+ GF G +C+    +
Sbjct: 741 YKCL--CDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDE 798

Query: 789 CPSGTYGYGCRQICDCLNNSTC-DHITG-TCYCSPGWKGARC 828
           C S            CLN  TC D I+G TC+C   + G  C
Sbjct: 799 CASN----------PCLNQGTCFDDISGYTCHCVLPYTGKNC 830



 Score =  265 bits (678), Expect = 1e-70
 Identities = 262/919 (28%), Positives = 334/919 (36%), Gaps = 256/919 (27%)

Query: 59   SCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMC---VPHC-ADKCV 114
            S T  LN  KC  H   Y              + QC  GF  +G +C   + +C  D C 
Sbjct: 537  SSTPCLNGAKCIDHPNGY--------------ECQCATGF--TGVLCEENIDNCDPDPCH 580

Query: 115  HGRC---IAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGA--CHC 169
            HG+C   I   TC C PG+ G  CS   D  +  P       C N   C  +     C+C
Sbjct: 581  HGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSP-------CLNDGRCIDLVNGYQCNC 633

Query: 170  AAGFRGWRCE--------DRCEQGTYGNDCHQ-RCQCQNGAT---CDHVTGECRCPPGYT 217
              G  G  CE        + C  G   +  ++  C C  G T   C+    EC   P   
Sbjct: 634  QPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRK 693

Query: 218  GAFCED-------LCPPGKHGPQCEQRC------PCQNGGVCHHVTG-ECSCPSGWMGTV 263
            GA C +       +CP G H P C  +       PC +G     ++G +C C +GW+G  
Sbjct: 694  GATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGIN 753

Query: 264  CGQPCPEGRFGKNCSQECQCHNGGTCDAATG--QCHCSPGYTGERCQ---DECPVGTYGV 318
            C          KN      C NGGTCD      +C C  G+ G  CQ   DEC       
Sbjct: 754  C-------EVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNP--- 803

Query: 319  LCAETCQCVNGGKCYH-VSG-ACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTH 376
                   C+N G C+  +SG  C C   + G+ C+  L P       C    PC  EN  
Sbjct: 804  -------CLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAP-------CSPN-PC--ENAA 846

Query: 377  SCHPM----SGECACKPGWSGLYCNET-------------------------CSPGFYGE 407
             C       S  C C PGW G  C                            C PGF G 
Sbjct: 847  VCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGM 906

Query: 408  ACQQICS------CQNGADC-DSV-TGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCK 459
             C++         CQNG  C D V T  C C PGF G  C T          C S   CK
Sbjct: 907  DCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMN------ECLSE-PCK 959

Query: 460  NDAVCSPVDGS--CTCKAGWHGVDC-------------------------SIRCPSGTWG 492
            N   CS    S  C C+AG+ GV C                         S  CP G  G
Sbjct: 960  NGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTG 1019

Query: 493  FGCNLTCQ------CLNGGACNTLDGT--CTCAPGWRGEKCELPCQDGTYGLNCAERCDC 544
              C           CLN G C    GT  C+C  G+ G+ C+         +N   R  C
Sbjct: 1020 SFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTL-------VNLCSRSPC 1072

Query: 545  SHADGC--HPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGAS--------CS 594
             +   C        C C  GW+G +CD         PN S    C   AS          
Sbjct: 1073 KNKGTCVQKKAESQCLCPSGWAGAYCDV--------PNVS----CDIAASRRGVLVEHLC 1120

Query: 595  PDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHH-------ITGL-CD 646
               G+C  A    G T    C  G+ G  C +   +C  +S PC H       I G  C+
Sbjct: 1121 QHSGVCINA----GNTHYCQCPLGYTGSYCEEQLDEC--ASNPCQHGATCSDFIGGYRCE 1174

Query: 647  CLPGFTGALCN---EVCPSGRFGKNCAGICTCTNNGTCNPIDR--SCQCYPGWIGSDCSQ 701
            C+PG+ G  C    + C +            C N GTC  +     C C PG  G  C +
Sbjct: 1175 CVPGYQGVNCEYEVDECQNQ----------PCQNGGTCIDLVNHFKCSCPPGTRGLLCEE 1224

Query: 702  PCPPAHWGPNCIHTCNCHNGAFCSAYDG--ECKCTPGWTGLYCTQRCPLGFYGKDCALIC 759
                   GP+C+      NG  C    G   C+C PG+ G    +RC  G   +  +  C
Sbjct: 1225 NIDDCARGPHCL------NGGQCMDRIGGYSCRCLPGFAG----ERCE-GDINECLSNPC 1273

Query: 760  QCQNGADCDHISGQ--CTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGT- 816
              +   DC  ++    C CR+ F GRHCE      T+   C Q+  CLN  TC   +   
Sbjct: 1274 SSEGSLDCIQLTNDYLCVCRSAFTGRHCE------TFVDVCPQM-PCLNGGTCAVASNMP 1326

Query: 817  ----CYCSPGWKGARCDQA 831
                C C PG+ GARC  +
Sbjct: 1327 DGFICRCPPGFSGARCQSS 1345



 Score =  262 bits (669), Expect = 2e-69
 Identities = 257/910 (28%), Positives = 338/910 (37%), Gaps = 264/910 (29%)

Query: 111 DKCVH-GRCIAPNT----CQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITG 165
           + CV+ G C+  +     C+C  G+ G  C       H  P   +RCQ     +   + G
Sbjct: 33  EPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQ------HRDPCEKNRCQNGGTCVAQAMLG 86

Query: 166 --ACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHV---TGECRCPPGYTGAF 220
              C CA+GF G  C     Q +  + C     C NG TC  +   T EC C  G+TG  
Sbjct: 87  KATCRCASGFTGEDC-----QYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKE 141

Query: 221 CE--DLCPPGKHGPQCEQRCPCQNGGVCHHVTGE--CSCPSGWMGTVCGQPCPEGRFGKN 276
           C+  D C             PC NG  C  V  +  C C +G+ G  C     E      
Sbjct: 142 CQWTDACLSH----------PCANGSTCTTVANQFSCKCLTGFTGQKCETDVNE------ 185

Query: 277 CSQECQCHNGGTCDAATG--QCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYH 334
           C     C +GGTC    G  QC C  G+TG+ C       +  V CA +  CVNGG C  
Sbjct: 186 CDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCD------SLYVPCAPS-PCVNGGTCRQ 238

Query: 335 VSG---ACLCEAGFAGERCEARL--CPEGLYGIKCDKRCPC-HLENTHSCHPMSGECACK 388
                  C C  GF G  CE  +  CP      +C     C    NT++C        C 
Sbjct: 239 TGDFTFECNCLPGFEGSTCERNIDDCPNH----RCQNGGVCVDGVNTYNCR-------CP 287

Query: 389 PGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGK--CTCAPGFKGIDCS------ 440
           P W+G +C E        E   Q  +CQNG  C +  G   C C  G+ G DCS      
Sbjct: 288 PQWTGQFCTEDVD-----ECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDC 342

Query: 441 -----TP--------------CPLGTYGINC--SSRC---GCKNDAVC--SPVDGS--CT 472
                TP              CP G  G+ C     C    C   A+C  +P++G   CT
Sbjct: 343 AFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICT 402

Query: 473 CKAGWHGVDCSIRCPSGTWGFGCNLTCQ--CLNGGACNTLDGT--CTCAPGWRGEKCELP 528
           C  G+ G DC+           C +     C + G C   DG   C C  G+ G +CE+ 
Sbjct: 403 CPQGYKGADCTEDVDE------CAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMD 456

Query: 529 CQDGTYGLNCAERCDCSHADGCHPTTGH--CRCLPGWSGVHCD----------------- 569
                  +N      C +   C    G   C C+PG+ GVHC+                 
Sbjct: 457 -------INECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQC 509

Query: 570 --------SVCAEGRWGPNCSLPCY------CKNGASC--SPDDGICECAPGFRGTTCQR 613
                    +C  G  GP C +         C NGA C   P+   C+CA GF G  C+ 
Sbjct: 510 VDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEE 569

Query: 614 ------------------------ICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLP 649
                                   IC+PG+ G  CS    +C   S PC +     D + 
Sbjct: 570 NIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECY--SSPCLNDGRCIDLVN 627

Query: 650 GFTGALCNEVCPSGRFGKNCA-GICTCTNN----GTC-NPIDR-SCQCYPGWIGSDCS-- 700
           G+    CN  C  G  G NC      C +N    G C + I+R SC C PG+ G  C+  
Sbjct: 628 GYQ---CN--CQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNID 682

Query: 701 -QPCP--PAHWGPNCIH-----TCNCHNGAF---CSAYDGEC--------KCTPGWTGLY 741
              C   P   G  CI+      C C  G     C +   EC         CT G +G  
Sbjct: 683 IDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYK 742

Query: 742 CTQRCPLGFYGKDC------ALICQCQNGADCDHISG--QCTCRTGFMGRHCE---QKCP 790
           C   C  G+ G +C       L   CQNG  CD++    +CTC+ GF G +C+    +C 
Sbjct: 743 CL--CDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECA 800

Query: 791 S------GTY-----GYGCRQICD-----------------CLNNSTCDHITG----TCY 818
           S      GT      GY C  +                   C N + C         TC 
Sbjct: 801 SNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCL 860

Query: 819 CSPGWKGARC 828
           C+PGW+G RC
Sbjct: 861 CAPGWQGQRC 870



 Score =  258 bits (660), Expect = 2e-68
 Identities = 283/1027 (27%), Positives = 355/1027 (34%), Gaps = 331/1027 (32%)

Query: 58   TSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGR 117
            ++CT + N F C                       +C  GF  +G+ C     +  + G 
Sbjct: 157  STCTTVANQFSC-----------------------KCLTGF--TGQKCETDVNECDIPGH 191

Query: 118  CIAPNTC---------QCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNP---ITG 165
            C    TC         QC  G+ G  C S      + P   S   C NG  C      T 
Sbjct: 192  CQHGGTCLNLPGSYQCQCPQGFTGQYCDSL-----YVPCAPS--PCVNGGTCRQTGDFTF 244

Query: 166  ACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATC-DHV-TGECRCPPGYTGAFC-E 222
             C+C  GF G  CE   +      DC    +CQNG  C D V T  CRCPP +TG FC E
Sbjct: 245  ECNCLPGFEGSTCERNID------DCPNH-RCQNGGVCVDGVNTYNCRCPPQWTGQFCTE 297

Query: 223  DLCPPGKHGPQCE-QRCPCQNGGVCHHVTGE--CSCPSGWMGTVCGQP------------ 267
            D+        +C  Q   CQNGG C +  G   C C +GW G  C +             
Sbjct: 298  DV-------DECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPG 350

Query: 268  -------------CPEGRFGKNCSQE--C---QCHNGGTCDA--ATGQ--CHCSPGYTGE 305
                         CPEG+ G  C  +  C    CH G  CD     GQ  C C  GY G 
Sbjct: 351  STCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGA 410

Query: 306  RCQ---DECPVGT-----YGVLCAET-----CQCVNG----------GKCYH-------- 334
             C    DEC +       +   C  T     C+C+ G           +C+         
Sbjct: 411  DCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDAT 470

Query: 335  ----VSG-ACLCEAGFAGERCEAR------------------------LCPEGLYGIKCD 365
                + G  CLC  GF G  CE                          LCP G  G  C 
Sbjct: 471  CLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQ 530

Query: 366  ------KRCPCHLENTHSC--HPMSGECACKPGWSGLYCNET------------------ 399
                     PC   N   C  HP   EC C  G++G+ C E                   
Sbjct: 531  IDIDDCSSTPCL--NGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGI 588

Query: 400  ------CSPGFYGEACQ-QICSC------QNGADCDSVTG-KCTCAPGFKGIDC------ 439
                  C+PG+ G  C  QI  C       +G   D V G +C C PG  G++C      
Sbjct: 589  DSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDD 648

Query: 440  --STPCPLGTY--GIN-----CS-----SRCGCKNDAVCS-PVDGSCTCKAGWHGVDCSI 484
              S PC  G    GIN     CS      RC    D   S P     TC  G +G  C  
Sbjct: 649  CASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCI- 707

Query: 485  RCPSGTWGFGCN------LTCQCLNGGACNTLDG-TCTCAPGWRGEKCEL--------PC 529
             CP G     C       L+  C++G     L G  C C  GW G  CE+        PC
Sbjct: 708  -CPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPC 766

Query: 530  QDGTYGLNCAE--RCDCS----------HADGC--HPTTGHCRCLPGWSGVHCDSVCAEG 575
            Q+G    N     RC C           + D C  +P      C    SG  C   C   
Sbjct: 767  QNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCH--CVLP 824

Query: 576  RWGPNCSLPCYCKNGASCSPDD----GICECAPGFRGTTCQRICSPGFYGHRCSQTCPQC 631
              G NC         A CSP+      +C+ +P F   TC  +C+PG+ G RC+    +C
Sbjct: 825  YTGKNCQTVL-----APCSPNPCENAAVCKESPNFESYTC--LCAPGWQGQRCTIDIDEC 877

Query: 632  VH----SSGPCHHITG--LCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTC--NP 683
            +     + G CH+  G  +C+C PGF+G  C E         +C     C N G+C    
Sbjct: 878  ISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDID------DCLAN-PCQNGGSCMDGV 930

Query: 684  IDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGE--CKCTPGWTGLY 741
               SC C PG+ G  C          P       C NG  CS Y     CKC  G+ G++
Sbjct: 931  NTFSCLCLPGFTGDKCQTDMNECLSEP-------CKNGGTCSDYVNSYTCKCQAGFDGVH 983

Query: 742  CTQRCPLGFYGKDCALICQCQNGADC-DHISG-QCTCRTGFMGRHCEQK----------- 788
            C           +C     C NG  C D I+   C C  GF G  C  +           
Sbjct: 984  CENNI------NECTE-SSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLN 1036

Query: 789  --------------CPSGTYGYGCRQICD------CLNNSTC--DHITGTCYCSPGWKGA 826
                          CP G  G  C+ + +      C N  TC        C C  GW GA
Sbjct: 1037 EGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGA 1096

Query: 827  RCDQAGV 833
             CD   V
Sbjct: 1097 YCDVPNV 1103



 Score =  253 bits (645), Expect = 9e-67
 Identities = 242/888 (27%), Positives = 317/888 (35%), Gaps = 260/888 (29%)

Query: 96   PGFYESGEMCVPHCADKCVHGRC---IAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRC 152
            P  Y     C+   ++ C+HG C   ++   C C+ GW G NC    +       C S  
Sbjct: 715  PSCYSQVNECL---SNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKN------ECLSN- 764

Query: 153  QCKNGALCNPITGA--CHCAAGFRGWRCE---DRC------EQGTYGNDCH-QRCQC--- 197
             C+NG  C+ +     C C  GF+G+ C+   D C       QGT  +D     C C   
Sbjct: 765  PCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLP 824

Query: 198  QNGATCDHVTGECRCPPGYTGAFCED---------LCPPGKHGPQCE---QRC---PCQN 242
              G  C  V   C   P    A C++         LC PG  G +C      C   PC N
Sbjct: 825  YTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMN 884

Query: 243  GGVCHHVTGE--CSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTC--DAATGQCHC 298
             G+CH+  G   C CP G+ G  C +   +      C     C NGG+C     T  C C
Sbjct: 885  HGLCHNTQGSYMCECPPGFSGMDCEEDIDD------CLAN-PCQNGGSCMDGVNTFSCLC 937

Query: 299  SPGYTGERCQ---DECPVGTYGVLCAETCQCVNGGKC--YHVSGACLCEAGFAGERCEAR 353
             PG+TG++CQ   +EC         +E C+  NGG C  Y  S  C C+AGF G  CE  
Sbjct: 938  LPGFTGDKCQTDMNEC--------LSEPCK--NGGTCSDYVNSYTCKCQAGFDGVHCENN 987

Query: 354  L-------------CPEGLYGIKCDKRCPC--------HLENTHSCHPMSGECACKPGWS 392
            +             C +G+    C   CP         H  N  S HP   E  C  G  
Sbjct: 988  INECTESSCFNGGTCVDGINSFSC--LCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLG 1045

Query: 393  GLYCNETCSPGFYGEACQ---QICS---CQNGADC--DSVTGKCTCAPGFKGIDCSTP-- 442
               C+  C  G+ G+ CQ    +CS   C+N   C       +C C  G+ G  C  P  
Sbjct: 1046 TYRCS--CPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNV 1103

Query: 443  ---------------------------------CPLGTYGINCSSRCG------CKNDAV 463
                                             CPLG  G  C  +        C++ A 
Sbjct: 1104 SCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGAT 1163

Query: 464  CSPVDGS--CTCKAGWHGVDCSIRCPSGTWGFGCNLTCQ---CLNGGACNTLDG--TCTC 516
            CS   G   C C  G+ GV+C                CQ   C NGG C  L     C+C
Sbjct: 1164 CSDFIGGYRCECVPGYQGVNCEYEVDE----------CQNQPCQNGGTCIDLVNHFKCSC 1213

Query: 517  APGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDS------ 570
             PG RG  CE    D   G +C     C    G +     CRCLPG++G  C+       
Sbjct: 1214 PPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYS----CRCLPGFAGERCEGDINECL 1269

Query: 571  ---------------------VCAEGRWGPNCS--------LPCYCKNGASCS-----PD 596
                                 VC     G +C         +PC   NG +C+     PD
Sbjct: 1270 SNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCL--NGGTCAVASNMPD 1327

Query: 597  DGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALC 656
              IC C PGF G  CQ  C     G    +   QCVH++                +G  C
Sbjct: 1328 GFICRCPPGFSGARCQSSC-----GQVKCRKGEQCVHTA----------------SGPRC 1366

Query: 657  NEVCPSGRFGKNCAGICTCTNNGTCNPIDR----SCQCYPGWIGSDC------------- 699
               CPS R  ++      C + G+C+P  +    SCQC P + GS C             
Sbjct: 1367 --FCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPAT 1424

Query: 700  --SQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFY-GKDCA 756
              SQ C        C   CN H    C    G+C  T       C+   P   Y    C 
Sbjct: 1425 CLSQYCADKARDGVCDEACNSH---ACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCD 1481

Query: 757  LIC---QCQ-NGADCDHISGQCT----CRTGFMGRHCEQKCPSGTYGY 796
             +C   +C  +  +C   S  C     C   F   HC+Q C S   G+
Sbjct: 1482 ELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGW 1529



 Score =  137 bits (344), Expect = 8e-32
 Identities = 130/489 (26%), Positives = 178/489 (36%), Gaps = 142/489 (29%)

Query: 116  GRCI---APNTCQCEPGWGGTNC---SSACD--GDHWGPHCTSRCQCKNGALCNPITGAC 167
            G C+   A + C C  GW G  C   + +CD      G      CQ     +    T  C
Sbjct: 1076 GTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYC 1135

Query: 168  HCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTG--ECRCPPGYTGAFCEDLC 225
             C  G+ G  CE++ ++      C     CQ+GATC    G   C C PGY G  CE   
Sbjct: 1136 QCPLGYTGSYCEEQLDE------CASN-PCQHGATCSDFIGGYRCECVPGYQGVNCE--- 1185

Query: 226  PPGKHGPQCEQRCPCQNGGVCHHVTG--ECSCPSGWMGTVCGQPCPEGRFGKNCSQECQC 283
                   +C+ + PCQNGG C  +    +CSCP G  G +C +   +      C++   C
Sbjct: 1186 ---YEVDECQNQ-PCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDD------CARGPHC 1235

Query: 284  HNGGTCDAATG--QCHCSPGYTGERCQ---DEC---PVGTYGVL-CAET----------- 323
             NGG C    G   C C PG+ GERC+   +EC   P  + G L C +            
Sbjct: 1236 LNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSA 1295

Query: 324  -----CQ----------CVNGGKCYHVSGA-----CLCEAGFAGERCEARL----CPEGL 359
                 C+          C+NGG C   S       C C  GF+G RC++      C +G 
Sbjct: 1296 FTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGE 1355

Query: 360  YGIK--------------CDKRC---PCHLENTHSCHPMSG----ECACKPGWSGLYC-- 396
              +               C+  C   PC  ++  SCHP        C C P +SG  C  
Sbjct: 1356 QCVHTASGPRCFCPSPRDCESGCASSPC--QHGGSCHPQRQPPYYSCQCAPPFSGSRCEL 1413

Query: 397  -------------NETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPC 443
                         ++ C+       C + C   N   C    G C+        +CS+P 
Sbjct: 1414 YTAPPSTPPATCLSQYCADKARDGVCDEAC---NSHACQWDGGDCSLTMENPWANCSSPL 1470

Query: 444  PLGTYGIN-CSSRCG-----------------CKNDAVCSP------VDGSCTCK-AGWH 478
            P   Y  N C   C                  CK D  C+        D  C  +  GW 
Sbjct: 1471 PCWDYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWD 1530

Query: 479  GVDCSIRCP 487
            G+DC+   P
Sbjct: 1531 GLDCAADQP 1539



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 75/271 (27%), Positives = 110/271 (40%), Gaps = 51/271 (18%)

Query: 581 CSLPCY---CKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCP----QCVH 633
           C+ P +   C++G     ++G+C     +   T    C  GF G  C    P    +C  
Sbjct: 19  CAAPAHALQCRDGYEPCVNEGMCVT---YHNGTGYCKCPEGFLGEYCQHRDPCEKNRC-Q 74

Query: 634 SSGPCHHITGL----CDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRS-- 687
           + G C     L    C C  GFTG  C        F         C N GTC+ + R   
Sbjct: 75  NGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSR-----PCLNGGTCHMLSRDTY 129

Query: 688 -CQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGE--CKCTPGWTGLYCTQ 744
            C C  G+ G +C        W   C+ +  C NG+ C+    +  CKC  G+TG    Q
Sbjct: 130 ECTCQVGFTGKECQ-------WTDACL-SHPCANGSTCTTVANQFSCKCLTGFTG----Q 177

Query: 745 RCPLGFYGKDCALICQCQNGADCDHISG--QCTCRTGFMGRHCEQKCPSGTYGYGCRQIC 802
           +C       +C +   CQ+G  C ++ G  QC C  GF G++C+         Y      
Sbjct: 178 KCETDV--NECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSL-------YVPCAPS 228

Query: 803 DCLNNSTCDH---ITGTCYCSPGWKGARCDQ 830
            C+N  TC      T  C C PG++G+ C++
Sbjct: 229 PCVNGGTCRQTGDFTFECNCLPGFEGSTCER 259


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  234 bits (596), Expect = 5e-61
 Identities = 248/881 (28%), Positives = 321/881 (36%), Gaps = 224/881 (25%)

Query: 15  LLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRV 74
           LL   +  A  +N ED     H+  +   ++       D+ YY++  +     K  R R 
Sbjct: 161 LLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCN-----KFCRPRN 215

Query: 75  SYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKC--VHGRCIAPNTCQCEPGWGG 132
            +      G  T  +  ++ C   +   E     C   C  +HG C  P  C+C  GW G
Sbjct: 216 DF-----FGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQG 270

Query: 133 TNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCH 192
             C            C     C +G+   P    C+C   + G  C+         N C 
Sbjct: 271 RFCD----------ECVPYPGCVHGSCVEP--WQCNCETNWGGLLCDKDL------NYCG 312

Query: 193 QRCQCQNGATCDHVTGE---CRCPPGYTGAFCEDLCPPGKHGPQCEQRC---PCQNGGVC 246
               C NG TC +   +   C CP GY+G  CE          + E  C   PC NGG C
Sbjct: 313 SHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE----------KAEHACTSNPCANGGSC 362

Query: 247 HHVTG--ECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTC-DAATG-QCHCSPGY 302
           H V    EC CPSGW G  C     E      C+    C  GGTC D   G +C C   +
Sbjct: 363 HEVPSGFECHCPSGWSGPTCALDIDE------CASN-PCAAGGTCVDQVDGFECICPEQW 415

Query: 303 TGERCQDECPVGTYGVLCAETCQ---CVNGGKCYHVSGA--CLCEAGFAGERCEARL--- 354
            G  CQ          L A  C+   C+N   C ++ G   C C  G+ G  C   +   
Sbjct: 416 VGATCQ----------LDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC 465

Query: 355 ---------CPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNET------ 399
                    C + + G +C   CP      H C     ECA  P  SG  C +       
Sbjct: 466 RGQCQHGGTCKDLVNGYQC--VCPRGFGGRH-CELERDECASSPCHSGGLCEDLADGFHC 522

Query: 400 -CSPGFYGEACQ---QICS---CQNGADCDSVTGK--CTCAPGFKGIDCST---PCPLGT 447
            C  GF G  C+    +C    C+NGA C ++ G   C C   F G +CS    PCP G 
Sbjct: 523 HCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA 582

Query: 448 YGINCSSRCGCKNDA-----------VCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCN 496
               C    GC +DA           VC P  G C  + G    + S  C SG  G  C+
Sbjct: 583 ----CRVIDGCGSDAGPGMPGTAASGVCGP-HGRCVSQPGG---NFSCICDSGFTGTYCH 634

Query: 497 ------LTCQCLNGGAC-NTLDG-TCTCAPGWRGEKCE------LP-------------- 528
                 L   C NGG C + +D   C C  GW GE C+      LP              
Sbjct: 635 ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVN 694

Query: 529 -----CQDGTYGLNCAER---CD---CSHADGCHPT--TGHCRCLPGWSGVHCDSVCAEG 575
                C DG  G  C  R   CD   CS+   C+ +  T  C C PGW G    S CA  
Sbjct: 695 DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKG----STCAVA 750

Query: 576 RWGPNCSLPCYCKNGASC--SPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVH 633
           +   +C LP  C NG +C  S     C C  G+ G TC          H  +   P   +
Sbjct: 751 K-NSSC-LPNPCVNGGTCVGSGASFSCICRDGWEGRTCT---------HNTNDCNPLPCY 799

Query: 634 SSGPCHHITGL----CDCLPGFTGALCN---EVCPSGRFGKNCAGICTCTN--NGTCNPI 684
           + G C  + G+    C+C PGF G  C    + C S      CA   TC +  NG     
Sbjct: 800 NGGIC--VDGVNWFRCECAPGFAGPDCRINIDECQS----SPCAYGATCVDEING----- 848

Query: 685 DRSCQCYPGWIGSDCSQPC----------PPAHWGPNCIHTCNCHNGAFCSAYDGECKCT 734
              C C PG  G  C +             P   G + +  CN      C   DG   C+
Sbjct: 849 -YRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNS-----CRCLDGRRDCS 902

Query: 735 PGWTGLYCTQRCPLGFYGKDCALICQCQNGADC-DHISGQC 774
             W G       P    G+  AL  QC  G  C +   GQC
Sbjct: 903 KVWCGWK-----PCLLAGQPEALSAQCPLGQRCLEKAPGQC 938



 Score =  211 bits (537), Expect = 3e-54
 Identities = 214/772 (27%), Positives = 284/772 (36%), Gaps = 185/772 (23%)

Query: 139 CDGDHWGPHCTSRCQCKN---GALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRC 195
           CD +++   C   C+ +N   G       G   C  G+ G  C++          C Q C
Sbjct: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV--------CKQGC 249

Query: 196 QCQNGATCDHVTGECRCPPGYTGAFCEDLCP-PG-KHGP--------------------- 232
              +G     V GECRC  G+ G FC++  P PG  HG                      
Sbjct: 250 NLLHGGCT--VPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKD 307

Query: 233 --QCEQRCPCQNGGVCHHVTGE---CSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGG 287
              C    PC NGG C +   +   C+CP G+ G  C +        ++      C NGG
Sbjct: 308 LNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK-------AEHACTSNPCANGG 360

Query: 288 TCDAATG--QCHCSPGYTGERCQ---DECPVGTYGVLCAETCQCVNGGKCY-HVSG-ACL 340
           +C       +CHC  G++G  C    DEC              C  GG C   V G  C+
Sbjct: 361 SCHEVPSGFECHCPSGWSGPTCALDIDECASNP----------CAAGGTCVDQVDGFECI 410

Query: 341 CEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGE--CACKPGWSGLYCNE 398
           C   + G  C+       L   +C+ + PC   N  SC  + G   C C PGW G+ C+ 
Sbjct: 411 CPEQWVGATCQ-------LDANECEGK-PCL--NAFSCKNLIGGYYCDCIPGWKGINCHI 460

Query: 399 TCSPGFYGEACQQICSCQNGADC-DSVTG-KCTCAPGFKGIDCSTPCPLGTYGINCSSRC 456
             +       C+    CQ+G  C D V G +C C  GF G  C                 
Sbjct: 461 NVND------CRG--QCQHGGTCKDLVNGYQCVCPRGFGGRHCELE-------------- 498

Query: 457 GCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLT---CQ---CLNGGACNTL 510
             +++   SP      C+    G  C   CP G  G  C +    C+   C NG  C  L
Sbjct: 499 --RDECASSPCHSGGLCEDLADGFHC--HCPQGFSGPLCEVDVDLCEPSPCRNGARCYNL 554

Query: 511 DGT--CTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHC 568
           +G   C C   + G+ C +P +    G        C   DGC    G     PG  G   
Sbjct: 555 EGDYYCACPDDFGGKNCSVPREPCPGGA-------CRVIDGCGSDAG-----PGMPGTAA 602

Query: 569 DSVCA-EGRW--GPNCSLPCYCKNGAS---CSPDDGICECAPGFRGTTC-------QRIC 615
             VC   GR    P  +  C C +G +   C  +   C   P   G TC       +  C
Sbjct: 603 SGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFC 662

Query: 616 SPGFYGHRCSQTCPQCV----HSSGPCHHITG--LCDCLPGFTGALCNEVCPSGRFGKNC 669
             G+ G  C      C+    HS G C+ +     C C  G+ G  C+    S  F   C
Sbjct: 663 PSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCH----SREF--QC 716

Query: 670 AGICTCTNNGTCNPIDRS--CQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFC--S 725
               TC+N GTC     +  C C PGW GS C+          +C+    C NG  C  S
Sbjct: 717 DAY-TCSNGGTCYDSGDTFRCACPPGWKGSTCA-----VAKNSSCLPN-PCVNGGTCVGS 769

Query: 726 AYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADC-DHISG-QCTCRTGFMGR 783
                C C  GW G  CT          DC  +  C NG  C D ++  +C C  GF G 
Sbjct: 770 GASFSCICRDGWEGRTCTHNT------NDCNPL-PCYNGGICVDGVNWFRCECAPGFAGP 822

Query: 784 HCE---QKCPSGTYGYGCRQICDCLNNSTC-DHITG-TCYCSPGWKGARCDQ 830
            C     +C S    YG          +TC D I G  C C PG  G RC +
Sbjct: 823 DCRINIDECQSSPCAYG----------ATCVDEINGYRCSCPPGRAGPRCQE 864



 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 48/188 (25%), Positives = 71/188 (37%), Gaps = 41/188 (21%)

Query: 647 CLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPA 706
           C   +  A CN+ C   R   +  G  TC   G       +  C  GW+G +C +     
Sbjct: 198 CDENYYSATCNKFC---RPRNDFFGHYTCDQYG-------NKACMDGWMGKECKEAV--- 244

Query: 707 HWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGAD 766
                C   CN  +G  C+   GEC+C+ GW G +C +          C     C +G+ 
Sbjct: 245 -----CKQGCNLLHGG-CTV-PGECRCSYGWQGRFCDE----------CVPYPGCVHGSC 287

Query: 767 CDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGT---CYCSPGW 823
            +    QC C T + G  C++          C     C N  TC +       C C  G+
Sbjct: 288 VE--PWQCNCETNWGGLLCDKDLNY------CGSHHPCTNGGTCINAEPDQYRCTCPDGY 339

Query: 824 KGARCDQA 831
            G  C++A
Sbjct: 340 SGRNCEKA 347



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 27/90 (30%), Positives = 40/90 (44%), Gaps = 15/90 (16%)

Query: 745 RCPLGFYGKDCALICQCQNGA----DCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQ 800
           RC   +Y   C   C+ +N       CD   G   C  G+MG+ C++          C+Q
Sbjct: 197 RCDENYYSATCNKFCRPRNDFFGHYTCDQY-GNKACMDGWMGKECKEAV--------CKQ 247

Query: 801 ICDCLNNSTCDHITGTCYCSPGWKGARCDQ 830
            C+ L+      + G C CS GW+G  CD+
Sbjct: 248 GCNLLHGGCT--VPGECRCSYGWQGRFCDE 275


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  229 bits (585), Expect = 9e-60
 Identities = 221/738 (29%), Positives = 270/738 (36%), Gaps = 181/738 (24%)

Query: 105 CVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALC---N 161
           CVP+    CVHG C+ P  C CE  WGG  C    +      +C S   C NG  C    
Sbjct: 276 CVPYPG--CVHGSCVEPWQCNCETNWGGLLCDKDLN------YCGSHHPCTNGGTCINAE 327

Query: 162 PITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTG--ECRCPPGYTGA 219
           P    C C  G+ G  CE + E     N       C NG +C  V    EC CP G++G 
Sbjct: 328 PDQYRCTCPDGYSGRNCE-KAEHACTSN------PCANGGSCHEVPSGFECHCPSGWSGP 380

Query: 220 FCE---DLCPPGKHGPQCEQRCPCQNGGVC-HHVTG-ECSCPSGWMGTVC--------GQ 266
            C    D C             PC  GG C   V G EC CP  W+G  C        GQ
Sbjct: 381 TCALDIDECASN----------PCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ 430

Query: 267 ----------------PCPEGRFGKNCS---QEC---QCHNGGTC-DAATG-QCHCSPGY 302
                            CP G  G++C     EC    CH+GG C D A G  CHC  G+
Sbjct: 431 CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF 490

Query: 303 TGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSG--ACLCEAGFAGERCEA--RLCPEG 358
           +G  C+ +        LC E   C NG +CY++ G   C C   F G+ C      CP G
Sbjct: 491 SGPLCEVDVD------LC-EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGG 543

Query: 359 LYGI--KCDKRCPCHLENTHS---CHPMSGECACKPGWSGLYCNETCSPGFYGEACQQIC 413
              +   C       +  T +   C P  G C  +PG     C   C  GF G  C +  
Sbjct: 544 ACRVIDGCGSDAGPGMPGTAASGVCGP-HGRCVSQPG-GNFSC--ICDSGFTGTYCHENI 599

Query: 414 S------CQNGADC-DSVTG-KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCS 465
                  C+NG  C D V   +C C  G++G  C T  P       C SR  C  D V  
Sbjct: 600 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTN-PNDCLPDPCHSRGRC-YDLV-- 655

Query: 466 PVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGT--CTCAPGWRGE 523
             D  C C  GW G  C  R       F C+    C NGG C     T  C C PGW+G 
Sbjct: 656 -NDFYCACDDGWKGKTCHSR------EFQCD-AYTCSNGGTCYDSGDTFRCACPPGWKGS 707

Query: 524 KCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCS- 582
            C +          C     C  +      +  C C  GW G  C     +      C+ 
Sbjct: 708 TCAVAKNSSCLPNPCVNGGTCVGSG----ASFSCICRDGWEGRTCTHNTND------CNP 757

Query: 583 LPCYCKNGASCSPDDGI----CECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPC 638
           LPCY  NG  C   DG+    CECAPGF G  C+             Q+ P C + +   
Sbjct: 758 LPCY--NGGICV--DGVNWFRCECAPGFAGPDCRINIDE-------CQSSP-CAYGATCV 805

Query: 639 HHITGL-CDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGS 697
             I G  C C PG  G  C EV   GR         +C + GT                 
Sbjct: 806 DEINGYRCSCPPGRAGPRCQEVIGFGR---------SCWSRGT----------------- 839

Query: 698 DCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCAL 757
                  P   G + +  CN      C   DG   C+  W G       P    G+  AL
Sbjct: 840 -------PFPHGSSWVEDCNS-----CRCLDGRRDCSKVWCGWK-----PCLLAGQPEAL 882

Query: 758 ICQCQNGADC-DHISGQC 774
             QC  G  C +   GQC
Sbjct: 883 SAQCPLGQRCLEKAPGQC 900



 Score =  199 bits (506), Expect = 1e-50
 Identities = 204/723 (28%), Positives = 265/723 (36%), Gaps = 166/723 (22%)

Query: 181 RCEQGTYGNDCHQRCQCQNGA----TCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQ 236
           RC++  Y   C++ C+ +N      TCD   G   C  G+ G  C++          C+Q
Sbjct: 197 RCDENYYSATCNKFCRPRNDFFGHYTCDQY-GNKACMDGWMGKECKEAV--------CKQ 247

Query: 237 RCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQC 296
            C   +GG    V GEC C  GW          +GRF   C     C +G   +    QC
Sbjct: 248 GCNLLHGGCT--VPGECRCSYGW----------QGRFCDECVPYPGCVHGSCVEP--WQC 293

Query: 297 HCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSG---ACLCEAGFAGERCEAR 353
           +C   + G  C  +         C     C NGG C +       C C  G++G  CE  
Sbjct: 294 NCETNWGGLLCDKDLNY------CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE-- 345

Query: 354 LCPEGLYGIKCDKRC---PCHLENTHSCH--PMSGECACKPGWSGLYC--------NETC 400
                    K +  C   PC   N  SCH  P   EC C  GWSG  C        +  C
Sbjct: 346 ---------KAEHACTSNPC--ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPC 394

Query: 401 SPGFYGEACQQI----CSCQN---GADC----DSVTGKC----TCAPGFKGIDCSTPCPL 445
           + G  G    Q+    C C     GA C    +   G+C    TC     G  C   CP 
Sbjct: 395 AAG--GTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCV--CPR 450

Query: 446 GTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLT---CQ-- 500
           G  G +C      +++   SP      C+    G  C   CP G  G  C +    C+  
Sbjct: 451 GFGGRHCELE---RDECASSPCHSGGLCEDLADGFHC--HCPQGFSGPLCEVDVDLCEPS 505

Query: 501 -CLNGGACNTLDGT--CTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHC 557
            C NG  C  L+G   C C   + G+ C +P +    G        C   DGC    G  
Sbjct: 506 PCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA-------CRVIDGCGSDAG-- 556

Query: 558 RCLPGWSGVHCDSVCA-EGRW--GPNCSLPCYCKNGAS---CSPDDGICECAPGFRGTTC 611
              PG  G     VC   GR    P  +  C C +G +   C  +   C   P   G TC
Sbjct: 557 ---PGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTC 613

Query: 612 -------QRICSPGFYGHRCSQTCPQCV----HSSGPCHHITG--LCDCLPGFTGALCNE 658
                  +  C  G+ G  C      C+    HS G C+ +     C C  G+ G  C+ 
Sbjct: 614 IDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCH- 672

Query: 659 VCPSGRFGKNCAGICTCTNNGTCNPIDRS--CQCYPGWIGSDCSQPCPPAHWGPNCIHTC 716
              S  F   C    TC+N GTC     +  C C PGW GS C+          +C+   
Sbjct: 673 ---SREF--QCDAY-TCSNGGTCYDSGDTFRCACPPGWKGSTCA-----VAKNSSCLPN- 720

Query: 717 NCHNGAFC--SAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADC-DHISG- 772
            C NG  C  S     C C  GW G  CT          DC  +  C NG  C D ++  
Sbjct: 721 PCVNGGTCVGSGASFSCICRDGWEGRTCTHNT------NDCNPL-PCYNGGICVDGVNWF 773

Query: 773 QCTCRTGFMGRHCE---QKCPSGTYGYGCRQICDCLNNSTC-DHITG-TCYCSPGWKGAR 827
           +C C  GF G  C     +C S    YG          +TC D I G  C C PG  G R
Sbjct: 774 RCECAPGFAGPDCRINIDECQSSPCAYG----------ATCVDEINGYRCSCPPGRAGPR 823

Query: 828 CDQ 830
           C +
Sbjct: 824 CQE 826


>gi|153946395 tenascin C precursor [Homo sapiens]
          Length = 2201

 Score =  220 bits (561), Expect = 5e-57
 Identities = 178/583 (30%), Positives = 223/583 (38%), Gaps = 176/583 (30%)

Query: 124 CQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCE 183
           C CEPGW G NCS         P C   C  +       I G C C  GF G    + C 
Sbjct: 174 CVCEPGWKGPNCSE--------PECPGNCHLRGRC----IDGQCICDDGFTG----EDCS 217

Query: 184 QGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCE-DLCPPGKHGPQCEQRCPC-Q 241
           Q    +DC+ + +C NG         C C  GY GA C  ++CP            PC +
Sbjct: 218 QLACPSDCNDQGKCVNGV--------CICFEGYAGADCSREICP-----------VPCSE 258

Query: 242 NGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPG 301
             G C  V G C C  G+ G  C +P         C   C  +N G C     +C C  G
Sbjct: 259 EHGTC--VDGLCVCHDGFAGDDCNKPL--------CLNNC--YNRGRC--VENECVCDEG 304

Query: 302 YTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCP----- 356
           +TGE C +        ++C     C + G+C  ++G C CE GF GE C    CP     
Sbjct: 305 FTGEDCSE--------LICPN--DCFDRGRC--INGTCYCEEGFTGEDCGKPTCPHACHT 352

Query: 357 ------------EGLYGIKC-DKRCPCHLENTHSCHPMSGECACKPGWSGLYCNE----- 398
                       EG  G+ C +KRCP    N   C  + G C C  G++G  C E     
Sbjct: 353 QGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRC--VDGRCECDDGFTGADCGELKCPN 410

Query: 399 -------------TCSPGFYGEACQQICSCQNGADCDS----VTGKCTCAPGFKGIDCS- 440
                         C  G+ GE C Q+  C N  DC S    V GKC C  GFKG DCS 
Sbjct: 411 GCSGHGRCVNGQCVCDEGYTGEDCSQL-RCPN--DCHSRGRCVEGKCVCEQGFKGYDCSD 467

Query: 441 TPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIR-CPSGTWGFGCNLTC 499
             CP      +C     C        V+G C C  G+ G DC  R CP            
Sbjct: 468 MSCP-----NDCHQHGRC--------VNGMCVCDDGYTGEDCRDRQCPR----------- 503

Query: 500 QCLNGGACNTLDGTCTCAPGWRGEKC-ELPCQDGTYGLNCAERCDCSHADGCHPTTGHCR 558
            C N G C  +DG C C  G+ G  C EL C +  +G     RC            G C 
Sbjct: 504 DCSNRGLC--VDGQCVCEDGFTGPDCAELSCPNDCHGQG---RC----------VNGQCV 548

Query: 559 CLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPG 618
           C  G+ G  C            C  P  C     C   DG C C  GF G  C +     
Sbjct: 549 CHEGFMGKDCKE--------QRC--PSDCHGQGRCV--DGQCICHEGFTGLDCGQ----- 591

Query: 619 FYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCP 661
                   +CP   ++ G C  ++G C C  G++G  C+EV P
Sbjct: 592 -------HSCPSDCNNLGQC--VSGRCICNEGYSGEDCSEVSP 625



 Score =  219 bits (559), Expect = 9e-57
 Identities = 181/596 (30%), Positives = 233/596 (39%), Gaps = 182/596 (30%)

Query: 283 CHNGGTCDAATGQCHCSPGYTGERCQD-ECPVGTYGVLCAETCQCVNGGKCYHVSGACLC 341
           C   G        C C PG+ G  C + ECP             C   G+C  + G C+C
Sbjct: 161 CSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGN-----------CHLRGRC--IDGQCIC 207

Query: 342 EAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCS 401
           + GF GE C    CP       C+ +  C          ++G C C  G++G  C+    
Sbjct: 208 DDGFTGEDCSQLACPSD-----CNDQGKC----------VNGVCICFEGYAGADCSR--- 249

Query: 402 PGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKND 461
                E C   CS ++G   D   G C C  GF G DC+ P  L     NC +R  C   
Sbjct: 250 -----EICPVPCSEEHGTCVD---GLCVCHDGFAGDDCNKPLCLN----NCYNRGRC--- 294

Query: 462 AVCSPVDGSCTCKAGWHGVDCS-IRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGW 520
                V+  C C  G+ G DCS + CP+            C + G C  ++GTC C  G+
Sbjct: 295 -----VENECVCDEGFTGEDCSELICPN-----------DCFDRGRC--INGTCYCEEGF 336

Query: 521 RGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPN 580
            GE C  P               C HA  CH T G C             VC EG  G +
Sbjct: 337 TGEDCGKPT--------------CPHA--CH-TQGRCE--------EGQCVCDEGFAGVD 371

Query: 581 CS---LPCYCKNGASCSPDDGICECAPGFRGTTC------------------QRICSPGF 619
           CS    P  C N   C   DG CEC  GF G  C                  Q +C  G+
Sbjct: 372 CSEKRCPADCHNRGRCV--DGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGY 429

Query: 620 YGHRCSQT-CPQCVHSSGPCHHITGLCDCLPGFTGALCNEV-CPSGRFGKNCAGICTCTN 677
            G  CSQ  CP   HS G C  + G C C  GF G  C+++ CP+            C  
Sbjct: 430 TGEDCSQLRCPNDCHSRGRC--VEGKCVCEQGFKGYDCSDMSCPND-----------CHQ 476

Query: 678 NGTCNPIDRSCQCYPGWIGSDC-SQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPG 736
           +G C  ++  C C  G+ G DC  + CP            +C N   C   DG+C C  G
Sbjct: 477 HGRC--VNGMCVCDDGYTGEDCRDRQCPR-----------DCSNRGLC--VDGQCVCEDG 521

Query: 737 WTGLYCTQ-RCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHC-EQKCPSGTY 794
           +TG  C +  CP      DC    +C NG        QC C  GFMG+ C EQ+CPS  +
Sbjct: 522 FTGPDCAELSCP-----NDCHGQGRCVNG--------QCVCHEGFMGKDCKEQRCPSDCH 568

Query: 795 GYG-C---RQIC----------------DCLNNSTCDHITGTCYCSPGWKGARCDQ 830
           G G C   + IC                DC N   C  ++G C C+ G+ G  C +
Sbjct: 569 GQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQC--VSGRCICNEGYSGEDCSE 622



 Score =  204 bits (519), Expect = 4e-52
 Identities = 183/590 (31%), Positives = 227/590 (38%), Gaps = 178/590 (30%)

Query: 194 RCQCQNGATC--DHVTGECRCPPGYTGAF------CEDLCPPGKHGPQC-EQRCPCQNGG 244
           R QC  GA C     TG     P  +G        C  +C PG  GP C E  CP    G
Sbjct: 137 REQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECP----G 192

Query: 245 VCHHVTGECSCPSGWMGTVCGQP-CPEGRFGKNCSQ---ECQCHNGGTCDAATGQCHCSP 300
            CH + G C         + GQ  C +G  G++CSQ      C++ G C    G C C  
Sbjct: 193 NCH-LRGRC---------IDGQCICDDGFTGEDCSQLACPSDCNDQGKC--VNGVCICFE 240

Query: 301 GYTGERCQDE-CPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGL 359
           GY G  C  E CPV      C+E       G C  V G C+C  GFAG+ C   LC    
Sbjct: 241 GYAGADCSREICPVP-----CSE-----EHGTC--VDGLCVCHDGFAGDDCNKPLCLNNC 288

Query: 360 YGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNET------------------CS 401
           Y             N   C  +  EC C  G++G  C+E                   C 
Sbjct: 289 Y-------------NRGRC--VENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCE 333

Query: 402 PGFYGEAC-QQIC--SCQNGADCDSVTGKCTCAPGFKGIDCSTP-CPLGTYGINCSSRCG 457
            GF GE C +  C  +C     C+   G+C C  GF G+DCS   CP      +C +R  
Sbjct: 334 EGFTGEDCGKPTCPHACHTQGRCEE--GQCVCDEGFAGVDCSEKRCPA-----DCHNRGR 386

Query: 458 CKNDAVCSPVDGSCTCKAGWHGVDCS-IRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTC 516
           C        VDG C C  G+ G DC  ++CP+G  G G     +C+NG         C C
Sbjct: 387 C--------VDGRCECDDGFTGADCGELKCPNGCSGHG-----RCVNG--------QCVC 425

Query: 517 APGWRGEKC------------------ELPCQDGTYGLNCAERCDCSHADGCHPTTGHCR 558
             G+ GE C                  +  C+ G  G +C+   D S  + CH    H R
Sbjct: 426 DEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCS---DMSCPNDCHQ---HGR 479

Query: 559 CLPGWSGVHCDSVCAEGRWGPNC---SLPCYCKNGASCSPDDGICECAPGFRGTTC---- 611
           C+ G        VC +G  G +C     P  C N   C   DG C C  GF G  C    
Sbjct: 480 CVNGMC------VCDDGYTGEDCRDRQCPRDCSNRGLCV--DGQCVCEDGFTGPDCAELS 531

Query: 612 --------------QRICSPGFYGHRCS-QTCPQCVHSSGPCHHITGLCDCLPGFTGALC 656
                         Q +C  GF G  C  Q CP   H  G C  + G C C  GFTG  C
Sbjct: 532 CPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRC--VDGQCICHEGFTGLDC 589

Query: 657 NE-VCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPP 705
            +  CPS            C N G C  +   C C  G+ G DCS+  PP
Sbjct: 590 GQHSCPSD-----------CNNLGQC--VSGRCICNEGYSGEDCSEVSPP 626



 Score =  167 bits (422), Expect = 7e-41
 Identities = 133/416 (31%), Positives = 165/416 (39%), Gaps = 125/416 (30%)

Query: 94  CCPGFYESGEMC-VPHCADKCVH-GRCIAPNTCQCEPGWGGTNCSSA-CDGDHWGPHCTS 150
           C  GF  +G+ C  P C + C + GRC+  N C C+ G+ G +CS   C  D     C  
Sbjct: 270 CHDGF--AGDDCNKPLCLNNCYNRGRCVE-NECVCDEGFTGEDCSELICPND-----CFD 321

Query: 151 RCQCKNGALCNPITGACHCAAGFRG---------------WRCEDR---CEQGTYGNDCH 192
           R +C        I G C+C  GF G                RCE+    C++G  G DC 
Sbjct: 322 RGRC--------INGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCS 373

Query: 193 Q-RC--QCQNGATCDHVTGECRCPPGYTGAFCEDL------------------CPPGKHG 231
           + RC   C N   C  V G C C  G+TGA C +L                  C  G  G
Sbjct: 374 EKRCPADCHNRGRC--VDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTG 431

Query: 232 PQCEQ-RCP--CQNGGVCHHVTGECSCPSGWMGTVCGQ-PCPEGRFGKNCSQECQCHNGG 287
             C Q RCP  C + G C  V G+C C  G+ G  C    CP             CH  G
Sbjct: 432 EDCSQLRCPNDCHSRGRC--VEGKCVCEQGFKGYDCSDMSCPN-----------DCHQHG 478

Query: 288 TCDAATGQCHCSPGYTGERCQD-ECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFA 346
            C    G C C  GYTGE C+D +CP             C N G C  V G C+CE GF 
Sbjct: 479 RC--VNGMCVCDDGYTGEDCRDRQCPR-----------DCSNRGLC--VDGQCVCEDGFT 523

Query: 347 GERCEARLCP-----------------EGLYGIKC-DKRCPCHLENTHSCHPMSGECACK 388
           G  C    CP                 EG  G  C ++RCP        C  + G+C C 
Sbjct: 524 GPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRC--VDGQCICH 581

Query: 389 PGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCP 444
            G++GL C +   P            C N   C  V+G+C C  G+ G DCS   P
Sbjct: 582 EGFTGLDCGQHSCPS----------DCNNLGQC--VSGRCICNEGYSGEDCSEVSP 625



 Score =  131 bits (329), Expect = 4e-30
 Identities = 113/363 (31%), Positives = 141/363 (38%), Gaps = 109/363 (30%)

Query: 541 RCDCSHADGC--HPTTGHCRCLPGWSG------VHCDSVCAEGRWGPNCS---LPCYCKN 589
           R  C+   GC   P TG     P  SG        C  VC  G  GPNCS    P  C  
Sbjct: 137 REQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHL 196

Query: 590 GASCSPDDGICECAPGFRGTTCQR------------------ICSPGFYGHRCS-QTCP- 629
              C   DG C C  GF G  C +                  IC  G+ G  CS + CP 
Sbjct: 197 RGRCI--DGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPV 254

Query: 630 QCVHSSGPCHHITGLCDCLPGFTGALCNE------------------VCPSGRFGKNCAG 671
            C    G C  + GLC C  GF G  CN+                  VC  G  G++C+ 
Sbjct: 255 PCSEEHGTC--VDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSE 312

Query: 672 -IC--TCTNNGTCNPIDRSCQCYPGWIGSDCSQP-CPPAHWGPNCIHTCNCHNGAFCSAY 727
            IC   C + G C  I+ +C C  G+ G DC +P CP A           CH    C   
Sbjct: 313 LICPNDCFDRGRC--INGTCYCEEGFTGEDCGKPTCPHA-----------CHTQGRCE-- 357

Query: 728 DGECKCTPGWTGLYCTQ-RCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHC- 785
           +G+C C  G+ G+ C++ RCP             C N   C  + G+C C  GF G  C 
Sbjct: 358 EGQCVCDEGFAGVDCSEKRCP-----------ADCHNRGRC--VDGRCECDDGFTGADCG 404

Query: 786 EQKCPSGTYGYG-----------------CRQI-C--DCLNNSTCDHITGTCYCSPGWKG 825
           E KCP+G  G+G                 C Q+ C  DC +   C  + G C C  G+KG
Sbjct: 405 ELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRC--VEGKCVCEQGFKG 462

Query: 826 ARC 828
             C
Sbjct: 463 YDC 465



 Score =  130 bits (326), Expect = 9e-30
 Identities = 96/297 (32%), Positives = 127/297 (42%), Gaps = 86/297 (28%)

Query: 91  KSQCCPGFY--ESGEMCVPH-CADKCVHGRCIAPNTCQCEPGWGGTNCSSA-CDGDHWGP 146
           + +C  GF   + GE+  P+ C+    HGRC+    C C+ G+ G +CS   C  D    
Sbjct: 391 RCECDDGFTGADCGELKCPNGCSG---HGRCVN-GQCVCDEGYTGEDCSQLRCPND---- 442

Query: 147 HCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHV 206
            C SR +C        + G C C  GF+G+ C D     +  NDCHQ  +C NG      
Sbjct: 443 -CHSRGRC--------VEGKCVCEQGFKGYDCSDM----SCPNDCHQHGRCVNGM----- 484

Query: 207 TGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCP--CQNGGVCHHVTGECSCPSGWMGTVC 264
              C C  GYTG  C D            ++CP  C N G+C  V G+C C  G+ G  C
Sbjct: 485 ---CVCDDGYTGEDCRD------------RQCPRDCSNRGLC--VDGQCVCEDGFTGPDC 527

Query: 265 GQ------------------PCPEGRFGKNCSQE---CQCHNGGTCDAATGQCHCSPGYT 303
            +                   C EG  GK+C ++     CH  G C    GQC C  G+T
Sbjct: 528 AELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRC--VDGQCICHEGFT 585

Query: 304 GERC-QDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGL 359
           G  C Q  CP             C N G+C  VSG C+C  G++GE C     P+ L
Sbjct: 586 GLDCGQHSCP-----------SDCNNLGQC--VSGRCICNEGYSGEDCSEVSPPKDL 629


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score =  218 bits (556), Expect = 2e-56
 Identities = 212/760 (27%), Positives = 274/760 (36%), Gaps = 220/760 (28%)

Query: 103 EMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCN- 161
           + C+PH    CVHG C  P  C CE  WGG  C    +      +C +   C NG  C+ 
Sbjct: 263 DKCIPHPG--CVHGICNEPWQCLCETNWGGQLCDKDLN------YCGTHQPCLNGGTCSN 314

Query: 162 --PITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGA 219
             P    C C  G+ G  CE   E     + CH R  C+  +    +  EC C PG+TG 
Sbjct: 315 TGPDKYQCSCPEGYSGPNCE-IAEHACLSDPCHNRGSCKETS----LGFECECSPGWTGP 369

Query: 220 FCE---DLCPPGKHGPQCEQRCPCQNGGVCHHVTG--ECSCPSGWMGTVC--------GQ 266
            C    D C P            C +GG C  +    +C CP  W G  C         +
Sbjct: 370 TCSTNIDDCSPNN----------CSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAK 419

Query: 267 PCPE-----------------GRFGKNCS---QEC--QCHNGGTC-DAATG-QCHCSPGY 302
           PC                   G  G+NC     +C  QC N  +C D   G +C C PGY
Sbjct: 420 PCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGY 479

Query: 303 TGERCQ---DECPVGTYGVLCAETCQCVNGGKCYHVSG--ACLCEAGFAGERCEARL--- 354
            G+ C+   DEC           +  C+NGG C +      CLC  GF+G  C+  +   
Sbjct: 480 AGDHCERDIDEC----------ASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYC 529

Query: 355 ---------------------CPEGLYGIKCD------KRCPCHLENT------------ 375
                                CPE   G  C       +  PC + ++            
Sbjct: 530 EPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPE 589

Query: 376 -------------HSCHPMSG---ECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGA 419
                          C   SG    C C  G++G YC+E  +       C+    C+NG 
Sbjct: 590 GVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENIND------CES-NPCRNGG 642

Query: 420 DC-DSVTG-KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPV--DGSCTCKA 475
            C D V   KC C+ G++G  C T        IN  S+  C N   C  +  D  C CK 
Sbjct: 643 TCIDGVNSYKCICSDGWEGAYCET-------NINDCSQNPCHNGGTCRDLVNDFYCDCKN 695

Query: 476 GWHGVDCSIR---CPSGTWGFGCNLTCQCLNGGACNTLDGT--CTCAPGWRGEKCELPCQ 530
           GW G  C  R   C   T          C NGG C        C C  GW G  C +   
Sbjct: 696 GWKGKTCHSRDSQCDEAT----------CNNGGTCYDEGDAFKCMCPGGWEGTTCNIARN 745

Query: 531 DGTYGLNCAERCDCSHADGCHPTTGH---CRCLPGWSGVHCDSVCAEGRWGPNCSLPCYC 587
                  C       H  G     G    C C  GW G     +CA+     +CS P  C
Sbjct: 746 SSCLPNPC-------HNGGTCVVNGESFTCVCKEGWEG----PICAQNT--NDCS-PHPC 791

Query: 588 KNGASCSPDDG--ICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGL- 644
            N  +C   D    CECAPGF G  C+         + C Q+ P C   +     I G  
Sbjct: 792 YNSGTCVDGDNWYRCECAPGFAGPDCR------ININEC-QSSP-CAFGATCVDEINGYR 843

Query: 645 CDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGT-----CNPIDRSCQCYPGWIGSDC 699
           C C PG +GA C EV      G+ C  + +   +G      CN    +CQC  G I   C
Sbjct: 844 CVCPPGHSGAKCQEVS-----GRPCITMGSVIPDGAKWDDDCN----TCQCLNGRIA--C 892

Query: 700 SQP-CPPAHWGPNCIHT--CNCHNGAFC-SAYDGECKCTP 735
           S+  C P    P  +H     C +G  C    D +C   P
Sbjct: 893 SKVWCGPR---PCLLHKGHSECPSGQSCIPILDDQCFVHP 929



 Score =  192 bits (488), Expect = 2e-48
 Identities = 209/793 (26%), Positives = 268/793 (33%), Gaps = 226/793 (28%)

Query: 182 CEQGTYGNDCHQRCQCQNGA----TCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQR 237
           C+   YG  C++ C+ ++       CD   G   C  G+ G  C            C Q 
Sbjct: 187 CDDYYYGFGCNKFCRPRDDFFGHYACDQ-NGNKTCMEGWMGPECNRAI--------CRQG 237

Query: 238 CPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNG---GTCDAATG 294
           C  ++G     + G+C C  GW G  C               +C  H G   G C+    
Sbjct: 238 CSPKHGSC--KLPGDCRCQYGWQGLYC--------------DKCIPHPGCVHGICNEPW- 280

Query: 295 QCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSG---ACLCEAGFAGERCE 351
           QC C   + G+ C  +         C     C+NGG C +       C C  G++G  CE
Sbjct: 281 QCLCETNWGGQLCDKDLNY------CGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE 334

Query: 352 ARLCPEGLYGIKCDKRC---PCHLENTHSCHPMS--GECACKPGWSGLYCN---ETCSPG 403
                        +  C   PCH  N  SC   S   EC C PGW+G  C+   + CSP 
Sbjct: 335 I-----------AEHACLSDPCH--NRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPN 381

Query: 404 FYGEACQQICSCQNGADC-DSVTG-KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKND 461
                     +C +G  C D V G KC C P + G  C            C ++  C N 
Sbjct: 382 ----------NCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDAN------ECEAK-PCVNA 424

Query: 462 AVCSPVDGS--CTCKAGWHGVDCSIR------------------------CPSGTWGFGC 495
             C  +  S  C C  GW G +C I                         CP G  G  C
Sbjct: 425 KSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHC 484

Query: 496 NLTCQ------CLNGGAC-NTLDG-TCTCAPGWRGEKCEL--------PCQDGTYGLNCA 539
                      CLNGG C N ++   C C  G+ G  C+L        PCQ+G    N A
Sbjct: 485 ERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRA 544

Query: 540 ER--CDCSH---ADGCHPTTGHCRCLPGWSGVHCDSVCAEGRW--GPNCSLPCYCKNGAS 592
               C C        C     HCR  P      C    A      G        C     
Sbjct: 545 SDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGK 604

Query: 593 CSPDDG---ICECAPGFRGTTCQR-------------------------ICSPGFYGHRC 624
           C    G    C+C  GF GT C                           ICS G+ G  C
Sbjct: 605 CKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYC 664

Query: 625 SQTCPQC----VHSSGPCHHITG--LCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNN 678
                 C     H+ G C  +     CDC  G+ G  C+          +     TC N 
Sbjct: 665 ETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHS-------RDSQCDEATCNNG 717

Query: 679 GTCNPIDRS--CQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGE---CKC 733
           GTC     +  C C  GW G+ C+          +C+    CHNG  C   +GE   C C
Sbjct: 718 GTCYDEGDAFKCMCPGGWEGTTCN-----IARNSSCLPN-PCHNGGTC-VVNGESFTCVC 770

Query: 734 TPGWTGLYCTQR-------------------------CPLGFYGKDCAL-ICQCQN---- 763
             GW G  C Q                          C  GF G DC + I +CQ+    
Sbjct: 771 KEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCA 830

Query: 764 -GADC-DHISG-QCTCRTGFMGRHCEQKC--PSGTYGY----GCRQICDCLNNSTCDHIT 814
            GA C D I+G +C C  G  G  C++    P  T G     G +   DC   +TC  + 
Sbjct: 831 FGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDC---NTCQCLN 887

Query: 815 GTCYCSPGWKGAR 827
           G   CS  W G R
Sbjct: 888 GRIACSKVWCGPR 900



 Score =  178 bits (452), Expect = 2e-44
 Identities = 197/752 (26%), Positives = 265/752 (35%), Gaps = 212/752 (28%)

Query: 9   LSFICLLLCHWIGTASPLNLED--PNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNW 66
           L F C     W G     N++D  PN CSH  +                    C D++N 
Sbjct: 356 LGFECECSPGWTGPTCSTNIDDCSPNNCSHGGT--------------------CQDLVNG 395

Query: 67  FKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMC---VPHC-ADKCVHGR----C 118
           FKC                         CP  + +G+ C      C A  CV+ +     
Sbjct: 396 FKCV------------------------CPPQW-TGKTCQLDANECEAKPCVNAKSCKNL 430

Query: 119 IAPNTCQCEPGWGGTNCS---SACDGDHWGPHCTSRCQCKNGALCNPITGA--CHCAAGF 173
           IA   C C PGW G NC    + C G           QC+N A C  +     C C  G+
Sbjct: 431 IASYYCDCLPGWMGQNCDININDCLG-----------QCQNDASCRDLVNGYRCICPPGY 479

Query: 174 RGWRCE---DRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCE---DLCPP 227
            G  CE   D C      N C     CQN         +C CP G++G  C+   D C P
Sbjct: 480 AGDHCERDIDECA----SNPCLNGGHCQNEIN----RFQCLCPTGFSGNLCQLDIDYCEP 531

Query: 228 GKHGPQCEQRCPCQNGGVCHHVTGE--CSCPSGWMGTVCGQ--------PC--------- 268
                      PCQNG  C++   +  C CP  + G  C          PC         
Sbjct: 532 N----------PCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVA 581

Query: 269 ------PEGRFGKNCSQECQCHNGGTCDAATG---QCHCSPGYTGERCQDECPVGTYGVL 319
                 PEG      S  C  H  G C + +G    C C+ G+TG  C +        + 
Sbjct: 582 MASNDTPEG-VRYISSNVCGPH--GKCKSQSGGKFTCDCNKGFTGTYCHE-------NIN 631

Query: 320 CAETCQCVNGGKCYH--VSGACLCEAGFAGERCEARL--CPEGLYGIKCDKRCPCHLENT 375
             E+  C NGG C     S  C+C  G+ G  CE  +  C +           PCH  N 
Sbjct: 632 DCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQN----------PCH--NG 679

Query: 376 HSCHPMSGE--CACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADC--DSVTGKCTCA 431
            +C  +  +  C CK GW G  C+   S       C +  +C NG  C  +    KC C 
Sbjct: 680 GTCRDLVNDFYCDCKNGWKGKTCHSRDS------QCDE-ATCNNGGTCYDEGDAFKCMCP 732

Query: 432 PGFKGIDCSTPCPLGTYGINCSSRC---GCKNDAVCSPVDG---SCTCKAGWHGVDCSIR 485
            G++G  C+         I  +S C    C N   C  V+G   +C CK GW G  C+  
Sbjct: 733 GGWEGTTCN---------IARNSSCLPNPCHNGGTC-VVNGESFTCVCKEGWEGPICAQN 782

Query: 486 CPSGTWGFGCNLTCQCLNGGACNTLDG----TCTCAPGWRGEKCELPCQDGTYGLNCAER 541
                    C+    C N G C  +DG     C CAPG+ G  C +        +N  + 
Sbjct: 783 TND------CS-PHPCYNSGTC--VDGDNWYRCECAPGFAGPDCRI-------NINECQS 826

Query: 542 CDCSHADGCHPTTG--HCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGI 599
             C+    C        C C PG SG  C  V   GR  P  ++     +GA    D   
Sbjct: 827 SPCAFGATCVDEINGYRCVCPPGHSGAKCQEV--SGR--PCITMGSVIPDGAKWDDDCNT 882

Query: 600 CECAPGFRGTTCQRI-CSPG----FYGHR---CSQTCPQCVHSSGPCHHITGLCDCLPGF 651
           C+C  G     C ++ C P       GH      Q+C   +      H  TG+ +C    
Sbjct: 883 CQCLNG--RIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSS 940

Query: 652 TGALCNEVCPSGRFGKNCAGICTCTNNGTCNP 683
              +  +      +  NCA I    N    +P
Sbjct: 941 LQPVKTKCTSDSYYQDNCANITFTFNKEMMSP 972



 Score =  136 bits (343), Expect = 1e-31
 Identities = 116/391 (29%), Positives = 151/391 (38%), Gaps = 99/391 (25%)

Query: 484 IRCPSGTWGFGCNLTCQ----CLNGGACNTLDGTCTCAPGWRGEKCELP-CQDGTYGLNC 538
           + C    +GFGCN  C+         AC+  +G  TC  GW G +C    C+ G      
Sbjct: 185 VTCDDYYYGFGCNKFCRPRDDFFGHYACDQ-NGNKTCMEGWMGPECNRAICRQG------ 237

Query: 539 AERCDCSHADGCHPTTGHCRCLPGWSGVHCD----------SVC-------AEGRWGPN- 580
                CS   G     G CRC  GW G++CD           +C        E  WG   
Sbjct: 238 -----CSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQL 292

Query: 581 -------CSLPCYCKNGASCS---PDDGICECAPGFRGTTCQRICSPGFYGHRC-SQTCP 629
                  C     C NG +CS   PD   C C  G+ G  C+         H C S  C 
Sbjct: 293 CDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE------IAEHACLSDPC- 345

Query: 630 QCVHSSGPCHHITGL---CDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDR 686
              H+ G C   T L   C+C PG+TG  C+          +C+    C++ GTC  +  
Sbjct: 346 ---HNRGSCKE-TSLGFECECSPGWTGPTCSTNI------DDCSP-NNCSHGGTCQDLVN 394

Query: 687 --SCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQ 744
              C C P W G  C          P C++  +C N    S Y   C C PGW G    Q
Sbjct: 395 GFKCVCPPQWTGKTCQLDANECEAKP-CVNAKSCKN-LIASYY---CDCLPGWMG----Q 445

Query: 745 RCPLGFYGKDCALICQCQNGADC-DHISG-QCTCRTGFMGRHCEQ---KCPSGTYGYGCR 799
            C +     DC  + QCQN A C D ++G +C C  G+ G HCE+   +C S        
Sbjct: 446 NCDINI--NDC--LGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASN------- 494

Query: 800 QICDCLNNSTCDHITG--TCYCSPGWKGARC 828
               CLN   C +      C C  G+ G  C
Sbjct: 495 ---PCLNGGHCQNEINRFQCLCPTGFSGNLC 522



 Score =  129 bits (323), Expect = 2e-29
 Identities = 146/588 (24%), Positives = 189/588 (32%), Gaps = 185/588 (31%)

Query: 399 TCSPGFYGEACQQICSCQNG----ADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSS 454
           TC   +YG  C + C  ++       CD   G  TC  G+ G +C+           C  
Sbjct: 186 TCDDYYYGFGCNKFCRPRDDFFGHYACDQ-NGNKTCMEGWMGPECNRAI--------CRQ 236

Query: 455 RCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCP-----------------SGTWGFG--- 494
            C  K+ +   P  G C C+ GW G+ C    P                    WG     
Sbjct: 237 GCSPKHGSCKLP--GDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCD 294

Query: 495 -----CNLTCQCLNGGACNTLDG---TCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSH 546
                C     CLNGG C+        C+C  G+ G  CE+  +       C  R  C  
Sbjct: 295 KDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEI-AEHACLSDPCHNRGSCKE 353

Query: 547 ADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCS-----------LPCYCK---NGAS 592
                     C C PGW+G  C S   +     NCS             C C     G +
Sbjct: 354 TS----LGFECECSPGWTGPTC-STNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKT 408

Query: 593 CSPDDGICECAPGFRGTTCQRI-------CSPGFYGHRCSQTCPQCV---HSSGPCHHIT 642
           C  D   CE  P     +C+ +       C PG+ G  C      C+    +   C  + 
Sbjct: 409 CQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLV 468

Query: 643 G--LCDCLPGFTGALC-------------------NEV------CPSGRFGKNC-AGICT 674
               C C PG+ G  C                   NE+      CP+G  G  C   I  
Sbjct: 469 NGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY 528

Query: 675 CTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIH--------------TCN--- 717
           C      NP     QCY     SD    CP  + G NC H              +C    
Sbjct: 529 CEP----NPCQNGAQCYNR--ASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAM 582

Query: 718 ----------------CHNGAFCSAYDG---ECKCTPGWTGLYCTQRCPLGFYGKDCALI 758
                           C     C +  G    C C  G+TG YC +         DC   
Sbjct: 583 ASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENI------NDCE-S 635

Query: 759 CQCQNGADC-DHI-SGQCTCRTGFMGRHCE---QKCPSGTYGYG--CRQI-----CDCLN 806
             C+NG  C D + S +C C  G+ G +CE     C       G  CR +     CDC N
Sbjct: 636 NPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKN 695

Query: 807 ----------NSTCDHIT----GTCY---------CSPGWKGARCDQA 831
                     +S CD  T    GTCY         C  GW+G  C+ A
Sbjct: 696 GWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIA 743


>gi|21264602 laminin alpha 5 [Homo sapiens]
          Length = 3695

 Score =  208 bits (530), Expect = 2e-53
 Identities = 161/526 (30%), Positives = 203/526 (38%), Gaps = 120/526 (22%)

Query: 89  RRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGP-- 146
           RR SQ   G Y+ G +C+                   C+    G NC     G +  P  
Sbjct: 377 RRASQSLDGTYQGGGVCI------------------DCQHHTTGVNCERCLPGFYRSPNH 418

Query: 147 -----HCTSRCQCKNG---ALCNPITGACHCAAGFRGWRCEDRCEQGTYG---------- 188
                H   RC C++      C  +TG C+C   F G RC D C +G  G          
Sbjct: 419 PLDSPHVCRRCNCESDFTDGTCEDLTGRCYCRPNFSGERC-DVCAEGFTGFPSCYPTPSS 477

Query: 189 -NDCHQR---------CQCQ------NGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGP 232
            ND  ++         C C       N    D   G C C P + G  CE LC PG +GP
Sbjct: 478 SNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCE-LCAPGFYGP 536

Query: 233 QCEQRCPCQNGGV----CHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGT 288
            C Q C C + GV    C   TG+C C  G+ G  C + C  G F     Q C C   GT
Sbjct: 537 GC-QPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDR-CAPGYFHFPLCQLCGCSPAGT 594

Query: 289 ----CDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGA---CLC 341
               CD A G+C C P + G  C D C  G +G    + C C   G    + GA   C C
Sbjct: 595 LPEGCDEA-GRCLCQPEFAGPHC-DRCRPGYHGFPNCQACTCDPRGALDQLCGAGGLCRC 652

Query: 342 EAGFAGERCEARLCPEGLYGIKCDKRCPCHLENT--HSCHPMSGECACKPGWSGLYCNET 399
             G+ G  C+   C  G +G      C C  E +   +C P SG+C+C+P  +GL C +T
Sbjct: 653 RPGYTGTACQE--CSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRC-DT 709

Query: 400 CSPGFYG---------------------EACQQICSCQ---NGADCDSVTGKCTCAPGFK 435
           C PG Y                         Q  C C+    G  CD       C PGF 
Sbjct: 710 CVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDR------CKPGFW 763

Query: 436 GIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWG--- 492
           G+  S P   G    +C  R      A C P  G C CK    G  C+  C  G +G   
Sbjct: 764 GLSPSNP--EGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACA-SCKDGFFGLDQ 820

Query: 493 ---FGCNLTCQCLNGGA----CNTLDGTCTCAPGWRGEKCELPCQD 531
              FGC  +C+C  GGA    C    G C C P  +G  C  P +D
Sbjct: 821 ADYFGCR-SCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARD 865



 Score =  193 bits (491), Expect = 7e-49
 Identities = 180/609 (29%), Positives = 223/609 (36%), Gaps = 122/609 (20%)

Query: 194 RCQCQNGATC-------DHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVC 246
           RC C   A         D    +C C     G  C+  CP     P         N    
Sbjct: 299 RCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSAN---- 354

Query: 247 HHVTGEC-SCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGE 305
                EC SC      T C       R   + S +     GG C        C    TG 
Sbjct: 355 -----ECQSCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVC------IDCQHHTTGV 403

Query: 306 RCQDECPVGTY--------GVLCAETCQCVNG---GKCYHVSGACLCEAGFAGERCEARL 354
            C+  C  G Y               C C +    G C  ++G C C   F+GERC+  +
Sbjct: 404 NCE-RCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCRPNFSGERCD--V 460

Query: 355 CPEGLYGIKC---------DKR-----------CPCHLENT--HSCH--PMSGECACKPG 390
           C EG  G            D R           C C    T  ++C   P  G C CKP 
Sbjct: 461 CAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPN 520

Query: 391 WSGLYCNETCSPGFYGEACQQI-CSCQNGAD--CDSVTGKCTCAPGFKGIDCSTPCPLGT 447
           + G +C E C+PGFYG  CQ   CS    AD  CD  TG+C C  GF+G  C   C  G 
Sbjct: 521 FQGTHC-ELCAPGFYGPGCQPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDR-CAPGY 578

Query: 448 YGINCSSRCGCKNDAV----CSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLN 503
           +       CGC         C    G C C+  + G  C  RC  G  GF     C C  
Sbjct: 579 FHFPLCQLCGCSPAGTLPEGCDEA-GRCLCQPEFAGPHCD-RCRPGYHGFPNCQACTCDP 636

Query: 504 GGACNTL---DGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADG-----CHPTTG 555
            GA + L    G C C PG+ G  C+  C  G +G      C CS A+G     C P +G
Sbjct: 637 RGALDQLCGAGGLCRCRPGYTGTACQ-ECSPGFHGFPSCVPCHCS-AEGSLHAACDPRSG 694

Query: 556 HCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSP------DDGI------CECA 603
            C C P  +G+ CD+ C  G +    + P YC+ G SC P      D  +      C C 
Sbjct: 695 QCSCRPRVTGLRCDT-CVPGAY----NFP-YCEAG-SCHPAGLAPVDPALPEAQVPCMCR 747

Query: 604 PGFRGTTCQRICSPGFYG---------HRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGA 654
               G +C R C PGF+G          RCS      +     C   TG C C P   G 
Sbjct: 748 AHVEGPSCDR-CKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQ 806

Query: 655 LCNEVCPSGRFGKNCAGI-----CTCTNNG----TCNPIDRSCQCYPGWIGSDCSQPCPP 705
            C   C  G FG + A       C C   G    +C P    C+C P   G  CS+P   
Sbjct: 807 ACAS-CKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARD 865

Query: 706 AHWGPNCIH 714
            H+ P+  H
Sbjct: 866 -HYLPDLHH 873



 Score =  184 bits (466), Expect = 5e-46
 Identities = 169/586 (28%), Positives = 214/586 (36%), Gaps = 123/586 (20%)

Query: 175 GWRC-----EDRCEQGTYGNDCHQRCQCQN---GATCDHVTGECRCPPGYT--------- 217
           G RC      D C+     +    +C CQ+   G TCD      RC PG+          
Sbjct: 297 GGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCD------RCCPGFNQQPWKPATA 350

Query: 218 -------GAFCEDLCPPGKHGPQCEQRCPCQN-------GGVC----HHVTG-ECS-CPS 257
                     C        + P+ ++R   Q+       GGVC    HH TG  C  C  
Sbjct: 351 NSANECQSCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLP 410

Query: 258 GWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYG 317
           G+  +    P       + C+ E      GTC+  TG+C+C P ++GERC D C  G  G
Sbjct: 411 GFYRSP-NHPLDSPHVCRRCNCESD-FTDGTCEDLTGRCYCRPNFSGERC-DVCAEGFTG 467

Query: 318 V-LCAET-------------------CQC----VNGGKCYHVS--GACLCEAGFAGERCE 351
              C  T                   C C      G  C      G CLC+  F G  CE
Sbjct: 468 FPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCE 527

Query: 352 ARLCPEGLYGIKCDKRCPCHLENT--HSCHPMSGECACKPGWSGLYCNETCSPGFYGEAC 409
             LC  G YG  C + C C         C P +G+C C+ G+ G  C + C+PG++    
Sbjct: 528 --LCAPGFYGPGC-QPCQCSSPGVADDRCDPDTGQCRCRVGFEGATC-DRCAPGYFHFPL 583

Query: 410 QQICSCQNGA----DCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKN----D 461
            Q+C C         CD   G+C C P F G  C   C  G +G      C C      D
Sbjct: 584 CQLCGCSPAGTLPEGCDE-AGRCLCQPEFAGPHCDR-CRPGYHGFPNCQACTCDPRGALD 641

Query: 462 AVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGG----ACNTLDGTCTCA 517
            +C    G C C+ G+ G  C   C  G  GF   + C C   G    AC+   G C+C 
Sbjct: 642 QLCG-AGGLCRCRPGYTGTACQ-ECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCR 699

Query: 518 PGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTG-------HCRCLPGWSGVHCDS 570
           P   G +C+  C  G Y     E   C H  G  P           C C     G  CD 
Sbjct: 700 PRVTGLRCD-TCVPGAYNFPYCEAGSC-HPAGLAPVDPALPEAQVPCMCRAHVEGPSCDR 757

Query: 571 VCAEGRWGPNCSLP-----CYCK------NGASCSPDDGICECAPGFRGTTCQRICSPGF 619
            C  G WG + S P     C C         A C P  G C C P   G  C   C  GF
Sbjct: 758 -CKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACAS-CKDGF 815

Query: 620 YGHRCSQ--TCPQCVHSSG-----PCHHITGLCDCLPGFTGALCNE 658
           +G   +    C  C    G      C   TG+C C P   G  C+E
Sbjct: 816 FGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSE 861



 Score =  172 bits (437), Expect = 1e-42
 Identities = 156/598 (26%), Positives = 211/598 (35%), Gaps = 169/598 (28%)

Query: 367 RCPCHLENTHSCH------PMSGECACKPGWSGLYCNETCSPGFYGEACQ---------- 410
           RC CH  +  +C       P   +C C+    G  C+  C PGF  +  +          
Sbjct: 299 RCVCH-GHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCC-PGFNQQPWKPATANSANEC 356

Query: 411 QICSCQNGA-DC------DSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAV 463
           Q C+C   A DC      D      +    ++G      C   T G+NC         + 
Sbjct: 357 QSCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSP 416

Query: 464 CSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQC---LNGGACNTLDGTCTCAPGW 520
             P+D    C+                        C C      G C  L G C C P +
Sbjct: 417 NHPLDSPHVCRR-----------------------CNCESDFTDGTCEDLTGRCYCRPNF 453

Query: 521 RGEKCELPCQDGTYGL-NCAE-------------------RCDCSHA----DGCH--PTT 554
            GE+C++ C +G  G  +C                      CDCS A    + C   P  
Sbjct: 454 SGERCDV-CAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRV 512

Query: 555 GHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGA----SCSPDDGICECAPGFRGTT 610
           G C C P + G HC+ +CA G +GP C  PC C +       C PD G C C  GF G T
Sbjct: 513 GRCLCKPNFQGTHCE-LCAPGFYGPGCQ-PCQCSSPGVADDRCDPDTGQCRCRVGFEGAT 570

Query: 611 CQRICSPGFYGHRCSQTCPQCVHSSGP--CHHITGLCDCLPGFTGALCNEVCPSGRFGKN 668
           C R C+PG++     Q C      + P  C    G C C P F G  C+   P      N
Sbjct: 571 CDR-CAPGYFHFPLCQLCGCSPAGTLPEGCDE-AGRCLCQPEFAGPHCDRCRPGYHGFPN 628

Query: 669 CAGICTCTNNGTCNPIDRS---CQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNG---- 721
           C   CTC   G  + +  +   C+C PG+ G+ C +  P  H  P+C+  C+C       
Sbjct: 629 CQA-CTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCV-PCHCSAEGSLH 686

Query: 722 AFCSAYDGECKCTPGWTGLYCT-------------------------------------- 743
           A C    G+C C P  TGL C                                       
Sbjct: 687 AACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPCMC 746

Query: 744 ---------QRCPLGFYG------KDCALICQCQ------NGADCDHISGQCTCRTGFMG 782
                     RC  GF+G      + C   C C         A+C   +GQC C+    G
Sbjct: 747 RAHVEGPSCDRCKPGFWGLSPSNPEGCTR-CSCDLRGTLGGVAECQPGTGQCFCKPHVCG 805

Query: 783 RHCEQKCPSGTYG------YGCRQICDC----LNNSTCDHITGTCYCSPGWKGARCDQ 830
           + C   C  G +G      +GCR  C C        +C+  TG C C P  +G  C +
Sbjct: 806 QACAS-CKDGFFGLDQADYFGCRS-CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSE 861



 Score =  143 bits (360), Expect = 1e-33
 Identities = 115/325 (35%), Positives = 136/325 (41%), Gaps = 61/325 (18%)

Query: 296  CHCSPGYTGERCQDECPVGTY----GVLCAET--CQCV-NGGKCYHVSGACL-CEAGFAG 347
            C C   Y G+ CQ EC  G Y    G+       CQC  +  +C   SG C+ C+    G
Sbjct: 1831 CLCPASYRGDSCQ-ECAPGFYRDVKGLFLGRCVPCQCHGHSDRCLPGSGVCVDCQHNTEG 1889

Query: 348  ERCEARLCPEGLYGIKCDKR-----CPCHLEN-----THSCHPMSG--ECACKPGWSGLY 395
              CE   C  G    + D       CPC L          C    G  +C CKPG++G  
Sbjct: 1890 AHCER--CQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCLCKPGYAGAS 1947

Query: 396  CNETCSPGFYGE------ACQQICSCQ-NG------ADCDSVTGKCT-CAPGFKGIDCST 441
            C E C+PGF+G       +CQ  C C  NG      +DCD +TG C  C     G  C  
Sbjct: 1948 C-ERCAPGFFGNPLVLGSSCQP-CDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEI 2005

Query: 442  PCPLGTYGI-----NCSSRCGCK--NDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGF- 493
             C  G YG      NC+ RC C       C P  G C CKAG  G  C  RC  G +GF 
Sbjct: 2006 -CAPGFYGNALLPGNCT-RCDCTPCGTEACDPHSGHCLCKAGVTGRRCD-RCQEGHFGFD 2062

Query: 494  ---GCNLTCQC---LNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGL--NCAERCDCS 545
               GC   C C     G  C+   G C C PG  G +C   C  G +GL      RC C 
Sbjct: 2063 GCGGCR-PCACGPAAEGSECHPQSGQCHCRPGTMGPQCR-ECAPGYWGLPEQGCRRCQCP 2120

Query: 546  HADGCHPTTGHCRCLPGWSGVHCDS 570
                C P TG C C PG SG  CD+
Sbjct: 2121 -GGRCDPHTGRCNCPPGLSGERCDT 2144



 Score =  132 bits (332), Expect = 2e-30
 Identities = 126/460 (27%), Positives = 168/460 (36%), Gaps = 99/460 (21%)

Query: 423 SVTGKCTCAPGFKGIDCSTP---------CPLGTYGINCSSRCGCKNDAVCSPVDGSC-- 471
           S+ G+C C       D   P         C   T G  C   C   N     P   +   
Sbjct: 295 SIGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSAN 354

Query: 472 ---TCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELP 528
              +C    H  DC                 +     A  +LDGT      ++G    + 
Sbjct: 355 ECQSCNCYGHATDCYY-------------DPEVDRRRASQSLDGT------YQGGGVCID 395

Query: 529 CQDGTYGLNC--------------------AERCDCSH--ADG-CHPTTGHCRCLPGWSG 565
           CQ  T G+NC                      RC+C     DG C   TG C C P +SG
Sbjct: 396 CQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCRPNFSG 455

Query: 566 VHCDSVCAEGRWG-PNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSP-GFYGHR 623
             CD VCAEG  G P+C            S +D   +  P  +   C   CS  G  G+ 
Sbjct: 456 ERCD-VCAEGFTGFPSCY-------PTPSSSNDTREQVLPAGQIVNCD--CSAAGTQGNA 505

Query: 624 CSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGT--- 680
           C +  P+            G C C P F G  C E+C  G +G  C   C C++ G    
Sbjct: 506 CRKD-PR-----------VGRCLCKPNFQGTHC-ELCAPGFYGPGCQP-CQCSSPGVADD 551

Query: 681 -CNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHN-GAFCSAYD--GECKCTPG 736
            C+P    C+C  G+ G+ C + C P ++       C C   G      D  G C C P 
Sbjct: 552 RCDPDTGQCRCRVGFEGATCDR-CAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPE 610

Query: 737 WTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQ---CTCRTGFMGRHCEQKCPSGT 793
           + G +C  RC  G++G      C C      D + G    C CR G+ G  C Q+C  G 
Sbjct: 611 FAGPHC-DRCRPGYHGFPNCQACTCDPRGALDQLCGAGGLCRCRPGYTGTAC-QECSPGF 668

Query: 794 YGYGCRQICDCLN----NSTCDHITGTCYCSPGWKGARCD 829
           +G+     C C      ++ CD  +G C C P   G RCD
Sbjct: 669 HGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCD 708



 Score =  123 bits (309), Expect = 9e-28
 Identities = 112/358 (31%), Positives = 142/358 (39%), Gaps = 69/358 (19%)

Query: 157  GALCNPITGACHCAAGFRGWRCED------RCEQGTYGNDCHQRCQCQNGATCDHVTGEC 210
            GAL + +   C C A +RG  C++      R  +G +   C   CQC   +         
Sbjct: 1822 GALASNVE-LCLCPASYRGDSCQECAPGFYRDVKGLFLGRCVP-CQCHGHSD-------- 1871

Query: 211  RCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPE 270
            RC PG     C D C     G  CE+   CQ G V         C S      C  PCP 
Sbjct: 1872 RCLPG--SGVCVD-CQHNTEGAHCER---CQAGFVSSRDDPSAPCVS------C--PCPL 1917

Query: 271  GRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYG---VL--CAETCQ 325
                 N ++ C    G T      QC C PGY G  C+  C  G +G   VL    + C 
Sbjct: 1918 SVPSNNFAEGCVLRGGRT------QCLCKPGYAGASCE-RCAPGFFGNPLVLGSSCQPCD 1970

Query: 326  CVNGGK-------CYHVSGACL-CEAGFAGERCEARLCPEGLYGI-----KCDKRCPCHL 372
            C   G        C  ++GAC  C     G RCE  +C  G YG       C  RC C  
Sbjct: 1971 CSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCE--ICAPGFYGNALLPGNCT-RCDCTP 2027

Query: 373  ENTHSCHPMSGECACKPGWSGLYCNETCSPGFYG-EACQ--QICSC---QNGADCDSVTG 426
              T +C P SG C CK G +G  C + C  G +G + C   + C+C     G++C   +G
Sbjct: 2028 CGTEACDPHSGHCLCKAGVTGRRC-DRCQEGHFGFDGCGGCRPCACGPAAEGSECHPQSG 2086

Query: 427  KCTCAPGFKGIDCSTPCPLGTYGI--NCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDC 482
            +C C PG  G  C   C  G +G+      RC C     C P  G C C  G  G  C
Sbjct: 2087 QCHCRPGTMGPQC-RECAPGYWGLPEQGCRRCQCPGGR-CDPHTGRCNCPPGLSGERC 2142



 Score =  122 bits (307), Expect = 1e-27
 Identities = 104/324 (32%), Positives = 131/324 (40%), Gaps = 62/324 (19%)

Query: 557  CRCLPGWSGVHCDSVCAEGRWGPNCSL------PCYCKNGAS-CSPDDGIC-ECAPGFRG 608
            C C   + G  C   CA G +     L      PC C   +  C P  G+C +C     G
Sbjct: 1831 CLCPASYRGDSCQE-CAPGFYRDVKGLFLGRCVPCQCHGHSDRCLPGSGVCVDCQHNTEG 1889

Query: 609  TTCQRICSPGFYGHRCSQTCPQCVHSSGPC-------HHITGL--------CDCLPGFTG 653
              C+R C  GF   R   + P CV  S PC       +   G         C C PG+ G
Sbjct: 1890 AHCER-CQAGFVSSRDDPSAP-CV--SCPCPLSVPSNNFAEGCVLRGGRTQCLCKPGYAG 1945

Query: 654  ALCNEVCPSGRFGK-----NCAGICTCTNNGT-------CNPIDRSCQ-CYPGWIGSDCS 700
            A C E C  G FG      +    C C+ NG        C+P+  +C+ C     G  C 
Sbjct: 1946 ASC-ERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRC- 2003

Query: 701  QPCPPAHWG----PNCIHTCNCH--NGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKD 754
            + C P  +G    P     C+C       C  + G C C  G TG  C  RC  G +G D
Sbjct: 2004 EICAPGFYGNALLPGNCTRCDCTPCGTEACDPHSGHCLCKAGVTGRRC-DRCQEGHFGFD 2062

Query: 755  CALICQ------CQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYG---YGCRQICDCL 805
                C+         G++C   SGQC CR G MG  C ++C  G +G    GCR+ C C 
Sbjct: 2063 GCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQC-RECAPGYWGLPEQGCRR-CQC- 2119

Query: 806  NNSTCDHITGTCYCSPGWKGARCD 829
                CD  TG C C PG  G RCD
Sbjct: 2120 PGGRCDPHTGRCNCPPGLSGERCD 2143



 Score =  115 bits (288), Expect = 2e-25
 Identities = 81/216 (37%), Positives = 98/216 (45%), Gaps = 35/216 (16%)

Query: 124  CQCEPGWGGTNCSSACDGDHWGP----HCTSRCQCK-NG------ALCNPITGACH-CAA 171
            C C+PG+ G +C     G    P         C C  NG      + C+P+TGAC  C  
Sbjct: 1937 CLCKPGYAGASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLR 1996

Query: 172  GFRGWRCEDRCEQGTYGN-----DCHQRCQCQNGAT--CDHVTGECRCPPGYTGAFCEDL 224
               G RCE  C  G YGN     +C  RC C    T  CD  +G C C  G TG  C D 
Sbjct: 1997 HTTGPRCEI-CAPGFYGNALLPGNC-TRCDCTPCGTEACDPHSGHCLCKAGVTGRRC-DR 2053

Query: 225  CPPGKHGPQCEQRC------PCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFG---K 275
            C  G  G      C      P   G  CH  +G+C C  G MG  C + C  G +G   +
Sbjct: 2054 CQEGHFGFDGCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCRE-CAPGYWGLPEQ 2112

Query: 276  NCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDEC 311
             C + CQC  GG CD  TG+C+C PG +GERC D C
Sbjct: 2113 GC-RRCQCP-GGRCDPHTGRCNCPPGLSGERC-DTC 2145



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 70/223 (31%), Positives = 88/223 (39%), Gaps = 35/223 (15%)

Query: 633  HSSGPCHHITGLCDCLPGFTGALCNEVCPS-GRFGKNCAGICTCTNNG----TCNPIDRS 687
            H +   +HI+      P  +   C     S   F  N A  C C   G    TC P    
Sbjct: 1403 HCAAQGYHIS------PSSSSLFCRNAAASLSLFYNNGARPCGCHEVGATGPTCEPFGGQ 1456

Query: 688  CQCYPGWIGSDCSQPCPPAHWG-PNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRC 746
            C C+   IG DCS+ C   +WG PNC   C+C     C    G+C C P      C    
Sbjct: 1457 CPCHAHVIGRDCSR-CATGYWGFPNC-RPCDC-GARLCDELTGQCICPPRTIPPDCLLCQ 1513

Query: 747  PLGFYGKDCALICQCQN------------GADCDHISGQCTCRTGFMGRHCEQKCPSGTY 794
            P  F    C  +  C+                CD  SGQC CR    GR C+  C  G +
Sbjct: 1514 PQTF---GCHPLVGCEECNCSGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDT-CSPGFH 1569

Query: 795  GYGCRQICDCLNNST----CDHITGTCYCSPGWKGARCDQAGV 833
            GY   + CDC    T    CD +TG CYC    +G +CDQ  +
Sbjct: 1570 GYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSL 1612



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 77/254 (30%), Positives = 96/254 (37%), Gaps = 47/254 (18%)

Query: 431  APGFKGIDC-STPCPLGTYGINCSSRCGCKN----DAVCSPVDGSCTCKAGWHGVDCSIR 485
            +P    + C +    L  +  N +  CGC         C P  G C C A   G DCS R
Sbjct: 1412 SPSSSSLFCRNAAASLSLFYNNGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCS-R 1470

Query: 486  CPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCS 545
            C +G WGF     C C     C+ L G C C P      C L CQ  T+G          
Sbjct: 1471 CATGYWGFPNCRPCDC-GARLCDELTGQCICPPRTIPPDCLL-CQPQTFG---------- 1518

Query: 546  HADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCK-NGASCSPDDGICECAP 604
                CHP  G   C                    NCS P   +    +C  D G C+C P
Sbjct: 1519 ----CHPLVGCEEC--------------------NCSGPGIQELTDPTCDTDSGQCKCRP 1554

Query: 605  GFRGTTCQRICSPGFYGH-RCSQT-CPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPS 662
               G  C   CSPGF+G+ RC    C +   + G C  +TG C C     G  C++ C  
Sbjct: 1555 NVTGRRCDT-CSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQ-CSL 1612

Query: 663  GRFGKNCAGICTCT 676
            G F  + A    CT
Sbjct: 1613 GTFSLDAANPKGCT 1626



 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 68/211 (32%), Positives = 84/211 (39%), Gaps = 33/211 (15%)

Query: 157  GALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGY 216
            G  C P  G C C A   G  C  RC  G +G    + C C     CD +TG+C CPP  
Sbjct: 1447 GPTCEPFGGQCPCHAHVIGRDC-SRCATGYWGFPNCRPCDC-GARLCDELTGQCICPPRT 1504

Query: 217  TGAFCEDLCPPGKHGPQ----CEQRCPCQNGGV-------CHHVTGECSCPSGWMGTVCG 265
                C  LC P   G      CE+ C C   G+       C   +G+C C     G  C 
Sbjct: 1505 IPPDCL-LCQPQTFGCHPLVGCEE-CNCSGPGIQELTDPTCDTDSGQCKCRPNVTGRRC- 1561

Query: 266  QPCPEGRFGKNCSQECQCHNGGT----CDAATGQCHCSPGYTGERCQDECPVGTYGVLCA 321
              C  G  G    + C CH  GT    CD  TGQC+C     G +C D+C +GT+ +  A
Sbjct: 1562 DTCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKC-DQCSLGTFSLDAA 1620

Query: 322  ETCQCVNGGKCYHVSGACLCEAGFAGERCEA 352
                C            C C    A ERC +
Sbjct: 1621 NPKGCTR----------CFCFG--ATERCRS 1639



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 61/203 (30%), Positives = 87/203 (42%), Gaps = 24/203 (11%)

Query: 273  FGKNCSQECQCHN----GGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVN 328
            F  N ++ C CH     G TC+   GQC C     G  C   C  G +G      C C  
Sbjct: 1430 FYNNGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCS-RCATGYWGFPNCRPCDC-G 1487

Query: 329  GGKCYHVSGACLCEAGFAGERCEARLCPEGLYG----IKCDKRCPCHLENTH-----SCH 379
               C  ++G C+C        C   LC    +G    + C++ C C           +C 
Sbjct: 1488 ARLCDELTGQCICPPRTIPPDC--LLCQPQTFGCHPLVGCEE-CNCSGPGIQELTDPTCD 1544

Query: 380  PMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGAD----CDSVTGKCTCAPGFK 435
              SG+C C+P  +G  C +TCSPGF+G    + C C         CD +TG+C C    +
Sbjct: 1545 TDSGQCKCRPNVTGRRC-DTCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQ 1603

Query: 436  GIDCSTPCPLGTYGINCSSRCGC 458
            G  C   C LGT+ ++ ++  GC
Sbjct: 1604 GPKCDQ-CSLGTFSLDAANPKGC 1625



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 78/255 (30%), Positives = 101/255 (39%), Gaps = 54/255 (21%)

Query: 599  ICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNE 658
            +C C   +RG +CQ  C+PGFY         +CV    PC        CLPG        
Sbjct: 1830 LCLCPASYRGDSCQE-CAPGFYRDVKGLFLGRCV----PCQCHGHSDRCLPG-------- 1876

Query: 659  VCPSGRFGKNCAGICT-CTNNGTCNPIDRSCQCYPGWIGS--DCSQPCPPAHWGPNCIHT 715
                       +G+C  C +N      +R   C  G++ S  D S PC      P  + +
Sbjct: 1877 -----------SGVCVDCQHNTEGAHCER---CQAGFVSSRDDPSAPCVSCPC-PLSVPS 1921

Query: 716  CNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQ------NG----- 764
             N   G        +C C PG+ G  C +RC  GF+G    L   CQ      NG     
Sbjct: 1922 NNFAEGCVLRGGRTQCLCKPGYAGASC-ERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLL 1980

Query: 765  -ADCDHISGQCT-CRTGFMGRHCEQKCPSGTYGYG-----CRQICDCLNNST--CDHITG 815
             +DCD ++G C  C     G  CE  C  G YG       C + CDC    T  CD  +G
Sbjct: 1981 FSDCDPLTGACRGCLRHTTGPRCEI-CAPGFYGNALLPGNCTR-CDCTPCGTEACDPHSG 2038

Query: 816  TCYCSPGWKGARCDQ 830
             C C  G  G RCD+
Sbjct: 2039 HCLCKAGVTGRRCDR 2053



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 64/206 (31%), Positives = 82/206 (39%), Gaps = 31/206 (15%)

Query: 189  NDCHQRCQCQN----GATCDHVTGECRCPPGYTGAFCEDLCPPGKHG-PQCEQRCPCQNG 243
            N+  + C C      G TC+   G+C C     G  C   C  G  G P C    PC  G
Sbjct: 1432 NNGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSR-CATGYWGFPNCR---PCDCG 1487

Query: 244  G-VCHHVTGECSCPSGWMGTVC--GQPCPEGRFGKNCSQECQCHNGG-------TCDAAT 293
              +C  +TG+C CP   +   C   QP   G       +EC C   G       TCD  +
Sbjct: 1488 ARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDS 1547

Query: 294  GQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGK----CYHVSGACLCEAGFAGER 349
            GQC C P  TG RC D C  G +G      C C   G     C  ++G C C+    G +
Sbjct: 1548 GQCKCRPNVTGRRC-DTCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPK 1606

Query: 350  CEARLCPEGLYGI-----KCDKRCPC 370
            C+   C  G + +     K   RC C
Sbjct: 1607 CDQ--CSLGTFSLDAANPKGCTRCFC 1630



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 69/221 (31%), Positives = 86/221 (38%), Gaps = 29/221 (13%)

Query: 101  SGEMCVPHCADKCVHGRCIAPNTCQCEPG-WGGTNCSSACDGDHWGPHCTSRCQCK---- 155
            +G  C P       H   I  +  +C  G WG  NC     G       T +C C     
Sbjct: 1446 TGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQCICPPRTI 1505

Query: 156  --NGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCP 213
              +  LC P T  CH   G     CE+ C     G       Q     TCD  +G+C+C 
Sbjct: 1506 PPDCLLCQPQTFGCHPLVG-----CEE-CNCSGPG------IQELTDPTCDTDSGQCKCR 1553

Query: 214  PGYTGAFCEDLCPPGKHG-PQCEQRCPCQNG----GVCHHVTGECSCPSGWMGTVCGQPC 268
            P  TG  C D C PG HG P+C + C C       GVC  +TG+C C     G  C Q C
Sbjct: 1554 PNVTGRRC-DTCSPGFHGYPRC-RPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQ-C 1610

Query: 269  PEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQD 309
              G F  + +    C     C  AT +C  S  YT +   D
Sbjct: 1611 SLGTFSLDAANPKGC-TRCFCFGATERCR-SSSYTRQEFVD 1649



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 54/190 (28%), Positives = 70/190 (36%), Gaps = 28/190 (14%)

Query: 321  AETCQC----VNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTH 376
            A  C C      G  C    G C C A   G  C    C  G +G    + C C      
Sbjct: 1435 ARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSR--CATGYWGFPNCRPCDC---GAR 1489

Query: 377  SCHPMSGECACKPGWSGLYCNETCSPGFYG----EACQQICSCQNGA-------DCDSVT 425
             C  ++G+C C P      C   C P  +G      C++ C+C            CD+ +
Sbjct: 1490 LCDELTGQCICPPRTIPPDCL-LCQPQTFGCHPLVGCEE-CNCSGPGIQELTDPTCDTDS 1547

Query: 426  GKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKN----DAVCSPVDGSCTCKAGWHGVD 481
            G+C C P   G  C T C  G +G      C C        VC P+ G C CK    G  
Sbjct: 1548 GQCKCRPNVTGRRCDT-CSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPK 1606

Query: 482  CSIRCPSGTW 491
            C  +C  GT+
Sbjct: 1607 CD-QCSLGTF 1615



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 42/131 (32%), Positives = 51/131 (38%), Gaps = 24/131 (18%)

Query: 89   RRKSQCCPGFY--ESGEMCVPHCADKCVHGRCIAPNT--CQCEPGWGGTNCSSACDGDHW 144
            RR  +C  G +  +    C P        G    P +  C C PG  G  C     G +W
Sbjct: 2049 RRCDRCQEGHFGFDGCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCRECAPG-YW 2107

Query: 145  G--PHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQ--------GTYGNDCHQR 194
            G       RCQC  G  C+P TG C+C  G  G RC D C Q        G  G+  H  
Sbjct: 2108 GLPEQGCRRCQCPGGR-CDPHTGRCNCPPGLSGERC-DTCSQQHQVPVPGGPVGHSIH-- 2163

Query: 195  CQCQNGATCDH 205
            C+      CDH
Sbjct: 2164 CE-----VCDH 2169



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 36/130 (27%), Positives = 49/130 (37%), Gaps = 23/130 (17%)

Query: 93  QCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWG---------GTNCSSACDG-- 141
           +C PGF+         C       R       +C+PG G         G  C+S  DG  
Sbjct: 757 RCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACASCKDGFF 816

Query: 142 -----DHWGPHCTSRCQCK-NGAL---CNPITGACHCAAGFRGWRCEDRCEQGTYGNDCH 192
                D++G  C S C+C   GAL   C P TG C C    +G  C +        +  H
Sbjct: 817 GLDQADYFG--CRS-CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHYLPDLHH 873

Query: 193 QRCQCQNGAT 202
            R + +  AT
Sbjct: 874 LRLELEEAAT 883



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 36/130 (27%), Positives = 48/130 (36%), Gaps = 24/130 (18%)

Query: 731  CKCTPGWTGLYCTQRCPLGFYGKDCALI------CQCQNGAD-CDHISGQCT-CRTGFMG 782
            C C   + G  C Q C  GFY     L       CQC   +D C   SG C  C+    G
Sbjct: 1831 CLCPASYRGDSC-QECAPGFYRDVKGLFLGRCVPCQCHGHSDRCLPGSGVCVDCQHNTEG 1889

Query: 783  RHCEQKCPSGTYGYGCRQICDCLN---------NSTCDHIT-----GTCYCSPGWKGARC 828
             HCE +C +G           C++         N+  +          C C PG+ GA C
Sbjct: 1890 AHCE-RCQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCLCKPGYAGASC 1948

Query: 829  DQAGVIIVGN 838
            ++      GN
Sbjct: 1949 ERCAPGFFGN 1958


>gi|122937283 6720455I24Rik homolog [Homo sapiens]
          Length = 1413

 Score =  206 bits (524), Expect = 1e-52
 Identities = 199/705 (28%), Positives = 255/705 (36%), Gaps = 188/705 (26%)

Query: 109 CADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGA-- 166
           C D CV G      TC C  G+ G  C    +       C S+  C+NG  C     +  
Sbjct: 284 CIDDCVTGN--PSYTCSCLSGFTGRRCHLDVN------ECASQ-PCQNGGTCTHGINSFR 334

Query: 167 CHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGE--CRCPPGYTGAFCE-- 222
           C C AGF G  CE      T  + C  + +CQ+G  C    G   C C  GYTGA CE  
Sbjct: 335 CQCPAGFGGPTCE------TAQSPCDTK-ECQHGGQCQVENGSAVCVCQAGYTGAACEMD 387

Query: 223 -DLCPPGKHGPQCEQRCPCQNGGVCHHVTGE--CSCPSGWMGTVC---GQPCPEGRFGKN 276
            D C P           PC NGG C  + G   C C   + G  C     P P+      
Sbjct: 388 VDDCSPD----------PCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPD------ 431

Query: 277 CSQECQCHNGGTC-DAATGQ-CHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYH 334
                 CHNGGTC DA  G  C C  G+ G  C++  P         + C+C NGG+C  
Sbjct: 432 ACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVP---------DDCECRNGGRCLG 482

Query: 335 VSGA-CLCEAGFAGERCEARL----------CPEGLYGIK--CDKRCPCHLENTHSCHPM 381
            +   C C  GF G  CE  +          CP+G Y ++      C CH ++  S H +
Sbjct: 483 ANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNAS-HSL 541

Query: 382 SGECACKPGWSGLYCNE-------TCSPGFYGEACQQ----ICS---CQNGADCDSVTGK 427
              C   P ++G  C+         C  GF+G+ C++    +CS   C+NG  C    G+
Sbjct: 542 PSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGE 601

Query: 428 --CTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDG--SCTCKAGWHGVDCS 483
             C+C   F G  C    P      +C+S   C N   C    G   C C  G+ G  C 
Sbjct: 602 YHCSCPYRFTGRHCEIGKP-----DSCASG-PCHNGGTCFHYIGKYKCDCPPGFSGRHCE 655

Query: 484 IRCPSGTWGFGCNLTCQCLNGGACNTLDGT--CTCAPGWRGEKC--ELPCQ--------- 530
           I  PS  +         C+NGG C   D    C C  G+ G +C  E+ C          
Sbjct: 656 I-APSPCF------RSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHAT 708

Query: 531 ----------------DGTYGLNCAERC------------------------DCSHADGC 550
                           D  Y L+   R                          C H   C
Sbjct: 709 LRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSC 768

Query: 551 HPTTGH--CRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRG 608
                   C C  G+ G HC+    E R  P       C+NG SC    G   C      
Sbjct: 769 QDRVAGYLCLCSTGYEGAHCELERDECRAHP-------CRNGGSCRNLPGAYVCR----- 816

Query: 609 TTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKN 668
                 C  GF G  C      C   S PC H  G C+   G    LC  VCP   FG +
Sbjct: 817 ------CPAGFVGVHCETEVDAC--DSSPCQH-GGRCE--SGGGAYLC--VCPESFFGYH 863

Query: 669 CAGI------CTCTNNGTC--NPIDRSCQCYPGWIGSDCSQPCPP 705
           C  +        C   G C  +    SC C  G+ G DC++   P
Sbjct: 864 CETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFP 908



 Score =  199 bits (505), Expect = 2e-50
 Identities = 197/693 (28%), Positives = 242/693 (34%), Gaps = 215/693 (31%)

Query: 283 CHNGGTC--DAATGQ----CHCSPGYTGERCQ---DECPVGTYGVLCAETCQCVNGGKCY 333
           C NGG C  D  TG     C C  G+TG RC    +EC         ++ CQ  NGG C 
Sbjct: 278 CLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNEC--------ASQPCQ--NGGTCT 327

Query: 334 HV--SGACLCEAGFAGERCEARLCPEGLYGIKCD-KRCP----CHLENTHSCHPMSGECA 386
           H   S  C C AGF G  CE    P       CD K C     C +EN       S  C 
Sbjct: 328 HGINSFRCQCPAGFGGPTCETAQSP-------CDTKECQHGGQCQVENG------SAVCV 374

Query: 387 CKPGWSGLYCN---ETCSPGFYGEACQQICSCQNGADCDSVTGK--CTCAPGFKGIDCST 441
           C+ G++G  C    + CSP            C NG  C  + G   C CA  FKG+ C T
Sbjct: 375 CQAGYTGAACEMDVDDCSPD----------PCLNGGSCVDLVGNYTCLCAEPFKGLRCET 424

Query: 442 ---PCPLGTYGINCSSRCGCKNDAVCSPVDGS--CTCKAGWHGVDCSIRCPSGTWGFGCN 496
              P P      +      C N   C   D    C C  G+ G+DC  R P         
Sbjct: 425 GDHPVP------DACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDD------- 471

Query: 497 LTCQCLNGGACNTLDGT-CTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTG 555
             C+C NGG C   + T C C  G+ G  CE         + C     C     C    G
Sbjct: 472 --CECRNGGRCLGANTTLCQCPLGFFGLLCEFEIT----AMPCNMNTQCPDGGYCMEHGG 525

Query: 556 HCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDG--ICECAPGFRGTTCQR 613
              C+      H D   +     P  S PC+  NG SC   D    CEC  GF G  C++
Sbjct: 526 SYLCV-----CHTDHNASHSLPSPCDSDPCF--NGGSCDAHDDSYTCECPRGFHGKHCEK 578

Query: 614 ----ICSPG----------------------FYGHRCSQTCPQCVHSSGPCH------HI 641
               +CS G                      F G  C    P    +SGPCH      H 
Sbjct: 579 ARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSC-ASGPCHNGGTCFHY 637

Query: 642 TGL--CDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRS--CQCYPGWIGS 697
            G   CDC PGF+G  C E+ PS  F         C N GTC   D    C C  G++G 
Sbjct: 638 IGKYKCDCPPGFSGRHC-EIAPSPCFRS------PCVNGGTCEDRDTDFFCHCQAGYMGR 690

Query: 698 ------DCSQPCPPAHW------------------------GPNCIHTCNCHN----GAF 723
                 DC  P    H                          P+ I  C  H        
Sbjct: 691 RCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQ 750

Query: 724 CSAYDGECKCTPGWTGLYCTQR-------CPLGFYGKDCALI---CQ---CQNGADCDHI 770
           C   D EC+  P   G  C  R       C  G+ G  C L    C+   C+NG  C ++
Sbjct: 751 CLEID-ECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNL 809

Query: 771 SGQ--CTCRTGFMGRHCEQK-------------------------CPSGTYGYGCRQICD 803
            G   C C  GF+G HCE +                         CP   +GY C  + D
Sbjct: 810 PGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSD 869

Query: 804 CLNNSTC--------DHITGTCYCSPGWKGARC 828
              +S C         + + +C C  G+ G  C
Sbjct: 870 PCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDC 902



 Score =  151 bits (381), Expect = 4e-36
 Identities = 140/515 (27%), Positives = 183/515 (35%), Gaps = 165/515 (32%)

Query: 100 ESGEMCVPH-CADKCVH--GRCIAPN---TCQCEPGWGGTNCSSACDGDHWGPHCTSRCQ 153
           E+G+  VP  C     H  G C+  +    C+C  G+ G +C      D         C+
Sbjct: 423 ETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDD---------CE 473

Query: 154 CKNGALC-NPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATC--------- 203
           C+NG  C    T  C C  GF G  CE           C+   QC +G  C         
Sbjct: 474 CRNGGRCLGANTTLCQCPLGFFGLLCEFEIT----AMPCNMNTQCPDGGYCMEHGGSYLC 529

Query: 204 ----DH-----VTGECRCPPGYTGAFCEDL-------CPPGKHGPQCEQR----C---PC 240
               DH     +   C   P + G  C+         CP G HG  CE+     C   PC
Sbjct: 530 VCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPC 589

Query: 241 QNGGVCHHVTGE--CSCPSGWMGTVC--GQP--CPEGRFGKNCSQECQCHNGGTCDAATG 294
           +NGG C    GE  CSCP  + G  C  G+P  C  G           CHNGGTC    G
Sbjct: 590 RNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASG----------PCHNGGTCFHYIG 639

Query: 295 Q--CHCSPGYTGERCQDECPVGTYGVLCAETC---QCVNGGKCYH--VSGACLCEAGFAG 347
           +  C C PG++G  C+          +    C    CVNGG C        C C+AG+ G
Sbjct: 640 KYKCDCPPGFSGRHCE----------IAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMG 689

Query: 348 ERCEARL---------------------------CPEGLYGIKCDKRCP-CHLENTHSCH 379
            RC+A +                           C  G Y +    R   C      S  
Sbjct: 690 RRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRG-YSLSAPSRIRVCQPHGVWSEP 748

Query: 380 PMS---GECACKPGWSGLYCNET-------CSPGFYGEACQ------QICSCQNGADCDS 423
           P      EC  +P   G  C +        CS G+ G  C+      +   C+NG  C +
Sbjct: 749 PQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRN 808

Query: 424 VTGK--CTCAPGFKGIDCSTP-------------------------CPLGTYGINC---- 452
           + G   C C  GF G+ C T                          CP   +G +C    
Sbjct: 809 LPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVS 868

Query: 453 ----SSRCGCKNDAVCSPVDGSCTCKAGWHGVDCS 483
               SS CG +   + S    SCTCK G+ G DC+
Sbjct: 869 DPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCA 903



 Score =  100 bits (249), Expect = 8e-21
 Identities = 113/443 (25%), Positives = 142/443 (32%), Gaps = 132/443 (29%)

Query: 15  LLCHWIGTASPLNLE----DPNVC-SHWESYSVT------VQESYPHPFDQIYYTSCTDI 63
           LLC +  TA P N+     D   C  H  SY            S P P D          
Sbjct: 497 LLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDS------DPC 550

Query: 64  LNWFKCTRHRVSYRTAYR---HGEKTMYRRKSQCCPGFYESGEMCVP-----HCA----- 110
            N   C  H  SY        HG+     R   C  G   +G  C       HC+     
Sbjct: 551 FNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRF 610

Query: 111 ----------DKCVHGRC---------IAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSR 151
                     D C  G C         I    C C PG+ G +C  A       P    R
Sbjct: 611 TGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIA-------PSPCFR 663

Query: 152 CQCKNGALCNP--ITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQ------------- 196
             C NG  C        CHC AG+ G RC+   + G      H   +             
Sbjct: 664 SPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYA 723

Query: 197 CQNGATCDHVT--------------------GECRCPPGYTGAFCED-------LCPPGK 229
           C  G +    +                     ECR  P   G  C+D       LC  G 
Sbjct: 724 CDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGY 783

Query: 230 HGPQCE---QRC---PCQNGGVCHHVTGE--CSCPSGWMGTVCGQPCPEGRFGKNCSQEC 281
            G  CE     C   PC+NGG C ++ G   C CP+G++G  C           +     
Sbjct: 784 EGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEV-------DACDSS 836

Query: 282 QCHNGGTCDAATGQ--CHCSPGYTGERCQ---DEC---PVGTYGVLCAETCQCVNGGKCY 333
            C +GG C++  G   C C   + G  C+   D C   P G  G      C   NG    
Sbjct: 837 PCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGY-----CLASNG---- 887

Query: 334 HVSGACLCEAGFAGERCEARLCP 356
             S +C C+ G+ GE C   L P
Sbjct: 888 --SHSCTCKVGYTGEDCAKELFP 908



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 8/61 (13%)

Query: 587  CKNGASCSP--DDGICECAPGFRGTTCQRICSPGFYGHRC----SQTCPQCVHSSGPCHH 640
            C+NG +C P  D   C+C PGF+G  C+  C        C    S+T    V   G CHH
Sbjct: 1316 CQNGGTCVPGADAHSCDCGPGFKGRRCELACIK--VSRPCTRLFSETKAFPVWEGGVCHH 1373

Query: 641  I 641
            +
Sbjct: 1374 V 1374



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 27/71 (38%), Positives = 33/71 (46%), Gaps = 7/71 (9%)

Query: 271  GRFGKNCSQECQCHNGGTC--DAATGQCHCSPGYTGERCQDECPVGTYGV--LCAET--C 324
            G    NCS+   C NGGTC   A    C C PG+ G RC+  C   +     L +ET   
Sbjct: 1305 GNVPGNCSEN-PCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAF 1363

Query: 325  QCVNGGKCYHV 335
                GG C+HV
Sbjct: 1364 PVWEGGVCHHV 1374



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 28/75 (37%), Positives = 32/75 (42%), Gaps = 15/75 (20%)

Query: 185  GTYGNDCHQRCQCQNGATCDHVTG----ECRCPPGYTGAFCEDLCPPGKHGPQC------ 234
            G    +C +   CQNG TC  V G     C C PG+ G  CE  C   K    C      
Sbjct: 1305 GNVPGNCSEN-PCQNGGTC--VPGADAHSCDCGPGFKGRRCELACI--KVSRPCTRLFSE 1359

Query: 235  EQRCPCQNGGVCHHV 249
             +  P   GGVCHHV
Sbjct: 1360 TKAFPVWEGGVCHHV 1374



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 14/31 (45%), Positives = 18/31 (58%), Gaps = 2/31 (6%)

Query: 501  CLNGGAC--NTLDGTCTCAPGWRGEKCELPC 529
            C NGG C       +C C PG++G +CEL C
Sbjct: 1316 CQNGGTCVPGADAHSCDCGPGFKGRRCELAC 1346



 Score = 34.3 bits (77), Expect = 0.69
 Identities = 17/39 (43%), Positives = 19/39 (48%), Gaps = 2/39 (5%)

Query: 146  PHCTSRCQCKNGALCNPITGA--CHCAAGFRGWRCEDRC 182
            P   S   C+NG  C P   A  C C  GF+G RCE  C
Sbjct: 1308 PGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELAC 1346



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 16/35 (45%), Positives = 17/35 (48%), Gaps = 4/35 (11%)

Query: 409  CQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPC 443
            CQ   +C  GAD  S    C C PGFKG  C   C
Sbjct: 1316 CQNGGTCVPGADAHS----CDCGPGFKGRRCELAC 1346



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 24/80 (30%), Positives = 27/80 (33%), Gaps = 19/80 (23%)

Query: 668  NCAGICT---CTNNGTCNP--IDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGA 722
            N  G C+   C N GTC P     SC C PG+ G  C   C                   
Sbjct: 1306 NVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKV--------------SR 1351

Query: 723  FCSAYDGECKCTPGWTGLYC 742
             C+    E K  P W G  C
Sbjct: 1352 PCTRLFSETKAFPVWEGGVC 1371



 Score = 31.6 bits (70), Expect = 4.5
 Identities = 30/112 (26%), Positives = 43/112 (38%), Gaps = 25/112 (22%)

Query: 320  CAETCQCVNGGKCYHVSGA--CLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHS 377
            C+E   C NGG C   + A  C C  GF G RCE          + C       ++ +  
Sbjct: 1311 CSEN-PCQNGGTCVPGADAHSCDCGPGFKGRRCE----------LAC-------IKVSRP 1352

Query: 378  CHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCT 429
            C  +  E    P W G  C+      +     Q IC  ++   C+S + K T
Sbjct: 1353 CTRLFSETKAFPVWEGGVCHHVYKRVY--RVHQDICFKES---CESTSLKKT 1399



 Score = 31.6 bits (70), Expect = 4.5
 Identities = 15/33 (45%), Positives = 16/33 (48%), Gaps = 6/33 (18%)

Query: 761  CQNGADCDHISG----QCTCRTGFMGRHCEQKC 789
            CQNG  C  + G     C C  GF GR CE  C
Sbjct: 1316 CQNGGTC--VPGADAHSCDCGPGFKGRRCELAC 1346



 Score = 31.2 bits (69), Expect = 5.9
 Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 10/58 (17%)

Query: 82   HGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSAC 139
            HG K +      C     ++G  CVP  AD          ++C C PG+ G  C  AC
Sbjct: 1299 HGSKDIGNVPGNCSENPCQNGGTCVPG-ADA---------HSCDCGPGFKGRRCELAC 1346



 Score = 30.8 bits (68), Expect = 7.7
 Identities = 17/51 (33%), Positives = 24/51 (47%), Gaps = 6/51 (11%)

Query: 804  CLNNSTCDHITG----TCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALP 850
            C N  TC  + G    +C C PG+KG RC+ A + +      L   + A P
Sbjct: 1316 CQNGGTC--VPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFP 1364


>gi|145309306 scavenger receptor class F, member 1 isoform 5
           precursor [Homo sapiens]
          Length = 744

 Score =  205 bits (522), Expect = 2e-52
 Identities = 124/362 (34%), Positives = 152/362 (41%), Gaps = 62/362 (17%)

Query: 423 SVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDC 482
           S + +  C  G++  D     P+      C     C+ D VC    G C CK G+ G  C
Sbjct: 34  SPSAELQCCAGWRQKDQECTIPI------CEGPDACQKDEVCVK-PGLCRCKPGFFGAHC 86

Query: 483 SIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERC 542
           S RCP   WG  C  +C C   G C    G C C     G +CE PC  G +G     RC
Sbjct: 87  SSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHG-----RC 141

Query: 543 DCSHADGCHPTTGHCRCLPGW-------------SGVHCDS-----VCAEGRWGPNCSLP 584
           D        P TG C C PGW             +   C+      VC  G WG  CS  
Sbjct: 142 D--------PATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFR 193

Query: 585 CYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGL 644
           C C +G+ C  D G C C PG+ G  CQ+ C              +CV   G C   +G 
Sbjct: 194 CNC-HGSPCEQDSGRCACRPGWWGPECQQQC--------------ECVR--GRCSAASGE 236

Query: 645 CDCLPGFTGALCNEVCPSGRFGKNCAGIC-TCTNNGTCNPIDRSCQ-CYPGWIGSDCSQP 702
           C C PGF GA C   CP+G  G  CA  C  C +N  C+P   SC+ C PGW G+ C QP
Sbjct: 237 CTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQP 296

Query: 703 CPPAHWGPNCIHTC-NCHNGAFCSAYDGECKCTPGW--TGLYCTQRCP--LGFYGKDCAL 757
           C P  +G +C   C +C +G  C    G C+   G   T L      P  L F G  C  
Sbjct: 297 CLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCSGSRDTALIAGSLVPLLLLFLGLACCA 356

Query: 758 IC 759
            C
Sbjct: 357 CC 358



 Score =  205 bits (521), Expect = 2e-52
 Identities = 104/288 (36%), Positives = 134/288 (46%), Gaps = 42/288 (14%)

Query: 93  QCCPGFYESGEMC-VPHCA--DKCVHGR-CIAPNTCQCEPGWGGTNCSSACDGDHWGPHC 148
           QCC G+ +  + C +P C   D C     C+ P  C+C+PG+ G +CSS C G +WGP C
Sbjct: 40  QCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDC 99

Query: 149 TSRCQCKNGALCNPITGACHCAAGFRGWRCE-----------------DRCEQGTYGNDC 191
              C C     C P TGAC C A   G RCE                   CE G + + C
Sbjct: 100 RESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTC 159

Query: 192 HQRCQCQNGAT-CDHVTGECRCPPGYTGAFC----------------EDLCPPGKHGPQC 234
            + CQC   A  C+  TG C C PG+ G  C                   C PG  GP+C
Sbjct: 160 RRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPEC 219

Query: 235 EQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQEC-QCHNGGTCDAAT 293
           +Q+C C  G  C   +GEC+CP G+ G  C  PCP G  G  C+  C +C +   C   T
Sbjct: 220 QQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDT 278

Query: 294 GQCH-CSPGYTGERCQDECPVGTYGVLCAETC-QCVNGGKCYHVSGAC 339
           G C  C PG+ G +CQ  C  GT+G  C + C  C +G  C   +G C
Sbjct: 279 GSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHC 326



 Score =  197 bits (501), Expect = 5e-50
 Identities = 94/264 (35%), Positives = 121/264 (45%), Gaps = 38/264 (14%)

Query: 383 GECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTP 442
           G C CKPG+ G +C+  C   ++G  C++ C C     C+  TG C C     G  C  P
Sbjct: 73  GLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFP 132

Query: 443 CPLGTYG-----------------INCSSRCGCKNDAV-CSPVDGSCTCKAGWHGVDCSI 484
           C  G +G                   C   C C   A  C    G+C CK GW G  CS 
Sbjct: 133 CACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSF 192

Query: 485 R----------------CPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELP 528
           R                C  G WG  C   C+C+  G C+   G CTC PG+RG +CELP
Sbjct: 193 RCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVR-GRCSAASGECTCPPGFRGARCELP 251

Query: 529 CQDGTYGLNCAERCD-CSHADGCHPTTGHCR-CLPGWSGVHCDSVCAEGRWGPNCSLPC- 585
           C  G++G+ CA  C  C H + C P TG C  C PGW+G  C   C  G +G +C   C 
Sbjct: 252 CPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCP 311

Query: 586 YCKNGASCSPDDGICECAPGFRGT 609
           +C++G +C PD G C+   G R T
Sbjct: 312 HCRHGEACEPDTGHCQRCSGSRDT 335



 Score =  192 bits (488), Expect = 2e-48
 Identities = 105/309 (33%), Positives = 136/309 (44%), Gaps = 48/309 (15%)

Query: 250 TGECSCPSGWM--GTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERC 307
           + E  C +GW      C  P  EG           C     C    G C C PG+ G  C
Sbjct: 36  SAELQCCAGWRQKDQECTIPICEGPDA--------CQKDEVC-VKPGLCRCKPGFFGAHC 86

Query: 308 QDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARL------------- 354
              CP   +G  C E+C C   G+C   +GAC C+A   G RCE                
Sbjct: 87  SSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATG 146

Query: 355 ---CPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCS---------- 401
              C  G +   C + C C+      C   +G C CKPGW G  C+  C+          
Sbjct: 147 VCHCEPGWWSSTCRRPCQCNTAAAR-CEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDS 205

Query: 402 ------PGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSR 455
                 PG++G  CQQ C C  G  C + +G+CTC PGF+G  C  PCP G++G+ C+  
Sbjct: 206 GRCACRPGWWGPECQQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGVQCAHS 264

Query: 456 CG-CKNDAVCSPVDGSC-TCKAGWHGVDCSIRCPSGTWGFGCNLTC-QCLNGGACNTLDG 512
           CG CK++  CSP  GSC +C+ GW+G  C   C  GT+G  C   C  C +G AC    G
Sbjct: 265 CGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTG 324

Query: 513 TCTCAPGWR 521
            C    G R
Sbjct: 325 HCQRCSGSR 333



 Score =  165 bits (417), Expect = 3e-40
 Identities = 93/279 (33%), Positives = 118/279 (42%), Gaps = 46/279 (16%)

Query: 581 CSLPCYCKNGASCSPDD-----GICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSS 635
           C++P  C+   +C  D+     G+C C PGF G  C   C   ++G  C ++CP   H  
Sbjct: 52  CTIPI-CEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCP--CHPH 108

Query: 636 GPCHHITGLCDCLPGFTGALCNEVCPSGRFGK--NCAGICTC----------------TN 677
           G C   TG C C     GA C   C  G  G+     G+C C                T 
Sbjct: 109 GQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTA 168

Query: 678 NGTCNPIDRSCQCYPGWIGSDCS-------QPCP---------PAHWGPNCIHTCNCHNG 721
              C     +C C PGW G  CS        PC          P  WGP C   C C  G
Sbjct: 169 AARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRG 228

Query: 722 AFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALIC-QCQNGADCDHISGQC-TCRTG 779
             CSA  GEC C PG+ G  C   CP G +G  CA  C +C++   C   +G C +C  G
Sbjct: 229 R-CSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPG 287

Query: 780 FMGRHCEQKCPSGTYGYGCRQIC-DCLNNSTCDHITGTC 817
           + G  C+Q C  GT+G  C Q C  C +   C+  TG C
Sbjct: 288 WNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHC 326



 Score =  156 bits (395), Expect = 9e-38
 Identities = 79/224 (35%), Positives = 98/224 (43%), Gaps = 37/224 (16%)

Query: 643 GLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQP 702
           GLC C PGF GA C+  CP   +G +C   C C  +G C P   +CQC     G+ C  P
Sbjct: 73  GLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFP 132

Query: 703 -----------------CPPAHWGPNCIHTCNCHNGAF-CSAYDGECKCTPGWTGLYCTQ 744
                            C P  W   C   C C+  A  C    G C C PGW G  C+ 
Sbjct: 133 CACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSF 192

Query: 745 RCPL----------------GFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQK 788
           RC                  G++G +C   C+C  G  C   SG+CTC  GF G  CE  
Sbjct: 193 RCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGR-CSAASGECTCPPGFRGARCELP 251

Query: 789 CPSGTYGYGCRQICD-CLNNSTCDHITGTC-YCSPGWKGARCDQ 830
           CP+G++G  C   C  C +N  C   TG+C  C PGW G +C Q
Sbjct: 252 CPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQ 295



 Score =  129 bits (325), Expect = 1e-29
 Identities = 70/185 (37%), Positives = 88/185 (47%), Gaps = 23/185 (12%)

Query: 94  CCPGFYESGEMCVPHCADKCVHGRCI-APNTCQCEPGWGGTNCS-------SACDGDH-- 143
           C PG++ S   C   C       RC  A   C C+PGW G  CS       S C+ D   
Sbjct: 150 CEPGWWSS--TCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGR 207

Query: 144 -------WGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRC- 195
                  WGP C  +C+C  G  C+  +G C C  GFRG RCE  C  G++G  C   C 
Sbjct: 208 CACRPGWWGPECQQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCG 266

Query: 196 QCQNGATCDHVTGECR-CPPGYTGAFCEDLCPPGKHGPQCEQRCP-CQNGGVCHHVTGEC 253
           +C++   C   TG C  C PG+ G  C+  C PG  G  CEQ+CP C++G  C   TG C
Sbjct: 267 RCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHC 326

Query: 254 SCPSG 258
              SG
Sbjct: 327 QRCSG 331



 Score =  113 bits (283), Expect = 9e-25
 Identities = 59/195 (30%), Positives = 82/195 (42%), Gaps = 36/195 (18%)

Query: 669 CAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYD 728
           C G   C  +  C      C+C PG+ G+ CS  CP  +WGP+C  +C CH    C    
Sbjct: 57  CEGPDACQKDEVCVK-PGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPAT 115

Query: 729 GECKCTPGWTGLYCTQRCPLGFYGK-----------------DCALICQCQN-GADCDHI 770
           G C+C     G  C   C  G +G+                  C   CQC    A C+  
Sbjct: 116 GACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQA 175

Query: 771 SGQCTCRTGFMGRHCEQK----------------CPSGTYGYGCRQICDCLNNSTCDHIT 814
           +G C C+ G+ GR C  +                C  G +G  C+Q C+C+    C   +
Sbjct: 176 TGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECV-RGRCSAAS 234

Query: 815 GTCYCSPGWKGARCD 829
           G C C PG++GARC+
Sbjct: 235 GECTCPPGFRGARCE 249



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 52/159 (32%), Positives = 66/159 (41%), Gaps = 27/159 (16%)

Query: 689 QCYPGWIGSDCSQPCP-PAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCP 747
           QC  GW   D  Q C  P   GP+      C     C    G C+C PG+ G +C+ RCP
Sbjct: 40  QCCAGWRQKD--QECTIPICEGPDA-----CQKDEVC-VKPGLCRCKPGFFGAHCSSRCP 91

Query: 748 LGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYG------------ 795
             ++G DC   C C     C+  +G C C+    G  CE  C  G +G            
Sbjct: 92  GQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCE 151

Query: 796 -----YGCRQICDCLNNST-CDHITGTCYCSPGWKGARC 828
                  CR+ C C   +  C+  TG C C PGW G RC
Sbjct: 152 PGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRC 190



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 29/77 (37%), Positives = 38/77 (49%), Gaps = 5/77 (6%)

Query: 102 GEMCVPHCADKCVHGRCIAPNT--CQ-CEPGWGGTNCSSACDGDHWGPHCTSRC-QCKNG 157
           G  C   C  +C H    +P+T  C+ CEPGW GT C   C    +G  C  +C  C++G
Sbjct: 258 GVQCAHSCG-RCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHG 316

Query: 158 ALCNPITGACHCAAGFR 174
             C P TG C   +G R
Sbjct: 317 EACEPDTGHCQRCSGSR 333


>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
            sapiens]
          Length = 3118

 Score =  182 bits (463), Expect = 1e-45
 Identities = 152/495 (30%), Positives = 203/495 (41%), Gaps = 98/495 (19%)

Query: 120  APNTCQCEPGWGGTNCSSA------CDGDHWGPHCTSRCQCKNGA-LCNPITGACHCAAG 172
            A   CQC PG+ G++C S        +G  +G  C   CQC   A  C+ +TG C     
Sbjct: 720  AVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGIC-EPCQCFGHAESCDDVTGECLNCKD 778

Query: 173  FRGWRCEDRCEQGTYG-------NDCHQRCQCQNGATCDHVTGECR-----------CPP 214
              G    D+C  G YG        DC Q C C      ++ +  C            CP 
Sbjct: 779  HTGGPYCDKCLPGFYGEPTKGTSEDC-QPCACPLNIPSNNFSPTCHLDRSLGLICDGCPV 837

Query: 215  GYTGAFCEDLC-----PPGKHGPQCEQRCPCQNG------GVCHHVTGEC-SCPSGWMGT 262
            GYTG  CE         P   G  C Q C C +       G C  ++G C  C  G  G 
Sbjct: 838  GYTGPRCERCAEGYFGQPSVPGGSC-QPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGR 896

Query: 263  VCGQPCPEGRFG-----KNCSQECQCHNGGT----CDAATGQCHCSPGYTGERCQDECPV 313
             C + C +G FG     KNC Q C+C+ GG+    C + TGQC C     G+RC D+C  
Sbjct: 897  YC-ELCADGYFGDAVDAKNC-QPCRCNAGGSFSEVCHSQTGQCECRANVQGQRC-DKCKA 953

Query: 314  GTYGVLCAETCQCVN----GGKCY--HVSGACLCEAGFAGERCEARLCPEGLYGIK---C 364
            GT+G+  A  C   N    G K +    SG C C+ G  G++C+   C  G +  +   C
Sbjct: 954  GTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDR--CAHGYFNFQEGGC 1011

Query: 365  DKRCPC-HLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQ---QICSCQN--- 417
               C C HL N  +C P +G C C P   G  C++ C+P  +G +     + C+C     
Sbjct: 1012 -TACECSHLGN--NCDPKTGRCICPPNTIGEKCSK-CAPNTWGHSITTGCKACNCSTVGS 1067

Query: 418  -GADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGC---KNDAV---------- 463
                C+  TG+C C P F G  C T C  G +     + C C     DA           
Sbjct: 1068 LDFQCNVNTGQCNCHPKFSGAKC-TECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCS 1126

Query: 464  CSPVDGSCTCKAGWHGVDCSIRCPSGTWG------FGCNLTCQCLNGGA-CNTLDGTCTC 516
            CS   G CTCK    G+ C  RC  G +G       GC+ +C C      C+   G    
Sbjct: 1127 CSDQTGQCTCKVNVEGIHCD-RCRPGKFGLDAKNPLGCS-SCYCFGTTTQCSEAKGLIRT 1184

Query: 517  APGWRGEKCELPCQD 531
                + E+  LP  D
Sbjct: 1185 WVTLKAEQTILPLVD 1199



 Score =  181 bits (460), Expect = 3e-45
 Identities = 148/498 (29%), Positives = 205/498 (41%), Gaps = 105/498 (21%)

Query: 167  CHCAAGFRGWRCED-----RCEQGTYGNDCHQRCQCQNGA-TCDHVTGEC-RCPPGYTGA 219
            C C  G+ G  CE      R   GT      + CQC   A +CD VTGEC  C     G 
Sbjct: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGP 783

Query: 220  FCEDLCPPGKHGPQCE------QRCPCQNGGVCHHVTGEC-----------SCPSGWMGT 262
            +C D C PG +G   +      Q C C      ++ +  C            CP G+ G 
Sbjct: 784  YC-DKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGP 842

Query: 263  VCGQPCPEGRFGK-----NCSQECQCHNG------GTCDAATGQC-HCSPGYTGERCQDE 310
             C + C EG FG+        Q CQC++       G+CD+ +G C  C PG TG  C + 
Sbjct: 843  RC-ERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYC-EL 900

Query: 311  CPVGTYG----VLCAETCQCVNGGK----CYHVSGACLCEAGFAGERCEARLCPEGLYGI 362
            C  G +G        + C+C  GG     C+  +G C C A   G+RC+   C  G +G+
Sbjct: 901  CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK--CKAGTFGL 958

Query: 363  KCDKRC-PCHLEN----THSCHPMSGECACKPGWSGLYCNETCSPGFYG--EACQQICSC 415
            +  + C PC+  +    +  C   SG+C C+PG +G  C + C+ G++   E     C C
Sbjct: 959  QSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKC-DRCAHGYFNFQEGGCTACEC 1016

Query: 416  QN-GADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKN-------DAVCSPV 467
             + G +CD  TG+C C P   G  CS  C   T+G + ++ C   N       D  C+  
Sbjct: 1017 SHLGNNCDPKTGRCICPPNTIGEKCS-KCAPNTWGHSITTGCKACNCSTVGSLDFQCNVN 1075

Query: 468  DGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCEL 527
             G C C   + G  C+  C  G W           N   CN  D             C L
Sbjct: 1076 TGQCNCHPKFSGAKCT-ECSRGHW-----------NYPRCNLCD-------------CFL 1110

Query: 528  PCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLP--- 584
            P  D T   +  ++C CS        TG C C     G+HCD  C  G++G +   P   
Sbjct: 1111 PGTDATTCDSETKKCSCS------DQTGQCTCKVNVEGIHCDR-CRPGKFGLDAKNPLGC 1163

Query: 585  --CYC-KNGASCSPDDGI 599
              CYC      CS   G+
Sbjct: 1164 SSCYCFGTTTQCSEAKGL 1181



 Score =  167 bits (424), Expect = 4e-41
 Identities = 151/502 (30%), Positives = 197/502 (39%), Gaps = 115/502 (22%)

Query: 385  CACKPGWSGLYCNETCSPG-------FYGEACQQICSCQNGAD-CDSVTGKCT------- 429
            C C PG++G  C E+C P         +G  C+  C C   A+ CD VTG+C        
Sbjct: 724  CQCPPGYTGSSC-ESCWPRHRRVNGTIFGGICEP-CQCFGHAESCDDVTGECLNCKDHTG 781

Query: 430  ------CAPGFKGI-------DCST-PCPLGTYGINCSSRCGCKNDA--VCSPVDGSCTC 473
                  C PGF G        DC    CPL     N S  C        +C   DG   C
Sbjct: 782  GPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLIC---DG---C 835

Query: 474  KAGWHGVDCSIRCPSGTWGF-----GCNLTCQCLNG------GACNTLDGTCT-CAPGWR 521
              G+ G  C  RC  G +G      G    CQC +       G+C++L G+C  C PG  
Sbjct: 836  PVGYTGPRCE-RCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTT 894

Query: 522  GEKCELPCQDGTYG-----LNCAERCDC----SHADGCHPTTGHCRCLPGWSGVHCDSVC 572
            G  CEL C DG +G      NC + C C    S ++ CH  TG C C     G  CD  C
Sbjct: 895  GRYCEL-CADGYFGDAVDAKNC-QPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK-C 951

Query: 573  AEGRWGPNCS---LPCYCKNGASCSPD---DGICECAPGFRGTTCQRICSPGFYG-HRCS 625
              G +G   +   +PC C +  S S D    G C C PG  G  C R C+ G++      
Sbjct: 952  KAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDR-CAHGYFNFQEGG 1010

Query: 626  QTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPS--GRFGKNCAGICTCTNNGT--- 680
             T  +C H    C   TG C C P   G  C++  P+  G         C C+  G+   
Sbjct: 1011 CTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDF 1070

Query: 681  -CNPIDRSCQCYPGWIGSDCSQPCPPAHWG-PNCIHTCNCHNGAFCSAYDGECKCTPGWT 738
             CN     C C+P + G+ C++ C   HW  P C + C+C                PG  
Sbjct: 1071 QCNVNTGQCNCHPKFSGAKCTE-CSRGHWNYPRC-NLCDCF--------------LPGTD 1114

Query: 739  GLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGC 798
               C          K C+  C  Q G        QCTC+    G HC+ +C  G +G   
Sbjct: 1115 ATTCDSET------KKCS--CSDQTG--------QCTCKVNVEGIHCD-RCRPGKFGLDA 1157

Query: 799  RQICDCLNNSTCDHITGTCYCS 820
            +    C   S+C     T  CS
Sbjct: 1158 KNPLGC---SSCYCFGTTTQCS 1176



 Score =  166 bits (420), Expect = 1e-40
 Identities = 153/484 (31%), Positives = 201/484 (41%), Gaps = 106/484 (21%)

Query: 287  GTCDAATGQCHCSPGYTGERCQDECP-----VGT-YGVLCAETCQCV-NGGKCYHVSGAC 339
            G+  AA   C C PGYTG  C+   P      GT +G +C E CQC  +   C  V+G C
Sbjct: 715  GSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGIC-EPCQCFGHAESCDDVTGEC 773

Query: 340  L-CEAGFAGERCEARLCPEGLYG-------IKCDK-RCPCHLENTH---SCH---PMSGE 384
            L C+    G  C+   C  G YG         C    CP ++ + +   +CH    +   
Sbjct: 774  LNCKDHTGGPYCDK--CLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLI 831

Query: 385  C-ACKPGWSGLYCNETCSPGFYGE------ACQQICSCQNGAD------CDSVTGKC-TC 430
            C  C  G++G  C E C+ G++G+      +CQ  C C +  D      CDS++G C  C
Sbjct: 832  CDGCPVGYTGPRC-ERCAEGYFGQPSVPGGSCQP-CQCNDNLDFSIPGSCDSLSGSCLIC 889

Query: 431  APGFKGIDCSTPCPLGTYG-----INCS-SRC--GCKNDAVCSPVDGSCTCKAGWHGVDC 482
             PG  G  C   C  G +G      NC   RC  G     VC    G C C+A   G  C
Sbjct: 890  KPGTTGRYCEL-CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRC 948

Query: 483  SIRCPSGTWGF----GCNLTCQCLNGGA----CNTLDGTCTCAPGWRGEKCELPCQDGTY 534
              +C +GT+G     GC + C C + G+    C    G C C PG  G+KC+  C  G +
Sbjct: 949  D-KCKAGTFGLQSARGC-VPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCD-RCAHGYF 1004

Query: 535  GL--NCAERCDCSH-ADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGA 591
                     C+CSH  + C P TG C C P   G  C S CA   WG + +  C   N +
Sbjct: 1005 NFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKC-SKCAPNTWGHSITTGCKACNCS 1063

Query: 592  S-------CSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGL 644
            +       C+ + G C C P F G  C   CS G + +      P+C            L
Sbjct: 1064 TVGSLDFQCNVNTGQCNCHPKFSGAKCTE-CSRGHWNY------PRC-----------NL 1105

Query: 645  CDC-LPGFTGALCNEVCPSGRFGKNCA-----GICTCTNNGTCNPIDRSCQCYPGWIGSD 698
            CDC LPG     C+         K C+     G CTC  N      DR   C PG  G D
Sbjct: 1106 CDCFLPGTDATTCDSET------KKCSCSDQTGQCTCKVNVEGIHCDR---CRPGKFGLD 1156

Query: 699  CSQP 702
               P
Sbjct: 1157 AKNP 1160



 Score =  139 bits (350), Expect = 2e-32
 Identities = 115/379 (30%), Positives = 156/379 (41%), Gaps = 72/379 (18%)

Query: 514  CTCAPGWRGEKCELPCQ------DGTYGLNCAERCDC-SHADGCHPTTGHC-RCLPGWSG 565
            C C PG+ G  CE  C       +GT      E C C  HA+ C   TG C  C     G
Sbjct: 724  CQCPPGYTGSSCE-SCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGG 782

Query: 566  VHCDSVCAEGRWGP-------NCSLPCYC-------KNGASCSPDDG---ICE-CAPGFR 607
             +CD  C  G +G        +C  PC C           +C  D     IC+ C  G+ 
Sbjct: 783  PYCDK-CLPGFYGEPTKGTSEDCQ-PCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYT 840

Query: 608  GTTCQRICSPGFYGHRC--SQTCPQCVHSSGPCHHITGLCD--------CLPGFTGALCN 657
            G  C+R C+ G++G       +C  C  +      I G CD        C PG TG  C 
Sbjct: 841  GPRCER-CAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYC- 898

Query: 658  EVCPSGRFG-----KNCAGICTCTNNGT----CNPIDRSCQCYPGWIGSDCSQPCPPAHW 708
            E+C  G FG     KNC   C C   G+    C+     C+C     G  C + C    +
Sbjct: 899  ELCADGYFGDAVDAKNCQP-CRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK-CKAGTF 956

Query: 709  G----PNCIHTCNCHN---GAFCSAYDGECKCTPGWTGLYCTQRCPLGFYG--KDCALIC 759
            G      C+  CNC++    +F     G+C C PG TG  C  RC  G++   +     C
Sbjct: 957  GLQSARGCV-PCNCNSFGSKSFDCEESGQCWCQPGVTGKKC-DRCAHGYFNFQEGGCTAC 1014

Query: 760  QCQN-GADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNST-------CD 811
            +C + G +CD  +G+C C    +G  C  KC   T+G+     C   N ST       C+
Sbjct: 1015 ECSHLGNNCDPKTGRCICPPNTIGEKCS-KCAPNTWGHSITTGCKACNCSTVGSLDFQCN 1073

Query: 812  HITGTCYCSPGWKGARCDQ 830
              TG C C P + GA+C +
Sbjct: 1074 VNTGQCNCHPKFSGAKCTE 1092



 Score =  135 bits (340), Expect = 2e-31
 Identities = 136/520 (26%), Positives = 182/520 (35%), Gaps = 151/520 (29%)

Query: 42   VTVQESYPHPFDQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYES 101
            V +Q +Y    D I+  S  ++          VSY T    G         QC PG+  S
Sbjct: 684  VLLQITYSFGMDAIFRLSSVNL-------ESAVSYPT---DGSIAAAVEVCQCPPGYTGS 733

Query: 102  -----------------GEMCVP-HC---ADKC--VHGRCIAPNTCQCEPGWGGTNCSSA 138
                             G +C P  C   A+ C  V G C+      C+   GG  C   
Sbjct: 734  SCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECL-----NCKDHTGGPYCDKC 788

Query: 139  CDGDHWGP-----HCTSRCQCKNGALCNPITGACH-----------CAAGFRGWRCEDRC 182
              G +  P          C C      N  +  CH           C  G+ G RCE RC
Sbjct: 789  LPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCE-RC 847

Query: 183  EQGTYGN------DCHQRCQCQNG------ATCDHVTGECR-CPPGYTGAFCEDLCPPGK 229
             +G +G        C Q CQC +        +CD ++G C  C PG TG +CE LC  G 
Sbjct: 848  AEGYFGQPSVPGGSC-QPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCE-LCADGY 905

Query: 230  HGPQCE----QRCPCQNGG----VCHHVTGECSCPSGWMGTVCGQP-------------- 267
             G   +    Q C C  GG    VCH  TG+C C +   G  C +               
Sbjct: 906  FGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCV 965

Query: 268  ---------------------CPEGRFGKNCSQ--------------ECQC-HNGGTCDA 291
                                 C  G  GK C +               C+C H G  CD 
Sbjct: 966  PCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDP 1025

Query: 292  ATGQCHCSPGYTGERCQDECPVGTYG---VLCAETCQCVNGG----KCYHVSGACLCEAG 344
             TG+C C P   GE+C  +C   T+G       + C C   G    +C   +G C C   
Sbjct: 1026 KTGRCICPPNTIGEKC-SKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPK 1084

Query: 345  FAGERCEARLCPEGLYGIKCDKRCPCHLENTH-----------SCHPMSGECACKPGWSG 393
            F+G +C    C  G +       C C L  T            SC   +G+C CK    G
Sbjct: 1085 FSGAKCTE--CSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEG 1142

Query: 394  LYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPG 433
            ++C + C PG +G   +    C +   C   T +C+ A G
Sbjct: 1143 IHC-DRCRPGKFGLDAKNPLGC-SSCYCFGTTTQCSEAKG 1180



 Score =  128 bits (321), Expect = 4e-29
 Identities = 127/469 (27%), Positives = 175/469 (37%), Gaps = 97/469 (20%)

Query: 447  TYGINCSSRCGCKN--DAVCSPVDGS-------CTCKAGWHGVDCSIRCP-----SGTWG 492
            ++G++   R    N   AV  P DGS       C C  G+ G  C    P     +GT  
Sbjct: 691  SFGMDAIFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIF 750

Query: 493  FGCNLTCQCL-NGGACNTLDGTC-TCAPGWRGEKCELPCQDGTYG------LNCAERCDC 544
             G    CQC  +  +C+ + G C  C     G  C+  C  G YG          + C C
Sbjct: 751  GGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCD-KCLPGFYGEPTKGTSEDCQPCAC 809

Query: 545  S---HADGCHPTTGHCR--------CLPGWSGVHCDSVCAEGRWGP------NCSLPCYC 587
                 ++   PT    R        C  G++G  C+  CAEG +G       +C  PC C
Sbjct: 810  PLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCER-CAEGYFGQPSVPGGSCQ-PCQC 867

Query: 588  KNG------ASCSPDDGICE-CAPGFRGTTCQRICSPGFYGHRC-SQTCPQCVHSSGP-- 637
             +        SC    G C  C PG  G  C+ +C+ G++G    ++ C  C  ++G   
Sbjct: 868  NDNLDFSIPGSCDSLSGSCLICKPGTTGRYCE-LCADGYFGDAVDAKNCQPCRCNAGGSF 926

Query: 638  ---CHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRS------- 687
               CH  TG C+C     G  C++ C +G FG   A  C   N   CN            
Sbjct: 927  SEVCHSQTGQCECRANVQGQRCDK-CKAGTFGLQSARGCVPCN---CNSFGSKSFDCEES 982

Query: 688  --CQCYPGWIGSDCSQPCPPAHWG---PNCIHTCNC-HNGAFCSAYDGECKCTPGWTGLY 741
              C C PG  G  C + C   ++      C   C C H G  C    G C C P   G  
Sbjct: 983  GQCWCQPGVTGKKCDR-CAHGYFNFQEGGCT-ACECSHLGNNCDPKTGRCICPPNTIGEK 1040

Query: 742  CTQRCPLGFYGKDCALICQCQNGA-------DCDHISGQCTCRTGFMGRHCEQKCPSGTY 794
            C+ +C    +G      C+  N +        C+  +GQC C   F G  C + C  G +
Sbjct: 1041 CS-KCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTE-CSRGHW 1098

Query: 795  GYGCRQICDCLNNST-------------CDHITGTCYCSPGWKGARCDQ 830
             Y    +CDC    T             C   TG C C    +G  CD+
Sbjct: 1099 NYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDR 1147



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 70/242 (28%), Positives = 92/242 (38%), Gaps = 74/242 (30%)

Query: 209  ECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPC 268
            +C CP GY+G  CE  C PG +      R   Q GG           P   +GT      
Sbjct: 1379 KCDCPLGYSGLSCE-ACLPGFY------RLRSQPGG---------RTPGPTLGTCV---- 1418

Query: 269  PEGRFGKNCSQECQCH-NGGTCDAATGQC-HCSPGYTGERCQDECPVGTYGVLCA----- 321
                        CQC+ +   CD  T  C +C     G+ C+  C +G YG++       
Sbjct: 1419 -----------PCQCNGHSSLCDPETSICQNCQHHTAGDFCE-RCALGYYGIVKGLPNDC 1466

Query: 322  ETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPM 381
            + C C       + S +C+ E G    RC A  CP G  G  C++               
Sbjct: 1467 QQCACPLISSSNNFSPSCVAE-GLDDYRCTA--CPRGYEGQYCER--------------- 1508

Query: 382  SGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGAD----CDSVTGKCTCAPGFKGI 437
                 C PG++G       SPG  G +CQ+ C C         CD VTG CTC PG  G 
Sbjct: 1509 -----CAPGYTG-------SPGNPGGSCQE-CECDPYGSLPVPCDPVTGFCTCRPGATGR 1555

Query: 438  DC 439
             C
Sbjct: 1556 KC 1557



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 68/230 (29%), Positives = 91/230 (39%), Gaps = 60/230 (26%)

Query: 124  CQCEPGWGGTNCSSACDGDHW----------GPHCTS--RCQCK-NGALCNPITGAC-HC 169
            C C  G+ G +C +   G +           GP   +   CQC  + +LC+P T  C +C
Sbjct: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNC 1439

Query: 170  AAGFRGWRCEDRCEQGTYG------NDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCED 223
                 G  CE RC  G YG      NDC Q+C C   ++ ++ +  C    G     C  
Sbjct: 1440 QHHTAGDFCE-RCALGYYGIVKGLPNDC-QQCACPLISSSNNFSPSC-VAEGLDDYRCT- 1495

Query: 224  LCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQC 283
             CP G  G  CE+                  C  G+ G+        G  G +C QEC+C
Sbjct: 1496 ACPRGYEGQYCER------------------CAPGYTGS-------PGNPGGSC-QECEC 1529

Query: 284  HNGGT----CDAATGQCHCSPGYTGERCQDECP-----VGTYGVLCAETC 324
               G+    CD  TG C C PG TG +C D C       G   V C + C
Sbjct: 1530 DPYGSLPVPCDPVTGFCTCRPGATGRKC-DGCKHWHAREGWECVFCGDEC 1578



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 63/228 (27%), Positives = 74/228 (32%), Gaps = 67/228 (29%)

Query: 384  ECACKPGWSGLYCNETCSPGFYGEACQQ-------------ICSCQNGAD-CDSVTGKCT 429
            +C C  G+SGL C E C PGFY    Q               C C   +  CD  T  C 
Sbjct: 1379 KCDCPLGYSGLSC-EACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQ 1437

Query: 430  CAPGFKGIDCSTPCPLGTYGI-----NCSSRCGCKNDAVCSPVDGSCT-----------C 473
                    D    C LG YGI     N   +C C   +  +    SC            C
Sbjct: 1438 NCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497

Query: 474  KAGWHGVDCSIRCPSGTWGF-----GCNLTCQCLNGGA----CNTLDGTCTCAPGWRGEK 524
              G+ G  C  RC  G  G      G    C+C   G+    C+ + G CTC PG  G K
Sbjct: 1498 PRGYEGQYCE-RCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556

Query: 525  CELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVC 572
            C                      DGC     H     GW  V C   C
Sbjct: 1557 C----------------------DGCK----HWHAREGWECVFCGDEC 1578



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 61/213 (28%), Positives = 80/213 (37%), Gaps = 62/213 (29%)

Query: 645  CDCLPGFTGALCNEVCPSG--RFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQP 702
            CDC  G++G  C E C  G  R      G       GTC P    CQC      +  S  
Sbjct: 1380 CDCPLGYSGLSC-EACLPGFYRLRSQPGGRTPGPTLGTCVP----CQC------NGHSSL 1428

Query: 703  CPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYG------KDCA 756
            C P         T  C N            C     G +C +RC LG+YG       DC 
Sbjct: 1429 CDP--------ETSICQN------------CQHHTAGDFC-ERCALGYYGIVKGLPNDCQ 1467

Query: 757  LICQCQNGADCDHISGQCT-----------CRTGFMGRHCEQKCPS-----GTYGYGCRQ 800
              C C   +  ++ S  C            C  G+ G++CE+  P      G  G  C++
Sbjct: 1468 Q-CACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQE 1526

Query: 801  ICDCLNNST----CDHITGTCYCSPGWKGARCD 829
             C+C    +    CD +TG C C PG  G +CD
Sbjct: 1527 -CECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 56/219 (25%), Positives = 74/219 (33%), Gaps = 63/219 (28%)

Query: 671 GICTCTNNGTCNPIDRS-----CQCYPGWIGSDCSQPCPPAHWGP----------NCIHT 715
           G+C C  +    P+D +     C+C     G  C Q CP  H  P           C   
Sbjct: 285 GMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTEC-EA 343

Query: 716 CNCHNGAFCSAYD-------------------GEC-KCTPGWTGLYCTQRCPLGF----- 750
           CNCH  A    YD                   G C  CT    G+ C + C  GF     
Sbjct: 344 CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINC-ETCTDGFFRPKG 402

Query: 751 ----YGKDCALICQCQNGADCDHI-------------SGQCTCRTGFMGRHCEQKCPSGT 793
               Y + C   C C      + +              G C C+TGF G  C+ +C  G 
Sbjct: 403 VSPNYPRPCQ-PCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCD-RCARGY 460

Query: 794 YGYGCRQICDC--LNNSTCDHITGTCYCSPGWKGARCDQ 830
            GY   + C+C  L +   D   G C C    +G  C +
Sbjct: 461 TGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSR 499



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 55/182 (30%), Positives = 73/182 (40%), Gaps = 41/182 (22%)

Query: 514  CTCAPGWRGEKCELPCQDGTYGLNCAER-------------CDCS-HADGCHPTTGHCR- 558
            C C  G+ G  CE  C  G Y L                  C C+ H+  C P T  C+ 
Sbjct: 1380 CDCPLGYSGLSCEA-CLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438

Query: 559  CLPGWSGVHCDSVCAEGRWG-----PNCSLPCYC---KNGASCSP-------DDGICECA 603
            C    +G  C+  CA G +G     PN    C C    +  + SP       DD  C   
Sbjct: 1439 CQHHTAGDFCER-CALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497

Query: 604  P-GFRGTTCQRICSPGFYGHRCSQ--TCPQCVHSSG-----PCHHITGLCDCLPGFTGAL 655
            P G+ G  C+R C+PG+ G   +   +C +C          PC  +TG C C PG TG  
Sbjct: 1498 PRGYEGQYCER-CAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556

Query: 656  CN 657
            C+
Sbjct: 1557 CD 1558



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 69/270 (25%), Positives = 94/270 (34%), Gaps = 53/270 (19%)

Query: 332 CYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCP----------CHLENTH----S 377
           CY  + AC  +      RCE   C     G  CD+ CP            L  T     +
Sbjct: 289 CYGHARACPLDPATNKSRCE---CEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACN 345

Query: 378 CHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQN--GADCDSVTGKCTCAPGF- 434
           CH  + EC      +    +      + G      C+ QN  G +C+      TC  GF 
Sbjct: 346 CHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCT-QNTAGINCE------TCTDGFF 398

Query: 435 --KGIDCS-----TPC---PLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSI 484
             KG+  +      PC   P+G+    C      +  A      GSC CK G+ GV C  
Sbjct: 399 RPKGVSPNYPRPCQPCHCDPIGSLNEVCVKD---EKHARRGLAPGSCHCKTGFGGVSCD- 454

Query: 485 RCPSGTWGFGCNLTCQCLNGGACN--TLDGTCTCAPGWRGEKCELPCQDGTYGL-----N 537
           RC  G  G+     C C   G+ N     G C C     G  C   C+ G + L      
Sbjct: 455 RCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCS-RCKSGFFNLQEDNWK 513

Query: 538 CAERCDCS----HADGCHPTTGHCRCLPGW 563
             + C CS         + T G  + + GW
Sbjct: 514 GCDECFCSGVSNRCQSSYWTYGKIQDMSGW 543



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 73/301 (24%), Positives = 100/301 (33%), Gaps = 60/301 (19%)

Query: 450 INCSSRCGCKNDAVCSPVDGS-----CTCKAGWHGVDCSIRCPS---GTWGFGCNLT-CQ 500
           I+    C C   A   P+D +     C C+    G  C   CP      W  G  LT  +
Sbjct: 281 ISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTE 340

Query: 501 CLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHC-RC 559
           C    ACN                C    ++  Y  N A R    +  G +   G C  C
Sbjct: 341 C---EACN----------------CHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINC 381

Query: 560 LPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGF 619
               +G++C++ C +G + P    P Y +    C P    C C P             G 
Sbjct: 382 TQNTAGINCET-CTDGFFRPKGVSPNYPR---PCQP----CHCDP------------IGS 421

Query: 620 YGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNG 679
               C +          P     G C C  GF G  C+  C  G  G      C C+  G
Sbjct: 422 LNEVCVKDEKHARRGLAP-----GSCHCKTGFGGVSCDR-CARGYTGYPDCKACNCSGLG 475

Query: 680 TCN--PIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGW 737
           + N  P    C C     G DCS+ C    +     +   C +  FCS     C+ +  W
Sbjct: 476 SKNEDPCFGPCICKENVEGGDCSR-CKSGFFNLQEDNWKGC-DECFCSGVSNRCQ-SSYW 532

Query: 738 T 738
           T
Sbjct: 533 T 533



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 65/232 (28%), Positives = 78/232 (33%), Gaps = 57/232 (24%)

Query: 413 CSCQN---GADCDSVTGKCTCAPGFKGIDCSTPCPLGTY-------GINCSSRCG-CKND 461
           C C++   G  CD       C PGF       P   GT+         NC  +   C  D
Sbjct: 307 CECEHNTCGDSCDQ------CCPGFH----QKPWRAGTFLTKTECEACNCHGKAEECYYD 356

Query: 462 AVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWR 521
              +  + S   +  + G    I C   T G  C                   TC  G+ 
Sbjct: 357 ENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCE------------------TCTDGFF 398

Query: 522 GEK-----CELPCQ----DGTYGLNCAERCDCSHAD-GCHPTTGHCRCLPGWSGVHCDSV 571
             K        PCQ    D    LN     D  HA  G  P  G C C  G+ GV CD  
Sbjct: 399 RPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAP--GSCHCKTGFGGVSCDR- 455

Query: 572 CAEGRWG-PNCSLPCYCKNGASCSPDD--GICECAPGFRGTTCQRICSPGFY 620
           CA G  G P+C   C C    S + D   G C C     G  C R C  GF+
Sbjct: 456 CARGYTGYPDCK-ACNCSGLGSKNEDPCFGPCICKENVEGGDCSR-CKSGFF 505



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 47/182 (25%), Positives = 59/182 (32%), Gaps = 57/182 (31%)

Query: 93  QCCPGFYESG------------EMCVPH-CADKC--------------VHGRCIAPNTC- 124
           QCCPGF++              E C  H  A++C              + G+ I    C 
Sbjct: 320 QCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCI 379

Query: 125 QCEPGWGGTNCSSACDG----DHWGPHCTSRCQCKNGALCNPI----------------- 163
            C     G NC +  DG        P+    CQ      C+PI                 
Sbjct: 380 NCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQ---PCHCDPIGSLNEVCVKDEKHARRG 436

Query: 164 --TGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQ--NGATCDHVTGECRCPPGYTGA 219
              G+CHC  GF G  C DRC +G  G    + C C        D   G C C     G 
Sbjct: 437 LAPGSCHCKTGFGGVSC-DRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGG 495

Query: 220 FC 221
            C
Sbjct: 496 DC 497



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 17/120 (14%)

Query: 95  CPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQC 154
           C       E+CV    D+    R +AP +C C+ G+GG +C     G    P C + C C
Sbjct: 416 CDPIGSLNEVCVK---DEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKA-CNC 471

Query: 155 KNGALCN--PITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRC 212
                 N  P  G C C     G  C  RC+ G +        Q  N   CD    EC C
Sbjct: 472 SGLGSKNEDPCFGPCICKENVEGGDC-SRCKSGFF------NLQEDNWKGCD----ECFC 520



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 69/272 (25%), Positives = 83/272 (30%), Gaps = 76/272 (27%)

Query: 102 GEMCVPHC-ADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGP----------HCTS 150
           G MC+ +  A  C        + C+CE    G +C   C G H  P           C +
Sbjct: 284 GGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEA 343

Query: 151 RCQCKNGA-------------LCNPITG-------ACHCAAGFRGWRCEDRCEQG----- 185
            C C   A             L   I G         +C     G  CE  C  G     
Sbjct: 344 -CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCE-TCTDGFFRPK 401

Query: 186 ----TYGNDCHQRCQCQNGATCDHV-------------TGECRCPPGYTGAFCEDLCPPG 228
                Y   C Q C C    + + V              G C C  G+ G  C D C  G
Sbjct: 402 GVSPNYPRPC-QPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSC-DRCARG 459

Query: 229 KHG-PQCEQRCPCQNGGVCHH--VTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHN 285
             G P C + C C   G  +     G C C     G  C + C  G F        Q  N
Sbjct: 460 YTGYPDC-KACNCSGLGSKNEDPCFGPCICKENVEGGDCSR-CKSGFF------NLQEDN 511

Query: 286 GGTCDAATGQCHCSPGYTGERCQDECPVGTYG 317
              CD    +C CS      RCQ      TYG
Sbjct: 512 WKGCD----ECFCSG--VSNRCQSS--YWTYG 535



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 38/157 (24%), Positives = 61/157 (38%), Gaps = 35/157 (22%)

Query: 730  ECKCTPGWTGLYCTQRCPLGFY-------GK------DCALICQCQNGAD-CDHISGQC- 774
            +C C  G++GL C + C  GFY       G+         + CQC   +  CD  +  C 
Sbjct: 1379 KCDCPLGYSGLSC-EACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQ 1437

Query: 775  TCRTGFMGRHCEQKCPSGTYGY------GCRQICDCLNNSTCDHITGTCY---------- 818
             C+    G  CE +C  G YG        C+Q C C   S+ ++ + +C           
Sbjct: 1438 NCQHHTAGDFCE-RCALGYYGIVKGLPNDCQQ-CACPLISSSNNFSPSCVAEGLDDYRCT 1495

Query: 819  -CSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSY 854
             C  G++G  C++      G+  +   +      D Y
Sbjct: 1496 ACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPY 1532



 Score = 35.0 bits (79), Expect = 0.41
 Identities = 28/96 (29%), Positives = 36/96 (37%), Gaps = 14/96 (14%)

Query: 93   QCCPGFYESGEMCVPHC-ADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPH---- 147
            QC      S     P C A+     RC A     C  G+ G  C     G    P     
Sbjct: 1468 QCACPLISSSNNFSPSCVAEGLDDYRCTA-----CPRGYEGQYCERCAPGYTGSPGNPGG 1522

Query: 148  CTSRCQCKN-GAL---CNPITGACHCAAGFRGWRCE 179
                C+C   G+L   C+P+TG C C  G  G +C+
Sbjct: 1523 SCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558


>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
            sapiens]
          Length = 3122

 Score =  182 bits (463), Expect = 1e-45
 Identities = 152/495 (30%), Positives = 203/495 (41%), Gaps = 98/495 (19%)

Query: 120  APNTCQCEPGWGGTNCSSA------CDGDHWGPHCTSRCQCKNGA-LCNPITGACHCAAG 172
            A   CQC PG+ G++C S        +G  +G  C   CQC   A  C+ +TG C     
Sbjct: 720  AVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGIC-EPCQCFGHAESCDDVTGECLNCKD 778

Query: 173  FRGWRCEDRCEQGTYG-------NDCHQRCQCQNGATCDHVTGECR-----------CPP 214
              G    D+C  G YG        DC Q C C      ++ +  C            CP 
Sbjct: 779  HTGGPYCDKCLPGFYGEPTKGTSEDC-QPCACPLNIPSNNFSPTCHLDRSLGLICDGCPV 837

Query: 215  GYTGAFCEDLC-----PPGKHGPQCEQRCPCQNG------GVCHHVTGEC-SCPSGWMGT 262
            GYTG  CE         P   G  C Q C C +       G C  ++G C  C  G  G 
Sbjct: 838  GYTGPRCERCAEGYFGQPSVPGGSC-QPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGR 896

Query: 263  VCGQPCPEGRFG-----KNCSQECQCHNGGT----CDAATGQCHCSPGYTGERCQDECPV 313
             C + C +G FG     KNC Q C+C+ GG+    C + TGQC C     G+RC D+C  
Sbjct: 897  YC-ELCADGYFGDAVDAKNC-QPCRCNAGGSFSEVCHSQTGQCECRANVQGQRC-DKCKA 953

Query: 314  GTYGVLCAETCQCVN----GGKCY--HVSGACLCEAGFAGERCEARLCPEGLYGIK---C 364
            GT+G+  A  C   N    G K +    SG C C+ G  G++C+   C  G +  +   C
Sbjct: 954  GTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDR--CAHGYFNFQEGGC 1011

Query: 365  DKRCPC-HLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQ---QICSCQN--- 417
               C C HL N  +C P +G C C P   G  C++ C+P  +G +     + C+C     
Sbjct: 1012 -TACECSHLGN--NCDPKTGRCICPPNTIGEKCSK-CAPNTWGHSITTGCKACNCSTVGS 1067

Query: 418  -GADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGC---KNDAV---------- 463
                C+  TG+C C P F G  C T C  G +     + C C     DA           
Sbjct: 1068 LDFQCNVNTGQCNCHPKFSGAKC-TECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCS 1126

Query: 464  CSPVDGSCTCKAGWHGVDCSIRCPSGTWG------FGCNLTCQCLNGGA-CNTLDGTCTC 516
            CS   G CTCK    G+ C  RC  G +G       GC+ +C C      C+   G    
Sbjct: 1127 CSDQTGQCTCKVNVEGIHCD-RCRPGKFGLDAKNPLGCS-SCYCFGTTTQCSEAKGLIRT 1184

Query: 517  APGWRGEKCELPCQD 531
                + E+  LP  D
Sbjct: 1185 WVTLKAEQTILPLVD 1199



 Score =  181 bits (460), Expect = 3e-45
 Identities = 148/498 (29%), Positives = 205/498 (41%), Gaps = 105/498 (21%)

Query: 167  CHCAAGFRGWRCED-----RCEQGTYGNDCHQRCQCQNGA-TCDHVTGEC-RCPPGYTGA 219
            C C  G+ G  CE      R   GT      + CQC   A +CD VTGEC  C     G 
Sbjct: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGP 783

Query: 220  FCEDLCPPGKHGPQCE------QRCPCQNGGVCHHVTGEC-----------SCPSGWMGT 262
            +C D C PG +G   +      Q C C      ++ +  C            CP G+ G 
Sbjct: 784  YC-DKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGP 842

Query: 263  VCGQPCPEGRFGK-----NCSQECQCHNG------GTCDAATGQC-HCSPGYTGERCQDE 310
             C + C EG FG+        Q CQC++       G+CD+ +G C  C PG TG  C + 
Sbjct: 843  RC-ERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYC-EL 900

Query: 311  CPVGTYG----VLCAETCQCVNGGK----CYHVSGACLCEAGFAGERCEARLCPEGLYGI 362
            C  G +G        + C+C  GG     C+  +G C C A   G+RC+   C  G +G+
Sbjct: 901  CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK--CKAGTFGL 958

Query: 363  KCDKRC-PCHLEN----THSCHPMSGECACKPGWSGLYCNETCSPGFYG--EACQQICSC 415
            +  + C PC+  +    +  C   SG+C C+PG +G  C + C+ G++   E     C C
Sbjct: 959  QSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKC-DRCAHGYFNFQEGGCTACEC 1016

Query: 416  QN-GADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKN-------DAVCSPV 467
             + G +CD  TG+C C P   G  CS  C   T+G + ++ C   N       D  C+  
Sbjct: 1017 SHLGNNCDPKTGRCICPPNTIGEKCS-KCAPNTWGHSITTGCKACNCSTVGSLDFQCNVN 1075

Query: 468  DGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCEL 527
             G C C   + G  C+  C  G W           N   CN  D             C L
Sbjct: 1076 TGQCNCHPKFSGAKCT-ECSRGHW-----------NYPRCNLCD-------------CFL 1110

Query: 528  PCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLP--- 584
            P  D T   +  ++C CS        TG C C     G+HCD  C  G++G +   P   
Sbjct: 1111 PGTDATTCDSETKKCSCS------DQTGQCTCKVNVEGIHCDR-CRPGKFGLDAKNPLGC 1163

Query: 585  --CYC-KNGASCSPDDGI 599
              CYC      CS   G+
Sbjct: 1164 SSCYCFGTTTQCSEAKGL 1181



 Score =  167 bits (424), Expect = 4e-41
 Identities = 151/502 (30%), Positives = 197/502 (39%), Gaps = 115/502 (22%)

Query: 385  CACKPGWSGLYCNETCSPG-------FYGEACQQICSCQNGAD-CDSVTGKCT------- 429
            C C PG++G  C E+C P         +G  C+  C C   A+ CD VTG+C        
Sbjct: 724  CQCPPGYTGSSC-ESCWPRHRRVNGTIFGGICEP-CQCFGHAESCDDVTGECLNCKDHTG 781

Query: 430  ------CAPGFKGI-------DCST-PCPLGTYGINCSSRCGCKNDA--VCSPVDGSCTC 473
                  C PGF G        DC    CPL     N S  C        +C   DG   C
Sbjct: 782  GPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLIC---DG---C 835

Query: 474  KAGWHGVDCSIRCPSGTWGF-----GCNLTCQCLNG------GACNTLDGTCT-CAPGWR 521
              G+ G  C  RC  G +G      G    CQC +       G+C++L G+C  C PG  
Sbjct: 836  PVGYTGPRCE-RCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTT 894

Query: 522  GEKCELPCQDGTYG-----LNCAERCDC----SHADGCHPTTGHCRCLPGWSGVHCDSVC 572
            G  CEL C DG +G      NC + C C    S ++ CH  TG C C     G  CD  C
Sbjct: 895  GRYCEL-CADGYFGDAVDAKNC-QPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK-C 951

Query: 573  AEGRWGPNCS---LPCYCKNGASCSPD---DGICECAPGFRGTTCQRICSPGFYG-HRCS 625
              G +G   +   +PC C +  S S D    G C C PG  G  C R C+ G++      
Sbjct: 952  KAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDR-CAHGYFNFQEGG 1010

Query: 626  QTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPS--GRFGKNCAGICTCTNNGT--- 680
             T  +C H    C   TG C C P   G  C++  P+  G         C C+  G+   
Sbjct: 1011 CTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDF 1070

Query: 681  -CNPIDRSCQCYPGWIGSDCSQPCPPAHWG-PNCIHTCNCHNGAFCSAYDGECKCTPGWT 738
             CN     C C+P + G+ C++ C   HW  P C + C+C                PG  
Sbjct: 1071 QCNVNTGQCNCHPKFSGAKCTE-CSRGHWNYPRC-NLCDCF--------------LPGTD 1114

Query: 739  GLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGC 798
               C          K C+  C  Q G        QCTC+    G HC+ +C  G +G   
Sbjct: 1115 ATTCDSET------KKCS--CSDQTG--------QCTCKVNVEGIHCD-RCRPGKFGLDA 1157

Query: 799  RQICDCLNNSTCDHITGTCYCS 820
            +    C   S+C     T  CS
Sbjct: 1158 KNPLGC---SSCYCFGTTTQCS 1176



 Score =  166 bits (420), Expect = 1e-40
 Identities = 153/484 (31%), Positives = 201/484 (41%), Gaps = 106/484 (21%)

Query: 287  GTCDAATGQCHCSPGYTGERCQDECP-----VGT-YGVLCAETCQCV-NGGKCYHVSGAC 339
            G+  AA   C C PGYTG  C+   P      GT +G +C E CQC  +   C  V+G C
Sbjct: 715  GSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGIC-EPCQCFGHAESCDDVTGEC 773

Query: 340  L-CEAGFAGERCEARLCPEGLYG-------IKCDK-RCPCHLENTH---SCH---PMSGE 384
            L C+    G  C+   C  G YG         C    CP ++ + +   +CH    +   
Sbjct: 774  LNCKDHTGGPYCDK--CLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLI 831

Query: 385  C-ACKPGWSGLYCNETCSPGFYGE------ACQQICSCQNGAD------CDSVTGKC-TC 430
            C  C  G++G  C E C+ G++G+      +CQ  C C +  D      CDS++G C  C
Sbjct: 832  CDGCPVGYTGPRC-ERCAEGYFGQPSVPGGSCQP-CQCNDNLDFSIPGSCDSLSGSCLIC 889

Query: 431  APGFKGIDCSTPCPLGTYG-----INCS-SRC--GCKNDAVCSPVDGSCTCKAGWHGVDC 482
             PG  G  C   C  G +G      NC   RC  G     VC    G C C+A   G  C
Sbjct: 890  KPGTTGRYCEL-CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRC 948

Query: 483  SIRCPSGTWGF----GCNLTCQCLNGGA----CNTLDGTCTCAPGWRGEKCELPCQDGTY 534
              +C +GT+G     GC + C C + G+    C    G C C PG  G+KC+  C  G +
Sbjct: 949  D-KCKAGTFGLQSARGC-VPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCD-RCAHGYF 1004

Query: 535  GL--NCAERCDCSH-ADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGA 591
                     C+CSH  + C P TG C C P   G  C S CA   WG + +  C   N +
Sbjct: 1005 NFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKC-SKCAPNTWGHSITTGCKACNCS 1063

Query: 592  S-------CSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGL 644
            +       C+ + G C C P F G  C   CS G + +      P+C            L
Sbjct: 1064 TVGSLDFQCNVNTGQCNCHPKFSGAKCTE-CSRGHWNY------PRC-----------NL 1105

Query: 645  CDC-LPGFTGALCNEVCPSGRFGKNCA-----GICTCTNNGTCNPIDRSCQCYPGWIGSD 698
            CDC LPG     C+         K C+     G CTC  N      DR   C PG  G D
Sbjct: 1106 CDCFLPGTDATTCDSET------KKCSCSDQTGQCTCKVNVEGIHCDR---CRPGKFGLD 1156

Query: 699  CSQP 702
               P
Sbjct: 1157 AKNP 1160



 Score =  139 bits (350), Expect = 2e-32
 Identities = 115/379 (30%), Positives = 156/379 (41%), Gaps = 72/379 (18%)

Query: 514  CTCAPGWRGEKCELPCQ------DGTYGLNCAERCDC-SHADGCHPTTGHC-RCLPGWSG 565
            C C PG+ G  CE  C       +GT      E C C  HA+ C   TG C  C     G
Sbjct: 724  CQCPPGYTGSSCE-SCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGG 782

Query: 566  VHCDSVCAEGRWGP-------NCSLPCYC-------KNGASCSPDDG---ICE-CAPGFR 607
             +CD  C  G +G        +C  PC C           +C  D     IC+ C  G+ 
Sbjct: 783  PYCDK-CLPGFYGEPTKGTSEDCQ-PCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYT 840

Query: 608  GTTCQRICSPGFYGHRC--SQTCPQCVHSSGPCHHITGLCD--------CLPGFTGALCN 657
            G  C+R C+ G++G       +C  C  +      I G CD        C PG TG  C 
Sbjct: 841  GPRCER-CAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYC- 898

Query: 658  EVCPSGRFG-----KNCAGICTCTNNGT----CNPIDRSCQCYPGWIGSDCSQPCPPAHW 708
            E+C  G FG     KNC   C C   G+    C+     C+C     G  C + C    +
Sbjct: 899  ELCADGYFGDAVDAKNCQP-CRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK-CKAGTF 956

Query: 709  G----PNCIHTCNCHN---GAFCSAYDGECKCTPGWTGLYCTQRCPLGFYG--KDCALIC 759
            G      C+  CNC++    +F     G+C C PG TG  C  RC  G++   +     C
Sbjct: 957  GLQSARGCV-PCNCNSFGSKSFDCEESGQCWCQPGVTGKKC-DRCAHGYFNFQEGGCTAC 1014

Query: 760  QCQN-GADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNST-------CD 811
            +C + G +CD  +G+C C    +G  C  KC   T+G+     C   N ST       C+
Sbjct: 1015 ECSHLGNNCDPKTGRCICPPNTIGEKCS-KCAPNTWGHSITTGCKACNCSTVGSLDFQCN 1073

Query: 812  HITGTCYCSPGWKGARCDQ 830
              TG C C P + GA+C +
Sbjct: 1074 VNTGQCNCHPKFSGAKCTE 1092



 Score =  135 bits (340), Expect = 2e-31
 Identities = 136/520 (26%), Positives = 182/520 (35%), Gaps = 151/520 (29%)

Query: 42   VTVQESYPHPFDQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYES 101
            V +Q +Y    D I+  S  ++          VSY T    G         QC PG+  S
Sbjct: 684  VLLQITYSFGMDAIFRLSSVNL-------ESAVSYPT---DGSIAAAVEVCQCPPGYTGS 733

Query: 102  -----------------GEMCVP-HC---ADKC--VHGRCIAPNTCQCEPGWGGTNCSSA 138
                             G +C P  C   A+ C  V G C+      C+   GG  C   
Sbjct: 734  SCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECL-----NCKDHTGGPYCDKC 788

Query: 139  CDGDHWGP-----HCTSRCQCKNGALCNPITGACH-----------CAAGFRGWRCEDRC 182
              G +  P          C C      N  +  CH           C  G+ G RCE RC
Sbjct: 789  LPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCE-RC 847

Query: 183  EQGTYGN------DCHQRCQCQNG------ATCDHVTGECR-CPPGYTGAFCEDLCPPGK 229
             +G +G        C Q CQC +        +CD ++G C  C PG TG +CE LC  G 
Sbjct: 848  AEGYFGQPSVPGGSC-QPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCE-LCADGY 905

Query: 230  HGPQCE----QRCPCQNGG----VCHHVTGECSCPSGWMGTVCGQP-------------- 267
             G   +    Q C C  GG    VCH  TG+C C +   G  C +               
Sbjct: 906  FGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCV 965

Query: 268  ---------------------CPEGRFGKNCSQ--------------ECQC-HNGGTCDA 291
                                 C  G  GK C +               C+C H G  CD 
Sbjct: 966  PCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDP 1025

Query: 292  ATGQCHCSPGYTGERCQDECPVGTYG---VLCAETCQCVNGG----KCYHVSGACLCEAG 344
             TG+C C P   GE+C  +C   T+G       + C C   G    +C   +G C C   
Sbjct: 1026 KTGRCICPPNTIGEKC-SKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPK 1084

Query: 345  FAGERCEARLCPEGLYGIKCDKRCPCHLENTH-----------SCHPMSGECACKPGWSG 393
            F+G +C    C  G +       C C L  T            SC   +G+C CK    G
Sbjct: 1085 FSGAKCTE--CSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEG 1142

Query: 394  LYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPG 433
            ++C + C PG +G   +    C +   C   T +C+ A G
Sbjct: 1143 IHC-DRCRPGKFGLDAKNPLGC-SSCYCFGTTTQCSEAKG 1180



 Score =  128 bits (321), Expect = 4e-29
 Identities = 127/469 (27%), Positives = 175/469 (37%), Gaps = 97/469 (20%)

Query: 447  TYGINCSSRCGCKN--DAVCSPVDGS-------CTCKAGWHGVDCSIRCP-----SGTWG 492
            ++G++   R    N   AV  P DGS       C C  G+ G  C    P     +GT  
Sbjct: 691  SFGMDAIFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIF 750

Query: 493  FGCNLTCQCL-NGGACNTLDGTC-TCAPGWRGEKCELPCQDGTYG------LNCAERCDC 544
             G    CQC  +  +C+ + G C  C     G  C+  C  G YG          + C C
Sbjct: 751  GGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCD-KCLPGFYGEPTKGTSEDCQPCAC 809

Query: 545  S---HADGCHPTTGHCR--------CLPGWSGVHCDSVCAEGRWGP------NCSLPCYC 587
                 ++   PT    R        C  G++G  C+  CAEG +G       +C  PC C
Sbjct: 810  PLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCER-CAEGYFGQPSVPGGSCQ-PCQC 867

Query: 588  KNG------ASCSPDDGICE-CAPGFRGTTCQRICSPGFYGHRC-SQTCPQCVHSSGP-- 637
             +        SC    G C  C PG  G  C+ +C+ G++G    ++ C  C  ++G   
Sbjct: 868  NDNLDFSIPGSCDSLSGSCLICKPGTTGRYCE-LCADGYFGDAVDAKNCQPCRCNAGGSF 926

Query: 638  ---CHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRS------- 687
               CH  TG C+C     G  C++ C +G FG   A  C   N   CN            
Sbjct: 927  SEVCHSQTGQCECRANVQGQRCDK-CKAGTFGLQSARGCVPCN---CNSFGSKSFDCEES 982

Query: 688  --CQCYPGWIGSDCSQPCPPAHWG---PNCIHTCNC-HNGAFCSAYDGECKCTPGWTGLY 741
              C C PG  G  C + C   ++      C   C C H G  C    G C C P   G  
Sbjct: 983  GQCWCQPGVTGKKCDR-CAHGYFNFQEGGCT-ACECSHLGNNCDPKTGRCICPPNTIGEK 1040

Query: 742  CTQRCPLGFYGKDCALICQCQNGA-------DCDHISGQCTCRTGFMGRHCEQKCPSGTY 794
            C+ +C    +G      C+  N +        C+  +GQC C   F G  C + C  G +
Sbjct: 1041 CS-KCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTE-CSRGHW 1098

Query: 795  GYGCRQICDCLNNST-------------CDHITGTCYCSPGWKGARCDQ 830
             Y    +CDC    T             C   TG C C    +G  CD+
Sbjct: 1099 NYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDR 1147



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 70/242 (28%), Positives = 92/242 (38%), Gaps = 74/242 (30%)

Query: 209  ECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPC 268
            +C CP GY+G  CE  C PG +      R   Q GG           P   +GT      
Sbjct: 1379 KCDCPLGYSGLSCE-ACLPGFY------RLRSQPGG---------RTPGPTLGTCV---- 1418

Query: 269  PEGRFGKNCSQECQCH-NGGTCDAATGQC-HCSPGYTGERCQDECPVGTYGVLCA----- 321
                        CQC+ +   CD  T  C +C     G+ C+  C +G YG++       
Sbjct: 1419 -----------PCQCNGHSSLCDPETSICQNCQHHTAGDFCE-RCALGYYGIVKGLPNDC 1466

Query: 322  ETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPM 381
            + C C       + S +C+ E G    RC A  CP G  G  C++               
Sbjct: 1467 QQCACPLISSSNNFSPSCVAE-GLDDYRCTA--CPRGYEGQYCER--------------- 1508

Query: 382  SGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGAD----CDSVTGKCTCAPGFKGI 437
                 C PG++G       SPG  G +CQ+ C C         CD VTG CTC PG  G 
Sbjct: 1509 -----CAPGYTG-------SPGNPGGSCQE-CECDPYGSLPVPCDPVTGFCTCRPGATGR 1555

Query: 438  DC 439
             C
Sbjct: 1556 KC 1557



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 68/230 (29%), Positives = 91/230 (39%), Gaps = 60/230 (26%)

Query: 124  CQCEPGWGGTNCSSACDGDHW----------GPHCTS--RCQCK-NGALCNPITGAC-HC 169
            C C  G+ G +C +   G +           GP   +   CQC  + +LC+P T  C +C
Sbjct: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNC 1439

Query: 170  AAGFRGWRCEDRCEQGTYG------NDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCED 223
                 G  CE RC  G YG      NDC Q+C C   ++ ++ +  C    G     C  
Sbjct: 1440 QHHTAGDFCE-RCALGYYGIVKGLPNDC-QQCACPLISSSNNFSPSC-VAEGLDDYRCT- 1495

Query: 224  LCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQC 283
             CP G  G  CE+                  C  G+ G+        G  G +C QEC+C
Sbjct: 1496 ACPRGYEGQYCER------------------CAPGYTGS-------PGNPGGSC-QECEC 1529

Query: 284  HNGGT----CDAATGQCHCSPGYTGERCQDECP-----VGTYGVLCAETC 324
               G+    CD  TG C C PG TG +C D C       G   V C + C
Sbjct: 1530 DPYGSLPVPCDPVTGFCTCRPGATGRKC-DGCKHWHAREGWECVFCGDEC 1578



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 63/228 (27%), Positives = 74/228 (32%), Gaps = 67/228 (29%)

Query: 384  ECACKPGWSGLYCNETCSPGFYGEACQQ-------------ICSCQNGAD-CDSVTGKCT 429
            +C C  G+SGL C E C PGFY    Q               C C   +  CD  T  C 
Sbjct: 1379 KCDCPLGYSGLSC-EACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQ 1437

Query: 430  CAPGFKGIDCSTPCPLGTYGI-----NCSSRCGCKNDAVCSPVDGSCT-----------C 473
                    D    C LG YGI     N   +C C   +  +    SC            C
Sbjct: 1438 NCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497

Query: 474  KAGWHGVDCSIRCPSGTWGF-----GCNLTCQCLNGGA----CNTLDGTCTCAPGWRGEK 524
              G+ G  C  RC  G  G      G    C+C   G+    C+ + G CTC PG  G K
Sbjct: 1498 PRGYEGQYCE-RCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556

Query: 525  CELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVC 572
            C                      DGC     H     GW  V C   C
Sbjct: 1557 C----------------------DGCK----HWHAREGWECVFCGDEC 1578



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 61/213 (28%), Positives = 80/213 (37%), Gaps = 62/213 (29%)

Query: 645  CDCLPGFTGALCNEVCPSG--RFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQP 702
            CDC  G++G  C E C  G  R      G       GTC P    CQC      +  S  
Sbjct: 1380 CDCPLGYSGLSC-EACLPGFYRLRSQPGGRTPGPTLGTCVP----CQC------NGHSSL 1428

Query: 703  CPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYG------KDCA 756
            C P         T  C N            C     G +C +RC LG+YG       DC 
Sbjct: 1429 CDP--------ETSICQN------------CQHHTAGDFC-ERCALGYYGIVKGLPNDCQ 1467

Query: 757  LICQCQNGADCDHISGQCT-----------CRTGFMGRHCEQKCPS-----GTYGYGCRQ 800
              C C   +  ++ S  C            C  G+ G++CE+  P      G  G  C++
Sbjct: 1468 Q-CACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQE 1526

Query: 801  ICDCLNNST----CDHITGTCYCSPGWKGARCD 829
             C+C    +    CD +TG C C PG  G +CD
Sbjct: 1527 -CECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 56/219 (25%), Positives = 74/219 (33%), Gaps = 63/219 (28%)

Query: 671 GICTCTNNGTCNPIDRS-----CQCYPGWIGSDCSQPCPPAHWGP----------NCIHT 715
           G+C C  +    P+D +     C+C     G  C Q CP  H  P           C   
Sbjct: 285 GMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTEC-EA 343

Query: 716 CNCHNGAFCSAYD-------------------GEC-KCTPGWTGLYCTQRCPLGF----- 750
           CNCH  A    YD                   G C  CT    G+ C + C  GF     
Sbjct: 344 CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINC-ETCTDGFFRPKG 402

Query: 751 ----YGKDCALICQCQNGADCDHI-------------SGQCTCRTGFMGRHCEQKCPSGT 793
               Y + C   C C      + +              G C C+TGF G  C+ +C  G 
Sbjct: 403 VSPNYPRPCQ-PCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCD-RCARGY 460

Query: 794 YGYGCRQICDC--LNNSTCDHITGTCYCSPGWKGARCDQ 830
            GY   + C+C  L +   D   G C C    +G  C +
Sbjct: 461 TGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSR 499



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 55/182 (30%), Positives = 73/182 (40%), Gaps = 41/182 (22%)

Query: 514  CTCAPGWRGEKCELPCQDGTYGLNCAER-------------CDCS-HADGCHPTTGHCR- 558
            C C  G+ G  CE  C  G Y L                  C C+ H+  C P T  C+ 
Sbjct: 1380 CDCPLGYSGLSCEA-CLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438

Query: 559  CLPGWSGVHCDSVCAEGRWG-----PNCSLPCYC---KNGASCSP-------DDGICECA 603
            C    +G  C+  CA G +G     PN    C C    +  + SP       DD  C   
Sbjct: 1439 CQHHTAGDFCER-CALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497

Query: 604  P-GFRGTTCQRICSPGFYGHRCSQ--TCPQCVHSSG-----PCHHITGLCDCLPGFTGAL 655
            P G+ G  C+R C+PG+ G   +   +C +C          PC  +TG C C PG TG  
Sbjct: 1498 PRGYEGQYCER-CAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRK 1556

Query: 656  CN 657
            C+
Sbjct: 1557 CD 1558



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 69/270 (25%), Positives = 94/270 (34%), Gaps = 53/270 (19%)

Query: 332 CYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCP----------CHLENTH----S 377
           CY  + AC  +      RCE   C     G  CD+ CP            L  T     +
Sbjct: 289 CYGHARACPLDPATNKSRCE---CEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACN 345

Query: 378 CHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQN--GADCDSVTGKCTCAPGF- 434
           CH  + EC      +    +      + G      C+ QN  G +C+      TC  GF 
Sbjct: 346 CHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCT-QNTAGINCE------TCTDGFF 398

Query: 435 --KGIDCS-----TPC---PLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSI 484
             KG+  +      PC   P+G+    C      +  A      GSC CK G+ GV C  
Sbjct: 399 RPKGVSPNYPRPCQPCHCDPIGSLNEVCVKD---EKHARRGLAPGSCHCKTGFGGVSCD- 454

Query: 485 RCPSGTWGFGCNLTCQCLNGGACN--TLDGTCTCAPGWRGEKCELPCQDGTYGL-----N 537
           RC  G  G+     C C   G+ N     G C C     G  C   C+ G + L      
Sbjct: 455 RCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCS-RCKSGFFNLQEDNWK 513

Query: 538 CAERCDCS----HADGCHPTTGHCRCLPGW 563
             + C CS         + T G  + + GW
Sbjct: 514 GCDECFCSGVSNRCQSSYWTYGKIQDMSGW 543



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 73/301 (24%), Positives = 100/301 (33%), Gaps = 60/301 (19%)

Query: 450 INCSSRCGCKNDAVCSPVDGS-----CTCKAGWHGVDCSIRCPS---GTWGFGCNLT-CQ 500
           I+    C C   A   P+D +     C C+    G  C   CP      W  G  LT  +
Sbjct: 281 ISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTE 340

Query: 501 CLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHC-RC 559
           C    ACN                C    ++  Y  N A R    +  G +   G C  C
Sbjct: 341 C---EACN----------------CHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINC 381

Query: 560 LPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGF 619
               +G++C++ C +G + P    P Y +    C P    C C P             G 
Sbjct: 382 TQNTAGINCET-CTDGFFRPKGVSPNYPR---PCQP----CHCDP------------IGS 421

Query: 620 YGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNG 679
               C +          P     G C C  GF G  C+  C  G  G      C C+  G
Sbjct: 422 LNEVCVKDEKHARRGLAP-----GSCHCKTGFGGVSCDR-CARGYTGYPDCKACNCSGLG 475

Query: 680 TCN--PIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGW 737
           + N  P    C C     G DCS+ C    +     +   C +  FCS     C+ +  W
Sbjct: 476 SKNEDPCFGPCICKENVEGGDCSR-CKSGFFNLQEDNWKGC-DECFCSGVSNRCQ-SSYW 532

Query: 738 T 738
           T
Sbjct: 533 T 533



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 65/232 (28%), Positives = 78/232 (33%), Gaps = 57/232 (24%)

Query: 413 CSCQN---GADCDSVTGKCTCAPGFKGIDCSTPCPLGTY-------GINCSSRCG-CKND 461
           C C++   G  CD       C PGF       P   GT+         NC  +   C  D
Sbjct: 307 CECEHNTCGDSCDQ------CCPGFH----QKPWRAGTFLTKTECEACNCHGKAEECYYD 356

Query: 462 AVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWR 521
              +  + S   +  + G    I C   T G  C                   TC  G+ 
Sbjct: 357 ENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCE------------------TCTDGFF 398

Query: 522 GEK-----CELPCQ----DGTYGLNCAERCDCSHAD-GCHPTTGHCRCLPGWSGVHCDSV 571
             K        PCQ    D    LN     D  HA  G  P  G C C  G+ GV CD  
Sbjct: 399 RPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAP--GSCHCKTGFGGVSCDR- 455

Query: 572 CAEGRWG-PNCSLPCYCKNGASCSPDD--GICECAPGFRGTTCQRICSPGFY 620
           CA G  G P+C   C C    S + D   G C C     G  C R C  GF+
Sbjct: 456 CARGYTGYPDCK-ACNCSGLGSKNEDPCFGPCICKENVEGGDCSR-CKSGFF 505



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 47/182 (25%), Positives = 59/182 (32%), Gaps = 57/182 (31%)

Query: 93  QCCPGFYESG------------EMCVPH-CADKC--------------VHGRCIAPNTC- 124
           QCCPGF++              E C  H  A++C              + G+ I    C 
Sbjct: 320 QCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCI 379

Query: 125 QCEPGWGGTNCSSACDG----DHWGPHCTSRCQCKNGALCNPI----------------- 163
            C     G NC +  DG        P+    CQ      C+PI                 
Sbjct: 380 NCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQ---PCHCDPIGSLNEVCVKDEKHARRG 436

Query: 164 --TGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQ--NGATCDHVTGECRCPPGYTGA 219
              G+CHC  GF G  C DRC +G  G    + C C        D   G C C     G 
Sbjct: 437 LAPGSCHCKTGFGGVSC-DRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGG 495

Query: 220 FC 221
            C
Sbjct: 496 DC 497



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 36/120 (30%), Positives = 46/120 (38%), Gaps = 17/120 (14%)

Query: 95  CPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQC 154
           C       E+CV    D+    R +AP +C C+ G+GG +C     G    P C + C C
Sbjct: 416 CDPIGSLNEVCVK---DEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKA-CNC 471

Query: 155 KNGALCN--PITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRC 212
                 N  P  G C C     G  C  RC+ G +        Q  N   CD    EC C
Sbjct: 472 SGLGSKNEDPCFGPCICKENVEGGDC-SRCKSGFF------NLQEDNWKGCD----ECFC 520



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 69/272 (25%), Positives = 83/272 (30%), Gaps = 76/272 (27%)

Query: 102 GEMCVPHC-ADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGP----------HCTS 150
           G MC+ +  A  C        + C+CE    G +C   C G H  P           C +
Sbjct: 284 GGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEA 343

Query: 151 RCQCKNGA-------------LCNPITG-------ACHCAAGFRGWRCEDRCEQG----- 185
            C C   A             L   I G         +C     G  CE  C  G     
Sbjct: 344 -CNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCE-TCTDGFFRPK 401

Query: 186 ----TYGNDCHQRCQCQNGATCDHV-------------TGECRCPPGYTGAFCEDLCPPG 228
                Y   C Q C C    + + V              G C C  G+ G  C D C  G
Sbjct: 402 GVSPNYPRPC-QPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSC-DRCARG 459

Query: 229 KHG-PQCEQRCPCQNGGVCHH--VTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHN 285
             G P C + C C   G  +     G C C     G  C + C  G F        Q  N
Sbjct: 460 YTGYPDC-KACNCSGLGSKNEDPCFGPCICKENVEGGDCSR-CKSGFF------NLQEDN 511

Query: 286 GGTCDAATGQCHCSPGYTGERCQDECPVGTYG 317
              CD    +C CS      RCQ      TYG
Sbjct: 512 WKGCD----ECFCSG--VSNRCQSS--YWTYG 535



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 38/157 (24%), Positives = 61/157 (38%), Gaps = 35/157 (22%)

Query: 730  ECKCTPGWTGLYCTQRCPLGFY-------GK------DCALICQCQNGAD-CDHISGQC- 774
            +C C  G++GL C + C  GFY       G+         + CQC   +  CD  +  C 
Sbjct: 1379 KCDCPLGYSGLSC-EACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQ 1437

Query: 775  TCRTGFMGRHCEQKCPSGTYGY------GCRQICDCLNNSTCDHITGTCY---------- 818
             C+    G  CE +C  G YG        C+Q C C   S+ ++ + +C           
Sbjct: 1438 NCQHHTAGDFCE-RCALGYYGIVKGLPNDCQQ-CACPLISSSNNFSPSCVAEGLDDYRCT 1495

Query: 819  -CSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSY 854
             C  G++G  C++      G+  +   +      D Y
Sbjct: 1496 ACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPY 1532



 Score = 35.0 bits (79), Expect = 0.41
 Identities = 28/96 (29%), Positives = 36/96 (37%), Gaps = 14/96 (14%)

Query: 93   QCCPGFYESGEMCVPHC-ADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPH---- 147
            QC      S     P C A+     RC A     C  G+ G  C     G    P     
Sbjct: 1468 QCACPLISSSNNFSPSCVAEGLDDYRCTA-----CPRGYEGQYCERCAPGYTGSPGNPGG 1522

Query: 148  CTSRCQCKN-GAL---CNPITGACHCAAGFRGWRCE 179
                C+C   G+L   C+P+TG C C  G  G +C+
Sbjct: 1523 SCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score =  178 bits (452), Expect = 2e-44
 Identities = 196/763 (25%), Positives = 283/763 (37%), Gaps = 188/763 (24%)

Query: 124  CQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCE 183
            C C   + G  C    D      +C          LC  ++  C+C+   R  R  + CE
Sbjct: 590  CSCSLSYIGRLCVVNVD------YCLGNHSISVHGLCLALSHNCNCSGLQRYER--NICE 641

Query: 184  QGTYGNDCHQRCQCQNGATCDHVTGEC--RCPPGYTGAFCE-DLCPPGKHGPQCEQRCPC 240
              T   DC +   C+NG T  H+ G    +C PG+ G  CE D+     H        PC
Sbjct: 642  IDT--EDC-KSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASH--------PC 690

Query: 241  QNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSP 300
            +NG  C    G   C                     C    +  +G +C        C+P
Sbjct: 691  KNGATCIDQPGNYFC--------------------QCVPPFKVVDGFSC-------LCNP 723

Query: 301  GYTGERCQ---DECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPE 357
            GY G RC+   D+C +      C     C    K  H+S  C+C + + G  CE      
Sbjct: 724  GYVGIRCEQDIDDCILNA----CEHNSTC----KDLHLSYQCVCLSDWEGNFCEQE---- 771

Query: 358  GLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQN 417
                 +C K  PC   +T +    S  C C  GW+G  C+E  +       C     C N
Sbjct: 772  ---SNEC-KMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINE------CDSD-PCMN 820

Query: 418  GADC--DSVTGK--CTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVC-SPVDGS-- 470
            G  C   ++ G+  C C P + G  C        Y +       C+N++ C + VD +  
Sbjct: 821  GGLCHESTIPGQFVCLCPPLYTGQFCHQ-----RYNLCDLLHNPCRNNSTCLALVDANQH 875

Query: 471  CTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGT--CTCAPGWRGEKCEL- 527
            C C+  + G +C I          C L   C + G C  +     C C PG+ G  CE+ 
Sbjct: 876  CICREEFEGKNCEIDVKD------C-LFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIE 928

Query: 528  -------PCQDGTYGLNCAER--CDCS---HADGCHPTTGHCRCLPGWSGVHC------- 568
                   PC++    ++   R  C+C    H   C      C+  P     +C       
Sbjct: 929  INECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGY 988

Query: 569  DSVCAEGRWGPNCSLPCYCKNGASCSPD----DGICECAPGFRGTTCQRICSPGFYGHRC 624
            + +CA G  G NC +     N   C  +    DG+C    G    TC   C  GF+G  C
Sbjct: 989  NCLCAPGYTGINCEI-----NLDECLSEPCLHDGVC--IDGINHYTCD--CKSGFFGTHC 1039

Query: 625  SQTCPQCVHSSGPCHH--ITGL-----CDCLPGFTGALCNEVCPSGRFGKNCAGICTCTN 677
                  C+  S PC H   T L     C C    T   C           +C  I  C N
Sbjct: 1040 ETNANDCL--SNPCLHGRCTELINEYPCSCDADGTSTQCKIKI------NDCTSI-PCMN 1090

Query: 678  NGTCNPIDR--SCQCYPGWIGSDCSQPCPPAHWGPNC----IHTCNCHNGAFCSAYDG-- 729
             G C       +C C  G+ G+ C +         NC    +++  C NG  C    G  
Sbjct: 1091 EGFCQKSAHGFTCICPRGYTGAYCEKSID------NCAEPELNSVICLNGGICVDGPGHT 1144

Query: 730  -ECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADC-DHISGQ-CTCRTGFMGRHCE 786
             +C+C PG++G +C           +C+    C +GADC DHI+G  C C+ G+ G HCE
Sbjct: 1145 FDCRCLPGFSGQFCEINI------NECSS-SPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197

Query: 787  QKCPSGTYGYGCRQICDCLNNSTCDHIT------GTCYCSPGW 823
             +              +C+ NS    +        TC C+PG+
Sbjct: 1198 NE-------------LECIPNSCVHELCMENEPGSTCLCTPGF 1227



 Score =  156 bits (395), Expect = 9e-38
 Identities = 220/927 (23%), Positives = 317/927 (34%), Gaps = 228/927 (24%)

Query: 33  VCSHWES----YSVTVQESYPHPFD-------QIYYTSCTDILNWFKCTRHRVSYRTAYR 81
           V S W S    Y +TV  S P P          +    C + L+   C+ H      A+ 
Sbjct: 136 VNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAW- 194

Query: 82  HGEKTMYRRKSQCCPGFYESGEMC--VPHCADKCV--HGRCIAPNT--------CQCEPG 129
              KT       C P F  SG+ C  +  C+ K    +G CI            C C P 
Sbjct: 195 --SKTY---SCHCQPPF--SGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPP 247

Query: 130 WGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCE------ 183
           + G NCS         PH      C N       +  C C   F G  CE   +      
Sbjct: 248 FTGKNCSEII--GQCQPHVCFHGNCSN---ITSNSFICECDEQFSGPFCEVSAKPCVSLL 302

Query: 184 ----------QGTYGNDCHQRCQ---------------CQNGATCDHVTGE--CRCPPGY 216
                        Y  +C +                  CQNG  C  ++ +  C C P +
Sbjct: 303 FWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIF 362

Query: 217 TGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGE--CSCPSGWMGTVCGQPCPEGR-F 273
           T   C+ +         CE   P +N   C     +  CSC SG+    C +     +  
Sbjct: 363 TDLLCKSI------QTSCES-FPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLL 415

Query: 274 GKNCSQECQCHNGGTCDAATGQCHCSPGYTGERC---QDECPVGTYGVLCAETCQ--CVN 328
             NC  E  C N         +  C PG T   C   ++   +  +   C  T    C +
Sbjct: 416 SINCLNEEWCFN----IIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQD 471

Query: 329 GGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACK 388
            G         L  AG  GE+C+  +         C +      + T+   P     +C 
Sbjct: 472 KGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTE------DATYVNDPEDNNSSC- 524

Query: 389 PGWSGLYCNETCSPGFYGEACQQICSCQNGADC----DSVTGKCTCAPGFKGIDCSTPCP 444
             W            F  E  ++IC+  NG  C    DS   +  C   + G        
Sbjct: 525 --W------------FPHEGTKEICA--NGCSCLSEEDSQEYRYLCFLRWAG-------N 561

Query: 445 LGTYGINCSSRCGCKNDAVCSPVDG--SCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCL 502
           +            C+++AVC        C+C   + G  C +           ++     
Sbjct: 562 MYLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISV----- 616

Query: 503 NGGACNTLDGTCTCAPGWRGEK--CELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCL 560
             G C  L   C C+   R E+  CE+  +D     +C      +H  G        +C+
Sbjct: 617 -HGLCLALSHNCNCSGLQRYERNICEIDTED-CKSASCKNGTTSTHLRGYF----FRKCV 670

Query: 561 PGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASC--SPDDGICECAPGFR---GTTCQRIC 615
           PG+ G  C+    E    P       CKNGA+C   P +  C+C P F+   G +C  +C
Sbjct: 671 PGFKGTQCEIDIDECASHP-------CKNGATCIDQPGNYFCQCVPPFKVVDGFSC--LC 721

Query: 616 SPGFYGHRCSQTCPQCV------HSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNC 669
           +PG+ G RC Q    C+      +S+    H++  C CL  + G  C +         N 
Sbjct: 722 NPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQ-------ESNE 774

Query: 670 AGICTCTNNGTCNPIDRS--CQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFC--S 725
             +  C NN TC  + +S  C+C  GW G +CS+        P       C NG  C  S
Sbjct: 775 CKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDP-------CMNGGLCHES 827

Query: 726 AYDGE--CKCTPGWTGLYCTQR----------------------------CPLGFYGKDC 755
              G+  C C P +TG +C QR                            C   F GK+C
Sbjct: 828 TIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNC 887

Query: 756 ------ALICQCQNGADCDHI--SGQCTCRTGFMGRHCE---QKCPSGTYGYGCRQICDC 804
                  L   CQ+  DC+ +  + +C CR GF G  CE    +C S            C
Sbjct: 888 EIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSE----------PC 937

Query: 805 LNNSTCDHITGT--CYCSPGWKGARCD 829
            NN TC  +T    C C P + G  C+
Sbjct: 938 KNNGTCVDLTNRFFCNCEPEYHGPFCE 964



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 26/80 (32%), Positives = 37/80 (46%), Gaps = 13/80 (16%)

Query: 671  GICTCTNNGTC--NPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFC---S 725
            G  TC N G C  N    SC+C P W G+ C+Q         +C++   C + + C    
Sbjct: 2880 GYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQ-------SVSCLNNL-CLHQSLCIPDQ 2931

Query: 726  AYDGECKCTPGWTGLYCTQR 745
            ++   C CT GW G YC  +
Sbjct: 2932 SFSYSCLCTLGWVGRYCENK 2951



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 29/77 (37%), Positives = 36/77 (46%), Gaps = 12/77 (15%)

Query: 675  CTNNGTCNPIDRS--CQCYPGWIGSDCSQ---PCPPAHWGPNCIHTCNCHNGAFCSA--Y 727
            C N GTC     S  C C  GW GS C++    C P H  P+     +C  GA C +  +
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPH-----HCSRGATCISLPH 2673

Query: 728  DGECKCTPGWTGLYCTQ 744
               C C  G TG+YC Q
Sbjct: 2674 GYTCFCPLGTTGIYCEQ 2690



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 27/72 (37%), Positives = 30/72 (41%), Gaps = 13/72 (18%)

Query: 116  GRCIAPNT---CQCEPGWGGTNCS---SACDGDHWGPHCTSRCQCKNGALC--NPITGAC 167
            G CI   T   C C  GW G+ C+   S CD +H  PH      C  GA C   P    C
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPH-----HCSRGATCISLPHGYTC 2677

Query: 168  HCAAGFRGWRCE 179
             C  G  G  CE
Sbjct: 2678 FCPLGTTGIYCE 2689



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 25/76 (32%), Positives = 32/76 (42%), Gaps = 15/76 (19%)

Query: 501  CLNGGACNTLDGT---CTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTG-- 555
            C NGG C T++GT   C C P W G  C          ++C     C H   C P     
Sbjct: 2884 CRNGGEC-TVNGTTFSCRCLPDWAGNTC-------NQSVSCLNNL-CLHQSLCIPDQSFS 2934

Query: 556  -HCRCLPGWSGVHCDS 570
              C C  GW G +C++
Sbjct: 2935 YSCLCTLGWVGRYCEN 2950



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 29/94 (30%), Positives = 36/94 (38%), Gaps = 18/94 (19%)

Query: 180  DRCEQGTYGNDCH----QRCQCQNGATC--DHVTGECRCPPGYTGAFCEDLCPPGKHGPQ 233
            D    G    +CH        C+N  TC  D+    C CP  Y+G  C+           
Sbjct: 2323 DEARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--------FAS 2374

Query: 234  CEQRCPCQNGGVCHHVTGE---CSCPSGWMGTVC 264
            CE   PC NG  C   +G    C CP G  G +C
Sbjct: 2375 CENN-PCGNGATCVPKSGTDIVCLCPYGRSGPLC 2407



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 35/113 (30%), Positives = 40/113 (35%), Gaps = 29/113 (25%)

Query: 343  AGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNE---T 399
            AG +  +C A  C      +KC     C    T      S  C C  GW G +C E   T
Sbjct: 2602 AGRSVGQCHASPCSL----MKCGNGGTCIESGT------SVYCNCTTGWKGSFCTETVST 2651

Query: 400  CSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINC 452
            C P            C  GA C S+    TC            CPLGT GI C
Sbjct: 2652 CDPEH-----DPPHHCSRGATCISLPHGYTCF-----------CPLGTTGIYC 2688



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 27/80 (33%), Positives = 33/80 (41%), Gaps = 16/80 (20%)

Query: 196  QCQNGATC--DHVTGECRCPPGYTGAFCED---LCPPGKHGPQCEQRCPCQNGGVC---- 246
            +C NG TC     +  C C  G+ G+FC +    C P +H P       C  G  C    
Sbjct: 2618 KCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDP-EHDPPHH----CSRGATCISLP 2672

Query: 247  HHVTGECSCPSGWMGTVCGQ 266
            H  T  C CP G  G  C Q
Sbjct: 2673 HGYT--CFCPLGTTGIYCEQ 2690



 Score = 38.9 bits (89), Expect = 0.028
 Identities = 25/74 (33%), Positives = 29/74 (39%), Gaps = 6/74 (8%)

Query: 718  CHNGAFC--SAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHI--SGQ 773
            C NG  C  S     C CT GW G +CT+         D      C  GA C  +     
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPP--HHCSRGATCISLPHGYT 2676

Query: 774  CTCRTGFMGRHCEQ 787
            C C  G  G +CEQ
Sbjct: 2677 CFCPLGTTGIYCEQ 2690



 Score = 38.9 bits (89), Expect = 0.028
 Identities = 24/81 (29%), Positives = 31/81 (38%), Gaps = 13/81 (16%)

Query: 718  CHNGAFCSAYDG--ECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADC---DHISG 772
            C NG  C+       C+C P W G  C Q            L   C + + C      S 
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS--------CLNNLCLHQSLCIPDQSFSY 2935

Query: 773  QCTCRTGFMGRHCEQKCPSGT 793
             C C  G++GR+CE K    T
Sbjct: 2936 SCLCTLGWVGRYCENKTSFST 2956



 Score = 38.5 bits (88), Expect = 0.037
 Identities = 24/77 (31%), Positives = 34/77 (44%), Gaps = 6/77 (7%)

Query: 150  SRCQCKNGALC--NPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVT 207
            S  +C NG  C  +  +  C+C  G++G  C +        +D    C    GATC  + 
Sbjct: 2615 SLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCS--RGATCISLP 2672

Query: 208  G--ECRCPPGYTGAFCE 222
                C CP G TG +CE
Sbjct: 2673 HGYTCFCPLGTTGIYCE 2689



 Score = 38.5 bits (88), Expect = 0.037
 Identities = 23/85 (27%), Positives = 36/85 (42%), Gaps = 13/85 (15%)

Query: 414  SCQNGADC--DSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDG-- 469
            +C+NG +C  +  T  C C P + G  C+         ++C +   C + ++C P     
Sbjct: 2883 TCRNGGECTVNGTTFSCRCLPDWAGNTCNQ-------SVSCLNNL-CLHQSLCIPDQSFS 2934

Query: 470  -SCTCKAGWHGVDCSIRCPSGTWGF 493
             SC C  GW G  C  +    T  F
Sbjct: 2935 YSCLCTLGWVGRYCENKTSFSTAKF 2959



 Score = 38.1 bits (87), Expect = 0.048
 Identities = 23/78 (29%), Positives = 31/78 (39%), Gaps = 7/78 (8%)

Query: 553  TTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASC--SPDDGICECAPGFRGTT 610
            T+ +C C  GW G  C    +     P    P +C  GA+C   P    C C  G  G  
Sbjct: 2630 TSVYCNCTTGWKGSFCTETVS--TCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIY 2687

Query: 611  CQR---ICSPGFYGHRCS 625
            C++   I  P F  +  S
Sbjct: 2688 CEQALSISDPSFRSNELS 2705



 Score = 37.7 bits (86), Expect = 0.063
 Identities = 27/89 (30%), Positives = 35/89 (39%), Gaps = 23/89 (25%)

Query: 240  CQNGGVCHH--VTGECSCPSGWMGTVCGQPCPEGRFGKNCSQE----CQCHNGGTCDAAT 293
            C NGG C     +  C+C +GW G+ C +          C  E      C  G TC    
Sbjct: 2619 CGNGGTCIESGTSVYCNCTTGWKGSFCTETV------STCDPEHDPPHHCSRGATC---- 2668

Query: 294  GQCHCSPGYTGERCQDECPVGTYGVLCAE 322
                   GYT   C   CP+GT G+ C +
Sbjct: 2669 --ISLPHGYT---C--FCPLGTTGIYCEQ 2690



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 26/93 (27%), Positives = 37/93 (39%), Gaps = 23/93 (24%)

Query: 751  YGKDCALICQCQNGADC--DHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICD----- 803
            +   C+L+ +C NG  C     S  C C TG+ G  C +   +          CD     
Sbjct: 2610 HASPCSLM-KCGNGGTCIESGTSVYCNCTTGWKGSFCTETVST----------CDPEHDP 2658

Query: 804  ---CLNNSTCDHITG--TCYCSPGWKGARCDQA 831
               C   +TC  +    TC+C  G  G  C+QA
Sbjct: 2659 PHHCSRGATCISLPHGYTCFCPLGTTGIYCEQA 2691



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 28/102 (27%), Positives = 38/102 (37%), Gaps = 9/102 (8%)

Query: 260  MGTVCGQPCPEGRFGKNCSQEC---QCHNGGTC--DAATGQCHCSPGYTGERCQDECPVG 314
            +G   G P      G+  +  C   +C NGGTC     +  C+C+ G+ G  C +   V 
Sbjct: 2593 LGNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTE--TVS 2650

Query: 315  TYGVLCAETCQCVNGGKCYHV--SGACLCEAGFAGERCEARL 354
            T          C  G  C  +     C C  G  G  CE  L
Sbjct: 2651 TCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQAL 2692



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 29/114 (25%), Positives = 38/114 (33%), Gaps = 29/114 (25%)

Query: 292  ATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYH--VSGACLCEAGFAGER 349
            + GQCH SP                        +C NGG C     S  C C  G+ G  
Sbjct: 2605 SVGQCHASP--------------------CSLMKCGNGGTCIESGTSVYCNCTTGWKGS- 2643

Query: 350  CEARLCPEGLYGIKCDKRCPCHLENTHSCH--PMSGECACKPGWSGLYCNETCS 401
                 C E +     +   P H     +C   P    C C  G +G+YC +  S
Sbjct: 2644 ----FCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALS 2693



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 24/77 (31%), Positives = 32/77 (41%), Gaps = 19/77 (24%)

Query: 544  CSHADGC--HPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPC---YCKNGASCSPDDG 598
            C +   C  + TT  CRCLP W+G  C           N S+ C    C + + C PD  
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWAGNTC-----------NQSVSCLNNLCLHQSLCIPDQS 2932

Query: 599  I---CECAPGFRGTTCQ 612
                C C  G+ G  C+
Sbjct: 2933 FSYSCLCTLGWVGRYCE 2949



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 26/80 (32%), Positives = 32/80 (40%), Gaps = 13/80 (16%)

Query: 763  NGADCDHIS-GQCTCRTG----FMGRHCEQKCPSGTYGYGCRQICDCLNN-----STC-- 810
            N  DCD  + G  TCR G      G     +C     G  C Q   CLNN     S C  
Sbjct: 2870 NVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIP 2929

Query: 811  -DHITGTCYCSPGWKGARCD 829
                + +C C+ GW G  C+
Sbjct: 2930 DQSFSYSCLCTLGWVGRYCE 2949



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 26/89 (29%), Positives = 34/89 (38%), Gaps = 14/89 (15%)

Query: 581  CSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHH 640
            CSL   C NG +C              GT+    C+ G+ G  C++T   C     P HH
Sbjct: 2614 CSL-MKCGNGGTCIES-----------GTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHH 2661

Query: 641  ITGLCDCLPGFTGALCNEVCPSGRFGKNC 669
             +    C+    G  C   CP G  G  C
Sbjct: 2662 CSRGATCISLPHGYTC--FCPLGTTGIYC 2688



 Score = 35.0 bits (79), Expect = 0.41
 Identities = 29/104 (27%), Positives = 39/104 (37%), Gaps = 31/104 (29%)

Query: 131  GGTNCSSACDGDHWGPHCTSRCQCKNGALC--NPITGACHCAAGFRGWRCEDRCEQGTYG 188
            GG+N    CDG   G +      C+NG  C  N  T +C C   + G             
Sbjct: 2867 GGSNVGD-CDGTACGYNT-----CRNGGECTVNGTTFSCRCLPDWAG------------- 2907

Query: 189  NDCHQRCQCQNGATCDH---------VTGECRCPPGYTGAFCED 223
            N C+Q   C N   C H          +  C C  G+ G +CE+
Sbjct: 2908 NTCNQSVSCLNNL-CLHQSLCIPDQSFSYSCLCTLGWVGRYCEN 2950



 Score = 33.9 bits (76), Expect = 0.91
 Identities = 20/78 (25%), Positives = 30/78 (38%), Gaps = 7/78 (8%)

Query: 240  CQNGGVC--HHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCH 297
            C+NGG C  +  T  C C   W G  C Q          C  +  C       + +  C 
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWAGNTCNQSV--SCLNNLCLHQSLCIPD---QSFSYSCL 2938

Query: 298  CSPGYTGERCQDECPVGT 315
            C+ G+ G  C+++    T
Sbjct: 2939 CTLGWVGRYCENKTSFST 2956



 Score = 33.9 bits (76), Expect = 0.91
 Identities = 23/79 (29%), Positives = 28/79 (35%), Gaps = 12/79 (15%)

Query: 326  CVNGGKCYHVSG---ACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMS 382
            C NGG+C  V+G   +C C   +AG  C           + C      H          S
Sbjct: 2884 CRNGGECT-VNGTTFSCRCLPDWAGNTCNQ--------SVSCLNNLCLHQSLCIPDQSFS 2934

Query: 383  GECACKPGWSGLYCNETCS 401
              C C  GW G YC    S
Sbjct: 2935 YSCLCTLGWVGRYCENKTS 2953



 Score = 33.9 bits (76), Expect = 0.91
 Identities = 21/77 (27%), Positives = 32/77 (41%), Gaps = 14/77 (18%)

Query: 116  GRCIAPNT---CQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNP---ITGACHC 169
            G C    T   C+C P W G  C+ +         C +   C + +LC P    + +C C
Sbjct: 2888 GECTVNGTTFSCRCLPDWAGNTCNQSVS-------CLNNL-CLHQSLCIPDQSFSYSCLC 2939

Query: 170  AAGFRGWRCEDRCEQGT 186
              G+ G  CE++    T
Sbjct: 2940 TLGWVGRYCENKTSFST 2956



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 25/88 (28%), Positives = 33/88 (37%), Gaps = 25/88 (28%)

Query: 495  CNLTCQCLNGGACNTLDGT---CTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCH 551
            C+L  +C NGG C    GT   C C  GW+G  C                CD  H    H
Sbjct: 2614 CSLM-KCGNGGTCIE-SGTSVYCNCTTGWKGSFC----------TETVSTCDPEHDPPHH 2661

Query: 552  PTTG----------HCRCLPGWSGVHCD 569
             + G           C C  G +G++C+
Sbjct: 2662 CSRGATCISLPHGYTCFCPLGTTGIYCE 2689



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 8/41 (19%)

Query: 277  CSQECQCHNGGTCDA-------ATGQCHCSPGYTGERCQDE 310
            C Q+  CHNGGTC A        + QC C   +TG  C+ +
Sbjct: 2103 CQQDV-CHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 27/94 (28%), Positives = 34/94 (36%), Gaps = 16/94 (17%)

Query: 445  LGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGW----HGVDCSIRCPSGTWGFGCNLTCQ 500
            L  +G    S  G  +   C    G  TC+ G     +G   S RC     G  CN +  
Sbjct: 2860 LTEFGAKGGSNVGDCDGTAC----GYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS 2915

Query: 501  CLNG-----GAC---NTLDGTCTCAPGWRGEKCE 526
            CLN        C    +   +C C  GW G  CE
Sbjct: 2916 CLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 22/79 (27%), Positives = 28/79 (35%), Gaps = 25/79 (31%)

Query: 197  CQNGATC--DHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHH------ 248
            C+NG  C  +  T  CRC P +              G  C Q   C N  +C H      
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWA-------------GNTCNQSVSCLN-NLCLHQSLCIP 2929

Query: 249  ---VTGECSCPSGWMGTVC 264
                +  C C  GW+G  C
Sbjct: 2930 DQSFSYSCLCTLGWVGRYC 2948



 Score = 32.3 bits (72), Expect = 2.6
 Identities = 23/73 (31%), Positives = 31/73 (42%), Gaps = 10/73 (13%)

Query: 789  CPSGTYGYG-CRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLS-RTS 846
            C     GY  CR   +C  N T    T +C C P W G  C+Q+    V  LN+L    S
Sbjct: 2874 CDGTACGYNTCRNGGECTVNGT----TFSCRCLPDWAGNTCNQS----VSCLNNLCLHQS 2925

Query: 847  TALPADSYQIGAI 859
              +P  S+    +
Sbjct: 2926 LCIPDQSFSYSCL 2938



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 23/76 (30%), Positives = 29/76 (38%), Gaps = 16/76 (21%)

Query: 154  CKNGALC--NPITGACHCAAGFRGWRCE-DRCEQGTYGNDCHQRCQCQNGATCDHVTGE- 209
            C+N   C  +     C C   + G  C+   CE             C NGATC   +G  
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQFASCENNP----------CGNGATCVPKSGTD 2393

Query: 210  --CRCPPGYTGAFCED 223
              C CP G +G  C D
Sbjct: 2394 IVCLCPYGRSGPLCTD 2409



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 18/58 (31%), Positives = 23/58 (39%), Gaps = 11/58 (18%)

Query: 645  CDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNP---IDRSCQCYPGWIGSDC 699
            C CLP + G  CN+         +C     C +   C P      SC C  GW+G  C
Sbjct: 2899 CRCLPDWAGNTCNQ-------SVSCLN-NLCLHQSLCIPDQSFSYSCLCTLGWVGRYC 2948



 Score = 31.6 bits (70), Expect = 4.5
 Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 7/37 (18%)

Query: 193  QRCQCQNGATCDH-------VTGECRCPPGYTGAFCE 222
            Q+  C NG TC         V+ +C CP  +TG FCE
Sbjct: 2104 QQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140



 Score = 31.2 bits (69), Expect = 5.9
 Identities = 21/74 (28%), Positives = 29/74 (39%), Gaps = 13/74 (17%)

Query: 587  CKNGASCSPDDGI--CECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSS--GPCHHIT 642
            C+NG  C+ +     C C P + G TC +  S       C      C+H S   P    +
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-------CLNNL--CLHQSLCIPDQSFS 2934

Query: 643  GLCDCLPGFTGALC 656
              C C  G+ G  C
Sbjct: 2935 YSCLCTLGWVGRYC 2948



 Score = 30.8 bits (68), Expect = 7.7
 Identities = 15/45 (33%), Positives = 19/45 (42%), Gaps = 7/45 (15%)

Query: 227  PGKHGPQCEQRCPCQNGGVCHH-------VTGECSCPSGWMGTVC 264
            P    P   Q+  C NGG CH        V+ +C CP  + G  C
Sbjct: 2095 PSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFC 2139


>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
          Length = 3075

 Score =  175 bits (443), Expect = 3e-43
 Identities = 153/485 (31%), Positives = 197/485 (40%), Gaps = 108/485 (22%)

Query: 124  CQCEPGWGGTNCSSAC------DGDHWGPHCTSRCQCK-NGALCNPITGAC-HCAAGFRG 175
            C+C  G+ GT+C S        DG  +G  C   C+C  + A CN + G C  CA    G
Sbjct: 709  CECPQGYTGTSCESCLSGYYRVDGILFGGICQP-CECHGHAAECN-VHGVCIACAHNTTG 766

Query: 176  WRCEDRCEQGTYGN-------DCHQRCQCQNGATCDHVTGECR-----------CPPGYT 217
              CE +C  G YG        DC Q C C      ++ +  C            C PGY+
Sbjct: 767  VHCE-QCLPGFYGEPSRGTPGDC-QPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYS 824

Query: 218  GAFCEDLCPPGKHGPQC---EQRCPCQ--------NGGVCHHVTGEC-SCPSGWMGTVCG 265
            GA+CE  C  G +G      E   PC           G C  VTGEC  C     G  C 
Sbjct: 825  GAWCER-CADGYYGNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHC- 882

Query: 266  QPCPEGRFG-----KNCSQECQCHNGGT----CDAATGQCHCSPGYTGERCQDECPVGTY 316
            + C +G +G     KNC + C+CH  G+    C   TG C C P  TG++C D+C  G Y
Sbjct: 883  ERCADGFYGDAVTAKNC-RACECHVKGSHSAVCHLETGLCDCKPNVTGQQC-DQCLHGYY 940

Query: 317  GVLCAETCQCVNGGKCYHVS------GACLCEAGFAGERCEARLCPEGLYGIKCDKRCPC 370
            G+     C+  N      VS      G C C  G AG+RC+   C  G Y  +     PC
Sbjct: 941  GLDSGHGCRPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRCDR--CAHGFYAYQDGSCTPC 998

Query: 371  HLENT-HSCHPMSGECACKPGWSGLYCNETCSPGFYG---EACQQICSC----QNGADCD 422
               +T ++C P +GEC C P   G+ C E C  G +G   E   Q C+C         CD
Sbjct: 999  DCPHTQNTCDPETGECVCPPHTQGVKCEE-CEDGHWGYDAEVGCQACNCSLVGSTHHRCD 1057

Query: 423  SVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDC 482
             VTG C C   F G  C            CS   G ++   C P              DC
Sbjct: 1058 VVTGHCQCKSKFGGRACD----------QCS--LGYRDFPDCVP-------------CDC 1092

Query: 483  SIRCPSGTWGFGCNLTCQCLNGGACNTLD--GTCTCAPGWRGEKCELPCQDGTYGLNCAE 540
             +R   GT G  CN     L  G C  ++  G C C     G +C   C++GT+ L    
Sbjct: 1093 DLR---GTSGDACN-----LEQGLCGCVEETGACPCKENVFGPQCN-ECREGTFALRADN 1143

Query: 541  RCDCS 545
               CS
Sbjct: 1144 PLGCS 1148



 Score =  152 bits (383), Expect = 2e-36
 Identities = 143/479 (29%), Positives = 183/479 (38%), Gaps = 105/479 (21%)

Query: 339  CLCEAGFAGERCEARLCPEGLY---GIKCDKRC-PCHLENTHSCHPMSGEC-------AC 387
            C C  G+ G  CE+  C  G Y   GI     C PC       CH  + EC       AC
Sbjct: 709  CECPQGYTGTSCES--CLSGYYRVDGILFGGICQPCE------CHGHAAECNVHGVCIAC 760

Query: 388  KPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGT 447
                +G++C E C PGFYGE      S     DC        CA           CPL  
Sbjct: 761  AHNTTGVHC-EQCLPGFYGEP-----SRGTPGDCQP------CA-----------CPLTI 797

Query: 448  YGINCSSRCGCKN--DAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGF------GCNLTC 499
               N S  C   +  + VC        C  G+ G  C  RC  G +G        C + C
Sbjct: 798  ASNNFSPTCHLNDGDEVVCD------WCAPGYSGAWCE-RCADGYYGNPTVPGESC-VPC 849

Query: 500  QCLNG------GACNTLDGTCT-CAPGWRGEKCELPCQDGTYG-----LNCAERCDC--- 544
             C         G C+++ G C  C     G  CE  C DG YG      NC   C+C   
Sbjct: 850  DCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHCER-CADGFYGDAVTAKNC-RACECHVK 907

Query: 545  -SHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCS---LPCYCKNGASCSP---DD 597
             SH+  CH  TG C C P  +G  CD  C  G +G +      PC C    S S    D+
Sbjct: 908  GSHSAVCHLETGLCDCKPNVTGQQCDQ-CLHGYYGLDSGHGCRPCNCSVAGSVSDGCTDE 966

Query: 598  GICECAPGFRGTTCQRICSPGFYGHRCSQTCP-QCVHSSGPCHHITGLCDCLPGFTGALC 656
            G C C PG  G  C R C+ GFY ++     P  C H+   C   TG C C P   G  C
Sbjct: 967  GQCHCVPGVAGKRCDR-CAHGFYAYQDGSCTPCDCPHTQNTCDPETGECVCPPHTQGVKC 1025

Query: 657  NEVCPSGRFGKNC---AGICTCTNNGT----CNPIDRSCQCYPGWIGSDCSQPCPPAHWG 709
             E C  G +G +       C C+  G+    C+ +   CQC   + G  C Q        
Sbjct: 1026 EE-CEDGHWGYDAEVGCQACNCSLVGSTHHRCDVVTGHCQCKSKFGGRACDQCSLGYRDF 1084

Query: 710  PNCIHTCNCH----NGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNG 764
            P+C+  C+C     +G  C+   G C C        C +      +G  C    +C+ G
Sbjct: 1085 PDCV-PCDCDLRGTSGDACNLEQGLCGCVEETGACPCKE----NVFGPQCN---ECREG 1135



 Score =  151 bits (381), Expect = 4e-36
 Identities = 131/452 (28%), Positives = 166/452 (36%), Gaps = 87/452 (19%)

Query: 94   CCPGFYES-----GEMCVP-----HCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDG-- 141
            C  G+Y       G +C P     H A+  VHG CIA     C     G +C     G  
Sbjct: 723  CLSGYYRVDGILFGGICQPCECHGHAAECNVHGVCIA-----CAHNTTGVHCEQCLPGFY 777

Query: 142  ---DHWGPHCTSRCQCKNGALCNPITGACH-----------CAAGFRGWRCEDRCEQGTY 187
                   P     C C      N  +  CH           CA G+ G  CE RC  G Y
Sbjct: 778  GEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYSGAWCE-RCADGYY 836

Query: 188  GN-----------DCHQRCQCQNGATCDHVTGEC-RCPPGYTGAFCEDLCPPGKHGP--- 232
            GN           DC           CD VTGEC +C     GA CE  C  G +G    
Sbjct: 837  GNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHCE-RCADGFYGDAVT 895

Query: 233  -----QCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHN-- 285
                  CE      +  VCH  TG C C     G  C Q C  G +G +    C+  N  
Sbjct: 896  AKNCRACECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQ-CLHGYYGLDSGHGCRPCNCS 954

Query: 286  --GGTCDAAT--GQCHCSPGYTGERCQDECPVGTYGVL--CAETCQCVN-GGKCYHVSGA 338
              G   D  T  GQCHC PG  G+RC D C  G Y         C C +    C   +G 
Sbjct: 955  VAGSVSDGCTDEGQCHCVPGVAGKRC-DRCAHGFYAYQDGSCTPCDCPHTQNTCDPETGE 1013

Query: 339  CLCEAGFAGERCEARLCPEGLYGIKCD---KRCPCHLENT--HSCHPMSGECACKPGWSG 393
            C+C     G +CE   C +G +G   +   + C C L  +  H C  ++G C CK  + G
Sbjct: 1014 CVCPPHTQGVKCEE--CEDGHWGYDAEVGCQACNCSLVGSTHHRCDVVTGHCQCKSKFGG 1071

Query: 394  LYCNETCSPGFYGEACQQICSC-------------QNGADCDSVTGKCTCAPGFKGIDCS 440
              C++ CS G+        C C             Q    C   TG C C     G  C+
Sbjct: 1072 RACDQ-CSLGYRDFPDCVPCDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGPQCN 1130

Query: 441  TPCPLGTYGINCSSRCGCKNDAVCSPVDGSCT 472
              C  GT+ +   +  GC +   CS +   C+
Sbjct: 1131 -ECREGTFALRADNPLGC-SPCFCSGLSHLCS 1160



 Score =  147 bits (370), Expect = 7e-35
 Identities = 121/380 (31%), Positives = 163/380 (42%), Gaps = 69/380 (18%)

Query: 514  CTCAPGWRGEKCELPCQDGTYGLN------CAERCDC-SHADGCHPTTGHCRCLPGWSGV 566
            C C  G+ G  CE  C  G Y ++        + C+C  HA  C+       C    +GV
Sbjct: 709  CECPQGYTGTSCE-SCLSGYYRVDGILFGGICQPCECHGHAAECNVHGVCIACAHNTTGV 767

Query: 567  HCDSVCAEGRWG------PNCSLPCYC-------KNGASCSPDDG---ICE-CAPGFRGT 609
            HC+  C  G +G      P    PC C           +C  +DG   +C+ CAPG+ G 
Sbjct: 768  HCEQ-CLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYSGA 826

Query: 610  TCQRICSPGFYGHRC--SQTCPQCVHS-------SGPCHHITGLC-DCLPGFTGALCNEV 659
             C+R C+ G+YG+     ++C  C  S       +G C  +TG C  CL    GA C E 
Sbjct: 827  WCER-CADGYYGNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHC-ER 884

Query: 660  CPSGRFG-----KNCAGICTC----TNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGP 710
            C  G +G     KNC   C C    +++  C+     C C P   G  C Q C   ++G 
Sbjct: 885  CADGFYGDAVTAKNCRA-CECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQ-CLHGYYGL 942

Query: 711  NCIH---TCNCHNGAFCS---AYDGECKCTPGWTGLYCTQRCPLGFYGKD--CALICQCQ 762
            +  H    CNC      S     +G+C C PG  G  C  RC  GFY         C C 
Sbjct: 943  DSGHGCRPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRC-DRCAHGFYAYQDGSCTPCDCP 1001

Query: 763  NGAD-CDHISGQCTCRTGFMGRHCEQKCPSGTYGY----GCRQICDC-LNNST---CDHI 813
            +  + CD  +G+C C     G  CE+ C  G +GY    GC Q C+C L  ST   CD +
Sbjct: 1002 HTQNTCDPETGECVCPPHTQGVKCEE-CEDGHWGYDAEVGC-QACNCSLVGSTHHRCDVV 1059

Query: 814  TGTCYCSPGWKGARCDQAGV 833
            TG C C   + G  CDQ  +
Sbjct: 1060 TGHCQCKSKFGGRACDQCSL 1079



 Score =  139 bits (349), Expect = 2e-32
 Identities = 130/462 (28%), Positives = 179/462 (38%), Gaps = 98/462 (21%)

Query: 428  CTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCP 487
            C C  G+ G  C + C  G Y ++     G     +C P      C+   H  +C++   
Sbjct: 709  CECPQGYTGTSCES-CLSGYYRVD-----GILFGGICQP------CECHGHAAECNVH-- 754

Query: 488  SGTWGFGCNLTCQCLNGGACNTLDGTCT-CAPGWRGEKCELPCQDGTYGLNCAERCDC-- 544
                  G  + C      A NT    C  C PG+ GE        GT G +C + C C  
Sbjct: 755  ------GVCIAC------AHNTTGVHCEQCLPGFYGEPSR-----GTPG-DC-QPCACPL 795

Query: 545  -----SHADGCHPTTGH---CR-CLPGWSGVHCDSVCAEGRWGP-----NCSLPCYCKNG 590
                 + +  CH   G    C  C PG+SG  C+  CA+G +G         +PC C   
Sbjct: 796  TIASNNFSPTCHLNDGDEVVCDWCAPGYSGAWCER-CADGYYGNPTVPGESCVPCDCSGN 854

Query: 591  AS------CSPDDGIC-ECAPGFRGTTCQRICSPGFYGHRCS-QTCPQC-VHSSGP---- 637
                    C    G C +C     G  C+R C+ GFYG   + + C  C  H  G     
Sbjct: 855  VDPSEAGHCDSVTGECLKCLGNTDGAHCER-CADGFYGDAVTAKNCRACECHVKGSHSAV 913

Query: 638  CHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPI------DRSCQCY 691
            CH  TGLCDC P  TG  C++ C  G +G +    C   N      +      +  C C 
Sbjct: 914  CHLETGLCDCKPNVTGQQCDQ-CLHGYYGLDSGHGCRPCNCSVAGSVSDGCTDEGQCHCV 972

Query: 692  PGWIGSDCSQPCPP--AHWGPNCIHTCNC-HNGAFCSAYDGECKCTPGWTGLYCTQRCPL 748
            PG  G  C +      A+   +C   C+C H    C    GEC C P   G+ C + C  
Sbjct: 973  PGVAGKRCDRCAHGFYAYQDGSCT-PCDCPHTQNTCDPETGECVCPPHTQGVKC-EECED 1030

Query: 749  GFYGKDCALICQCQNGA-------DCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQI 801
            G +G D  + CQ  N +        CD ++G C C++ F GR C+Q C  G   +     
Sbjct: 1031 GHWGYDAEVGCQACNCSLVGSTHHRCDVVTGHCQCKSKFGGRACDQ-CSLGYRDFPDCVP 1089

Query: 802  CDCLNNST-------------CDHITGTCYCSPGWKGARCDQ 830
            CDC    T             C   TG C C     G +C++
Sbjct: 1090 CDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGPQCNE 1131



 Score =  134 bits (338), Expect = 4e-31
 Identities = 107/329 (32%), Positives = 143/329 (43%), Gaps = 63/329 (19%)

Query: 556  HCRCLPGWSGVHCDSVCAEGRW-------GPNCSLPCYCKNGASCSPDDGIC-ECAPGFR 607
            HC C  G++G  C+S C  G +       G  C  PC C   A+     G+C  CA    
Sbjct: 708  HCECPQGYTGTSCES-CLSGYYRVDGILFGGICQ-PCECHGHAAECNVHGVCIACAHNTT 765

Query: 608  GTTCQRICSPGFYGHRCSQT--------CPQCVHS---SGPCHHITG---LCD-CLPGFT 652
            G  C++ C PGFYG     T        CP  + S   S  CH   G   +CD C PG++
Sbjct: 766  GVHCEQ-CLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYS 824

Query: 653  GALCNEVCPSGRF------GKNCAGICTCTNN------GTCNPIDRSC-QCYPGWIGSDC 699
            GA C E C  G +      G++C   C C+ N      G C+ +   C +C     G+ C
Sbjct: 825  GAWC-ERCADGYYGNPTVPGESCVP-CDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHC 882

Query: 700  SQPCPPAHWG-----PNCIHTCNCH----NGAFCSAYDGECKCTPGWTGLYCTQRCPLGF 750
             + C    +G      NC   C CH    + A C    G C C P  TG  C Q C  G+
Sbjct: 883  ER-CADGFYGDAVTAKNC-RACECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQ-CLHGY 939

Query: 751  YGKDCALICQCQNGADCDHIS------GQCTCRTGFMGRHCEQKCPSGTYGY--GCRQIC 802
            YG D    C+  N +    +S      GQC C  G  G+ C+ +C  G Y Y  G    C
Sbjct: 940  YGLDSGHGCRPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRCD-RCAHGFYAYQDGSCTPC 998

Query: 803  DCLN-NSTCDHITGTCYCSPGWKGARCDQ 830
            DC +  +TCD  TG C C P  +G +C++
Sbjct: 999  DCPHTQNTCDPETGECVCPPHTQGVKCEE 1027



 Score =  130 bits (327), Expect = 7e-30
 Identities = 114/399 (28%), Positives = 145/399 (36%), Gaps = 71/399 (17%)

Query: 93   QCCPGFYESGEMCVPHCADKCVHGRCIAPN----TCQ-----------CEPGWGGTNCSS 137
            QC PGFY       P     C     IA N    TC            C PG+ G  C  
Sbjct: 771  QCLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYSGAWCER 830

Query: 138  ACDGDHWGP----------HCTSRCQCKNGALCNPITGAC-HCAAGFRGWRCEDRCEQGT 186
              DG +  P           C+          C+ +TG C  C     G  CE RC  G 
Sbjct: 831  CADGYYGNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHCE-RCADGF 889

Query: 187  YGN-----DCHQRCQC----QNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQR 237
            YG+     +C + C+C     + A C   TG C C P  TG  C D C  G +G      
Sbjct: 890  YGDAVTAKNC-RACECHVKGSHSAVCHLETGLCDCKPNVTGQQC-DQCLHGYYGLDSGHG 947

Query: 238  C-PCQ---NGGVCHHVT--GECSCPSGWMGTVCGQPCPEG--RFGKNCSQECQC-HNGGT 288
            C PC     G V    T  G+C C  G  G  C + C  G   +       C C H   T
Sbjct: 948  CRPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRCDR-CAHGFYAYQDGSCTPCDCPHTQNT 1006

Query: 289  CDAATGQCHCSPGYTGERCQDECPVGTYGV---LCAETCQCVNGGKCYH----VSGACLC 341
            CD  TG+C C P   G +C +EC  G +G    +  + C C   G  +H    V+G C C
Sbjct: 1007 CDPETGECVCPPHTQGVKC-EECEDGHWGYDAEVGCQACNCSLVGSTHHRCDVVTGHCQC 1065

Query: 342  EAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTH-----------SCHPMSGECACKPG 390
            ++ F G  C+   C  G         C C L  T             C   +G C CK  
Sbjct: 1066 KSKFGGRACDQ--CSLGYRDFPDCVPCDCDLRGTSGDACNLEQGLCGCVEETGACPCKEN 1123

Query: 391  WSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCT 429
              G  CNE C  G +         C +   C  ++  C+
Sbjct: 1124 VFGPQCNE-CREGTFALRADNPLGC-SPCFCSGLSHLCS 1160



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 57/185 (30%), Positives = 74/185 (40%), Gaps = 45/185 (24%)

Query: 687  SCQCYPGWIGSDCSQPCPPAHWGP--------------NCIHTCNCHNGA-FCSAYDGEC 731
            +C C PG +G  C    P  H G                C+  C+C+N +  C    G+C
Sbjct: 1361 NCVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCV-PCSCNNHSDTCDPNTGKC 1419

Query: 732  -KCTPGWTGLYCTQRCPLGFYGK------DCALICQCQNGADC----------DHISGQC 774
              C     G +C   C  G+YGK      DCAL C C +              DH     
Sbjct: 1420 LNCGDNTAGDHCDV-CTSGYYGKVTGSASDCAL-CACPHSPPASFSPTCVLEGDHDFRCD 1477

Query: 775  TCRTGFMGRHCEQKCPSGTYGY-----GCRQICDCLNNST----CDHITGTCYCSPGWKG 825
             C  G+ G+HCE +C S  YG      G  Q CDC  + +    CD  +G C C  G  G
Sbjct: 1478 ACLLGYEGKHCE-RCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASG 1536

Query: 826  ARCDQ 830
             RCD+
Sbjct: 1537 LRCDE 1541



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 65/202 (32%), Positives = 84/202 (41%), Gaps = 47/202 (23%)

Query: 486  CPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNC-AERCDC 544
            CP GT GF C                    CAPG+   K       G   L      C C
Sbjct: 1364 CPPGTVGFSCQ------------------DCAPGYHRGKLPAGSDRGPRPLVAPCVPCSC 1405

Query: 545  S-HADGCHPTTGHC-RCLPGWSGVHCDSVCAEGRWGP------NCSLPCYCKNG--ASCS 594
            + H+D C P TG C  C    +G HCD VC  G +G       +C+L C C +   AS S
Sbjct: 1406 NNHSDTCDPNTGKCLNCGDNTAGDHCD-VCTSGYYGKVTGSASDCAL-CACPHSPPASFS 1463

Query: 595  PD-------DGICE-CAPGFRGTTCQRICSPGFYGHRCSQ--TCPQC---VHSS--GPCH 639
            P        D  C+ C  G+ G  C+R CS  +YG+  +   +C +C    H S  G C 
Sbjct: 1464 PTCVLEGDHDFRCDACLLGYEGKHCER-CSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCD 1522

Query: 640  HITGLCDCLPGFTGALCNEVCP 661
              +G C C  G +G  C+E  P
Sbjct: 1523 RTSGQCVCRLGASGLRCDECEP 1544



 Score = 70.5 bits (171), Expect = 9e-12
 Identities = 69/264 (26%), Positives = 93/264 (35%), Gaps = 82/264 (31%)

Query: 210  CRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCP 269
            C CPPG  G  C+D C PG H                    G+    S         PC 
Sbjct: 1362 CVCPPGTVGFSCQD-CAPGYH-------------------RGKLPAGSDRGPRPLVAPCV 1401

Query: 270  EGRFGKNCSQECQCHN-GGTCDAATGQC-HCSPGYTGERCQDECPVGTYGVLCAETCQCV 327
                       C C+N   TCD  TG+C +C     G+ C D C  G YG +      C 
Sbjct: 1402 P----------CSCNNHSDTCDPNTGKCLNCGDNTAGDHC-DVCTSGYYGKVTGSASDCA 1450

Query: 328  NGGKCYHVSGACLCEAGFAGERCEARLCP-EGLYGIKCDKRCPCHLENTHSCHPMSGECA 386
                        LC    +     +  C  EG +  +CD                    A
Sbjct: 1451 ------------LCACPHSPPASFSPTCVLEGDHDFRCD--------------------A 1478

Query: 387  CKPGWSGLYCNETCSPGFYGE------ACQQICSCQ-NGA---DCDSVTGKCTCAPGFKG 436
            C  G+ G +C E CS  +YG       +CQ+ C C  +G+   DCD  +G+C C  G  G
Sbjct: 1479 CLLGYEGKHC-ERCSSSYYGNPQTPGGSCQK-CDCNPHGSVHGDCDRTSGQCVCRLGASG 1536

Query: 437  IDCSTPCP----LGTYGINCSSRC 456
            + C    P    + T  ++C   C
Sbjct: 1537 LRCDECEPRHILMETDCVSCDDEC 1560



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 59/212 (27%), Positives = 79/212 (37%), Gaps = 56/212 (26%)

Query: 600  CECAPGFRGTTCQRICSPGFYGHRC---SQTCPQ----------CVHSSGPCHHITGLC- 645
            C C PG  G +CQ  C+PG++  +    S   P+          C + S  C   TG C 
Sbjct: 1362 CVCPPGTVGFSCQD-CAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGKCL 1420

Query: 646  DCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPP 705
            +C     G  C +VC SG +GK       C            C C             PP
Sbjct: 1421 NCGDNTAGDHC-DVCTSGYYGKVTGSASDCA----------LCAC----------PHSPP 1459

Query: 706  AHWGPNCIHTCNCHNGAFCSAYDGECK-CTPGWTGLYCTQRCPLGFYGKDCALICQCQN- 763
            A + P C+   +         +D  C  C  G+ G +C +RC   +YG        CQ  
Sbjct: 1460 ASFSPTCVLEGD---------HDFRCDACLLGYEGKHC-ERCSSSYYGNPQTPGGSCQKC 1509

Query: 764  --------GADCDHISGQCTCRTGFMGRHCEQ 787
                      DCD  SGQC CR G  G  C++
Sbjct: 1510 DCNPHGSVHGDCDRTSGQCVCRLGASGLRCDE 1541



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 70/274 (25%), Positives = 98/274 (35%), Gaps = 59/274 (21%)

Query: 102 GEMCVPHC-ADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDH---WGPHCTSRCQCKNG 157
           G MC+ +  A  C          CQCE    G +C+  C G H   W P   S     +G
Sbjct: 267 GGMCICYGHASSCPWDETTKKLQCQCEHNTCGESCNRCCPGYHQQPWRPGTVS-----SG 321

Query: 158 ALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGEC-RCPPGY 216
             C     AC+C          ++ +   Y     ++ +  N A      G C  C    
Sbjct: 322 NTCE----ACNC---------HNKAKDCYYDESVAKQKKSLNTAGQFRGGGVCINCLQNT 368

Query: 217 TGAFCEDLCP----PGKHGPQCEQRCPCQNGGVCHHVTGECSC-PSGWMGTVCGQPCPEG 271
            G  CE        P K  P  ++  PC+           C+C P G + +VC +     
Sbjct: 369 MGINCETCIDGYYRPHKVSPYEDE--PCR----------PCNCDPVGSLSSVCIKD---- 412

Query: 272 RFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQC--VNG 329
                       HNG       GQC C  GYTGE+C D C +G        +C C  V  
Sbjct: 413 ------DLHSDLHNG----KQPGQCPCKEGYTGEKC-DRCQLGYKDYPTCVSCGCNPVGS 461

Query: 330 GKCYHVSGACLCEAGFAGERCEARLCPEGLYGIK 363
                 +G C+C+    G+ C+   C  G Y +K
Sbjct: 462 ASDEPCTGPCVCKENVEGKACDR--CKPGFYNLK 493



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 59/205 (28%), Positives = 72/205 (35%), Gaps = 41/205 (20%)

Query: 124  CQCEPGWGGTNCSSACDGDHWG--PHCTSR-----------CQCKNGA-LCNPITGAC-H 168
            C C PG  G +C     G H G  P  + R           C C N +  C+P TG C +
Sbjct: 1362 CVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGKCLN 1421

Query: 169  CAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPG 228
            C     G  C D C  G YG        C            C CP     +F       G
Sbjct: 1422 CGDNTAGDHC-DVCTSGYYGKVTGSASDC----------ALCACPHSPPASFSPTCVLEG 1470

Query: 229  KHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNG-- 286
             H  +C+       G  C        C S +     G P   G   + C  +C  H    
Sbjct: 1471 DHDFRCDACLLGYEGKHCER------CSSSYY----GNPQTPGGSCQKC--DCNPHGSVH 1518

Query: 287  GTCDAATGQCHCSPGYTGERCQDEC 311
            G CD  +GQC C  G +G RC DEC
Sbjct: 1519 GDCDRTSGQCVCRLGASGLRC-DEC 1542



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 61/216 (28%), Positives = 76/216 (35%), Gaps = 68/216 (31%)

Query: 385  CACKPGWSGLYCNETCSPGFYGEACQQ--------------ICSCQNGAD-CDSVTGKC- 428
            C C PG  G  C + C+PG++                     CSC N +D CD  TGKC 
Sbjct: 1362 CVCPPGTVGFSCQD-CAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGKCL 1420

Query: 429  TCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCS-----PVDGSCTCKAGWHGVDCS 483
             C     G  C   C  G YG    S   C   A+C+     P   S TC          
Sbjct: 1421 NCGDNTAGDHCDV-CTSGYYGKVTGSASDC---ALCACPHSPPASFSPTCVL-------- 1468

Query: 484  IRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGL-----NC 538
                 G   F C+                   C  G+ G+ CE  C    YG        
Sbjct: 1469 ----EGDHDFRCD------------------ACLLGYEGKHCER-CSSSYYGNPQTPGGS 1505

Query: 539  AERCDCS-----HADGCHPTTGHCRCLPGWSGVHCD 569
             ++CDC+     H D C  T+G C C  G SG+ CD
Sbjct: 1506 CQKCDCNPHGSVHGD-CDRTSGQCVCRLGASGLRCD 1540



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 69/258 (26%), Positives = 96/258 (37%), Gaps = 34/258 (13%)

Query: 209 ECRCPPGYTGAFCEDLCP--------PG--KHGPQCEQRCPCQNGGVCHHVTGECSCPSG 258
           +C+C     G  C   CP        PG    G  CE  C C N     +     +    
Sbjct: 289 QCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSGNTCEA-CNCHNKAKDCYYDESVAKQKK 347

Query: 259 WMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQD-EC-PVGTY 316
            + T  GQ    G    NC Q     N  TC     + H    Y  E C+   C PVG+ 
Sbjct: 348 SLNTA-GQ-FRGGGVCINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNCDPVGSL 405

Query: 317 GVLCA--ETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLEN 374
             +C   +    ++ GK     G C C+ G+ GE+C+   C  G         C C+   
Sbjct: 406 SSVCIKDDLHSDLHNGK---QPGQCPCKEGYTGEKCDR--CQLGYKDYPTCVSCGCNPVG 460

Query: 375 THSCHPMSGECACKPGWSGLYCNETCSPGFYG------EACQQICSCQNGAD-CDSVT-- 425
           + S  P +G C CK    G  C + C PGFY         C + C C   +D C S++  
Sbjct: 461 SASDEPCTGPCVCKENVEGKAC-DRCKPGFYNLKEKNPRGCSE-CFCFGVSDVCSSLSWP 518

Query: 426 -GKCTCAPGFKGIDCSTP 442
            G+     G+   D  +P
Sbjct: 519 VGQVNSMSGWLVTDLISP 536



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 66/272 (24%), Positives = 96/272 (35%), Gaps = 46/272 (16%)

Query: 585 CYCKNGASCSPDDGI-----CECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCH 639
           C C   AS  P D       C+C     G +C R C PG++        P  V S   C 
Sbjct: 270 CICYGHASSCPWDETTKKLQCQCEHNTCGESCNRCC-PGYHQQPWR---PGTVSSGNTCE 325

Query: 640 HITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTC-----NPIDRSCQ-CYPG 693
                C+C         +E     +   N AG       G C     N +  +C+ C  G
Sbjct: 326 ----ACNCHNKAKDCYYDESVAKQKKSLNTAG--QFRGGGVCINCLQNTMGINCETCIDG 379

Query: 694 W-----IGSDCSQPCPPAHWGPNCIHTCNC-----HNGAFCSAYDGECKCTPGWTGLYCT 743
           +     +     +PC P +  P    +  C     H+        G+C C  G+TG  C 
Sbjct: 380 YYRPHKVSPYEDEPCRPCNCDPVGSLSSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKC- 438

Query: 744 QRCPLGFYGKDCALICQCQ--NGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGY----- 796
            RC LG+      + C C     A  +  +G C C+    G+ C+ +C  G Y       
Sbjct: 439 DRCQLGYKDYPTCVSCGCNPVGSASDEPCTGPCVCKENVEGKACD-RCKPGFYNLKEKNP 497

Query: 797 -GCRQICDCLN-NSTCDHIT---GTCYCSPGW 823
            GC + C C   +  C  ++   G      GW
Sbjct: 498 RGCSE-CFCFGVSDVCSSLSWPVGQVNSMSGW 528



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 74/297 (24%), Positives = 97/297 (32%), Gaps = 102/297 (34%)

Query: 384 ECACKPGWSGLYCNETCSPGFY-----------GEACQQICSCQNGA-DC---DSVTGK- 427
           +C C+    G  CN  C PG++           G  C+  C+C N A DC   +SV  + 
Sbjct: 289 QCQCEHNTCGESCNRCC-PGYHQQPWRPGTVSSGNTCEA-CNCHNKAKDCYYDESVAKQK 346

Query: 428 --CTCAPGFKGIDCSTPCPLGTYGINCSS---------RCGCKNDAVCSPVDGSCTCKAG 476
                A  F+G      C   T GINC +         +     D  C P    C C   
Sbjct: 347 KSLNTAGQFRGGGVCINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRP----CNCD-- 400

Query: 477 WHGVDCSIRCPSGTWGFGC---NLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGT 533
                     P G+    C   +L     NG       G C C  G+ GEKC+       
Sbjct: 401 ----------PVGSLSSVCIKDDLHSDLHNGKQ----PGQCPCKEGYTGEKCD------- 439

Query: 534 YGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASC 593
                  RC   + D  +PT   C C P  S                          AS 
Sbjct: 440 -------RCQLGYKD--YPTCVSCGCNPVGS--------------------------ASD 464

Query: 594 SPDDGICECAPGFRGTTCQRICSPGFYG--HRCSQTCPQCVHSSGPCHHITGLCDCL 648
            P  G C C     G  C R C PGFY    +  + C +C      C  ++ +C  L
Sbjct: 465 EPCTGPCVCKENVEGKACDR-CKPGFYNLKEKNPRGCSECF-----CFGVSDVCSSL 515



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 40/132 (30%), Positives = 55/132 (41%), Gaps = 26/132 (19%)

Query: 731 CKCTPGWTGLYCTQRCPLGFYGKDCALI------CQCQNGADCDHISGQC-TCRTGFMGR 783
           C+C  G+TG  C + C  G+Y  D  L       C+C   A   ++ G C  C     G 
Sbjct: 709 CECPQGYTGTSC-ESCLSGYYRVDGILFGGICQPCECHGHAAECNVHGVCIACAHNTTGV 767

Query: 784 HCEQKCPSGTYGYGCR------QICDCLNNSTCDHITGTCY-----------CSPGWKGA 826
           HCEQ C  G YG   R      Q C C      ++ + TC+           C+PG+ GA
Sbjct: 768 HCEQ-CLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYSGA 826

Query: 827 RCDQAGVIIVGN 838
            C++      GN
Sbjct: 827 WCERCADGYYGN 838



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 44/157 (28%), Positives = 56/157 (35%), Gaps = 46/157 (29%)

Query: 105  CVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCK-NGALCNPI 163
            CVP   +   H     PNT +C       NC     GDH    CTS    K  G+  +  
Sbjct: 1400 CVPCSCNN--HSDTCDPNTGKC------LNCGDNTAGDHCDV-CTSGYYGKVTGSASDCA 1450

Query: 164  TGACH-----------------------CAAGFRGWRCEDRCEQGTYGN------DCHQR 194
              AC                        C  G+ G  CE RC    YGN       C Q+
Sbjct: 1451 LCACPHSPPASFSPTCVLEGDHDFRCDACLLGYEGKHCE-RCSSSYYGNPQTPGGSC-QK 1508

Query: 195  CQCQNGAT----CDHVTGECRCPPGYTGAFCEDLCPP 227
            C C    +    CD  +G+C C  G +G  C++ C P
Sbjct: 1509 CDCNPHGSVHGDCDRTSGQCVCRLGASGLRCDE-CEP 1544


>gi|119703755 laminin, beta 2 precursor [Homo sapiens]
          Length = 1798

 Score =  172 bits (436), Expect = 2e-42
 Identities = 143/424 (33%), Positives = 167/424 (39%), Gaps = 90/424 (21%)

Query: 238  CPCQNGGV----CHHVTGECSCPSGWMGTVCGQPCPEGR--FGKNCSQECQCHNGGT--- 288
            C C   G     C+   G+C C  G +G  C   C  G   FG    Q CQC + G    
Sbjct: 783  CQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDL-CAPGYYGFGPTGCQACQCSHEGALSS 841

Query: 289  -CDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNG--GKCYHVSGACL-CEAG 344
             C+  +GQC C  G  G RC D C  G +G      C C NG   +C   +GACL C   
Sbjct: 842  LCEKTSGQCLCRTGAFGLRC-DRCQRGQWGFPSCRPCVC-NGHADECNTHTGACLGCRDH 899

Query: 345  FAGERCEARLC-----PEGLYGIKCDKRCPC------HLENTHSCHPMSGE----CACKP 389
              GE CE  +      P   YG +C + CPC            SCH         C C+ 
Sbjct: 900  TGGEHCERCIAGFHGDPRLPYGGQC-RPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRA 958

Query: 390  GWSGLYCNETCSPGFYGEACQ-----QICSCQNGAD------CDSVTGKCT--------- 429
            G++GL C E C+PG +G+  +     Q+C C    D      CD  TG+C          
Sbjct: 959  GYTGLRC-EACAPGHFGDPSRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGP 1017

Query: 430  ----CAPGFKGIDCSTPCP------LGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHG 479
                C PGF G      C       LGT    C S   C     C P  G C C     G
Sbjct: 1018 HCAHCKPGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCH----CDPSSGQCPCLPNVQG 1073

Query: 480  VDCSIRCPSGTW----GFGCNLTCQC----LNGGACNTLDGTCTCAPGWRGEKCELPCQD 531
              C  RC    W    G GC   C C      G  CN   G C C  G+ G  C   CQ+
Sbjct: 1074 PSCD-RCAPNFWNLTSGHGCQ-PCACHPSRARGPTCNEFTGQCHCRAGFGGRTCS-ECQE 1130

Query: 532  ---GTYGLNCAERCDCSH----ADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWG--PNCS 582
               G  GL C   CDC         CH  TGHC C PG SGV CD  CA G  G  P C 
Sbjct: 1131 LHWGDPGLQC-HACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQ-CARGFSGIFPACH 1188

Query: 583  LPCY 586
             PC+
Sbjct: 1189 -PCH 1191



 Score =  165 bits (418), Expect = 2e-40
 Identities = 129/405 (31%), Positives = 158/405 (39%), Gaps = 81/405 (20%)

Query: 497  LTCQCLNGGA----CNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCA--ERCDCSHADG- 549
            L CQC   G+    CN   G C C PG  G +C+L C  G YG      + C CSH    
Sbjct: 781  LPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDL-CAPGYYGFGPTGCQACQCSHEGAL 839

Query: 550  ---CHPTTGHCRCLPGWSGVHCDSVCAEGRWG-PNCSLPCYCKNGAS-CSPDDGIC-ECA 603
               C  T+G C C  G  G+ CD  C  G+WG P+C  PC C   A  C+   G C  C 
Sbjct: 840  SSLCEKTSGQCLCRTGAFGLRCDR-CQRGQWGFPSCR-PCVCNGHADECNTHTGACLGCR 897

Query: 604  PGFRGTTCQRICSPGF-------YGHRCSQTCPQCVHSSGPCHHITG-----------LC 645
                G  C+R C  GF       YG +C + CP C    G   H              +C
Sbjct: 898  DHTGGEHCER-CIAGFHGDPRLPYGGQC-RPCP-CPEGPGSQRHFATSCHQDEYSQQIVC 954

Query: 646  DCLPGFTGALCNEVCPSGRFGKNC-----AGICTCTNN------GTCNPIDRSC-QCYPG 693
             C  G+TG  C E C  G FG          +C C+ N        C+P    C +C   
Sbjct: 955  HCRAGYTGLRC-EACAPGHFGDPSRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHH 1013

Query: 694  WIGSDCSQPCPPAHWGP---NCIHTCNCH------------NGAFCSAYDGECKCTPGWT 738
              G  C+  C P   G       H C C+            +   C    G+C C P   
Sbjct: 1014 TEGPHCAH-CKPGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQ 1072

Query: 739  GLYCTQRCPLGFYG-------KDCALICQCQNGADCDHISGQCTCRTGFMGRHCE--QKC 789
            G  C  RC   F+        + CA       G  C+  +GQC CR GF GR C   Q+ 
Sbjct: 1073 GPSC-DRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCSECQEL 1131

Query: 790  PSGTYGYGCRQICDC----LNNSTCDHITGTCYCSPGWKGARCDQ 830
              G  G  C   CDC    ++   C   TG C C PG  G RCDQ
Sbjct: 1132 HWGDPGLQC-HACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQ 1175



 Score =  150 bits (380), Expect = 5e-36
 Identities = 137/447 (30%), Positives = 181/447 (40%), Gaps = 95/447 (21%)

Query: 93   QCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDH-WGPHCTSR 151
            QC P    S E C PH       G+C+      C+PG  G  C     G + +GP     
Sbjct: 784  QCNPQGSLSSE-CNPH------GGQCL------CKPGVVGRRCDLCAPGYYGFGPTGCQA 830

Query: 152  CQCKN----GALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGA-TCDHV 206
            CQC +     +LC   +G C C  G  G RC DRC++G +G    + C C   A  C+  
Sbjct: 831  CQCSHEGALSSLCEKTSGQCLCRTGAFGLRC-DRCQRGQWGFPSCRPCVCNGHADECNTH 889

Query: 207  TGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQ 266
            TG C     +TG    + C  G HG   + R P   GG C      C CP G        
Sbjct: 890  TGACLGCRDHTGGEHCERCIAGFHG---DPRLP--YGGQCR----PCPCPEG-------- 932

Query: 267  PCPEGRFGKNCSQECQCHNGGTCDAATGQ--CHCSPGYTGERCQDECPVGTYGVLC---- 320
            P  +  F  +C Q          D  + Q  CHC  GYTG RC + C  G +G       
Sbjct: 933  PGSQRHFATSCHQ----------DEYSQQIVCHCRAGYTGLRC-EACAPGHFGDPSRPGG 981

Query: 321  -AETCQC------VNGGKCYHVSGACL-CEAGFAGERCEARLCPEGLYGIKCDK---RCP 369
              + C+C      ++   C   +G CL C     G  C    C  G +G    +   RC 
Sbjct: 982  RCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGPHCAH--CKPGFHGQAARQSCHRCT 1039

Query: 370  CHLENTH----------SCHPMSGECACKPGWSGLYCNETCSPGFY----GEACQQICSC 415
            C+L  T+           C P SG+C C P   G  C + C+P F+    G  CQ  C+C
Sbjct: 1040 CNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSC-DRCAPNFWNLTSGHGCQP-CAC 1097

Query: 416  Q----NGADCDSVTGKCTCAPGFKGIDCSTPCPL--GTYGINCSSRCGCKNDAV----CS 465
                  G  C+  TG+C C  GF G  CS    L  G  G+ C + C C +  +    C 
Sbjct: 1098 HPSRARGPTCNEFTGQCHCRAGFGGRTCSECQELHWGDPGLQCHA-CDCDSRGIDTPQCH 1156

Query: 466  PVDGSCTCKAGWHGVDCSIRCPSGTWG 492
               G C+C+ G  GV C  +C  G  G
Sbjct: 1157 RFTGHCSCRPGVSGVRCD-QCARGFSG 1182



 Score =  114 bits (285), Expect = 5e-25
 Identities = 101/330 (30%), Positives = 125/330 (37%), Gaps = 78/330 (23%)

Query: 104  MCVPHCADKC-VH-GRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCN 161
            +C  H AD+C  H G C+      C    GG +C     G H  P      QC+    C 
Sbjct: 878  VCNGH-ADECNTHTGACLG-----CRDHTGGEHCERCIAGFHGDPRLPYGGQCRP-CPCP 930

Query: 162  PITGA------------------CHCAAGFRGWRCEDRCEQGTYGNDCH-----QRCQCQ 198
               G+                  CHC AG+ G RCE  C  G +G+        Q C+C 
Sbjct: 931  EGPGSQRHFATSCHQDEYSQQIVCHCRAGYTGLRCE-ACAPGHFGDPSRPGGRCQLCECS 989

Query: 199  NGA------TCDHVTGEC-RCPPGYTGAFCEDLCPPGKHGPQCEQ---RCPCQNGGV--- 245
                      CD  TG+C RC     G  C   C PG HG    Q   RC C   G    
Sbjct: 990  GNIDPMDPDACDPHTGQCLRCLHHTEGPHCAH-CKPGFHGQAARQSCHRCTCNLLGTNPQ 1048

Query: 246  ---------CHHVTGECSCPSGWMGTVCGQPCPEG---RFGKNCSQECQCH----NGGTC 289
                     C   +G+C C     G  C +  P       G  C Q C CH     G TC
Sbjct: 1049 QCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGC-QPCACHPSRARGPTC 1107

Query: 290  DAATGQCHCSPGYTGERCQD--ECPVGTYGVLCAETCQCVNGG----KCYHVSGACLCEA 343
            +  TGQCHC  G+ G  C +  E   G  G+ C   C C + G    +C+  +G C C  
Sbjct: 1108 NEFTGQCHCRAGFGGRTCSECQELHWGDPGLQC-HACDCDSRGIDTPQCHRFTGHCSCRP 1166

Query: 344  GFAGERCEARLCPEGLYGI--KCDKRCPCH 371
            G +G RC+   C  G  GI   C    PCH
Sbjct: 1167 GVSGVRCDQ--CARGFSGIFPACH---PCH 1191



 Score =  100 bits (250), Expect = 6e-21
 Identities = 81/274 (29%), Positives = 98/274 (35%), Gaps = 55/274 (20%)

Query: 93   QCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGP------ 146
            QC P     G     H A  C          C C  G+ G  C  AC   H+G       
Sbjct: 923  QCRPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRAGYTGLRC-EACAPGHFGDPSRPGG 981

Query: 147  -----HCTSRCQCKNGALCNPITGAC-------------HCAAGFRGWRCEDRCEQ---- 184
                  C+      +   C+P TG C             HC  GF G      C +    
Sbjct: 982  RCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGPHCAHCKPGFHGQAARQSCHRCTCN 1041

Query: 185  --GTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPG----KHGPQCEQRC 238
              GT    C    QC     CD  +G+C C P   G  C D C P       G  C Q C
Sbjct: 1042 LLGTNPQQCPSPDQCH----CDPSSGQCPCLPNVQGPSC-DRCAPNFWNLTSGHGC-QPC 1095

Query: 239  PCQ----NGGVCHHVTGECSCPSGWMGTVCGQPCPE---GRFGKNCSQECQCHNGG---- 287
             C      G  C+  TG+C C +G+ G  C + C E   G  G  C   C C + G    
Sbjct: 1096 ACHPSRARGPTCNEFTGQCHCRAGFGGRTCSE-CQELHWGDPGLQC-HACDCDSRGIDTP 1153

Query: 288  TCDAATGQCHCSPGYTGERCQDECPVGTYGVLCA 321
             C   TG C C PG +G RC D+C  G  G+  A
Sbjct: 1154 QCHRFTGHCSCRPGVSGVRC-DQCARGFSGIFPA 1186



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 77/255 (30%), Positives = 99/255 (38%), Gaps = 70/255 (27%)

Query: 335 VSGACLCEAGFAGERCEA----------RLCPEGLYGIKCDKRCPCHLENTHSCH----- 379
           V GAC+C+    G  CE           R   +G +   C ++C CH  +THSCH     
Sbjct: 306 VHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDG-HSHAC-RKCECH-GHTHSCHFDMAV 362

Query: 380 ------PMSGEC-ACKPGWSGLYCNETCSPGFYGEACQQI--------CSC-----QNGA 419
                    G C  C+   +G +C E C P FY +  + +        C C     Q+G 
Sbjct: 363 YLASGNVSGGVCDGCQHNTAGRHC-ELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGG 421

Query: 420 DCDS--------VTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKN----------- 460
            CDS        V+G+C C     G  C   C  G +G++ S R GC+            
Sbjct: 422 RCDSHDDPALGLVSGQCRCKEHVVGTRCQQ-CRDGFFGLSISDRLGCRRCQCNARGTVPG 480

Query: 461 DAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWG-----FGCNLTCQCLNGGA----CNTLD 511
              C P  GSC CK    G  C  RC  G WG      GC   C C  GGA    C+   
Sbjct: 481 STPCDPNSGSCYCKRLVTGRGCD-RCLPGHWGLSHDLLGCR-PCDCDVGGALDPQCDEGT 538

Query: 512 GTCTCAPGWRGEKCE 526
           G C C     G +CE
Sbjct: 539 GQCHCRQHMVGRRCE 553



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 82/292 (28%), Positives = 108/292 (36%), Gaps = 52/292 (17%)

Query: 88  YRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDH---W 144
           Y   S+C P          P  A+  VHG CI      C+    G NC    D      W
Sbjct: 286 YGHASECAPA------PGAPAHAEGMVHGACI------CKHNTRGLNCEQCQDFYRDLPW 333

Query: 145 GP------HCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQ 198
            P      H   +C+C           A + A+G       D C+  T G  C     C+
Sbjct: 334 RPAEDGHSHACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCEL---CR 390

Query: 199 NGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSG 258
                D  T + R P       C+ +      G Q   RC   +      V+G+C C   
Sbjct: 391 PFFYRDP-TKDLRDPAVCRSCDCDPM------GSQDGGRCDSHDDPALGLVSGQCRCKEH 443

Query: 259 WMGTVCGQPCPEGRFGKNCS-----QECQCHNGGT------CDAATGQCHCSPGYTGERC 307
            +GT C Q C +G FG + S     + CQC+  GT      CD  +G C+C    TG  C
Sbjct: 444 VVGTRC-QQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGC 502

Query: 308 QDECPVGTYGV----LCAETCQCVNGG----KCYHVSGACLCEAGFAGERCE 351
            D C  G +G+    L    C C  GG    +C   +G C C     G RCE
Sbjct: 503 -DRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRCE 553



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 74/292 (25%), Positives = 104/292 (35%), Gaps = 66/292 (22%)

Query: 585 CYCKNGAS-CSPDDGI-----------CECAPGFRGTTCQRICS--------PGFYGHRC 624
           C+C   AS C+P  G            C C    RG  C++           P   GH  
Sbjct: 283 CFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSH 342

Query: 625 SQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTC------TNN 678
           +    +C   +  CH    +       +G +C+  C     G++C  +C        T +
Sbjct: 343 ACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDG-CQHNTAGRHCE-LCRPFFYRDPTKD 400

Query: 679 GTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWT 738
                + RSC C P                G      C+ H+        G+C+C     
Sbjct: 401 LRDPAVCRSCDCDP---------------MGSQDGGRCDSHDDPALGLVSGQCRCKEHVV 445

Query: 739 GLYCTQRCPLGFYGKDCA-----LICQCQ------NGADCDHISGQCTCRTGFMGRHCEQ 787
           G  C Q+C  GF+G   +       CQC           CD  SG C C+    GR C+ 
Sbjct: 446 GTRC-QQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCD- 503

Query: 788 KCPSGTYGY-----GCRQICDC----LNNSTCDHITGTCYCSPGWKGARCDQ 830
           +C  G +G      GCR  CDC      +  CD  TG C+C     G RC+Q
Sbjct: 504 RCLPGHWGLSHDLLGCRP-CDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQ 554



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 55/177 (31%), Positives = 68/177 (38%), Gaps = 34/177 (19%)

Query: 92   SQCCPGFYESGEMCVPHCADKCVHG----RCIAPNTCQCEPGWGGTNC--------SSAC 139
            + C PGF+        H     + G    +C +P+ C C+P  G   C           C
Sbjct: 1020 AHCKPGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRC 1079

Query: 140  DGDHWG---PHCTSRCQCK----NGALCNPITGACHCAAGFRGWRCEDRCEQ---GTYGN 189
              + W     H    C C      G  CN  TG CHC AGF G  C + C++   G  G 
Sbjct: 1080 APNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCSE-CQELHWGDPGL 1138

Query: 190  DCHQRCQCQNGA----TCDHVTGECRCPPGYTGAFCEDLCPPGKHG--PQCEQRCPC 240
             CH  C C +       C   TG C C PG +G  C D C  G  G  P C    PC
Sbjct: 1139 QCH-ACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRC-DQCARGFSGIFPACH---PC 1190



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 81/305 (26%), Positives = 99/305 (32%), Gaps = 81/305 (26%)

Query: 512 GTCTCAPGWRGEKCELPCQDGTYGL----------NCAERCDC-SHADGCHPTTGHCRCL 560
           G C C    RG  CE  CQD    L          +   +C+C  H   CH         
Sbjct: 308 GACICKHNTRGLNCE-QCQDFYRDLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLAS 366

Query: 561 PGWSGVHCDSVCAEGRWGPNCSL--PCYCKNGASCSPDDGICECAPGFRGTTCQRICSPG 618
              SG  CD  C     G +C L  P + ++      D  +C      R   C  + S  
Sbjct: 367 GNVSGGVCDG-CQHNTAGRHCELCRPFFYRDPTKDLRDPAVC------RSCDCDPMGSQD 419

Query: 619 FYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNN 678
             G RC        H       ++G C C     G  C + C  G FG + +    C   
Sbjct: 420 --GGRCDS------HDDPALGLVSGQCRCKEHVVGTRCQQ-CRDGFFGLSISDRLGC--- 467

Query: 679 GTCNPIDRSCQC-----YPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKC 733
                  R CQC      PG      S PC P                       G C C
Sbjct: 468 -------RRCQCNARGTVPG------STPCDPN---------------------SGSCYC 493

Query: 734 TPGWTGLYCTQRCPLGFYGKDCALI----CQCQNGA----DCDHISGQCTCRTGFMGRHC 785
               TG  C  RC  G +G    L+    C C  G      CD  +GQC CR   +GR C
Sbjct: 494 KRLVTGRGC-DRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRC 552

Query: 786 EQKCP 790
           EQ  P
Sbjct: 553 EQVQP 557



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 72/285 (25%), Positives = 96/285 (33%), Gaps = 85/285 (29%)

Query: 230 HGPQCEQR--CPCQNGGVCHHVTGECSCPSGWMGTVCGQ-----------PCPEGRFGKN 276
           H  +C      P    G+ H   G C C     G  C Q           P  +G    +
Sbjct: 288 HASECAPAPGAPAHAEGMVH---GACICKHNTRGLNCEQCQDFYRDLPWRPAEDGH--SH 342

Query: 277 CSQECQCHNGGTCDAATGQCH-------CSPGYTGERCQDECPVGTYGVLC--------- 320
             ++C+CH        T  CH        S   +G  C D C   T G  C         
Sbjct: 343 ACRKCECHGH------THSCHFDMAVYLASGNVSGGVC-DGCQHNTAGRHCELCRPFFYR 395

Query: 321 -----------AETCQC-----VNGGKCYH--------VSGACLCEAGFAGERCEARLCP 356
                        +C C      +GG+C          VSG C C+    G RC+   C 
Sbjct: 396 DPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQ--CR 453

Query: 357 EGLYGIKCD-----KRCPCHLENT----HSCHPMSGECACKPGWSGLYCNETCSPGFYGE 407
           +G +G+        +RC C+   T      C P SG C CK   +G  C+  C PG +G 
Sbjct: 454 DGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDR-CLPGHWGL 512

Query: 408 ACQQI----CSCQNGA----DCDSVTGKCTCAPGFKGIDCSTPCP 444
           +   +    C C  G      CD  TG+C C     G  C    P
Sbjct: 513 SHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQP 557


>gi|143770880 laminin, beta 4 [Homo sapiens]
          Length = 1761

 Score =  163 bits (413), Expect = 8e-40
 Identities = 130/398 (32%), Positives = 163/398 (40%), Gaps = 76/398 (19%)

Query: 243  GGVCHHVTGECSCPSGWMGTVCGQPCPEGRF--GKNCSQECQCHNGGT----CDAATGQC 296
            G  C  + G+C C    +G  C + C  G +  G +    C CH  G+    CD  TGQC
Sbjct: 778  GSSCSRLGGQCQCKPLVVGRCCDR-CSTGSYDLGHHGCHPCHCHPQGSKDTVCDQVTGQC 836

Query: 297  HCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGK-CYHVSGACLCEAGFA-GERCEARL 354
             C    +G RC D C  G +G      C C    + C   +G+C    GF  G  CE   
Sbjct: 837  PCHGEVSGRRC-DRCLAGYFGFPSCHPCPCNRFAELCDPETGSCFNCGGFTTGRNCER-- 893

Query: 355  CPEGLYGIKCD----KRCPCHLENT------HSCHPMSGE----CACKPGWSGLYCNETC 400
            C +G YG        + C C  + +      HSC+         C C  G++G  C E C
Sbjct: 894  CIDGYYGNPSSGQPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGE-C 952

Query: 401  SPGFYGE-----ACQQICSCQNGAD------CDSVTGKCT-CAPGFKGIDCSTPCPLGTY 448
            S GFYG      A  Q C+C N  D      C  VTG+C  C    +G +C   C  G Y
Sbjct: 953  STGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLRCLHNTQGANCQL-CKPGHY 1011

Query: 449  GINCSS---RCGCKNDAV-------------CSPVDGSCTCKAGWHGVDCSIRCPSGTW- 491
            G   +    RC C    V             C PV G+C C     G+ C  RC  G W 
Sbjct: 1012 GSALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACD-RCADGYWN 1070

Query: 492  ---GFGCNLTCQC----LNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYG---LNCAER 541
               G GC  +C C         C+ L G C C  G+ G++C   CQ+  YG     C   
Sbjct: 1071 LVPGRGCQ-SCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCS-ECQENYYGDPPGRCIP- 1127

Query: 542  CDCSHADG----CHPTTGHCRCLPGWSGVHCDSVCAEG 575
            CDC+ A      C P TG CRC  G SG  CD  CA G
Sbjct: 1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDR-CARG 1164



 Score =  161 bits (407), Expect = 4e-39
 Identities = 128/393 (32%), Positives = 166/393 (42%), Gaps = 76/393 (19%)

Query: 504  GGACNTLDGTCTCAPGWRGEKCELPCQDGTYGL--NCAERCDCSHADG-----CHPTTGH 556
            G +C+ L G C C P   G  C+  C  G+Y L  +    C C H  G     C   TG 
Sbjct: 778  GSSCSRLGGQCQCKPLVVGRCCDR-CSTGSYDLGHHGCHPCHC-HPQGSKDTVCDQVTGQ 835

Query: 557  CRCLPGWSGVHCDSVCAEGRWG-PNCSLPCYCKNGAS-CSPDDGICECAPGFR-GTTCQR 613
            C C    SG  CD  C  G +G P+C  PC C   A  C P+ G C    GF  G  C+R
Sbjct: 836  CPCHGEVSGRRCDR-CLAGYFGFPSCH-PCPCNRFAELCDPETGSCFNCGGFTTGRNCER 893

Query: 614  ICSPGFYGHRCS-QTCPQCVHSSGP---------CHHITG----LCDCLPGFTGALCNEV 659
             C  G+YG+  S Q C  C+    P         C+        +C+CL G+TG  C E 
Sbjct: 894  -CIDGYYGNPSSGQPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGE- 951

Query: 660  CPSGRFGK-NCAGI----CTCTNN------GTCNPIDRSC-QCYPGWIGSDCSQPCPPAH 707
            C +G +G    +G     C C NN       +C+ +   C +C     G++C Q C P H
Sbjct: 952  CSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLRCLHNTQGANC-QLCKPGH 1010

Query: 708  WGPNCIHTC---NCH-------------NGAFCSAYDGECKCTPGWTGLYCTQRCPLGFY 751
            +G     TC   +CH                 C    G C C P  TGL C  RC  G++
Sbjct: 1011 YGSALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLAC-DRCADGYW 1069

Query: 752  ----GKDCALICQCQ----NGADCDHISGQCTCRTGFMGRHCEQKCPSGTYG--YGCRQI 801
                G+ C   C C       + CD ++GQC C+ G+ G+ C + C    YG   G    
Sbjct: 1070 NLVPGRGCQS-CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSE-CQENYYGDPPGRCIP 1127

Query: 802  CDCLNNST----CDHITGTCYCSPGWKGARCDQ 830
            CDC    T    CD  TG C C  G  G RCD+
Sbjct: 1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDR 1160



 Score =  151 bits (381), Expect = 4e-36
 Identities = 123/407 (30%), Positives = 161/407 (39%), Gaps = 76/407 (18%)

Query: 148  CTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYG------NDCHQRCQCQNGA 201
            C    Q   G+ C+ + G C C     G RC DRC  G+Y       + CH   Q     
Sbjct: 769  CKCHPQGSVGSSCSRLGGQCQCKPLVVG-RCCDRCSTGSYDLGHHGCHPCHCHPQGSKDT 827

Query: 202  TCDHVTGECRCPPGYTGAFCEDLCPPGKHG-PQCEQRCPCQN-GGVCHHVTGEC-SCPSG 258
             CD VTG+C C    +G  C D C  G  G P C   CPC     +C   TG C +C   
Sbjct: 828  VCDQVTGQCPCHGEVSGRRC-DRCLAGYFGFPSCHP-CPCNRFAELCDPETGSCFNCGGF 885

Query: 259  WMGTVCGQPCPEGRFGKNCS----QECQCHNGGTCD------------AATGQCHCSPGY 302
              G  C + C +G +G   S    + C C +  + +            ++   C+C  GY
Sbjct: 886  TTGRNC-ERCIDGYYGNPSSGQPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGY 944

Query: 303  TGERCQDECPVGTYG-----VLCAETCQCVNG------GKCYHVSGACL-CEAGFAGERC 350
            TG +C  EC  G YG         + C C N         C  V+G CL C     G  C
Sbjct: 945  TGTQC-GECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLRCLHNTQGANC 1003

Query: 351  EARLCPEGLYGIKCD---KRCPCHLENTHS-----------CHPMSGECACKPGWSGLYC 396
            +  LC  G YG   +   +RC CH                 C P++G C C P  +GL C
Sbjct: 1004 Q--LCKPGHYGSALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLAC 1061

Query: 397  NETCSPGFY----GEACQQICSC----QNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTY 448
             + C+ G++    G  CQ  C C       + CD +TG+C C  G+ G  CS  C    Y
Sbjct: 1062 -DRCADGYWNLVPGRGCQS-CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCS-ECQENYY 1118

Query: 449  G------INCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSG 489
            G      I C          +C P  G C C+ G  G  C  RC  G
Sbjct: 1119 GDPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCD-RCARG 1164



 Score =  133 bits (334), Expect = 1e-30
 Identities = 113/380 (29%), Positives = 143/380 (37%), Gaps = 73/380 (19%)

Query: 124  CQCEPGWGGTNCSSACDGDH-WGPHCTSRCQC----KNGALCNPITGACHCAAGFRGWRC 178
            CQC+P   G  C     G +  G H    C C        +C+ +TG C C     G RC
Sbjct: 788  CQCKPLVVGRCCDRCSTGSYDLGHHGCHPCHCHPQGSKDTVCDQVTGQCPCHGEVSGRRC 847

Query: 179  EDRCEQGTYGNDCHQRCQCQNGA-TCDHVTGEC-RCPPGYTGAFCEDLCPPGKHG-PQCE 235
             DRC  G +G      C C   A  CD  TG C  C    TG  CE  C  G +G P   
Sbjct: 848  -DRCLAGYFGFPSCHPCPCNRFAELCDPETGSCFNCGGFTTGRNCE-RCIDGYYGNPSSG 905

Query: 236  QRC--------PCQNGGVCHHVTGE-------CSCPSGWMGTVCGQPCPEGRFGK----- 275
            Q C        P  N    H            C+C  G+ GT CG+ C  G +G      
Sbjct: 906  QPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGE-CSTGFYGNPRISG 964

Query: 276  NCSQECQCHNG------GTCDAATGQC-HCSPGYTGERCQDECPVGTYGVLCAETC---- 324
               Q C C+N        +C   TG+C  C     G  CQ  C  G YG    +TC    
Sbjct: 965  APCQPCACNNNIDVTDPESCSRVTGECLRCLHNTQGANCQ-LCKPGHYGSALNQTCRRCS 1023

Query: 325  ---------QCVNGG---KCYHVSGACLCEAGFAGERCEARLCPEGLYGI-------KCD 365
                     +C  GG    C  V+GAC C     G  C+   C +G + +        CD
Sbjct: 1024 CHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDR--CADGYWNLVPGRGCQSCD 1081

Query: 366  KRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQI--CSCQNGAD--- 420
              C      +  C  ++G+C CK G+ G  C+E C   +YG+   +   C C        
Sbjct: 1082 --CDPRTSQSSHCDQLTGQCPCKLGYGGKRCSE-CQENYYGDPPGRCIPCDCNRAGTQKP 1138

Query: 421  -CDSVTGKCTCAPGFKGIDC 439
             CD  TG C C  G  G  C
Sbjct: 1139 ICDPDTGMCRCREGVSGQRC 1158



 Score =  112 bits (280), Expect = 2e-24
 Identities = 101/331 (30%), Positives = 126/331 (38%), Gaps = 71/331 (21%)

Query: 82   HGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWG---GTNCSSA 138
            HGE +  RR  +C  G++     C P   ++        P T  C    G   G NC   
Sbjct: 839  HGEVSG-RRCDRCLAGYF-GFPSCHPCPCNR--FAELCDPETGSCFNCGGFTTGRNCERC 894

Query: 139  CDGDHWGPHCTSRCQ---CKNGALCNPITG------------ACHCAAGFRGWRCEDRCE 183
             DG +  P     C+   C +    N                 C+C  G+ G +C + C 
Sbjct: 895  IDGYYGNPSSGQPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGE-CS 953

Query: 184  QGTYGND------CHQRCQCQNGA------TCDHVTGEC-RCPPGYTGAFCEDLCPPGKH 230
             G YGN       C Q C C N        +C  VTGEC RC     GA C+ LC PG +
Sbjct: 954  TGFYGNPRISGAPC-QPCACNNNIDVTDPESCSRVTGECLRCLHNTQGANCQ-LCKPGHY 1011

Query: 231  GPQCEQ---RCPCQNGGV-------------CHHVTGECSCPSGWMGTVCGQPCPEGRF- 273
            G    Q   RC C   GV             C  VTG C C     G  C + C +G + 
Sbjct: 1012 GSALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDR-CADGYWN 1070

Query: 274  ---GKNCSQECQCH----NGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAE--TC 324
               G+ C Q C C         CD  TGQC C  GY G+RC  EC    YG        C
Sbjct: 1071 LVPGRGC-QSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRC-SECQENYYGDPPGRCIPC 1128

Query: 325  QCVNGGK----CYHVSGACLCEAGFAGERCE 351
             C   G     C   +G C C  G +G+RC+
Sbjct: 1129 DCNRAGTQKPICDPDTGMCRCREGVSGQRCD 1159



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 76/283 (26%), Positives = 95/283 (33%), Gaps = 75/283 (26%)

Query: 92  SQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACD---GDHWGPHC 148
           S+C P     G++  P      VHG+C+      C+    G NC    D      W P  
Sbjct: 272 SECRPMQKMRGDVFSP---PGMVHGQCV------CQHNTDGPNCERCKDFFQDAPWRPAA 322

Query: 149 TSRCQCKNGALCNPITGACH-------CAAGFRGWRCEDRCEQGTYGNDCHQ-------- 193
             +        CN  +  CH        + G  G  CED C+  T G  C +        
Sbjct: 323 DLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCED-CQHNTEGQHCDRCRPLFYRD 381

Query: 194 ------------RCQCQ-----NGATC--------DHVTGECRCPPGYTGAFCEDLCPPG 228
                        C+C      +G  C          V G+C C     GA C D C P 
Sbjct: 382 PLKTISDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKC-DQCKPN 440

Query: 229 KHG-----PQCEQRCPCQNGG-----VCHHVTGECSCPSGWMGTVCGQPCPEGRFG---- 274
            +G     P   Q C C   G      C   TG+C C S   G  C + C  G +G    
Sbjct: 441 HYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHC-EECTVGYWGLGNH 499

Query: 275 -KNCSQECQCHNGGT----CDAATGQCHCSPGYTGERCQDECP 312
              CS  C C  GG     C    GQC C P  TG  C +  P
Sbjct: 500 LHGCSP-CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAP 541



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 71/271 (26%), Positives = 96/271 (35%), Gaps = 60/271 (22%)

Query: 294 GQCHCSPGYTG---ERCQDEC------PVGTYGVLCAETCQC-VNGGKCYHVSGACLCEA 343
           GQC C     G   ERC+D        P          +C C  +  +C+      L   
Sbjct: 293 GQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLASG 352

Query: 344 GFAGERCEARLCPEGLYGIKCDKRCPCH-------LENTHSCHPMSGECACKPGWSGLYC 396
           G +G  CE   C     G  CD+  P         + + ++C P    C C P       
Sbjct: 353 GLSGGVCED--CQHNTEGQHCDRCRPLFYRDPLKTISDPYACIP----CECDP------- 399

Query: 397 NETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRC 456
           + T S G        IC   +     SV G+C C    +G  C   C    YG++ +   
Sbjct: 400 DGTISGG--------ICVSHSDPALGSVAGQCLCKENVEGAKCDQ-CKPNHYGLSATDPL 450

Query: 457 GCKNDAVCSPVD-----------GSCTCKAGWHGVDCSIRCPSGTWGFGCNL----TCQC 501
           GC+    C+P+            G C C +   G  C   C  G WG G +L     C C
Sbjct: 451 GCQ-PCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCE-ECTVGYWGLGNHLHGCSPCDC 508

Query: 502 LNGGA----CNTLDGTCTCAPGWRGEKCELP 528
             GGA    C+  +G C C P   G  C  P
Sbjct: 509 DIGGAYSNVCSPKNGQCECRPHVTGRSCSEP 539



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 79/361 (21%), Positives = 128/361 (35%), Gaps = 65/361 (18%)

Query: 70  TRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAP-NTCQCEP 128
           T  R+++   +  G+  + RR++     +Y +         +  V G C    +  +C P
Sbjct: 224 TNLRINFTKLHTLGDALLGRRQNDSLDKYYYA-------LYEMIVRGSCFCNGHASECRP 276

Query: 129 GWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYG 188
                       GD + P      QC    +C   T   +C       RC+D  +   + 
Sbjct: 277 -------MQKMRGDVFSPPGMVHGQC----VCQHNTDGPNCE------RCKDFFQDAPWR 319

Query: 189 NDCHQRCQCQNGATCDHVTGECR-------CPPGYTGAFCEDLCPPGKHGPQCEQRCPCQ 241
                +       +C+  +  C           G +G  CED C     G  C++  P  
Sbjct: 320 PAADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCED-CQHNTEGQHCDRCRPLF 378

Query: 242 NGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPG 301
                  ++   +C           PC     G      C  H+     +  GQC C   
Sbjct: 379 YRDPLKTISDPYACI----------PCECDPDGTISGGICVSHSDPALGSVAGQCLCKEN 428

Query: 302 YTGERCQDECPVGTYGV-----LCAETCQCVNGGK-----CYHVSGACLCEAGFAGERCE 351
             G +C D+C    YG+     L  + C C   G      C   +G CLC +   G  CE
Sbjct: 429 VEGAKC-DQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCE 487

Query: 352 ARLCPEGLYGIK-----CDKRCPCHLENTHS--CHPMSGECACKPGWSGLYCNETCSPGF 404
              C  G +G+      C   C C +   +S  C P +G+C C+P  +G  C+E  +PG+
Sbjct: 488 E--CTVGYWGLGNHLHGCSP-CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEP-APGY 543

Query: 405 Y 405
           +
Sbjct: 544 F 544



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 70/292 (23%), Positives = 97/292 (33%), Gaps = 58/292 (19%)

Query: 542 CDCS-HADGCHPTT--------------GHCRCLPGWSGVHCD---SVCAEGRWGPNCSL 583
           C C+ HA  C P                G C C     G +C+       +  W P   L
Sbjct: 265 CFCNGHASECRPMQKMRGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADL 324

Query: 584 PCYCKNGASCSPDDGICE-------CAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSG 636
                   SC+     C         + G  G  C+  C     G  C +  P  +    
Sbjct: 325 QDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCED-CQHNTEGQHCDRCRP--LFYRD 381

Query: 637 PCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIG 696
           P   I+    C+P          C     G    GIC   ++     +   C C     G
Sbjct: 382 PLKTISDPYACIP----------CECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEG 431

Query: 697 SDCSQPCPPAHWG-----PNCIHTCNCHN-GAF----CSAYDGECKCTPGWTGLYCTQRC 746
           + C Q C P H+G     P     C+C+  G+     C    G+C C    TG +C + C
Sbjct: 432 AKCDQ-CKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHC-EEC 489

Query: 747 PLGFYGKDCALI----CQCQNGAD----CDHISGQCTCRTGFMGRHCEQKCP 790
            +G++G    L     C C  G      C   +GQC CR    GR C +  P
Sbjct: 490 TVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAP 541



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 56/195 (28%), Positives = 80/195 (41%), Gaps = 33/195 (16%)

Query: 673 CTCTNNGT----CNPIDRSCQCYPGWIGSDCSQPCPPAHW--GPNCIHTCNCH----NGA 722
           C C   G+    C+ +   CQC P  +G  C + C    +  G +  H C+CH       
Sbjct: 769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDR-CSTGSYDLGHHGCHPCHCHPQGSKDT 827

Query: 723 FCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGAD-CDHISGQCTCRTGFM 781
            C    G+C C    +G  C  RC  G++G      C C   A+ CD  +G C    GF 
Sbjct: 828 VCDQVTGQCPCHGEVSGRRC-DRCLAGYFGFPSCHPCPCNRFAELCDPETGSCFNCGGFT 886

Query: 782 -GRHCEQKCPSGTYG-----YGCRQICDCLNN-STCDHITGTCY-----------CSPGW 823
            GR+CE +C  G YG       CR  C C ++ S+  +   +CY           C  G+
Sbjct: 887 TGRNCE-RCIDGYYGNPSSGQPCRP-CLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGY 944

Query: 824 KGARCDQAGVIIVGN 838
            G +C +      GN
Sbjct: 945 TGTQCGECSTGFYGN 959



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 70/274 (25%), Positives = 94/274 (34%), Gaps = 55/274 (20%)

Query: 512 GTCTCAPGWRGEKCELPCQDGTYGL----------NCAERCDC-SHADGCHPTTGHCRCL 560
           G C C     G  CE  C+D               N    C C SH+  CH         
Sbjct: 293 GQCVCQHNTDGPNCER-CKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLAS 351

Query: 561 PGWSGVHCDSVCAEGRWGPNCSL--PCYCKNGASCSPDDGIC---ECAPGFRGTTCQRIC 615
            G SG  C+  C     G +C    P + ++      D   C   EC P   GT    IC
Sbjct: 352 GGLSGGVCED-CQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPD--GTISGGIC 408

Query: 616 SPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGI--- 672
                            HS      + G C C     GA C++ C    +G +       
Sbjct: 409 VS---------------HSDPALGSVAGQCLCKENVEGAKCDQ-CKPNHYGLSATDPLGC 452

Query: 673 --CTCTNNG-----TCNPIDRSCQCYPGWIGSDCSQPCPPAHWG-PNCIH---TCNCHNG 721
             C C   G     TC+     C C     G+ C + C   +WG  N +H    C+C  G
Sbjct: 453 QPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEE-CTVGYWGLGNHLHGCSPCDCDIG 511

Query: 722 A----FCSAYDGECKCTPGWTGLYCTQRCPLGFY 751
                 CS  +G+C+C P  TG  C++  P  F+
Sbjct: 512 GAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFF 545



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 67/261 (25%), Positives = 92/261 (35%), Gaps = 75/261 (28%)

Query: 671 GICTCTNNGT-CNPIDR--------------SCQCYPGWIGSDCSQPCPP----AHWGP- 710
           G C C  + + C P+ +               C C     G +C + C      A W P 
Sbjct: 263 GSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVCQHNTDGPNCER-CKDFFQDAPWRPA 321

Query: 711 -----NCIHTCNCHNGAFCSAYD------------GECK-CTPGWTGLYCTQRCPLGFYG 752
                N   +C+C++ +    +D            G C+ C     G +C +  PL FY 
Sbjct: 322 ADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPL-FYR 380

Query: 753 KDCALI--------CQCQ-----NGADC--------DHISGQCTCRTGFMGRHCEQKCP- 790
                I        C+C      +G  C          ++GQC C+    G  C+Q  P 
Sbjct: 381 DPLKTISDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPN 440

Query: 791 ----SGTYGYGCRQICDC-----LNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNS 841
               S T   GC Q CDC     L   TCD  TG C C     GA C++  V   G  N 
Sbjct: 441 HYGLSATDPLGC-QPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNH 499

Query: 842 LSRTSTALPADSYQIGAIAGI 862
           L   S   P D    GA + +
Sbjct: 500 LHGCS---PCDCDIGGAYSNV 517


>gi|167614504 laminin, beta 1 precursor [Homo sapiens]
          Length = 1786

 Score =  161 bits (407), Expect = 4e-39
 Identities = 124/389 (31%), Positives = 161/389 (41%), Gaps = 70/389 (17%)

Query: 124  CQCEPGWGGTNCSSACDGDH-WGPHCTSRCQC----KNGALCNPITGACHCAAGFRGWRC 178
            CQC P   G  C+    G   +GP     C+C       A CNP+TG CHC  G    +C
Sbjct: 792  CQCRPNVVGRTCNRCAPGTFGFGPSGCKPCECHLQGSVNAFCNPVTGQCHCFQGVYARQC 851

Query: 179  EDRCEQGTYGNDCHQRCQCQNGA-TCDHVTGECRCPPGYTGAFCEDLCPPGKH------- 230
             DRC  G +G    Q CQC   A  CD VTGEC     YT     + C  G +       
Sbjct: 852  -DRCLPGHWGFPSCQPCQCNGHADDCDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGS 910

Query: 231  GPQCEQRCPCQNG--------GVCHH--VTGE--CSCPSGWMGTVCGQPCPEGRFGK--- 275
            G  C + CPC +G          C+   VT +  C C  G++G+ C   C  G FG    
Sbjct: 911  GDHC-RPCPCPDGPDSGRQFARSCYQDPVTLQLACVCDPGYIGSRC-DDCASGYFGNPSE 968

Query: 276  --NCSQECQCHNG------GTCDAATGQC-HCSPGYTGERCQDECPVGTYGVLCAETC-Q 325
                 Q CQCHN         CD  TG+C  C     GE CQ  C  G YG    + C +
Sbjct: 969  VGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHCQ-FCRFGYYGDALQQDCRK 1027

Query: 326  CV-----------NGG--KCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRC-PCH 371
            CV           NG   +C   +G CLC     G+ C+   C    + +     C PC+
Sbjct: 1028 CVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCDR--CAPNTWQLASGTGCDPCN 1085

Query: 372  LENTH----SCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQ------NGADC 421
                H    SC+  +G+C C PG+ G  C+E C   F+G+   +  +C           C
Sbjct: 1086 CNAAHSFGPSCNEFTGQCQCMPGFGGRTCSE-CQELFWGDPDVECRACDCDPRGIETPQC 1144

Query: 422  DSVTGKCTCAPGFKGIDCSTPCPLGTYGI 450
            D  TG+C C  G +G  C   C  G  G+
Sbjct: 1145 DQSTGQCVCVEGVEGPRCD-KCTRGYSGV 1172



 Score =  160 bits (406), Expect = 5e-39
 Identities = 132/421 (31%), Positives = 171/421 (40%), Gaps = 85/421 (20%)

Query: 238  CPCQNGG----VCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCS--QECQCHNGGT--- 288
            C C   G    VC    G+C C    +G  C + C  G FG   S  + C+CH  G+   
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNR-CAPGTFGFGPSGCKPCECHLQGSVNA 831

Query: 289  -CDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNG--GKCYHVSGACL-CEAG 344
             C+  TGQCHC  G    +C D C  G +G    + CQC NG    C  V+G CL C+  
Sbjct: 832  FCNPVTGQCHCFQGVYARQC-DRCLPGHWGFPSCQPCQC-NGHADDCDPVTGECLNCQDY 889

Query: 345  FAGERCEARLCPEGLYGIKC------DKRCPC------HLENTHSCH----PMSGECACK 388
              G  CE   C  G YG          + CPC        +   SC+     +   C C 
Sbjct: 890  TMGHNCER--CLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACVCD 947

Query: 389  PGWSGLYCNETCSPGFYGEACQ-----QICSCQNGAD------CDSVTGKC-TCAPGFKG 436
            PG+ G  C++ C+ G++G   +     Q C C N  D      CD  TG+C  C    +G
Sbjct: 948  PGYIGSRCDD-CASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEG 1006

Query: 437  IDCSTPCPLGTYGINCSS---RCGCK-----------NDAVCSPVDGSCTCKAGWHGVDC 482
              C   C  G YG        +C C            +D  C    G C C     G +C
Sbjct: 1007 EHCQF-CRFGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNC 1065

Query: 483  SIRCPSGTW----GFGCNLTCQC----LNGGACNTLDGTCTCAPGWRGEKCELPCQDGTY 534
              RC   TW    G GC+  C C      G +CN   G C C PG+ G  C   CQ+  +
Sbjct: 1066 D-RCAPNTWQLASGTGCD-PCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCS-ECQELFW 1122

Query: 535  G---LNCAERCDCS----HADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWG--PNCSLPC 585
            G   + C   CDC         C  +TG C C+ G  G  CD  C  G  G  P+C+ PC
Sbjct: 1123 GDPDVEC-RACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDK-CTRGYSGVFPDCT-PC 1179

Query: 586  Y 586
            +
Sbjct: 1180 H 1180



 Score =  149 bits (377), Expect = 1e-35
 Identities = 125/414 (30%), Positives = 173/414 (41%), Gaps = 79/414 (19%)

Query: 449  GINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCN--LTCQCLNGGA 506
            G+ C         +VC P  G C C+    G  C+ RC  GT+GFG +    C+C   G+
Sbjct: 770  GLACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCN-RCAPGTFGFGPSGCKPCECHLQGS 828

Query: 507  ----CNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCS-HADGCHPTTGHC-RCL 560
                CN + G C C  G    +C+  C  G +G    + C C+ HAD C P TG C  C 
Sbjct: 829  VNAFCNPVTGQCHCFQGVYARQCD-RCLPGHWGFPSCQPCQCNGHADDCDPVTGECLNCQ 887

Query: 561  PGWSGVHCDSVCAEGRW-------GPNCSLPCYCKNG--------ASCSPD----DGICE 601
                G +C+  C  G +       G +C  PC C +G         SC  D       C 
Sbjct: 888  DYTMGHNCER-CLAGYYGDPIIGSGDHCR-PCPCPDGPDSGRQFARSCYQDPVTLQLACV 945

Query: 602  CAPGFRGTTCQRICSPGFYGH--RCSQTCPQC-----VHSSGP--CHHITGLC-DCLPGF 651
            C PG+ G+ C   C+ G++G+      +C  C     + ++ P  C   TG C  CL   
Sbjct: 946  CDPGYIGSRCDD-CASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHT 1004

Query: 652  TGALCNEVCPSGRFG----KNCAGICTCTNNGT-----------CNPIDRSCQCYPGWIG 696
             G  C + C  G +G    ++C   C C   GT           C+     C C P  IG
Sbjct: 1005 EGEHC-QFCRFGYYGDALQQDCRK-CVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIG 1062

Query: 697  SDCSQPCPPAHW----GPNCIHTCNCHN----GAFCSAYDGECKCTPGWTGLYCTQRCPL 748
             +C + C P  W    G  C   CNC+     G  C+ + G+C+C PG+ G  C++ C  
Sbjct: 1063 QNCDR-CAPNTWQLASGTGC-DPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSE-CQE 1119

Query: 749  GFYGK---DCALICQCQ----NGADCDHISGQCTCRTGFMGRHCEQKCPSGTYG 795
             F+G    +C   C C         CD  +GQC C  G  G  C+ KC  G  G
Sbjct: 1120 LFWGDPDVECR-ACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCD-KCTRGYSG 1171



 Score =  143 bits (361), Expect = 8e-34
 Identities = 117/409 (28%), Positives = 164/409 (40%), Gaps = 76/409 (18%)

Query: 195  CQCQN----GATCDHVTGECRCPPGYTGAFCEDLCPPGK--HGPQCEQRCPCQNGG---- 244
            C+C       + CD   G+C+C P   G  C + C PG    GP   + C C   G    
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTC-NRCAPGTFGFGPSGCKPCECHLQGSVNA 831

Query: 245  VCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCH-NGGTCDAATGQC-HCSPGY 302
             C+ VTG+C C  G     C + C  G +G    Q CQC+ +   CD  TG+C +C    
Sbjct: 832  FCNPVTGQCHCFQGVYARQCDR-CLPGHWGFPSCQPCQCNGHADDCDPVTGECLNCQDYT 890

Query: 303  TGERCQDECPVGTYGVLC------AETCQCVNG--------GKCYH----VSGACLCEAG 344
             G  C + C  G YG            C C +G          CY     +  AC+C+ G
Sbjct: 891  MGHNC-ERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACVCDPG 949

Query: 345  FAGERCEARLCPEGLYGIKCD-----KRCPCH----LENTHSCHPMSGEC-ACKPGWSGL 394
            + G RC+   C  G +G   +     + C CH      +  +C   +G C  C     G 
Sbjct: 950  YIGSRCDD--CASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGE 1007

Query: 395  YCNETCSPGFYGEACQQICS---CQ---------NGAD--CDSVTGKCTCAPGFKGIDCS 440
            +C + C  G+YG+A QQ C    C          NG+D  CD  TG+C C P   G +C 
Sbjct: 1008 HC-QFCRFGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCD 1066

Query: 441  TPCPLGTYGINCSSRCG-CKNDAV------CSPVDGSCTCKAGWHGVDCSIRCPSGTWG- 492
              C   T+ +   + C  C  +A       C+   G C C  G+ G  CS  C    WG 
Sbjct: 1067 R-CAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCS-ECQELFWGD 1124

Query: 493  -----FGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGL 536
                   C+   + +    C+   G C C  G  G +C+  C  G  G+
Sbjct: 1125 PDVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCD-KCTRGYSGV 1172



 Score =  143 bits (360), Expect = 1e-33
 Identities = 127/412 (30%), Positives = 160/412 (38%), Gaps = 82/412 (19%)

Query: 324  CQCVNGGK----CYHVSGACLCEAGFAGERCEARLCPEGLYGIKCD--KRCPCHLENTHS 377
            C+C   G     C    G C C     G  C    C  G +G      K C CHL+ + +
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNR--CAPGTFGFGPSGCKPCECHLQGSVN 830

Query: 378  --CHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGAD-CDSVTGKC-TCAPG 433
              C+P++G+C C  G     C+  C PG +G    Q C C   AD CD VTG+C  C   
Sbjct: 831  AFCNPVTGQCHCFQGVYARQCDR-CLPGHWGFPSCQPCQCNGHADDCDPVTGECLNCQDY 889

Query: 434  FKGIDCSTPCPLGTYG---INCSSRC-----------------GCKNDAVCSPVDGSCTC 473
              G +C   C  G YG   I     C                  C  D V   +  +C C
Sbjct: 890  TMGHNCER-CLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQL--ACVC 946

Query: 474  KAGWHGVDCSIRCPSGTWG-----FGCNLTCQCLNG------GACNTLDGTC-TCAPGWR 521
              G+ G  C   C SG +G      G    CQC N        AC+   G C  C     
Sbjct: 947  DPGYIGSRCD-DCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTE 1005

Query: 522  GEKCELPCQDGTYG---LNCAERCDCS-------HADG----CHPTTGHCRCLPGWSGVH 567
            GE C+  C+ G YG        +C C+       H +G    C   TG C CLP   G +
Sbjct: 1006 GEHCQF-CRFGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQN 1064

Query: 568  CDSVCAEGRW----GPNCSLPCYCKN----GASCSPDDGICECAPGFRGTTCQRICSPGF 619
            CD  CA   W    G  C  PC C      G SC+   G C+C PGF G TC   C   F
Sbjct: 1065 CDR-CAPNTWQLASGTGCD-PCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSE-CQELF 1121

Query: 620  YGH-----RCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFG 666
            +G      R     P+ + +   C   TG C C+ G  G  C++ C  G  G
Sbjct: 1122 WGDPDVECRACDCDPRGIETP-QCDQSTGQCVCVEGVEGPRCDK-CTRGYSG 1171



 Score =  139 bits (349), Expect = 2e-32
 Identities = 130/432 (30%), Positives = 165/432 (38%), Gaps = 104/432 (24%)

Query: 152  CQCKN----GALCNPITGACHCAAGFRGWRCEDRCEQGTYG------NDCHQRCQCQNGA 201
            C+C       ++C+P  G C C     G  C +RC  GT+G        C    Q    A
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTC-NRCAPGTFGFGPSGCKPCECHLQGSVNA 831

Query: 202  TCDHVTGECRCPPGYTGAFCEDLCPPGKHG-PQCEQRCPCQNGG---VCHHVTGEC-SCP 256
             C+ VTG+C C  G     C D C PG  G P C+   PCQ  G    C  VTGEC +C 
Sbjct: 832  FCNPVTGQCHCFQGVYARQC-DRCLPGHWGFPSCQ---PCQCNGHADDCDPVTGECLNCQ 887

Query: 257  SGWMGTVCGQ--------------------PCPEG-----RFGKNCSQECQCHNGGTCDA 291
               MG  C +                    PCP+G     +F ++C Q          D 
Sbjct: 888  DYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQ----------DP 937

Query: 292  ATGQ--CHCSPGYTGERCQDECPVGTYGVL-----CAETCQCVNG------GKCYHVSGA 338
             T Q  C C PGY G RC D+C  G +G         + CQC N         C   +G 
Sbjct: 938  VTLQLACVCDPGYIGSRC-DDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGR 996

Query: 339  CL-CEAGFAGERCEARLCPEGLYGIKCD---KRCPCHLENT---------HSCHPMSGEC 385
            CL C     GE C+   C  G YG       ++C C+   T           C   +G+C
Sbjct: 997  CLKCLYHTEGEHCQ--FCRFGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQC 1054

Query: 386  ACKPGWSGLYCNETCSPGFY----GEACQQICSCQN----GADCDSVTGKCTCAPGFKGI 437
             C P   G  C + C+P  +    G  C   C+C      G  C+  TG+C C PGF G 
Sbjct: 1055 LCLPNVIGQNC-DRCAPNTWQLASGTGCDP-CNCNAAHSFGPSCNEFTGQCQCMPGFGGR 1112

Query: 438  DCSTPCPL--GTYGINCSSRCGCKNDAV----CSPVDGSCTCKAGWHGVDCSIRCPSGTW 491
             CS    L  G   + C + C C    +    C    G C C  G  G  C  +C  G  
Sbjct: 1113 TCSECQELFWGDPDVECRA-CDCDPRGIETPQCDQSTGQCVCVEGVEGPRCD-KCTRGYS 1170

Query: 492  GF--GCNLTCQC 501
            G    C    QC
Sbjct: 1171 GVFPDCTPCHQC 1182



 Score =  138 bits (347), Expect = 3e-32
 Identities = 126/405 (31%), Positives = 157/405 (38%), Gaps = 82/405 (20%)

Query: 497  LTCQCLNGGA----CNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCA--ERCDCSHADG- 549
            L C+C   G+    C+   G C C P   G  C   C  GT+G   +  + C+C H  G 
Sbjct: 771  LACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNR-CAPGTFGFGPSGCKPCEC-HLQGS 828

Query: 550  ----CHPTTGHCRCLPGWSGVHCDSVCAEGRWG-PNCSLPCYCKNGAS-CSPDDGIC-EC 602
                C+P TG C C  G     CD  C  G WG P+C  PC C   A  C P  G C  C
Sbjct: 829  VNAFCNPVTGQCHCFQGVYARQCDR-CLPGHWGFPSCQ-PCQCNGHADDCDPVTGECLNC 886

Query: 603  APGFRGTTCQRICSPGFYGHRC---SQTCPQCVHSSGP---------CHH----ITGLCD 646
                 G  C+R C  G+YG         C  C    GP         C+     +   C 
Sbjct: 887  QDYTMGHNCER-CLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACV 945

Query: 647  CLPGFTGALCNEVCPSGRFGK------NCAGICTCTNN-------------GTC-----N 682
            C PG+ G+ C++ C SG FG       +C   C C NN             G C     +
Sbjct: 946  CDPGYIGSRCDD-CASGYFGNPSEVGGSCQP-CQCHNNIDTTDPEACDKETGRCLKCLYH 1003

Query: 683  PIDRSCQ-CYPGWIGSDCSQPCPPAHWGPNCIHTCNCH-NGAFCSA--YDGECKCTPGWT 738
                 CQ C  G+ G    Q C       N + T   H NG+ C      G+C C P   
Sbjct: 1004 TEGEHCQFCRFGYYGDALQQDCRKCVC--NYLGTVQEHCNGSDCQCDKATGQCLCLPNVI 1061

Query: 739  GLYCTQRCPLGFY---GKDCALICQCQN----GADCDHISGQCTCRTGFMGRHCE--QKC 789
            G  C +  P  +    G  C   C C      G  C+  +GQC C  GF GR C   Q+ 
Sbjct: 1062 GQNCDRCAPNTWQLASGTGCDP-CNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQEL 1120

Query: 790  PSGTYGYGCRQICDC----LNNSTCDHITGTCYCSPGWKGARCDQ 830
              G     CR  CDC    +    CD  TG C C  G +G RCD+
Sbjct: 1121 FWGDPDVECR-ACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDK 1164



 Score =  134 bits (337), Expect = 5e-31
 Identities = 123/437 (28%), Positives = 166/437 (37%), Gaps = 89/437 (20%)

Query: 281  CQCHNGGT----CDAATGQCHCSPGYTGERCQDECPVGTYGV--LCAETCQCVNGGK--- 331
            C+C   G+    CD   GQC C P   G  C + C  GT+G      + C+C   G    
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTC-NRCAPGTFGFGPSGCKPCECHLQGSVNA 831

Query: 332  -CYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECA-CKP 389
             C  V+G C C  G    +C+   C  G +G    + C C+  +   C P++GEC  C+ 
Sbjct: 832  FCNPVTGQCHCFQGVYARQCDR--CLPGHWGFPSCQPCQCN-GHADDCDPVTGECLNCQD 888

Query: 390  GWSGLYCNETCSPGFYGEA-------CQQICSCQNGADC----------DSVTGK--CTC 430
               G  C E C  G+YG+        C+  C C +G D           D VT +  C C
Sbjct: 889  YTMGHNC-ERCLAGYYGDPIIGSGDHCRP-CPCPDGPDSGRQFARSCYQDPVTLQLACVC 946

Query: 431  APGFKGIDCSTPCPLGTYG-----------INCSSRCGCKNDAVCSPVDGSC-TCKAGWH 478
             PG+ G  C   C  G +G             C +     +   C    G C  C     
Sbjct: 947  DPGYIGSRCD-DCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTE 1005

Query: 479  GVDCSIRCPSGTWGFGCNLTC-QCL-----------NGG--ACNTLDGTCTCAPGWRGEK 524
            G  C   C  G +G      C +C+           NG    C+   G C C P   G+ 
Sbjct: 1006 GEHCQF-CRFGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQN 1064

Query: 525  CELPCQDGTYGLNCAERCD-----CSHADG--CHPTTGHCRCLPGWSGVHCDSVCAEGRW 577
            C+  C   T+ L     CD      +H+ G  C+  TG C+C+PG+ G  C S C E  W
Sbjct: 1065 CD-RCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTC-SECQELFW 1122

Query: 578  G-PNCSL-PCYCK----NGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQC 631
            G P+     C C         C    G C C  G  G  C + C+ G+ G       P C
Sbjct: 1123 GDPDVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDK-CTRGYSG-----VFPDC 1176

Query: 632  VHSSGPCHHITGLCDCL 648
                 PCH    L D +
Sbjct: 1177 T----PCHQCFALWDVI 1189



 Score =  130 bits (327), Expect = 7e-30
 Identities = 109/361 (30%), Positives = 146/361 (40%), Gaps = 73/361 (20%)

Query: 542  CDC----SHADGCHPTTGHCRCLPGWSGVHCDSVCAEGR--WGPNCSLPCYC----KNGA 591
            C+C    S +  C P  G C+C P   G  C+  CA G   +GP+   PC C       A
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNR-CAPGTFGFGPSGCKPCECHLQGSVNA 831

Query: 592  SCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLC-DCLPG 650
             C+P  G C C  G     C R C PG +G    Q C QC   +  C  +TG C +C   
Sbjct: 832  FCNPVTGQCHCFQGVYARQCDR-CLPGHWGFPSCQPC-QCNGHADDCDPVTGECLNCQDY 889

Query: 651  FTGALCNEVCPSGRFGKNCAGI------CTCTNNGTCN------------PIDRSCQCYP 692
              G  C E C +G +G    G       C C +                  +  +C C P
Sbjct: 890  TMGHNC-ERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACVCDP 948

Query: 693  GWIGSDCSQPCP-----PAHWGPNCIHTCNCHNG------AFCSAYDGEC-KCTPGWTGL 740
            G+IGS C          P+  G +C   C CHN         C    G C KC     G 
Sbjct: 949  GYIGSRCDDCASGYFGNPSEVGGSC-QPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGE 1007

Query: 741  YCTQRCPLGFYG----KDCALICQCQ---------NGAD--CDHISGQCTCRTGFMGRHC 785
            +C Q C  G+YG    +DC   C C          NG+D  CD  +GQC C    +G++C
Sbjct: 1008 HC-QFCRFGYYGDALQQDCRK-CVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNC 1065

Query: 786  EQKCPSGTY----GYGCRQICDC----LNNSTCDHITGTCYCSPGWKGARCDQAGVIIVG 837
            + +C   T+    G GC   C+C        +C+  TG C C PG+ G  C +   +  G
Sbjct: 1066 D-RCAPNTWQLASGTGC-DPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWG 1123

Query: 838  N 838
            +
Sbjct: 1124 D 1124



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 83/307 (27%), Positives = 108/307 (35%), Gaps = 84/307 (27%)

Query: 88  YRRKSQCCP--GFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDH-- 143
           Y   S+C P  GF E  E          VHG C+      C     G NC    D  H  
Sbjct: 274 YGHASECAPVDGFNEEVE--------GMVHGHCM------CRHNTKGLNCELCMDFYHDL 319

Query: 144 -WGP------HCTSRCQCKNGALCNPITGACHCAAG-FRGWRCEDRCEQGTYGNDCHQRC 195
            W P      +   +C C   ++      A + A G   G  C+D C+  T G +C Q  
Sbjct: 320 PWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDD-CQHNTMGRNCEQ-- 376

Query: 196 QCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPC-----QNGGVCHHVT 250
                           C P Y      D+  P      CE RC C     QN G+C   T
Sbjct: 377 ----------------CKPFYYQHPERDIRDPNF----CE-RCTCDPAGSQNEGICDSYT 415

Query: 251 --------GECSCPSGWMGTVCGQPCPEGRFGKNCS-----QECQCHNGGT------CDA 291
                   G+C C     G  C   C EG +  +       + C C+  GT      CD+
Sbjct: 416 DFSTGLIAGQCRCKLNVEGEHC-DVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDS 474

Query: 292 ATGQCHCSPGYTGERCQDECPVGTYGVL----CAETCQCVNGG----KCYHVSGACLCEA 343
            TG C+C    TG+ C D+C    +G+         C C  GG     C+  SG C C  
Sbjct: 475 ETGHCYCKRLVTGQHC-DQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCFAESGQCSCRP 533

Query: 344 GFAGERC 350
              G +C
Sbjct: 534 HMIGRQC 540



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 72/262 (27%), Positives = 94/262 (35%), Gaps = 69/262 (26%)

Query: 206 VTGECRCPPGYTGAFCEDLC-----------PPGKHGPQCEQRCPCQNGGV-CHHVTGEC 253
           V G C C     G  CE LC             G++   C+ +C C    + CH      
Sbjct: 294 VHGHCMCRHNTKGLNCE-LCMDFYHDLPWRPAEGRNSNACK-KCNCNEHSISCHFDMAVY 351

Query: 254 SCPSGWMGTVCGQPCPEGRFGKNCSQ--------------------ECQC-----HNGGT 288
                  G VC   C     G+NC Q                     C C      N G 
Sbjct: 352 LATGNVSGGVCDD-CQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGI 410

Query: 289 CDAAT--------GQCHCSPGYTGERCQDECPVGTYGVLCAE-----TCQC------VNG 329
           CD+ T        GQC C     GE C D C  G Y +   +     +C C        G
Sbjct: 411 CDSYTDFSTGLIAGQCRCKLNVEGEHC-DVCKEGFYDLSSEDPFGCKSCACNPLGTIPGG 469

Query: 330 GKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCD----KRCPCHLENT--HSCHPMSG 383
             C   +G C C+    G+ C+  L PE  +G+  D    + C C L     +SC   SG
Sbjct: 470 NPCDSETGHCYCKRLVTGQHCDQCL-PEH-WGLSNDLDGCRPCDCDLGGALNNSCFAESG 527

Query: 384 ECACKPGWSGLYCNETCSPGFY 405
           +C+C+P   G  CNE   PG+Y
Sbjct: 528 QCSCRPHMIGRQCNEV-EPGYY 548



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 78/301 (25%), Positives = 107/301 (35%), Gaps = 84/301 (27%)

Query: 585 CYCKNGAS-CSPDDGI-----------CECAPGFRGTTCQRICSPGFYG-------HRCS 625
           C+C   AS C+P DG            C C    +G  C+ +C   ++         R S
Sbjct: 271 CFCYGHASECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCE-LCMDFYHDLPWRPAEGRNS 329

Query: 626 QTCPQCV--HSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNP 683
             C +C     S  CH    +       +G +C++ C     G+NC              
Sbjct: 330 NACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDD-CQHNTMGRNCE------------- 375

Query: 684 IDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNC-----HNGAFCSAYD--------GE 730
                QC P +      Q        PN    C C      N   C +Y         G+
Sbjct: 376 -----QCKPFYY-----QHPERDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQ 425

Query: 731 CKCTPGWTGLYCTQRCPLGFYG---------KDCAL--ICQCQNGADCDHISGQCTCRTG 779
           C+C     G +C   C  GFY          K CA   +     G  CD  +G C C+  
Sbjct: 426 CRCKLNVEGEHCDV-CKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRL 484

Query: 780 FMGRHCEQKCPSGTYGY-----GCRQICDC-----LNNSTCDHITGTCYCSPGWKGARCD 829
             G+HC+Q C    +G      GCR  CDC     LNNS C   +G C C P   G +C+
Sbjct: 485 VTGQHCDQ-CLPEHWGLSNDLDGCRP-CDCDLGGALNNS-CFAESGQCSCRPHMIGRQCN 541

Query: 830 Q 830
           +
Sbjct: 542 E 542



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 78/297 (26%), Positives = 96/297 (32%), Gaps = 62/297 (20%)

Query: 413 CSCQNGA-DCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDG-- 469
           C C   A +C  V G      G     C   C   T G+NC       +D    P +G  
Sbjct: 271 CFCYGHASECAPVDGFNEEVEGMVHGHCM--CRHNTKGLNCELCMDFYHDLPWRPAEGRN 328

Query: 470 --SCT-CKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCE 526
             +C  C    H + C        +     L    ++GG C+       C     G  CE
Sbjct: 329 SNACKKCNCNEHSISCH-------FDMAVYLATGNVSGGVCDD------CQHNTMGRNCE 375

Query: 527 LPCQDGTY--------GLNCAERCDCSHADG-----CHPTT--------GHCRCLPGWSG 565
             C+   Y          N  ERC C  A       C   T        G CRC     G
Sbjct: 376 -QCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEG 434

Query: 566 VHCDSVCAEGRWGPNCSLPCYCKN-----------GASCSPDDGICECAPGFRGTTCQRI 614
            HCD VC EG +  +   P  CK+           G  C  + G C C     G  C + 
Sbjct: 435 EHCD-VCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQ- 492

Query: 615 CSPGFYG-HRCSQTCPQCVHSSG-----PCHHITGLCDCLPGFTGALCNEVCPSGRF 665
           C P  +G       C  C    G      C   +G C C P   G  CNEV P   F
Sbjct: 493 CLPEHWGLSNDLDGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPGYYF 549



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 77/305 (25%), Positives = 101/305 (33%), Gaps = 70/305 (22%)

Query: 534 YGLNCAERCDC-SHADGCHPTTG-----------HCRCLPGWSGVHCDSVC--------- 572
           Y +     C C  HA  C P  G           HC C     G++C+ +C         
Sbjct: 263 YDMVVRGNCFCYGHASECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCE-LCMDFYHDLPW 321

Query: 573 --AEGRWGPNCSLPCYC-KNGASCSPD-----------DGICE-CAPGFRGTTCQRICSP 617
             AEGR   N    C C ++  SC  D            G+C+ C     G  C++ C P
Sbjct: 322 RPAEGR-NSNACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQ-CKP 379

Query: 618 GFYGH-----RCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGI 672
            +Y H     R    C +C        +  G+CD    F+  L              AG 
Sbjct: 380 FYYQHPERDIRDPNFCERCTCDPAGSQN-EGICDSYTDFSTGLI-------------AGQ 425

Query: 673 CTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECK 732
           C C  N      D    C  G+       P        N + T     G  C +  G C 
Sbjct: 426 CRCKLNVEGEHCD---VCKEGFYDLSSEDPFGCKSCACNPLGTIP--GGNPCDSETGHCY 480

Query: 733 CTPGWTGLYCTQRCPLGF---YGKDCALICQCQNGA----DCDHISGQCTCRTGFMGRHC 785
           C    TG +C Q  P  +      D    C C  G      C   SGQC+CR   +GR C
Sbjct: 481 CKRLVTGQHCDQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQC 540

Query: 786 EQKCP 790
            +  P
Sbjct: 541 NEVEP 545



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 62/265 (23%), Positives = 86/265 (32%), Gaps = 47/265 (17%)

Query: 249 VTGECSCPSGWMGTVCGQPC-----------PEGRFGKNCSQECQCHNGGTCDAATGQCH 297
           V G C C     G  C + C            EGR   N  ++C C+            +
Sbjct: 294 VHGHCMCRHNTKGLNC-ELCMDFYHDLPWRPAEGR-NSNACKKCNCNEHSISCHFDMAVY 351

Query: 298 CSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPE 357
            + G       D+C   T G  C E C+       Y      + +  F  ERC       
Sbjct: 352 LATGNVSGGVCDDCQHNTMGRNC-EQCKPFY----YQHPERDIRDPNFC-ERCTCDPAGS 405

Query: 358 GLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGE---------- 407
              GI       C      S   ++G+C CK    G +C + C  GFY            
Sbjct: 406 QNEGI-------CDSYTDFSTGLIAGQCRCKLNVEGEHC-DVCKEGFYDLSSEDPFGCKS 457

Query: 408 -ACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGIN--------CSSRCGC 458
            AC  + +   G  CDS TG C C     G  C   C    +G++        C    G 
Sbjct: 458 CACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCD-QCLPEHWGLSNDLDGCRPCDCDLGG 516

Query: 459 KNDAVCSPVDGSCTCKAGWHGVDCS 483
             +  C    G C+C+    G  C+
Sbjct: 517 ALNNSCFAESGQCSCRPHMIGRQCN 541



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 44/178 (24%), Positives = 66/178 (37%), Gaps = 38/178 (21%)

Query: 86  TMYRRKSQCCPGFYESGEMCV--PHCADKCV--------HGRC---------IAPNTCQC 126
           TM R   QC P +Y+  E  +  P+  ++C          G C         +    C+C
Sbjct: 369 TMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRC 428

Query: 127 EPGWGGTNCSSACDGDH----WGPHCTSRCQCK------NGALCNPITGACHCAAGFRGW 176
           +    G +C    +G +      P     C C        G  C+  TG C+C     G 
Sbjct: 429 KLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQ 488

Query: 177 RCEDRCEQGTYG--NDCH--QRCQCQNGA----TCDHVTGECRCPPGYTGAFCEDLCP 226
            C D+C    +G  ND    + C C  G     +C   +G+C C P   G  C ++ P
Sbjct: 489 HC-DQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEP 545


>gi|110735443 delta-like 1 [Homo sapiens]
          Length = 723

 Score =  150 bits (380), Expect = 5e-36
 Identities = 115/386 (29%), Positives = 153/386 (39%), Gaps = 101/386 (26%)

Query: 89  RRKSQCCPGF---YESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWG 145
           R +  C PG+   Y +  +C+P C ++  HG C  P  C+C  GW G  C          
Sbjct: 207 RGEKVCNPGWKGPYCTEPICLPGCDEQ--HGFCDKPGECKCRVGWQGRYCD--------- 255

Query: 146 PHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDH 205
             C     C +G    P    C+C  G+ G  C          N C     C+NGATC +
Sbjct: 256 -ECIRYPGCLHGTCQQP--WQCNCQEGWGGLFCNQDL------NYCTHHKPCKNGATCTN 306

Query: 206 VTGE----CRCPPGYTGAFCE---DLCPPGKHGPQCEQRCPCQNGGVCHHVTG--ECSCP 256
            TG+    C C PGYTGA CE   D C P           PC+NGG C  +     C+CP
Sbjct: 307 -TGQGSYTCSCRPGYTGATCELGIDECDPS----------PCKNGGSCTDLENSYSCTCP 355

Query: 257 SGWMGTVC---GQPCPEGRFGKNCSQECQCHNGGTC-DAATG--QCHCSPGYTGERCQDE 310
            G+ G +C      C +G           C NGG C D+  G   C C  GY+G  C+ +
Sbjct: 356 PGFYGKICELSAMTCADG----------PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKK 405

Query: 311 CPVGTYGVLCAETCQCVNGGKCYHVSGA--CLCEAGFAGERCEARLCPEGLYGIKCDKRC 368
                  +    +  C NG KC  +  A  C C+AGF+G  C+                 
Sbjct: 406 -------IDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCD----------------- 441

Query: 369 PCHLENTHSC--HPMSGECACKPGWSGLYCNETCSPGFYGEACQQICS------CQNGAD 420
               +N   C   P +    C+ G +   C  TC PG+ G  C    S      C NGA 
Sbjct: 442 ----DNVDDCASSPCANGGTCRDGVNDFSC--TCPPGYTGRNCSAPVSRCEHAPCHNGAT 495

Query: 421 CDSVTGK--CTCAPGFKGIDCSTPCP 444
           C     +  C CA G+ G +C    P
Sbjct: 496 CHERGHRYVCECARGYGGPNCQFLLP 521



 Score =  135 bits (341), Expect = 2e-31
 Identities = 121/426 (28%), Positives = 167/426 (39%), Gaps = 115/426 (26%)

Query: 268 CPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCV 327
           C E  +G+ CS  C+       D A G   C     GER +  C  G  G  C E   C+
Sbjct: 179 CDEHYYGEGCSVFCRPR-----DDAFGHFTC-----GERGEKVCNPGWKGPYCTEPI-CL 227

Query: 328 NGGKCYH----VSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSG 383
            G    H      G C C  G+ G  C+           +C +   C     H       
Sbjct: 228 PGCDEQHGFCDKPGECKCRVGWQGRYCD-----------ECIRYPGC----LHGTCQQPW 272

Query: 384 ECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGK----CTCAPGFKGIDC 439
           +C C+ GW GL+CN+  +       C     C+NGA C + TG+    C+C PG+ G  C
Sbjct: 273 QCNCQEGWGGLFCNQDLN------YCTHHKPCKNGATCTN-TGQGSYTCSCRPGYTGATC 325

Query: 440 STPCPLGTYGINCSSRCGCKNDAVCSPVDG--SCTCKAGWHGVDCSIRCPSGTWGFGCNL 497
                    GI+      CKN   C+ ++   SCTC  G++G  C +            +
Sbjct: 326 E-------LGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSA----------M 368

Query: 498 TC---QCLNGGAC-NTLDG--TCTCAPGWRGEKCE--------LPCQDGTYGLNCAERCD 543
           TC    C NGG C ++ DG  +C C  G+ G  CE         PC +G     C +  D
Sbjct: 369 TCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGA---KCVDLGD 425

Query: 544 CSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECA 603
                        CRC  G+SG HCD    +    P       C NG +C   DG+ + +
Sbjct: 426 AY----------LCRCQAGFSGRHCDDNVDDCASSP-------CANGGTCR--DGVNDFS 466

Query: 604 PGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCH-----HITG---LCDCLPGFTGAL 655
                 TC     PG+ G  CS    +C H+  PCH     H  G   +C+C  G+ G  
Sbjct: 467 -----CTC----PPGYTGRNCSAPVSRCEHA--PCHNGATCHERGHRYVCECARGYGGPN 515

Query: 656 CNEVCP 661
           C  + P
Sbjct: 516 CQFLLP 521



 Score =  110 bits (276), Expect = 6e-24
 Identities = 117/464 (25%), Positives = 163/464 (35%), Gaps = 132/464 (28%)

Query: 516 CAPGWRGEKCELPCQ--DGTYG-LNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVC 572
           C   + GE C + C+  D  +G   C ER             G   C PGW G +C    
Sbjct: 179 CDEHYYGEGCSVFCRPRDDAFGHFTCGER-------------GEKVCNPGWKGPYCTE-- 223

Query: 573 AEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCV 632
                 P C   C  ++G    P  G C+C  G++G  C                 P C+
Sbjct: 224 ------PICLPGCDEQHGFCDKP--GECKCRVGWQGRYCDECIR-----------YPGCL 264

Query: 633 HSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYP 692
           H  G C      C+C  G+ G  CN+        K C    TCTN G  +    +C C P
Sbjct: 265 H--GTCQQ-PWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGS---YTCSCRP 318

Query: 693 GWIGSDC-------------------------SQPCPPAHWGPNC---IHTC---NCHNG 721
           G+ G+ C                         S  CPP  +G  C     TC    C NG
Sbjct: 319 GYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNG 378

Query: 722 AFCS-AYDG--ECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQ--CTC 776
             CS + DG   C+C  G++G  C ++        D      C NGA C  +     C C
Sbjct: 379 GRCSDSPDGGYSCRCPVGYSGFNCEKKI-------DYCSSSPCSNGAKCVDLGDAYLCRC 431

Query: 777 RTGFMGRHCEQK-------------------------CPSGTYGYGCR------QICDCL 805
           + GF GRHC+                           CP G  G  C       +   C 
Sbjct: 432 QAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCH 491

Query: 806 NNSTCDHITG---TCYCSPGWKGARCD------QAGVIIVGNLNSLSRTSTALPADSYQI 856
           N +TC H  G    C C+ G+ G  C         G  +V     L       P     +
Sbjct: 492 NGATC-HERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFP----WV 546

Query: 857 GAIAGIIILVLVVLFLLALFIIYRHK-QKGKESSMPAVTYTPAM 899
              AG+I++++++L   A+ +  R + QK +  + P    T  M
Sbjct: 547 AVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETM 590



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 85/306 (27%), Positives = 105/306 (34%), Gaps = 96/306 (31%)

Query: 614 ICSPGFYGHRCSQTCPQCVHSSGPCHHIT----GLCDCLPGFTGALCNE-VCP------- 661
           +C   +YG  CS  C     + G   H T    G   C PG+ G  C E +C        
Sbjct: 178 VCDEHYYGEGCSVFCRPRDDAFG---HFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQH 234

Query: 662 ---------------SGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPC--- 703
                           GR+   C     C  +GTC      C C  GW G  C+Q     
Sbjct: 235 GFCDKPGECKCRVGWQGRYCDECIRYPGCL-HGTCQQ-PWQCNCQEGWGGLFCNQDLNYC 292

Query: 704 ---PPAHWGPNCI------HTCNC---HNGAFCSAYDGECKCTPGWTGLYCTQ------- 744
               P   G  C       +TC+C   + GA C     EC  +P   G  CT        
Sbjct: 293 THHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSC 352

Query: 745 RCPLGFYGKDC---ALIC---QCQNGADC-DHISG--QCTCRTGFMGRHCEQK------- 788
            CP GFYGK C   A+ C    C NG  C D   G   C C  G+ G +CE+K       
Sbjct: 353 TCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSS 412

Query: 789 ------------------CPSGTYGYGCRQICD------CLNNSTC-DHITG-TCYCSPG 822
                             C +G  G  C    D      C N  TC D +   +C C PG
Sbjct: 413 PCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPG 472

Query: 823 WKGARC 828
           + G  C
Sbjct: 473 YTGRNC 478



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 69/219 (31%), Positives = 86/219 (39%), Gaps = 78/219 (35%)

Query: 59  SCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMC---VPHCAD-KCV 114
           SCTD+ N + CT                       C PGFY  G++C      CAD  C 
Sbjct: 342 SCTDLENSYSCT-----------------------CPPGFY--GKICELSAMTCADGPCF 376

Query: 115 HG-RCI-APN---TCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGA--C 167
           +G RC  +P+   +C+C  G+ G NC    D      +C+S   C NGA C  +  A  C
Sbjct: 377 NGGRCSDSPDGGYSCRCPVGYSGFNCEKKID------YCSSS-PCSNGAKCVDLGDAYLC 429

Query: 168 HCAAGFRGWRCEDR-------------------------CEQGTYGNDCH---QRCQ--- 196
            C AGF G  C+D                          C  G  G +C     RC+   
Sbjct: 430 RCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP 489

Query: 197 CQNGATCDHVTGE---CRCPPGYTGAFCEDLCPPGKHGP 232
           C NGATC H  G    C C  GY G  C+ L P    GP
Sbjct: 490 CHNGATC-HERGHRYVCECARGYGGPNCQFLLPELPPGP 527


>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
          Length = 1590

 Score =  145 bits (365), Expect = 3e-34
 Identities = 110/342 (32%), Positives = 143/342 (41%), Gaps = 86/342 (25%)

Query: 93   QCCPGFYESG---EMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCT 149
            +C PG+  S     +C P C +   HG+CI PN CQC PG GG    + CD +H  P C 
Sbjct: 1315 KCKPGYIGSNCQTALCDPDCKN---HGKCIKPNICQCLPGHGG----ATCDEEHCNPPCQ 1367

Query: 150  SRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGE 209
                C  G LC        C  GF G RCE           C++   C+NG  C  +T +
Sbjct: 1368 HGGTCLAGNLCT-------CPYGFVGPRCETMV--------CNR--HCENGGQC--LTPD 1408

Query: 210  -CRCPPGYTGAFCED-LCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQP 267
             C+C PG+ G  C   LC P            C NGG C+     C CP+G+ G  C   
Sbjct: 1409 ICQCKPGWYGPTCSTALCDP-----------VCLNGGSCNK-PNTCLCPNGFFGEHC--- 1453

Query: 268  CPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCV 327
                   +N      C NGG C      C C  GYTG R Q          +C  T  C+
Sbjct: 1454 -------QNAFCHPPCKNGGHC-MRNNVCVCREGYTGRRFQKS--------ICDPT--CM 1495

Query: 328  NGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECAC 387
            NGGKC   S  C C +G++G+RC   +C +     KC     C   +          C C
Sbjct: 1496 NGGKCVGPS-TCSCPSGWSGKRCNTPICLQ-----KCKNGGECIAPSI---------CHC 1540

Query: 388  KPGWSGLYCN-ETCSPG-FYGEAC--QQICSCQ---NGADCD 422
               W G+ C    C+P   YG  C    +CSC+   +G  C+
Sbjct: 1541 PSSWEGVRCQIPICNPKCLYGGRCIFPNVCSCRTEYSGVKCE 1582



 Score =  122 bits (306), Expect = 2e-27
 Identities = 131/509 (25%), Positives = 166/509 (32%), Gaps = 153/509 (30%)

Query: 152  CQCKNGALC------NPITGA--CHCAAGFRGWRCE--------DRCEQGTYGNDCHQRC 195
            C C NG  C      +P +G   C C  GF G  CE        + C  G+Y +  H   
Sbjct: 1181 CDCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLGSYISGFHSY- 1239

Query: 196  QCQNGATCDHVTGECRCPPG------YTGAFCEDLCPPGKHGPQCEQRCPCQNG-GVCHH 248
                          C CPP       +   F        +      +    +N  G   H
Sbjct: 1240 -------------SCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRH 1286

Query: 249  VTGECSCPSGWMGTVCGQPCPEGR--------------FGKNCSQ---ECQCHNGGTCDA 291
            V       SG   T+C  PC + R               G NC     +  C N G C  
Sbjct: 1287 VKPT----SGNAFTICKYPCGKSRECVAPNICKCKPGYIGSNCQTALCDPDCKNHGKC-I 1341

Query: 292  ATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCE 351
                C C PG+ G  C +E         C   CQ  +GG C      C C  GF G RCE
Sbjct: 1342 KPNICQCLPGHGGATCDEEH--------CNPPCQ--HGGTCL-AGNLCTCPYGFVGPRCE 1390

Query: 352  ARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNET-CSPGFYGEACQ 410
              +C               H EN   C      C CKPGW G  C+   C P        
Sbjct: 1391 TMVCNR-------------HCENGGQCLTPD-ICQCKPGWYGPTCSTALCDP-------- 1428

Query: 411  QICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGS 470
                C NG  C+     C C  GF G  C           N      CKN   C   +  
Sbjct: 1429 ---VCLNGGSCNK-PNTCLCPNGFFGEHCQ----------NAFCHPPCKNGGHCMR-NNV 1473

Query: 471  CTCKAGWHG--VDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELP 528
            C C+ G+ G     SI  P+            C+NGG C     TC+C  GW G++C  P
Sbjct: 1474 CVCREGYTGRRFQKSICDPT------------CMNGGKC-VGPSTCSCPSGWSGKRCNTP 1520

Query: 529  CQDGTYGLNCAERC----DCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLP 584
                     C ++C    +C     CH       C   W GV C          P C+  
Sbjct: 1521 I--------CLQKCKNGGECIAPSICH-------CPSSWEGVRCQI--------PICNPK 1557

Query: 585  CYCKNGASCSPDDGICECAPGFRGTTCQR 613
            C    G    P+  +C C   + G  C++
Sbjct: 1558 C-LYGGRCIFPN--VCSCRTEYSGVKCEK 1583



 Score =  108 bits (271), Expect = 2e-23
 Identities = 122/477 (25%), Positives = 160/477 (33%), Gaps = 178/477 (37%)

Query: 306  RCQDECPVGTYGVL--CAETCQCVNGGKCYH------VSGA--CLCEAGFAGERCEARLC 355
            R  D+C   T   +    ++C C+NGG C         SG   C+C  GF G  CE  + 
Sbjct: 1161 RLNDDCDAETRVTIEVTVKSCDCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDIS 1220

Query: 356  P------------EGLYGIKCDKRCPCHLE------------------------------ 373
                          G +   CD  CP  L+                              
Sbjct: 1221 GCQSNPCGLGSYISGFHSYSCD--CPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDK 1278

Query: 374  ----NTHSCHPMSGE--------------------CACKPGWSGLYCNET---------- 399
                      P SG                     C CKPG+ G  C             
Sbjct: 1279 NAQGRKRHVKPTSGNAFTICKYPCGKSRECVAPNICKCKPGYIGSNCQTALCDPDCKNHG 1338

Query: 400  ---------CSPGFYGEAC-QQICS--CQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGT 447
                     C PG  G  C ++ C+  CQ+G  C      CTC  GF G  C T      
Sbjct: 1339 KCIKPNICQCLPGHGGATCDEEHCNPPCQHGGTC-LAGNLCTCPYGFVGPRCET------ 1391

Query: 448  YGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGAC 507
              + C+    C+N   C   D  C CK GW+G  CS           C+    CLNGG+C
Sbjct: 1392 --MVCNRH--CENGGQCLTPD-ICQCKPGWYGPTCSTAL--------CDPV--CLNGGSC 1436

Query: 508  NTLDGTCTCAPGWRGEKCE-----LPCQDGTYGLN-----CAER----------CD--CS 545
            N    TC C  G+ GE C+      PC++G + +      C E           CD  C 
Sbjct: 1437 NK-PNTCLCPNGFFGEHCQNAFCHPPCKNGGHCMRNNVCVCREGYTGRRFQKSICDPTCM 1495

Query: 546  HADGC-HPTTGHCRCLPGWSGVHCDS-VCAEGRWGPNCSLPCYCKNGASCSPDDGICECA 603
            +   C  P+T  C C  GWSG  C++ +C +            CKNG  C     IC C 
Sbjct: 1496 NGGKCVGPST--CSCPSGWSGKRCNTPICLQ-----------KCKNGGECIA-PSICHCP 1541

Query: 604  PGFRGTTCQ-RICSPG-FYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNE 658
              + G  CQ  IC+P   YG RC                   +C C   ++G  C +
Sbjct: 1542 SSWEGVRCQIPICNPKCLYGGRCI---------------FPNVCSCRTEYSGVKCEK 1583



 Score =  105 bits (263), Expect = 2e-22
 Identities = 122/469 (26%), Positives = 160/469 (34%), Gaps = 146/469 (31%)

Query: 407  EACQQICSCQNGADCDSVTG--------KCTCAPGFKGIDC--------STPCPLGTY-- 448
            E   + C C NG  C S            C C PGF G  C        S PC LG+Y  
Sbjct: 1175 EVTVKSCDCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLGSYIS 1234

Query: 449  GINCSSRCGCKND---------------AVCSPVDGSCTCKAGWHGVDCSIRCPSGTWG- 492
            G +  S C C  +                V +  D S   +          R    T G 
Sbjct: 1235 GFHSYS-CDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGN 1293

Query: 493  ------FGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSH 546
                  + C  + +C+           C C PG+ G  C+    D           DC +
Sbjct: 1294 AFTICKYPCGKSRECV-------APNICKCKPGYIGSNCQTALCDP----------DCKN 1336

Query: 547  ADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGF 606
               C      C+CLPG  G  CD          +C+ PC  ++G +C   + +C C  GF
Sbjct: 1337 HGKCIKPN-ICQCLPGHGGATCDE--------EHCNPPC--QHGGTCLAGN-LCTCPYGF 1384

Query: 607  RGTTCQRI-------------------CSPGFYGHRCSQT-CPQCVHSSGPCHHITGLCD 646
             G  C+ +                   C PG+YG  CS   C     + G C+     C 
Sbjct: 1385 VGPRCETMVCNRHCENGGQCLTPDICQCKPGWYGPTCSTALCDPVCLNGGSCNK-PNTCL 1443

Query: 647  CLPGFTG-----ALCNEVCPSG------------------RFGKNCAGIC--TCTNNGTC 681
            C  GF G     A C+  C +G                  RF K+   IC  TC N G C
Sbjct: 1444 CPNGFFGEHCQNAFCHPPCKNGGHCMRNNVCVCREGYTGRRFQKS---ICDPTCMNGGKC 1500

Query: 682  NPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLY 741
                 +C C  GW G  C+ P         C+    C NG  C A    C C   W G+ 
Sbjct: 1501 VG-PSTCSCPSGWSGKRCNTPI--------CLQ--KCKNGGECIA-PSICHCPSSWEGVR 1548

Query: 742  CTQRCPLGFYGKDCALIC--QCQNGADCDHISGQCTCRTGFMGRHCEQK 788
            C  + P          IC  +C  G  C      C+CRT + G  CE+K
Sbjct: 1549 C--QIP----------ICNPKCLYGGRC-IFPNVCSCRTEYSGVKCEKK 1584



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 99/377 (26%), Positives = 124/377 (32%), Gaps = 128/377 (33%)

Query: 542  CDCSHADGC------HPTTGH--CRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASC 593
            CDC +   C       P +G   C CLPG+ G  C+ V   G     C L  Y     S 
Sbjct: 1181 CDCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCE-VDISGCQSNPCGLGSYISGFHSY 1239

Query: 594  SPDDGICECAPGFRGTTC-------------------------------QRICSP--GFY 620
            S     C+C P  +  T                                +R   P  G  
Sbjct: 1240 S-----CDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNA 1294

Query: 621  GHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGIC--TCTNN 678
               C   C +      P      +C C PG+ G+ C               +C   C N+
Sbjct: 1295 FTICKYPCGKSRECVAP-----NICKCKPGYIGSNCQ------------TALCDPDCKNH 1337

Query: 679  GTCNPIDRSCQCYPGWIGSDCSQ-------------------PCPPAHWGPNC-IHTCN- 717
            G C      CQC PG  G+ C +                    CP    GP C    CN 
Sbjct: 1338 GKCIK-PNICQCLPGHGGATCDEEHCNPPCQHGGTCLAGNLCTCPYGFVGPRCETMVCNR 1396

Query: 718  -CHNGAFCSAYDGECKCTPGWTGLYC-------------------TQRCPLGFYGKDCA- 756
             C NG  C   D  C+C PGW G  C                   T  CP GF+G+ C  
Sbjct: 1397 HCENGGQCLTPD-ICQCKPGWYGPTCSTALCDPVCLNGGSCNKPNTCLCPNGFFGEHCQN 1455

Query: 757  LICQ--CQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICD--CLNNSTCDH 812
              C   C+NG  C   +  C CR G+ GR  +            + ICD  C+N   C  
Sbjct: 1456 AFCHPPCKNGGHCMR-NNVCVCREGYTGRRFQ------------KSICDPTCMNGGKCVG 1502

Query: 813  ITGTCYCSPGWKGARCD 829
               TC C  GW G RC+
Sbjct: 1503 -PSTCSCPSGWSGKRCN 1518



 Score = 73.9 bits (180), Expect = 8e-13
 Identities = 79/287 (27%), Positives = 99/287 (34%), Gaps = 83/287 (28%)

Query: 585  CYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPC---HHI 641
            C C NG SC  D      +PG     C  +C PGF+G  C      C   S PC    +I
Sbjct: 1181 CDCLNGGSCVSDRNF---SPGSGVYLC--VCLPGFHGSLCEVDISGC--QSNPCGLGSYI 1233

Query: 642  TGL----CDCLPG------FTGALCNEVCPSGRFGK-----------------------N 668
            +G     CDC P       F      +     R  K                       N
Sbjct: 1234 SGFHSYSCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGN 1293

Query: 669  CAGICT--CTNNGTCNPIDRSCQCYPGWIGSDCSQP-CPPAHWGPNCIHTCNCHNGAFCS 725
               IC   C  +  C      C+C PG+IGS+C    C P           +C N   C 
Sbjct: 1294 AFTICKYPCGKSREC-VAPNICKCKPGYIGSNCQTALCDP-----------DCKNHGKCI 1341

Query: 726  AYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQ-CTCRTGFMGRH 784
                 C+C PG  G  C +        + C     CQ+G  C  ++G  CTC  GF+G  
Sbjct: 1342 K-PNICQCLPGHGGATCDE--------EHCNP--PCQHGGTC--LAGNLCTCPYGFVGPR 1388

Query: 785  CEQKCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQA 831
            CE           C + C+  N   C      C C PGW G  C  A
Sbjct: 1389 CETMV--------CNRHCE--NGGQC-LTPDICQCKPGWYGPTCSTA 1424


>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
          Length = 1406

 Score =  145 bits (365), Expect = 3e-34
 Identities = 145/524 (27%), Positives = 203/524 (38%), Gaps = 145/524 (27%)

Query: 373 ENTHSCHPMS--GECACKPGWSGLY--CNETCSPGFYGEACQQICSCQNGADCDSVTGK- 427
           +N  +C   S   +C+C    + L   C+    P F          CQ  A C +  G+ 
Sbjct: 40  QNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNP-------CQGSATCVNTPGER 92

Query: 428 ---CTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVC--SPVDGSCTCKAGWHGVDC 482
              C C PG+ G  C T   +G+ G N      C++  +C   P+   C C AG+ G  C
Sbjct: 93  SFLCKCPPGYSGTICETT--IGSCGKN-----SCQHGGICHQDPIYPVCICPAGYAGRFC 145

Query: 483 SI---RCPSGTWGFGCNLTCQCLNGGACNT-LDG-TCTCAPGWRGEKCELPCQDGTYGLN 537
            I    C S            C NG  C   +DG +C C PG++G  C+L   +      
Sbjct: 146 EIDHDECASSP----------CQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDE------ 189

Query: 538 CAERCDCSHADGCHPTTGH--CRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSP 595
           CA    C +   C    G   C C   +SGV+C+    E    P       C NGA+C  
Sbjct: 190 CASD-PCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQP-------CLNGATCQD 241

Query: 596 DDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLC---------D 646
             G   C            C+PGF G  C     +C  +S PC H  GLC         +
Sbjct: 242 ALGAYFCD-----------CAPGFLGDHCELNTDEC--ASQPCLH-GGLCVDGENRYSCN 287

Query: 647 CL-PGFTGALCNEVCPSGRFGKNCAGIC---TCTNNGTC-NPIDR-SCQCYPGWIGSDC- 699
           C   GFTG  C  + P          +C    C NN TC + +D  +C C+PG+ G+ C 
Sbjct: 288 CTGSGFTGTHCETLMP----------LCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCE 337

Query: 700 -------SQPCPPAHWGPNCIHTCN----------CHNGAFCSAYDGECKCTPGWTGLYC 742
                  S PC        C+   +            + ++  A    C C PG+TG++C
Sbjct: 338 IDLNECNSNPCQS---NGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHC 394

Query: 743 TQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQIC 802
            +         +C+    CQNG  C+++ G  TC       HC     S T+ YG R   
Sbjct: 395 EEDV------NECSSN-PCQNGGTCENLPGNYTC-------HCPFDNLSRTF-YGGRDCS 439

Query: 803 D---------CLNNSTC-DHITG-----TCYCSPGWKGARCDQA 831
           D         CLNN TC  H        +C C  G+ G+ C+ A
Sbjct: 440 DILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIA 483



 Score =  143 bits (360), Expect = 1e-33
 Identities = 151/518 (29%), Positives = 202/518 (38%), Gaps = 114/518 (22%)

Query: 283 CHNGGTCDAATGQCHCSPGYTGERCQDECPV---GTYGVLCAETCQCVN--GGKCYHVSG 337
           C N  TC   +    CS   T      +C       +   C  +  CVN  G + +    
Sbjct: 39  CQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERSF---- 94

Query: 338 ACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYC- 396
            C C  G++G  CE  +   G     C     CH +      P+   C C  G++G +C 
Sbjct: 95  LCKCPPGYSGTICETTIGSCGKNS--CQHGGICHQD------PIYPVCICPAGYAGRFCE 146

Query: 397 --NETCSPGFYGEACQQICSCQNGADC-DSVTG-KCTCAPGFKGIDCSTPCPLGTYGINC 452
             ++ C+             CQNGA C D + G  C C PG++G  C            C
Sbjct: 147 IDHDECASS----------PCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVD------EC 190

Query: 453 SSRCGCKNDAVCSPVDG--SCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTL 510
           +S   CKN+A C    G  +C C   + GV+C +      W      +  CLNG  C   
Sbjct: 191 ASD-PCKNEATCLNEIGRYTCICPHNYSGVNCELEIDE-CW------SQPCLNGATCQDA 242

Query: 511 DGT--CTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGH--CRCL-PGWSG 565
            G   C CAPG+ G+ CEL   +      CA +  C H   C        C C   G++G
Sbjct: 243 LGAYFCDCAPGFLGDHCELNTDE------CASQ-PCLHGGLCVDGENRYSCNCTGSGFTG 295

Query: 566 VHCDSVCAEGRWGPNC-SLPCYCKNGASC--SPDDGICECAPGFRGTTCQRICSPGFYGH 622
            HC+++       P C S PC+  N A+C  S D+  C C PG+ G  C+ I       +
Sbjct: 296 THCETLM------PLCWSKPCH--NNATCEDSVDNYTCHCWPGYTGAQCE-IDLNECNSN 346

Query: 623 RCSQTCPQCVHSSGPCHH--ITGL-------------CDCLPGFTGALCNE---VCPSGR 664
            C Q+  +CV  S    +  ITGL             C C PGFTG  C E    C S  
Sbjct: 347 PC-QSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSS-- 403

Query: 665 FGKNCAGICTCTN---NGTCN-PIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHN 720
               C    TC N   N TC+ P D   + + G  G DCS           C H   C N
Sbjct: 404 --NPCQNGGTCENLPGNYTCHCPFDNLSRTFYG--GRDCSDIL------LGCTHQ-QCLN 452

Query: 721 GAFCSAY--DGE----CKCTPGWTGLYCTQRCPLGFYG 752
              C  +  DG+    C C  G+TG  C     L F G
Sbjct: 453 NGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSFEG 490



 Score =  142 bits (358), Expect = 2e-33
 Identities = 130/467 (27%), Positives = 172/467 (36%), Gaps = 143/467 (30%)

Query: 124 CQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALC--NPITGACHCAAGFRGWRCE-- 179
           C+C PG+ GT C +             +  C++G +C  +PI   C C AG+ G  CE  
Sbjct: 96  CKCPPGYSGTICETTIGS-------CGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEID 148

Query: 180 -DRCEQGTYGNDCHQRCQCQNGATC-DHVTG-ECRCPPGYTGAFCE---DLCPPGKHGPQ 233
            D C              CQNGA C D + G  C C PGY G  C+   D C        
Sbjct: 149 HDECASS----------PCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASD----- 193

Query: 234 CEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCS---QEC---QCHNGG 287
                PC+N   C +  G  +C            CP    G NC     EC    C NG 
Sbjct: 194 -----PCKNEATCLNEIGRYTC-----------ICPHNYSGVNCELEIDECWSQPCLNGA 237

Query: 288 TCDAATGQ--CHCSPGYTGERCQ---DECPVGTYGVLCAETCQCVNGGKCYHVSGACLCE 342
           TC  A G   C C+PG+ G+ C+   DEC           +  C++GG C        C 
Sbjct: 238 TCQDALGAYFCDCAPGFLGDHCELNTDEC----------ASQPCLHGGLCVDGENRYSCN 287

Query: 343 ---AGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCN-- 397
              +GF G  CE  L P       C  + PCH   T      +  C C PG++G  C   
Sbjct: 288 CTGSGFTGTHCET-LMP------LCWSK-PCHNNATCEDSVDNYTCHCWPGYTGAQCEID 339

Query: 398 -ETCSPGFYGEACQQICSCQNGADCDSVTGK----------------------CTCAPGF 434
              C+             CQ+  +C  ++ +                      C C PGF
Sbjct: 340 LNECNSN----------PCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGF 389

Query: 435 KGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTC--------KAGWHGVDCSIRC 486
            GI C          +N  S   C+N   C  + G+ TC        +  + G DCS   
Sbjct: 390 TGIHCEE-------DVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDIL 442

Query: 487 PSGTWGFGCNLTCQCLNGGAC--NTLDG----TCTCAPGWRGEKCEL 527
                  GC    QCLN G C  +  DG    +C C  G+ G  CE+
Sbjct: 443 ------LGCTHQ-QCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEI 482



 Score =  125 bits (315), Expect = 2e-28
 Identities = 126/439 (28%), Positives = 171/439 (38%), Gaps = 128/439 (29%)

Query: 95  CPGFYESGEMC-VPHCADKCVHGRCIAPNTCQ---------CEPGWGGTNCSSACDGDHW 144
           CP  Y +G  C + H  D+C    C     CQ         C PG+ G +C    D    
Sbjct: 136 CPAGY-AGRFCEIDH--DECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVD---- 188

Query: 145 GPHCTSRCQCKNGALCNPITG--ACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGAT 202
              C S   CKN A C    G   C C   + G  CE   +      +C  +  C NGAT
Sbjct: 189 --ECASD-PCKNEATCLNEIGRYTCICPHNYSGVNCELEID------ECWSQ-PCLNGAT 238

Query: 203 CDHVTGE--CRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGE----CSCP 256
           C    G   C C PG+ G  CE       +  +C  + PC +GG+C  V GE    C+C 
Sbjct: 239 CQDALGAYFCDCAPGFLGDHCE------LNTDECASQ-PCLHGGLC--VDGENRYSCNCT 289

Query: 257 -SGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQ--CHCSPGYTGERCQ---DE 310
            SG+ GT C    P             CHN  TC+ +     CHC PGYTG +C+   +E
Sbjct: 290 GSGFTGTHCETLMP-------LCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNE 342

Query: 311 CPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPC 370
           C           +  C + G+C  +S           E+   R+                
Sbjct: 343 C----------NSNPCQSNGECVELS----------SEKQYGRI---------------T 367

Query: 371 HLENTHSCHPMSG-ECACKPGWSGLYCNETCSPGFYGEACQQICS---CQNGADCDSVTG 426
            L ++ S H  SG  C C+PG++G++C E  +           CS   CQNG  C+++ G
Sbjct: 368 GLPSSFSYHEASGYVCICQPGFTGIHCEEDVNE----------CSSNPCQNGGTCENLPG 417

Query: 427 KCTCAPGFK--------GIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWH 478
             TC   F         G DCS         + C+ +  C N+  C P       + G H
Sbjct: 418 NYTCHCPFDNLSRTFYGGRDCSDIL------LGCTHQ-QCLNNGTCIP-----HFQDGQH 465

Query: 479 GVDCSIRCPSGTWGFGCNL 497
           G  C   CPSG  G  C +
Sbjct: 466 GFSC--LCPSGYTGSLCEI 482



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 72/219 (32%), Positives = 89/219 (40%), Gaps = 42/219 (19%)

Query: 154  CKNGALCNPITGACHCAA--GFRGWRCEDRCEQGTYGNDC-HQRCQCQNGATCDHVTGEC 210
            C +G  C  I  + HC+   G+ G  CE   ++  + N C H  C  +  A        C
Sbjct: 1148 CLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDE-CFSNPCIHGNCSDRVAAY------HC 1200

Query: 211  RCPPGYTGAFCE---DLCPPGKHGPQCEQRCPCQNGGVC-HHVTG-ECSCPSGWMGTVCG 265
             C PGYTG  CE   D C          Q   C NG  C  H  G  C C   + G  C 
Sbjct: 1201 TCEPGYTGVNCEVDIDNC----------QSHQCANGATCISHTNGYSCLCFGNFTGKFCR 1250

Query: 266  QPCPEGRFGKNCSQECQCHNGGTCDAATGQ--CHCSPGYTGERCQ---DECPVGTYGVLC 320
            Q         N      C+NGG C     +  C C PG+TGE C+   DEC         
Sbjct: 1251 QSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECA-------- 1302

Query: 321  AETCQCVNGGKCYHVSGA--CLCEAGFAGERCEARLCPE 357
              +  CVNGG C  +     CLC+  FAGERCE  L  +
Sbjct: 1303 --SDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLADD 1339



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 64/220 (29%), Positives = 86/220 (39%), Gaps = 53/220 (24%)

Query: 239  PCQNGGVCHHVTGE--CSCPSGWMGTVC--------GQPCPEGRFGKNCSQECQCHNGGT 288
            PC +GG C  +     CSCP GW G  C          PC  G    NCS     ++   
Sbjct: 1147 PCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHG----NCSDRVAAYH--- 1199

Query: 289  CDAATGQCHCSPGYTGERCQ---DECPVGTYGVLCAETCQCVNGGKCY-HVSG-ACLCEA 343
                   C C PGYTG  C+   D C          ++ QC NG  C  H +G +CLC  
Sbjct: 1200 -------CTCEPGYTGVNCEVDIDNC----------QSHQCANGATCISHTNGYSCLCFG 1242

Query: 344  GFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGE--CACKPGWSGLYCNETCS 401
             F G+ C     P  + G   +++      N  +C     E  C C+PG++G +C +   
Sbjct: 1243 NFTGKFCRQSRLPSTVCG---NEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDI- 1298

Query: 402  PGFYGEACQQICSCQNGADCDSVTGK--CTCAPGFKGIDC 439
                 + C     C NG  C  +  K  C C   F G  C
Sbjct: 1299 -----DECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERC 1332



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 58/173 (33%), Positives = 76/173 (43%), Gaps = 26/173 (15%)

Query: 103  EMCVPHC-ADKCVHGRC---IAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGA 158
            E+ +  C ++ C+HG C   +A   C CEPG+ G NC    D      +C S  QC NGA
Sbjct: 1175 ELNIDECFSNPCIHGNCSDRVAAYHCTCEPGYTGVNCEVDID------NCQSH-QCANGA 1227

Query: 159  LCNPITG--ACHCAAGFRGWRC-EDRCEQGTYGNDCHQRCQCQNGATCDHVTGE--CRCP 213
             C   T   +C C   F G  C + R      GN+      C NG  C     E  C C 
Sbjct: 1228 TCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNE-KTNLTCYNGGNCTEFQTELKCMCR 1286

Query: 214  PGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTG--ECSCPSGWMGTVC 264
            PG+TG +CE      K   +C    PC NGG+C  +    +C C   + G  C
Sbjct: 1287 PGFTGEWCE------KDIDECASD-PCVNGGLCQDLLNKFQCLCDVAFAGERC 1332



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 64/212 (30%), Positives = 79/212 (37%), Gaps = 36/212 (16%)

Query: 110  ADKCVHG-RC---IAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITG 165
            ++ C+HG  C    +   C C  GW G +C    D     P     C  +  A       
Sbjct: 1145 SNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAY------ 1198

Query: 166  ACHCAAGFRGWRCE---DRCEQGTYGNDCHQRCQCQNGATC-DHVTG-ECRCPPGYTGAF 220
             C C  G+ G  CE   D C          Q  QC NGATC  H  G  C C   +TG F
Sbjct: 1199 HCTCEPGYTGVNCEVDIDNC----------QSHQCANGATCISHTNGYSCLCFGNFTGKF 1248

Query: 221  CEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGE--CSCPSGWMGTVCGQPCPEGRFGKNCS 278
            C     P       +    C NGG C     E  C C  G+ G  C +   E      C+
Sbjct: 1249 CRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDE------CA 1302

Query: 279  QECQCHNGGTCDAATG--QCHCSPGYTGERCQ 308
             +  C NGG C       QC C   + GERC+
Sbjct: 1303 SD-PCVNGGLCQDLLNKFQCLCDVAFAGERCE 1333



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 60/206 (29%), Positives = 78/206 (37%), Gaps = 32/206 (15%)

Query: 599  ICECAPGFRGTTCQRI-------CSPGFYGHRCSQTCPQCVHSSGPCHH-------ITGL 644
            +C   P   G  C+ I       C  G+ G  C     +C   S PC H           
Sbjct: 1142 VCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECF--SNPCIHGNCSDRVAAYH 1199

Query: 645  CDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCP 704
            C C PG+TG  C EV         CA   TC ++        SC C+  + G  C Q   
Sbjct: 1200 CTCEPGYTGVNC-EVDIDNCQSHQCANGATCISHTN----GYSCLCFGNFTGKFCRQSRL 1254

Query: 705  PAHWGPNCIHTCNCHNGAFCSAYDGE--CKCTPGWTGLYCTQRCPLGFYGKDCALICQCQ 762
            P+    N      C+NG  C+ +  E  C C PG+TG +C +         +CA    C 
Sbjct: 1255 PSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDI------DECA-SDPCV 1307

Query: 763  NGADCDHISG--QCTCRTGFMGRHCE 786
            NG  C  +    QC C   F G  CE
Sbjct: 1308 NGGLCQDLLNKFQCLCDVAFAGERCE 1333



 Score = 73.9 bits (180), Expect = 8e-13
 Identities = 77/286 (26%), Positives = 120/286 (41%), Gaps = 64/286 (22%)

Query: 632  VHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCA-GICTCTNN----GTCNPIDR 686
            V +S PC H  G C+ +  ++   C+  CP G  GK+C   I  C +N    G C+  DR
Sbjct: 1142 VCNSNPCLH-GGNCEDI--YSSYHCS--CPLGWSGKHCELNIDECFSNPCIHGNCS--DR 1194

Query: 687  ----SCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDG--ECKCTPGWTGL 740
                 C C PG+ G +C           NC  +  C NGA C ++     C C   +TG 
Sbjct: 1195 VAAYHCTCEPGYTGVNCEVDID------NC-QSHQCANGATCISHTNGYSCLCFGNFTGK 1247

Query: 741  YCTQ-RCPLGFYGKDCALICQCQNGADCDHISGQ--CTCRTGFMGRHCEQ---KCPSGTY 794
            +C Q R P    G +   +  C NG +C     +  C CR GF G  CE+   +C S   
Sbjct: 1248 FCRQSRLPSTVCGNEKTNLT-CYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASD-- 1304

Query: 795  GYGCRQICDCLNNSTCDHITG--TCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPAD 852
                     C+N   C  +     C C   + G RC+   V +  +L S   T+      
Sbjct: 1305 --------PCVNGGLCQDLLNKFQCLCDVAFAGERCE---VDLADDLISDIFTT------ 1347

Query: 853  SYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPA 898
               IG++   ++L+L++  + ++    +   +G        TY+P+
Sbjct: 1348 ---IGSVTVALLLILLLAIVASVVTSNKRATQG--------TYSPS 1382



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 62/221 (28%), Positives = 79/221 (35%), Gaps = 34/221 (15%)

Query: 532  GTYGLNCAERCDCSHADGCHP--TTGHCRCLPGWSGVHCDSVCAEGRWGPNC-SLPCYCK 588
            G   LN      C H   C    ++ HC C  GWSG HC+    E      C S PC   
Sbjct: 1136 GCLQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDE------CFSNPCIHG 1189

Query: 589  NGASCSPDDGI--CECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCD 646
            N   CS       C C PG+ G  C+ +       H+C+       H++G        C 
Sbjct: 1190 N---CSDRVAAYHCTCEPGYTGVNCE-VDIDNCQSHQCANGATCISHTNGYS------CL 1239

Query: 647  CLPGFTGALCNEV-CPSGRFGKNCAGICTCTNNGTCNPI--DRSCQCYPGWIGSDCSQPC 703
            C   FTG  C +   PS   G     + TC N G C     +  C C PG+ G  C +  
Sbjct: 1240 CFGNFTGKFCRQSRLPSTVCGNEKTNL-TCYNGGNCTEFQTELKCMCRPGFTGEWCEKDI 1298

Query: 704  PPAHWGPNCIHTCNCHNGAFCS--AYDGECKCTPGWTGLYC 742
                  P       C NG  C       +C C   + G  C
Sbjct: 1299 DECASDP-------CVNGGLCQDLLNKFQCLCDVAFAGERC 1332



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 59/217 (27%), Positives = 84/217 (38%), Gaps = 37/217 (17%)

Query: 326  CVNGGKCYHVSGA--CLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSG 383
            C++GG C  +  +  C C  G++G+ CE  +        +C    PC +    S    + 
Sbjct: 1148 CLHGGNCEDIYSSYHCSCPLGWSGKHCELNID-------ECFSN-PC-IHGNCSDRVAAY 1198

Query: 384  ECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTG--KCTCAPGFKGIDCST 441
             C C+PG++G+ C          + CQ    C NGA C S T    C C   F G  C  
Sbjct: 1199 HCTCEPGYTGVNCEVDI------DNCQSH-QCANGATCISHTNGYSCLCFGNFTGKFCRQ 1251

Query: 442  PCPLGTYGINCSSRCGCKNDAVCSP--VDGSCTCKAGWHGVDCSI---RCPSGTWGFGCN 496
                 T   N  +   C N   C+    +  C C+ G+ G  C      C S        
Sbjct: 1252 SRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDP------ 1305

Query: 497  LTCQCLNGGACNTLDGT--CTCAPGWRGEKCELPCQD 531
                C+NGG C  L     C C   + GE+CE+   D
Sbjct: 1306 ----CVNGGLCQDLLNKFQCLCDVAFAGERCEVDLAD 1338



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 61/196 (31%), Positives = 76/196 (38%), Gaps = 30/196 (15%)

Query: 382  SGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCST 441
            S  C+C  GWSG +C       F        CS +  A        CTC PG+ G++C  
Sbjct: 1160 SYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAY------HCTCEPGYTGVNCEV 1213

Query: 442  PCPLGTYGINCSSRCGCKNDAVC-SPVDG-SCTCKAGWHGVDC-SIRCPSGTWG-FGCNL 497
                     NC S   C N A C S  +G SC C   + G  C   R PS   G    NL
Sbjct: 1214 DID------NCQSH-QCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNL 1266

Query: 498  TCQCLNGGACNTL--DGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTG 555
            T  C NGG C     +  C C PG+ GE CE    +      CA    C +   C     
Sbjct: 1267 T--CYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDE------CASD-PCVNGGLCQDLLN 1317

Query: 556  --HCRCLPGWSGVHCD 569
               C C   ++G  C+
Sbjct: 1318 KFQCLCDVAFAGERCE 1333



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 61/213 (28%), Positives = 79/213 (37%), Gaps = 53/213 (24%)

Query: 90  RKSQCCPGFYESGEMC---VPHCADKCVHGRCIAPN-----TCQCEPGWGGTNCSSACDG 141
           R S  C G   +G  C   +P C  K  H      +     TC C PG+ G  C    + 
Sbjct: 283 RYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNE 342

Query: 142 DHWGPHCTSRCQC---KNGALCNPITG-------------ACHCAAGFRGWRCEDRCEQG 185
            +  P C S  +C    +      ITG              C C  GF G  CE+     
Sbjct: 343 CNSNP-CQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDV--- 398

Query: 186 TYGNDCHQRCQCQNGATCDHVTGE--CRCP------PGYTGAFCEDLCPPGKHGPQCEQR 237
              N+C     CQNG TC+++ G   C CP        Y G  C D+     H       
Sbjct: 399 ---NECSSN-PCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQ------ 448

Query: 238 CPCQNGGVC--HHVTGE----CSCPSGWMGTVC 264
             C N G C  H   G+    C CPSG+ G++C
Sbjct: 449 -QCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLC 480



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 9/66 (13%)

Query: 239 PCQNGGVCHHVTGE--CSCPSGWMGTVCGQ-------PCPEGRFGKNCSQECQCHNGGTC 289
           PC NGGVCH    +  CSCP+   G  C +       PCP G   +   Q  +C      
Sbjct: 895 PCHNGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQPVLQGFECIANAVF 954

Query: 290 DAATGQ 295
           +  +GQ
Sbjct: 955 NGQSGQ 960



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 25/86 (29%), Positives = 32/86 (37%), Gaps = 18/86 (20%)

Query: 270 EGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAET-----C 324
           +G  G N  +   CHNGG C +      CS           CP  T G  C E       
Sbjct: 883 QGCAGDNSCKSNPCHNGGVCHSRWDDFSCS-----------CPALTSGKACEEVQWCGFS 931

Query: 325 QCVNGGKCYHV--SGACLCEAGFAGE 348
            C +G +C  V     C+  A F G+
Sbjct: 932 PCPHGAQCQPVLQGFECIANAVFNGQ 957


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.500 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,489,741
Number of Sequences: 37866
Number of extensions: 3513028
Number of successful extensions: 28614
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 448
Number of HSP's that attempted gapping in prelim test: 8465
Number of HSP's gapped (non-prelim): 5705
length of query: 1140
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1027
effective length of database: 13,968,660
effective search space: 14345813820
effective search space used: 14345813820
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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