Search of human proteins with 62177112

Search of human proteins with 62177112

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
         (490 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               985   0.0  
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               985   0.0  
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     638   0.0  
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]              268   8e-72
gi|31742536 fidgetin-like 1 [Homo sapiens]                            254   1e-67
gi|112789543 fidgetin-like 1 [Homo sapiens]                           254   1e-67
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]          253   4e-67
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]         246   3e-65
gi|40806170 spastin isoform 2 [Homo sapiens]                          240   2e-63
gi|11875211 spastin isoform 1 [Homo sapiens]                          240   2e-63
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     192   4e-49
gi|6005942 valosin-containing protein [Homo sapiens]                  189   6e-48
gi|64084766 fidgetin [Homo sapiens]                                   180   2e-45
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              173   3e-43
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 170   2e-42
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 170   2e-42
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       168   1e-41
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            167   3e-41
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     160   2e-39
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           159   5e-39
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            156   4e-38
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            156   4e-38
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           155   8e-38
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             151   1e-36
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                      145   1e-34
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                       145   1e-34
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   143   4e-34
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   143   4e-34
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   143   4e-34
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   141   1e-33

>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  985 bits (2546), Expect = 0.0
 Identities = 490/490 (100%), Positives = 490/490 (100%)

Query: 1   MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELL 60
           MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELL
Sbjct: 1   MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELL 60

Query: 61  EEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREV 120
           EEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREV
Sbjct: 61  EEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREV 120

Query: 121 RPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPK 180
           RPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPK
Sbjct: 121 RPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPK 180

Query: 181 FDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRP 240
           FDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRP
Sbjct: 181 FDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRP 240

Query: 241 WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYA 300
           WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYA
Sbjct: 241 WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYA 300

Query: 301 PTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNF 360
           PTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNF
Sbjct: 301 PTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNF 360

Query: 361 PWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADI 420
           PWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADI
Sbjct: 361 PWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADI 420

Query: 421 TNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKY 480
           TNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKY
Sbjct: 421 TNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKY 480

Query: 481 EKWMVEFGSA 490
           EKWMVEFGSA
Sbjct: 481 EKWMVEFGSA 490


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  985 bits (2546), Expect = 0.0
 Identities = 490/490 (100%), Positives = 490/490 (100%)

Query: 1   MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELL 60
           MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELL
Sbjct: 1   MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELL 60

Query: 61  EEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREV 120
           EEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREV
Sbjct: 61  EEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREV 120

Query: 121 RPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPK 180
           RPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPK
Sbjct: 121 RPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPK 180

Query: 181 FDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRP 240
           FDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRP
Sbjct: 181 FDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRP 240

Query: 241 WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYA 300
           WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYA
Sbjct: 241 WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYA 300

Query: 301 PTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNF 360
           PTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNF
Sbjct: 301 PTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNF 360

Query: 361 PWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADI 420
           PWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADI
Sbjct: 361 PWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADI 420

Query: 421 TNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKY 480
           TNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKY
Sbjct: 421 TNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKY 480

Query: 481 EKWMVEFGSA 490
           EKWMVEFGSA
Sbjct: 481 EKWMVEFGSA 490


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  638 bits (1646), Expect = 0.0
 Identities = 331/495 (66%), Positives = 383/495 (77%), Gaps = 11/495 (2%)

Query: 1   MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELL 60
           M+L  I +N K  REYALLGNYDS+MVYYQGV+ Q+ ++  SV+D  ++ KWQQV QE+ 
Sbjct: 1   MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEIN 60

Query: 61  EEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREV 120
            E + VK I+ TLESFK+D  P    +  D P  +  VW  PVP E R  P  R+  R+ 
Sbjct: 61  VEAKHVKDIMKTLESFKLDSTP-LKAAQHDLPASEGEVWSMPVPVERRPSPGPRK--RQS 117

Query: 121 RPLRKEMAGVGARGPVGRAHPISKSE------KPSTSRDKDYRARGRDDKGRKNMQDGAS 174
                  +         R H  S         K    R+K  + +GR++K +       +
Sbjct: 118 SQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPA--AVT 175

Query: 175 DGEMPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFF 234
           + E  KFD  GYDKDLVEALERDI+S+NP++ WDDIADL EAKKLL+EAVVLPMWMP+FF
Sbjct: 176 EPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFF 235

Query: 235 KGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFE 294
           KGIRRPWKGVLMVGPPGTGKT+LAKAVATEC TTFFNVSSSTLTSKYRGESEKLVRLLFE
Sbjct: 236 KGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFE 295

Query: 295 MARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMV 354
           MARFY+P TIFIDEIDSICSRRGTS+EHEASRRVK+ELL+QMDGVGG  ENDDPSKMVMV
Sbjct: 296 MARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMV 355

Query: 355 LAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEG 414
           LAATNFPWDIDEALRRRLEKRIYIPLP+AKGR ELL+I+LRE+EL  D+ L  IAE +EG
Sbjct: 356 LAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEG 415

Query: 415 YSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSA 474
           YSGADITNVCRDASLMAMRRRI GL+PEEIR LSKEE+ MP T  DFE+ALKK++KSVSA
Sbjct: 416 YSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSA 475

Query: 475 ADLEKYEKWMVEFGS 489
           AD+E+YEKW+ EFGS
Sbjct: 476 ADIERYEKWIFEFGS 490


>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score =  268 bits (685), Expect = 8e-72
 Identities = 144/314 (45%), Positives = 212/314 (67%), Gaps = 22/314 (7%)

Query: 188 KDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMV 247
           ++L   + RDI   NP+I W+DI  L+ AK+L++EAVV P+  P  F GI  PWKG+L+ 
Sbjct: 162 RELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLY 221

Query: 248 GPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFID 307
           GPPGTGKT+LAKAVATEC TTFFN+S+ST+ SK+RG+SEKLVR+LFE+AR++AP+TIF+D
Sbjct: 222 GPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLD 281

Query: 308 EIDSICSRRGTSD--EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365
           E++S+ S+RGT+   EHE S R+K+ELL+QMDG+  +        +V VLAA+N PW++D
Sbjct: 282 ELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARS------EDLVFVLAASNLPWELD 335

Query: 366 EALRRRLEKRIYIPLPTAKGRAELLKINL------REVELDPDIQLEDIAEKIEGYSGAD 419
            A+ RRLEKRI + LP+ + R  ++   L      R +EL  +++   ++++ EGYSG+D
Sbjct: 336 CAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSD 395

Query: 420 ITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMP-VTKGDFELAL---KKIAKSVSAA 475
           I  VCR+A++  +R+  + L   +  +     +Q+  VT  DF   L   K  AK+++  
Sbjct: 396 IKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLA-- 453

Query: 476 DLEKYEKWMVEFGS 489
             ++Y  W  EF S
Sbjct: 454 --QRYSDWQREFES 465


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  254 bits (650), Expect = 1e-67
 Identities = 136/301 (45%), Positives = 200/301 (66%), Gaps = 14/301 (4%)

Query: 190 LVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGP 249
           ++E +  +I+   P ++W+DIA +E AK  ++E VV PM  PD F G+R P KG+L+ GP
Sbjct: 383 MIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGP 442

Query: 250 PGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEI 309
           PGTGKT++ K +A++ G TFF++S+S+LTSK+ GE EK+VR LF +AR   P  IFIDEI
Sbjct: 443 PGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEI 502

Query: 310 DSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALR 369
           DS+ S+RG   EHE+SRR+K+E L+Q+DG   + E+      ++V+ ATN P +IDEA R
Sbjct: 503 DSLLSQRG-DGEHESSRRIKTEFLVQLDGATTSSED-----RILVVGATNRPQEIDEAAR 556

Query: 370 RRLEKRIYIPLPTAKGRAELLKINLREVE--LDPDIQLEDIAEKIEGYSGADITNVCRDA 427
           RRL KR+YIPLP A  R +++ INL   E     + ++E I ++ + +SGAD+T +CR+A
Sbjct: 557 RRLVKRLYIPLPEASARKQIV-INLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREA 615

Query: 428 SLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEF 487
           SL  +R     L   +I  ++ ++++ P+   DFE A + +  SVS  DLE YE W   F
Sbjct: 616 SLGPIR----SLQTADIATITPDQVR-PIAYIDFENAFRTVRPSVSPKDLELYENWNKTF 670

Query: 488 G 488
           G
Sbjct: 671 G 671


>gi|112789543 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  254 bits (650), Expect = 1e-67
 Identities = 136/301 (45%), Positives = 200/301 (66%), Gaps = 14/301 (4%)

Query: 190 LVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGP 249
           ++E +  +I+   P ++W+DIA +E AK  ++E VV PM  PD F G+R P KG+L+ GP
Sbjct: 383 MIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGP 442

Query: 250 PGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEI 309
           PGTGKT++ K +A++ G TFF++S+S+LTSK+ GE EK+VR LF +AR   P  IFIDEI
Sbjct: 443 PGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEI 502

Query: 310 DSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALR 369
           DS+ S+RG   EHE+SRR+K+E L+Q+DG   + E+      ++V+ ATN P +IDEA R
Sbjct: 503 DSLLSQRG-DGEHESSRRIKTEFLVQLDGATTSSED-----RILVVGATNRPQEIDEAAR 556

Query: 370 RRLEKRIYIPLPTAKGRAELLKINLREVE--LDPDIQLEDIAEKIEGYSGADITNVCRDA 427
           RRL KR+YIPLP A  R +++ INL   E     + ++E I ++ + +SGAD+T +CR+A
Sbjct: 557 RRLVKRLYIPLPEASARKQIV-INLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREA 615

Query: 428 SLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEF 487
           SL  +R     L   +I  ++ ++++ P+   DFE A + +  SVS  DLE YE W   F
Sbjct: 616 SLGPIR----SLQTADIATITPDQVR-PIAYIDFENAFRTVRPSVSPKDLELYENWNKTF 670

Query: 488 G 488
           G
Sbjct: 671 G 671


>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
          Length = 437

 Score =  253 bits (645), Expect = 4e-67
 Identities = 138/286 (48%), Positives = 193/286 (67%), Gaps = 13/286 (4%)

Query: 154 KDYRARGRDDKGRKNMQDGASDGEMPKFDGAGYD---KDLVEALERDIVSRNPSIHWDDI 210
           KDY  R ++  G+K +++  S+G+    D  G +   K L E L   +V   P+I W+D+
Sbjct: 71  KDY-LRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDV 129

Query: 211 ADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATEC-GTTF 269
           A LE AK+ L+EAV+LP+  P  F G R PW+G+L+ GPPGTGK+ LAKAVATE   +TF
Sbjct: 130 AGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTF 189

Query: 270 FNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVK 329
           F+VSSS L SK+ GESEKLV+ LFE+AR + P+ IFIDE+DS+C  R   +E EA+RR+K
Sbjct: 190 FSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR-NENESEAARRIK 248

Query: 330 SELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAEL 389
           +E L+QM GVG    N+D +   +VL ATN PW +D A+RRR EKRIYIPLP    RA++
Sbjct: 249 TEFLVQMQGVG---NNNDGT---LVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQM 302

Query: 390 LKINLREVELD-PDIQLEDIAEKIEGYSGADITNVCRDASLMAMRR 434
            +++L     +  D  + ++A K EGYSGADI+ + RD+ +  +R+
Sbjct: 303 FRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRK 348


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score =  246 bits (629), Expect = 3e-65
 Identities = 141/328 (42%), Positives = 203/328 (61%), Gaps = 24/328 (7%)

Query: 142 ISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSR 201
           +   EK +    K+ +    D+KG  N  DG  + + P+       K L   L+  IV  
Sbjct: 76  LKNKEKKAQKPVKEGQPSPADEKG--NDSDGEGESDDPE------KKKLQNQLQGAIVIE 127

Query: 202 NPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAV 261
            P++ W D+A LE AK+ L+EAV+LP+  P  F G R PW+G+L+ GPPGTGK+ LAKAV
Sbjct: 128 RPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAV 187

Query: 262 ATEC-GTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSD 320
           ATE   +TFF++SSS L SK+ GESEKLV+ LF++AR   P+ IFIDEIDS+C  R + +
Sbjct: 188 ATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR-SEN 246

Query: 321 EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPL 380
           E EA+RR+K+E L+QM GVG  ++ND     ++VL ATN PW +D A+RRR EKRIYIPL
Sbjct: 247 ESEAARRIKTEFLVQMQGVG--VDNDG----ILVLGATNIPWVLDSAIRRRFEKRIYIPL 300

Query: 381 PTAKGRAELLKINLREVELD-PDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGL 439
           P    RA + K++L   +    +    ++  K +GYSGADI+ + RDA +  +R+  +  
Sbjct: 301 PEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSAT 360

Query: 440 SPEEIRALSK-------EELQMPVTKGD 460
             +++R  S+       ++L  P + GD
Sbjct: 361 HFKKVRGPSRADPNHLVDDLLTPCSPGD 388


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  240 bits (612), Expect = 2e-63
 Identities = 141/305 (46%), Positives = 196/305 (64%), Gaps = 16/305 (5%)

Query: 187 DKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLM 246
           D +L   +  +IV    ++ +DDIA  + AK+ L+E V+LP   P+ F G+R P +G+L+
Sbjct: 289 DSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLL 348

Query: 247 VGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFI 306
            GPPG GKTMLAKAVA E   TFFN+S+++LTSKY GE EKLVR LF +AR   P+ IFI
Sbjct: 349 FGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFI 408

Query: 307 DEIDS-ICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365
           DE+DS +C RR    EH+ASRR+K+E LI+ DGV  A   DD    V+V+ ATN P ++D
Sbjct: 409 DEVDSLLCERR--EGEHDASRRLKTEFLIEFDGVQSA--GDD---RVLVMGATNRPQELD 461

Query: 366 EALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQ--LEDIAEKIEGYSGADITNV 423
           EA+ RR  KR+Y+ LP  + R  LLK NL   +  P  Q  L  +A   +GYSG+D+T +
Sbjct: 462 EAVLRRFIKRVYVSLPNEETRLLLLK-NLLCKQGSPLTQKELAQLARMTDGYSGSDLTAL 520

Query: 424 CRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKW 483
            +DA+L  +R     L PE+++ +S  E++  +   DF  +LKKI +SVS   LE Y +W
Sbjct: 521 AKDAALGPIRE----LKPEQVKNMSASEMR-NIRLSDFTESLKKIKRSVSPQTLEAYIRW 575

Query: 484 MVEFG 488
             +FG
Sbjct: 576 NKDFG 580


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score =  240 bits (612), Expect = 2e-63
 Identities = 141/305 (46%), Positives = 196/305 (64%), Gaps = 16/305 (5%)

Query: 187 DKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLM 246
           D +L   +  +IV    ++ +DDIA  + AK+ L+E V+LP   P+ F G+R P +G+L+
Sbjct: 321 DSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLL 380

Query: 247 VGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFI 306
            GPPG GKTMLAKAVA E   TFFN+S+++LTSKY GE EKLVR LF +AR   P+ IFI
Sbjct: 381 FGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFI 440

Query: 307 DEIDS-ICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365
           DE+DS +C RR    EH+ASRR+K+E LI+ DGV  A   DD    V+V+ ATN P ++D
Sbjct: 441 DEVDSLLCERR--EGEHDASRRLKTEFLIEFDGVQSA--GDD---RVLVMGATNRPQELD 493

Query: 366 EALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQ--LEDIAEKIEGYSGADITNV 423
           EA+ RR  KR+Y+ LP  + R  LLK NL   +  P  Q  L  +A   +GYSG+D+T +
Sbjct: 494 EAVLRRFIKRVYVSLPNEETRLLLLK-NLLCKQGSPLTQKELAQLARMTDGYSGSDLTAL 552

Query: 424 CRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKW 483
            +DA+L  +R     L PE+++ +S  E++  +   DF  +LKKI +SVS   LE Y +W
Sbjct: 553 AKDAALGPIRE----LKPEQVKNMSASEMR-NIRLSDFTESLKKIKRSVSPQTLEAYIRW 607

Query: 484 MVEFG 488
             +FG
Sbjct: 608 NKDFG 612


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  192 bits (489), Expect = 4e-49
 Identities = 109/276 (39%), Positives = 164/276 (59%), Gaps = 12/276 (4%)

Query: 202 NPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR--RPWKGVLMVGPPGTGKTMLAK 259
           N  + W DIA L++    L++ V+LP+     F+  R  +P KGVL+ GPPG GKT++AK
Sbjct: 85  NMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAK 144

Query: 260 AVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTS 319
           A A E G  F N+  STLT K+ GES+KL   +F +A    P+ IFIDEIDS    R +S
Sbjct: 145 ATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSS 204

Query: 320 DEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIP 379
           D HEA+  +K++ +   DG+     + D S  V+V+ ATN P D+D A+ RR+  R +I 
Sbjct: 205 D-HEATAMMKAQFMSLWDGL-----DTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHIN 258

Query: 380 LPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGL 439
            P  K R  +LK+ L+   +D  + L ++A++ +G+SG+D+  +CRDA+L+ +R  +N  
Sbjct: 259 QPALKQREAILKLILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNST 318

Query: 440 SPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAA 475
           S E       E+   PV + D   A++K+ KS  AA
Sbjct: 319 SEES----HDEDEIRPVQQQDLHRAIEKMKKSKDAA 350


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  189 bits (479), Expect = 6e-48
 Identities = 117/299 (39%), Positives = 168/299 (56%), Gaps = 20/299 (6%)

Query: 196 RDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPD-FFKGIRRPWKGVLMVGPPGTGK 254
           R+ V   P + W+DI  LE+ K+ L+E V  P+  PD F K    P KGVL  GPPG GK
Sbjct: 465 RETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGK 524

Query: 255 TMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICS 314
           T+LAKA+A EC   F ++    L + + GESE  VR +F+ AR  AP  +F DE+DSI  
Sbjct: 525 TLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAK 584

Query: 315 RRG--TSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR-- 370
            RG    D   A+ RV +++L +MDG+          K V ++ ATN P  ID A+ R  
Sbjct: 585 ARGGNIGDGGGAADRVINQILTEMDGM-------STKKNVFIIGATNRPDIIDPAILRPG 637

Query: 371 RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLM 430
           RL++ IYIPLP  K R  +LK NLR+  +  D+ LE +A+   G+SGAD+T +C+ A  +
Sbjct: 638 RLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKL 697

Query: 431 AMRRRING-LSPEEIRALSKEELQM-------PVTKGDFELALKKIAKSVSAADLEKYE 481
           A+R  I   +  E  R  +   +++        + +  FE A++   +SVS  D+ KYE
Sbjct: 698 AIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYE 756



 Score =  172 bits (435), Expect = 8e-43
 Identities = 102/266 (38%), Positives = 156/266 (58%), Gaps = 11/266 (4%)

Query: 205 IHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTMLAKAVAT 263
           + +DDI    +    ++E V LP+  P  FK I  +P +G+L+ GPPGTGKT++A+AVA 
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260

Query: 264 ECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHE 323
           E G  FF ++   + SK  GESE  +R  FE A   AP  IFIDE+D+I  +R      E
Sbjct: 261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR-EKTHGE 319

Query: 324 ASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLP 381
             RR+ S+LL  MDG+            V+V+AATN P  ID ALRR  R ++ + I +P
Sbjct: 320 VERRIVSQLLTLMDGL-------KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIP 372

Query: 382 TAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSP 441
            A GR E+L+I+ + ++L  D+ LE +A +  G+ GAD+  +C +A+L A+R++++ +  
Sbjct: 373 DATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDL 432

Query: 442 EEIRALSKEELQMPVTKGDFELALKK 467
           E+    ++    + VT  DF  AL +
Sbjct: 433 EDETIDAEVMNSLAVTMDDFRWALSQ 458


>gi|64084766 fidgetin [Homo sapiens]
          Length = 759

 Score =  180 bits (457), Expect = 2e-45
 Identities = 99/303 (32%), Positives = 180/303 (59%), Gaps = 12/303 (3%)

Query: 187 DKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLM 246
           D  L++ +  +I+++ P + W+DIA L+  K +++E V+ P+   D F G+    + +L+
Sbjct: 465 DTHLIDLVTNEIITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILL 524

Query: 247 VGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFI 306
            GP GTGKT+L + +A++ G TFF ++ S L +K+ GE+EK++   F +AR   P+ IF+
Sbjct: 525 FGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFV 584

Query: 307 DEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDE 366
            +ID + S +  ++EH    R+++E L+Q+D V  + E+      ++V+ AT+ P +IDE
Sbjct: 585 SDIDMLLSSQ-VNEEHSPVSRMRTEFLMQLDTVLTSAED-----QIVVICATSKPEEIDE 638

Query: 367 ALRRRLEKRIYIPLPTAKGRAELLKINLREVELD-PDIQLEDIAEKIEGYSGADITNVCR 425
           +LRR   KR+ IPLP +  R +++   L +      D +   + ++ EG+SG D+ ++C+
Sbjct: 639 SLRRYFMKRLLIPLPDSTARHQIIVQLLSQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQ 698

Query: 426 DASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMV 485
           +A +      ++ +   ++ A+   +L+ PVT  DFE A  KI  S+S  +L+ Y +W  
Sbjct: 699 EAVV----GPLHAMPATDLSAIMPSQLR-PVTYQDFENAFCKIQPSISQKELDMYVEWNK 753

Query: 486 EFG 488
            FG
Sbjct: 754 MFG 756


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  173 bits (439), Expect = 3e-43
 Identities = 102/253 (40%), Positives = 150/253 (59%), Gaps = 13/253 (5%)

Query: 189 DLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFF--KGIRRPWKGVLM 246
           D+  +  R+I    P++ W DI  LE  K  L +AV  P+  P+ F   GI+ P KGVL+
Sbjct: 608 DIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPP-KGVLL 666

Query: 247 VGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFI 306
            GPPG  KTM+AKA+A E G  F  +    L +KY GESE+ VR  F  AR  AP+ IF 
Sbjct: 667 YGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFF 726

Query: 307 DEIDSICSRRGTS-DEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365
           DE+D++   RG+S      + RV ++LL +MDG+       +  K V +LAATN P  ID
Sbjct: 727 DELDALAVERGSSLGAGNVADRVLAQLLTEMDGI-------EQLKDVTILAATNRPDRID 779

Query: 366 EALRR--RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNV 423
           +AL R  R+++ IY+PLP A  R E+ K+    + +  ++ L+++  + + YSGA+I  V
Sbjct: 780 KALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAV 839

Query: 424 CRDASLMAMRRRI 436
           CR+A+L+A+   I
Sbjct: 840 CREAALLALEEDI 852



 Score =  155 bits (392), Expect = 8e-38
 Identities = 95/235 (40%), Positives = 138/235 (58%), Gaps = 11/235 (4%)

Query: 205 IHWDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKAVA 262
           + +D I  L    K +RE + LP+  P+ FK  GI  P +GVL+ GPPGTGKTM+A+AVA
Sbjct: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAP-RGVLLYGPPGTGKTMIARAVA 408

Query: 263 TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEH 322
            E G     ++   + SK+ GE+E  +R +F  A    P+ IFIDE+D++C +R    ++
Sbjct: 409 NEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR-EGAQN 467

Query: 323 EASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPL 380
           E  +RV + LL  MDG+G  +        V+VL ATN P  +D ALRR  R +K I I +
Sbjct: 468 EVEKRVVASLLTLMDGIGSEVSEG----QVLVLGATNRPHALDAALRRPGRFDKEIEIGV 523

Query: 381 PTAKGRAELLKINLREV-ELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRR 434
           P A+ R ++L+  LR V  L  + +L  +A    GY GAD+  +C +A L A+RR
Sbjct: 524 PNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRR 578


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  170 bits (431), Expect = 2e-42
 Identities = 112/289 (38%), Positives = 168/289 (58%), Gaps = 24/289 (8%)

Query: 203 PSIHWDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKA 260
           P++ W DI  LE+ ++ L  A++ P+  PD FK  G+  P  GVL+ GPPG GKT+LAKA
Sbjct: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGKTLLAKA 528

Query: 261 VATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSD 320
           VA E G  F +V    L + Y GESE+ VR +F+ A+  AP  IF DE+D++C RR +  
Sbjct: 529 VANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRR-SDR 587

Query: 321 EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 378
           E  AS RV ++LL +MDG+       +  + V ++AATN P  ID A+ R  RL+K +++
Sbjct: 588 ETGASVRVVNQLLTEMDGL-------EARQQVFIMAATNRPDIIDPAILRPGRLDKTLFV 640

Query: 379 PLPTAKGRAELLKI---NLREVELDPDIQLEDIAE--KIEGYSGADITNVCRDASLMAMR 433
            LP    R  +LK    N  +  LD D+ LE IA   + + Y+GAD++ + R+AS+ A+R
Sbjct: 641 GLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALR 700

Query: 434 RRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEK 482
           + +        +    E+ ++ V+   FE A KK+  S+S  D   YE+
Sbjct: 701 QEM------ARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 743



 Score =  123 bits (308), Expect = 4e-28
 Identities = 95/317 (29%), Positives = 163/317 (51%), Gaps = 23/317 (7%)

Query: 144 KSEKPSTSRDKDYRARGR-DDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSRN 202
           +  K S+  + D + +G+  +KG K  ++     ++ + DG        +A  R +  + 
Sbjct: 99  QDSKDSSLLESDMKRKGKLKNKGSKRKKE-----DLQEVDGEIEAVLQKKAKARGLEFQI 153

Query: 203 PSIHWDDIAD----LEEAKKLLREAVVLPMWMPDFFKGIRR-PWKGVLMVGPPGTGKTML 257
            ++ ++D+      L+E  K+L     + M  P+ +  +   P +GVL+ GPPG GKT+L
Sbjct: 154 SNVKFEDVGGNDMTLKEVCKML-----IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLL 208

Query: 258 AKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRG 317
           A A+A E       V++  + S   GESE+ +R LFE A   AP  IFIDEID+I  +R 
Sbjct: 209 AHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKRE 268

Query: 318 TSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKR 375
            + + +  RR+ ++LL  MD     L N   +  V+V+ ATN P  +D ALRR  R ++ 
Sbjct: 269 VASK-DMERRIVAQLLTCMDD----LNNVAATARVLVIGATNRPDSLDPALRRAGRFDRE 323

Query: 376 IYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRR 435
           I + +P    R  +L+   R++ L        +A    G+ GAD+  +CR+A++ A+ R 
Sbjct: 324 ICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRV 383

Query: 436 INGLSPEEIRALSKEEL 452
           +  L  ++ +    E+L
Sbjct: 384 LMKLQEQQKKNPEMEDL 400


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  170 bits (431), Expect = 2e-42
 Identities = 112/289 (38%), Positives = 168/289 (58%), Gaps = 24/289 (8%)

Query: 203 PSIHWDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKA 260
           P++ W DI  LE+ ++ L  A++ P+  PD FK  G+  P  GVL+ GPPG GKT+LAKA
Sbjct: 576 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGKTLLAKA 634

Query: 261 VATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSD 320
           VA E G  F +V    L + Y GESE+ VR +F+ A+  AP  IF DE+D++C RR +  
Sbjct: 635 VANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRR-SDR 693

Query: 321 EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 378
           E  AS RV ++LL +MDG+       +  + V ++AATN P  ID A+ R  RL+K +++
Sbjct: 694 ETGASVRVVNQLLTEMDGL-------EARQQVFIMAATNRPDIIDPAILRPGRLDKTLFV 746

Query: 379 PLPTAKGRAELLKI---NLREVELDPDIQLEDIAE--KIEGYSGADITNVCRDASLMAMR 433
            LP    R  +LK    N  +  LD D+ LE IA   + + Y+GAD++ + R+AS+ A+R
Sbjct: 747 GLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALR 806

Query: 434 RRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEK 482
           + +        +    E+ ++ V+   FE A KK+  S+S  D   YE+
Sbjct: 807 QEM------ARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 849



 Score =  123 bits (308), Expect = 4e-28
 Identities = 95/317 (29%), Positives = 163/317 (51%), Gaps = 23/317 (7%)

Query: 144 KSEKPSTSRDKDYRARGR-DDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSRN 202
           +  K S+  + D + +G+  +KG K  ++     ++ + DG        +A  R +  + 
Sbjct: 205 QDSKDSSLLESDMKRKGKLKNKGSKRKKE-----DLQEVDGEIEAVLQKKAKARGLEFQI 259

Query: 203 PSIHWDDIAD----LEEAKKLLREAVVLPMWMPDFFKGIRR-PWKGVLMVGPPGTGKTML 257
            ++ ++D+      L+E  K+L     + M  P+ +  +   P +GVL+ GPPG GKT+L
Sbjct: 260 SNVKFEDVGGNDMTLKEVCKML-----IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLL 314

Query: 258 AKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRG 317
           A A+A E       V++  + S   GESE+ +R LFE A   AP  IFIDEID+I  +R 
Sbjct: 315 AHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKRE 374

Query: 318 TSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKR 375
            + + +  RR+ ++LL  MD     L N   +  V+V+ ATN P  +D ALRR  R ++ 
Sbjct: 375 VASK-DMERRIVAQLLTCMDD----LNNVAATARVLVIGATNRPDSLDPALRRAGRFDRE 429

Query: 376 IYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRR 435
           I + +P    R  +L+   R++ L        +A    G+ GAD+  +CR+A++ A+ R 
Sbjct: 430 ICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRV 489

Query: 436 INGLSPEEIRALSKEEL 452
           +  L  ++ +    E+L
Sbjct: 490 LMKLQEQQKKNPEMEDL 506


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  168 bits (425), Expect = 1e-41
 Identities = 108/294 (36%), Positives = 166/294 (56%), Gaps = 32/294 (10%)

Query: 205 IHWDDIADLEEAKKLLREAVVLPMWMPDFF--KGIRRPWKGVLMVGPPGTGKTMLAKAVA 262
           + W++I  LE+ K  L++++  P+  P  F   G+ +P KGVL+ GPPG  KT L +A+A
Sbjct: 461 VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQP-KGVLLYGPPGCAKTTLVRALA 519

Query: 263 TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEH 322
           T C  +F +VS + L S + G+SEK++  +F  AR   P  +F+DEIDSI   R  S   
Sbjct: 520 TSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTG 579

Query: 323 -EASRRVKSELLIQMDGVG-------GALENDDP-----SKMVMVLAATNFPWDIDEALR 369
            +   RV S LL ++DGVG       G+  +        ++ VM++AATN P  +D AL 
Sbjct: 580 CDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALL 639

Query: 370 R--RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDA 427
           R  RL+K IYIP P  KGR  +LK+  + + + PD+ LE++A +   +SGAD+ N+C +A
Sbjct: 640 RPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEA 699

Query: 428 SLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYE 481
           +L+A++   NGL    ++            +  F  +LK +  S+S  DL  YE
Sbjct: 700 ALLALQE--NGLDATTVK------------QEHFLKSLKTVKPSLSCKDLALYE 739



 Score =  134 bits (336), Expect = 2e-31
 Identities = 86/230 (37%), Positives = 130/230 (56%), Gaps = 18/230 (7%)

Query: 210 IADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKAVATECGT 267
           +  L EA   LRE + LP+  P      G+  P +GVL+ GPPG GKT L +AVA E G 
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVP-RGVLLAGPPGVGKTQLVRAVAREAGA 260

Query: 268 TFFNVSSSTLTSKYRGESEKLVRLLFEMARFYA---PTTIFIDEIDSICSRRGTSDEHEA 324
               VS+  L     GE+E+ VR +F+ AR  A   P+ +F+DE+D++C +RG+      
Sbjct: 261 ELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGS---RAP 317

Query: 325 SRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPT 382
             RV +++L  +DG  G  E       V+V+ ATN P  +D ALRR  R ++ + I  PT
Sbjct: 318 ESRVVAQVLTLLDGASGDRE-------VVVVGATNRPDALDPALRRPGRFDREVVIGTPT 370

Query: 383 AKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAM 432
            K R E+L++   ++ +   + L  +AE   GY GAD+T +CR+A++ A+
Sbjct: 371 LKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  167 bits (422), Expect = 3e-41
 Identities = 110/292 (37%), Positives = 165/292 (56%), Gaps = 31/292 (10%)

Query: 198 IVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKT 255
           +V + P   ++ I  L++  K ++E + LP+  P+ F+  GI +P KGVL+ GPPGTGKT
Sbjct: 139 MVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQP-KGVLLYGPPGTGKT 197

Query: 256 MLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSR 315
           +LA+AVA     TF  VS S L  K+ GE  ++VR LF MAR +AP+ IF+DEIDSI S 
Sbjct: 198 LLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSS 257

Query: 316 R--GTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--R 371
           R  G S      +R   ELL Q+DG        + +K + V+ ATN    +D AL R  R
Sbjct: 258 RLEGGSGGDSEVQRTMLELLNQLDGF-------EATKNIKVIMATNRIDILDSALLRPGR 310

Query: 372 LEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMA 431
           ++++I  P P  + R ++LKI+ R++ L   I L  IAE + G SGA++  VC +A + A
Sbjct: 311 IDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYA 370

Query: 432 MRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKW 483
           +R R                 ++ VT+ DFE+A+ K+ +  S  ++   + W
Sbjct: 371 LRER-----------------RVHVTQEDFEMAVAKVMQKDSEKNMSIKKLW 405


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  160 bits (405), Expect = 2e-39
 Identities = 127/389 (32%), Positives = 197/389 (50%), Gaps = 43/389 (11%)

Query: 107 HRAPPQI--RRPNREVRPLRKEMAGVGARGPV-----GRAHPISKSEKPSTSRDKDYRAR 159
           H+  P I    P    RP R  ++  G R P       R H I  S+  S+S  +D +  
Sbjct: 314 HQRKPNIFYSGPASPARP-RYRLSSAGPRSPYCKRMNRRRHAIHSSDSTSSSSSEDEQ-- 370

Query: 160 GRDDKGRKNMQDGASDGEMP----KFDGAGYDKDLVEA----LERDIVSRNPSIHWDDIA 211
              ++ RK  ++ A +  +P    K +  G  KD ++      + D +  + S+ +D + 
Sbjct: 371 -HFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVG 429

Query: 212 DLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTMLAKAVATECG---- 266
            L      L+E VV P+  P+ F+  + +P +G L  GPPGTGKT++A+A+A EC     
Sbjct: 430 GLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDK 489

Query: 267 -TTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEAS 325
              FF    +   SK+ GESE+ +RLLF+ A    P+ IF DEID +   R +S + +  
Sbjct: 490 RVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR-SSRQDQIH 548

Query: 326 RRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPTA 383
             + S LL  MDG+       D    ++V+ ATN    ID ALRR  R ++     LP  
Sbjct: 549 SSIVSTLLALMDGL-------DSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDK 601

Query: 384 KGRAELLKINLREVELDP-DIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPE 442
           + R E+LKI+ R+    P D  LE++AE   GY GADI ++C +A+L A+RRR     P+
Sbjct: 602 EARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRY----PQ 657

Query: 443 EIRALSKEELQMP---VTKGDFELALKKI 468
                 K +L +    ++  DFE+A++K+
Sbjct: 658 IYTTSEKLQLDLSSINISAKDFEVAMQKM 686


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  159 bits (402), Expect = 5e-39
 Identities = 96/236 (40%), Positives = 142/236 (60%), Gaps = 14/236 (5%)

Query: 204 SIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRR-PWKGVLMVGPPGTGKTMLAKAVA 262
           ++ + +I  L E  + LRE + LP+  P+ F+ +   P KG L+ GPPGTGKT+LA+AVA
Sbjct: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202

Query: 263 TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR---GTS 319
           ++    F  V SS++  KY GES +L+R +F  AR + P  IF+DEID+I  RR   GTS
Sbjct: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262

Query: 320 DEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIY 377
            + E  R +  ELL QMDG        D    V ++ ATN P  +D AL R  RL+++I+
Sbjct: 263 ADREIQRTL-MELLNQMDGF-------DTLHRVKMIMATNRPDTLDPALLRPGRLDRKIH 314

Query: 378 IPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMR 433
           I LP  + R ++LKI+   +    +I  E I +  +G++GAD+ NVC +A + A+R
Sbjct: 315 IDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIR 370


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  156 bits (395), Expect = 4e-38
 Identities = 101/275 (36%), Positives = 159/275 (57%), Gaps = 22/275 (8%)

Query: 191 VEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGP 249
           V+A+E   V   P+  + DI  L++  + L EA+VLPM   + F+ +  +P KGVLM GP
Sbjct: 172 VKAME---VDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGP 228

Query: 250 PGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEI 309
           PGTGKT+LA+A A +   TF  ++   L   + G+  KLVR  F +A+  AP+ IFIDE+
Sbjct: 229 PGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDEL 288

Query: 310 DSICSRRGTSDE--HEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEA 367
           D+I ++R  S++      +R   ELL Q+DG         P+  V V+AATN    +D A
Sbjct: 289 DAIGTKRFDSEKAGDREVQRTMLELLNQLDGF-------QPNTQVKVIAATNRVDILDPA 341

Query: 368 LRR--RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCR 425
           L R  RL+++I  P+P  + RA +++I+ R++ + PD+  E++A   + ++GA    VC 
Sbjct: 342 LLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCV 401

Query: 426 DASLMAMRRRINGLSPE-------EIRALSKEELQ 453
           +A ++A+RR    L+ E       E++A  K  LQ
Sbjct: 402 EAGMIALRRGATELTHEDYMEGILEVQAKKKANLQ 436


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  156 bits (395), Expect = 4e-38
 Identities = 100/260 (38%), Positives = 150/260 (57%), Gaps = 15/260 (5%)

Query: 199 VSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTM 256
           V + P   + DI  L+   + ++E+V LP+  P++++  GI+ P KGV++ GPPGTGKT+
Sbjct: 176 VEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPP-KGVILYGPPGTGKTL 234

Query: 257 LAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR 316
           LAKAVA +   TF  V  S L  KY G+  KLVR LF +A  +AP+ +FIDEID+I ++R
Sbjct: 235 LAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKR 294

Query: 317 --GTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RL 372
               S      +R   ELL Q+DG        D    V V+ ATN    +D AL R  R+
Sbjct: 295 YDSNSGGEREIQRTMLELLNQLDGF-------DSRGDVKVIMATNRIETLDPALIRPGRI 347

Query: 373 EKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAM 432
           +++I  PLP  K +  + +I+   + L  D+ L+D+    +  SGADI  +C +A LMA+
Sbjct: 348 DRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMAL 407

Query: 433 RRRINGLSPEEIRALSKEEL 452
           R R   ++ E+ +  SKE +
Sbjct: 408 RERRMKVTNEDFKK-SKENV 426


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  155 bits (392), Expect = 8e-38
 Identities = 103/293 (35%), Positives = 160/293 (54%), Gaps = 19/293 (6%)

Query: 203 PSIHWDDIADLEEAKKLLREAVVLPMWMPDFFK-GIRRPWKGVLMVGPPGTGKTMLAKAV 261
           PS+ W D+  L+E KK + E + LP+  P+    G+RR   G+L+ GPPGTGKT+LAKAV
Sbjct: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRR--SGLLLHGPPGTGKTLLAKAV 757

Query: 262 ATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTS-D 320
           ATEC  TF +V    L + Y G+SE+ VR +F  AR  AP  IF DE+DS+   RG S D
Sbjct: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGD 817

Query: 321 EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 378
                 RV S+LL ++DG+    +       V V+ ATN P  +D AL R  R +K +++
Sbjct: 818 SGGVMDRVVSQLLAELDGLHSTQD-------VFVIGATNRPDLLDPALLRPGRFDKLVFV 870

Query: 379 PLPTAK-GRAELLKINLREVELDPDIQLEDIAEKI-EGYSGADITNVCRDASLMAMRRRI 436
                +  +  +L    R+ +L+P + L ++ +      +GAD+ ++C DA   A++RR+
Sbjct: 871 GANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRV 930

Query: 437 NGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEFGS 489
           + L       L      + +T  D   A  ++  SVS  +L +Y++   +F +
Sbjct: 931 HDLE----EGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAA 979



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 60/239 (25%), Positives = 98/239 (41%), Gaps = 18/239 (7%)

Query: 244 VLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTT 303
           VL+ GPPG GKT +  A  +  G     V  S+L ++  G  E  ++ +F  AR   P  
Sbjct: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525

Query: 304 IFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLA--ATNFP 361
           + +  +D +   R    E      V   LL+  D +     N  P  MV+     A + P
Sbjct: 526 LLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPL-----NSCPPLMVVATTSRAQDLP 580

Query: 362 WDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADIT 421
            D+  A    LE    +P  +   R  +L+     + L  ++ L  +A +  G+   D+ 
Sbjct: 581 ADVQTAFPHELE----VPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLY 636

Query: 422 NVCRDASLMAMRRRIN-----GLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAA 475
            +   +S  A  R  N     GL+ E+   L       P+   DF  AL+++  + S A
Sbjct: 637 ALLTHSSRAACTRIKNSGLAGGLTEEDEGELC--AAGFPLLAEDFGQALEQLQTAHSQA 693


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  151 bits (381), Expect = 1e-36
 Identities = 95/243 (39%), Positives = 133/243 (54%), Gaps = 14/243 (5%)

Query: 199 VSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTML 257
           V   P + + D+   +E  + LRE V  P+  P+ F  +   P KGVL+ GPPGTGKT+ 
Sbjct: 166 VEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLC 225

Query: 258 AKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR- 316
           A+AVA      F  V  S L  KY GE  ++VR LFEMAR      IF DEID+I   R 
Sbjct: 226 ARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARF 285

Query: 317 --GTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RL 372
             G   ++E  +R   EL+ Q+DG        DP   + VL ATN P  +D AL R  RL
Sbjct: 286 DDGAGGDNEV-QRTMLELINQLDGF-------DPRGNIKVLMATNRPDTLDPALMRPGRL 337

Query: 373 EKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAM 432
           +++I   LP  +GR  + KI+ R + ++ DI+ E +A      +GA+I +VC +A + A+
Sbjct: 338 DRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAI 397

Query: 433 RRR 435
           R R
Sbjct: 398 RAR 400


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score =  145 bits (365), Expect = 1e-34
 Identities = 97/275 (35%), Positives = 154/275 (56%), Gaps = 16/275 (5%)

Query: 204 SIHWDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKAV 261
           ++ ++ +  +EEAK+ L+E V   +  P  F   G + P KG+L+VGPPGTGKT+LA+AV
Sbjct: 335 NVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLP-KGILLVGPPGTGKTLLARAV 392

Query: 262 ATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDE 321
           A E    F+  S S     + G     +R LF  A+  AP  IFIDE+DS+  +R  S  
Sbjct: 393 AGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPM 452

Query: 322 HEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIP 379
           H  SR+  ++LL +MDG         P++ V+++ ATNFP  +D AL R  R + ++ +P
Sbjct: 453 HPYSRQTINQLLAEMDGF-------KPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVP 505

Query: 380 LPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGL 439
            P  KGR E+LK  L +++ D  +  E IA    G+SGA++ N+   A+L A       +
Sbjct: 506 RPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMV 565

Query: 440 SPEEIRALSKEELQMPVTKGDFELALKKIAKSVSA 474
           + +E+   SK+++ M   +   E+  K   K+++A
Sbjct: 566 TMKELE-FSKDKILMGPERRSVEIDNKN--KTITA 597


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score =  145 bits (365), Expect = 1e-34
 Identities = 97/275 (35%), Positives = 154/275 (56%), Gaps = 16/275 (5%)

Query: 204 SIHWDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKAV 261
           ++ ++ +  +EEAK+ L+E V   +  P  F   G + P KG+L+VGPPGTGKT+LA+AV
Sbjct: 278 NVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLP-KGILLVGPPGTGKTLLARAV 335

Query: 262 ATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDE 321
           A E    F+  S S     + G     +R LF  A+  AP  IFIDE+DS+  +R  S  
Sbjct: 336 AGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPM 395

Query: 322 HEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIP 379
           H  SR+  ++LL +MDG         P++ V+++ ATNFP  +D AL R  R + ++ +P
Sbjct: 396 HPYSRQTINQLLAEMDGF-------KPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVP 448

Query: 380 LPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGL 439
            P  KGR E+LK  L +++ D  +  E IA    G+SGA++ N+   A+L A       +
Sbjct: 449 RPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMV 508

Query: 440 SPEEIRALSKEELQMPVTKGDFELALKKIAKSVSA 474
           + +E+   SK+++ M   +   E+  K   K+++A
Sbjct: 509 TMKELE-FSKDKILMGPERRSVEIDNKN--KTITA 540


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  143 bits (360), Expect = 4e-34
 Identities = 91/239 (38%), Positives = 136/239 (56%), Gaps = 14/239 (5%)

Query: 201 RNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTMLAK 259
           + P + + DI  ++  K+ +REAV LP+   + +K I   P +GVLM GPPG GKTMLAK
Sbjct: 154 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 213

Query: 260 AVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR--- 316
           AVA      F  V  S    KY GE  ++VR +F +A+  AP  IFIDEID+I ++R   
Sbjct: 214 AVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDA 273

Query: 317 GTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEK 374
            T  + E  +R+  ELL QMDG        D +  V V+ ATN    +D AL R  RL++
Sbjct: 274 QTGADREV-QRILLELLNQMDGF-------DQNVNVKVIMATNRADTLDPALLRPGRLDR 325

Query: 375 RIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMR 433
           +I  PLP  + +  +      ++ L  ++ LED   + +  SGADI ++C+++ ++A+R
Sbjct: 326 KIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVR 384


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  143 bits (360), Expect = 4e-34
 Identities = 91/239 (38%), Positives = 136/239 (56%), Gaps = 14/239 (5%)

Query: 201 RNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTMLAK 259
           + P + + DI  ++  K+ +REAV LP+   + +K I   P +GVLM GPPG GKTMLAK
Sbjct: 127 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 186

Query: 260 AVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR--- 316
           AVA      F  V  S    KY GE  ++VR +F +A+  AP  IFIDEID+I ++R   
Sbjct: 187 AVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDA 246

Query: 317 GTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEK 374
            T  + E  +R+  ELL QMDG        D +  V V+ ATN    +D AL R  RL++
Sbjct: 247 QTGADREV-QRILLELLNQMDGF-------DQNVNVKVIMATNRADTLDPALLRPGRLDR 298

Query: 375 RIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMR 433
           +I  PLP  + +  +      ++ L  ++ LED   + +  SGADI ++C+++ ++A+R
Sbjct: 299 KIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVR 357


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  143 bits (360), Expect = 4e-34
 Identities = 91/239 (38%), Positives = 136/239 (56%), Gaps = 14/239 (5%)

Query: 201 RNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTMLAK 259
           + P + + DI  ++  K+ +REAV LP+   + +K I   P +GVLM GPPG GKTMLAK
Sbjct: 158 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 217

Query: 260 AVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR--- 316
           AVA      F  V  S    KY GE  ++VR +F +A+  AP  IFIDEID+I ++R   
Sbjct: 218 AVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDA 277

Query: 317 GTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEK 374
            T  + E  +R+  ELL QMDG        D +  V V+ ATN    +D AL R  RL++
Sbjct: 278 QTGADREV-QRILLELLNQMDGF-------DQNVNVKVIMATNRADTLDPALLRPGRLDR 329

Query: 375 RIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMR 433
           +I  PLP  + +  +      ++ L  ++ LED   + +  SGADI ++C+++ ++A+R
Sbjct: 330 KIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVR 388


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  141 bits (356), Expect = 1e-33
 Identities = 93/248 (37%), Positives = 137/248 (55%), Gaps = 17/248 (6%)

Query: 197 DIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKT 255
           D ++ + S+ +D I  L      L+E VV P+  P+ F+  + +P +G L  GPPGTGKT
Sbjct: 389 DPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKT 448

Query: 256 MLAKAVATECG-----TTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEID 310
           ++A+A+A EC        FF    +   SK+ GESE+ +RLLF+ A    P+ IF DEID
Sbjct: 449 LVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEID 508

Query: 311 SICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR 370
            +   R +S + +    + S LL  MDG+       D    ++V+ ATN    ID ALRR
Sbjct: 509 GLAPVR-SSRQDQIHSSIVSTLLALMDGL-------DNRGEIVVIGATNRLDSIDPALRR 560

Query: 371 --RLEKRIYIPLPTAKGRAELLKINLREVELD-PDIQLEDIAEKIEGYSGADITNVCRDA 427
             R ++     LP  K R  +L+I+ R+      D  L ++AEK  GY GADI  +C +A
Sbjct: 561 PGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEA 620

Query: 428 SLMAMRRR 435
           +L+A+RRR
Sbjct: 621 ALIALRRR 628


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,287,888
Number of Sequences: 37866
Number of extensions: 925602
Number of successful extensions: 4384
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 68
Number of HSP's that attempted gapping in prelim test: 4132
Number of HSP's gapped (non-prelim): 202
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.