Search of human proteins with 46559761

Search of human proteins with 46559761

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46559761 PDZ domain containing 4 [Homo sapiens]
         (769 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46559761 PDZ domain containing 4 [Homo sapiens]                   1542   0.0  
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]        722   0.0  
gi|142976783 PDZ domain containing RING finger 4 [Homo sapiens]       679   0.0  
gi|148746189 multiple PDZ domain protein [Homo sapiens]                54   5e-07
gi|112382257 InaD-like [Homo sapiens]                                  54   7e-07
gi|119120897 par-3 partitioning defective 3 homolog B isoform b ...    53   1e-06
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ...    52   2e-06
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ...    52   2e-06
gi|24025688 ligand of numb-protein X 2 [Homo sapiens]                  52   2e-06
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    51   4e-06
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]    51   5e-06
gi|32479521 dishevelled 1 [Homo sapiens]                               50   6e-06
gi|157388993 synaptojanin 2 binding protein [Homo sapiens]             50   6e-06
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      50   6e-06
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      50   6e-06
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       50   6e-06
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           49   2e-05
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           49   2e-05
gi|116875765 tight junction protein 1 isoform b [Homo sapiens]         48   3e-05
gi|116875767 tight junction protein 1 isoform a [Homo sapiens]         48   3e-05
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    48   3e-05
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    48   3e-05
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]       47   5e-05
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]       47   5e-05
gi|41406097 dishevelled 3 [Homo sapiens]                               47   9e-05
gi|95089461 discs large homolog 5 [Homo sapiens]                       46   1e-04
gi|87196343 PDZ domain containing 2 [Homo sapiens]                     46   1e-04
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...    46   1e-04
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...    46   1e-04
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...    46   1e-04

>gi|46559761 PDZ domain containing 4 [Homo sapiens]
          Length = 769

 Score = 1542 bits (3993), Expect = 0.0
 Identities = 769/769 (100%), Positives = 769/769 (100%)

Query: 1   MGCNMCVVQKPEEQYKVMLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDS 60
           MGCNMCVVQKPEEQYKVMLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDS
Sbjct: 1   MGCNMCVVQKPEEQYKVMLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDS 60

Query: 61  SCHDLQLVDSGTQTDITFEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEA 120
           SCHDLQLVDSGTQTDITFEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEA
Sbjct: 61  SCHDLQLVDSGTQTDITFEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEA 120

Query: 121 DRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDR 180
           DRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDR
Sbjct: 121 DRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDR 180

Query: 181 IIQINGVDVQNREEAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSENEG 240
           IIQINGVDVQNREEAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSENEG
Sbjct: 181 IIQINGVDVQNREEAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSENEG 240

Query: 241 ELRARKLKSPPAQQPGNEEEKGAPDAGPGLSNSQELDSGVGRTDESTRNEESSEHDLLGD 300
           ELRARKLKSPPAQQPGNEEEKGAPDAGPGLSNSQELDSGVGRTDESTRNEESSEHDLLGD
Sbjct: 241 ELRARKLKSPPAQQPGNEEEKGAPDAGPGLSNSQELDSGVGRTDESTRNEESSEHDLLGD 300

Query: 301 EPPSSTNTPGSLRKFGLQGDALQSRDFHFSMDSLLAEGAGLGGGDVPGLTDEEYERYREL 360
           EPPSSTNTPGSLRKFGLQGDALQSRDFHFSMDSLLAEGAGLGGGDVPGLTDEEYERYREL
Sbjct: 301 EPPSSTNTPGSLRKFGLQGDALQSRDFHFSMDSLLAEGAGLGGGDVPGLTDEEYERYREL 360

Query: 361 LEIKCHLENGNQLGLLFPRASGGNSALDVNRNESLGHEMAMLEEELRHLEFKCRNILRAQ 420
           LEIKCHLENGNQLGLLFPRASGGNSALDVNRNESLGHEMAMLEEELRHLEFKCRNILRAQ
Sbjct: 361 LEIKCHLENGNQLGLLFPRASGGNSALDVNRNESLGHEMAMLEEELRHLEFKCRNILRAQ 420

Query: 421 KMQQLRERCMKAWLLEEESLYDLAASEPKKHELSDISELPEKSDKDSTSAYNTGESCRST 480
           KMQQLRERCMKAWLLEEESLYDLAASEPKKHELSDISELPEKSDKDSTSAYNTGESCRST
Sbjct: 421 KMQQLRERCMKAWLLEEESLYDLAASEPKKHELSDISELPEKSDKDSTSAYNTGESCRST 480

Query: 481 PLLVEPLPESPLRRAMAGNSNLNRTPPGPAVATPAKAAPPPGSPAKFRSLSRDPEAGRRQ 540
           PLLVEPLPESPLRRAMAGNSNLNRTPPGPAVATPAKAAPPPGSPAKFRSLSRDPEAGRRQ
Sbjct: 481 PLLVEPLPESPLRRAMAGNSNLNRTPPGPAVATPAKAAPPPGSPAKFRSLSRDPEAGRRQ 540

Query: 541 HAEERGRRNPKTGLTLERVGPESSPYLSRRHRGQGQEGEHYHSCVQLAPTRGLEELGHGP 600
           HAEERGRRNPKTGLTLERVGPESSPYLSRRHRGQGQEGEHYHSCVQLAPTRGLEELGHGP
Sbjct: 541 HAEERGRRNPKTGLTLERVGPESSPYLSRRHRGQGQEGEHYHSCVQLAPTRGLEELGHGP 600

Query: 601 LSLAGGPRVGGVAAAATEAPRMEWKVKVRSDGTRYVAKRPVRDRLLKARALKIREERSGM 660
           LSLAGGPRVGGVAAAATEAPRMEWKVKVRSDGTRYVAKRPVRDRLLKARALKIREERSGM
Sbjct: 601 LSLAGGPRVGGVAAAATEAPRMEWKVKVRSDGTRYVAKRPVRDRLLKARALKIREERSGM 660

Query: 661 TTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREFMMQSRLECLREQQNGDSKPELNI 720
           TTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREFMMQSRLECLREQQNGDSKPELNI
Sbjct: 661 TTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREFMMQSRLECLREQQNGDSKPELNI 720

Query: 721 IALSHRKTMKKRNKKILDNWITIQEMLAHGARSADGKRVYNPLLSVTTV 769
           IALSHRKTMKKRNKKILDNWITIQEMLAHGARSADGKRVYNPLLSVTTV
Sbjct: 721 IALSHRKTMKKRNKKILDNWITIQEMLAHGARSADGKRVYNPLLSVTTV 769


>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
          Length = 1066

 Score =  722 bits (1863), Expect = 0.0
 Identities = 396/779 (50%), Positives = 521/779 (66%), Gaps = 43/779 (5%)

Query: 18   MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
            +++VNG++LS+ + +Q ++A +++KEP+V+QVLRR+PR +  +   + QLVD+GTQTDIT
Sbjct: 304  IIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDIT 363

Query: 78   FEHIMALGKLRPPTPPMV----ILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVEL 133
            FEHIMAL K+  P+PP++    + E  P +HEYYDP +++    QE DR +ELE EEV+L
Sbjct: 364  FEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDR-EELELEEVDL 422

Query: 134  YKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNRE 193
            Y+ + +DKLGL VCYRTDDE+D+GIY+ E++PNSIAAKDGRIREGDRIIQING++VQNRE
Sbjct: 423  YRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNRE 482

Query: 194  EAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSE--NEGELRARKLKSPP 251
            EAVA+L+ EEN N SLL+ARPE QL + W D DR+DFLDD   +   E   +A +  +  
Sbjct: 483  EAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASV 542

Query: 252  AQQPGNEEEKGAPDAGPGLSNSQELDSGVGRTDESTRNEESSEHDLLGDEPPSSTNTPGS 311
             QQ  ++E+ G  D    LSN  E DSGVGRTDESTRN+ESSE +  GD+  +S+N    
Sbjct: 543  LQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPLAG 602

Query: 312  LRKFGLQGDALQSRDFHFSMDSLLAEGAGLGGGDVPGLTDEEYERYRELLEIKCHLENGN 371
             RK     D L S D  FS +S ++  A     D  G+  +E ER+RELLE+KC +++  
Sbjct: 603  QRKLTCSQDTLGSGDLPFSNESFIS--ADCTDADYLGIPVDECERFRELLELKCQVKSAT 660

Query: 372  QLGLLFPRASGGNSALDVNRN--ESLGHEMAMLEEELRHLEFKCRNILRAQKMQQLRERC 429
              GL +P     +  LD  ++  ES+  E+ +L EELR +E +C +I+RA KMQQL+E+ 
Sbjct: 661  PYGLYYP-----SGPLDAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQY 715

Query: 430  MKAWLLEEESLYDLAAS-EPKKHELSDISELPEKSDKDSTSAYNTGESCRSTPLLVEPLP 488
             ++W+L      +   S + ++HELSDI+ELPEKSDKDS+SAYNTGESCRSTPL +E  P
Sbjct: 716  RESWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISP 775

Query: 489  ESPLRRAMAGNSNLNRTPPGPAVATPAKAAPPPGSPAKFRSLSRDPEAGRRQHA------ 542
            ++ LRRA  G S      P    A     A  P S     S++ DPE G   ++      
Sbjct: 776  DNSLRRAAEGISC-----PSSEGAVGTTEAYGPASK-NLLSITEDPEVGTPTYSPSLKEL 829

Query: 543  --------EER----GRRNPKTGLTLERVGPESSPYLSRRHRGQGQEGEHYHSCVQLAPT 590
                    +ER    G R+P     L      S  +   +H       +HY S +QL   
Sbjct: 830  DPNQPLESKERRASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIPAHAQHYQSYMQLIQQ 889

Query: 591  RGLEELGHGPLSLAGGPRVGGVAAAATEAPRMEWKVKVRSDGTRYVAKRPVRDRLLKARA 650
            +   E     +SL    +   +++     PRMEWKVK+RSDGTRY+ KRPVRDRLL+ RA
Sbjct: 890  KSAVEYAQSQMSLVSMCK--DLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERA 947

Query: 651  LKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREFMMQSRLECLREQQ 710
            LKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHL++A+EQR+RREFMMQSRL+CL+EQQ
Sbjct: 948  LKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQ 1007

Query: 711  NGDSKPELNIIALSHRKTMKKRNKKILDNWITIQEMLAHGARSADGKRVYNPLLSVTTV 769
              D + E+NI+ LSH+K MKKRNKKI DNW+TIQE+L HG +S DG RVYN  LSVTTV
Sbjct: 1008 AADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV 1066



 Score = 38.1 bits (87), Expect = 0.031
 Identities = 71/337 (21%), Positives = 127/337 (37%), Gaps = 27/337 (8%)

Query: 151 DDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ--NREEAV-AILSQEENTNI 207
           D     GI+V ++  +  AAK+G ++  DRII++NG D+     ++AV A  + +E   +
Sbjct: 274 DGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVV 333

Query: 208 SLLVARPESQLAKRWKDSDRDD--FLDDFGSENEGELRARKLKSPPAQQPGNEEEKGAPD 265
            +L   P +++     +S   D     D   E+   L      SPP   P        P+
Sbjct: 334 QVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDP-----YLLPE 388

Query: 266 AGPGLSNSQELDSGVGRTDESTRNEESSEHDLLGDEPPSSTNTPGSLRKFGL-------Q 318
             P      + +  +G   +    EE    ++             S  K GL        
Sbjct: 389 EHPSAHEYYDPNDYIGDIHQEMDREELELEEV-------DLYRMNSQDKLGLTVCYRTDD 441

Query: 319 GDALQSRDFHFSMDSLLAEGAGLGGGD-VPGLTDEEYERYRELLEIKCHLENGN-QLGLL 376
            D +         +S+ A+   +  GD +  +   E +   E + +    EN N  L + 
Sbjct: 442 EDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIA 501

Query: 377 FPRASGGNSALDVNRNESLGH-EMAMLEEELRHLEFKCRNILRAQKMQQLRERCMKAWLL 435
            P        +D +RN+ L    M MLEE+         ++L+ +K  +       A +L
Sbjct: 502 RPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHDEDGGTTDTATIL 561

Query: 436 EEESLYDLAASEPKKHELSDISELPEKSDKDSTSAYN 472
             +   D       +   +D S   E +  D+T++ N
Sbjct: 562 SNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSN 598


>gi|142976783 PDZ domain containing RING finger 4 [Homo sapiens]
          Length = 778

 Score =  679 bits (1753), Expect = 0.0
 Identities = 382/793 (48%), Positives = 510/793 (64%), Gaps = 39/793 (4%)

Query: 1   MGCNMCVVQKPEEQYKVML---QVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLR 57
           MGCN+C  QK EE YK++    QVNGK+LSK + E+ ++A R++KEP+V+QVLRR+P  R
Sbjct: 1   MGCNLCTFQKREEHYKLLYEVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSR 60

Query: 58  -GDSSCHDLQLVDSGTQTDITFEHIMALGKLRPPTPPMVILEP----------PPISHEY 106
                  ++QL+++ TQTDITFEHIMAL KLRPPTPP+  + P           P+ HE+
Sbjct: 61  PAYGMASEVQLMNASTQTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEF 120

Query: 107 YDPAEFMEGGPQEADRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPN 166
           Y+  E++   P +ADR ++ EYEEVEL + S ++KLGL VCYRTDDEED GIYV EV+PN
Sbjct: 121 YEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPN 180

Query: 167 SIAAKDGRIREGDRIIQINGVDVQNREEAVAILSQEENTNISLLVARPESQLAKRWKDSD 226
           SIAAKDGRIREGDRI+QING DVQNREEAVA+LS +E   I LLVARPE QL + W + +
Sbjct: 181 SIAAKDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDE 240

Query: 227 RDDFLDDFGSE--NEGELRARKLKSPPAQQP-GNEEEKGAPDAGPGLSNSQELDSGVGRT 283
           R++FL++   E   E    A +  +   +QP   EEE+G  D     SN+ E DSGVGRT
Sbjct: 241 RNEFLEELNLEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRT 300

Query: 284 DESTRNEESSEHDLLGDEPPSSTNTPGSLRKFGLQGDALQSRDFHFSMDSLLAEGAGLGG 343
           DES RN+ESSE +   ++P S++    S R  G   D L S +  ++   +  E      
Sbjct: 301 DESLRNDESSEQENAAEDPNSTSLK--SKRDLGQSQDTLGSVELQYNESLVSGEYI---D 355

Query: 344 GDVPGLTDEEYERYRELLEIKCHLENGNQLGLLFPRASGGNSALDVNRNESLG--HEMAM 401
            D  G  DE+ ER+R+LLE+KC + N  +  L +      +S ++ N+ E  G  HE+ +
Sbjct: 356 SDCIGNPDEDCERFRQLLELKCKIRNHGEYDLYY-----SSSTIECNQGEQEGVEHELQL 410

Query: 402 LEEELRHLEFKCRNILRAQKMQQLRERCMKAWLLEEESLYDLAAS-EPKKHELSDISELP 460
           L EELR++E +C+NI++A ++Q++ ++    W L +    +   S + ++ +L DI E P
Sbjct: 411 LNEELRNIELECQNIMQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHP 470

Query: 461 EKSDKDSTSAYNTGESCRSTPLLVEPLPESPLRRAMAGNSNLNRTPPGPAVATPAKAAPP 520
           EKSDKDS+SAYNT ESCRSTPL V+  P+S L R +   +  N      A  + +  +  
Sbjct: 471 EKSDKDSSSAYNTAESCRSTPLTVDRSPDSSLPRVINLTNKKNLRSTMAATQSSSGQSSK 530

Query: 521 PGSPAKFRSLSRDPEAGRRQHAEERGRRNPKTGLTLERVGPESSPYLSRRHRGQG--QEG 578
             +  K ++  +   A  ++   E G + P     +    P  SPY S  +R        
Sbjct: 531 ESTSTKAKTTEQGCSAESKEKVLE-GSKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHA 589

Query: 579 EHYHSCVQLAPTRGLEELGHGPLSLAGGPRVGGVAAAATEAPRMEWKVKVRSDGTRYVAK 638
            HY S +QL   +   E     LSL    +     +     P+MEWKVK+RSDGTRY+ K
Sbjct: 590 RHYQSYMQLIQQKSAVEYAQSQLSLVSMCK----ESQKCSEPKMEWKVKIRSDGTRYITK 645

Query: 639 RPVRDRLLKARALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREFM 698
           RPVRDR+LK RALKI+EERSGMTTDDD +SEMKMGRYWSKEERKQHL+RA+EQR+RREFM
Sbjct: 646 RPVRDRILKERALKIKEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREFM 705

Query: 699 MQSRLECLRE--QQNGDSKPELNIIALSHRKTMKKRNKKILDNWITIQEMLAHGARSADG 756
           M+SRLECL+E  Q   + K E+NII LSH+K MKKRNKKILDNW+TIQE++ HGA+S DG
Sbjct: 706 MRSRLECLKESPQSGSEGKKEINIIELSHKKMMKKRNKKILDNWMTIQELMTHGAKSPDG 765

Query: 757 KRVYNPLLSVTTV 769
            RV+N  LSVTTV
Sbjct: 766 TRVHNAFLSVTTV 778


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 55/219 (25%), Positives = 99/219 (45%), Gaps = 37/219 (16%)

Query: 19  LQVNGKELSKLSQEQTLQALRSS-KEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
           LQ   +E   ++ E  L  L+S  + PL  Q+L     ++      D   + +   ++I 
Sbjct: 17  LQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQ---QLKDQVNIATSATSNIE 73

Query: 78  FEHIMALGK------------LRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDE 125
           + H+  L              L P    +  L  P I H    PA          D  D+
Sbjct: 74  YAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPA---------CDEFDQ 124

Query: 126 L-----EYEEVELYKSSHRDKLGL---MVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIRE 177
           L     +   VE+++       GL   +V  R+++  +LGI+V E+   S+A +DGR++E
Sbjct: 125 LIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKE 184

Query: 178 GDRIIQINGVDVQ---NREEAVAILSQEENTNISLLVAR 213
            D+I+ ING  +      ++A++IL + ++T + L++AR
Sbjct: 185 TDQILAINGQALDQTITHQQAISILQKAKDT-VQLVIAR 222



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 49/206 (23%), Positives = 86/206 (41%), Gaps = 47/206 (22%)

Query: 18   MLQVNGKELSKLSQEQTLQALRSSKEPLVIQV---LRRSPRLRGDSSCHDLQLVDSGTQT 74
            +++V+G +L   S EQ ++A+R +  P+V  V   + R  +    S  H+L    + + T
Sbjct: 1208 IVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSST 1267

Query: 75   D-------ITFEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGP---------- 117
            +       I  +   +  +  P   P+  + PPP       P+ F E G           
Sbjct: 1268 NPFADSLQINADKAPSQSESEPEKAPLCSVPPPP-------PSAFAEMGSDHTQSSASKI 1320

Query: 118  -QEADRLDELEYE----------------EVELYKSSHRDKLGLMVCYRTDDEEDLGIYV 160
             Q+ D+ DE  Y                  +EL K      LGL +     D   + +++
Sbjct: 1321 SQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKG--HSGLGLSLA-GNKDRSRMSVFI 1377

Query: 161  GEVNPNSIAAKDGRIREGDRIIQING 186
              ++PN  A KDGR++  D +++ING
Sbjct: 1378 VGIDPNGAAGKDGRLQIADELLEING 1403



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 42/143 (29%), Positives = 69/143 (48%), Gaps = 18/143 (12%)

Query: 124  DELEYEE--------VELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRI 175
            DE  Y+E        +EL K   +  LGL +  + +D    G++V ++    IA  DGR+
Sbjct: 1711 DEAPYKEEEVCDTLTIELQKKPGKG-LGLSIVGKRNDT---GVFVSDIVKGGIADADGRL 1766

Query: 176  REGDRIIQINGVDVQN--REEAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDD 233
             +GD+I+ +NG DV+N  +E   A+L   E +  S       S  ++  + S + + L  
Sbjct: 1767 MQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNAL-- 1824

Query: 234  FGSENEGELRARKLKSPPAQQPG 256
              SE +G LR  ++K  P    G
Sbjct: 1825 -ASEIQG-LRTVEMKKGPTDSLG 1845



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 46/199 (23%), Positives = 77/199 (38%), Gaps = 13/199 (6%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
           +L+VNG  L   + +  +  L+     + +   RR+      S    L L D        
Sbjct: 599 LLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPH 658

Query: 78  FEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELYKSS 137
            +    +G      P + + +    + E   P    E G Q            +EL K S
Sbjct: 659 VDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQH-----------IELEKGS 707

Query: 138 HRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNR--EEA 195
                 ++      D     I +  + P  IA KDGR+  GDR++ +N V+++N   EEA
Sbjct: 708 KGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEA 767

Query: 196 VAILSQEENTNISLLVARP 214
           V  L    +  + + VA+P
Sbjct: 768 VEALKGAPSGTVRIGVAKP 786



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 26/59 (44%), Positives = 39/59 (66%), Gaps = 3/59 (5%)

Query: 155  DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ--NREEAVAILSQEENTNISLLV 211
            DL IYV  V     A++DGR++ GD+II +NG  ++    EEAVAIL + + T ++L+V
Sbjct: 1982 DLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGT-VTLMV 2039



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 6/107 (5%)

Query: 124 DELEYEEVELYKSSHRDKLGLMVCYRTDDE--EDLGIYVGEVNPNSIAAKDGRIREGDRI 181
           +E E  +VEL K+     LG+ +     D+  E  GI+V  +  +S    DGRI+ GD+I
Sbjct: 371 EESETFDVELTKNVQG--LGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQI 428

Query: 182 IQINGVDVQ--NREEAVAILSQEENTNISLLVARPESQLAKRWKDSD 226
           I ++G ++Q    ++AV +L     T +  L+ R   Q A+     D
Sbjct: 429 IAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSRED 475



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 36/149 (24%), Positives = 68/149 (45%), Gaps = 23/149 (15%)

Query: 157  GIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ--NREEAVAILSQEENTNISL---LV 211
            GI++  V  +S A K+G ++ GDRI++++G+D++  + E+AV  + +  N  + +   ++
Sbjct: 1184 GIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSII 1243

Query: 212  ARPES--------QLAKRWKDSDRDDFLDDF-------GSENEGELRARKLKSPPAQQPG 256
             RP           L  ++  S  + F D          S++E E     L S P   P 
Sbjct: 1244 NRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPS 1303

Query: 257  NEEEKGAPDAGPGLSNSQELDSGVGRTDE 285
               E G+       S++ ++   V + DE
Sbjct: 1304 AFAEMGSDHT---QSSASKISQDVDKEDE 1329



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 27/75 (36%), Positives = 42/75 (56%), Gaps = 5/75 (6%)

Query: 130  EVELYKSSHRDKLGLMVCYRTDDEEDLG-IYVGEVNPNSIAAKDGRIREGDRIIQINGVD 188
            E  +  S  R  LGL +   +D    LG I + EV     A KDGR+  GD+I+++NG+D
Sbjct: 1627 ETTIEISKGRTGLGLSIVGGSDTL--LGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684

Query: 189  VQ--NREEAVAILSQ 201
            ++    +EA+ +L Q
Sbjct: 1685 LRKATHDEAINVLRQ 1699



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 42/201 (20%), Positives = 82/201 (40%), Gaps = 24/201 (11%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVD---SGTQT 74
           ++ V+G  L   + +Q ++ LR + + +++ ++RR  +   +    +    D   S    
Sbjct: 428 IIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNA 487

Query: 75  DITFEHIMALGKLRPPTPPMVILEPPPISHEYY-----DPAEFMEGGPQEA------DRL 123
            I  E+          T    IL   P   E Y     +  E  +   QEA       R+
Sbjct: 488 SIIKENYEKDEDFLSSTRNTNIL---PTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRI 544

Query: 124 DELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGI-YVGEVNPNSIAAKDGRIREGDRII 182
             + YE V  + S   +  GL +      E  +G  ++  V P       G++  GD ++
Sbjct: 545 MGINYEIVVAHVSKFSENSGLGISL----EATVGHHFIRSVLPEGPVGHSGKLFSGDELL 600

Query: 183 QINGVDV--QNREEAVAILSQ 201
           ++NG+ +  +N ++ V IL +
Sbjct: 601 EVNGITLLGENHQDVVNILKE 621



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 20/90 (22%), Positives = 40/90 (44%), Gaps = 1/90 (1%)

Query: 110  AEFMEGGPQEADRLDELEYEEVELYKSSHRDKLGLMVCYRTDDE-EDLGIYVGEVNPNSI 168
            +E +E   ++     E++       K    D LG+ +         D+ I++  ++P  +
Sbjct: 1812 SESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGV 1871

Query: 169  AAKDGRIREGDRIIQINGVDVQNREEAVAI 198
            AA+  ++R GDRI+ I G   +      A+
Sbjct: 1872 AAQTQKLRVGDRIVTICGTSTEGMTHTQAV 1901



 Score = 33.1 bits (74), Expect = 1.00
 Identities = 17/58 (29%), Positives = 31/58 (53%), Gaps = 1/58 (1%)

Query: 157 GIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN-REEAVAILSQEENTNISLLVAR 213
           G+ V  + P  +A + GR+  GD I++I   D+     E VA + ++    + L++AR
Sbjct: 278 GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR 335



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 28/125 (22%), Positives = 57/125 (45%), Gaps = 12/125 (9%)

Query: 139  RDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNR--EEAV 196
            +D+ GL +    +D    G+ +  +  + +AA DGR++ GD+I+ ++   V     E+ +
Sbjct: 1488 KDQGGLGIAISEEDTLS-GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFI 1546

Query: 197  AILSQEENT-NISLLVARPESQ--------LAKRWKDSDRDDFLDDFGSENEGELRARKL 247
            ++L   + T  +++    P+SQ         +   K+S +   +   GS     +R    
Sbjct: 1547 SLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSR 1606

Query: 248  KSPPA 252
             S PA
Sbjct: 1607 SSTPA 1611


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 52/188 (27%), Positives = 83/188 (44%), Gaps = 11/188 (5%)

Query: 18   MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
            +L+V+G +L   S  + ++A++++  P+V  V   S   R   + H+     +G Q   T
Sbjct: 1125 ILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDT 1184

Query: 78   FEHIMALGKLRPPT----PPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVEL 133
             E         PP     PP   L      +E  D     +   + AD   EL   E+E 
Sbjct: 1185 QEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEK 1244

Query: 134  YKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNR- 192
             K+     LGL +     D   + I+V  +NP   AA DGR+R GD +++IN   +  R 
Sbjct: 1245 DKNG----LGLSLA-GNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRS 1299

Query: 193  -EEAVAIL 199
             + A AI+
Sbjct: 1300 HQNASAII 1307



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 32/90 (35%), Positives = 50/90 (55%), Gaps = 4/90 (4%)

Query: 129  EEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVD 188
            +E+ +  S  R  LGL +    D   +  I + EV     AA+DGR+  GD+I+++NGVD
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLN-AIVIHEVYEEGAAARDGRLWAGDQILEVNGVD 1492

Query: 189  VQN--REEAVAILSQEENTNISLLVARPES 216
            ++N   EEA+  L Q     + L+V R E+
Sbjct: 1493 LRNSSHEEAITALRQTPQ-KVRLVVYRDEA 1521



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 28/93 (30%), Positives = 55/93 (59%), Gaps = 8/93 (8%)

Query: 125 ELEYEEVELYKSSHRDKLGL-MVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQ 183
           ++EY ++E   +     LG  +V  R+ +   + I+V +V P S+A +D R++E D+I+ 
Sbjct: 131 QIEYIDIERPSTGG---LGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILA 187

Query: 184 INGVDVQ---NREEAVAILSQEENTNISLLVAR 213
           IN   +    + ++A+A+L Q+   ++ L+VAR
Sbjct: 188 INHTPLDQNISHQQAIALL-QQTTGSLRLIVAR 219



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 21/58 (36%), Positives = 35/58 (60%), Gaps = 1/58 (1%)

Query: 157 GIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN-REEAVAILSQEENTNISLLVAR 213
           G+ V  + P  +A +DGR++ GD I++I G +VQ    E VA + +    ++ +LVAR
Sbjct: 269 GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 26/91 (28%), Positives = 49/91 (53%), Gaps = 5/91 (5%)

Query: 124  DELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQ 183
            + LE   V+L K + R  LGL +  + +     G+++ ++     A  DGR+ +GD+I+ 
Sbjct: 1527 ENLEIFPVDLQKKAGRG-LGLSIVGKRNGS---GVFISDIVKGGAADLDGRLIQGDQILS 1582

Query: 184  INGVDVQN-REEAVAILSQEENTNISLLVAR 213
            +NG D++N  +E VA + +     + L + R
Sbjct: 1583 VNGEDMRNASQETVATILKCAQGLVQLEIGR 1613



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 20/57 (35%), Positives = 36/57 (63%), Gaps = 1/57 (1%)

Query: 143  GLMVCYRTDDEEDL-GIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVAI 198
            G  V  R  + E+L GI++ +V  +S A K   ++ GD+I++++GVD+QN   + A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAV 1142



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 48/214 (22%), Positives = 90/214 (42%), Gaps = 35/214 (16%)

Query: 18   MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDS--SCHDLQLVDSGTQTD 75
            +L VNG+++   SQE     L+ ++  + +++     RLR  S  S         G+Q  
Sbjct: 1580 ILSVNGEDMRNASQETVATILKCAQGLVQLEI----GRLRAGSWTSARTTSQNSQGSQQS 1635

Query: 76   ITFEHIMALGKLRPPTPPMVI-LEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELY 134
                   A     P   P++  L+    +    DP++   G         ++E   VE+ 
Sbjct: 1636 -------AHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSG--------TDMEPRTVEIN 1680

Query: 135  KSSHRDKLGLMVCY-RTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQING------- 186
            +    D LG+ +   R     D+ +++  +  + +AA+  +++ GDRI+ ING       
Sbjct: 1681 RELS-DALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLS 1739

Query: 187  ----VDVQNREEAVAILSQEENTNISLLVARPES 216
                V++        IL    +TNIS + A+ E+
Sbjct: 1740 HADVVNLLKNAYGRIILQVVADTNISAIAAQLEN 1773



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 21/77 (27%), Positives = 40/77 (51%), Gaps = 3/77 (3%)

Query: 154 EDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ---NREEAVAILSQEENTNISLL 210
           E  GIYV  + P S A  +G I+  D+I+ ++GV++Q   N +    + +  +  +++L+
Sbjct: 391 EASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV 450

Query: 211 VARPESQLAKRWKDSDR 227
             +  S  +     SDR
Sbjct: 451 RRKTSSSTSPLEPPSDR 467


>gi|119120897 par-3 partitioning defective 3 homolog B isoform b
           [Homo sapiens]
          Length = 1143

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 35/87 (40%), Positives = 47/87 (54%), Gaps = 4/87 (4%)

Query: 142 LGLMVCYRTDDEEDLG-IYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNR--EEAVAI 198
           LG  V  R       G I+V  + P   A KDGR++ GDRI+++NG DV  R  EE VA+
Sbjct: 393 LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAM 452

Query: 199 L-SQEENTNISLLVARPESQLAKRWKD 224
           L S ++    SL++AR E     R  D
Sbjct: 453 LRSTKQGETASLVIARQEGHFLPRELD 479



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 42/169 (24%), Positives = 76/169 (44%), Gaps = 21/169 (12%)

Query: 156 LGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVA---ILSQEENTNISLLVA 212
           LG+++  +  NS + ++G   E + I++IN VD+ ++  A A        ++ ++ L V 
Sbjct: 229 LGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVL 288

Query: 213 RPESQLAKRWKDSDRDDFLDDFGSENEGELRARKLKSPPAQQPGNEEEKGAPDAGPGLSN 272
            P++   +   +      L+ FG+ N+G L   K K PP        + G   A    ++
Sbjct: 289 PPQN---REQYEKSVIGSLNIFGN-NDGVL---KTKVPPPV----HGKSGLKTANLTGTD 337

Query: 273 SQELDSGVGRTDESTRNEESSEHDLLGDEPPSSTNTPGSLRKFGLQGDA 321
           S E D+       S +  +S     LG +P S + +P  L  FG   +A
Sbjct: 338 SPETDASA-----SLQQNKSPRVPRLGGKPSSPSLSP--LMGFGSNKNA 379


>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
           [Homo sapiens]
          Length = 1104

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 34/84 (40%), Positives = 46/84 (54%), Gaps = 4/84 (4%)

Query: 142 LGLMVCYRTDDEEDLG-IYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNR--EEAVAI 198
           LG  V  R       G I+V  + P   A KDGR++ GDRI+++NG DV  R  EE VA+
Sbjct: 393 LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAM 452

Query: 199 L-SQEENTNISLLVARPESQLAKR 221
           L S ++    SL++AR E     R
Sbjct: 453 LRSTKQGETASLVIARQEGHFLPR 476



 Score = 34.3 bits (77), Expect = 0.45
 Identities = 14/32 (43%), Positives = 21/32 (65%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQING 186
           DLGI++  +     A KDGR+R  D++I +NG
Sbjct: 524 DLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNG 555



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 42/169 (24%), Positives = 76/169 (44%), Gaps = 21/169 (12%)

Query: 156 LGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVA---ILSQEENTNISLLVA 212
           LG+++  +  NS + ++G   E + I++IN VD+ ++  A A        ++ ++ L V 
Sbjct: 229 LGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVL 288

Query: 213 RPESQLAKRWKDSDRDDFLDDFGSENEGELRARKLKSPPAQQPGNEEEKGAPDAGPGLSN 272
            P++   +   +      L+ FG+ N+G L   K K PP        + G   A    ++
Sbjct: 289 PPQN---REQYEKSVIGSLNIFGN-NDGVL---KTKVPPPV----HGKSGLKTANLTGTD 337

Query: 273 SQELDSGVGRTDESTRNEESSEHDLLGDEPPSSTNTPGSLRKFGLQGDA 321
           S E D+       S +  +S     LG +P S + +P  L  FG   +A
Sbjct: 338 SPETDASA-----SLQQNKSPRVPRLGGKPSSPSLSP--LMGFGSNKNA 379



 Score = 30.4 bits (67), Expect = 6.5
 Identities = 23/69 (33%), Positives = 39/69 (56%), Gaps = 10/69 (14%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSK--EPLVIQVLRRS----PR-LRGDSSCHDLQLVDS 70
           +L+VNG++++  +QE+ +  LRS+K  E   + + R+     PR L+G+  C  L L   
Sbjct: 433 ILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSL--- 489

Query: 71  GTQTDITFE 79
            T   +TFE
Sbjct: 490 ETSEQLTFE 498


>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
           [Homo sapiens]
          Length = 1136

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 34/84 (40%), Positives = 46/84 (54%), Gaps = 4/84 (4%)

Query: 142 LGLMVCYRTDDEEDLG-IYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNR--EEAVAI 198
           LG  V  R       G I+V  + P   A KDGR++ GDRI+++NG DV  R  EE VA+
Sbjct: 393 LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAM 452

Query: 199 L-SQEENTNISLLVARPESQLAKR 221
           L S ++    SL++AR E     R
Sbjct: 453 LRSTKQGETASLVIARQEGHFLPR 476



 Score = 34.3 bits (77), Expect = 0.45
 Identities = 14/32 (43%), Positives = 21/32 (65%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQING 186
           DLGI++  +     A KDGR+R  D++I +NG
Sbjct: 524 DLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNG 555



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 42/169 (24%), Positives = 76/169 (44%), Gaps = 21/169 (12%)

Query: 156 LGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVA---ILSQEENTNISLLVA 212
           LG+++  +  NS + ++G   E + I++IN VD+ ++  A A        ++ ++ L V 
Sbjct: 229 LGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVL 288

Query: 213 RPESQLAKRWKDSDRDDFLDDFGSENEGELRARKLKSPPAQQPGNEEEKGAPDAGPGLSN 272
            P++   +   +      L+ FG+ N+G L   K K PP        + G   A    ++
Sbjct: 289 PPQN---REQYEKSVIGSLNIFGN-NDGVL---KTKVPPPV----HGKSGLKTANLTGTD 337

Query: 273 SQELDSGVGRTDESTRNEESSEHDLLGDEPPSSTNTPGSLRKFGLQGDA 321
           S E D+       S +  +S     LG +P S + +P  L  FG   +A
Sbjct: 338 SPETDASA-----SLQQNKSPRVPRLGGKPSSPSLSP--LMGFGSNKNA 379



 Score = 30.4 bits (67), Expect = 6.5
 Identities = 23/69 (33%), Positives = 39/69 (56%), Gaps = 10/69 (14%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSK--EPLVIQVLRRS----PR-LRGDSSCHDLQLVDS 70
           +L+VNG++++  +QE+ +  LRS+K  E   + + R+     PR L+G+  C  L L   
Sbjct: 433 ILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSL--- 489

Query: 71  GTQTDITFE 79
            T   +TFE
Sbjct: 490 ETSEQLTFE 498


>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
          Length = 690

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 28/89 (31%), Positives = 51/89 (57%), Gaps = 4/89 (4%)

Query: 127 EYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQING 186
           E  +V L+K    ++LG+ +  RTD+    G+++ ++    +AA+DGR+   DR++ ING
Sbjct: 336 EIFQVALHKRDSGEQLGIKLVRRTDEP---GVFILDLLEGGLAAQDGRLSSNDRVLAING 392

Query: 187 VDVQ-NREEAVAILSQEENTNISLLVARP 214
            D++    E  A + Q     ++L +ARP
Sbjct: 393 HDLKYGTPELAAQIIQASGERVNLTIARP 421



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 46/185 (24%), Positives = 82/185 (44%), Gaps = 35/185 (18%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
           +L +NG +L   + E   Q +++S E + + + R      G++      + ++G  +  +
Sbjct: 387 VLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNT------IREAGNHSSSS 440

Query: 78  FEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELYKSS 137
             H          TPP     P   SH+             +  +    + + + + K  
Sbjct: 441 QHH----------TPPPYYSRPS--SHK-------------DLTQCVTCQEKHITVKKEP 475

Query: 138 HRDKLGLMVCY-RTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REE 194
           H + LG+ V   R     +L I+V  V P+   A+DGRI+ GD ++ ING+D+ N    E
Sbjct: 476 H-ESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSE 534

Query: 195 AVAIL 199
           AVA+L
Sbjct: 535 AVAML 539



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 33/112 (29%), Positives = 61/112 (54%), Gaps = 4/112 (3%)

Query: 118 QEADRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIRE 177
           Q+   L E E   +E+++S+   +LG+ +    ++   + I + EV  + + A+DGR+  
Sbjct: 221 QQPLSLPEGEITTIEIHRSNPYIQLGISIV-GGNETPLINIVIQEVYRDGVIARDGRLLA 279

Query: 178 GDRIIQINGVDVQN--REEAVAILSQEENT-NISLLVARPESQLAKRWKDSD 226
           GD+I+Q+N  ++ N     A A+LSQ  NT ++++L  R     A    DS+
Sbjct: 280 GDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSN 331


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 55/235 (23%), Positives = 94/235 (40%), Gaps = 12/235 (5%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
           +L VN   L  +  E+ + +L+++ + + ++V +       D               D  
Sbjct: 278 LLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNH 337

Query: 78  FEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELYKSS 137
             H  +LG L      +    PP +    Y P        ++  R    E  ++ L+K S
Sbjct: 338 ISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTR----EPRKIILHKGS 393

Query: 138 HRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REEA 195
               LG  +    D E   GI+V  +     A   G +R GDRI+ +NGV+++N   E+A
Sbjct: 394 --TGLGFNIVGGEDGE---GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 448

Query: 196 VAILSQEENTNISLLVARPESQLAKRWKDSD-RDDFLDDFGSENEGELRARKLKS 249
            A L +   +   +   RPE       K  D R+  ++   S   G LR  + +S
Sbjct: 449 AAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRS 503



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 24/64 (37%), Positives = 38/64 (59%), Gaps = 3/64 (4%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REEAVAILSQEENTNISLLVA 212
           D  IY+ ++     A KDGR++ GDR++ +N  ++Q+   EEAVA L    +  + L VA
Sbjct: 252 DNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDM-VYLKVA 310

Query: 213 RPES 216
           +P S
Sbjct: 311 KPGS 314



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 26/90 (28%), Positives = 47/90 (52%), Gaps = 5/90 (5%)

Query: 127 EYEEVELYKSSHRDKLGLMVCYRTDDE---EDLGIYVGEVNPNSIAAKDGRIREGDRIIQ 183
           +YEE+ L + +    LG  +    D+    +D GI++ ++ P   AA DGR+   D +++
Sbjct: 128 KYEEIVLERGN--SGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLR 185

Query: 184 INGVDVQNREEAVAILSQEENTNISLLVAR 213
           +N VDV     + A+ + +E   +  LV R
Sbjct: 186 VNEVDVSEVVHSRAVEALKEAGPVVRLVVR 215


>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
          Length = 1356

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 28/67 (41%), Positives = 43/67 (64%), Gaps = 3/67 (4%)

Query: 158 IYVGEVNPNSIAAKDGRIREGDRIIQINGVDV--QNREEAVAIL-SQEENTNISLLVARP 214
           IYV  + P   A +DGR++ GDR+I++NGVD+  +++EE V++L S +    +SLLV R 
Sbjct: 488 IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ 547

Query: 215 ESQLAKR 221
           E     R
Sbjct: 548 EDAFHPR 554



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 53/206 (25%), Positives = 85/206 (41%), Gaps = 44/206 (21%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
           +++VNG +L   SQE+ +  LRS+K    + +L      R + + H  +L    +Q    
Sbjct: 511 LIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLV----FRQEDAFHPRELNAEPSQ---- 562

Query: 78  FEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELYKSS 137
               M + K        ++L P                     D   E    EV L  S 
Sbjct: 563 ----MQIPKETKAEDEDIVLTP---------------------DGTREFLTFEVPLNDSG 597

Query: 138 HRDKLGLMVCYRTDDEE--DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDV--QNRE 193
               LG+ V      E   DLGI+V  +     A+KDGR+R  D++I +NG  +  +  +
Sbjct: 598 SAG-LGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656

Query: 194 EAVAILSQEENTN------ISLLVAR 213
           +A+  L +  +T       I L+VAR
Sbjct: 657 DAMETLRRSMSTEGNKRGMIQLIVAR 682



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 35/137 (25%), Positives = 55/137 (40%), Gaps = 24/137 (17%)

Query: 156 LGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNR--EEAVAILSQEENTNISLLVAR 213
           LG+ V  +     A  +   RE D I++IN  D++NR  E+A  +  Q   T I      
Sbjct: 299 LGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVV 358

Query: 214 PES------QLAKRWKD-------SDRDDFLDDFGSENEG---ELRARKLKSPPAQ---- 253
           P +      QL++  K+       S    ++D+    + G     RA +L  PP Q    
Sbjct: 359 PAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSH 418

Query: 254 --QPGNEEEKGAPDAGP 268
              P +    G P + P
Sbjct: 419 SRLPHSAHPSGKPPSAP 435


>gi|32479521 dishevelled 1 [Homo sapiens]
          Length = 670

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 27/76 (35%), Positives = 45/76 (59%), Gaps = 4/76 (5%)

Query: 142 LGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REEAVAIL 199
           LG+ +  +++D  D GIY+G +      A DGRI  GD ++Q+N V+ +N   ++AV +L
Sbjct: 262 LGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321

Query: 200 SQ--EENTNISLLVAR 213
            +   +   ISL VA+
Sbjct: 322 REIVSQTGPISLTVAK 337


>gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
          Length = 145

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 29/73 (39%), Positives = 42/73 (57%), Gaps = 4/73 (5%)

Query: 122 RLDELEYEEVELYKSSHRDKLGLMVCYRTDDE---EDLGIYVGEVNPNSIAAKDGRIREG 178
           R+D L  EE E+  +     LG  +   TD +    D GIYV  +  N  AA DGR++EG
Sbjct: 4   RVDYLVTEE-EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEG 62

Query: 179 DRIIQINGVDVQN 191
           D+I+ +NG D++N
Sbjct: 63  DKILSVNGQDLKN 75


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 3/92 (3%)

Query: 125 ELEYEEVELYKSSHRDKLGLMVCYRTDDE---EDLGIYVGEVNPNSIAAKDGRIREGDRI 181
           E+EYE  E+        LG  +   TD+    +D GI++ ++ P   AA+DGR+R  D I
Sbjct: 40  EIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 99

Query: 182 IQINGVDVQNREEAVAILSQEENTNISLLVAR 213
           +++N VDV     + A+ + +E  +I  L  R
Sbjct: 100 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 131



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 57/249 (22%), Positives = 104/249 (41%), Gaps = 24/249 (9%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRS----------PRLRGDSSCHDLQL 67
           +L VN   L +++ E+ +  L+++ E + ++V + +          P +    S      
Sbjct: 194 LLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENH 253

Query: 68  VDSGTQTDITFEHIMALGKLRP----PTPPMVILEPPPISHEYYDPAEFMEGGPQEADRL 123
           + SG     T E+  +L  + P    P P  ++++    SH  +  A        +    
Sbjct: 254 LLSGNNG--TLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVS 311

Query: 124 DELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQ 183
            E E  +V L+K S    LG  +    D E   GI+V  +     A   G ++ GD+I+ 
Sbjct: 312 LEGEPRKVVLHKGS--TGLGFNIVGGEDGE---GIFVSFILAGGPADLSGELQRGDQILS 366

Query: 184 INGVDVQ--NREEAVAILSQEENTNISLLVARPESQLAKRWKDSD-RDDFLDDFGSENEG 240
           +NG+D++  + E+A A L     T   +   +PE       K  D R+  ++   S   G
Sbjct: 367 VNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSG 426

Query: 241 ELRARKLKS 249
            LR  + +S
Sbjct: 427 SLRTNQKRS 435



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 23/62 (37%), Positives = 34/62 (54%), Gaps = 3/62 (4%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ--NREEAVAILSQEENTNISLLVA 212
           D  IYV ++     A KDGR++ GDR++ +N   ++    EEAVAIL       + L V 
Sbjct: 168 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEV-VYLKVG 226

Query: 213 RP 214
           +P
Sbjct: 227 KP 228


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 3/92 (3%)

Query: 125 ELEYEEVELYKSSHRDKLGLMVCYRTDDE---EDLGIYVGEVNPNSIAAKDGRIREGDRI 181
           E+EYE  E+        LG  +   TD+    +D GI++ ++ P   AA+DGR+R  D I
Sbjct: 196 EIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 255

Query: 182 IQINGVDVQNREEAVAILSQEENTNISLLVAR 213
           +++N VDV     + A+ + +E  +I  L  R
Sbjct: 256 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 287



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 23/62 (37%), Positives = 34/62 (54%), Gaps = 3/62 (4%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ--NREEAVAILSQEENTNISLLVA 212
           D  IYV ++     A KDGR++ GDR++ +N   ++    EEAVAIL       + L V 
Sbjct: 324 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEV-VYLKVG 382

Query: 213 RP 214
           +P
Sbjct: 383 KP 384



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 36/128 (28%), Positives = 58/128 (45%), Gaps = 8/128 (6%)

Query: 125 ELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQI 184
           E E  +V L+K S    LG  +    D E   GI+V  +     A   G ++ GD+I+ +
Sbjct: 521 EGEPRKVVLHKGS--TGLGFNIVGGEDGE---GIFVSFILAGGPADLSGELQRGDQILSV 575

Query: 185 NGVDVQ--NREEAVAILSQEENTNISLLVARPESQLAKRWKDSD-RDDFLDDFGSENEGE 241
           NG+D++  + E+A A L     T   +   +PE       K  D R+  ++   S   G 
Sbjct: 576 NGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGS 635

Query: 242 LRARKLKS 249
           LR  + +S
Sbjct: 636 LRTNQKRS 643


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 3/92 (3%)

Query: 125 ELEYEEVELYKSSHRDKLGLMVCYRTDDE---EDLGIYVGEVNPNSIAAKDGRIREGDRI 181
           E+EYE  E+        LG  +   TD+    +D GI++ ++ P   AA+DGR+R  D I
Sbjct: 91  EIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 150

Query: 182 IQINGVDVQNREEAVAILSQEENTNISLLVAR 213
           +++N VDV     + A+ + +E  +I  L  R
Sbjct: 151 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 182



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 23/62 (37%), Positives = 34/62 (54%), Gaps = 3/62 (4%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ--NREEAVAILSQEENTNISLLVA 212
           D  IYV ++     A KDGR++ GDR++ +N   ++    EEAVAIL       + L V 
Sbjct: 219 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEV-VYLKVG 277

Query: 213 RP 214
           +P
Sbjct: 278 KP 279



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 36/128 (28%), Positives = 58/128 (45%), Gaps = 8/128 (6%)

Query: 125 ELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQI 184
           E E  +V L+K S    LG  +    D E   GI+V  +     A   G ++ GD+I+ +
Sbjct: 416 EGEPRKVVLHKGS--TGLGFNIVGGEDGE---GIFVSFILAGGPADLSGELQRGDQILSV 470

Query: 185 NGVDVQ--NREEAVAILSQEENTNISLLVARPESQLAKRWKDSD-RDDFLDDFGSENEGE 241
           NG+D++  + E+A A L     T   +   +PE       K  D R+  ++   S   G 
Sbjct: 471 NGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGS 530

Query: 242 LRARKLKS 249
           LR  + +S
Sbjct: 531 LRTNQKRS 538


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 57/235 (24%), Positives = 95/235 (40%), Gaps = 25/235 (10%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
           +L VN   L +++ E+ + AL+++ + + ++V + +           + + D     DIT
Sbjct: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPT----------SMYMNDGYAPPDIT 420

Query: 78  FEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELYKSS 137
                 +        P   L   P S   Y P      G  E  R    E  +V L++ S
Sbjct: 421 NSSSQPVDN---HVSPSSFLGQTPASPARYSPVSKAVLGDDEITR----EPRKVVLHRGS 473

Query: 138 HRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ--NREEA 195
               LG  +    D E   GI++  +     A   G +R+GDRII +N VD++  + E+A
Sbjct: 474 --TGLGFNIVGGEDGE---GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQA 528

Query: 196 VAILSQEENTNISLLVARPESQLAKRWKDSD-RDDFLDDFGSENEGELRARKLKS 249
            A L         +   RPE       K  D R+  ++   S   G LR  + +S
Sbjct: 529 AAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRS 583



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 37/149 (24%), Positives = 68/149 (45%), Gaps = 18/149 (12%)

Query: 89  PPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELE-------------YEEVELYK 135
           PPT P++ + P P  +    P       P      D LE             YEE+ L +
Sbjct: 170 PPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLER 229

Query: 136 SSHRDKLGLMVCYRTDDE---EDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNR 192
            +    LG  +   TD+    +D  I++ ++     AA+DGR+R  D I+++N VDV++ 
Sbjct: 230 GN--SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDV 287

Query: 193 EEAVAILSQEENTNISLLVARPESQLAKR 221
             + A+ + +E  +I  L  +    ++++
Sbjct: 288 THSKAVEALKEAGSIVRLYVKRRKPVSEK 316



 Score = 36.6 bits (83), Expect = 0.090
 Identities = 22/64 (34%), Positives = 36/64 (56%), Gaps = 3/64 (4%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ--NREEAVAILSQEENTNISLLVA 212
           D  IYV ++     A KDG+++ GD+++ +N V ++    EEAV  L    +  + L VA
Sbjct: 345 DNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDF-VYLKVA 403

Query: 213 RPES 216
           +P S
Sbjct: 404 KPTS 407


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 57/235 (24%), Positives = 95/235 (40%), Gaps = 25/235 (10%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
           +L VN   L +++ E+ + AL+++ + + ++V + +           + + D     DIT
Sbjct: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPT----------SMYMNDGYAPPDIT 420

Query: 78  FEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELYKSS 137
                 +        P   L   P S   Y P      G  E  R    E  +V L++ S
Sbjct: 421 NSSSQPVDN---HVSPSSFLGQTPASPARYSPVSKAVLGDDEITR----EPRKVVLHRGS 473

Query: 138 HRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ--NREEA 195
               LG  +    D E   GI++  +     A   G +R+GDRII +N VD++  + E+A
Sbjct: 474 --TGLGFNIVGGEDGE---GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQA 528

Query: 196 VAILSQEENTNISLLVARPESQLAKRWKDSD-RDDFLDDFGSENEGELRARKLKS 249
            A L         +   RPE       K  D R+  ++   S   G LR  + +S
Sbjct: 529 AAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRS 583



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 37/149 (24%), Positives = 68/149 (45%), Gaps = 18/149 (12%)

Query: 89  PPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELE-------------YEEVELYK 135
           PPT P++ + P P  +    P       P      D LE             YEE+ L +
Sbjct: 170 PPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLER 229

Query: 136 SSHRDKLGLMVCYRTDDE---EDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNR 192
            +    LG  +   TD+    +D  I++ ++     AA+DGR+R  D I+++N VDV++ 
Sbjct: 230 GN--SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDV 287

Query: 193 EEAVAILSQEENTNISLLVARPESQLAKR 221
             + A+ + +E  +I  L  +    ++++
Sbjct: 288 THSKAVEALKEAGSIVRLYVKRRKPVSEK 316



 Score = 36.6 bits (83), Expect = 0.090
 Identities = 22/64 (34%), Positives = 36/64 (56%), Gaps = 3/64 (4%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ--NREEAVAILSQEENTNISLLVA 212
           D  IYV ++     A KDG+++ GD+++ +N V ++    EEAV  L    +  + L VA
Sbjct: 345 DNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDF-VYLKVA 403

Query: 213 RPES 216
           +P S
Sbjct: 404 KPTS 407


>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
          Length = 1668

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 41/139 (29%), Positives = 66/139 (47%), Gaps = 12/139 (8%)

Query: 98  EPPPISHEYYDPAEFMEGGPQE-----ADRLDELEYEEVELYKSSHRDKLGLMVCYRTDD 152
           EP P+  +   P   +   P +     +   D +    ++L K    D +GL    R   
Sbjct: 384 EPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGL----RLAG 439

Query: 153 EEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REEAVAILSQEENTNISLL 210
             D+GI+V  V  +S AAK+G + EGD+I+++N VD  N  REEAV  L          +
Sbjct: 440 GNDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTI 498

Query: 211 VARPESQLAKRWKDSDRDD 229
           +A+ +  + +R  +SD  D
Sbjct: 499 LAQKKKDVYRRIVESDVGD 517



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 37/144 (25%), Positives = 63/144 (43%), Gaps = 21/144 (14%)

Query: 130 EVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDV 189
           +V L KS   ++ GL +           I+V E++ +S+AA+DG I+EGD +++ING   
Sbjct: 186 KVTLVKSRKNEEYGLRLASH--------IFVKEISQDSLAARDGNIQEGDVVLKINGTVT 237

Query: 190 QNREEAVA-ILSQEENTNISLLVARPESQLAKRWKD----------SDRDDF--LDDFGS 236
           +N     A  L +     + ++V R E        D          S+RDD   +    S
Sbjct: 238 ENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLAS 297

Query: 237 ENEGELRARKLKSPPAQQPGNEEE 260
           ++ G    R  +   ++ P    E
Sbjct: 298 DHSGRSHDRPPRRSRSRSPDQRSE 321



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 29/132 (21%), Positives = 58/132 (43%), Gaps = 12/132 (9%)

Query: 172 DGRIREGDRIIQINGVDVQNREEAVAI-----------LSQEENTNISLLVARPESQLAK 220
           +G+++E DR+  +NGV + N E A A+           ++      + + V+RP+ +   
Sbjct: 66  EGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125

Query: 221 RWKDSDRDDFLDDFGSENEGELRARKLKSPPAQQPGNEEEKGAPDAG-PGLSNSQELDSG 279
             ++   D+ + D  S   G +  R  K  P  +  + E   +P +    +++SQ     
Sbjct: 126 DNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPT 185

Query: 280 VGRTDESTRNEE 291
                +S +NEE
Sbjct: 186 KVTLVKSRKNEE 197


>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
          Length = 1748

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 41/139 (29%), Positives = 66/139 (47%), Gaps = 12/139 (8%)

Query: 98  EPPPISHEYYDPAEFMEGGPQE-----ADRLDELEYEEVELYKSSHRDKLGLMVCYRTDD 152
           EP P+  +   P   +   P +     +   D +    ++L K    D +GL    R   
Sbjct: 384 EPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGL----RLAG 439

Query: 153 EEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REEAVAILSQEENTNISLL 210
             D+GI+V  V  +S AAK+G + EGD+I+++N VD  N  REEAV  L          +
Sbjct: 440 GNDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTI 498

Query: 211 VARPESQLAKRWKDSDRDD 229
           +A+ +  + +R  +SD  D
Sbjct: 499 LAQKKKDVYRRIVESDVGD 517



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 37/144 (25%), Positives = 63/144 (43%), Gaps = 21/144 (14%)

Query: 130 EVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDV 189
           +V L KS   ++ GL +           I+V E++ +S+AA+DG I+EGD +++ING   
Sbjct: 186 KVTLVKSRKNEEYGLRLASH--------IFVKEISQDSLAARDGNIQEGDVVLKINGTVT 237

Query: 190 QNREEAVA-ILSQEENTNISLLVARPESQLAKRWKD----------SDRDDF--LDDFGS 236
           +N     A  L +     + ++V R E        D          S+RDD   +    S
Sbjct: 238 ENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLAS 297

Query: 237 ENEGELRARKLKSPPAQQPGNEEE 260
           ++ G    R  +   ++ P    E
Sbjct: 298 DHSGRSHDRPPRRSRSRSPDQRSE 321



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 29/132 (21%), Positives = 58/132 (43%), Gaps = 12/132 (9%)

Query: 172 DGRIREGDRIIQINGVDVQNREEAVAI-----------LSQEENTNISLLVARPESQLAK 220
           +G+++E DR+  +NGV + N E A A+           ++      + + V+RP+ +   
Sbjct: 66  EGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125

Query: 221 RWKDSDRDDFLDDFGSENEGELRARKLKSPPAQQPGNEEEKGAPDAG-PGLSNSQELDSG 279
             ++   D+ + D  S   G +  R  K  P  +  + E   +P +    +++SQ     
Sbjct: 126 DNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPT 185

Query: 280 VGRTDESTRNEE 291
                +S +NEE
Sbjct: 186 KVTLVKSRKNEE 197


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 28/86 (32%), Positives = 49/86 (56%), Gaps = 5/86 (5%)

Query: 125 ELEYEEVELYKSSHRDKLGLMVCYRTDDE---EDLGIYVGEVNPNSIAAKDGRIREGDRI 181
           E+EYEE+ L + +    LG  +   TD+    +D  I++ ++ P   AA+DGR+R  D I
Sbjct: 103 EMEYEEITLERGN--SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 160

Query: 182 IQINGVDVQNREEAVAILSQEENTNI 207
           + +N VDV+    + A+ + +E  +I
Sbjct: 161 LFVNEVDVREVTHSAAVEALKEAGSI 186



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 47/200 (23%), Positives = 78/200 (39%), Gaps = 18/200 (9%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
           +L VN   L  +  E  + AL+++ + + ++V + S     DS              D  
Sbjct: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 314

Query: 78  FEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELYKSS 137
             H   LG   P           P S   Y P      G ++  R    E   + +++ S
Sbjct: 315 ISHSSYLGTDYPTAMT-------PTSPRRYSPVAKDLLGEEDIPR----EPRRIVIHRGS 363

Query: 138 HRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REEA 195
               LG  +    D E   GI++  +     A   G +R+GD+I+ +NGVD++N   E+A
Sbjct: 364 --TGLGFNIVGGEDGE---GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 418

Query: 196 VAILSQEENTNISLLVARPE 215
              L     T   +   +PE
Sbjct: 419 AIALKNAGQTVTIIAQYKPE 438



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 23/64 (35%), Positives = 38/64 (59%), Gaps = 3/64 (4%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REEAVAILSQEENTNISLLVA 212
           D  IYV ++     A KDGR++ GD+I+ +N V +++   E+AVA L    +  + L VA
Sbjct: 229 DNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDV-VYLKVA 287

Query: 213 RPES 216
           +P +
Sbjct: 288 KPSN 291


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 28/86 (32%), Positives = 49/86 (56%), Gaps = 5/86 (5%)

Query: 125 ELEYEEVELYKSSHRDKLGLMVCYRTDDE---EDLGIYVGEVNPNSIAAKDGRIREGDRI 181
           E+EYEE+ L + +    LG  +   TD+    +D  I++ ++ P   AA+DGR+R  D I
Sbjct: 57  EMEYEEITLERGN--SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 114

Query: 182 IQINGVDVQNREEAVAILSQEENTNI 207
           + +N VDV+    + A+ + +E  +I
Sbjct: 115 LFVNEVDVREVTHSAAVEALKEAGSI 140



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 47/200 (23%), Positives = 78/200 (39%), Gaps = 18/200 (9%)

Query: 18  MLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDIT 77
           +L VN   L  +  E  + AL+++ + + ++V + S     DS              D  
Sbjct: 209 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 268

Query: 78  FEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELYKSS 137
             H   LG   P           P S   Y P      G ++  R    E   + +++ S
Sbjct: 269 ISHSSYLGTDYPTAMT-------PTSPRRYSPVAKDLLGEEDIPR----EPRRIVIHRGS 317

Query: 138 HRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REEA 195
               LG  +    D E   GI++  +     A   G +R+GD+I+ +NGVD++N   E+A
Sbjct: 318 --TGLGFNIVGGEDGE---GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 372

Query: 196 VAILSQEENTNISLLVARPE 215
              L     T   +   +PE
Sbjct: 373 AIALKNAGQTVTIIAQYKPE 392



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 23/64 (35%), Positives = 38/64 (59%), Gaps = 3/64 (4%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REEAVAILSQEENTNISLLVA 212
           D  IYV ++     A KDGR++ GD+I+ +N V +++   E+AVA L    +  + L VA
Sbjct: 183 DNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDV-VYLKVA 241

Query: 213 RPES 216
           +P +
Sbjct: 242 KPSN 245


>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
          Length = 728

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 27/81 (33%), Positives = 47/81 (58%), Gaps = 3/81 (3%)

Query: 128 YEEVELYKSSHRDKLGLMVCYRTDDEE-DLGIYVGEVNPNSIAAKDGRIREGDRIIQING 186
           +E+V   +    + LG+ V       E DL IYV  V P  + ++DGRI+ GD ++ ++G
Sbjct: 504 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 563

Query: 187 VDVQ--NREEAVAILSQEENT 205
           V++   +R EAVA+L +  ++
Sbjct: 564 VELTEVSRSEAVALLKRTSSS 584



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 27/88 (30%), Positives = 48/88 (54%), Gaps = 4/88 (4%)

Query: 131 VELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ 190
           V L KSS  ++LG+ +  + D+    G+++  V    +A + G++ E DR++ ING D++
Sbjct: 382 VILNKSSPEEQLGIKLVRKVDEP---GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLR 438

Query: 191 -NREEAVAILSQEENTNISLLVARPESQ 217
               E+ A L Q     + L+V+R   Q
Sbjct: 439 YGSPESAAHLIQASERRVHLVVSRQVRQ 466



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 36/154 (23%), Positives = 64/154 (41%), Gaps = 11/154 (7%)

Query: 158 IYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVAILSQEENTNISLLVARPESQ 217
           I +  +  + + A+DGR+  GD I+++NG+D+ N     A+    +   +  L    E +
Sbjct: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 360

Query: 218 LAKRWKDSDRDDFLDDFGSENEGELRARKLKSPPAQQPGNEEEKGAPDAGPGLSNSQELD 277
              R      D +        +        KS P +Q G +  +   +  PG+     LD
Sbjct: 361 FRSRNNGQAPDAY-----RPRDDSFHVILNKSSPEEQLGIKLVRKVDE--PGVFIFNVLD 413

Query: 278 SGV----GRTDESTRNEESSEHDLLGDEPPSSTN 307
            GV    G+ +E+ R    + HDL    P S+ +
Sbjct: 414 GGVAYRHGQLEENDRVLAINGHDLRYGSPESAAH 447


>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
          Length = 632

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 27/81 (33%), Positives = 47/81 (58%), Gaps = 3/81 (3%)

Query: 128 YEEVELYKSSHRDKLGLMVCYRTDDEE-DLGIYVGEVNPNSIAAKDGRIREGDRIIQING 186
           +E+V   +    + LG+ V       E DL IYV  V P  + ++DGRI+ GD ++ ++G
Sbjct: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467

Query: 187 VDVQ--NREEAVAILSQEENT 205
           V++   +R EAVA+L +  ++
Sbjct: 468 VELTEVSRSEAVALLKRTSSS 488



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 27/88 (30%), Positives = 48/88 (54%), Gaps = 4/88 (4%)

Query: 131 VELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQ 190
           V L KSS  ++LG+ +  + D+    G+++  V    +A + G++ E DR++ ING D++
Sbjct: 286 VILNKSSPEEQLGIKLVRKVDEP---GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLR 342

Query: 191 -NREEAVAILSQEENTNISLLVARPESQ 217
               E+ A L Q     + L+V+R   Q
Sbjct: 343 YGSPESAAHLIQASERRVHLVVSRQVRQ 370



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 36/154 (23%), Positives = 64/154 (41%), Gaps = 11/154 (7%)

Query: 158 IYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVAILSQEENTNISLLVARPESQ 217
           I +  +  + + A+DGR+  GD I+++NG+D+ N     A+    +   +  L    E +
Sbjct: 205 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 264

Query: 218 LAKRWKDSDRDDFLDDFGSENEGELRARKLKSPPAQQPGNEEEKGAPDAGPGLSNSQELD 277
              R      D +        +        KS P +Q G +  +   +  PG+     LD
Sbjct: 265 FRSRNNGQAPDAY-----RPRDDSFHVILNKSSPEEQLGIKLVRKVDE--PGVFIFNVLD 317

Query: 278 SGV----GRTDESTRNEESSEHDLLGDEPPSSTN 307
            GV    G+ +E+ R    + HDL    P S+ +
Sbjct: 318 GGVAYRHGQLEENDRVLAINGHDLRYGSPESAAH 351


>gi|41406097 dishevelled 3 [Homo sapiens]
          Length = 716

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 28/94 (29%), Positives = 49/94 (52%), Gaps = 13/94 (13%)

Query: 142 LGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQN--REEAVAIL 199
           LG+ +  ++++  D GIY+G +      A DGRI  GD ++Q+N ++ +N   ++AV +L
Sbjct: 260 LGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVL 319

Query: 200 SQEENTNISLLVARP---ESQLAKRWKDSDRDDF 230
            +        +V +P      +AK W  S R  F
Sbjct: 320 RE--------IVHKPGPITLTVAKCWDPSPRGCF 345


>gi|95089461 discs large homolog 5 [Homo sapiens]
          Length = 1919

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 29/80 (36%), Positives = 46/80 (57%), Gaps = 9/80 (11%)

Query: 157 GIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNR--EEAVAIL-SQEENTNISLLVAR 213
           G+Y   V P S AAK+G +  GDRI+ ING+ + N+   E  ++L S +++  +SLL   
Sbjct: 737 GVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVF 796

Query: 214 PES------QLAKRWKDSDR 227
           P+S       + +  KDSD+
Sbjct: 797 PQSSSWSGQNIFENIKDSDK 816



 Score = 38.1 bits (87), Expect = 0.031
 Identities = 20/44 (45%), Positives = 31/44 (70%), Gaps = 2/44 (4%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVAI 198
           D GI+V +V+  SIA  DGR+R  D +++IN VD+ N+++  AI
Sbjct: 651 DCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDLINKDKKQAI 692



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 36/161 (22%), Positives = 68/161 (42%), Gaps = 7/161 (4%)

Query: 116  GPQEADRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRI 175
            G +  DR    E   V++ K S  + LG+ +       E  GIYV +V   SIA + G +
Sbjct: 1336 GERRKDRPYVEEPRHVKVQKGS--EPLGISIV----SGEKGGIYVSKVTVGSIAHQAG-L 1388

Query: 176  REGDRIIQINGVDVQNREEAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFG 235
              GD++++ NG+++++  E  A L   +  +   ++A+    + +    S     LD  G
Sbjct: 1389 EYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAG 1448

Query: 236  SENEGELRARKLKSPPAQQPGNEEEKGAPDAGPGLSNSQEL 276
            + +  +         P+      E+   P   P   +S  +
Sbjct: 1449 THSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRI 1489


>gi|87196343 PDZ domain containing 2 [Homo sapiens]
          Length = 2839

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 61/203 (30%), Positives = 85/203 (41%), Gaps = 37/203 (18%)

Query: 108 DPAEFMEGGPQEADRLDELEYEEV------ELYKSSHRDKLGLMVCY-RTDDEEDLGIYV 160
           D   F +GG  +    D L  EEV      EL K S  D LG+ V   R        I V
Sbjct: 306 DKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKES--DGLGIQVSGGRGSKRSPHAIVV 363

Query: 161 GEVNPNSIAAKDGRIREGDRIIQING--VDVQNREEAVAIL-----------SQEENTNI 207
            +V     A +DGR+  GD ++ ING  +   + EEAVAIL           + +EN+  
Sbjct: 364 TQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAE 423

Query: 208 SLLVARPES--------QLAKRWKDSDRDDFLDDFGSENEGELRARKLKSPPAQQP---- 255
            LL    +S        +    W D++ D   D  G E+EG   + +   P   +P    
Sbjct: 424 DLLRLTSKSLPDLTSSVEDVSSWTDNE-DQEAD--GEEDEGTSSSVQRAMPGTDEPQDVC 480

Query: 256 GNEEEKGAPDAGPGLSNSQELDS 278
           G EE KG  ++    SN  +L S
Sbjct: 481 GAEESKGNLESPKQGSNKIKLKS 503



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 19/48 (39%), Positives = 32/48 (66%), Gaps = 2/48 (4%)

Query: 156 LGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNR--EEAVAILSQ 201
           +GI+V  + PN  AA+DGR++EGD I+ +NG+ ++    +EA+    Q
Sbjct: 612 MGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQ 659



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 53/207 (25%), Positives = 89/207 (42%), Gaps = 21/207 (10%)

Query: 130 EVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDV 189
           EV L K   R  LG+  C    +    GIY+  + P S+A  +  +  GD+I+++N V+V
Sbjct: 728 EVTLNKEP-RVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNV 786

Query: 190 QNR--EEAVAILSQEENTNISLLVAR-PESQLAKRWKDS--DRDDFLDDFGSENEGELRA 244
           ++    +  AILS+     + L++ R P  +++++  D    R  + +   + +   L  
Sbjct: 787 RHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGL-G 845

Query: 245 RKLKSPPAQQPG---NEEEKGAPDA----GP-------GLSNSQELDSGVGRTDESTRNE 290
             LKSP   +     +E E     A    GP       G  +     SG   ++E +   
Sbjct: 846 TPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPP 905

Query: 291 ESSEHDLLGDEPPSSTNTPGSLRKFGL 317
            +S H   G    +S  T GS R  GL
Sbjct: 906 STSTHKEPGKPRANSLVTLGSHRASGL 932



 Score = 33.1 bits (74), Expect = 1.00
 Identities = 42/170 (24%), Positives = 68/170 (40%), Gaps = 19/170 (11%)

Query: 155 DLG-IYVGEVNPNSIAAKDGRIREGDRIIQIN-----GVDVQNREEAVAILSQEENTNIS 208
           D+G I+V E+  NS A K G++R  D I+ +N     GVDV     A  +  Q  N    
Sbjct: 115 DVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSG---ASYLAEQCWNGGFI 171

Query: 209 LLVARPESQLAKRWKDSDRDDFLDDFGSENE-GELRARKLKSPPAQQPGNEEEKGAPDAG 267
            L+      + +R+K      +  +  + +E GE    +L    A++     + G     
Sbjct: 172 YLI------MLRRFKHKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRP 225

Query: 268 PGLSNSQELDSGVG---RTDESTRNEESSEHDLLGDEPPSSTNTPGSLRK 314
           P     +E     G    +D ST  E   + +L         N P SL++
Sbjct: 226 PANKAPEESKGSAGCEVSSDPSTELENGPDPELGNGHVFQLENGPDSLKE 275


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 21/67 (31%), Positives = 41/67 (61%), Gaps = 1/67 (1%)

Query: 155  DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVAI-LSQEENTNISLLVAR 213
            DLGI++  V P   A  DG ++ GDR+I +N V ++      AI + Q    +++L++++
Sbjct: 1118 DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1177

Query: 214  PESQLAK 220
            P+ +++K
Sbjct: 1178 PKEKISK 1184



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 37/125 (29%), Positives = 59/125 (47%), Gaps = 11/125 (8%)

Query: 130  EVELYKSSHRDKLGLMVCYRTD------DEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQ 183
            EVEL K+ +   LG+ V    D           GIYV  V P   A  DGRI +GDR++ 
Sbjct: 1368 EVELAKNDN--SLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLA 1425

Query: 184  INGVDVQ--NREEAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSENEGE 241
            +NGV ++    ++AV  L +     + LL+ + +S  +K          L D  ++ +G 
Sbjct: 1426 VNGVSLEGATHKQAVETL-RNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGP 1484

Query: 242  LRARK 246
             + +K
Sbjct: 1485 EKVKK 1489



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 5/90 (5%)

Query: 125  ELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQI 184
            ELE E +     S +  LG  V   T   + +G YV +V  +  A  DGR++ GDR+I++
Sbjct: 1787 ELEVELLITLIKSEKGSLGFTV---TKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKV 1842

Query: 185  NGVDVQNREEAVAI-LSQEENTNISLLVAR 213
            N  DV N     A+ L +  +  + L++ R
Sbjct: 1843 NDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1872



 Score = 37.7 bits (86), Expect = 0.041
 Identities = 20/72 (27%), Positives = 40/72 (55%), Gaps = 1/72 (1%)

Query: 119  EADRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREG 178
            E  R+  L +   ++  + ++++LG  +C   D    + +Y+ ++NP S+AA +G ++  
Sbjct: 1875 ELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQV-VYISDINPRSVAAIEGNLQLL 1933

Query: 179  DRIIQINGVDVQ 190
            D I  +NGV  Q
Sbjct: 1934 DVIHYVNGVSTQ 1945



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 40/199 (20%), Positives = 86/199 (43%), Gaps = 36/199 (18%)

Query: 130  EVELYKSSHRDKLGLMVCYRTDDE---EDLG---IYVGEVNPNSIAAKDGRIREGDRIIQ 183
            EV+L+K+S     GL   +  +D    E +    + V ++ P   AA+ G+I  GD I++
Sbjct: 1506 EVKLFKNSS----GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1561

Query: 184  INGVDVQ--NREEAVAILS------------------QEENTNISLLVARPESQLAKRWK 223
            +NG  ++  +++E ++ L                    E +T +   +  P   L    K
Sbjct: 1562 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSK 1621

Query: 224  DSDRDDFLDDFGSENEGEL--RARKLKSPPAQQPGNEEEKGAPD----AGPGLSNSQELD 277
            DS +   ++   S +E E+  +++K    P+++    +  G+ +      P   ++    
Sbjct: 1622 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1681

Query: 278  SGVGRTDESTRNEESSEHD 296
            S + +T  +  ++  S H+
Sbjct: 1682 SALHQTLSNMVSQAQSHHE 1700



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 17/38 (44%), Positives = 24/38 (63%), Gaps = 1/38 (2%)

Query: 17   VMLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSP 54
            V+L+VNG  L  LSQ++ + ALR +  P V  +L R P
Sbjct: 1558 VILKVNGASLKGLSQQEVISALRGT-APEVFLLLCRPP 1594


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
           isoform 3 [Homo sapiens]
          Length = 2294

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 21/67 (31%), Positives = 41/67 (61%), Gaps = 1/67 (1%)

Query: 155 DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVAI-LSQEENTNISLLVAR 213
           DLGI++  V P   A  DG ++ GDR+I +N V ++      AI + Q    +++L++++
Sbjct: 927 DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 986

Query: 214 PESQLAK 220
           P+ +++K
Sbjct: 987 PKEKISK 993



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 36/120 (30%), Positives = 59/120 (49%), Gaps = 6/120 (5%)

Query: 130  EVELYKSSHRDKLGLMVCYRTDDE-EDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVD 188
            EVEL K+ +   LG+ V    +      GIYV  V P   A  DGRI +GDR++ +NGV 
Sbjct: 1177 EVELAKNDN--SLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1234

Query: 189  VQ--NREEAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSENEGELRARK 246
            ++    ++AV  L +     + LL+ + +S  +K          L D  ++ +G  + +K
Sbjct: 1235 LEGATHKQAVETL-RNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKK 1293



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 5/90 (5%)

Query: 125  ELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQI 184
            ELE E +     S +  LG  V   T   + +G YV +V  +  A  DGR++ GDR+I++
Sbjct: 1591 ELEVELLITLIKSEKGSLGFTV---TKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKV 1646

Query: 185  NGVDVQNREEAVAI-LSQEENTNISLLVAR 213
            N  DV N     A+ L +  +  + L++ R
Sbjct: 1647 NDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1676



 Score = 37.7 bits (86), Expect = 0.041
 Identities = 20/72 (27%), Positives = 40/72 (55%), Gaps = 1/72 (1%)

Query: 119  EADRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREG 178
            E  R+  L +   ++  + ++++LG  +C   D    + +Y+ ++NP S+AA +G ++  
Sbjct: 1679 ELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQV-VYISDINPRSVAAIEGNLQLL 1737

Query: 179  DRIIQINGVDVQ 190
            D I  +NGV  Q
Sbjct: 1738 DVIHYVNGVSTQ 1749



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 40/199 (20%), Positives = 86/199 (43%), Gaps = 36/199 (18%)

Query: 130  EVELYKSSHRDKLGLMVCYRTDDE---EDLG---IYVGEVNPNSIAAKDGRIREGDRIIQ 183
            EV+L+K+S     GL   +  +D    E +    + V ++ P   AA+ G+I  GD I++
Sbjct: 1310 EVKLFKNSS----GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1365

Query: 184  INGVDVQ--NREEAVAILS------------------QEENTNISLLVARPESQLAKRWK 223
            +NG  ++  +++E ++ L                    E +T +   +  P   L    K
Sbjct: 1366 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSK 1425

Query: 224  DSDRDDFLDDFGSENEGEL--RARKLKSPPAQQPGNEEEKGAPD----AGPGLSNSQELD 277
            DS +   ++   S +E E+  +++K    P+++    +  G+ +      P   ++    
Sbjct: 1426 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1485

Query: 278  SGVGRTDESTRNEESSEHD 296
            S + +T  +  ++  S H+
Sbjct: 1486 SALHQTLSNMVSQAQSHHE 1504



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 17/38 (44%), Positives = 24/38 (63%), Gaps = 1/38 (2%)

Query: 17   VMLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSP 54
            V+L+VNG  L  LSQ++ + ALR +  P V  +L R P
Sbjct: 1362 VILKVNGASLKGLSQQEVISALRGT-APEVFLLLCRPP 1398


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 21/67 (31%), Positives = 41/67 (61%), Gaps = 1/67 (1%)

Query: 155  DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVAI-LSQEENTNISLLVAR 213
            DLGI++  V P   A  DG ++ GDR+I +N V ++      AI + Q    +++L++++
Sbjct: 1118 DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1177

Query: 214  PESQLAK 220
            P+ +++K
Sbjct: 1178 PKEKISK 1184



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 36/120 (30%), Positives = 59/120 (49%), Gaps = 6/120 (5%)

Query: 130  EVELYKSSHRDKLGLMVCYRTDDE-EDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVD 188
            EVEL K+ +   LG+ V    +      GIYV  V P   A  DGRI +GDR++ +NGV 
Sbjct: 1368 EVELAKNDN--SLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1425

Query: 189  VQ--NREEAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSENEGELRARK 246
            ++    ++AV  L +     + LL+ + +S  +K          L D  ++ +G  + +K
Sbjct: 1426 LEGATHKQAVETL-RNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKK 1484



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 5/90 (5%)

Query: 125  ELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQI 184
            ELE E +     S +  LG  V   T   + +G YV +V  +  A  DGR++ GDR+I++
Sbjct: 1782 ELEVELLITLIKSEKGSLGFTV---TKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKV 1837

Query: 185  NGVDVQNREEAVAI-LSQEENTNISLLVAR 213
            N  DV N     A+ L +  +  + L++ R
Sbjct: 1838 NDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1867



 Score = 37.7 bits (86), Expect = 0.041
 Identities = 20/72 (27%), Positives = 40/72 (55%), Gaps = 1/72 (1%)

Query: 119  EADRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREG 178
            E  R+  L +   ++  + ++++LG  +C   D    + +Y+ ++NP S+AA +G ++  
Sbjct: 1870 ELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQV-VYISDINPRSVAAIEGNLQLL 1928

Query: 179  DRIIQINGVDVQ 190
            D I  +NGV  Q
Sbjct: 1929 DVIHYVNGVSTQ 1940



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 40/199 (20%), Positives = 86/199 (43%), Gaps = 36/199 (18%)

Query: 130  EVELYKSSHRDKLGLMVCYRTDDE---EDLG---IYVGEVNPNSIAAKDGRIREGDRIIQ 183
            EV+L+K+S     GL   +  +D    E +    + V ++ P   AA+ G+I  GD I++
Sbjct: 1501 EVKLFKNSS----GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1556

Query: 184  INGVDVQ--NREEAVAILS------------------QEENTNISLLVARPESQLAKRWK 223
            +NG  ++  +++E ++ L                    E +T +   +  P   L    K
Sbjct: 1557 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSK 1616

Query: 224  DSDRDDFLDDFGSENEGEL--RARKLKSPPAQQPGNEEEKGAPD----AGPGLSNSQELD 277
            DS +   ++   S +E E+  +++K    P+++    +  G+ +      P   ++    
Sbjct: 1617 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1676

Query: 278  SGVGRTDESTRNEESSEHD 296
            S + +T  +  ++  S H+
Sbjct: 1677 SALHQTLSNMVSQAQSHHE 1695



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 17/38 (44%), Positives = 24/38 (63%), Gaps = 1/38 (2%)

Query: 17   VMLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSP 54
            V+L+VNG  L  LSQ++ + ALR +  P V  +L R P
Sbjct: 1553 VILKVNGASLKGLSQQEVISALRGT-APEVFLLLCRPP 1589


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.131    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,272,754
Number of Sequences: 37866
Number of extensions: 1863910
Number of successful extensions: 9773
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 292
Number of HSP's that attempted gapping in prelim test: 8881
Number of HSP's gapped (non-prelim): 1153
length of query: 769
length of database: 18,247,518
effective HSP length: 110
effective length of query: 659
effective length of database: 14,082,258
effective search space: 9280208022
effective search space used: 9280208022
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.