Search of human proteins with 45643125

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
         (750 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                1479   0.0  
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                1479   0.0  
gi|6005942 valosin-containing protein [Homo sapiens]                  474   e-133
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              447   e-125
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       363   e-100
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           290   4e-78
gi|4505725 peroxin1 [Homo sapiens]                                    233   5e-61
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   185   1e-46
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   185   1e-46
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   185   1e-46
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]            178   1e-44
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           178   2e-44
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             176   9e-44
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     173   6e-43
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            172   1e-42
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               170   4e-42
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               170   4e-42
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            170   5e-42
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]              169   7e-42
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   169   7e-42
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            167   4e-41
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     159   7e-39
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                      154   3e-37
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                       154   3e-37
gi|31742536 fidgetin-like 1 [Homo sapiens]                            154   4e-37
gi|112789543 fidgetin-like 1 [Homo sapiens]                           154   4e-37
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]         150   3e-36
gi|40806170 spastin isoform 2 [Homo sapiens]                          149   7e-36
gi|11875211 spastin isoform 1 [Homo sapiens]                          149   7e-36
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     147   3e-35

>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score = 1479 bits (3829), Expect = 0.0
 Identities = 750/750 (100%), Positives = 750/750 (100%)

Query: 1   MEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPA 60
           MEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPA
Sbjct: 1   MEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPA 60

Query: 61  KDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNK 120
           KDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNK
Sbjct: 61  KDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNK 120

Query: 121 GSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRH 180
           GSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRH
Sbjct: 121 GSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRH 180

Query: 181 PEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKL 240
           PEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKL
Sbjct: 181 PEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKL 240

Query: 241 RELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLV 300
           RELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLV
Sbjct: 241 RELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLV 300

Query: 301 IGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLT 360
           IGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLT
Sbjct: 301 IGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLT 360

Query: 361 PGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQD 420
           PGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQD
Sbjct: 361 PGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQD 420

Query: 421 ELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGAL 480
           ELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGAL
Sbjct: 421 ELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGAL 480

Query: 481 EDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISV 540
           EDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISV
Sbjct: 481 EDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISV 540

Query: 541 KGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLL 600
           KGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLL
Sbjct: 541 KGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLL 600

Query: 601 TEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGT 660
           TEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGT
Sbjct: 601 TEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGT 660

Query: 661 KPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHK 720
           KPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHK
Sbjct: 661 KPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHK 720

Query: 721 HFEEAFKKVRSSISKKDQIMYERLQESLSR 750
           HFEEAFKKVRSSISKKDQIMYERLQESLSR
Sbjct: 721 HFEEAFKKVRSSISKKDQIMYERLQESLSR 750


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score = 1479 bits (3829), Expect = 0.0
 Identities = 750/750 (100%), Positives = 750/750 (100%)

Query: 1   MEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPA 60
           MEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPA
Sbjct: 107 MEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPA 166

Query: 61  KDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNK 120
           KDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNK
Sbjct: 167 KDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNK 226

Query: 121 GSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRH 180
           GSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRH
Sbjct: 227 GSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRH 286

Query: 181 PEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKL 240
           PEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKL
Sbjct: 287 PEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKL 346

Query: 241 RELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLV 300
           RELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLV
Sbjct: 347 RELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLV 406

Query: 301 IGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLT 360
           IGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLT
Sbjct: 407 IGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLT 466

Query: 361 PGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQD 420
           PGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQD
Sbjct: 467 PGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQD 526

Query: 421 ELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGAL 480
           ELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGAL
Sbjct: 527 ELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGAL 586

Query: 481 EDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISV 540
           EDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISV
Sbjct: 587 EDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISV 646

Query: 541 KGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLL 600
           KGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLL
Sbjct: 647 KGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLL 706

Query: 601 TEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGT 660
           TEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGT
Sbjct: 707 TEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGT 766

Query: 661 KPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHK 720
           KPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHK
Sbjct: 767 KPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHK 826

Query: 721 HFEEAFKKVRSSISKKDQIMYERLQESLSR 750
           HFEEAFKKVRSSISKKDQIMYERLQESLSR
Sbjct: 827 HFEEAFKKVRSSISKKDQIMYERLQESLSR 856


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  474 bits (1220), Expect = e-133
 Identities = 272/619 (43%), Positives = 374/619 (60%), Gaps = 67/619 (10%)

Query: 150 EFQISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLL 208
           E  ++ V ++D+GG    L ++ +M+ + +RHP ++  +GV PPRG+LL+GPPG GKTL+
Sbjct: 195 EESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLI 254

Query: 209 AHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKRE 268
           A A+A E       +  PEI+S ++GESE  LR+ FE+A  NAP IIFIDE+DAI PKRE
Sbjct: 255 ARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKRE 314

Query: 269 VASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGI 328
               ++ERRIV+QLLT MD L      A V+V+ ATNRP+S+DPALRR GRFDRE+ +GI
Sbjct: 315 KTHGEVERRIVSQLLTLMDGLKQ---RAHVIVMAATNRPNSIDPALRRFGRFDREVDIGI 371

Query: 329 PDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQ 388
           PD   R  ILQ   + ++L    D   +A+ T G VGADL ALC EAA+ A+        
Sbjct: 372 PDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAI-------- 423

Query: 389 EQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELN 448
              +K  ++ DL                              + + +  E M  L + ++
Sbjct: 424 ---RKKMDLIDL------------------------------EDETIDAEVMNSLAVTMD 450

Query: 449 DFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVT 508
           DF  ALS   PSA RE  V VP VTW DIG LED++ EL   +  PV +PD+F   G+  
Sbjct: 451 DFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTP 510

Query: 509 PAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSA 568
             GVL  GPPGCGKTLLAKA+ANE   NFIS+KGPELL M+ GESE  VR++F +A+ +A
Sbjct: 511 SKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAA 570

Query: 569 PCVIFFDEVDALCPRRSDR---ETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIID 625
           PCV+FFDE+D++   R        GA+ RV+NQ+LTEMDG+  ++ VFI+ ATNRPDIID
Sbjct: 571 PCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIID 630

Query: 626 PAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGA 685
           PAILRPGRLD+ +++ LP    R+AILK    N  K P+  DV+LE +A     + ++GA
Sbjct: 631 PAILRPGRLDQLIYIPLPDEKSRVAILKA---NLRKSPVAKDVDLEFLA--KMTNGFSGA 685

Query: 686 DLSAL--------VREASICALRQEMARQKSGN------EKGELKVSHKHFEEAFKKVRS 731
           DL+ +        +RE+    +R+E  RQ + +      +    ++   HFEEA +  R 
Sbjct: 686 DLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARR 745

Query: 732 SISKKDQIMYERLQESLSR 750
           S+S  D   YE   ++L +
Sbjct: 746 SVSDNDIRKYEMFAQTLQQ 764



 Score =  196 bits (499), Expect = 5e-50
 Identities = 108/260 (41%), Positives = 161/260 (61%), Gaps = 6/260 (2%)

Query: 444 CIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKA 503
           CI   D ++     +P  + +   ++  V + DIG       ++   +  P+R+P  FKA
Sbjct: 174 CIVAPDTVIHCEG-EPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKA 232

Query: 504 LGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQR 563
           +G+  P G+LL GPPG GKTL+A+AVANE+G  F  + GPE+++   GESE  +R+ F+ 
Sbjct: 233 IGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEE 292

Query: 564 AKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDI 623
           A+ +AP +IF DE+DA+ P+R         R+V+QLLT MDGL+ R  V +MAATNRP+ 
Sbjct: 293 AEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNS 352

Query: 624 IDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYT 683
           IDPA+ R GR D+ + +G+P    RL IL+  TKN     L  DV+LE +A +     + 
Sbjct: 353 IDPALRRFGRFDREVDIGIPDATGRLEILQIHTKN---MKLADDVDLEQVANETH--GHV 407

Query: 684 GADLSALVREASICALRQEM 703
           GADL+AL  EA++ A+R++M
Sbjct: 408 GADLAALCSEAALQAIRKKM 427


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  447 bits (1149), Expect = e-125
 Identities = 252/611 (41%), Positives = 375/611 (61%), Gaps = 65/611 (10%)

Query: 140 LQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLH 198
           + K +K +  +F+++   ++ +GG    LK + +++ + ++ PE++   G+  PRGVLL+
Sbjct: 337 IDKNSKEQDNQFKVT---YDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLY 393

Query: 199 GPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFID 258
           GPPG GKT++A A+A E+   +  +  PEI+S   GE+E KLR++F +A    P IIFID
Sbjct: 394 GPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFID 453

Query: 259 EIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAG 318
           E+DA+ PKRE A  ++E+R+VA LLT MD + +  +  +VLV+GATNRP +LD ALRR G
Sbjct: 454 ELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPG 513

Query: 319 RFDREICLGIPDEASRERILQTLCRKL-RLPQAFDFCHLAHLTPGFVGADLMALCREAAM 377
           RFD+EI +G+P+   R  ILQ L R++  L    +   LA+   G+VGADL  LC EA +
Sbjct: 514 RFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGL 573

Query: 378 CAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSE 437
           CA+ R+L       KK P + D+                       ++ GL++       
Sbjct: 574 CALRRIL-------KKQPNLPDV-----------------------KVAGLVK------- 596

Query: 438 EQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRN 497
                  I L DF+ A++ ++PSA RE  + VPNV+W+DIG LE I+ +L  A+  P+++
Sbjct: 597 -------ITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKH 649

Query: 498 PDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAV 557
           P+ F  +G+  P GVLL GPPGC KT++AKA+ANESGLNF+++KGPEL+N YVGESERAV
Sbjct: 650 PESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAV 709

Query: 558 RQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASV--RVVNQLLTEMDGLEARQQVFIM 615
           R+ F++A+  AP +IFFDE+DAL   R       +V  RV+ QLLTEMDG+E  + V I+
Sbjct: 710 RETFRKARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTIL 769

Query: 616 AATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAG 675
           AATNRPD ID A++RPGR+D+ ++V LP  A R  I K         P+  +V+L+ +  
Sbjct: 770 AATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKL---QFHSMPVSNEVDLDELI- 825

Query: 676 DLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISK 735
            L+ D Y+GA++ A+ REA++ AL +++             +  +HF +A   V   I +
Sbjct: 826 -LQTDAYSGAEIVAVCREAALLALEEDIQAN---------LIMKRHFTQALSTVTPRIPE 875

Query: 736 KDQIMYERLQE 746
             +  YE  QE
Sbjct: 876 SLRRFYEDYQE 886


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  363 bits (933), Expect = e-100
 Identities = 229/604 (37%), Positives = 339/604 (56%), Gaps = 99/604 (16%)

Query: 167 TLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAP 226
           +L+E+ ++   +R+P     LG+  PRGVLL GPPG GKT L  A+A E    +L V+AP
Sbjct: 211 SLRELLRL--PLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAP 268

Query: 227 EIVSGVSGESEQKLRELFEQA---VSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLL 283
            +     GE+E+ +R +F++A    S  P ++F+DE+DA+ P+R   S+  E R+VAQ+L
Sbjct: 269 ALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR--GSRAPESRVVAQVL 326

Query: 284 TCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCR 343
           T +D     +    V+V+GATNRPD+LDPALRR GRFDRE+ +G P    R+ ILQ +  
Sbjct: 327 TLLD---GASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITS 383

Query: 344 KLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSK 403
           K+ +    D   LA +T G+VGADL ALCREAAM A+        E+ + NP +      
Sbjct: 384 KMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLH-----SEKNQDNPVI------ 432

Query: 404 GVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKR 463
                           DE+                          DF+ A  ++QPS+ R
Sbjct: 433 ----------------DEI--------------------------DFLEAFKNIQPSSFR 450

Query: 464 E--GFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCG 521
              G + +  V W +IG LED++ +L  +I  P++ P +F  +GL  P GVLL GPPGC 
Sbjct: 451 SVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCA 510

Query: 522 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC 581
           KT L +A+A     +F+SV G +L + +VG+SE+ + Q+F++A+ S P ++F DE+D++ 
Sbjct: 511 KTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSIL 570

Query: 582 PRRSDRETGASV--RVVNQLLTEMDGLEAR--------------QQVF-----IMAATNR 620
             RS  +TG  V  RV++ LL E+DG+  +              Q+VF     I+AATNR
Sbjct: 571 GARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNR 630

Query: 621 PDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCD 680
           PD++D A+LRPGRLDK +++  P    RL+ILK  TK     P+  DV+LE +A +  C 
Sbjct: 631 PDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKT---MPIGPDVSLENLAAE-TC- 685

Query: 681 CYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIM 740
            ++GADL  L  EA++ AL++        N      V  +HF ++ K V+ S+S KD  +
Sbjct: 686 FFSGADLRNLCTEAALLALQE--------NGLDATTVKQEHFLKSLKTVKPSLSCKDLAL 737

Query: 741 YERL 744
           YE L
Sbjct: 738 YENL 741



 Score =  177 bits (449), Expect = 3e-44
 Identities = 108/259 (41%), Positives = 148/259 (57%), Gaps = 16/259 (6%)

Query: 477 IGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLN 536
           +G L +  + L   +  P+R P    ALGL  P GVLLAGPPG GKT L +AVA E+G  
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261

Query: 537 FISVKGPELLNMYVGESERAVRQVFQRAKNSA---PCVIFFDEVDALCPRRSDRETGASV 593
            ++V  P L     GE+E  VR+VFQRA+  A   P ++F DE+DALCP+R  R      
Sbjct: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSR--APES 319

Query: 594 RVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILK 653
           RVV Q+LT +DG    ++V ++ ATNRPD +DPA+ RPGR D+ + +G P    R  IL+
Sbjct: 320 RVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQ 379

Query: 654 TITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKG 713
            IT   +K P+ + V+L  +A       Y GADL+AL REA++ AL      Q +     
Sbjct: 380 VIT---SKMPISSHVDLGLLAE--MTVGYVGADLTALCREAAMHALLHSEKNQDNP---- 430

Query: 714 ELKVSHKHFEEAFKKVRSS 732
              +    F EAFK ++ S
Sbjct: 431 --VIDEIDFLEAFKNIQPS 447



 Score =  133 bits (334), Expect = 7e-31
 Identities = 88/248 (35%), Positives = 132/248 (53%), Gaps = 21/248 (8%)

Query: 153 ISNVKFEDVGG-NDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHA 211
           I  V +E++GG  D+ LK    +   ++ P  +  +G+  P+GVLL+GPPGC KT L  A
Sbjct: 458 IKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRA 517

Query: 212 IAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVAS 271
           +A       + V+  ++ S   G+SE+ L ++F QA ++ P I+F+DEID+I   R  AS
Sbjct: 518 LATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARS-AS 576

Query: 272 K---DMERRIVAQLLTCMDDLNNVAATAR----------------VLVIGATNRPDSLDP 312
           K   D++ R+++ LL  +D +       R                V++I ATNRPD LD 
Sbjct: 577 KTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDT 636

Query: 313 ALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALC 372
           AL R GR D+ I +  PD   R  IL+   + + +       +LA  T  F GADL  LC
Sbjct: 637 ALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLC 696

Query: 373 REAAMCAV 380
            EAA+ A+
Sbjct: 697 TEAALLAL 704


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  290 bits (741), Expect = 4e-78
 Identities = 201/566 (35%), Positives = 299/566 (52%), Gaps = 64/566 (11%)

Query: 195 VLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCI 254
           VLL GPPGCGKT +  A    L L +LKV    + +  SG  E KL+ +F +A    P +
Sbjct: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525

Query: 255 IFIDEIDAITPKREVASKDME-RRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPA 313
           + +  +D +   R+   +D     ++  LL   D LN+      ++V+  T+R   L   
Sbjct: 526 LLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPP---LMVVATTSRAQDLPAD 582

Query: 314 LRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCR 373
           ++ A  F  E+ +    E  R  IL+ L   L L Q  +   LA    GFV  DL AL  
Sbjct: 583 VQTA--FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLT 640

Query: 374 EAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQD 433
            ++  A  R+         KN  +    + G+ EE  G                      
Sbjct: 641 HSSRAACTRI---------KNSGL----AGGLTEEDEG---------------------- 665

Query: 434 PLSEEQMQGLCIELNDFIVALSSVQPS-AKREGFVTVPNVTWADIGALEDIREELTMAIL 492
              E    G  +   DF  AL  +Q + ++  G   +P+V+W D+G L+++++E+   I 
Sbjct: 666 ---ELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQ 722

Query: 493 APVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGE 552
            P+ +P+   +LGL   +G+LL GPPG GKTLLAKAVA E  L F+SVKGPEL+NMYVG+
Sbjct: 723 LPLEHPELL-SLGL-RRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQ 780

Query: 553 SERAVRQVFQRAKNSAPCVIFFDEVDALCPR--RSDRETGASVRVVNQLLTEMDGLEARQ 610
           SE  VR+VF RA+ +APC+IFFDE+D+L P   RS    G   RVV+QLL E+DGL + Q
Sbjct: 781 SEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQ 840

Query: 611 QVFIMAATNRPDIIDPAILRPGRLDKTLFVGL-PPPADRLAILKTITKNGTKPPLDADVN 669
            VF++ ATNRPD++DPA+LRPGR DK +FVG     A +L +L  IT+     P  + VN
Sbjct: 841 DVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVN 900

Query: 670 LEAIAGDLRCDC----YTGADLSALVREASICALRQEMARQKSGNEKGE--LKVSHKHFE 723
           +         DC     TGADL +L  +A   AL++ +   + G E G   L ++ +   
Sbjct: 901 V--------LDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALMLTMEDLL 952

Query: 724 EAFKKVRSSISKKDQIMYERLQESLS 749
           +A  +++ S+S+++ + Y+R+Q   +
Sbjct: 953 QAAARLQPSVSEQELLRYKRIQRKFA 978



 Score =  167 bits (423), Expect = 3e-41
 Identities = 108/277 (38%), Positives = 161/277 (58%), Gaps = 10/277 (3%)

Query: 152 QISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAH 210
           +I +V + DVGG     KE+ + + + + HPE+   LG+    G+LLHGPPG GKTLLA 
Sbjct: 698 KIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLS-LGL-RRSGLLLHGPPGTGKTLLAK 755

Query: 211 AIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVA 270
           A+A E  L  L V  PE+++   G+SE+ +RE+F +A + APCIIF DE+D++ P R  +
Sbjct: 756 AVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRS 815

Query: 271 --SKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGI 328
             S  +  R+V+QLL  +D L+   +T  V VIGATNRPD LDPAL R GRFD+ + +G 
Sbjct: 816 GDSGGVMDRVVSQLLAELDGLH---STQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGA 872

Query: 329 -PDEASRERILQTLCRKLRLPQAFDFCH-LAHLTPGFVGADLMALCREAAMCAVNRVLMK 386
             D AS+ R+L  + RK +L  +    + L    P   GADL +LC +A   A+ R +  
Sbjct: 873 NEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHD 932

Query: 387 LQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQ 423
           L+E  +       L  + + +     +P+   Q+ L+
Sbjct: 933 LEEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLR 969



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 70/228 (30%), Positives = 102/228 (44%), Gaps = 14/228 (6%)

Query: 474 WADIG--ALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVAN 531
           W+ +    LE +  EL  A+L P   P      G    + VLL GPPGCGKT +  A  +
Sbjct: 430 WSSLSPPGLEALVSELC-AVLKPRLQPGGALLTGT---SSVLLRGPPGCGKTTVVAAACS 485

Query: 532 ESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGA 591
             GL+ + V    L     G  E  ++ +F RA+   P V+    VD L   R      A
Sbjct: 486 HLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA 545

Query: 592 SV-RVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLA 650
            V  V+  LL   D L +   + ++A T+R   + PA ++       L V       RL+
Sbjct: 546 RVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PADVQTA-FPHELEVPALSEGQRLS 603

Query: 651 ILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICA 698
           IL+ +T +    PL  +VNL  +A   RC  +   DL AL+  +S  A
Sbjct: 604 ILRALTAH---LPLGQEVNLAQLA--RRCAGFVVGDLYALLTHSSRAA 646


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  233 bits (594), Expect = 5e-61
 Identities = 173/524 (33%), Positives = 260/524 (49%), Gaps = 78/524 (14%)

Query: 195  VLLHGPPGCGKTLLAHAIAGE----LDLPILKVAAPEIVSGVSGESEQKLREL-FEQAVS 249
            +LL G  G GK+ LA AI  E    LD  + +V   + + G   E+ QK  E+ F +AV 
Sbjct: 595  LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDC-KALRGKRLENIQKTLEVAFSEAVW 653

Query: 250  NAPCIIFIDEIDAIT-----PKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGAT 304
              P ++ +D++D I      P+ E +   ++ + +A  L  M     ++  + V +I  +
Sbjct: 654  MQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIK-EFISMGSLVALIATS 712

Query: 305  NRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLP--------QAFDFCHL 356
                SL P L  A       C+      ++E+  + LC  ++             D  H+
Sbjct: 713  QSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHV 772

Query: 357  AHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTS 416
            A  T GFV  D   L   A    ++R  +  +E+                          
Sbjct: 773  AKETGGFVARDFTVLVDRAIHSRLSRQSISTREK-------------------------- 806

Query: 417  ETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVP-NVTWA 475
                                      L +   DF  AL    P++ R   +  P ++ W 
Sbjct: 807  --------------------------LVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWD 840

Query: 476  DIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGL 535
             IG L ++R+ L   I  P + P+ F  L +    G+LL GPPG GKTLLA  +A ES +
Sbjct: 841  KIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRM 900

Query: 536  NFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRV 595
            NFISVKGPELL+ Y+G SE+AVR +F RA+ + PC++FFDE +++ PRR    TG + RV
Sbjct: 901  NFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRV 960

Query: 596  VNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTI 655
            VNQLLT++DG+E  Q V+++AAT+RPD+IDPA+LRPGRLDK ++    PP D+++ L+ +
Sbjct: 961  VNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYC---PPPDQVSRLEIL 1017

Query: 656  TKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICAL 699
                   PL  DV+L+ +A     D +TGADL AL+  A + AL
Sbjct: 1018 NVLSDSLPLADDVDLQHVAS--VTDSFTGADLKALLYNAQLEAL 1059



 Score =  151 bits (381), Expect = 2e-36
 Identities = 87/222 (39%), Positives = 128/222 (57%), Gaps = 3/222 (1%)

Query: 179  RHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQ 238
            ++PE++ +L +    G+LL+GPPG GKTLLA  IA E  +  + V  PE++S   G SEQ
Sbjct: 861  KYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQ 920

Query: 239  KLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARV 298
             +R++F +A +  PCI+F DE ++I P+R   +  +  R+V QLLT +D +  +     V
Sbjct: 921  AVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQG---V 977

Query: 299  LVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAH 358
             V+ AT+RPD +DPAL R GR D+ +    PD+ SR  IL  L   L L    D  H+A 
Sbjct: 978  YVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVAS 1037

Query: 359  LTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDL 400
            +T  F GADL AL   A + A++ +L+    Q   +    DL
Sbjct: 1038 VTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDL 1079



 Score = 30.0 bits (66), Expect = 8.2
 Identities = 23/105 (21%), Positives = 46/105 (43%), Gaps = 14/105 (13%)

Query: 485 EELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANES---------GL 535
           E +T ++L    +      +  +    +LL G  G GK+ LAKA+  E+          +
Sbjct: 568 EHITHSLLGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERV 627

Query: 536 NFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDAL 580
           +  +++G  L N+     ++ +   F  A    P V+  D++D +
Sbjct: 628 DCKALRGKRLENI-----QKTLEVAFSEAVWMQPSVVLLDDLDLI 667


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  185 bits (470), Expect = 1e-46
 Identities = 108/276 (39%), Positives = 166/276 (60%), Gaps = 23/276 (8%)

Query: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAV 529
           P+V +ADIG ++  ++E+  A+  P+ + + +K +G+  P GVL+ GPPGCGKT+LAKAV
Sbjct: 156 PDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAV 215

Query: 530 ANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589
           A+ +   FI V G E +  Y+GE  R VR VF+ AK +AP +IF DE+DA+  +R D +T
Sbjct: 216 AHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQT 275

Query: 590 GAS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPA 646
           GA     R++ +LL +MDG +    V ++ ATNR D +DPA+LRPGRLD+ +   LP   
Sbjct: 276 GADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRR 335

Query: 647 DRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQ 706
            +  I  TIT   +K  L  +V+LE      R D  +GAD++++ +E+ + A+R+     
Sbjct: 336 QKRLIFSTIT---SKMNLSEEVDLEDYVA--RPDKISGADINSICQESGMLAVRE----- 385

Query: 707 KSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYE 742
                     V  K FE+A+K    ++ KKD+  +E
Sbjct: 386 ------NRYIVLAKDFEKAYK----TVIKKDEQEHE 411



 Score =  167 bits (424), Expect = 3e-41
 Identities = 94/244 (38%), Positives = 139/244 (56%), Gaps = 3/244 (1%)

Query: 152 QISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAH 210
           Q  +V + D+GG D+  +EV + + + + H E+Y  +G+ PPRGVL++GPPGCGKT+LA 
Sbjct: 154 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 213

Query: 211 AIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVA 270
           A+A       ++V   E V    GE  + +R++F  A  NAP IIFIDEIDAI  KR  A
Sbjct: 214 AVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDA 273

Query: 271 SKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPD 330
               +R +   LL  ++ ++       V VI ATNR D+LDPAL R GR DR+I   +PD
Sbjct: 274 QTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPD 333

Query: 331 EASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAV--NRVLMKLQ 388
              +  I  T+  K+ L +  D            GAD+ ++C+E+ M AV  NR ++  +
Sbjct: 334 RRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAK 393

Query: 389 EQQK 392
           + +K
Sbjct: 394 DFEK 397


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  185 bits (470), Expect = 1e-46
 Identities = 108/276 (39%), Positives = 166/276 (60%), Gaps = 23/276 (8%)

Query: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAV 529
           P+V +ADIG ++  ++E+  A+  P+ + + +K +G+  P GVL+ GPPGCGKT+LAKAV
Sbjct: 129 PDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAV 188

Query: 530 ANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589
           A+ +   FI V G E +  Y+GE  R VR VF+ AK +AP +IF DE+DA+  +R D +T
Sbjct: 189 AHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQT 248

Query: 590 GAS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPA 646
           GA     R++ +LL +MDG +    V ++ ATNR D +DPA+LRPGRLD+ +   LP   
Sbjct: 249 GADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRR 308

Query: 647 DRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQ 706
            +  I  TIT   +K  L  +V+LE      R D  +GAD++++ +E+ + A+R+     
Sbjct: 309 QKRLIFSTIT---SKMNLSEEVDLEDYVA--RPDKISGADINSICQESGMLAVRE----- 358

Query: 707 KSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYE 742
                     V  K FE+A+K    ++ KKD+  +E
Sbjct: 359 ------NRYIVLAKDFEKAYK----TVIKKDEQEHE 384



 Score =  167 bits (424), Expect = 3e-41
 Identities = 94/244 (38%), Positives = 139/244 (56%), Gaps = 3/244 (1%)

Query: 152 QISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAH 210
           Q  +V + D+GG D+  +EV + + + + H E+Y  +G+ PPRGVL++GPPGCGKT+LA 
Sbjct: 127 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 186

Query: 211 AIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVA 270
           A+A       ++V   E V    GE  + +R++F  A  NAP IIFIDEIDAI  KR  A
Sbjct: 187 AVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDA 246

Query: 271 SKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPD 330
               +R +   LL  ++ ++       V VI ATNR D+LDPAL R GR DR+I   +PD
Sbjct: 247 QTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPD 306

Query: 331 EASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAV--NRVLMKLQ 388
              +  I  T+  K+ L +  D            GAD+ ++C+E+ M AV  NR ++  +
Sbjct: 307 RRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAK 366

Query: 389 EQQK 392
           + +K
Sbjct: 367 DFEK 370


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  185 bits (470), Expect = 1e-46
 Identities = 108/276 (39%), Positives = 166/276 (60%), Gaps = 23/276 (8%)

Query: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAV 529
           P+V +ADIG ++  ++E+  A+  P+ + + +K +G+  P GVL+ GPPGCGKT+LAKAV
Sbjct: 160 PDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAV 219

Query: 530 ANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589
           A+ +   FI V G E +  Y+GE  R VR VF+ AK +AP +IF DE+DA+  +R D +T
Sbjct: 220 AHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQT 279

Query: 590 GAS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPA 646
           GA     R++ +LL +MDG +    V ++ ATNR D +DPA+LRPGRLD+ +   LP   
Sbjct: 280 GADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRR 339

Query: 647 DRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQ 706
            +  I  TIT   +K  L  +V+LE      R D  +GAD++++ +E+ + A+R+     
Sbjct: 340 QKRLIFSTIT---SKMNLSEEVDLEDYVA--RPDKISGADINSICQESGMLAVRE----- 389

Query: 707 KSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYE 742
                     V  K FE+A+K    ++ KKD+  +E
Sbjct: 390 ------NRYIVLAKDFEKAYK----TVIKKDEQEHE 415



 Score =  167 bits (424), Expect = 3e-41
 Identities = 94/244 (38%), Positives = 139/244 (56%), Gaps = 3/244 (1%)

Query: 152 QISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAH 210
           Q  +V + D+GG D+  +EV + + + + H E+Y  +G+ PPRGVL++GPPGCGKT+LA 
Sbjct: 158 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 217

Query: 211 AIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVA 270
           A+A       ++V   E V    GE  + +R++F  A  NAP IIFIDEIDAI  KR  A
Sbjct: 218 AVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDA 277

Query: 271 SKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPD 330
               +R +   LL  ++ ++       V VI ATNR D+LDPAL R GR DR+I   +PD
Sbjct: 278 QTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPD 337

Query: 331 EASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAV--NRVLMKLQ 388
              +  I  T+  K+ L +  D            GAD+ ++C+E+ M AV  NR ++  +
Sbjct: 338 RRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAK 397

Query: 389 EQQK 392
           + +K
Sbjct: 398 DFEK 401


>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
          Length = 797

 Score =  178 bits (452), Expect = 1e-44
 Identities = 107/277 (38%), Positives = 157/277 (56%), Gaps = 24/277 (8%)

Query: 471 NVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVA 530
           +V + D+   E+ + E+ M  +  ++NP Q++ LG   P G +L GPPG GKTLLAKA A
Sbjct: 304 DVKFKDVAGCEEAKLEI-MEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATA 362

Query: 531 NESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG 590
            E+ + FI+V G E L M+VG     VR +F  A+ +APC++F DE+DA+  +R     G
Sbjct: 363 GEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFG 422

Query: 591 A---SVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPAD 647
                   +NQLL EMDG      V I+A TNRPDI+DPA+LRPGR D+ +F+G P    
Sbjct: 423 GQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKG 482

Query: 648 RLAILKTITKNGTKPPLDADVNLE--AIAGDLR--CDCYTGADLSALVREASICALRQEM 703
           R +I K   +     PL  D  LE   +A  L      ++GAD++ +  EA++ A     
Sbjct: 483 RASIFKVHLR-----PLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIA----- 532

Query: 704 ARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIM 740
           AR  S +      ++ KHFE+A ++V   + KK Q++
Sbjct: 533 ARHLSDS------INQKHFEQAIERVIGGLEKKTQVL 563



 Score =  172 bits (435), Expect = 1e-42
 Identities = 98/236 (41%), Positives = 135/236 (57%), Gaps = 10/236 (4%)

Query: 155 NVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAG 214
           +VKF+DV G +    E+ + +  +++P+ Y  LG   P+G +L GPPG GKTLLA A AG
Sbjct: 304 DVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAG 363

Query: 215 ELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKR---EVAS 271
           E ++P + V+  E +    G    ++R+LF  A  NAPCI+FIDEIDA+  KR       
Sbjct: 364 EANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGG 423

Query: 272 KDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDE 331
           +  +   + QLL  MD  N    T  V+++  TNRPD LDPAL R GRFDR+I +G PD 
Sbjct: 424 QSEQENTLNQLLVEMDGFN---TTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDI 480

Query: 332 ASRERILQTLCRKLRLPQAFD----FCHLAHLTPGFVGADLMALCREAAMCAVNRV 383
             R  I +   R L+L    +       LA LTPGF GAD+  +C EAA+ A   +
Sbjct: 481 KGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHL 536


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  178 bits (451), Expect = 2e-44
 Identities = 99/239 (41%), Positives = 147/239 (61%), Gaps = 16/239 (6%)

Query: 471 NVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVA 530
           NV++++IG L +   EL   I  P+ NP+ F+ +G++ P G LL GPPG GKTLLA+AVA
Sbjct: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202

Query: 531 NESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG 590
           ++   NF+ V    +++ Y+GES R +R++F  A++  PC+IF DE+DA+  RR    T 
Sbjct: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262

Query: 591 AS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPAD 647
           A     R + +LL +MDG +   +V ++ ATNRPD +DPA+LRPGRLD+ + + LP    
Sbjct: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322

Query: 648 RLAILK----TITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQE 702
           RL ILK     ITK+G       +++ EAI      D + GADL  +  EA + A+R +
Sbjct: 323 RLDILKIHAGPITKHG-------EIDYEAIV--KLSDGFNGADLRNVCTEAGMFAIRAD 372



 Score =  174 bits (441), Expect = 3e-43
 Identities = 92/227 (40%), Positives = 140/227 (61%), Gaps = 1/227 (0%)

Query: 155 NVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIA 213
           NV + ++GG    ++E+ +++ + + +PE++  +G++PP+G LL+GPPG GKTLLA A+A
Sbjct: 143 NVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA 202

Query: 214 GELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKD 273
            +LD   LKV +  IV    GES + +RE+F  A  + PCIIF+DEIDAI  +R      
Sbjct: 203 SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 262

Query: 274 MERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEAS 333
            +R I   L+  ++ ++      RV +I ATNRPD+LDPAL R GR DR+I + +P+E +
Sbjct: 263 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQA 322

Query: 334 RERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAV 380
           R  IL+     +      D+  +  L+ GF GADL  +C EA M A+
Sbjct: 323 RLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAI 369


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  176 bits (445), Expect = 9e-44
 Identities = 104/269 (38%), Positives = 156/269 (57%), Gaps = 19/269 (7%)

Query: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAV 529
           P+VT++D+G  ++  E+L   +  P+ +P++F  LG+  P GVLL GPPG GKTL A+AV
Sbjct: 170 PDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAV 229

Query: 530 ANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589
           AN +   FI V G EL+  YVGE  R VR++F+ A+    C+IFFDE+DA+   R D   
Sbjct: 230 ANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGA 289

Query: 590 GAS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPA 646
           G      R + +L+ ++DG + R  + ++ ATNRPD +DPA++RPGRLD+ +   LP   
Sbjct: 290 GGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLE 349

Query: 647 DRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQ 706
            R  I K   ++ +   ++ D+  E +A    C   TGA++ ++  EA + A+R   AR+
Sbjct: 350 GRTHIFKIHARSMS---VERDIRFELLA--RLCPNSTGAEIRSVCTEAGMFAIR---ARR 401

Query: 707 KSGNEKGELKVSHKHFEEAFKKVRSSISK 735
           K   E        K F EA  KV  S +K
Sbjct: 402 KIATE--------KDFLEAVNKVIKSYAK 422



 Score =  155 bits (391), Expect = 2e-37
 Identities = 86/227 (37%), Positives = 128/227 (56%), Gaps = 1/227 (0%)

Query: 155 NVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIA 213
           +V + DVGG    ++++ +++   + HPE + +LG+ PP+GVLL GPPG GKTL A A+A
Sbjct: 171 DVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVA 230

Query: 214 GELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKD 273
              D   ++V   E+V    GE  + +RELFE A +   C+IF DEIDAI   R      
Sbjct: 231 NRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAG 290

Query: 274 MERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEAS 333
            +  +   +L  ++ L+       + V+ ATNRPD+LDPAL R GR DR+I   +PD   
Sbjct: 291 GDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEG 350

Query: 334 RERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAV 380
           R  I +   R + + +   F  LA L P   GA++ ++C EA M A+
Sbjct: 351 RTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAI 397


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  173 bits (438), Expect = 6e-43
 Identities = 112/314 (35%), Positives = 172/314 (54%), Gaps = 22/314 (7%)

Query: 86  CEKSNPKKPITEIQDSKDSSLLESDM---KRKGKLKNKGSKR------KKEDLQEVDGEI 136
           C++ N ++      DS  SS  E +    +R+ + +N+   R      +K++L+ +  + 
Sbjct: 345 CKRMNRRRHAIHSSDSTSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDR 404

Query: 137 EAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIH-MRHPEVYHHLGVVPPRGV 195
             +    A    ++   S+V+F+ VGG    +  + +M++  + +PEV+    + PPRG 
Sbjct: 405 MKIGASLADVDPMQLD-SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGC 463

Query: 196 LLHGPPGCGKTLLAHAIAGELDLPILKVA-----APEIVSGVSGESEQKLRELFEQAVSN 250
           L +GPPG GKTL+A A+A E      +VA       + +S   GESE++LR LF+QA   
Sbjct: 464 LFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQM 523

Query: 251 APCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSL 310
            P IIF DEID + P R      +   IV+ LL  MD L++      ++VIGATNR DS+
Sbjct: 524 RPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDS---RGEIVVIGATNRLDSI 580

Query: 311 DPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFD--FCHLAHLTPGFVGADL 368
           DPALRR GRFDRE    +PD+ +R+ IL+   R    P+  D     LA    G+ GAD+
Sbjct: 581 DPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWN-PKPLDTFLEELAENCVGYCGADI 639

Query: 369 MALCREAAMCAVNR 382
            ++C EAA+CA+ R
Sbjct: 640 KSICAEAALCALRR 653



 Score =  171 bits (434), Expect = 2e-42
 Identities = 102/269 (37%), Positives = 152/269 (56%), Gaps = 14/269 (5%)

Query: 471 NVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVA 530
           +V +  +G L +    L   ++ P+  P+ F+   +  P G L  GPPG GKTL+A+A+A
Sbjct: 422 SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALA 481

Query: 531 NESG-----LNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRS 585
           NE       + F   KG + L+ +VGESER +R +F +A    P +IFFDE+D L P RS
Sbjct: 482 NECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRS 541

Query: 586 DRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPP 645
            R+      +V+ LL  MDGL++R ++ ++ ATNR D IDPA+ RPGR D+     LP  
Sbjct: 542 SRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDK 601

Query: 646 ADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMAR 705
             R  ILK  T++    PL  D  LE +A +  C  Y GAD+ ++  EA++CALR+   +
Sbjct: 602 EARKEILKIHTRDWNPKPL--DTFLEELAEN--CVGYCGADIKSICAEAALCALRRRYPQ 657

Query: 706 QKSGNEK-----GELKVSHKHFEEAFKKV 729
             + +EK       + +S K FE A +K+
Sbjct: 658 IYTTSEKLQLDLSSINISAKDFEVAMQKM 686


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  172 bits (436), Expect = 1e-42
 Identities = 94/235 (40%), Positives = 140/235 (59%), Gaps = 1/235 (0%)

Query: 157 KFEDVGGNDMTLKEVCKMLI-HMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGE 215
           ++ D+GG D  ++E+ + ++  M H E + +LG+ PP+GVL++GPPG GKTLLA A A +
Sbjct: 184 QYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQ 243

Query: 216 LDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDME 275
                LK+A P++V    G+  + +R+ F  A   AP IIFIDE+DAI  KR  + K  +
Sbjct: 244 TKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGD 303

Query: 276 RRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRE 335
           R +   +L  ++ L+      +V VI ATNR D LDPAL R+GR DR+I   +P+E +R 
Sbjct: 304 REVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARA 363

Query: 336 RILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQ 390
           RI+Q   RK+ +    ++  LA  T  F GA   A+C EA M A+ R   +L  +
Sbjct: 364 RIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHE 418



 Score =  170 bits (431), Expect = 4e-42
 Identities = 101/276 (36%), Positives = 158/276 (57%), Gaps = 23/276 (8%)

Query: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAV 529
           P   ++DIG L+   +EL  AI+ P+ + ++F+ LG+  P GVL+ GPPG GKTLLA+A 
Sbjct: 181 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 240

Query: 530 ANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589
           A ++   F+ + GP+L+ M++G+  + VR  F  AK  AP +IF DE+DA+  +R D E 
Sbjct: 241 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 300

Query: 590 GAS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPA 646
                  R + +LL ++DG +   QV ++AATNR DI+DPA+LR GRLD+ +   +P   
Sbjct: 301 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE 360

Query: 647 DRLAILKTITKNGTKPPLDADVNLEAIAGDLRC-DCYTGADLSALVREASICALRQEMAR 705
            R  I++    +  K  +  DVN E +A   RC D + GA   A+  EA + ALR     
Sbjct: 361 ARARIMQI---HSRKMNVSPDVNYEELA---RCTDDFNGAQCKAVCVEAGMIALR----- 409

Query: 706 QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMY 741
                 +G  +++H+ + E   +V++   KK  + Y
Sbjct: 410 ------RGATELTHEDYMEGILEVQA--KKKANLQY 437


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  170 bits (431), Expect = 4e-42
 Identities = 112/289 (38%), Positives = 168/289 (58%), Gaps = 24/289 (8%)

Query: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGKTLLAKA 528
           P++ W DI  LE+ ++ L  A++ P+  PD FK  G+  P  GVL+ GPPG GKT+LAKA
Sbjct: 203 PSIHWDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKA 260

Query: 529 VANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRR-SDR 587
           VA E G  F +V    L + Y GESE+ VR +F+ A+  AP  IF DE+D++C RR +  
Sbjct: 261 VATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSD 320

Query: 588 ETGASVRVVNQLLTEMDGL-------EARQQVFIMAATNRPDIIDPAILRPGRLDKTLFV 640
           E  AS RV ++LL +MDG+       +  + V ++AATN P  ID A+ R  RL+K +++
Sbjct: 321 EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 378

Query: 641 GLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALR 700
            LP    R  +LK    N  +  LD D+ LE IA   + + Y+GAD++ + R+AS+ A+R
Sbjct: 379 PLPTAKGRAELLKI---NLREVELDPDIQLEDIAE--KIEGYSGADITNVCRDASLMAMR 433

Query: 701 QEM------ARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 743
           + +        +    E+ ++ V+   FE A KK+  S+S  D   YE+
Sbjct: 434 RRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEK 482



 Score =  123 bits (308), Expect = 7e-28
 Identities = 95/317 (29%), Positives = 163/317 (51%), Gaps = 23/317 (7%)

Query: 99  QDSKDSSLLESDMKRKGKLKNKGSKRKKE-----DLQEVDGEIEAVLQKKAKARGLEFQI 153
           +  K S+  + D + +G+  +KG K  ++     ++ + DG        +A  R +  + 
Sbjct: 144 KSEKPSTSRDKDYRARGR-DDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSRN 202

Query: 154 SNVKFEDVGGNDMTLKEVCKML-----IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLL 208
            ++ ++D+      L+E  K+L     + M  P+ +  +   P +GVL+ GPPG GKT+L
Sbjct: 203 PSIHWDDIAD----LEEAKKLLREAVVLPMWMPDFFKGIRR-PWKGVLMVGPPGTGKTML 257

Query: 209 AHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKRE 268
           A A+A E       V++  + S   GESE+ +R LFE A   AP  IFIDEID+I  +R 
Sbjct: 258 AKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRG 317

Query: 269 VASK-DMERRIVAQLLTCMDD----LNNVAATARVLVIGATNRPDSLDPALRRAGRFDRE 323
            + + +  RR+ ++LL  MD     L N   +  V+V+ ATN P  +D ALRR  R ++ 
Sbjct: 318 TSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKR 375

Query: 324 ICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRV 383
           I + +P    R  +L+   R++ L        +A    G+ GAD+  +CR+A++ A+ R 
Sbjct: 376 IYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRR 435

Query: 384 LMKLQEQQKKNPEMEDL 400
           +  L  ++ +    E+L
Sbjct: 436 INGLSPEEIRALSKEEL 452


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  170 bits (431), Expect = 4e-42
 Identities = 112/289 (38%), Positives = 168/289 (58%), Gaps = 24/289 (8%)

Query: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGKTLLAKA 528
           P++ W DI  LE+ ++ L  A++ P+  PD FK  G+  P  GVL+ GPPG GKT+LAKA
Sbjct: 203 PSIHWDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKA 260

Query: 529 VANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRR-SDR 587
           VA E G  F +V    L + Y GESE+ VR +F+ A+  AP  IF DE+D++C RR +  
Sbjct: 261 VATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSD 320

Query: 588 ETGASVRVVNQLLTEMDGL-------EARQQVFIMAATNRPDIIDPAILRPGRLDKTLFV 640
           E  AS RV ++LL +MDG+       +  + V ++AATN P  ID A+ R  RL+K +++
Sbjct: 321 EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 378

Query: 641 GLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALR 700
            LP    R  +LK    N  +  LD D+ LE IA   + + Y+GAD++ + R+AS+ A+R
Sbjct: 379 PLPTAKGRAELLKI---NLREVELDPDIQLEDIAE--KIEGYSGADITNVCRDASLMAMR 433

Query: 701 QEM------ARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 743
           + +        +    E+ ++ V+   FE A KK+  S+S  D   YE+
Sbjct: 434 RRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEK 482



 Score =  123 bits (308), Expect = 7e-28
 Identities = 95/317 (29%), Positives = 163/317 (51%), Gaps = 23/317 (7%)

Query: 99  QDSKDSSLLESDMKRKGKLKNKGSKRKKE-----DLQEVDGEIEAVLQKKAKARGLEFQI 153
           +  K S+  + D + +G+  +KG K  ++     ++ + DG        +A  R +  + 
Sbjct: 144 KSEKPSTSRDKDYRARGR-DDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSRN 202

Query: 154 SNVKFEDVGGNDMTLKEVCKML-----IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLL 208
            ++ ++D+      L+E  K+L     + M  P+ +  +   P +GVL+ GPPG GKT+L
Sbjct: 203 PSIHWDDIAD----LEEAKKLLREAVVLPMWMPDFFKGIRR-PWKGVLMVGPPGTGKTML 257

Query: 209 AHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKRE 268
           A A+A E       V++  + S   GESE+ +R LFE A   AP  IFIDEID+I  +R 
Sbjct: 258 AKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRG 317

Query: 269 VASK-DMERRIVAQLLTCMDD----LNNVAATARVLVIGATNRPDSLDPALRRAGRFDRE 323
            + + +  RR+ ++LL  MD     L N   +  V+V+ ATN P  +D ALRR  R ++ 
Sbjct: 318 TSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKR 375

Query: 324 ICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRV 383
           I + +P    R  +L+   R++ L        +A    G+ GAD+  +CR+A++ A+ R 
Sbjct: 376 IYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRR 435

Query: 384 LMKLQEQQKKNPEMEDL 400
           +  L  ++ +    E+L
Sbjct: 436 INGLSPEEIRALSKEEL 452


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  170 bits (430), Expect = 5e-42
 Identities = 93/245 (37%), Positives = 150/245 (61%), Gaps = 10/245 (4%)

Query: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAV 529
           P  T+ADIG L++  +E+  ++  P+ +P+ ++ +G+  P GV+L GPPG GKTLLAKAV
Sbjct: 180 PQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAV 239

Query: 530 ANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589
           AN++   F+ V G EL+  Y+G+  + VR++F+ A+  AP ++F DE+DA+  +R D  +
Sbjct: 240 ANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNS 299

Query: 590 GAS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPA 646
           G      R + +LL ++DG ++R  V ++ ATNR + +DPA++RPGR+D+ +   LP   
Sbjct: 300 GGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEK 359

Query: 647 DRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQ 706
            +  I +  T   T   L  DV L+ +   +  D  +GAD+ A+  EA + ALR+   R 
Sbjct: 360 TKKRIFQIHTSRMT---LADDVTLDDLI--MAKDDLSGADIKAICTEAGLMALRER--RM 412

Query: 707 KSGNE 711
           K  NE
Sbjct: 413 KVTNE 417



 Score =  167 bits (422), Expect = 4e-41
 Identities = 94/241 (39%), Positives = 140/241 (58%), Gaps = 2/241 (0%)

Query: 158 FEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGEL 216
           + D+GG D  ++E+ + + + + HPE Y  +G+ PP+GV+L+GPPG GKTLLA A+A + 
Sbjct: 184 YADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQT 243

Query: 217 DLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMER 276
               L+V   E++    G+  + +RELF  A  +AP I+FIDEIDAI  KR  ++   ER
Sbjct: 244 SATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGER 303

Query: 277 RIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRER 336
            I   +L  ++ L+   +   V VI ATNR ++LDPAL R GR DR+I   +PDE +++R
Sbjct: 304 EIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKR 363

Query: 337 ILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKL-QEQQKKNP 395
           I Q    ++ L        L        GAD+ A+C EA + A+    MK+  E  KK+ 
Sbjct: 364 IFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSK 423

Query: 396 E 396
           E
Sbjct: 424 E 424


>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
          Length = 795

 Score =  169 bits (429), Expect = 7e-42
 Identities = 97/230 (42%), Positives = 133/230 (57%), Gaps = 9/230 (3%)

Query: 156 VKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGE 215
           V F+DV G      EV + + +++ PE +  LG   P+G LL GPPGCGKTLLA A+A E
Sbjct: 306 VSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATE 365

Query: 216 LDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVA----S 271
             +P L +A PE V  + G    ++R LF++A + APCI++IDEIDA+  KR       S
Sbjct: 366 AQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFS 425

Query: 272 KDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDE 331
              E + + QLL  MD    +  T  V+V+ +TNR D LD AL R GR DR + + +P  
Sbjct: 426 NTEEEQTLNQLLVEMD---GMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTL 482

Query: 332 ASRERILQTLCRKLRLPQAFDFC--HLAHLTPGFVGADLMALCREAAMCA 379
             R  I +   + L+L Q+  F    LA LTPGF GAD+  +C EAA+ A
Sbjct: 483 QERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHA 532



 Score =  160 bits (404), Expect = 5e-39
 Identities = 95/279 (34%), Positives = 160/279 (57%), Gaps = 19/279 (6%)

Query: 472 VTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVAN 531
           V++ D+  + + + E+    +  +++P++F  LG   P G LL GPPGCGKTLLAKAVA 
Sbjct: 306 VSFKDVAGMHEAKLEVR-EFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364

Query: 532 ESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGA 591
           E+ + F+++ GPE + +  G     VR +F+ A+  APC+++ DE+DA+  +RS   +G 
Sbjct: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424

Query: 592 S----VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPAD 647
           S     + +NQLL EMDG+     V ++A+TNR DI+D A++RPGRLD+ +F+ LP   +
Sbjct: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484

Query: 648 RLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQK 707
           R  I +   K+  K    +    + +A       ++GAD++ +  EA++ A R+      
Sbjct: 485 RREIFEQHLKS-LKLTQSSTFYSQRLAE--LTPGFSGADIANICNEAALHAARE------ 535

Query: 708 SGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQE 746
                G   V   +FE A ++V +  +KK +I+ +  Q+
Sbjct: 536 -----GHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQK 569


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  169 bits (429), Expect = 7e-42
 Identities = 158/569 (27%), Positives = 251/569 (44%), Gaps = 87/569 (15%)

Query: 104 SSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIE----AVLQKKAKARGLEFQIS----- 154
           S    SD +R  + K+K   R +     ++   E     +L+++ K       +      
Sbjct: 335 SDTTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNID 394

Query: 155 -NVKFEDVGGNDMTLKEVCKMLIH-MRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAI 212
            +V+F+ +GG    +  + +M++  + +PE++    + PPRG L +GPPG GKTL+A A+
Sbjct: 395 KSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARAL 454

Query: 213 AGELDLPILKVA-----APEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKR 267
           A E      KVA       + +S   GESE++LR LF+QA    P IIF DEID + P R
Sbjct: 455 ANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVR 514

Query: 268 EVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLG 327
                 +   IV+ LL  MD L+N      ++VIGATNR DS+DPALRR GRFDRE    
Sbjct: 515 SSRQDQIHSSIVSTLLALMDGLDN---RGEIVVIGATNRLDSIDPALRRPGRFDREFLFN 571

Query: 328 IPDEASRERILQTLCR--KLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLM 385
           +PD+ +R+ ILQ   R    +L  AF    LA    G+ GAD+ ALC EAA+ A+ R   
Sbjct: 572 LPDQKARKHILQIHTRDWNPKLSDAF-LGELAEKCVGYCGADIKALCTEAALIALRRRYP 630

Query: 386 KLQEQQKK---NPEMEDLPSKGVQEERLGTEPTSE--TQDELQRLLGLLRDQDPLSEEQM 440
           ++     K   +     L ++          P S+         L  ++R   PL E   
Sbjct: 631 QIYASSHKLQLDVSSIVLSAQDFYHAMQNIVPASQRAVMSSGHALSPIIR---PLLERSF 687

Query: 441 QGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAI--------- 491
             +   L   +   + +  S K+E   T+          LED  +E  ++I         
Sbjct: 688 NNILAVLQK-VFPHAEISQSDKKEDIETL---------ILEDSEDENALSIFETNCHSGS 737

Query: 492 ------------------LAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTL-LAKAVANE 532
                             ++P   P  ++         +LL+G  G G+T  LA A+ + 
Sbjct: 738 PKKQSSSAAIHKPYLHFTMSPYHQPTSYR-------PRLLLSGERGSGQTSHLAPALLHT 790

Query: 533 SGLNFISVKG---PELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589
             L   SV     P L ++     E +  Q+F+ A+ + P +++        P   D   
Sbjct: 791 --LERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYM-------PHIGDWWE 841

Query: 590 GASVRVVNQLLTEMDGLEARQQVFIMAAT 618
             S  V    LT +  + +   +F+++ +
Sbjct: 842 AVSETVRATFLTLLQDIPSFSPIFLLSTS 870



 Score =  157 bits (397), Expect = 3e-38
 Identities = 98/255 (38%), Positives = 142/255 (55%), Gaps = 13/255 (5%)

Query: 471 NVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVA 530
           +V +  IG L      L   ++ P+  P+ F+   +  P G L  GPPG GKTL+A+A+A
Sbjct: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455

Query: 531 NESG-----LNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRS 585
           NE       + F   KG + L+ +VGESER +R +F +A    P +IFFDE+D L P RS
Sbjct: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515

Query: 586 DRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPP 645
            R+      +V+ LL  MDGL+ R ++ ++ ATNR D IDPA+ RPGR D+     LP  
Sbjct: 516 SRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQ 575

Query: 646 ADRLAILKTITKNGTKPPLDADVNLEAIAGDL--RCDCYTGADLSALVREASICALRQEM 703
             R  IL+  T++   P L      +A  G+L  +C  Y GAD+ AL  EA++ ALR+  
Sbjct: 576 KARKHILQIHTRD-WNPKLS-----DAFLGELAEKCVGYCGADIKALCTEAALIALRRRY 629

Query: 704 ARQKSGNEKGELKVS 718
            +  + + K +L VS
Sbjct: 630 PQIYASSHKLQLDVS 644


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  167 bits (422), Expect = 4e-41
 Identities = 105/274 (38%), Positives = 158/274 (57%), Gaps = 23/274 (8%)

Query: 469 VPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKA 528
           VP+ T+  IG L+   +E+   I  PV++P+ F+ALG+  P GVLL GPPG GKTLLA+A
Sbjct: 143 VPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARA 202

Query: 529 VANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRE 588
           VA+ +   FI V G EL+  ++GE  R VR++F  A+  AP +IF DE+D++   R +  
Sbjct: 203 VAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGG 262

Query: 589 TGAS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPP 645
           +G      R + +LL ++DG EA + + ++ ATNR DI+D A+LRPGR+D+   +  PPP
Sbjct: 263 SGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRK--IEFPPP 320

Query: 646 AD--RLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEM 703
            +  RL ILK    +  K  L   +NL  IA  +     +GA++  +  EA + ALR+  
Sbjct: 321 NEEARLDILKI---HSRKMNLTRGINLRKIAELM--PGASGAEVKGVCTEAGMYALRER- 374

Query: 704 ARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKD 737
                      + V+ + FE A  KV    S+K+
Sbjct: 375 ----------RVHVTQEDFEMAVAKVMQKDSEKN 398



 Score =  164 bits (414), Expect = 4e-40
 Identities = 90/230 (39%), Positives = 137/230 (59%), Gaps = 1/230 (0%)

Query: 152 QISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAH 210
           ++ +  +E +GG D  +KE+ +++ + ++HPE++  LG+  P+GVLL+GPPG GKTLLA 
Sbjct: 142 KVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLAR 201

Query: 211 AIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVA 270
           A+A   D   ++V+  E+V    GE  + +RELF  A  +AP IIF+DEID+I   R   
Sbjct: 202 AVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEG 261

Query: 271 SKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPD 330
               +  +   +L  ++ L+   AT  + VI ATNR D LD AL R GR DR+I    P+
Sbjct: 262 GSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPN 321

Query: 331 EASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAV 380
           E +R  IL+   RK+ L +  +   +A L PG  GA++  +C EA M A+
Sbjct: 322 EEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYAL 371


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  159 bits (403), Expect = 7e-39
 Identities = 108/289 (37%), Positives = 165/289 (57%), Gaps = 24/289 (8%)

Query: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGKTLLAKA 528
           PNV W DI  L + ++ L  A++ P+  P+ FK  G+  P  GVL+ GPPG GKTLLAKA
Sbjct: 204 PNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKA 261

Query: 529 VANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRR-SDR 587
           VA E    F +V    L + Y GESE+ VR +F+ A+  +P  IF DE+D++C RR +  
Sbjct: 262 VATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSE 321

Query: 588 ETGASVRVVNQLLTEMDGL-------EARQQVFIMAATNRPDIIDPAILRPGRLDKTLFV 640
           E  AS RV  +LL +MDG+       +  + V ++AATN P  ID A+ R  RL+K +++
Sbjct: 322 EHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 379

Query: 641 GLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALR 700
            LP    R  +L+   +   +  L  DV+L +IA ++  + Y+GAD++ + R+AS+ A+R
Sbjct: 380 PLPSAKGREELLRISLR---ELELADDVDLASIAENM--EGYSGADITNVCRDASLMAMR 434

Query: 701 QEMAR------QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 743
           + +        +    E+  +  + + FE A KKV  S+S  D   YE+
Sbjct: 435 RRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEK 483



 Score =  138 bits (347), Expect = 2e-32
 Identities = 113/385 (29%), Positives = 191/385 (49%), Gaps = 35/385 (9%)

Query: 45  PRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDS 104
           P    +  S+P+    + S G       P  ++ S + D    KS+  +P T ++  + S
Sbjct: 91  PASEGEVWSMPVPVERRPSPG-------PRKRQSSQYSD---PKSHGNRPSTTVRVHRSS 140

Query: 105 SLLESDMK------RKGKLKNKGSKRKKEDLQEVD----GEIEAVLQKKAKARGLEFQI- 153
           +    + +      R+ K +NKG + K +    V      + ++    K     LE  I 
Sbjct: 141 AQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDII 200

Query: 154 ---SNVKFEDVGGNDMTLKEVCK--MLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLL 208
               NV+++D+  + +  K++ K  +++ M  PE +  +   P +GVL+ GPPG GKTLL
Sbjct: 201 SQNPNVRWDDIA-DLVEAKKLLKEAVVLPMWMPEFFKGIRR-PWKGVLMVGPPGTGKTLL 258

Query: 209 AHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKRE 268
           A A+A E       V++  + S   GESE+ +R LFE A   +P  IFIDEID+I  +R 
Sbjct: 259 AKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRG 318

Query: 269 VASK-DMERRIVAQLLTCMDDL----NNVAATARVLVIGATNRPDSLDPALRRAGRFDRE 323
            + + +  RR+ A+LL  MD +     N   +  V+V+ ATN P  +D ALRR  R ++ 
Sbjct: 319 TSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKR 376

Query: 324 ICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRV 383
           I + +P    RE +L+   R+L L    D   +A    G+ GAD+  +CR+A++ A+ R 
Sbjct: 377 IYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRR 436

Query: 384 LMKLQEQQKKNPEMEDLPSKGVQEE 408
           +  L  ++ +N   E++      E+
Sbjct: 437 IEGLTPEEIRNLSKEEMHMPTTMED 461


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score =  154 bits (389), Expect = 3e-37
 Identities = 91/229 (39%), Positives = 133/229 (58%), Gaps = 4/229 (1%)

Query: 152 QISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHA 211
           Q+ NV FE V G +   +E+ +++  +++P+ +  LG   P+G+LL GPPG GKTLLA A
Sbjct: 332 QMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARA 391

Query: 212 IAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKR-EVA 270
           +AGE D+P    +  E      G    ++R LF +A +NAPC+IFIDE+D++  KR E  
Sbjct: 392 VAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESP 451

Query: 271 SKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPD 330
                R+ + QLL  MD          V++IGATN P++LD AL R GRFD ++ +  PD
Sbjct: 452 MHPYSRQTINQLLAEMDGFK---PNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPD 508

Query: 331 EASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCA 379
              R  IL+    K++  Q+ D   +A  T GF GA+L  L  +AA+ A
Sbjct: 509 VKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKA 557



 Score =  149 bits (375), Expect = 1e-35
 Identities = 92/234 (39%), Positives = 136/234 (58%), Gaps = 9/234 (3%)

Query: 467 VTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLA 526
           V + NVT+  +  +E+ ++EL   ++  ++NP +F  LG   P G+LL GPPG GKTLLA
Sbjct: 331 VQMKNVTFEHVKGVEEAKQEL-QEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLA 389

Query: 527 KAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSD 586
           +AVA E+ + F    G E   M+VG     +R +F+ AK +APCVIF DE+D++  +R +
Sbjct: 390 RAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIE 449

Query: 587 RETGA-SVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPP 645
                 S + +NQLL EMDG +  + V I+ ATN P+ +D A++RPGR D  + V  P  
Sbjct: 450 SPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDV 509

Query: 646 ADRLAILKTITKNGTKPPLDADVNLEAIA-GDLRCDCYTGADLSALVREASICA 698
             R  ILK       K   D  V+ E IA G +    ++GA+L  LV +A++ A
Sbjct: 510 KGRTEILKWYL---NKIKFDQSVDPEIIARGTVG---FSGAELENLVNQAALKA 557


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score =  154 bits (389), Expect = 3e-37
 Identities = 91/229 (39%), Positives = 133/229 (58%), Gaps = 4/229 (1%)

Query: 152 QISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHA 211
           Q+ NV FE V G +   +E+ +++  +++P+ +  LG   P+G+LL GPPG GKTLLA A
Sbjct: 275 QMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARA 334

Query: 212 IAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKR-EVA 270
           +AGE D+P    +  E      G    ++R LF +A +NAPC+IFIDE+D++  KR E  
Sbjct: 335 VAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESP 394

Query: 271 SKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPD 330
                R+ + QLL  MD          V++IGATN P++LD AL R GRFD ++ +  PD
Sbjct: 395 MHPYSRQTINQLLAEMDGFK---PNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPD 451

Query: 331 EASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCA 379
              R  IL+    K++  Q+ D   +A  T GF GA+L  L  +AA+ A
Sbjct: 452 VKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKA 500



 Score =  149 bits (375), Expect = 1e-35
 Identities = 92/234 (39%), Positives = 136/234 (58%), Gaps = 9/234 (3%)

Query: 467 VTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLA 526
           V + NVT+  +  +E+ ++EL   ++  ++NP +F  LG   P G+LL GPPG GKTLLA
Sbjct: 274 VQMKNVTFEHVKGVEEAKQEL-QEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLA 332

Query: 527 KAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSD 586
           +AVA E+ + F    G E   M+VG     +R +F+ AK +APCVIF DE+D++  +R +
Sbjct: 333 RAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIE 392

Query: 587 RETGA-SVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPP 645
                 S + +NQLL EMDG +  + V I+ ATN P+ +D A++RPGR D  + V  P  
Sbjct: 393 SPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDV 452

Query: 646 ADRLAILKTITKNGTKPPLDADVNLEAIA-GDLRCDCYTGADLSALVREASICA 698
             R  ILK       K   D  V+ E IA G +    ++GA+L  LV +A++ A
Sbjct: 453 KGRTEILKWYL---NKIKFDQSVDPEIIARGTVG---FSGAELENLVNQAALKA 500


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  154 bits (388), Expect = 4e-37
 Identities = 96/276 (34%), Positives = 151/276 (54%), Gaps = 10/276 (3%)

Query: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAV 529
           P V W DI  +E  +  +   ++ P+  PD F  L    P G+LL GPPG GKTL+ K +
Sbjct: 396 PPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTGKTLIGKCI 454

Query: 530 ANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589
           A++SG  F S+    L + +VGE E+ VR +F  A+   P VIF DE+D+L  +R D E 
Sbjct: 455 ASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEH 514

Query: 590 GASVRVVNQLLTEMDG--LEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPAD 647
            +S R+  + L ++DG    +  ++ ++ ATNRP  ID A  R  RL K L++ LP  + 
Sbjct: 515 ESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASA 572

Query: 648 RLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQK 707
           R  I+  I     +    ++  +E I    + D ++GAD++ L REAS+  +R       
Sbjct: 573 RKQIV--INLMSKEQCCLSEEEIEQIV--QQSDAFSGADMTQLCREASLGPIRSLQTADI 628

Query: 708 SGNEKGELK-VSHKHFEEAFKKVRSSISKKDQIMYE 742
           +     +++ +++  FE AF+ VR S+S KD  +YE
Sbjct: 629 ATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYE 664



 Score =  121 bits (303), Expect = 3e-27
 Identities = 76/226 (33%), Positives = 124/226 (54%), Gaps = 10/226 (4%)

Query: 156 VKFEDVGGNDM---TLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAI 212
           V +ED+ G +    T+KE+  ++  M  P+++  L   PP+G+LL GPPG GKTL+   I
Sbjct: 398 VNWEDIAGVEFAKATIKEI--VVWPMLRPDIFTGLRG-PPKGILLFGPPGTGKTLIGKCI 454

Query: 213 AGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASK 272
           A +       ++A  + S   GE E+ +R LF  A    P +IFIDEID++  +R     
Sbjct: 455 ASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEH 514

Query: 273 DMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEA 332
           +  RRI  + L  +D     ++  R+LV+GATNRP  +D A RR  R  + + + +P+ +
Sbjct: 515 ESSRRIKTEFLVQLDGA-TTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEAS 571

Query: 333 SRERILQTLCRKLR-LPQAFDFCHLAHLTPGFVGADLMALCREAAM 377
           +R++I+  L  K +      +   +   +  F GAD+  LCREA++
Sbjct: 572 ARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASL 617


>gi|112789543 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  154 bits (388), Expect = 4e-37
 Identities = 96/276 (34%), Positives = 151/276 (54%), Gaps = 10/276 (3%)

Query: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAV 529
           P V W DI  +E  +  +   ++ P+  PD F  L    P G+LL GPPG GKTL+ K +
Sbjct: 396 PPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTGKTLIGKCI 454

Query: 530 ANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589
           A++SG  F S+    L + +VGE E+ VR +F  A+   P VIF DE+D+L  +R D E 
Sbjct: 455 ASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEH 514

Query: 590 GASVRVVNQLLTEMDG--LEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPAD 647
            +S R+  + L ++DG    +  ++ ++ ATNRP  ID A  R  RL K L++ LP  + 
Sbjct: 515 ESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASA 572

Query: 648 RLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQK 707
           R  I+  I     +    ++  +E I    + D ++GAD++ L REAS+  +R       
Sbjct: 573 RKQIV--INLMSKEQCCLSEEEIEQIV--QQSDAFSGADMTQLCREASLGPIRSLQTADI 628

Query: 708 SGNEKGELK-VSHKHFEEAFKKVRSSISKKDQIMYE 742
           +     +++ +++  FE AF+ VR S+S KD  +YE
Sbjct: 629 ATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYE 664



 Score =  121 bits (303), Expect = 3e-27
 Identities = 76/226 (33%), Positives = 124/226 (54%), Gaps = 10/226 (4%)

Query: 156 VKFEDVGGNDM---TLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAI 212
           V +ED+ G +    T+KE+  ++  M  P+++  L   PP+G+LL GPPG GKTL+   I
Sbjct: 398 VNWEDIAGVEFAKATIKEI--VVWPMLRPDIFTGLRG-PPKGILLFGPPGTGKTLIGKCI 454

Query: 213 AGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASK 272
           A +       ++A  + S   GE E+ +R LF  A    P +IFIDEID++  +R     
Sbjct: 455 ASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEH 514

Query: 273 DMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEA 332
           +  RRI  + L  +D     ++  R+LV+GATNRP  +D A RR  R  + + + +P+ +
Sbjct: 515 ESSRRIKTEFLVQLDGA-TTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEAS 571

Query: 333 SRERILQTLCRKLR-LPQAFDFCHLAHLTPGFVGADLMALCREAAM 377
           +R++I+  L  K +      +   +   +  F GAD+  LCREA++
Sbjct: 572 ARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASL 617


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score =  150 bits (380), Expect = 3e-36
 Identities = 103/321 (32%), Positives = 168/321 (52%), Gaps = 23/321 (7%)

Query: 416 SETQDELQRLLGLLRD-----QDPLSEEQMQGLCIELNDFIVALSSVQPSAKR-----EG 465
           +E  D  ++L   L++     Q P+ E Q      + ND      S  P  K+     +G
Sbjct: 63  TEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQG 122

Query: 466 FVTV--PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGK 522
            + +  PNV W+D+  LE  +E L  A++ P++ P  F   G  TP  G+LL GPPG GK
Sbjct: 123 AIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGK 180

Query: 523 TLLAKAVANESGLN-FISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC 581
           + LAKAVA E+  + F S+   +L++ ++GESE+ V+ +FQ A+ + P +IF DE+D+LC
Sbjct: 181 SYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLC 240

Query: 582 PRRSDRETGASVRVVNQLLTEMDGLEA-RQQVFIMAATNRPDIIDPAILRPGRLDKTLFV 640
             RS+ E+ A+ R+  + L +M G+      + ++ ATN P ++D AI R  R +K +++
Sbjct: 241 GSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRR--RFEKRIYI 298

Query: 641 GLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALR 700
            LP P  R A+ K           +AD          + D Y+GAD+S +VR+A +  +R
Sbjct: 299 PLPEPHARAAMFKLHLGTTQNSLTEADFR----ELGRKTDGYSGADISIIVRDALMQPVR 354

Query: 701 QEMARQKSGNEKGELKVSHKH 721
           +  +       +G  +    H
Sbjct: 355 KVQSATHFKKVRGPSRADPNH 375



 Score =  123 bits (308), Expect = 7e-28
 Identities = 105/321 (32%), Positives = 158/321 (49%), Gaps = 30/321 (9%)

Query: 101 SKDSSLLESDMKRKGKLKNKGSKRKK-----------EDLQEVDGEIEAVLQKKAKARG- 148
           +K +  L+   K K  LKNK  K +K           E   + DGE E+   +K K +  
Sbjct: 60  AKCTEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQ 119

Query: 149 ----LEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGV---VPPRGVLLHGPP 201
               +  +  NVK+ DV G +   KE  K  + +  P  + HL      P RG+LL GPP
Sbjct: 120 LQGAIVIERPNVKWSDVAGLEGA-KEALKEAVIL--PIKFPHLFTGKRTPWRGILLFGPP 176

Query: 202 GCGKTLLAHAIAGELD-LPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEI 260
           G GK+ LA A+A E +      +++ ++VS   GESE+ ++ LF+ A  N P IIFIDEI
Sbjct: 177 GTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEI 236

Query: 261 DAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRF 320
           D++   R     +  RRI  + L  M  +        +LV+GATN P  LD A+RR  RF
Sbjct: 237 DSLCGSRSENESEAARRIKTEFLVQMQGVG--VDNDGILVLGATNIPWVLDSAIRR--RF 292

Query: 321 DREICLGIPDEASRERI--LQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMC 378
           ++ I + +P+  +R  +  L     +  L +A DF  L   T G+ GAD+  + R+A M 
Sbjct: 293 EKRIYIPLPEPHARAAMFKLHLGTTQNSLTEA-DFRELGRKTDGYSGADISIIVRDALMQ 351

Query: 379 AVNRVLMKLQEQQKKNPEMED 399
            V +V      ++ + P   D
Sbjct: 352 PVRKVQSATHFKKVRGPSRAD 372


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  149 bits (377), Expect = 7e-36
 Identities = 100/278 (35%), Positives = 152/278 (54%), Gaps = 16/278 (5%)

Query: 472 VTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPA-GVLLAGPPGCGKTLLAKAVA 530
           V + DI   +  ++ L   ++ P   P+ F   GL  PA G+LL GPPG GKT+LAKAVA
Sbjct: 307 VKFDDIAGQDLAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 364

Query: 531 NESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG 590
            ES   F ++    L + YVGE E+ VR +F  A+   P +IF DEVD+L   R + E  
Sbjct: 365 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 424

Query: 591 ASVRVVNQLLTEMDGLEAR--QQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADR 648
           AS R+  + L E DG+++    +V +M ATNRP  +D A+LR  R  K ++V LP    R
Sbjct: 425 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETR 482

Query: 649 LAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ---EMAR 705
           L +LK +      P    ++   A       D Y+G+DL+AL ++A++  +R+   E  +
Sbjct: 483 LLLLKNLLCKQGSPLTQKELAQLA----RMTDGYSGSDLTALAKDAALGPIRELKPEQVK 538

Query: 706 QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 743
             S +E   +++S   F E+ KK++ S+S +    Y R
Sbjct: 539 NMSASEMRNIRLS--DFTESLKKIKRSVSPQTLEAYIR 574



 Score =  142 bits (359), Expect = 9e-34
 Identities = 97/282 (34%), Positives = 154/282 (54%), Gaps = 18/282 (6%)

Query: 124 RKKEDLQE---VDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLI-HMR 179
           RKK+DL+    VD  +  ++  +    G     + VKF+D+ G D+  + + +++I    
Sbjct: 277 RKKKDLKNFRNVDSNLANLIMNEIVDNG-----TAVKFDDIAGQDLAKQALQEIVILPSL 331

Query: 180 HPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQK 239
            PE++  L   P RG+LL GPPG GKT+LA A+A E +     ++A  + S   GE E+ 
Sbjct: 332 RPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 390

Query: 240 LRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVL 299
           +R LF  A    P IIFIDE+D++  +R     D  RR+  + L   D + + A   RVL
Sbjct: 391 VRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQS-AGDDRVL 449

Query: 300 VIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLP-QAFDFCHLAH 358
           V+GATNRP  LD A+ R  RF + + + +P+E +R  +L+ L  K   P    +   LA 
Sbjct: 450 VMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLAR 507

Query: 359 LTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDL 400
           +T G+ G+DL AL ++AA+  +     +L+ +Q KN    ++
Sbjct: 508 MTDGYSGSDLTALAKDAALGPIR----ELKPEQVKNMSASEM 545


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score =  149 bits (377), Expect = 7e-36
 Identities = 100/278 (35%), Positives = 152/278 (54%), Gaps = 16/278 (5%)

Query: 472 VTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPA-GVLLAGPPGCGKTLLAKAVA 530
           V + DI   +  ++ L   ++ P   P+ F   GL  PA G+LL GPPG GKT+LAKAVA
Sbjct: 339 VKFDDIAGQDLAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 396

Query: 531 NESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG 590
            ES   F ++    L + YVGE E+ VR +F  A+   P +IF DEVD+L   R + E  
Sbjct: 397 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 456

Query: 591 ASVRVVNQLLTEMDGLEAR--QQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADR 648
           AS R+  + L E DG+++    +V +M ATNRP  +D A+LR  R  K ++V LP    R
Sbjct: 457 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETR 514

Query: 649 LAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ---EMAR 705
           L +LK +      P    ++   A       D Y+G+DL+AL ++A++  +R+   E  +
Sbjct: 515 LLLLKNLLCKQGSPLTQKELAQLA----RMTDGYSGSDLTALAKDAALGPIRELKPEQVK 570

Query: 706 QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 743
             S +E   +++S   F E+ KK++ S+S +    Y R
Sbjct: 571 NMSASEMRNIRLS--DFTESLKKIKRSVSPQTLEAYIR 606



 Score =  142 bits (359), Expect = 9e-34
 Identities = 97/282 (34%), Positives = 154/282 (54%), Gaps = 18/282 (6%)

Query: 124 RKKEDLQE---VDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLI-HMR 179
           RKK+DL+    VD  +  ++  +    G     + VKF+D+ G D+  + + +++I    
Sbjct: 309 RKKKDLKNFRNVDSNLANLIMNEIVDNG-----TAVKFDDIAGQDLAKQALQEIVILPSL 363

Query: 180 HPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQK 239
            PE++  L   P RG+LL GPPG GKT+LA A+A E +     ++A  + S   GE E+ 
Sbjct: 364 RPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 422

Query: 240 LRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVL 299
           +R LF  A    P IIFIDE+D++  +R     D  RR+  + L   D + + A   RVL
Sbjct: 423 VRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQS-AGDDRVL 481

Query: 300 VIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLP-QAFDFCHLAH 358
           V+GATNRP  LD A+ R  RF + + + +P+E +R  +L+ L  K   P    +   LA 
Sbjct: 482 VMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLAR 539

Query: 359 LTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDL 400
           +T G+ G+DL AL ++AA+  +     +L+ +Q KN    ++
Sbjct: 540 MTDGYSGSDLTALAKDAALGPIR----ELKPEQVKNMSASEM 577


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  147 bits (372), Expect = 3e-35
 Identities = 91/267 (34%), Positives = 150/267 (56%), Gaps = 12/267 (4%)

Query: 471 NVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPA-GVLLAGPPGCGKTLLAKAV 529
           +VTW+DI  L+D+  +L   ++ P++    F+   L+ P  GVLL GPPGCGKTL+AKA 
Sbjct: 87  HVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKAT 146

Query: 530 ANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589
           A E+G  FI+++   L + + GES++    VF  A    P +IF DE+D+    RS  + 
Sbjct: 147 AKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDH 206

Query: 590 GASVRVVNQLLTEMDGLEARQ--QVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPAD 647
            A+  +  Q ++  DGL+     QV +M ATNRP  +D AI+R  R+     +  P    
Sbjct: 207 EATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMR--RMPTRFHINQPALKQ 264

Query: 648 RLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEM-ARQ 706
           R AILK I KN     +D  V+L  +A +   D ++G+DL  + R+A++  +R+ + +  
Sbjct: 265 REAILKLILKNEN---VDRHVDLLEVAQE--TDGFSGSDLKEMCRDAALLCVREYVNSTS 319

Query: 707 KSGNEKGELK-VSHKHFEEAFKKVRSS 732
           +  +++ E++ V  +    A +K++ S
Sbjct: 320 EESHDEDEIRPVQQQDLHRAIEKMKKS 346



 Score =  124 bits (312), Expect = 2e-28
 Identities = 87/287 (30%), Positives = 138/287 (48%), Gaps = 16/287 (5%)

Query: 123 KRKKEDLQEVDGEIEAVLQKKAKARGLEFQIS---------NVKFEDVGGND---MTLKE 170
           K+K E  ++ +  ++ +  K  K    E  I+         +V + D+ G D     LK+
Sbjct: 46  KQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITDLKD 105

Query: 171 VCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVS 230
              + I  +H      L + PP+GVLL+GPPGCGKTL+A A A E     + +    +  
Sbjct: 106 TVILPIKKKHLFENSRL-LQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTD 164

Query: 231 GVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLN 290
              GES++    +F  A+   P IIFIDEID+    R  +  +    + AQ ++  D L 
Sbjct: 165 KWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGL- 223

Query: 291 NVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQA 350
           +   + +V+V+GATNRP  LD A+ R  R      +  P    RE IL+ + +   + + 
Sbjct: 224 DTDHSCQVIVMGATNRPQDLDSAIMR--RMPTRFHINQPALKQREAILKLILKNENVDRH 281

Query: 351 FDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEM 397
            D   +A  T GF G+DL  +CR+AA+  V   +    E+     E+
Sbjct: 282 VDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDEDEI 328


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,489,566
Number of Sequences: 37866
Number of extensions: 1408132
Number of successful extensions: 6024
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 5559
Number of HSP's gapped (non-prelim): 339
length of query: 750
length of database: 18,247,518
effective HSP length: 110
effective length of query: 640
effective length of database: 14,082,258
effective search space: 9012645120
effective search space used: 9012645120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.