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Search of human proteins with 4505725
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505725 peroxin1 [Homo sapiens]
(1283 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505725 peroxin1 [Homo sapiens] 2537 0.0
gi|6005942 valosin-containing protein [Homo sapiens] 273 6e-73
gi|157671927 spermatogenesis associated 5 [Homo sapiens] 268 2e-71
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens] 258 3e-68
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens] 239 1e-62
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens] 233 9e-61
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens] 233 9e-61
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens] 179 1e-44
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens] 177 4e-44
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens] 169 2e-41
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens] 165 3e-40
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens] 159 1e-38
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ... 157 5e-38
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi... 157 5e-38
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens] 157 5e-38
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens] 152 2e-36
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens] 152 2e-36
gi|156564401 vesicle-fusing ATPase [Homo sapiens] 149 2e-35
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens] 148 3e-35
gi|113426932 PREDICTED: similar to N-ethylmaleimide-sensitive fa... 147 5e-35
gi|5901990 katanin p60 subunit A 1 [Homo sapiens] 147 6e-35
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens] 142 2e-33
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens] 142 2e-33
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens] 140 6e-33
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens] 140 6e-33
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens] 137 7e-32
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens] 134 6e-31
gi|40806170 spastin isoform 2 [Homo sapiens] 132 2e-30
gi|11875211 spastin isoform 1 [Homo sapiens] 132 2e-30
gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens] 131 4e-30
>gi|4505725 peroxin1 [Homo sapiens]
Length = 1283
Score = 2537 bits (6576), Expect = 0.0
Identities = 1283/1283 (100%), Positives = 1283/1283 (100%)
Query: 1 MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVVWSHQPAFLSW 60
MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVVWSHQPAFLSW
Sbjct: 1 MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVVWSHQPAFLSW 60
Query: 61 VEGRHFSDQGENVAEINRQVGQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILE 120
VEGRHFSDQGENVAEINRQVGQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILE
Sbjct: 61 VEGRHFSDQGENVAEINRQVGQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILE 120
Query: 121 LHAVSLEQHLLDQIRIVFPKAIFPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPK 180
LHAVSLEQHLLDQIRIVFPKAIFPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPK
Sbjct: 121 LHAVSLEQHLLDQIRIVFPKAIFPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPK 180
Query: 181 TRRAKENTFSKADAEYKKLHSYGRDQKGMMKELQTKQLQSNTVGITESNENESEIPVDSS 240
TRRAKENTFSKADAEYKKLHSYGRDQKGMMKELQTKQLQSNTVGITESNENESEIPVDSS
Sbjct: 181 TRRAKENTFSKADAEYKKLHSYGRDQKGMMKELQTKQLQSNTVGITESNENESEIPVDSS 240
Query: 241 SVASLWTMIGSIFSFQSEKKQETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNA 300
SVASLWTMIGSIFSFQSEKKQETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNA
Sbjct: 241 SVASLWTMIGSIFSFQSEKKQETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNA 300
Query: 301 SATSVFHKHCAIHVFPWDQEYFDVEPSFTVTYGKLVKLLSPKQQQSKTKQNVLSPEKEKQ 360
SATSVFHKHCAIHVFPWDQEYFDVEPSFTVTYGKLVKLLSPKQQQSKTKQNVLSPEKEKQ
Sbjct: 301 SATSVFHKHCAIHVFPWDQEYFDVEPSFTVTYGKLVKLLSPKQQQSKTKQNVLSPEKEKQ 360
Query: 361 MSEPLDQKKIRSDHNEEDEKACVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIPDDLRK 420
MSEPLDQKKIRSDHNEEDEKACVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIPDDLRK
Sbjct: 361 MSEPLDQKKIRSDHNEEDEKACVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIPDDLRK 420
Query: 421 RLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPL 480
RLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPL
Sbjct: 421 RLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPL 480
Query: 481 VISEEEFIKLETKDGLKEFSLSIVHSWEKEKDKNIFLLSPNLLQKTTIQVLLDPMVKEEN 540
VISEEEFIKLETKDGLKEFSLSIVHSWEKEKDKNIFLLSPNLLQKTTIQVLLDPMVKEEN
Sbjct: 481 VISEEEFIKLETKDGLKEFSLSIVHSWEKEKDKNIFLLSPNLLQKTTIQVLLDPMVKEEN 540
Query: 541 SEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSRQLMSLVAGLRNGALLLTGG 600
SEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSRQLMSLVAGLRNGALLLTGG
Sbjct: 541 SEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSRQLMSLVAGLRNGALLLTGG 600
Query: 601 KGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVL 660
KGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVL
Sbjct: 601 KGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVL 660
Query: 661 LDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHP 720
LDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHP
Sbjct: 661 LDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHP 720
Query: 721 LLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFV 780
LLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFV
Sbjct: 721 LLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFV 780
Query: 781 ARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWD 840
ARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWD
Sbjct: 781 ARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWD 840
Query: 841 KIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRM 900
KIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRM
Sbjct: 841 KIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRM 900
Query: 901 NFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRV 960
NFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRV
Sbjct: 901 NFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRV 960
Query: 961 VNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVL 1020
VNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVL
Sbjct: 961 VNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVL 1020
Query: 1021 SDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLS 1080
SDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLS
Sbjct: 1021 SDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLS 1080
Query: 1081 LSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGN 1140
LSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGN
Sbjct: 1081 LSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGN 1140
Query: 1141 GTSSDLSSQCLSAPSSMTQDLPGVPGKDQLFSQPPVLRTASQEGCQELTQEQRDQLRADI 1200
GTSSDLSSQCLSAPSSMTQDLPGVPGKDQLFSQPPVLRTASQEGCQELTQEQRDQLRADI
Sbjct: 1141 GTSSDLSSQCLSAPSSMTQDLPGVPGKDQLFSQPPVLRTASQEGCQELTQEQRDQLRADI 1200
Query: 1201 SIIKGRYRSQSGEDESMNQPGPIKTRLAISQSHLMTALGHTRPSISEDDWKNFAELYESF 1260
SIIKGRYRSQSGEDESMNQPGPIKTRLAISQSHLMTALGHTRPSISEDDWKNFAELYESF
Sbjct: 1201 SIIKGRYRSQSGEDESMNQPGPIKTRLAISQSHLMTALGHTRPSISEDDWKNFAELYESF 1260
Query: 1261 QNPKRRKNQSGTMFRPGQKVTLA 1283
QNPKRRKNQSGTMFRPGQKVTLA
Sbjct: 1261 QNPKRRKNQSGTMFRPGQKVTLA 1283
>gi|6005942 valosin-containing protein [Homo sapiens]
Length = 806
Score = 273 bits (699), Expect = 6e-73
Identities = 172/474 (36%), Positives = 257/474 (54%), Gaps = 34/474 (7%)
Query: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWM 654
+LL G G+GK+ +A+A+ E A ++ + K + L AF EA
Sbjct: 241 ILLYGPPGTGKTLIARAVANET----GAFFFLINGPEIMSKLAGESESNLRKAFEEAEKN 296
Query: 655 QPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQS 714
P+++ +D+LD IA P+ E + V+ + ++ L M + + + V ++A +
Sbjct: 297 APAIIFIDELDAIA-----PKREKTHGEVERRIVSQLLTLM--DGLKQRAHVIVMAATNR 349
Query: 715 QQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAK 774
S+ P L + F I P+ R EIL KN D D+DL+ VA
Sbjct: 350 PNSIDPAL---RRFGRFDREVDIGIPDATGRLEILQIHTKNMKLAD-----DVDLEQVAN 401
Query: 775 ETGGFVARDFTVLVDRAIHSRLSRQ-----------SISTREKLVLTTLDFQKALRGFLP 823
ET G V D L A + ++ L +T DF+ AL P
Sbjct: 402 ETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNP 461
Query: 824 ASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPP 883
++LR + P+ + W+ IGGL +V++ L + +Q P ++P+ F + G+L YGPP
Sbjct: 462 SALRETVVEVPQ-VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPP 520
Query: 884 GTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFE 943
G GKTLLA IA E + NFIS+KGPELL+ + G SE VR+IF +A+ A PC+LFFDE +
Sbjct: 521 GCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELD 580
Query: 944 SIAPRRG---HDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLD 1000
SIA RG D G DRV+NQ+LT++DG+ + V+++ AT+RPD+IDPA+LRPGRLD
Sbjct: 581 SIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLD 640
Query: 1001 KCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNA 1054
+ +Y P PD+ SR+ IL P+A DVDL+ +A +T+ F+GADL + A
Sbjct: 641 QLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRA 694
Score = 190 bits (482), Expect = 9e-48
Identities = 104/247 (42%), Positives = 153/247 (61%)
Query: 836 DLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIA 895
++G+D IGG + + + ++LP ++P LF + ++ GILLYGPPGTGKTL+A +A
Sbjct: 200 EVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVA 259
Query: 896 RESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTG 955
E+ F + GPE++SK G SE +R F A+ P I+F DE ++IAP+R +
Sbjct: 260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGE 319
Query: 956 VTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLE 1015
V R+V+QLLT +DG++ V V+AAT+RP+ IDPAL R GR D+ V PD RLE
Sbjct: 320 VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLE 379
Query: 1016 ILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSS 1075
IL + + ++ LADDVDL+ VA+ T GADL AL A L+A+ + L+D + +
Sbjct: 380 ILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDA 439
Query: 1076 DSDLSLS 1082
+ SL+
Sbjct: 440 EVMNSLA 446
>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
Length = 893
Score = 268 bits (686), Expect = 2e-71
Identities = 163/477 (34%), Positives = 268/477 (56%), Gaps = 30/477 (6%)
Query: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWM 654
+LL G G+GK+ +A+A+ E + A+V ++ + K + L F+EA
Sbjct: 390 VLLYGPPGTGKTMIARAVANE----VGAYVSVINGPEIISKFYGETEAKLRQIFAEATLR 445
Query: 655 QPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALN--DMIKEFISMGSLVALIATS 712
PS++ +D+LD + P+ E + + V+ + +A L D I +S G ++ L AT+
Sbjct: 446 HPSIIFIDELDALC-----PKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATN 500
Query: 713 QSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHV 772
+ H L + + F I PN + R +IL +++ + T+ +L +
Sbjct: 501 RP----HALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVP----HLLTEAELLQL 552
Query: 773 AKETGGFVARDFTVLVDRAIHSRLSR--------QSISTREKLVLTTLDFQKALRGFLPA 824
A G+V D VL + A L R + + +T DF +A+ P+
Sbjct: 553 ANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPS 612
Query: 825 SLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPG 884
++R + + P ++ W IGGL ++ L ++ P K+PE F + I+ G+LLYGPPG
Sbjct: 613 AMREIAIDVP-NVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPG 671
Query: 885 TGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFES 944
KT++A +A ES +NF+++KGPEL++KY+G SE+AVR+ F +A+A P I+FFDE ++
Sbjct: 672 CSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDA 731
Query: 945 IAPRRGHD--NTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKC 1002
+A RG V DRV+ QLLT++DG+E L+ V +LAAT+RPD ID AL+RPGR+D+
Sbjct: 732 LAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRI 791
Query: 1003 VYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
+Y P PD +R EI + S+P++++VDL + TD+++GA++ A+ A L AL
Sbjct: 792 IYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLAL 848
Score = 159 bits (402), Expect = 2e-38
Identities = 95/229 (41%), Positives = 131/229 (57%), Gaps = 4/229 (1%)
Query: 839 WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898
+D IGGL + + + I+LP K PELF + I G+LLYGPPGTGKT++A +A E
Sbjct: 352 YDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEV 411
Query: 899 RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTD 958
+ GPE++SK+ G +E +R IF A P I+F DE +++ P+R V
Sbjct: 412 GAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEK 471
Query: 959 RVVNQLLTQLDGV--EGLQG-VYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLE 1015
RVV LLT +DG+ E +G V VL AT+RP +D AL RPGR DK + P+ RL+
Sbjct: 472 RVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLD 531
Query: 1016 ILNVLSDSLP-LADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGML 1063
IL L +P L + +L +A+ + GADLK L A L AL +L
Sbjct: 532 ILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRIL 580
>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
Length = 980
Score = 258 bits (658), Expect = 3e-68
Identities = 190/537 (35%), Positives = 287/537 (53%), Gaps = 46/537 (8%)
Query: 560 NSLGVSSLEHITHSLLG--RPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAF 617
+SL LE + L +P + +L+ G ++LL G G GK+T+ A C
Sbjct: 431 SSLSPPGLEALVSELCAVLKPRLQPGGALLTG--TSSVLLRGPPGCGKTTVVAAACSH-- 486
Query: 618 DKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHE 677
L H+ +V C +L + ++ L+ FS A +P+V+LL +DL+
Sbjct: 487 --LGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGR----DRDG 540
Query: 678 HSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHI 737
DA L H L + ++ ++ + ++AT+ Q L P V H + +
Sbjct: 541 LGEDARVMAVLRHLL--LNEDPLNSCPPLMVVATTSRAQDL-PADVQTAFPHELE----V 593
Query: 738 QPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFVARDFTVLV---DRAIHS 794
++ QR IL L + +++L +A+ GFV D L+ RA +
Sbjct: 594 PALSEGQRLSIL-----RALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACT 648
Query: 795 RLSRQSIS---TREK--------LVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIG 843
R+ ++ T E L DF +AL A ++V K + W +G
Sbjct: 649 RIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSVSWHDVG 708
Query: 844 GLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFI 903
GL EV++ +++TIQLP ++PEL + L +R R+G+LL+GPPGTGKTLLA +A E + F+
Sbjct: 709 GLQEVKKEILETIQLPLEHPELLS-LGLR-RSGLLLHGPPGTGKTLLAKAVATECSLTFL 766
Query: 904 SVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGH--DNTGVTDRVV 961
SVKGPEL++ Y+G SE+ VR++F RA+AA PCI+FFDE +S+AP RG D+ GV DRVV
Sbjct: 767 SVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVV 826
Query: 962 NQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYC-PPPDQVSRLEILNVL 1020
+QLL +LDG+ Q V+V+ AT+RPDL+DPALLRPGR DK V+ D+ S+L +L+ +
Sbjct: 827 SQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAI 886
Query: 1021 SDSLPLADDVDLQHVAS-VTDSFTGADLKALLYNAQLEALHGML--LSSGLQDGSSS 1074
+ L V L +V TGADL +L +A AL + L GL+ GSS+
Sbjct: 887 TRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSA 943
>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
Length = 753
Score = 239 bits (610), Expect = 1e-62
Identities = 185/527 (35%), Positives = 277/527 (52%), Gaps = 56/527 (10%)
Query: 563 GVSSLEHITHSLLGRPLS--RQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKL 620
G+S LL PL R L +L + G +LL G G GK+ L +A+ +EA +L
Sbjct: 204 GLSEAADSLRELLRLPLRYPRALTALGLAVPRG-VLLAGPPGVGKTQLVRAVAREAGAEL 262
Query: 621 DAHVERVDCKALRGKRL----ENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEH 676
A V AL+G R EN+++ + A E PS++ LD++D +
Sbjct: 263 LA----VSAPALQGSRPGETEENVRRVFQRA-RELASRGPSLLFLDEMDALCP------- 310
Query: 677 EHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQH 736
+ A +S+ +A L + + S V ++ + +L P L + F
Sbjct: 311 QRGSRAPESRVVAQVLT--LLDGASGDREVVVVGATNRPDALDPAL---RRPGRFDREVV 365
Query: 737 IQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFVARDFTVLV-DRAIHSR 795
I P +QR EIL VI +K+ I+ DL L +A+ T G+V D T L + A+H+
Sbjct: 366 IGTPTLKQRKEIL-QVITSKMP--ISSHVDLGL--LAEMTVGYVGADLTALCREAAMHAL 420
Query: 796 LSRQSISTREKLVLTTLDFQKALRGFLPASLRSV-NLHKPRDLGWDKIGGLHEVRQILMD 854
L S ++ V+ +DF +A + P+S RSV L + + W++IGGL +V+ L
Sbjct: 421 L--HSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQ 478
Query: 855 TIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKY 914
+I+ P K+P F + + Q G+LLYGPPG KT L +A +F+SV G +L S +
Sbjct: 479 SIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPF 538
Query: 915 IGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTG--VTDRVVNQLLTQLDGVE 972
+G SE+ + IF +A+A+ P ILF DE +SI R TG V +RV++ LL +LDGV
Sbjct: 539 VGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGV- 597
Query: 973 GL--------------------QGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVS 1012
GL + V ++AAT+RPD++D ALLRPGRLDK +Y PPPD
Sbjct: 598 GLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKG 657
Query: 1013 RLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
RL IL V + ++P+ DV L+++A+ T F+GADL+ L A L AL
Sbjct: 658 RLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLAL 704
Score = 160 bits (405), Expect = 7e-39
Identities = 95/240 (39%), Positives = 134/240 (55%), Gaps = 8/240 (3%)
Query: 842 IGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMN 901
+GGL E L + ++LP +YP L + G+LL GPPG GKT L +ARE+
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
Query: 902 FISVKGPELLSKYIGASEQAVRDIFIRAQ---AAKPCILFFDEFESIAPRRGHDNTGVTD 958
++V P L G +E+ VR +F RA+ + P +LF DE +++ P+RG +
Sbjct: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRG--SRAPES 319
Query: 959 RVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILN 1018
RVV Q+LT LDG G + V V+ AT+RPD +DPAL RPGR D+ V P R EIL
Sbjct: 320 RVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQ 379
Query: 1019 VLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSD 1078
V++ +P++ VDL +A +T + GADL AL A A+H +L S QD + D
Sbjct: 380 VITSKMPISSHVDLGLLAEMTVGYVGADLTALCREA---AMHALLHSEKNQDNPVIDEID 436
>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
Length = 750
Score = 233 bits (594), Expect = 9e-61
Identities = 173/524 (33%), Positives = 260/524 (49%), Gaps = 78/524 (14%)
Query: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDC-KALRGKRLENIQKTLEVAFSEAVW 653
+LL G G GK+ LA AI E LD + +V + + G E+ QK E+ F +AV
Sbjct: 195 VLLHGPPGCGKTLLAHAIAGE----LDLPILKVAAPEIVSGVSGESEQKLREL-FEQAVS 249
Query: 654 MQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIK-EFISMGSLVALIATS 712
P ++ +D++D I P+ E + ++ + +A L M ++ + V +I +
Sbjct: 250 NAPCIIFIDEIDAIT-----PKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGAT 304
Query: 713 QSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHV 772
SL P L A C+ ++E+ + LC ++ D H+
Sbjct: 305 NRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLP--------QAFDFCHL 356
Query: 773 AKETGGFVARDFTVLVDRAIHSRLSRQSISTREK-------------------------- 806
A T GFV D L A ++R + +E+
Sbjct: 357 AHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTS 416
Query: 807 --------------------------LVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWD 840
L + DF AL P++ R + P ++ W
Sbjct: 417 ETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVP-NVTWA 475
Query: 841 KIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRM 900
IG L ++R+ L I P + P+ F L + G+LL GPPG GKTLLA +A ES +
Sbjct: 476 DIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGL 535
Query: 901 NFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRV 960
NFISVKGPELL+ Y+G SE+AVR +F RA+ + PC++FFDE +++ PRR TG + RV
Sbjct: 536 NFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRV 595
Query: 961 VNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYC---PPPDQVSRLEIL 1017
VNQLLT++DG+E Q V+++AAT+RPD+IDPA+LRPGRLDK ++ PP D+++ L+ +
Sbjct: 596 VNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTI 655
Query: 1018 NVLSDSLPLADDVDLQHVAS--VTDSFTGADLKALLYNAQLEAL 1059
PL DV+L+ +A D +TGADL AL+ A + AL
Sbjct: 656 TKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICAL 699
Score = 151 bits (381), Expect = 4e-36
Identities = 87/222 (39%), Positives = 128/222 (57%), Gaps = 3/222 (1%)
Query: 861 KYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQ 920
++PE++ +L + G+LL+GPPG GKTLLA IA E + + V PE++S G SEQ
Sbjct: 179 RHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQ 238
Query: 921 AVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQG---V 977
+R++F +A + PCI+F DE ++I P+R + + R+V QLLT +D + + V
Sbjct: 239 KLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARV 298
Query: 978 YVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVAS 1037
V+ AT+RPD +DPAL R GR D+ + PD+ SR IL L L L D H+A
Sbjct: 299 LVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAH 358
Query: 1038 VTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDL 1079
+T F GADL AL A + A++ +L+ Q + DL
Sbjct: 359 LTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDL 400
>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
Length = 856
Score = 233 bits (594), Expect = 9e-61
Identities = 173/524 (33%), Positives = 260/524 (49%), Gaps = 78/524 (14%)
Query: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDC-KALRGKRLENIQKTLEVAFSEAVW 653
+LL G G GK+ LA AI E LD + +V + + G E+ QK E+ F +AV
Sbjct: 301 VLLHGPPGCGKTLLAHAIAGE----LDLPILKVAAPEIVSGVSGESEQKLREL-FEQAVS 355
Query: 654 MQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIK-EFISMGSLVALIATS 712
P ++ +D++D I P+ E + ++ + +A L M ++ + V +I +
Sbjct: 356 NAPCIIFIDEIDAIT-----PKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGAT 410
Query: 713 QSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHV 772
SL P L A C+ ++E+ + LC ++ D H+
Sbjct: 411 NRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLP--------QAFDFCHL 462
Query: 773 AKETGGFVARDFTVLVDRAIHSRLSRQSISTREK-------------------------- 806
A T GFV D L A ++R + +E+
Sbjct: 463 AHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTS 522
Query: 807 --------------------------LVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWD 840
L + DF AL P++ R + P ++ W
Sbjct: 523 ETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVP-NVTWA 581
Query: 841 KIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRM 900
IG L ++R+ L I P + P+ F L + G+LL GPPG GKTLLA +A ES +
Sbjct: 582 DIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGL 641
Query: 901 NFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRV 960
NFISVKGPELL+ Y+G SE+AVR +F RA+ + PC++FFDE +++ PRR TG + RV
Sbjct: 642 NFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRV 701
Query: 961 VNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYC---PPPDQVSRLEIL 1017
VNQLLT++DG+E Q V+++AAT+RPD+IDPA+LRPGRLDK ++ PP D+++ L+ +
Sbjct: 702 VNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTI 761
Query: 1018 NVLSDSLPLADDVDLQHVAS--VTDSFTGADLKALLYNAQLEAL 1059
PL DV+L+ +A D +TGADL AL+ A + AL
Sbjct: 762 TKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICAL 805
Score = 151 bits (381), Expect = 4e-36
Identities = 87/222 (39%), Positives = 128/222 (57%), Gaps = 3/222 (1%)
Query: 861 KYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQ 920
++PE++ +L + G+LL+GPPG GKTLLA IA E + + V PE++S G SEQ
Sbjct: 285 RHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQ 344
Query: 921 AVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQG---V 977
+R++F +A + PCI+F DE ++I P+R + + R+V QLLT +D + + V
Sbjct: 345 KLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARV 404
Query: 978 YVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVAS 1037
V+ AT+RPD +DPAL R GR D+ + PD+ SR IL L L L D H+A
Sbjct: 405 LVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAH 464
Query: 1038 VTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDL 1079
+T F GADL AL A + A++ +L+ Q + DL
Sbjct: 465 LTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDL 506
>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
Length = 403
Score = 179 bits (455), Expect = 1e-44
Identities = 98/266 (36%), Positives = 157/266 (59%), Gaps = 3/266 (1%)
Query: 797 SRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTI 856
S+ TR L +TTL + L + + +++ P ++ + +IGGL E + L + I
Sbjct: 104 SKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVI 163
Query: 857 QLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIG 916
+LP PELF + I G LLYGPPGTGKTLLA +A + NF+ V ++ KYIG
Sbjct: 164 ELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIG 223
Query: 917 ASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGV---TDRVVNQLLTQLDGVEG 973
S + +R++F A+ +PCI+F DE ++I RR + T R + +LL Q+DG +
Sbjct: 224 ESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDT 283
Query: 974 LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQ 1033
L V ++ AT+RPD +DPALLRPGRLD+ ++ P++ +RL+IL + + + ++D +
Sbjct: 284 LHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYE 343
Query: 1034 HVASVTDSFTGADLKALLYNAQLEAL 1059
+ ++D F GADL+ + A + A+
Sbjct: 344 AIVKLSDGFNGADLRNVCTEAGMFAI 369
Score = 50.1 bits (118), Expect = 1e-05
Identities = 67/306 (21%), Positives = 126/306 (41%), Gaps = 42/306 (13%)
Query: 523 LQKTTIQVL------LDPMVKEENSEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSLLG 576
L TT+ ++ +DP+V + E+ + S +GG++ + L + L
Sbjct: 114 LDMTTLTIMRYLPREVDPLVYNMSHEDPGNV----SYSEIGGLSEQ-IRELREVIELPLT 168
Query: 577 RPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKR 636
P +L V + LL G G+GK+ LA+A+ + LD + +V ++ K
Sbjct: 169 NP---ELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQ----LDCNFLKVVSSSIVDKY 221
Query: 637 LENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMI 696
+ + + F+ A QP ++ +D++D I G S + + L +++
Sbjct: 222 IGESARLIREMFNYARDHQPCIIFMDEIDAIGG------RRFSEGTSADREIQRTLMELL 275
Query: 697 KEFISMGSL--VALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIK 754
+ +L V +I + +L P L+ + HI PN++ R +IL
Sbjct: 276 NQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRL---DRKIHIDLPNEQARLDIL----- 327
Query: 755 NKLDC-DINKFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLD 813
K+ I K ++D + + K + GF D R + + +I V+ D
Sbjct: 328 -KIHAGPITKHGEIDYEAIVKLSDGFNGADL-----RNVCTEAGMFAIRADHDFVVQE-D 380
Query: 814 FQKALR 819
F KA+R
Sbjct: 381 FMKAVR 386
>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
Length = 406
Score = 177 bits (450), Expect = 4e-44
Identities = 94/232 (40%), Positives = 142/232 (61%), Gaps = 3/232 (1%)
Query: 831 LHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLL 890
+ K D ++ IGGL + + + + I+LP K+PELF L I Q G+LLYGPPGTGKTLL
Sbjct: 140 VEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLL 199
Query: 891 AGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRR- 949
A +A + FI V G EL+ K+IG + VR++F+ A+ P I+F DE +SI R
Sbjct: 200 ARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRL 259
Query: 950 --GHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPP 1007
G R + +LL QLDG E + + V+ AT+R D++D ALLRPGR+D+ + PP
Sbjct: 260 EGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPP 319
Query: 1008 PDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
P++ +RL+IL + S + L ++L+ +A + +GA++K + A + AL
Sbjct: 320 PNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYAL 371
>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
Length = 440
Score = 169 bits (427), Expect = 2e-41
Identities = 90/241 (37%), Positives = 141/241 (58%), Gaps = 3/241 (1%)
Query: 842 IGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMN 901
IGGL Q + ++++LP +PE + + I+ G++LYGPPGTGKTLLA +A ++
Sbjct: 187 IGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSAT 246
Query: 902 FISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTG---VTD 958
F+ V G EL+ KY+G + VR++F A+ P I+F DE ++I +R N+G
Sbjct: 247 FLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQ 306
Query: 959 RVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILN 1018
R + +LL QLDG + V V+ AT+R + +DPAL+RPGR+D+ + P PD+ ++ I
Sbjct: 307 RTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQ 366
Query: 1019 VLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSD 1078
+ + + LADDV L + D +GAD+KA+ A L AL + +D S ++
Sbjct: 367 IHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENV 426
Query: 1079 L 1079
L
Sbjct: 427 L 427
Score = 37.4 bits (85), Expect = 0.093
Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 8/129 (6%)
Query: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWM 654
++L G G+GK+ LAKA+ + A RV L K L + K + F A
Sbjct: 222 VILYGPPGTGKTLLAKAVANQT----SATFLRVVGSELIQKYLGDGPKLVRELFRVAEEH 277
Query: 655 QPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQS 714
PS+V +D++D I +S + QR L + + F S G + ++AT++
Sbjct: 278 APSIVFIDEIDAIG---TKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRI 334
Query: 715 QQSLHPLLV 723
++L P L+
Sbjct: 335 -ETLDPALI 342
>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
Length = 439
Score = 165 bits (417), Expect = 3e-40
Identities = 92/225 (40%), Positives = 136/225 (60%), Gaps = 5/225 (2%)
Query: 839 WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898
+ IGGL + Q L++ I LP + E F NL I+ G+L+YGPPGTGKTLLA A ++
Sbjct: 185 YSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQT 244
Query: 899 RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTD 958
+ F+ + GP+L+ +IG + VRD F A+ P I+F DE ++I +R D+ D
Sbjct: 245 KATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKR-FDSEKAGD 303
Query: 959 RVVN----QLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRL 1014
R V +LL QLDG + V V+AAT+R D++DPALLR GRLD+ + P P++ +R
Sbjct: 304 REVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARA 363
Query: 1015 EILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
I+ + S + ++ DV+ + +A TD F GA KA+ A + AL
Sbjct: 364 RIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIAL 408
>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
Length = 433
Score = 159 bits (403), Expect = 1e-38
Identities = 84/227 (37%), Positives = 132/227 (58%), Gaps = 3/227 (1%)
Query: 836 DLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIA 895
D+ + +GG E + L + ++ P +PE F NL I G+LL+GPPGTGKTL A +A
Sbjct: 171 DVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVA 230
Query: 896 RESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTG 955
+ FI V G EL+ KY+G + VR++F A+ K C++FFDE ++I R D G
Sbjct: 231 NRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAG 290
Query: 956 ---VTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVS 1012
R + +L+ QLDG + + VL AT+RPD +DPAL+RPGRLD+ + PD
Sbjct: 291 GDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEG 350
Query: 1013 RLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
R I + + S+ + D+ + +A + + TGA+++++ A + A+
Sbjct: 351 RTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAI 397
>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
[Homo sapiens]
Length = 414
Score = 157 bits (398), Expect = 5e-38
Identities = 83/239 (34%), Positives = 140/239 (58%), Gaps = 3/239 (1%)
Query: 824 ASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPP 883
+S+ + + D+ + IGG+ +Q + + ++LP + EL+ + I G+L+YGPP
Sbjct: 145 SSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPP 204
Query: 884 GTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFE 943
G GKT+LA +A + FI V G E + KY+G + VRD+F A+ P I+F DE +
Sbjct: 205 GCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEID 264
Query: 944 SIAPRRGHDNTGV---TDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLD 1000
+IA +R TG R++ +LL Q+DG + V V+ AT+R D +DPALLRPGRLD
Sbjct: 265 AIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLD 324
Query: 1001 KCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
+ + P PD+ + I + ++ + L+++VDL+ + D +GAD+ ++ + + A+
Sbjct: 325 RKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAV 383
>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapiens]
Length = 387
Score = 157 bits (398), Expect = 5e-38
Identities = 83/239 (34%), Positives = 140/239 (58%), Gaps = 3/239 (1%)
Query: 824 ASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPP 883
+S+ + + D+ + IGG+ +Q + + ++LP + EL+ + I G+L+YGPP
Sbjct: 118 SSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPP 177
Query: 884 GTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFE 943
G GKT+LA +A + FI V G E + KY+G + VRD+F A+ P I+F DE +
Sbjct: 178 GCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEID 237
Query: 944 SIAPRRGHDNTGV---TDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLD 1000
+IA +R TG R++ +LL Q+DG + V V+ AT+R D +DPALLRPGRLD
Sbjct: 238 AIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLD 297
Query: 1001 KCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
+ + P PD+ + I + ++ + L+++VDL+ + D +GAD+ ++ + + A+
Sbjct: 298 RKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAV 356
>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
Length = 418
Score = 157 bits (398), Expect = 5e-38
Identities = 83/239 (34%), Positives = 140/239 (58%), Gaps = 3/239 (1%)
Query: 824 ASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPP 883
+S+ + + D+ + IGG+ +Q + + ++LP + EL+ + I G+L+YGPP
Sbjct: 149 SSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPP 208
Query: 884 GTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFE 943
G GKT+LA +A + FI V G E + KY+G + VRD+F A+ P I+F DE +
Sbjct: 209 GCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEID 268
Query: 944 SIAPRRGHDNTGV---TDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLD 1000
+IA +R TG R++ +LL Q+DG + V V+ AT+R D +DPALLRPGRLD
Sbjct: 269 AIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLD 328
Query: 1001 KCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
+ + P PD+ + I + ++ + L+++VDL+ + D +GAD+ ++ + + A+
Sbjct: 329 RKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAV 387
>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
Length = 797
Score = 152 bits (385), Expect = 2e-36
Identities = 89/233 (38%), Positives = 128/233 (54%), Gaps = 14/233 (6%)
Query: 836 DLGWDKIGGLHEVRQILMDTIQL---PAKYPELFANLPIRQRTGILLYGPPGTGKTLLAG 892
D+ + + G E + +M+ + P +Y +L A +P G +L GPPGTGKTLLA
Sbjct: 304 DVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIP----KGAILTGPPGTGKTLLAK 359
Query: 893 VIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHD 952
A E+ + FI+V G E L ++G VRD+F A+ PCILF DE +++ +RG
Sbjct: 360 ATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRG 419
Query: 953 NTG---VTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPD 1009
N G + +NQLL ++DG V +LA T+RPD++DPALLRPGR D+ ++ PPD
Sbjct: 420 NFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPD 479
Query: 1010 QVSRLEILNV----LSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEA 1058
R I V L L D + +AS+T F+GAD+ + A L A
Sbjct: 480 IKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIA 532
>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
Length = 1458
Score = 152 bits (385), Expect = 2e-36
Identities = 101/302 (33%), Positives = 150/302 (49%), Gaps = 13/302 (4%)
Query: 771 HVAKETGGFVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLP------A 824
H+ ++ + D T + R S+ R + + + G L A
Sbjct: 324 HIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGA 383
Query: 825 SLRSVN-LHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPP 883
SL V+ ++ + + +D IGGL L + + P YPE+F I+ G L YGPP
Sbjct: 384 SLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPP 443
Query: 884 GTGKTLLAGVIARE-----SRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILF 938
GTGKTL+A +A E ++ F KG + LSK++G SE+ +R +F +A +P I+F
Sbjct: 444 GTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIF 503
Query: 939 FDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGR 998
FDE + +AP R + +V+ LL +DG++ + V+ AT+R D IDPAL RPGR
Sbjct: 504 FDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGR 563
Query: 999 LDKCVYCPPPDQVSRLEILNV-LSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLE 1057
D+ PDQ +R IL + D P D L +A + GAD+KAL A L
Sbjct: 564 FDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALI 623
Query: 1058 AL 1059
AL
Sbjct: 624 AL 625
Score = 47.8 bits (112), Expect = 7e-05
Identities = 65/247 (26%), Positives = 107/247 (43%), Gaps = 29/247 (11%)
Query: 596 LLTGGKGSGKSTLAKAICKEAF--DKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVW 653
L G G+GK+ +A+A+ E DK A R L K + ++ L + F +A
Sbjct: 438 LFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCL-SKWVGESERQLRLLFDQAYL 496
Query: 654 MQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQ 713
M+PS++ D++D +A P D + S + L ++ + G +V + AT++
Sbjct: 497 MRPSIIFFDEIDGLA-----PVRSSRQDQIHSS-IVSTLLALMDGLDNRGEIVVIGATNR 550
Query: 714 SQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDIN-KFTDLDLQHV 772
S+ P L + F P+Q+ R IL + D N K +D L +
Sbjct: 551 LD-SIDPAL---RRPGRFDREFLFNLPDQKARKHILQIHTR-----DWNPKLSDAFLGEL 601
Query: 773 AKETGGFVARDFTVLVDRAIHSRLSR---QSISTREKL-------VLTTLDFQKALRGFL 822
A++ G+ D L A L R Q ++ KL VL+ DF A++ +
Sbjct: 602 AEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNIV 661
Query: 823 PASLRSV 829
PAS R+V
Sbjct: 662 PASQRAV 668
>gi|156564401 vesicle-fusing ATPase [Homo sapiens]
Length = 744
Score = 149 bits (375), Expect = 2e-35
Identities = 93/223 (41%), Positives = 137/223 (61%), Gaps = 23/223 (10%)
Query: 863 PELFANLPIRQRTGILLYGPPGTGKTLLAGVI-----ARESRMNFISVKGPELLSKYIGA 917
PE+ + + GILLYGPPG GKTLLA I ARE ++ V GPE+L+KY+G
Sbjct: 242 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKV----VNGPEILNKYVGE 297
Query: 918 SEQAVRDIFIRAQAAKPC--------ILFFDEFESIAPRRGH--DNTGVTDRVVNQLLTQ 967
SE +R +F A+ + I+ FDE ++I +RG +TGV D VVNQLL++
Sbjct: 298 SEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSK 357
Query: 968 LDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLP-- 1025
+DGVE L + V+ T+RPDLID ALLRPGRL+ + PD+ RL+IL++ + +
Sbjct: 358 IDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGH 417
Query: 1026 --LADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSS 1066
L+ DVD++ +A T +F+GA+L+ L+ AQ A++ + +S
Sbjct: 418 QLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKAS 460
Score = 47.8 bits (112), Expect = 7e-05
Identities = 56/195 (28%), Positives = 90/195 (46%), Gaps = 24/195 (12%)
Query: 766 DLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQ-SISTREKLVLTTLDFQKALRGFLPA 824
D+D++ +A ET F + LV A + ++R ST+ ++ + + + RG A
Sbjct: 423 DVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLA 482
Query: 825 SLRSVNLHKP------RDLGWDKIGGLHE----VRQILMDTIQLPAKYPELFANLPIRQR 874
SL N KP D + G+ + V ++L D +L + + P+
Sbjct: 483 SLE--NDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDG-ELLVQQTKNSDRTPL--- 536
Query: 875 TGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASE----QAVRDIFIRAQ 930
+LL GPP +GKT LA IA ES FI + P+ K IG SE QA++ IF A
Sbjct: 537 VSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD---KMIGFSETAKCQAMKKIFDDAY 593
Query: 931 AAKPCILFFDEFESI 945
++ + D+ E +
Sbjct: 594 KSQLSCVVVDDIERL 608
>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
Length = 1390
Score = 148 bits (374), Expect = 3e-35
Identities = 91/243 (37%), Positives = 133/243 (54%), Gaps = 7/243 (2%)
Query: 824 ASLRSVN-LHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGP 882
ASL V+ + + +D +GGL L + + P YPE+F I+ G L YGP
Sbjct: 409 ASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGP 468
Query: 883 PGTGKTLLAGVIARE-----SRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCIL 937
PGTGKTL+A +A E R+ F KG + LSK++G SE+ +R +F +A +P I+
Sbjct: 469 PGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSII 528
Query: 938 FFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPG 997
FFDE + +AP R + +V+ LL +DG++ + V+ AT+R D IDPAL RPG
Sbjct: 529 FFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPG 588
Query: 998 RLDKCVYCPPPDQVSRLEILNV-LSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQL 1056
R D+ PD+ +R EIL + D P D L+ +A + GAD+K++ A L
Sbjct: 589 RFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAAL 648
Query: 1057 EAL 1059
AL
Sbjct: 649 CAL 651
Score = 49.7 bits (117), Expect = 2e-05
Identities = 64/246 (26%), Positives = 108/246 (43%), Gaps = 27/246 (10%)
Query: 596 LLTGGKGSGKSTLAKAICKEAF--DKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVW 653
L G G+GK+ +A+A+ E DK A R L K + ++ L + F +A
Sbjct: 464 LFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCL-SKWVGESERQLRLLFDQAYQ 522
Query: 654 MQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQ 713
M+PS++ D++D +A P D + S + L ++ S G +V + AT++
Sbjct: 523 MRPSIIFFDEIDGLA-----PVRSSRQDQIHSS-IVSTLLALMDGLDSRGEIVVIGATNR 576
Query: 714 SQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVA 773
S+ P L + F P++E R EIL ++ ++ F L+ +A
Sbjct: 577 LD-SIDPAL---RRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTF----LEELA 628
Query: 774 KETGGFVARDFTVLVDRAIHSRLSR---QSISTREKLVL-------TTLDFQKALRGFLP 823
+ G+ D + A L R Q +T EKL L + DF+ A++ +P
Sbjct: 629 ENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIP 688
Query: 824 ASLRSV 829
AS R+V
Sbjct: 689 ASQRAV 694
>gi|113426932 PREDICTED: similar to N-ethylmaleimide-sensitive factor
[Homo sapiens]
Length = 563
Score = 147 bits (372), Expect = 5e-35
Identities = 92/223 (41%), Positives = 137/223 (61%), Gaps = 23/223 (10%)
Query: 863 PELFANLPIRQRTGILLYGPPGTGKTLLAGVI-----ARESRMNFISVKGPELLSKYIGA 917
PE+ + + GILLYGPPG GKTLLA I ARE ++ V GPE+L+KY+G
Sbjct: 315 PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKV----VNGPEILNKYVGE 370
Query: 918 SEQAVRDIFIRAQAAKPC--------ILFFDEFESIAPRRGH--DNTGVTDRVVNQLLTQ 967
SE +R +F A+ + I+ FDE ++I +RG +TGV D VVNQLL++
Sbjct: 371 SEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSK 430
Query: 968 LDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLP-- 1025
+DG+E L + V+ T+RPDLID ALLRPGRL+ + PD+ RL+IL++ + +
Sbjct: 431 IDGMEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGH 490
Query: 1026 --LADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSS 1066
L+ DVD++ +A T +F+GA+L+ L+ AQ A++ + +S
Sbjct: 491 QLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKAS 533
>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
Length = 491
Score = 147 bits (371), Expect = 6e-35
Identities = 94/229 (41%), Positives = 128/229 (55%), Gaps = 11/229 (4%)
Query: 839 WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898
WD I L E +++L + + LP PE F + R G+L+ GPPGTGKTLLA +A E
Sbjct: 208 WDDIADLVEAKKLLKEAVVLPMWMPEFFKGIR-RPWKGVLMVGPPGTGKTLLAKAVATEC 266
Query: 899 RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRG-HDNTGVT 957
+ F +V L SKY G SE+ VR +F A+ P +F DE +SI RRG + +
Sbjct: 267 KTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEAS 326
Query: 958 DRVVNQLLTQLDGVEGL-------QGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQ 1010
RV +LL Q+DGV G + V VLAAT+ P ID AL R RL+K +Y P P
Sbjct: 327 RRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPSA 384
Query: 1011 VSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
R E+L + L LADDVDL +A + ++GAD+ + +A L A+
Sbjct: 385 KGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAM 433
Score = 39.3 bits (90), Expect = 0.024
Identities = 53/240 (22%), Positives = 98/240 (40%), Gaps = 32/240 (13%)
Query: 595 LLLTGGKGSGKSTLAKAI---CKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEA 651
+L+ G G+GK+ LAKA+ CK F V L K +K + + F A
Sbjct: 245 VLMVGPPGTGKTLLAKAVATECKTTF-------FNVSSSTLTSKYRGESEKLVRLLFEMA 297
Query: 652 VWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALN-DMIKEFISMGSLVALIA 710
+ P+ + +D++D I E + V+++ L E +V ++A
Sbjct: 298 RFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLA 357
Query: 711 TSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQ 770
+ + L I+ I P+ + R E+L ++ ++ D+DL
Sbjct: 358 ATNFPWDIDEALRRRLEKRIY-----IPLPSAKGREELLRISLR-----ELELADDVDLA 407
Query: 771 HVAKETGGFVARDFT-VLVDRAIHSRLSR---------QSISTREKLVLTTL-DFQKALR 819
+A+ G+ D T V D ++ + R +++S E + TT+ DF+ AL+
Sbjct: 408 SIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALK 467
>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
Length = 773
Score = 142 bits (358), Expect = 2e-33
Identities = 80/225 (35%), Positives = 127/225 (56%), Gaps = 2/225 (0%)
Query: 835 RDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVI 894
+++ ++ + G+ E +Q L + ++ K P+ F L + GILL GPPGTGKTLLA +
Sbjct: 334 KNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAV 392
Query: 895 ARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNT 954
A E+ + F G E ++G +R++F A+A PC++F DE +S+ +R
Sbjct: 393 AGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPM 452
Query: 955 GVTDR-VVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSR 1013
R +NQLL ++DG + +GV ++ AT+ P+ +D AL+RPGR D V P PD R
Sbjct: 453 HPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGR 512
Query: 1014 LEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEA 1058
EIL + + VD + +A T F+GA+L+ L+ A L+A
Sbjct: 513 TEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKA 557
>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
Length = 716
Score = 142 bits (358), Expect = 2e-33
Identities = 80/225 (35%), Positives = 127/225 (56%), Gaps = 2/225 (0%)
Query: 835 RDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVI 894
+++ ++ + G+ E +Q L + ++ K P+ F L + GILL GPPGTGKTLLA +
Sbjct: 277 KNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAV 335
Query: 895 ARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNT 954
A E+ + F G E ++G +R++F A+A PC++F DE +S+ +R
Sbjct: 336 AGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPM 395
Query: 955 GVTDR-VVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSR 1013
R +NQLL ++DG + +GV ++ AT+ P+ +D AL+RPGR D V P PD R
Sbjct: 396 HPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGR 455
Query: 1014 LEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEA 1058
EIL + + VD + +A T F+GA+L+ L+ A L+A
Sbjct: 456 TEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKA 500
>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 140 bits (354), Expect = 6e-33
Identities = 99/303 (32%), Positives = 153/303 (50%), Gaps = 27/303 (8%)
Query: 839 WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898
WD I L E +++L + + LP P+ F + R G+L+ GPPGTGKT+LA +A E
Sbjct: 207 WDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTMLAKAVATEC 265
Query: 899 RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRG-HDNTGVT 957
F +V L SKY G SE+ VR +F A+ P +F DE +SI RRG D +
Sbjct: 266 GTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEAS 325
Query: 958 DRVVNQLLTQLDGVEGL-------QGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQ 1010
RV ++LL Q+DGV G + V VLAAT+ P ID AL R RL+K +Y P P
Sbjct: 326 RRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPTA 383
Query: 1011 VSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQD 1070
R E+L + + L D+ L+ +A + ++GAD+ + +A L A+ + ++
Sbjct: 384 KGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPEE 443
Query: 1071 GSSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRLYF 1130
+ S +L + + GD E L + S+ +++ K+ + + F
Sbjct: 444 IRALSKEELQMPV------------TKGDFELALKKIAKSVSAADL----EKYEKWMVEF 487
Query: 1131 GSS 1133
GS+
Sbjct: 488 GSA 490
Score = 40.0 bits (92), Expect = 0.014
Identities = 56/252 (22%), Positives = 104/252 (41%), Gaps = 29/252 (11%)
Query: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWM 654
+L+ G G+GK+ LAKA+ E V L K +K + + F A +
Sbjct: 244 VLMVGPPGTGKTMLAKAVATEC----GTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFY 299
Query: 655 QPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALN-DMIKEFISMGSLVALIATSQ 713
P+ + +D++D I + + V+S+ L E +V ++A +
Sbjct: 300 APTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATN 359
Query: 714 SQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEIL-CNVIKNKLDCDINKFTDLDLQHV 772
+ L I+ I P + R E+L N+ + +LD D+ L+ +
Sbjct: 360 FPWDIDEALRRRLEKRIY-----IPLPTAKGRAELLKINLREVELD------PDIQLEDI 408
Query: 773 AKETGGF-------VARDFTVLVDRAIHSRLSRQSISTREK----LVLTTLDFQKALRGF 821
A++ G+ V RD +++ R + LS + I K + +T DF+ AL+
Sbjct: 409 AEKIEGYSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKK- 467
Query: 822 LPASLRSVNLHK 833
+ S+ + +L K
Sbjct: 468 IAKSVSAADLEK 479
>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 140 bits (354), Expect = 6e-33
Identities = 99/303 (32%), Positives = 153/303 (50%), Gaps = 27/303 (8%)
Query: 839 WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898
WD I L E +++L + + LP P+ F + R G+L+ GPPGTGKT+LA +A E
Sbjct: 207 WDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTMLAKAVATEC 265
Query: 899 RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRG-HDNTGVT 957
F +V L SKY G SE+ VR +F A+ P +F DE +SI RRG D +
Sbjct: 266 GTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEAS 325
Query: 958 DRVVNQLLTQLDGVEGL-------QGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQ 1010
RV ++LL Q+DGV G + V VLAAT+ P ID AL R RL+K +Y P P
Sbjct: 326 RRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPTA 383
Query: 1011 VSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQD 1070
R E+L + + L D+ L+ +A + ++GAD+ + +A L A+ + ++
Sbjct: 384 KGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPEE 443
Query: 1071 GSSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRLYF 1130
+ S +L + + GD E L + S+ +++ K+ + + F
Sbjct: 444 IRALSKEELQMPV------------TKGDFELALKKIAKSVSAADL----EKYEKWMVEF 487
Query: 1131 GSS 1133
GS+
Sbjct: 488 GSA 490
Score = 40.0 bits (92), Expect = 0.014
Identities = 56/252 (22%), Positives = 104/252 (41%), Gaps = 29/252 (11%)
Query: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWM 654
+L+ G G+GK+ LAKA+ E V L K +K + + F A +
Sbjct: 244 VLMVGPPGTGKTMLAKAVATEC----GTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFY 299
Query: 655 QPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALN-DMIKEFISMGSLVALIATSQ 713
P+ + +D++D I + + V+S+ L E +V ++A +
Sbjct: 300 APTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATN 359
Query: 714 SQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEIL-CNVIKNKLDCDINKFTDLDLQHV 772
+ L I+ I P + R E+L N+ + +LD D+ L+ +
Sbjct: 360 FPWDIDEALRRRLEKRIY-----IPLPTAKGRAELLKINLREVELD------PDIQLEDI 408
Query: 773 AKETGGF-------VARDFTVLVDRAIHSRLSRQSISTREK----LVLTTLDFQKALRGF 821
A++ G+ V RD +++ R + LS + I K + +T DF+ AL+
Sbjct: 409 AEKIEGYSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKK- 467
Query: 822 LPASLRSVNLHK 833
+ S+ + +L K
Sbjct: 468 IAKSVSAADLEK 479
>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
Length = 795
Score = 137 bits (345), Expect = 7e-32
Identities = 80/230 (34%), Positives = 126/230 (54%), Gaps = 7/230 (3%)
Query: 835 RDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVI 894
+ + + + G+HE + + + + K PE F L + G LL GPPG GKTLLA +
Sbjct: 304 KGVSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAV 362
Query: 895 ARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNT 954
A E+++ F+++ GPE + G VR +F A+A PCI++ DE +++ +R +
Sbjct: 363 ATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMS 422
Query: 955 GVT----DRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQ 1010
G + ++ +NQLL ++DG+ V VLA+T+R D++D AL+RPGRLD+ V+ P
Sbjct: 423 GFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTL 482
Query: 1011 VSRLEILNVLSDSLPLADDVDL--QHVASVTDSFTGADLKALLYNAQLEA 1058
R EI SL L Q +A +T F+GAD+ + A L A
Sbjct: 483 QERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHA 532
Score = 40.4 bits (93), Expect = 0.011
Identities = 69/308 (22%), Positives = 126/308 (40%), Gaps = 46/308 (14%)
Query: 582 QLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQ 641
+ + L A + GALLL G G GK+ LAKA+ EA +V A+ G +
Sbjct: 333 RFLQLGAKVPKGALLL-GPPGCGKTLLAKAVATEA---------QVPFLAMAGPEFVEVI 382
Query: 642 KTLEVA-----FSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMI 696
L A F EA P +V +D++D + + + + LN ++
Sbjct: 383 GGLGAARVRSLFKEARARAPCIVYIDEIDAVG-----KKRSTTMSGFSNTEEEQTLNQLL 437
Query: 697 KEFISMGSL--VALIATSQSQQSLHPLLVSAQGV--HIFQCVQHIQPPNQEQRCEILCNV 752
E MG+ V ++A++ L L+ + H+F I P ++R EI
Sbjct: 438 VEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVF-----IDLPTLQERREIFEQH 492
Query: 753 IKNKLDCDINKFTDLDLQHVAKETGGFVARDF-TVLVDRAIHSRLSRQSISTREKLVLTT 811
+K+ + + + Q +A+ T GF D + + A+H+ +R+ ++ + T
Sbjct: 493 LKS---LKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHA--AREGHTS-----VHT 542
Query: 812 LDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPI 871
L+F+ A+ L + + + + K+ HE L+ + ++ E + I
Sbjct: 543 LNFEYAVERVLAGTAKKSKILSKEE---QKVVAFHESGHALVGWM---LEHTEAVMKVSI 596
Query: 872 RQRTGILL 879
RT L
Sbjct: 597 TPRTNAAL 604
>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
Length = 437
Score = 134 bits (337), Expect = 6e-31
Identities = 77/233 (33%), Positives = 134/233 (57%), Gaps = 7/233 (3%)
Query: 828 SVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGK 887
+V + KP ++ W+ + GL ++ L + + LP K+P LF R GILL+GPPGTGK
Sbjct: 116 AVVMEKP-NIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWR-GILLFGPPGTGK 173
Query: 888 TLLAGVIARE-SRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIA 946
+ LA +A E + F SV +L+SK++G SE+ V+++F A+ KP I+F DE +S+
Sbjct: 174 SYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLC 233
Query: 947 PRRGHDNTGVTDRVVNQLLTQLDGV-EGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYC 1005
R + + R+ + L Q+ GV G VL AT+ P ++D A+ R R +K +Y
Sbjct: 234 GSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYI 291
Query: 1006 PPPDQVSRLEILNVLSDSLP-LADDVDLQHVASVTDSFTGADLKALLYNAQLE 1057
P P++ +R ++ + S P D ++ +A T+ ++GAD+ ++ ++ ++
Sbjct: 292 PLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQ 344
Score = 44.3 bits (103), Expect = 8e-04
Identities = 50/214 (23%), Positives = 97/214 (45%), Gaps = 18/214 (8%)
Query: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWM 654
+LL G G+GKS LAKA+ EA + V D L K L +K ++ F A
Sbjct: 163 ILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSD---LMSKWLGESEKLVKNLFELARQH 219
Query: 655 QPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQS 714
+PS++ +D++D + G +E+ +A + + + + G+LV L AT+
Sbjct: 220 KPSIIFIDEVDSLCG----SRNENESEAARRIKTEFLVQMQGVGNNNDGTLV-LGATN-- 272
Query: 715 QQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAK 774
P ++ + F+ +I P + R + + + L + TD ++ +A+
Sbjct: 273 ----IPWVLDSAIRRRFEKRIYIPLPEEAARAQ----MFRLHLGSTPHNLTDANIHELAR 324
Query: 775 ETGGFVARDFTVLVDRAIHSRLSRQSISTREKLV 808
+T G+ D +++V ++ + + +T K V
Sbjct: 325 KTEGYSGADISIIVRDSLMQPVRKVQSATHFKKV 358
>gi|40806170 spastin isoform 2 [Homo sapiens]
Length = 584
Score = 132 bits (333), Expect = 2e-30
Identities = 83/221 (37%), Positives = 123/221 (55%), Gaps = 6/221 (2%)
Query: 839 WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898
+D I G +Q L + + LP+ PELF L R G+LL+GPPG GKT+LA +A ES
Sbjct: 309 FDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPAR-GLLLFGPPGNGKTMLAKAVAAES 367
Query: 899 RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTD 958
F ++ L SKY+G E+ VR +F A+ +P I+F DE +S+ R +
Sbjct: 368 NATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASR 427
Query: 959 RVVNQLLTQLDGVE--GLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEI 1016
R+ + L + DGV+ G V V+ AT+RP +D A+LR R K VY P++ +RL +
Sbjct: 428 RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLL 485
Query: 1017 L-NVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQL 1056
L N+L +L +A +TD ++G+DL AL +A L
Sbjct: 486 LKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAAL 526
Score = 51.6 bits (122), Expect = 5e-06
Identities = 58/213 (27%), Positives = 97/213 (45%), Gaps = 30/213 (14%)
Query: 586 LVAGLRNGA--LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKT 643
L GLR A LLL G G+GK+ LAKA+ E+ +A + +L K + +K
Sbjct: 335 LFTGLRAPARGLLLFGPPGNGKTMLAKAVAAES----NATFFNISAASLTSKYVGEGEKL 390
Query: 644 LEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMG 703
+ F+ A +QPS++ +D++D + EH+ S+RL + + EF +
Sbjct: 391 VRALFAVARELQPSIIFIDEVDSLLCERREGEHD------ASRRLK---TEFLIEFDGVQ 441
Query: 704 S-----LVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLD 758
S ++ + AT++ Q+ +L F ++ PN+E R +L KN L
Sbjct: 442 SAGDDRVLVMGATNRPQELDEAVL------RRFIKRVYVSLPNEETRLLLL----KNLLC 491
Query: 759 CDINKFTDLDLQHVAKETGGFVARDFTVLVDRA 791
+ T +L +A+ T G+ D T L A
Sbjct: 492 KQGSPLTQKELAQLARMTDGYSGSDLTALAKDA 524
>gi|11875211 spastin isoform 1 [Homo sapiens]
Length = 616
Score = 132 bits (333), Expect = 2e-30
Identities = 83/221 (37%), Positives = 123/221 (55%), Gaps = 6/221 (2%)
Query: 839 WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898
+D I G +Q L + + LP+ PELF L R G+LL+GPPG GKT+LA +A ES
Sbjct: 341 FDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPAR-GLLLFGPPGNGKTMLAKAVAAES 399
Query: 899 RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTD 958
F ++ L SKY+G E+ VR +F A+ +P I+F DE +S+ R +
Sbjct: 400 NATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASR 459
Query: 959 RVVNQLLTQLDGVE--GLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEI 1016
R+ + L + DGV+ G V V+ AT+RP +D A+LR R K VY P++ +RL +
Sbjct: 460 RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLL 517
Query: 1017 L-NVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQL 1056
L N+L +L +A +TD ++G+DL AL +A L
Sbjct: 518 LKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAAL 558
Score = 51.6 bits (122), Expect = 5e-06
Identities = 58/213 (27%), Positives = 97/213 (45%), Gaps = 30/213 (14%)
Query: 586 LVAGLRNGA--LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKT 643
L GLR A LLL G G+GK+ LAKA+ E+ +A + +L K + +K
Sbjct: 367 LFTGLRAPARGLLLFGPPGNGKTMLAKAVAAES----NATFFNISAASLTSKYVGEGEKL 422
Query: 644 LEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMG 703
+ F+ A +QPS++ +D++D + EH+ S+RL + + EF +
Sbjct: 423 VRALFAVARELQPSIIFIDEVDSLLCERREGEHD------ASRRLK---TEFLIEFDGVQ 473
Query: 704 S-----LVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLD 758
S ++ + AT++ Q+ +L F ++ PN+E R +L KN L
Sbjct: 474 SAGDDRVLVMGATNRPQELDEAVL------RRFIKRVYVSLPNEETRLLLL----KNLLC 523
Query: 759 CDINKFTDLDLQHVAKETGGFVARDFTVLVDRA 791
+ T +L +A+ T G+ D T L A
Sbjct: 524 KQGSPLTQKELAQLARMTDGYSGSDLTALAKDA 556
>gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]
Length = 415
Score = 131 bits (330), Expect = 4e-30
Identities = 80/243 (32%), Positives = 127/243 (52%), Gaps = 21/243 (8%)
Query: 843 GGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNF 902
GGL Q + ++++LP +PE + + + G++L GPPGT F
Sbjct: 175 GGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGTA--------------TF 220
Query: 903 ISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVN 962
+ V G EL+ KY+G + VR +F A+ P I+F DE E+I +R N+G +R +
Sbjct: 221 LRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSG-GEREIQ 279
Query: 963 Q------LLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEI 1016
Q LL QL G + + V V+ AT + + +DP L+RPGR+DK + PD+ ++ I
Sbjct: 280 QTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDEKTKKHI 339
Query: 1017 LNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSD 1076
+ + + LA+DV L + D F+GAD+KA+ A L AL + + +D S +
Sbjct: 340 FQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTEAGLMALREHRMKATNEDFKKSIE 399
Query: 1077 SDL 1079
S L
Sbjct: 400 SVL 402
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,381,673
Number of Sequences: 37866
Number of extensions: 2184353
Number of successful extensions: 7121
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 6906
Number of HSP's gapped (non-prelim): 158
length of query: 1283
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1169
effective length of database: 13,930,794
effective search space: 16285098186
effective search space used: 16285098186
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.