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Search of human proteins with 4505237
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
(466 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens] 934 0.0
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 533 e-151
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 518 e-147
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 510 e-145
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens] 357 1e-98
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens] 348 5e-96
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 284 1e-76
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 273 2e-73
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens] 256 4e-68
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 162 6e-40
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 159 5e-39
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 156 3e-38
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 156 3e-38
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 153 4e-37
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 150 3e-36
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 150 3e-36
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 149 4e-36
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 147 3e-35
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 146 4e-35
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 141 1e-33
gi|226874833 guanylate kinase 1 isoform b [Homo sapiens] 107 3e-23
gi|226874831 guanylate kinase 1 isoform a [Homo sapiens] 107 3e-23
gi|4504221 guanylate kinase 1 isoform b [Homo sapiens] 107 3e-23
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 57 3e-08
gi|95089461 discs large homolog 5 [Homo sapiens] 57 4e-08
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 54 4e-07
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 54 4e-07
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 50 4e-06
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 49 7e-06
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 49 7e-06
>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
Length = 466
Score = 934 bits (2413), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 1 MTLKASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQ 60
MTLKASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQ
Sbjct: 1 MTLKASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQ 60
Query: 61 VKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEI 120
VKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEI
Sbjct: 61 VKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEI 120
Query: 121 NGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCK 180
NGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCK
Sbjct: 121 NGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCK 180
Query: 181 EAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESAGLIPSPELQEWRVASMAQSAPSEAP 240
EAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESAGLIPSPELQEWRVASMAQSAPSEAP
Sbjct: 181 EAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESAGLIPSPELQEWRVASMAQSAPSEAP 240
Query: 241 SCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKN 300
SCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKN
Sbjct: 241 SCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKN 300
Query: 301 ALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFG 360
ALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFG
Sbjct: 301 ALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFG 360
Query: 361 TKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKDSE 420
TKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKDSE
Sbjct: 361 TKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKDSE 420
Query: 421 AIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY 466
AIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY
Sbjct: 421 AIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY 466
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 533 bits (1374), Expect = e-151
Identities = 252/437 (57%), Positives = 345/437 (78%), Gaps = 18/437 (4%)
Query: 48 YTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHR 107
Y NG + + + V +VRL+QF+K T+EPMGITLK+NE C VARI+HGGMIHR
Sbjct: 461 YLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHR 520
Query: 108 QGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR------LPAL-- 159
QG+LHVGDEI EING +V N +V+QLQK ++E +G I+ K++P+ +++ LP+
Sbjct: 521 QGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQ 580
Query: 160 ----QMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESA 215
Q+++RAQF+YDP KD+LIPCKEAG++F GDIIQII+KDD NWWQG++E S +A
Sbjct: 581 PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTA 640
Query: 216 GLIPSPELQEWRVA--SMAQSAPSEAPSCSPFGKKKK-YKDKYLAKHSSIFDQLDVVSYE 272
GLIPSPELQEWRVA +M ++ + SC+ FGKKKK YKDKYLAKH+++FDQLD+V+YE
Sbjct: 641 GLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYE 700
Query: 273 EVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYH 332
EVV+LPAFKRKTLVL+GA GVGR HIKN L++++P++F YP+P+TTRPP+K EE+GK Y+
Sbjct: 701 EVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYY 760
Query: 333 FISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAE 392
F+S ++M ++IS NE+LE+GS++ M+GTK ET+ +IH+Q IAILD+EPQ LK++RTAE
Sbjct: 761 FVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAE 820
Query: 393 LSPFIVFIAP---TDQGTQTEALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEA 449
+PF+VFIA T + E+LQ+LQK+S+ ++ YAHYFDL+++NN +DET++ L+EA
Sbjct: 821 FAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEA 880
Query: 450 FDQACSSPQWVPVSWVY 466
+ C++PQWVPVSWVY
Sbjct: 881 VELVCTAPQWVPVSWVY 897
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 518 bits (1334), Expect = e-147
Identities = 248/437 (56%), Positives = 340/437 (77%), Gaps = 23/437 (5%)
Query: 48 YTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHR 107
Y NG + + + V +VRL+QF+K T+EPMGITLK+NE C VARI+HGGMIHR
Sbjct: 467 YLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHR 526
Query: 108 QGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR------LPAL-- 159
QG+LHVGDEI EING +V N +V+QLQK ++E +G I+ K++P+ +++ LP+
Sbjct: 527 QGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQ 586
Query: 160 ----QMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESA 215
Q+++RAQF+YDP KD+LIPCKEAG++F GDIIQII+KDD NWWQG++E S +A
Sbjct: 587 PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTA 646
Query: 216 GLIPSPELQEWRVA--SMAQSAPSEAPSCSPFGKKKK-YKDKYLAKHSSIFDQLDVVSYE 272
GLIPSPELQEWRVA +M ++ + SC+ FGKKKK YKDKYLAKH++ D+V+YE
Sbjct: 647 GLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNA-----DLVTYE 701
Query: 273 EVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYH 332
EVV+LPAFKRKTLVL+GA GVGR HIKN L++++P++F YP+P+TTRPP+K EE+GK Y+
Sbjct: 702 EVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYY 761
Query: 333 FISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAE 392
F+S ++M ++IS NE+LE+GS++ M+GTK ET+ +IH+Q IAILD+EPQ LK++RTAE
Sbjct: 762 FVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAE 821
Query: 393 LSPFIVFIAP---TDQGTQTEALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEA 449
+PF+VFIA T + E+LQ+LQK+S+ ++ YAHYFDL+++NN +DET++ L+EA
Sbjct: 822 FAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEA 881
Query: 450 FDQACSSPQWVPVSWVY 466
+ C++PQWVPVSWVY
Sbjct: 882 VELVCTAPQWVPVSWVY 898
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 510 bits (1314), Expect = e-145
Identities = 250/460 (54%), Positives = 338/460 (73%), Gaps = 46/460 (10%)
Query: 48 YTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHR 107
Y NG + + + V +VRL+QF+K T+EPMGITLK+NE C VARI+HGGMIHR
Sbjct: 467 YLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHR 526
Query: 108 QGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIP----------------- 150
QG+LHVGDEI EING +V N +V+QLQK ++E +G I+ K++P
Sbjct: 527 QGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTS 586
Query: 151 ------------NQQSRLPAL------QMFMRAQFDYDPKKDNLIPCKEAGLKFATGDII 192
N S LP+ Q+++RAQF+YDP KD+LIPCKEAG++F GDII
Sbjct: 587 RQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDII 646
Query: 193 QIINKDDSNWWQGRVEGSSKESAGLIPSPELQEWRVA--SMAQSAPSEAPSCSPFGKKKK 250
QII+KDD NWWQG++E S +AGLIPSPELQEWRVA +M ++ + SC+ FGKKKK
Sbjct: 647 QIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKK 706
Query: 251 -YKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEK 309
YKDKYLAKH++ D+V+YEEVV+LPAFKRKTLVL+GA GVGR HIKN L++++P++
Sbjct: 707 QYKDKYLAKHNA-----DLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDR 761
Query: 310 FVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQI 369
F YP+P+TTRPP+K EE+GK Y+F+S ++M ++IS NE+LE+GS++ M+GTK ET+ +I
Sbjct: 762 FAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKI 821
Query: 370 HKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP---TDQGTQTEALQQLQKDSEAIRSQY 426
H+Q IAILD+EPQ LK++RTAE +PF+VFIA T + E+LQ+LQK+S+ ++ Y
Sbjct: 822 HEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTY 881
Query: 427 AHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY 466
AHYFDL+++NN +DET++ L+EA + C++PQWVPVSWVY
Sbjct: 882 AHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY 921
>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
Length = 540
Score = 357 bits (916), Expect = 1e-98
Identities = 183/421 (43%), Positives = 266/421 (63%), Gaps = 25/421 (5%)
Query: 66 VRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNV 125
V +R++ K EP+G+T ++ E +ARILHGGMI RQG LHVGD I E+NG V
Sbjct: 125 VDAIRILGIHKRAGEPLGVTFRV-ENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEV 183
Query: 126 TNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLK 185
N+ +LQ+ +K G ++LK++P+ + + Q+F++ FDY+P DNLIPCKEAGLK
Sbjct: 184 GNNP-KELQELLKNISGSVTLKILPSYRDTITPQQVFVKCHFDYNPYNDNLIPCKEAGLK 242
Query: 186 FATGDIIQIINKDDSNWWQGR--VEGSSKESAGLIPSPELQEWRVASMAQSAPSEAPSCS 243
F+ G+I+QI+N++D NWWQ EG S AGLIPS L+E R A + + + P C
Sbjct: 243 FSKGEILQIVNREDPNWWQASHVKEGGS---AGLIPSQFLEEKRKAFVRRDWDNSGPFCG 299
Query: 244 PFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALL 303
KKK K YL ++ FD+ ++ YEEV ++P F+RKTLVLIGA GVGR +KN +
Sbjct: 300 TISSKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPPFQRKTLVLIGAQGVGRRSLKNRFI 359
Query: 304 SQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKF 363
NP +F VP+T+R PR+ E+DG+ Y F+S EM +I A ++LE G Y+GN++GTK
Sbjct: 360 VLNPTRFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHGEYEGNLYGTKI 419
Query: 364 ETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP-------------TDQGTQTE 410
+++ ++ + + ILD+ PQ LK++RT+E P++VFIA D G T+
Sbjct: 420 DSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGITTK 479
Query: 411 AL--QQLQK---DSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWV 465
L L+K +S I+ Y HYFDL ++N+ +D+ +KLQ A ++ PQWVP+SWV
Sbjct: 480 LLTDSDLKKTVDESARIQRAYNHYFDLIIINDNLDKAFEKLQTAIEKLRMEPQWVPISWV 539
Query: 466 Y 466
Y
Sbjct: 540 Y 540
>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
Length = 552
Score = 348 bits (894), Expect = 5e-96
Identities = 189/468 (40%), Positives = 282/468 (60%), Gaps = 30/468 (6%)
Query: 23 LEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRK--VRLIQFEKVTEE 80
L H+LQ+ +++ ++V Y P+PG Q V VR++ K E
Sbjct: 91 LAHILQE-PHFQSLLETHDSVASKTYETPPPSPGLDPTFSNQPVPPDAVRMVGIRKTAGE 149
Query: 81 PMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKET 140
+G+T ++ E +ARILHGGM+ +QG LHVGD I E+NG V + LQ+ ++
Sbjct: 150 HLGVTFRV-EGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGSDP-RALQELLRNA 207
Query: 141 KGMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDS 200
G + LK++P+ Q Q+F++ FDYDP +D+LIPCKEAGL+F GD++QI+N+DD+
Sbjct: 208 SGSVILKILPSYQEPHLPRQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDA 267
Query: 201 NWWQG-RVEGSSKESAGLIPSPELQEWRVASMAQS---APSEAPSCSPFGKKKKYKDKYL 256
NWWQ VEG S AGLIPS L+E R A + + P+ C KKK + YL
Sbjct: 268 NWWQACHVEGGS---AGLIPSQLLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKKRMMYL 324
Query: 257 AKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPY 316
++ FD+ +++ YEEV R+P F+RKTLVLIGA GVGR +KN L+ +P+++ VPY
Sbjct: 325 TTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPY 384
Query: 317 TTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIA 376
T+R P+ SE +G+ Y F+S EM ++ A +LE G Y+GN++GT+ +++ + K+
Sbjct: 385 TSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVC 444
Query: 377 ILDIEPQTLKIVRTAELSPFIVFIAPTDQGT-----------------QTEA-LQQLQKD 418
+LD+ PQ +K++RTAE P++VFI D T TEA L++ ++
Sbjct: 445 VLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEE 504
Query: 419 SEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY 466
S I+ Y HYFDL LVN+ ++ T ++LQ A ++ + PQWVPVSWVY
Sbjct: 505 SSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 552
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 284 bits (726), Expect = 1e-76
Identities = 166/488 (34%), Positives = 259/488 (53%), Gaps = 48/488 (9%)
Query: 23 LEHLLQKRSRP--EAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEE 80
+ LL+ S+P +A+ +TV + Y P + V+ +RL++ E
Sbjct: 92 IRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVK----NRE 147
Query: 81 PMGITLKLNEKQSCT-VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKE 139
P+G T+K +E+ VARI+ GG R G +HVGDE+ E+NG V + +++ + + +
Sbjct: 148 PLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQ 207
Query: 140 TKGMISLKVIPNQQSRLPALQ--MFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINK 197
++G I+ K+IP + P+ + MF++A FDY+P +D IPCKEAGL F GDI+QI+++
Sbjct: 208 SQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQ 267
Query: 198 DDSNWWQGRVEGSSKESAGLIPSPELQEWRVAS-----MAQSAPSEAPSCSPFGK----- 247
DD+ WWQ + E + AGLIPS QE R+A + Q S F K
Sbjct: 268 DDATWWQAKHEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLS 327
Query: 248 ---KKKYKDKYLAKHSSIFDQLDVVSYEEVV---RLPAFKRKTLVLIGASGVGRSHIKNA 301
KK K Y K S +D DV +YEEV R K + +VL+G GVG + +K
Sbjct: 328 RKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRK 387
Query: 302 LLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGT 361
LL + + + VP+TTR R E DG EY FIS ++ N+F+E+G Y+ N +GT
Sbjct: 388 LLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGT 447
Query: 362 KFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP------------------- 402
++V + +NK+ +LD++P T+K +RT E P+++FI P
Sbjct: 448 SIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSR 507
Query: 403 TDQGT----QTEALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQ 458
DQG E Q++ K ++ + SQY H FD ++N+ + +L+ FD+ +
Sbjct: 508 DDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETH 567
Query: 459 WVPVSWVY 466
WVPVSW++
Sbjct: 568 WVPVSWLH 575
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 273 bits (699), Expect = 2e-73
Identities = 148/488 (30%), Positives = 261/488 (53%), Gaps = 35/488 (7%)
Query: 3 LKASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQVK 62
LK + G + L+ +++ LL + L +T++ S Q
Sbjct: 197 LKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYE------SIGQYG 250
Query: 63 GQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEING 122
G+ V+ VR+ EK + P+G T++ NE S ++RI+ GG + G LH GDE+LEING
Sbjct: 251 GETVKIVRI---EKARDIPLGATVR-NEMDSVIISRIVKGGAAEKSGLLHEGDEVLEING 306
Query: 123 TNVTNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQ---MFMRAQFDYDPKKDNLIPC 179
+ V+++ + + G ++ +IP+QQ + P + + ++A FDYDP D +PC
Sbjct: 307 IEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPC 366
Query: 180 KEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKES--AGLIPSPELQEWRVASMAQSAPS 237
+E GL F GDI+ +I+++D NWWQ EG AGL+P Q+ R A
Sbjct: 367 RELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEED 426
Query: 238 EAPS------CSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEV--VRLPAFKRKTLVLIG 289
+ P C+ KKK+ K Y A + +D ++++YEE+ PA +++ ++LIG
Sbjct: 427 KEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIG 486
Query: 290 ASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFL 349
G++ ++ L+++ ++F VP+TTR R E G++YHF+S + +I+A +F+
Sbjct: 487 PQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFI 546
Query: 350 EFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQ---- 405
E G ++ N++GT ++V Q+ KI +L + Q+LK +R ++L P+I+FIAP Q
Sbjct: 547 EHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLR 606
Query: 406 --------GTQTEALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSP 457
+ E L+++ + + + HYFD ++VN+ +D+ ++L ++ + P
Sbjct: 607 ALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEP 666
Query: 458 QWVPVSWV 465
QWVP +W+
Sbjct: 667 QWVPSTWL 674
>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
Length = 585
Score = 256 bits (653), Expect = 4e-68
Identities = 146/456 (32%), Positives = 241/456 (52%), Gaps = 58/456 (12%)
Query: 64 QEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTV-ARILHGGMIHRQGSLHVGDEILEING 122
+ V+ VRL++ +EP+G T++ +E V ARI+ GG R G +HVGDE+ E+NG
Sbjct: 133 ESVKIVRLVK----NKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNG 188
Query: 123 TNVTNHSVDQLQKAMKETKGMISLKVIP--NQQSRLPALQMFMRAQFDYDPKKDNLIPCK 180
V + D++ + + +++G I+LK+IP ++ RL ++FMRA F Y+P++D IPC+
Sbjct: 189 IAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKVFMRALFHYNPREDRAIPCQ 248
Query: 181 EAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESAGLIPSPELQEWRVA--SMAQSAPS- 237
EAGL F +++++++DD WWQ + G + AGLIPS QE R++ A + PS
Sbjct: 249 EAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKGFQERRLSYRRAAGTLPSP 308
Query: 238 ----EAPSCSPFGKKKKYKDKYLAKH-------------------------SSIFDQLDV 268
+ P P K+ + YL H SS + ++
Sbjct: 309 QSLRKPPYDQPCDKETCDCEGYLKGHYVAGLRRSFRLGCRERLGGSQEGKMSSGAESPEL 368
Query: 269 VSYEEVVRL---PAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSE 325
++YEEV R P + + +VLIG+ G +K ++++NP+ F VP+TTRP + E
Sbjct: 369 LTYEEVARYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHE 428
Query: 326 EDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTL 385
++G EYHF+S + ++ N+FLE G Y+ N++GT E + + +NK+ ++D+EP+ L
Sbjct: 429 KEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEAL 488
Query: 386 KIVRTAELSPFIVFIAPTDQGTQ----------------TEALQQLQKDSEAIRSQYAHY 429
K +RT+E P+I+F+ P Q + E Q++ + I Y H
Sbjct: 489 KQLRTSEFKPYIIFVKPAIQEKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHL 548
Query: 430 FDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWV 465
D LV + +L+ ++ WVPVSWV
Sbjct: 549 VDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVSWV 584
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 162 bits (410), Expect = 6e-40
Identities = 106/407 (26%), Positives = 191/407 (46%), Gaps = 46/407 (11%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
V+ IL GG G L GD IL +NG N+ N + +Q A+K +++ + P +
Sbjct: 411 VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEY 470
Query: 154 SRLPA--------------------------LQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
SR + +++RA FDYD +D+ +P + GL F+
Sbjct: 471 SRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSFS 528
Query: 188 TGDIIQIINKDDSNWWQGRV--EGSSKESAGLIPSPELQEWRVASMAQSAPSEAPSCSPF 245
GDI+ +IN D WWQ R+ E G+IPS + E + + ++ A +
Sbjct: 529 YGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIE 588
Query: 246 GKK--KKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALL 303
+ D Y + + ++SYE V R + ++++G + + + L+
Sbjct: 589 SNRDFPGLSDDYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPM---KDRVNDDLI 645
Query: 304 SQNPEKFVYPVPYTTRPPRKSEEDGKEYHF-ISTEEMTRNISANEFLEFGSYQGNMFGTK 362
S+ P KF VP+TTRP R +E DG++YHF +S E+M ++I N+F+E G + N++GT
Sbjct: 646 SEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTS 705
Query: 363 FETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP--------TDQGTQTEALQQ 414
++V + ++ K ILD+ +K ++ A+L P +FI P ++ E +
Sbjct: 706 IQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANK 765
Query: 415 LQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVP 461
+ + + ++ YF + + ++E K+++ + WVP
Sbjct: 766 IYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVP 812
Score = 42.4 bits (98), Expect = 0.001
Identities = 18/56 (32%), Positives = 32/56 (57%)
Query: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
S + +I+ GG + G L +GD +L +N TN+ + ++ ++K T M+ LKV
Sbjct: 254 SIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKV 309
Score = 30.8 bits (68), Expect = 2.7
Identities = 30/121 (24%), Positives = 49/121 (40%), Gaps = 12/121 (9%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR 155
+ +I+ GG G L V D +L +N +V+ + +A+KE ++ L V + R
Sbjct: 162 ITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVV----RRR 217
Query: 156 LPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESA 215
P + M P K G A G Q I D+S + +EG + +
Sbjct: 218 QPPPETIMEVNLLKGP--------KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKD 269
Query: 216 G 216
G
Sbjct: 270 G 270
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 159 bits (402), Expect = 5e-39
Identities = 116/439 (26%), Positives = 202/439 (46%), Gaps = 78/439 (17%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
V+ IL GG G L GD IL +NG N+ N + +Q A+K +++ + P +
Sbjct: 74 VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEY 133
Query: 154 SRLPA--------------------------LQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
SR + +++RA FDYD +D+ +P + GL F+
Sbjct: 134 SRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSFS 191
Query: 188 TGDIIQIINKDDSNWWQGRV--EGSSKESAGLIPSPELQEWRVASMAQSAPSEA------ 239
GDI+ +IN D WWQ R+ E G+IPS + E + + ++ A
Sbjct: 192 YGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIE 251
Query: 240 PSCSPFGKKKK----------YKDK-YLAKHSSIFDQ-----------------LDVVSY 271
+ S K+KK YK K +A+ SSI +Q ++SY
Sbjct: 252 SNRSIKTKRKKSFRLSRKFPFYKSKENMAQESSIQEQGVTSNTSDSESSSKGQEDAILSY 311
Query: 272 EEVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEY 331
E V R + ++++G + + + L+S+ P KF VP+TTRP R +E DG++Y
Sbjct: 312 EPVTRQEIHYARPVIILGPM---KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDY 368
Query: 332 HF-ISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRT 390
HF +S E+M ++I N+F+E G + N++GT ++V + ++ K ILD+ +K ++
Sbjct: 369 HFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQ 428
Query: 391 AELSPFIVFIAP--------TDQGTQTEALQQLQKDSEAIRSQYAHYFDLSLVNNGVDET 442
A+L P +FI P ++ E ++ + + ++ YF + + ++E
Sbjct: 429 AQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEI 488
Query: 443 LKKLQEAFDQACSSPQWVP 461
K+++ + WVP
Sbjct: 489 YNKIKQIIEDQSGHYIWVP 507
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 156 bits (395), Expect = 3e-38
Identities = 114/426 (26%), Positives = 198/426 (46%), Gaps = 66/426 (15%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
V+ IL GG G L GD+IL +NG ++ S +Q A+K +++ + P
Sbjct: 551 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDY 610
Query: 154 SRLPA--------------------------LQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
+R A +++RA FDYD KD+ +P + GL F
Sbjct: 611 ARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFK 668
Query: 188 TGDIIQIINKDDSNWWQGR---VEGSSKESAGLIPSPELQEWRVASMAQSA-----PSEA 239
GDI+ +IN D WWQ R +EG S+E G+IPS E + + ++ P
Sbjct: 669 YGDILHVINASDDEWWQARRVMLEGDSEE-MGVIPSKRRVERKERARLKTVKFNAKPGVI 727
Query: 240 PSCSPFGKKKK-----------YKDKYLAKHSSIFDQLD----VVSYEEVVRLPAFKRKT 284
S F K+K YK+K ++ + + ++SYE V R +
Sbjct: 728 DSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRP 787
Query: 285 LVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHF-ISTEEMTRNI 343
++++G + I + L+S+ P+KF VP+TTRP R E DG++YHF IS E+M ++I
Sbjct: 788 VIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDI 844
Query: 344 SANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPT 403
++F+E G Y N++GT ++V + ++ K ILD+ +K ++ A+L P +FI P
Sbjct: 845 QEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR 904
Query: 404 DQGTQTEALQQLQKDSE--------AIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACS 455
E ++L ++ + ++ YF + + +++ + + ++
Sbjct: 905 SLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSG 964
Query: 456 SPQWVP 461
W+P
Sbjct: 965 PFIWIP 970
Score = 35.4 bits (80), Expect = 0.11
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 12/121 (9%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR 155
+ +I+ GG G L V D IL +N +V+ S + +A+KE ++ L V + R
Sbjct: 234 ITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV----RRR 289
Query: 156 LPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESA 215
P L+ + + P K G A G Q I D+S + ++G + +
Sbjct: 290 RPILETVVEIKLFKGP--------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKD 341
Query: 216 G 216
G
Sbjct: 342 G 342
Score = 35.4 bits (80), Expect = 0.11
Identities = 17/56 (30%), Positives = 30/56 (53%)
Query: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
S V +I+ GG + G L VGD +L +N ++ + ++ +K T ++ LKV
Sbjct: 326 SIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 156 bits (395), Expect = 3e-38
Identities = 114/426 (26%), Positives = 198/426 (46%), Gaps = 66/426 (15%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
V+ IL GG G L GD+IL +NG ++ S +Q A+K +++ + P
Sbjct: 446 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDY 505
Query: 154 SRLPA--------------------------LQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
+R A +++RA FDYD KD+ +P + GL F
Sbjct: 506 ARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFK 563
Query: 188 TGDIIQIINKDDSNWWQGR---VEGSSKESAGLIPSPELQEWRVASMAQSA-----PSEA 239
GDI+ +IN D WWQ R +EG S+E G+IPS E + + ++ P
Sbjct: 564 YGDILHVINASDDEWWQARRVMLEGDSEE-MGVIPSKRRVERKERARLKTVKFNAKPGVI 622
Query: 240 PSCSPFGKKKK-----------YKDKYLAKHSSIFDQLD----VVSYEEVVRLPAFKRKT 284
S F K+K YK+K ++ + + ++SYE V R +
Sbjct: 623 DSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRP 682
Query: 285 LVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHF-ISTEEMTRNI 343
++++G + I + L+S+ P+KF VP+TTRP R E DG++YHF IS E+M ++I
Sbjct: 683 VIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDI 739
Query: 344 SANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPT 403
++F+E G Y N++GT ++V + ++ K ILD+ +K ++ A+L P +FI P
Sbjct: 740 QEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR 799
Query: 404 DQGTQTEALQQLQKDSE--------AIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACS 455
E ++L ++ + ++ YF + + +++ + + ++
Sbjct: 800 SLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSG 859
Query: 456 SPQWVP 461
W+P
Sbjct: 860 PFIWIP 865
Score = 35.4 bits (80), Expect = 0.11
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 12/121 (9%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR 155
+ +I+ GG G L V D IL +N +V+ S + +A+KE ++ L V + R
Sbjct: 129 ITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV----RRR 184
Query: 156 LPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESA 215
P L+ + + P K G A G Q I D+S + ++G + +
Sbjct: 185 RPILETVVEIKLFKGP--------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKD 236
Query: 216 G 216
G
Sbjct: 237 G 237
Score = 35.4 bits (80), Expect = 0.11
Identities = 17/56 (30%), Positives = 30/56 (53%)
Query: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
S V +I+ GG + G L VGD +L +N ++ + ++ +K T ++ LKV
Sbjct: 221 SIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 153 bits (386), Expect = 4e-37
Identities = 112/413 (27%), Positives = 191/413 (46%), Gaps = 58/413 (14%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
V+ IL GG G L GD+IL +NG ++ S +Q A+K +++ + P
Sbjct: 343 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDY 402
Query: 154 SRLPA--------------------------LQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
+R A +++RA FDYD KD+ +P + GL F
Sbjct: 403 ARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFK 460
Query: 188 TGDIIQIINKDDSNWWQGR---VEGSSKESAGLIPSPELQEWR-------VASMAQSAPS 237
GDI+ +IN D WWQ R +EG S+E G+IPS E + V A+
Sbjct: 461 YGDILHVINASDDEWWQARRVMLEGDSEE-MGVIPSKRRVERKERARLKTVKFNAKPGVI 519
Query: 238 EAPSCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSH 297
++ P Y K L + ++SYE V R + ++++G +
Sbjct: 520 DSKGDIPGLGDDGYGTKTLRGQEDL-----ILSYEPVTRQEINYTRPVIILGPM---KDR 571
Query: 298 IKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHF-ISTEEMTRNISANEFLEFGSYQG 356
I + L+S+ P+KF VP+TTRP R E DG++YHF IS E+M ++I ++F+E G Y
Sbjct: 572 INDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYND 631
Query: 357 NMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQ 416
N++GT ++V + ++ K ILD+ +K ++ A+L P +FI P E ++L
Sbjct: 632 NLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLT 691
Query: 417 KDSE--------AIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVP 461
++ + ++ YF + + +++ + + ++ W+P
Sbjct: 692 EEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 744
Score = 35.4 bits (80), Expect = 0.11
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 12/121 (9%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR 155
+ +I+ GG G L V D IL +N +V+ S + +A+KE ++ L V + R
Sbjct: 78 ITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV----RRR 133
Query: 156 LPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESA 215
P L+ + + P K G A G Q I D+S + ++G + +
Sbjct: 134 RPILETVVEIKLFKGP--------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKD 185
Query: 216 G 216
G
Sbjct: 186 G 186
Score = 35.4 bits (80), Expect = 0.11
Identities = 17/56 (30%), Positives = 30/56 (53%)
Query: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
S V +I+ GG + G L VGD +L +N ++ + ++ +K T ++ LKV
Sbjct: 170 SIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 150 bits (378), Expect = 3e-36
Identities = 107/408 (26%), Positives = 186/408 (45%), Gaps = 68/408 (16%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
++ IL GG G L GD+IL +NG ++ N S +Q A+K +++ + P +
Sbjct: 381 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEY 440
Query: 154 SRL--------------------------PALQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
SR P ++RA FDYD KD L F
Sbjct: 441 SRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD--CGFLSQALSFR 498
Query: 188 TGDIIQIINKDDSNWWQGRVEGSSKES--AGLIPSP---ELQEWRVASMAQSAPSEAPSC 242
GD++ +I+ D WWQ R S E+ G IPS E +EW
Sbjct: 499 FGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREW---------------- 542
Query: 243 SPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNAL 302
+ K KD + + S + V+SYE V ++ + ++++G + + + L
Sbjct: 543 ----SRLKAKD-WGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPT---KDRANDDL 594
Query: 303 LSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFIST-EEMTRNISANEFLEFGSYQGNMFGT 361
LS+ P+KF VP+TTRP R+ E DG++YHF+S+ E+M ++I A++F+E G Y +++GT
Sbjct: 595 LSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGT 654
Query: 362 KFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKD--- 418
++V ++ +Q K ILD+ ++ ++ A L P +FI P E +++ ++
Sbjct: 655 SVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQAR 714
Query: 419 -----SEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVP 461
+ + ++ F + + +E K++ + WVP
Sbjct: 715 KAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 762
Score = 40.8 bits (94), Expect = 0.003
Identities = 19/56 (33%), Positives = 31/56 (55%)
Query: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
S V +I+ GG H+ G L +GD+IL +N + + + A+K T ++ LKV
Sbjct: 231 SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286
Score = 39.7 bits (91), Expect = 0.006
Identities = 46/195 (23%), Positives = 79/195 (40%), Gaps = 27/195 (13%)
Query: 33 PEAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEEP----MGITLK- 87
P + + N+ + T+ APG QV G E +++E++T E +G ++
Sbjct: 69 PAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGE----MEYEEITLERGNSGLGFSIAG 124
Query: 88 ------LNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETK 141
+ + S + +I+ GG + G L V D IL +N +V + +A+KE
Sbjct: 125 GTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAG 184
Query: 142 GMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSN 201
++ L V+ R P + M + P K G A G Q I D+S
Sbjct: 185 SIVRLYVM----RRKPPAEKVMEIKLIKGP--------KGLGFSIAGGVGNQHIPGDNSI 232
Query: 202 WWQGRVEGSSKESAG 216
+ +EG + G
Sbjct: 233 YVTKIIEGGAAHKDG 247
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 150 bits (378), Expect = 3e-36
Identities = 107/408 (26%), Positives = 186/408 (45%), Gaps = 68/408 (16%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
++ IL GG G L GD+IL +NG ++ N S +Q A+K +++ + P +
Sbjct: 335 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEY 394
Query: 154 SRL--------------------------PALQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
SR P ++RA FDYD KD L F
Sbjct: 395 SRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD--CGFLSQALSFR 452
Query: 188 TGDIIQIINKDDSNWWQGRVEGSSKES--AGLIPSP---ELQEWRVASMAQSAPSEAPSC 242
GD++ +I+ D WWQ R S E+ G IPS E +EW
Sbjct: 453 FGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREW---------------- 496
Query: 243 SPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNAL 302
+ K KD + + S + V+SYE V ++ + ++++G + + + L
Sbjct: 497 ----SRLKAKD-WGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPT---KDRANDDL 548
Query: 303 LSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFIST-EEMTRNISANEFLEFGSYQGNMFGT 361
LS+ P+KF VP+TTRP R+ E DG++YHF+S+ E+M ++I A++F+E G Y +++GT
Sbjct: 549 LSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGT 608
Query: 362 KFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKD--- 418
++V ++ +Q K ILD+ ++ ++ A L P +FI P E +++ ++
Sbjct: 609 SVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQAR 668
Query: 419 -----SEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVP 461
+ + ++ F + + +E K++ + WVP
Sbjct: 669 KAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 716
Score = 40.8 bits (94), Expect = 0.003
Identities = 19/56 (33%), Positives = 31/56 (55%)
Query: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
S V +I+ GG H+ G L +GD+IL +N + + + A+K T ++ LKV
Sbjct: 185 SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
Score = 34.7 bits (78), Expect = 0.19
Identities = 32/129 (24%), Positives = 52/129 (40%), Gaps = 12/129 (9%)
Query: 88 LNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLK 147
+ + S + +I+ GG + G L V D IL +N +V + +A+KE ++ L
Sbjct: 85 IGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLY 144
Query: 148 VIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRV 207
V+ R P + M + P K G A G Q I D+S + +
Sbjct: 145 VM----RRKPPAEKVMEIKLIKGP--------KGLGFSIAGGVGNQHIPGDNSIYVTKII 192
Query: 208 EGSSKESAG 216
EG + G
Sbjct: 193 EGGAAHKDG 201
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 149 bits (377), Expect = 4e-36
Identities = 118/468 (25%), Positives = 212/468 (45%), Gaps = 70/468 (14%)
Query: 55 PGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLN------------EKQSCTVARILHG 102
P SPA+ V K ++ +++T EP + L + + ++ IL G
Sbjct: 441 PASPARYS--PVSKA-VLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAG 497
Query: 103 GMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQSRLPA-- 158
G G L GD I+ +N ++ S +Q A+K +++ + P + SR A
Sbjct: 498 GPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKI 557
Query: 159 ------------------------LQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQI 194
+++RA FDYD KD+ +P + GL F GDI+ +
Sbjct: 558 HDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--GLNFKFGDILHV 615
Query: 195 INKDDSNWWQGR---VEGSSKESAGLIPSPELQEWRVASMAQSA--------PSEAPSCS 243
IN D WWQ R +G S E G+IPS E + + ++ E P
Sbjct: 616 INASDDEWWQARQVTPDGESDE-VGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDM 674
Query: 244 PFGKKKKYKDKYLAKHSSIFDQLD-VVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNAL 302
K SS Q + V+SYE V + + ++++G + I + L
Sbjct: 675 GSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPM---KDRINDDL 731
Query: 303 LSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFI-STEEMTRNISANEFLEFGSYQGNMFGT 361
+S+ P+KF VP+TTRP R E DG++YHF+ S E+M ++I ++F+E G Y +++GT
Sbjct: 732 ISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGT 791
Query: 362 KFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKD--- 418
++V ++ ++ K ILD+ +K ++ A+L P +FI P E ++L ++
Sbjct: 792 SVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQAR 851
Query: 419 -----SEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVP 461
+ + ++ +F + + +++ ++++ ++ S WVP
Sbjct: 852 KTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVP 899
Score = 40.8 bits (94), Expect = 0.003
Identities = 18/56 (32%), Positives = 31/56 (55%)
Query: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
S V +I+ GG H+ G L +GD++L +N + + ++ A+K T + LKV
Sbjct: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
Score = 36.2 bits (82), Expect = 0.065
Identities = 32/129 (24%), Positives = 54/129 (41%), Gaps = 12/129 (9%)
Query: 88 LNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLK 147
+ + S + +I+ GG + G L V D IL +N +V + + + +A+KE ++ L
Sbjct: 247 IGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLY 306
Query: 148 VIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRV 207
V + R P + M + P K G A G Q I D+S + +
Sbjct: 307 V----KRRKPVSEKIMEIKLIKGP--------KGLGFSIAGGVGNQHIPGDNSIYVTKII 354
Query: 208 EGSSKESAG 216
EG + G
Sbjct: 355 EGGAAHKDG 363
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 147 bits (370), Expect = 3e-35
Identities = 73/218 (33%), Positives = 124/218 (56%), Gaps = 23/218 (10%)
Query: 271 YEEVVRL---PAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEED 327
YEEVVR P+ K + +VL+G SGVG + ++ L+ NP F VP+TTR + E +
Sbjct: 413 YEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMN 472
Query: 328 GKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKI 387
G+EYH++S E I ++ LE+G Y+G+++GT + V + + KI ++D+EPQ ++
Sbjct: 473 GREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQG 532
Query: 388 VRTAELSPFIVFIAPT--------------------DQGTQTEALQQLQKDSEAIRSQYA 427
VRT EL P+++FI P+ D + E LQ+++ ++ + +Q+
Sbjct: 533 VRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFG 592
Query: 428 HYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWV 465
+FD +VN+ + + +L A +A PQWVP +W+
Sbjct: 593 QFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWI 630
Score = 116 bits (290), Expect = 5e-26
Identities = 60/166 (36%), Positives = 98/166 (59%), Gaps = 2/166 (1%)
Query: 79 EEPMGITLKLNEKQS-CTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAM 137
++P+G T+K +E VARI+HGG+ R G L+ GD+++E+NG +V +Q+ +
Sbjct: 161 QQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHIL 220
Query: 138 KETKGMISLKVIPNQQSRLPALQM-FMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIIN 196
++G I KV+P + + QM ++RA +Y P++D IPC +AGL F GDI+QI++
Sbjct: 221 AMSRGTIMFKVVPVSDPPVNSQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVD 280
Query: 197 KDDSNWWQGRVEGSSKESAGLIPSPELQEWRVASMAQSAPSEAPSC 242
++D+ WWQ R AGL+PS L + + S P + +C
Sbjct: 281 QNDALWWQARKISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTC 326
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 146 bits (368), Expect = 4e-35
Identities = 123/490 (25%), Positives = 223/490 (45%), Gaps = 92/490 (18%)
Query: 55 PGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLN------------EKQSCTVARILHG 102
P SPA+ V K ++ +++T EP + L + + ++ IL G
Sbjct: 441 PASPARYS--PVSKA-VLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAG 497
Query: 103 GMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQSRLPAL- 159
G G L GD I+ +N ++ S +Q A+K +++ + P + SR A
Sbjct: 498 GPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKI 557
Query: 160 -------------------------QMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQI 194
+++RA FDYD KD+ +P + GL F GDI+ +
Sbjct: 558 HDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--GLNFKFGDILHV 615
Query: 195 INKDDSNWWQGRV---EGSSKESAGLIPSPELQEW----RVASMAQSAPSEAPSCSPFGK 247
IN D WWQ R +G S E G+IPS E R+ ++ ++ + S K
Sbjct: 616 INASDDEWWQARQVTPDGESDE-VGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDK 674
Query: 248 KKK---------YKDKYLAKH-----------------SSIFDQLD-VVSYEEVVRLPAF 280
+KK YK+K ++ SS Q + V+SYE V +
Sbjct: 675 RKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVN 734
Query: 281 KRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFI-STEEM 339
+ ++++G + I + L+S+ P+KF VP+TTRP R E DG++YHF+ S E+M
Sbjct: 735 YTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQM 791
Query: 340 TRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVF 399
++I ++F+E G Y +++GT ++V ++ ++ K ILD+ +K ++ A+L P +F
Sbjct: 792 EKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIF 851
Query: 400 IAPTDQGTQTEALQQLQKD--------SEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFD 451
I P E ++L ++ + + ++ +F + + +++ ++++ +
Sbjct: 852 IKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIE 911
Query: 452 QACSSPQWVP 461
+ S WVP
Sbjct: 912 EQSGSYIWVP 921
Score = 40.8 bits (94), Expect = 0.003
Identities = 18/56 (32%), Positives = 31/56 (55%)
Query: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
S V +I+ GG H+ G L +GD++L +N + + ++ A+K T + LKV
Sbjct: 347 SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
Score = 36.2 bits (82), Expect = 0.065
Identities = 32/129 (24%), Positives = 54/129 (41%), Gaps = 12/129 (9%)
Query: 88 LNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLK 147
+ + S + +I+ GG + G L V D IL +N +V + + + +A+KE ++ L
Sbjct: 247 IGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLY 306
Query: 148 VIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRV 207
V + R P + M + P K G A G Q I D+S + +
Sbjct: 307 V----KRRKPVSEKIMEIKLIKGP--------KGLGFSIAGGVGNQHIPGDNSIYVTKII 354
Query: 208 EGSSKESAG 216
EG + G
Sbjct: 355 EGGAAHKDG 363
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 141 bits (355), Expect = 1e-33
Identities = 92/320 (28%), Positives = 159/320 (49%), Gaps = 30/320 (9%)
Query: 161 MFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGR---VEGSSKESAGL 217
+++RA FDYD KD+ +P + GL F GDI+ +IN D WWQ R +EG S+E G+
Sbjct: 21 LYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEM-GV 77
Query: 218 IPSPELQEWR-------VASMAQSAPSEAPSCSPFGKKKKYKDKYLAKHSSIFDQLDVVS 270
IPS E + V A+ ++ P Y K L + ++S
Sbjct: 78 IPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDL-----ILS 132
Query: 271 YEEVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKE 330
YE V R + ++++G + I + L+S+ P+KF VP+TTRP R E DG++
Sbjct: 133 YEPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRD 189
Query: 331 YHF-ISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVR 389
YHF IS E+M ++I ++F+E G Y N++GT ++V + ++ K ILD+ +K ++
Sbjct: 190 YHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQ 249
Query: 390 TAELSPFIVFIAPTDQGTQTEALQQLQKDSE--------AIRSQYAHYFDLSLVNNGVDE 441
A+L P +FI P E ++L ++ + ++ YF + + +++
Sbjct: 250 VAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLED 309
Query: 442 TLKKLQEAFDQACSSPQWVP 461
+ + ++ W+P
Sbjct: 310 IYNQCKLVIEEQSGPFIWIP 329
>gi|226874833 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 107 bits (266), Expect = 3e-23
Identities = 58/191 (30%), Positives = 103/191 (53%), Gaps = 17/191 (8%)
Query: 283 KTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRN 342
+ +VL G SG G+S + LL ++ F + V +TTR PR EE+GK+Y+F++ E M R+
Sbjct: 5 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
Query: 343 ISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP 402
I+A +F+E + GN++GT V + N+I +LD++ Q ++ ++ +L P + + P
Sbjct: 65 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
Query: 403 ----------TDQGTQTE-----ALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQ 447
+ T+TE L Q D E+ S+ FD+ ++N+ +D+ +L+
Sbjct: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMES--SKEPGLFDVVIINDSLDQAYAELK 182
Query: 448 EAFDQACSSPQ 458
EA + Q
Sbjct: 183 EALSEEIKKAQ 193
>gi|226874831 guanylate kinase 1 isoform a [Homo sapiens]
Length = 218
Score = 107 bits (266), Expect = 3e-23
Identities = 58/191 (30%), Positives = 103/191 (53%), Gaps = 17/191 (8%)
Query: 283 KTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRN 342
+ +VL G SG G+S + LL ++ F + V +TTR PR EE+GK+Y+F++ E M R+
Sbjct: 26 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 85
Query: 343 ISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP 402
I+A +F+E + GN++GT V + N+I +LD++ Q ++ ++ +L P + + P
Sbjct: 86 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 145
Query: 403 ----------TDQGTQTE-----ALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQ 447
+ T+TE L Q D E+ S+ FD+ ++N+ +D+ +L+
Sbjct: 146 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMES--SKEPGLFDVVIINDSLDQAYAELK 203
Query: 448 EAFDQACSSPQ 458
EA + Q
Sbjct: 204 EALSEEIKKAQ 214
>gi|4504221 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 107 bits (266), Expect = 3e-23
Identities = 58/191 (30%), Positives = 103/191 (53%), Gaps = 17/191 (8%)
Query: 283 KTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRN 342
+ +VL G SG G+S + LL ++ F + V +TTR PR EE+GK+Y+F++ E M R+
Sbjct: 5 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
Query: 343 ISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP 402
I+A +F+E + GN++GT V + N+I +LD++ Q ++ ++ +L P + + P
Sbjct: 65 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
Query: 403 ----------TDQGTQTE-----ALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQ 447
+ T+TE L Q D E+ S+ FD+ ++N+ +D+ +L+
Sbjct: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMES--SKEPGLFDVVIINDSLDQAYAELK 182
Query: 448 EAFDQACSSPQ 458
EA + Q
Sbjct: 183 EALSEEIKKAQ 193
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 57.4 bits (137), Expect = 3e-08
Identities = 40/178 (22%), Positives = 76/178 (42%), Gaps = 14/178 (7%)
Query: 285 LVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNIS 344
L+L G G+ + + L Q F Y +TTRPP E D +YHFIS + ++
Sbjct: 417 LILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVN 476
Query: 345 ANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTD 404
+F+ SY + +G +TV I + + + +E + ++ ++ + P + + P +
Sbjct: 477 MGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMN 536
Query: 405 QGTQTEALQQLQKDSEA--------------IRSQYAHYFDLSLVNNGVDETLKKLQE 448
+ L++ S A I + YFD + + +D +KL +
Sbjct: 537 KEKYEGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQ 594
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 57.0 bits (136), Expect = 4e-08
Identities = 90/463 (19%), Positives = 181/463 (39%), Gaps = 82/463 (17%)
Query: 53 PAPGSPAQVKGQEVRKVR--LIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGS 110
PA S +++ G +K + F K ++ +G+ L VA +
Sbjct: 1481 PAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDG 1540
Query: 111 LHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVI--PNQQSR---LPALQMFMRA 165
L GD ILE +V N +V+++ M + + + LKV P + ++ LP ++RA
Sbjct: 1541 LVPGDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRA 1600
Query: 166 QFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDS-------NWWQGRV-EGSSKESAGL 217
+D + E L F DI+ + DD+ +W ++ E + K G
Sbjct: 1601 LYDR-------LADVEQELSFKKDDILYV---DDTLPQGTFGSWMAWQLDENAQKIQRGQ 1650
Query: 218 IPSP-----------ELQEWRVASMAQSAPSEAPSCSPFGKKKKYK-------------D 253
IPS + E + + A S A S F +K K+K D
Sbjct: 1651 IPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALD 1710
Query: 254 KYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYP 313
+ + +F+ ++Y+ V ++ + ++++G +K L+++ P KF
Sbjct: 1711 AFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPL---LDVVKEMLVNEAPGKFC-- 1765
Query: 314 VPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQN 373
R P E S + + R + F+++ G+ T ++ +I ++N
Sbjct: 1766 -----RCPL-------EVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKN 1813
Query: 374 KIAILDIEPQTLKIVRTAELSPFIVF---------------IAPTDQGTQTEALQQLQKD 418
+ +LDI P ++ + + P ++F I D+ TQ + +Q +
Sbjct: 1814 RHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEA- 1872
Query: 419 SEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVP 461
++ + +Y+ YF + + ++ +Q + W+P
Sbjct: 1873 AQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIP 1915
Score = 39.7 bits (91), Expect = 0.006
Identities = 22/67 (32%), Positives = 40/67 (59%), Gaps = 2/67 (2%)
Query: 66 VRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNV 125
V + R ++ +K +E P+GI++ EK V+++ G + H+ G L GD++LE NG N+
Sbjct: 1345 VEEPRHVKVQKGSE-PLGISIVSGEKGGIYVSKVTVGSIAHQAG-LEYGDQLLEFNGINL 1402
Query: 126 TNHSVDQ 132
+ + Q
Sbjct: 1403 RSATEQQ 1409
Score = 37.7 bits (86), Expect = 0.022
Identities = 20/61 (32%), Positives = 34/61 (55%), Gaps = 3/61 (4%)
Query: 97 ARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMIS---LKVIPNQQ 153
A +L G ++GSL VGD I+ ING + N S+++ + ++ + ++ LKV P
Sbjct: 741 AAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSS 800
Query: 154 S 154
S
Sbjct: 801 S 801
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 53.5 bits (127), Expect = 4e-07
Identities = 84/417 (20%), Positives = 170/417 (40%), Gaps = 63/417 (15%)
Query: 69 VRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNH 128
++L++F K + +G+ L VA +L ++G L GD+IL +N + TN
Sbjct: 422 MKLVKFRK--GDSVGLRLAGGNDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNI 478
Query: 129 SVDQLQKAMKETKGMISLKVIPNQQSRLPAL--------QMFMRAQFDYDPKKDNLIPCK 180
++ + + + ++ ++ + ++R F+Y+ +
Sbjct: 479 IREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPY----- 533
Query: 181 EAGLKFATGDIIQII----NKDDSNWWQGRVEGSSKE-SAGLIPSPELQEWRVASMAQSA 235
GL F G++ +++ N +W R+ + KE G+IP+ E ++AS+ +
Sbjct: 534 --GLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAE-QLASVQYTL 590
Query: 236 PSEAPSCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGR 295
P A +++ +K + + D+ + + PA++R V++ +G R
Sbjct: 591 PKTAGGDR--ADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYER---VVLREAGFLR 645
Query: 296 SHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQ 355
P P+ R EE I+ +E + G+ Q
Sbjct: 646 -----------PVTIFGPIADVAREKLAREEPD-----------IYQIAKSEPRDAGTDQ 683
Query: 356 GNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP-TDQGTQT----- 409
+ + T+ QI Q+K A+LD+ P + + A+ P +VF+ P + QG +T
Sbjct: 684 RSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRL 743
Query: 410 -----EALQQLQKDSEAIRSQYAHYFDLSL-VNNGVDETLKKLQEAFDQACSSPQWV 460
++ ++L + S +R H F ++ +N+ D L+EA Q + WV
Sbjct: 744 CPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 34.7 bits (78), Expect = 0.19
Identities = 17/61 (27%), Positives = 33/61 (54%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR 155
V I + R G++ GD +L+INGT N S+ + ++ +KG + + V ++++
Sbjct: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERAT 267
Query: 156 L 156
L
Sbjct: 268 L 268
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 53.5 bits (127), Expect = 4e-07
Identities = 84/417 (20%), Positives = 170/417 (40%), Gaps = 63/417 (15%)
Query: 69 VRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNH 128
++L++F K + +G+ L VA +L ++G L GD+IL +N + TN
Sbjct: 422 MKLVKFRK--GDSVGLRLAGGNDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNI 478
Query: 129 SVDQLQKAMKETKGMISLKVIPNQQSRLPAL--------QMFMRAQFDYDPKKDNLIPCK 180
++ + + + ++ ++ + ++R F+Y+ +
Sbjct: 479 IREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPY----- 533
Query: 181 EAGLKFATGDIIQII----NKDDSNWWQGRVEGSSKE-SAGLIPSPELQEWRVASMAQSA 235
GL F G++ +++ N +W R+ + KE G+IP+ E ++AS+ +
Sbjct: 534 --GLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAE-QLASVQYTL 590
Query: 236 PSEAPSCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGR 295
P A +++ +K + + D+ + + PA++R V++ +G R
Sbjct: 591 PKTAGGDR--ADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYER---VVLREAGFLR 645
Query: 296 SHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQ 355
P P+ R EE I+ +E + G+ Q
Sbjct: 646 -----------PVTIFGPIADVAREKLAREEPD-----------IYQIAKSEPRDAGTDQ 683
Query: 356 GNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP-TDQGTQT----- 409
+ + T+ QI Q+K A+LD+ P + + A+ P +VF+ P + QG +T
Sbjct: 684 RSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRL 743
Query: 410 -----EALQQLQKDSEAIRSQYAHYFDLSL-VNNGVDETLKKLQEAFDQACSSPQWV 460
++ ++L + S +R H F ++ +N+ D L+EA Q + WV
Sbjct: 744 CPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 34.7 bits (78), Expect = 0.19
Identities = 17/61 (27%), Positives = 33/61 (54%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR 155
V I + R G++ GD +L+INGT N S+ + ++ +KG + + V ++++
Sbjct: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERAT 267
Query: 156 L 156
L
Sbjct: 268 L 268
>gi|122937249 glutamate receptor interacting protein 2 [Homo
sapiens]
Length = 1141
Score = 50.1 bits (118), Expect = 4e-06
Identities = 27/90 (30%), Positives = 48/90 (53%), Gaps = 3/90 (3%)
Query: 71 LIQFEKVTEEPMGITL---KLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTN 127
+++ K +GI+L L K T+ RI ++ R G+LH GD IL I+GT++ +
Sbjct: 345 MVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEH 404
Query: 128 HSVDQLQKAMKETKGMISLKVIPNQQSRLP 157
S+ + K + + L+++P QS+ P
Sbjct: 405 CSLLEATKLLASISEKVRLEILPVPQSQRP 434
Score = 36.6 bits (83), Expect = 0.050
Identities = 18/70 (25%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 81 PMGITLKLNEK--QSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMK 138
P+GIT+ E+ ++ + G+ R G++HVGD IL IN ++ + + ++
Sbjct: 763 PLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQ 822
Query: 139 ETKGMISLKV 148
++LK+
Sbjct: 823 VAGETVTLKI 832
Score = 35.4 bits (80), Expect = 0.11
Identities = 17/80 (21%), Positives = 41/80 (51%), Gaps = 3/80 (3%)
Query: 72 IQFEKVTEEPMGITLKLNEK---QSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNH 128
++ K +GIT+ + + ++ I G + HR G+L GD++L I+ + N
Sbjct: 656 VKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNC 715
Query: 129 SVDQLQKAMKETKGMISLKV 148
++ + +++ + ++ LK+
Sbjct: 716 PMEDAVQILRQCEDLVKLKI 735
Score = 34.7 bits (78), Expect = 0.19
Identities = 20/87 (22%), Positives = 43/87 (49%), Gaps = 2/87 (2%)
Query: 64 QEVRKVRLIQFEKVTEEPMGITLK--LNEKQSCTVARILHGGMIHRQGSLHVGDEILEIN 121
+E R + +++ K +G+T+ ++ V+ + GG+ R L++GD I +N
Sbjct: 138 EEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVN 197
Query: 122 GTNVTNHSVDQLQKAMKETKGMISLKV 148
G ++T D++ +K + L+V
Sbjct: 198 GIHLTRLRHDEIITLLKNVGERVVLEV 224
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 49.3 bits (116), Expect = 7e-06
Identities = 22/59 (37%), Positives = 34/59 (57%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQS 154
+ RI+ G R G L VGD IL +NG ++TN S + +KE ++L++IP +S
Sbjct: 1038 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDES 1096
Score = 46.2 bits (108), Expect = 6e-05
Identities = 20/50 (40%), Positives = 31/50 (62%)
Query: 312 YPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGT 361
+ VP TTR PR+ E G +Y+F++ +E + LE G+Y+GN +GT
Sbjct: 140 HAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGT 189
Score = 33.1 bits (74), Expect = 0.55
Identities = 15/32 (46%), Positives = 18/32 (56%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTN 127
V R+ G R G + +GDEILEING N
Sbjct: 1178 VLRLAEDGPAERCGKMRIGDEILEINGETTKN 1209
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 49.3 bits (116), Expect = 7e-06
Identities = 22/59 (37%), Positives = 34/59 (57%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQS 154
+ RI+ G R G L VGD IL +NG ++TN S + +KE ++L++IP +S
Sbjct: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDES 1067
Score = 46.2 bits (108), Expect = 6e-05
Identities = 20/50 (40%), Positives = 31/50 (62%)
Query: 312 YPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGT 361
+ VP TTR PR+ E G +Y+F++ +E + LE G+Y+GN +GT
Sbjct: 140 HAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGT 189
Score = 33.5 bits (75), Expect = 0.42
Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 19/83 (22%)
Query: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR 155
V R+ G R G + +GDEILEING N MK ++ ++++I N R
Sbjct: 1149 VLRLAEDGPAERCGKMRIGDEILEINGETTKN---------MKHSR---AIELIKNGGRR 1196
Query: 156 LPALQMFMR----AQFDYDPKKD 174
+++F++ + +YDP D
Sbjct: 1197 ---VRLFLKRGDGSVPEYDPSSD 1216
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,163,892
Number of Sequences: 37866
Number of extensions: 825467
Number of successful extensions: 2674
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 177
Number of HSP's successfully gapped in prelim test: 92
Number of HSP's that attempted gapping in prelim test: 2162
Number of HSP's gapped (non-prelim): 530
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.