Guide to the Human Genome
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Search of human proteins with 122937343

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937343 platelet endothelial aggregation receptor 1 [Homo
sapiens]
         (1037 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937343 platelet endothelial aggregation receptor 1 [Homo s...  2397   0.0  
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]               994   0.0  
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]              899   0.0  
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               616   e-176
gi|33598931 scavenger receptor class F, member 1 isoform 3 precu...   279   1e-74
gi|33598929 scavenger receptor class F, member 1 isoform 1 precu...   279   1e-74
gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo...   261   2e-69
gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo...   261   2e-69
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]           255   2e-67
gi|134244285 Notch homolog 3 [Homo sapiens]                           250   4e-66
gi|55770876 notch4 preproprotein [Homo sapiens]                       246   6e-65
gi|148833508 notch1 preproprotein [Homo sapiens]                      236   1e-61
gi|24041035 notch 2 preproprotein [Homo sapiens]                      215   2e-55
gi|153946395 tenascin C precursor [Homo sapiens]                      214   4e-55
gi|4557679 jagged 1 precursor [Homo sapiens]                          213   6e-55
gi|21704277 jagged 2 isoform a precursor [Homo sapiens]               209   8e-54
gi|21704279 jagged 2 isoform b precursor [Homo sapiens]               209   1e-53
gi|21264602 laminin alpha 5 [Homo sapiens]                            204   3e-52
gi|145309306 scavenger receptor class F, member 1 isoform 5 prec...   192   1e-48
gi|122937283 6720455I24Rik homolog [Homo sapiens]                     188   3e-47
gi|143770880 laminin, beta 4 [Homo sapiens]                           164   4e-40
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s...   163   9e-40
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa...   163   9e-40
gi|119703755 laminin, beta 2 precursor [Homo sapiens]                 162   2e-39
gi|38788416 laminin, alpha 1 precursor [Homo sapiens]                 155   2e-37
gi|9506545 delta-like 4 protein precursor [Homo sapiens]              149   2e-35
gi|110611156 laminin, gamma 3 precursor [Homo sapiens]                146   9e-35
gi|167614504 laminin, beta 1 precursor [Homo sapiens]                 143   7e-34
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]               143   1e-33
gi|219842266 usherin isoform B [Homo sapiens]                         142   2e-33

>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
            sapiens]
          Length = 1037

 Score = 2397 bits (6212), Expect = 0.0
 Identities = 1037/1037 (100%), Positives = 1037/1037 (100%)

Query: 1    MSPPLCPLLLLAVGLRLAGTLNPSDPNTCSFWESFTTTTKESHSRPFSLLPSEPCERPWE 60
            MSPPLCPLLLLAVGLRLAGTLNPSDPNTCSFWESFTTTTKESHSRPFSLLPSEPCERPWE
Sbjct: 1    MSPPLCPLLLLAVGLRLAGTLNPSDPNTCSFWESFTTTTKESHSRPFSLLPSEPCERPWE 60

Query: 61   GPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRCVAPNQC 120
            GPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRCVAPNQC
Sbjct: 61   GPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRCVAPNQC 120

Query: 121  QCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTP 180
            QCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTP
Sbjct: 121  QCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTP 180

Query: 181  GYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGV 240
            GYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGV
Sbjct: 181  GYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGV 240

Query: 241  FQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGD 300
            FQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGD
Sbjct: 241  FQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGD 300

Query: 301  RCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQ 360
            RCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQ
Sbjct: 301  RCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQ 360

Query: 361  APCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATS 420
            APCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATS
Sbjct: 361  APCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATS 420

Query: 421  GLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVP 480
            GLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVP
Sbjct: 421  GLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVP 480

Query: 481  CPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCD 540
            CPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCD
Sbjct: 481  CPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCD 540

Query: 541  HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPG 600
            HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPG
Sbjct: 541  HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPG 600

Query: 601  FRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGEN 660
            FRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGEN
Sbjct: 601  FRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGEN 660

Query: 661  CAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPET 720
            CAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPET
Sbjct: 661  CAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPET 720

Query: 721  GACVCPPGHSGAPCRIGIQEPFTVMPTTPVAYNSLGAVIGIAVLGSLVVALVALFIGYRH 780
            GACVCPPGHSGAPCRIGIQEPFTVMPTTPVAYNSLGAVIGIAVLGSLVVALVALFIGYRH
Sbjct: 721  GACVCPPGHSGAPCRIGIQEPFTVMPTTPVAYNSLGAVIGIAVLGSLVVALVALFIGYRH 780

Query: 781  WQKGKEHHHLAVAYSSGRLDGSEYVMPDVPPSYSHYYSNPSYHTLSQCSPNPPPPNKVPG 840
            WQKGKEHHHLAVAYSSGRLDGSEYVMPDVPPSYSHYYSNPSYHTLSQCSPNPPPPNKVPG
Sbjct: 781  WQKGKEHHHLAVAYSSGRLDGSEYVMPDVPPSYSHYYSNPSYHTLSQCSPNPPPPNKVPG 840

Query: 841  PLFASLQNPERPGGAQGHDNHTTLPADWKHRREPPPGPLDRGSSRLDRSYSYSYSNGPGP 900
            PLFASLQNPERPGGAQGHDNHTTLPADWKHRREPPPGPLDRGSSRLDRSYSYSYSNGPGP
Sbjct: 841  PLFASLQNPERPGGAQGHDNHTTLPADWKHRREPPPGPLDRGSSRLDRSYSYSYSNGPGP 900

Query: 901  FYNKGLISEEELGASVASLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQ 960
            FYNKGLISEEELGASVASLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQ
Sbjct: 901  FYNKGLISEEELGASVASLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQ 960

Query: 961  FWDSQRRRQPQPQRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYD 1020
            FWDSQRRRQPQPQRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYD
Sbjct: 961  FWDSQRRRQPQPQRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYD 1020

Query: 1021 LPPVRHPPSPPLRRQDR 1037
            LPPVRHPPSPPLRRQDR
Sbjct: 1021 LPPVRHPPSPPLRRQDR 1037


>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
          Length = 1140

 Score =  994 bits (2570), Expect = 0.0
 Identities = 496/1143 (43%), Positives = 600/1143 (52%), Gaps = 153/1143 (13%)

Query: 9    LLLAVGLRLAGTLNPSDPNTCSFWESFTTTTKESHSRPFSLLPSEPCER--PWEGPHTCP 66
            LLL   +  A  LN  DPN CS WES++ T +ES+  PF  +    C     W     C 
Sbjct: 14   LLLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNW---FKCT 70

Query: 67   QPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGW 126
            +  V YRT YR   KT +R++ QCC GFYES   CVP CA +CVHGRC+APN CQC PGW
Sbjct: 71   RHRVSYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGW 130

Query: 127  RGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPA 186
             G +CSS C    WGP C   C C N + C+P +G C C +G +   C   C  G YG  
Sbjct: 131  GGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGND 190

Query: 187  CQFRCQC-HGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQ 245
            C  RCQC +GA CD  TG C CP   TG  C+  C  G  G  C     CQNGGV     
Sbjct: 191  CHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVT 250

Query: 246  GSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREE 305
            G CSCP GWMGT+C  PCPEG  G NCSQEC+CHNGG CD  TGQC C+PGYTG+RC++E
Sbjct: 251  GECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDE 310

Query: 306  CPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTC 365
            CPVG +G  CAETC C    +C+  +GACLCE GF G+RC  RLCP+G YG+ C   C C
Sbjct: 311  CPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPC 370

Query: 366  DREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQC 425
              E++ SCHPM+GEC+C PGW+GL+CNE+C    +G  CQ+ C C +G  C + +G C C
Sbjct: 371  HLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTC 430

Query: 426  APGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGT 485
            APG+ G  C++ CP  TYG+NCS+RC C+N   CSP+DG C CK GW   +CS+ CP GT
Sbjct: 431  APGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGT 490

Query: 486  WGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGC 545
            WGF CN +CQC +   C+   G CTC PGW G  C+LPC  G +G  CA RCDC H+DGC
Sbjct: 491  WGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGC 550

Query: 546  DPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPS 605
             P  G C+C  GW G  C   C EG WG NCS  C CKNG +C P++G C CAPGFRG +
Sbjct: 551  HPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTT 610

Query: 606  CQRSCQPGRYGKRCVP-------------------------------------------- 621
            CQR C PG YG RC                                              
Sbjct: 611  CQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCA 670

Query: 622  --CKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGS 679
              C C N+  C+P + +C C  GW G DCSQPCPP HWG NC  TC CH+G  C   DG 
Sbjct: 671  GICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGE 730

Query: 680  CICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKC----------------HPE---- 719
            C C  GWTG +C + CPLG +G +C+  CQC  G  C                H E    
Sbjct: 731  CKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCP 790

Query: 720  -----------------------TGACVCPPGHSGAPCR------IGIQEPFTVMPTT-P 749
                                   TG C C PG  GA C       +G     +   T  P
Sbjct: 791  SGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALP 850

Query: 750  VAYNSLGAVIGIAVLGSLVVALVALFIGYRHWQKGKEHHHLAVAYSSG-RLDGSEYVMPD 808
                 +GA+ GI +L  +V+ L+ALFI YRH QKGKE    AV Y+   R+  ++Y +  
Sbjct: 851  ADSYQIGAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMRVVNADYTISG 910

Query: 809  VPP------SYSHYYSNPSYHTLSQCSPNPPPPNK--------VPGPLFASLQNPERPGG 854
              P      + SHY++NPSYHTL+QC+ +P   N+            LF +L+N      
Sbjct: 911  TLPHSNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFVNLKNVNPGKR 970

Query: 855  AQGHDNHTTLPADWKHRREPPPGPLDR-GSSRLDRSYSYSYSNGPGPFYNKGLISEEELG 913
                D   TLPADWKH      G L+  G+  LDRSY             K L    E  
Sbjct: 971  GPVGDCTGTLPADWKH-----GGYLNELGAFGLDRSYMGKSL--------KDLGKNSEYN 1017

Query: 914  ASVASL-SSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQFWDSQRRR---- 968
            +S  SL SSENPYATI+D P L     E  Y+EMK P     P        S  R     
Sbjct: 1018 SSNCSLSSSENPYATIKDPPVLIPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEV 1077

Query: 969  QPQPQRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYDLPPVRHPP 1028
            +P      G +     L        SQ P         YD PKNSHIP HYDL PVR   
Sbjct: 1078 EPTVSVVQGVFSNNGRL--------SQDP---------YDLPKNSHIPCHYDLLPVRDSS 1120

Query: 1029 SPP 1031
            S P
Sbjct: 1121 SSP 1123


>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
          Length = 1044

 Score =  899 bits (2323), Expect = 0.0
 Identities = 394/863 (45%), Positives = 486/863 (56%), Gaps = 101/863 (11%)

Query: 21  LNPSDPNTCSFWESFTTTTKESHSRPFSLLPSEPCER--PWEGPHTCPQPTVVYRTVYRQ 78
           LNP DPN CS WES+  T +ES++ PF  +    C     W     C +  + Y+T YR+
Sbjct: 20  LNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNW---FKCTRHRISYKTAYRR 76

Query: 79  VVKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPG 138
            ++T +R+R QCC G+YES  FC+PLC +ECVHGRCV+P+ C C PGW G DCSS C   
Sbjct: 77  GLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSD 136

Query: 139 MWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQC-HGAP 197
            WGP C   C C N + C+P +G C C +G +   C + C PG +G  CQ  CQC HGA 
Sbjct: 137 HWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGAS 196

Query: 198 CDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGT 257
           CDP+ G C C    TG  C+  C  G+ G  C     CQNGG      G C+CPPGW G 
Sbjct: 197 CDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGA 256

Query: 258 ICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAE 317
           +C+ PCP G  G NCSQ+C CH+GG CD  TGQC C  GY GDRC+EECP G FG  C++
Sbjct: 257 VCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQ 316

Query: 318 TCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMN 377
            CDC    +C P  GAC CE G+ G RC +RLCP+G +G  C  PC CD ++++SCHP+ 
Sbjct: 317 HCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVT 376

Query: 378 GECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASL 437
           G C+C PGW+G HCNESCP   +G GCQ  C C +G  C + +G C CAPG+ G  CA  
Sbjct: 377 GACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVS 436

Query: 438 CPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCA 497
           C   TYG NCS+ CSC N   CSP+DG C CKEGWQ  +C++PCP GTWG +CN SC CA
Sbjct: 437 CAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCA 496

Query: 498 HEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAG 557
           + A CSP  G+C+CTPGW G  C+LPCP G FG  C+  CDC H+DGCDPV G C C AG
Sbjct: 497 NGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAG 556

Query: 558 WMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGK 617
           W G RC  +CP G WG NCS +C+C+NGG+C PE+G+C CAPGFRGP CQR C PG YG 
Sbjct: 557 WTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGH 616

Query: 618 RCVP----------------------------------------------CKCANHSFCH 631
            C                                                C CAN+  C 
Sbjct: 617 GCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCS 676

Query: 632 PSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGW----- 686
           P +G+C C  GW G DCSQ CPPG WG  C   C CH+G +C  +DG+C C  GW     
Sbjct: 677 PIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFC 736

Query: 687 --------------------------------------TGHHCLEGCPLGTFGANCSQPC 708
                                                 TG HC + C  GTFG  C Q C
Sbjct: 737 TQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLC 796

Query: 709 QCGPGEKCHPETGACVCPPGHSGAPC---RIGIQE--PFT-VMPTTPVAYNSLGAVIGIA 762
           +C     C   TG C C PG  G  C    + ++E  P+T + P      +S+GAV GI 
Sbjct: 797 ECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAERHSVGAVTGIM 856

Query: 763 VLGSLVVALVALFIGYRHWQKGK 785
           +L  L+V L+ LF  +R  QK K
Sbjct: 857 LLLFLIVVLLGLFAWHRRRQKEK 879



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 50/128 (39%), Positives = 60/128 (46%), Gaps = 16/128 (12%)

Query: 904  KGLISEEELGASVASL-SSENPYATIRDLPSLPGGPRESSYMEMKGPPS-GSPPRQPPQF 961
            K  + E    +S  SL SSENPYATI+D P L     ESSY+EMK P   GSP    P  
Sbjct: 922  KDYMKESVCSSSTCSLNSSENPYATIKDPPILTCKLPESSYVEMKSPVHMGSPYTDVPSL 981

Query: 962  WDSQRRRQPQPQRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYDL 1021
              S +            YE    +   ++  G             YD P+NSHIPGHYDL
Sbjct: 982  STSNKN----------IYEVEPTVSVVQEGCGHNSSYIQNA----YDLPRNSHIPGHYDL 1027

Query: 1022 PPVRHPPS 1029
             PVR  P+
Sbjct: 1028 LPVRQSPA 1035


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  616 bits (1588), Expect = e-176
 Identities = 278/664 (41%), Positives = 334/664 (50%), Gaps = 22/664 (3%)

Query: 90   CCHGFYESR-------GFCVPLCAQECV---HGRC-VAPNQCQCVPGWRGDDCSSECAPG 138
            C  GF  SR       G+  P C   C     G C  A   C C PGW G  C   C  G
Sbjct: 804  CLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTG 863

Query: 139  MWGPQCDKPCSCG-NNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQC-HGA 196
             WGP C  PC+C   + SCD  SG+C C +G   P C Q C  G++GP C+ RCQC HGA
Sbjct: 864  HWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGA 923

Query: 197  PCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMG 256
             CD  +GAC CPA   G  C+ +C  G  G  C S  +C  G       GSC CP G  G
Sbjct: 924  ACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRG 983

Query: 257  TICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCA 316
              C+  CP   +G NCSQ C C NG  CD   GQC CAPG+ G  C + CP G +G +C 
Sbjct: 984  PRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCR 1043

Query: 317  ETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCP-DGFYGLSCQAPCTCDREHSLSCHP 375
             +C C     C P +G C C  G+ G  C     P D   G      C     +   C P
Sbjct: 1044 HSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCL----NGGLCDP 1099

Query: 376  MNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCA 435
              G C C  GW G  C   C +   G  C + C C  G  C   +G C+C PG+TG  C 
Sbjct: 1100 HTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCE 1159

Query: 436  SLCPPDTYGVNCSARCSC--ENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNAS 493
              CPP ++G +C+  C C  EN  AC P  G C C  G+   +C   CPPG +G  C   
Sbjct: 1160 QACPPGSFGEDCAQMCQCPGENP-ACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQL 1218

Query: 494  CQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQ 553
            C C +   C   TGAC C  G+ G  C L CP+G+FG  C   C C     CDPV G C 
Sbjct: 1219 CGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCL 1278

Query: 554  CQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPG 613
            C  G  G RC   CP+  +GV C +TC+C+NGG C   NG+C C  G+ G  C+ +C PG
Sbjct: 1279 CPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPG 1338

Query: 614  RYGKRC-VPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGT 672
            RYG  C + C C N+S C P+ GTC C  G+ G  C  PCPPG  G  C   C C HG  
Sbjct: 1339 RYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAP 1398

Query: 673  CHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGA 732
            C P  G C+CP G+ GH C  GC  G+FG  C Q C C  G  C P TG C+CPPG SGA
Sbjct: 1399 CDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGA 1458

Query: 733  PCRI 736
             C +
Sbjct: 1459 TCNL 1462



 Score =  607 bits (1564), Expect = e-173
 Identities = 266/650 (40%), Positives = 342/650 (52%), Gaps = 21/650 (3%)

Query: 103  PLCAQECVHGRCVAPN---------QCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNN 153
            P C++EC   +CV P+          C C  G+RG+ C +EC  G +GP C + C+C   
Sbjct: 648  PGCSEEC---QCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVG 704

Query: 154  SSCDPKSGVCS--CPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAER 211
             +CD  SG C   CP+G Q  +C Q C  G +G  C   C C GAPC   TG C CP  R
Sbjct: 705  VACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGR 764

Query: 212  TGPSCDVSCSQGTSGFFCPST-HSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGP 270
            TG  C+  C +G  G  C     +CQ+        G+C C PG++G+ C   CP G++GP
Sbjct: 765  TGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGP 824

Query: 271  NCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDC-APDARCFP 329
            +C   C C N G C   TG C CAPG+TG  C+  C  G +G DC+  C+C A    C  
Sbjct: 825  SCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDA 884

Query: 330  ANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGL 389
             +G CLCE G+ G RC ++ CP G +G  C+  C C  +H  +C  ++G C+C  GW G 
Sbjct: 885  ISGLCLCEAGYVGPRC-EQQCPQGHFGPGCEQRCQC--QHGAACDHVSGACTCPAGWRGT 941

Query: 390  HCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSA 449
             C  +CP    G  C+  C C  G  C A +G C C  G  GP CA  CP  TYG NCS 
Sbjct: 942  FCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQ 1001

Query: 450  RCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGAC 509
             C+C N  +C P+ G+C C  GW   +C   CP G +G +C  SC C +   C P +G C
Sbjct: 1002 ACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHC 1061

Query: 510  TCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPE 569
             C  GW G  C+  C       GC     C +   CDP  GRC C AGW G +C   C  
Sbjct: 1062 ACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLR 1121

Query: 570  GLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVP-CKCANHS 628
            G +G  C+  C+C  G  C    G C C PGF G  C+++C PG +G+ C   C+C   +
Sbjct: 1122 GWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGEN 1181

Query: 629  -FCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWT 687
              CHP+ GTC C AG+ GP C Q CPPG +G  C Q C C +GG+C    G+C CP G+ 
Sbjct: 1182 PACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFL 1241

Query: 688  GHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRIG 737
            G  C   CP G FG NC+  C CG G  C P TG C+CPPG +G  C  G
Sbjct: 1242 GTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERG 1291



 Score =  593 bits (1529), Expect = e-169
 Identities = 278/695 (40%), Positives = 334/695 (48%), Gaps = 60/695 (8%)

Query: 96   ESRGFCVPLCAQECVHGRC--VAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNN 153
            +S G    L   +C +G    +  + C C  GW G  C+  C P  +G  C   CSC N 
Sbjct: 514  DSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNG 573

Query: 154  SSCDPKSGVCSCPSGLQPPNCLQPCTPGYY------------------------------ 183
             +CD  +G C CP G+   NC   C  GYY                              
Sbjct: 574  GTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLY 633

Query: 184  -------------GPACQFRCQC---HGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGF 227
                         GP C   CQC   H   CD + G+C C A   G  C   C  G  G 
Sbjct: 634  GRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGP 693

Query: 228  FCPSTHSCQNGGVFQTPQGSCS--CPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCD 285
             C    +C  G    +  G C   CP G+ G  C   CP G  G NCS  C C  G  C 
Sbjct: 694  GCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSC-GGAPCH 752

Query: 286  RFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCD-CAPDARCFPANGACLCEHGFTGDR 344
              TGQCRC PG TG+ C  +CP GR+G  C E C  C   ARC P  GACLC  GF G R
Sbjct: 753  GVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSR 812

Query: 345  CTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGC 404
            C D +CP G+YG SCQ  C+C  +    CHP  G CSC PGW G  C  +C     GP C
Sbjct: 813  CQD-VCPAGWYGPSCQTRCSCANDG--HCHPATGHCSCAPGWTGFSCQRACDTGHWGPDC 869

Query: 405  QEHCLCLHG-GVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPID 463
               C C  G G C A SGLC C  GY GP C   CP   +G  C  RC C++  AC  + 
Sbjct: 870  SHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVS 929

Query: 464  GECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLP 523
            G C C  GW+   C   CP G +G  C ++C C   A C    G+C C  G  G  C   
Sbjct: 930  GACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAET 989

Query: 524  CPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCK 583
            CP   +G  C+  C C +   CDPVHG+C C  GWMG  C  +CP GL+G NC ++C C+
Sbjct: 990  CPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQ 1049

Query: 584  NGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPC-KCANHSFCHPSNGTCYCLAG 642
            NGGTC P +G+C C  G+ G +C++ C P      C     C N   C P  G C C AG
Sbjct: 1050 NGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAG 1109

Query: 643  WTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGA 702
            WTG  C  PC  G +GE CAQ C C  G  CH   G+C CP G+TG  C + CP G+FG 
Sbjct: 1110 WTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGE 1169

Query: 703  NCSQPCQCGPGEK--CHPETGACVCPPGHSGAPCR 735
            +C+Q CQC PGE   CHP TG C C  G+ G  C+
Sbjct: 1170 DCAQMCQC-PGENPACHPATGTCSCAAGYHGPSCQ 1203



 Score =  499 bits (1286), Expect = e-141
 Identities = 236/651 (36%), Positives = 292/651 (44%), Gaps = 97/651 (14%)

Query: 178  CTPGYYGPACQFRCQ-C-HGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSC 235
            C    +G  C   C  C +G  C      C CP   TG  C+ +C   T G  C  + SC
Sbjct: 511  CLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSC 570

Query: 236  QNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAP 295
            QNGG   +  G+C CPPG  GT C   CP+G++G +C ++C C N G C R  G C C P
Sbjct: 571  QNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDP 630

Query: 296  GYTGDRCREECPVGRFGQDCAETCDCAP--DARCFPANGACLCEHGFTGDRC-------- 345
            G  G  C   CP   FG  C+E C C       C   +G+C C+ GF G+RC        
Sbjct: 631  GLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGY 690

Query: 346  ------------------------------------TDRLCPDGFYGLSCQAPCTCDREH 369
                                                  + CP G +G++C + C+C    
Sbjct: 691  FGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCG--- 747

Query: 370  SLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHC-LCLHGGVCQATSGLCQCAPG 428
               CH + G+C C PG  G  C   CP+   G GCQE C  C H   C   +G C C PG
Sbjct: 748  GAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPG 807

Query: 429  YTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGF 488
            + G  C  +CP   YG +C  RCSC N   C P  G C C  GW   +C   C  G WG 
Sbjct: 808  FVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGP 867

Query: 489  SCNASCQC-AHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDP 547
             C+  C C A    C   +G C C  G+ G  C+  CP+G FG GC  RC C H   CD 
Sbjct: 868  DCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDH 927

Query: 548  VHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQ 607
            V G C C AGW G  C  +CP G +G++C + C C  G  C   NG+C+C  G RGP C 
Sbjct: 928  VSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCA 987

Query: 608  RSCQPGRYGKRC-VPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQ 666
             +C    YG  C   C C N + C P +G C+C  GW GP C Q CP G +G+NC  +C 
Sbjct: 988  ETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCL 1047

Query: 667  CHHGGT-------------------------------------------CHPQDGSCICP 683
            C +GGT                                           C P  G C+CP
Sbjct: 1048 CQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCP 1107

Query: 684  LGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPC 734
             GWTG  C   C  G FG  C+Q C C PG  CH  TGAC CPPG +G+ C
Sbjct: 1108 AGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGC 1158



 Score =  490 bits (1261), Expect = e-138
 Identities = 248/662 (37%), Positives = 308/662 (46%), Gaps = 42/662 (6%)

Query: 103  PLCAQECVHGRCVAPNQCQCVPGWR--GDDCS----SECAPGMWGPQCDKPCSCGNNSSC 156
            P C Q C +       +C C  G+R   D C      ECA    G  C+  C+  N +  
Sbjct: 380  PCCQQVCTNNP--GGYECGCYAGYRLSADGCGCEDVDECASSRGG--CEHHCT--NLAG- 432

Query: 157  DPKSGVCSCPSGLQPPNCLQPCTP------------GYYGPACQFRCQCHGAPC---DPQ 201
               S  CSC +G +     + C+P             +  P           P    D  
Sbjct: 433  ---SFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDD 489

Query: 202  TGACFCPAERTGPSCDVS---CSQGTSGFFCPST-HSCQNGGVFQTPQGSCSCPPGWMGT 257
             GA    AE  G         C   + G  C  T   C+NGG        C CP GW G 
Sbjct: 490  VGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGL 549

Query: 258  ICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAE 317
            IC+  CP    G NCS  C C NGG CD  TG CRC PG +G  C + CP G +G+ C +
Sbjct: 550  ICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRK 609

Query: 318  TCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMN 377
             C+CA   RC    GACLC+ G  G  C    CP   +G  C   C C + H+ SC   +
Sbjct: 610  KCNCANRGRCHRLYGACLCDPGLYGRFC-HLTCPPWAFGPGCSEECQCVQPHTQSCDKRD 668

Query: 378  GECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLC--QCAPGYTGPHCA 435
            G CSC  G+ G  C   C     GPGC + C C  G  C + SG C  +C  G+ G  C 
Sbjct: 669  GSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCG 728

Query: 436  SLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASC- 494
              CP  T+GVNCS+ CSC  A  C  + G+C C  G    +C   CP G WG  C   C 
Sbjct: 729  QECPVGTFGVNCSSSCSCGGA-PCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICP 787

Query: 495  QCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQC 554
             C H A C P+TGAC C PG+ G+ CQ  CP G +G  C +RC C +   C P  G C C
Sbjct: 788  ACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSC 847

Query: 555  QAGWMGARCHLSCPEGLWGVNCSNTCTCKNG-GTCLPENGNCVCAPGFRGPSCQRSCQPG 613
              GW G  C  +C  G WG +CS+ C C  G G+C   +G C+C  G+ GP C++ C  G
Sbjct: 848  APGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQG 907

Query: 614  RYGKRCVP-CKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGT 672
             +G  C   C+C + + C   +G C C AGW G  C   CP G +G +C   C C  G  
Sbjct: 908  HFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAA 967

Query: 673  CHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGA 732
            C   +GSC+CP G  G  C E CP  T+G NCSQ C C  G  C P  G C C PG  G 
Sbjct: 968  CDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGP 1027

Query: 733  PC 734
             C
Sbjct: 1028 SC 1029



 Score =  474 bits (1219), Expect = e-133
 Identities = 213/511 (41%), Positives = 258/511 (50%), Gaps = 9/511 (1%)

Query: 101  CVPLCAQECVHGRCVAP--NQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDP 158
            C   CA  C +G    P   QC C PGW G  C   C  G++G  C   C C N  +CDP
Sbjct: 999  CSQACA--CFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDP 1056

Query: 159  KSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQC-HGAPCDPQTGACFCPAERTGPSCD 217
             SG C+CP G     C + C P      C+    C +G  CDP TG C CPA  TG  C 
Sbjct: 1057 VSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQ 1116

Query: 218  VSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECR 277
              C +G  G  C    SC  G       G+C CPPG+ G+ C   CP G  G +C+Q C+
Sbjct: 1117 SPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQ 1176

Query: 278  CHNGG-LCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLC 336
            C      C   TG C CA GY G  C++ CP GR+G  C + C C     C  A GAC C
Sbjct: 1177 CPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRC 1236

Query: 337  EHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCP 396
              GF G  C +  CP G +G +C   C C +    +C P+ G C C PG AG+ C   CP
Sbjct: 1237 PTGFLGTDC-NLTCPQGRFGPNCTHVCGCGQ--GAACDPVTGTCLCPPGRAGVRCERGCP 1293

Query: 397  QDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENA 456
            Q+  G GC+  C C +GG+C A++G C C  G+TG HC   CPP  YG  C   CSC N 
Sbjct: 1294 QNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNN 1353

Query: 457  IACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWH 516
              C P  G C C  G+    C  PCPPG  G  C   C C H A C P +G C C  G+H
Sbjct: 1354 STCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFH 1413

Query: 517  GAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNC 576
            G  C+  C  G FGEGC  RCDCD    CDPV G C C  G  GA C+L C  G +G +C
Sbjct: 1414 GHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGPSC 1473

Query: 577  SNTCTCKNGGTCLPENGNCVCAPGFRGPSCQ 607
            +  C C  G  C P +G C C  G+ GP+C+
Sbjct: 1474 TLHCDCGGGADCDPVSGQCHCVDGYMGPTCR 1504



 Score =  347 bits (890), Expect = 3e-95
 Identities = 249/842 (29%), Positives = 315/842 (37%), Gaps = 151/842 (17%)

Query: 21  LNPSDPNTCSFWESFTTTTKESHSRPFS-LLPSEPCERPWEGPHTCPQPTVVYRTVYRQV 79
           L P  P+ C+  E      ++   +  S  +P       W+      +   VY   YRQV
Sbjct: 40  LQPGMPHVCAEQELTLVGRRQPCVQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQV 99

Query: 80  VKTDHRQRLQCCHGFYES---RGFCVPLC-AQECVHG-RCV--APNQCQCVPGWRGDDCS 132
             T+ R  L+CC G+ +     G     C A  C HG RCV  +   C C PG++G  C 
Sbjct: 100 YTTEARTVLRCCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQ 159

Query: 133 ---SECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQ----PPNCL--QPCTPGYY 183
               EC     G        C +     P S +C C  G +       CL    C  G  
Sbjct: 160 YDVDECRTHNGG--------CQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNG 211

Query: 184 GPACQF----------RCQCHG--------------APCDPQTGACF--CPAERTGPSCD 217
           G  CQ           RCQC                +PC  + G+C   C   R    C+
Sbjct: 212 G--CQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCE 269

Query: 218 --VSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQ- 274
             V       G  C     C   G+ Q   G C    G    +C      G  G  C + 
Sbjct: 270 CHVGYQLAADGKACEDVDECA-AGLAQCAHG-CLNTQGSFKCVCHAGYELGADGRQCYRI 327

Query: 275 ------ECRCHNGGL---CDRFTGQ--CRCAPGYTGDR----------------CREECP 307
                  C  +NGG    C   +    C C  GY  D                 C++ C 
Sbjct: 328 EMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCT 387

Query: 308 VGRFGQDC---------AETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLS 358
               G +C         A+ C C     C  + G C  EH      CT+     G +  S
Sbjct: 388 NNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGC--EH-----HCTNLA---GSFQCS 437

Query: 359 CQAPCTCDREHSLSCHPMNGECSCLPGW-------------------------AGLHCNE 393
           C+A      E    C P+      L G                           G    E
Sbjct: 438 CEAGYRL-HEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEE 496

Query: 394 S-------------CPQDTHGPGCQEHCL-CLHGGVCQATSGLCQCAPGYTGPHCASLCP 439
           +             C  D+ G  C   C  C +GG C      C C  G+TG  C   CP
Sbjct: 497 AELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCP 556

Query: 440 PDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHE 499
           PDT+G NCS  CSC+N   C  + G C C  G    NC   CP G +G  C   C CA+ 
Sbjct: 557 PDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANR 616

Query: 500 AVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDC--DHSDGCDPVHGRCQCQAG 557
             C    GAC C PG +G  C L CP   FG GC+  C C   H+  CD   G C C+AG
Sbjct: 617 GRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAG 676

Query: 558 WMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNC--VCAPGFRGPSCQRSCQPGRY 615
           + G RC   C  G +G  C   CTC  G  C   +G C   C  GF+G  C + C  G +
Sbjct: 677 FRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTF 736

Query: 616 GKRC-VPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTC-QCHHGGTC 673
           G  C   C C   + CH   G C C  G TG DC   CP G WG  C + C  C H   C
Sbjct: 737 GVNCSSSCSCGG-APCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARC 795

Query: 674 HPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAP 733
            P+ G+C+C  G+ G  C + CP G +G +C   C C     CHP TG C C PG +G  
Sbjct: 796 DPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFS 855

Query: 734 CR 735
           C+
Sbjct: 856 CQ 857



 Score =  151 bits (382), Expect = 3e-36
 Identities = 149/566 (26%), Positives = 199/566 (35%), Gaps = 115/566 (20%)

Query: 250 CPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQ-CRCAPGYTGDRCR---EE 305
           C  GWM      P  EG     CS    C +GG C   + Q C C PG+ G RC+   +E
Sbjct: 110 CCRGWM----QQPDEEGCLSAECSASL-CFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDE 164

Query: 306 CPVGRFG--QDCAET-----CDCAPDARCFPANGACL-----------CEHG-----FTG 342
           C     G    C  T     C+C P  R    +  CL           C+H       T 
Sbjct: 165 CRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITR 224

Query: 343 DRCTDRLCPDGFY----GLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQD 398
            RC    C  GF     G  C     C   +    H     C  + G A   C+      
Sbjct: 225 HRCQ---CRPGFQLQEDGRHCVRRSPCANRNGSCMH----RCQVVRGLARCECHVGYQLA 277

Query: 399 THGPGCQE--HCL-----CLHGGVCQATSGLCQCAPGYT----GPHCASL-------CPP 440
             G  C++   C      C HG +    S  C C  GY     G  C  +       C  
Sbjct: 278 ADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEA 337

Query: 441 DTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEA 500
           +  G  CS  CS  +A    P+   C C  G++       C        C  S  C    
Sbjct: 338 NNGG--CSHGCSHTSA---GPL---CTCPRGYELDTDQRTCIDVD---DCADSPCCQQVC 386

Query: 501 VCSPQTGACTCTPGWH----GAHCQLPCPKGQFGEGC---------ASRCDCD-----HS 542
             +P    C C  G+     G  C+          GC         + +C C+     H 
Sbjct: 387 TNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHE 446

Query: 543 D--GCDPVHGRCQCQAG---WMGARCHLSCPEGLW-------GVNCSNTCTCKNGGTCLP 590
           D  GC P+        G   ++    H++  +           V          G   L 
Sbjct: 447 DRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLT 506

Query: 591 ENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQ 650
           E    VC     G  C  +C             C N   C      C C  GWTG  C++
Sbjct: 507 EK--FVCLDDSFGHDCSLTCDD-----------CRNGGTCLLGLDGCDCPEGWTGLICNE 553

Query: 651 PCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQC 710
            CPP  +G+NC+ +C C +GGTC    G+C CP G +G +C +GCP G +G +C + C C
Sbjct: 554 TCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNC 613

Query: 711 GPGEKCHPETGACVCPPGHSGAPCRI 736
               +CH   GAC+C PG  G  C +
Sbjct: 614 ANRGRCHRLYGACLCDPGLYGRFCHL 639



 Score =  120 bits (302), Expect = 5e-27
 Identities = 135/526 (25%), Positives = 169/526 (32%), Gaps = 117/526 (22%)

Query: 292 RCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGA-CLCEHGFTGDRCTDRLC 350
           RC  G+      E C       +C+ +  C    RC P +   C C  GF G RC   + 
Sbjct: 109 RCCRGWMQQPDEEGC----LSAECSASL-CFHGGRCVPGSAQPCHCPPGFQGPRCQYDVD 163

Query: 351 PDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNE-------SCPQDTHGPG 403
               +   CQ  C           P +  C C PG+  LH +        SC     G  
Sbjct: 164 ECRTHNGGCQHRCVNT--------PGSYLCECKPGFR-LHTDSRTCLAINSCALGNGG-- 212

Query: 404 CQEHCLCLHGGVCQATSGLCQCAPGYT----GPHCASLCPPDTYGVNCSARCSCENAIAC 459
           CQ HC+ L       T   CQC PG+     G HC    P      +C  RC     +A 
Sbjct: 213 CQHHCVQL-----TITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLA- 266

Query: 460 SPIDGECVCKEGWQRG-----------------NCSVPCPPGTWGFSCNASCQCAHEA-- 500
                 C C  G+Q                    C+  C      F C   C   +E   
Sbjct: 267 -----RCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKC--VCHAGYELGA 319

Query: 501 --------------VCSPQTGACT--CTPGWHGAHCQLPCPKGQFGEGCASRC----DCD 540
                          C    G C+  C+    G  C   CP+G   +     C    DC 
Sbjct: 320 DGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCT--CPRGYELDTDQRTCIDVDDCA 377

Query: 541 HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNG-GTCLPENGNCVCAP 599
            S  C  V   C    G     C+        G  C +   C +  G C     +C    
Sbjct: 378 DSPCCQQV---CTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGC---EHHCTNLA 431

Query: 600 GFRGPSCQRSCQPGRYGKRCVPCK------CANHSFCHPSNGTCYCLAGW--------TG 645
           G    SC+   +     + C P +           F  P                    G
Sbjct: 432 GSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVG 491

Query: 646 PDCSQP-------------CPPGHWGENCAQTCQ-CHHGGTCHPQDGSCICPLGWTGHHC 691
            D  +              C    +G +C+ TC  C +GGTC      C CP GWTG  C
Sbjct: 492 ADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLIC 551

Query: 692 LEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRIG 737
            E CP  TFG NCS  C C  G  C   TGAC CPPG SG  C  G
Sbjct: 552 NETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDG 597



 Score = 35.0 bits (79), Expect = 0.37
 Identities = 21/60 (35%), Positives = 25/60 (41%), Gaps = 6/60 (10%)

Query: 682 CPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGA-CVCPPGHSGAPCRIGIQE 740
           C  GW      EGC      A CS    C  G +C P +   C CPPG  G  C+  + E
Sbjct: 110 CCRGWMQQPDEEGC----LSAECSASL-CFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDE 164


>gi|33598931 scavenger receptor class F, member 1 isoform 3
           precursor [Homo sapiens]
          Length = 569

 Score =  279 bits (713), Expect = 1e-74
 Identities = 149/401 (37%), Positives = 183/401 (45%), Gaps = 50/401 (12%)

Query: 240 VFQTPQGSCSCPPGWM--GTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGY 297
           V  +P     C  GW      C++P  EG   P+      C    +C +  G CRC PG+
Sbjct: 31  VASSPSAELQCCAGWRQKDQECTIPICEG---PDA-----CQKDEVCVK-PGLCRCKPGF 81

Query: 298 TGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRL-------- 349
            G  C   CP   +G DC E+C C P  +C PA GAC C+    G RC            
Sbjct: 82  FGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRC 141

Query: 350 --------CPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCN-------ES 394
                   C  G++  +C+ PC C+   +  C    G C C PGW G  C+         
Sbjct: 142 DPATGVCHCEPGWWSSTCRRPCQCNTA-AARCEQATGACVCKPGWWGRRCSFRCNCHGSP 200

Query: 395 CPQDTH---------GPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGV 445
           C QD+          GP CQ+ C C+ G  C A SG C C PG+ G  C   CP  ++GV
Sbjct: 201 CEQDSGRCACRPGWWGPECQQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGV 259

Query: 446 NCSARCS-CENAIACSPIDGECV-CKEGWQRGNCSVPCPPGTWGFSCNASC-QCAHEAVC 502
            C+  C  C++   CSP  G C  C+ GW    C  PC PGT+G SC   C  C H   C
Sbjct: 260 QCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEAC 319

Query: 503 SPQTGACT-CTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGA 561
            P TG C  C PGW G  C+ PCP G FGE C S C       CD V G C C AG+ G 
Sbjct: 320 EPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGP 379

Query: 562 RCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFR 602
            C+ SCP G  G NCS  C C   G C P +G+C    G R
Sbjct: 380 SCNASCPAGFHGNNCSVPCECPE-GLCHPVSGSCQPGSGSR 419



 Score =  271 bits (692), Expect = 3e-72
 Identities = 139/395 (35%), Positives = 173/395 (43%), Gaps = 48/395 (12%)

Query: 368 EHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAP 427
           +H       + E  C  GW          Q+   P C+    C    VC    GLC+C P
Sbjct: 27  QHVCVASSPSAELQCCAGW------RQKDQECTIPICEGPDACQKDEVC-VKPGLCRCKP 79

Query: 428 GYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCP----- 482
           G+ G HC+S CP   +G +C   C C     C P  G C C+       C  PC      
Sbjct: 80  GFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHG 139

Query: 483 ------------PGTWGFSCNASCQCAHEAV-CSPQTGACTCTPGWHGAHCQL------- 522
                       PG W  +C   CQC   A  C   TGAC C PGW G  C         
Sbjct: 140 RCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGS 199

Query: 523 ---------PCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWG 573
                     C  G +G  C  +C+C     C    G C C  G+ GARC L CP G  G
Sbjct: 200 PCEQDSGRCACRPGWWGPECQQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHG 258

Query: 574 VNCSNTC-TCKNGGTCLPENGNCV-CAPGFRGPSCQRSCQPGRYGKRCVP-CK-CANHSF 629
           V C+++C  CK+   C P+ G+C  C PG+ G  CQ+ C PG +G+ C   C  C +   
Sbjct: 259 VQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEA 318

Query: 630 CHPSNGTCY-CLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTG 688
           C P  G C  C  GW GP C  PCP G +GE+C  TC     G+C    G C+C  G+ G
Sbjct: 319 CEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWG 378

Query: 689 HHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGAC 723
             C   CP G  G NCS PC+C P   CHP +G+C
Sbjct: 379 PSCNASCPAGFHGNNCSVPCEC-PEGLCHPVSGSC 412



 Score =  250 bits (639), Expect = 4e-66
 Identities = 138/398 (34%), Positives = 173/398 (43%), Gaps = 76/398 (19%)

Query: 88  LQCCHGFYESRGFC-VPLCA--QECVHGR-CVAPNQCQCVPGWRGDDCSSECAPGMWGPQ 143
           LQCC G+ +    C +P+C     C     CV P  C+C PG+ G  CSS C    WGP 
Sbjct: 39  LQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPD 98

Query: 144 CDK------------------------------PCSCGNNSSCDPKSGVCSCPSGLQPPN 173
           C +                              PC+CG +  CDP +GVC C  G     
Sbjct: 99  CRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSST 158

Query: 174 CLQP------------------CTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPS 215
           C +P                  C PG++G  C FRC CHG+PC+  +G C C     GP 
Sbjct: 159 CRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPE 218

Query: 216 CDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQE 275
           C   C              C  G       G C+CPPG+ G  C LPCP G HG  C+  
Sbjct: 219 CQQQC-------------ECVRGRC-SAASGECTCPPGFRGARCELPCPAGSHGVQCAHS 264

Query: 276 C-RCHNGGLCDRFTGQCR-CAPGYTGDRCREECPVGRFGQDCAETC-DCAPDARCFPANG 332
           C RC +   C   TG C  C PG+ G +C++ C  G FG+ C + C  C     C P  G
Sbjct: 265 CGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTG 324

Query: 333 AC-LCEHGFTGDRCTDRLCPDGFYGLSCQAPC-TCDREHSLSCHPMNGECSCLPGWAGLH 390
            C  C+ G+ G RC D  CP G +G  C + C TC +    SC  + G+C C  G+ G  
Sbjct: 325 HCQRCDPGWLGPRCEDP-CPTGTFGEDCGSTCPTCVQG---SCDTVTGDCVCSAGYWGPS 380

Query: 391 CNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPG 428
           CN SCP   HG  C   C C   G+C   SG CQ   G
Sbjct: 381 CNASCPAGFHGNNCSVPCECPE-GLCHPVSGSCQPGSG 417



 Score =  151 bits (381), Expect = 4e-36
 Identities = 85/274 (31%), Positives = 104/274 (37%), Gaps = 60/274 (21%)

Query: 484 GTWGFSCNASCQCAHEAVCSPQTGACTCTPGWH--GAHCQLPCPKGQFGEGCASRCDCDH 541
           GT G   +   Q  H  V S  +    C  GW      C +P  +G          D   
Sbjct: 16  GTQGSELDPKGQ--HVCVASSPSAELQCCAGWRQKDQECTIPICEGP---------DACQ 64

Query: 542 SDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGF 601
            D      G C+C+ G+ GA C   CP   WG +C  +C C   G C P  G C      
Sbjct: 65  KDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGAC------ 118

Query: 602 RGPSCQRSCQPGRYGKRC-VPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCP------- 653
                   CQ  R+G RC  PC C  H  C P+ G C+C  GW    C +PC        
Sbjct: 119 -------QCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAAR 171

Query: 654 -----------PGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGA 702
                      PG WG  C+  C CH G  C    G C C  GW             +G 
Sbjct: 172 CEQATGACVCKPGWWGRRCSFRCNCH-GSPCEQDSGRCACRPGW-------------WGP 217

Query: 703 NCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRI 736
            C Q C+C  G +C   +G C CPPG  GA C +
Sbjct: 218 ECQQQCECVRG-RCSAASGECTCPPGFRGARCEL 250



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 51/157 (32%), Positives = 61/157 (38%), Gaps = 30/157 (19%)

Query: 53  EPCERPWEGPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHG-FYESRGFCVPLCAQECVH 111
           E CE  W G   C QP                     C  G F ES   C   C   C H
Sbjct: 282 ESCEPGWNGTQ-CQQP---------------------CLPGTFGES---CEQQCPH-CRH 315

Query: 112 GRCVAPN--QCQ-CVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSG 168
           G    P+   CQ C PGW G  C   C  G +G  C   C      SCD  +G C C +G
Sbjct: 316 GEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAG 375

Query: 169 LQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGAC 205
              P+C   C  G++G  C   C+C    C P +G+C
Sbjct: 376 YWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSC 412


>gi|33598929 scavenger receptor class F, member 1 isoform 1
           precursor [Homo sapiens]
          Length = 830

 Score =  279 bits (713), Expect = 1e-74
 Identities = 149/401 (37%), Positives = 183/401 (45%), Gaps = 50/401 (12%)

Query: 240 VFQTPQGSCSCPPGWM--GTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGY 297
           V  +P     C  GW      C++P  EG   P+      C    +C +  G CRC PG+
Sbjct: 31  VASSPSAELQCCAGWRQKDQECTIPICEG---PDA-----CQKDEVCVK-PGLCRCKPGF 81

Query: 298 TGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRL-------- 349
            G  C   CP   +G DC E+C C P  +C PA GAC C+    G RC            
Sbjct: 82  FGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRC 141

Query: 350 --------CPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCN-------ES 394
                   C  G++  +C+ PC C+   +  C    G C C PGW G  C+         
Sbjct: 142 DPATGVCHCEPGWWSSTCRRPCQCNTA-AARCEQATGACVCKPGWWGRRCSFRCNCHGSP 200

Query: 395 CPQDTH---------GPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGV 445
           C QD+          GP CQ+ C C+ G  C A SG C C PG+ G  C   CP  ++GV
Sbjct: 201 CEQDSGRCACRPGWWGPECQQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGV 259

Query: 446 NCSARCS-CENAIACSPIDGECV-CKEGWQRGNCSVPCPPGTWGFSCNASC-QCAHEAVC 502
            C+  C  C++   CSP  G C  C+ GW    C  PC PGT+G SC   C  C H   C
Sbjct: 260 QCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEAC 319

Query: 503 SPQTGACT-CTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGA 561
            P TG C  C PGW G  C+ PCP G FGE C S C       CD V G C C AG+ G 
Sbjct: 320 EPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGP 379

Query: 562 RCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFR 602
            C+ SCP G  G NCS  C C   G C P +G+C    G R
Sbjct: 380 SCNASCPAGFHGNNCSVPCECPE-GLCHPVSGSCQPGSGSR 419



 Score =  271 bits (692), Expect = 3e-72
 Identities = 139/395 (35%), Positives = 173/395 (43%), Gaps = 48/395 (12%)

Query: 368 EHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAP 427
           +H       + E  C  GW          Q+   P C+    C    VC    GLC+C P
Sbjct: 27  QHVCVASSPSAELQCCAGW------RQKDQECTIPICEGPDACQKDEVC-VKPGLCRCKP 79

Query: 428 GYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCP----- 482
           G+ G HC+S CP   +G +C   C C     C P  G C C+       C  PC      
Sbjct: 80  GFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHG 139

Query: 483 ------------PGTWGFSCNASCQCAHEAV-CSPQTGACTCTPGWHGAHCQL------- 522
                       PG W  +C   CQC   A  C   TGAC C PGW G  C         
Sbjct: 140 RCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGS 199

Query: 523 ---------PCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWG 573
                     C  G +G  C  +C+C     C    G C C  G+ GARC L CP G  G
Sbjct: 200 PCEQDSGRCACRPGWWGPECQQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHG 258

Query: 574 VNCSNTC-TCKNGGTCLPENGNCV-CAPGFRGPSCQRSCQPGRYGKRCVP-CK-CANHSF 629
           V C+++C  CK+   C P+ G+C  C PG+ G  CQ+ C PG +G+ C   C  C +   
Sbjct: 259 VQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEA 318

Query: 630 CHPSNGTCY-CLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTG 688
           C P  G C  C  GW GP C  PCP G +GE+C  TC     G+C    G C+C  G+ G
Sbjct: 319 CEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWG 378

Query: 689 HHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGAC 723
             C   CP G  G NCS PC+C P   CHP +G+C
Sbjct: 379 PSCNASCPAGFHGNNCSVPCEC-PEGLCHPVSGSC 412



 Score =  250 bits (639), Expect = 4e-66
 Identities = 138/398 (34%), Positives = 173/398 (43%), Gaps = 76/398 (19%)

Query: 88  LQCCHGFYESRGFC-VPLCA--QECVHGR-CVAPNQCQCVPGWRGDDCSSECAPGMWGPQ 143
           LQCC G+ +    C +P+C     C     CV P  C+C PG+ G  CSS C    WGP 
Sbjct: 39  LQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPD 98

Query: 144 CDK------------------------------PCSCGNNSSCDPKSGVCSCPSGLQPPN 173
           C +                              PC+CG +  CDP +GVC C  G     
Sbjct: 99  CRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSST 158

Query: 174 CLQP------------------CTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPS 215
           C +P                  C PG++G  C FRC CHG+PC+  +G C C     GP 
Sbjct: 159 CRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPE 218

Query: 216 CDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQE 275
           C   C              C  G       G C+CPPG+ G  C LPCP G HG  C+  
Sbjct: 219 CQQQC-------------ECVRGRC-SAASGECTCPPGFRGARCELPCPAGSHGVQCAHS 264

Query: 276 C-RCHNGGLCDRFTGQCR-CAPGYTGDRCREECPVGRFGQDCAETC-DCAPDARCFPANG 332
           C RC +   C   TG C  C PG+ G +C++ C  G FG+ C + C  C     C P  G
Sbjct: 265 CGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTG 324

Query: 333 AC-LCEHGFTGDRCTDRLCPDGFYGLSCQAPC-TCDREHSLSCHPMNGECSCLPGWAGLH 390
            C  C+ G+ G RC D  CP G +G  C + C TC +    SC  + G+C C  G+ G  
Sbjct: 325 HCQRCDPGWLGPRCEDP-CPTGTFGEDCGSTCPTCVQG---SCDTVTGDCVCSAGYWGPS 380

Query: 391 CNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPG 428
           CN SCP   HG  C   C C   G+C   SG CQ   G
Sbjct: 381 CNASCPAGFHGNNCSVPCECPE-GLCHPVSGSCQPGSG 417



 Score =  151 bits (381), Expect = 4e-36
 Identities = 85/274 (31%), Positives = 104/274 (37%), Gaps = 60/274 (21%)

Query: 484 GTWGFSCNASCQCAHEAVCSPQTGACTCTPGWH--GAHCQLPCPKGQFGEGCASRCDCDH 541
           GT G   +   Q  H  V S  +    C  GW      C +P  +G          D   
Sbjct: 16  GTQGSELDPKGQ--HVCVASSPSAELQCCAGWRQKDQECTIPICEGP---------DACQ 64

Query: 542 SDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGF 601
            D      G C+C+ G+ GA C   CP   WG +C  +C C   G C P  G C      
Sbjct: 65  KDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGAC------ 118

Query: 602 RGPSCQRSCQPGRYGKRC-VPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCP------- 653
                   CQ  R+G RC  PC C  H  C P+ G C+C  GW    C +PC        
Sbjct: 119 -------QCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAAR 171

Query: 654 -----------PGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGA 702
                      PG WG  C+  C CH G  C    G C C  GW             +G 
Sbjct: 172 CEQATGACVCKPGWWGRRCSFRCNCH-GSPCEQDSGRCACRPGW-------------WGP 217

Query: 703 NCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRI 736
            C Q C+C  G +C   +G C CPPG  GA C +
Sbjct: 218 ECQQQCECVRG-RCSAASGECTCPPGFRGARCEL 250



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 51/157 (32%), Positives = 61/157 (38%), Gaps = 30/157 (19%)

Query: 53  EPCERPWEGPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHG-FYESRGFCVPLCAQECVH 111
           E CE  W G   C QP                     C  G F ES   C   C   C H
Sbjct: 282 ESCEPGWNGTQ-CQQP---------------------CLPGTFGES---CEQQCPH-CRH 315

Query: 112 GRCVAPN--QCQ-CVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSG 168
           G    P+   CQ C PGW G  C   C  G +G  C   C      SCD  +G C C +G
Sbjct: 316 GEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAG 375

Query: 169 LQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGAC 205
              P+C   C  G++G  C   C+C    C P +G+C
Sbjct: 376 YWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSC 412


>gi|24586659 scavenger receptor class F, member 2 isoform 1 [Homo
           sapiens]
          Length = 870

 Score =  261 bits (667), Expect = 2e-69
 Identities = 135/411 (32%), Positives = 175/411 (42%), Gaps = 60/411 (14%)

Query: 249 SCPPGW--MGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREEC 306
           +C  GW   G  C +   EG           C    +C R  G+CRC  GY G  C  +C
Sbjct: 63  TCCAGWRQQGDECGIAVCEG--------NSTCSENEVCVR-PGECRCRHGYFGANCDTKC 113

Query: 307 PVGRFGQDCAETCDCAPDARCFPANG---------------ACLCEHGFTGDRCTDRLCP 351
           P   +G DC E C C P  +C    G               AC C+HG    R     C 
Sbjct: 114 PRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCE 173

Query: 352 DGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCL 411
            G++G  C + C C    +  C P  G C C  GW G  CN  C                
Sbjct: 174 PGWWGAQCASACYCSA--TSRCDPQTGACLCHAGWWGRSCNNQC--------------AC 217

Query: 412 HGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEG 471
           +   C+  SG CQC                T+G  C   C C     C P+DG C C+ G
Sbjct: 218 NSSPCEQQSGRCQCRER-------------TFGARCDRYCQCFRG-RCHPVDGTCACEPG 263

Query: 472 WQRGNCSVPCPPGTWGFSCNASC-QCAHEAVCSPQTGAC-TCTPGWHGAHCQLPCPKGQF 529
           ++   C  PCP G +G  C   C QC  +  C+   G C TC PGW+G  C  PC  G +
Sbjct: 264 YRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFY 323

Query: 530 GEGCASRCD-CDHSDGCDPVHGRC-QCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGT 587
           GEGC+ RC  C     C+ V G+C +C AGW+G RC   C  G +G +C+  C     G 
Sbjct: 324 GEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGH 383

Query: 588 CLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCY 638
           C  ++G C+C+PG  GP C  +C PG +G  C      +   C P  G C+
Sbjct: 384 CDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCDPVTGACH 434



 Score =  248 bits (633), Expect = 2e-65
 Identities = 137/423 (32%), Positives = 184/423 (43%), Gaps = 55/423 (13%)

Query: 77  RQVVKTDHRQRLQCCHGFYESRGFC-VPLCA--QECVHGR-CVAPNQCQCVPGWRGDDCS 132
           R V +    Q   CC G+ +    C + +C     C     CV P +C+C  G+ G +C 
Sbjct: 51  RNVCRAPGSQVPTCCAGWRQQGDECGIAVCEGNSTCSENEVCVRPGECRCRHGYFGANCD 110

Query: 133 SECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQ 192
           ++C    WGP C + CSC  +  C+  +G C+C +               +G  C+  CQ
Sbjct: 111 TKCPRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARR-------------WGARCEHACQ 157

Query: 193 CHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQ-GSCSCP 251
           C    C P++GAC C     G  C  +C       +C +T  C        PQ G+C C 
Sbjct: 158 CQHGTCHPRSGACRCEPGWWGAQCASAC-------YCSATSRCD-------PQTGACLCH 203

Query: 252 PGWMGTICS----------------LPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAP 295
            GW G  C+                  C E   G  C + C+C  G  C    G C C P
Sbjct: 204 AGWWGRSCNNQCACNSSPCEQQSGRCQCRERTFGARCDRYCQCFRGR-CHPVDGTCACEP 262

Query: 296 GYTGDRCREECPVGRFGQDCAETC-DCAPDARCFPANGACL-CEHGFTGDRCTDRLCPDG 353
           GY G  CRE CP G +G  C   C  C     C  A G CL CE G+ G +C D+ C  G
Sbjct: 263 GYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKC-DQPCATG 321

Query: 354 FYGLSCQAPCTCDREHSLSCHPMNGECS-CLPGWAGLHCNESCPQDTHGPGCQEHCLCLH 412
           FYG  C   C   R+   +C+ + G+C+ C  GW G  C   C   T+G  C   C    
Sbjct: 322 FYGEGCSHRCPPCRDGH-ACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCG 380

Query: 413 GGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGW 472
            G C   SG C C+PG  GPHC   CPP  +G +C+  CSC     C P+ G C  +   
Sbjct: 381 SGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHED-TCDPVTGACHLETNQ 439

Query: 473 QRG 475
           ++G
Sbjct: 440 RKG 442



 Score =  237 bits (605), Expect = 4e-62
 Identities = 204/762 (26%), Positives = 286/762 (37%), Gaps = 110/762 (14%)

Query: 359  CQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQA 418
            C+   TC  E+ +   P  GEC C  G+ G +C+  CP+   GP C+E C C   G C+ 
Sbjct: 80   CEGNSTCS-ENEVCVRP--GECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHPHGQCED 136

Query: 419  TSGLCQCAPGYTGPHC----------------ASLCPPDTYGVNCSARCSCENAIACSPI 462
             +G C C     G  C                A  C P  +G  C++ C C     C P 
Sbjct: 137  VTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCEPGWWGAQCASACYCSATSRCDPQ 196

Query: 463  DGECVCKEGW------------------QRGNCSVPCPPGTWGFSCNASCQCAHEAVCSP 504
             G C+C  GW                  Q G C   C   T+G  C+  CQC     C P
Sbjct: 197  TGACLCHAGWWGRSCNNQCACNSSPCEQQSGRCQ--CRERTFGARCDRYCQC-FRGRCHP 253

Query: 505  QTGACTCTPGWHGAHCQLPCPKGQFGEGCASRC-DCDHSDGCDPVHGRC-QCQAGWMGAR 562
              G C C PG+ G +C+ PCP G +G GC  RC  C     C    GRC  C+ GW G +
Sbjct: 254  VDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTK 313

Query: 563  CHLSCPEGLWGVNCSNTCT-CKNGGTCLPENGNCV-CAPGFRGPSCQRSCQPGRYGKRCV 620
            C   C  G +G  CS+ C  C++G  C    G C  C  G+ G  C+  C  G YG+ C 
Sbjct: 314  CDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCA 373

Query: 621  -PCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHG------GTC 673
              C       C   +G C C  G  GP C+  CPPG  G +CAQ C CH        G C
Sbjct: 374  FVCADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCDPVTGAC 433

Query: 674  HPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQC---GPGEKCHPET----GACVCP 726
            H +       +G      L  C L +    C   C C    P  +  P      G    P
Sbjct: 434  HLETNQRKGVMGAGALLVLLVCLLLSLLGCC---CACRGKDPTRRPRPRRELSLGRKKAP 490

Query: 727  PGHSGAPCRIGIQEPFTVM-----PTTPVAYNSLGAVIGIAVLG--------SLVVALVA 773
                G   RI ++ P   +     P   VA++ L   +  + L         S   +  A
Sbjct: 491  HRLCGRFSRISMKLPRIPLRRQKLPKVVVAHHDLDNTLNCSFLEPPSGLEQPSPSWSSRA 550

Query: 774  LFIGYRHWQKGKEHHHLAVAYSSGRLDGSEYVMPDVPPSYSHYYSNPSYHTLSQCSPNPP 833
             F  +    +G  +    V +     +  +  +P VP         P     S     P 
Sbjct: 551  SFSSFDTTDEGPVY---CVPHEEAPAESRDPEVPTVPAEAPAPSPVPLTTPASAEEAIPL 607

Query: 834  PPNK--------VPGP---LFASLQNPE-RPGGAQGHDNHTTLPADWKHRREPPPGPLDR 881
            P +         V GP   L+A +   E RP  A+G     +L    + R+ PPP P  +
Sbjct: 608  PASSDSERSASSVEGPGGALYARVARREARPARARGEIGGLSLSPSPERRKPPPPDPATK 667

Query: 882  GS-SRLDRSYSYSYSN---GPGPFYNKGLISEEELGASVASLSS---ENPYATIRD-LPS 933
               S +   +S + +     P P  ++   S  +   + +  S+   E+     RD  P 
Sbjct: 668  PKVSWIHGKHSAAAAGRAPSPPPPGSEAAPSPSKRKRTPSDKSAHTVEHGSPRTRDPTPR 727

Query: 934  LPGGPRESSYMEMKGPPSGSPPRQPPQFWDSQRRRQPQPQRDSGTY------EQPSPLIH 987
             PG P E++ +    PP       P       RRR P  + ++ +        +   L  
Sbjct: 728  PPGLPEEATALAAPSPPRARARAAPRPLGAHGRRRSPAKRAEAASMLAADVRGKTRSLGR 787

Query: 988  DRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYDLPPVRHPPS 1029
               ++G+Q P     PP      K S  P      P R PP+
Sbjct: 788  AEVALGAQGPREKPAPP---QKAKRSVPPA----SPARAPPA 822



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 32/110 (29%), Positives = 41/110 (37%), Gaps = 11/110 (10%)

Query: 632 PSNGTCYCLAGWT--GPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGH 689
           P +    C AGW   G +C            C     C     C  + G C C  G+ G 
Sbjct: 57  PGSQVPTCCAGWRQQGDECGIAV--------CEGNSTCSENEVC-VRPGECRCRHGYFGA 107

Query: 690 HCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRIGIQ 739
           +C   CP   +G +C + C C P  +C   TG C C     GA C    Q
Sbjct: 108 NCDTKCPRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQ 157


>gi|33598937 scavenger receptor class F, member 2 isoform 2 [Homo
           sapiens]
          Length = 865

 Score =  261 bits (667), Expect = 2e-69
 Identities = 135/411 (32%), Positives = 175/411 (42%), Gaps = 60/411 (14%)

Query: 249 SCPPGW--MGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREEC 306
           +C  GW   G  C +   EG           C    +C R  G+CRC  GY G  C  +C
Sbjct: 63  TCCAGWRQQGDECGIAVCEG--------NSTCSENEVCVR-PGECRCRHGYFGANCDTKC 113

Query: 307 PVGRFGQDCAETCDCAPDARCFPANG---------------ACLCEHGFTGDRCTDRLCP 351
           P   +G DC E C C P  +C    G               AC C+HG    R     C 
Sbjct: 114 PRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCE 173

Query: 352 DGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCL 411
            G++G  C + C C    +  C P  G C C  GW G  CN  C                
Sbjct: 174 PGWWGAQCASACYCSA--TSRCDPQTGACLCHAGWWGRSCNNQC--------------AC 217

Query: 412 HGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEG 471
           +   C+  SG CQC                T+G  C   C C     C P+DG C C+ G
Sbjct: 218 NSSPCEQQSGRCQCRER-------------TFGARCDRYCQCFRG-RCHPVDGTCACEPG 263

Query: 472 WQRGNCSVPCPPGTWGFSCNASC-QCAHEAVCSPQTGAC-TCTPGWHGAHCQLPCPKGQF 529
           ++   C  PCP G +G  C   C QC  +  C+   G C TC PGW+G  C  PC  G +
Sbjct: 264 YRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFY 323

Query: 530 GEGCASRCD-CDHSDGCDPVHGRC-QCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGT 587
           GEGC+ RC  C     C+ V G+C +C AGW+G RC   C  G +G +C+  C     G 
Sbjct: 324 GEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGH 383

Query: 588 CLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCY 638
           C  ++G C+C+PG  GP C  +C PG +G  C      +   C P  G C+
Sbjct: 384 CDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCDPVTGACH 434



 Score =  248 bits (633), Expect = 2e-65
 Identities = 137/423 (32%), Positives = 184/423 (43%), Gaps = 55/423 (13%)

Query: 77  RQVVKTDHRQRLQCCHGFYESRGFC-VPLCA--QECVHGR-CVAPNQCQCVPGWRGDDCS 132
           R V +    Q   CC G+ +    C + +C     C     CV P +C+C  G+ G +C 
Sbjct: 51  RNVCRAPGSQVPTCCAGWRQQGDECGIAVCEGNSTCSENEVCVRPGECRCRHGYFGANCD 110

Query: 133 SECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQ 192
           ++C    WGP C + CSC  +  C+  +G C+C +               +G  C+  CQ
Sbjct: 111 TKCPRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARR-------------WGARCEHACQ 157

Query: 193 CHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQ-GSCSCP 251
           C    C P++GAC C     G  C  +C       +C +T  C        PQ G+C C 
Sbjct: 158 CQHGTCHPRSGACRCEPGWWGAQCASAC-------YCSATSRCD-------PQTGACLCH 203

Query: 252 PGWMGTICS----------------LPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAP 295
            GW G  C+                  C E   G  C + C+C  G  C    G C C P
Sbjct: 204 AGWWGRSCNNQCACNSSPCEQQSGRCQCRERTFGARCDRYCQCFRGR-CHPVDGTCACEP 262

Query: 296 GYTGDRCREECPVGRFGQDCAETC-DCAPDARCFPANGACL-CEHGFTGDRCTDRLCPDG 353
           GY G  CRE CP G +G  C   C  C     C  A G CL CE G+ G +C D+ C  G
Sbjct: 263 GYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKC-DQPCATG 321

Query: 354 FYGLSCQAPCTCDREHSLSCHPMNGECS-CLPGWAGLHCNESCPQDTHGPGCQEHCLCLH 412
           FYG  C   C   R+   +C+ + G+C+ C  GW G  C   C   T+G  C   C    
Sbjct: 322 FYGEGCSHRCPPCRDGH-ACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCG 380

Query: 413 GGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGW 472
            G C   SG C C+PG  GPHC   CPP  +G +C+  CSC     C P+ G C  +   
Sbjct: 381 SGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHED-TCDPVTGACHLETNQ 439

Query: 473 QRG 475
           ++G
Sbjct: 440 RKG 442



 Score =  239 bits (610), Expect = 1e-62
 Identities = 191/687 (27%), Positives = 254/687 (36%), Gaps = 126/687 (18%)

Query: 404  CQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPID 463
            C+ +  C    VC    G C+C  GY G +C + CP   +G +C   CSC     C  + 
Sbjct: 80   CEGNSTCSENEVC-VRPGECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHPHGQCEDVT 138

Query: 464  GECVCK-EGW----------QRGNC-----SVPCPPGTWGFSCNASCQCAHEAVCSPQTG 507
            G+C C    W          Q G C     +  C PG WG  C ++C C+  + C PQTG
Sbjct: 139  GQCTCHARRWGARCEHACQCQHGTCHPRSGACRCEPGWWGAQCASACYCSATSRCDPQTG 198

Query: 508  ACTCTPGWHGAHC----------------QLPCPKGQFGEGCASRCDCDHSDGCDPVHGR 551
            AC C  GW G  C                +  C +  FG  C   C C     C PV G 
Sbjct: 199  ACLCHAGWWGRSCNNQCACNSSPCEQQSGRCQCRERTFGARCDRYCQCFRGR-CHPVDGT 257

Query: 552  CQCQAGWMGARCHLSCPEGLWGVNCSNTC-TCKNGGTCLPENGNCV-CAPGFRGPSCQRS 609
            C C+ G+ G  C   CP G +G+ C   C  CK    C    G C+ C PG+ G  C + 
Sbjct: 258  CACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQP 317

Query: 610  CQPGRYGK----RCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTC 665
            C  G YG+    RC PC+   H+  H +     C AGW G  C   C  G +GE+CA  C
Sbjct: 318  CATGFYGEGCSHRCPPCR-DGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVC 376

Query: 666  QCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVC 725
                 G C  Q G C+C  G  G HC   CP G  GA+C+Q C C   + C P TGAC  
Sbjct: 377  ADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHE-DTCDPVTGAC-- 433

Query: 726  PPGHSGAPCRIGIQEPFTVMPTTPVAYNSLGAVIGIAVLGSLVVALVALFIGYRHWQKGK 785
                                    +  N    V+G   L  L+V L+   +G     +GK
Sbjct: 434  -----------------------HLETNQRKGVMGAGALLVLLVCLLLSLLGCCCACRGK 470

Query: 786  EHHHLAVAYS--------SGRLDGSEYVMPDVPPSYSHYYSNPSYH-----TLSQCSPNP 832
            +     ++           GR       +P +P            H     TL+     P
Sbjct: 471  DPTRRELSLGRKKAPHRLCGRFSRISMKLPRIPLRRQKLPKVVVAHHDLDNTLNCSFLEP 530

Query: 833  PPPNKVPGPLFASLQN---------------PERPGGAQGHDNHT-TLPADWKHRREPPP 876
            P   + P P ++S  +               P     A+  D    T+PA+      P P
Sbjct: 531  PSGLEQPSPSWSSRASFSSFDTTDEGPVYCVPHEEAPAESRDPEVPTVPAE---APAPSP 587

Query: 877  GPLDRGSS---------RLDRSYSYSYSNGPGPFYNKGLISEEELGA----SVASLSSEN 923
             PL   +S           D   S S   GPG      +   E   A     +  LS   
Sbjct: 588  VPLTTPASAEEAIPLPASSDSERSASSVEGPGGALYARVARREARPARARGEIGGLSLSP 647

Query: 924  PYATIRDLPSLPGGPRESSYMEMK-------GPPSGSPPRQPPQFWDSQRRRQPQPQRDS 976
                 +  P  P    + S++  K         PS  PP        S+R+R P   + +
Sbjct: 648  SPERRKPPPPDPATKPKVSWIHGKHSAAAAGRAPSPPPPGSEAAPSPSKRKRTPS-DKSA 706

Query: 977  GTYEQPSPLIHDRDSVGSQPPLPPGLP 1003
             T E  SP   D        P PPGLP
Sbjct: 707  HTVEHGSPRTRD------PTPRPPGLP 727



 Score =  238 bits (608), Expect = 2e-62
 Identities = 203/757 (26%), Positives = 285/757 (37%), Gaps = 105/757 (13%)

Query: 359  CQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQA 418
            C+   TC  E+ +   P  GEC C  G+ G +C+  CP+   GP C+E C C   G C+ 
Sbjct: 80   CEGNSTCS-ENEVCVRP--GECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHPHGQCED 136

Query: 419  TSGLCQCAPGYTGPHC----------------ASLCPPDTYGVNCSARCSCENAIACSPI 462
             +G C C     G  C                A  C P  +G  C++ C C     C P 
Sbjct: 137  VTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCEPGWWGAQCASACYCSATSRCDPQ 196

Query: 463  DGECVCKEGW------------------QRGNCSVPCPPGTWGFSCNASCQCAHEAVCSP 504
             G C+C  GW                  Q G C   C   T+G  C+  CQC     C P
Sbjct: 197  TGACLCHAGWWGRSCNNQCACNSSPCEQQSGRCQ--CRERTFGARCDRYCQC-FRGRCHP 253

Query: 505  QTGACTCTPGWHGAHCQLPCPKGQFGEGCASRC-DCDHSDGCDPVHGRC-QCQAGWMGAR 562
              G C C PG+ G +C+ PCP G +G GC  RC  C     C    GRC  C+ GW G +
Sbjct: 254  VDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTK 313

Query: 563  CHLSCPEGLWGVNCSNTCT-CKNGGTCLPENGNCV-CAPGFRGPSCQRSCQPGRYGKRCV 620
            C   C  G +G  CS+ C  C++G  C    G C  C  G+ G  C+  C  G YG+ C 
Sbjct: 314  CDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCA 373

Query: 621  -PCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHG------GTC 673
              C       C   +G C C  G  GP C+  CPPG  G +CAQ C CH        G C
Sbjct: 374  FVCADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCDPVTGAC 433

Query: 674  HPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPET--GACVCPPGHSG 731
            H +       +G      L  C L +    C   C C   +    E   G    P    G
Sbjct: 434  HLETNQRKGVMGAGALLVLLVCLLLSLLGCC---CACRGKDPTRRELSLGRKKAPHRLCG 490

Query: 732  APCRIGIQEPFTVM-----PTTPVAYNSLGAVIGIAVLG--------SLVVALVALFIGY 778
               RI ++ P   +     P   VA++ L   +  + L         S   +  A F  +
Sbjct: 491  RFSRISMKLPRIPLRRQKLPKVVVAHHDLDNTLNCSFLEPPSGLEQPSPSWSSRASFSSF 550

Query: 779  RHWQKGKEHHHLAVAYSSGRLDGSEYVMPDVPPSYSHYYSNPSYHTLSQCSPNPPPPNK- 837
                +G  +    V +     +  +  +P VP         P     S     P P +  
Sbjct: 551  DTTDEGPVY---CVPHEEAPAESRDPEVPTVPAEAPAPSPVPLTTPASAEEAIPLPASSD 607

Query: 838  -------VPGP---LFASLQNPE-RPGGAQGHDNHTTLPADWKHRREPPPGPLDRGS-SR 885
                   V GP   L+A +   E RP  A+G     +L    + R+ PPP P  +   S 
Sbjct: 608  SERSASSVEGPGGALYARVARREARPARARGEIGGLSLSPSPERRKPPPPDPATKPKVSW 667

Query: 886  LDRSYSYSYSN---GPGPFYNKGLISEEELGASVASLSS---ENPYATIRD-LPSLPGGP 938
            +   +S + +     P P  ++   S  +   + +  S+   E+     RD  P  PG P
Sbjct: 668  IHGKHSAAAAGRAPSPPPPGSEAAPSPSKRKRTPSDKSAHTVEHGSPRTRDPTPRPPGLP 727

Query: 939  RESSYMEMKGPPSGSPPRQPPQFWDSQRRRQPQPQRDSGTY------EQPSPLIHDRDSV 992
             E++ +    PP       P       RRR P  + ++ +        +   L     ++
Sbjct: 728  EEATALAAPSPPRARARAAPRPLGAHGRRRSPAKRAEAASMLAADVRGKTRSLGRAEVAL 787

Query: 993  GSQPPLPPGLPPGHYDSPKNSHIPGHYDLPPVRHPPS 1029
            G+Q P     PP      K S  P      P R PP+
Sbjct: 788  GAQGPREKPAPP---QKAKRSVPPA----SPARAPPA 817



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 32/110 (29%), Positives = 41/110 (37%), Gaps = 11/110 (10%)

Query: 632 PSNGTCYCLAGWT--GPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGH 689
           P +    C AGW   G +C            C     C     C  + G C C  G+ G 
Sbjct: 57  PGSQVPTCCAGWRQQGDECGIAV--------CEGNSTCSENEVC-VRPGECRCRHGYFGA 107

Query: 690 HCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRIGIQ 739
           +C   CP   +G +C + C C P  +C   TG C C     GA C    Q
Sbjct: 108 NCDTKCPRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQ 157


>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
          Length = 4242

 Score =  255 bits (651), Expect = 2e-67
 Identities = 225/750 (30%), Positives = 283/750 (37%), Gaps = 232/750 (30%)

Query: 55  CERPWEGPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRC 114
           CE  W GP TC  PT        ++  +        C      +G         CV GRC
Sbjct: 158 CEPGWGGP-TCSDPTDA------EIPPSSPPSASGSCPDDCNDQG--------RCVRGRC 202

Query: 115 VAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNC 174
           V      C PG+ G  C        W P C  P  C     C    GVC C +G   P+C
Sbjct: 203 V------CFPGYTGPSCG-------W-PSC--PGDCQGRGRC--VQGVCVCRAGFSGPDC 244

Query: 175 LQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDV-SCSQGTSGFFCPSTH 233
            Q   P      C  R +C G       G C C    TG  C + SC +G     C    
Sbjct: 245 SQRSCPR----GCSQRGRCEG-------GRCVCDPGYTGDDCGMRSCPRG-----CSQRG 288

Query: 234 SCQNGGVFQTPQGSCSCPPGWMGTICSL-PCPEGFHGPNCSQECRCHNGGLCDRFTGQCR 292
            C+NG         C C PG+ G  C +  CP G     CSQ  RC +G        +C 
Sbjct: 289 RCENG--------RCVCNPGYTGEDCGVRSCPRG-----CSQRGRCKDG--------RCV 327

Query: 293 CAPGYTGDRC------------------REECPVGRFGQDCA-ETC--DCAPDARCFPAN 331
           C PGYTG+ C                  R  C  G  G+DC+  TC  DC    RC   +
Sbjct: 328 CDPGYTGEDCGTRSCPWDCGEGGRCVDGRCVCWPGYTGEDCSTRTCPRDCRGRGRC--ED 385

Query: 332 GACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHC 391
           G C+C+ G++GD C  R CP       C     C+          +G C C PG+ G  C
Sbjct: 386 GECICDTGYSGDDCGVRSCPG-----DCNQRGRCE----------DGRCVCWPGYTGTDC 430

Query: 392 -NESCPQDTHGPGCQEH--CLCLHG------------GVCQAT----SGLCQCAPGYTGP 432
            + +CP+D  G G  E+  C+C  G            G C+      SG C C PGYTG 
Sbjct: 431 GSRACPRDCRGRGRCENGVCVCNAGYSGEDCGVRSCPGDCRGRGRCESGRCMCWPGYTGR 490

Query: 433 HCAS-LCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCN 491
            C +  CP D     C  R  C        +DG CVC  G+   +C     PG       
Sbjct: 491 DCGTRACPGD-----CRGRGRC--------VDGRCVCNPGFTGEDCGSRRCPG------- 530

Query: 492 ASCQCAHEAVCSPQTGACTCTPGWHGAHCQL-PCPKGQFGEGCASRCDCDHSDGCDPVHG 550
               C    +C  + G C C  G+ G  C    CP G     C  R  C        + G
Sbjct: 531 ---DCRGHGLC--EDGVCVCDAGYSGEDCSTRSCPGG-----CRGRGQC--------LDG 572

Query: 551 RCQCQAGWMGARCHL-SCP-----------------EGLWGVNCS-NTC--TCKNGGTCL 589
           RC C+ G+ G  C +  CP                 EG    +CS  TC   C   G C 
Sbjct: 573 RCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGRC- 631

Query: 590 PENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCS 649
            E G C+C PG+ GP+C           R  P  C     C    G C C  G+ G DC 
Sbjct: 632 -EEGRCLCDPGYTGPTC---------ATRMCPADCRGRGRC--VQGVCLCHVGYGGEDCG 679

Query: 650 QPCPPGHWGENCAQTCQCHHGGTCHPQD----GSCICPLGWTGHHC-LEGCPLGTFGANC 704
           Q  PP       A  C     G C P++    G C+C  G+ G  C ++ CP      +C
Sbjct: 680 QEEPP-------ASACP----GGCGPRELCRAGQCVCVEGFRGPDCAIQTCP-----GDC 723

Query: 705 SQPCQCGPGEKCHPETGACVCPPGHSGAPC 734
                 G GE CH   G+CVC  G++G  C
Sbjct: 724 R-----GRGE-CHD--GSCVCKDGYAGEDC 745



 Score =  238 bits (606), Expect = 3e-62
 Identities = 203/681 (29%), Positives = 249/681 (36%), Gaps = 217/681 (31%)

Query: 158 PKSGVCSCPSGLQPP-------------------------NCLQPCTP-----GYYGPAC 187
           P S  C CP G +PP                          C   C P     G      
Sbjct: 80  PPSTGCGCPPGTEPPVLASEVQALRVRLEILEELVKGLKEQCTGGCCPASAQAGTGQTDV 139

Query: 188 QFRCQCHGAPCDPQTGACFCPAERTGPSCD-------VSCSQGTSGFFCPSTHSCQNGGV 240
           +  C  HG   D     C C     GP+C           S  ++   CP    C + G 
Sbjct: 140 RTLCSLHGV-FDLSRCTCSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPD--DCNDQG- 195

Query: 241 FQTPQGSCSCPPGWMGTICSLP------------------CPEGFHGPNCSQEC---RCH 279
            +  +G C C PG+ G  C  P                  C  GF GP+CSQ      C 
Sbjct: 196 -RCVRGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQRSCPRGCS 254

Query: 280 NGGLCDRFTGQCRCAPGYTGDRC-REECPVGRFGQDCAETCDCAPDARCFPANGACLCEH 338
             G C+   G+C C PGYTGD C    CP G           C+   RC   NG C+C  
Sbjct: 255 QRGRCE--GGRCVCDPGYTGDDCGMRSCPRG-----------CSQRGRC--ENGRCVCNP 299

Query: 339 GFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHC-NESCPQ 397
           G+TG+ C  R CP G     C     C           +G C C PG+ G  C   SCP 
Sbjct: 300 GYTGEDCGVRSCPRG-----CSQRGRC----------KDGRCVCDPGYTGEDCGTRSCPW 344

Query: 398 DTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCAS-LCPPDTYGVNCSARCSCENA 456
           D           C  GG C    G C C PGYTG  C++  CP D     C  R  CE  
Sbjct: 345 D-----------CGEGGRC--VDGRCVCWPGYTGEDCSTRTCPRD-----CRGRGRCE-- 384

Query: 457 IACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWH 516
                 DGEC+C  G+   +C V   PG     CN   +C        + G C C PG+ 
Sbjct: 385 ------DGECICDTGYSGDDCGVRSCPG----DCNQRGRC--------EDGRCVCWPGYT 426

Query: 517 GAHC-QLPCPK-----------------GQFGEGCASRC---DCDHSDGCDPVHGRCQCQ 555
           G  C    CP+                 G  GE C  R    DC     C+   GRC C 
Sbjct: 427 GTDCGSRACPRDCRGRGRCENGVCVCNAGYSGEDCGVRSCPGDCRGRGRCE--SGRCMCW 484

Query: 556 AGWMGARCHL-SCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGR 614
            G+ G  C   +CP             C+  G C+  +G CVC PGF G  C        
Sbjct: 485 PGYTGRDCGTRACPG-----------DCRGRGRCV--DGRCVCNPGFTGEDC-------- 523

Query: 615 YGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQ------------------PCPPGH 656
            G R  P  C  H  C   +G C C AG++G DCS                    C  G+
Sbjct: 524 -GSRRCPGDCRGHGLC--EDGVCVCDAGYSGEDCSTRSCPGGCRGRGQCLDGRCVCEDGY 580

Query: 657 WGENC-AQTC--QCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPG 713
            GE+C  + C   C   G C  QDG CIC   W G +  E C + T  +NC    +C   
Sbjct: 581 SGEDCGVRQCPNDCSQHGVC--QDGVCIC---WEG-YVSEDCSIRTCPSNCHGRGRC--- 631

Query: 714 EKCHPETGACVCPPGHSGAPC 734
                E G C+C PG++G  C
Sbjct: 632 -----EEGRCLCDPGYTGPTC 647



 Score =  234 bits (596), Expect = 4e-61
 Identities = 221/719 (30%), Positives = 267/719 (37%), Gaps = 185/719 (25%)

Query: 44  SRPFSLLPSEPCERPWEGPHTC------PQPTVVYRTVY---RQVVKTDHRQRLQCCHGF 94
           SR    LP+ P   P  G HT       P   +   TV    +QVV T HR  L    G 
Sbjct: 28  SRSNVTLPA-PRPPPQPGGHTVGAGVGSPSSQLYEHTVEGGEKQVVFT-HRINLPPSTGC 85

Query: 95  YESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGP---QCDKPCSCG 151
               G   P+ A E    R       + V G + + C+  C P        Q D    C 
Sbjct: 86  GCPPGTEPPVLASEVQALRVRLEILEELVKGLK-EQCTGGCCPASAQAGTGQTDVRTLCS 144

Query: 152 NNSSCDPKSGVCSCPSGLQPPNC-------LQPCTPGYYGPACQFRCQCHGAPCDPQTGA 204
            +   D     CSC  G   P C       + P +P     +C   C   G       G 
Sbjct: 145 LHGVFDLSRCTCSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCV---RGR 201

Query: 205 CFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSL-PC 263
           C C    TGPSC            CP    CQ  G  +  QG C C  G+ G  CS   C
Sbjct: 202 CVCFPGYTGPSCGWPS--------CPG--DCQGRG--RCVQGVCVCRAGFSGPDCSQRSC 249

Query: 264 PEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRC-REECPVGRFGQDCAETCDCA 322
           P G     CSQ  RC  G        +C C PGYTGD C    CP G           C+
Sbjct: 250 PRG-----CSQRGRCEGG--------RCVCDPGYTGDDCGMRSCPRG-----------CS 285

Query: 323 PDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSC 382
              RC   NG C+C  G+TG+ C  R CP G     C     C           +G C C
Sbjct: 286 QRGRC--ENGRCVCNPGYTGEDCGVRSCPRG-----CSQRGRCK----------DGRCVC 328

Query: 383 LPGWAGLHCN-ESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCAS-LCPP 440
            PG+ G  C   SCP D           C  GG C    G C C PGYTG  C++  CP 
Sbjct: 329 DPGYTGEDCGTRSCPWD-----------CGEGGRC--VDGRCVCWPGYTGEDCSTRTCPR 375

Query: 441 DTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEA 500
           D     C  R  CE        DGEC+C  G+   +C V   PG     CN   +C    
Sbjct: 376 D-----CRGRGRCE--------DGECICDTGYSGDDCGVRSCPG----DCNQRGRC---- 414

Query: 501 VCSPQTGACTCTPGWHGAHC-QLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWM 559
               + G C C PG+ G  C    CP+   G G   RC+          +G C C AG+ 
Sbjct: 415 ----EDGRCVCWPGYTGTDCGSRACPRDCRGRG---RCE----------NGVCVCNAGYS 457

Query: 560 GARCHL-SCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKR 618
           G  C + SCP             C+  G C  E+G C+C PG+ G  C         G R
Sbjct: 458 GEDCGVRSCPGD-----------CRGRGRC--ESGRCMCWPGYTGRDC---------GTR 495

Query: 619 CVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDG 678
             P  C     C   +G C C  G+TG DC     PG           C   G C  +DG
Sbjct: 496 ACPGDCRGRGRC--VDGRCVCNPGFTGEDCGSRRCPG----------DCRGHGLC--EDG 541

Query: 679 SCICPLGWTGHHC-LEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRI 736
            C+C  G++G  C    CP G  G       QC  G         CVC  G+SG  C +
Sbjct: 542 VCVCDAGYSGEDCSTRSCPGGCRGRG-----QCLDGR--------CVCEDGYSGEDCGV 587



 Score =  140 bits (353), Expect = 6e-33
 Identities = 128/453 (28%), Positives = 163/453 (35%), Gaps = 119/453 (26%)

Query: 105 CAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMW---GPQCDKPCSCGNNSSCDPKSG 161
           C  +C  G      +C C PG+ G+DCS+   P      G   D  C C    S D   G
Sbjct: 342 CPWDCGEGGRCVDGRCVCWPGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDD-CG 400

Query: 162 VCSCPSGLQPPNCLQP----CTPGYYGPACQFRC---QCHG-APCDPQTGACFCPAERTG 213
           V SCP         +     C PGY G  C  R     C G   C+   G C C A  +G
Sbjct: 401 VRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSRACPRDCRGRGRCE--NGVCVCNAGYSG 458

Query: 214 PSCDVS------------------CSQGTSGFFCPSTHSCQNG--GVFQTPQGSCSCPPG 253
             C V                   C  G +G  C  T +C     G  +   G C C PG
Sbjct: 459 EDCGVRSCPGDCRGRGRCESGRCMCWPGYTGRDC-GTRACPGDCRGRGRCVDGRCVCNPG 517

Query: 254 WMGTICS------------------LPCPEGFHGPNCS-QECR--CHNGGLCDRFTGQCR 292
           + G  C                     C  G+ G +CS + C   C   G C    G+C 
Sbjct: 518 FTGEDCGSRRCPGDCRGHGLCEDGVCVCDAGYSGEDCSTRSCPGGCRGRGQC--LDGRCV 575

Query: 293 CAPGYTGDRCR-EECP-----------------VGRFGQDCA-ETC--DCAPDARCFPAN 331
           C  GY+G+ C   +CP                  G   +DC+  TC  +C    RC    
Sbjct: 576 CEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGRC--EE 633

Query: 332 GACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHC 391
           G CLC+ G+TG  C  R+CP       C+    C          + G C C  G+ G  C
Sbjct: 634 GRCLCDPGYTGPTCATRMCP-----ADCRGRGRC----------VQGVCLCHVGYGGEDC 678

Query: 392 NESCPQDTHGP-GCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCA-SLCPPDTYGVNCSA 449
            +  P  +  P GC    LC         +G C C  G+ GP CA   CP D     C  
Sbjct: 679 GQEEPPASACPGGCGPRELC--------RAGQCVCVEGFRGPDCAIQTCPGD-----CRG 725

Query: 450 RCSCENAIACSPIDGECVCKEGWQRGNCSVPCP 482
           R  C         DG CVCK+G+   +C    P
Sbjct: 726 RGECH--------DGSCVCKDGYAGEDCGEEVP 750



 Score =  119 bits (299), Expect = 1e-26
 Identities = 105/374 (28%), Positives = 133/374 (35%), Gaps = 100/374 (26%)

Query: 91  CHGFYESRGFCVPLCAQECV-HGRCVAPNQCQCVPGWRGDDCSSE--------------- 134
           C+  Y      V  C  +C   GRC +  +C C PG+ G DC +                
Sbjct: 452 CNAGYSGEDCGVRSCPGDCRGRGRCES-GRCMCWPGYTGRDCGTRACPGDCRGRGRCVDG 510

Query: 135 ---CAPGMWGPQCDK---PCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQ 188
              C PG  G  C     P  C  +  C+   GVC C +G    +C     PG     C+
Sbjct: 511 RCVCNPGFTGEDCGSRRCPGDCRGHGLCE--DGVCVCDAGYSGEDCSTRSCPG----GCR 564

Query: 189 FRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSC 248
            R QC         G C C    +G  C V          CP  + C   GV Q   G C
Sbjct: 565 GRGQC-------LDGRCVCEDGYSGEDCGVR--------QCP--NDCSQHGVCQ--DGVC 605

Query: 249 SCPPGWMGTICSL-PCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREE-C 306
            C  G++   CS+  CP             CH  G C+   G+C C PGYTG  C    C
Sbjct: 606 ICWEGYVSEDCSIRTCPS-----------NCHGRGRCEE--GRCLCDPGYTGPTCATRMC 652

Query: 307 PVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCD 366
           P            DC    RC    G CLC  G+ G+ C     P      +C   C   
Sbjct: 653 P-----------ADCRGRGRC--VQGVCLCHVGYGGEDCGQEEPP----ASACPGGCG-P 694

Query: 367 REHSLSCHPMNGECSCLPGWAGLHCN-ESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQC 425
           RE   +     G+C C+ G+ G  C  ++CP D  G G             +   G C C
Sbjct: 695 RELCRA-----GQCVCVEGFRGPDCAIQTCPGDCRGRG-------------ECHDGSCVC 736

Query: 426 APGYTGPHCASLCP 439
             GY G  C    P
Sbjct: 737 KDGYAGEDCGEEVP 750


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score =  250 bits (639), Expect = 4e-66
 Identities = 233/792 (29%), Positives = 284/792 (35%), Gaps = 227/792 (28%)

Query: 103 PLCAQECVHG-RC-VAPNQ---CQCVPGWRGDDCSS---ECAPGMWGPQCDKPCSCGNNS 154
           P  +  C HG RC V P+    C C PG++G  C S   EC  G       +PC  G   
Sbjct: 122 PCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVG-------EPCRHGGTC 174

Query: 155 SCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGP 214
              P S  C CP+G   P C  P  P    P C+    C  +     T  C C     G 
Sbjct: 175 LNTPGSFRCQCPAGYTGPLCENPAVPCAPSP-CRNGGTCRQS--GDLTYDCACLPGFEGQ 231

Query: 215 SCDVSCSQGTSGFFCPSTHSCQNGG--VFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNC 272
           +C+V+         CP  H C NGG  V      +C CPP W G  C+    E    PN 
Sbjct: 232 NCEVNVDD------CPG-HRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNA 284

Query: 273 SQECRCHNGGLCDRFTG--QCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFP- 329
                CHNGG C    G   C C  G+TG+ C +         DCA T  C   A C   
Sbjct: 285 -----CHNGGTCFNTLGGHSCVCVNGWTGESCSQNI------DDCA-TAVCFHGATCHDR 332

Query: 330 -ANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGE--CSCLPGW 386
            A+  C C  G TG  C      D      C     CD       +P+NG   C+C PG+
Sbjct: 333 VASFYCACPMGKTGLLCH---LDDACVSNPCHEDAICD------TNPVNGRAICTCPPGF 383

Query: 387 AGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSG--LCQCAPGYTGPHCASLCPPDTYG 444
            G  C++   + + G        C H G C  T G  LCQC  GYTGP C +        
Sbjct: 384 TGGACDQDVDECSIGAN-----PCEHLGRCVNTQGSFLCQCGRGYTGPRCET-------D 431

Query: 445 VNCSARCSCENAIACSPIDGE--CVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVC 502
           VN      C N   C    G+  C+C  G+    C V          C +S  C +  VC
Sbjct: 432 VNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDID------ECQSS-PCVNGGVC 484

Query: 503 SPQTG--ACTCTPGWHGAHCQL--------PCPKG----QFGEGCASRCD-------CDH 541
             +    +CTC  G+ G+ CQL        PC  G       +G   RC        CD 
Sbjct: 485 KDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDR 544

Query: 542 S-DGCDP---VHGR---------CQCQAGWMGARCH------------------------ 564
           + D C P    HGR         C C  G+ G RC                         
Sbjct: 545 NVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKY 604

Query: 565 -LSCPEGLWGVNC--------SNTCT---CKNGGTCLPENGNCVCAPGFRGPSCQ----- 607
              CP G  GVNC        SN CT   C++G        +CVC PGF GP C      
Sbjct: 605 LCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDG----INRYDCVCQPGFTGPLCNVEINE 660

Query: 608 ---------RSCQPGRYGKRCV---------------PC--KCANHSFCH--PSNGTCYC 639
                     SC  G  G RC+               PC  +  +H  C+  P    C C
Sbjct: 661 CASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVC 720

Query: 640 LAGWTGPDCSQ---------------------------PCPPGHWGENC--AQTC---QC 667
             GW+GP CSQ                            CPPG  G  C     C    C
Sbjct: 721 EPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPC 780

Query: 668 HHGGTCHPQDGS---CICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETG--A 722
            HGG C    G    C CP GW G  C +          C+ P  CGP   C    G  +
Sbjct: 781 EHGGRCESAPGQLPVCSCPQGWQGPRCQQDVD------ECAGPAPCGPHGICTNLAGSFS 834

Query: 723 CVCPPGHSGAPC 734
           C C  G++G  C
Sbjct: 835 CTCHGGYTGPSC 846



 Score =  241 bits (615), Expect = 3e-63
 Identities = 211/701 (30%), Positives = 256/701 (36%), Gaps = 144/701 (20%)

Query: 105  CAQE-CVHGRCV-APN--QCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKS 160
            CA E C HG C  AP   +C C PGW G  CS   A      Q   PC  G   S D   
Sbjct: 699  CAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQ---PCRAGGTCSSDGMG 755

Query: 161  GVCSCPSGLQPPNC--LQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDV 218
              C+CP G+Q   C  L PCTP      C+   +C  AP   Q   C CP    GP C  
Sbjct: 756  FHCTCPPGVQGRQCELLSPCTPN----PCEHGGRCESAP--GQLPVCSCPQGWQGPRCQQ 809

Query: 219  SCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECR- 277
               +      C     C   G+     GS SC            C  G+ GP+C Q+   
Sbjct: 810  DVDE------CAGPAPCGPHGICTNLAGSFSCT-----------CHGGYTGPSCDQDIND 852

Query: 278  -----CHNGGLCDRFTGQ--CRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARC-FP 329
                 C NGG C    G   C C PG+ G RC  +        +C     C P       
Sbjct: 853  CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDV------DECLSN-PCGPGTCTDHV 905

Query: 330  ANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTC-DREHSLSCHPMNGECSCLPGWAG 388
            A+  C C  G+ G  C   L PD     SC    TC D  +S SC        C PG+ G
Sbjct: 906  ASFTCTCPPGYGGFHCEQDL-PDCSPS-SCFNGGTCVDGVNSFSC-------LCRPGYTG 956

Query: 389  LHCNESCPQDTHGPGCQEHCLCLHGGVCQATSG--LCQCAPGYTGPHCASLCPPDTYGVN 446
             HC          P       CLHGGVC A      C C   +TGP C +L       V+
Sbjct: 957  AHCQHEADPCLSRP-------CLHGGVCSAAHPGFRCTCLESFTGPQCQTL-------VD 1002

Query: 447  CSARCSCENAIACSPIDGECVCKEGWQRGNC---SVPCPPGTW--GFSCNASCQCAHEAV 501
              +R  C+N   C      C+C  GW    C   S+PC       G      CQ   + V
Sbjct: 1003 WCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCV 1062

Query: 502  CSPQTGACTCTPGWHGAHCQL--------PCPKGQFGEGCAS--RCDC---DHSDGCDPV 548
                +  C C  G  G+HC+         PC  G    G      C+C    + D C+  
Sbjct: 1063 DEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDD 1122

Query: 549  HGRCQ---CQAGW----MGARCHLSCPEGLWGVNCS---NTC----------TCKNGGTC 588
               C    CQ G     + AR   SCP G  GV C    + C           C + GTC
Sbjct: 1123 VDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTC 1182

Query: 589  LPENGN--CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC--HPSNG-TCYCLAGW 643
            +   G   C C PG+ G  C+      R G     C  A+   C   P  G  C C AG+
Sbjct: 1183 VDLVGGFRCTCPPGYTGLRCEADINECRSGA----CHAAHTRDCLQDPGGGFRCLCHAGF 1238

Query: 644  TGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDG-------SCICPLGWTGHHCLEGCP 696
            +GP C     P        ++  C HGG C P  G       +C C   + G  C     
Sbjct: 1239 SGPRCQTVLSP-------CESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERV-- 1289

Query: 697  LGTFGANCSQPCQCGPGEKCH--PETGACVCPPGHSGAPCR 735
                 A   +  QC  G  C   P    C CPPG SG  CR
Sbjct: 1290 -----ARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCR 1325



 Score =  216 bits (551), Expect = 7e-56
 Identities = 217/781 (27%), Positives = 277/781 (35%), Gaps = 197/781 (25%)

Query: 90   CCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCS 149
            C  GF    G    L   EC    C   N  +CV    G +C   CA G  G  CD+   
Sbjct: 495  CPSGF---SGSTCQLDVDECASTPC--RNGAKCVDQPDGYEC--RCAEGFEGTLCDR--- 544

Query: 150  CGNNSSCDPKSGVCS---CPSGLQPPNCLQPCTPGYYGPACQFRC-QCHGAPCDP----- 200
              N   C P    C    C  G+   +C   C PGY G  C+ +  +C   PC       
Sbjct: 545  --NVDDCSPDP--CHHGRCVDGIASFSCA--CAPGYTGTRCESQVDECRSQPCRHGGKCL 598

Query: 201  ---QTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGT 257
                   C CP+  TG +C+V+     S    P T      G+ +     C C PG+ G 
Sbjct: 599  DLVDKYLCRCPSGTTGVNCEVNIDDCASN---PCTFGVCRDGINRY---DCVCQPGFTGP 652

Query: 258  ICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDC-- 315
            +C++   E    P       C  GG          C  G  G RC   CP G     C  
Sbjct: 653  LCNVEINECASSP-------CGEGG---------SCVDGENGFRCL--CPPGSLPPLCLP 694

Query: 316  -AETCDCAPDAR--CFPANGA--CLCEHGFTGDRCTDRL--------------------- 349
             +  C   P +   C+ A G   C+CE G++G RC+  L                     
Sbjct: 695  PSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGM 754

Query: 350  -----CPDGFYGLSCQ--APCTCDR-EHSLSCHPMNGE---CSCLPGWAGLHCNESCPQD 398
                 CP G  G  C+  +PCT +  EH   C    G+   CSC  GW G  C +   + 
Sbjct: 755  GFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDEC 814

Query: 399  THGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHC---ASLCPPD--TYGVNC-----S 448
                 C  H +C +     A S  C C  GYTGP C    + C P+    G +C     S
Sbjct: 815  AGPAPCGPHGICTN----LAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGS 870

Query: 449  ARCSCENAIA---CSPIDGECV--------CKEGWQRGNCSVPCPPGTWGFSCN------ 491
              CSC    A   C+    EC+        C +      C+  CPPG  GF C       
Sbjct: 871  FSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCT--CPPGYGGFHCEQDLPDC 928

Query: 492  --ASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVH 549
              +SC      V    + +C C PG+ GAHCQ         + C SR  C H   C   H
Sbjct: 929  SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ------HEADPCLSR-PCLHGGVCSAAH 981

Query: 550  G--RCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQ 607
               RC C   + G +C          V+  +   C+NGG C+     C+C PG+ G  C 
Sbjct: 982  PGFRCTCLESFTGPQCQTL-------VDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCD 1034

Query: 608  RSCQPGRYGKRCVP------CKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENC 661
                P R     +       C+         S+  C C  G TG  C Q   P       
Sbjct: 1035 IRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDP-----CL 1089

Query: 662  AQTCQCHHGGTCHPQDGS--CICPLGWTGHHC-------------------------LEG 694
            AQ CQ  HGGTC    G   C C  G+ G +C                         L  
Sbjct: 1090 AQPCQ--HGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCS 1147

Query: 695  CPLGTFGANCS-QPCQCGPGE------------KCHPETGA--CVCPPGHSGAPCRIGIQ 739
            CP GT G  C      CGPG              C    G   C CPPG++G  C   I 
Sbjct: 1148 CPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADIN 1207

Query: 740  E 740
            E
Sbjct: 1208 E 1208



 Score =  187 bits (475), Expect = 4e-47
 Identities = 195/681 (28%), Positives = 231/681 (33%), Gaps = 179/681 (26%)

Query: 99   GFCVPLCAQ---ECVHGRC--------VAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKP 147
            GF  P CA+   EC+   C        VA   C C PG+ G  C  +       P C  P
Sbjct: 878  GFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDL------PDCS-P 930

Query: 148  CSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQ-------CHGAPCDP 200
             SC N  +C           G+   +CL  C PGY G  CQ            HG  C  
Sbjct: 931  SSCFNGGTC---------VDGVNSFSCL--CRPGYTGAHCQHEADPCLSRPCLHGGVCSA 979

Query: 201  QTGA--CFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTI 258
                  C C    TGP C           +C S   CQNGG        C CPPGW G +
Sbjct: 980  AHPGFRCTCLESFTGPQCQTLVD------WC-SRQPCQNGGRCVQTGAYCLCPPGWSGRL 1032

Query: 259  C---SLP--------------------------------CPEGFHGPNCSQEC------R 277
            C   SLP                                CPEG  G +C QE        
Sbjct: 1033 CDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQP 1092

Query: 278  CHNGGLCDRFTG--QCRCAPGYTGDRCREE-------------------------CPVGR 310
            C +GG C  + G   C C PGY GD C ++                         CP G 
Sbjct: 1093 CQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGT 1152

Query: 311  FGQDC-AETCDCAP------DARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPC 363
             G  C     DC P        RC   NG C+   G  G RCT   CP G+ GL C+A  
Sbjct: 1153 LGVLCEINEDDCGPGPPLDSGPRCL-HNGTCVDLVG--GFRCT---CPPGYTGLRCEADI 1206

Query: 364  TCDREHSLSCHPMN-GECSCLPGWAGLHCNESCPQDTHGPGCQ------EHCLCLHGGVC 416
               R  S +CH  +  +C   PG  G  C   C     GP CQ      E   C HGG C
Sbjct: 1207 NECR--SGACHAAHTRDCLQDPG-GGFRC--LCHAGFSGPRCQTVLSPCESQPCQHGGQC 1261

Query: 417  QATSG-------LCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCK 469
            + + G        C CA  + GP C  +       + C     C+     +P    C C 
Sbjct: 1262 RPSPGPGGGLTFTCHCAQPFWGPRCERVA-RSCRELQCPVGVPCQQ----TPRGPRCACP 1316

Query: 470  EGWQRGNC-SVP-CPPGTWGFSCNASCQCAHEAVCSPQTGA----CTCTPGWHGAHCQLP 523
             G    +C S P  PPG    SC A+  C H   C P   A    C C  GW G  C+ P
Sbjct: 1317 PGLSGPSCRSFPGSPPGASNASC-AAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAP 1375

Query: 524  CPKGQFG-EGCASRCDCDHSDGCDPVHGRCQCQ-AGWMGARCHLSCPEGLWGVNCSNTCT 581
                +   E    R  C    G       C     GW G  C LS  +  W       C 
Sbjct: 1376 AAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDP-W-----RQCE 1429

Query: 582  CKNGGTCLPENGNCVCAPGFRGPSC---QRSCQPGRYGKRCVPC---KCANH---SFCHP 632
                  C     N  C P    P+C      C  G   + C P     CA+H     C  
Sbjct: 1430 ALQ---CWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQ 1486

Query: 633  SNGTCYCLAGWTGPDCSQPCP 653
               T  C  GW G DC+   P
Sbjct: 1487 GCNTEEC--GWDGLDCASEVP 1505



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 57/183 (31%), Positives = 69/183 (37%), Gaps = 30/183 (16%)

Query: 576 CSNTCTCKNGGTC--LPEN-GNCVCAPGFRGPSCQRS--CQPGRYGKRCVPCKCANHSFC 630
           C +   C NGG C  LP     C+C PG+ G  CQ    C  G    R V   C +    
Sbjct: 43  CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGV---CQSSVVA 99

Query: 631 HPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHP-QDGSCICPLGWTGH 689
             +  +C C  G+ GPDCS P P          +  C HG  C    DG  +C       
Sbjct: 100 GTARFSCRCPRGFRGPDCSLPDP--------CLSSPCAHGARCSVGPDGRFLC------- 144

Query: 690 HCLEGCPLGTFGANC-SQPCQCGPGEKCHPETGACVCPPGHSGAPCRIGIQEPFTVMPTT 748
                CP G  G +C S   +C  GE C    G C+  PG     C  G   P    P  
Sbjct: 145 ----SCPPGYQGRSCRSDVDECRVGEPCR-HGGTCLNTPGSFRCQCPAGYTGPLCENPAV 199

Query: 749 PVA 751
           P A
Sbjct: 200 PCA 202


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score =  246 bits (629), Expect = 6e-65
 Identities = 256/943 (27%), Positives = 314/943 (33%), Gaps = 300/943 (31%)

Query: 53   EPCERPWEGPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHGFY----ESRGFCVPLCAQE 108
            E C+   E P  CP      R   R  ++   R +  C  G+     + R FC    A  
Sbjct: 112  ERCQAKLEDP--CPPSFCSKRG--RCHIQASGRPQCSCMPGWTGEQCQLRDFC---SANP 164

Query: 109  CVHGR-CVAPN---QCQCVPGWRGDDCSSECAPGMWGP-QCDKPCSCGNNSSCDPKSGVC 163
            CV+G  C+A     QC C PG+ G  C  +       P  C K  SC N       S  C
Sbjct: 165  CVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLG----SFQC 220

Query: 164  SCPSGLQPPNC-------------------LQP----------CTPGYYGPACQFR---C 191
             CP G + P C                   L P          C PG+ GP C+     C
Sbjct: 221  LCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNC 280

Query: 192  QCH----GAPCDP--QTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQ 245
              H    G  C     T  C CP   TG      CS+            C+NGG  Q   
Sbjct: 281  VSHQCQNGGTCQDGLDTYTCLCPETWTG----WDCSEDVDECETQGPPHCRNGGTCQNSA 336

Query: 246  GS--CSCPPGWMGTIC-------------------------SLPCPEGFHGPNCSQECRC 278
            GS  C C  GW GT C                         S  CP G  G  C  E  C
Sbjct: 337  GSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMC 396

Query: 279  -----HNGGLCDR--FTGQ--CRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFP 329
                 H    C     TG   C C PGY+G  C ++       Q     C+        P
Sbjct: 397  LSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTP 456

Query: 330  ANGACLCEHGFTGDRCTDR------------------------LCPDGFYGLSCQ----- 360
             +  CLC  G+TG RC                           LCP G  G  C+     
Sbjct: 457  GSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNE 516

Query: 361  ---APCTCDREHSLSCHPM-NG-ECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGV 415
               APC     +   CH + NG +C CLPG++G  C E   +    P       C +GG 
Sbjct: 517  CASAPCL----NHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSP-------CANGGQ 565

Query: 416  CQATSGL--CQCAPGYTGPHCAS-------------------------LCPPDTYGVNCS 448
            CQ   G   C+C PG+ GP C +                         LCP    G  C 
Sbjct: 566  CQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCE 625

Query: 449  ---------------------ARCSC-ENAIACSPIDGECVCKEGW-QRGNCSVPCPPGT 485
                                 A C C + +  C+P +  C C  G  QR +C   C  G 
Sbjct: 626  VPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCV--CDVGW 683

Query: 486  WGFSCNA------SCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDC 539
             G  C A      S  CAH   C PQ     CT           CP G  G  C+     
Sbjct: 684  TGPECEAELGGCISAPCAHGGTCYPQPSGYNCT-----------CPTGYTGPTCSEEMTA 732

Query: 540  DHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNT------CTCKNGGTCLPENG 593
             HS  C    G C    G  G  C  +CP    G  C  +        C NGGTC+   G
Sbjct: 733  CHSGPCLN-GGSCNPSPG--GYYC--TCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPG 787

Query: 594  --NCVCAPGFRGPSCQ---------------RSCQPGRYGKRCV---------------- 620
              +C+CA GF+GP C+                +CQ    G RC+                
Sbjct: 788  TFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDL 847

Query: 621  ----PCKCANHSFCHPSNGTCYCLAGWTGPDCSQP---CPPGHWGENCAQTCQCHHGGTC 673
                PC   +H      +  C CL GWTGP C+ P   C      +    +  CH+GG C
Sbjct: 848  CAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLC 907

Query: 674  HPQDGS--CICPLGWTGHHC------LEGCPLGTFGANC-SQP----CQCGPG------- 713
                 S  C CP G+ G  C       E  P    GA C +QP    CQC PG       
Sbjct: 908  VDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQN-GATCMAQPSGYLCQCAPGYDGQNCS 966

Query: 714  --------EKCH------PETGA--CVCPPGHSGAPCRIGIQE 740
                    + CH      P+ G   C CPPG  G  C   + E
Sbjct: 967  KELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDE 1009



 Score =  241 bits (615), Expect = 3e-63
 Identities = 218/774 (28%), Positives = 265/774 (34%), Gaps = 222/774 (28%)

Query: 120  CQCVPGWRG-------DDC------------------SSECAPGMWGPQC-------DKP 147
            C CV GW G       DDC                  S  C PG  G  C        +P
Sbjct: 341  CVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQP 400

Query: 148  CSCGNNSSCDPKSG--VCSCPSGLQPPNC---LQPCTPGYYGPACQFRCQCHGAPC--DP 200
            C      S +P +G  +C C  G   P C   L  C     GP+    C+ HG  C   P
Sbjct: 401  CHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPS---PCE-HGGSCLNTP 456

Query: 201  QTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICS 260
             +  C CP   TG  C+   ++  S    P +        F      C CPPG  G +C 
Sbjct: 457  GSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFH-----CLCPPGLEGQLCE 511

Query: 261  LP-------------------------CPEGFHGPNCSQ---ECR---CHNGGLCDRFTG 289
            +                          C  GF G  C +   ECR   C NGG C    G
Sbjct: 512  VETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPG 571

Query: 290  --QCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGA--CLCEHGFTGDRC 345
               C+C PG+ G RC+ E        +C     C   A C    GA  CLC  GFTG  C
Sbjct: 572  AFHCKCLPGFEGPRCQTEV------DECLSD-PCPVGASCLDLPGAFFCLCPSGFTGQLC 624

Query: 346  ----------------------TDRLCPDGFYGLSCQAP---CTCDREHSLSCHPMNGEC 380
                                   + LCPDG  G  C  P   CTC   H          C
Sbjct: 625  EVPLCAPNLCQPKQICKDQKDKANCLCPDGSPG--CAPPEDNCTCHHGHC-----QRSSC 677

Query: 381  SCLPGWAGLHC-------------------------NESCPQDTHGPGCQEHCL------ 409
             C  GW G  C                         N +CP    GP C E         
Sbjct: 678  VCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGP 737

Query: 410  CLHGGVCQATSG--LCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDG--E 465
            CL+GG C  + G   C C P +TGP C +         +      C N   C    G   
Sbjct: 738  CLNGGSCNPSPGGYYCTCPPSHTGPQCQT-------STDYCVSAPCFNGGTCVNRPGTFS 790

Query: 466  CVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVC--SPQTGACTCTPGWHGAHCQL- 522
            C+C  G+Q   C     P     SC A   C + A C  SPQ   C C  G+ G  CQ  
Sbjct: 791  CLCAMGFQGPRCEGKLRP-----SC-ADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTL 844

Query: 523  -------PCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHL---SCPEGLW 572
                   PCP+      C       H          C C  GW G  C+L   SC +   
Sbjct: 845  MDLCAQKPCPRNSH---CLQTGPSFH----------CLCLQGWTGPLCNLPLSSCQKAAL 891

Query: 573  GVNCSNTCTCKNGGTCLPENGN--CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC 630
                  +  C NGG C+    +  C C PGF+G  CQ    P      C    C N + C
Sbjct: 892  SQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNP------CESRPCQNGATC 945

Query: 631  --HPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGS--CICPLGW 686
               PS   C C  G+ G +CS+         +  Q+  CH+ GTC P+ G   C CP G+
Sbjct: 946  MAQPSGYLCQCAPGYDGQNCSKEL-------DACQSQPCHNHGTCTPKPGGFHCACPPGF 998

Query: 687  TGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGA--CVCPPGHSGAPCRIGI 738
             G  C      G       QPC       CH    A  C C PGH+G  C + I
Sbjct: 999  VGLRCE-----GDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEI 1047



 Score =  239 bits (609), Expect = 1e-62
 Identities = 227/807 (28%), Positives = 287/807 (35%), Gaps = 214/807 (26%)

Query: 88  LQCCHGFYESRGFCVPLCAQECVHG-RCVA----PNQCQCVPGWRGDDCSSECAPGMWGP 142
           L  C      RG       + C +G  C++       CQC PG+ G+ C        +  
Sbjct: 14  LLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETC-------QFPD 66

Query: 143 QCDKPCSCGNNSSCD----PKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPC 198
            C     C N  SC        G+ S PS L  P+ L  C PG+ G  CQ + +    PC
Sbjct: 67  PCQNAQLCQNGGSCQALLPAPLGLPSSPSPL-TPSFLCTCLPGFTGERCQAKLE---DPC 122

Query: 199 DP----QTGACFCPAERTGPSCDVSCSQGTSGFFCP-----STHSCQNGGVFQT--PQGS 247
            P    + G C   A    P C  SC  G +G  C      S + C NGGV     PQ  
Sbjct: 123 PPSFCSKRGRCHIQASGR-PQC--SCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQ 179

Query: 248 CSCPPGWMGTICSLPCPEGFHGPN-CSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREEC 306
           C CPPG+ G  C     E F  P  C +   CHN       + QC C  G  G RC    
Sbjct: 180 CHCPPGFEGHACERDVNECFQDPGPCPKGTSCHN----TLGSFQCLCPVGQEGPRCELRA 235

Query: 307 -PVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTC 365
            P    G     TC   P+         CLC  GF G  C   + PD      CQ   TC
Sbjct: 236 GPCPPRGCSNGGTCQLMPEKD--STFHLCLCPPGFIGPDC--EVNPDNCVSHQCQNGGTC 291

Query: 366 DREHSLSCHPMNGECSCLPGWAGLHCNESCPQ-DTHGPGCQEHCLCLHGGVCQATSGL-- 422
             +  L  +     C C   W G  C+E   + +T GP    H  C +GG CQ ++G   
Sbjct: 292 --QDGLDTY----TCLCPETWTGWDCSEDVDECETQGP---PH--CRNGGTCQNSAGSFH 340

Query: 423 CQCAPGYTGPHC-------------------------ASLCPPDTYGVNCSARCSCENAI 457
           C C  G+ G  C                         + LCPP   G+     C  E+  
Sbjct: 341 CVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGL----LCHLEDMC 396

Query: 458 ACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQ-----------CAHEAVC--SP 504
              P  G+  C      G+    C PG  G +C+               C H   C  +P
Sbjct: 397 LSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTP 456

Query: 505 QTGACTCTPGWHGAHCQLP-------------------------CPKGQFGE-------G 532
            +  C C PG+ G+ C+                           CP G  G+        
Sbjct: 457 GSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNE 516

Query: 533 CASRCDCDHSDGCDPVHG-RCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPE 591
           CAS    +H+D  D ++G +C C  G+ G RC     E         +  C NGG C  +
Sbjct: 517 CASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDE-------CRSSPCANGGQCQDQ 569

Query: 592 NG--NCVCAPGFRGPSCQRSCQPGRYGKRCV--PCKCANHSFCHPSNGTCYCLAGWTGPD 647
            G  +C C PGF GP CQ           C+  PC         P    C C +G+TG  
Sbjct: 570 PGAFHCKCLPGFEGPRCQTEVD------ECLSDPCPVGASCLDLPGAFFCLCPSGFTGQL 623

Query: 648 CSQP-----------------------CPPGHWGENCA---QTCQCHHGGTCHPQDGSCI 681
           C  P                       CP G  G  CA     C CHHG   H Q  SC+
Sbjct: 624 CEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPG--CAPPEDNCTCHHG---HCQRSSCV 678

Query: 682 CPLGWTGHHC---LEG----------------------CPLGTFGANCSQ---PCQCGP- 712
           C +GWTG  C   L G                      CP G  G  CS+    C  GP 
Sbjct: 679 CDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPC 738

Query: 713 --GEKCHPETGA--CVCPPGHSGAPCR 735
             G  C+P  G   C CPP H+G  C+
Sbjct: 739 LNGGSCNPSPGGYYCTCPPSHTGPQCQ 765



 Score =  214 bits (544), Expect = 4e-55
 Identities = 217/775 (28%), Positives = 260/775 (33%), Gaps = 213/775 (27%)

Query: 99   GFCVPLCAQ---ECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDK--------P 147
            GF    C +   EC    C    QCQ  PG        +C PG  GP+C          P
Sbjct: 542  GFSGTRCEEDIDECRSSPCANGGQCQDQPG----AFHCKCLPGFEGPRCQTEVDECLSDP 597

Query: 148  CSCGNNSSCDPKSGVCSCPSG---------LQPPNCLQP--------------CTPGYYG 184
            C  G +    P +  C CPSG         L  PN  QP              C  G   
Sbjct: 598  CPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDG--S 655

Query: 185  PAC---QFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVF 241
            P C   +  C CH   C  Q  +C C    TGP C+           C S      G  +
Sbjct: 656  PGCAPPEDNCTCHHGHC--QRSSCVCDVGWTGPECEAELGG------CISAPCAHGGTCY 707

Query: 242  QTPQG-SCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTG--QCRCAPGYT 298
              P G +C+CP G+ G  CS        GP       C NGG C+   G   C C P +T
Sbjct: 708  PQPSGYNCTCPTGYTGPTCSEEMTACHSGP-------CLNGGSCNPSPGGYYCTCPPSHT 760

Query: 299  GDRCREECPVGRFGQDCAETCDCAPDARCF--PANGACLCEHGFTGDRCTDRL------- 349
            G +C+          D   +  C     C   P   +CLC  GF G RC  +L       
Sbjct: 761  GPQCQTST-------DYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADS 813

Query: 350  ------------------CPDGFYGLSCQ------APCTCDRE-HSLSCHPMNGECSCLP 384
                              CP G+ G SCQ      A   C R  H L   P +  C CL 
Sbjct: 814  PCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGP-SFHCLCLQ 872

Query: 385  GWAGLHCNES-----------------------------------CPQDTHGPGCQEHCL 409
            GW G  CN                                     CP    G  CQ+H  
Sbjct: 873  GWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVN 932

Query: 410  ------CLHGGVCQATSG--LCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSP 461
                  C +G  C A     LCQCAPGY G +C+         ++      C N   C+P
Sbjct: 933  PCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSK-------ELDACQSQPCHNHGTCTP 985

Query: 462  IDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQ 521
              G   C            CPPG  G  C        +  C P TG   C    +  +CQ
Sbjct: 986  KPGGFHC-----------ACPPGFVGLRCEGDVDECLDQPCHP-TGTAACHSLANAFYCQ 1033

Query: 522  LPCPKGQFGEGCASRCDCDHSDGCDPVH-GRCQCQAGW-MGARCHLSCPEGLWGVNCSNT 579
              C  G  G+ C    D  HS  C   H G C+  AG  +G  CH  CP+G  G  CS+ 
Sbjct: 1034 --CLPGHTGQWCEVEIDPCHSQPC--FHGGTCEATAGSPLGFICH--CPKGFEGPTCSHR 1087

Query: 580  CT------CKNGGTCLPE-----NGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHS 628
                    C +GG CLP         C C  G+ GP C     P   G    P  C    
Sbjct: 1088 APSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGP---PSPCL--- 1141

Query: 629  FCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENC----AQTCQCHHG-GTCHPQDGSCICP 683
                 NG+C    G  GP     CP    G  C    A+ C+   G G C   D  C  P
Sbjct: 1142 ----YNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGAC---DAGCSGP 1194

Query: 684  LG-WTGHHCLEGCPLGTFGANCSQPC-------QCGP---GEKCHPETGACVCPP 727
             G W G  C  G P    G      C       QC P    E+C  +   C  PP
Sbjct: 1195 GGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPP 1249



 Score =  202 bits (513), Expect = 2e-51
 Identities = 197/750 (26%), Positives = 248/750 (33%), Gaps = 197/750 (26%)

Query: 47   FSLLPS----EPCERPWEGPHTCPQPTVVYRTVYRQVVKTDHRQRLQC-CHGFYESRGFC 101
            F L PS    + CE P   P+ C QP        +Q+ K D + +  C C     S G  
Sbjct: 612  FCLCPSGFTGQLCEVPLCAPNLC-QP--------KQICK-DQKDKANCLCPD--GSPGCA 659

Query: 102  VPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSE-------------------------CA 136
             P     C HG C   + C C  GW G +C +E                         C 
Sbjct: 660  PPEDNCTCHHGHCQR-SSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCP 718

Query: 137  PGMWGPQCDKPCS------CGNNSSCDPKSG--VCSCPSGLQPPNCLQP----------- 177
             G  GP C +  +      C N  SC+P  G   C+CP     P C              
Sbjct: 719  TGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFN 778

Query: 178  --------------CTPGYYGPACQ--FRCQCHGAPC--------DPQTGACFCPAERTG 213
                          C  G+ GP C+   R  C  +PC         PQ   C CP   TG
Sbjct: 779  GGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTG 838

Query: 214  PSCDVS---CSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLP---CPEGF 267
             SC      C+Q      CP    C   G    P   C C  GW G +C+LP   C +  
Sbjct: 839  GSCQTLMDLCAQKP----CPRNSHCLQTG----PSFHCLCLQGWTGPLCNLPLSSCQKAA 890

Query: 268  HGPNCSQECRCHNGGLCDRFTGQ--CRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDA 325
                      CHNGGLC        C C PG+ G  C++         +  E+  C   A
Sbjct: 891  LSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHV-------NPCESRPCQNGA 943

Query: 326  RCF--PANGACLCEHGFTGDRCTDRL------------------------CPDGFYGLSC 359
             C   P+   C C  G+ G  C+  L                        CP GF GL C
Sbjct: 944  TCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRC 1003

Query: 360  QAPCT------CDREHSLSCHPMNGE--CSCLPGWAGLHCNESCPQDTHGPGCQEHCLCL 411
            +          C    + +CH +     C CLPG  G  C          P       C 
Sbjct: 1004 EGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQP-------CF 1056

Query: 412  HGGVCQATSG-----LCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSP----- 461
            HGG C+AT+G     +C C  G+ GP C+   P      +C     C +   C P     
Sbjct: 1057 HGGTCEATAGSPLGFICHCPKGFEGPTCSHRAP------SCGFH-HCHHGGLCLPSPKPG 1109

Query: 462  IDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGA------CTCTPGW 515
                C C  G+   +C  P  P      C     C +   CS  TG       C+C    
Sbjct: 1110 FPPRCACLSGYGGPDCLTPPAPK----GCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSS 1165

Query: 516  HGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVN 575
             G  CQ P  KG  G      CD     GC    G       W G  C L  P+   G  
Sbjct: 1166 PGPRCQKPGAKGCEGRSGDGACDA----GCSGPGGN------WDGGDCSLGVPDPWKGCP 1215

Query: 576  CSNTCTCK-NGGTCLPENGNCVCAPGFRGPSCQR--SCQPGRYGKRCVPCKCANHSFCHP 632
              + C      G C P+  +  C   F G  C+   +C P  Y + C       H  C  
Sbjct: 1216 SHSRCWLLFRDGQCHPQCDSEECL--FDGYDCETPPACTPA-YDQYCHDHFHNGH--CEK 1270

Query: 633  SNGTCYCLAGWTGPDCSQPCPPGHWGENCA 662
               T  C  GW G DC        WG + A
Sbjct: 1271 GCNTAEC--GWDGGDCRPEDGDPEWGPSLA 1298


>gi|148833508 notch1 preproprotein [Homo sapiens]
          Length = 2555

 Score =  236 bits (601), Expect = 1e-61
 Identities = 226/838 (26%), Positives = 293/838 (34%), Gaps = 251/838 (29%)

Query: 99   GFCVPLCAQE--------CVHGRC---VAPNQCQCVPGWRGDDC---SSECAPGMWGPQC 144
            G+  P C  E        CVHG C   +   +C C PGW G +C   ++EC         
Sbjct: 707  GYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESN------ 760

Query: 145  DKPCSCGNNSSC-DPKSG-VCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQT 202
                 C N  +C D  SG VC+C  G   PNC          P     C   G   D   
Sbjct: 761  ----PCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNP-----CLNQGTCIDDVA 811

Query: 203  G-ACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQG----SCSCPPGWMGT 257
            G  C C    TG +C+V  +        PS   C+NGG  +  +     SC CP GW G 
Sbjct: 812  GYKCNCLLPYTGATCEVVLAP-----CAPSP--CRNGGECRQSEDYESFSCVCPTGWQGQ 864

Query: 258  ICSLP-------------------------CPEGFHGPNCS---QECR---CHNGGLCDR 286
             C +                          C  G+ G NC     +CR   CHNGG C  
Sbjct: 865  TCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTD 924

Query: 287  F--TGQCRCAPGYTGDRCREE-------------------------CPVGRFGQDCAETC 319
               T  C C PG+ G  C E+                         CP G  G  C    
Sbjct: 925  GINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNT 984

Query: 320  DCAPDARCFPANGA----------CLCEHGFTGDRCTDRL-------------------- 349
                ++ CF  NG           CLC  GFTG  C   +                    
Sbjct: 985  PDCTESSCF--NGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGS 1042

Query: 350  ----CPDGFYGLSCQ--------APCT----CDREHSLSCHPMNGECSCLPGWAGLHCNE 393
                CP G+ G +CQ        +PC     C + H+         C C  GW GL+C+ 
Sbjct: 1043 YRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHT------QYRCECPSGWTGLYCDV 1096

Query: 394  ---SCPQDTHGPGCQEHCLCLHGGVCQATSGL--CQCAPGYTGPHCASL---CPPDTY-- 443
               SC       G     LC HGG+C        C+C  GYTG +C  L   C P     
Sbjct: 1097 PSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQN 1156

Query: 444  GVNCSA-----RCSCE---NAIACSPIDGECVCKEGWQRGNC-------SVPCPPGTWGF 488
            G  C+       C C    + + CS    EC+       G C          CP GT G 
Sbjct: 1157 GATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGV 1216

Query: 489  SC--------------NASCQCAHEAVCSPQTG--ACTCTPGWHGAHCQLPCPKGQFGEG 532
             C              + S +C +   C  Q G  +CTC PG+ G  C+     G   E 
Sbjct: 1217 HCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCE-----GDVNEC 1271

Query: 533  CASRCDCDHSDGC----DPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTC 588
             ++ CD   +  C    +  H  C+C+AG  G RC          +N      CKNGGTC
Sbjct: 1272 LSNPCDARGTQNCVQRVNDFH--CECRAGHTGRRCESV-------INGCKGKPCKNGGTC 1322

Query: 589  LPENGN-----CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC--HPSNGTCYCLA 641
               +       C C  GF G +C+         + C   +C N   C   P + TC CL 
Sbjct: 1323 AVASNTARGFICKCPAGFEGATCENDA------RTCGSLRCLNGGTCISGPRSPTCLCLG 1376

Query: 642  GWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGS----CICPLGWTG--HHCLEGC 695
             +TGP+C  P      G N      C++ GTC P   S    C+CP  + G   H L+  
Sbjct: 1377 PFTGPECQFPASSPCLGGN-----PCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYS 1431

Query: 696  PLGTFGANCSQP----------CQCGPGEK-CHPETGACVCPPGHSGAPCRIGIQEPF 742
              G  G +   P          CQ   G K C  +     C  G  G  C +   +P+
Sbjct: 1432 FGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHAC--GWDGGDCSLNFNDPW 1487



 Score =  235 bits (599), Expect = 2e-61
 Identities = 202/708 (28%), Positives = 264/708 (37%), Gaps = 183/708 (25%)

Query: 120 CQCVPGWRGDDCSS-------------------------ECAPGMWGPQC-------DKP 147
           C CV GW G+DCS                          EC  G  G  C         P
Sbjct: 321 CVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNP 380

Query: 148 CSCGNNSSCDPKSG--VCSCPSGLQPPNCLQ---PCTPGYYGPACQFRCQCHGAPCDPQT 202
           C+ G+N   +P +G  +C+CPSG   P C Q    C+ G     C+     H   C    
Sbjct: 381 CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLG--ANPCE-----HAGKCINTL 433

Query: 203 GA--CFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGG--VFQTPQGSCSCPPGWMGTI 258
           G+  C C    TGP C++  ++  S       + CQN    + Q  +  C C PG+ G  
Sbjct: 434 GSFECQCLQGYTGPRCEIDVNECVS-------NPCQNDATCLDQIGEFQCICMPGYEGVH 486

Query: 259 CSLPCPEGFHGPNCSQECRCHNGGLCDRFTG-QCRCAPGYTGDRCREECPVGRFGQDCAE 317
           C +   E      C+     HNG   D+    QC C  G+TG  C+ +        +CA 
Sbjct: 487 CEVNTDE------CASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDV------DECAS 534

Query: 318 TCDCAPDARCF--PANGACLCEHGFTGDRC---TDRLCPDGFYGLSCQAPCTCDREHSLS 372
           T  C   A+C   P    C+C  G+TG  C    D   PD         PC     H  S
Sbjct: 535 T-PCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPD---------PC-----HYGS 579

Query: 373 CHP--MNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSG--LCQCAPG 428
           C        C C PG+ G HC  +  + +  P       C HGG CQ      LC C  G
Sbjct: 580 CKDGVATFTCLCRPGYTGHHCETNINECSSQP-------CRHGGTCQDRDNAYLCFCLKG 632

Query: 429 YTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDG-ECVCKEGWQRGNCSVPCPPGTWG 487
            TGP+C          ++  A   C++      IDG EC C+             PG  G
Sbjct: 633 TTGPNC-------EINLDDCASSPCDSGTCLDKIDGYECACE-------------PGYTG 672

Query: 488 FSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDP 547
             CN +     E   +P     TC  G +G  C+  CP+G     C S  +  +S+ C  
Sbjct: 673 SMCNINID---ECAGNPCHNGGTCEDGINGFTCR--CPEGYHDPTCLSEVNECNSNPC-- 725

Query: 548 VHG---------RCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTC--LPENGNCV 596
           VHG         +C C  GW G  C ++  E      C +   C NGGTC  +     C 
Sbjct: 726 VHGACRDSLNGYKCDCDPGWSGTNCDINNNE------CESN-PCVNGGTCKDMTSGYVCT 778

Query: 597 CAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC--HPSNGTCYCLAGWTGPDCS---QP 651
           C  GF GP+CQ +         C    C N   C    +   C CL  +TG  C     P
Sbjct: 779 CREGFSGPNCQTNI------NECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAP 832

Query: 652 CPPGHWGENCAQTCQCHHGGTCHPQDG----SCICPLGWTGHHC---LEGCPLG--TFGA 702
           C P            C +GG C   +     SC+CP GW G  C   +  C L     GA
Sbjct: 833 CAPS----------PCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGA 882

Query: 703 NCSQP-------CQCG-PGEKCHPETGACVCPPGHSGAPCRIGIQEPF 742
           +C          CQ G  G  C  +   C   P H+G  C  GI   F
Sbjct: 883 SCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAF 930



 Score =  230 bits (586), Expect = 6e-60
 Identities = 207/702 (29%), Positives = 272/702 (38%), Gaps = 172/702 (24%)

Query: 99  GFCVPLCA----QECVHGRC----------VAPNQCQCVPGWRGDDCSSECAPGMWGPQC 144
           GF  PLC       C+   C          +   +C+C PGW G  C          P  
Sbjct: 92  GFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQA------DPCA 145

Query: 145 DKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGA 204
             PC+ G        S +C CP     P C Q        P     C+ HG  C  + G+
Sbjct: 146 SNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGL---CR-HGGTCHNEVGS 201

Query: 205 --CFCPAERTGPSCD---VSCSQGTSGFFCPSTHSCQNGGVFQTPQG----SCSCPPGWM 255
             C C A  TGP+C+   V CS        PS   CQNGG  + P G     C+C PG+ 
Sbjct: 202 YRCVCRATHTGPNCERPYVPCS--------PS--PCQNGGTCR-PTGDVTHECACLPGFT 250

Query: 256 GTICSL---PCPEGFHGPNCSQECRCHNGGLC--DRFTGQCRCAPGYTGDRCREECPVGR 310
           G  C      CP    G NC       NGG C     T  CRC P +TG  C E+     
Sbjct: 251 GQNCEENIDDCP----GNNCK------NGGACVDGVNTYNCRCPPEWTGQYCTED----- 295

Query: 311 FGQDCAETCDCAPDA-----RCFPANGA--CLCEHGFTGDRCTDRLCPDGFYGLSCQAPC 363
                 + C   P+A      C   +G   C+C +G+TG+ C++ +  D     +C    
Sbjct: 296 -----VDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENI--DDCASAACFHGA 348

Query: 364 TC-DREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQAT--- 419
           TC DR  S  C   +G    L      H N++C  +           C  G  C      
Sbjct: 349 TCHDRVASFYCECPHGRTGLL-----CHLNDACISNP----------CNEGSNCDTNPVN 393

Query: 420 -SGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDG--ECVCKEGWQRGN 476
              +C C  GYTGP C+      + G N      CE+A  C    G  EC C +G+    
Sbjct: 394 GKAICTCPSGYTGPACSQDVDECSLGAN-----PCEHAGKCINTLGSFECQCLQGYTGPR 448

Query: 477 CSVPCPPGTWGFSCNASCQCAHEAVCSPQTG--ACTCTPGWHGAHCQLPCPKGQFGEGCA 534
           C +          C  S  C ++A C  Q G   C C PG+ G HC++        + CA
Sbjct: 449 CEIDVN------EC-VSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNT------DECA 495

Query: 535 SRCDCDHSDGC-DPVHG-RCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCL--P 590
           S   C H+  C D ++  +C+C  G+ G  C     E      C++T  CKNG  CL  P
Sbjct: 496 S-SPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDE------CAST-PCKNGAKCLDGP 547

Query: 591 ENGNCVCAPGFRGPSCQ---RSCQPG--RYGKRCVPCKCANHSFCHPSNGTCYCLAGWTG 645
               CVC  G+ G  C+     C P    YG     CK    +F      TC C  G+TG
Sbjct: 548 NTYTCVCTEGYTGTHCEVDIDECDPDPCHYGS----CKDGVATF------TCLCRPGYTG 597

Query: 646 PDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGS--CICPLGWTGHHC---LEGCPLGTF 700
             C           N   +  C HGGTC  +D +  C C  G TG +C   L+ C     
Sbjct: 598 HHCET-------NINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDC----- 645

Query: 701 GANCSQPCQCGPGEKCHPETGA--CVCPPGHSGAPCRIGIQE 740
               S PC  G    C  +     C C PG++G+ C I I E
Sbjct: 646 ---ASSPCDSG---TCLDKIDGYECACEPGYTGSMCNINIDE 681



 Score =  217 bits (552), Expect = 5e-56
 Identities = 180/635 (28%), Positives = 245/635 (38%), Gaps = 121/635 (19%)

Query: 141 GPQCDKPC-SCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCD 199
           GP+C +P  +C N   C+  +G  +C            C   + GP CQ    C   PC 
Sbjct: 21  GPRCSQPGETCLNGGKCEAANGTEACV-----------CGGAFVGPRCQDPNPCLSTPCK 69

Query: 200 PQTGACFCPAERTGPSCDVSCSQGTSGFFCPS-------THSCQNGG---VFQTPQGSCS 249
              G C     R       SC+ G SG  C +       T+ C+NGG   +    +  C 
Sbjct: 70  -NAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCR 128

Query: 250 CPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQ--CRCAPGYTGDRCREECP 307
           CPPGW G  C    P       C+    C NGG C  F     C C P + G  CR++  
Sbjct: 129 CPPGWSGKSCQQADP-------CASN-PCANGGQCLPFEASYICHCPPSFHGPTCRQD-- 178

Query: 308 VGRFGQDCAETCDCAPDARCFPANGA--CLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTC 365
           V   GQ       C     C    G+  C+C    TG  C     P         +PC  
Sbjct: 179 VNECGQKPGL---CRHGGTCHNEVGSYRCVCRATHTGPNCERPYVP------CSPSPC-- 227

Query: 366 DREHSLSCHP---MNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGL 422
             ++  +C P   +  EC+CLPG+ G +C E+   D  G  C+    C+ G      +  
Sbjct: 228 --QNGGTCRPTGDVTHECACLPGFTGQNCEENI-DDCPGNNCKNGGACVDG----VNTYN 280

Query: 423 CQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDG--ECVCKEGWQRGNCSVP 480
           C+C P +TG +C           N     +C+N   C    G   CVC  GW   +CS  
Sbjct: 281 CRCPPEWTGQYCTEDVDECQLMPN-----ACQNGGTCHNTHGGYNCVCVNGWTGEDCSEN 335

Query: 481 CPPGTWGFSCNASCQCAHEAVCSPQTGA--CTCTPGWHGAHCQLPCPKGQFGEGCASRCD 538
                    C AS  C H A C  +  +  C C  G  G  C L        + C S   
Sbjct: 336 ID------DC-ASAACFHGATCHDRVASFYCECPHGRTGLLCHL-------NDACISN-P 380

Query: 539 CDHSDGCD--PVHGR--CQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGN 594
           C+    CD  PV+G+  C C +G+ G  C     E   G N      C++ G C+   G+
Sbjct: 381 CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGAN-----PCEHAGKCINTLGS 435

Query: 595 --CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGT--CYCLAGWTGPDCSQ 650
             C C  G+ GP C+           CV   C N + C    G   C C+ G+ G  C  
Sbjct: 436 FECQCLQGYTGPRCEIDVN------ECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEV 489

Query: 651 PCPPGHWGENCAQTCQCHHGGTCHPQ--DGSCICPLGWTGHHC---LEGCPLGTFGANCS 705
                   + CA +  C H G C  +  +  C CP G+TGH C   ++ C         S
Sbjct: 490 NT------DECASS-PCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDEC--------AS 534

Query: 706 QPCQCGPGEKCHPETGACVCPPGHSGAPCRIGIQE 740
            PC+ G      P T  CVC  G++G  C + I E
Sbjct: 535 TPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDE 569


>gi|24041035 notch 2 preproprotein [Homo sapiens]
          Length = 2471

 Score =  215 bits (548), Expect = 2e-55
 Identities = 223/832 (26%), Positives = 283/832 (34%), Gaps = 258/832 (31%)

Query: 120 CQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCD--PKSGVCSCPSGLQ------- 170
           C+C+ G+ G  C ++        +CD P  C +  +C   P S  C CP G         
Sbjct: 168 CKCLTGFTGQKCETDVN------ECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSL 221

Query: 171 -----PPNCLQP--------------CTPGYYGPACQ--------FRCQCHGAPCDP-QT 202
                P  C+                C PG+ G  C+         RCQ  G   D   T
Sbjct: 222 YVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNT 281

Query: 203 GACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGS--CSCPPGWMGTICS 260
             C CP + TG  C     +          ++CQNGG      G   C C  GW G  CS
Sbjct: 282 YNCRCPPQWTGQFCTEDVDECLL-----QPNACQNGGTCANRNGGYGCVCVNGWSGDDCS 336

Query: 261 -------------------------LPCPEGFHGPNCSQECRC-----HNGGLCDR--FT 288
                                      CPEG  G  C  +  C     H G LCD     
Sbjct: 337 ENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLN 396

Query: 289 GQ--CRCAPGYTGDRCRE----------------------------ECPVGRFGQDC--- 315
           GQ  C C  GY G  C E                            EC  G  G  C   
Sbjct: 397 GQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMD 456

Query: 316 ---AETCDCAPDARCFPANGA--CLCEHGFTG------------------DRCTDR---- 348
                +  C  DA C    G   CLC  GF G                   +C D+    
Sbjct: 457 INECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRF 516

Query: 349 --LCPDGFYGLSCQ--------APCTCDREHSLSC--HPMNGECSCLPGWAGLHCNESC- 395
             LCP GF G  CQ         PC     +   C  HP   EC C  G+ G+ C E+  
Sbjct: 517 QCLCPPGFTGPVCQIDIDDCSSTPCL----NGAKCIDHPNGYECQCATGFTGVLCEENID 572

Query: 396 ---PQDTHGPGCQEH-----CLC---LHGGVCQATSGLCQCAPGYTGPHCASL------- 437
              P   H   CQ+      C+C     G +C      C  +P      C  L       
Sbjct: 573 NCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCN 632

Query: 438 CPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCA 497
           C P T GVNC        +  C  I G  +C +G  R +C   C PG  G  CN      
Sbjct: 633 CQPGTSGVNCEINFDDCASNPC--IHG--ICMDGINRYSCV--CSPGFTGQRCNIDID-- 684

Query: 498 HEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHG------- 550
            E   +P     TC  G +G  C   CP+G     C S+ +   S+ C  +HG       
Sbjct: 685 -ECASNPCRKGATCINGVNGFRCI--CPEGPHHPSCYSQVNECLSNPC--IHGNCTGGLS 739

Query: 551 --RCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTC--LPENGNCVCAPGFRGPSC 606
             +C C AGW+G  C +   E L     SN C  +NGGTC  L     C C  GF+G +C
Sbjct: 740 GYKCLCDAGWVGINCEVDKNECL-----SNPC--QNGGTCDNLVNGYRCTCKKGFKGYNC 792

Query: 607 QRSCQPGRYGKRCVPCKCANHSFCHP--SNGTCYCLAGWTGPDCSQP------------- 651
           Q +         C    C N   C    S  TC+C+  +TG +C                
Sbjct: 793 QVNID------ECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAA 846

Query: 652 --------------CPPGHWGENCA---QTC---QCHHGGTCHPQDGS--CICPLGWTGH 689
                         C PG  G+ C      C    C + G CH   GS  C CP G++G 
Sbjct: 847 VCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGM 906

Query: 690 HCLEGCPLGTFGANC-SQPCQCGPGEKCHPETGACVCPPGHSGAPCRIGIQE 740
            C E         +C + PCQ G        T +C+C PG +G  C+  + E
Sbjct: 907 DCEEDID------DCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNE 952



 Score =  211 bits (538), Expect = 2e-54
 Identities = 216/837 (25%), Positives = 291/837 (34%), Gaps = 280/837 (33%)

Query: 120  CQCVPGWRGDDCSSE-------------------------CAPGMWGPQC-------DKP 147
            C CV GW GDDCS                           C  G  G  C         P
Sbjct: 324  CVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNP 383

Query: 148  CSCGNNSSCDPKSG--VCSCPSGLQPPNCLQ----------------------------P 177
            C  G     +P +G  +C+CP G +  +C +                             
Sbjct: 384  CHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCE 443

Query: 178  CTPGYYGPACQFRC-QCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCP------ 230
            C  GY GP C+    +CH  PC        C  +  G +C   C  G  G  C       
Sbjct: 444  CLKGYAGPRCEMDINECHSDPCQ---NDATCLDKIGGFTC--LCMPGFKGVHCELEINEC 498

Query: 231  STHSCQNGG--VFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLC-DRF 287
             ++ C N G  V +  +  C CPPG+ G +C +   +      CS    C NG  C D  
Sbjct: 499  QSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDD------CS-STPCLNGAKCIDHP 551

Query: 288  TG-QCRCAPGYTGDRCREE------------------------CPVGRFGQDCAETCD-- 320
             G +C+CA G+TG  C E                         C  G  G  C++  D  
Sbjct: 552  NGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDEC 611

Query: 321  ----CAPDARCFP-ANG-ACLCEHGFTG------------DRCTDRLCPDGFYGLSCQAP 362
                C  D RC    NG  C C+ G +G            + C   +C DG    SC   
Sbjct: 612  YSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCS 671

Query: 363  -------CTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQ---EHCL--- 409
                   C  D +   S +P     +C+ G  G  C   CP+  H P C      CL   
Sbjct: 672  PGFTGQRCNIDIDECAS-NPCRKGATCINGVNGFRC--ICPEGPHHPSCYSQVNECLSNP 728

Query: 410  CLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSA---RC---SCENAIACSPID 463
            C+HG           C  G +G  C  LC     G+NC      C    C+N   C  + 
Sbjct: 729  CIHG----------NCTGGLSGYKC--LCDAGWVGINCEVDKNECLSNPCQNGGTCDNLV 776

Query: 464  G--ECVCKEGWQRGNCSV--------PC-PPGTW-----GFSCNA-------SCQ----- 495
                C CK+G++  NC V        PC   GT      G++C+        +CQ     
Sbjct: 777  NGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAP 836

Query: 496  -----CAHEAVC--SP--QTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCD 546
                 C + AVC  SP  ++  C C PGW G  C +        + C S+  C +   C 
Sbjct: 837  CSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDI------DECISK-PCMNHGLCH 889

Query: 547  PVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTC------TCKNGGTCLP--ENGNCVCA 598
               G   C+           CP G  G++C           C+NGG+C+      +C+C 
Sbjct: 890  NTQGSYMCE-----------CPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCL 938

Query: 599  PGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC--HPSNGTCYCLAGWTGPDCSQPCPPGH 656
            PGF G  CQ           C+   C N   C  + ++ TC C AG+ G  C        
Sbjct: 939  PGFTGDKCQTDM------NECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNI---- 988

Query: 657  WGENCAQTCQCHHGGTCHPQDG----SCICPLGWTGHHCLE------------------- 693
                C ++  C +GGTC   DG    SC+CP+G+TG  CL                    
Sbjct: 989  --NECTES-SCFNGGTC--VDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDG 1043

Query: 694  ------GCPLGTFGANCS--------QPCQCGPGEKCHPETGACVCPPGHSGAPCRI 736
                   CPLG  G NC          PC+             C+CP G +GA C +
Sbjct: 1044 LGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDV 1100



 Score =  207 bits (526), Expect = 5e-53
 Identities = 206/762 (27%), Positives = 269/762 (35%), Gaps = 222/762 (29%)

Query: 109  CVHGRC---VAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDP--KSGVC 163
            C+HG C   ++  +C C  GW G +C  +    +  P       C N  +CD       C
Sbjct: 729  CIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNP-------CQNGGTCDNLVNGYRC 781

Query: 164  SCPSGLQPPNCL--------QPCT---------PGYYG----PACQFRCQCHGAPCDPQT 202
            +C  G +  NC          PC           GY      P     CQ   APC P  
Sbjct: 782  TCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNP 841

Query: 203  --GACFCPAERTGPSCDVSCSQGTSGFFCPS------THSCQNGGVFQTPQGS--CSCPP 252
               A  C       S    C+ G  G  C        +  C N G+    QGS  C CPP
Sbjct: 842  CENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPP 901

Query: 253  GWMGTICSLPCPEGFHGPNCSQECRCHNGGLC--DRFTGQCRCAPGYTGDRCREE----- 305
            G+ G  C     +    P       C NGG C     T  C C PG+TGD+C+ +     
Sbjct: 902  GFSGMDCEEDIDDCLANP-------CQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECL 954

Query: 306  --------------------CPVGRFGQDCAETCDCAPDARCFPANG----------ACL 335
                                C  G  G  C    +   ++ CF  NG          +CL
Sbjct: 955  SEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCF--NGGTCVDGINSFSCL 1012

Query: 336  CEHGFTGDRCTDRL------------------------CPDGFYGLSCQ--------APC 363
            C  GFTG  C   +                        CP G+ G +CQ        +PC
Sbjct: 1013 CPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPC 1072

Query: 364  ----TCDREHSLSCHPMNGECSCLPGWAGLHC---NESCPQDTHGPGCQEHCLCLHGGVC 416
                TC ++ + S      +C C  GWAG +C   N SC       G     LC H GVC
Sbjct: 1073 KNKGTCVQKKAES------QCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVC 1126

Query: 417  --QATSGLCQCAPGYTGPHCASLCP-----PDTYGVNCSA-----RCSCE---NAIACSP 461
                 +  CQC  GYTG +C          P  +G  CS      RC C      + C  
Sbjct: 1127 INAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEY 1186

Query: 462  IDGECVCKEGWQRGNC-------SVPCPPGTWGFSCNASCQ-------CAHEAVCSPQTG 507
               EC  +     G C          CPPGT G  C  +         C +   C  + G
Sbjct: 1187 EVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIG 1246

Query: 508  --ACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGR--CQCQAGWMGARC 563
              +C C PG+ G  C+     G   E  ++ C  + S  C  +     C C++ + G  C
Sbjct: 1247 GYSCRCLPGFAGERCE-----GDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHC 1301

Query: 564  HLS---CPEGLWGVNCSNTCTCKNGGTC-----LPENGNCVCAPGFRGPSCQRSC--QPG 613
                  CP+            C NGGTC     +P+   C C PGF G  CQ SC     
Sbjct: 1302 ETFVDVCPQ----------MPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKC 1351

Query: 614  RYGKRCVPCKCANHSFCHPSNG-TCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGT 672
            R G++CV          H ++G  C+C    +  DC   C           +  C HGG+
Sbjct: 1352 RKGEQCV----------HTASGPRCFCP---SPRDCESGC----------ASSPCQHGGS 1388

Query: 673  CHPQDG----SCICPLGWTGHHC-LEGCPLGTFGANC-SQPC 708
            CHPQ      SC C   ++G  C L   P  T  A C SQ C
Sbjct: 1389 CHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYC 1430



 Score =  201 bits (512), Expect = 2e-51
 Identities = 212/839 (25%), Positives = 277/839 (33%), Gaps = 266/839 (31%)

Query: 101  CVPLCAQECVH-GRCVAPN---QCQCVPGWRGDDCSSE---------------------- 134
            C    +  C H G+CV  +    C+C+ G+ G  C  +                      
Sbjct: 419  CAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGF 478

Query: 135  ---CAPGMWGPQCDKPCS------CGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGP 185
               C PG  G  C+   +      C NN  C  K     C            C PG+ GP
Sbjct: 479  TCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCL-----------CPPGFTGP 527

Query: 186  ACQFRCQ-CHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFC----------PSTHS 234
             CQ     C   PC        C     G  C   C+ G +G  C          P  H 
Sbjct: 528  VCQIDIDDCSSTPC---LNGAKCIDHPNGYECQ--CATGFTGVLCEENIDNCDPDPCHHG 582

Query: 235  -CQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQ----------ECRCHNG-- 281
             CQ+G        +C C PG+MG ICS    E +  P  +           +C C  G  
Sbjct: 583  QCQDG----IDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTS 638

Query: 282  ------------------GLC----DRFTGQCRCAPGYTGDRCR---EECPVG--RFGQD 314
                              G+C    +R++  C C+PG+TG RC    +EC     R G  
Sbjct: 639  GVNCEINFDDCASNPCIHGICMDGINRYS--CVCSPGFTGQRCNIDIDECASNPCRKGAT 696

Query: 315  CAE-----TCDCAPDAR---CFPANGACL--------CEHGFTGDRCTDRLCPDGFYGLS 358
            C        C C        C+     CL        C  G +G +C   LC  G+ G++
Sbjct: 697  CINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKC---LCDAGWVGIN 753

Query: 359  CQAPCTCDREHSLSCHPMNG----------ECSCLPGWAGLHCNESCPQDTHGPGCQEHC 408
            C+     D+   LS    NG           C+C  G+ G +C  +  +    P      
Sbjct: 754  CEV----DKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNP------ 803

Query: 409  LCLHGGVC--QATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDG-- 464
             CL+ G C    +   C C   YTG +C ++  P      CS    CENA  C       
Sbjct: 804  -CLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAP------CSPN-PCENAAVCKESPNFE 855

Query: 465  --ECVCKEGWQRGNCSVP-------------------------CPPGTWGFSCNAS---- 493
               C+C  GWQ   C++                          CPPG  G  C       
Sbjct: 856  SYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDC 915

Query: 494  ----CQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGC-DPV 548
                CQ     +    T +C C PG+ G  CQ    +      C S   C +   C D V
Sbjct: 916  LANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNE------CLSE-PCKNGGTCSDYV 968

Query: 549  HG-RCQCQAGWMGARCHLSCPEGLWGVNCSNTCT---CKNGGTCLP--ENGNCVCAPGFR 602
            +   C+CQAG+ G  C           N  N CT   C NGGTC+    + +C+C  GF 
Sbjct: 969  NSYTCKCQAGFDGVHCE----------NNINECTESSCFNGGTCVDGINSFSCLCPVGFT 1018

Query: 603  GPSCQR-------------------------SCQPGRYGKRCV---------PCKCANHS 628
            G  C                           SC  G  GK C          PCK     
Sbjct: 1019 GSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTC 1078

Query: 629  FCHPSNGTCYCLAGWTGPDCSQP---CPPGHWGENCAQTCQCHHGGTCHPQDGS--CICP 683
                +   C C +GW G  C  P   C              C H G C     +  C CP
Sbjct: 1079 VQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCP 1138

Query: 684  LGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGA--CVCPPGHSGAPCRIGIQE 740
            LG+TG +C E           S PCQ   G  C    G   C C PG+ G  C   + E
Sbjct: 1139 LGYTGSYCEE-----QLDECASNPCQ--HGATCSDFIGGYRCECVPGYQGVNCEYEVDE 1190



 Score =  192 bits (489), Expect = 1e-48
 Identities = 214/842 (25%), Positives = 283/842 (33%), Gaps = 254/842 (30%)

Query: 109 CVHGRCVAPNQCQCVPGWRGDDC----------------------------SSECAPGMW 140
           CV    +    C+C  G+ G+DC                               C  G  
Sbjct: 79  CVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFT 138

Query: 141 GPQC-------DKPCSCGNNSSCDPKSGVCSCPSGLQPPNC---LQPC-TPGY--YGPAC 187
           G +C         PC+ G+  +       C C +G     C   +  C  PG+  +G  C
Sbjct: 139 GKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTC 198

Query: 188 -----QFRCQC----HGAPCDPQTGACFCPAERTGPSC--------DVSCSQGTSGFFCP 230
                 ++CQC     G  CD     C       G +C        + +C  G  G  C 
Sbjct: 199 LNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCE 258

Query: 231 ------STHSCQNGGVFQTPQG--SCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGG 282
                   H CQNGGV        +C CPP W G  C+    E    PN      C NGG
Sbjct: 259 RNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNA-----CQNGG 313

Query: 283 LCDRFTG--QCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFP--ANGACLCEH 338
            C    G   C C  G++GD C E         DCA    C P + C    A+ +C+C  
Sbjct: 314 TCANRNGGYGCVCVNGWSGDDCSENI------DDCA-FASCTPGSTCIDRVASFSCMCPE 366

Query: 339 GFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGE--CSCLPGWAGLHCNE--- 393
           G  G  C      D      C     CD       +P+NG+  C+C  G+ G  C E   
Sbjct: 367 GKAGLLCH---LDDACISNPCHKGALCD------TNPLNGQYICTCPQGYKGADCTEDVD 417

Query: 394 SCPQDTHGPGCQEHCLCLHGGVCQATSGL--CQCAPGYTGPHC----------------- 434
            C      P       C H G C  T G   C+C  GY GP C                 
Sbjct: 418 ECAMANSNP-------CEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDAT 470

Query: 435 --------ASLCPPDTYGVNCSARCS-CENAIACSPIDGECVCKEGWQRGNCSVPCPPGT 485
                     LC P   GV+C    + C++    +  +G+CV K    R  C   CPPG 
Sbjct: 471 CLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVN--NGQCVDKV--NRFQCL--CPPGF 524

Query: 486 WGFSCN------ASCQCAHEAVC--SPQTGACTCTPGWHGAHCQL--------PCPKGQF 529
            G  C       +S  C + A C   P    C C  G+ G  C+         PC  GQ 
Sbjct: 525 TGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQC 584

Query: 530 GEG----------------CASRCDCDHSDGC-------DPVHG-RCQCQAGWMGARCHL 565
            +G                C+ + D  +S  C       D V+G +C CQ G  G  C +
Sbjct: 585 QDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEI 644

Query: 566 SCPEGLWGVNCSNTCTCKNGGTCLP--ENGNCVCAPGFRGPSCQ--------------RS 609
           +  +       SN C     G C+      +CVC+PGF G  C                +
Sbjct: 645 NFDD-----CASNPCI---HGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGAT 696

Query: 610 CQPGRYGKRCVPCKCANHSFCHPSNGTCY--------CLAGWTGPDCSQPCPPGHWGENC 661
           C  G  G RC+  +  +H  C+     C         C  G +G  C   C  G  G NC
Sbjct: 697 CINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCL--CDAGWVGINC 754

Query: 662 ------AQTCQCHHGGTCH--PQDGSCICPLGWTGHHC---------------------L 692
                   +  C +GGTC        C C  G+ G++C                     +
Sbjct: 755 EVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDI 814

Query: 693 EG----CPLGTFGANCS---QPCQCGPGEKC-------HPETGACVCPPGHSGAPCRIGI 738
            G    C L   G NC     PC   P E         + E+  C+C PG  G  C I I
Sbjct: 815 SGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDI 874

Query: 739 QE 740
            E
Sbjct: 875 DE 876



 Score =  187 bits (475), Expect = 4e-47
 Identities = 195/759 (25%), Positives = 253/759 (33%), Gaps = 209/759 (27%)

Query: 135 CAPGMWGPQC-DKPCSCGNNSSC---DPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFR 190
           CA      QC D    C N   C      +G C CP G     C       +  P  + R
Sbjct: 19  CAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQ------HRDPCEKNR 72

Query: 191 CQCHGAPCDPQT----GACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGG---VFQT 243
           CQ +G  C  Q       C C +  TG  C  S S       C  +  C NGG   +   
Sbjct: 73  CQ-NGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP-----CFVSRPCLNGGTCHMLSR 126

Query: 244 PQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQ--CRCAPGYTGDR 301
               C+C  G+ G  C           +      C NG  C     Q  C+C  G+TG +
Sbjct: 127 DTYECTCQVGFTGKECQWT--------DACLSHPCANGSTCTTVANQFSCKCLTGFTGQK 178

Query: 302 CREECPVGRFGQDCAETCDCAPDARCF--PANGACLCEHGFTGDRCTDRLCPDGFYGLSC 359
           C  +        +C     C     C   P +  C C  GFTG  C      D  Y    
Sbjct: 179 CETDV------NECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYC------DSLYVPCA 226

Query: 360 QAPC----TCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGV 415
            +PC    TC +    +      EC+CLPG+ G  C  +         C  H  C +GGV
Sbjct: 227 PSPCVNGGTCRQTGDFTF-----ECNCLPGFEGSTCERNIDD------CPNH-RCQNGGV 274

Query: 416 CQ--ATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGE--CVCKEG 471
           C     +  C+C P +TG  C           N     +C+N   C+  +G   CVC  G
Sbjct: 275 CVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPN-----ACQNGGTCANRNGGYGCVCVNG 329

Query: 472 WQRGNCS--------VPCPPGTWGFS--CNASCQCAH--EAVCSPQTGACTCTPGWHGAH 519
           W   +CS          C PG+       + SC C      +      AC   P   GA 
Sbjct: 330 WSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGAL 389

Query: 520 CQL---------PCPKGQFGEGCASRCD---------CDHSDGCDPVHG--RCQCQAGWM 559
           C            CP+G  G  C    D         C+H+  C    G   C+C  G+ 
Sbjct: 390 CDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYA 449

Query: 560 GARCHLS-------------------------CPEGLWGVNCS---NTCT---CKNGGTC 588
           G RC +                          C  G  GV+C    N C    C N G C
Sbjct: 450 GPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQC 509

Query: 589 LPENGN--CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC--HPSNGTCYCLAGWT 644
           + +     C+C PGF GP CQ           C    C N + C  HP+   C C  G+T
Sbjct: 510 VDKVNRFQCLCPPGFTGPVCQIDIDD------CSSTPCLNGAKCIDHPNGYECQCATGFT 563

Query: 645 GPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDG----SCICPLGWTGHHCLE------- 693
           G  C +        +NC     CHHG     QDG    +CIC  G+ G  C +       
Sbjct: 564 GVLCEENI------DNCDPD-PCHHGQC---QDGIDSYTCICNPGYMGAICSDQIDECYS 613

Query: 694 ------------------GCPLGTFGANC--------SQPC--------------QCGPG 713
                              C  GT G NC        S PC               C PG
Sbjct: 614 SPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPG 673

Query: 714 ---EKCHPETGACVCPPGHSGAPCRIGIQEPFTVMPTTP 749
              ++C+ +   C   P   GA C  G+     + P  P
Sbjct: 674 FTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGP 712



 Score =  138 bits (347), Expect = 3e-32
 Identities = 147/528 (27%), Positives = 195/528 (36%), Gaps = 107/528 (20%)

Query: 102  VPLCAQE-CVH-GRCV---APNQCQCVPGWRGDDC-----SSECAPGMWGPQCDKPCSCG 151
            V LC++  C + G CV   A +QC C  GW G  C     S + A    G   +  C   
Sbjct: 1064 VNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHS 1123

Query: 152  NNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGA--CFCPA 209
                    +  C CP G     C +        P     CQ HGA C    G   C C  
Sbjct: 1124 GVCINAGNTHYCQCPLGYTGSYCEEQLDECASNP-----CQ-HGATCSDFIGGYRCECVP 1177

Query: 210  ERTGPSCDVSCSQGTSGFFCPSTHSCQNGG--VFQTPQGSCSCPPGWMGTICSLPCPEGF 267
               G +C+    +      C +   CQNGG  +       CSCPPG  G +C     +  
Sbjct: 1178 GYQGVNCEYEVDE------CQN-QPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCA 1230

Query: 268  HGPNCSQECRCHNGGLC-DRFTG-QCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDA 325
             GP+C       NGG C DR  G  CRC PG+ G+RC      G   +  +  C      
Sbjct: 1231 RGPHCL------NGGQCMDRIGGYSCRCLPGFAGERCE-----GDINECLSNPCSSEGSL 1279

Query: 326  RCFPANG--ACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNG-ECSC 382
             C        C+C   FTG  C      + F  +  Q PC      +++ +  +G  C C
Sbjct: 1280 DCIQLTNDYLCVCRSAFTGRHC------ETFVDVCPQMPCLNGGTCAVASNMPDGFICRC 1333

Query: 383  LPGWAGLHCNESCPQ-----------DTHGP--------GCQEHCL---CLHGGVC---- 416
             PG++G  C  SC Q              GP         C+  C    C HGG C    
Sbjct: 1334 PPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQR 1393

Query: 417  QATSGLCQCAPGYTGPHC-ASLCPPDTYGVNC-SARCS-------CE---NAIACSPIDG 464
            Q     CQCAP ++G  C     PP T    C S  C+       C+   N+ AC    G
Sbjct: 1394 QPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGG 1453

Query: 465  ECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPC 524
            +C         NCS P P   W +  N   QC  + +C+  T  C     +    CQ   
Sbjct: 1454 DCSLTMENPWANCSSPLP--CWDYINN---QC--DELCN--TVECL----FDNFECQGNS 1500

Query: 525  PKGQFGEGCASRCDCDHSD-GCDPVHGRCQCQAGWMGARCHLSCPEGL 571
               ++ + CA     +H D GC+        + GW G  C    PE L
Sbjct: 1501 KTCKYDKYCADHFKDNHCDQGCNSE------ECGWDGLDCAADQPENL 1542


>gi|153946395 tenascin C precursor [Homo sapiens]
          Length = 2201

 Score =  214 bits (544), Expect = 4e-55
 Identities = 182/622 (29%), Positives = 234/622 (37%), Gaps = 190/622 (30%)

Query: 191 CQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHS------CQNGGVFQTP 244
           C C  AP   +  +     E    S    C+ G      P+T        C   G F T 
Sbjct: 111 CGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTE 170

Query: 245 QGSCSCPPGWMGTICSLP------------------CPEGFHGPNCSQ---ECRCHNGGL 283
              C C PGW G  CS P                  C +GF G +CSQ      C++ G 
Sbjct: 171 GCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGK 230

Query: 284 CDRFTGQCRCAPGYTGDRC-REECPV------------------GRFGQDCAETC---DC 321
           C    G C C  GY G  C RE CPV                  G  G DC +     +C
Sbjct: 231 C--VNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNC 288

Query: 322 APDARCFPANGACLCEHGFTGDRCTDRLCP-----------------DGFYGLSCQAPCT 364
               RC      C+C+ GFTG+ C++ +CP                 +GF G  C  P T
Sbjct: 289 YNRGRC--VENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKP-T 345

Query: 365 CDREHSLSCHPM----NGECSCLPGWAGLHCNES-CPQDTHGPGCQEHCLCLHGGVCQAT 419
           C      +CH       G+C C  G+AG+ C+E  CP D H  G             +  
Sbjct: 346 CPH----ACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRG-------------RCV 388

Query: 420 SGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCS- 478
            G C+C  G+TG  C  L  P+     CS    C        ++G+CVC EG+   +CS 
Sbjct: 389 DGRCECDDGFTGADCGELKCPN----GCSGHGRC--------VNGQCVCDEGYTGEDCSQ 436

Query: 479 VPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHC-QLPCPKGQFGEGCASRC 537
           + CP       C++  +C          G C C  G+ G  C  + CP            
Sbjct: 437 LRCPN-----DCHSRGRCVE--------GKCVCEQGFKGYDCSDMSCPN----------- 472

Query: 538 DCDHSDGCDPVHGRCQCQAGWMGARCH-LSCPEGLWGVNCSNTCTCKNGGTCLPENGNCV 596
           DC     C  V+G C C  G+ G  C    CP             C N G C+  +G CV
Sbjct: 473 DCHQHGRC--VNGMCVCDDGYTGEDCRDRQCPR-----------DCSNRGLCV--DGQCV 517

Query: 597 CAPGFRGPSC-QRSCQPGRYGK-RCVPCKCANHSFCHPSNGTCYCLAGWTGPDC-SQPCP 653
           C  GF GP C + SC    +G+ RCV             NG C C  G+ G DC  Q CP
Sbjct: 518 CEDGFTGPDCAELSCPNDCHGQGRCV-------------NGQCVCHEGFMGKDCKEQRCP 564

Query: 654 PGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHC-LEGCPLGTFGANCSQPCQCGP 712
                        CH  G C   DG CIC  G+TG  C    CP     ++C+   QC  
Sbjct: 565 -----------SDCHGQGRC--VDGQCICHEGFTGLDCGQHSCP-----SDCNNLGQC-- 604

Query: 713 GEKCHPETGACVCPPGHSGAPC 734
                  +G C+C  G+SG  C
Sbjct: 605 ------VSGRCICNEGYSGEDC 620



 Score =  199 bits (505), Expect = 1e-50
 Identities = 167/559 (29%), Positives = 221/559 (39%), Gaps = 147/559 (26%)

Query: 150 CGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPA 209
           C    +   +   C C  G + PNC +P  PG     C  R +C         G C C  
Sbjct: 161 CSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGN----CHLRGRCID-------GQCICDD 209

Query: 210 ERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGT-----ICSLPCP 264
             TG  C        S   CPS   C + G  +   G C C  G+ G      IC +PC 
Sbjct: 210 GFTGEDC--------SQLACPS--DCNDQG--KCVNGVCICFEGYAGADCSREICPVPCS 257

Query: 265 EGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREE---CPVGRFGQDCAETC-- 319
           E  HG      C CH+G   D           Y   RC E    C  G  G+DC+E    
Sbjct: 258 EE-HGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICP 316

Query: 320 -DCAPDARCFPANGACLCEHGFTGDRCTDRLCP-----------------DGFYGLSC-Q 360
            DC    RC   NG C CE GFTG+ C    CP                 +GF G+ C +
Sbjct: 317 NDCFDRGRCI--NGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSE 374

Query: 361 APCTCDREHSLSCHPMNGECSCLPGWAGLHCNE-SCPQDTHGPGCQEHCLCLHGGVCQAT 419
             C  D  +   C  ++G C C  G+ G  C E  CP      GC  H  C++G      
Sbjct: 375 KRCPADCHNRGRC--VDGRCECDDGFTGADCGELKCPN-----GCSGHGRCVNGQ----- 422

Query: 420 SGLCQCAPGYTGPHCASL-CPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCS 478
              C C  GYTG  C+ L CP D     C +R  C        ++G+CVC++G++  +CS
Sbjct: 423 ---CVCDEGYTGEDCSQLRCPND-----CHSRGRC--------VEGKCVCEQGFKGYDCS 466

Query: 479 -VPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQ-LPCPKGQFGEGCASR 536
            + CP       C+   +C +        G C C  G+ G  C+   CP+          
Sbjct: 467 DMSCPN-----DCHQHGRCVN--------GMCVCDDGYTGEDCRDRQCPR---------- 503

Query: 537 CDCDHSDGCDPVHGRCQCQAGWMGARC-HLSCPEGLWGVNCSNTCTCKNGGTCLPENGNC 595
            DC +   C  V G+C C+ G+ G  C  LSCP             C   G C+  NG C
Sbjct: 504 -DCSNRGLC--VDGQCVCEDGFTGPDCAELSCPND-----------CHGQGRCV--NGQC 547

Query: 596 VCAPGFRGPSC-QRSCQPGRYGK-RCVPCKCANH--------------SFCHPS----NG 635
           VC  GF G  C ++ C    +G+ RCV  +C  H              S C+      +G
Sbjct: 548 VCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSG 607

Query: 636 TCYCLAGWTGPDCSQPCPP 654
            C C  G++G DCS+  PP
Sbjct: 608 RCICNEGYSGEDCSEVSPP 626



 Score =  187 bits (475), Expect = 4e-47
 Identities = 153/553 (27%), Positives = 214/553 (38%), Gaps = 160/553 (28%)

Query: 120 CQCVPGWRGDDCSSE------------------CAPGMWGPQCDK---PCSCGNNSSCDP 158
           C C PGW+G +CS                    C  G  G  C +   P  C +   C  
Sbjct: 174 CVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKC-- 231

Query: 159 KSGVCSCPSGLQPPNCLQ-----PCTPGYYGPACQFRCQCH----GAPCDPQTGACFCPA 209
            +GVC C  G    +C +     PC+   +G      C CH    G  C+       C  
Sbjct: 232 VNGVCICFEGYAGADCSREICPVPCSE-EHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYN 290

Query: 210 ERTGPSCDVSCSQGTSGFFCPS---THSCQNGGVFQTPQGSCSCPPGWMGTICSLP---- 262
                  +  C +G +G  C      + C + G  +   G+C C  G+ G  C  P    
Sbjct: 291 RGRCVENECVCDEGFTGEDCSELICPNDCFDRG--RCINGTCYCEEGFTGEDCGKPTCPH 348

Query: 263 --------------CPEGFHGPNCSQE---CRCHNGGLCDRFTGQCRCAPGYTGDRCRE- 304
                         C EGF G +CS++     CHN G C    G+C C  G+TG  C E 
Sbjct: 349 ACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRC--VDGRCECDDGFTGADCGEL 406

Query: 305 ECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCT 364
           +CP G           C+   RC   NG C+C+ G+TG+ C+   CP+      C +   
Sbjct: 407 KCPNG-----------CSGHGRC--VNGQCVCDEGYTGEDCSQLRCPN-----DCHSRGR 448

Query: 365 CDREHSLSCHPMNGECSCLPGWAGLHCNE-SCPQDTHGPGCQEHCLCLHGGVCQATSGLC 423
           C          + G+C C  G+ G  C++ SCP D     C +H  C+        +G+C
Sbjct: 449 C----------VEGKCVCEQGFKGYDCSDMSCPND-----CHQHGRCV--------NGMC 485

Query: 424 QCAPGYTGPHCAS-LCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCS-VPC 481
            C  GYTG  C    CP D     CS R  C        +DG+CVC++G+   +C+ + C
Sbjct: 486 VCDDGYTGEDCRDRQCPRD-----CSNRGLC--------VDGQCVCEDGFTGPDCAELSC 532

Query: 482 PPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHC-QLPCPKGQFGEGCASRCDCD 540
           P       C+   +C +        G C C  G+ G  C +  CP    G+G   RC   
Sbjct: 533 PN-----DCHGQGRCVN--------GQCVCHEGFMGKDCKEQRCPSDCHGQG---RC--- 573

Query: 541 HSDGCDPVHGRCQCQAGWMGARC-HLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAP 599
                  V G+C C  G+ G  C   SCP             C N G C+  +G C+C  
Sbjct: 574 -------VDGQCICHEGFTGLDCGQHSCPS-----------DCNNLGQCV--SGRCICNE 613

Query: 600 GFRGPSCQRSCQP 612
           G+ G  C     P
Sbjct: 614 GYSGEDCSEVSPP 626



 Score =  167 bits (423), Expect = 5e-41
 Identities = 137/461 (29%), Positives = 177/461 (38%), Gaps = 131/461 (28%)

Query: 91  CHGFYESRGFCVPLCAQECVH-GRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCS 149
           CH  +       PLC   C + GRCV  N+C C  G+ G+DCS    P            
Sbjct: 270 CHDGFAGDDCNKPLCLNNCYNRGRCVE-NECVCDEGFTGEDCSELICPN----------D 318

Query: 150 CGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPA 209
           C +   C   +G C C  G    +C +P  P     AC  + +C       + G C C  
Sbjct: 319 CFDRGRCI--NGTCYCEEGFTGEDCGKPTCPH----ACHTQGRC-------EEGQCVCDE 365

Query: 210 ERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICS-LPCPEGFH 268
              G    V CS+      CP+   C N G  +   G C C  G+ G  C  L CP G  
Sbjct: 366 GFAG----VDCSEKR----CPA--DCHNRG--RCVDGRCECDDGFTGADCGELKCPNG-- 411

Query: 269 GPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCRE------------------ECPVGR 310
              CS   RC NG        QC C  GYTG+ C +                   C  G 
Sbjct: 412 ---CSGHGRCVNG--------QCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGF 460

Query: 311 FGQDCAE-TC--DCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDR 367
            G DC++ +C  DC    RC   NG C+C+ G+TG+ C DR CP       C     C  
Sbjct: 461 KGYDCSDMSCPNDCHQHGRC--VNGMCVCDDGYTGEDCRDRQCP-----RDCSNRGLC-- 511

Query: 368 EHSLSCHPMNGECSCLPGWAGLHCNE-SCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCA 426
                   ++G+C C  G+ G  C E SCP D HG G             +  +G C C 
Sbjct: 512 --------VDGQCVCEDGFTGPDCAELSCPNDCHGQG-------------RCVNGQCVCH 550

Query: 427 PGYTGPHC-ASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSV-PCPPG 484
            G+ G  C    CP D +G     RC          +DG+C+C EG+   +C    CP  
Sbjct: 551 EGFMGKDCKEQRCPSDCHG---QGRC----------VDGQCICHEGFTGLDCGQHSCPS- 596

Query: 485 TWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCP 525
                CN   QC         +G C C  G+ G  C    P
Sbjct: 597 ----DCNNLGQCV--------SGRCICNEGYSGEDCSEVSP 625



 Score =  165 bits (417), Expect = 2e-40
 Identities = 137/453 (30%), Positives = 174/453 (38%), Gaps = 137/453 (30%)

Query: 291 CRCAPGYTGDRCRE-ECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRL 349
           C C PG+ G  C E ECP            +C    RC   +G C+C+ GFTG+ C+   
Sbjct: 174 CVCEPGWKGPNCSEPECPG-----------NCHLRGRCI--DGQCICDDGFTGEDCSQLA 220

Query: 350 CPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCN-ESCPQDTHGPGCQEHC 408
           CP       C     C          +NG C C  G+AG  C+ E CP     P  +EH 
Sbjct: 221 CPS-----DCNDQGKC----------VNGVCICFEGYAGADCSREICPV----PCSEEHG 261

Query: 409 LCLHGGVCQATSGLCQCAPGYTGPHCAS-LCPPDTYGVNCSARCSCENAIACSPIDGECV 467
            C+         GLC C  G+ G  C   LC       NC  R  C        ++ ECV
Sbjct: 262 TCV--------DGLCVCHDGFAGDDCNKPLCLN-----NCYNRGRC--------VENECV 300

Query: 468 CKEGWQRGNCS-VPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLP-CP 525
           C EG+   +CS + CP             C     C    G C C  G+ G  C  P CP
Sbjct: 301 CDEGFTGEDCSELICPN-----------DCFDRGRCI--NGTCYCEEGFTGEDCGKPTCP 347

Query: 526 KGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARC-HLSCPEGLWGVNCSNTCTCKN 584
                +G   RC+           G+C C  G+ G  C    CP             C N
Sbjct: 348 HACHTQG---RCE----------EGQCVCDEGFAGVDCSEKRCP-----------ADCHN 383

Query: 585 GGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWT 644
            G C+  +G C C  GF G  C         G+   P  C+ H  C   NG C C  G+T
Sbjct: 384 RGRCV--DGRCECDDGFTGADC---------GELKCPNGCSGHGRC--VNGQCVCDEGYT 430

Query: 645 GPDCSQ-PCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLE-GCPLGTFGA 702
           G DCSQ  CP             CH  G C   +G C+C  G+ G+ C +  CP      
Sbjct: 431 GEDCSQLRCPN-----------DCHSRGRC--VEGKCVCEQGFKGYDCSDMSCP-----N 472

Query: 703 NCSQPCQCGPGEKCHPETGACVCPPGHSGAPCR 735
           +C Q  +C          G CVC  G++G  CR
Sbjct: 473 DCHQHGRC--------VNGMCVCDDGYTGEDCR 497


>gi|4557679 jagged 1 precursor [Homo sapiens]
          Length = 1218

 Score =  213 bits (543), Expect = 6e-55
 Identities = 198/707 (28%), Positives = 263/707 (37%), Gaps = 158/707 (22%)

Query: 104 LCAQECV--HGRCVAPNQCQCVPGWRGDDCSSECAP--GMWGPQCDKPCSCGNNSSCDPK 159
           +C Q C   HG C  P  C+C  GW+G  C  +C P  G     C++P  C     C+  
Sbjct: 233 ICRQGCSPKHGSCKLPGDCRCQYGWQGLYCD-KCIPHPGCVHGICNEPWQC----LCETN 287

Query: 160 SGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVS 219
            G   C   L      QPC  G         C   G    P    C CP   +GP+C+++
Sbjct: 288 WGGQLCDKDLNYCGTHQPCLNGG-------TCSNTG----PDKYQCSCPEGYSGPNCEIA 336

Query: 220 CSQGTSGFFCPSTHSCQNGGVFQTPQG-SCSCPPGWMGTICSLPCPEGFHGPNCSQECRC 278
                    C S      G   +T  G  C C PGW G  CS    +      CS    C
Sbjct: 337 ------EHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDD------CSPN-NC 383

Query: 279 HNGGLCDRFTG--QCRCAPGYTGDRCREECPVGRFGQDC-AETCDCAPDARCFPANGACL 335
            +GG C       +C C P +TG  C+ +        +C A+ C  A   +   A+  C 
Sbjct: 384 SHGGTCQDLVNGFKCVCPPQWTGKTCQLDA------NECEAKPCVNAKSCKNLIASYYCD 437

Query: 336 CEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPM-NG-ECSCLPGWAGLHCN- 392
           C  G+ G  C   +         C   C    ++  SC  + NG  C C PG+AG HC  
Sbjct: 438 CLPGWMGQNCDININ-------DCLGQC----QNDASCRDLVNGYRCICPPGYAGDHCER 486

Query: 393 --ESCPQDT--HGPGCQEH-----CLC---LHGGVCQATSGLCQCAPGYTGPHCASL--- 437
             + C  +   +G  CQ       CLC     G +CQ     C+  P   G  C +    
Sbjct: 487 DIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASD 546

Query: 438 ----CPPDTYGVNCSA---RC---------SCENAIA---------------CSPIDGEC 466
               CP D  G NCS     C         SC  A+A               C P  G+C
Sbjct: 547 YFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGP-HGKC 605

Query: 467 VCKEGWQRGNCSVPCPPGTWGFSCNAS---CQ---CAHEAVCSPQTGA--CTCTPGWHGA 518
             + G   G  +  C  G  G  C+ +   C+   C +   C     +  C C+ GW GA
Sbjct: 606 KSQSG---GKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGA 662

Query: 519 HCQLPCPKGQFGEGCASRCDCDHSDGC-DPVHG-RCQCQAGWMGARCHLSCPEGLWGVNC 576
           +C+             S+  C +   C D V+   C C+ GW G  CH    +       
Sbjct: 663 YCETNIND-------CSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ------- 708

Query: 577 SNTCTCKNGGTCLPENG--NCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC--HP 632
            +  TC NGGTC  E     C+C  G+ G +C  +         C+P  C N   C  + 
Sbjct: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIA-----RNSSCLPNPCHNGGTCVVNG 763

Query: 633 SNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDG--SCICPLGWTGHH 690
            + TC C  GW GP C+Q         N      C++ GTC   D    C C  G+ G  
Sbjct: 764 ESFTCVCKEGWEGPICAQ-------NTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPD 816

Query: 691 CLEGCPLGTFGANCSQPCQCGPGEKCHPETGA--CVCPPGHSGAPCR 735
           C           N  Q   C  G  C  E     CVCPPGHSGA C+
Sbjct: 817 C-------RININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ 856



 Score =  200 bits (509), Expect = 5e-51
 Identities = 202/786 (25%), Positives = 272/786 (34%), Gaps = 194/786 (24%)

Query: 52  SEPCERPWEGPHTCPQPTVVYRTVYRQVVKTDHRQRLQC-----CHGFYESRGFCVPLCA 106
           ++ C   W GP          R + RQ     H     C     C   Y  +G     C 
Sbjct: 217 NKTCMEGWMGPEC-------NRAICRQGCSPKHGS---CKLPGDCRCQYGWQGLYCDKCI 266

Query: 107 QE--CVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCD---PKSG 161
               CVHG C  P QC C   W G  C  +         C     C N  +C    P   
Sbjct: 267 PHPGCVHGICNEPWQCLCETNWGGQLCDKDL------NYCGTHQPCLNGGTCSNTGPDKY 320

Query: 162 VCSCPSGLQPPNC--------LQP-----------------CTPGYYGPACQFRCQ---- 192
            CSCP G   PNC          P                 C+PG+ GP C         
Sbjct: 321 QCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSP 380

Query: 193 ---CHGAPCDPQTGA--CFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGS 247
               HG  C        C CP + TG +C +  ++      C +  SC+N          
Sbjct: 381 NNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANE-CEAKPCVNAKSCKN----LIASYY 435

Query: 248 CSCPPGWMGTICSLPCPEGFHGPNCSQEC--RCHNGGLC-DRFTG-QCRCAPGYTGDRCR 303
           C C PGWMG  C +             +C  +C N   C D   G +C C PGY GD C 
Sbjct: 436 CDCLPGWMGQNCDINI----------NDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCE 485

Query: 304 ---EECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTG-------DRCTDRLCPDG 353
              +EC        C     C  +   F     CLC  GF+G       D C    C +G
Sbjct: 486 RDIDECA----SNPCLNGGHCQNEINRF----QCLCPTGFSGNLCQLDIDYCEPNPCQNG 537

Query: 354 --FYGLSCQAPCTCDREH-SLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQ--EHC 408
              Y  +    C C  ++   +C  +   C   P      C  +   +    G +     
Sbjct: 538 AQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSN 597

Query: 409 LCLHGGVCQATSG---LCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDG- 464
           +C   G C++ SG    C C  G+TG +C          +N      C N   C  IDG 
Sbjct: 598 VCGPHGKCKSQSGGKFTCDCNKGFTGTYCHE-------NINDCESNPCRNGGTC--IDGV 648

Query: 465 ---ECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTG--ACTCTPGWHGAH 519
              +C+C +GW+   C            C+ +  C +   C        C C  GW G  
Sbjct: 649 NSYKCICSDGWEGAYCETNIN------DCSQN-PCHNGGTCRDLVNDFYCDCKNGWKGKT 701

Query: 520 CQLPCPKGQFGEGCASRCD---CDHSDGC--DPVHGRCQCQAGWMGARCHLSCPEGLWGV 574
           C              S+CD   C++   C  +    +C C  GW G  C+++        
Sbjct: 702 C----------HSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIA-------- 743

Query: 575 NCSNTC---TCKNGGTCL--PENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSF 629
             +++C    C NGGTC+   E+  CVC  G+ GP C ++         C P  C N   
Sbjct: 744 -RNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTND------CSPHPCYNSGT 796

Query: 630 CHPSNG--TCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGS--CICPLG 685
           C   +    C C  G+ GPDC           N  Q+  C  G TC  +     C+CP G
Sbjct: 797 CVDGDNWYRCECAPGFAGPDC-------RININECQSSPCAFGATCVDEINGYRCVCPPG 849

Query: 686 WTGHHCLE--GCPLGTFGA----------NCSQPCQCGPGE------KCHPETGACVCPP 727
            +G  C E  G P  T G+          +C+  CQC  G        C P    C+   
Sbjct: 850 HSGAKCQEVSGRPCITMGSVIPDGAKWDDDCN-TCQCLNGRIACSKVWCGPR--PCLLHK 906

Query: 728 GHSGAP 733
           GHS  P
Sbjct: 907 GHSECP 912



 Score =  115 bits (288), Expect = 2e-25
 Identities = 95/338 (28%), Positives = 115/338 (34%), Gaps = 108/338 (31%)

Query: 479 VPCPPGTWGFSCNASCQCAHEAV---CSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCAS 535
           V C    +GF CN  C+   +        Q G  TC  GW G  C              +
Sbjct: 185 VTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPEC--------------N 230

Query: 536 RCDCDHSDGCDPVHGRCQ------CQAGWMGARC-----HLSCPEGL------------W 572
           R  C    GC P HG C+      CQ GW G  C     H  C  G+            W
Sbjct: 231 RAIC--RQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNW 288

Query: 573 GVN--------CSNTCTCKNGGTCL---PENGNCVCAPGFRGPSCQRSCQPGRYGKRCVP 621
           G          C     C NGGTC    P+   C C  G+ GP+C+ +         C+ 
Sbjct: 289 GGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIA------EHACLS 342

Query: 622 CKCANHSFCHPSN--GTCYCLAGWTGPDCS---QPCPPGHWGENCAQTCQCHHGGTCHP- 675
             C N   C  ++    C C  GWTGP CS     C P +          C HGGTC   
Sbjct: 343 DPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNN----------CSHGGTCQDL 392

Query: 676 -QDGSCICPLGWTGHHC-LEG------------------------CPLGTFGANCS---Q 706
                C+CP  WTG  C L+                         C  G  G NC     
Sbjct: 393 VNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININ 452

Query: 707 PC--QCGPGEKCHPETGA--CVCPPGHSGAPCRIGIQE 740
            C  QC     C        C+CPPG++G  C   I E
Sbjct: 453 DCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDE 490


>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
          Length = 1238

 Score =  209 bits (533), Expect = 8e-54
 Identities = 209/768 (27%), Positives = 266/768 (34%), Gaps = 204/768 (26%)

Query: 101 CVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSE-------------------------- 134
           CVP     CVHG CV P QC C   W G  C  +                          
Sbjct: 276 CVPYPG--CVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRC 333

Query: 135 -CAPGMWGPQCDK---PCS---CGNNSSCD--PKSGVCSCPSGLQPPNCLQPCTPGYYGP 185
            C  G  G  C+K    C+   C N  SC   P    C CPSG   P C          P
Sbjct: 334 TCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP 393

Query: 186 ACQFRCQCHGAPCDPQTG-ACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQN--GGVFQ 242
                C   G   D   G  C CP +  G +C +  ++   G  C +  SC+N  GG + 
Sbjct: 394 -----CAAGGTCVDQVDGFECICPEQWVGATCQLDANE-CEGKPCLNAFSCKNLIGGYY- 446

Query: 243 TPQGSCSCPPGWMGTICSL------------------------PCPEGFHGPNCS---QE 275
                C C PGW G  C +                         CP GF G +C     E
Sbjct: 447 -----CDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDE 501

Query: 276 CR---CHNGGLCDRFTG--QCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPA 330
           C    CH+GGLC+       C C  G++G  C  +        D  E   C   ARC+  
Sbjct: 502 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDV-------DLCEPSPCRNGARCYNL 554

Query: 331 NG--ACLCEHGFTGDRCT--DRLCPDGFYGLSCQAPCTCDRE---------HSLSCHPM- 376
            G   C C   F G  C+     CP G    +C+    C  +          S  C P  
Sbjct: 555 EGDYYCACPDDFGGKNCSVPREPCPGG----ACRVIDGCGSDAGPGMPGTAASGVCGPHG 610

Query: 377 --------NGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVC--QATSGLCQCA 426
                   N  C C  G+ G +C+E+       P       C +GG C  +  +  C C 
Sbjct: 611 RCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQP-------CRNGGTCIDEVDAFRCFCP 663

Query: 427 PGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTW 486
            G+ G  C    P D     C +R  C + +     D  C C +GW+   C       + 
Sbjct: 664 SGWEGELC-DTNPNDCLPDPCHSRGRCYDLVN----DFYCACDDGWKGKTCH------SR 712

Query: 487 GFSCNASCQCAHEAVC--SPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDG 544
            F C+A   C++   C  S  T  C C PGW G+ C +          C +   C  S  
Sbjct: 713 EFQCDA-YTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSG- 770

Query: 545 CDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENG--NCVCAPGFR 602
                  C C+ GW G  C           N  N   C NGG C+       C CAPGF 
Sbjct: 771 ---ASFSCICRDGWEGRTC-------THNTNDCNPLPCYNGGICVDGVNWFRCECAPGFA 820

Query: 603 GPSCQ---RSCQ--PGRYGKRCVPCKCANHSFCHPSNG-TCYCLAGWTGPDCSQ------ 650
           GP C+     CQ  P  YG  CV             NG  C C  G  GP C +      
Sbjct: 821 GPDCRINIDECQSSPCAYGATCV----------DEINGYRCSCPPGRAGPRCQEVIGFGR 870

Query: 651 -------PCPPG-HWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGA 702
                  P P G  W E+C  +C+C         DG   C   W G       P    G 
Sbjct: 871 SCWSRGTPFPHGSSWVEDC-NSCRC--------LDGRRDCSKVWCGWK-----PCLLAGQ 916

Query: 703 NCSQPCQCGPGEKC-HPETGACVCPPGHSGAPCRIGIQEPFTVMPTTP 749
             +   QC  G++C     G C+ PP  +   C  G +EP    P+TP
Sbjct: 917 PEALSAQCPLGQRCLEKAPGQCLRPPCEAWGEC--GAEEP----PSTP 958



 Score =  186 bits (472), Expect = 1e-46
 Identities = 207/764 (27%), Positives = 262/764 (34%), Gaps = 210/764 (27%)

Query: 87  RLQCCHGFYES--RGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQC 144
           R++C   +Y +    FC P       H  C       C+ GW G +C            C
Sbjct: 195 RVRCDENYYSATCNKFCRPR-NDFFGHYTCDQYGNKACMDGWMGKECKEAV--------C 245

Query: 145 DKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGA 204
            + C+  +     P  G C C  G Q   C   C P    P C      HG+  +P    
Sbjct: 246 KQGCNLLHGGCTVP--GECRCSYGWQGRFC-DECVP---YPGC-----VHGSCVEP--WQ 292

Query: 205 CFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGV---FQTPQGSCSCPPGWMGTIC-- 259
           C C     G  CD   +      +C S H C NGG     +  Q  C+CP G+ G  C  
Sbjct: 293 CNCETNWGGLLCDKDLN------YCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK 346

Query: 260 -----------------------SLPCPEGFHGPNCS---QECR---CHNGGLC-DRFTG 289
                                     CP G+ GP C+    EC    C  GG C D+  G
Sbjct: 347 AEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG 406

Query: 290 -QCRCAPGYTGDRCR---EECPVGRFGQDCAET-----------CDCAP---DARCFPAN 331
            +C C   + G  C+    EC     G+ C              CDC P      C    
Sbjct: 407 FECICPEQWVGATCQLDANECE----GKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINV 462

Query: 332 GAC--LCEHGFT------GDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCL 383
             C   C+HG T      G +C   +CP GF G  C+     D   S  CH   G C  L
Sbjct: 463 NDCRGQCQHGGTCKDLVNGYQC---VCPRGFGGRHCE--LERDECASSPCH-SGGLCEDL 516

Query: 384 PGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASL------ 437
               G HC+  CPQ   GP            +C+    LC+ +P   G  C +L      
Sbjct: 517 AD--GFHCH--CPQGFSGP------------LCEVDVDLCEPSPCRNGARCYNLEGDYYC 560

Query: 438 -CPPDTYGVNCSA-RCSCENAIACSPID----------------------GECVCKEGWQ 473
            CP D  G NCS  R  C    AC  ID                      G CV + G  
Sbjct: 561 ACPDDFGGKNCSVPREPCPGG-ACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG-- 617

Query: 474 RGNCSVPCPPGTWGFSCNASCQ------CAHEAVCSPQTGA--CTCTPGWHGAHCQLPCP 525
            GN S  C  G  G  C+ +        C +   C  +  A  C C  GW G  C    P
Sbjct: 618 -GNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTN-P 675

Query: 526 KGQFGEGCASRCDCDHSDGCDPVHG-RCQCQAGWMGARCH---LSCPEGLWGVNCSNTCT 581
                + C SR  C      D V+   C C  GW G  CH     C          +  T
Sbjct: 676 NDCLPDPCHSRGRC-----YDLVNDFYCACDDGWKGKTCHSREFQC----------DAYT 720

Query: 582 CKNGGTCLP--ENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNG--TC 637
           C NGGTC    +   C C PG++G +C  +         C+P  C N   C  S    +C
Sbjct: 721 CSNGGTCYDSGDTFRCACPPGWKGSTCAVA-----KNSSCLPNPCVNGGTCVGSGASFSC 775

Query: 638 YCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDG----SCICPLGWTGHHCLE 693
            C  GW G  C+          N      C++GG C   DG     C C  G+ G  C  
Sbjct: 776 ICRDGWEGRTCTH-------NTNDCNPLPCYNGGIC--VDGVNWFRCECAPGFAGPDC-- 824

Query: 694 GCPLGTFGANCSQPCQCGPGEKCHPETGA--CVCPPGHSGAPCR 735
                    +  Q   C  G  C  E     C CPPG +G  C+
Sbjct: 825 -----RINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 863


>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
          Length = 1200

 Score =  209 bits (532), Expect = 1e-53
 Identities = 203/738 (27%), Positives = 261/738 (35%), Gaps = 182/738 (24%)

Query: 101 CVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSC---D 157
           CVP     CVHG CV P QC C   W G  C  +         C     C N  +C   +
Sbjct: 276 CVPYPG--CVHGSCVEPWQCNCETNWGGLLCDKDL------NYCGSHHPCTNGGTCINAE 327

Query: 158 PKSGVCSCPSGLQPPNCLQ---PCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGP 214
           P    C+CP G    NC +    CT       C     CH  P   +   C CP+  +GP
Sbjct: 328 PDQYRCTCPDGYSGRNCEKAEHACTSN----PCANGGSCHEVPSGFE---CHCPSGWSGP 380

Query: 215 SCDVSCSQGTSGFFCPSTHSCQNGG--VFQTPQGSCSCPPGWMGTICSLP---------- 262
           +C +   +  S       + C  GG  V Q     C CP  W+G  C L           
Sbjct: 381 TCALDIDECAS-------NPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQH 433

Query: 263 --------------CPEGFHGPNCS---QECR---CHNGGLCDRFTG--QCRCAPGYTGD 300
                         CP GF G +C     EC    CH+GGLC+       C C  G++G 
Sbjct: 434 GGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGP 493

Query: 301 RCREECPVGRFGQDCAETCDCAPDARCFPANG--ACLCEHGFTGDRCT--DRLCPDGFYG 356
            C  +        D  E   C   ARC+   G   C C   F G  C+     CP G   
Sbjct: 494 LCEVDV-------DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGG--- 543

Query: 357 LSCQAPCTCDRE---------HSLSCHPM---------NGECSCLPGWAGLHCNESCPQD 398
            +C+    C  +          S  C P          N  C C  G+ G +C+E+    
Sbjct: 544 -ACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDC 602

Query: 399 THGPGCQEHCLCLHGGVC--QATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENA 456
              P       C +GG C  +  +  C C  G+ G  C    P D     C +R  C + 
Sbjct: 603 LGQP-------CRNGGTCIDEVDAFRCFCPSGWEGELC-DTNPNDCLPDPCHSRGRCYDL 654

Query: 457 IACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVC--SPQTGACTCTPG 514
           +     D  C C +GW+   C       +  F C+A   C++   C  S  T  C C PG
Sbjct: 655 VN----DFYCACDDGWKGKTCH------SREFQCDA-YTCSNGGTCYDSGDTFRCACPPG 703

Query: 515 WHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGV 574
           W G+ C +          C +   C  S         C C+ GW G  C           
Sbjct: 704 WKGSTCAVAKNSSCLPNPCVNGGTCVGSG----ASFSCICRDGWEGRTC-------THNT 752

Query: 575 NCSNTCTCKNGGTCLPENG--NCVCAPGFRGPSCQ---RSCQ--PGRYGKRCVPCKCANH 627
           N  N   C NGG C+       C CAPGF GP C+     CQ  P  YG  CV       
Sbjct: 753 NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCV------- 805

Query: 628 SFCHPSNG-TCYCLAGWTGPDCSQ-------------PCPPG-HWGENCAQTCQCHHGGT 672
                 NG  C C  G  GP C +             P P G  W E+C  +C+C     
Sbjct: 806 ---DEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDC-NSCRC----- 856

Query: 673 CHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKC-HPETGACVCPPGHSG 731
               DG   C   W G       P    G   +   QC  G++C     G C+ PP  + 
Sbjct: 857 ---LDGRRDCSKVWCGWK-----PCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAW 908

Query: 732 APCRIGIQEPFTVMPTTP 749
             C  G +EP    P+TP
Sbjct: 909 GEC--GAEEP----PSTP 920



 Score =  131 bits (330), Expect = 3e-30
 Identities = 134/486 (27%), Positives = 172/486 (35%), Gaps = 151/486 (31%)

Query: 350 CPDGFYGLSCQAPC----------TCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDT 399
           C + +Y  +C   C          TCD+          G  +C+ GW G  C E+     
Sbjct: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQY---------GNKACMDGWMGKECKEAV---- 244

Query: 400 HGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCP-PDTYGVNCSA--RCSCE-- 454
               C++ C  LHGG      G C+C+ G+ G  C    P P     +C    +C+CE  
Sbjct: 245 ----CKQGCNLLHGGC--TVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETN 298

Query: 455 -----------------------NAIACSPIDGECVCKEGWQRGNC--------SVPCPP 483
                                    I   P    C C +G+   NC        S PC  
Sbjct: 299 WGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCAN 358

Query: 484 G------TWGFSCN-----------------ASCQCAHEAVCSPQTGA--CTCTPGWHGA 518
           G        GF C+                 AS  CA    C  Q     C C   W GA
Sbjct: 359 GGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGA 418

Query: 519 HCQLPCPKGQFGEGCASRCDCDHSDGC-DPVHG-RCQCQAGWMGARCHLSCPEGLWGVNC 576
            CQL          C  R  C H   C D V+G +C C  G+ G  C L   E      C
Sbjct: 419 TCQLDV------NDC--RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDE------C 464

Query: 577 SNTCTCKNGGTC--LPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSN 634
           +++  C +GG C  L +  +C C  GF GP C+           C P  C N + C+   
Sbjct: 465 ASS-PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVD------LCEPSPCRNGARCYNLE 517

Query: 635 GTCYCLA--GWTGPDCS---QPCP---------------PGHWGENCAQTCQCHHGGTCH 674
           G  YC     + G +CS   +PCP               PG  G   +  C  H  G C 
Sbjct: 518 GDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPH--GRCV 575

Query: 675 PQDG---SCICPLGWTGHHCLEGCPLGTFGANC-SQPCQCGPGEKCHPETGA--CVCPPG 728
            Q G   SCIC  G+TG +C E         +C  QPC+   G  C  E  A  C CP G
Sbjct: 576 SQPGGNFSCICDSGFTGTYCHENID------DCLGQPCR--NGGTCIDEVDAFRCFCPSG 627

Query: 729 HSGAPC 734
             G  C
Sbjct: 628 WEGELC 633


>gi|21264602 laminin alpha 5 [Homo sapiens]
          Length = 3695

 Score =  204 bits (519), Expect = 3e-52
 Identities = 169/576 (29%), Positives = 211/576 (36%), Gaps = 126/576 (21%)

Query: 190 RCQCHGA--------PCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPST----HSCQN 237
           RC CHG         P DP    C C     G +CD  C       + P+T    + CQ+
Sbjct: 299 RCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQS 358

Query: 238 -------------------------GGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPN- 271
                                     G +Q       C     G  C    P  +  PN 
Sbjct: 359 CNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNH 418

Query: 272 ------CSQECRCHNG---GLCDRFTGQCRCAPGYTGDRCREECPVGRFG-QDCAET--- 318
                   + C C +    G C+  TG+C C P ++G+RC + C  G  G   C  T   
Sbjct: 419 PLDSPHVCRRCNCESDFTDGTCEDLTGRCYCRPNFSGERC-DVCAEGFTGFPSCYPTPSS 477

Query: 319 ----------------CDCAPDA------RCFPANGACLCEHGFTGDRCTDRLCPDGFYG 356
                           CDC+         R  P  G CLC+  F G  C   LC  GFYG
Sbjct: 478 SNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHC--ELCAPGFYG 535

Query: 357 LSCQAPCTCDREHSLS--CHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGG 414
             CQ PC C         C P  G+C C  G+ G  C+   P   H P CQ  C C   G
Sbjct: 536 PGCQ-PCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQL-CGCSPAG 593

Query: 415 VCQA---TSGLCQCAPGYTGPHCASLCPPDTYGV-NCSARCSCENAIACSPIDGE---CV 467
                   +G C C P + GPHC   C P  +G  NC A C+C+   A   + G    C 
Sbjct: 594 TLPEGCDEAGRCLCQPEFAGPHC-DRCRPGYHGFPNCQA-CTCDPRGALDQLCGAGGLCR 651

Query: 468 CKEGWQRGNCSVPCPPGTWGFSCNASCQCAHE----AVCSPQTGACTCTPGWHGAHCQLP 523
           C+ G+    C   C PG  GF     C C+ E    A C P++G C+C P   G  C   
Sbjct: 652 CRPGYTGTACQ-ECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDT- 709

Query: 524 CPKGQFGEGCASRCDCDHSDGCDPVHGR-------CQCQAGWMGARCHLSCPEGLWGVNC 576
           C  G +         C H  G  PV          C C+A   G  C   C  G WG++ 
Sbjct: 710 CVPGAYNFPYCEAGSC-HPAGLAPVDPALPEAQVPCMCRAHVEGPSCD-RCKPGFWGLSP 767

Query: 577 SNT-----CTCKNGGT------CLPENGNCVCAPGFRGPSCQRSCQPGRYGKR------C 619
           SN      C+C   GT      C P  G C C P   G +C  SC+ G +G        C
Sbjct: 768 SNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACA-SCKDGFFGLDQADYFGC 826

Query: 620 VPCKC----ANHSFCHPSNGTCYCLAGWTGPDCSQP 651
             C+C    A    C P  G C C     GP CS+P
Sbjct: 827 RSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEP 862



 Score =  182 bits (462), Expect = 1e-45
 Identities = 162/555 (29%), Positives = 202/555 (36%), Gaps = 163/555 (29%)

Query: 119 QCQCVPGWRGDDCSSECAPGM----WGP-------QCDKPCSC-GNNSSC--DPK----- 159
           QC C     G  C   C PG     W P       +C   C+C G+ + C  DP+     
Sbjct: 321 QCTCQHNTCGGTCD-RCCPGFNQQPWKPATANSANECQS-CNCYGHATDCYYDPEVDRRR 378

Query: 160 -----------SGVC-SCPSGLQPPNCLQPCTPGYY--------GPACQFRCQCHG---- 195
                       GVC  C       NC + C PG+Y         P    RC C      
Sbjct: 379 ASQSLDGTYQGGGVCIDCQHHTTGVNC-ERCLPGFYRSPNHPLDSPHVCRRCNCESDFTD 437

Query: 196 APCDPQTGACFCPAERTGPSCDVSCSQGTSGF-FCPSTHSCQNGGVFQT----------- 243
             C+  TG C+C    +G  CDV C++G +GF  C  T S  N    Q            
Sbjct: 438 GTCEDLTGRCYCRPNFSGERCDV-CAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDC 496

Query: 244 -------------PQ-GSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGL----CD 285
                        P+ G C C P + GT C L C  GF+GP C Q C+C + G+    CD
Sbjct: 497 SAAGTQGNACRKDPRVGRCLCKPNFQGTHCEL-CAPGFYGPGC-QPCQCSSPGVADDRCD 554

Query: 286 RFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDA-------------------- 325
             TGQCRC  G+ G  C + C  G F     + C C+P                      
Sbjct: 555 PDTGQCRCRVGFEGATC-DRCAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAG 613

Query: 326 ----RCFP------------------------ANGACLCEHGFTGDRCTDRLCPDGFYGL 357
               RC P                        A G C C  G+TG  C +  C  GF+G 
Sbjct: 614 PHCDRCRPGYHGFPNCQACTCDPRGALDQLCGAGGLCRCRPGYTGTACQE--CSPGFHGF 671

Query: 358 SCQAPCTCDREHSL--SCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGV 415
               PC C  E SL  +C P +G+CSC P   GL C+   P   + P C E   C   G+
Sbjct: 672 PSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYC-EAGSCHPAGL 730

Query: 416 CQATSGL------CQCAPGYTGPHCASLCPPDTYGVNCS-----ARCSCE------NAIA 458
                 L      C C     GP C   C P  +G++ S      RCSC+          
Sbjct: 731 APVDPALPEAQVPCMCRAHVEGPSC-DRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAE 789

Query: 459 CSPIDGECVCKEGWQRGNCSVPCPPGTWG------FSCNASCQC----AHEAVCSPQTGA 508
           C P  G+C CK     G     C  G +G      F C  SC+C    A    C P+TG 
Sbjct: 790 CQPGTGQCFCKP-HVCGQACASCKDGFFGLDQADYFGCR-SCRCDIGGALGQSCEPRTGV 847

Query: 509 CTCTPGWHGAHCQLP 523
           C C P   G  C  P
Sbjct: 848 CRCRPNTQGPTCSEP 862



 Score =  159 bits (403), Expect = 1e-38
 Identities = 137/478 (28%), Positives = 178/478 (37%), Gaps = 87/478 (18%)

Query: 316 AETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREH---SLS 372
           A+ CD       F     C C+H   G  C DR CP   +      P T +  +   S +
Sbjct: 306 ADACDAKDPTDPFRLQ--CTCQHNTCGGTC-DRCCPG--FNQQPWKPATANSANECQSCN 360

Query: 373 CHPMNGECSCLPGWAGLHCNESCPQDTHGPG----CQEHCLCLHGGVCQATSGLCQCAPG 428
           C+    +C   P       ++S      G G    CQ H     G  C+      +C PG
Sbjct: 361 CYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTT---GVNCE------RCLPG 411

Query: 429 YTGPHCASLCPPDTYGVNCSARCSCENAIA---CSPIDGECVCKEGWQRGNCSVPCPPGT 485
           +       L  P     +   RC+CE+      C  + G C C+  +    C V C  G 
Sbjct: 412 FYRSPNHPLDSP-----HVCRRCNCESDFTDGTCEDLTGRCYCRPNFSGERCDV-CAEGF 465

Query: 486 WGF------------------------SCNASCQCAHEAVC--SPQTGACTCTPGWHGAH 519
            GF                        +C+ S        C   P+ G C C P + G H
Sbjct: 466 TGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTH 525

Query: 520 CQLPCPKGQFGEGCASRCDCDH----SDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVN 575
           C+L C  G +G GC   C C       D CDP  G+C+C+ G+ GA C   C  G +   
Sbjct: 526 CEL-CAPGFYGPGCQP-CQCSSPGVADDRCDPDTGQCRCRVGFEGATCD-RCAPGYFHFP 582

Query: 576 CSNTCTCKNGGTCLPEN----GNCVCAPGFRGPSCQRSCQPGRYG-KRCVPCKC----AN 626
               C C   GT LPE     G C+C P F GP C R C+PG +G   C  C C    A 
Sbjct: 583 LCQLCGCSPAGT-LPEGCDEAGRCLCQPEFAGPHCDR-CRPGYHGFPNCQACTCDPRGAL 640

Query: 627 HSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGT----CHPQDGSCIC 682
              C  + G C C  G+TG  C Q C PG  G      C C   G+    C P+ G C C
Sbjct: 641 DQLC-GAGGLCRCRPGYTGTAC-QECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSC 698

Query: 683 PLGWTGHHCLEGCPLGTFG-----ANCSQPCQCGPGEKCHPETGA-CVCPPGHSGAPC 734
               TG  C + C  G +      A    P    P +   PE    C+C     G  C
Sbjct: 699 RPRVTGLRC-DTCVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSC 755



 Score =  145 bits (366), Expect = 2e-34
 Identities = 114/350 (32%), Positives = 143/350 (40%), Gaps = 73/350 (20%)

Query: 120  CQCVPGWRGDDCSSECAPGMWGP-------QCDKPCSC-GNNSSCDPKSGVC-SCPSGLQ 170
            C C   +RGD C  ECAPG +         +C  PC C G++  C P SGVC  C    +
Sbjct: 1831 CLCPASYRGDSC-QECAPGFYRDVKGLFLGRC-VPCQCHGHSDRCLPGSGVCVDCQHNTE 1888

Query: 171  PPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCP 230
              +C + C  G+             +  DP      CP   + PS               
Sbjct: 1889 GAHC-ERCQAGFV-----------SSRDDPSAPCVSCPCPLSVPS--------------- 1921

Query: 231  STHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGP----NCSQECRCHNGG---- 282
              ++   G V +  +  C C PG+ G  C    P  F  P    +  Q C C   G    
Sbjct: 1922 --NNFAEGCVLRGGRTQCLCKPGYAGASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNL 1979

Query: 283  ---LCDRFTGQCR-CAPGYTGDRCREECPVGRFGQ-----DCAETCDCAP--DARCFPAN 331
                CD  TG CR C    TG RC E C  G +G      +C   CDC P     C P +
Sbjct: 1980 LFSDCDPLTGACRGCLRHTTGPRC-EICAPGFYGNALLPGNCTR-CDCTPCGTEACDPHS 2037

Query: 332  GACLCEHGFTGDRCTDRLCPDGFYGL----SCQAPCTC-DREHSLSCHPMNGECSCLPGW 386
            G CLC+ G TG RC DR C +G +G      C+ PC C        CHP +G+C C PG 
Sbjct: 2038 GHCLCKAGVTGRRC-DR-CQEGHFGFDGCGGCR-PCACGPAAEGSECHPQSGQCHCRPGT 2094

Query: 387  AGLHCNESCPQDTHGP--GCQEHCLCLHGGVCQATSGLCQCAPGYTGPHC 434
             G  C E  P     P  GC+  C C  GG C   +G C C PG +G  C
Sbjct: 2095 MGPQCRECAPGYWGLPEQGCR-RCQC-PGGRCDPHTGRCNCPPGLSGERC 2142



 Score =  143 bits (361), Expect = 7e-34
 Identities = 106/329 (32%), Positives = 132/329 (40%), Gaps = 59/329 (17%)

Query: 414  GVCQATSGLCQCAPGYTGPHCASLCPPDTYG------VNCSARCSCE-NAIACSPIDGEC 466
            G   +   LC C   Y G  C   C P  Y       +     C C  ++  C P  G C
Sbjct: 1822 GALASNVELCLCPASYRGDSCQE-CAPGFYRDVKGLFLGRCVPCQCHGHSDRCLPGSGVC 1880

Query: 467  V-CKEGWQRGNCSVPCPPGTWGFSCNASCQC--------------AHEAVCSPQTGACTC 511
            V C+   +  +C   C  G      + S  C              A   V       C C
Sbjct: 1881 VDCQHNTEGAHCE-RCQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCLC 1939

Query: 512  TPGWHGAHCQLPCPKGQFGE-----GCASRCDCDHS-------DGCDPVHGRCQ-CQAGW 558
             PG+ GA C+  C  G FG           CDC  +         CDP+ G C+ C    
Sbjct: 1940 KPGYAGASCE-RCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHT 1998

Query: 559  MGARCHLSCPEGLWG-----VNCSNTCTCKNGGT--CLPENGNCVCAPGFRGPSCQRSCQ 611
             G RC + C  G +G      NC+  C C   GT  C P +G+C+C  G  G  C R CQ
Sbjct: 1999 TGPRCEI-CAPGFYGNALLPGNCTR-CDCTPCGTEACDPHSGHCLCKAGVTGRRCDR-CQ 2055

Query: 612  PGRYG----KRCVPCKC---ANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWG--ENCA 662
             G +G      C PC C   A  S CHP +G C+C  G  GP C + C PG+WG  E   
Sbjct: 2056 EGHFGFDGCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCRE-CAPGYWGLPEQGC 2114

Query: 663  QTCQCHHGGTCHPQDGSCICPLGWTGHHC 691
            + CQC  GG C P  G C CP G +G  C
Sbjct: 2115 RRCQC-PGGRCDPHTGRCNCPPGLSGERC 2142



 Score =  129 bits (324), Expect = 1e-29
 Identities = 111/418 (26%), Positives = 154/418 (36%), Gaps = 95/418 (22%)

Query: 369 HSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLH---GGVCQATSGLCQC 425
           +S+    + G C C  G A   C+   P D      +  C C H   GG C       +C
Sbjct: 289 YSIKDISIGGRCVC-HGHADA-CDAKDPTDPF----RLQCTCQHNTCGGTCD------RC 336

Query: 426 APGY-----------TGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQR 474
            PG+           +   C S C    +  +C      +   A   +DG       +Q 
Sbjct: 337 CPGFNQQPWKPATANSANECQS-CNCYGHATDCYYDPEVDRRRASQSLDGT------YQG 389

Query: 475 GNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCA 534
           G   + C   T G +C                    C PG++ +    P         C 
Sbjct: 390 GGVCIDCQHHTTGVNCER------------------CLPGFYRSPNH-PLDSPHVCRRC- 429

Query: 535 SRCDCDHSDG-CDPVHGRCQCQAGWMGARCHLSCPEGLWG-------------------- 573
             C+ D +DG C+ + GRC C+  + G RC + C EG  G                    
Sbjct: 430 -NCESDFTDGTCEDLTGRCYCRPNFSGERCDV-CAEGFTGFPSCYPTPSSSNDTREQVLP 487

Query: 574 ----VNCSNTCTCKNGGTCL--PENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANH 627
               VNC  +     G  C   P  G C+C P F+G  C+  C PG YG  C PC+C++ 
Sbjct: 488 AGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCEL-CAPGFYGPGCQPCQCSSP 546

Query: 628 SF----CHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHP---QDGSC 680
                 C P  G C C  G+ G  C + C PG++     Q C C   GT      + G C
Sbjct: 547 GVADDRCDPDTGQCRCRVGFEGATCDR-CAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRC 605

Query: 681 ICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGA---CVCPPGHSGAPCR 735
           +C   + G HC + C  G  G    Q C C P        GA   C C PG++G  C+
Sbjct: 606 LCQPEFAGPHC-DRCRPGYHGFPNCQACTCDPRGALDQLCGAGGLCRCRPGYTGTACQ 662



 Score =  121 bits (304), Expect = 3e-27
 Identities = 80/214 (37%), Positives = 96/214 (44%), Gaps = 37/214 (17%)

Query: 119  QCQCVPGWRGDDCSSECAPGMWG------PQCDKPCSCGNN-------SSCDPKSGVC-S 164
            QC C PG+ G  C   CAPG +G        C +PC C  N       S CDP +G C  
Sbjct: 1936 QCLCKPGYAGASCE-RCAPGFFGNPLVLGSSC-QPCDCSGNGDPNLLFSDCDPLTGACRG 1993

Query: 165  CPSGLQPPNCLQPCTPGYYG----PACQFRCQCHGA---PCDPQTGACFCPAERTGPSCD 217
            C      P C + C PG+YG    P    RC C       CDP +G C C A  TG  CD
Sbjct: 1994 CLRHTTGPRC-EICAPGFYGNALLPGNCTRCDCTPCGTEACDPHSGHCLCKAGVTGRRCD 2052

Query: 218  VSCSQGTSGFF-CPSTHSCQNGGVFQTPQ-----GSCSCPPGWMGTICSLPCPEGFHG-- 269
              C +G  GF  C     C  G   +  +     G C C PG MG  C   C  G+ G  
Sbjct: 2053 -RCQEGHFGFDGCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCR-ECAPGYWGLP 2110

Query: 270  -PNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRC 302
               C + C+C  GG CD  TG+C C PG +G+RC
Sbjct: 2111 EQGC-RRCQCP-GGRCDPHTGRCNCPPGLSGERC 2142



 Score =  112 bits (281), Expect = 1e-24
 Identities = 114/386 (29%), Positives = 142/386 (36%), Gaps = 122/386 (31%)

Query: 89   QCCHGFYESRGFCVPLCAQECVHGRCVAPNQC-----QCVPGWRGDDCSSECAPGMWGPQ 143
            +C  GFY           +    GRCV P QC     +C+PG        +C     G  
Sbjct: 1844 ECAPGFYRD--------VKGLFLGRCV-PCQCHGHSDRCLPG---SGVCVDCQHNTEGAH 1891

Query: 144  CDKPCSCGNNSSCD-PKSGVCSCPSGLQPPN---------------CLQPCTPGYYGPAC 187
            C++ C  G  SS D P +   SCP  L  P+               CL  C PGY G +C
Sbjct: 1892 CER-CQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCL--CKPGYAGASC 1948

Query: 188  Q-----------------FRCQCHG--------APCDPQTGAC-FCPAERTGPSCDVSCS 221
            +                   C C G        + CDP TGAC  C    TGP C++   
Sbjct: 1949 ERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEI--- 2005

Query: 222  QGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNG 281
                                        C PG+ G    LP        NC++ C C   
Sbjct: 2006 ----------------------------CAPGFYGN-ALLP-------GNCTR-CDCTPC 2028

Query: 282  G--LCDRFTGQCRCAPGYTGDRCREECPVGRFGQD-C--AETCDCAPDA---RCFPANGA 333
            G   CD  +G C C  G TG RC + C  G FG D C     C C P A    C P +G 
Sbjct: 2029 GTEACDPHSGHCLCKAGVTGRRC-DRCQEGHFGFDGCGGCRPCACGPAAEGSECHPQSGQ 2087

Query: 334  CLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNE 393
            C C  G  G +C  R C  G++GL  Q    C       C P  G C+C PG +G  C +
Sbjct: 2088 CHCRPGTMGPQC--RECAPGYWGLPEQGCRRCQCPGG-RCDPHTGRCNCPPGLSGERC-D 2143

Query: 394  SCPQDTHGP------GCQEHC-LCLH 412
            +C Q    P      G   HC +C H
Sbjct: 2144 TCSQQHQVPVPGGPVGHSIHCEVCDH 2169



 Score =  103 bits (256), Expect = 1e-21
 Identities = 68/204 (33%), Positives = 87/204 (42%), Gaps = 31/204 (15%)

Query: 146  KPCSC----GNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYG-PACQFRCQCHGAPCDP 200
            +PC C        +C+P  G C C + +   +C + C  GY+G P C+  C C    CD 
Sbjct: 1436 RPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSR-CATGYWGFPNCR-PCDCGARLCDE 1493

Query: 201  QTGACFCPAERTGPSCDVSCSQGTSGFF----CPSTHSCQNGGVFQ-------TPQGSCS 249
             TG C CP     P C + C   T G      C    +C   G+ +       T  G C 
Sbjct: 1494 LTGQCICPPRTIPPDC-LLCQPQTFGCHPLVGCEEC-NCSGPGIQELTDPTCDTDSGQCK 1551

Query: 250  CPPGWMGTICSLPCPEGFHG-PNCSQECRCHNG----GLCDRFTGQCRCAPGYTGDRCRE 304
            C P   G  C   C  GFHG P C + C CH      G+CD  TGQC C     G +C +
Sbjct: 1552 CRPNVTGRRCD-TCSPGFHGYPRC-RPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKC-D 1608

Query: 305  ECPVGRFGQDCAETCDCAPDARCF 328
            +C +G F  D A    C    RCF
Sbjct: 1609 QCSLGTFSLDAANPKGC---TRCF 1629



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 66/209 (31%), Positives = 78/209 (37%), Gaps = 32/209 (15%)

Query: 534  ASRCDCDHSDG-----CDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTC 588
            A  C C H  G     C+P  G+C C A  +G  C   C  G WG      C C     C
Sbjct: 1435 ARPCGC-HEVGATGPTCEPFGGQCPCHAHVIGRDCS-RCATGYWGFPNCRPCDC-GARLC 1491

Query: 589  LPENGNCVCAPGFRGPSCQRSCQPGRYGKR----CVPCKCANHSF-------CHPSNGTC 637
                G C+C P    P C   CQP  +G      C  C C+           C   +G C
Sbjct: 1492 DELTGQCICPPRTIPPDCLL-CQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDSGQC 1550

Query: 638  YCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGT----CHPQDGSCICPLGWTGHHCLE 693
             C    TG  C   C PG  G    + C CH  GT    C P  G C C     G  C +
Sbjct: 1551 KCRPNVTGRRCDT-CSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKC-D 1608

Query: 694  GCPLGTFGANCSQPCQC------GPGEKC 716
             C LGTF  + + P  C      G  E+C
Sbjct: 1609 QCSLGTFSLDAANPKGCTRCFCFGATERC 1637



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 73/242 (30%), Positives = 90/242 (37%), Gaps = 34/242 (14%)

Query: 191  CQCH-----GAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGG-VFQTP 244
            C CH     G  C+P  G C C A   G  C   C+ G  GF  P+   C  G  +    
Sbjct: 1438 CGCHEVGATGPTCEPFGGQCPCHAHVIGRDCS-RCATGYWGF--PNCRPCDCGARLCDEL 1494

Query: 245  QGSCSCPPGWMGTICSLPCPEGF--HGPNCSQECRCHNGGL-------CDRFTGQCRCAP 295
             G C CPP  +   C L  P+ F  H     +EC C   G+       CD  +GQC+C P
Sbjct: 1495 TGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDSGQCKCRP 1554

Query: 296  GYTGDRCREECPVGRFGQDCAETCDC-----APDARCFPANGACLCEHGFTGDRCTDRLC 350
              TG RC + C  G  G      CDC     AP   C P  G C C+    G +C    C
Sbjct: 1555 NVTGRRC-DTCSPGFHGYPRCRPCDCHEAGTAPGV-CDPLTGQCYCKENVQGPKCDQ--C 1610

Query: 351  PDGFYGLSCQAPCTCDR-------EHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPG 403
              G + L    P  C R       E   S      E   + GW  L  +         PG
Sbjct: 1611 SLGTFSLDAANPKGCTRCFCFGATERCRSSSYTRQEFVDMEGWVLLSTDRQVVPHERQPG 1670

Query: 404  CQ 405
             +
Sbjct: 1671 TE 1672



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 72/233 (30%), Positives = 90/233 (38%), Gaps = 55/233 (23%)

Query: 271  NCSQECRCHN----GGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDAR 326
            N ++ C CH     G  C+ F GQC C     G  C   C  G +G      CDC     
Sbjct: 1433 NGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDC-SRCATGYWGFPNCRPCDC----- 1486

Query: 327  CFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNG--ECSCLP 384
                 GA LC+   TG +C   +CP      +    C   +  +  CHP+ G  EC+C  
Sbjct: 1487 -----GARLCDE-LTG-QC---ICPPR----TIPPDCLLCQPQTFGCHPLVGCEECNC-- 1530

Query: 385  GWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYG 444
                            GPG QE    L    C   SG C+C P  TG  C   C P  +G
Sbjct: 1531 ---------------SGPGIQE----LTDPTCDTDSGQCKCRPNVTGRRC-DTCSPGFHG 1570

Query: 445  VNCSARCSCENA----IACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNAS 493
                  C C  A      C P+ G+C CKE  Q   C   C  GT  FS +A+
Sbjct: 1571 YPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCD-QCSLGT--FSLDAA 1620



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 62/211 (29%), Positives = 75/211 (35%), Gaps = 25/211 (11%)

Query: 446  NCSARCSCENAIA----CSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAV 501
            N +  C C    A    C P  G+C C       +CS  C  G WGF     C C    +
Sbjct: 1433 NGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCS-RCATGYWGFPNCRPCDCG-ARL 1490

Query: 502  CSPQTGACTCTPGWHGAHCQLPCPKGQFG----EGCASRCDCD-------HSDGCDPVHG 550
            C   TG C C P      C L C    FG     GC   C+C            CD   G
Sbjct: 1491 CDELTGQCICPPRTIPPDCLL-CQPQTFGCHPLVGC-EECNCSGPGIQELTDPTCDTDSG 1548

Query: 551  RCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGT----CLPENGNCVCAPGFRGPSC 606
            +C+C+    G RC  +C  G  G      C C   GT    C P  G C C    +GP C
Sbjct: 1549 QCKCRPNVTGRRCD-TCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKC 1607

Query: 607  QRSCQPGRYGKRCVPCKCANHSFCHPSNGTC 637
             + C  G +       K     FC  +   C
Sbjct: 1608 DQ-CSLGTFSLDAANPKGCTRCFCFGATERC 1637



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 69/229 (30%), Positives = 81/229 (35%), Gaps = 80/229 (34%)

Query: 114 CVAPNQCQCVPGWRGDDCSSECAPGMWG-PQCDKPCSCGNNSS----CDPKSGVCSC--- 165
           C A   C+C PG+ G  C  EC+PG  G P C  PC C    S    CDP+SG CSC   
Sbjct: 644 CGAGGLCRCRPGYTGTACQ-ECSPGFHGFPSC-VPCHCSAEGSLHAACDPRSGQCSCRPR 701

Query: 166 -------------------------PSGLQP--------------------PNCLQPCTP 180
                                    P+GL P                    P+C   C P
Sbjct: 702 VTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSC-DRCKP 760

Query: 181 GYYG-----PACQFRCQCH-------GAPCDPQTGACFCPAERTGPSCDVSCSQGTSG-- 226
           G++G     P    RC C         A C P TG CFC     G +C  SC  G  G  
Sbjct: 761 GFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQAC-ASCKDGFFGLD 819

Query: 227 ----FFCPSTHSCQNGGVF----QTPQGSCSCPPGWMGTICSLPCPEGF 267
               F C S   C  GG      +   G C C P   G  CS P  + +
Sbjct: 820 QADYFGCRSCR-CDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 867



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 60/193 (31%), Positives = 73/193 (37%), Gaps = 24/193 (12%)

Query: 494  CQCAHEA-----VCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPV 548
            C C HE       C P  G C C     G  C   C  G +G      CDC  +  CD +
Sbjct: 1438 CGC-HEVGATGPTCEPFGGQCPCHAHVIGRDCSR-CATGYWGFPNCRPCDCG-ARLCDEL 1494

Query: 549  HGRCQCQAGWMGARCHLSCPE--GLWGVNCSNTCTCKNGG-------TCLPENGNCVCAP 599
             G+C C    +   C L  P+  G   +     C C   G       TC  ++G C C P
Sbjct: 1495 TGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDSGQCKCRP 1554

Query: 600  GFRGPSCQRSCQPGRYG-KRCVPCKCANHS----FCHPSNGTCYCLAGWTGPDCSQPCPP 654
               G  C  +C PG +G  RC PC C         C P  G CYC     GP C Q C  
Sbjct: 1555 NVTGRRCD-TCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQ-CSL 1612

Query: 655  GHWGENCAQTCQC 667
            G +  + A    C
Sbjct: 1613 GTFSLDAANPKGC 1625



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 56/175 (32%), Positives = 65/175 (37%), Gaps = 63/175 (36%)

Query: 119  QCQCVPGWRGDDCSSECAPGMWG-PQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCL-- 175
            QC C     G DCS  CA G WG P C +PC CG    CD  +G C CP    PP+CL  
Sbjct: 1456 QCPCHAHVIGRDCS-RCATGYWGFPNC-RPCDCGARL-CDELTGQCICPPRTIPPDCLLC 1512

Query: 176  QP-------------------------------------------------CTPGYYG-P 185
            QP                                                 C+PG++G P
Sbjct: 1513 QPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYP 1572

Query: 186  ACQFRCQCHGAP-----CDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSC 235
             C+  C CH A      CDP TG C+C     GP CD  CS GT      +   C
Sbjct: 1573 RCR-PCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCD-QCSLGTFSLDAANPKGC 1625



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 57/180 (31%), Positives = 64/180 (35%), Gaps = 25/180 (13%)

Query: 575  NCSNTCTCKN----GGTCLPENGNCVCAPGFRGPSCQRSCQPGRYG-KRCVPCKCANHSF 629
            N +  C C      G TC P  G C C     G  C R C  G +G   C PC C     
Sbjct: 1433 NGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSR-CATGYWGFPNCRPCDCGAR-L 1490

Query: 630  CHPSNGTCYCLAGWTGPDCSQPCPPGHWGENC---AQTCQCHHGG-------TCHPQDGS 679
            C    G C C      PDC   C P  +G +     + C C   G       TC    G 
Sbjct: 1491 CDELTGQCICPPRTIPPDCLL-CQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDSGQ 1549

Query: 680  CICPLGWTGHHCLEGCPLGTFGANCSQPCQC-----GPGEKCHPETGACVCPPGHSGAPC 734
            C C    TG  C + C  G  G    +PC C      PG  C P TG C C     G  C
Sbjct: 1550 CKCRPNVTGRRC-DTCSPGFHGYPRCRPCDCHEAGTAPGV-CDPLTGQCYCKENVQGPKC 1607



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 56/245 (22%), Positives = 74/245 (30%), Gaps = 59/245 (24%)

Query: 533 CASRCD-CDHSDGCDPVHGRCQCQAGWMGARCHLSCP---EGLWGVNCSNTCTCKNGGTC 588
           C    D CD  D  DP   +C CQ    G  C   CP   +  W    +N+        C
Sbjct: 302 CHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCNC 361

Query: 589 LPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDC 648
                +C   P        +S   G Y    V   C +H+               TG +C
Sbjct: 362 YGHATDCYYDPEVDRRRASQSLD-GTYQGGGVCIDCQHHT---------------TGVNC 405

Query: 649 SQPCPPGHW--------GENCAQTCQCHHG---GTCHPQDGSCICPLGWTGHHCLEGCPL 697
            + C PG +          +  + C C      GTC    G C C   ++G  C + C  
Sbjct: 406 ER-CLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCRPNFSGERC-DVCAE 463

Query: 698 GTFGANCSQP--------------------CQCGP----GEKCH--PETGACVCPPGHSG 731
           G  G     P                    C C      G  C   P  G C+C P   G
Sbjct: 464 GFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQG 523

Query: 732 APCRI 736
             C +
Sbjct: 524 THCEL 528



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 31/91 (34%), Positives = 37/91 (40%), Gaps = 6/91 (6%)

Query: 660  NCAQTCQCHH----GGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEK 715
            N A+ C CH     G TC P  G C C     G  C   C  G +G    +PC CG    
Sbjct: 1433 NGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSR-CATGYWGFPNCRPCDCG-ARL 1490

Query: 716  CHPETGACVCPPGHSGAPCRIGIQEPFTVMP 746
            C   TG C+CPP      C +   + F   P
Sbjct: 1491 CDELTGQCICPPRTIPPDCLLCQPQTFGCHP 1521


>gi|145309306 scavenger receptor class F, member 1 isoform 5
           precursor [Homo sapiens]
          Length = 744

 Score =  192 bits (489), Expect = 1e-48
 Identities = 106/307 (34%), Positives = 135/307 (43%), Gaps = 48/307 (15%)

Query: 240 VFQTPQGSCSCPPGWM--GTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGY 297
           V  +P     C  GW      C++P  EG   P+      C    +C +  G CRC PG+
Sbjct: 31  VASSPSAELQCCAGWRQKDQECTIPICEG---PDA-----CQKDEVCVK-PGLCRCKPGF 81

Query: 298 TGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRL-------- 349
            G  C   CP   +G DC E+C C P  +C PA GAC C+    G RC            
Sbjct: 82  FGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRC 141

Query: 350 --------CPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCN-------ES 394
                   C  G++  +C+ PC C+   +  C    G C C PGW G  C+         
Sbjct: 142 DPATGVCHCEPGWWSSTCRRPCQCNTA-AARCEQATGACVCKPGWWGRRCSFRCNCHGSP 200

Query: 395 CPQDT---------HGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGV 445
           C QD+          GP CQ+ C C+ G  C A SG C C PG+ G  C   CP  ++GV
Sbjct: 201 CEQDSGRCACRPGWWGPECQQQCECVRGR-CSAASGECTCPPGFRGARCELPCPAGSHGV 259

Query: 446 NCSARCS-CENAIACSPIDGEC-VCKEGWQRGNCSVPCPPGTWGFSCNASC-QCAHEAVC 502
            C+  C  C++   CSP  G C  C+ GW    C  PC PGT+G SC   C  C H   C
Sbjct: 260 QCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEAC 319

Query: 503 SPQTGAC 509
            P TG C
Sbjct: 320 EPDTGHC 326



 Score =  190 bits (483), Expect = 5e-48
 Identities = 100/281 (35%), Positives = 125/281 (44%), Gaps = 41/281 (14%)

Query: 359 CQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQA 418
           C+ P  C ++  +   P  G C C PG+ G HC+  CP    GP C+E C C   G C+ 
Sbjct: 57  CEGPDACQKDE-VCVKP--GLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEP 113

Query: 419 TSGLCQCA----------PGYTGPH--CASL-----CPPDTYGVNCSARCSCENAIA-CS 460
            +G CQC           P   GPH  C        C P  +   C   C C  A A C 
Sbjct: 114 ATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCE 173

Query: 461 PIDGECVCKEGWQRGNCSV----------------PCPPGTWGFSCNASCQCAHEAVCSP 504
              G CVCK GW    CS                  C PG WG  C   C+C     CS 
Sbjct: 174 QATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGR-CSA 232

Query: 505 QTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCD-CDHSDGCDPVHGRCQ-CQAGWMGAR 562
            +G CTC PG+ GA C+LPCP G  G  CA  C  C H++ C P  G C+ C+ GW G +
Sbjct: 233 ASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQ 292

Query: 563 CHLSCPEGLWGVNCSNTCT-CKNGGTCLPENGNCVCAPGFR 602
           C   C  G +G +C   C  C++G  C P+ G+C    G R
Sbjct: 293 CQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCSGSR 333



 Score =  189 bits (480), Expect = 1e-47
 Identities = 109/337 (32%), Positives = 138/337 (40%), Gaps = 78/337 (23%)

Query: 88  LQCCHGFYESRGFC-VPLCA--QECVHGR-CVAPNQCQCVPGWRGDDCSSECAPGMWGPQ 143
           LQCC G+ +    C +P+C     C     CV P  C+C PG+ G  CSS C    WGP 
Sbjct: 39  LQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPD 98

Query: 144 CDK------------------------------PCSCGNNSSCDPKSGVCSCPSGLQPPN 173
           C +                              PC+CG +  CDP +GVC C  G     
Sbjct: 99  CRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSST 158

Query: 174 CLQP------------------CTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPS 215
           C +P                  C PG++G  C FRC CHG+PC+  +G C C     GP 
Sbjct: 159 CRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPE 218

Query: 216 CDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQE 275
           C   C              C  G       G C+CPPG+ G  C LPCP G HG  C+  
Sbjct: 219 CQQQC-------------ECVRGRC-SAASGECTCPPGFRGARCELPCPAGSHGVQCAHS 264

Query: 276 C-RCHNGGLCDRFTGQCR-CAPGYTGDRCREECPVGRFGQDCAETC-DCAPDARCFPANG 332
           C RC +   C   TG C  C PG+ G +C++ C  G FG+ C + C  C     C P  G
Sbjct: 265 CGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTG 324

Query: 333 ACLCEHGFTGDRCTDRLCPD------GFYGLSCQAPC 363
            C      +G R T  +          F GL+C A C
Sbjct: 325 HC---QRCSGSRDTALIAGSLVPLLLLFLGLACCACC 358



 Score =  188 bits (477), Expect = 3e-47
 Identities = 105/307 (34%), Positives = 130/307 (42%), Gaps = 51/307 (16%)

Query: 457 IACSPIDGECVCKEGWQRGN--CSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPG 514
           +A SP   E  C  GW++ +  C++P         C     C  + VC  + G C C PG
Sbjct: 31  VASSP-SAELQCCAGWRQKDQECTIPI--------CEGPDACQKDEVCV-KPGLCRCKPG 80

Query: 515 WHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHL--------- 565
           + GAHC   CP   +G  C   C C     C+P  G CQCQA   GARC           
Sbjct: 81  FFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGR 140

Query: 566 --------SCPEGLWGVNCSNTCTCKNGGT-CLPENGNCVCAPGFRGPSC---------- 606
                    C  G W   C   C C      C    G CVC PG+ G  C          
Sbjct: 141 CDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSP 200

Query: 607 ------QRSCQPGRYGKRC-VPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGE 659
                 + +C+PG +G  C   C+C     C  ++G C C  G+ G  C  PCP G  G 
Sbjct: 201 CEQDSGRCACRPGWWGPECQQQCECV-RGRCSAASGECTCPPGFRGARCELPCPAGSHGV 259

Query: 660 NCAQTC-QCHHGGTCHPQDGSC-ICPLGWTGHHCLEGCPLGTFGANCSQPC-QCGPGEKC 716
            CA +C +C H   C P  GSC  C  GW G  C + C  GTFG +C Q C  C  GE C
Sbjct: 260 QCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEAC 319

Query: 717 HPETGAC 723
            P+TG C
Sbjct: 320 EPDTGHC 326



 Score =  186 bits (471), Expect = 1e-46
 Identities = 101/313 (32%), Positives = 129/313 (41%), Gaps = 46/313 (14%)

Query: 368 EHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAP 427
           +H       + E  C  GW          Q+   P C+    C    VC    GLC+C P
Sbjct: 27  QHVCVASSPSAELQCCAGW------RQKDQECTIPICEGPDACQKDEVC-VKPGLCRCKP 79

Query: 428 GYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVP------- 480
           G+ G HC+S CP   +G +C   C C     C P  G C C+       C  P       
Sbjct: 80  GFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHG 139

Query: 481 ----------CPPGTWGFSCNASCQCAHEAV-CSPQTGACTCTPGWHGAHC--------- 520
                     C PG W  +C   CQC   A  C   TGAC C PGW G  C         
Sbjct: 140 RCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGS 199

Query: 521 -------QLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWG 573
                  +  C  G +G  C  +C+C     C    G C C  G+ GARC L CP G  G
Sbjct: 200 PCEQDSGRCACRPGWWGPECQQQCECVRG-RCSAASGECTCPPGFRGARCELPCPAGSHG 258

Query: 574 VNCSNTC-TCKNGGTCLPENGNC-VCAPGFRGPSCQRSCQPGRYGKRC-VPC-KCANHSF 629
           V C+++C  CK+   C P+ G+C  C PG+ G  CQ+ C PG +G+ C   C  C +   
Sbjct: 259 VQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEA 318

Query: 630 CHPSNGTCYCLAG 642
           C P  G C   +G
Sbjct: 319 CEPDTGHCQRCSG 331



 Score =  151 bits (381), Expect = 4e-36
 Identities = 85/274 (31%), Positives = 104/274 (37%), Gaps = 60/274 (21%)

Query: 484 GTWGFSCNASCQCAHEAVCSPQTGACTCTPGWH--GAHCQLPCPKGQFGEGCASRCDCDH 541
           GT G   +   Q  H  V S  +    C  GW      C +P  +G          D   
Sbjct: 16  GTQGSELDPKGQ--HVCVASSPSAELQCCAGWRQKDQECTIPICEGP---------DACQ 64

Query: 542 SDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGF 601
            D      G C+C+ G+ GA C   CP   WG +C  +C C   G C P  G C      
Sbjct: 65  KDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGAC------ 118

Query: 602 RGPSCQRSCQPGRYGKRC-VPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCP------- 653
                   CQ  R+G RC  PC C  H  C P+ G C+C  GW    C +PC        
Sbjct: 119 -------QCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAAR 171

Query: 654 -----------PGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGA 702
                      PG WG  C+  C CH G  C    G C C  GW             +G 
Sbjct: 172 CEQATGACVCKPGWWGRRCSFRCNCH-GSPCEQDSGRCACRPGW-------------WGP 217

Query: 703 NCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRI 736
            C Q C+C  G +C   +G C CPPG  GA C +
Sbjct: 218 ECQQQCECVRG-RCSAASGECTCPPGFRGARCEL 250


>gi|122937283 6720455I24Rik homolog [Homo sapiens]
          Length = 1413

 Score =  188 bits (477), Expect = 3e-47
 Identities = 188/725 (25%), Positives = 249/725 (34%), Gaps = 201/725 (27%)

Query: 105 CAQECVHGRCVAPNQCQCVPGWRGDDCS---SECAPGMWGPQCDKPCSCGNNSSCDPKSG 161
           C  +CV G       C C+ G+ G  C    +ECA         +PC  G   +    S 
Sbjct: 284 CIDDCVTGN--PSYTCSCLSGFTGRRCHLDVNECA--------SQPCQNGGTCTHGINSF 333

Query: 162 VCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGA--CFCPAERTGPSCDVS 219
            C CP+G   P C    +P      C  +   HG  C  + G+  C C A  TG +C++ 
Sbjct: 334 RCQCPAGFGGPTCETAQSP------CDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMD 387

Query: 220 CSQGTSGFFCPSTHSCQNGG--VFQTPQGSCSCPPGWMGTICSLPCPEGFHG-PNCSQEC 276
                    C S   C NGG  V      +C C   + G    L C  G H  P+     
Sbjct: 388 VDD------C-SPDPCLNGGSCVDLVGNYTCLCAEPFKG----LRCETGDHPVPDACLSA 436

Query: 277 RCHNGGLC-DRFTGQ-CRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGA- 333
            CHNGG C D   G  C C  G+ G  CRE  P         + C+C    RC  AN   
Sbjct: 437 PCHNGGTCVDADQGYVCECPEGFMGLDCRERVP---------DDCECRNGGRCLGANTTL 487

Query: 334 CLCEHGFTGDRCTDRL----------CPDGFYGLSCQAP--CTCDREHSLSCHPMNGECS 381
           C C  GF G  C   +          CPDG Y +       C C  +H+ S H +   C 
Sbjct: 488 CQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNAS-HSLPSPCD 546

Query: 382 CLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQA--TSGLCQCAPGYTGPHCASLCP 439
             P                         C +GG C A   S  C+C  G+ G HC    P
Sbjct: 547 SDP-------------------------CFNGGSCDAHDDSYTCECPRGFHGKHCEKARP 581

Query: 440 PDTYGVNCSARCSCENAIACSPIDGE--CVCKEGWQRGNCSVPCPPGTWGFSCNASCQCA 497
                 +  +   C N   C    GE  C C   +   +C +  P      SC AS  C 
Sbjct: 582 ------HLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPD-----SC-ASGPCH 629

Query: 498 HEAVCSPQTG--ACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQ 555
           +   C    G   C C PG+ G HC++  P   F   C +   C+  D        C CQ
Sbjct: 630 NGGTCFHYIGKYKCDCPPGFSGRHCEI-APSPCFRSPCVNGGTCEDRD----TDFFCHCQ 684

Query: 556 AGWMGARC--HLSC------------------------------------------PEGL 571
           AG+MG RC   + C                                          P G+
Sbjct: 685 AGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGV 744

Query: 572 WG-------VNCSNTCTCKNGGTCLPENGN--CVCAPGFRGPSCQRSCQPGRYGKRCVPC 622
           W        ++   +  C +GG+C        C+C+ G+ G  C+      R   R  PC
Sbjct: 745 WSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELE----RDECRAHPC 800

Query: 623 KCANHSFCHPSNGTCYCLAGWTGPDC--------SQPCPPGHWGENCAQTCQCHHGGTCH 674
           +        P    C C AG+ G  C        S PC  G          +C  GG  +
Sbjct: 801 RNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGG---------RCESGGGAY 851

Query: 675 PQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPC---QCGPGEKCHPETG--ACVCPPGH 729
                C+CP  + G+HC             S PC    CG    C    G  +C C  G+
Sbjct: 852 ----LCVCPESFFGYHC----------ETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGY 897

Query: 730 SGAPC 734
           +G  C
Sbjct: 898 TGEDC 902



 Score =  147 bits (371), Expect = 5e-35
 Identities = 158/569 (27%), Positives = 203/569 (35%), Gaps = 123/569 (21%)

Query: 220 CSQGTSGFFCPSTHSCQNGG------VFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCS 273
           C   TS   C +   C NGG      V   P  +CSC  G+ G  C L   E    P   
Sbjct: 265 CGHTTS--VCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQP--- 319

Query: 274 QECRCHNGGLCDRFTG--QCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPAN 331
               C NGG C       +C+C  G+ G  C          Q   +T +C    +C   N
Sbjct: 320 ----CQNGGTCTHGINSFRCQCPAGFGGPTCET-------AQSPCDTKECQHGGQCQVEN 368

Query: 332 GA--CLCEHGFTGDRC---TDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGE--CSCLP 384
           G+  C+C+ G+TG  C    D   PD         PC     +  SC  + G   C C  
Sbjct: 369 GSAVCVCQAGYTGAACEMDVDDCSPD---------PCL----NGGSCVDLVGNYTCLCAE 415

Query: 385 GWAGLHCNESCPQDTHGPGCQEHCLCLHGGVC-QATSG-LCQCAPGYTGPHCASLCPPDT 442
            + GL C      D   P       C +GG C  A  G +C+C  G+ G  C    P D 
Sbjct: 416 PFKGLRCETG---DHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDD- 471

Query: 443 YGVNCSARCSCENAIACSPIDGE-CVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAV 501
                   C C N   C   +   C C  G+      + C        CN + QC     
Sbjct: 472 --------CECRNGGRCLGANTTLCQCPLGF----FGLLCEFEITAMPCNMNTQCPDGGY 519

Query: 502 CSPQTGA--CTCTPGWHGAHCQLPCPKGQFGEGCASRCDCD-HSDGCDPVHGRCQCQAGW 558
           C    G+  C C    + +H  LP P     + C +   CD H D        C+C  G+
Sbjct: 520 CMEHGGSYLCVCHTDHNASH-SLPSPCDS--DPCFNGGSCDAHDDSYT-----CECPRGF 571

Query: 559 MGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKR 618
            G  C  + P       C N  TCK  G       +C C   F G    R C+ G+    
Sbjct: 572 HGKHCEKARPHLCSSGPCRNGGTCKEAG----GEYHCSCPYRFTG----RHCEIGK---- 619

Query: 619 CVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENC---AQTC---QCHHGGT 672
             P  CA+   CH + GTC+   G    D    CPPG  G +C      C    C +GGT
Sbjct: 620 --PDSCASGP-CH-NGGTCFHYIGKYKCD----CPPGFSGRHCEIAPSPCFRSPCVNGGT 671

Query: 673 CHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPET--------GAC- 723
           C  +D    C            C  G  G  C     CGP E+    T        GA  
Sbjct: 672 CEDRDTDFFC-----------HCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVA 720

Query: 724 --VCPPGHS-GAPCRIGIQEPFTVMPTTP 749
              C  G+S  AP RI + +P  V    P
Sbjct: 721 LYACDRGYSLSAPSRIRVCQPHGVWSEPP 749



 Score =  100 bits (250), Expect = 5e-21
 Identities = 125/509 (24%), Positives = 160/509 (31%), Gaps = 183/509 (35%)

Query: 104 LCAQ-----ECVHGRCVAPNQCQCVPGWRGDDCSS-------ECAPGMWGPQCDK----P 147
           LCA+      C  G    P+ C   P   G  C         EC  G  G  C +     
Sbjct: 412 LCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDD 471

Query: 148 CSCGNNSSC-DPKSGVCSCPSGL-----------QPPNCLQPCTPGYY--GPACQFRCQC 193
           C C N   C    + +C CP G             P N    C  G Y       + C C
Sbjct: 472 CECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVC 531

Query: 194 HG---------APCDPQTGACF----CPAERTGPSCDVSCSQGTSGFFCP-------STH 233
           H          +PCD  +  CF    C A     +C+  C +G  G  C        S+ 
Sbjct: 532 HTDHNASHSLPSPCD--SDPCFNGGSCDAHDDSYTCE--CPRGFHGKHCEKARPHLCSSG 587

Query: 234 SCQNGGVFQTPQGS--CSCPPGWMGTICSLPCPEGF-HGPNCSQECRCHNGGLCDRFTGQ 290
            C+NGG  +   G   CSCP  + G  C +  P+    GP       CHNGG C  + G+
Sbjct: 588 PCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGP-------CHNGGTCFHYIGK 640

Query: 291 --CRCAPGYTGDRCRE-------------------------ECPVGRFGQDCAETCDCAP 323
             C C PG++G  C                            C  G  G+ C    DC P
Sbjct: 641 YKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGP 700

Query: 324 DARCFPA----NGACL-------CEHGFT------------------------------- 341
                 A    NG  L       C+ G++                               
Sbjct: 701 PEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQ 760

Query: 342 ----GDRCTDR------LCPDGFYGLSCQAPCTCDREHSL----SCHPMNGE--CSCLPG 385
               G  C DR      LC  G+ G  C+      R H      SC  + G   C C  G
Sbjct: 761 PCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAG 820

Query: 386 WAGLHCNES-------------------------CPQDTHGPGCQ---EHCL---CLHGG 414
           + G+HC                            CP+   G  C+   + C    C   G
Sbjct: 821 FVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRG 880

Query: 415 VCQATSGL--CQCAPGYTGPHCA-SLCPP 440
            C A++G   C C  GYTG  CA  L PP
Sbjct: 881 YCLASNGSHSCTCKVGYTGEDCAKELFPP 909



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 18/38 (47%), Positives = 25/38 (65%), Gaps = 3/38 (7%)

Query: 575  NCSNTCTCKNGGTCLP--ENGNCVCAPGFRGPSCQRSC 610
            NCS    C+NGGTC+P  +  +C C PGF+G  C+ +C
Sbjct: 1310 NCSEN-PCQNGGTCVPGADAHSCDCGPGFKGRRCELAC 1346



 Score = 35.0 bits (79), Expect = 0.37
 Identities = 21/70 (30%), Positives = 28/70 (40%), Gaps = 8/70 (11%)

Query: 271  NCSQECRCHNGGLC--DRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCF 328
            NCS+   C NGG C        C C PG+ G RC   C   +  + C        + + F
Sbjct: 1310 NCSEN-PCQNGGTCVPGADAHSCDCGPGFKGRRCELACI--KVSRPCTRLFS---ETKAF 1363

Query: 329  PANGACLCEH 338
            P     +C H
Sbjct: 1364 PVWEGGVCHH 1373



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 16/35 (45%), Positives = 18/35 (51%), Gaps = 2/35 (5%)

Query: 231  STHSCQNGG--VFQTPQGSCSCPPGWMGTICSLPC 263
            S + CQNGG  V      SC C PG+ G  C L C
Sbjct: 1312 SENPCQNGGTCVPGADAHSCDCGPGFKGRRCELAC 1346



 Score = 31.2 bits (69), Expect = 5.3
 Identities = 18/43 (41%), Positives = 22/43 (51%), Gaps = 7/43 (16%)

Query: 110  VHGRCVAPNQCQ----CVPGWRGDDCSSECAPGMWGPQCDKPC 148
            V G C + N CQ    CVPG   D  S +C PG  G +C+  C
Sbjct: 1307 VPGNC-SENPCQNGGTCVPG--ADAHSCDCGPGFKGRRCELAC 1346



 Score = 31.2 bits (69), Expect = 5.3
 Identities = 20/57 (35%), Positives = 24/57 (42%), Gaps = 13/57 (22%)

Query: 654  PGHWGENCAQTCQCHHGGTCHP--QDGSCICPLGWTGHHCLEGCPLGTFGANCSQPC 708
            PG+  EN      C +GGTC P     SC C  G+ G  C   C         S+PC
Sbjct: 1308 PGNCSEN-----PCQNGGTCVPGADAHSCDCGPGFKGRRCELAC------IKVSRPC 1353



 Score = 30.4 bits (67), Expect = 9.0
 Identities = 13/33 (39%), Positives = 16/33 (48%), Gaps = 2/33 (6%)

Query: 496  CAHEAVCSPQTGA--CTCTPGWHGAHCQLPCPK 526
            C +   C P   A  C C PG+ G  C+L C K
Sbjct: 1316 CQNGGTCVPGADAHSCDCGPGFKGRRCELACIK 1348


>gi|143770880 laminin, beta 4 [Homo sapiens]
          Length = 1761

 Score =  164 bits (415), Expect = 4e-40
 Identities = 135/419 (32%), Positives = 168/419 (40%), Gaps = 84/419 (20%)

Query: 276  CRCHN----GGLCDRFTGQCRCAPGYTGDRCREECPVGRF--GQDCAETCDCAP----DA 325
            C+CH     G  C R  GQC+C P   G RC + C  G +  G      C C P    D 
Sbjct: 769  CKCHPQGSVGSSCSRLGGQCQCKPLVVG-RCCDRCSTGSYDLGHHGCHPCHCHPQGSKDT 827

Query: 326  RCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPG 385
             C    G C C    +G RC DR C  G++G     PC C+R   L C P  G C    G
Sbjct: 828  VCDQVTGQCPCHGEVSGRRC-DR-CLAGYFGFPSCHPCPCNRFAEL-CDPETGSCFNCGG 884

Query: 386  WA-GLHCNESC-----PQDTHGPGCQEHCLC----------LHGGVCQATSG--LCQCAP 427
            +  G +C E C        + G  C+  CLC           H       S   +C C  
Sbjct: 885  FTTGRNC-ERCIDGYYGNPSSGQPCRP-CLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQ 942

Query: 428  GYTGPHCASLCP-----PDTYGVNCSARCSCENAI------ACSPIDGECV-CKEGWQRG 475
            GYTG  C          P   G  C   C+C N I      +CS + GEC+ C    Q  
Sbjct: 943  GYTGTQCGECSTGFYGNPRISGAPCQP-CACNNNIDVTDPESCSRVTGECLRCLHNTQGA 1001

Query: 476  NCSVPCPPGTWGFSCNASCQ-CAHEA---------------VCSPQTGACTCTPGWHGAH 519
            NC + C PG +G + N +C+ C+  A               +C P TGAC C P   G  
Sbjct: 1002 NCQL-CKPGHYGSALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLA 1060

Query: 520  CQLPCPKGQF----GEGCASRCDCD----HSDGCDPVHGRCQCQAGWMGARCHLSCPEGL 571
            C   C  G +    G GC S CDCD     S  CD + G+C C+ G+ G RC   C E  
Sbjct: 1061 CDR-CADGYWNLVPGRGCQS-CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCS-ECQENY 1117

Query: 572  WGVNCSN--TCTCKNGGT----CLPENGNCVCAPGFRGPSCQRSCQPGRYGK--RCVPC 622
            +G        C C   GT    C P+ G C C  G  G  C R C  G   +   C+ C
Sbjct: 1118 YGDPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDR-CARGHSQEFPTCLQC 1175



 Score =  123 bits (309), Expect = 8e-28
 Identities = 117/408 (28%), Positives = 144/408 (35%), Gaps = 85/408 (20%)

Query: 119  QCQCVPGWRGDDCSSECAPGMW--GPQCDKPCSCGNNSS----CDPKSGVCSCPSGLQPP 172
            QCQC P   G  C   C+ G +  G     PC C    S    CD  +G C C   +   
Sbjct: 787  QCQCKPLVVGR-CCDRCSTGSYDLGHHGCHPCHCHPQGSKDTVCDQVTGQCPCHGEVSGR 845

Query: 173  NCLQPCTPGYYG-PACQFRCQCH--GAPCDPQTGACF-CPAERTGPSCDVSCSQGTSGFF 228
             C   C  GY+G P+C   C C+     CDP+TG+CF C    TG +C+  C  G  G  
Sbjct: 846  RC-DRCLAGYFGFPSCH-PCPCNRFAELCDPETGSCFNCGGFTTGRNCE-RCIDGYYGN- 901

Query: 229  CPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFT 288
             PS+           P   C CP          P    +   +C Q     +        
Sbjct: 902  -PSSGQ---------PCRPCLCPDD--------PSSNQYFAHSCYQNLWSSDV------- 936

Query: 289  GQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDA-----------RCFPANGACL-C 336
              C C  GYTG +C E C  G +G        C P A            C    G CL C
Sbjct: 937  -ICNCLQGYTGTQCGE-CSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLRC 994

Query: 337  EHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLS--------------CHPMNGECSC 382
             H   G  C  +LC  G YG +    C     H+                C P+ G C C
Sbjct: 995  LHNTQGANC--QLCKPGHYGSALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPC 1052

Query: 383  LPGWAGLHCNESCP---QDTHGPGCQEHCLC----LHGGVCQATSGLCQCAPGYTGPHCA 435
            LP   GL C+           G GCQ  C C         C   +G C C  GY G  C 
Sbjct: 1053 LPNVTGLACDRCADGYWNLVPGRGCQS-CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRC- 1110

Query: 436  SLCPPDTYG------VNCSARCSCENAIACSPIDGECVCKEGWQRGNC 477
            S C  + YG      + C    +      C P  G C C+EG     C
Sbjct: 1111 SECQENYYGDPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRC 1158



 Score =  123 bits (308), Expect = 1e-27
 Identities = 109/399 (27%), Positives = 140/399 (35%), Gaps = 77/399 (19%)

Query: 404  CQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVN------CSARCSCENAI 457
            C+ H     G  C    G CQC P   G  C   C   +Y +       C          
Sbjct: 769  CKCHPQGSVGSSCSRLGGQCQCKPLVVG-RCCDRCSTGSYDLGHHGCHPCHCHPQGSKDT 827

Query: 458  ACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEA-VCSPQTGAC-TCTPGW 515
             C  + G+C C  G   G     C  G +GF     C C   A +C P+TG+C  C    
Sbjct: 828  VCDQVTGQCPC-HGEVSGRRCDRCLAGYFGFPSCHPCPCNRFAELCDPETGSCFNCGGFT 886

Query: 516  HGAHCQLPCPKGQFGEGCASR------CDCDHSDGCDPVHGR----------CQCQAGWM 559
             G +C+  C  G +G   + +      C  D S      H            C C  G+ 
Sbjct: 887  TGRNCER-CIDGYYGNPSSGQPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYT 945

Query: 560  GARCHLSCPEGLWG-----------VNCSNTCTCKNGGTCLPENGNCV-CAPGFRGPSCQ 607
            G +C   C  G +G             C+N     +  +C    G C+ C    +G +CQ
Sbjct: 946  GTQCG-ECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLRCLHNTQGANCQ 1004

Query: 608  RSCQPGRYG----KRCVPCKC-------------ANHSFCHPSNGTCYCLAGWTGPDCSQ 650
              C+PG YG    + C  C C                  C P  G C CL   TG  C +
Sbjct: 1005 L-CKPGHYGSALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDR 1063

Query: 651  PCPPGHW----GENCAQTCQCH----HGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFG- 701
             C  G+W    G  C Q+C C         C    G C C LG+ G  C E C    +G 
Sbjct: 1064 -CADGYWNLVPGRGC-QSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSE-CQENYYGD 1120

Query: 702  --ANCSQPCQCGPGEK----CHPETGACVCPPGHSGAPC 734
                C  PC C         C P+TG C C  G SG  C
Sbjct: 1121 PPGRCI-PCDCNRAGTQKPICDPDTGMCRCREGVSGQRC 1158



 Score =  101 bits (252), Expect = 3e-21
 Identities = 91/301 (30%), Positives = 118/301 (39%), Gaps = 62/301 (20%)

Query: 489  SCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFG---EGCASRCDCDHSDG- 544
            +C    Q +  + CS   G C C P   G  C   C  G +     GC   C C H  G 
Sbjct: 768  ACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDR-CSTGSYDLGHHGCHP-CHC-HPQGS 824

Query: 545  ----CDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKN-GGTCLPENGNCVCAP 599
                CD V G+C C     G RC   C  G +G    + C C      C PE G+C    
Sbjct: 825  KDTVCDQVTGQCPCHGEVSGRRCD-RCLAGYFGFPSCHPCPCNRFAELCDPETGSCFNCG 883

Query: 600  GFR-GPSCQRSCQPGRYG-----KRCVPCKC-----ANHSFCHP-------SNGTCYCLA 641
            GF  G +C+R C  G YG     + C PC C     +N  F H        S+  C CL 
Sbjct: 884  GFTTGRNCER-CIDGYYGNPSSGQPCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQ 942

Query: 642  GWTGPDCSQPCPPGHWGENC-----AQTCQCHHG------GTCHPQDGSCI-CPLGWTGH 689
            G+TG  C + C  G +G         Q C C++        +C    G C+ C     G 
Sbjct: 943  GYTGTQCGE-CSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLRCLHNTQGA 1001

Query: 690  HCLEGCPLGTFGANCSQPC-------------QCGPGEK---CHPETGACVCPPGHSGAP 733
            +C + C  G +G+  +Q C             +C PG     C P TGAC C P  +G  
Sbjct: 1002 NC-QLCKPGHYGSALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLA 1060

Query: 734  C 734
            C
Sbjct: 1061 C 1061



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 76/291 (26%), Positives = 100/291 (34%), Gaps = 59/291 (20%)

Query: 451 CSCE-NAIACSPID---GECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSP-- 504
           C C  +A  C P+    G+     G   G C   C   T G +C        +A   P  
Sbjct: 265 CFCNGHASECRPMQKMRGDVFSPPGMVHGQCV--CQHNTDGPNCERCKDFFQDAPWRPAA 322

Query: 505 --QTGAC-TCTPGWHGAHCQLPCP--------KGQFGEGCASRCDCDHSDGCDPVHGRCQ 553
             Q  AC +C+   H + C              G   E C    +  H D C P+  R  
Sbjct: 323 DLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDP 382

Query: 554 CQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPEN--------GNCVCAPGFRGPS 605
            +         +S P       C    T  +GG C+  +        G C+C     G  
Sbjct: 383 LKT--------ISDPYACIPCECDPDGTI-SGGICVSHSDPALGSVAGQCLCKENVEGAK 433

Query: 606 CQRSCQPGRYGKR------CVPCKC-----ANHSFCHPSNGTCYCLAGWTGPDCSQPCPP 654
           C + C+P  YG        C PC C          C    G C CL+  TG  C + C  
Sbjct: 434 CDQ-CKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEE-CTV 491

Query: 655 GHWG-----ENCAQTCQCHHGGT----CHPQDGSCICPLGWTGHHCLEGCP 696
           G+WG       C+  C C  GG     C P++G C C    TG  C E  P
Sbjct: 492 GYWGLGNHLHGCSP-CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAP 541



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 83/323 (25%), Positives = 109/323 (33%), Gaps = 62/323 (19%)

Query: 355 YGLSCQAPCTCDREHSLSCHPMN---GECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCL 411
           Y +  +  C C+  H+  C PM    G+    PG     C   C  +T GP C E C   
Sbjct: 257 YEMIVRGSCFCNG-HASECRPMQKMRGDVFSPPGMVHGQC--VCQHNTDGPNC-ERC--- 309

Query: 412 HGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEG 471
                       Q AP           P      N    CSC +  +    D       G
Sbjct: 310 --------KDFFQDAPWR---------PAADLQDNACRSCSCNSHSSRCHFDMTTYLASG 352

Query: 472 WQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGE 531
              G     C   T G  C+      +       +    C P      C+   P G    
Sbjct: 353 GLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIP------CECD-PDGTISG 405

Query: 532 G-CASRCDCDHSD-GCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNT-----CTCKN 584
           G C S     HSD     V G+C C+    GA+C   C    +G++ ++      C C  
Sbjct: 406 GICVS-----HSDPALGSVAGQCLCKENVEGAKCD-QCKPNHYGLSATDPLGCQPCDCNP 459

Query: 585 GG-----TCLPENGNCVCAPGFRGPSCQRSCQPGRYG-----KRCVPCKC----ANHSFC 630
            G     TC  + G C+C     G  C+  C  G +G       C PC C    A  + C
Sbjct: 460 LGSLPFLTCDVDTGQCLCLSYVTGAHCEE-CTVGYWGLGNHLHGCSPCDCDIGGAYSNVC 518

Query: 631 HPSNGTCYCLAGWTGPDCSQPCP 653
            P NG C C    TG  CS+P P
Sbjct: 519 SPKNGQCECRPHVTGRSCSEPAP 541



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 83/295 (28%), Positives = 100/295 (33%), Gaps = 75/295 (25%)

Query: 493 SCQC-AHEAVCSPQT---GACTCTPGWHGAHCQLPCPKGQFGEGCASRC-----DCDHSD 543
           SC C  H + C P     G     PG    H Q  C     G  C  RC     D     
Sbjct: 264 SCFCNGHASECRPMQKMRGDVFSPPGM--VHGQCVCQHNTDGPNC-ERCKDFFQDAPWRP 320

Query: 544 GCDPVHGRCQ-CQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFR 602
             D     C+ C      +RCH      L     S       GG C        C     
Sbjct: 321 AADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLS-------GGVCED------CQHNTE 367

Query: 603 GPSCQRSCQPGRYGK---------RCVPCKC-----------ANHSFCHPSNGT----CY 638
           G  C R C+P  Y            C+PC+C            +HS   P+ G+    C 
Sbjct: 368 GQHCDR-CRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHS--DPALGSVAGQCL 424

Query: 639 CLAGWTGPDCSQPCPPGHWGENCA-----QTCQCHHGG-----TCHPQDGSCICPLGWTG 688
           C     G  C Q C P H+G +       Q C C+  G     TC    G C+C    TG
Sbjct: 425 CKENVEGAKCDQ-CKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTG 483

Query: 689 HHCLEGCPLGTFGAN-----CSQPCQCGPG----EKCHPETGACVCPPGHSGAPC 734
            HC E C +G +G       CS PC C  G      C P+ G C C P  +G  C
Sbjct: 484 AHC-EECTVGYWGLGNHLHGCS-PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSC 536



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 64/257 (24%), Positives = 90/257 (35%), Gaps = 69/257 (26%)

Query: 331 NGACLCEHGFTGDRCTDRLCPDGFYGL-----------SCQAPCTCDREHSLSCHPMNGE 379
           +G C+C+H   G  C    C D F              +C++ C+C+  HS  CH     
Sbjct: 292 HGQCVCQHNTDGPNC--ERCKDFFQDAPWRPAADLQDNACRS-CSCN-SHSSRCHFDMTT 347

Query: 380 CSCLPGWAGLHCNESCPQDTHGPGCQE--------------------HCLC-----LHGG 414
                G +G  C E C  +T G  C                       C C     + GG
Sbjct: 348 YLASGGLSGGVC-EDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGG 406

Query: 415 VCQATS--------GLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENA---------- 456
           +C + S        G C C     G  C   C P+ YG++ +    C+            
Sbjct: 407 ICVSHSDPALGSVAGQCLCKENVEGAKCDQ-CKPNHYGLSATDPLGCQPCDCNPLGSLPF 465

Query: 457 IACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCN----ASCQC----AHEAVCSPQTGA 508
           + C    G+C+C       +C   C  G WG   +    + C C    A+  VCSP+ G 
Sbjct: 466 LTCDVDTGQCLCLSYVTGAHCE-ECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQ 524

Query: 509 CTCTPGWHGAHCQLPCP 525
           C C P   G  C  P P
Sbjct: 525 CECRPHVTGRSCSEPAP 541



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 80/268 (29%), Positives = 96/268 (35%), Gaps = 50/268 (18%)

Query: 110 VHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCD------KPCSCGNNSS-CDPKSGV 162
           VHG+CV  +      G   + C        W P  D      + CSC ++SS C      
Sbjct: 291 VHGQCVCQHNTD---GPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTT 347

Query: 163 CSCPSGLQPPNCLQPCTPGYYGPACQFRCQ--CHGAPCDPQTGACFC-PAERTGPSCDVS 219
                GL    C + C     G  C  RC+   +  P    +    C P E     CD  
Sbjct: 348 YLASGGLSGGVC-EDCQHNTEGQHCD-RCRPLFYRDPLKTISDPYACIPCE-----CD-- 398

Query: 220 CSQGT-SGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHG-----PNCS 273
              GT SG  C S      G V     G C C     G  C   C    +G     P   
Sbjct: 399 -PDGTISGGICVSHSDPALGSV----AGQCLCKENVEGAKCD-QCKPNHYGLSATDPLGC 452

Query: 274 QECRCHNGG-----LCDRFTGQCRCAPGYTGDRCREECPVGRFG-----QDCAETCDC-- 321
           Q C C+  G      CD  TGQC C    TG  C EEC VG +G       C+  CDC  
Sbjct: 453 QPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHC-EECTVGYWGLGNHLHGCSP-CDCDI 510

Query: 322 --APDARCFPANGACLCEHGFTGDRCTD 347
             A    C P NG C C    TG  C++
Sbjct: 511 GGAYSNVCSPKNGQCECRPHVTGRSCSE 538



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 44/132 (33%), Positives = 52/132 (39%), Gaps = 19/132 (14%)

Query: 120  CQCVPGWRGDDCSSECAPGMWG-------PQCDKPCSCGNNSSCDPKSGVCSCPSGLQPP 172
            C C+P   G  C   CA G W          CD       +S CD  +G C C  G    
Sbjct: 1050 CPCLPNVTGLACD-RCADGYWNLVPGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLGYGGK 1108

Query: 173  NCLQPCTPGYYG--PACQFRCQCHGAP-----CDPQTGACFCPAERTGPSCDVSCSQGTS 225
             C + C   YYG  P     C C+ A      CDP TG C C    +G  CD  C++G S
Sbjct: 1109 RCSE-CQENYYGDPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCD-RCARGHS 1166

Query: 226  GFF--CPSTHSC 235
              F  C   H C
Sbjct: 1167 QEFPTCLQCHLC 1178



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 45/160 (28%), Positives = 58/160 (36%), Gaps = 42/160 (26%)

Query: 147 PCSCGNN---------SSCDPK----SGVCSCPSGLQPPNCLQPCTPGYYGPA------C 187
           PC C  +         S  DP     +G C C   ++   C Q C P +YG +      C
Sbjct: 394 PCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQ-CKPNHYGLSATDPLGC 452

Query: 188 QFRCQCHGA------PCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTH-------S 234
           Q  C C+         CD  TG C C +  TG  C+    + T G++    H        
Sbjct: 453 Q-PCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCE----ECTVGYWGLGNHLHGCSPCD 507

Query: 235 CQNGGVFQT----PQGSCSCPPGWMGTICSLPCPEGFHGP 270
           C  GG +        G C C P   G  CS P P  F  P
Sbjct: 508 CDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAP 547



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 26/78 (33%), Positives = 34/78 (43%), Gaps = 12/78 (15%)

Query: 115 VAPNQCQCVPGWRGDDCSSECAPGMWG-----PQCDKPCSC----GNNSSCDPKSGVCSC 165
           V   QC C+    G  C  EC  G WG       C  PC C      ++ C PK+G C C
Sbjct: 470 VDTGQCLCLSYVTGAHCE-ECTVGYWGLGNHLHGCS-PCDCDIGGAYSNVCSPKNGQCEC 527

Query: 166 PSGLQPPNCLQPCTPGYY 183
              +   +C +P  PGY+
Sbjct: 528 RPHVTGRSCSEP-APGYF 544


>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
            sapiens]
          Length = 3118

 Score =  163 bits (412), Expect = 9e-40
 Identities = 143/488 (29%), Positives = 183/488 (37%), Gaps = 111/488 (22%)

Query: 120  CQCVPGWRGDDCSSECAPG-------MWGPQCDKPCSC-GNNSSCDPKSGVC-SCPSGLQ 170
            CQC PG+ G  C S C P        ++G  C+ PC C G+  SCD  +G C +C     
Sbjct: 724  CQCPPGYTGSSCES-CWPRHRRVNGTIFGGICE-PCQCFGHAESCDDVTGECLNCKDHTG 781

Query: 171  PPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCP 230
             P C   C PG+YG   +   +     C P       P+    P+C +  S G     C 
Sbjct: 782  GPYC-DKCLPGFYGEPTKGTSE----DCQPCACPLNIPSNNFSPTCHLDRSLG---LICD 833

Query: 231  STHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGP-----NCSQECRCHNG---- 281
                               CP G+ G  C   C EG+ G         Q C+C++     
Sbjct: 834  G------------------CPVGYTGPRCER-CAEGYFGQPSVPGGSCQPCQCNDNLDFS 874

Query: 282  --GLCDRFTGQCR-CAPGYTGDRCREECPVGRFGQDCAETCDCAP---------DARCFP 329
              G CD  +G C  C PG TG  C E C  G FG D  +  +C P            C  
Sbjct: 875  IPGSCDSLSGSCLICKPGTTGRYC-ELCADGYFG-DAVDAKNCQPCRCNAGGSFSEVCHS 932

Query: 330  ANGACLCEHGFTGDRCTDRLCPDGFYGLSCQ---APCTCDR--EHSLSCHPMNGECSCLP 384
              G C C     G RC    C  G +GL       PC C+     S  C   +G+C C P
Sbjct: 933  QTGQCECRANVQGQRCDK--CKAGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQP 989

Query: 385  GWAGLHCNESCPQDTHG------PGCQEHCLCLH-GGVCQATSGLCQCAPGYTGPHCASL 437
            G  G    + C +  HG       GC   C C H G  C   +G C C P   G  C S 
Sbjct: 990  GVTG----KKCDRCAHGYFNFQEGGCTA-CECSHLGNNCDPKTGRCICPPNTIGEKC-SK 1043

Query: 438  CPPDTYGVNCSARCSCENAIACSPID-------GECVCKEGWQRGNCSVPCPPGTWGFSC 490
            C P+T+G + +  C   N      +D       G+C C   +    C+  C  G W +  
Sbjct: 1044 CAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCT-ECSRGHWNYPR 1102

Query: 491  NASCQC-------------AHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFG------E 531
               C C               +  CS QTG CTC     G HC   C  G+FG       
Sbjct: 1103 CNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCD-RCRPGKFGLDAKNPL 1161

Query: 532  GCASRCDC 539
            GC+S C C
Sbjct: 1162 GCSS-CYC 1168



 Score =  163 bits (412), Expect = 9e-40
 Identities = 143/487 (29%), Positives = 183/487 (37%), Gaps = 114/487 (23%)

Query: 291  CRCAPGYTGDRCREECPVGR------FGQDCAETCDCAPDAR-CFPANGACLCEHGFTGD 343
            C+C PGYTG  C    P  R      FG  C E C C   A  C    G CL     TG 
Sbjct: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGIC-EPCQCFGHAESCDDVTGECLNCKDHTGG 782

Query: 344  RCTDRLCPDGFYGL-------SCQAPCTC-----DREHSLSCHPMNGECSCLPGWAGLHC 391
               D+  P GFYG         CQ PC C         S +CH        L    GL C
Sbjct: 783  PYCDKCLP-GFYGEPTKGTSEDCQ-PCACPLNIPSNNFSPTCH--------LDRSLGLIC 832

Query: 392  NESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARC 451
             + CP    GP C+                  +CA GY G        P   G +C   C
Sbjct: 833  -DGCPVGYTGPRCE------------------RCAEGYFGQ-------PSVPGGSCQP-C 865

Query: 452  SCENAI------ACSPIDGEC-VCKEGWQRGNCSVPCPPGTWGFSCNAS----CQC---- 496
             C + +      +C  + G C +CK G     C + C  G +G + +A     C+C    
Sbjct: 866  QCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL-CADGYFGDAVDAKNCQPCRCNAGG 924

Query: 497  AHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFG----EGCASRCDCDH----SDGCDPV 548
            +   VC  QTG C C     G  C   C  G FG     GC   C+C+     S  C+  
Sbjct: 925  SFSEVCHSQTGQCECRANVQGQRCD-KCKAGTFGLQSARGCVP-CNCNSFGSKSFDCEE- 981

Query: 549  HGRCQCQAGWMGARCHLSCPEGLWGVN---CSNTCTCKN-GGTCLPENGNCVCAPGFRGP 604
             G+C CQ G  G +C   C  G +      C+  C C + G  C P+ G C+C P   G 
Sbjct: 982  SGQCWCQPGVTGKKCD-RCAHGYFNFQEGGCT-ACECSHLGNNCDPKTGRCICPPNTIGE 1039

Query: 605  SCQRSCQPGRYGKR----CVPCKCANHSF----CHPSNGTCYCLAGWTGPDCSQPCPPGH 656
             C + C P  +G      C  C C+        C+ + G C C   ++G  C++ C  GH
Sbjct: 1040 KCSK-CAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTE-CSRGH 1097

Query: 657  WGENCAQTCQCHHGGT-------------CHPQDGSCICPLGWTGHHCLEGCPLGTFGAN 703
            W       C C   GT             C  Q G C C +   G HC + C  G FG +
Sbjct: 1098 WNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHC-DRCRPGKFGLD 1156

Query: 704  CSQPCQC 710
               P  C
Sbjct: 1157 AKNPLGC 1163



 Score =  147 bits (370), Expect = 7e-35
 Identities = 115/384 (29%), Positives = 158/384 (41%), Gaps = 71/384 (18%)

Query: 414  GVCQATSGLCQCAPGYTGPHCASLCPPDT------YGVNCSARCSC-ENAIACSPIDGEC 466
            G   A   +CQC PGYTG  C S  P         +G  C   C C  +A +C  + GEC
Sbjct: 715  GSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEP-CQCFGHAESCDDVTGEC 773

Query: 467  V-CKEGWQRGNCSVPCPPGTWGFSCNAS------CQCAHEAVCSPQTGACT--------- 510
            + CK+      C   C PG +G     +      C C      +  +  C          
Sbjct: 774  LNCKDHTGGPYCD-KCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLIC 832

Query: 511  --CTPGWHGAHCQLPCPKGQFGE-----GCASRCDCDHS------DGCDPVHGRCQ-CQA 556
              C  G+ G  C+  C +G FG+     G    C C+ +        CD + G C  C+ 
Sbjct: 833  DGCPVGYTGPRCER-CAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKP 891

Query: 557  GWMGARCHLSCPEGLWG-----VNCSNTCTCKNGGT----CLPENGNCVCAPGFRGPSCQ 607
            G  G  C L C +G +G      NC   C C  GG+    C  + G C C    +G  C 
Sbjct: 892  GTTGRYCEL-CADGYFGDAVDAKNCQ-PCRCNAGGSFSEVCHSQTGQCECRANVQGQRCD 949

Query: 608  RSCQPGRYG----KRCVPCKC---ANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWG-- 658
            + C+ G +G    + CVPC C    + SF    +G C+C  G TG  C + C  G++   
Sbjct: 950  K-CKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDR-CAHGYFNFQ 1007

Query: 659  ENCAQTCQCHH-GGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCS---QPCQCGP-- 712
            E     C+C H G  C P+ G CICP    G  C + C   T+G + +   + C C    
Sbjct: 1008 EGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSK-CAPNTWGHSITTGCKACNCSTVG 1066

Query: 713  --GEKCHPETGACVCPPGHSGAPC 734
                +C+  TG C C P  SGA C
Sbjct: 1067 SLDFQCNVNTGQCNCHPKFSGAKC 1090



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 80/286 (27%), Positives = 104/286 (36%), Gaps = 68/286 (23%)

Query: 119  QCQCVPGWRGDDCSSECAPGMWGPQCDK---PCSC---GNNSSCDPKSGVCSCPSGLQPP 172
            QC+C    +G  C  +C  G +G Q  +   PC+C   G+ S    +SG C C  G+   
Sbjct: 936  QCECRANVQGQRCD-KCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGK 994

Query: 173  NCLQPCTPGYY----GPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFF 228
             C   C  GY+    G      C   G  CDP+TG C CP    G  C   C+  T G  
Sbjct: 995  KC-DRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCS-KCAPNTWG-- 1050

Query: 229  CPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFT 288
                HS   G        +C+C      T+ SL                      C+  T
Sbjct: 1051 ----HSITTG------CKACNC-----STVGSLDFQ-------------------CNVNT 1076

Query: 289  GQCRCAPGYTGDRCREECPVGRFGQDCAETCDC-------------APDARCFPANGACL 335
            GQC C P ++G +C  EC  G +       CDC                  C    G C 
Sbjct: 1077 GQCNCHPKFSGAKC-TECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCT 1135

Query: 336  CEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECS 381
            C+    G  C DR C  G +GL  + P  C    S  C     +CS
Sbjct: 1136 CKVNVEGIHC-DR-CRPGKFGLDAKNPLGCS---SCYCFGTTTQCS 1176



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 64/207 (30%), Positives = 81/207 (39%), Gaps = 47/207 (22%)

Query: 571 LWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGR-------YGKRCVPCK 623
           L  VN  +  +    G+       C C PG+ G SC+ SC P         +G  C PC+
Sbjct: 700 LSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCE-SCWPRHRRVNGTIFGGICEPCQ 758

Query: 624 CANHS-FCHPSNGTCYCLAGWTGPDCSQPCPPGHWGE------NCAQTCQC-------HH 669
           C  H+  C    G C      TG      C PG +GE         Q C C       + 
Sbjct: 759 CFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNF 818

Query: 670 GGTCHPQ-------DGSCICPLGWTGHHCLEGCPLGTFG-----ANCSQPCQCG------ 711
             TCH         DG   CP+G+TG  C E C  G FG         QPCQC       
Sbjct: 819 SPTCHLDRSLGLICDG---CPVGYTGPRC-ERCAEGYFGQPSVPGGSCQPCQCNDNLDFS 874

Query: 712 -PGEKCHPETGAC-VCPPGHSGAPCRI 736
            PG  C   +G+C +C PG +G  C +
Sbjct: 875 IPG-SCDSLSGSCLICKPGTTGRYCEL 900



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 55/180 (30%), Positives = 70/180 (38%), Gaps = 42/180 (23%)

Query: 595  CVCAPGFRGPSCQRSCQPGRYGKR--------------CVPCKCANHS-FCHPSNGTCYC 639
            C C  G+ G SC+ +C PG Y  R              CVPC+C  HS  C P    C  
Sbjct: 1380 CDCPLGYSGLSCE-ACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438

Query: 640  LAGWTGPDCSQPCPPGHWG-----ENCAQTCQCHHGGTCHPQDGSCI-----------CP 683
                T  D  + C  G++G      N  Q C C    + +    SC+           CP
Sbjct: 1439 CQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACP 1498

Query: 684  LGWTGHHCLEGCP-----LGTFGANCSQPCQCGPGEK----CHPETGACVCPPGHSGAPC 734
             G+ G +C    P      G  G +C Q C+C P       C P TG C C PG +G  C
Sbjct: 1499 RGYEGQYCERCAPGYTGSPGNPGGSC-QECECDPYGSLPVPCDPVTGFCTCRPGATGRKC 1557



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 76/285 (26%), Positives = 111/285 (38%), Gaps = 67/285 (23%)

Query: 53   EPCERPWEGPHTCPQPTVVYRTVYRQ----VVKTDHRQRLQCCHGFY--ESRGFCVPLCA 106
            E  E+ W+     P+   V+RTV R+    ++   H   ++  +G +  +SR   + +  
Sbjct: 1305 EMTEKEWKYYGDDPR---VHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEV 1361

Query: 107  QECVHGRCVAP-----NQCQCVPGWRGDDCSSECAPGMW-----------GPQCDK--PC 148
             E   G  + P      +C C  G+ G  C + C PG +           GP      PC
Sbjct: 1362 AEQGRGTTMTPPADLIEKCDCPLGYSGLSCEA-CLPGFYRLRSQPGGRTPGPTLGTCVPC 1420

Query: 149  SC-GNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFC 207
             C G++S CDP++ +C         +  + C  GYYG          G P D Q   C C
Sbjct: 1421 QCNGHSSLCDPETSICQNCQHHTAGDFCERCALGYYGIV-------KGLPNDCQQ--CAC 1471

Query: 208  PAERTGPSCDVSC-SQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCP-- 264
            P   +  +   SC ++G   + C +                  CP G+ G  C    P  
Sbjct: 1472 PLISSSNNFSPSCVAEGLDDYRCTA------------------CPRGYEGQYCERCAPGY 1513

Query: 265  ---EGFHGPNCSQECRCHNGGL----CDRFTGQCRCAPGYTGDRC 302
                G  G +C QEC C   G     CD  TG C C PG TG +C
Sbjct: 1514 TGSPGNPGGSC-QECECDPYGSLPVPCDPVTGFCTCRPGATGRKC 1557



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 73/239 (30%), Positives = 87/239 (36%), Gaps = 69/239 (28%)

Query: 163  CSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPS--CDVSC 220
            C CP G    +C + C PG+Y    + R Q  G    P  G C  P +  G S  CD   
Sbjct: 1380 CDCPLGYSGLSC-EACLPGFY----RLRSQPGGRTPGPTLGTCV-PCQCNGHSSLCD--- 1430

Query: 221  SQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHG-----PNCSQE 275
                     P T  CQN            C     G  C   C  G++G     PN  Q+
Sbjct: 1431 ---------PETSICQN------------CQHHTAGDFCER-CALGYYGIVKGLPNDCQQ 1468

Query: 276  CRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACL 335
            C C      + F+  C  A G    RC   CP G  GQ C     CAP            
Sbjct: 1469 CACPLISSSNNFSPSC-VAEGLDDYRCTA-CPRGYEGQYCER---CAP------------ 1511

Query: 336  CEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLS--CHPMNGECSCLPGWAGLHCN 392
               G+TG          G  G SCQ  C CD   SL   C P+ G C+C PG  G  C+
Sbjct: 1512 ---GYTGS--------PGNPGGSCQE-CECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 65/252 (25%), Positives = 81/252 (32%), Gaps = 77/252 (30%)

Query: 350  CPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGP--GCQEH 407
            CP G+ GLSC+A                    CLPG+  L         T GP  G    
Sbjct: 1382 CPLGYSGLSCEA--------------------CLPGFYRLRSQPG--GRTPGPTLGTCVP 1419

Query: 408  CLCL-HGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGV-----NCSARCSCENAIACSP 461
            C C  H  +C   + +CQ    +T       C    YG+     N   +C+C    + + 
Sbjct: 1420 CQCNGHSSLCDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNN 1479

Query: 462  IDGECV-----------CKEGWQRGNCSVPCP-----PGTWGFSCNASCQC----AHEAV 501
                CV           C  G++   C    P     PG  G SC   C+C    +    
Sbjct: 1480 FSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQ-ECECDPYGSLPVP 1538

Query: 502  CSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGA 561
            C P TG CTC PG  G  C                      DGC   H R     GW   
Sbjct: 1539 CDPVTGFCTCRPGATGRKC----------------------DGCKHWHAR----EGWECV 1572

Query: 562  RCHLSCPEGLWG 573
             C   C   L G
Sbjct: 1573 FCGDECTGLLLG 1584



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 55/170 (32%), Positives = 66/170 (38%), Gaps = 47/170 (27%)

Query: 90   CCHGFYESR------------GFCVPLCAQECVHGRCVAPNQ--CQ-CVPGWRGDDCSSE 134
            C  GFY  R            G CVP   Q   H     P    CQ C     GD C   
Sbjct: 1394 CLPGFYRLRSQPGGRTPGPTLGTCVP--CQCNGHSSLCDPETSICQNCQHHTAGDFCE-R 1450

Query: 135  CAPGMWG-----PQCDKPCSCGNNSSCDPKSGVC-----------SCPSGLQPPNCLQPC 178
            CA G +G     P   + C+C   SS +  S  C           +CP G +   C + C
Sbjct: 1451 CALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYC-ERC 1509

Query: 179  TPGYYGP------ACQFRCQC--HGA---PCDPQTGACFCPAERTGPSCD 217
             PGY G       +CQ  C+C  +G+   PCDP TG C C    TG  CD
Sbjct: 1510 APGYTGSPGNPGGSCQ-ECECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 70/270 (25%), Positives = 89/270 (32%), Gaps = 98/270 (36%)

Query: 290 QCRCAPGYTGDRCREECP--------VGRF--GQDCAETCDCAPDAR-CFP--------- 329
           +C C     GD C + CP         G F    +C E C+C   A  C+          
Sbjct: 306 RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTEC-EACNCHGKAEECYYDENVARRNL 364

Query: 330 ---------ANGACL-CEHGFTGDRCTDRLCPDGFY---GLS------CQAPCTCDREHS 370
                      G C+ C     G  C    C DGF+   G+S      CQ PC CD   S
Sbjct: 365 SLNIRGKYIGGGVCINCTQNTAGINC--ETCTDGFFRPKGVSPNYPRPCQ-PCHCDPIGS 421

Query: 371 LS--C-----HPMNG----ECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQAT 419
           L+  C     H   G     C C  G+ G+ C+                           
Sbjct: 422 LNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCD--------------------------- 454

Query: 420 SGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSV 479
               +CA GYTG        PD    NCS   S        P  G C+CKE  + G+CS 
Sbjct: 455 ----RCARGYTG-------YPDCKACNCSGLGSKNE----DPCFGPCICKENVEGGDCS- 498

Query: 480 PCPPGTWGFSCNASCQCAHEAVCSPQTGAC 509
            C  G +    +    C  E  CS  +  C
Sbjct: 499 RCKSGFFNLQEDNWKGC-DECFCSGVSNRC 527



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 60/231 (25%), Positives = 74/231 (32%), Gaps = 67/231 (29%)

Query: 423  CQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCP 482
            C C  GY+G  C + C P  Y +      S        P  G CV               
Sbjct: 1380 CDCPLGYSGLSCEA-CLPGFYRLR-----SQPGGRTPGPTLGTCV--------------- 1418

Query: 483  PGTWGFSCNASCQC-AHEAVCSPQTGAC-TCTPGWHGAHCQLPCPKGQFGEGCASRCDCD 540
                       CQC  H ++C P+T  C  C     G  C+  C  G +G       DC 
Sbjct: 1419 ----------PCQCNGHSSLCDPETSICQNCQHHTAGDFCER-CALGYYGIVKGLPNDCQ 1467

Query: 541  H-----------------SDGCDPVHGRCQ-CQAGWMGARCHLSCP-----EGLWGVNCS 577
                              ++G D    RC  C  G+ G  C    P      G  G +C 
Sbjct: 1468 QCACPLISSSNNFSPSCVAEGLDDY--RCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQ 1525

Query: 578  NTCTCKNGGT----CLPENGNCVCAPGFRGPSCQRSCQ--PGRYGKRCVPC 622
              C C   G+    C P  G C C PG  G  C   C+    R G  CV C
Sbjct: 1526 E-CECDPYGSLPVPCDPVTGFCTCRPGATGRKCD-GCKHWHAREGWECVFC 1574



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 61/260 (23%), Positives = 87/260 (33%), Gaps = 53/260 (20%)

Query: 106 AQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCG---NNSSCDPKSGV 162
           A+ C        ++C+C     GD C  +C PG       KP   G     + C+     
Sbjct: 293 ARACPLDPATNKSRCECEHNTCGDSC-DQCCPGFH----QKPWRAGTFLTKTECE----A 343

Query: 163 CSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQ 222
           C+C    +   C           +   R +  G       G C    + T     ++C  
Sbjct: 344 CNCHG--KAEECYYDENVARRNLSLNIRGKYIGG------GVCINCTQNT---AGINCET 392

Query: 223 GTSGFFCPSTHSCQNGGVFQTPQGSCSCPP-GWMGTIC---SLPCPEGFHGPNCSQECRC 278
            T GFF P   S      +  P   C C P G +  +C         G    +C   C+ 
Sbjct: 393 CTDGFFRPKGVSPN----YPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSC--HCKT 446

Query: 279 HNGGL-CDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLCE 337
             GG+ CD      RCA GYTG    + C     G    + C            G C+C+
Sbjct: 447 GFGGVSCD------RCARGYTGYPDCKACNCSGLGSKNEDPC-----------FGPCICK 489

Query: 338 HGFTGDRCTDRLCPDGFYGL 357
               G  C+   C  GF+ L
Sbjct: 490 ENVEGGDCS--RCKSGFFNL 507



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 62/287 (21%), Positives = 93/287 (32%), Gaps = 86/287 (29%)

Query: 462 IDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQ 521
           + G C+C  G  R   + P  P T      + C+C H   C      C   PG+H    Q
Sbjct: 283 VGGMCICY-GHAR---ACPLDPAT----NKSRCECEHNT-CGDSCDQCC--PGFH----Q 327

Query: 522 LPCPKGQF---GEGCASRC-----DCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWG 573
            P   G F    E  A  C     +C + +     +     +  ++G    ++C +   G
Sbjct: 328 KPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAG 387

Query: 574 VNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQP------GRYGKRCVPCKCANH 627
           +NC    TC +G             P    P+  R CQP      G   + CV  K   H
Sbjct: 388 INCE---TCTDG----------FFRPKGVSPNYPRPCQPCHCDPIGSLNEVCV--KDEKH 432

Query: 628 SFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWT 687
           +    + G+C+C  G+ G  C +                               C  G+T
Sbjct: 433 ARRGLAPGSCHCKTGFGGVSCDR-------------------------------CARGYT 461

Query: 688 GHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPC 734
           G+   + C     G+    PC            G C+C     G  C
Sbjct: 462 GYPDCKACNCSGLGSKNEDPC-----------FGPCICKENVEGGDC 497



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 9/108 (8%)

Query: 80  VKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRC-VAPNQCQCVPGWRGDDCSSECAPG 138
           V  ++ +  Q CH   +  G    +C ++  H R  +AP  C C  G+ G  C   CA G
Sbjct: 403 VSPNYPRPCQPCH--CDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSC-DRCARG 459

Query: 139 MWG-PQCDKPCSCG--NNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYY 183
             G P C K C+C    + + DP  G C C   ++  +C + C  G++
Sbjct: 460 YTGYPDC-KACNCSGLGSKNEDPCFGPCICKENVEGGDCSR-CKSGFF 505


>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
            sapiens]
          Length = 3122

 Score =  163 bits (412), Expect = 9e-40
 Identities = 143/488 (29%), Positives = 183/488 (37%), Gaps = 111/488 (22%)

Query: 120  CQCVPGWRGDDCSSECAPG-------MWGPQCDKPCSC-GNNSSCDPKSGVC-SCPSGLQ 170
            CQC PG+ G  C S C P        ++G  C+ PC C G+  SCD  +G C +C     
Sbjct: 724  CQCPPGYTGSSCES-CWPRHRRVNGTIFGGICE-PCQCFGHAESCDDVTGECLNCKDHTG 781

Query: 171  PPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCP 230
             P C   C PG+YG   +   +     C P       P+    P+C +  S G     C 
Sbjct: 782  GPYC-DKCLPGFYGEPTKGTSE----DCQPCACPLNIPSNNFSPTCHLDRSLG---LICD 833

Query: 231  STHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGP-----NCSQECRCHNG---- 281
                               CP G+ G  C   C EG+ G         Q C+C++     
Sbjct: 834  G------------------CPVGYTGPRCER-CAEGYFGQPSVPGGSCQPCQCNDNLDFS 874

Query: 282  --GLCDRFTGQCR-CAPGYTGDRCREECPVGRFGQDCAETCDCAP---------DARCFP 329
              G CD  +G C  C PG TG  C E C  G FG D  +  +C P            C  
Sbjct: 875  IPGSCDSLSGSCLICKPGTTGRYC-ELCADGYFG-DAVDAKNCQPCRCNAGGSFSEVCHS 932

Query: 330  ANGACLCEHGFTGDRCTDRLCPDGFYGLSCQ---APCTCDR--EHSLSCHPMNGECSCLP 384
              G C C     G RC    C  G +GL       PC C+     S  C   +G+C C P
Sbjct: 933  QTGQCECRANVQGQRCDK--CKAGTFGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQP 989

Query: 385  GWAGLHCNESCPQDTHG------PGCQEHCLCLH-GGVCQATSGLCQCAPGYTGPHCASL 437
            G  G    + C +  HG       GC   C C H G  C   +G C C P   G  C S 
Sbjct: 990  GVTG----KKCDRCAHGYFNFQEGGCTA-CECSHLGNNCDPKTGRCICPPNTIGEKC-SK 1043

Query: 438  CPPDTYGVNCSARCSCENAIACSPID-------GECVCKEGWQRGNCSVPCPPGTWGFSC 490
            C P+T+G + +  C   N      +D       G+C C   +    C+  C  G W +  
Sbjct: 1044 CAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCT-ECSRGHWNYPR 1102

Query: 491  NASCQC-------------AHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFG------E 531
               C C               +  CS QTG CTC     G HC   C  G+FG       
Sbjct: 1103 CNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCD-RCRPGKFGLDAKNPL 1161

Query: 532  GCASRCDC 539
            GC+S C C
Sbjct: 1162 GCSS-CYC 1168



 Score =  163 bits (412), Expect = 9e-40
 Identities = 143/487 (29%), Positives = 183/487 (37%), Gaps = 114/487 (23%)

Query: 291  CRCAPGYTGDRCREECPVGR------FGQDCAETCDCAPDAR-CFPANGACLCEHGFTGD 343
            C+C PGYTG  C    P  R      FG  C E C C   A  C    G CL     TG 
Sbjct: 724  CQCPPGYTGSSCESCWPRHRRVNGTIFGGIC-EPCQCFGHAESCDDVTGECLNCKDHTGG 782

Query: 344  RCTDRLCPDGFYGL-------SCQAPCTC-----DREHSLSCHPMNGECSCLPGWAGLHC 391
               D+  P GFYG         CQ PC C         S +CH        L    GL C
Sbjct: 783  PYCDKCLP-GFYGEPTKGTSEDCQ-PCACPLNIPSNNFSPTCH--------LDRSLGLIC 832

Query: 392  NESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARC 451
             + CP    GP C+                  +CA GY G        P   G +C   C
Sbjct: 833  -DGCPVGYTGPRCE------------------RCAEGYFGQ-------PSVPGGSCQP-C 865

Query: 452  SCENAI------ACSPIDGEC-VCKEGWQRGNCSVPCPPGTWGFSCNAS----CQC---- 496
             C + +      +C  + G C +CK G     C + C  G +G + +A     C+C    
Sbjct: 866  QCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL-CADGYFGDAVDAKNCQPCRCNAGG 924

Query: 497  AHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFG----EGCASRCDCDH----SDGCDPV 548
            +   VC  QTG C C     G  C   C  G FG     GC   C+C+     S  C+  
Sbjct: 925  SFSEVCHSQTGQCECRANVQGQRCD-KCKAGTFGLQSARGCVP-CNCNSFGSKSFDCEE- 981

Query: 549  HGRCQCQAGWMGARCHLSCPEGLWGVN---CSNTCTCKN-GGTCLPENGNCVCAPGFRGP 604
             G+C CQ G  G +C   C  G +      C+  C C + G  C P+ G C+C P   G 
Sbjct: 982  SGQCWCQPGVTGKKCD-RCAHGYFNFQEGGCT-ACECSHLGNNCDPKTGRCICPPNTIGE 1039

Query: 605  SCQRSCQPGRYGKR----CVPCKCANHSF----CHPSNGTCYCLAGWTGPDCSQPCPPGH 656
             C + C P  +G      C  C C+        C+ + G C C   ++G  C++ C  GH
Sbjct: 1040 KCSK-CAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTE-CSRGH 1097

Query: 657  WGENCAQTCQCHHGGT-------------CHPQDGSCICPLGWTGHHCLEGCPLGTFGAN 703
            W       C C   GT             C  Q G C C +   G HC + C  G FG +
Sbjct: 1098 WNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHC-DRCRPGKFGLD 1156

Query: 704  CSQPCQC 710
               P  C
Sbjct: 1157 AKNPLGC 1163



 Score =  147 bits (370), Expect = 7e-35
 Identities = 115/384 (29%), Positives = 158/384 (41%), Gaps = 71/384 (18%)

Query: 414  GVCQATSGLCQCAPGYTGPHCASLCPPDT------YGVNCSARCSC-ENAIACSPIDGEC 466
            G   A   +CQC PGYTG  C S  P         +G  C   C C  +A +C  + GEC
Sbjct: 715  GSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEP-CQCFGHAESCDDVTGEC 773

Query: 467  V-CKEGWQRGNCSVPCPPGTWGFSCNAS------CQCAHEAVCSPQTGACT--------- 510
            + CK+      C   C PG +G     +      C C      +  +  C          
Sbjct: 774  LNCKDHTGGPYCD-KCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLIC 832

Query: 511  --CTPGWHGAHCQLPCPKGQFGE-----GCASRCDCDHS------DGCDPVHGRCQ-CQA 556
              C  G+ G  C+  C +G FG+     G    C C+ +        CD + G C  C+ 
Sbjct: 833  DGCPVGYTGPRCER-CAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKP 891

Query: 557  GWMGARCHLSCPEGLWG-----VNCSNTCTCKNGGT----CLPENGNCVCAPGFRGPSCQ 607
            G  G  C L C +G +G      NC   C C  GG+    C  + G C C    +G  C 
Sbjct: 892  GTTGRYCEL-CADGYFGDAVDAKNCQ-PCRCNAGGSFSEVCHSQTGQCECRANVQGQRCD 949

Query: 608  RSCQPGRYG----KRCVPCKC---ANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWG-- 658
            + C+ G +G    + CVPC C    + SF    +G C+C  G TG  C + C  G++   
Sbjct: 950  K-CKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDR-CAHGYFNFQ 1007

Query: 659  ENCAQTCQCHH-GGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCS---QPCQCGP-- 712
            E     C+C H G  C P+ G CICP    G  C + C   T+G + +   + C C    
Sbjct: 1008 EGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSK-CAPNTWGHSITTGCKACNCSTVG 1066

Query: 713  --GEKCHPETGACVCPPGHSGAPC 734
                +C+  TG C C P  SGA C
Sbjct: 1067 SLDFQCNVNTGQCNCHPKFSGAKC 1090



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 80/286 (27%), Positives = 104/286 (36%), Gaps = 68/286 (23%)

Query: 119  QCQCVPGWRGDDCSSECAPGMWGPQCDK---PCSC---GNNSSCDPKSGVCSCPSGLQPP 172
            QC+C    +G  C  +C  G +G Q  +   PC+C   G+ S    +SG C C  G+   
Sbjct: 936  QCECRANVQGQRCD-KCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGK 994

Query: 173  NCLQPCTPGYY----GPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFF 228
             C   C  GY+    G      C   G  CDP+TG C CP    G  C   C+  T G  
Sbjct: 995  KC-DRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCS-KCAPNTWG-- 1050

Query: 229  CPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFT 288
                HS   G        +C+C      T+ SL                      C+  T
Sbjct: 1051 ----HSITTG------CKACNC-----STVGSLDFQ-------------------CNVNT 1076

Query: 289  GQCRCAPGYTGDRCREECPVGRFGQDCAETCDC-------------APDARCFPANGACL 335
            GQC C P ++G +C  EC  G +       CDC                  C    G C 
Sbjct: 1077 GQCNCHPKFSGAKC-TECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCT 1135

Query: 336  CEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECS 381
            C+    G  C DR C  G +GL  + P  C    S  C     +CS
Sbjct: 1136 CKVNVEGIHC-DR-CRPGKFGLDAKNPLGCS---SCYCFGTTTQCS 1176



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 64/207 (30%), Positives = 81/207 (39%), Gaps = 47/207 (22%)

Query: 571 LWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGR-------YGKRCVPCK 623
           L  VN  +  +    G+       C C PG+ G SC+ SC P         +G  C PC+
Sbjct: 700 LSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCE-SCWPRHRRVNGTIFGGICEPCQ 758

Query: 624 CANHS-FCHPSNGTCYCLAGWTGPDCSQPCPPGHWGE------NCAQTCQC-------HH 669
           C  H+  C    G C      TG      C PG +GE         Q C C       + 
Sbjct: 759 CFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNF 818

Query: 670 GGTCHPQ-------DGSCICPLGWTGHHCLEGCPLGTFG-----ANCSQPCQCG------ 711
             TCH         DG   CP+G+TG  C E C  G FG         QPCQC       
Sbjct: 819 SPTCHLDRSLGLICDG---CPVGYTGPRC-ERCAEGYFGQPSVPGGSCQPCQCNDNLDFS 874

Query: 712 -PGEKCHPETGAC-VCPPGHSGAPCRI 736
            PG  C   +G+C +C PG +G  C +
Sbjct: 875 IPG-SCDSLSGSCLICKPGTTGRYCEL 900



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 55/180 (30%), Positives = 70/180 (38%), Gaps = 42/180 (23%)

Query: 595  CVCAPGFRGPSCQRSCQPGRYGKR--------------CVPCKCANHS-FCHPSNGTCYC 639
            C C  G+ G SC+ +C PG Y  R              CVPC+C  HS  C P    C  
Sbjct: 1380 CDCPLGYSGLSCE-ACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438

Query: 640  LAGWTGPDCSQPCPPGHWG-----ENCAQTCQCHHGGTCHPQDGSCI-----------CP 683
                T  D  + C  G++G      N  Q C C    + +    SC+           CP
Sbjct: 1439 CQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACP 1498

Query: 684  LGWTGHHCLEGCP-----LGTFGANCSQPCQCGPGEK----CHPETGACVCPPGHSGAPC 734
             G+ G +C    P      G  G +C Q C+C P       C P TG C C PG +G  C
Sbjct: 1499 RGYEGQYCERCAPGYTGSPGNPGGSC-QECECDPYGSLPVPCDPVTGFCTCRPGATGRKC 1557



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 76/285 (26%), Positives = 111/285 (38%), Gaps = 67/285 (23%)

Query: 53   EPCERPWEGPHTCPQPTVVYRTVYRQ----VVKTDHRQRLQCCHGFY--ESRGFCVPLCA 106
            E  E+ W+     P+   V+RTV R+    ++   H   ++  +G +  +SR   + +  
Sbjct: 1305 EMTEKEWKYYGDDPR---VHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEV 1361

Query: 107  QECVHGRCVAP-----NQCQCVPGWRGDDCSSECAPGMW-----------GPQCDK--PC 148
             E   G  + P      +C C  G+ G  C + C PG +           GP      PC
Sbjct: 1362 AEQGRGTTMTPPADLIEKCDCPLGYSGLSCEA-CLPGFYRLRSQPGGRTPGPTLGTCVPC 1420

Query: 149  SC-GNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFC 207
             C G++S CDP++ +C         +  + C  GYYG          G P D Q   C C
Sbjct: 1421 QCNGHSSLCDPETSICQNCQHHTAGDFCERCALGYYGIV-------KGLPNDCQQ--CAC 1471

Query: 208  PAERTGPSCDVSC-SQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCP-- 264
            P   +  +   SC ++G   + C +                  CP G+ G  C    P  
Sbjct: 1472 PLISSSNNFSPSCVAEGLDDYRCTA------------------CPRGYEGQYCERCAPGY 1513

Query: 265  ---EGFHGPNCSQECRCHNGGL----CDRFTGQCRCAPGYTGDRC 302
                G  G +C QEC C   G     CD  TG C C PG TG +C
Sbjct: 1514 TGSPGNPGGSC-QECECDPYGSLPVPCDPVTGFCTCRPGATGRKC 1557



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 73/239 (30%), Positives = 87/239 (36%), Gaps = 69/239 (28%)

Query: 163  CSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPS--CDVSC 220
            C CP G    +C + C PG+Y    + R Q  G    P  G C  P +  G S  CD   
Sbjct: 1380 CDCPLGYSGLSC-EACLPGFY----RLRSQPGGRTPGPTLGTCV-PCQCNGHSSLCD--- 1430

Query: 221  SQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHG-----PNCSQE 275
                     P T  CQN            C     G  C   C  G++G     PN  Q+
Sbjct: 1431 ---------PETSICQN------------CQHHTAGDFCER-CALGYYGIVKGLPNDCQQ 1468

Query: 276  CRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACL 335
            C C      + F+  C  A G    RC   CP G  GQ C     CAP            
Sbjct: 1469 CACPLISSSNNFSPSC-VAEGLDDYRCTA-CPRGYEGQYCER---CAP------------ 1511

Query: 336  CEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLS--CHPMNGECSCLPGWAGLHCN 392
               G+TG          G  G SCQ  C CD   SL   C P+ G C+C PG  G  C+
Sbjct: 1512 ---GYTGS--------PGNPGGSCQE-CECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 65/252 (25%), Positives = 81/252 (32%), Gaps = 77/252 (30%)

Query: 350  CPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGP--GCQEH 407
            CP G+ GLSC+A                    CLPG+  L         T GP  G    
Sbjct: 1382 CPLGYSGLSCEA--------------------CLPGFYRLRSQPG--GRTPGPTLGTCVP 1419

Query: 408  CLCL-HGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGV-----NCSARCSCENAIACSP 461
            C C  H  +C   + +CQ    +T       C    YG+     N   +C+C    + + 
Sbjct: 1420 CQCNGHSSLCDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNN 1479

Query: 462  IDGECV-----------CKEGWQRGNCSVPCP-----PGTWGFSCNASCQC----AHEAV 501
                CV           C  G++   C    P     PG  G SC   C+C    +    
Sbjct: 1480 FSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQ-ECECDPYGSLPVP 1538

Query: 502  CSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGA 561
            C P TG CTC PG  G  C                      DGC   H R     GW   
Sbjct: 1539 CDPVTGFCTCRPGATGRKC----------------------DGCKHWHAR----EGWECV 1572

Query: 562  RCHLSCPEGLWG 573
             C   C   L G
Sbjct: 1573 FCGDECTGLLLG 1584



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 55/170 (32%), Positives = 66/170 (38%), Gaps = 47/170 (27%)

Query: 90   CCHGFYESR------------GFCVPLCAQECVHGRCVAPNQ--CQ-CVPGWRGDDCSSE 134
            C  GFY  R            G CVP   Q   H     P    CQ C     GD C   
Sbjct: 1394 CLPGFYRLRSQPGGRTPGPTLGTCVP--CQCNGHSSLCDPETSICQNCQHHTAGDFCE-R 1450

Query: 135  CAPGMWG-----PQCDKPCSCGNNSSCDPKSGVC-----------SCPSGLQPPNCLQPC 178
            CA G +G     P   + C+C   SS +  S  C           +CP G +   C + C
Sbjct: 1451 CALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYEGQYC-ERC 1509

Query: 179  TPGYYGP------ACQFRCQC--HGA---PCDPQTGACFCPAERTGPSCD 217
             PGY G       +CQ  C+C  +G+   PCDP TG C C    TG  CD
Sbjct: 1510 APGYTGSPGNPGGSCQ-ECECDPYGSLPVPCDPVTGFCTCRPGATGRKCD 1558



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 70/270 (25%), Positives = 89/270 (32%), Gaps = 98/270 (36%)

Query: 290 QCRCAPGYTGDRCREECP--------VGRF--GQDCAETCDCAPDAR-CFP--------- 329
           +C C     GD C + CP         G F    +C E C+C   A  C+          
Sbjct: 306 RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTEC-EACNCHGKAEECYYDENVARRNL 364

Query: 330 ---------ANGACL-CEHGFTGDRCTDRLCPDGFY---GLS------CQAPCTCDREHS 370
                      G C+ C     G  C    C DGF+   G+S      CQ PC CD   S
Sbjct: 365 SLNIRGKYIGGGVCINCTQNTAGINC--ETCTDGFFRPKGVSPNYPRPCQ-PCHCDPIGS 421

Query: 371 LS--C-----HPMNG----ECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQAT 419
           L+  C     H   G     C C  G+ G+ C+                           
Sbjct: 422 LNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCD--------------------------- 454

Query: 420 SGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSV 479
               +CA GYTG        PD    NCS   S        P  G C+CKE  + G+CS 
Sbjct: 455 ----RCARGYTG-------YPDCKACNCSGLGSKNE----DPCFGPCICKENVEGGDCS- 498

Query: 480 PCPPGTWGFSCNASCQCAHEAVCSPQTGAC 509
            C  G +    +    C  E  CS  +  C
Sbjct: 499 RCKSGFFNLQEDNWKGC-DECFCSGVSNRC 527



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 60/231 (25%), Positives = 74/231 (32%), Gaps = 67/231 (29%)

Query: 423  CQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCP 482
            C C  GY+G  C + C P  Y +      S        P  G CV               
Sbjct: 1380 CDCPLGYSGLSCEA-CLPGFYRLR-----SQPGGRTPGPTLGTCV--------------- 1418

Query: 483  PGTWGFSCNASCQC-AHEAVCSPQTGAC-TCTPGWHGAHCQLPCPKGQFGEGCASRCDCD 540
                       CQC  H ++C P+T  C  C     G  C+  C  G +G       DC 
Sbjct: 1419 ----------PCQCNGHSSLCDPETSICQNCQHHTAGDFCER-CALGYYGIVKGLPNDCQ 1467

Query: 541  H-----------------SDGCDPVHGRCQ-CQAGWMGARCHLSCP-----EGLWGVNCS 577
                              ++G D    RC  C  G+ G  C    P      G  G +C 
Sbjct: 1468 QCACPLISSSNNFSPSCVAEGLDDY--RCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQ 1525

Query: 578  NTCTCKNGGT----CLPENGNCVCAPGFRGPSCQRSCQ--PGRYGKRCVPC 622
              C C   G+    C P  G C C PG  G  C   C+    R G  CV C
Sbjct: 1526 E-CECDPYGSLPVPCDPVTGFCTCRPGATGRKCD-GCKHWHAREGWECVFC 1574



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 61/260 (23%), Positives = 87/260 (33%), Gaps = 53/260 (20%)

Query: 106 AQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCG---NNSSCDPKSGV 162
           A+ C        ++C+C     GD C  +C PG       KP   G     + C+     
Sbjct: 293 ARACPLDPATNKSRCECEHNTCGDSC-DQCCPGFH----QKPWRAGTFLTKTECE----A 343

Query: 163 CSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQ 222
           C+C    +   C           +   R +  G       G C    + T     ++C  
Sbjct: 344 CNCHG--KAEECYYDENVARRNLSLNIRGKYIGG------GVCINCTQNT---AGINCET 392

Query: 223 GTSGFFCPSTHSCQNGGVFQTPQGSCSCPP-GWMGTIC---SLPCPEGFHGPNCSQECRC 278
            T GFF P   S      +  P   C C P G +  +C         G    +C   C+ 
Sbjct: 393 CTDGFFRPKGVSPN----YPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSC--HCKT 446

Query: 279 HNGGL-CDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLCE 337
             GG+ CD      RCA GYTG    + C     G    + C            G C+C+
Sbjct: 447 GFGGVSCD------RCARGYTGYPDCKACNCSGLGSKNEDPC-----------FGPCICK 489

Query: 338 HGFTGDRCTDRLCPDGFYGL 357
               G  C+   C  GF+ L
Sbjct: 490 ENVEGGDCS--RCKSGFFNL 507



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 62/287 (21%), Positives = 93/287 (32%), Gaps = 86/287 (29%)

Query: 462 IDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQ 521
           + G C+C  G  R   + P  P T      + C+C H   C      C   PG+H    Q
Sbjct: 283 VGGMCICY-GHAR---ACPLDPAT----NKSRCECEHNT-CGDSCDQCC--PGFH----Q 327

Query: 522 LPCPKGQF---GEGCASRC-----DCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWG 573
            P   G F    E  A  C     +C + +     +     +  ++G    ++C +   G
Sbjct: 328 KPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAG 387

Query: 574 VNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQP------GRYGKRCVPCKCANH 627
           +NC    TC +G             P    P+  R CQP      G   + CV  K   H
Sbjct: 388 INCE---TCTDG----------FFRPKGVSPNYPRPCQPCHCDPIGSLNEVCV--KDEKH 432

Query: 628 SFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWT 687
           +    + G+C+C  G+ G  C +                               C  G+T
Sbjct: 433 ARRGLAPGSCHCKTGFGGVSCDR-------------------------------CARGYT 461

Query: 688 GHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPC 734
           G+   + C     G+    PC            G C+C     G  C
Sbjct: 462 GYPDCKACNCSGLGSKNEDPC-----------FGPCICKENVEGGDC 497



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 9/108 (8%)

Query: 80  VKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRC-VAPNQCQCVPGWRGDDCSSECAPG 138
           V  ++ +  Q CH   +  G    +C ++  H R  +AP  C C  G+ G  C   CA G
Sbjct: 403 VSPNYPRPCQPCH--CDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSC-DRCARG 459

Query: 139 MWG-PQCDKPCSCG--NNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYY 183
             G P C K C+C    + + DP  G C C   ++  +C + C  G++
Sbjct: 460 YTGYPDC-KACNCSGLGSKNEDPCFGPCICKENVEGGDCSR-CKSGFF 505


>gi|119703755 laminin, beta 2 precursor [Homo sapiens]
          Length = 1798

 Score =  162 bits (409), Expect = 2e-39
 Identities = 142/449 (31%), Positives = 177/449 (39%), Gaps = 88/449 (19%)

Query: 319  CDCAPD----ARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLS---CQAPCTCDREHSL 371
            C C P     + C P  G CLC+ G  G RC   LC  G+YG     CQA C C  E +L
Sbjct: 783  CQCNPQGSLSSECNPHGGQCLCKPGVVGRRCD--LCAPGYYGFGPTGCQA-CQCSHEGAL 839

Query: 372  S--CHPMNGECSCLPGWAGLHCNESCPQDTHG-PGCQEHCLCL-HGGVCQATSGLCQCAP 427
            S  C   +G+C C  G  GL C + C +   G P C+  C+C  H   C   +G C    
Sbjct: 840  SSLCEKTSGQCLCRTGAFGLRC-DRCQRGQWGFPSCRP-CVCNGHADECNTHTGACLGCR 897

Query: 428  GYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWG 487
             +TG                     CE  IA     G+     G Q   C  PCP G  G
Sbjct: 898  DHTGGE------------------HCERCIA--GFHGDPRLPYGGQCRPC--PCPEGP-G 934

Query: 488  FSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGE-----GCASRCDCDHS 542
               + +  C H+   S Q   C C  G+ G  C+  C  G FG+     G    C+C  +
Sbjct: 935  SQRHFATSC-HQDEYSQQI-VCHCRAGYTGLRCE-ACAPGHFGDPSRPGGRCQLCECSGN 991

Query: 543  ------DGCDPVHGRC-QCQAGWMGARCHLSCPEGLWGV---NCSNTCTCKNGGT----- 587
                  D CDP  G+C +C     G  C   C  G  G       + CTC   GT     
Sbjct: 992  IDPMDPDACDPHTGQCLRCLHHTEGPHC-AHCKPGFHGQAARQSCHRCTCNLLGTNPQQC 1050

Query: 588  -------CLPENGNCVCAPGFRGPSCQRSCQPGRY----GKRCVPCKC----ANHSFCHP 632
                   C P +G C C P  +GPSC R C P  +    G  C PC C    A    C+ 
Sbjct: 1051 PSPDQCHCDPSSGQCPCLPNVQGPSCDR-CAPNFWNLTSGHGCQPCACHPSRARGPTCNE 1109

Query: 633  SNGTCYCLAGWTGPDCSQPCPPGHWGENCAQ--TCQCHHGG----TCHPQDGSCICPLGW 686
              G C+C AG+ G  CS+ C   HWG+   Q   C C   G     CH   G C C  G 
Sbjct: 1110 FTGQCHCRAGFGGRTCSE-CQELHWGDPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPGV 1168

Query: 687  TGHHCLEGCPLGTFGA-NCSQPCQCGPGE 714
            +G  C + C  G  G      PC    G+
Sbjct: 1169 SGVRC-DQCARGFSGIFPACHPCHACFGD 1196



 Score =  155 bits (393), Expect = 1e-37
 Identities = 124/389 (31%), Positives = 152/389 (39%), Gaps = 80/389 (20%)

Query: 416  CQATSGLCQCAPGYTGPHCASLCPPDTYG---VNCSA-RCSCENAIA--CSPIDGECVCK 469
            C    G C C PG  G  C  LC P  YG     C A +CS E A++  C    G+C+C+
Sbjct: 795  CNPHGGQCLCKPGVVGRRC-DLCAPGYYGFGPTGCQACQCSHEGALSSLCEKTSGQCLCR 853

Query: 470  EGWQRGNCSVPCPPGTWGFSCNASCQC-AHEAVCSPQTGACT-------------CTPGW 515
             G     C   C  G WGF     C C  H   C+  TGAC              C  G+
Sbjct: 854  TGAFGLRCD-RCQRGQWGFPSCRPCVCNGHADECNTHTGACLGCRDHTGGEHCERCIAGF 912

Query: 516  HG-------AHCQ-LPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSC 567
            HG         C+  PCP+G  G        C   +    +   C C+AG+ G RC  +C
Sbjct: 913  HGDPRLPYGGQCRPCPCPEGP-GSQRHFATSCHQDEYSQQIV--CHCRAGYTGLRCE-AC 968

Query: 568  PEGLWG-----------VNCSNTCTCKNGGTCLPENGNCV-CAPGFRGPSCQRSCQPGRY 615
              G +G             CS      +   C P  G C+ C     GP C   C+PG +
Sbjct: 969  APGHFGDPSRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGPHCAH-CKPGFH 1027

Query: 616  GK-------RCV-------PCKCANHSFCH--PSNGTCYCLAGWTGPDCSQPCPPGHW-- 657
            G+       RC        P +C +   CH  PS+G C CL    GP C + C P  W  
Sbjct: 1028 GQAARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDR-CAPNFWNL 1086

Query: 658  --GENCAQTCQCH----HGGTCHPQDGSCICPLGWTGHHCLEGCPL--GTFGANCSQPCQ 709
              G  C Q C CH     G TC+   G C C  G+ G  C E   L  G  G  C   C 
Sbjct: 1087 TSGHGC-QPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCSECQELHWGDPGLQC-HACD 1144

Query: 710  CGPG----EKCHPETGACVCPPGHSGAPC 734
            C        +CH  TG C C PG SG  C
Sbjct: 1145 CDSRGIDTPQCHRFTGHCSCRPGVSGVRC 1173



 Score =  148 bits (373), Expect = 3e-35
 Identities = 130/428 (30%), Positives = 167/428 (39%), Gaps = 88/428 (20%)

Query: 246  GSCSCPPGWMGTICSLPCPEGFH--GPNCSQECRCHNGG----LCDRFTGQCRCAPGYTG 299
            G C C PG +G  C L C  G++  GP   Q C+C + G    LC++ +GQC C  G  G
Sbjct: 800  GQCLCKPGVVGRRCDL-CAPGYYGFGPTGCQACQCSHEGALSSLCEKTSGQCLCRTGAFG 858

Query: 300  DRCREECPVGRFGQDCAETCDCAPDA-RCFPANGACL-CEHGFTGDRCTDRLCPDGFYGL 357
             RC + C  G++G      C C   A  C    GACL C     G+ C    C  GF+G 
Sbjct: 859  LRC-DRCQRGQWGFPSCRPCVCNGHADECNTHTGACLGCRDHTGGEHC--ERCIAGFHG- 914

Query: 358  SCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQ 417
                      +  L   P  G+C   P          CP+   GPG Q H          
Sbjct: 915  ----------DPRL---PYGGQCRPCP----------CPE---GPGSQRHFATSCHQDEY 948

Query: 418  ATSGLCQCAPGYTGPHCASLCP-----PDTYGVNCSARCSCENAI------ACSPIDGEC 466
            +   +C C  GYTG  C +  P     P   G  C   C C   I      AC P  G+C
Sbjct: 949  SQQIVCHCRAGYTGLRCEACAPGHFGDPSRPGGRCQL-CECSGNIDPMDPDACDPHTGQC 1007

Query: 467  V-CKEGWQRGNCSVPCPPGTWGFSCNASC-------------QC--AHEAVCSPQTGACT 510
            + C    +  +C+  C PG  G +   SC             QC    +  C P +G C 
Sbjct: 1008 LRCLHHTEGPHCA-HCKPGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCP 1066

Query: 511  CTPGWHGAHCQLPCPKG---QFGEGCASRCDCDHSDG----CDPVHGRCQCQAGWMGARC 563
            C P   G  C    P       G GC   C C  S      C+   G+C C+AG+ G  C
Sbjct: 1067 CLPNVQGPSCDRCAPNFWNLTSGHGC-QPCACHPSRARGPTCNEFTGQCHCRAGFGGRTC 1125

Query: 564  HLSCPEGLW---GVNCSNTCTCKNGGTCLPE----NGNCVCAPGFRGPSCQRSCQPGRYG 616
               C E  W   G+ C + C C + G   P+     G+C C PG  G  C + C  G  G
Sbjct: 1126 S-ECQELHWGDPGLQC-HACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQ-CARGFSG 1182

Query: 617  --KRCVPC 622
                C PC
Sbjct: 1183 IFPACHPC 1190



 Score =  140 bits (353), Expect = 6e-33
 Identities = 132/431 (30%), Positives = 166/431 (38%), Gaps = 91/431 (21%)

Query: 119  QCQCVPGWRGDDCSSECAPGMWG--PQCDKPCSCGN----NSSCDPKSGVCSCPSGLQPP 172
            QC C PG  G  C   CAPG +G  P   + C C +    +S C+  SG C C +G    
Sbjct: 801  QCLCKPGVVGRRCDL-CAPGYYGFGPTGCQACQCSHEGALSSLCEKTSGQCLCRTGAFGL 859

Query: 173  NCLQPCTPGYYG-PACQFRCQC--HGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFC 229
             C   C  G +G P+C+  C C  H   C+  TGAC    + TG      C +  +GF  
Sbjct: 860  RC-DRCQRGQWGFPSCR-PCVCNGHADECNTHTGACLGCRDHTGGE---HCERCIAGFH- 913

Query: 230  PSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTG 289
                     G  + P G   C P         PCPEG  G        CH     D ++ 
Sbjct: 914  ---------GDPRLPYGG-QCRP--------CPCPEG-PGSQRHFATSCHQ----DEYSQ 950

Query: 290  Q--CRCAPGYTGDRCREECPVGRFGQDC-----AETCDCA-------PDARCFPANGACL 335
            Q  C C  GYTG RC E C  G FG         + C+C+       PDA C P  G CL
Sbjct: 951  QIVCHCRAGYTGLRC-EACAPGHFGDPSRPGGRCQLCECSGNIDPMDPDA-CDPHTGQCL 1008

Query: 336  -CEHGFTGDRCTDRLCPDGFYGLSCQAPC-------------TCDREHSLSCHPMNGECS 381
             C H   G  C    C  GF+G + +  C              C       C P +G+C 
Sbjct: 1009 RCLHHTEGPHCAH--CKPGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCP 1066

Query: 382  CLPGWAGLHCNESCPQD---THGPGCQEHCLC----LHGGVCQATSGLCQCAPGYTGPHC 434
            CLP   G  C+   P     T G GCQ  C C      G  C   +G C C  G+ G  C
Sbjct: 1067 CLPNVQGPSCDRCAPNFWNLTSGHGCQP-CACHPSRARGPTCNEFTGQCHCRAGFGGRTC 1125

Query: 435  ASLCPPDTY---GVNCSARCSCE----NAIACSPIDGECVCKEGWQRGNCSVPCPPGTWG 487
             S C    +   G+ C A C C+    +   C    G C C+ G     C   C  G  G
Sbjct: 1126 -SECQELHWGDPGLQCHA-CDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCD-QCARGFSG 1182

Query: 488  F--SCNASCQC 496
               +C+    C
Sbjct: 1183 IFPACHPCHAC 1193



 Score =  120 bits (301), Expect = 7e-27
 Identities = 90/298 (30%), Positives = 114/298 (38%), Gaps = 52/298 (17%)

Query: 490  CNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFG---EGCASRCDCDH----S 542
            C  + Q +  + C+P  G C C PG  G  C L C  G +G    GC + C C H    S
Sbjct: 783  CQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDL-CAPGYYGFGPTGCQA-CQCSHEGALS 840

Query: 543  DGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCK-NGGTCLPENGNCV-CAPG 600
              C+   G+C C+ G  G RC   C  G WG      C C  +   C    G C+ C   
Sbjct: 841  SLCEKTSGQCLCRTGAFGLRCD-RCQRGQWGFPSCRPCVCNGHADECNTHTGACLGCRDH 899

Query: 601  FRGPSCQRSCQPG-------RYGKRCVPCKCANH--------SFCHPSNGT----CYCLA 641
              G  C+R C  G        YG +C PC C           + CH    +    C+C A
Sbjct: 900  TGGEHCER-CIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRA 958

Query: 642  GWTGPDCSQPCPPGHWGENC-----AQTCQCHHG------GTCHPQDGSCICPLGWT-GH 689
            G+TG  C + C PGH+G+        Q C+C           C P  G C+  L  T G 
Sbjct: 959  GYTGLRC-EACAPGHFGDPSRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGP 1017

Query: 690  HCLEGCPLGTFGANCSQPCQ------CGPGEKCHPETGACVCPPGHSGAPCRIGIQEP 741
            HC   C  G  G    Q C        G   +  P    C C P     PC   +Q P
Sbjct: 1018 HCAH-CKPGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGP 1074



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 85/255 (33%), Positives = 105/255 (41%), Gaps = 60/255 (23%)

Query: 120  CQCVPGWRGDDCSSECAPGMWGPQCDKP------CSCGNN------SSCDPKSGVC-SCP 166
            C C  G+ G  C + CAPG +G    +P      C C  N       +CDP +G C  C 
Sbjct: 954  CHCRAGYTGLRCEA-CAPGHFGDP-SRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCL 1011

Query: 167  SGLQPPNCLQPCTPGYYGPACQFRC-------------------QCHGAPCDPQTGACFC 207
               + P+C   C PG++G A +  C                   QCH   CDP +G C C
Sbjct: 1012 HHTEGPHCAH-CKPGFHGQAARQSCHRCTCNLLGTNPQQCPSPDQCH---CDPSSGQCPC 1067

Query: 208  PAERTGPSCDVSCSQG----TSGFFCP--STH-SCQNGGVFQTPQGSCSCPPGWMGTICS 260
                 GPSCD  C+      TSG  C   + H S   G       G C C  G+ G  CS
Sbjct: 1068 LPNVQGPSCD-RCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCS 1126

Query: 261  LPCPE---GFHGPNCSQECRCHNGGL----CDRFTGQCRCAPGYTGDRCREECPVGRFGQ 313
              C E   G  G  C   C C + G+    C RFTG C C PG +G RC ++C  G  G 
Sbjct: 1127 -ECQELHWGDPGLQC-HACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRC-DQCARGFSGI 1183

Query: 314  DCAETCDCAPDARCF 328
              A    C P   CF
Sbjct: 1184 FPA----CHPCHACF 1194



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 72/255 (28%), Positives = 92/255 (36%), Gaps = 66/255 (25%)

Query: 462 IDGECVCKEGWQRGNCS--------VPCPPGTWGFS--CNASCQC-AHEAVC-------- 502
           + G C+CK   +  NC         +P  P   G S  C   C+C  H   C        
Sbjct: 306 VHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACR-KCECHGHTHSCHFDMAVYL 364

Query: 503 ---SPQTGACT-CTPGWHGAHCQLPCP-------KGQFGEGCASRCDCD---HSDG--CD 546
              +   G C  C     G HC+L  P       K          CDCD     DG  CD
Sbjct: 365 ASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCD 424

Query: 547 P--------VHGRCQCQAGWMGARCHLSCPEGLWGVNCSN-----TCTCKNGGT------ 587
                    V G+C+C+   +G RC   C +G +G++ S+      C C   GT      
Sbjct: 425 SHDDPALGLVSGQCRCKEHVVGTRCQ-QCRDGFFGLSISDRLGCRRCQCNARGTVPGSTP 483

Query: 588 CLPENGNCVCAPGFRGPSCQRSCQPGRYGKR-----CVPCKC----ANHSFCHPSNGTCY 638
           C P +G+C C     G  C R C PG +G       C PC C    A    C    G C+
Sbjct: 484 CDPNSGSCYCKRLVTGRGCDR-CLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQCH 542

Query: 639 CLAGWTGPDCSQPCP 653
           C     G  C Q  P
Sbjct: 543 CRQHMVGRRCEQVQP 557



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 77/281 (27%), Positives = 100/281 (35%), Gaps = 50/281 (17%)

Query: 316 AETCDCAPDARCFP---ANGACLCEHGFTG---DRCTD-------RLCPDGFYGLSCQAP 362
           A  C  AP A        +GAC+C+H   G   ++C D       R   DG +  +C+  
Sbjct: 289 ASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDG-HSHACRK- 346

Query: 363 CTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGL 422
           C C   H+ SCH            +G  C + C  +T G  C+   LC        T  L
Sbjct: 347 CEC-HGHTHSCHFDMAVYLASGNVSGGVC-DGCQHNTAGRHCE---LCRPFFYRDPTKDL 401

Query: 423 CQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCP 482
                    P     C  D  G     RC   +  A   + G+C CKE      C   C 
Sbjct: 402 -------RDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQ-QCR 453

Query: 483 PGTWGFS-----------CNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFG- 530
            G +G S           CNA         C P +G+C C     G  C   C  G +G 
Sbjct: 454 DGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCD-RCLPGHWGL 512

Query: 531 ----EGCASRCDCDHSDG----CDPVHGRCQCQAGWMGARC 563
                GC   CDCD        CD   G+C C+   +G RC
Sbjct: 513 SHDLLGCRP-CDCDVGGALDPQCDEGTGQCHCRQHMVGRRC 552



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 47/150 (31%), Positives = 65/150 (43%), Gaps = 35/150 (23%)

Query: 113  RCVAPNQCQ---------CVPGWRGDDCSSECAPGMW----GPQCDKPCSC----GNNSS 155
            +C +P+QC          C+P  +G  C   CAP  W    G  C +PC+C        +
Sbjct: 1049 QCPSPDQCHCDPSSGQCPCLPNVQGPSC-DRCAPNFWNLTSGHGC-QPCACHPSRARGPT 1106

Query: 156  CDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCD------PQ----TGAC 205
            C+  +G C C +G     C + C   ++G       QCH   CD      PQ    TG C
Sbjct: 1107 CNEFTGQCHCRAGFGGRTCSE-CQELHWGDP---GLQCHACDCDSRGIDTPQCHRFTGHC 1162

Query: 206  FCPAERTGPSCDVSCSQGTSGFFCPSTHSC 235
             C    +G  CD  C++G SG F P+ H C
Sbjct: 1163 SCRPGVSGVRCD-QCARGFSGIF-PACHPC 1190



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 51/193 (26%), Positives = 66/193 (34%), Gaps = 61/193 (31%)

Query: 132 SSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPA----- 186
           S +C P   G Q    C   ++ +    SG C C   +    C Q C  G++G +     
Sbjct: 409 SCDCDP--MGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRC-QQCRDGFFGLSISDRL 465

Query: 187 -CQFRCQCHG-------APCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNG 238
            C+ RCQC+         PCDP +G+C+C    TG  CD                     
Sbjct: 466 GCR-RCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCD--------------------- 503

Query: 239 GVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGL----CDRFTGQCRCA 294
                      C PG  G           H     + C C  GG     CD  TGQC C 
Sbjct: 504 ----------RCLPGHWGLS---------HDLLGCRPCDCDVGGALDPQCDEGTGQCHCR 544

Query: 295 PGYTGDRCREECP 307
               G RC +  P
Sbjct: 545 QHMVGRRCEQVQP 557



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 74/300 (24%), Positives = 96/300 (32%), Gaps = 78/300 (26%)

Query: 191 CQCHGAPCDPQTGACFCPAERTGPSCDVS-CSQGTSGFFCPSTHSCQNGGVFQTPQGSCS 249
           C  H + C P  GA   PA   G       C   T G  C     CQ+            
Sbjct: 285 CYGHASECAPAPGA---PAHAEGMVHGACICKHNTRGLNC---EQCQD------------ 326

Query: 250 CPPGWMGTICSLPCPEGFHGPNCSQECRCH-------------------NGGLCD----R 286
               +   +   P  +G H   C ++C CH                   +GG+CD     
Sbjct: 327 ----FYRDLPWRPAEDG-HSHAC-RKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHN 380

Query: 287 FTGQ-CR-CAPGYTGDRCRE--------ECPVGRFGQDCAETCDCAPDARCFPANGACLC 336
             G+ C  C P +  D  ++         C     G      CD   D      +G C C
Sbjct: 381 TAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRC 440

Query: 337 EHGFTGDRCTDRLCPDGFYGLS---------CQAPCTCDREHSLSCHPMNGECSCLPGWA 387
           +    G RC    C DGF+GLS         CQ         S  C P +G C C     
Sbjct: 441 KEHVVGTRCQQ--CRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVT 498

Query: 388 GLHCNESCPQD---THG-PGCQEHCLCLHGGV----CQATSGLCQCAPGYTGPHCASLCP 439
           G  C+   P     +H   GC+  C C  GG     C   +G C C     G  C  + P
Sbjct: 499 GRGCDRCLPGHWGLSHDLLGCRP-CDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQP 557



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 74/295 (25%), Positives = 100/295 (33%), Gaps = 77/295 (26%)

Query: 493 SCQC-AHEAVCSPQTGA-----------CTCTPGWHGAHCQ--------LPCPKGQFGEG 532
           +C C  H + C+P  GA           C C     G +C+        LP    + G  
Sbjct: 282 NCFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHS 341

Query: 533 CASR-CDCD-HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLP 590
            A R C+C  H+  C              G  C   C     G +C              
Sbjct: 342 HACRKCECHGHTHSCHFDMAVYLASGNVSGGVCD-GCQHNTAGRHCE------------- 387

Query: 591 ENGNCVCAPGF--------RGPSCQRSCQPGRYGKRCVPCKCANHSFCHPS----NGTCY 638
                +C P F        R P+  RSC     G +    +C +H    P+    +G C 
Sbjct: 388 -----LCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGG-RCDSHD--DPALGLVSGQCR 439

Query: 639 CLAGWTGPDCSQPCPPGHWGENCA-----QTCQCHHGGT------CHPQDGSCICPLGWT 687
           C     G  C Q C  G +G + +     + CQC+  GT      C P  GSC C    T
Sbjct: 440 CKEHVVGTRCQQ-CRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVT 498

Query: 688 GHHCLEGCPLGTFGANCS----QPCQCGPG----EKCHPETGACVCPPGHSGAPC 734
           G  C + C  G +G +      +PC C  G     +C   TG C C     G  C
Sbjct: 499 GRGC-DRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRC 552



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 17/42 (40%), Positives = 21/42 (50%), Gaps = 4/42 (9%)

Query: 697 LGTFGANCSQPCQCGP----GEKCHPETGACVCPPGHSGAPC 734
           L T   N + PCQC P      +C+P  G C+C PG  G  C
Sbjct: 772 LSTLIYNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRC 813


>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
          Length = 3075

 Score =  155 bits (392), Expect = 2e-37
 Identities = 141/462 (30%), Positives = 176/462 (38%), Gaps = 95/462 (20%)

Query: 248  CSCPPGWMGTICSLPCPEGFH-------GPNCSQECRCHNGGLCDRFTGQC-RCAPGYTG 299
            C CP G+ GT C   C  G++       G  C Q C CH         G C  CA   TG
Sbjct: 709  CECPQGYTGTSCE-SCLSGYYRVDGILFGGIC-QPCECHGHAAECNVHGVCIACAHNTTG 766

Query: 300  DRCREECPVGRFGQDCAETC-DCAPDA------------RCFPANG---AC-LCEHGFTG 342
              C E+C  G +G+    T  DC P A             C   +G    C  C  G++G
Sbjct: 767  VHC-EQCLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYSG 825

Query: 343  DRCTDRLCPDGFYGL------SCQAPCTC----DREHSLSCHPMNGEC-SCLPGWAGLHC 391
              C    C DG+YG       SC  PC C    D   +  C  + GEC  CL    G HC
Sbjct: 826  AWC--ERCADGYYGNPTVPGESC-VPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHC 882

Query: 392  NESCPQDTHGPG--------CQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTY 443
             E C    +G          C+ H    H  VC   +GLC C P  TG  C   C    Y
Sbjct: 883  -ERCADGFYGDAVTAKNCRACECHVKGSHSAVCHLETGLCDCKPNVTGQQC-DQCLHGYY 940

Query: 444  GVNCSARC-SCENAIACSPID-----GECVCKEGWQRGNCSVPCPPGTWGF---SCNASC 494
            G++    C  C  ++A S  D     G+C C  G     C   C  G + +   SC   C
Sbjct: 941  GLDSGHGCRPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRCD-RCAHGFYAYQDGSC-TPC 998

Query: 495  QCAH-EAVCSPQTGACTCTPGWHGAHCQLPCPKGQFG----EGCASRCDC----DHSDGC 545
             C H +  C P+TG C C P   G  C+  C  G +G     GC + C+C         C
Sbjct: 999  DCPHTQNTCDPETGECVCPPHTQGVKCE-ECEDGHWGYDAEVGCQA-CNCSLVGSTHHRC 1056

Query: 546  DPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGT-------------CLPEN 592
            D V G CQC++ + G  C   C  G         C C   GT             C+ E 
Sbjct: 1057 DVVTGHCQCKSKFGGRACD-QCSLGYRDFPDCVPCDCDLRGTSGDACNLEQGLCGCVEET 1115

Query: 593  GNCVCAPGFRGPSCQRSCQPGRYGKR------CVPCKCANHS 628
            G C C     GP C   C+ G +  R      C PC C+  S
Sbjct: 1116 GACPCKENVFGPQC-NECREGTFALRADNPLGCSPCFCSGLS 1156



 Score =  146 bits (369), Expect = 9e-35
 Identities = 128/462 (27%), Positives = 172/462 (37%), Gaps = 97/462 (20%)

Query: 334  CLCEHGFTGDRCTDRLCPDGFY-------GLSCQAPCTCDREHSLSCHPMNGEC-SCLPG 385
            C C  G+TG  C    C  G+Y       G  CQ PC C   H+  C+ ++G C +C   
Sbjct: 709  CECPQGYTGTSCES--CLSGYYRVDGILFGGICQ-PCEC-HGHAAECN-VHGVCIACAHN 763

Query: 386  WAGLHCNESCP----QDTHG-PGCQEHCLCL-------HGGVCQATSG---LCQ-CAPGY 429
              G+HC +  P    + + G PG  + C C            C    G   +C  CAPGY
Sbjct: 764  TTGVHCEQCLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGY 823

Query: 430  TGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFS 489
            +G  C   C    YG       SC                         VPC        
Sbjct: 824  SGAWCER-CADGYYGNPTVPGESC-------------------------VPC-------D 850

Query: 490  CNASCQCAHEAVCSPQTGACT-CTPGWHGAHCQLPCPKGQFGEGCASR----CDC----D 540
            C+ +   +    C   TG C  C     GAHC+  C  G +G+   ++    C+C     
Sbjct: 851  CSGNVDPSEAGHCDSVTGECLKCLGNTDGAHCER-CADGFYGDAVTAKNCRACECHVKGS 909

Query: 541  HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSN---TCTCKNGGTC---LPENGN 594
            HS  C    G C C+    G +C   C  G +G++  +    C C   G+      + G 
Sbjct: 910  HSAVCHLETGLCDCKPNVTGQQCD-QCLHGYYGLDSGHGCRPCNCSVAGSVSDGCTDEGQ 968

Query: 595  CVCAPGFRGPSCQRSCQPGRYGKR---CVPCKCAN-HSFCHPSNGTCYCLAGWTGPDCSQ 650
            C C PG  G  C R C  G Y  +   C PC C +  + C P  G C C     G  C +
Sbjct: 969  CHCVPGVAGKRCDR-CAHGFYAYQDGSCTPCDCPHTQNTCDPETGECVCPPHTQGVKCEE 1027

Query: 651  PCPPGHWGENC---AQTCQCHHGGTCHPQ----DGSCICPLGWTGHHCLEGCPLGTFGAN 703
             C  GHWG +     Q C C   G+ H +     G C C   + G  C + C LG     
Sbjct: 1028 -CEDGHWGYDAEVGCQACNCSLVGSTHHRCDVVTGHCQCKSKFGGRAC-DQCSLGYRDFP 1085

Query: 704  CSQPCQCG----PGEKCHPETGACVCPPGHSGAPCRIGIQEP 741
               PC C      G+ C+ E G C C       PC+  +  P
Sbjct: 1086 DCVPCDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGP 1127



 Score =  132 bits (332), Expect = 2e-30
 Identities = 140/493 (28%), Positives = 182/493 (36%), Gaps = 117/493 (23%)

Query: 120  CQCVPGWRGDDCSSECAPG-------MWGPQCDKPCSC-GNNSSCDPKSGVCSCPSGLQP 171
            C+C  G+ G  C S C  G       ++G  C +PC C G+ + C+      +C      
Sbjct: 709  CECPQGYTGTSCES-CLSGYYRVDGILFGGIC-QPCECHGHAAECNVHGVCIACAHNTTG 766

Query: 172  PNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPS 231
             +C Q C PG+YG   +      G P D Q   C CP                S  F P+
Sbjct: 767  VHCEQ-CLPGFYGEPSR------GTPGDCQ--PCACPLTI------------ASNNFSPT 805

Query: 232  THSCQNGGVFQTPQGSCS-CPPGWMGTICSLPCPEGFHGP-----------NCSQECRCH 279
             H      V       C  C PG+ G  C   C +G++G            +CS      
Sbjct: 806  CHLNDGDEVV------CDWCAPGYSGAWCE-RCADGYYGNPTVPGESCVPCDCSGNVDPS 858

Query: 280  NGGLCDRFTGQC-RCAPGYTGDRCREECPVGRFG-----QDCAETCDC----APDARCFP 329
              G CD  TG+C +C     G  C E C  G +G     ++C   C+C    +  A C  
Sbjct: 859  EAGHCDSVTGECLKCLGNTDGAHC-ERCADGFYGDAVTAKNC-RACECHVKGSHSAVCHL 916

Query: 330  ANGACLCEHGFTGDRCTDRLCPDGFYGL----SCQAPCTCDREHSLS--CHPMNGECSCL 383
              G C C+   TG +C    C  G+YGL     C+ PC C    S+S  C    G+C C+
Sbjct: 917  ETGLCDCKPNVTGQQCDQ--CLHGYYGLDSGHGCR-PCNCSVAGSVSDGCTD-EGQCHCV 972

Query: 384  PGWAGLHCNESCPQD--THGPGCQEHCLCLH-GGVCQATSGLCQCAPGYTGPHCASLCPP 440
            PG AG  C + C      +  G    C C H    C   +G C C P   G  C   C  
Sbjct: 973  PGVAGKRC-DRCAHGFYAYQDGSCTPCDCPHTQNTCDPETGECVCPPHTQGVKCEE-CED 1030

Query: 441  DTYG----VNCSARCSC----ENAIACSPIDGECVCKEGWQRGNCS------------VP 480
              +G    V C A C+C         C  + G C CK  +    C             VP
Sbjct: 1031 GHWGYDAEVGCQA-CNCSLVGSTHHRCDVVTGHCQCKSKFGGRACDQCSLGYRDFPDCVP 1089

Query: 481  CP---PGTWGFSCNAS---CQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCA 534
            C     GT G +CN     C C  E      TGAC C     G  C   C +G F     
Sbjct: 1090 CDCDLRGTSGDACNLEQGLCGCVEE------TGACPCKENVFGPQCN-ECREGTFA---- 1138

Query: 535  SRCDCDHSDGCDP 547
                 D+  GC P
Sbjct: 1139 --LRADNPLGCSP 1149



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 85/314 (27%), Positives = 110/314 (35%), Gaps = 73/314 (23%)

Query: 82   TDHRQRLQCCHGFYESRGFCVPLCAQEC-VHGRCVA-----PNQCQCVPGWRGDDCSSEC 135
            TD     +C  GFY          A EC V G   A        C C P   G  C  +C
Sbjct: 877  TDGAHCERCADGFYGDAVTAKNCRACECHVKGSHSAVCHLETGLCDCKPNVTGQQCD-QC 935

Query: 136  APGMWGPQCD---KPCSC---GNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYY----GP 185
              G +G       +PC+C   G+ S      G C C  G+    C   C  G+Y    G 
Sbjct: 936  LHGYYGLDSGHGCRPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRC-DRCAHGFYAYQDGS 994

Query: 186  ACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQ 245
                 C      CDP+TG C CP    G  C+  C  G  G+   +   CQ         
Sbjct: 995  CTPCDCPHTQNTCDPETGECVCPPHTQGVKCE-ECEDGHWGY--DAEVGCQ--------- 1042

Query: 246  GSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREE 305
             +C                      NCS     H+   CD  TG C+C   + G  C ++
Sbjct: 1043 -AC----------------------NCSLVGSTHH--RCDVVTGHCQCKSKFGGRAC-DQ 1076

Query: 306  CPVG-RFGQDCAETCDC-----APDA--------RCFPANGACLCEHGFTGDRCTDRLCP 351
            C +G R   DC   CDC     + DA         C    GAC C+    G +C +  C 
Sbjct: 1077 CSLGYRDFPDCV-PCDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGPQCNE--CR 1133

Query: 352  DGFYGLSCQAPCTC 365
            +G + L    P  C
Sbjct: 1134 EGTFALRADNPLGC 1147



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 63/182 (34%), Positives = 73/182 (40%), Gaps = 44/182 (24%)

Query: 594  NCVCAPGFRGPSCQRSCQPGRY----------GKR-----CVPCKCANHS-FCHPSNGTC 637
            NCVC PG  G SCQ  C PG +          G R     CVPC C NHS  C P+ G C
Sbjct: 1361 NCVCPPGTVGFSCQ-DCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGKC 1419

Query: 638  YCLAGWTGPDCSQPCPPGHWGE------NCAQTCQCHH------GGTC---HPQDGSC-I 681
                  T  D    C  G++G+      +CA  C C H        TC      D  C  
Sbjct: 1420 LNCGDNTAGDHCDVCTSGYYGKVTGSASDCA-LCACPHSPPASFSPTCVLEGDHDFRCDA 1478

Query: 682  CPLGWTGHHCLEGCPLGTFG-----ANCSQPCQCGPGEKCHPE----TGACVCPPGHSGA 732
            C LG+ G HC E C    +G         Q C C P    H +    +G CVC  G SG 
Sbjct: 1479 CLLGYEGKHC-ERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASGL 1537

Query: 733  PC 734
             C
Sbjct: 1538 RC 1539



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 65/210 (30%), Positives = 79/210 (37%), Gaps = 52/210 (24%)

Query: 120  CQCVPGWRGDDCSSECAPGMW----------GPQ-----CDKPCSCGNNS-SCDPKSGVC 163
            C C PG  G  C  +CAPG            GP+     C  PCSC N+S +CDP +G C
Sbjct: 1362 CVCPPGTVGFSCQ-DCAPGYHRGKLPAGSDRGPRPLVAPC-VPCSCNNHSDTCDPNTGKC 1419

Query: 164  -SCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQ 222
             +C       +C   CT GYYG        C    C     A F P        D  C  
Sbjct: 1420 LNCGDNTAGDHC-DVCTSGYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCDA 1478

Query: 223  GTSGFFCPSTHSCQNG--GVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHN 280
               G+       C +   G  QTP GSC                         Q+C C+ 
Sbjct: 1479 CLLGYEGKHCERCSSSYYGNPQTPGGSC-------------------------QKCDCNP 1513

Query: 281  GGL----CDRFTGQCRCAPGYTGDRCREEC 306
             G     CDR +GQC C  G +G RC +EC
Sbjct: 1514 HGSVHGDCDRTSGQCVCRLGASGLRC-DEC 1542



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 73/270 (27%), Positives = 101/270 (37%), Gaps = 58/270 (21%)

Query: 148 CSC-GNNSSCD----PKSGVCSCPSGLQPPNCLQPCTPGYY-----------GPACQFRC 191
           C C G+ SSC      K   C C       +C + C PGY+           G  C+  C
Sbjct: 270 CICYGHASSCPWDETTKKLQCQCEHNTCGESCNR-CCPGYHQQPWRPGTVSSGNTCE-AC 327

Query: 192 QCHGAPCD--------PQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNG----- 238
            CH    D         Q  +     +  G    ++C Q T G  C    +C +G     
Sbjct: 328 NCHNKAKDCYYDESVAKQKKSLNTAGQFRGGGVCINCLQNTMGINC---ETCIDGYYRPH 384

Query: 239 ---GVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAP 295
                   P   C+C P  +G++ S+   +  H          HNG    +  GQC C  
Sbjct: 385 KVSPYEDEPCRPCNCDP--VGSLSSVCIKDDLHSD-------LHNG----KQPGQCPCKE 431

Query: 296 GYTGDRCREECPVGRFGQDCAETCDCAP--DARCFPANGACLCEHGFTGDRCTDRLCPDG 353
           GYTG++C + C +G        +C C P   A   P  G C+C+    G  C DR C  G
Sbjct: 432 GYTGEKC-DRCQLGYKDYPTCVSCGCNPVGSASDEPCTGPCVCKENVEGKAC-DR-CKPG 488

Query: 354 FYGLSCQAPCTCDREHSLSCHPMNGECSCL 383
           FY L  + P  C       C  ++  CS L
Sbjct: 489 FYNLKEKNPRGCS---ECFCFGVSDVCSSL 515



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 68/235 (28%), Positives = 85/235 (36%), Gaps = 65/235 (27%)

Query: 247  SCSCPPGWMGTICSLPCPEGFH----------GPNC----SQECRCHN-GGLCDRFTGQC 291
            +C CPPG +G  C   C  G+H          GP         C C+N    CD  TG+C
Sbjct: 1361 NCVCPPGTVGFSCQ-DCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGKC 1419

Query: 292  -RCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLC 350
              C     GD C + C  G +G+      DCA           C C H            
Sbjct: 1420 LNCGDNTAGDHC-DVCTSGYYGKVTGSASDCA----------LCACPHSPPA-------- 1460

Query: 351  PDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHG----PG--C 404
                   S    C  + +H   C       +CL G+ G HC E C    +G    PG  C
Sbjct: 1461 -------SFSPTCVLEGDHDFRCD------ACLLGYEGKHC-ERCSSSYYGNPQTPGGSC 1506

Query: 405  QEHCLCLHGGV---CQATSGLCQCAPGYTGPHCASLCPP-----DTYGVNCSARC 451
            Q+     HG V   C  TSG C C  G +G  C   C P     +T  V+C   C
Sbjct: 1507 QKCDCNPHGSVHGDCDRTSGQCVCRLGASGLRCDE-CEPRHILMETDCVSCDDEC 1560



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 60/206 (29%), Positives = 78/206 (37%), Gaps = 53/206 (25%)

Query: 481  CPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKG--QFGEGCASRCD 538
            CPPGT GFSC                    C PG+H         +G       C   C 
Sbjct: 1364 CPPGTVGFSCQ------------------DCAPGYHRGKLPAGSDRGPRPLVAPCVP-CS 1404

Query: 539  C-DHSDGCDPVHGRC-QCQAGWMGARCHLSCPEGLWG------VNCSNTCTCKN------ 584
            C +HSD CDP  G+C  C     G  C + C  G +G       +C+  C C +      
Sbjct: 1405 CNNHSDTCDPNTGKCLNCGDNTAGDHCDV-CTSGYYGKVTGSASDCA-LCACPHSPPASF 1462

Query: 585  GGTCLPENGN---C-VCAPGFRGPSCQRSCQPGRYGK------RCVPCKC----ANHSFC 630
              TC+ E  +   C  C  G+ G  C+R C    YG        C  C C    + H  C
Sbjct: 1463 SPTCVLEGDHDFRCDACLLGYEGKHCER-CSSSYYGNPQTPGGSCQKCDCNPHGSVHGDC 1521

Query: 631  HPSNGTCYCLAGWTGPDCSQPCPPGH 656
              ++G C C  G +G  C + C P H
Sbjct: 1522 DRTSGQCVCRLGASGLRCDE-CEPRH 1546



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 77/294 (26%), Positives = 101/294 (34%), Gaps = 77/294 (26%)

Query: 408 CLCL-HGGVC---QATSGL-CQCAPGYTGPHCASLCP--------PDTY--GVNCSARCS 452
           C+C  H   C   + T  L CQC     G  C   CP        P T   G  C A C+
Sbjct: 270 CICYGHASSCPWDETTKKLQCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSGNTCEA-CN 328

Query: 453 CENAIACSPIDGECVCKEG--------WQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSP 504
           C N       D E V K+         ++ G   + C   T G +C              
Sbjct: 329 CHNKAKDCYYD-ESVAKQKKSLNTAGQFRGGGVCINCLQNTMGINCE------------- 374

Query: 505 QTGACTCTPGWHGAH---------CQLPC---PKGQFGEGCASRCDCDHSD---GCDPVH 549
                TC  G++  H         C+ PC   P G     C    D  HSD   G  P  
Sbjct: 375 -----TCIDGYYRPHKVSPYEDEPCR-PCNCDPVGSLSSVCIK--DDLHSDLHNGKQP-- 424

Query: 550 GRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPE--NGNCVCAPGFRGPSCQ 607
           G+C C+ G+ G +C   C  G        +C C   G+   E   G CVC     G +C 
Sbjct: 425 GQCPCKEGYTGEKCD-RCQLGYKDYPTCVSCGCNPVGSASDEPCTGPCVCKENVEGKACD 483

Query: 608 RSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCL----------AGWTGPDCSQP 651
           R C+PG Y  +    +  +  FC   +  C  L          +GW   D   P
Sbjct: 484 R-CKPGFYNLKEKNPRGCSECFCFGVSDVCSSLSWPVGQVNSMSGWLVTDLISP 536



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 61/217 (28%), Positives = 75/217 (34%), Gaps = 52/217 (23%)

Query: 524  CPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCK 583
            CP G  G  C           C P + R +  AG       L  P           C+C 
Sbjct: 1364 CPPGTVGFSCQD---------CAPGYHRGKLPAGSDRGPRPLVAP--------CVPCSCN 1406

Query: 584  N-GGTCLPENGNCV-CAPGFRGPSCQRSCQPGRYGK------RCVPCKCANHSFCHPSNG 635
            N   TC P  G C+ C     G  C   C  G YGK       C  C C  HS     + 
Sbjct: 1407 NHSDTCDPNTGKCLNCGDNTAGDHCD-VCTSGYYGKVTGSASDCALCACP-HSPPASFSP 1464

Query: 636  TCY-----------CLAGWTGPDCSQPCPPGHWGE-----NCAQTCQCH-HG---GTCHP 675
            TC            CL G+ G  C + C   ++G         Q C C+ HG   G C  
Sbjct: 1465 TCVLEGDHDFRCDACLLGYEGKHCER-CSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDR 1523

Query: 676  QDGSCICPLGWTGHHCLEGCP----LGTFGANCSQPC 708
              G C+C LG +G  C E  P    + T   +C   C
Sbjct: 1524 TSGQCVCRLGASGLRCDECEPRHILMETDCVSCDDEC 1560



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 71/265 (26%), Positives = 91/265 (34%), Gaps = 69/265 (26%)

Query: 275 ECRC-HN--GGLCDRFTGQCRCAPGY-----------TGDRCREECPVGRFGQDC----- 315
           +C+C HN  G  C+R      C PGY           +G+ C E C      +DC     
Sbjct: 289 QCQCEHNTCGESCNR------CCPGYHQQPWRPGTVSSGNTC-EACNCHNKAKDCYYDES 341

Query: 316 -AETCDCAPDARCFPANGACL-CEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLS- 372
            A+       A  F   G C+ C     G  C    C DG+Y           R H +S 
Sbjct: 342 VAKQKKSLNTAGQFRGGGVCINCLQNTMGINC--ETCIDGYY-----------RPHKVSP 388

Query: 373 -----CHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAP 427
                C P    C+C P   G   +     D H          LH G      G C C  
Sbjct: 389 YEDEPCRP----CNCDP--VGSLSSVCIKDDLHSD--------LHNG---KQPGQCPCKE 431

Query: 428 GYTGPHC--ASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGT 485
           GYTG  C    L   D Y    S  C+   + +  P  G CVCKE  +   C   C PG 
Sbjct: 432 GYTGEKCDRCQLGYKD-YPTCVSCGCNPVGSASDEPCTGPCVCKENVEGKACD-RCKPGF 489

Query: 486 WGFSCNASCQCAHEAVCSPQTGACT 510
           +         C+ E  C   +  C+
Sbjct: 490 YNLKEKNPRGCS-ECFCFGVSDVCS 513



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 52/208 (25%), Positives = 69/208 (33%), Gaps = 38/208 (18%)

Query: 551 RCQCQAGWMGARCHLSCP---EGLW---GVNCSNTC----------TCKNGGTCLPENGN 594
           +CQC+    G  C+  CP   +  W    V+  NTC           C    +   +  +
Sbjct: 289 QCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSGNTCEACNCHNKAKDCYYDESVAKQKKS 348

Query: 595 CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPC-- 652
              A  FRG     +C     G  C  C      +  P   + Y        +  +PC  
Sbjct: 349 LNTAGQFRGGGVCINCLQNTMGINCETC---IDGYYRPHKVSPY------EDEPCRPCNC 399

Query: 653 -PPGHWGENCAQT---CQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPC 708
            P G     C +       H+G     Q G C C  G+TG  C + C LG         C
Sbjct: 400 DPVGSLSSVCIKDDLHSDLHNG----KQPGQCPCKEGYTGEKC-DRCQLGYKDYPTCVSC 454

Query: 709 QCGP--GEKCHPETGACVCPPGHSGAPC 734
            C P       P TG CVC     G  C
Sbjct: 455 GCNPVGSASDEPCTGPCVCKENVEGKAC 482



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 61/232 (26%), Positives = 80/232 (34%), Gaps = 63/232 (27%)

Query: 334  CLCEHGFTGDRCTDRLCPDGFYGLSCQA--------------PCTCDREHSLSCHPMNGE 379
            C+C  G  G  C D  C  G++     A              PC+C+  HS +C P  G+
Sbjct: 1362 CVCPPGTVGFSCQD--CAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNN-HSDTCDPNTGK 1418

Query: 380  C-SCLPGWAGLHCNESCPQDTHGP--GCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCAS 436
            C +C    AG HC + C    +G   G    C             LC C      PH   
Sbjct: 1419 CLNCGDNTAGDHC-DVCTSGYYGKVTGSASDC------------ALCAC------PHS-- 1457

Query: 437  LCPPDTYGVNCSARCSCENAIACSPIDGEC-VCKEGWQRGNC-----SVPCPPGTWGFSC 490
              PP ++   C         +     D  C  C  G++  +C     S    P T G SC
Sbjct: 1458 --PPASFSPTC---------VLEGDHDFRCDACLLGYEGKHCERCSSSYYGNPQTPGGSC 1506

Query: 491  NASCQC-AHEAV---CSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCD 538
               C C  H +V   C   +G C C  G  G  C    P+    E     CD
Sbjct: 1507 Q-KCDCNPHGSVHGDCDRTSGQCVCRLGASGLRCDECEPRHILMETDCVSCD 1557



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 25/86 (29%), Positives = 34/86 (39%), Gaps = 9/86 (10%)

Query: 117 PNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCG--NNSSCDPKSGVCSCPSGLQPPNC 174
           P QC C  G+ G+ C   C  G         C C    ++S +P +G C C   ++   C
Sbjct: 424 PGQCPCKEGYTGEKC-DRCQLGYKDYPTCVSCGCNPVGSASDEPCTGPCVCKENVEGKAC 482

Query: 175 LQPCTPGYY-----GPACQFRCQCHG 195
              C PG+Y      P     C C G
Sbjct: 483 -DRCKPGFYNLKEKNPRGCSECFCFG 507



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 30/89 (33%), Positives = 35/89 (39%), Gaps = 19/89 (21%)

Query: 103  PLCAQECVHG-RCVAPNQCQCVPGWRGDDCSSECAPGMWG-PQ-----CDKPCSCGNNSS 155
            P C  E  H  RC A     C+ G+ G  C   C+   +G PQ     C K C C  + S
Sbjct: 1464 PTCVLEGDHDFRCDA-----CLLGYEGKHCE-RCSSSYYGNPQTPGGSCQK-CDCNPHGS 1516

Query: 156  ----CDPKSGVCSCPSGLQPPNCLQPCTP 180
                CD  SG C C  G     C   C P
Sbjct: 1517 VHGDCDRTSGQCVCRLGASGLRC-DECEP 1544


>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
          Length = 685

 Score =  149 bits (375), Expect = 2e-35
 Identities = 127/442 (28%), Positives = 176/442 (39%), Gaps = 77/442 (17%)

Query: 349 LCPDGFYGLSCQAPCTCDREH--SLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQE 406
           +C D +YG +C   C    +H     C P +G  SCLPGW G    E C Q     GC E
Sbjct: 174 ICSDNYYGDNCSRLCKKRNDHFGHYVCQP-DGNLSCLPGWTG----EYCQQPICLSGCHE 228

Query: 407 HCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGEC 466
                  G C   +  C C PG+ G  C    P +           C +    +P   +C
Sbjct: 229 Q-----NGYCSKPAE-CLCRPGWQGRLCNECIPHN----------GCRHGTCSTP--WQC 270

Query: 467 VCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPK 526
            C EGW    C       T    C     C++      ++  CTC PG+ G  C+L   +
Sbjct: 271 TCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG---QRSYTCTCRPGYTGVDCELELSE 327

Query: 527 GQFGEGCASRCDC-DHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNG 585
                 C +   C D  DG       C C  G+ G  C  S       ++C+++  C NG
Sbjct: 328 CD-SNPCRNGGSCKDQEDGY-----HCLCPPGYYGLHCEHST------LSCADS-PCFNG 374

Query: 586 GTCLPENGN----CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFC---HPSNGTCY 638
           G+C   N      C C P F G +C++         RC    CAN   C    PS   C 
Sbjct: 375 GSCRERNQGANYACECPPNFTGSNCEKKVD------RCTSNPCANGGQCLNRGPSR-MCR 427

Query: 639 CLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGS--CICPLGWTGHHCLEGCP 696
           C  G+TG  C           +CA+   C HGGTCH  +    C CP G++G  C     
Sbjct: 428 CRPGFTGTYCELHV------SDCARN-PCAHGGTCHDLENGLMCTCPAGFSGRRCEVRT- 479

Query: 697 LGTFGANCSQPC--QCGPGEKCHPETGACVCPPGHSGAPCRIGIQEPFTVMPTTPVAYNS 754
             +  A  S PC  +         +T  C CP G  G+ C      P  + P+ P    S
Sbjct: 480 --SIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEF----PVGLPPSFPWVAVS 533

Query: 755 LGAVIGIAVLGSLVVALVALFI 776
           LG  +G+AVL  +++ +VA+ +
Sbjct: 534 LG--VGLAVL-LVLLGMVAVAV 552



 Score =  129 bits (325), Expect = 1e-29
 Identities = 105/388 (27%), Positives = 147/388 (37%), Gaps = 87/388 (22%)

Query: 263 CPEGFHGPNCSQECRCHN---GGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETC 319
           C + ++G NCS+ C+  N   G    +  G   C PG+TG+ C++  P+      C   C
Sbjct: 175 CSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQ--PI------CLSGC 226

Query: 320 DCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGE 379
                    PA   CLC  G+ G  C + +  +G    +C  P                +
Sbjct: 227 HEQNGYCSKPAE--CLCRPGWQGRLCNECIPHNGCRHGTCSTPW---------------Q 269

Query: 380 CSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCA---- 435
           C+C  GW GL C++     TH   C+    C + G     S  C C PGYTG  C     
Sbjct: 270 CTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG---QRSYTCTCRPGYTGVDCELELS 326

Query: 436 ---------------------SLCPPDTYGVNCS-ARCSCENAIACSPIDGECVCKEGWQ 473
                                 LCPP  YG++C  +  SC    A SP      C+E  Q
Sbjct: 327 ECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC----ADSPCFNGGSCRERNQ 382

Query: 474 RGNCSVPCPPGTWGFSCN------ASCQCAHEAVCSPQ--TGACTCTPGWHGAHCQLPCP 525
             N +  CPP   G +C        S  CA+   C  +  +  C C PG+ G +C+L   
Sbjct: 383 GANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHV- 441

Query: 526 KGQFGEGCASRCDCDHSDGCDPVHG--RCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCK 583
                  CA R  C H   C  +     C C AG+ G RC +        ++   +  C 
Sbjct: 442 -----SDCA-RNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRT-----SIDACASSPCF 490

Query: 584 NGGTCLPENGN----CVCAPGFRGPSCQ 607
           N  TC  +       C C  GF G  C+
Sbjct: 491 NRATCYTDLSTDTFVCNCPYGFVGSRCE 518



 Score =  115 bits (288), Expect = 2e-25
 Identities = 118/429 (27%), Positives = 152/429 (35%), Gaps = 115/429 (26%)

Query: 87  RLQCCHGFYESRGFCVPLCAQECVHGR---CVAPNQCQCVPGWRGDDCSSECAPGMWGPQ 143
           R+ C   +Y     C  LC +   H     C       C+PGW G+ C          P 
Sbjct: 172 RVICSDNYYGDN--CSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQ--------PI 221

Query: 144 CDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTG 203
           C         S C  ++G CS     +P  CL  C PG+ G  C   C  H   C  + G
Sbjct: 222 C--------LSGCHEQNGYCS-----KPAECL--CRPGWQGRLCN-ECIPHNG-C--RHG 262

Query: 204 ACFCPAERTGPSCDVSCSQGTSGFFCPS-----TH--SCQNGGVFQTP---QGSCSCPPG 253
            C  P + T       C +G  G FC       TH   C+NG           +C+C PG
Sbjct: 263 TCSTPWQCT-------CDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPG 315

Query: 254 WMGTICSLPCPEGFHGPNCSQECRCHNGGLC-DRFTG-QCRCAPGYTGDRCREECPVGRF 311
           + G  C L   E    P       C NGG C D+  G  C C PGY G  C         
Sbjct: 316 YTGVDCELELSECDSNP-------CRNGGSCKDQEDGYHCLCPPGYYGLHCEH------- 361

Query: 312 GQDCAETCDCAPDARCF----------PANGACLCEHGFTG-------DRCTDRLCPDGF 354
                 T  CA D+ CF           AN AC C   FTG       DRCT   C +G 
Sbjct: 362 -----STLSCA-DSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGG 415

Query: 355 YGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGG 414
             L+ + P              +  C C PG+ G +C      + H   C  +  C HGG
Sbjct: 416 QCLN-RGP--------------SRMCRCRPGFTGTYC------ELHVSDCARN-PCAHGG 453

Query: 415 VCQATSG--LCQCAPGYTGPHCASLCPPDTYGVN-CSARCSCENAIACSPIDGECVCKEG 471
            C       +C C  G++G  C      D    + C  R +C   ++       C C  G
Sbjct: 454 TCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTF--VCNCPYG 511

Query: 472 WQRGNCSVP 480
           +    C  P
Sbjct: 512 FVGSRCEFP 520



 Score =  103 bits (257), Expect = 8e-22
 Identities = 97/343 (28%), Positives = 125/343 (36%), Gaps = 74/343 (21%)

Query: 83  DHRQRLQCCHGFYESRGFCVP----LC--------AQECV------HGRCVAPNQCQCVP 124
           ++ Q+  C  G +E  G+C      LC          EC+      HG C  P QC C  
Sbjct: 215 EYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDE 274

Query: 125 GWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYG 184
           GW G  C  +               C ++S C  K+G     SG +   C   C PGY G
Sbjct: 275 GWGGLFCDQDLN------------YCTHHSPC--KNGATCSNSGQRSYTC--TCRPGYTG 318

Query: 185 PACQFR-CQCHGAPC-------DPQTG-ACFCPAERTGPSCD---VSCSQGTSGFFCPST 232
             C+    +C   PC       D + G  C CP    G  C+   +SC+       C + 
Sbjct: 319 VDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP----CFNG 374

Query: 233 HSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRF--TGQ 290
            SC+     Q    +C CPP + G+ C          P       C NGG C     +  
Sbjct: 375 GSCRERN--QGANYACECPPNFTGSNCEKKVDRCTSNP-------CANGGQCLNRGPSRM 425

Query: 291 CRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFP-ANG-ACLCEHGFTGDRCTDR 348
           CRC PG+TG  C           DCA    CA    C    NG  C C  GF+G RC  R
Sbjct: 426 CRCRPGFTGTYCELHV------SDCARN-PCAHGGTCHDLENGLMCTCPAGFSGRRCEVR 478

Query: 349 LCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHC 391
              D      C    TC  + S         C+C  G+ G  C
Sbjct: 479 TSIDACASSPCFNRATCYTDLSTDTF----VCNCPYGFVGSRC 517


>gi|110611156 laminin, gamma 3 precursor [Homo sapiens]
          Length = 1575

 Score =  146 bits (369), Expect = 9e-35
 Identities = 122/418 (29%), Positives = 157/418 (37%), Gaps = 95/418 (22%)

Query: 120  CQCVPGWRGDDCSSECAPG------MWGPQCD-KPCSCGNNSSCDPKSGVCSCPSGLQPP 172
            C C  G+ G  C S CAPG        GP     PC+C  + +CDP +G+C C    + P
Sbjct: 673  CSCPTGYTGQFCES-CAPGYKREMPQGGPYASCVPCTCNQHGTCDPNTGICVCSHHTEGP 731

Query: 173  NCLQPCTPGYYG-PACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPS 231
            +C + C PG+YG P       C   PC  Q+     P  R     +V C           
Sbjct: 732  SC-ERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESR-----EVVC----------- 774

Query: 232  THSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHG--------PNCSQECRCHNG-- 281
            TH                CPPG  G  C + C +GF G        P    +C+C     
Sbjct: 775  TH----------------CPPGQRGRRCEV-CDDGFFGDPLGLFGHPQPCHQCQCSGNVD 817

Query: 282  ----GLCDRFTGQC-RCAPGYTGDRCREECPVGRFGQ-------DCAETCDCAPDAR--- 326
                G CD  +G C RC    TGD C E C  G +G        D    C C P      
Sbjct: 818  PNAVGNCDPLSGHCLRCLHNTTGDHC-EHCQEGFYGSALAPRPADKCMPCSCHPQGSVSE 876

Query: 327  ---CFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSL-----SCHPMNG 378
               C P  G C C    T   C+   C  GF+ L     C   + H L      CHP  G
Sbjct: 877  QMPCDPVTGQCSCLPHVTARDCS--RCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTG 934

Query: 379  ECSCLPGWAGLHCNESCPQDTHG---PGCQEHCLCLHGGVCQA---TSGLCQCAPGYTGP 432
            +C+C PG  G  C + C     G    GC+  C C   G   A    +G C C PG+ G 
Sbjct: 935  QCTCRPGVTGQAC-DRCQLGFFGFSIKGCRA-CRCSPLGAASAQCHENGTCVCRPGFEGY 992

Query: 433  HCASLCPPDTY----GVNCSARCSCENAI--ACSPIDGECVCKEGWQRG-NCSVPCPP 483
             C   C  + +    G +C    SC   +    + +       EGW +G +C  P  P
Sbjct: 993  KC-DRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGP 1049



 Score =  136 bits (343), Expect = 9e-32
 Identities = 107/367 (29%), Positives = 138/367 (37%), Gaps = 98/367 (26%)

Query: 422 LCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPC 481
           +C C  GYTG  C S                               C  G++R       
Sbjct: 672 ICSCPTGYTGQFCES-------------------------------CAPGYKR-----EM 695

Query: 482 PPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASR----- 536
           P G    SC   C C     C P TG C C+    G  C+  C  G +G   A +     
Sbjct: 696 PQGGPYASC-VPCTCNQHGTCDPNTGICVCSHHTEGPSCER-CLPGFYGNPFAGQADDCQ 753

Query: 537 -CDCDHSDGCDPVHGRCQ-----CQAGWMGARCHLSCPEGLWG--------------VNC 576
            C C     C  +    +     C  G  G RC + C +G +G                C
Sbjct: 754 PCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEV-CDDGFFGDPLGLFGHPQPCHQCQC 812

Query: 577 SNTCTCKNGGTCLPENGNCV-CAPGFRGPSCQRSCQPGRYGK--------RCVPCKC--- 624
           S        G C P +G+C+ C     G  C+  CQ G YG         +C+PC C   
Sbjct: 813 SGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEH-CQEGFYGSALAPRPADKCMPCSCHPQ 871

Query: 625 ---ANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHW----GENCAQTCQCHHGGT----C 673
              +    C P  G C CL   T  DCS+ C PG +    G  C ++C+CH  G+    C
Sbjct: 872 GSVSEQMPCDPVTGQCSCLPHVTARDCSR-CYPGFFDLQPGRGC-RSCKCHPLGSQEDQC 929

Query: 674 HPQDGSCICPLGWTGHHCLEGCPLGTFGANCS--QPCQCGP----GEKCHPETGACVCPP 727
           HP+ G C C  G TG  C + C LG FG +    + C+C P      +CH E G CVC P
Sbjct: 930 HPKTGQCTCRPGVTGQAC-DRCQLGFFGFSIKGCRACRCSPLGAASAQCH-ENGTCVCRP 987

Query: 728 GHSGAPC 734
           G  G  C
Sbjct: 988 GFEGYKC 994



 Score =  131 bits (330), Expect = 3e-30
 Identities = 125/457 (27%), Positives = 158/457 (34%), Gaps = 130/457 (28%)

Query: 248  CSCPPGWMGTICSLPCPEGFH------GPNCS-QECRCHNGGLCDRFTGQCRCAPGYTGD 300
            CSCP G+ G  C   C  G+       GP  S   C C+  G CD  TG C C+    G 
Sbjct: 673  CSCPTGYTGQFCE-SCAPGYKREMPQGGPYASCVPCTCNQHGTCDPNTGICVCSHHTEGP 731

Query: 301  RCREECPVGRFGQ------DCAETCDCAPDARC--FPANGACLCEH---GFTGDRCTDRL 349
             C E C  G +G       D  + C C   + C   P +   +C H   G  G RC   +
Sbjct: 732  SC-ERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRC--EV 788

Query: 350  CPDGFYG------------LSCQAPCTCDREHSLSCHPMNGEC-SCLPGWAGLHCNESCP 396
            C DGF+G              CQ     D     +C P++G C  CL    G HC E C 
Sbjct: 789  CDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHC-EHCQ 847

Query: 397  QDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENA 456
            +  +G                              P  A  C P     +C  + S    
Sbjct: 848  EGFYGSAL--------------------------APRPADKCMP----CSCHPQGSVSEQ 877

Query: 457  IACSPIDGECVCKEGWQRGNCSVPCPPGTW----GFSCNASCQC----AHEAVCSPQTGA 508
            + C P+ G+C C       +CS  C PG +    G  C  SC+C    + E  C P+TG 
Sbjct: 878  MPCDPVTGQCSCLPHVTARDCS-RCYPGFFDLQPGRGCR-SCKCHPLGSQEDQCHPKTGQ 935

Query: 509  CTCTPGWHGAHCQLPCPKGQFG---EGCASRCDCDHSDGCDPVHGRCQCQ-AGWMGARCH 564
            CTC PG  G  C   C  G FG   +GC +                C+C   G   A+CH
Sbjct: 936  CTCRPGVTGQACD-RCQLGFFGFSIKGCRA----------------CRCSPLGAASAQCH 978

Query: 565  LSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRS------CQPGRYGKR 618
                                      ENG CVC PGF G  C R          G + ++
Sbjct: 979  --------------------------ENGTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQ 1012

Query: 619  CVPCKCANHSFCHPSNGTCYCLAGW-TGPDCSQPCPP 654
            C  C                   GW  G DC  P  P
Sbjct: 1013 CPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGP 1049



 Score =  117 bits (294), Expect = 4e-26
 Identities = 178/712 (25%), Positives = 234/712 (32%), Gaps = 192/712 (26%)

Query: 89   QCCHGFY--ESRGFCVPLCAQEC--VHGRCVAPNQCQCVP---GWRGDDCSSECAPGMWG 141
            +C   FY  + R  C P   Q    +H +C     C C P   GW+ D     C PG   
Sbjct: 366  RCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCD----RCLPGFHS 421

Query: 142  PQ---CDKPCSC---GNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHG 195
                 C +PC+C   G+  +CDP+SG C C   ++  N    C PG +         C  
Sbjct: 422  LSEGGC-RPCTCNPAGSLDTCDPRSGRCPCKENVE-GNLCDRCRPGTFNLQPHNPAGCSS 479

Query: 196  APCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQN------GGVFQTPQG--S 247
              C   +  C   A+           QG  G++  S    ++       GV  +P+    
Sbjct: 480  CFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVGGSEHPPQWSPNGVLLSPEDEEE 539

Query: 248  CSCPPGWMG---------TICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYT 298
             + P  ++G          I +   P G        + R    GL           P   
Sbjct: 540  LTAPEKFLGDQRFSYGQPLILTFRVPPG--DSPLPVQLRLEGTGLALSLRHSSLSGPQDA 597

Query: 299  GDRCREECPVGRFG-QDCAETCDCAPDARCF---------------------PANGACLC 336
            G     E    RF  Q+ +E  D AP    F                     PA    L 
Sbjct: 598  GHPREVEL---RFHLQETSE--DVAPPLPPFHFQRLLANLTSLRLRVSPGPSPAGPVFLT 652

Query: 337  EHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSC-------HPMNGE-CSCLPGWAG 388
            E   T  R    L P   +   C  P     +   SC        P  G   SC+P    
Sbjct: 653  EVRLTSAR--PGLSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCN 710

Query: 389  LH--CNES-----CPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASL---C 438
             H  C+ +     C   T GP C+                  +C PG+ G   A     C
Sbjct: 711  QHGTCDPNTGICVCSHHTEGPSCE------------------RCLPGFYGNPFAGQADDC 752

Query: 439  PPDTYGVNCSARCSCENAIACS--PIDGECVCKEGWQRGNCSVPCPPGTWGFSCNA---- 492
             P          C C    AC+  P   E VC            CPPG  G  C      
Sbjct: 753  QP----------CPCPGQSACTTIPESREVVCTH----------CPPGQRGRRCEVCDDG 792

Query: 493  ----------------SCQCAHE------AVCSPQTGAC-TCTPGWHGAHCQLPCPKGQF 529
                             CQC+          C P +G C  C     G HC+  C +G +
Sbjct: 793  FFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCE-HCQEGFY 851

Query: 530  GEGCASR-------CDCDHSDG-------CDPVHGRCQCQAGWMGARCHLSCPEGLW--- 572
            G   A R       C C H  G       CDPV G+C C        C   C  G +   
Sbjct: 852  GSALAPRPADKCMPCSC-HPQGSVSEQMPCDPVTGQCSCLPHVTARDCS-RCYPGFFDLQ 909

Query: 573  -GVNCSNTCTCKNGGT----CLPENGNCVCAPGFRGPSCQRSCQPGRYG---KRCVPCKC 624
             G  C  +C C   G+    C P+ G C C PG  G +C R CQ G +G   K C  C+C
Sbjct: 910  PGRGC-RSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDR-CQLGFFGFSIKGCRACRC 967

Query: 625  ----ANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHW----GENCAQTCQCH 668
                A  + CH  NGTC C  G+ G  C + C    +    G +C Q   C+
Sbjct: 968  SPLGAASAQCH-ENGTCVCRPGFEGYKCDR-CHDNFFLTADGTHCQQCPSCY 1017



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 41/119 (34%), Positives = 51/119 (42%), Gaps = 22/119 (18%)

Query: 637 CYCLAGWTGPDCSQPCPPGHWGE--------NCAQTCQCHHGGTCHPQDGSCICPLGWTG 688
           C C  G+TG  C + C PG+  E        +C   C C+  GTC P  G C+C     G
Sbjct: 673 CSCPTGYTGQFC-ESCAPGYKREMPQGGPYASCVP-CTCNQHGTCDPNTGICVCSHHTEG 730

Query: 689 HHCLEGCPLGTFG------ANCSQPCQCGPGEKCH--PETGACVC---PPGHSGAPCRI 736
             C E C  G +G      A+  QPC C     C   PE+   VC   PPG  G  C +
Sbjct: 731 PSC-ERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEV 788



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 59/244 (24%), Positives = 78/244 (31%), Gaps = 59/244 (24%)

Query: 536 RCDCD-HSDGCDP-VHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENG 593
           RC C+ H+  C P V G+  C+           C     G +C                 
Sbjct: 270 RCKCNGHASECGPDVAGQLACR-----------CQHNTTGTDCER--------------- 303

Query: 594 NCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSF----------CHPSNGTCY-CLAG 642
              C P F+     R      +   C+PC C+  S                G C+ C   
Sbjct: 304 ---CLPFFQDRPWARGTAEAAH--ECLPCNCSGRSEECTFDRELFRSTGHGGRCHHCRDH 358

Query: 643 WTGPDCSQPCPPG--HWGENC-AQTCQCHHGGTCHPQ---DGSCICP---LGWTGHHCLE 693
             GP C + C     HW      Q C C   G+ H Q    G+C C     GW    CL 
Sbjct: 359 TAGPHCER-CQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLP 417

Query: 694 GCPLGTFGANCSQPCQCGPG---EKCHPETGACVCPPGHSGAPCRIGIQEPFTVMPTTPV 750
           G    +      +PC C P    + C P +G C C     G  C       F + P  P 
Sbjct: 418 G--FHSLSEGGCRPCTCNPAGSLDTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPA 475

Query: 751 AYNS 754
             +S
Sbjct: 476 GCSS 479



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 64/252 (25%), Positives = 80/252 (31%), Gaps = 69/252 (27%)

Query: 413 GGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGW 472
           GG C+      +C P   G   A  C  +T G +C           C P   +      W
Sbjct: 268 GGRCKCNGHASECGPDVAG-QLACRCQHNTTGTDCER---------CLPFFQD----RPW 313

Query: 473 QRGNCSVP--CPPGTWGFSCNASC---QCAHEAVCSPQTG----ACTCTPGWHGAHCQ-- 521
            RG       C P      CN S    +C  +      TG       C     G HC+  
Sbjct: 314 ARGTAEAAHECLP------CNCSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERC 367

Query: 522 ----------LPCPKGQFGEGCASRCDCDHSDG----CDPVHGRCQCQAGWMGARCHLSC 567
                     +PC            CDC  +      CD   G C C+    G +C    
Sbjct: 368 QENFYHWDPRMPCQP----------CDCQSAGSLHLQCDDT-GTCACKPTVTGWKCDRCL 416

Query: 568 P--EGLWGVNCSNTCTCKNGG---TCLPENGNCVCAPGFRGPSCQRSCQPGRYGKR---- 618
           P    L    C   CTC   G   TC P +G C C     G  C R C+PG +  +    
Sbjct: 417 PGFHSLSEGGC-RPCTCNPAGSLDTCDPRSGRCPCKENVEGNLCDR-CRPGTFNLQPHNP 474

Query: 619 --CVPCKCANHS 628
             C  C C  HS
Sbjct: 475 AGCSSCFCYGHS 486



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 53/209 (25%), Positives = 74/209 (35%), Gaps = 44/209 (21%)

Query: 90   CCHGFYESRGFCVPLCAQECVHGRC-------------VAPNQCQCVPGWRGDDCSSECA 136
            C  GFY S     P  A +C+   C                 QC C+P     DC S C 
Sbjct: 846  CQEGFYGSA--LAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDC-SRCY 902

Query: 137  PGMWGPQCDKPC-SC------GNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQF 189
            PG +  Q  + C SC           C PK+G C+C  G+    C   C  G++G + + 
Sbjct: 903  PGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQAC-DRCQLGFFGFSIK- 960

Query: 190  RCQCHGAPCDP---------QTGACFCPAERTGPSCD------VSCSQGTSGFFCPSTHS 234
               C    C P         + G C C     G  CD         + GT    CPS ++
Sbjct: 961  --GCRACRCSPLGAASAQCHENGTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSCYA 1018

Query: 235  CQNGGVFQTPQGSCSCPPGWM-GTICSLP 262
                   +  +   +   GW+ G+ C  P
Sbjct: 1019 LVKEEAAKL-KARLTLTEGWLQGSDCGSP 1046



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 71/291 (24%), Positives = 89/291 (30%), Gaps = 91/291 (31%)

Query: 320 DCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGE 379
           +C PD        AC C+H  TG  C +R  P  F+     A  T +  H          
Sbjct: 279 ECGPDVA---GQLACRCQHNTTGTDC-ERCLP--FFQDRPWARGTAEAAHE--------- 323

Query: 380 CSCLPGWAGLHCNESCPQDTHGPGCQEHCL--------CLHGGVCQATSGLCQCAPGYTG 431
             CLP      CN S        G  E C           HGG C        C     G
Sbjct: 324 --CLP------CNCS--------GRSEECTFDRELFRSTGHGGRCH------HCRDHTAG 361

Query: 432 PHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCN 491
           PHC                                 C+E +   +  +PC P     + +
Sbjct: 362 PHCER-------------------------------CQENFYHWDPRMPCQPCDCQSAGS 390

Query: 492 ASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPK-GQFGEGCASRCDCDHS---DGCDP 547
              QC         TG C C P   G  C    P      EG    C C+ +   D CDP
Sbjct: 391 LHLQC-------DDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLDTCDP 443

Query: 548 VHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCA 598
             GRC C+    G  C   C  G + +   N   C    +C     + VCA
Sbjct: 444 RSGRCPCKENVEGNLCD-RCRPGTFNLQPHNPAGC---SSCFCYGHSKVCA 490



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 63/233 (27%), Positives = 85/233 (36%), Gaps = 53/233 (22%)

Query: 190 RCQC--HGAPCDPQTG---ACFCPAERTGPSC--------DVSCSQGTSGFFCPSTHSCQ 236
           RC+C  H + C P      AC C    TG  C        D   ++GT+     + H C 
Sbjct: 270 RCKCNGHASECGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTA----EAAHECL 325

Query: 237 -------------NGGVFQTPQ--GSCS-CPPGWMGTICSLPCPEGFH--GPNCS-QECR 277
                        +  +F++    G C  C     G  C   C E F+   P    Q C 
Sbjct: 326 PCNCSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCER-CQENFYHWDPRMPCQPCD 384

Query: 278 CHNGGL----CDRFTGQCRCAPGYTGDRCREECPVG--RFGQDCAETCDCAPDA---RCF 328
           C + G     CD  TG C C P  TG +C + C  G     +     C C P      C 
Sbjct: 385 CQSAGSLHLQCDD-TGTCACKPTVTGWKC-DRCLPGFHSLSEGGCRPCTCNPAGSLDTCD 442

Query: 329 PANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECS 381
           P +G C C+    G+ C DR C  G + L    P  C    S  C+  +  C+
Sbjct: 443 PRSGRCPCKENVEGNLC-DR-CRPGTFNLQPHNPAGCS---SCFCYGHSKVCA 490


>gi|167614504 laminin, beta 1 precursor [Homo sapiens]
          Length = 1786

 Score =  143 bits (361), Expect = 7e-34
 Identities = 132/446 (29%), Positives = 166/446 (37%), Gaps = 90/446 (20%)

Query: 319  CDCAPDAR----CFPANGACLCEHGFTGDRCTDRLCPDGF-YGLSCQAPCTCDREHSLS- 372
            C+C P       C P  G C C     G  C +R  P  F +G S   PC C  + S++ 
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTC-NRCAPGTFGFGPSGCKPCECHLQGSVNA 831

Query: 373  -CHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCL-HGGVCQATSGLCQCAPGYT 430
             C+P+ G+C C  G     C+   P     P CQ  C C  H   C   +G C     YT
Sbjct: 832  FCNPVTGQCHCFQGVYARQCDRCLPGHWGFPSCQP-CQCNGHADDCDPVTGECLNCQDYT 890

Query: 431  GPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSC 490
              H    C    YG                PI G      G     C  PCP G      
Sbjct: 891  MGHNCERCLAGYYG---------------DPIIG-----SGDHCRPC--PCPDGP----- 923

Query: 491  NASCQCAHEAVCSPQT--GACTCTPGWHGAHCQLPCPKGQFGE-----GCASRCDCDHS- 542
            ++  Q A      P T   AC C PG+ G+ C   C  G FG      G    C C ++ 
Sbjct: 924  DSGRQFARSCYQDPVTLQLACVCDPGYIGSRCD-DCASGYFGNPSEVGGSCQPCQCHNNI 982

Query: 543  -----DGCDPVHGRC-QCQAGWMGARCHLSCPEGLWG----VNCSNTCTCKNGGT----- 587
                 + CD   GRC +C     G  C   C  G +G     +C   C C   GT     
Sbjct: 983  DTTDPEACDKETGRCLKCLYHTEGEHCQF-CRFGYYGDALQQDC-RKCVCNYLGTVQEHC 1040

Query: 588  ------CLPENGNCVCAPGFRGPSCQRSCQPGRY----GKRCVPCKC-ANHSF---CHPS 633
                  C    G C+C P   G +C R C P  +    G  C PC C A HSF   C+  
Sbjct: 1041 NGSDCQCDKATGQCLCLPNVIGQNCDR-CAPNTWQLASGTGCDPCNCNAAHSFGPSCNEF 1099

Query: 634  NGTCYCLAGWTGPDCSQPCPPGHWGE---NCAQTCQCHHGG----TCHPQDGSCICPLGW 686
             G C C+ G+ G  CS+ C    WG+    C + C C   G     C    G C+C  G 
Sbjct: 1100 TGQCQCMPGFGGRTCSE-CQELFWGDPDVEC-RACDCDPRGIETPQCDQSTGQCVCVEGV 1157

Query: 687  TGHHCLEGCPLGTFGA--NCSQPCQC 710
             G  C + C  G  G   +C+   QC
Sbjct: 1158 EGPRC-DKCTRGYSGVFPDCTPCHQC 1182



 Score =  139 bits (350), Expect = 1e-32
 Identities = 119/397 (29%), Positives = 147/397 (37%), Gaps = 95/397 (23%)

Query: 415  VCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCE-------NAIACSPIDGECV 467
            VC    G CQC P   G  C + C P T+G   S    CE       NA  C+P+ G+C 
Sbjct: 784  VCDPNGGQCQCRPNVVGRTC-NRCAPGTFGFGPSGCKPCECHLQGSVNAF-CNPVTGQCH 841

Query: 468  CKEGWQRGNCSVPCPPGTWGFSCNASCQC-AHEAVCSPQTGACT-------------CTP 513
            C +G     C   C PG WGF     CQC  H   C P TG C              C  
Sbjct: 842  CFQGVYARQCD-RCLPGHWGFPSCQPCQCNGHADDCDPVTGECLNCQDYTMGHNCERCLA 900

Query: 514  GWHGA-------HCQ-LPCPKG-----QFGEGCASRCDCDHSDGCDPVHGR--CQCQAGW 558
            G++G        HC+  PCP G     QF   C            DPV  +  C C  G+
Sbjct: 901  GYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQ----------DPVTLQLACVCDPGY 950

Query: 559  MGARCHLSCPEGLWG-----------VNCSNTCTCKNGGTCLPENGNCV-CAPGFRGPSC 606
            +G+RC   C  G +G             C N     +   C  E G C+ C     G  C
Sbjct: 951  IGSRCD-DCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHC 1009

Query: 607  QRSCQPGRYG----KRCVPCKC-----------ANHSFCHPSNGTCYCLAGWTGPDCSQP 651
            Q  C+ G YG    + C  C C            +   C  + G C CL    G +C + 
Sbjct: 1010 Q-FCRFGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCDR- 1067

Query: 652  CPPGHW----GENCAQTCQCH----HGGTCHPQDGSCICPLGWTGHHCLEGCPL--GTFG 701
            C P  W    G  C   C C+     G +C+   G C C  G+ G  C E   L  G   
Sbjct: 1068 CAPNTWQLASGTGC-DPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWGDPD 1126

Query: 702  ANCSQPCQCGPG----EKCHPETGACVCPPGHSGAPC 734
              C + C C P      +C   TG CVC  G  G  C
Sbjct: 1127 VEC-RACDCDPRGIETPQCDQSTGQCVCVEGVEGPRC 1162



 Score =  137 bits (345), Expect = 5e-32
 Identities = 123/417 (29%), Positives = 152/417 (36%), Gaps = 80/417 (19%)

Query: 276  CRCHNGG----LCDRFTGQCRCAPGYTGDRCREECP-VGRFGQDCAETCDC----APDAR 326
            C C   G    +CD   GQC+C P   G  C    P    FG    + C+C    + +A 
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFGPSGCKPCECHLQGSVNAF 832

Query: 327  CFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGEC------ 380
            C P  G C C  G    +C DR C  G +G     PC C+  H+  C P+ GEC      
Sbjct: 833  CNPVTGQCHCFQGVYARQC-DR-CLPGHWGFPSCQPCQCN-GHADDCDPVTGECLNCQDY 889

Query: 381  -------SCLPGW-------AGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCA 426
                    CL G+       +G HC      D    G Q    C    V    +  C C 
Sbjct: 890  TMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLA--CVCD 947

Query: 427  PGYTGPHCASLCP-----PDTYGVNCSARCSCENAI------ACSPIDGECV-CKEGWQR 474
            PGY G  C          P   G +C   C C N I      AC    G C+ C    + 
Sbjct: 948  PGYIGSRCDDCASGYFGNPSEVGGSCQP-CQCHNNIDTTDPEACDKETGRCLKCLYHTEG 1006

Query: 475  GNCSVPCPPGTWGFSCNASCQ---CAH-----------EAVCSPQTGACTCTPGWHGAHC 520
             +C   C  G +G +    C+   C +           +  C   TG C C P   G +C
Sbjct: 1007 EHCQF-CRFGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNC 1065

Query: 521  QLPCPKG---QFGEGC-ASRCDCDHSDG--CDPVHGRCQCQAGWMGARCHLSCPEGLWG- 573
                P       G GC    C+  HS G  C+   G+CQC  G+ G  C   C E  WG 
Sbjct: 1066 DRCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCS-ECQELFWGD 1124

Query: 574  --VNCSNTCTCKNGG----TCLPENGNCVCAPGFRGPSCQRSCQPGRYG--KRCVPC 622
              V C   C C   G     C    G CVC  G  GP C + C  G  G    C PC
Sbjct: 1125 PDVEC-RACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDK-CTRGYSGVFPDCTPC 1179



 Score =  135 bits (339), Expect = 3e-31
 Identities = 134/444 (30%), Positives = 170/444 (38%), Gaps = 106/444 (23%)

Query: 191  CQCH-----GAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQ---NGGV-- 240
            C+C       + CDP  G C C     G +C+  C+ GT GF       C+    G V  
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTCN-RCAPGTFGFGPSGCKPCECHLQGSVNA 831

Query: 241  FQTP-QGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCH-NGGLCDRFTGQC------- 291
            F  P  G C C  G     C    P  +  P+C Q C+C+ +   CD  TG+C       
Sbjct: 832  FCNPVTGQCHCFQGVYARQCDRCLPGHWGFPSC-QPCQCNGHADDCDPVTGECLNCQDYT 890

Query: 292  ------RCAPGY-------TGDRCRE-ECPVG-RFGQDCAETCDCAPDARCFPANGACLC 336
                  RC  GY       +GD CR   CP G   G+  A +C   P         AC+C
Sbjct: 891  MGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDP----VTLQLACVC 946

Query: 337  EHGFTGDRCTDRLCPDGFYGL------SCQAPCTC----DREHSLSCHPMNGEC-SCLPG 385
            + G+ G RC D  C  G++G       SCQ PC C    D     +C    G C  CL  
Sbjct: 947  DPGYIGSRCDD--CASGYFGNPSEVGGSCQ-PCQCHNNIDTTDPEACDKETGRCLKCLYH 1003

Query: 386  WAGLHC--------NESCPQDTHGPGC------QEHCLCLHGGVCQA--TSGLCQCAPGY 429
              G HC         ++  QD     C      QEHC   +G  CQ    +G C C P  
Sbjct: 1004 TEGEHCQFCRFGYYGDALQQDCRKCVCNYLGTVQEHC---NGSDCQCDKATGQCLCLPNV 1060

Query: 430  TGPHCASLCPPDTY----GVNCSARCSCENA----IACSPIDGECVCKEGWQRGNCSVPC 481
             G +C   C P+T+    G  C   C+C  A     +C+   G+C C  G+    CS  C
Sbjct: 1061 IGQNC-DRCAPNTWQLASGTGCDP-CNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCS-EC 1117

Query: 482  PPGTWG---FSCNASCQCAHEAVCSPQ----TGACTCTPGWHGAHCQLPCPKGQFGEGCA 534
                WG     C A C C    + +PQ    TG C C  G  G  C   C +G  G    
Sbjct: 1118 QELFWGDPDVECRA-CDCDPRGIETPQCDQSTGQCVCVEGVEGPRCD-KCTRGYSGV--- 1172

Query: 535  SRCDCDHSDGCDPVHGRCQCQAGW 558
                      C P H   QC A W
Sbjct: 1173 -------FPDCTPCH---QCFALW 1186



 Score =  133 bits (334), Expect = 1e-30
 Identities = 104/352 (29%), Positives = 135/352 (38%), Gaps = 78/352 (22%)

Query: 451  CSCEN----AIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFS------CNASCQCAHEA 500
            C C+     +  C P  G+C C+       C+  C PGT+GF       C    Q +  A
Sbjct: 773  CECDPQGSLSSVCDPNGGQCQCRPNVVGRTCN-RCAPGTFGFGPSGCKPCECHLQGSVNA 831

Query: 501  VCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCD-HSDGCDPVHGRC-QCQAGW 558
             C+P TG C C  G +   C   C  G +G      C C+ H+D CDPV G C  CQ   
Sbjct: 832  FCNPVTGQCHCFQGVYARQCD-RCLPGHWGFPSCQPCQCNGHADDCDPVTGECLNCQDYT 890

Query: 559  MGARCHLSCPEGLWG------VNCSNTCTCKNGGTCLPENGN----------------CV 596
            MG  C   C  G +G       +    C C +G    P++G                 CV
Sbjct: 891  MGHNCE-RCLAGYYGDPIIGSGDHCRPCPCPDG----PDSGRQFARSCYQDPVTLQLACV 945

Query: 597  CAPGFRGPSCQRSC-----QPGRYGKRCVPCKCANH------SFCHPSNGTCY-CLAGWT 644
            C PG+ G  C          P   G  C PC+C N+        C    G C  CL    
Sbjct: 946  CDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTE 1005

Query: 645  GPDCSQPCPPGHWGENCAQTCQ---CHHGGT-----------CHPQDGSCICPLGWTGHH 690
            G  C Q C  G++G+   Q C+   C++ GT           C    G C+C     G +
Sbjct: 1006 GEHC-QFCRFGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQN 1064

Query: 691  CLEGCPLGTF----GANCSQPCQCGP----GEKCHPETGACVCPPGHSGAPC 734
            C + C   T+    G  C  PC C      G  C+  TG C C PG  G  C
Sbjct: 1065 C-DRCAPNTWQLASGTGC-DPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTC 1114



 Score =  129 bits (324), Expect = 1e-29
 Identities = 114/397 (28%), Positives = 148/397 (37%), Gaps = 113/397 (28%)

Query: 143  QCDKPCSCGNNSSCDPKSGVCSC--------------------PSGLQPPNC-------- 174
            +CD   S   +S CDP  G C C                    PSG +P  C        
Sbjct: 774  ECDPQGSL--SSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFGPSGCKPCECHLQGSVNA 831

Query: 175  -------------------LQPCTPGYYG-PACQFRCQC--HGAPCDPQTGACF-CPAER 211
                                  C PG++G P+CQ  CQC  H   CDP TG C  C    
Sbjct: 832  FCNPVTGQCHCFQGVYARQCDRCLPGHWGFPSCQ-PCQCNGHADDCDPVTGECLNCQDYT 890

Query: 212  TGPSC---------DVSCSQGTSGFFCPSTHSCQNGGVFQ--------TPQGSCSCPPGW 254
             G +C         D     G     CP      +G  F         T Q +C C PG+
Sbjct: 891  MGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACVCDPGY 950

Query: 255  MGTICSLPCPEGFHG-----PNCSQECRCHNG------GLCDRFTGQC-RCAPGYTGDRC 302
            +G+ C   C  G+ G         Q C+CHN         CD+ TG+C +C     G+ C
Sbjct: 951  IGSRCD-DCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHC 1009

Query: 303  REECPVGRFG----QDCAETCDC-----------APDARCFPANGACLCEHGFTGDRCTD 347
             + C  G +G    QDC + C C             D +C  A G CLC     G  C D
Sbjct: 1010 -QFCRFGYYGDALQQDCRK-CVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNC-D 1066

Query: 348  RLCPDGFY---GLSCQAPCTCDREHSL--SCHPMNGECSCLPGWAGLHCNESCPQDTHGP 402
            R  P+ +    G  C  PC C+  HS   SC+   G+C C+PG+ G  C+E        P
Sbjct: 1067 RCAPNTWQLASGTGCD-PCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWGDP 1125

Query: 403  GCQ-EHCLCLHGGV----CQATSGLCQCAPGYTGPHC 434
              +   C C   G+    C  ++G C C  G  GP C
Sbjct: 1126 DVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRC 1162



 Score =  108 bits (269), Expect = 3e-23
 Identities = 90/303 (29%), Positives = 114/303 (37%), Gaps = 62/303 (20%)

Query: 487  GFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFG---EGCASRCDCDHSD 543
            G +C    Q +  +VC P  G C C P   G  C   C  G FG    GC   C+C H  
Sbjct: 770  GLACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCN-RCAPGTFGFGPSGC-KPCEC-HLQ 826

Query: 544  G-----CDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCK-NGGTCLPENGNCV- 596
            G     C+PV G+C C  G    +C   C  G WG      C C  +   C P  G C+ 
Sbjct: 827  GSVNAFCNPVTGQCHCFQGVYARQCD-RCLPGHWGFPSCQPCQCNGHADDCDPVTGECLN 885

Query: 597  CAPGFRGPSCQRSCQPGRY-------GKRCVPCKC-----ANHSF---CHPSNGT----C 637
            C     G +C+R C  G Y       G  C PC C     +   F   C+    T    C
Sbjct: 886  CQDYTMGHNCER-CLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLAC 944

Query: 638  YCLAGWTGPDCSQPCPPGHWGE-----NCAQTCQCHHG------GTCHPQDGSCI-CPLG 685
             C  G+ G  C   C  G++G         Q CQCH+         C  + G C+ C   
Sbjct: 945  VCDPGYIGSRCDD-CASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYH 1003

Query: 686  WTGHHCLEGCPLGTFGANCSQPC-QC-------------GPGEKCHPETGACVCPPGHSG 731
              G HC + C  G +G    Q C +C             G   +C   TG C+C P   G
Sbjct: 1004 TEGEHC-QFCRFGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIG 1062

Query: 732  APC 734
              C
Sbjct: 1063 QNC 1065



 Score =  100 bits (248), Expect = 9e-21
 Identities = 89/308 (28%), Positives = 120/308 (38%), Gaps = 80/308 (25%)

Query: 83   DHRQRLQCCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGP 142
            DH +   C  G    R F     A+ C          C C PG+ G  C  +CA G +G 
Sbjct: 912  DHCRPCPCPDGPDSGRQF-----ARSCYQDPVTLQLACVCDPGYIGSRCD-DCASGYFGN 965

Query: 143  QCD-----KPCSCGNN------SSCDPKSGVC-SCPSGLQPPNCLQPCTPGYYGPACQFR 190
              +     +PC C NN       +CD ++G C  C    +  +C Q C  GYYG A Q  
Sbjct: 966  PSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHC-QFCRFGYYGDALQQD 1024

Query: 191  CQ-------------CHGAPC--DPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSC 235
            C+             C+G+ C  D  TG C C     G +CD  C+  T           
Sbjct: 1025 CRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCD-RCAPNT----------- 1072

Query: 236  QNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAP 295
                 +Q   G+  C P      C+      F GP+C++            FTGQC+C P
Sbjct: 1073 -----WQLASGT-GCDP------CNCNAAHSF-GPSCNE------------FTGQCQCMP 1107

Query: 296  GYTGDRCREECPVGRFGQDCAE--TCDCAP----DARCFPANGACLCEHGFTGDRCTDRL 349
            G+ G  C  EC    +G    E   CDC P      +C  + G C+C  G  G RC    
Sbjct: 1108 GFGGRTC-SECQELFWGDPDVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDK-- 1164

Query: 350  CPDGFYGL 357
            C  G+ G+
Sbjct: 1165 CTRGYSGV 1172



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 79/305 (25%), Positives = 104/305 (34%), Gaps = 86/305 (28%)

Query: 148 CSC-GNNSSCDPKSGV-----------CSCPSGLQPPNCLQPCTPGYY-----------G 184
           C C G+ S C P  G            C C    +  NC + C   Y+            
Sbjct: 271 CFCYGHASECAPVDGFNEEVEGMVHGHCMCRHNTKGLNC-ELCMDFYHDLPWRPAEGRNS 329

Query: 185 PACQFRCQC--HGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQ 242
            AC+ +C C  H   C             +G  CD  C   T G  C           +Q
Sbjct: 330 NACK-KCNCNEHSISCHFDMAVYLATGNVSGGVCD-DCQHNTMGRNCEQCKPFY----YQ 383

Query: 243 TPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRC-----HNGGLCDRFT--------G 289
            P+                        PN  + C C      N G+CD +T        G
Sbjct: 384 HPE-------------------RDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAG 424

Query: 290 QCRCAPGYTGDRCREECPVGRFGQDCAE-----TCDCAPDAR------CFPANGACLCEH 338
           QCRC     G+ C + C  G +     +     +C C P         C    G C C+ 
Sbjct: 425 QCRCKLNVEGEHC-DVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKR 483

Query: 339 GFTGDRCTDRLCPDGFYGLS-----CQAPCTCDREHSL--SCHPMNGECSCLPGWAGLHC 391
             TG  C D+  P+  +GLS     C+ PC CD   +L  SC   +G+CSC P   G  C
Sbjct: 484 LVTGQHC-DQCLPE-HWGLSNDLDGCR-PCDCDLGGALNNSCFAESGQCSCRPHMIGRQC 540

Query: 392 NESCP 396
           NE  P
Sbjct: 541 NEVEP 545



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 64/253 (25%), Positives = 92/253 (36%), Gaps = 70/253 (27%)

Query: 331 NGACLCEHGFTGDRCTDRLCPDGFYGL-----------SCQAPCTCDREHSLSCH----- 374
           +G C+C H   G  C   LC D ++ L           +C+  C C+ EHS+SCH     
Sbjct: 295 HGHCMCRHNTKGLNC--ELCMDFYHDLPWRPAEGRNSNACKK-CNCN-EHSISCHFDMAV 350

Query: 375 ------PMNGECS-CLPGWAGLHCNESCP-------QDTHGPGCQEHCLC-----LHGGV 415
                    G C  C     G +C +  P       +D   P   E C C      + G+
Sbjct: 351 YLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGI 410

Query: 416 CQA--------TSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPID---- 463
           C +         +G C+C     G HC  +C    Y ++      C++  AC+P+     
Sbjct: 411 CDSYTDFSTGLIAGQCRCKLNVEGEHC-DVCKEGFYDLSSEDPFGCKSC-ACNPLGTIPG 468

Query: 464 --------GECVCKEGWQRGNCSVPCPPGTWGFSCNAS----CQC----AHEAVCSPQTG 507
                   G C CK      +C   C P  WG S +      C C    A    C  ++G
Sbjct: 469 GNPCDSETGHCYCKRLVTGQHCD-QCLPEHWGLSNDLDGCRPCDCDLGGALNNSCFAESG 527

Query: 508 ACTCTPGWHGAHC 520
            C+C P   G  C
Sbjct: 528 QCSCRPHMIGRQC 540



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 67/291 (23%), Positives = 95/291 (32%), Gaps = 81/291 (27%)

Query: 443 YGVNCSARCSCE-NAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAV 501
           Y +     C C  +A  C+P+DG     EG   G+C   C   T G +C       H+  
Sbjct: 263 YDMVVRGNCFCYGHASECAPVDGFNEEVEGMVHGHCM--CRHNTKGLNCELCMDFYHDLP 320

Query: 502 CSPQTG----AC-TCTPGWHGAHCQL-----------------PCPKGQFGEGC------ 533
             P  G    AC  C    H   C                    C     G  C      
Sbjct: 321 WRPAEGRNSNACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPF 380

Query: 534 --------------ASRCDCDHSDG-----CDP--------VHGRCQCQAGWMGARCHLS 566
                           RC CD +       CD         + G+C+C+    G  C + 
Sbjct: 381 YYQHPERDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDV- 439

Query: 567 CPEGLWGVNCSNTCTCKN-----------GGTCLPENGNCVCAPGFRGPSCQRSCQPGRY 615
           C EG + ++  +   CK+           G  C  E G+C C     G  C + C P  +
Sbjct: 440 CKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQ-CLPEHW 498

Query: 616 G-----KRCVPCKC----ANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHW 657
           G       C PC C    A ++ C   +G C C     G  C++   PG++
Sbjct: 499 GLSNDLDGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNE-VEPGYY 548



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 61/257 (23%), Positives = 84/257 (32%), Gaps = 70/257 (27%)

Query: 246 GSCSCPPGWMGTICSLPCPEGFH----------GPNCSQECRCHNGGLCDRFTGQCRCAP 295
           G C C     G  C L C + +H            N  ++C C+   +   F      A 
Sbjct: 296 GHCMCRHNTKGLNCEL-CMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLAT 354

Query: 296 GYTGDRCREECPVGRFGQDC--------------------AETCDCAP------------ 323
           G       ++C     G++C                     E C C P            
Sbjct: 355 GNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDSY 414

Query: 324 -DARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMN----- 377
            D       G C C+    G+ C   +C +GFY LS + P  C    S +C+P+      
Sbjct: 415 TDFSTGLIAGQCRCKLNVEGEHCD--VCKEGFYDLSSEDPFGCK---SCACNPLGTIPGG 469

Query: 378 -------GECSCLPGWAGLHCNESCPQ----DTHGPGCQEHCLCLHGGV----CQATSGL 422
                  G C C     G HC++  P+         GC+  C C  GG     C A SG 
Sbjct: 470 NPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDGCRP-CDCDLGGALNNSCFAESGQ 528

Query: 423 CQCAPGYTGPHCASLCP 439
           C C P   G  C  + P
Sbjct: 529 CSCRPHMIGRQCNEVEP 545



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 50/198 (25%), Positives = 65/198 (32%), Gaps = 57/198 (28%)

Query: 592 NGNCVCAPGFRGPSCQRSCQ----------PGRYGKRCVPCKCANHSF-CH--------- 631
           +G+C+C    +G +C+               GR    C  C C  HS  CH         
Sbjct: 295 HGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLAT 354

Query: 632 --PSNGTC-YCLAGWTGPDCSQPCPPGHW--------GENCAQTCQC-----HHGGTCHP 675
              S G C  C     G +C Q C P ++          N  + C C      + G C  
Sbjct: 355 GNVSGGVCDDCQHNTMGRNCEQ-CKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDS 413

Query: 676 QD--------GSCICPLGWTGHHCLEGCPLGTFGANCSQP-----CQCGP------GEKC 716
                     G C C L   G HC + C  G +  +   P     C C P      G  C
Sbjct: 414 YTDFSTGLIAGQCRCKLNVEGEHC-DVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPC 472

Query: 717 HPETGACVCPPGHSGAPC 734
             ETG C C    +G  C
Sbjct: 473 DSETGHCYCKRLVTGQHC 490



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 46/181 (25%), Positives = 65/181 (35%), Gaps = 31/181 (17%)

Query: 108 ECVHGRCVAPNQCQCVPGW--------RGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPK 159
           +C H   +  N  QC P +        R  +    C     G Q +  C    + S    
Sbjct: 364 DCQHNT-MGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTGLI 422

Query: 160 SGVCSCPSGLQPPNCLQPCTPGYYGPACQF-----RCQCH-------GAPCDPQTGACFC 207
           +G C C   ++  +C   C  G+Y  + +       C C+       G PCD +TG C+C
Sbjct: 423 AGQCRCKLNVEGEHC-DVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYC 481

Query: 208 PAERTGPSCDVSCSQ--GTSGFF--CPSTHSCQNGGVFQ----TPQGSCSCPPGWMGTIC 259
               TG  CD    +  G S     C     C  GG          G CSC P  +G  C
Sbjct: 482 KRLVTGQHCDQCLPEHWGLSNDLDGCRPC-DCDLGGALNNSCFAESGQCSCRPHMIGRQC 540

Query: 260 S 260
           +
Sbjct: 541 N 541


>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
          Length = 3144

 Score =  143 bits (360), Expect = 1e-33
 Identities = 173/761 (22%), Positives = 261/761 (34%), Gaps = 200/761 (26%)

Query: 91   CHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSC 150
            C G  ++  F    C ++  +      N   C   W   + + E         C   CSC
Sbjct: 493  CQGVIDAYFFLAANCTEDATYVNDPEDNNSSC---WFPHEGTKEI--------CANGCSC 541

Query: 151  ------------------GN---NSSCDPKSGVCS----CPSGLQPPNCLQPCTPGYYGP 185
                              GN    ++ D +   C     C   +  P C   C+  Y G 
Sbjct: 542  LSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRC--SCSLSYIGR 599

Query: 186  ACQFRCQ-CHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCP------STHSCQNG 238
             C      C G       G C   +     +C+ S  Q      C        + SC+NG
Sbjct: 600  LCVVNVDYCLGNHSISVHGLCLALSH----NCNCSGLQRYERNICEIDTEDCKSASCKNG 655

Query: 239  GVFQTPQGSC--SCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQ------ 290
                  +G     C PG+ GT C +   E    P       C NG  C    G       
Sbjct: 656  TTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHP-------CKNGATCIDQPGNYFCQCV 708

Query: 291  ----------CRCAPGYTGDRCREECPVGRFGQDCA-ETCDCAPDARCFPANGACLCEHG 339
                      C C PGY G RC ++        DC    C+     +    +  C+C   
Sbjct: 709  PPFKVVDGFSCLCNPGYVGIRCEQDI------DDCILNACEHNSTCKDLHLSYQCVCLSD 762

Query: 340  FTGDRCTDRLCPDGFYGLSCQA-PCTCDREHSLSCHPM--NGECSCLPGWAGLHCNESCP 396
            + G+ C             C+  PC    +++ +C  +  +  C C  GW G +C+E   
Sbjct: 763  WEGNFCEQE-------SNECKMNPC----KNNSTCTDLYKSYRCECTSGWTGQNCSEEIN 811

Query: 397  QDTHGPGCQEHCLCLHGGVCQATS----GLCQCAPGYTGPHCA---SLCPPDTYGVNCSA 449
            +    P       C++GG+C  ++     +C C P YTG  C    +LC  D     C  
Sbjct: 812  ECDSDP-------CMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLC--DLLHNPCRN 862

Query: 450  RCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGAC 509
              +C   +A    +  C+C+E ++  NC +      +      SCQ   +         C
Sbjct: 863  NSTC---LALVDANQHCICREEFEGKNCEIDVKDCLF-----LSCQDYGDCEDMVNNFRC 914

Query: 510  TCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGR--CQCQAGWMGARCHLSC 567
             C PG+ G+ C++   +      C+S   C ++  C  +  R  C C+  + G  C L  
Sbjct: 915  ICRPGFSGSLCEIEINE------CSSE-PCKNNGTCVDLTNRFFCNCEPEYHGPFCELD- 966

Query: 568  PEGLWGVNCSNTCTCKNGGTCL--PENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCA 625
                  VN      C +   C+   +  NC+CAPG+ G +C+ +         C+   C 
Sbjct: 967  ------VNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLD------ECLSEPCL 1014

Query: 626  NHSFCHP--SNGTCYCLAGWTGPDC--------SQPCPPGHWGE---------------- 659
            +   C    ++ TC C +G+ G  C        S PC  G   E                
Sbjct: 1015 HDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTST 1074

Query: 660  ------NCAQTCQCHHGGTCHPQDG--SCICPLGWTGHHCLEGCPLGTFGANCSQP---- 707
                  N   +  C + G C       +CICP G+TG +C +         NC++P    
Sbjct: 1075 QCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSID------NCAEPELNS 1128

Query: 708  --------CQCGPGEKCHPETGACVCPPGHSGAPCRIGIQE 740
                    C  GPG      T  C C PG SG  C I I E
Sbjct: 1129 VICLNGGICVDGPGH-----TFDCRCLPGFSGQFCEININE 1164



 Score =  118 bits (296), Expect = 3e-26
 Identities = 129/526 (24%), Positives = 180/526 (34%), Gaps = 165/526 (31%)

Query: 119  QCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDP--KSGVCSCPSGLQPPNCLQ 176
            QC C+  W G+ C  E       P       C NNS+C    KS  C C SG    NC +
Sbjct: 756  QCVCLSDWEGNFCEQESNECKMNP-------CKNNSTCTDLYKSYRCECTSGWTGQNCSE 808

Query: 177  P---------------------------CTPGYYGPACQFR---CQCHGAPCDPQTGA-- 204
                                        C P Y G  C  R   C     PC   +    
Sbjct: 809  EINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLA 868

Query: 205  -------CFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGS--CSCPPGWM 255
                   C C  E  G +C++          C    SCQ+ G  +    +  C C PG+ 
Sbjct: 869  LVDANQHCICREEFEGKNCEIDVKD------CLFL-SCQDYGDCEDMVNNFRCICRPGFS 921

Query: 256  GTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQ--CRCAPGYTGDRCREECPVGRFGQ 313
            G++C +   E      CS E  C N G C   T +  C C P Y G  C  E  V +   
Sbjct: 922  GSLCEIEINE------CSSE-PCKNNGTCVDLTNRFFCNCEPEYHGPFC--ELDVNK--- 969

Query: 314  DCAETCDCAPDARC-FPANG-ACLCEHGFTGDRCTDRL---------------------- 349
               +   C  +  C +  +G  CLC  G+TG  C   L                      
Sbjct: 970  --CKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYT 1027

Query: 350  --CPDGFYGLSCQA----------------------PCTCDRE-HSLSCHPMNGECSCLP 384
              C  GF+G  C+                       PC+CD +  S  C     +C+ +P
Sbjct: 1028 CDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIP 1087

Query: 385  GWAGLHCNES-------CPQDTHGPGCQ---EHC--------LCLHGGVCQATSGL---C 423
                  C +S       CP+   G  C+   ++C        +CL+GG+C    G    C
Sbjct: 1088 CMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDC 1147

Query: 424  QCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSP-IDG-ECVCKEGWQRGNC--SV 479
            +C PG++G  C          +N  +   C +   C   I+G  C C+ GW   +C   +
Sbjct: 1148 RCLPGFSGQFC-------EININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENEL 1200

Query: 480  PCPPGTWGFSCNASCQCAHEAVCSPQTGA-CTCTPGWHGAHCQLPC 524
             C P +          C HE     + G+ C CTPG+      L C
Sbjct: 1201 ECIPNS----------CVHELCMENEPGSTCLCTPGFMTCSIGLLC 1236



 Score =  117 bits (293), Expect = 6e-26
 Identities = 134/519 (25%), Positives = 181/519 (34%), Gaps = 128/519 (24%)

Query: 119  QCQCVPGWRGDDCSSECAPGMWGPQCDK-PCSCGN--NSSCDPKSGVCSCPSGLQPPNCL 175
            +C+C  GW G +CS E        +CD  PC  G   + S  P   VC CP         
Sbjct: 794  RCECTSGWTGQNCSEEIN------ECDSDPCMNGGLCHESTIPGQFVCLCP--------- 838

Query: 176  QPCTPGYYGPACQFR---CQCHGAPCDPQTGA---------CFCPAERTGPSCDVSCSQG 223
                P Y G  C  R   C     PC   +           C C  E  G +C++     
Sbjct: 839  ----PLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKD- 893

Query: 224  TSGFFCPSTHSCQNGGVFQTPQGS--CSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNG 281
                 C    SCQ+ G  +    +  C C PG+ G++C +   E      CS E  C N 
Sbjct: 894  -----CLFL-SCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINE------CSSE-PCKNN 940

Query: 282  GLCDRFTGQ--CRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARC-FPANGA-CLCE 337
            G C   T +  C C P Y G  C  E  V +      +   C  +  C +  +G  CLC 
Sbjct: 941  GTCVDLTNRFFCNCEPEYHGPFC--ELDVNK-----CKISPCLDEENCVYRTDGYNCLCA 993

Query: 338  HGFTGDRCT-------------DRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGEC---S 381
             G+TG  C              D +C DG    +C         H   C     +C    
Sbjct: 994  PGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTH---CETNANDCLSNP 1050

Query: 382  CLPGWAGLHCNE---SCPQDTHGPGCQ---EHCL---CLHGGVCQATSG--LCQCAPGYT 430
            CL G      NE   SC  D     C+     C    C++ G CQ ++    C C  GYT
Sbjct: 1051 CLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYT 1110

Query: 431  GPHCA----SLCPPDTYGVNCSARCSCENAIACSPIDG-----ECVCKEGWQRGNCSVPC 481
            G +C     +   P+   V C     C        +DG     +C C  G+    C +  
Sbjct: 1111 GAYCEKSIDNCAEPELNSVICLNGGIC--------VDGPGHTFDCRCLPGFSGQFCEINI 1162

Query: 482  PPGTWGFSCNASCQCAHEAVCSPQTGA--CTCTPGWHGAHC--QLPCPKGQFGEGCASRC 537
                    C++S  C H A C        C C PGW G HC  +L C        C    
Sbjct: 1163 N------ECSSS-PCLHGADCEDHINGYVCKCQPGWSGHHCENELEC----IPNSCVHEL 1211

Query: 538  DCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNC 576
              ++  G       C C  G+M     L C + +  + C
Sbjct: 1212 CMENEPG-----STCLCTPGFMTCSIGLLCGDEIRRITC 1245



 Score =  104 bits (260), Expect = 4e-22
 Identities = 176/753 (23%), Positives = 238/753 (31%), Gaps = 193/753 (25%)

Query: 119 QCQCVPGWRGDDCSS---ECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNC- 174
           +C C P + G +CS    +C P +        C  GN S+    S +C C      P C 
Sbjct: 241 ECVCHPPFTGKNCSEIIGQCQPHV--------CFHGNCSNITSNSFICECDEQFSGPFCE 292

Query: 175 --LQPCTPGYYGP--ACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCP 230
              +PC    +     C      +   C P+  +             V C  GT      
Sbjct: 293 VSAKPCVSLLFWKRGICPNSSSAYTYEC-PKGSSSQNGETDVSEFSLVPCQNGTDCIKIS 351

Query: 231 STHSCQNGGVF-----QTPQGSCSCPPGWMGTICS-------LPCPEGFHGPNCSQ---E 275
           +   C    +F     ++ Q SC   P      C          C  GF   NC +    
Sbjct: 352 NDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDH 411

Query: 276 CR-----CHNGGLCDRFTGQCR--CAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCF 328
           C+     C N   C    G+ +  C PG T + C     V    Q     C C       
Sbjct: 412 CKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQ---HLCYCGVTFHGI 468

Query: 329 -----PANGACLCEHGFT---GDRCTDRLCPDGFYGLSCQAPCTC---DREHSLSC-HPM 376
                PA    + + GF    G++C   +    F   +C    T      +++ SC  P 
Sbjct: 469 CQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPH 528

Query: 377 NGE-------CSCLP-------------GWAGLHCNESCPQDTHGPGCQEHCLCLHGGVC 416
            G        CSCL               WAG    E+   D           C H  VC
Sbjct: 529 EGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENE-------CQHEAVC 581

Query: 417 --QATSGLCQCAPGYTGPHCA---------------SLCPPDTYGVNCSARCSCENAIAC 459
             +     C C+  Y G  C                 LC   ++  NCS     E  I C
Sbjct: 582 KDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNI-C 640

Query: 460 SPIDGEC---VCKEGWQ----RGNCSVPCPPGTWGFSCN------ASCQCAHEAVCSPQT 506
                +C    CK G      RG     C PG  G  C       AS  C + A C  Q 
Sbjct: 641 EIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQP 700

Query: 507 G----------------ACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVH- 549
           G                +C C PG+ G  C+      Q  + C     C+H+  C  +H 
Sbjct: 701 GNYFCQCVPPFKVVDGFSCLCNPGYVGIRCE------QDIDDCILNA-CEHNSTCKDLHL 753

Query: 550 -GRCQCQAGWMGARCHLSCPEGLWGVNCSNTC---TCKNGGTC--LPENGNCVCAPGFRG 603
             +C C + W G  C             SN C    CKN  TC  L ++  C C  G+ G
Sbjct: 754 SYQCVCLSDWEGNFCEQE----------SNECKMNPCKNNSTCTDLYKSYRCECTSGWTG 803

Query: 604 PSCQRSCQPGRYGKRCVPCKCANHSFCHPSN--GTCYCLAGWTGPDCSQPCPPGHWGENC 661
            +C            C    C N   CH S   G   CL           CPP + G+ C
Sbjct: 804 QNCSEEI------NECDSDPCMNGGLCHESTIPGQFVCL-----------CPPLYTGQFC 846

Query: 662 AQTCQ--------CHHGGTC---HPQDGSCICPLGWTGHHC---LEGCPLGTFGANCSQP 707
            Q           C +  TC      +  CIC   + G +C   ++ C       +C   
Sbjct: 847 HQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDC----LFLSCQDY 902

Query: 708 CQCGPGEKCHPETGACVCPPGHSGAPCRIGIQE 740
             C    +       C+C PG SG+ C I I E
Sbjct: 903 GDC----EDMVNNFRCICRPGFSGSLCEIEINE 931



 Score = 93.6 bits (231), Expect = 9e-19
 Identities = 161/707 (22%), Positives = 224/707 (31%), Gaps = 156/707 (22%)

Query: 150 CGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPC----------- 198
           C  + S +  SG   C S          C P + G  CQ    C   PC           
Sbjct: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRE 233

Query: 199 --DPQTGACFCPAERTGPSCDV-------------SCSQGTSGFFCPSTHSCQNGGVFQT 243
             D Q   C C    TG +C               +CS  TS  F        +G   + 
Sbjct: 234 NWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEV 293

Query: 244 PQGSCSCPPGWMGTIC-------SLPCPEGFHGPNCSQECR------CHNGGLCDRFTG- 289
               C     W   IC       +  CP+G    N   +        C NG  C + +  
Sbjct: 294 SAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND 353

Query: 290 -QCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARC--FPANGACLCEHGFTGDRCT 346
             C C+P +T   C+         Q   E+     +A C     +  C C  GFT   C 
Sbjct: 354 VMCICSPIFTDLLCKSI-------QTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCE 406

Query: 347 DRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQE 406
             +       ++C     C        +     C+  P W  L       Q     G   
Sbjct: 407 KAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWF-LKNVYLIHQHLCYCGVTF 465

Query: 407 HCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGEC 466
           H +C   G  Q          G  G  C  +   D Y    +A C+ +      P D   
Sbjct: 466 HGICQDKGPAQFEYVWQLGFAGSEGEKCQGVI--DAY-FFLAANCTEDATYVNDPEDNNS 522

Query: 467 VC-------KEGWQRG-NCSVPCPPGTWGFSC---------------NASCQCAHEAVCS 503
            C       KE    G +C        + + C               +   +C HEAVC 
Sbjct: 523 SCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCK 582

Query: 504 PQTG--ACTCTPGWHGAHCQLP---------------CPKGQFGEGCA-------SRCDC 539
            +     C+C+  + G  C +                C        C+       + C+ 
Sbjct: 583 DEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEI 642

Query: 540 DHSD--------GCDPVHGR----CQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGT 587
           D  D        G    H R     +C  G+ G +C +   E      C++   CKNG T
Sbjct: 643 DTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDE------CASH-PCKNGAT 695

Query: 588 CLPENGN--CVCAPGFR---GPSCQRSCQPGRYGKR-------CVPCKCANHSFCHPSNG 635
           C+ + GN  C C P F+   G SC   C PG  G R       C+   C ++S C   + 
Sbjct: 696 CIDQPGNYFCQCVPPFKVVDGFSC--LCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHL 753

Query: 636 T--CYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHP--QDGSCICPLGWTGHHC 691
           +  C CL+ W G  C Q         N  +   C +  TC    +   C C  GWTG +C
Sbjct: 754 SYQCVCLSDWEGNFCEQE-------SNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNC 806

Query: 692 LEGCPLGTFGANCSQPCQCGPGEKCH----PETGACVCPPGHSGAPC 734
            E           S PC    G  CH    P    C+CPP ++G  C
Sbjct: 807 SE-----EINECDSDPCM--NGGLCHESTIPGQFVCLCPPLYTGQFC 846



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 143/631 (22%), Positives = 196/631 (31%), Gaps = 185/631 (29%)

Query: 246 GSCSCPPGWM--GTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCR 303
           G   CP G     T+    C E      CS   +C +      ++  C C P ++G  C+
Sbjct: 155 GPSPCPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYS--CHCQPPFSGKYCQ 212

Query: 304 EECPVGRFGQDCAETCDCAPDARCFPANG-------ACLCEHGFTGDRCTD-------RL 349
           E         D      C  +  C             C+C   FTG  C++        +
Sbjct: 213 E--------LDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHV 264

Query: 350 CPDGFYG-----LSCQAPCTCDREHS-LSCHPMNGECSCLPGWAGLHCNES-------CP 396
           C   F+G      S    C CD + S   C      C  L  W    C  S       CP
Sbjct: 265 C---FHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECP 321

Query: 397 QDTHGPG----CQEHCL--CLHGGVCQATSG--LCQCAPGYTGPHCASL-CPPDTYGVNC 447
           + +          E  L  C +G  C   S   +C C+P +T   C S+    +++ +  
Sbjct: 322 KGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRN 381

Query: 448 SARC-SCENAIACSPIDGECVCKEGWQRGNC----------SVPCPPGTWGFSCNASCQC 496
           +A C  CE        D  C C  G+   NC          S+ C    W F+       
Sbjct: 382 NATCKKCEK-------DYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIG---- 430

Query: 497 AHEAVCSPQTGACTCTPGW-------------------HGAHCQLPCP-----------K 526
             + VC P    CT  P W                   HG  CQ   P            
Sbjct: 431 RFKYVCIP---GCTKNPCWFLKNVYLIHQHLCYCGVTFHGI-CQDKGPAQFEYVWQLGFA 486

Query: 527 GQFGEGC----------ASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNC 576
           G  GE C          A+ C  D +   DP      C     G +             C
Sbjct: 487 GSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTK-----------EIC 535

Query: 577 SNTCTCKN---------------GGTCLPEN----------GNCVCAPGFRGPSCQRSCQ 611
           +N C+C +                G    EN             VC      P C  SC 
Sbjct: 536 ANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRC--SCS 593

Query: 612 PGRYGKRCVPCKCANHSFC---HPSNGTCYCLAGWTGPDCS-------QPCPPGHWGENC 661
               G+ CV     N  +C   H  +    CLA     +CS         C      E+C
Sbjct: 594 LSYIGRLCV----VNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEID--TEDC 647

Query: 662 AQTCQCHHGGTCHPQDGSCI--CPLGWTGHHC---LEGCPLGTF--GANC-SQP----CQ 709
            ++  C +G T     G     C  G+ G  C   ++ C       GA C  QP    CQ
Sbjct: 648 -KSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQ 706

Query: 710 CGPGEKCHPETGACVCPPGHSGAPCRIGIQE 740
           C P  K   +  +C+C PG+ G  C   I +
Sbjct: 707 CVPPFKV-VDGFSCLCNPGYVGIRCEQDIDD 736



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 28/80 (35%), Positives = 34/80 (42%), Gaps = 12/80 (15%)

Query: 619  CVPCKCANHSFCHPSNGT--CYCLAGWTGPDCSQP---CPPGHWGENCAQTCQCHHGGTC 673
            C   KC N   C  S  +  C C  GW G  C++    C P H   +      C  G TC
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPH-----HCSRGATC 2668

Query: 674  H--PQDGSCICPLGWTGHHC 691
               P   +C CPLG TG +C
Sbjct: 2669 ISLPHGYTCFCPLGTTGIYC 2688



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 32/98 (32%), Positives = 37/98 (37%), Gaps = 19/98 (19%)

Query: 600  GFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGT---CYCLAGWTGPDCSQPCPPGH 656
            G +G S    C     G  C    C N   C   NGT   C CL  W G  C+Q      
Sbjct: 2864 GAKGGSNVGDCD----GTACGYNTCRNGGEC-TVNGTTFSCRCLPDWAGNTCNQSV---- 2914

Query: 657  WGENCAQTCQCHHGGTCHPQDG---SCICPLGWTGHHC 691
               +C     C H   C P      SC+C LGW G +C
Sbjct: 2915 ---SCLNNL-CLHQSLCIPDQSFSYSCLCTLGWVGRYC 2948



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 25/74 (33%), Positives = 33/74 (44%), Gaps = 14/74 (18%)

Query: 581  TCKNGGTCLPENG---NCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNG-- 635
            TC+NGG C   NG   +C C P + G +C +S         C+   C + S C P     
Sbjct: 2883 TCRNGGEC-TVNGTTFSCRCLPDWAGNTCNQSVS-------CLNNLCLHQSLCIPDQSFS 2934

Query: 636  -TCYCLAGWTGPDC 648
             +C C  GW G  C
Sbjct: 2935 YSCLCTLGWVGRYC 2948



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 25/73 (34%), Positives = 34/73 (46%), Gaps = 13/73 (17%)

Query: 582  CKNGGTCLPENGN--CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGT--- 636
            C+N GTC+ +N N  C C   + G  CQ +         C    C N + C P +GT   
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQFA--------SCENNPCGNGATCVPKSGTDIV 2395

Query: 637  CYCLAGWTGPDCS 649
            C C  G +GP C+
Sbjct: 2396 CLCPYGRSGPLCT 2408



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 25/74 (33%), Positives = 33/74 (44%), Gaps = 11/74 (14%)

Query: 364  TCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVC---QATS 420
            TC      + +     C CLP WAG  CN+S         C  + LCLH  +C   Q+ S
Sbjct: 2883 TCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-------SCLNN-LCLHQSLCIPDQSFS 2934

Query: 421  GLCQCAPGYTGPHC 434
              C C  G+ G +C
Sbjct: 2935 YSCLCTLGWVGRYC 2948



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 30/99 (30%), Positives = 42/99 (42%), Gaps = 26/99 (26%)

Query: 84   HRQRLQCCHGFYESRGFCVPLCAQECV--HGRCVAPNQ---CQCVPGWRGDDCSSECAPG 138
            H + ++ CH         VP CA      +G C++ N+   C+C   + G  C       
Sbjct: 2327 HGKNIENCH---------VPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFA---- 2373

Query: 139  MWGPQCDKPCSCGNNSSCDPKSG---VCSCPSGLQPPNC 174
                 C+    CGN ++C PKSG   VC CP G   P C
Sbjct: 2374 ----SCENN-PCGNGATCVPKSGTDIVCLCPYGRSGPLC 2407



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 27/82 (32%), Positives = 33/82 (40%), Gaps = 8/82 (9%)

Query: 666  QCHHGGTCHPQDGS--CICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKC--HPETG 721
            +C +GGTC     S  C C  GW G  C E   + T       P  C  G  C   P   
Sbjct: 2618 KCGNGGTCIESGTSVYCNCTTGWKGSFCTE--TVSTCDPEHDPPHHCSRGATCISLPHGY 2675

Query: 722  ACVCPPGHSGAPCR--IGIQEP 741
             C CP G +G  C   + I +P
Sbjct: 2676 TCFCPLGTTGIYCEQALSISDP 2697



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 34/103 (33%), Positives = 44/103 (42%), Gaps = 22/103 (21%)

Query: 556  AGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGN---CVCAPGFRGPSCQRS--- 609
            AG    +CH S         CS    C NGGTC+ E+G    C C  G++G  C  +   
Sbjct: 2602 AGRSVGQCHAS--------PCS-LMKCGNGGTCI-ESGTSVYCNCTTGWKGSFCTETVST 2651

Query: 610  CQPGRYGKRCVPCKCANHSFCH--PSNGTCYCLAGWTGPDCSQ 650
            C P    +   P  C+  + C   P   TC+C  G TG  C Q
Sbjct: 2652 CDP----EHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQ 2690



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 28/90 (31%), Positives = 35/90 (38%), Gaps = 15/90 (16%)

Query: 265  EGFHGPNCSQECRCHNGGLC--DRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCA 322
            E  H P C+    C N G C  D     C C   Y+G  C+             E   C 
Sbjct: 2332 ENCHVPWCAHHL-CRNNGTCISDNENLFCECPRLYSGKLCQFAS---------CENNPCG 2381

Query: 323  PDARCFPANGA---CLCEHGFTGDRCTDRL 349
              A C P +G    CLC +G +G  CTD +
Sbjct: 2382 NGATCVPKSGTDIVCLCPYGRSGPLCTDAI 2411



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 23/104 (22%)

Query: 614  RYGKRCVPCK---CANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCA-QTCQ--- 666
            R+GK    C    CA+H  C  +NGTC         +    CP  + G+ C   +C+   
Sbjct: 2326 RHGKNIENCHVPWCAHH-LCR-NNGTCIS----DNENLFCECPRLYSGKLCQFASCENNP 2379

Query: 667  CHHGGTCHPQDGS---CICPLGWTGHHCLEGCPLGTFGANCSQP 707
            C +G TC P+ G+   C+CP G +G       PL T   N +QP
Sbjct: 2380 CGNGATCVPKSGTDIVCLCPYGRSG-------PLCTDAINITQP 2416



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 23/73 (31%), Positives = 32/73 (43%), Gaps = 7/73 (9%)

Query: 278  CHNGGLC--DRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACL 335
            C NGG C  +  T  CRC P + G+ C +   V      C     C PD      + +CL
Sbjct: 2884 CRNGGECTVNGTTFSCRCLPDWAGNTCNQS--VSCLNNLCLHQSLCIPDQ---SFSYSCL 2938

Query: 336  CEHGFTGDRCTDR 348
            C  G+ G  C ++
Sbjct: 2939 CTLGWVGRYCENK 2951



 Score = 38.1 bits (87), Expect = 0.043
 Identities = 27/77 (35%), Positives = 35/77 (45%), Gaps = 23/77 (29%)

Query: 150  CGNNSSC--DPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFR-CQ---C-HGAPCDPQT 202
            C NN +C  D ++  C CP               Y G  CQF  C+   C +GA C P++
Sbjct: 2344 CRNNGTCISDNENLFCECPRL-------------YSGKLCQFASCENNPCGNGATCVPKS 2390

Query: 203  GA---CFCPAERTGPSC 216
            G    C CP  R+GP C
Sbjct: 2391 GTDIVCLCPYGRSGPLC 2407



 Score = 38.1 bits (87), Expect = 0.043
 Identities = 26/85 (30%), Positives = 31/85 (36%), Gaps = 21/85 (24%)

Query: 192  QCHGAPCDPQT----GACFCPAERTGPSCDVSCSQGTSGFFCPST-----------HSCQ 236
            QCH +PC        G C      +G S   +C+ G  G FC  T           H C 
Sbjct: 2608 QCHASPCSLMKCGNGGTCI----ESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCS 2663

Query: 237  NGGV-FQTPQG-SCSCPPGWMGTIC 259
             G      P G +C CP G  G  C
Sbjct: 2664 RGATCISLPHGYTCFCPLGTTGIYC 2688



 Score = 38.1 bits (87), Expect = 0.043
 Identities = 23/73 (31%), Positives = 32/73 (43%), Gaps = 18/73 (24%)

Query: 464  GECVCKEGWQRGNCSVP-------CPPGTWGFSCNASCQCA-----HEAVCSPQTG---A 508
            G   C+ G   G C+V        C P   G +CN S  C      H+++C P      +
Sbjct: 2880 GYNTCRNG---GECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYS 2936

Query: 509  CTCTPGWHGAHCQ 521
            C CT GW G +C+
Sbjct: 2937 CLCTLGWVGRYCE 2949



 Score = 37.4 bits (85), Expect = 0.074
 Identities = 31/96 (32%), Positives = 39/96 (40%), Gaps = 15/96 (15%)

Query: 143  QCD-KPCS---CGNNSSC--DPKSGVCSCPSGLQPPNCLQP---CTPGYYGPACQFRCQC 193
            QC   PCS   CGN  +C     S  C+C +G +   C +    C P +  P     C  
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPP---HHCS- 2663

Query: 194  HGAPCD--PQTGACFCPAERTGPSCDVSCSQGTSGF 227
             GA C   P    CFCP   TG  C+ + S     F
Sbjct: 2664 RGATCISLPHGYTCFCPLGTTGIYCEQALSISDPSF 2699



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 24/84 (28%), Positives = 27/84 (32%), Gaps = 3/84 (3%)

Query: 268  HGPNCSQECRCHNGGLC--DRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDA 325
            H   CS   +C NGG C     +  C C  G+ G  C E         D    C      
Sbjct: 2610 HASPCSL-MKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATC 2668

Query: 326  RCFPANGACLCEHGFTGDRCTDRL 349
               P    C C  G TG  C   L
Sbjct: 2669 ISLPHGYTCFCPLGTTGIYCEQAL 2692



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 18/59 (30%), Positives = 24/59 (40%), Gaps = 4/59 (6%)

Query: 120  CQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCD--PKSGVCSCPSGLQPPNCLQ 176
            C C  GW+G  C+   +     P+ D P  C   ++C   P    C CP G     C Q
Sbjct: 2634 CNCTTGWKGSFCTETVS--TCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQ 2690



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 37/120 (30%), Positives = 45/120 (37%), Gaps = 35/120 (29%)

Query: 490  CNAS----CQCAHEAVC--SPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSD 543
            C+AS     +C +   C  S  +  C CT GW          KG F     S CD +H  
Sbjct: 2609 CHASPCSLMKCGNGGTCIESGTSVYCNCTTGW----------KGSFCTETVSTCDPEH-- 2656

Query: 544  GCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCL-PENGNCVCAPGFR 602
              DP H  C       GA C +S P G        TC C  G T +  E    +  P FR
Sbjct: 2657 --DPPH-HCS-----RGATC-ISLPHGY-------TCFCPLGTTGIYCEQALSISDPSFR 2700



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 20/74 (27%), Positives = 26/74 (35%), Gaps = 11/74 (14%)

Query: 493  SCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHG-- 550
            +C+   E   +  T +C C P W G  C            C +   C H   C P     
Sbjct: 2883 TCRNGGECTVNGTTFSCRCLPDWAGNTCNQ-------SVSCLNNL-CLHQSLCIPDQSFS 2934

Query: 551  -RCQCQAGWMGARC 563
              C C  GW+G  C
Sbjct: 2935 YSCLCTLGWVGRYC 2948



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 19/56 (33%), Positives = 22/56 (39%), Gaps = 13/56 (23%)

Query: 643  WTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHP-------QDGSCICPLGWTGHHC 691
            WT    S   P      +  Q   CH+GGTCH            C CPL +TG  C
Sbjct: 2090 WTSVSPSVAAP------SVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFC 2139



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 25/82 (30%), Positives = 32/82 (39%), Gaps = 21/82 (25%)

Query: 233  HSCQNGGVFQTPQG---SCSCPPGWMGTICSLPCPEGFHGPNCSQEC---RCHNGGLC-- 284
            ++C+NGG   T  G   SC C P W G  C           N S  C    C +  LC  
Sbjct: 2882 NTCRNGGEC-TVNGTTFSCRCLPDWAGNTC-----------NQSVSCLNNLCLHQSLCIP 2929

Query: 285  -DRFTGQCRCAPGYTGDRCREE 305
               F+  C C  G+ G  C  +
Sbjct: 2930 DQSFSYSCLCTLGWVGRYCENK 2951



 Score = 31.2 bits (69), Expect = 5.3
 Identities = 26/80 (32%), Positives = 33/80 (41%), Gaps = 10/80 (12%)

Query: 231  STHSCQNGGVFQTPQGS--CSCPPGWMGTIC----SLPCPEGFHGPNCSQECRCHNGGLC 284
            S   C NGG       S  C+C  GW G+ C    S   PE     +CS+   C +  L 
Sbjct: 2615 SLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCIS--LP 2672

Query: 285  DRFTGQCRCAPGYTGDRCRE 304
              +T  C C  G TG  C +
Sbjct: 2673 HGYT--CFCPLGTTGIYCEQ 2690



 Score = 30.4 bits (67), Expect = 9.0
 Identities = 18/57 (31%), Positives = 22/57 (38%), Gaps = 4/57 (7%)

Query: 380  CSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQAT--SGLCQCAPGYTGPHC 434
            C+C  GW G  C E+    T  P       C  G  C +      C C  G TG +C
Sbjct: 2634 CNCTTGWKGSFCTETV--STCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYC 2688


>gi|219842266 usherin isoform B [Homo sapiens]
          Length = 5202

 Score =  142 bits (357), Expect = 2e-33
 Identities = 153/559 (27%), Positives = 200/559 (35%), Gaps = 133/559 (23%)

Query: 190  RCQCHGAP--CDP--QTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQ 245
            RCQCHG    CD   Q   C C  E             T G  C       N   F+  Q
Sbjct: 517  RCQCHGHADNCDTTSQPYRCLCSQESF-----------TEGLHCDRCLPLYNDKPFR--Q 563

Query: 246  GSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCH---------NGGLCDRFTGQCRCAPG 296
            G        +      PC    H  +C                 GG+CD       C   
Sbjct: 564  GD------QVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDD------CEHN 611

Query: 297  YTGDRCREECPVGRFGQ--------DCAETCDCAP------DARCFPANGACLCEHGFTG 342
             TG  C E C    F Q        D  + CDC           C    G C C+   +G
Sbjct: 612  TTGRNC-ELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSG 670

Query: 343  DRCTDRLCPDGFYGLS------CQAPCTCDR----EHSLSCHPMNGECSCLPGWAGL--- 389
             +C    C +GFY L       C +PC C+     +  ++CH  +G+C C     GL   
Sbjct: 671  RQCNQ--CQNGFYNLQELDPDGC-SPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCD 727

Query: 390  HCNESCP--QDTHGPGCQEHCLC-LHGGV---CQATSGLCQCAPGYTGPHCASLCPPDTY 443
            HCN      +  +  GC E C C LHG V   C   SG C+C     G  C + C  + Y
Sbjct: 728  HCNFGFKFLRSFNDVGC-EPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDT-CRENFY 785

Query: 444  GV---NCSARCSCENA-----IACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNAS-- 493
            G+   NC A C C+ A       C+   G+C+CK   +   C+  C  G +    N S  
Sbjct: 786  GLDVTNCKA-CDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCN-KCLEGNFYLRQNNSFL 843

Query: 494  ---CQCAHEA------VCSPQTGACTCTPGWHGAHCQLPCPKGQFG------EGCASRCD 538
               C C          +C+  TG C C  G  G  C   C   ++       + C   C+
Sbjct: 844  CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCN-QCEPHRYNLTIDNFQHC-QMCE 901

Query: 539  CDHSDG-----CDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNT-----CTCKNGGT- 587
            CD         CDP+ G+C C     G RC+  C  G + ++  N      C+C   G  
Sbjct: 902  CDSLGTLPGTICDPISGQCLCVPNRQGRRCN-QCQPGFY-ISPGNATGCLPCSCHTTGAV 959

Query: 588  ---CLPENGNCVCAPG-FRGPSCQRSCQPGRYG-----KRCVPCKC----ANHSFCHPSN 634
               C    G CVC      G  C + C+   +G      RC PC C    A +  CH   
Sbjct: 960  NHICNSLTGQCVCQDASIAGQRCDQ-CKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVT 1018

Query: 635  GTCYCLAGWTGPDCSQPCP 653
            G C+C    TG  C    P
Sbjct: 1019 GQCFCKQFVTGSKCDACVP 1037



 Score =  136 bits (343), Expect = 9e-32
 Identities = 149/561 (26%), Positives = 201/561 (35%), Gaps = 145/561 (25%)

Query: 268  HGPNC---SQECRCHNGGLCDR--FTG--QC-RCAPGYTGDRCREECPVGRFGQDCAETC 319
            H  NC   SQ  RC    LC +  FT    C RC P Y     R+   V  F     + C
Sbjct: 523  HADNCDTTSQPYRC----LCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFN---CKPC 575

Query: 320  DCAPDARC---------FP------ANGACL-CEHGFTGDRCTDRLCPDGFY-------- 355
             C   ++          FP        G C  CEH  TG  C   LC D F+        
Sbjct: 576  QCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNC--ELCKDYFFRQVGADPS 633

Query: 356  GLSCQAPCTCD----REHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCL 411
             +    PC CD    R  S+ C  + G+C+C    +G  CN                   
Sbjct: 634  AIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCN------------------- 674

Query: 412  HGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEG 471
                        QC  G+   +   L P      NC+   + +  I C    G+C CK  
Sbjct: 675  ------------QCQNGFY--NLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKAN 720

Query: 472  WQRGNCSVPCPPGTWGFSCNAS--------CQC-AHEAV---CSPQTGACTCTPGWHGAH 519
                   + C    +GF    S        CQC  H +V   C+P +G C C     G  
Sbjct: 721  V----IGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQ 776

Query: 520  CQLPCPKGQFGEGCAS--RCDCDHSDG-----CDPVHGRCQCQAGWMGARCHLSCPEGLW 572
            C   C +  +G    +   CDCD +       C+   G+C C+    G +C+  C EG +
Sbjct: 777  CDT-CRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCN-KCLEGNF 834

Query: 573  GVNCSNT-----CTCKNGGT------CLPENGNCVCAPGFRGPSCQRSCQPGRYG----- 616
             +  +N+     C C   GT      C    G C C  G  G  C + C+P RY      
Sbjct: 835  YLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQ-CEPHRYNLTIDN 893

Query: 617  -KRCVPCKCAN-----HSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQT----CQ 666
             + C  C+C +      + C P +G C C+    G  C+Q C PG +      T    C 
Sbjct: 894  FQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQ-CQPGFYISPGNATGCLPCS 952

Query: 667  CHHGGT----CHPQDGSCICP-LGWTGHHCLEGCPLGTFGANCS----QPCQC----GPG 713
            CH  G     C+   G C+C      G  C + C    FG +      QPC C       
Sbjct: 953  CHTTGAVNHICNSLTGQCVCQDASIAGQRC-DQCKDHYFGFDPQTGRCQPCNCHLSGALN 1011

Query: 714  EKCHPETGACVCPPGHSGAPC 734
            E CH  TG C C    +G+ C
Sbjct: 1012 ETCHLVTGQCFCKQFVTGSKC 1032



 Score =  127 bits (320), Expect = 4e-29
 Identities = 141/547 (25%), Positives = 197/547 (36%), Gaps = 109/547 (19%)

Query: 148  CSC-GNNSSCD----PKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQT 202
            C C G+  +CD    P   +CS  S  +  +C   C P Y     +   Q +   C P  
Sbjct: 518  CQCHGHADNCDTTSQPYRCLCSQESFTEGLHC-DRCLPLYNDKPFRQGDQVYAFNCKP-- 574

Query: 203  GACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLP 262
              C C +         SC    S    P  H    GGV         C     G  C L 
Sbjct: 575  --CQCNSHSK------SCHYNISVDPFPFEHFRGGGGVCD------DCEHNTTGRNCEL- 619

Query: 263  CPEGFHGP--------NCSQECRCHNGG------LCDRFTGQCRCAPGYTGDRCREECPV 308
            C + F           +  + C C   G      LCD+  GQC C    +G +C + C  
Sbjct: 620  CKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQ-CQN 678

Query: 309  GRFGQDCAETCDCAP-----------DARCFPANGACLCEHGFTGDRCTDRLCPDGFYGL 357
            G +     +   C+P           D  C   +G C C+    G RC    C  GF  L
Sbjct: 679  GFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDH--CNFGFKFL 736

Query: 358  ------SCQAPCTCDREHSLS--CHPMNGECSCLPGWAGLHCNESCPQDTHG---PGCQE 406
                   C+ PC C+   S++  C+P +G+C C     GL C ++C ++ +G     C+ 
Sbjct: 737  RSFNDVGCE-PCQCNLHGSVNKFCNPHSGQCECKKEAKGLQC-DTCRENFYGLDVTNCKA 794

Query: 407  HCLC-----LHGGVCQATSGLCQCAPGYTGPHCASLCPPDTY----------GVNCSARC 451
             C C     L G VC A +G C C P   G  C      + Y            NC    
Sbjct: 795  -CDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTG 853

Query: 452  SCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCN-----ASCQCAH-----EAV 501
            +   ++ C+   G+C CK G     C+  C P  +  + +       C+C         +
Sbjct: 854  TINGSLLCNKSTGQCPCKLGVTGLRCN-QCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI 912

Query: 502  CSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRC-DCD-HSDG-----CDPVHGRCQC 554
            C P +G C C P   G  C    P      G A+ C  C  H+ G     C+ + G+C C
Sbjct: 913  CDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVC 972

Query: 555  Q-AGWMGARCHLSCPEGLWGVNCS----NTCTCKNGG----TCLPENGNCVCAPGFRGPS 605
            Q A   G RC   C +  +G +        C C   G    TC    G C C     G  
Sbjct: 973  QDASIAGQRCD-QCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSK 1031

Query: 606  CQRSCQP 612
            C  +C P
Sbjct: 1032 CD-ACVP 1037



 Score =  117 bits (294), Expect = 4e-26
 Identities = 129/468 (27%), Positives = 163/468 (34%), Gaps = 124/468 (26%)

Query: 146  KPCSCGN----NSS--CDPKSGVCSCPSGLQPPNCLQPCTPGYYG-----PACQFRCQCH 194
            KPC C      N S  CD   G C+C   +    C Q C  G+Y      P     C C+
Sbjct: 639  KPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQ-CQNGFYNLQELDPDGCSPCNCN 697

Query: 195  GA-------PCDPQTGACFCPAERTGPSCDVSCSQG---TSGFFCPSTHSCQ---NGGV- 240
             +        C   +G C C A   G  CD  C+ G      F       CQ   +G V 
Sbjct: 698  TSGTVDGDITCHQNSGQCKCKANVIGLRCD-HCNFGFKFLRSFNDVGCEPCQCNLHGSVN 756

Query: 241  -FQTP-QGSCSCPPGWMGTICSLPCPEGFHG---PNCSQECRCHNGG-----LCDRFTGQ 290
             F  P  G C C     G  C   C E F+G    NC + C C   G     +C+  TGQ
Sbjct: 757  KFCNPHSGQCECKKEAKGLQCD-TCRENFYGLDVTNC-KACDCDTAGSLPGTVCNAKTGQ 814

Query: 291  CRCAPGYTGDRCREECPVGRF-----------GQDCAETCDCAPDARCFPANGACLCEHG 339
            C C P   G +C  +C  G F             +C +T        C  + G C C+ G
Sbjct: 815  CICKPNVEGRQC-NKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLG 873

Query: 340  FTGDRCTDRLCPDGFYGLS------CQAPCTCDREHSLS---CHPMNGECSCLPGWAGLH 390
             TG RC    C    Y L+      CQ  C CD   +L    C P++G+C C+P   G  
Sbjct: 874  VTGLRCNQ--CEPHRYNLTIDNFQHCQM-CECDSLGTLPGTICDPISGQCLCVPNRQGRR 930

Query: 391  CNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPG-YTGPHCASLCPPDTYGVNCSA 449
            CN                               QC PG Y  P  A+ C P         
Sbjct: 931  CN-------------------------------QCQPGFYISPGNATGCLP--------- 950

Query: 450  RCSCENAIA----CSPIDGECVCKEGWQRGNCSVPCPPGTWGFS--------CNASCQCA 497
             CSC    A    C+ + G+CVC++    G     C    +GF         CN     A
Sbjct: 951  -CSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGA 1009

Query: 498  HEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGC 545
                C   TG C C     G+ C    P        AS  D ++  GC
Sbjct: 1010 LNETCHLVTGQCFCKQFVTGSKCDACVPS-------ASHLDVNNLLGC 1050



 Score =  114 bits (284), Expect = 6e-25
 Identities = 124/482 (25%), Positives = 168/482 (34%), Gaps = 115/482 (23%)

Query: 334 CLC-EHGFTGDRCTDRLCP----------DGFYGLSCQAPCTCDREHSLSCHPMNGECSC 382
           CLC +  FT     DR  P          D  Y  +C+ PC C+  HS SCH  N     
Sbjct: 536 CLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCK-PCQCN-SHSKSCH-YNISVDP 592

Query: 383 LP-----GWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASL 437
            P     G  G+ C++ C  +T G  C+         V    S +  C P          
Sbjct: 593 FPFEHFRGGGGV-CDD-CEHNTTGRNCELCKDYFFRQVGADPSAIDVCKP---------- 640

Query: 438 CPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPC-----------PPGTW 486
           C  DT G           +I C  I G+C CK       C+  C           P G  
Sbjct: 641 CDCDTVGTR-------NGSILCDQIGGQCNCKRHVSGRQCN-QCQNGFYNLQELDPDGCS 692

Query: 487 GFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKG-----QFGEGCASRCDCDH 541
             +CN S     +  C   +G C C     G  C   C  G      F +     C C+ 
Sbjct: 693 PCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCD-HCNFGFKFLRSFNDVGCEPCQCNL 751

Query: 542 SDG----CDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSN--TCTCKNGGT-----CLP 590
                  C+P  G+C+C+    G +C  +C E  +G++ +N   C C   G+     C  
Sbjct: 752 HGSVNKFCNPHSGQCECKKEAKGLQCD-TCRENFYGLDVTNCKACDCDTAGSLPGTVCNA 810

Query: 591 ENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQ 650
           + G C+C P   G  C                KC   +F    N +  CL          
Sbjct: 811 KTGQCICKPNVEGRQCN---------------KCLEGNFYLRQNNSFLCL---------- 845

Query: 651 PCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCP----LGTFGANCSQ 706
           PC       NC +T   +    C+   G C C LG TG  C +  P    L        Q
Sbjct: 846 PC-------NCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQ 898

Query: 707 PCQCG-----PGEKCHPETGACVCPPGHSGAPCRIGIQEPFTVMP-----TTPVAYNSLG 756
            C+C      PG  C P +G C+C P   G  C    Q  F + P       P + ++ G
Sbjct: 899 MCECDSLGTLPGTICDPISGQCLCVPNRQGRRCN-QCQPGFYISPGNATGCLPCSCHTTG 957

Query: 757 AV 758
           AV
Sbjct: 958 AV 959



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 84/314 (26%), Positives = 108/314 (34%), Gaps = 78/314 (24%)

Query: 494 CQC-AHEAVC--SPQTGACTCTPG--WHGAHCQLPCP---KGQFGEGC------ASRCDC 539
           CQC  H   C  + Q   C C+      G HC    P      F +G          C C
Sbjct: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577

Query: 540 D-HSDGC------DPVH--------GRCQ-CQAGWMGARCHLSCPEGLW--------GVN 575
           + HS  C      DP          G C  C+    G  C L C +  +         ++
Sbjct: 578 NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCEL-CKDYFFRQVGADPSAID 636

Query: 576 CSNTCTCKNGGT------CLPENGNCVCAPGFRGPSCQRSCQPGRYGKR------CVPCK 623
               C C   GT      C    G C C     G  C + CQ G Y  +      C PC 
Sbjct: 637 VCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQ-CQNGFYNLQELDPDGCSPCN 695

Query: 624 CANHSF------CHPSNGTCYCLAGWTGPDCSQPCPPGH-----WGENCAQTCQCH-HGG 671
           C           CH ++G C C A   G  C   C  G      + +   + CQC+ HG 
Sbjct: 696 CNTSGTVDGDITCHQNSGQCKCKANVIGLRCDH-CNFGFKFLRSFNDVGCEPCQCNLHGS 754

Query: 672 T---CHPQDGSCICPLGWTGHHCLEGCPLGTFG---ANCSQPCQCG-----PGEKCHPET 720
               C+P  G C C     G  C + C    +G    NC + C C      PG  C+ +T
Sbjct: 755 VNKFCNPHSGQCECKKEAKGLQC-DTCRENFYGLDVTNC-KACDCDTAGSLPGTVCNAKT 812

Query: 721 GACVCPPGHSGAPC 734
           G C+C P   G  C
Sbjct: 813 GQCICKPNVEGRQC 826



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 68/263 (25%), Positives = 93/263 (35%), Gaps = 80/263 (30%)

Query: 119  QCQCVPGWRGDDCSSECAPGMWGPQCDK-----PCSCGNNSS------CDPKSGVCSCPS 167
            QC C P   G  C+ +C  G +  + +      PC+C    +      C+  +G C C  
Sbjct: 814  QCICKPNVEGRQCN-KCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKL 872

Query: 168  GLQPPNCLQPCTPGYYG------PACQFRCQCH------GAPCDPQTGACFCPAERTGPS 215
            G+    C Q C P  Y         CQ  C+C       G  CDP +G C C   R G  
Sbjct: 873  GVTGLRCNQ-CEPHRYNLTIDNFQHCQM-CECDSLGTLPGTICDPISGQCLCVPNRQGRR 930

Query: 216  CDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQE 275
            C                + CQ  G + +P  +  C P                       
Sbjct: 931  C----------------NQCQ-PGFYISPGNATGCLP----------------------- 950

Query: 276  CRCHNGG----LCDRFTGQCRCA-PGYTGDRCREECPVGRFGQD----CAETCDC----A 322
            C CH  G    +C+  TGQC C      G RC ++C    FG D      + C+C    A
Sbjct: 951  CSCHTTGAVNHICNSLTGQCVCQDASIAGQRC-DQCKDHYFGFDPQTGRCQPCNCHLSGA 1009

Query: 323  PDARCFPANGACLCEHGFTGDRC 345
             +  C    G C C+   TG +C
Sbjct: 1010 LNETCHLVTGQCFCKQFVTGSKC 1032


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.140    0.516 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,169,106
Number of Sequences: 37866
Number of extensions: 4412707
Number of successful extensions: 33921
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 947
Number of HSP's that attempted gapping in prelim test: 14221
Number of HSP's gapped (non-prelim): 7689
length of query: 1037
length of database: 18,247,518
effective HSP length: 112
effective length of query: 925
effective length of database: 14,006,526
effective search space: 12956036550
effective search space used: 12956036550
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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