Search of human proteins with 27765076

Search of human proteins with 27765076

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27765076 calpain 3 isoform d [Homo sapiens]
         (309 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557405 calpain 3 isoform a [Homo sapiens]                         634   0.0  
gi|27765076 calpain 3 isoform d [Homo sapiens]                        634   0.0  
gi|47078247 calpain 3 isoform f [Homo sapiens]                        615   e-176
gi|27765072 calpain 3 isoform b [Homo sapiens]                        615   e-176
gi|27765074 calpain 3 isoform c [Homo sapiens]                        526   e-150
gi|27765080 calpain 3 isoform e [Homo sapiens]                        329   2e-90
gi|27765078 calpain 3 isoform e [Homo sapiens]                        329   2e-90
gi|12408656 calpain 1, large subunit [Homo sapiens]                   281   5e-76
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                         270   2e-72
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                         270   2e-72
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       234   6e-62
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       234   6e-62
gi|215490104 calpain 11 [Homo sapiens]                                225   4e-59
gi|4502565 calpain, small subunit 1 [Homo sapiens]                    224   6e-59
gi|51599151 calpain, small subunit 1 [Homo sapiens]                   224   6e-59
gi|221554549 calpain 8 [Homo sapiens]                                 223   2e-58
gi|14161692 calpain small subunit 2 [Homo sapiens]                    210   1e-54
gi|38707981 calpain 12 [Homo sapiens]                                 135   6e-32
gi|223468608 calpain 14 [Homo sapiens]                                126   2e-29
gi|38679884 sorcin isoform b [Homo sapiens]                           102   3e-22
gi|4507207 sorcin isoform a [Homo sapiens]                            102   3e-22
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap...    97   2e-20
gi|41152101 calpain 13 [Homo sapiens]                                  96   5e-20
gi|7019485 programmed cell death 6 [Homo sapiens]                      81   1e-15
gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]            76   4e-14
gi|37577157 calpain 5 [Homo sapiens]                                   51   1e-06
gi|223278387 calmodulin-like 5 [Homo sapiens]                          49   6e-06
gi|58218968 calmodulin 3 [Homo sapiens]                                42   5e-04
gi|4502549 calmodulin 2 [Homo sapiens]                                 42   5e-04
gi|5901912 calmodulin 1 [Homo sapiens]                                 42   5e-04

>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score =  634 bits (1634), Expect = 0.0
 Identities = 309/309 (100%), Positives = 309/309 (100%)

Query: 1   MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 60
           MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR
Sbjct: 513 MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 572

Query: 61  VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 120
           VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK
Sbjct: 573 VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 632

Query: 121 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 180
           QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF
Sbjct: 633 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 692

Query: 181 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 240
           TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN
Sbjct: 693 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 752

Query: 241 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 300
           DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL
Sbjct: 753 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 812

Query: 301 EWLQLTMYA 309
           EWLQLTMYA
Sbjct: 813 EWLQLTMYA 821


>gi|27765076 calpain 3 isoform d [Homo sapiens]
          Length = 309

 Score =  634 bits (1634), Expect = 0.0
 Identities = 309/309 (100%), Positives = 309/309 (100%)

Query: 1   MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 60
           MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR
Sbjct: 1   MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 60

Query: 61  VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 120
           VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK
Sbjct: 61  VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 120

Query: 121 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 180
           QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF
Sbjct: 121 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 180

Query: 181 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 240
           TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN
Sbjct: 181 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 240

Query: 241 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 300
           DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL
Sbjct: 241 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 300

Query: 301 EWLQLTMYA 309
           EWLQLTMYA
Sbjct: 301 EWLQLTMYA 309


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score =  615 bits (1587), Expect = e-176
 Identities = 303/309 (98%), Positives = 303/309 (98%), Gaps = 6/309 (1%)

Query: 1   MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 60
           MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR
Sbjct: 426 MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 485

Query: 61  VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 120
           VFSEKRNLSEEVENTISVDRPV      PIIFVSDRANSNKELGVDQESEEGKGKTSPDK
Sbjct: 486 VFSEKRNLSEEVENTISVDRPV------PIIFVSDRANSNKELGVDQESEEGKGKTSPDK 539

Query: 121 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 180
           QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF
Sbjct: 540 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 599

Query: 181 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 240
           TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN
Sbjct: 600 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 659

Query: 241 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 300
           DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL
Sbjct: 660 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 719

Query: 301 EWLQLTMYA 309
           EWLQLTMYA
Sbjct: 720 EWLQLTMYA 728


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score =  615 bits (1587), Expect = e-176
 Identities = 303/309 (98%), Positives = 303/309 (98%), Gaps = 6/309 (1%)

Query: 1   MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 60
           MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR
Sbjct: 513 MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 572

Query: 61  VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 120
           VFSEKRNLSEEVENTISVDRPV      PIIFVSDRANSNKELGVDQESEEGKGKTSPDK
Sbjct: 573 VFSEKRNLSEEVENTISVDRPV------PIIFVSDRANSNKELGVDQESEEGKGKTSPDK 626

Query: 121 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 180
           QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF
Sbjct: 627 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 686

Query: 181 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 240
           TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN
Sbjct: 687 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 746

Query: 241 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 300
           DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL
Sbjct: 747 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 806

Query: 301 EWLQLTMYA 309
           EWLQLTMYA
Sbjct: 807 EWLQLTMYA 815


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score =  526 bits (1355), Expect = e-150
 Identities = 265/309 (85%), Positives = 265/309 (85%), Gaps = 44/309 (14%)

Query: 1   MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 60
           MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR
Sbjct: 465 MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILR 524

Query: 61  VFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDK 120
           VFSEKRNLSEEVENTISVDRPV                                      
Sbjct: 525 VFSEKRNLSEEVENTISVDRPV-------------------------------------- 546

Query: 121 QKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 180
                 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF
Sbjct: 547 ------PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGF 600

Query: 181 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 240
           TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN
Sbjct: 601 TLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN 660

Query: 241 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 300
           DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL
Sbjct: 661 DAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL 720

Query: 301 EWLQLTMYA 309
           EWLQLTMYA
Sbjct: 721 EWLQLTMYA 729


>gi|27765080 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  329 bits (844), Expect = 2e-90
 Identities = 156/156 (100%), Positives = 156/156 (100%)

Query: 154 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 213
           MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 214 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 273
           AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 274 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 309
           FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|27765078 calpain 3 isoform e [Homo sapiens]
          Length = 156

 Score =  329 bits (844), Expect = 2e-90
 Identities = 156/156 (100%), Positives = 156/156 (100%)

Query: 154 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 213
           MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK
Sbjct: 1   MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60

Query: 214 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 273
           AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC
Sbjct: 61  AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120

Query: 274 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 309
           FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 156


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  281 bits (719), Expect = 5e-76
 Identities = 139/303 (45%), Positives = 199/303 (65%), Gaps = 47/303 (15%)

Query: 7   HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 66
           HL++DFFL NAS+ARS+ +IN+REVS RFRLPP EYV+VPST+EP++EG+F+LR FSEK 
Sbjct: 459 HLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKS 518

Query: 67  NLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQ 126
             + E+++ I  +                                      PD+Q  S  
Sbjct: 519 AGTVELDDQIQANL-------------------------------------PDEQVLS-- 539

Query: 127 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCR 186
                   E E  + F+ +F+Q+AG+DMEI   EL+ +LN +++KHKDL+T GF+LESCR
Sbjct: 540 --------EEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCR 591

Query: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246
           SM+ LMD DG+GKL L EF+ LWN+I+ +  IF+ +D D+SG++++YEMR A+  AGF L
Sbjct: 592 SMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKL 651

Query: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 306
           N +LY++I  RY++  + +DFD+F+CC VRLE MFR F   D D DG++  ++ +WLQLT
Sbjct: 652 NKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLT 711

Query: 307 MYA 309
           M+A
Sbjct: 712 MFA 714


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score =  270 bits (689), Expect = 2e-72
 Identities = 130/302 (43%), Positives = 189/302 (62%), Gaps = 43/302 (14%)

Query: 6   QHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEK 65
           +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+++PST+EPHQE +F LR+FSEK
Sbjct: 404 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 463

Query: 66  RNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSP 125
           + ++ +++  + +D P   K T P                                    
Sbjct: 464 KAITRDMDGNVDIDLPEPPKPTPP------------------------------------ 487

Query: 126 QPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESC 185
                  DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC
Sbjct: 488 -------DQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISC 540

Query: 186 RSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFH 245
           +++I+LMDT G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF 
Sbjct: 541 KNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQ 600

Query: 246 LNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQL 305
           L++ L  +I +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ L
Sbjct: 601 LSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHL 660

Query: 306 TM 307
           TM
Sbjct: 661 TM 662


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score =  270 bits (689), Expect = 2e-72
 Identities = 130/302 (43%), Positives = 189/302 (62%), Gaps = 43/302 (14%)

Query: 6   QHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEK 65
           +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+++PST+EPHQE +F LR+FSEK
Sbjct: 430 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 489

Query: 66  RNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSP 125
           + ++ +++  + +D P   K T P                                    
Sbjct: 490 KAITRDMDGNVDIDLPEPPKPTPP------------------------------------ 513

Query: 126 QPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESC 185
                  DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K    +L SC
Sbjct: 514 -------DQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISC 566

Query: 186 RSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFH 245
           +++I+LMDT G+GKL   EF   W+K+K W  +F  +D D+SGT+++YE+R A+  AGF 
Sbjct: 567 KNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQ 626

Query: 246 LNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQL 305
           L++ L  +I +RYAD+ + +DFD F+ C VRLE   R F A        I LN+ E++ L
Sbjct: 627 LSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHL 686

Query: 306 TM 307
           TM
Sbjct: 687 TM 688


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  234 bits (598), Expect = 6e-62
 Identities = 118/297 (39%), Positives = 181/297 (60%), Gaps = 48/297 (16%)

Query: 7   HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 66
           HL K+FFL N ++ RS T+IN+REV  RF+LPP EY++VPST+EP+++G+F +RVFSEK+
Sbjct: 447 HLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKK 506

Query: 67  NLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQ 126
              + V++ I  +                     +E  +                     
Sbjct: 507 ADYQAVDDEIEANL--------------------EEFDIS-------------------- 526

Query: 127 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCR 186
                   E +    FR +F Q+AG+D EI A EL+ +L  V+ K +D+K+ GF++E+C+
Sbjct: 527 --------EDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCK 578

Query: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246
            M+ ++D+DGSGKL L+EF+ LW KI+ +QKI++  D D+SGT+NSYEMR A+ +AGF +
Sbjct: 579 IMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKM 638

Query: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 303
             QL+ +I  R+AD  + IDFD+F+ C VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 639 PCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 695


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  234 bits (598), Expect = 6e-62
 Identities = 118/297 (39%), Positives = 181/297 (60%), Gaps = 48/297 (16%)

Query: 7   HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 66
           HL K+FFL N ++ RS T+IN+REV  RF+LPP EY++VPST+EP+++G+F +RVFSEK+
Sbjct: 369 HLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKK 428

Query: 67  NLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQ 126
              + V++ I  +                     +E  +                     
Sbjct: 429 ADYQAVDDEIEANL--------------------EEFDIS-------------------- 448

Query: 127 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCR 186
                   E +    FR +F Q+AG+D EI A EL+ +L  V+ K +D+K+ GF++E+C+
Sbjct: 449 --------EDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCK 500

Query: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246
            M+ ++D+DGSGKL L+EF+ LW KI+ +QKI++  D D+SGT+NSYEMR A+ +AGF +
Sbjct: 501 IMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKM 560

Query: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 303
             QL+ +I  R+AD  + IDFD+F+ C VRLE +F+ F   D +  G I+L+++ WL
Sbjct: 561 PCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWL 617


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  225 bits (573), Expect = 4e-59
 Identities = 123/302 (40%), Positives = 170/302 (56%), Gaps = 47/302 (15%)

Query: 7   HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 66
           HL+K+FF        S+ + N REVS + RLPP EY+I+PST+EPH++ +F+LRVF+EK 
Sbjct: 484 HLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKH 543

Query: 67  NLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQ 126
           + S E+                      D  N  ++L  ++ SE+               
Sbjct: 544 SESWEL----------------------DEVNYAEQLQEEKVSED--------------- 566

Query: 127 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCR 186
                     +  Q F ++FK +AG+  EI   EL+++LN +  K K  KT GF L++CR
Sbjct: 567 ----------DMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACR 616

Query: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246
            MI LMD DGSGKL L EF  LW K+K W  IF+  D D SGT+NSYEMR  +  AG  L
Sbjct: 617 CMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKL 676

Query: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 306
           NN++  ++  RYAD  + IDFDSFI CF+RL+ MF  F   D    G I L++ +WLQ+T
Sbjct: 677 NNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMT 736

Query: 307 MY 308
           M+
Sbjct: 737 MW 738


>gi|4502565 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  224 bits (572), Expect = 6e-59
 Identities = 106/192 (55%), Positives = 140/192 (72%), Gaps = 6/192 (3%)

Query: 124 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 177
           +P+P P  +        ESEE +QFR +F Q+AGDDME+ A EL  +LN VV +H DLKT
Sbjct: 77  NPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKT 136

Query: 178 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 237
            GF +++CRSM+A+MD+D +GKL  +EF +LWN IK WQ I+K +DTD+SGTI S E+  
Sbjct: 137 DGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPG 196

Query: 238 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 297
           A   AGFHLN  LY++I  RY+D+  N+DFD+FI C VRL+ MFRAF + DKDG G I++
Sbjct: 197 AFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQV 256

Query: 298 NVLEWLQLTMYA 309
           N+ EWLQLTMY+
Sbjct: 257 NIQEWLQLTMYS 268


>gi|51599151 calpain, small subunit 1 [Homo sapiens]
          Length = 268

 Score =  224 bits (572), Expect = 6e-59
 Identities = 106/192 (55%), Positives = 140/192 (72%), Gaps = 6/192 (3%)

Query: 124 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 177
           +P+P P  +        ESEE +QFR +F Q+AGDDME+ A EL  +LN VV +H DLKT
Sbjct: 77  NPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKT 136

Query: 178 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 237
            GF +++CRSM+A+MD+D +GKL  +EF +LWN IK WQ I+K +DTD+SGTI S E+  
Sbjct: 137 DGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPG 196

Query: 238 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 297
           A   AGFHLN  LY++I  RY+D+  N+DFD+FI C VRL+ MFRAF + DKDG G I++
Sbjct: 197 AFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQV 256

Query: 298 NVLEWLQLTMYA 309
           N+ EWLQLTMY+
Sbjct: 257 NIQEWLQLTMYS 268


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  223 bits (567), Expect = 2e-58
 Identities = 117/297 (39%), Positives = 174/297 (58%), Gaps = 47/297 (15%)

Query: 7   HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKR 66
           HL +DFFL     AR+ TY+N+REVS R RLPP EY++VPST+EP ++GEF LRVFSEK+
Sbjct: 449 HLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKK 508

Query: 67  NLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQ 126
             + E+ + ++ +                                              +
Sbjct: 509 AQALEIGDVVAGN--------------------------------------------PYE 524

Query: 127 PQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCR 186
           P P   DQE +   QFR +F+++AG D EI A+ LK +LN   +K  D+K  GF + +CR
Sbjct: 525 PHPSEVDQEDD---QFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCR 581

Query: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246
            MI+L+D++G+G L   EF  LW KI+ + +I+   D + SGTI+++EMR A+  AGF L
Sbjct: 582 EMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTL 641

Query: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 303
           N+Q+   I +RYA   + I+FDSF+ C +RLE +F+ F   D+D DG+++L++ EWL
Sbjct: 642 NSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698


>gi|14161692 calpain small subunit 2 [Homo sapiens]
          Length = 248

 Score =  210 bits (534), Expect = 1e-54
 Identities = 96/192 (50%), Positives = 140/192 (72%), Gaps = 6/192 (3%)

Query: 124 SPQPQPGSSD------QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKT 177
           +P+P P           ESEE ++FR  F Q+AG DME+ A +L  +LN V++KHKDLKT
Sbjct: 57  TPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKT 116

Query: 178 HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRN 237
            GF+L++CRS++++MD+D +GKL  +EF +LWN IK WQ ++K YD D SG++ S ++R 
Sbjct: 117 DGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRG 176

Query: 238 AVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 297
           A+  AGF LN QLY +I  RYA++  ++DF++FI C VRL+ MFRAF + D+D DG+I++
Sbjct: 177 ALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQV 236

Query: 298 NVLEWLQLTMYA 309
           ++ EWLQLTMY+
Sbjct: 237 SIKEWLQLTMYS 248


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  135 bits (339), Expect = 6e-32
 Identities = 86/284 (30%), Positives = 138/284 (48%), Gaps = 54/284 (19%)

Query: 29  REVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTK 88
           R+V++R  L P  Y++VPST     E +F LRVFSE+R+ + E+++ IS D    +    
Sbjct: 487 RDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYL 546

Query: 89  PIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQ 148
           P+           ELG++Q                                     +F++
Sbjct: 547 PL-----------ELGLEQ-------------------------------------LFQE 558

Query: 149 IAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESC--RSMIALMDTDGSGK-LNLQEF 205
           +AG++ E+ A +L+ +L+  +   +  + H  T      R+   L+   G G+ L L  F
Sbjct: 559 LAGEEEELNASQLQALLSIAL---EPARAHTSTPREIGLRTCEQLLQCFGHGQSLALHHF 615

Query: 206 HHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNI 265
             LW  +  WQ IF  +D D SGT+NSYE+R A+N AGFHLNNQL   +T RY D  + +
Sbjct: 616 QQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRV 675

Query: 266 DFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA 309
           DF+ F+ C   L  +F         G+G+I L   +W+++  ++
Sbjct: 676 DFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS 719


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  126 bits (317), Expect = 2e-29
 Identities = 86/308 (27%), Positives = 145/308 (47%), Gaps = 54/308 (17%)

Query: 2   HGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRV 61
           H +++ L  +FF  N   ++   ++  +EVSQ   L P  Y+IVP   E HQ+ EF+LRV
Sbjct: 431 HDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRV 490

Query: 62  FSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQ 121
           FS K    E   N+              ++F       +KE+                  
Sbjct: 491 FSRKHIFYEIGSNS-------------GVVF-------SKEI------------------ 512

Query: 122 KQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFT 181
                      DQ   + + F   F++      EI A +L+ +LN +       +   F+
Sbjct: 513 ----------EDQNERQDEFFTKFFEK----HPEINAVQLQNLLNQMTWSSLGSRQPFFS 558

Query: 182 LESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVND 241
           LE+C+ ++AL+D + SG +++QEF  LW ++K  QK+F   D   SG +N  ++  A+ +
Sbjct: 559 LEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGYLNWEQLHAAMRE 617

Query: 242 AGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLE 301
           AG  L++ +  ++ +RY    + +DF SFI   +R+E M   F    +DG GI  L   E
Sbjct: 618 AGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNLTQDGKGIY-LQKPE 676

Query: 302 WLQLTMYA 309
           W+ + +Y+
Sbjct: 677 WMMMALYS 684


>gi|38679884 sorcin isoform b [Homo sapiens]
          Length = 183

 Score =  102 bits (255), Expect = 3e-22
 Identities = 57/181 (31%), Positives = 93/181 (51%), Gaps = 8/181 (4%)

Query: 129 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCR 186
           PG      + Q      F  +AG D +I ADEL++ L    +   +K      F LE+CR
Sbjct: 7   PGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCR 61

Query: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246
            M++++D D SG +   EF  LW  +  W++ F  +DTD+SGT++  E++ A+   GF L
Sbjct: 62  LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRL 121

Query: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 306
           + Q  + I  RY+  +  I FD +I C V+L  +  +F   D    G++     +++Q  
Sbjct: 122 SPQAVNSIAKRYS-TNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCV 180

Query: 307 M 307
           M
Sbjct: 181 M 181


>gi|4507207 sorcin isoform a [Homo sapiens]
          Length = 198

 Score =  102 bits (255), Expect = 3e-22
 Identities = 57/181 (31%), Positives = 93/181 (51%), Gaps = 8/181 (4%)

Query: 129 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCR 186
           PG      + Q      F  +AG D +I ADEL++ L    +   +K      F LE+CR
Sbjct: 22  PGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKP-----FNLETCR 76

Query: 187 SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHL 246
            M++++D D SG +   EF  LW  +  W++ F  +DTD+SGT++  E++ A+   GF L
Sbjct: 77  LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRL 136

Query: 247 NNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLT 306
           + Q  + I  RY+  +  I FD +I C V+L  +  +F   D    G++     +++Q  
Sbjct: 137 SPQAVNSIAKRYS-TNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCV 195

Query: 307 M 307
           M
Sbjct: 196 M 196


>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
           sapiens]
          Length = 217

 Score = 96.7 bits (239), Expect = 2e-20
 Identities = 59/179 (32%), Positives = 88/179 (49%), Gaps = 4/179 (2%)

Query: 129 PGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSM 188
           P  SD  S         F  +AG D E+ A+EL++ L        +     F+LE+CR M
Sbjct: 41  PAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLT---QSGINGTYSPFSLETCRIM 97

Query: 189 IALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNN 248
           IA++D D +GK+    F  LW  + AW++ F   D D SGT+  +E+R A+   G+ L+ 
Sbjct: 98  IAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSP 157

Query: 249 QLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 307
           Q    I  RY+ K+  I FD ++ C V+L  +   F   D    G       ++LQ TM
Sbjct: 158 QTLTTIVKRYS-KNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTM 215


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score = 95.5 bits (236), Expect = 5e-20
 Identities = 56/185 (30%), Positives = 100/185 (54%), Gaps = 16/185 (8%)

Query: 130 GSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNT--VVNKHKDLKTHGFTLESCRS 187
           GS  +   +Q    +IF + A   ++I A +L+ +LN   +     D+    F+L+ CRS
Sbjct: 494 GSPSEHGSQQ----SIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDM----FSLDECRS 545

Query: 188 MIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDA----G 243
           ++ALM+   +G+L+ +EF  LW ++  +Q +F+   T   G + S ++  A+ +     G
Sbjct: 546 LVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQTSP-GVLLSSDLWKAIENTDFLRG 604

Query: 244 FHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWL 303
             ++ +L  ++T+RY+D    + F S +C  +RLE M + F    KDG G+  L  +EW+
Sbjct: 605 IFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTFRNLSKDGKGLY-LTEMEWM 663

Query: 304 QLTMY 308
            L MY
Sbjct: 664 SLVMY 668


>gi|7019485 programmed cell death 6 [Homo sapiens]
          Length = 191

 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 51/187 (27%), Positives = 94/187 (50%), Gaps = 10/187 (5%)

Query: 122 KQSPQPQPGSSDQESEEQQQFR-NIFKQIAGDDMEICAD-ELKKVLNTVVNKHKDLKTHG 179
           +  P   PG +   +   Q F  N+F+++  D   + +D EL++ L+             
Sbjct: 7   RPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGT-------WTP 59

Query: 180 FTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAV 239
           F   + RS+I++ D +    +N  EF  +W  I  WQ +F+ YD D SG I+  E++ A+
Sbjct: 60  FNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQAL 119

Query: 240 NDAGFHLNNQLYDIITMRY-ADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLN 298
           +  G+ L++Q +DI+  ++       I FD FI   + L+ +   F  +D D DG I+++
Sbjct: 120 SGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVS 179

Query: 299 VLEWLQL 305
             ++L +
Sbjct: 180 YEQYLSM 186


>gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]
          Length = 284

 Score = 75.9 bits (185), Expect = 4e-14
 Identities = 39/129 (30%), Positives = 72/129 (55%), Gaps = 2/129 (1%)

Query: 180 FTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAV 239
           F  E+C  MI + D   SG++++  F  LW  I+ W+ +F+ YD D+SG+I+  E++ A+
Sbjct: 151 FNDETCLMMINMFDKTKSGRIDVYGFSALWKFIQQWKNLFQQYDRDRSGSISYTELQQAL 210

Query: 240 NDAGFHLNNQLYDIITMRYADKHMN--IDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKL 297
           +  G++L+ Q   ++  RY  +  N  +  D FI    +L+ +  AF   D    G I+L
Sbjct: 211 SQMGYNLSPQFTQLLVSRYCPRSANPAMQLDRFIQVCTQLQVLTEAFREKDTAVQGNIRL 270

Query: 298 NVLEWLQLT 306
           +  +++ +T
Sbjct: 271 SFEDFVTMT 279


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 24/46 (52%), Positives = 30/46 (65%)

Query: 19  KARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSE 64
           KA S  YIN R V  R   P   YVI+P+T+EP   GEF+LRVF++
Sbjct: 445 KAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTD 490


>gi|223278387 calmodulin-like 5 [Homo sapiens]
          Length = 146

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 33/91 (36%), Positives = 50/91 (54%), Gaps = 5/91 (5%)

Query: 215 WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNN-QLYDIITMRYADKHMNIDFDSFICC 273
           ++K F   DTD +GTIN+ E+  A+   G +L+  QL  +I+   +D    I F  F+  
Sbjct: 13  YKKAFSAVDTDGNGTINAQELGAALKATGKNLSEAQLRKLISEVDSDGDGEISFQEFLTA 72

Query: 274 FVR----LEGMFRAFHAFDKDGDGIIKLNVL 300
             +    LE +  AF AFD+DGDG I ++ L
Sbjct: 73  AKKARAGLEDLQVAFRAFDQDGDGHITVDEL 103



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 36/140 (25%), Positives = 62/140 (44%), Gaps = 14/140 (10%)

Query: 137 EEQQQFRNIFKQIAGD-DMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTD 195
           EE+ Q++  F  +  D +  I A EL   L        + +         R +I+ +D+D
Sbjct: 8   EEEAQYKKAFSAVDTDGNGTINAQELGAALKATGKNLSEAQL--------RKLISEVDSD 59

Query: 196 GSGKLNLQEFHHLWNKIKA----WQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLY 251
           G G+++ QEF     K +A     Q  F+ +D D  G I   E+R A+   G  L  +  
Sbjct: 60  GDGEISFQEFLTAAKKARAGLEDLQVAFRAFDQDGDGHITVDELRRAMAGLGQPLPQEEL 119

Query: 252 D-IITMRYADKHMNIDFDSF 270
           D +I     D+   ++++ F
Sbjct: 120 DAMIREADVDQDGRVNYEEF 139


>gi|58218968 calmodulin 3 [Homo sapiens]
          Length = 149

 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 8/93 (8%)

Query: 211 KIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNN-QLYDIITMRYADKHMNIDFDS 269
           +I  +++ F  +D D  GTI + E+   +   G +    +L D+I    AD +  IDF  
Sbjct: 9   QIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPE 68

Query: 270 FICCFVRL-------EGMFRAFHAFDKDGDGII 295
           F+    R        E +  AF  FDKDG+G I
Sbjct: 69  FLTMMARKMKDTDSEEEIREAFRVFDKDGNGYI 101



 Score = 35.8 bits (81), Expect = 0.049
 Identities = 36/150 (24%), Positives = 71/150 (47%), Gaps = 18/150 (12%)

Query: 132 SDQESEEQ-QQFRNIFKQIAGD-DMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMI 189
           +DQ +EEQ  +F+  F     D D  I   EL  V+ ++     + +         + MI
Sbjct: 2   ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAEL--------QDMI 53

Query: 190 ALMDTDGSGKLNLQEFHHLW-NKIKAW------QKIFKHYDTDQSGTINSYEMRNAVNDA 242
             +D DG+G ++  EF  +   K+K        ++ F+ +D D +G I++ E+R+ + + 
Sbjct: 54  NEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNL 113

Query: 243 GFHLNNQLYD-IITMRYADKHMNIDFDSFI 271
           G  L ++  D +I     D    ++++ F+
Sbjct: 114 GEKLTDEEVDEMIREADIDGDGQVNYEEFV 143


>gi|4502549 calmodulin 2 [Homo sapiens]
          Length = 149

 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 8/93 (8%)

Query: 211 KIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNN-QLYDIITMRYADKHMNIDFDS 269
           +I  +++ F  +D D  GTI + E+   +   G +    +L D+I    AD +  IDF  
Sbjct: 9   QIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPE 68

Query: 270 FICCFVRL-------EGMFRAFHAFDKDGDGII 295
           F+    R        E +  AF  FDKDG+G I
Sbjct: 69  FLTMMARKMKDTDSEEEIREAFRVFDKDGNGYI 101



 Score = 35.8 bits (81), Expect = 0.049
 Identities = 36/150 (24%), Positives = 71/150 (47%), Gaps = 18/150 (12%)

Query: 132 SDQESEEQ-QQFRNIFKQIAGD-DMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMI 189
           +DQ +EEQ  +F+  F     D D  I   EL  V+ ++     + +         + MI
Sbjct: 2   ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAEL--------QDMI 53

Query: 190 ALMDTDGSGKLNLQEFHHLW-NKIKAW------QKIFKHYDTDQSGTINSYEMRNAVNDA 242
             +D DG+G ++  EF  +   K+K        ++ F+ +D D +G I++ E+R+ + + 
Sbjct: 54  NEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNL 113

Query: 243 GFHLNNQLYD-IITMRYADKHMNIDFDSFI 271
           G  L ++  D +I     D    ++++ F+
Sbjct: 114 GEKLTDEEVDEMIREADIDGDGQVNYEEFV 143


>gi|5901912 calmodulin 1 [Homo sapiens]
          Length = 149

 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 8/93 (8%)

Query: 211 KIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNN-QLYDIITMRYADKHMNIDFDS 269
           +I  +++ F  +D D  GTI + E+   +   G +    +L D+I    AD +  IDF  
Sbjct: 9   QIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPE 68

Query: 270 FICCFVRL-------EGMFRAFHAFDKDGDGII 295
           F+    R        E +  AF  FDKDG+G I
Sbjct: 69  FLTMMARKMKDTDSEEEIREAFRVFDKDGNGYI 101



 Score = 35.8 bits (81), Expect = 0.049
 Identities = 36/150 (24%), Positives = 71/150 (47%), Gaps = 18/150 (12%)

Query: 132 SDQESEEQ-QQFRNIFKQIAGD-DMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMI 189
           +DQ +EEQ  +F+  F     D D  I   EL  V+ ++     + +         + MI
Sbjct: 2   ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAEL--------QDMI 53

Query: 190 ALMDTDGSGKLNLQEFHHLW-NKIKAW------QKIFKHYDTDQSGTINSYEMRNAVNDA 242
             +D DG+G ++  EF  +   K+K        ++ F+ +D D +G I++ E+R+ + + 
Sbjct: 54  NEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNL 113

Query: 243 GFHLNNQLYD-IITMRYADKHMNIDFDSFI 271
           G  L ++  D +I     D    ++++ F+
Sbjct: 114 GEKLTDEEVDEMIREADIDGDGQVNYEEFV 143


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,992,186
Number of Sequences: 37866
Number of extensions: 548695
Number of successful extensions: 4081
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 161
Number of HSP's that attempted gapping in prelim test: 3668
Number of HSP's gapped (non-prelim): 506
length of query: 309
length of database: 18,247,518
effective HSP length: 102
effective length of query: 207
effective length of database: 14,385,186
effective search space: 2977733502
effective search space used: 2977733502
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.