Search of human proteins with 116292174

Search of human proteins with 116292174

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116292174 fidgetin-like 2 [Homo sapiens]
         (653 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116292174 fidgetin-like 2 [Homo sapiens]                          1353   0.0  
gi|64084766 fidgetin [Homo sapiens]                                   455   e-128
gi|31742536 fidgetin-like 1 [Homo sapiens]                            244   2e-64
gi|112789543 fidgetin-like 1 [Homo sapiens]                           244   2e-64
gi|40806170 spastin isoform 2 [Homo sapiens]                          180   4e-45
gi|11875211 spastin isoform 1 [Homo sapiens]                          180   4e-45
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     132   1e-30
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               132   1e-30
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               132   1e-30
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]         127   4e-29
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]          124   4e-28
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]              114   3e-25
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              113   5e-25
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     107   3e-23
gi|6005942 valosin-containing protein [Homo sapiens]                  103   7e-22
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]    96   8e-20
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]             96   1e-19
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]              95   2e-19
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]        95   2e-19
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]      94   5e-19
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]             94   5e-19
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                  91   3e-18
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                  91   3e-18
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]             91   4e-18
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]            91   4e-18
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]            87   5e-17
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                       85   2e-16
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                        85   2e-16
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...    81   3e-15
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...    81   3e-15

>gi|116292174 fidgetin-like 2 [Homo sapiens]
          Length = 653

 Score = 1353 bits (3503), Expect = 0.0
 Identities = 653/653 (100%), Positives = 653/653 (100%)

Query: 1   MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCHYAWAHDDISALTASNLL 60
           MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCHYAWAHDDISALTASNLL
Sbjct: 1   MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCHYAWAHDDISALTASNLL 60

Query: 61  KRYAEKYSGVLDSPYERPALGGYSDASFLNGAKGDPEPWPGPEPPYPLASLHEGLPGTKS 120
           KRYAEKYSGVLDSPYERPALGGYSDASFLNGAKGDPEPWPGPEPPYPLASLHEGLPGTKS
Sbjct: 61  KRYAEKYSGVLDSPYERPALGGYSDASFLNGAKGDPEPWPGPEPPYPLASLHEGLPGTKS 120

Query: 121 GGGGGSGALGGSPVLAGNLPEPLYAGNACGGPSAAPEYAAGYGGGYLAPGYCAQTGAALP 180
           GGGGGSGALGGSPVLAGNLPEPLYAGNACGGPSAAPEYAAGYGGGYLAPGYCAQTGAALP
Sbjct: 121 GGGGGSGALGGSPVLAGNLPEPLYAGNACGGPSAAPEYAAGYGGGYLAPGYCAQTGAALP 180

Query: 181 PPPPAALLQPPPPPGYGPSAPLYNYPAGGYAAQPGYGALPPPPGPPPAPYLTPGLPAPTP 240
           PPPPAALLQPPPPPGYGPSAPLYNYPAGGYAAQPGYGALPPPPGPPPAPYLTPGLPAPTP
Sbjct: 181 PPPPAALLQPPPPPGYGPSAPLYNYPAGGYAAQPGYGALPPPPGPPPAPYLTPGLPAPTP 240

Query: 241 LPAPAPPTAYGFPTAAPGAESGLSLKRKAADEGPEGRYRKYAYEPAKAPVADGASYPAAD 300
           LPAPAPPTAYGFPTAAPGAESGLSLKRKAADEGPEGRYRKYAYEPAKAPVADGASYPAAD
Sbjct: 241 LPAPAPPTAYGFPTAAPGAESGLSLKRKAADEGPEGRYRKYAYEPAKAPVADGASYPAAD 300

Query: 301 NGECRGNGFRAKPPGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGFA 360
           NGECRGNGFRAKPPGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGFA
Sbjct: 301 NGECRGNGFRAKPPGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGFA 360

Query: 361 VPSGETPKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG 420
           VPSGETPKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG
Sbjct: 361 VPSGETPKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG 420

Query: 421 SLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAA 480
           SLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAA
Sbjct: 421 SLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAA 480

Query: 481 RCRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAA 540
           RCRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAA
Sbjct: 481 RCRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAA 540

Query: 541 LDEATRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQ 600
           LDEATRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQ
Sbjct: 541 LDEATRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQ 600

Query: 601 LCQQAAAGAGLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYGSGH 653
           LCQQAAAGAGLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYGSGH
Sbjct: 601 LCQQAAAGAGLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYGSGH 653


>gi|64084766 fidgetin [Homo sapiens]
          Length = 759

 Score =  455 bits (1171), Expect = e-128
 Identities = 288/751 (38%), Positives = 396/751 (52%), Gaps = 107/751 (14%)

Query: 1   MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCH-YAWAHDDISALTASNL 59
           M WTPEHAQ    WPEQH D++STT SPAHK+E   G  QR + YAWA+DDISALTASNL
Sbjct: 12  MQWTPEHAQ----WPEQHFDITSTTRSPAHKVEAYRGHLQRTYQYAWANDDISALTASNL 67

Query: 60  LKRYAEKYSGVLDSPYERPALGGYSD--ASFLNGAKGDPEPWP---GPEPPYPLASLHEG 114
           LK+YAEKYSG+L+ P +RP L  YSD  +  +NG K + EPW      E  YP+  + + 
Sbjct: 68  LKKYAEKYSGILEGPVDRPVLSNYSDTPSGLVNGRKNESEPWQPSLNSEAVYPMNCVPDV 127

Query: 115 LPGTKSGGGGG------SGALGGSPVLAGNLPEPLYAGNACGGPSA--------APEYAA 160
           +  +K+G          S ++G SP +A NL EP Y+ + CG  +         + EYA 
Sbjct: 128 ITASKAGVSSALPPADVSASIGSSPGVASNLTEPSYSSSTCGSHTVPSLHAGLPSQEYAP 187

Query: 161 GYGGGYLAPGYCAQTGAALPPPPPA-----ALLQPPPPP--------GYGPSAPL--YNY 205
           GY G YL   Y +Q   ALP P P+      LLQPPPPP        GY  ++ L  Y+Y
Sbjct: 188 GYNGSYLHSTYSSQPAPALPSPHPSPLHSSGLLQPPPPPPPPPALVPGYNGTSNLSSYSY 247

Query: 206 PAGGYAAQPGYGALPPPPG--PPPAPYLTPGLPAPTPLPAPAPP----TAYGFPTAAPGA 259
           P+  Y  Q   G+   P G  PPP+ YL  G+PAPTPLP    P      +G    AP A
Sbjct: 248 PSASYPPQTAVGSGYSPGGAPPPPSAYLPSGIPAPTPLPPTTVPGYTYQGHGLTPIAPSA 307

Query: 260 ---ESGLSLKRKA---ADEGP-EGRYRKYAYEPAKAPVADGASYPAADNGEC---RGNGF 309
               S  SLKRKA   A +G  +  Y  Y+Y   ++       Y   DN      RGNGF
Sbjct: 308 LTNSSASSLKRKAFYMAGQGDMDSSYGNYSYGQQRS--TQSPMYRMPDNSISNTNRGNGF 365

Query: 310 -------------------------------RAKPPGAAEEASGKYGG--GVPLKVLGSP 336
                                          RA  P +   A    G           SP
Sbjct: 366 DRSAETSSLAFKPTKQLMSSEQQRKFSSQSSRALTPPSYSTAKNSLGSRSSESFGKYTSP 425

Query: 337 V---YGPQLEPFEKFPERAPAPRGGFAVPSG--ETPKGVDPGALELVTSKMVDCGPPVQW 391
           V   +G +       P + P  R   +      E  K  D   ++LVT++++  GPPV W
Sbjct: 426 VMSEHGDEHRQLLSHPMQGPGLRAATSSNHSVDEQLKNTDTHLIDLVTNEIITQGPPVDW 485

Query: 392 ADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGA 451
            D+AG   +KA ++EE++WP+LR  A+ G    PR++LLFGPRG GK LLGRC+A+QLGA
Sbjct: 486 NDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGA 545

Query: 452 TLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPAR-DDGAAAGGAL 510
           T  ++ G+ L A    E  +++ A+F  ARCR PSV+ +S+++ LL ++ ++  +    +
Sbjct: 546 TFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVSRM 605

Query: 511 QVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYVALPDSPARGQILQRA 570
           +   L  LD    +  D ++V+  TS+P  +DE+ RR F  R  + LPDS AR QI+ + 
Sbjct: 606 RTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQL 665

Query: 571 LAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAG-----------AGLPGLQRPLS 619
           L+Q    L+++E A LVQ T+GFSG ++  LCQ+A  G           A +P   RP++
Sbjct: 666 LSQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAVVGPLHAMPATDLSAIMPSQLRPVT 725

Query: 620 YKDLEAALAKVGPRASAKELDSFVEWDKMYG 650
           Y+D E A  K+ P  S KELD +VEW+KM+G
Sbjct: 726 YQDFENAFCKIQPSISQKELDMYVEWNKMFG 756


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  244 bits (622), Expect = 2e-64
 Identities = 144/411 (35%), Positives = 223/411 (54%), Gaps = 38/411 (9%)

Query: 257 PGAESGLSLKRKAADEGPEGRYRKYAYEPAKAPVADGASYPAADN--GECRGNGFRAK-P 313
           P  +S L   + A ++    + +KY ++P +A    G+SY       G  R  G   K  
Sbjct: 286 PKEDSSLPTFKTAKEQLWVDQQKKY-HQPQRA---SGSSYGGVKKSLGASRSRGILGKFV 341

Query: 314 PGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGFAVPSGETPKGVDPG 373
           P   ++  G+  GG+  K  G+   GP  EP               A P  E  K ++P 
Sbjct: 342 PPIPKQDGGEQNGGMQCKPYGA---GPT-EP---------------AHPVDERLKNLEPK 382

Query: 374 ALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGP 433
            +EL+ ++++D GPPV W D+AG    KA ++E +VWP+LRP  + G   PP+ +LLFGP
Sbjct: 383 MIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGP 442

Query: 434 RGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISEL 493
            G GK L+G+C+A+Q GAT   +  ++L +    EG ++++A FA ARC+ P+V+ I E+
Sbjct: 443 PGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEI 502

Query: 494 EALLPARDDGA-AAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLR 552
           ++LL  R DG   +   ++   L  LDG   +  D +LVVG T+RP  +DEA RRR   R
Sbjct: 503 DSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKR 562

Query: 553 FYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAG---- 608
            Y+ LP++ AR QI+   ++++ C LSE E+  +VQ +  FSG ++ QLC++A+ G    
Sbjct: 563 LYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRS 622

Query: 609 -------AGLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYGSG 652
                     P   RP++Y D E A   V P  S K+L+ +  W+K +G G
Sbjct: 623 LQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFGCG 673



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 28/95 (29%), Positives = 51/95 (53%), Gaps = 11/95 (11%)

Query: 11  LNQWPEQHLDVSS---TTP-SPAHKLELPPGGRQRCHYAWAHDDISALTASNLLKRYAEK 66
           L++W + +  ++S   T P + A++ ++      R  YAWA+ +IS + A+ L K+YAEK
Sbjct: 11  LSEWQKNYFAITSGICTGPKADAYRAQI-----LRIQYAWANSEISQVCATKLFKKYAEK 65

Query: 67  YSGVLDSPYERPALGGYSD--ASFLNGAKGDPEPW 99
           YS ++DS      L  Y++   +     + D + W
Sbjct: 66  YSAIIDSDNVESGLNNYAENILTLAGSQQTDSDKW 100


>gi|112789543 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  244 bits (622), Expect = 2e-64
 Identities = 144/411 (35%), Positives = 223/411 (54%), Gaps = 38/411 (9%)

Query: 257 PGAESGLSLKRKAADEGPEGRYRKYAYEPAKAPVADGASYPAADN--GECRGNGFRAK-P 313
           P  +S L   + A ++    + +KY ++P +A    G+SY       G  R  G   K  
Sbjct: 286 PKEDSSLPTFKTAKEQLWVDQQKKY-HQPQRA---SGSSYGGVKKSLGASRSRGILGKFV 341

Query: 314 PGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGFAVPSGETPKGVDPG 373
           P   ++  G+  GG+  K  G+   GP  EP               A P  E  K ++P 
Sbjct: 342 PPIPKQDGGEQNGGMQCKPYGA---GPT-EP---------------AHPVDERLKNLEPK 382

Query: 374 ALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGP 433
            +EL+ ++++D GPPV W D+AG    KA ++E +VWP+LRP  + G   PP+ +LLFGP
Sbjct: 383 MIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGP 442

Query: 434 RGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISEL 493
            G GK L+G+C+A+Q GAT   +  ++L +    EG ++++A FA ARC+ P+V+ I E+
Sbjct: 443 PGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEI 502

Query: 494 EALLPARDDGA-AAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLR 552
           ++LL  R DG   +   ++   L  LDG   +  D +LVVG T+RP  +DEA RRR   R
Sbjct: 503 DSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKR 562

Query: 553 FYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAG---- 608
            Y+ LP++ AR QI+   ++++ C LSE E+  +VQ +  FSG ++ QLC++A+ G    
Sbjct: 563 LYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRS 622

Query: 609 -------AGLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYGSG 652
                     P   RP++Y D E A   V P  S K+L+ +  W+K +G G
Sbjct: 623 LQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFGCG 673



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 28/95 (29%), Positives = 51/95 (53%), Gaps = 11/95 (11%)

Query: 11  LNQWPEQHLDVSS---TTP-SPAHKLELPPGGRQRCHYAWAHDDISALTASNLLKRYAEK 66
           L++W + +  ++S   T P + A++ ++      R  YAWA+ +IS + A+ L K+YAEK
Sbjct: 11  LSEWQKNYFAITSGICTGPKADAYRAQI-----LRIQYAWANSEISQVCATKLFKKYAEK 65

Query: 67  YSGVLDSPYERPALGGYSD--ASFLNGAKGDPEPW 99
           YS ++DS      L  Y++   +     + D + W
Sbjct: 66  YSAIIDSDNVESGLNNYAENILTLAGSQQTDSDKW 100


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  180 bits (456), Expect = 4e-45
 Identities = 107/295 (36%), Positives = 161/295 (54%), Gaps = 12/295 (4%)

Query: 368 KGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRT 427
           + VD     L+ +++VD G  V++ D+AGQ   K AL+E ++ P LRP  + G   P R 
Sbjct: 286 RNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARG 345

Query: 428 VLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSV 487
           +LLFGP G GK +L + +A +  AT   +  A+L +    EG +L++A FA AR   PS+
Sbjct: 346 LLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSI 405

Query: 488 LLISELEALLPARDDGA-AAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATR 546
           + I E+++LL  R +G   A   L+   L   DG   AG D VLV+G T+RP  LDEA  
Sbjct: 406 IFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVL 465

Query: 547 RRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAA 606
           RRF  R YV+LP+   R  +L+  L +QG  L+++ELA L + T G+SG +L  L + AA
Sbjct: 466 RRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAA 525

Query: 607 AGA-----------GLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYG 650
            G                  R +   D   +L K+    S + L++++ W+K +G
Sbjct: 526 LGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 580



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 18/44 (40%), Positives = 19/44 (43%)

Query: 204 NYPAGGYAAQPGYGALPPPPGPPPAPYLTPGLPAPTPLPAPAPP 247
           N P G    +   GA  P P  PP P L P  PA  P P P  P
Sbjct: 2   NSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESP 45


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score =  180 bits (456), Expect = 4e-45
 Identities = 107/295 (36%), Positives = 161/295 (54%), Gaps = 12/295 (4%)

Query: 368 KGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRT 427
           + VD     L+ +++VD G  V++ D+AGQ   K AL+E ++ P LRP  + G   P R 
Sbjct: 318 RNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARG 377

Query: 428 VLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSV 487
           +LLFGP G GK +L + +A +  AT   +  A+L +    EG +L++A FA AR   PS+
Sbjct: 378 LLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSI 437

Query: 488 LLISELEALLPARDDGA-AAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATR 546
           + I E+++LL  R +G   A   L+   L   DG   AG D VLV+G T+RP  LDEA  
Sbjct: 438 IFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVL 497

Query: 547 RRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAA 606
           RRF  R YV+LP+   R  +L+  L +QG  L+++ELA L + T G+SG +L  L + AA
Sbjct: 498 RRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAA 557

Query: 607 AGA-----------GLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYG 650
            G                  R +   D   +L K+    S + L++++ W+K +G
Sbjct: 558 LGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 612



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 18/44 (40%), Positives = 19/44 (43%)

Query: 204 NYPAGGYAAQPGYGALPPPPGPPPAPYLTPGLPAPTPLPAPAPP 247
           N P G    +   GA  P P  PP P L P  PA  P P P  P
Sbjct: 2   NSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESP 45


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  132 bits (332), Expect = 1e-30
 Identities = 91/319 (28%), Positives = 155/319 (48%), Gaps = 28/319 (8%)

Query: 360 AVPSGETPK----GVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRP 415
           AV   ET K    G D   +E +   ++   P V+W D+A     K  L+E +V P+  P
Sbjct: 173 AVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMP 232

Query: 416 PAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQA 475
             + G  RP + VL+ GP G GK LL + +AT+   T   +  +TL +    E  +L++ 
Sbjct: 233 EFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRL 292

Query: 476 AFAAARCRPPSVLLISELEALLPAR--DDGAAAGGALQVPLLACLDGGCGAGADG----- 528
            F  AR   P+ + I E++++   R   +   A   ++  LL  +DG  G   +      
Sbjct: 293 LFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKM 352

Query: 529 VLVVGTTSRPAALDEATRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQ 588
           V+V+  T+ P  +DEA RRR   R Y+ LP +  R ++L+ +L +   A  + +LA++ +
Sbjct: 353 VMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELA-DDVDLASIAE 411

Query: 589 GTQGFSGGELGQLCQQAAAGA------GL----------PGLQRPLSYKDLEAALAKVGP 632
             +G+SG ++  +C+ A+  A      GL            +  P + +D E AL KV  
Sbjct: 412 NMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSK 471

Query: 633 RASAKELDSFVEWDKMYGS 651
             SA +++ + +W   +GS
Sbjct: 472 SVSAADIERYEKWIFEFGS 490


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  132 bits (332), Expect = 1e-30
 Identities = 92/315 (29%), Positives = 151/315 (47%), Gaps = 28/315 (8%)

Query: 364 GETPK----GVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYP 419
           GE PK    G D   +E +   +V   P + W D+A     K  L E +V P+  P  + 
Sbjct: 176 GEMPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFK 235

Query: 420 GSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAA 479
           G  RP + VL+ GP G GK +L + +AT+ G T   +  +TL +    E  +L++  F  
Sbjct: 236 GIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEM 295

Query: 480 ARCRPPSVLLISELEALLPAR--DDGAAAGGALQVPLLACLDGGCGA-----GADGVLVV 532
           AR   P+ + I E++++   R   D   A   ++  LL  +DG  GA      +  V+V+
Sbjct: 296 ARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVL 355

Query: 533 GTTSRPAALDEATRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQG 592
             T+ P  +DEA RRR   R Y+ LP +  R ++L+  L +      + +L  + +  +G
Sbjct: 356 AATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELD-PDIQLEDIAEKIEG 414

Query: 593 FSGGELGQLCQQAAAGA------GL----------PGLQRPLSYKDLEAALAKVGPRASA 636
           +SG ++  +C+ A+  A      GL            LQ P++  D E AL K+    SA
Sbjct: 415 YSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSA 474

Query: 637 KELDSFVEWDKMYGS 651
            +L+ + +W   +GS
Sbjct: 475 ADLEKYEKWMVEFGS 489


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  132 bits (332), Expect = 1e-30
 Identities = 92/315 (29%), Positives = 151/315 (47%), Gaps = 28/315 (8%)

Query: 364 GETPK----GVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYP 419
           GE PK    G D   +E +   +V   P + W D+A     K  L E +V P+  P  + 
Sbjct: 176 GEMPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFK 235

Query: 420 GSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAA 479
           G  RP + VL+ GP G GK +L + +AT+ G T   +  +TL +    E  +L++  F  
Sbjct: 236 GIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEM 295

Query: 480 ARCRPPSVLLISELEALLPAR--DDGAAAGGALQVPLLACLDGGCGA-----GADGVLVV 532
           AR   P+ + I E++++   R   D   A   ++  LL  +DG  GA      +  V+V+
Sbjct: 296 ARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVL 355

Query: 533 GTTSRPAALDEATRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQG 592
             T+ P  +DEA RRR   R Y+ LP +  R ++L+  L +      + +L  + +  +G
Sbjct: 356 AATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELD-PDIQLEDIAEKIEG 414

Query: 593 FSGGELGQLCQQAAAGA------GL----------PGLQRPLSYKDLEAALAKVGPRASA 636
           +SG ++  +C+ A+  A      GL            LQ P++  D E AL K+    SA
Sbjct: 415 YSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSA 474

Query: 637 KELDSFVEWDKMYGS 651
            +L+ + +W   +GS
Sbjct: 475 ADLEKYEKWMVEFGS 489


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score =  127 bits (318), Expect = 4e-29
 Identities = 99/359 (27%), Positives = 163/359 (45%), Gaps = 20/359 (5%)

Query: 254 TAAPGAESGLSLKRKAADEGPEGRYRK--YAYEPAKAPVADGASYPAADNGECRGNGFRA 311
           + +P  +  + L  KAA E   G Y +    Y+ A         Y A   G+      RA
Sbjct: 3   STSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEA--QGDKAKQSIRA 60

Query: 312 KPPGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGFAVPSGETPKGVD 371
           K     + A          + L   +   + +  +   E  P+P       S    +  D
Sbjct: 61  KCTEYLDRA----------EKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDSDGEGESDD 110

Query: 372 PGALEL---VTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTV 428
           P   +L   +   +V   P V+W+DVAG    K AL+E ++ P+  P  + G   P R +
Sbjct: 111 PEKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGI 170

Query: 429 LLFGPRGAGKALLGRCLATQLG-ATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSV 487
           LLFGP G GK+ L + +AT+   +T   +  + L +    E  +L++  F  AR   PS+
Sbjct: 171 LLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSI 230

Query: 488 LLISELEALLPARDDGAA-AGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATR 546
           + I E+++L  +R +  + A   ++   L  + G  G   DG+LV+G T+ P  LD A R
Sbjct: 231 IFIDEIDSLCGSRSENESEAARRIKTEFLVQMQG-VGVDNDGILVLGATNIPWVLDSAIR 289

Query: 547 RRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQA 605
           RRF  R Y+ LP+  AR  + +  L     +L+E +   L + T G+SG ++  + + A
Sbjct: 290 RRFEKRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDA 348


>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
          Length = 437

 Score =  124 bits (310), Expect = 4e-28
 Identities = 71/214 (33%), Positives = 116/214 (54%), Gaps = 3/214 (1%)

Query: 387 PPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLA 446
           P ++W DVAG    K AL+E ++ P+  P  + G   P R +LLFGP G GK+ L + +A
Sbjct: 122 PNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVA 181

Query: 447 TQLG-ATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAA 505
           T+   +T   +  + L +    E  +L++  F  AR   PS++ I E+++L  +R++  +
Sbjct: 182 TEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENES 241

Query: 506 -AGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYVALPDSPARG 564
            A   ++   L  + G  G   DG LV+G T+ P  LD A RRRF  R Y+ LP+  AR 
Sbjct: 242 EAARRIKTEFLVQMQG-VGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARA 300

Query: 565 QILQRALAQQGCALSERELAALVQGTQGFSGGEL 598
           Q+ +  L      L++  +  L + T+G+SG ++
Sbjct: 301 QMFRLHLGSTPHNLTDANIHELARKTEGYSGADI 334


>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score =  114 bits (285), Expect = 3e-25
 Identities = 73/231 (31%), Positives = 120/231 (51%), Gaps = 14/231 (6%)

Query: 387 PPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLA 446
           P ++W D+ G  A K  ++E +V+P+  P  + G L P + +LL+GP G GK LL + +A
Sbjct: 177 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVA 236

Query: 447 TQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAA 506
           T+   T   +  +T+ +    +  +L++  F  AR   PS + + ELE+++  R  G A+
Sbjct: 237 TECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQR--GTAS 294

Query: 507 GG------ALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYVALPDS 560
           GG       ++  LL  +D G     D V V+  ++ P  LD A  RR   R  V LP  
Sbjct: 295 GGEHEGSLRMKTELLVQMD-GLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLPSR 353

Query: 561 PARGQILQRAL--AQQGCAL---SERELAALVQGTQGFSGGELGQLCQQAA 606
            AR  ++   L    +  AL   +E E + L Q T+G+SG ++  +C++AA
Sbjct: 354 EARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAA 404


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  113 bits (283), Expect = 5e-25
 Identities = 79/254 (31%), Positives = 123/254 (48%), Gaps = 10/254 (3%)

Query: 387 PPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGRCL 445
           P V W+D+ G  ++K  LE+ + WPL  P ++    ++PP+ VLL+GP G  K ++ + L
Sbjct: 622 PNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKAL 681

Query: 446 ATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAA 505
           A + G   L ++G  L      E  R ++  F  AR   PS++   EL+AL   R     
Sbjct: 682 ANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLG 741

Query: 506 AGGA---LQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYVALPDS 560
           AG     +   LL  +DG        V ++  T+RP  +D+A  R  R     YV LPD+
Sbjct: 742 AGNVADRVLAQLLTEMDG--IEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDA 799

Query: 561 PARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAGAGLPGLQRPLSY 620
             R +I +        + +E +L  L+  T  +SG E+  +C++AA  A    +Q  L  
Sbjct: 800 ATRREIFKLQFHSMPVS-NEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANLIM 858

Query: 621 K-DLEAALAKVGPR 633
           K     AL+ V PR
Sbjct: 859 KRHFTQALSTVTPR 872



 Score =  110 bits (276), Expect = 3e-24
 Identities = 82/244 (33%), Positives = 120/244 (49%), Gaps = 9/244 (3%)

Query: 380 SKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGK 438
           SK  D    V +  + G  +   A+ E +  PL +P  +    +  PR VLL+GP G GK
Sbjct: 341 SKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGK 400

Query: 439 ALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLP 498
            ++ R +A ++GA +  + G  + +    E    L+  FA A  R PS++ I EL+AL P
Sbjct: 401 TMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCP 460

Query: 499 ARDDGA-AAGGALQVPLLACLDG-GCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFY 554
            R+         +   LL  +DG G       VLV+G T+RP ALD A RR  RF     
Sbjct: 461 KREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIE 520

Query: 555 VALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAGAGLPGL 614
           + +P++  R  ILQ+ L +    L+E EL  L     G+ G +L  LC +    AGL  L
Sbjct: 521 IGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNE----AGLCAL 576

Query: 615 QRPL 618
           +R L
Sbjct: 577 RRIL 580


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  107 bits (268), Expect = 3e-23
 Identities = 68/221 (30%), Positives = 112/221 (50%), Gaps = 4/221 (1%)

Query: 389 VQWADVAGQGALKAALEEELVWPLLRPPAYPGS--LRPPRTVLLFGPRGAGKALLGRCLA 446
           V W+D+AG   +   L++ ++ P+ +   +  S  L+PP+ VLL+GP G GK L+ +  A
Sbjct: 88  VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATA 147

Query: 447 TQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDG-AA 505
            + G   + L+ +TL      E  +L  A F+ A    PS++ I E+++ L  R      
Sbjct: 148 KEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHE 207

Query: 506 AGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYVALPDSPARGQ 565
           A   ++   ++  DG     +  V+V+G T+RP  LD A  RR   RF++  P    R  
Sbjct: 208 ATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREA 267

Query: 566 ILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAA 606
           IL+  L  +       +L  + Q T GFSG +L ++C+ AA
Sbjct: 268 ILKLILKNENVD-RHVDLLEVAQETDGFSGSDLKEMCRDAA 307


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  103 bits (256), Expect = 7e-22
 Identities = 70/226 (30%), Positives = 110/226 (48%), Gaps = 10/226 (4%)

Query: 387 PPVQWADVAGQGALKAALEEELVWPLLRPPAY-PGSLRPPRTVLLFGPRGAGKALLGRCL 445
           P V W D+ G   +K  L+E + +P+  P  +    + P + VL +GP G GK LL + +
Sbjct: 472 PQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAI 531

Query: 446 ATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPAR----D 501
           A +  A  + ++G  L      E    ++  F  AR   P VL   EL+++  AR     
Sbjct: 532 ANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIG 591

Query: 502 DGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYVALPD 559
           DG  A   +   +L  +DG   +    V ++G T+RP  +D A  R  R     Y+ LPD
Sbjct: 592 DGGGAADRVINQILTEMDG--MSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPD 649

Query: 560 SPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQA 605
             +R  IL+  L +   A  + +L  L + T GFSG +L ++CQ+A
Sbjct: 650 EKSRVAILKANLRKSPVA-KDVDLEFLAKMTNGFSGADLTEICQRA 694



 Score =  100 bits (249), Expect = 4e-21
 Identities = 73/239 (30%), Positives = 114/239 (47%), Gaps = 9/239 (3%)

Query: 389 VQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGRCLAT 447
           V + D+ G     A ++E +  PL  P  +    ++PPR +LL+GP G GK L+ R +A 
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260

Query: 448 QLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAAG 507
           + GA    + G  + +  A E    L+ AF  A    P+++ I EL+A+ P R+      
Sbjct: 261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEV 320

Query: 508 GALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYVALPDSPARGQ 565
               V  L  L  G    A  V+V+  T+RP ++D A RR  RF     + +PD+  R +
Sbjct: 321 ERRIVSQLLTLMDGLKQRAH-VIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLE 379

Query: 566 ILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAGAGLPGLQRPLSYKDLE 624
           ILQ        A  + +L  +   T G  G +L  LC +AA    L  +++ +   DLE
Sbjct: 380 ILQIHTKNMKLA-DDVDLEQVANETHGHVGADLAALCSEAA----LQAIRKKMDLIDLE 433


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score = 96.3 bits (238), Expect = 8e-20
 Identities = 81/281 (28%), Positives = 123/281 (43%), Gaps = 19/281 (6%)

Query: 343 EPFEKFPERAPAPRGGFAVPSGETPKGVDPGALE---LVTSKMVDCGP-----PVQWADV 394
           E FE+   ++ A      +P     + +  G L     V + + D  P      V++  +
Sbjct: 343 ERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSI 402

Query: 395 AGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGRCLATQLG--- 450
            G      AL+E +V+PLL P  +    ++PPR  L +GP G GK L+ R LA +     
Sbjct: 403 GGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGD 462

Query: 451 --ATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGA-AAG 507
                   +GA   +    E  R L+  F  A    PS++   E++ L P R        
Sbjct: 463 KKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIH 522

Query: 508 GALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYVALPDSPARGQ 565
            ++   LLA +DG    G   ++V+G T+R  ++D A RR  RF   F   LPD  AR  
Sbjct: 523 SSIVSTLLALMDGLDNRGE--IVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKH 580

Query: 566 ILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAA 606
           ILQ         LS+  L  L +   G+ G ++  LC +AA
Sbjct: 581 ILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAA 621


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 80/269 (29%), Positives = 126/269 (46%), Gaps = 17/269 (6%)

Query: 378 VTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGA 436
           V +  VD  P  Q++D+ G       L E +V P+     +    ++PP+ VL++GP G 
Sbjct: 172 VKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGT 231

Query: 437 GKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEAL 496
           GK LL R  A Q  AT L+L G  L      +GA+L++ AFA A+ + PS++ I EL+A+
Sbjct: 232 GKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAI 291

Query: 497 LPARDDGAAAGG----ALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRR--RFS 550
              R D   AG        + LL  LDG        V V+  T+R   LD A  R  R  
Sbjct: 292 GTKRFDSEKAGDREVQRTMLELLNQLDG--FQPNTQVKVIAATNRVDILDPALLRSGRLD 349

Query: 551 LRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAGAG 610
            +    +P+  AR +I+Q    +   +  +     L + T  F+G +    C+     AG
Sbjct: 350 RKIEFPMPNEEARARIMQIHSRKMNVS-PDVNYEELARCTDDFNGAQ----CKAVCVEAG 404

Query: 611 LPGLQR---PLSYKDLEAALAKVGPRASA 636
           +  L+R    L+++D    + +V  +  A
Sbjct: 405 MIALRRGATELTHEDYMEGILEVQAKKKA 433


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 80/269 (29%), Positives = 124/269 (46%), Gaps = 11/269 (4%)

Query: 367 PKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPP 425
           P  +DP     VT   V+  P V ++DV G       L E +  PLL P  +    + PP
Sbjct: 154 PPKIDP----TVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPP 209

Query: 426 RTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPP 485
           + VLLFGP G GK L  R +A +  A  +R+ G+ L      EGAR+++  F  AR +  
Sbjct: 210 KGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKA 269

Query: 486 SVLLISELEALLPAR-DDGAAAGGALQVPLLACLDGGCGAGADG-VLVVGTTSRPAALDE 543
            ++   E++A+  AR DDGA     +Q  +L  ++   G    G + V+  T+RP  LD 
Sbjct: 270 CLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDP 329

Query: 544 ATRR--RFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQL 601
           A  R  R   +   +LPD   R  I  +  A+      +     L +     +G E+  +
Sbjct: 330 ALMRPGRLDRKIEFSLPDLEGRTHIF-KIHARSMSVERDIRFELLARLCPNSTGAEIRSV 388

Query: 602 CQQAAAGAGLPGLQRPLSYKDLEAALAKV 630
           C +A   A +   ++  + KD   A+ KV
Sbjct: 389 CTEAGMFA-IRARRKIATEKDFLEAVNKV 416


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 87/258 (33%), Positives = 117/258 (45%), Gaps = 17/258 (6%)

Query: 364 GETPKGVDPGALELVTSKMVDCGPPVQWAD------VAGQGALKAALEEELVWPLLRPPA 417
           G TP   DP  L    +++   G P   A       + G      +L E L  PL  P A
Sbjct: 167 GGTPSP-DPAGLVTPRTRVSLGGEPPSEAQPQPEVPLGGLSEAADSLRELLRLPLRYPRA 225

Query: 418 YPG-SLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAA 476
                L  PR VLL GP G GK  L R +A + GA LL +    L      E    ++  
Sbjct: 226 LTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGETEENVRRV 285

Query: 477 FAAAR---CRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVG 533
           F  AR    R PS+L + E++AL P R   A     +   +L  LDG   +G   V+VVG
Sbjct: 286 FQRARELASRGPSLLFLDEMDALCPQRGSRAPESRVV-AQVLTLLDG--ASGDREVVVVG 342

Query: 534 TTSRPAALDEATRR--RFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQ 591
            T+RP ALD A RR  RF     +  P    R +ILQ   ++   + S  +L  L + T 
Sbjct: 343 ATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPIS-SHVDLGLLAEMTV 401

Query: 592 GFSGGELGQLCQQAAAGA 609
           G+ G +L  LC++AA  A
Sbjct: 402 GYVGADLTALCREAAMHA 419



 Score = 89.7 bits (221), Expect = 7e-18
 Identities = 76/267 (28%), Positives = 112/267 (41%), Gaps = 30/267 (11%)

Query: 365 ETPKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLR 423
           E  K + P +   V   M     PV W ++ G   +K  L++ + WPL  P  +    L 
Sbjct: 439 EAFKNIQPSSFRSVIGLMDI--KPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLT 496

Query: 424 PPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCR 483
            P+ VLL+GP G  K  L R LAT    + + + GA L +P   +  ++L   F  AR  
Sbjct: 497 QPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARAS 556

Query: 484 PPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGAD---------------- 527
            P++L + E++++L AR          +  L   L+   G G                  
Sbjct: 557 TPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQE 616

Query: 528 ----GVLVVGTTSRPAALDEATRR--RFSLRFYVALPDSPARGQILQRALAQQ--GCALS 579
                V+++  T+RP  LD A  R  R     Y+  PD   R  IL+        G  +S
Sbjct: 617 VFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVS 676

Query: 580 ERELAALVQGTQGFSGGELGQLCQQAA 606
              LAA    T  FSG +L  LC +AA
Sbjct: 677 LENLAA---ETCFFSGADLRNLCTEAA 700


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 69/227 (30%), Positives = 106/227 (46%), Gaps = 11/227 (4%)

Query: 389 VQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLGRCLAT 447
           V++  V G     AAL+E +V+PLL P  +    ++PPR  L +GP G GK L+ R LA 
Sbjct: 423 VRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 482

Query: 448 QLG-----ATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDD 502
           +             +GA   +    E  R L+  F  A    PS++   E++ L P R  
Sbjct: 483 ECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSS 542

Query: 503 GA-AAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYVALPD 559
                  ++   LLA +DG    G   ++V+G T+R  ++D A RR  RF   F  +LPD
Sbjct: 543 RQDQIHSSIVSTLLALMDGLDSRGE--IVVIGATNRLDSIDPALRRPGRFDREFLFSLPD 600

Query: 560 SPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAA 606
             AR +IL+           +  L  L +   G+ G ++  +C +AA
Sbjct: 601 KEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAA 647


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 71/236 (30%), Positives = 110/236 (46%), Gaps = 10/236 (4%)

Query: 377 LVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRG 435
           LVT   V+  P   +AD+ G       ++E +  PL  P  Y    ++PP+ V+L+GP G
Sbjct: 170 LVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPG 229

Query: 436 AGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEA 495
            GK LL + +A Q  AT LR+ G+ L      +G +L++  F  A    PS++ I E++A
Sbjct: 230 TGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDA 289

Query: 496 LLPARDDGAAAG----GALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRR--RF 549
           +   R D  + G        + LL  LDG    G   V V+  T+R   LD A  R  R 
Sbjct: 290 IGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRG--DVKVIMATNRIETLDPALIRPGRI 347

Query: 550 SLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQA 605
             +    LPD   + +I Q   ++   A  +  L  L+      SG ++  +C +A
Sbjct: 348 DRKIEFPLPDEKTKKRIFQIHTSRMTLA-DDVTLDDLIMAKDDLSGADIKAICTEA 402


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 62/187 (33%), Positives = 94/187 (50%), Gaps = 5/187 (2%)

Query: 424 PPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCR 483
           PPR VLL GP G GK LL   +A +L   +L++    + +  + E  + L+  F  A   
Sbjct: 191 PPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSN 250

Query: 484 PPSVLLISELEALLPARDDGAA-AGGALQVPLLACLDGGCGAGADG-VLVVGTTSRPAAL 541
            P ++ I E++A+ P R+  +      +   LL C+D      A   VLV+G T+RP +L
Sbjct: 251 APCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSL 310

Query: 542 DEATRR--RFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELG 599
           D A RR  RF     + +PD  +R +ILQ  L ++       +   L   T GF G +L 
Sbjct: 311 DPALRRAGRFDREICLGIPDEASRERILQ-TLCRKLRLPQAFDFCHLAHLTPGFVGADLM 369

Query: 600 QLCQQAA 606
            LC++AA
Sbjct: 370 ALCREAA 376



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 78/276 (28%), Positives = 118/276 (42%), Gaps = 32/276 (11%)

Query: 387 PPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRP-----PRTVLLFGPRGAGKALL 441
           P V WAD+   GAL+  + EEL   +L P   P   +      P  VLL GP G GK LL
Sbjct: 470 PNVTWADI---GALED-IREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLL 525

Query: 442 GRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARD 501
            + +A + G   + ++G  L      E  R ++  F  A+   P V+   E++AL P R 
Sbjct: 526 AKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRS 585

Query: 502 DGAAAGGALQV--PLLACLDGGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYVAL 557
           D    G +++V   LL  +DG        V ++  T+RP  +D A  R  R     +V L
Sbjct: 586 D-RETGASVRVVNQLLTEMDG--LEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGL 642

Query: 558 PDSPARGQILQRALAQQGC-----ALSERELAALVQGTQGFSGGELGQLCQQAAAGAGLP 612
           P  PA    + + + + G      A    E  A       ++G +L  L ++A+  A   
Sbjct: 643 P-PPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ 701

Query: 613 GLQR----------PLSYKDLEAALAKVGPRASAKE 638
            + R           +S+K  E A  KV    S K+
Sbjct: 702 EMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKD 737


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 62/187 (33%), Positives = 94/187 (50%), Gaps = 5/187 (2%)

Query: 424 PPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCR 483
           PPR VLL GP G GK LL   +A +L   +L++    + +  + E  + L+  F  A   
Sbjct: 297 PPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSN 356

Query: 484 PPSVLLISELEALLPARDDGAA-AGGALQVPLLACLDGGCGAGADG-VLVVGTTSRPAAL 541
            P ++ I E++A+ P R+  +      +   LL C+D      A   VLV+G T+RP +L
Sbjct: 357 APCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSL 416

Query: 542 DEATRR--RFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELG 599
           D A RR  RF     + +PD  +R +ILQ  L ++       +   L   T GF G +L 
Sbjct: 417 DPALRRAGRFDREICLGIPDEASRERILQ-TLCRKLRLPQAFDFCHLAHLTPGFVGADLM 475

Query: 600 QLCQQAA 606
            LC++AA
Sbjct: 476 ALCREAA 482



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 78/276 (28%), Positives = 118/276 (42%), Gaps = 32/276 (11%)

Query: 387 PPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRP-----PRTVLLFGPRGAGKALL 441
           P V WAD+   GAL+  + EEL   +L P   P   +      P  VLL GP G GK LL
Sbjct: 576 PNVTWADI---GALED-IREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLL 631

Query: 442 GRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARD 501
            + +A + G   + ++G  L      E  R ++  F  A+   P V+   E++AL P R 
Sbjct: 632 AKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRS 691

Query: 502 DGAAAGGALQV--PLLACLDGGCGAGADGVLVVGTTSRPAALDEATRR--RFSLRFYVAL 557
           D    G +++V   LL  +DG        V ++  T+RP  +D A  R  R     +V L
Sbjct: 692 D-RETGASVRVVNQLLTEMDG--LEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGL 748

Query: 558 PDSPARGQILQRALAQQGC-----ALSERELAALVQGTQGFSGGELGQLCQQAAAGAGLP 612
           P  PA    + + + + G      A    E  A       ++G +L  L ++A+  A   
Sbjct: 749 P-PPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ 807

Query: 613 GLQR----------PLSYKDLEAALAKVGPRASAKE 638
            + R           +S+K  E A  KV    S K+
Sbjct: 808 EMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKD 843


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 81/288 (28%), Positives = 134/288 (46%), Gaps = 19/288 (6%)

Query: 367 PKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPP 425
           P  VDP    LV+  MV+  P   +  + G       ++E +  P+  P  +    +  P
Sbjct: 128 PNKVDP----LVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQP 183

Query: 426 RTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPP 485
           + VLL+GP G GK LL R +A     T +R+ G+ L      EGAR+++  F  AR   P
Sbjct: 184 KGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAP 243

Query: 486 SVLLISELEALLPARDDGAAAGGA----LQVPLLACLDGGCGAGADGVLVVGTTSRPAAL 541
           S++ + E++++  +R +G + G +      + LL  LDG        + V+  T+R   L
Sbjct: 244 SIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDG--FEATKNIKVIMATNRIDIL 301

Query: 542 DEATRR--RFSLRFYVALPDSPARGQILQRALAQQGC--ALSERELAALVQGTQGFSGGE 597
           D A  R  R   +     P+  AR  IL+    +      ++ R++A L+ G    SG E
Sbjct: 302 DSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGA---SGAE 358

Query: 598 LGQLCQQAAAGAGLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEW 645
           +  +C +A   A L   +  ++ +D E A+AKV  + S K +     W
Sbjct: 359 VKGVCTEAGMYA-LRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLW 405


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 78/284 (27%), Positives = 137/284 (48%), Gaps = 14/284 (4%)

Query: 367 PKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPP 425
           P+ VDP    LV +   +    V ++++ G       L E +  PL  P  +    + PP
Sbjct: 126 PREVDP----LVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPP 181

Query: 426 RTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPP 485
           +  LL+GP G GK LL R +A+QL    L++  +++      E ARL++  F  AR   P
Sbjct: 182 KGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQP 241

Query: 486 SVLLISELEALLPAR-DDGAAAGGALQVPLLACLDGGCGAGA-DGVLVVGTTSRPAALDE 543
            ++ + E++A+   R  +G +A   +Q  L+  L+   G      V ++  T+RP  LD 
Sbjct: 242 CIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDP 301

Query: 544 ATRR--RFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQL 601
           A  R  R   + ++ LP+  AR  IL +  A       E +  A+V+ + GF+G +L  +
Sbjct: 302 ALLRPGRLDRKIHIDLPNEQARLDIL-KIHAGPITKHGEIDYEAIVKLSDGFNGADLRNV 360

Query: 602 CQQAAAGAGLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEW 645
           C +    AG+  ++    +   E  +  V   A +K+L+S +++
Sbjct: 361 CTE----AGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDY 400


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 84/271 (30%), Positives = 118/271 (43%), Gaps = 21/271 (7%)

Query: 387 PPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLA 446
           P V W DV G   +K  + E +  PL  P      LR    +LL GP G GK LL + +A
Sbjct: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSG-LLLHGPPGTGKTLLAKAVA 758

Query: 447 TQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAA 506
           T+   T L ++G  L      +    ++  FA AR   P ++   EL++L P+R     +
Sbjct: 759 TECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDS 818

Query: 507 GGALQ---VPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRR--RF-SLRFYVALPDS 560
           GG +      LLA LDG        V V+G T+RP  LD A  R  RF  L F  A  D 
Sbjct: 819 GGVMDRVVSQLLAELDG--LHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDR 876

Query: 561 PARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAGA----------G 610
            ++ ++L     +     S   +  L       +G +L  LC  A   A          G
Sbjct: 877 ASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEG 936

Query: 611 L-PGLQR-PLSYKDLEAALAKVGPRASAKEL 639
           L PG     L+ +DL  A A++ P  S +EL
Sbjct: 937 LEPGSSALMLTMEDLLQAAARLQPSVSEQEL 967



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 86/294 (29%), Positives = 117/294 (39%), Gaps = 19/294 (6%)

Query: 332 VLGSPVYGPQLEPFEKFPERAPAPRGGFAVPS---GETPKGVDPGALELVTSKMV----D 384
           VL  P  G Q+E  E  PE+ P  R  F       GE P G     L   T   +     
Sbjct: 356 VLCVPTIG-QVEILEGSPEKLPRWREMFFKVKKTVGEAPDGPASAYLADTTHTSLYMVGS 414

Query: 385 CGPPVQWADVAGQGALKAALE----EELVWPL---LRPPAYPGS--LRPPRTVLLFGPRG 435
              PV W   + +  L ++L     E LV  L   L+P   PG   L    +VLL GP G
Sbjct: 415 TLSPVPWLP-SEESTLWSSLSPPGLEALVSELCAVLKPRLQPGGALLTGTSSVLLRGPPG 473

Query: 436 AGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEA 495
            GK  +     + LG  LL++  ++L A  +      LQA F+ AR   P+VLL++ ++ 
Sbjct: 474 CGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDL 533

Query: 496 LLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYV 555
           L   RD        + V     L+         ++VV TTSR   L    +  F     V
Sbjct: 534 LGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEV 593

Query: 556 ALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAGA 609
                  R  IL RAL        E  LA L +   GF  G+L  L   ++  A
Sbjct: 594 PALSEGQRLSIL-RALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAA 646


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 71/223 (31%), Positives = 109/223 (48%), Gaps = 10/223 (4%)

Query: 425 PRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRP 484
           P+ +LL GP G GK LL R +A +         G+         GA  ++  F  A+   
Sbjct: 372 PKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANA 431

Query: 485 PSVLLISELEALLPARDDGAAAGGALQV--PLLACLDGGCGAGADGVLVVGTTSRPAALD 542
           P V+ I EL+++   R +      + Q    LLA +DG      +GV+++G T+ P ALD
Sbjct: 432 PCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDG--FKPNEGVIIIGATNFPEALD 489

Query: 543 EATRR--RFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQ 600
            A  R  RF ++  V  PD   R +IL+  L +     S  +   + +GT GFSG EL  
Sbjct: 490 NALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSV-DPEIIARGTVGFSGAELEN 548

Query: 601 LCQQAAAGAGLPGLQRPLSYKDLEAALAKV--GPRASAKELDS 641
           L  QAA  A + G +  ++ K+LE +  K+  GP   + E+D+
Sbjct: 549 LVNQAALKAAVDG-KEMVTMKELEFSKDKILMGPERRSVEIDN 590


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 71/223 (31%), Positives = 109/223 (48%), Gaps = 10/223 (4%)

Query: 425 PRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRP 484
           P+ +LL GP G GK LL R +A +         G+         GA  ++  F  A+   
Sbjct: 315 PKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANA 374

Query: 485 PSVLLISELEALLPARDDGAAAGGALQV--PLLACLDGGCGAGADGVLVVGTTSRPAALD 542
           P V+ I EL+++   R +      + Q    LLA +DG      +GV+++G T+ P ALD
Sbjct: 375 PCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDG--FKPNEGVIIIGATNFPEALD 432

Query: 543 EATRR--RFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQ 600
            A  R  RF ++  V  PD   R +IL+  L +     S  +   + +GT GFSG EL  
Sbjct: 433 NALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSV-DPEIIARGTVGFSGAELEN 491

Query: 601 LCQQAAAGAGLPGLQRPLSYKDLEAALAKV--GPRASAKELDS 641
           L  QAA  A + G +  ++ K+LE +  K+  GP   + E+D+
Sbjct: 492 LVNQAALKAAVDG-KEMVTMKELEFSKDKILMGPERRSVEIDN 533


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 63/227 (27%), Positives = 102/227 (44%), Gaps = 6/227 (2%)

Query: 384 DCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLG 442
           D  P V +AD+ G    K  + E +  PL     Y    + PPR VL++GP G GK +L 
Sbjct: 153 DQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLA 212

Query: 443 RCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDD 502
           + +A    A  +R+ G+        EG R+++  F  A+   P+++ I E++A+   R D
Sbjct: 213 KAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD 272

Query: 503 G-AAAGGALQVPLLACLDGGCGAGAD-GVLVVGTTSRPAALDEATRR--RFSLRFYVALP 558
               A   +Q  LL  L+   G   +  V V+  T+R   LD A  R  R   +    LP
Sbjct: 273 AQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLP 332

Query: 559 DSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQA 605
           D   +  I     ++   +  E +L   V      SG ++  +CQ++
Sbjct: 333 DRRQKRLIFSTITSKMNLS-EEVDLEDYVARPDKISGADINSICQES 378


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 63/227 (27%), Positives = 102/227 (44%), Gaps = 6/227 (2%)

Query: 384 DCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG-SLRPPRTVLLFGPRGAGKALLG 442
           D  P V +AD+ G    K  + E +  PL     Y    + PPR VL++GP G GK +L 
Sbjct: 126 DQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLA 185

Query: 443 RCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDD 502
           + +A    A  +R+ G+        EG R+++  F  A+   P+++ I E++A+   R D
Sbjct: 186 KAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD 245

Query: 503 G-AAAGGALQVPLLACLDGGCGAGAD-GVLVVGTTSRPAALDEATRR--RFSLRFYVALP 558
               A   +Q  LL  L+   G   +  V V+  T+R   LD A  R  R   +    LP
Sbjct: 246 AQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLP 305

Query: 559 DSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQA 605
           D   +  I     ++   +  E +L   V      SG ++  +CQ++
Sbjct: 306 DRRQKRLIFSTITSKMNLS-EEVDLEDYVARPDKISGADINSICQES 351


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.137    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,939,838
Number of Sequences: 37866
Number of extensions: 2884943
Number of successful extensions: 41564
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 703
Number of HSP's successfully gapped in prelim test: 1688
Number of HSP's that attempted gapping in prelim test: 14102
Number of HSP's gapped (non-prelim): 12056
length of query: 653
length of database: 18,247,518
effective HSP length: 109
effective length of query: 544
effective length of database: 14,120,124
effective search space: 7681347456
effective search space used: 7681347456
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.