Search of human proteins with 226371754

Search of human proteins with 226371754

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
         (466 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]              927   0.0  
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     276   4e-74
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               268   8e-72
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               268   8e-72
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]         244   2e-64
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]          243   4e-64
gi|31742536 fidgetin-like 1 [Homo sapiens]                            223   2e-58
gi|112789543 fidgetin-like 1 [Homo sapiens]                           223   2e-58
gi|40806170 spastin isoform 2 [Homo sapiens]                          215   6e-56
gi|11875211 spastin isoform 1 [Homo sapiens]                          215   6e-56
gi|64084766 fidgetin [Homo sapiens]                                   180   2e-45
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     171   1e-42
gi|6005942 valosin-containing protein [Homo sapiens]                  160   2e-39
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              160   2e-39
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           155   1e-37
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            145   6e-35
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           145   1e-34
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            143   3e-34
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            142   6e-34
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   137   2e-32
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   137   2e-32
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   137   2e-32
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   133   4e-31
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 131   1e-30
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 131   1e-30
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     129   6e-30
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]            128   1e-29
gi|4505725 peroxin1 [Homo sapiens]                                    127   3e-29
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]              127   3e-29
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             125   6e-29

>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score =  927 bits (2397), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MEYESYYFVKFQKYPKIVKKSSDTAENNLPQRSRGKTRRMMNDSCQNLPKINQQRPRSKT 60
           MEYESYYFVKFQKYPKIVKKSSDTAENNLPQRSRGKTRRMMNDSCQNLPKINQQRPRSKT
Sbjct: 1   MEYESYYFVKFQKYPKIVKKSSDTAENNLPQRSRGKTRRMMNDSCQNLPKINQQRPRSKT 60

Query: 61  TAGKTGDTKSLNKEHPNQEVVDNTRLESANFGLHISRIRKDSGEENAHPRRGQIIDFQGL 120
           TAGKTGDTKSLNKEHPNQEVVDNTRLESANFGLHISRIRKDSGEENAHPRRGQIIDFQGL
Sbjct: 61  TAGKTGDTKSLNKEHPNQEVVDNTRLESANFGLHISRIRKDSGEENAHPRRGQIIDFQGL 120

Query: 121 LTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIK 180
           LTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIK
Sbjct: 121 LTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIK 180

Query: 181 WNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECK 240
           WNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECK
Sbjct: 181 WNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECK 240

Query: 241 TTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEG 300
           TTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEG
Sbjct: 241 TTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEG 300

Query: 301 SLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMI 360
           SLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMI
Sbjct: 301 SLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMI 360

Query: 361 YHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQS 420
           YHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQS
Sbjct: 361 YHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQS 420

Query: 421 ESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLAQRYSDWQREFESV 466
           ESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLAQRYSDWQREFESV
Sbjct: 421 ESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLAQRYSDWQREFESV 466


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  276 bits (705), Expect = 4e-74
 Identities = 146/312 (46%), Positives = 214/312 (68%), Gaps = 18/312 (5%)

Query: 162 RELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLY 221
           ++L   + RDI   NPN++W+DI  L  AK+L+KEAVV P+  P+ F GI  PWKG+L+ 
Sbjct: 189 KDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMV 248

Query: 222 GPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLD 281
           GPPGTGKTLLAKAVATECKTTFFN+S+ST+ SK+RG+SEKLVR+LFE+AR+++P+TIF+D
Sbjct: 249 GPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFID 308

Query: 282 ELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSED------LVFVLAASNLPWELD 335
           E++S+ S+RGT+   EHE S R+K ELLVQMDG+  + +      +V VLAA+N PW++D
Sbjct: 309 EIDSICSRRGTSE--EHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDID 366

Query: 336 CAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSD 395
            A+ RRLEKRI + LPS + R+ ++   L      R LEL  +++ + +++  EGYSG+D
Sbjct: 367 EALRRRLEKRIYIPLPSAKGREELLRISL------RELELADDVDLASIAENMEGYSGAD 420

Query: 396 IKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLA-- 453
           I  VCR+A++  +R+  + L     E  +L + ++ + TT +  ++       + + A  
Sbjct: 421 ITNVCRDASLMAMRRRIEGLT--PEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADI 478

Query: 454 QRYSDWQREFES 465
           +RY  W  EF S
Sbjct: 479 ERYEKWIFEFGS 490


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  268 bits (685), Expect = 8e-72
 Identities = 144/314 (45%), Positives = 212/314 (67%), Gaps = 22/314 (7%)

Query: 162 RELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLY 221
           ++L   + RDI   NP+I W+DI  L+ AK+L++EAVV P+  P  F GI  PWKG+L+ 
Sbjct: 188 KDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMV 247

Query: 222 GPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLD 281
           GPPGTGKT+LAKAVATEC TTFFN+S+ST+ SK+RG+SEKLVR+LFE+AR++AP+TIF+D
Sbjct: 248 GPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFID 307

Query: 282 ELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARS------EDLVFVLAASNLPWELD 335
           E++S+ S+RGT+   EHE S R+K+ELL+QMDG+  +        +V VLAA+N PW++D
Sbjct: 308 EIDSICSRRGTSD--EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365

Query: 336 CAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSD 395
            A+ RRLEKRI + LP+ + R  ++   L      R +EL  +++   ++++ EGYSG+D
Sbjct: 366 EALRRRLEKRIYIPLPTAKGRAELLKINL------REVELDPDIQLEDIAEKIEGYSGAD 419

Query: 396 IKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLA-- 453
           I  VCR+A++  +R+  + L   +  +     +Q+  VT  DF   L   K  AK+++  
Sbjct: 420 ITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMP-VTKGDFELAL---KKIAKSVSAA 475

Query: 454 --QRYSDWQREFES 465
             ++Y  W  EF S
Sbjct: 476 DLEKYEKWMVEFGS 489


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  268 bits (685), Expect = 8e-72
 Identities = 144/314 (45%), Positives = 212/314 (67%), Gaps = 22/314 (7%)

Query: 162 RELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLY 221
           ++L   + RDI   NP+I W+DI  L+ AK+L++EAVV P+  P  F GI  PWKG+L+ 
Sbjct: 188 KDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMV 247

Query: 222 GPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLD 281
           GPPGTGKT+LAKAVATEC TTFFN+S+ST+ SK+RG+SEKLVR+LFE+AR++AP+TIF+D
Sbjct: 248 GPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFID 307

Query: 282 ELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARS------EDLVFVLAASNLPWELD 335
           E++S+ S+RGT+   EHE S R+K+ELL+QMDG+  +        +V VLAA+N PW++D
Sbjct: 308 EIDSICSRRGTSD--EHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365

Query: 336 CAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSD 395
            A+ RRLEKRI + LP+ + R  ++   L      R +EL  +++   ++++ EGYSG+D
Sbjct: 366 EALRRRLEKRIYIPLPTAKGRAELLKINL------REVELDPDIQLEDIAEKIEGYSGAD 419

Query: 396 IKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLA-- 453
           I  VCR+A++  +R+  + L   +  +     +Q+  VT  DF   L   K  AK+++  
Sbjct: 420 ITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMP-VTKGDFELAL---KKIAKSVSAA 475

Query: 454 --QRYSDWQREFES 465
             ++Y  W  EF S
Sbjct: 476 DLEKYEKWMVEFGS 489


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score =  244 bits (622), Expect = 2e-64
 Identities = 126/256 (49%), Positives = 176/256 (68%), Gaps = 9/256 (3%)

Query: 160 EMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLL 219
           E ++L   +   I +  PN+KW+D+ GL+ AK+ +KEAV+ PI++P LFTG  +PW+G+L
Sbjct: 112 EKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGIL 171

Query: 220 LYGPPGTGKTLLAKAVATEC-KTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTI 278
           L+GPPGTGK+ LAKAVATE   +TFF+IS+S +VSKW G+SEKLV+ LF+LAR + PS I
Sbjct: 172 LFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSII 231

Query: 279 FLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAM 338
           F+DE++S+    G+ S  E E + R+KTE LVQM G+    D + VL A+N+PW LD A+
Sbjct: 232 FIDEIDSLC---GSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAI 288

Query: 339 LRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKL 398
            RR EKRI + LP   AR AM    L     S      TE ++  L ++T+GYSG+DI +
Sbjct: 289 RRRFEKRIYIPLPEPHARAAMFKLHLGTTQNSL-----TEADFRELGRKTDGYSGADISI 343

Query: 399 VCREAAMRPVRKIFDA 414
           + R+A M+PVRK+  A
Sbjct: 344 IVRDALMQPVRKVQSA 359


>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
          Length = 437

 Score =  243 bits (619), Expect = 4e-64
 Identities = 124/260 (47%), Positives = 176/260 (67%), Gaps = 9/260 (3%)

Query: 156 GMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPW 215
           G N E ++L   +   + +  PNI+WND+ GL+ AK+ +KEAV+ PI++P LFTG  +PW
Sbjct: 101 GDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPW 160

Query: 216 KGLLLYGPPGTGKTLLAKAVATEC-KTTFFNISASTIVSKWRGDSEKLVRVLFELARYHA 274
           +G+LL+GPPGTGK+ LAKAVATE   +TFF++S+S ++SKW G+SEKLV+ LFELAR H 
Sbjct: 161 RGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHK 220

Query: 275 PSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWEL 334
           PS IF+DE++S+    G+ +  E E + R+KTE LVQM G+  + D   VL A+N+PW L
Sbjct: 221 PSIIFIDEVDSLC---GSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVL 277

Query: 335 DCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGS 394
           D A+ RR EKRI + LP   AR  M    L     +      T+     L+++TEGYSG+
Sbjct: 278 DSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNL-----TDANIHELARKTEGYSGA 332

Query: 395 DIKLVCREAAMRPVRKIFDA 414
           DI ++ R++ M+PVRK+  A
Sbjct: 333 DISIIVRDSLMQPVRKVQSA 352


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  223 bits (569), Expect = 2e-58
 Identities = 123/307 (40%), Positives = 192/307 (62%), Gaps = 24/307 (7%)

Query: 163 ELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYG 222
           ++  ++  +I  H P + W DI G++ AK  +KE VV+P+  P +FTG+  P KG+LL+G
Sbjct: 382 KMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFG 441

Query: 223 PPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDE 282
           PPGTGKTL+ K +A++   TFF+ISAS++ SKW G+ EK+VR LF +AR   P+ IF+DE
Sbjct: 442 PPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDE 501

Query: 283 LESVMSQRGTASGGEHEGSLRMKTELLVQMDG-LARSEDLVFVLAASNLPWELDCAMLRR 341
           ++S++SQRG    GEHE S R+KTE LVQ+DG    SED + V+ A+N P E+D A  RR
Sbjct: 502 IDSLLSQRG---DGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRR 558

Query: 342 LEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCR 401
           L KR+ + LP   AR+ ++ + +   SK +      E+E  V  Q+++ +SG+D+  +CR
Sbjct: 559 LVKRLYIPLPEASARKQIVINLM---SKEQCCLSEEEIEQIV--QQSDAFSGADMTQLCR 613

Query: 402 EAAMRPVRKIFDALENHQSESSDLPRI---QLDIVTTADFLDVLTHTKPSA--KNLAQRY 456
           EA++ P+R +         +++D+  I   Q+  +   DF +     +PS   K+L + Y
Sbjct: 614 EASLGPIRSL---------QTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDL-ELY 663

Query: 457 SDWQREF 463
            +W + F
Sbjct: 664 ENWNKTF 670


>gi|112789543 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  223 bits (569), Expect = 2e-58
 Identities = 123/307 (40%), Positives = 192/307 (62%), Gaps = 24/307 (7%)

Query: 163 ELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYG 222
           ++  ++  +I  H P + W DI G++ AK  +KE VV+P+  P +FTG+  P KG+LL+G
Sbjct: 382 KMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFG 441

Query: 223 PPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDE 282
           PPGTGKTL+ K +A++   TFF+ISAS++ SKW G+ EK+VR LF +AR   P+ IF+DE
Sbjct: 442 PPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDE 501

Query: 283 LESVMSQRGTASGGEHEGSLRMKTELLVQMDG-LARSEDLVFVLAASNLPWELDCAMLRR 341
           ++S++SQRG    GEHE S R+KTE LVQ+DG    SED + V+ A+N P E+D A  RR
Sbjct: 502 IDSLLSQRG---DGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRR 558

Query: 342 LEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCR 401
           L KR+ + LP   AR+ ++ + +   SK +      E+E  V  Q+++ +SG+D+  +CR
Sbjct: 559 LVKRLYIPLPEASARKQIVINLM---SKEQCCLSEEEIEQIV--QQSDAFSGADMTQLCR 613

Query: 402 EAAMRPVRKIFDALENHQSESSDLPRI---QLDIVTTADFLDVLTHTKPSA--KNLAQRY 456
           EA++ P+R +         +++D+  I   Q+  +   DF +     +PS   K+L + Y
Sbjct: 614 EASLGPIRSL---------QTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDL-ELY 663

Query: 457 SDWQREF 463
            +W + F
Sbjct: 664 ENWNKTF 670


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  215 bits (548), Expect = 6e-56
 Identities = 129/325 (39%), Positives = 199/325 (61%), Gaps = 19/325 (5%)

Query: 141 PDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVY 200
           P  + R  K L  F  ++S    LA ++  +I  +   +K++DI G D AKQ ++E V+ 
Sbjct: 272 PTTATRKKKDLKNFRNVDSN---LANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL 328

Query: 201 PIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSE 260
           P   P+LFTG+ +P +GLLL+GPPG GKT+LAKAVA E   TFFNISA+++ SK+ G+ E
Sbjct: 329 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 388

Query: 261 KLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGL-ARSE 319
           KLVR LF +AR   PS IF+DE++S++ +R     GEH+ S R+KTE L++ DG+ +  +
Sbjct: 389 KLVRALFAVARELQPSIIFIDEVDSLLCER---REGEHDASRRLKTEFLIEFDGVQSAGD 445

Query: 320 DLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTEL 379
           D V V+ A+N P ELD A+LRR  KR+ V LP+ E R  ++ + L            T+ 
Sbjct: 446 DRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPL-----TQK 500

Query: 380 EYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFL 439
           E + L++ T+GYSGSD+  + ++AA+ P+R++      + S +S++  I+L     +DF 
Sbjct: 501 ELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMS-ASEMRNIRL-----SDFT 554

Query: 440 DVLTHTKPS-AKNLAQRYSDWQREF 463
           + L   K S +    + Y  W ++F
Sbjct: 555 ESLKKIKRSVSPQTLEAYIRWNKDF 579


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score =  215 bits (548), Expect = 6e-56
 Identities = 129/325 (39%), Positives = 199/325 (61%), Gaps = 19/325 (5%)

Query: 141 PDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVY 200
           P  + R  K L  F  ++S    LA ++  +I  +   +K++DI G D AKQ ++E V+ 
Sbjct: 304 PTTATRKKKDLKNFRNVDSN---LANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL 360

Query: 201 PIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSE 260
           P   P+LFTG+ +P +GLLL+GPPG GKT+LAKAVA E   TFFNISA+++ SK+ G+ E
Sbjct: 361 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 420

Query: 261 KLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGL-ARSE 319
           KLVR LF +AR   PS IF+DE++S++ +R     GEH+ S R+KTE L++ DG+ +  +
Sbjct: 421 KLVRALFAVARELQPSIIFIDEVDSLLCER---REGEHDASRRLKTEFLIEFDGVQSAGD 477

Query: 320 DLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTEL 379
           D V V+ A+N P ELD A+LRR  KR+ V LP+ E R  ++ + L            T+ 
Sbjct: 478 DRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPL-----TQK 532

Query: 380 EYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFL 439
           E + L++ T+GYSGSD+  + ++AA+ P+R++      + S +S++  I+L     +DF 
Sbjct: 533 ELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMS-ASEMRNIRL-----SDFT 586

Query: 440 DVLTHTKPS-AKNLAQRYSDWQREF 463
           + L   K S +    + Y  W ++F
Sbjct: 587 ESLKKIKRSVSPQTLEAYIRWNKDF 611


>gi|64084766 fidgetin [Homo sapiens]
          Length = 759

 Score =  180 bits (457), Expect = 2e-45
 Identities = 119/385 (30%), Positives = 200/385 (51%), Gaps = 54/385 (14%)

Query: 88  SANFGLHISRIRKDSGEEN----AHPRRGQIIDFQGLLTDAIKGATSELALNTFDHNPDP 143
           S +FG + S +  + G+E+    +HP +G            ++ ATS       +H+ D 
Sbjct: 416 SESFGKYTSPVMSEHGDEHRQLLSHPMQGP----------GLRAATSS------NHSVDE 459

Query: 144 SERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIR 203
                        + +    L  +V+ +I    P + WNDI GLD  K ++KE V++P+ 
Sbjct: 460 Q------------LKNTDTHLIDLVTNEIITQGPPVDWNDIAGLDLVKAVIKEEVLWPVL 507

Query: 204 YPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLV 263
               F+G+ +  + +LL+GP GTGKTLL + +A++   TFF I+ S +V+KW G++EK++
Sbjct: 508 RSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAEKII 567

Query: 264 RVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDG-LARSEDLV 322
              F +AR   PS IF+ +++ ++S +      EH    RM+TE L+Q+D  L  +ED +
Sbjct: 568 HASFLVARCRQPSVIFVSDIDMLLSSQ---VNEEHSPVSRMRTEFLMQLDTVLTSAEDQI 624

Query: 323 FVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYS 382
            V+ A++ P E+D ++ R   KR+L+ LP   AR  +I   L     S+      + E++
Sbjct: 625 VVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQLL-----SQHNYCLNDKEFA 679

Query: 383 VLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRI---QLDIVTTADFL 439
           +L Q TEG+SG D+  +C+EA + P+         H   ++DL  I   QL  VT  DF 
Sbjct: 680 LLVQRTEGFSGLDVAHLCQEAVVGPL---------HAMPATDLSAIMPSQLRPVTYQDFE 730

Query: 440 DVLTHTKPS-AKNLAQRYSDWQREF 463
           +     +PS ++     Y +W + F
Sbjct: 731 NAFCKIQPSISQKELDMYVEWNKMF 755


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  171 bits (434), Expect = 1e-42
 Identities = 102/282 (36%), Positives = 159/282 (56%), Gaps = 22/282 (7%)

Query: 176 NPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTG--ILSPWKGLLLYGPPGTGKTLLAK 233
           N ++ W+DI GLD     +K+ V+ PI+   LF    +L P KG+LLYGPPG GKTL+AK
Sbjct: 85  NMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAK 144

Query: 234 AVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTA 293
           A A E    F N+  ST+  KW G+S+KL   +F LA    PS IF+DE++S +  R   
Sbjct: 145 ATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNR--- 201

Query: 294 SGGEHEGSLRMKTELLVQMDGLARSEDL-VFVLAASNLPWELDCAMLRRLEKRILVDLPS 352
           S  +HE +  MK + +   DGL       V V+ A+N P +LD A++RR+  R  ++ P+
Sbjct: 202 SSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPA 261

Query: 353 REARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIF 412
            + R+A+    L  + K+  ++ H +L    ++QET+G+SGSD+K +CR+AA+  VR+  
Sbjct: 262 LKQREAI----LKLILKNENVDRHVDL--LEVAQETDGFSGSDLKEMCRDAALLCVREYV 315

Query: 413 DALENHQSESSDLPRIQ----------LDIVTTADFLDVLTH 444
           ++      +  ++  +Q          +     A F +VLTH
Sbjct: 316 NSTSEESHDEDEIRPVQQQDLHRAIEKMKKSKDAAFQNVLTH 357


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  160 bits (406), Expect = 2e-39
 Identities = 93/262 (35%), Positives = 151/262 (57%), Gaps = 14/262 (5%)

Query: 170 RDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGK 228
           R+  +  P + W DI GL+  K+ ++E V YP+ +P  F    ++P KG+L YGPPG GK
Sbjct: 465 RETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGK 524

Query: 229 TLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMS 288
           TLLAKA+A EC+  F +I    +++ W G+SE  VR +F+ AR  AP  +F DEL+S+  
Sbjct: 525 TLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAK 584

Query: 289 QRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRI 346
            RG   G     + R+  ++L +MDG++  ++ VF++ A+N P  +D A+LR  RL++ I
Sbjct: 585 ARGGNIGDGGGAADRVINQILTEMDGMSTKKN-VFIIGATNRPDIIDPAILRPGRLDQLI 643

Query: 347 LVDLPSREARQAMIYHWL--PPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAA 404
            + LP  ++R A++   L   PV+K   LE         L++ T G+SG+D+  +C+ A 
Sbjct: 644 YIPLPDEKSRVAILKANLRKSPVAKDVDLEF--------LAKMTNGFSGADLTEICQRAC 695

Query: 405 MRPVRKIFDALENHQSESSDLP 426
              +R+  ++    + E    P
Sbjct: 696 KLAIRESIESEIRRERERQTNP 717



 Score =  149 bits (376), Expect = 5e-36
 Identities = 96/274 (35%), Positives = 156/274 (56%), Gaps = 14/274 (5%)

Query: 179 IKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVAT 237
           + ++DI G       +KE V  P+R+P LF  I + P +G+LLYGPPGTGKTL+A+AVA 
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260

Query: 238 ECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGE 297
           E    FF I+   I+SK  G+SE  +R  FE A  +AP+ IF+DEL+++  +R    G  
Sbjct: 261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHG-- 318

Query: 298 HEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPSREA 355
            E   R+ ++LL  MDGL +    V V+AA+N P  +D A+ R  R ++ + + +P    
Sbjct: 319 -EVERRIVSQLLTLMDGL-KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376

Query: 356 RQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDAL 415
           R  ++         ++ ++L  +++   ++ ET G+ G+D+  +C EAA++ +RK  D +
Sbjct: 377 RLEILQ------IHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLI 430

Query: 416 ENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSA 449
           +  + E+ D   +    VT  DF   L+ + PSA
Sbjct: 431 D-LEDETIDAEVMNSLAVTMDDFRWALSQSNPSA 463


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  160 bits (406), Expect = 2e-39
 Identities = 104/309 (33%), Positives = 174/309 (56%), Gaps = 34/309 (11%)

Query: 161 MRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLL 219
           M ++     R+I +  PN+ W+DI GL++ K  +++AV +P+++P+ F  + + P KG+L
Sbjct: 606 MNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVL 665

Query: 220 LYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIF 279
           LYGPPG  KT++AKA+A E    F  I    +++K+ G+SE+ VR  F  AR  APS IF
Sbjct: 666 LYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIF 725

Query: 280 LDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAML 339
            DEL+++  +RG++ G  +    R+  +LL +MDG+ + +D V +LAA+N P  +D A++
Sbjct: 726 FDELDALAVERGSSLGAGNVAD-RVLAQLLTEMDGIEQLKD-VTILAATNRPDRIDKALM 783

Query: 340 R--RLEKRILVDLPSREARQAMI---YHWLPPVSKSRALELHTELEYSVLSQETEGYSGS 394
           R  R+++ I V LP    R+ +    +H +P         +  E++   L  +T+ YSG+
Sbjct: 784 RPGRIDRIIYVPLPDAATRREIFKLQFHSMP---------VSNEVDLDELILQTDAYSGA 834

Query: 395 DIKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPS-AKNLA 453
           +I  VCREAA+        ALE           IQ +++    F   L+   P   ++L 
Sbjct: 835 EIVAVCREAALL-------ALEED---------IQANLIMKRHFTQALSTVTPRIPESLR 878

Query: 454 QRYSDWQRE 462
           + Y D+Q +
Sbjct: 879 RFYEDYQEK 887



 Score =  144 bits (363), Expect = 2e-34
 Identities = 97/277 (35%), Positives = 151/277 (54%), Gaps = 19/277 (6%)

Query: 179 IKWNDIIGLDAAKQLVKEAVVYPIRYPQLFT--GILSPWKGLLLYGPPGTGKTLLAKAVA 236
           + ++ I GL +  + ++E +  P++ P+LF   GI +P +G+LLYGPPGTGKT++A+AVA
Sbjct: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAP-RGVLLYGPPGTGKTMIARAVA 408

Query: 237 TECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGG 296
            E       I+   I+SK+ G++E  +R +F  A    PS IF+DEL+++  +R    G 
Sbjct: 409 NEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR---EGA 465

Query: 297 EHEGSLRMKTELLVQMDGLAR--SEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPS 352
           ++E   R+   LL  MDG+    SE  V VL A+N P  LD A+ R  R +K I + +P+
Sbjct: 466 QNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPN 525

Query: 353 REARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIF 412
            + R  ++   L      R   L TE E   L+    GY G+D+K++C EA +  +R+I 
Sbjct: 526 AQDRLDILQKLL-----RRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRIL 580

Query: 413 DALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSA 449
                 Q    D+    L  +T  DFL  +   +PSA
Sbjct: 581 ----KKQPNLPDVKVAGLVKITLKDFLQAMNDIRPSA 613


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  155 bits (391), Expect = 1e-37
 Identities = 95/275 (34%), Positives = 157/275 (57%), Gaps = 12/275 (4%)

Query: 143 PSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPI 202
           P  R+   ++    M    RE+  +V    +    N+ +++I GL    + ++E +  P+
Sbjct: 108 PGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPL 167

Query: 203 RYPQLF--TGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSE 260
             P+LF   GI+ P KG LLYGPPGTGKTLLA+AVA++    F  + +S+IV K+ G+S 
Sbjct: 168 TNPELFQRVGIIPP-KGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESA 226

Query: 261 KLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSED 320
           +L+R +F  AR H P  IF+DE++++  +R +          R   ELL QMDG      
Sbjct: 227 RLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHR 286

Query: 321 LVFVLAASNLPWELDCAMLR--RLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTE 378
           +  ++ A+N P  LD A+LR  RL+++I +DLP+ +AR  ++     P++K      H E
Sbjct: 287 VKMIM-ATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITK------HGE 339

Query: 379 LEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFD 413
           ++Y  + + ++G++G+D++ VC EA M  +R   D
Sbjct: 340 IDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHD 374


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  145 bits (367), Expect = 6e-35
 Identities = 90/238 (37%), Positives = 139/238 (58%), Gaps = 12/238 (5%)

Query: 177 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFT--GILSPWKGLLLYGPPGTGKTLLAKA 234
           P+  +  I GLD   + +KE +  P+++P+LF   GI  P KG+LLYGPPGTGKTLLA+A
Sbjct: 144 PDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQP-KGVLLYGPPGTGKTLLARA 202

Query: 235 VATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTAS 294
           VA     TF  +S S +V K+ G+  ++VR LF +AR HAPS IF+DE++S+ S R    
Sbjct: 203 VAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGG 262

Query: 295 GGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPS 352
            G      R   ELL Q+DG   ++++  ++A + +   LD A+LR  R++++I    P+
Sbjct: 263 SGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRID-ILDSALLRPGRIDRKIEFPPPN 321

Query: 353 REARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 410
            EAR  ++         SR + L   +    +++   G SG+++K VC EA M  +R+
Sbjct: 322 EEARLDIL------KIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRE 373


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  145 bits (365), Expect = 1e-34
 Identities = 105/293 (35%), Positives = 161/293 (54%), Gaps = 21/293 (7%)

Query: 177 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVA 236
           P++ W+D+ GL   K+ + E +  P+ +P+L +  L    GLLL+GPPGTGKTLLAKAVA
Sbjct: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRR-SGLLLHGPPGTGKTLLAKAVA 758

Query: 237 TECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTA--S 294
           TEC  TF ++    +++ + G SE+ VR +F  AR  AP  IF DEL+S+   RG +  S
Sbjct: 759 TECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDS 818

Query: 295 GGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPS 352
           GG  +   R+ ++LL ++DGL  ++D VFV+ A+N P  LD A+LR  R +K + V    
Sbjct: 819 GGVMD---RVVSQLLAELDGLHSTQD-VFVIGATNRPDLLDPALLRPGRFDKLVFVGANE 874

Query: 353 REARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPV-RKI 411
             A Q  +   L  +++   LE    L  +VL       +G+D+  +C +A    + R++
Sbjct: 875 DRASQLRV---LSAITRKFKLEPSVSL-VNVLDCCPPQLTGADLYSLCSDAMTAALKRRV 930

Query: 412 FDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPS-AKNLAQRYSDWQREF 463
            D  E  +  SS L      ++T  D L      +PS ++    RY   QR+F
Sbjct: 931 HDLEEGLEPGSSAL------MLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 46/197 (23%), Positives = 81/197 (41%), Gaps = 17/197 (8%)

Query: 205 PQLFTG--ILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKL 262
           P+L  G  +L+    +LL GPPG GKT +  A  +        +  S++ ++  G  E  
Sbjct: 451 PRLQPGGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETK 510

Query: 263 VRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLV 322
           ++ +F  AR   P+ + L  ++ +   R     GE    + +   LL+  D L     L+
Sbjct: 511 LQAIFSRARRCRPAVLLLTAVDLLGRDRDGL--GEDARVMAVLRHLLLNEDPLNSCPPLM 568

Query: 323 FVLA---ASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTEL 379
            V     A +LP ++  A    LE   L +       +A+  H          L L  E+
Sbjct: 569 VVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAH----------LPLGQEV 618

Query: 380 EYSVLSQETEGYSGSDI 396
             + L++   G+   D+
Sbjct: 619 NLAQLARRCAGFVVGDL 635


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  143 bits (361), Expect = 3e-34
 Identities = 87/237 (36%), Positives = 137/237 (57%), Gaps = 10/237 (4%)

Query: 177 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAV 235
           P   + DI GLD   Q +KE+V  P+ +P+ +  + + P KG++LYGPPGTGKTLLAKAV
Sbjct: 180 PQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAV 239

Query: 236 ATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASG 295
           A +   TF  +  S ++ K+ GD  KLVR LF +A  HAPS +F+DE++++ ++R  ++ 
Sbjct: 240 ANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNS 299

Query: 296 GEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPSR 353
           G      R   ELL Q+DG     D V V+ A+N    LD A++R  R++++I   LP  
Sbjct: 300 GGEREIQRTMLELLNQLDGFDSRGD-VKVIMATNRIETLDPALIRPGRIDRKIEFPLPDE 358

Query: 354 EARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 410
           + ++ +       +  SR + L  ++    L    +  SG+DIK +C EA +  +R+
Sbjct: 359 KTKKRIF-----QIHTSR-MTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRE 409


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  142 bits (358), Expect = 6e-34
 Identities = 89/237 (37%), Positives = 139/237 (58%), Gaps = 10/237 (4%)

Query: 177 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAV 235
           P  +++DI GLD   Q + EA+V P+ + + F  + + P KG+L+YGPPGTGKTLLA+A 
Sbjct: 181 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 240

Query: 236 ATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASG 295
           A + K TF  ++   +V  + GD  KLVR  F LA+  APS IF+DEL+++ ++R  +  
Sbjct: 241 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 300

Query: 296 GEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPSR 353
                  R   ELL Q+DG  +    V V+AA+N    LD A+LR  RL+++I   +P+ 
Sbjct: 301 AGDREVQRTMLELLNQLDGF-QPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNE 359

Query: 354 EARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 410
           EAR  ++         SR + +  ++ Y  L++ T+ ++G+  K VC EA M  +R+
Sbjct: 360 EARARIMQ------IHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRR 410


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  137 bits (345), Expect = 2e-32
 Identities = 85/237 (35%), Positives = 140/237 (59%), Gaps = 10/237 (4%)

Query: 177 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAV 235
           P++ + DI G+D  KQ V+EAV  P+ + +L+  I + P +G+L+YGPPG GKT+LAKAV
Sbjct: 156 PDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAV 215

Query: 236 ATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASG 295
           A      F  +  S  V K+ G+  ++VR +F LA+ +AP+ IF+DE++++ ++R  A  
Sbjct: 216 AHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQT 275

Query: 296 GEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPSR 353
           G      R+  ELL QMDG  ++ + V V+ A+N    LD A+LR  RL+++I   LP R
Sbjct: 276 GADREVQRILLELLNQMDGFDQNVN-VKVIMATNRADTLDPALLRPGRLDRKIEFPLPDR 334

Query: 354 EARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 410
             ++ +I+  +     +  + L  E++        +  SG+DI  +C+E+ M  VR+
Sbjct: 335 RQKR-LIFSTI-----TSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRE 385


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  137 bits (345), Expect = 2e-32
 Identities = 85/237 (35%), Positives = 140/237 (59%), Gaps = 10/237 (4%)

Query: 177 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAV 235
           P++ + DI G+D  KQ V+EAV  P+ + +L+  I + P +G+L+YGPPG GKT+LAKAV
Sbjct: 129 PDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAV 188

Query: 236 ATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASG 295
           A      F  +  S  V K+ G+  ++VR +F LA+ +AP+ IF+DE++++ ++R  A  
Sbjct: 189 AHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQT 248

Query: 296 GEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPSR 353
           G      R+  ELL QMDG  ++ + V V+ A+N    LD A+LR  RL+++I   LP R
Sbjct: 249 GADREVQRILLELLNQMDGFDQNVN-VKVIMATNRADTLDPALLRPGRLDRKIEFPLPDR 307

Query: 354 EARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 410
             ++ +I+  +     +  + L  E++        +  SG+DI  +C+E+ M  VR+
Sbjct: 308 RQKR-LIFSTI-----TSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRE 358


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  137 bits (345), Expect = 2e-32
 Identities = 85/237 (35%), Positives = 140/237 (59%), Gaps = 10/237 (4%)

Query: 177 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAV 235
           P++ + DI G+D  KQ V+EAV  P+ + +L+  I + P +G+L+YGPPG GKT+LAKAV
Sbjct: 160 PDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAV 219

Query: 236 ATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASG 295
           A      F  +  S  V K+ G+  ++VR +F LA+ +AP+ IF+DE++++ ++R  A  
Sbjct: 220 AHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQT 279

Query: 296 GEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPSR 353
           G      R+  ELL QMDG  ++ + V V+ A+N    LD A+LR  RL+++I   LP R
Sbjct: 280 GADREVQRILLELLNQMDGFDQNVN-VKVIMATNRADTLDPALLRPGRLDRKIEFPLPDR 338

Query: 354 EARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 410
             ++ +I+  +     +  + L  E++        +  SG+DI  +C+E+ M  VR+
Sbjct: 339 RQKR-LIFSTI-----TSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRE 389


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  133 bits (334), Expect = 4e-31
 Identities = 91/289 (31%), Positives = 156/289 (53%), Gaps = 35/289 (12%)

Query: 178 NIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVA 236
           +++++ I GL      +KE VV+P+ YP++F    + P +G L YGPPGTGKTL+A+A+A
Sbjct: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455

Query: 237 TEC-----KTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRG 291
            EC     K  FF    +  +SKW G+SE+ +R+LF+ A    PS IF DE++ +   R 
Sbjct: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515

Query: 292 TASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVD 349
           +     H     + + LL  MDGL    ++V V+ A+N    +D A+ R  R ++  L +
Sbjct: 516 SRQDQIHSS---IVSTLLALMDGLDNRGEIV-VIGATNRLDSIDPALRRPGRFDREFLFN 571

Query: 350 LPSREARQAMIY----HWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAM 405
           LP ++AR+ ++      W P +S +   E         L+++  GY G+DIK +C EAA+
Sbjct: 572 LPDQKARKHILQIHTRDWNPKLSDAFLGE---------LAEKCVGYCGADIKALCTEAAL 622

Query: 406 RPVRKIFDALENHQSESSDLPRIQLD----IVTTADFLDVLTHTKPSAK 450
             +R+ +  +       +   ++QLD    +++  DF   + +  P+++
Sbjct: 623 IALRRRYPQI------YASSHKLQLDVSSIVLSAQDFYHAMQNIVPASQ 665


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  131 bits (330), Expect = 1e-30
 Identities = 87/248 (35%), Positives = 144/248 (58%), Gaps = 16/248 (6%)

Query: 170 RDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFT--GILSPWKGLLLYGPPGTG 227
           R+ ++  PN+ W DI  L+  ++ +  A++ P+R P  F   G+++P  G+LL GPPG G
Sbjct: 463 REGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCG 521

Query: 228 KTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVM 287
           KTLLAKAVA E    F ++    +++ + G+SE+ VR +F+ A+  AP  IF DE++++ 
Sbjct: 522 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC 581

Query: 288 SQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKR 345
            +R   S  E   S+R+  +LL +MDGL  +   VF++AA+N P  +D A+LR  RL+K 
Sbjct: 582 PRR---SDRETGASVRVVNQLLTEMDGL-EARQQVFIMAATNRPDIIDPAILRPGRLDKT 637

Query: 346 ILVDLPSREARQAMIYHWLPPVSKSRA---LELHTELEYSVLSQETEGYSGSDIKLVCRE 402
           + V LP    R A+    L  ++K+     L+    LE        + Y+G+D+  + RE
Sbjct: 638 LFVGLPPPADRLAI----LKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVRE 693

Query: 403 AAMRPVRK 410
           A++  +R+
Sbjct: 694 ASICALRQ 701



 Score =  127 bits (318), Expect = 3e-29
 Identities = 88/267 (32%), Positives = 147/267 (55%), Gaps = 20/267 (7%)

Query: 169 SRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLF--TGILSPWKGLLLYGPPGT 226
           +R +     N+K+ D+ G D   + V + +++ +R+P+++   G++ P +G+LL+GPPG 
Sbjct: 146 ARGLEFQISNVKFEDVGGNDMTLKEVCKMLIH-MRHPEVYHHLGVVPP-RGVLLHGPPGC 203

Query: 227 GKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESV 286
           GKTLLA A+A E       ++A  IVS   G+SE+ +R LFE A  +AP  IF+DE++++
Sbjct: 204 GKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAI 263

Query: 287 MSQRGTASGGEHEGSLRMKTELLVQMDGL--ARSEDLVFVLAASNLPWELDCAMLR--RL 342
             +R  AS    +   R+  +LL  MD L    +   V V+ A+N P  LD A+ R  R 
Sbjct: 264 TPKREVAS---KDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRF 320

Query: 343 EKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCRE 402
           ++ I + +P   +R+ ++       +  R L L    ++  L+  T G+ G+D+  +CRE
Sbjct: 321 DREICLGIPDEASRERILQ------TLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCRE 374

Query: 403 AAMRPVRKIFDALENHQS---ESSDLP 426
           AAM  V ++   L+  Q    E  DLP
Sbjct: 375 AAMCAVNRVLMKLQEQQKKNPEMEDLP 401


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  131 bits (330), Expect = 1e-30
 Identities = 87/248 (35%), Positives = 144/248 (58%), Gaps = 16/248 (6%)

Query: 170 RDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFT--GILSPWKGLLLYGPPGTG 227
           R+ ++  PN+ W DI  L+  ++ +  A++ P+R P  F   G+++P  G+LL GPPG G
Sbjct: 569 REGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCG 627

Query: 228 KTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVM 287
           KTLLAKAVA E    F ++    +++ + G+SE+ VR +F+ A+  AP  IF DE++++ 
Sbjct: 628 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC 687

Query: 288 SQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKR 345
            +R   S  E   S+R+  +LL +MDGL  +   VF++AA+N P  +D A+LR  RL+K 
Sbjct: 688 PRR---SDRETGASVRVVNQLLTEMDGL-EARQQVFIMAATNRPDIIDPAILRPGRLDKT 743

Query: 346 ILVDLPSREARQAMIYHWLPPVSKSRA---LELHTELEYSVLSQETEGYSGSDIKLVCRE 402
           + V LP    R A+    L  ++K+     L+    LE        + Y+G+D+  + RE
Sbjct: 744 LFVGLPPPADRLAI----LKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVRE 799

Query: 403 AAMRPVRK 410
           A++  +R+
Sbjct: 800 ASICALRQ 807



 Score =  127 bits (318), Expect = 3e-29
 Identities = 88/267 (32%), Positives = 147/267 (55%), Gaps = 20/267 (7%)

Query: 169 SRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLF--TGILSPWKGLLLYGPPGT 226
           +R +     N+K+ D+ G D   + V + +++ +R+P+++   G++ P +G+LL+GPPG 
Sbjct: 252 ARGLEFQISNVKFEDVGGNDMTLKEVCKMLIH-MRHPEVYHHLGVVPP-RGVLLHGPPGC 309

Query: 227 GKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESV 286
           GKTLLA A+A E       ++A  IVS   G+SE+ +R LFE A  +AP  IF+DE++++
Sbjct: 310 GKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAI 369

Query: 287 MSQRGTASGGEHEGSLRMKTELLVQMDGL--ARSEDLVFVLAASNLPWELDCAMLR--RL 342
             +R  AS    +   R+  +LL  MD L    +   V V+ A+N P  LD A+ R  R 
Sbjct: 370 TPKREVAS---KDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRF 426

Query: 343 EKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCRE 402
           ++ I + +P   +R+ ++       +  R L L    ++  L+  T G+ G+D+  +CRE
Sbjct: 427 DREICLGIPDEASRERILQ------TLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCRE 480

Query: 403 AAMRPVRKIFDALENHQS---ESSDLP 426
           AAM  V ++   L+  Q    E  DLP
Sbjct: 481 AAMCAVNRVLMKLQEQQKKNPEMEDLP 507


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  129 bits (324), Expect = 6e-30
 Identities = 86/245 (35%), Positives = 135/245 (55%), Gaps = 25/245 (10%)

Query: 178 NIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVA 236
           +++++ + GL      +KE VV+P+ YP++F    + P +G L YGPPGTGKTL+A+A+A
Sbjct: 422 SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALA 481

Query: 237 TEC-----KTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRG 291
            EC     +  FF    +  +SKW G+SE+ +R+LF+ A    PS IF DE++ +   R 
Sbjct: 482 NECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRS 541

Query: 292 TASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVD 349
           +     H     + + LL  MDGL    ++V V+ A+N    +D A+ R  R ++  L  
Sbjct: 542 SRQDQIHSS---IVSTLLALMDGLDSRGEIV-VIGATNRLDSIDPALRRPGRFDREFLFS 597

Query: 350 LPSREARQAMI----YHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAM 405
           LP +EAR+ ++      W P         L T LE   L++   GY G+DIK +C EAA+
Sbjct: 598 LPDKEARKEILKIHTRDWNPK-------PLDTFLE--ELAENCVGYCGADIKSICAEAAL 648

Query: 406 RPVRK 410
             +R+
Sbjct: 649 CALRR 653


>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
          Length = 797

 Score =  128 bits (321), Expect = 1e-29
 Identities = 90/255 (35%), Positives = 138/255 (54%), Gaps = 19/255 (7%)

Query: 178 NIKWNDIIGLDAAKQLVKEAVVY---PIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKA 234
           ++K+ D+ G + AK  + E V +   P +Y  L  G   P KG +L GPPGTGKTLLAKA
Sbjct: 304 DVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDL--GAKIP-KGAILTGPPGTGKTLLAKA 360

Query: 235 VATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTAS 294
            A E    F  +S S  +  + G     VR LF LAR +AP  +F+DE+++V  +RG  +
Sbjct: 361 TAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGN 420

Query: 295 GGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPS 352
            G          +LLV+MDG   + ++V +LA +N P  LD A+LR  R +++I +  P 
Sbjct: 421 FGGQSEQENTLNQLLVEMDGFNTTTNVV-ILAGTNRPDILDPALLRPGRFDRQIFIGPPD 479

Query: 353 REARQAMIYHWLPPVSKSRALELHTELEYSVLSQE----TEGYSGSDIKLVCREAAMRPV 408
            + R ++    L P      L+L + LE   L+++    T G+SG+D+  VC EAA+   
Sbjct: 480 IKGRASIFKVHLRP------LKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAA 533

Query: 409 RKIFDALENHQSESS 423
           R + D++     E +
Sbjct: 534 RHLSDSINQKHFEQA 548


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  127 bits (318), Expect = 3e-29
 Identities = 94/317 (29%), Positives = 164/317 (51%), Gaps = 27/317 (8%)

Query: 116  DFQGLLTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLH 175
            DF  L+  AI    S  +++T +          K +   +     +R       R + LH
Sbjct: 783  DFTVLVDRAIHSRLSRQSISTRE----------KLVLTTLDFQKALRGFLPASLRSVNLH 832

Query: 176  NP-NIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAK 233
             P ++ W+ I GL   +Q++ + +  P +YP+LF  + +    G+LLYGPPGTGKTLLA 
Sbjct: 833  KPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAG 892

Query: 234  AVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTA 293
             +A E +  F ++    ++SK+ G SE+ VR +F  A+   P  +F DE ES+  +RG  
Sbjct: 893  VIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHD 952

Query: 294  SGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLP 351
            + G  +   R+  +LL Q+DG+   +  V+VLAA++ P  +D A+LR  RL+K +    P
Sbjct: 953  NTGVTD---RVVNQLLTQLDGVEGLQG-VYVLAATSRPDLIDPALLRPGRLDKCVYCPPP 1008

Query: 352  SREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKI 411
             + +R  ++         S +L L  +++   ++  T+ ++G+D+K +   A +  +  +
Sbjct: 1009 DQVSRLEILN------VLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGM 1062

Query: 412  F--DALENHQSES-SDL 425
                 L++  S S SDL
Sbjct: 1063 LLSSGLQDGSSSSDSDL 1079



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 60/253 (23%), Positives = 105/253 (41%), Gaps = 43/253 (16%)

Query: 218 LLLYGPPGTGKTLLAKAVATECKTTFFNISA-------STIVSKWRGDSEKLVRVLFELA 270
           LLL G  G+GK+ LAKA+   CK  F  + A         +  K   + +K + V F  A
Sbjct: 595 LLLTGGKGSGKSTLAKAI---CKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEA 651

Query: 271 RYHAPSTIFLDELESVMSQRGTASGGEHE------GSLRMKTELLVQMDGLARSEDLVFV 324
            +  PS + LD+L+ +    G  +  EHE       S R+   L   +        LV +
Sbjct: 652 VWMQPSVVLLDDLDLI---AGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVAL 708

Query: 325 LAASNLPWELDCAMLRRLEKRIL-----VDLPSREARQAMIYHWLPPVSKSRA---LELH 376
           +A S     L   ++      I      +  P++E R  ++ +    V K++    +   
Sbjct: 709 IATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCN----VIKNKLDCDINKF 764

Query: 377 TELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTA 436
           T+L+   +++ET G+   D  ++           +  A+ +  S  S   R +L ++TT 
Sbjct: 765 TDLDLQHVAKETGGFVARDFTVL-----------VDRAIHSRLSRQSISTREKL-VLTTL 812

Query: 437 DFLDVLTHTKPSA 449
           DF   L    P++
Sbjct: 813 DFQKALRGFLPAS 825


>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
          Length = 795

 Score =  127 bits (318), Expect = 3e-29
 Identities = 89/241 (36%), Positives = 137/241 (56%), Gaps = 20/241 (8%)

Query: 179 IKWNDIIGLDAAKQLVKEAVVY---PIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAV 235
           + + D+ G+  AK  V+E V Y   P R+ QL  G   P KG LL GPPG GKTLLAKAV
Sbjct: 306 VSFKDVAGMHEAKLEVREFVDYLKSPERFLQL--GAKVP-KGALLLGPPGCGKTLLAKAV 362

Query: 236 ATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASG 295
           ATE +  F  ++    V    G     VR LF+ AR  AP  +++DE+++V  +R T   
Sbjct: 363 ATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMS 422

Query: 296 G----EHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVD 349
           G    E E +L    +LLV+MDG+  + D V VLA++N    LD A++R  RL++ + +D
Sbjct: 423 GFSNTEEEQTL---NQLLVEMDGMG-TTDHVIVLASTNRADILDGALMRPGRLDRHVFID 478

Query: 350 LPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVR 409
           LP+ + R+ +    L  +  +++   +++     L++ T G+SG+DI  +C EAA+   R
Sbjct: 479 LPTLQERREIFEQHLKSLKLTQSSTFYSQR----LAELTPGFSGADIANICNEAALHAAR 534

Query: 410 K 410
           +
Sbjct: 535 E 535


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  125 bits (315), Expect = 6e-29
 Identities = 78/237 (32%), Positives = 134/237 (56%), Gaps = 12/237 (5%)

Query: 177 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAV 235
           P++ ++D+ G     + ++E V  P+ +P+ F  + + P KG+LL+GPPGTGKTL A+AV
Sbjct: 170 PDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAV 229

Query: 236 ATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQR-GTAS 294
           A      F  +  S +V K+ G+  ++VR LFE+AR      IF DE++++   R    +
Sbjct: 230 ANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGA 289

Query: 295 GGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPS 352
           GG++E   R   EL+ Q+DG     + + VL A+N P  LD A++R  RL+++I   LP 
Sbjct: 290 GGDNEVQ-RTMLELINQLDGFDPRGN-IKVLMATNRPDTLDPALMRPGRLDRKIEFSLPD 347

Query: 353 REARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVR 409
            E R  +          +R++ +  ++ + +L++     +G++I+ VC EA M  +R
Sbjct: 348 LEGRTHIF------KIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIR 398


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,674,656
Number of Sequences: 37866
Number of extensions: 692428
Number of successful extensions: 2229
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2042
Number of HSP's gapped (non-prelim): 101
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.