Search of human proteins with 21361144

Search of human proteins with 21361144

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
         (439 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            860   0.0  
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            346   2e-95
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            317   1e-86
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   316   2e-86
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]   316   2e-86
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   309   4e-84
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             296   3e-80
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           283   2e-76
gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]          280   1e-75
gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]          280   1e-75
gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo sap...   280   1e-75
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              200   2e-51
gi|6005942 valosin-containing protein [Homo sapiens]                  196   4e-50
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]            188   7e-48
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 172   5e-43
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 172   5e-43
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     169   4e-42
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       168   1e-41
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           168   1e-41
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]              165   7e-41
gi|4505725 peroxin1 [Homo sapiens]                                    165   9e-41
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   163   3e-40
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                      160   2e-39
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                       160   2e-39
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               156   3e-38
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               156   3e-38
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     155   7e-38
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     146   4e-35
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]              142   6e-34
gi|40806170 spastin isoform 2 [Homo sapiens]                          142   8e-34

>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  860 bits (2222), Expect = 0.0
 Identities = 439/439 (100%), Positives = 439/439 (100%)

Query: 1   MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL 60
           MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL
Sbjct: 1   MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL 60

Query: 61  RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK 120
           RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK
Sbjct: 61  RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK 120

Query: 121 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER 180
           CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER
Sbjct: 121 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER 180

Query: 181 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 240
           PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC
Sbjct: 181 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 240

Query: 241 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 300
           AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK
Sbjct: 241 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 300

Query: 301 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE 360
           AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE
Sbjct: 301 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE 360

Query: 361 ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY 420
           ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY
Sbjct: 361 ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY 420

Query: 421 MEGILEVQAKKKANLQYYA 439
           MEGILEVQAKKKANLQYYA
Sbjct: 421 MEGILEVQAKKKANLQYYA 439


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  346 bits (888), Expect = 2e-95
 Identities = 171/379 (45%), Positives = 253/379 (66%), Gaps = 20/379 (5%)

Query: 54  IMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDL 113
           +M+ E +R   +++ +++K +E   K+   +  P  V  + E++D +             
Sbjct: 73  LMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNH------------ 120

Query: 114 DSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVK 173
                   A++ TS    +++ ++  VD + L+PG  V +N   + ++  L  + D  V 
Sbjct: 121 --------AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVT 172

Query: 174 AMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGK 233
            M+V++ P E Y+DIGGLD QIQE+ E++ LP+ H E +E +GI+PPKGV++YGPPGTGK
Sbjct: 173 VMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGK 232

Query: 234 TLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGT 293
           TLLA+A A QT ATFL++ G +L+Q ++GDG KLVR+ F +A+E APSI+FIDE+DAIGT
Sbjct: 233 TLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGT 292

Query: 294 KRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIE 353
           KR+DS   G+RE+QRTMLELLNQLDGF     VKVI ATNR++ LDPAL+R GR+DRKIE
Sbjct: 293 KRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIE 352

Query: 354 FPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGAT 413
           FP+P+E+ + RI QIH+ +M ++ DV  ++L    DD +GA  KA+C EAG++ALR    
Sbjct: 353 FPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRM 412

Query: 414 ELTHEDYMEGILEVQAKKK 432
           ++T+ED+ +    V  KK+
Sbjct: 413 KVTNEDFKKSKENVLYKKQ 431


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  317 bits (812), Expect = 1e-86
 Identities = 170/377 (45%), Positives = 237/377 (62%), Gaps = 4/377 (1%)

Query: 55  MKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANI-DL 113
           ++   L    ELQ + +   +N  +++  +     ++  + LL  +    +E G+ + ++
Sbjct: 20  LRQYYLSKIEELQLIVNDKSQNLRRLQAQRNE---LNAKVRLLREELQLLQEQGSYVGEV 76

Query: 114 DSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVK 173
                 K  ++K      + + V   +D   + P   V +  DSY + + LP + D  V 
Sbjct: 77  VRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVS 136

Query: 174 AMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGK 233
            M V++ P   Y  IGGLDKQI+E+ E I LP+ H E FE LGI  PKGVL+YGPPGTGK
Sbjct: 137 LMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGK 196

Query: 234 TLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGT 293
           TLLARA A  T  TF++++G +LVQ FIG+GA++VR+ F +A+E APSIIF+DE+D+IG+
Sbjct: 197 TLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGS 256

Query: 294 KRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIE 353
            R +    GD EVQRTMLELLNQLDGF+    +KVI ATNR+DILD ALLR GR+DRKIE
Sbjct: 257 SRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIE 316

Query: 354 FPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGAT 413
           FP PNEEAR  I++IHSRKMN++  +N  ++A      +GA+ K VC EAGM ALR    
Sbjct: 317 FPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRV 376

Query: 414 ELTHEDYMEGILEVQAK 430
            +T ED+   + +V  K
Sbjct: 377 HVTQEDFEMAVAKVMQK 393


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  316 bits (810), Expect = 2e-86
 Identities = 159/400 (39%), Positives = 246/400 (61%), Gaps = 20/400 (5%)

Query: 39  EEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLD 98
           E++  R + L  E++ ++ +   +  E + +K +     E++K  +++P ++   +E +D
Sbjct: 34  EDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVD 93

Query: 99  VDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSY 158
            +                     A++ ++T   Y++ ++  +D E LKP   V ++K S 
Sbjct: 94  QNT--------------------AIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSN 133

Query: 159 LILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQ 218
            +++ LP E DS +  +  D++P   Y+DIGG+D Q QE+ EA+ LP+ H E ++ +GI 
Sbjct: 134 ALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGID 193

Query: 219 PPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEK 278
           PP+GVLMYGPPG GKT+LA+A A  T A F+++ G + VQ ++G+G ++VRD F LAKE 
Sbjct: 194 PPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKEN 253

Query: 279 APSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDIL 338
           AP+IIFIDE+DAI TKRFD++   DREVQR +LELLNQ+DGF  N  VKVI ATNR D L
Sbjct: 254 APAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTL 313

Query: 339 DPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKA 398
           DPALLR GRLDRKIEFP+P+   +  I    + KMN+S +V+ E+     D  +GA   +
Sbjct: 314 DPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINS 373

Query: 399 VCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYY 438
           +C E+GM+A+R     +  +D+ +    V  K +   ++Y
Sbjct: 374 ICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFY 413


>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
          Length = 418

 Score =  316 bits (810), Expect = 2e-86
 Identities = 159/400 (39%), Positives = 246/400 (61%), Gaps = 20/400 (5%)

Query: 39  EEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLD 98
           E++  R + L  E++ ++ +   +  E + +K +     E++K  +++P ++   +E +D
Sbjct: 38  EDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVD 97

Query: 99  VDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSY 158
            +                     A++ ++T   Y++ ++  +D E LKP   V ++K S 
Sbjct: 98  QNT--------------------AIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSN 137

Query: 159 LILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQ 218
            +++ LP E DS +  +  D++P   Y+DIGG+D Q QE+ EA+ LP+ H E ++ +GI 
Sbjct: 138 ALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGID 197

Query: 219 PPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEK 278
           PP+GVLMYGPPG GKT+LA+A A  T A F+++ G + VQ ++G+G ++VRD F LAKE 
Sbjct: 198 PPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKEN 257

Query: 279 APSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDIL 338
           AP+IIFIDE+DAI TKRFD++   DREVQR +LELLNQ+DGF  N  VKVI ATNR D L
Sbjct: 258 APAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTL 317

Query: 339 DPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKA 398
           DPALLR GRLDRKIEFP+P+   +  I    + KMN+S +V+ E+     D  +GA   +
Sbjct: 318 DPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINS 377

Query: 399 VCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYY 438
           +C E+GM+A+R     +  +D+ +    V  K +   ++Y
Sbjct: 378 ICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFY 417


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  309 bits (791), Expect = 4e-84
 Identities = 155/374 (41%), Positives = 233/374 (62%), Gaps = 20/374 (5%)

Query: 65  ELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVI 124
           E + ++D      E++K  +++P ++   +E +D +                     A++
Sbjct: 33  EPEDLEDLYSRYKEEVKRIQSIPLVIGQFLEAVDQNT--------------------AIV 72

Query: 125 KTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQ 184
            ++T   Y++ ++  +D E LKP   V ++K S  +++ LP E DS +  +  D++P   
Sbjct: 73  GSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVM 132

Query: 185 YSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQT 244
           Y+DIGG+D Q QE+ EA+ LP+ H E ++ +GI PP+GVLMYGPPG GKT+LA+A A  T
Sbjct: 133 YADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHT 192

Query: 245 KATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDR 304
            A F+++ G + VQ ++G+G ++VRD F LAKE AP+IIFIDE+DAI TKRFD++   DR
Sbjct: 193 TAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADR 252

Query: 305 EVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARAR 364
           EVQR +LELLNQ+DGF  N  VKVI ATNR D LDPALLR GRLDRKIEFP+P+   +  
Sbjct: 253 EVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRL 312

Query: 365 IMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGI 424
           I    + KMN+S +V+ E+     D  +GA   ++C E+GM+A+R     +  +D+ +  
Sbjct: 313 IFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAY 372

Query: 425 LEVQAKKKANLQYY 438
             V  K +   ++Y
Sbjct: 373 KTVIKKDEQEHEFY 386


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  296 bits (757), Expect = 3e-80
 Identities = 144/283 (50%), Positives = 199/283 (70%)

Query: 145 LKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVL 204
           ++ G  VGV+++ Y I   LP + D  V  M+V+E+P   YSD+GG  +QI++L E +  
Sbjct: 134 IEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVET 193

Query: 205 PMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDG 264
           P+ H E+F NLGI+PPKGVL++GPPGTGKTL ARA A +T A F+++ G +LVQ ++G+G
Sbjct: 194 PLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEG 253

Query: 265 AKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNT 324
           A++VR+ F +A+ K   +IF DE+DAIG  RFD    GD EVQRTMLEL+NQLDGF P  
Sbjct: 254 ARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRG 313

Query: 325 QVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEEL 384
            +KV+ ATNR D LDPAL+R GRLDRKIEF +P+ E R  I +IH+R M+V  D+ +E L
Sbjct: 314 NIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELL 373

Query: 385 ARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEV 427
           AR   +  GA+ ++VC EAGM A+R      T +D++E + +V
Sbjct: 374 ARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKV 416


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  283 bits (724), Expect = 2e-76
 Identities = 143/310 (46%), Positives = 201/310 (64%)

Query: 123 VIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPT 182
           ++K +    Y +     +D  KLKPG  V ++  +  I+  LP E D  V  M  ++   
Sbjct: 84  IVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGN 143

Query: 183 EQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAA 242
             YS+IGGL +QI+EL E I LP+ + E F+ +GI PPKG L+YGPPGTGKTLLARA A+
Sbjct: 144 VSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVAS 203

Query: 243 QTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAG 302
           Q    FLK+    +V  +IG+ A+L+R+ F  A++  P IIF+DE+DAIG +RF    + 
Sbjct: 204 QLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSA 263

Query: 303 DREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEAR 362
           DRE+QRT++ELLNQ+DGF    +VK+I ATNR D LDPALLR GRLDRKI   +PNE+AR
Sbjct: 264 DREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQAR 323

Query: 363 ARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYME 422
             I++IH+  +    +++YE + + +D FNGA  + VC EAGM A+R     +  ED+M+
Sbjct: 324 LDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMK 383

Query: 423 GILEVQAKKK 432
            + +V   KK
Sbjct: 384 AVRKVADSKK 393


>gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  280 bits (717), Expect = 1e-75
 Identities = 163/433 (37%), Positives = 249/433 (57%), Gaps = 43/433 (9%)

Query: 8   ESPVTRQEKMATVWDEAEQDGIGEEV---LKMSTEEIIQRTRLLDSE-IK---IMKSEVL 60
           E P    +   T   E E+   G++V   L + T     R +LL  E IK   +M  E +
Sbjct: 7   ELPAVAAQVAKTRVAEKEEKTKGQDVASKLPLVTLHTQCRLKLLKLERIKDYLLMVEEFI 66

Query: 61  RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK 120
           R   +++ +++K +E   K+   +  P  V N+ E++D +                    
Sbjct: 67  RNQEQIKLLEEKQEEGRSKVDDLRGTPMSVGNLEEIIDDNH------------------- 107

Query: 121 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER 180
            A++ TS    ++  +I  V+ + L+PG  + +    + ++  L  +    V  M+V++ 
Sbjct: 108 -AIVSTSVGSEHYDSIISFVEKDLLEPGCSILLRHKVHAVIGVLMDDTGPLVTMMKVEKA 166

Query: 181 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 240
           P E Y + GGLD QIQE+ E++ LP+ H E +E +G +PPKGV++ GPPGT         
Sbjct: 167 PQETYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGT--------- 217

Query: 241 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 300
                ATFL++ G +L+Q ++GDG KLVR  F +A+E APSI+F DE++AIGTKR+DS  
Sbjct: 218 -----ATFLRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNS 272

Query: 301 AGDREVQRTMLEL--LNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPN 358
            G+RE+Q+TMLEL  LNQL GF     VKVI AT +V+ LDP L+R GR+D+KIEF +P+
Sbjct: 273 GGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPD 332

Query: 359 EEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHE 418
           E+ +  I QIH+ +M ++ DV  ++L    DDF+GA  KA+C EAG++ALR    + T+E
Sbjct: 333 EKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTEAGLMALREHRMKATNE 392

Query: 419 DYMEGILEVQAKK 431
           D+ + I  V  KK
Sbjct: 393 DFKKSIESVLYKK 405


>gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]
          Length = 415

 Score =  280 bits (717), Expect = 1e-75
 Identities = 163/433 (37%), Positives = 249/433 (57%), Gaps = 43/433 (9%)

Query: 8   ESPVTRQEKMATVWDEAEQDGIGEEV---LKMSTEEIIQRTRLLDSE-IK---IMKSEVL 60
           E P    +   T   E E+   G++V   L + T     R +LL  E IK   +M  E +
Sbjct: 7   ELPAVAAQVAKTRVAEKEEKTKGQDVASKLPLVTLHTQCRLKLLKLERIKDYLLMVEEFI 66

Query: 61  RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK 120
           R   +++ +++K +E   K+   +  P  V N+ E++D +                    
Sbjct: 67  RNQEQIKLLEEKQEEGRSKVDDLRGTPMSVGNLEEIIDDNH------------------- 107

Query: 121 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER 180
            A++ TS    ++  +I  V+ + L+PG  + +    + ++  L  +    V  M+V++ 
Sbjct: 108 -AIVSTSVGSEHYDSIISFVEKDLLEPGCSILLRHKVHAVIGVLMDDTGPLVTMMKVEKA 166

Query: 181 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 240
           P E Y + GGLD QIQE+ E++ LP+ H E +E +G +PPKGV++ GPPGT         
Sbjct: 167 PQETYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGT--------- 217

Query: 241 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 300
                ATFL++ G +L+Q ++GDG KLVR  F +A+E APSI+F DE++AIGTKR+DS  
Sbjct: 218 -----ATFLRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNS 272

Query: 301 AGDREVQRTMLEL--LNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPN 358
            G+RE+Q+TMLEL  LNQL GF     VKVI AT +V+ LDP L+R GR+D+KIEF +P+
Sbjct: 273 GGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPD 332

Query: 359 EEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHE 418
           E+ +  I QIH+ +M ++ DV  ++L    DDF+GA  KA+C EAG++ALR    + T+E
Sbjct: 333 EKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTEAGLMALREHRMKATNE 392

Query: 419 DYMEGILEVQAKK 431
           D+ + I  V  KK
Sbjct: 393 DFKKSIESVLYKK 405


>gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo
           sapiens]
          Length = 415

 Score =  280 bits (717), Expect = 1e-75
 Identities = 163/433 (37%), Positives = 249/433 (57%), Gaps = 43/433 (9%)

Query: 8   ESPVTRQEKMATVWDEAEQDGIGEEV---LKMSTEEIIQRTRLLDSE-IK---IMKSEVL 60
           E P    +   T   E E+   G++V   L + T     R +LL  E IK   +M  E +
Sbjct: 7   ELPAVAAQVAKTRVAEKEEKTKGQDVASKLPLVTLHTQCRLKLLKLERIKDYLLMVEEFI 66

Query: 61  RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK 120
           R   +++ +++K +E   K+   +  P  V N+ E++D +                    
Sbjct: 67  RNQEQIKLLEEKQEEGRSKVDDLRGTPMSVGNLEEIIDDNH------------------- 107

Query: 121 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER 180
            A++ TS    ++  +I  V+ + L+PG  + +    + ++  L  +    V  M+V++ 
Sbjct: 108 -AIVSTSVGSEHYDSIISFVEKDLLEPGCSILLRHKVHAVIGVLMDDTGPLVTMMKVEKA 166

Query: 181 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 240
           P E Y + GGLD QIQE+ E++ LP+ H E +E +G +PPKGV++ GPPGT         
Sbjct: 167 PQETYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGT--------- 217

Query: 241 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 300
                ATFL++ G +L+Q ++GDG KLVR  F +A+E APSI+F DE++AIGTKR+DS  
Sbjct: 218 -----ATFLRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNS 272

Query: 301 AGDREVQRTMLEL--LNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPN 358
            G+RE+Q+TMLEL  LNQL GF     VKVI AT +V+ LDP L+R GR+D+KIEF +P+
Sbjct: 273 GGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPD 332

Query: 359 EEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHE 418
           E+ +  I QIH+ +M ++ DV  ++L    DDF+GA  KA+C EAG++ALR    + T+E
Sbjct: 333 EKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTEAGLMALREHRMKATNE 392

Query: 419 DYMEGILEVQAKK 431
           D+ + I  V  KK
Sbjct: 393 DFKKSIESVLYKK 405


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  200 bits (508), Expect = 2e-51
 Identities = 134/409 (32%), Positives = 215/409 (52%), Gaps = 21/409 (5%)

Query: 3   LLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEI--IQRTRLLDSEIKIMKSEVL 60
           L P  E      EK          DGIG EV +     +    R   LD+ ++       
Sbjct: 458 LCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALR----RPG 513

Query: 61  RVTHELQAMKDKIKENSEKI-KVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKG 119
           R   E++      ++  + + K+ + +P+L++   ELL +  +     GA++ +     G
Sbjct: 514 RFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEA-ELLQLANSAHGYVGADLKVLCNEAG 572

Query: 120 KCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDE 179
            CA+ +   +Q   LP + +    K+   D           L+ +     S ++ + +D 
Sbjct: 573 LCALRRILKKQPN-LPDVKVAGLVKITLKDF----------LQAMNDIRPSAMREIAIDV 621

Query: 180 RPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARA 239
            P   +SDIGGL+    +L +A+  P+ H E F  +GIQPPKGVL+YGPPG  KT++A+A
Sbjct: 622 -PNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKA 680

Query: 240 CAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSE 299
            A ++   FL + GP+L+  ++G+  + VR+ F  A+  APSIIF DELDA+  +R  S 
Sbjct: 681 LANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSL 740

Query: 300 KAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNE 359
            AG+    R + +LL ++DG +    V ++AATNR D +D AL+R GR+DR I  P+P+ 
Sbjct: 741 GAGN-VADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDA 799

Query: 360 EARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIAL 408
             R  I ++    M VS +V+ +EL   TD ++GA+  AVC EA ++AL
Sbjct: 800 ATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLAL 848



 Score =  169 bits (427), Expect = 6e-42
 Identities = 101/281 (35%), Positives = 157/281 (55%), Gaps = 22/281 (7%)

Query: 170 SRVKAMEVDERPTEQ-------YSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKG 222
           +RV   E+D+   EQ       Y  IGGL  Q++ + E I LP+   E F++ GI  P+G
Sbjct: 330 TRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRG 389

Query: 223 VLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSI 282
           VL+YGPPGTGKT++ARA A +  A    + GP+++  F G+    +R  FA A  + PSI
Sbjct: 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSI 449

Query: 283 IFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPAL 342
           IFIDELDA+  KR  ++   ++ V  ++L L++ +       QV V+ ATNR   LD AL
Sbjct: 450 IFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAAL 509

Query: 343 LRSGRLDRKIEFPMPNEEARARIMQIHSRKM-NVSPDVNYEELARCTDDFNGAQCKAVCV 401
            R GR D++IE  +PN + R  I+Q   R++ ++  +    +LA     + GA  K +C 
Sbjct: 510 RRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCN 569

Query: 402 EAGMIALRR--------------GATELTHEDYMEGILEVQ 428
           EAG+ ALRR              G  ++T +D+++ + +++
Sbjct: 570 EAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIR 610


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  196 bits (498), Expect = 4e-50
 Identities = 123/365 (33%), Positives = 198/365 (54%), Gaps = 29/365 (7%)

Query: 76  NSEKIKVNKTLPY-LVSNVIELLDVDPNDQEEDGANID---LDSQRKGKCAVIKTSTRQT 131
           + EKI++N+ +   L   + +++ + P    + G  I    +D   +G    +     + 
Sbjct: 78  SDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKP 137

Query: 132 YFLPVIGLVDAEKLKPGDLV----GVNKDSYLILETLPTEY------------DSRVKAM 175
           YFL          ++ GD+     G+    + ++ET P+ Y               +K  
Sbjct: 138 YFLEAY-----RPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKRE 192

Query: 176 EVDERPTEQ-YSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKT 234
           + +E   E  Y DIGG  KQ+ ++ E + LP+ H   F+ +G++PP+G+L+YGPPGTGKT
Sbjct: 193 DEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKT 252

Query: 235 LLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTK 294
           L+ARA A +T A F  + GP+++    G+    +R AF  A++ AP+IIFIDELDAI  K
Sbjct: 253 LIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPK 312

Query: 295 RFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEF 354
           R   EK      +R + +LL  +DG +    V V+AATNR + +DPAL R GR DR+++ 
Sbjct: 313 R---EKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDI 369

Query: 355 PMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATE 414
            +P+   R  I+QIH++ M ++ DV+ E++A  T    GA   A+C EA + A+R+    
Sbjct: 370 GIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDL 429

Query: 415 LTHED 419
           +  ED
Sbjct: 430 IDLED 434



 Score =  192 bits (488), Expect = 5e-49
 Identities = 98/233 (42%), Positives = 145/233 (62%)

Query: 177 VDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLL 236
           V E P   + DIGGL+   +EL E +  P+ H +KF   G+ P KGVL YGPPG GKTLL
Sbjct: 468 VVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLL 527

Query: 237 ARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRF 296
           A+A A + +A F+ + GP+L+ M+ G+    VR+ F  A++ AP ++F DELD+I   R 
Sbjct: 528 AKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARG 587

Query: 297 DSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPM 356
            +   G     R + ++L ++DG      V +I ATNR DI+DPA+LR GRLD+ I  P+
Sbjct: 588 GNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPL 647

Query: 357 PNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALR 409
           P+E++R  I++ + RK  V+ DV+ E LA+ T+ F+GA    +C  A  +A+R
Sbjct: 648 PDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIR 700


>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
          Length = 797

 Score =  188 bits (478), Expect = 7e-48
 Identities = 103/265 (38%), Positives = 159/265 (60%), Gaps = 9/265 (3%)

Query: 167 EYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMY 226
           E  ++V   E+D +    + D+ G ++   E++E +    N K+ +++LG + PKG ++ 
Sbjct: 293 ETTAKVLKDEIDVK----FKDVAGCEEAKLEIMEFVNFLKNPKQ-YQDLGAKIPKGAILT 347

Query: 227 GPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFID 286
           GPPGTGKTLLA+A A +    F+ ++G + ++MF+G G   VRD FALA++ AP I+FID
Sbjct: 348 GPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFID 407

Query: 287 ELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSG 346
           E+DA+G KR      G  E + T+ +LL ++DGF   T V ++A TNR DILDPALLR G
Sbjct: 408 EIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPG 467

Query: 347 RLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELAR----CTDDFNGAQCKAVCVE 402
           R DR+I    P+ + RA I ++H R + +   +  ++LAR     T  F+GA    VC E
Sbjct: 468 RFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNE 527

Query: 403 AGMIALRRGATELTHEDYMEGILEV 427
           A +IA R  +  +  + + + I  V
Sbjct: 528 AALIAARHLSDSINQKHFEQAIERV 552


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  172 bits (436), Expect = 5e-43
 Identities = 94/235 (40%), Positives = 140/235 (59%), Gaps = 1/235 (0%)

Query: 184 QYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQ 243
           ++ D+GG D  ++E+ + ++  M H E + +LG+ PP+GVL++GPPG GKTLLA A A +
Sbjct: 157 KFEDVGGNDMTLKEVCKMLI-HMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGE 215

Query: 244 TKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGD 303
                LK+A P++V    G+  + +R+ F  A   AP IIFIDE+DAI  KR  + K  +
Sbjct: 216 LDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDME 275

Query: 304 REVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARA 363
           R +   +L  ++ L+      +V VI ATNR D LDPAL R+GR DR+I   +P+E +R 
Sbjct: 276 RRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRE 335

Query: 364 RIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHE 418
           RI+Q   RK+ +    ++  LA  T  F GA   A+C EA M A+ R   +L  +
Sbjct: 336 RILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQ 390



 Score =  170 bits (431), Expect = 2e-42
 Identities = 101/276 (36%), Positives = 158/276 (57%), Gaps = 23/276 (8%)

Query: 181 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 240
           P   ++DIG L+   +EL  AI+ P+ + ++F+ LG+  P GVL+ GPPG GKTLLA+A 
Sbjct: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAV 529

Query: 241 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 300
           A ++   F+ + GP+L+ M++G+  + VR  F  AK  AP +IF DE+DA+  +R D E 
Sbjct: 530 ANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 589

Query: 301 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE 360
                  R + +LL ++DG +   QV ++AATNR DI+DPA+LR GRLD+ +   +P   
Sbjct: 590 GAS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPA 646

Query: 361 ARARIMQI---HSRKMNVSPDVNYEELA---RCTDDFNGAQCKAVCVEAGMIALR----- 409
            R  I++    +  K  +  DVN E +A   RC D + GA   A+  EA + ALR     
Sbjct: 647 DRLAILKTITKNGTKPPLDADVNLEAIAGDLRC-DCYTGADLSALVREASICALRQEMAR 705

Query: 410 ------RGATELTHEDYMEGILEVQA--KKKANLQY 437
                 +G  +++H+ + E   +V++   KK  + Y
Sbjct: 706 QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMY 741


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  172 bits (436), Expect = 5e-43
 Identities = 94/235 (40%), Positives = 140/235 (59%), Gaps = 1/235 (0%)

Query: 184 QYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQ 243
           ++ D+GG D  ++E+ + ++  M H E + +LG+ PP+GVL++GPPG GKTLLA A A +
Sbjct: 263 KFEDVGGNDMTLKEVCKMLI-HMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGE 321

Query: 244 TKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGD 303
                LK+A P++V    G+  + +R+ F  A   AP IIFIDE+DAI  KR  + K  +
Sbjct: 322 LDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDME 381

Query: 304 REVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARA 363
           R +   +L  ++ L+      +V VI ATNR D LDPAL R+GR DR+I   +P+E +R 
Sbjct: 382 RRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRE 441

Query: 364 RIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHE 418
           RI+Q   RK+ +    ++  LA  T  F GA   A+C EA M A+ R   +L  +
Sbjct: 442 RILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQ 496



 Score =  170 bits (431), Expect = 2e-42
 Identities = 101/276 (36%), Positives = 158/276 (57%), Gaps = 23/276 (8%)

Query: 181 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 240
           P   ++DIG L+   +EL  AI+ P+ + ++F+ LG+  P GVL+ GPPG GKTLLA+A 
Sbjct: 576 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAV 635

Query: 241 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 300
           A ++   F+ + GP+L+ M++G+  + VR  F  AK  AP +IF DE+DA+  +R D E 
Sbjct: 636 ANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRET 695

Query: 301 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE 360
                  R + +LL ++DG +   QV ++AATNR DI+DPA+LR GRLD+ +   +P   
Sbjct: 696 GAS---VRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPA 752

Query: 361 ARARIMQI---HSRKMNVSPDVNYEELA---RCTDDFNGAQCKAVCVEAGMIALR----- 409
            R  I++    +  K  +  DVN E +A   RC D + GA   A+  EA + ALR     
Sbjct: 753 DRLAILKTITKNGTKPPLDADVNLEAIAGDLRC-DCYTGADLSALVREASICALRQEMAR 811

Query: 410 ------RGATELTHEDYMEGILEVQA--KKKANLQY 437
                 +G  +++H+ + E   +V++   KK  + Y
Sbjct: 812 QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMY 847


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  169 bits (429), Expect = 4e-42
 Identities = 102/268 (38%), Positives = 146/268 (54%), Gaps = 16/268 (5%)

Query: 149 DLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNH 208
           +L G+ KD   I  +L     + V  M++D   + ++  +GGL   I  L E +V P+ +
Sbjct: 396 ELKGIYKDRMKIGASL-----ADVDPMQLDS--SVRFDSVGGLSNHIAALKEMVVFPLLY 448

Query: 209 KEKFENLGIQPPKGVLMYGPPGTGKTLLARACA-----AQTKATFLKLAGPQLVQMFIGD 263
            E FE   IQPP+G L YGPPGTGKTL+ARA A        +  F    G   +  ++G+
Sbjct: 449 PEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGE 508

Query: 264 GAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPN 323
             + +R  F  A +  PSIIF DE+D +   R   +      +  T+L L   +DG    
Sbjct: 509 SERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDSR 565

Query: 324 TQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSP-DVNYE 382
            ++ VI ATNR+D +DPAL R GR DR+  F +P++EAR  I++IH+R  N  P D   E
Sbjct: 566 GEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLE 625

Query: 383 ELARCTDDFNGAQCKAVCVEAGMIALRR 410
           ELA     + GA  K++C EA + ALRR
Sbjct: 626 ELAENCVGYCGADIKSICAEAALCALRR 653


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  168 bits (425), Expect = 1e-41
 Identities = 101/286 (35%), Positives = 160/286 (55%), Gaps = 26/286 (9%)

Query: 165 PTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVL 224
           P+ + S +  M++  +P + + +IGGL+    +L ++I  P+    +F  +G+  PKGVL
Sbjct: 446 PSSFRSVIGLMDI--KPVD-WEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVL 502

Query: 225 MYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIF 284
           +YGPPG  KT L RA A     +F+ ++G  L   F+GD  K++   F  A+   P+I+F
Sbjct: 503 LYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILF 562

Query: 285 IDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDG-----------------FQP--NTQ 325
           +DE+D+I   R  + K G    +R +  LLN+LDG                 FQ   N  
Sbjct: 563 LDEIDSILGAR-SASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRS 621

Query: 326 VKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELA 385
           V +IAATNR D+LD ALLR GRLD+ I  P P+ + R  I+++ ++ M + PDV+ E LA
Sbjct: 622 VMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLA 681

Query: 386 RCTDDFNGAQCKAVCVEAGMIALRRG---ATELTHEDYMEGILEVQ 428
             T  F+GA  + +C EA ++AL+     AT +  E +++ +  V+
Sbjct: 682 AETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTVK 727



 Score =  139 bits (349), Expect = 7e-33
 Identities = 87/225 (38%), Positives = 124/225 (55%), Gaps = 10/225 (4%)

Query: 188 IGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKAT 247
           +GGL +    L E + LP+ +      LG+  P+GVL+ GPPG GKT L RA A +  A 
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261

Query: 248 FLKLAGPQLVQMFIGDGAKLVRDAFALAKEKA---PSIIFIDELDAIGTKRFDSEKAGDR 304
            L ++ P L     G+  + VR  F  A+E A   PS++F+DE+DA+  +R      G R
Sbjct: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR------GSR 315

Query: 305 EVQ-RTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARA 363
             + R + ++L  LDG   + +V V+ ATNR D LDPAL R GR DR++    P  + R 
Sbjct: 316 APESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRK 375

Query: 364 RIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIAL 408
            I+Q+ + KM +S  V+   LA  T  + GA   A+C EA M AL
Sbjct: 376 EILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  168 bits (425), Expect = 1e-41
 Identities = 103/258 (39%), Positives = 152/258 (58%), Gaps = 10/258 (3%)

Query: 161 LETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPP 220
           LE L T +   V A ++   P+  + D+GGL +  +E++E I LP+ H E   +LG++  
Sbjct: 683 LEQLQTAHSQAVGAPKI---PSVSWHDVGGLQEVKKEILETIQLPLEHPELL-SLGLRR- 737

Query: 221 KGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAP 280
            G+L++GPPGTGKTLLA+A A +   TFL + GP+L+ M++G   + VR+ FA A+  AP
Sbjct: 738 SGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAP 797

Query: 281 SIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDP 340
            IIF DELD++   R  S  +G   + R + +LL +LDG      V VI ATNR D+LDP
Sbjct: 798 CIIFFDELDSLAPSRGRSGDSGG-VMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDP 856

Query: 341 ALLRSGRLDRKIEFPMPNEE--ARARIMQIHSRKMNVSPDVN-YEELARCTDDFNGAQCK 397
           ALLR GR D K+ F   NE+  ++ R++   +RK  + P V+    L  C     GA   
Sbjct: 857 ALLRPGRFD-KLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLY 915

Query: 398 AVCVEAGMIALRRGATEL 415
           ++C +A   AL+R   +L
Sbjct: 916 SLCSDAMTAALKRRVHDL 933



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 42/164 (25%), Positives = 73/164 (44%), Gaps = 4/164 (2%)

Query: 223 VLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSI 282
           VL+ GPPG GKT +  A  +      LK+    L     G     ++  F+ A+   P++
Sbjct: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525

Query: 283 IFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPAL 342
           + +  +D +G  R       D  V   +  LL   D       + V+A T+R   L PA 
Sbjct: 526 LLLTAVDLLGRDR--DGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PAD 582

Query: 343 LRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELAR 386
           +++     ++E P  +E  R  I++  +  + +  +VN  +LAR
Sbjct: 583 VQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLAR 625


>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
          Length = 795

 Score =  165 bits (418), Expect = 7e-41
 Identities = 100/256 (39%), Positives = 147/256 (57%), Gaps = 13/256 (5%)

Query: 185 YSDIGGLDK---QIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACA 241
           + D+ G+ +   +++E V+ +  P    E+F  LG + PKG L+ GPPG GKTLLA+A A
Sbjct: 308 FKDVAGMHEAKLEVREFVDYLKSP----ERFLQLGAKVPKGALLLGPPGCGKTLLAKAVA 363

Query: 242 AQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKA 301
            + +  FL +AGP+ V++  G GA  VR  F  A+ +AP I++IDE+DA+G KR  +   
Sbjct: 364 TEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSG 423

Query: 302 -GDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE 360
             + E ++T+ +LL ++DG      V V+A+TNR DILD AL+R GRLDR +   +P  +
Sbjct: 424 FSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQ 483

Query: 361 ARARIMQIH--SRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATE---L 415
            R  I + H  S K+  S     + LA  T  F+GA    +C EA + A R G T    L
Sbjct: 484 ERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTL 543

Query: 416 THEDYMEGILEVQAKK 431
             E  +E +L   AKK
Sbjct: 544 NFEYAVERVLAGTAKK 559


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  165 bits (417), Expect = 9e-41
 Identities = 92/225 (40%), Positives = 136/225 (60%), Gaps = 5/225 (2%)

Query: 185  YSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQT 244
            +  IGGL +  Q L++ I LP  + E F NL I+   G+L+YGPPGTGKTLLA   A ++
Sbjct: 839  WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898

Query: 245  KATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKR-FDSEKAGD 303
            +  F+ + GP+L+  +IG   + VRD F  A+   P I+F DE ++I  +R  D+    D
Sbjct: 899  RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTD 958

Query: 304  REVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARA 363
            R V     +LL QLDG +    V V+AAT+R D++DPALLR GRLD+ +  P P++ +R 
Sbjct: 959  RVVN----QLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRL 1014

Query: 364  RIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIAL 408
             I+ + S  + ++ DV+ + +A  TD F GA  KA+   A + AL
Sbjct: 1015 EILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059



 Score = 28.9 bits (63), Expect = 9.7
 Identities = 42/190 (22%), Positives = 78/190 (41%), Gaps = 26/190 (13%)

Query: 223 VLMYGPPGTGKTLLARACAAQT---------KATFLKLAGPQLVQMFIGDGAKLVRDAFA 273
           +L+ G  G+GK+ LA+A   +          +     L G +L  +      K +  AF+
Sbjct: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENI-----QKTLEVAFS 649

Query: 274 LAKEKAPSIIFIDELDAIGTKRF--DSEKAGDREVQRTMLELLNQL--DGFQPNTQVKVI 329
            A    PS++ +D+LD I       + E + D    + +   LN +  +     + V +I
Sbjct: 650 EAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALI 709

Query: 330 AATNRVDILDPALLRSGRL---DRKIEFPMPNEEARARIM-QIHSRKM----NVSPDVNY 381
           A +     L P L+ +  +           PN+E R  I+  +   K+    N   D++ 
Sbjct: 710 ATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDL 769

Query: 382 EELARCTDDF 391
           + +A+ T  F
Sbjct: 770 QHVAKETGGF 779


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  163 bits (413), Expect = 3e-40
 Identities = 98/245 (40%), Positives = 134/245 (54%), Gaps = 11/245 (4%)

Query: 172 VKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGT 231
           V  M +D+  + ++  IGGL   I  L E +V P+ + E FE   IQPP+G L YGPPGT
Sbjct: 388 VDPMNIDK--SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGT 445

Query: 232 GKTLLARACA-----AQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFID 286
           GKTL+ARA A        K  F    G   +  ++G+  + +R  F  A    PSIIF D
Sbjct: 446 GKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFD 505

Query: 287 ELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSG 346
           E+D +   R   +      +  T+L L   +DG     ++ VI ATNR+D +DPAL R G
Sbjct: 506 EIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDNRGEIVVIGATNRLDSIDPALRRPG 562

Query: 347 RLDRKIEFPMPNEEARARIMQIHSRKMNVS-PDVNYEELARCTDDFNGAQCKAVCVEAGM 405
           R DR+  F +P+++AR  I+QIH+R  N    D    ELA     + GA  KA+C EA +
Sbjct: 563 RFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAAL 622

Query: 406 IALRR 410
           IALRR
Sbjct: 623 IALRR 627


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score =  160 bits (405), Expect = 2e-39
 Identities = 97/271 (35%), Positives = 155/271 (57%), Gaps = 7/271 (2%)

Query: 150 LVGVNKDSYLILE-TLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNH 208
           + G+ K+ +L +     T  DS V  +++     E    +    +++QE+VE +  P   
Sbjct: 305 IYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNP--- 361

Query: 209 KEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLV 268
            +KF  LG + PKG+L+ GPPGTGKTLLARA A +    F   +G +  +MF+G GA  +
Sbjct: 362 -QKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRI 420

Query: 269 RDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKV 328
           R+ F  AK  AP +IFIDELD++G KR +S        ++T+ +LL ++DGF+PN  V +
Sbjct: 421 RNLFREAKANAPCVIFIDELDSVGGKRIESPM--HPYSRQTINQLLAEMDGFKPNEGVII 478

Query: 329 IAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCT 388
           I ATN  + LD AL+R GR D ++  P P+ + R  I++ +  K+     V+ E +AR T
Sbjct: 479 IGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGT 538

Query: 389 DDFNGAQCKAVCVEAGMIALRRGATELTHED 419
             F+GA+ + +  +A + A   G   +T ++
Sbjct: 539 VGFSGAELENLVNQAALKAAVDGKEMVTMKE 569


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score =  160 bits (405), Expect = 2e-39
 Identities = 97/271 (35%), Positives = 155/271 (57%), Gaps = 7/271 (2%)

Query: 150 LVGVNKDSYLILE-TLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNH 208
           + G+ K+ +L +     T  DS V  +++     E    +    +++QE+VE +  P   
Sbjct: 248 IYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNP--- 304

Query: 209 KEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLV 268
            +KF  LG + PKG+L+ GPPGTGKTLLARA A +    F   +G +  +MF+G GA  +
Sbjct: 305 -QKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRI 363

Query: 269 RDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKV 328
           R+ F  AK  AP +IFIDELD++G KR +S        ++T+ +LL ++DGF+PN  V +
Sbjct: 364 RNLFREAKANAPCVIFIDELDSVGGKRIESPM--HPYSRQTINQLLAEMDGFKPNEGVII 421

Query: 329 IAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCT 388
           I ATN  + LD AL+R GR D ++  P P+ + R  I++ +  K+     V+ E +AR T
Sbjct: 422 IGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGT 481

Query: 389 DDFNGAQCKAVCVEAGMIALRRGATELTHED 419
             F+GA+ + +  +A + A   G   +T ++
Sbjct: 482 VGFSGAELENLVNQAALKAAVDGKEMVTMKE 512


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  156 bits (395), Expect = 3e-38
 Identities = 101/275 (36%), Positives = 159/275 (57%), Gaps = 22/275 (8%)

Query: 172 VKAME---VDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGP 228
           V+A+E   V   P+  + DI  L++  + L EA+VLPM   + F+ +  +P KGVLM GP
Sbjct: 191 VEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGP 249

Query: 229 PGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDEL 288
           PGTGKT+LA+A A +   TF  ++   L   + G+  KLVR  F +A+  AP+ IFIDE+
Sbjct: 250 PGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEI 309

Query: 289 DAIGTKRFDSEKAGDREVQRTMLELLNQLDGF-------QPNTQVKVIAATNRVDILDPA 341
           D+I ++R  S++      +R   ELL Q+DG         P+  V V+AATN    +D A
Sbjct: 310 DSICSRRGTSDE--HEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEA 367

Query: 342 LLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCV 401
           L R  RL+++I  P+P  + RA +++I+ R++ + PD+  E++A   + ++GA    VC 
Sbjct: 368 LRR--RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCR 425

Query: 402 EAGMIALRRGATELTHEDYMEGILEVQAKKKANLQ 436
           +A ++A+RR    L+ E       E++A  K  LQ
Sbjct: 426 DASLMAMRRRINGLSPE-------EIRALSKEELQ 453


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  156 bits (395), Expect = 3e-38
 Identities = 101/275 (36%), Positives = 159/275 (57%), Gaps = 22/275 (8%)

Query: 172 VKAME---VDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGP 228
           V+A+E   V   P+  + DI  L++  + L EA+VLPM   + F+ +  +P KGVLM GP
Sbjct: 191 VEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGP 249

Query: 229 PGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDEL 288
           PGTGKT+LA+A A +   TF  ++   L   + G+  KLVR  F +A+  AP+ IFIDE+
Sbjct: 250 PGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEI 309

Query: 289 DAIGTKRFDSEKAGDREVQRTMLELLNQLDGF-------QPNTQVKVIAATNRVDILDPA 341
           D+I ++R  S++      +R   ELL Q+DG         P+  V V+AATN    +D A
Sbjct: 310 DSICSRRGTSDE--HEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEA 367

Query: 342 LLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCV 401
           L R  RL+++I  P+P  + RA +++I+ R++ + PD+  E++A   + ++GA    VC 
Sbjct: 368 LRR--RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCR 425

Query: 402 EAGMIALRRGATELTHEDYMEGILEVQAKKKANLQ 436
           +A ++A+RR    L+ E       E++A  K  LQ
Sbjct: 426 DASLMAMRRRINGLSPE-------EIRALSKEELQ 453


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  155 bits (392), Expect = 7e-38
 Identities = 103/282 (36%), Positives = 160/282 (56%), Gaps = 21/282 (7%)

Query: 154 NKDSYLILETLPTEYDSR------VKAMEVD---ERPTEQYSDIGGLDKQIQELVEAIVL 204
           NK    + E    ++DS       V+A+E D   + P  ++ DI  L +  + L EA+VL
Sbjct: 168 NKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVL 227

Query: 205 PMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDG 264
           PM   E F+ +  +P KGVLM GPPGTGKTLLA+A A + K TF  ++   L   + G+ 
Sbjct: 228 PMWMPEFFKGIR-RPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGES 286

Query: 265 AKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGF---- 320
            KLVR  F +A+  +P+ IFIDE+D+I ++R  SE+      +R   ELL Q+DG     
Sbjct: 287 EKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEE--HEASRRVKAELLVQMDGVGGTS 344

Query: 321 ---QPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSP 377
               P+  V V+AATN    +D AL R  RL+++I  P+P+ + R  +++I  R++ ++ 
Sbjct: 345 ENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPSAKGREELLRISLRELELAD 402

Query: 378 DVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHED 419
           DV+   +A   + ++GA    VC +A ++A+RR    LT E+
Sbjct: 403 DVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEE 444


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  146 bits (368), Expect = 4e-35
 Identities = 91/259 (35%), Positives = 140/259 (54%), Gaps = 5/259 (1%)

Query: 166 TEYDSRVKAMEVDERPTE-QYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGI-QPPKGV 223
           +EY+  + A  VD       +SDI GLD  I +L + ++LP+  K  FEN  + QPPKGV
Sbjct: 70  SEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGV 129

Query: 224 LMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSII 283
           L+YGPPG GKTL+A+A A +    F+ L    L   + G+  KL    F+LA +  PSII
Sbjct: 130 LLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSII 189

Query: 284 FIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALL 343
           FIDE+D+    R  S+      ++   + L + LD    + QV V+ ATNR   LD A++
Sbjct: 190 FIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLD-TDHSCQVIVMGATNRPQDLDSAIM 248

Query: 344 RSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEA 403
           R  R+  +     P  + R  I+++  +  NV   V+  E+A+ TD F+G+  K +C +A
Sbjct: 249 R--RMPTRFHINQPALKQREAILKLILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDA 306

Query: 404 GMIALRRGATELTHEDYME 422
            ++ +R      + E + E
Sbjct: 307 ALLCVREYVNSTSEESHDE 325


>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score =  142 bits (358), Expect = 6e-34
 Identities = 89/237 (37%), Positives = 139/237 (58%), Gaps = 10/237 (4%)

Query: 181 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 240
           P  +++DI GLD   Q + EA+V P+ + + F  + + P KG+L+YGPPGTGKTLLA+A 
Sbjct: 177 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAV 235

Query: 241 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 300
           A + K TF  ++   +V  + GD  KLVR  F LA+  APS IF+DEL+++ ++R  +  
Sbjct: 236 ATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASG 295

Query: 301 AGDREVQRTMLELLNQLDGF-QPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNE 359
                  R   ELL Q+DG  +    V V+AA+N    LD A+LR  RL+++I   +P+ 
Sbjct: 296 GEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPSR 353

Query: 360 EARARIMQ------IHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRR 410
           EAR  ++         SR + +  ++ Y  L++ T+ ++G+  K VC EA M  +R+
Sbjct: 354 EARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 410


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  142 bits (357), Expect = 8e-34
 Identities = 91/237 (38%), Positives = 135/237 (56%), Gaps = 11/237 (4%)

Query: 177 VDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLL 236
           VD     ++ DI G D   Q L E ++LP    E F  L   P +G+L++GPPG GKT+L
Sbjct: 301 VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTML 359

Query: 237 ARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRF 296
           A+A AA++ ATF  ++   L   ++G+G KLVR  FA+A+E  PSIIFIDE+D++  +R 
Sbjct: 360 AKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERR 419

Query: 297 DSEKAGDREVQRTMLELLNQLDGFQP--NTQVKVIAATNRVDILDPALLRSGRLDRKIEF 354
           + E    R   R   E L + DG Q   + +V V+ ATNR   LD A+LR  R  +++  
Sbjct: 420 EGEHDASR---RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYV 474

Query: 355 PMPNEEARARIMQIHSRKMNVSPDVNYE--ELARCTDDFNGAQCKAVCVEAGMIALR 409
            +PNEE R  +++    K   SP    E  +LAR TD ++G+   A+  +A +  +R
Sbjct: 475 SLPNEETRLLLLKNLLCKQG-SPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR 530


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.134    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,546,386
Number of Sequences: 37866
Number of extensions: 672746
Number of successful extensions: 2618
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 2413
Number of HSP's gapped (non-prelim): 188
length of query: 439
length of database: 18,247,518
effective HSP length: 105
effective length of query: 334
effective length of database: 14,271,588
effective search space: 4766710392
effective search space used: 4766710392
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.