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Search of human proteins with 19923181
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens]
(330 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens] 692 0.0
gi|196162711 PDZ and LIM domain 4 isoform 2 [Homo sapiens] 467 e-132
gi|13994151 PDZ and LIM domain 1 [Homo sapiens] 264 7e-71
gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens] 263 2e-70
gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens] 255 4e-68
gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens] 170 2e-42
gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens] 152 5e-37
gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens] 122 6e-28
gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens] 120 2e-27
gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens] 111 8e-25
gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens] 108 9e-24
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens] 108 9e-24
gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens] 103 3e-22
gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens] 100 1e-21
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens] 100 1e-21
gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens] 98 1e-20
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens] 97 2e-20
gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens] 92 8e-19
gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens] 91 1e-18
gi|166706868 synaptopodin 2-like isoform a [Homo sapiens] 65 6e-11
gi|193083191 synaptopodin 2 isoform c [Homo sapiens] 60 2e-09
gi|193083185 synaptopodin 2 isoform b [Homo sapiens] 60 2e-09
gi|193083183 synaptopodin 2 isoform a [Homo sapiens] 60 2e-09
gi|122937269 Wilms tumor 1 interacting protein [Homo sapiens] 56 4e-08
gi|170932518 paxillin isoform 3 [Homo sapiens] 56 5e-08
gi|170932516 paxillin isoform 2 [Homo sapiens] 56 5e-08
gi|91208423 thyroid receptor-interacting protein 6 [Homo sapiens] 55 9e-08
gi|4502175 apical protein of Xenopus-like [Homo sapiens] 54 3e-07
gi|221316659 leupaxin isoform 1 [Homo sapiens] 53 3e-07
gi|4758670 leupaxin isoform 2 [Homo sapiens] 53 3e-07
>gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens]
Length = 330
Score = 692 bits (1785), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM
Sbjct: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
Query: 61 THLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS 120
THLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS
Sbjct: 61 THLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS 120
Query: 121 GTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSR 180
GTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSR
Sbjct: 121 GTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSR 180
Query: 181 DCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTAS 240
DCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTAS
Sbjct: 181 DCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTAS 240
Query: 241 KLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERL 300
KLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERL
Sbjct: 241 KLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERL 300
Query: 301 YCESHAKARVKPPEGYDVVAVYPNAKVELV 330
YCESHAKARVKPPEGYDVVAVYPNAKVELV
Sbjct: 301 YCESHAKARVKPPEGYDVVAVYPNAKVELV 330
>gi|196162711 PDZ and LIM domain 4 isoform 2 [Homo sapiens]
Length = 246
Score = 467 bits (1201), Expect = e-132
Identities = 228/240 (95%), Positives = 230/240 (95%)
Query: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM
Sbjct: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
Query: 61 THLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS 120
THLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS
Sbjct: 61 THLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS 120
Query: 121 GTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSR 180
GTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSR
Sbjct: 121 GTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSR 180
Query: 181 DCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTAS 240
DCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGG G + P+AS
Sbjct: 181 DCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGAPSSRHGTSSTIPSAS 240
>gi|13994151 PDZ and LIM domain 1 [Homo sapiens]
Length = 329
Score = 264 bits (675), Expect = 7e-71
Identities = 147/330 (44%), Positives = 197/330 (59%), Gaps = 18/330 (5%)
Query: 5 VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64
+ L+GP PWGFRLVGG+DF PL ISRV GSKAALA LC GD+I AI+GE+T MTHLE
Sbjct: 6 IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65
Query: 65 AQNRIKGCHDHLTLSVSRPEGRSW-PSAPDDSKAQAHRIHIDPEIQD-----GSPTTSRR 118
AQNRIKGC D+LTL+V+R E + W P ++ K +++++ E Q+ + S
Sbjct: 66 AQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSAM 125
Query: 119 PSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSS-----EATLPAQMSTLHVSPPPSADPA 173
P + + Y P N S+ E+ A + P A P
Sbjct: 126 PFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQPP 185
Query: 174 RGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPR 233
L +D SEVY+ML+E E + PKQS SF LQ +LE+ E GD P G R
Sbjct: 186 SSLV------IDKESEVYKMLQEKQE-LNEPPKQSTSFLVLQEILESEEKGDPNKPSGFR 238
Query: 234 NLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGY 293
++K +K+ A + Q LP C +CG GIVG VK RD+ HPEC++C+DCG NLKQ+G+
Sbjct: 239 SVKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGH 298
Query: 294 FFLDERLYCESHAKARVKPPEGYDVVAVYP 323
FF+++++YCE HA+ RV PPEGY+VV V+P
Sbjct: 299 FFVEDQIYCEKHARERVTPPEGYEVVTVFP 328
>gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens]
Length = 316
Score = 263 bits (672), Expect = 2e-70
Identities = 146/332 (43%), Positives = 196/332 (59%), Gaps = 23/332 (6%)
Query: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
MP +V L GP+PWGFRL GG DF+ PL I+R+ GSKAA A LCPGD+I AI+G TE M
Sbjct: 1 MPQTVILPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESM 60
Query: 61 THLEAQNRIKGCHDHLTLSVSRPEGRSW-PSAPDDSKAQAHRIHIDPEIQDGSPTTSR-- 117
TH +AQ+RIK L L + R E W P +D KA +I+++ E Q+ P +
Sbjct: 61 THADAQDRIKAAAHQLCLKIDRGETHLWSPQVSEDGKAHPFKINLESEPQEFKPIGTAHN 120
Query: 118 ---RPSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPAR 174
+P +D R + + Y P + + + L Q+ L S P + +P
Sbjct: 121 RRAQPFVAAANIDDKRQVVSASYNSP--IGLYSTSNIQDALHGQLRGLIPSSPQN-EPTA 177
Query: 175 GLPRSRDCRVDLGSEVYRMLREPA-EPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPR 233
+P S+VYRML + EP +P+QSGSFR LQGM++ G P G R
Sbjct: 178 SVPPE--------SDVYRMLHDNRNEPT--QPRQSGSFRVLQGMVDDGSDDR---PAGTR 224
Query: 234 NLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGY 293
+++ +K+ G Q +P C +CG GIVG +VKARDK HPECF+C+DC LNLKQ+GY
Sbjct: 225 SVRAPVTKVHGGSGGAQRMPLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGY 284
Query: 294 FFLDERLYCESHAKARVKPPEGYDVVAVYPNA 325
FF++ LYCE+HA+AR KPPEGYD V +YP A
Sbjct: 285 FFIEGELYCETHARARTKPPEGYDTVTLYPKA 316
>gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens]
Length = 364
Score = 255 bits (651), Expect = 4e-68
Identities = 152/377 (40%), Positives = 198/377 (52%), Gaps = 65/377 (17%)
Query: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
MP +V L GP+PWGFRL GG DF+ PL I+R+ GSKAA A LCPGD+I AI+G TE M
Sbjct: 1 MPQTVILPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESM 60
Query: 61 THLEAQNRIKGCHDHLTLSVSRPEGRSW-PSAPDDSKAQAHRIHIDPEIQDGSPTTSRR- 118
TH +AQ+RIK L L + R E W P +D KA +I+++ E QDG+ +
Sbjct: 61 THADAQDRIKAAAHQLCLKIDRGETHLWSPQVSEDGKAHPFKINLESEPQDGNYFEHKHN 120
Query: 119 -----------------PSGTGTGPEDGRPSLGSPYGQ------------PPRFPVP--- 146
PSG G PS S P P+
Sbjct: 121 IRPKPFVIPGRSSGCSTPSGIDCGSGRSTPSSVSTVSTICPGDLKVAAKLAPNIPLEMEL 180
Query: 147 -----------------HNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSE 189
+ + TL Q+ST P ++P +P S+
Sbjct: 181 PGVKIVHAQFNTPMQLYSDDNIMETLQGQVSTALGETPLMSEPTASVPPE--------SD 232
Query: 190 VYRMLREPA-EPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSG 248
VYRML + EP +P+QSGSFR LQGM++ G P G R+++ +K+ G
Sbjct: 233 VYRMLHDNRNEPT--QPRQSGSFRVLQGMVDDGSDDR---PAGTRSVRAPVTKVHGGSGG 287
Query: 249 LQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHAKA 308
Q +P C +CG GIVG +VKARDK HPECF+C+DC LNLKQ+GYFF++ LYCE+HA+A
Sbjct: 288 AQRMPLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFIEGELYCETHARA 347
Query: 309 RVKPPEGYDVVAVYPNA 325
R KPPEGYD V +YP A
Sbjct: 348 RTKPPEGYDTVTLYPKA 364
>gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens]
Length = 352
Score = 170 bits (430), Expect = 2e-42
Identities = 121/355 (34%), Positives = 165/355 (46%), Gaps = 52/355 (14%)
Query: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
M +V + GP+PWGFR+ GGRDF P+ +++V KA A L PGD+I AINGES E M
Sbjct: 1 MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
Query: 61 THLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS 120
H EAQ++I+ L L + R + S DS + ++ + + S S
Sbjct: 61 LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120
Query: 121 GTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSP-------------- 166
+ P P GSP+ PP + + EA + +L SP
Sbjct: 121 SYSS-PTSLSPRAGSPFSPPPS---SSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRP 176
Query: 167 ------------------PPSADPARGLPRSRDCR-----VDLGSEVYRMLREPAEPVAA 203
PPS P P S D +D SEV++ML+E E AA
Sbjct: 177 GSRQAGLGRAGDSAVLVLPPSPGPRSSRP-SMDSEGGSLLLDEDSEVFKMLQENREGRAA 235
Query: 204 EPKQSGSFRYLQGMLEAGEGGDWPG--PGG--PRNLKPTASKLGAPLSGLQGLPECTRCG 259
P+QS SFR LQ LEA E G P P P++ P + L P L C +C
Sbjct: 236 -PRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPK----LHTCEKCS 290
Query: 260 HGIVGTIVKARDKLY-HPECFMCSDCGLNLKQRGYFFLDERLYCESHAKARVKPP 313
I V+ ++ Y HP C+ C+DCGLNLK RG+F++ + LYCE HA+ R P
Sbjct: 291 TSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAP 345
>gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens]
Length = 366
Score = 152 bits (383), Expect = 5e-37
Identities = 114/339 (33%), Positives = 155/339 (45%), Gaps = 52/339 (15%)
Query: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
M +V + GP+PWGFR+ GGRDF P+ +++V KA A L PGD+I AINGES E M
Sbjct: 1 MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
Query: 61 THLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS 120
H EAQ++I+ L L + R + S DS + ++ + + S S
Sbjct: 61 LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120
Query: 121 GTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSP-------------- 166
+ P P GSP+ PP + + EA + +L SP
Sbjct: 121 SYSS-PTSLSPRAGSPFSPPPS---SSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRP 176
Query: 167 ------------------PPSADPARGLPRSRDCR-----VDLGSEVYRMLREPAEPVAA 203
PPS P P S D +D SEV++ML+E E AA
Sbjct: 177 GSRQAGLGRAGDSAVLVLPPSPGPRSSRP-SMDSEGGSLLLDEDSEVFKMLQENREGRAA 235
Query: 204 EPKQSGSFRYLQGMLEAGEGGDWPG--PGG--PRNLKPTASKLGAPLSGLQGLPECTRCG 259
P+QS SFR LQ LEA E G P P P++ P + L P L C +C
Sbjct: 236 -PRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPK----LHTCEKCS 290
Query: 260 HGIVGTIVKARDKLY-HPECFMCSDCGLNLKQRGYFFLD 297
I V+ ++ Y HP C+ C+DCGLNLK RG+F+ D
Sbjct: 291 TSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWED 329
>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
Length = 423
Score = 122 bits (305), Expect = 6e-28
Identities = 104/333 (31%), Positives = 147/333 (44%), Gaps = 58/333 (17%)
Query: 5 VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64
V L GP+PWGFRL GG+DF+ PL+ISR+ G KAA A + GD + +I+GE+ +TH+E
Sbjct: 6 VVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIE 65
Query: 65 AQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQA-HRIHIDPEIQDGSP------TTSR 117
AQN+I+ C + L+L +SR + P K Q + + P + D S T
Sbjct: 66 AQNKIRACGERLSLGLSRAQ----PVQSKPQKVQTPDKQPLRPLVPDASKQRLMENTEDW 121
Query: 118 RP-SGTG-----------TGPE---DGRPSLGSPYGQPPR--FPVPHNGSSEATLPAQMS 160
RP GTG TG E D Q PR P P + + + P +
Sbjct: 122 RPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTA 181
Query: 161 TLHVSPPP-SADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLE 219
S PP + DPA + D + +L ++P P QS + +++
Sbjct: 182 PSPTSRPPWAVDPAFAERYAPD-------KTSTVLTRHSQPATPTPLQSRT-----SIVQ 229
Query: 220 AGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECF 279
A GG PGG N T P C +C I G + A YHPE F
Sbjct: 230 AAAGG---VPGGGSNNGKT--------------PVCHQCHKVIRGRYLVALGHAYHPEEF 272
Query: 280 MCSDCGLNLKQRGYFFLDERLYCESHAKARVKP 312
+CS CG L++ G+F ++C R P
Sbjct: 273 VCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
Score = 37.0 bits (84), Expect = 0.024
Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 14/75 (18%)
Query: 250 QGLPECTRCGHGIVGTI-------VKARDKL-------YHPECFMCSDCGLNLKQRGYFF 295
+G+P C R + GT + A D+ +H CF+C+ C +NL+ + ++
Sbjct: 349 EGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYS 408
Query: 296 LDERLYCESHAKARV 310
+R C+SHA + V
Sbjct: 409 KKDRPLCKSHAFSHV 423
>gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]
Length = 457
Score = 120 bits (301), Expect = 2e-27
Identities = 109/363 (30%), Positives = 153/363 (42%), Gaps = 84/363 (23%)
Query: 5 VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64
V L GP+PWGFRL GG+DF+ PL+ISR+ G KAA A + GD + +I+GE+ +TH+E
Sbjct: 6 VVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIE 65
Query: 65 AQNRIKGCHDHLTLSVSR-------PEGRSWPSA------------------------PD 93
AQN+I+ C + L+L +SR P+ S P+A P
Sbjct: 66 AQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFGAPPPA 125
Query: 94 DSKAQAHRIHIDPEIQDGSP------TTSRRP-SGTG-----------TGPE---DGRPS 132
DS Q + + P + D S T RP GTG TG E D
Sbjct: 126 DSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEE 185
Query: 133 LGSPYGQPPR--FPVPHNGSSEATLPAQMSTLHVSPPP-SADPARGLPRSRDCRVDLGSE 189
Q PR P P + + + P + S PP + DPA + D +
Sbjct: 186 HLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPD-------K 238
Query: 190 VYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSGL 249
+L ++P P QS + +++A GG PGG N T
Sbjct: 239 TSTVLTRHSQPATPTPLQSRT-----SIVQAAAGG---VPGGGSNNGKT----------- 279
Query: 250 QGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHAKAR 309
P C +C I G + A YHPE F+CS CG L++ G+F ++C R
Sbjct: 280 ---PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVR 336
Query: 310 VKP 312
P
Sbjct: 337 YAP 339
Score = 37.0 bits (84), Expect = 0.024
Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 14/75 (18%)
Query: 250 QGLPECTRCGHGIVGTI-------VKARDKL-------YHPECFMCSDCGLNLKQRGYFF 295
+G+P C R + GT + A D+ +H CF+C+ C +NL+ + ++
Sbjct: 383 EGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYS 442
Query: 296 LDERLYCESHAKARV 310
+R C+SHA + V
Sbjct: 443 KKDRPLCKSHAFSHV 457
>gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens]
Length = 278
Score = 111 bits (278), Expect = 8e-25
Identities = 87/261 (33%), Positives = 117/261 (44%), Gaps = 43/261 (16%)
Query: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
M +V + GP+PWGFR+ GGRDF P+ +++V KA A L PGD+I AINGES E M
Sbjct: 1 MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGM 60
Query: 61 THLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS 120
H EAQ++I+ L L + R + S DS + ++ + + S S
Sbjct: 61 LHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRS 120
Query: 121 GTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSP-------------- 166
+ P P GSP+ PP + + EA + +L SP
Sbjct: 121 SYSS-PTSLSPRAGSPFSPPPS---SSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRP 176
Query: 167 ------------------PPSADPARGLPRSRDCR-----VDLGSEVYRMLREPAEPVAA 203
PPS P P S D +D SEV++ML+E E AA
Sbjct: 177 GSRQAGLGRAGDSAVLVLPPSPGPRSSRP-SMDSEGGSLLLDEDSEVFKMLQENREGRAA 235
Query: 204 EPKQSGSFRYLQGMLEAGEGG 224
P+QS SFR LQ LEA E G
Sbjct: 236 -PRQSSSFRLLQEALEAEERG 255
>gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens]
Length = 330
Score = 108 bits (269), Expect = 9e-24
Identities = 86/259 (33%), Positives = 124/259 (47%), Gaps = 27/259 (10%)
Query: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
M +SVTL GP PWGFRL GG+DF+ PLTISR+ GSKAA + L GDL+ AI+G +T+ M
Sbjct: 1 MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60
Query: 61 THLEAQNRIKGCHDHLTLSV---SRPEGRSWPSAPDDSKAQAHRIHIDPEIQDG------ 111
THLEAQN+IK +L+L++ RP S + P + DP +
Sbjct: 61 THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP 120
Query: 112 SPTTSRRPSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSAD 171
SP+ R S G + RP+ + +P F + +EA+ P PP ++
Sbjct: 121 SPSPEARASPGTPGTPELRPTFSPAFSRPSAF----SSLAEASDP--------GPPRASL 168
Query: 172 PARGLPR-SRDC---RVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWP 227
A+ P +RD + GS R P +AE + + Y + G+
Sbjct: 169 RAKTSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSL--RGKASGVG 226
Query: 228 GPGGPRNLKPTASKLGAPL 246
PGG +K A +P+
Sbjct: 227 LPGGSLPIKDLAVDSASPV 245
>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
Length = 727
Score = 108 bits (269), Expect = 9e-24
Identities = 86/259 (33%), Positives = 124/259 (47%), Gaps = 27/259 (10%)
Query: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
M +SVTL GP PWGFRL GG+DF+ PLTISR+ GSKAA + L GDL+ AI+G +T+ M
Sbjct: 1 MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60
Query: 61 THLEAQNRIKGCHDHLTLSV---SRPEGRSWPSAPDDSKAQAHRIHIDPEIQDG------ 111
THLEAQN+IK +L+L++ RP S + P + DP +
Sbjct: 61 THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP 120
Query: 112 SPTTSRRPSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSAD 171
SP+ R S G + RP+ + +P F + +EA+ P PP ++
Sbjct: 121 SPSPEARASPGTPGTPELRPTFSPAFSRPSAF----SSLAEASDP--------GPPRASL 168
Query: 172 PARGLPR-SRDC---RVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWP 227
A+ P +RD + GS R P +AE + + Y + G+
Sbjct: 169 RAKTSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSL--RGKASGVG 226
Query: 228 GPGGPRNLKPTASKLGAPL 246
PGG +K A +P+
Sbjct: 227 LPGGSLPIKDLAVDSASPV 245
Score = 41.6 bits (96), Expect = 0.001
Identities = 53/229 (23%), Positives = 75/229 (32%), Gaps = 31/229 (13%)
Query: 89 PSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPS-GTGTGPEDGRPSLGSPYGQPPRFPVPH 147
P+AP I P + P ++ PS G P PS Y P P
Sbjct: 388 PAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSPAPAYTPSPA-PAYT 446
Query: 148 NGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEP-- 205
P+ SP P+ +PA + S PAEP + P
Sbjct: 447 PSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGG---------------PAEPASRPPWV 491
Query: 206 -KQSGSFRYLQGMLEAG-------EGGDWPGPGGPRNLKPTAS---KLGAPLSGLQGLPE 254
S S ++ G GG P GP+ + P A + P
Sbjct: 492 TDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQ-VPPLARGTVQRAERFPASSRTPL 550
Query: 255 CTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCE 303
C C + I G + A + +HPE F C+ C +L + +YCE
Sbjct: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCE 599
Score = 36.2 bits (82), Expect = 0.041
Identities = 15/51 (29%), Positives = 24/51 (47%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCE 303
P C +C I+G ++ A + +H CF+C+ C + D YCE
Sbjct: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCE 658
Score = 33.9 bits (76), Expect = 0.21
Identities = 12/40 (30%), Positives = 24/40 (60%)
Query: 267 VKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHA 306
++A +H CF+C+ C +NL+ + ++ +R C+ HA
Sbjct: 683 IEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 722
>gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]
Length = 487
Score = 103 bits (256), Expect = 3e-22
Identities = 98/356 (27%), Positives = 138/356 (38%), Gaps = 55/356 (15%)
Query: 3 HSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTH 62
+SV+L GP+PWGFRL GG+DF+ PLTIS + G KAA A + GD++ +I+G + + MTH
Sbjct: 4 YSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTH 63
Query: 63 LEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRI--HIDPEIQDGSPTTSRRPS 120
LEAQN+IKGC L +++ R P K + E+ +G S+ S
Sbjct: 64 LEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKPTVTSVCSETSQELAEGQRRGSQGDS 123
Query: 121 GTGTGP------------------------------EDGRPSLGSPYGQPPRF-----PV 145
GP ED RP G+ + R
Sbjct: 124 KQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGT 183
Query: 146 PHNGSSEATLPAQMSTLHVSPP---PSADPARGLPRSRDCRVDLGSEVYRMLREPA-EPV 201
H SEA + + P S R +P S D V + A +PV
Sbjct: 184 EHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPV 243
Query: 202 AAEP--KQSGSFRYLQGMLEAG---EGGDWPGPGGPRNL---------KPTASKLGAPLS 247
+ K R QG+ G + G P N + T + +
Sbjct: 244 GSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIP 303
Query: 248 GLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCE 303
+ P C C I G + A K +HPE F C+ C + G+ LYCE
Sbjct: 304 AGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCE 359
Score = 46.6 bits (109), Expect = 3e-05
Identities = 18/52 (34%), Positives = 28/52 (53%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCES 304
PEC RC I+G ++ A + +H CF+C CG ++ + D YCE+
Sbjct: 368 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCET 419
Score = 30.8 bits (68), Expect = 1.7
Identities = 18/70 (25%), Positives = 31/70 (44%), Gaps = 14/70 (20%)
Query: 251 GLPECTRCGHGIVGTI--------------VKARDKLYHPECFMCSDCGLNLKQRGYFFL 296
G P C + + GTI ++A +H CF+CS C +L+ + +F
Sbjct: 413 GEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSK 472
Query: 297 DERLYCESHA 306
++ C+ HA
Sbjct: 473 KDKPLCKKHA 482
>gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]
Length = 283
Score = 100 bits (250), Expect = 1e-21
Identities = 48/82 (58%), Positives = 63/82 (76%)
Query: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
M +SVTL GP PWGFRL GG+DF+ PLTISR+ GSKAA + L GDL+ AI+G +T+ M
Sbjct: 1 MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60
Query: 61 THLEAQNRIKGCHDHLTLSVSR 82
THLEAQN+IK +L+L++ +
Sbjct: 61 THLEAQNKIKSASYNLSLTLQK 82
>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
Length = 617
Score = 100 bits (250), Expect = 1e-21
Identities = 48/82 (58%), Positives = 63/82 (76%)
Query: 1 MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELM 60
M +SVTL GP PWGFRL GG+DF+ PLTISR+ GSKAA + L GDL+ AI+G +T+ M
Sbjct: 1 MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60
Query: 61 THLEAQNRIKGCHDHLTLSVSR 82
THLEAQN+IK +L+L++ +
Sbjct: 61 THLEAQNKIKSASYNLSLTLQK 82
Score = 42.0 bits (97), Expect = 8e-04
Identities = 64/250 (25%), Positives = 86/250 (34%), Gaps = 24/250 (9%)
Query: 74 DHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSP------TTSRRPSGTGTGPE 127
D L SRP+ S+ A S A A +P T S RPS P
Sbjct: 244 DEEALRRSRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPA 303
Query: 128 DG-RPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDL 186
PS G+ Y P P P + + PA + + PS PA P
Sbjct: 304 STYSPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAY-TPSPAPNYNPA 362
Query: 187 GSEVYRMLREPAEPVAAEP---KQSGSFRYLQGMLEAG-------EGGDWPGPGGPRNLK 236
S Y PAEP + P S S ++ G GG P GP+ +
Sbjct: 363 PSVAYS--GGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQ-VP 419
Query: 237 PTAS---KLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGY 293
P A + P C C + I G + A + +HPE F C+ C +L +
Sbjct: 420 PLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCF 479
Query: 294 FFLDERLYCE 303
+YCE
Sbjct: 480 VEEQNNVYCE 489
Score = 36.2 bits (82), Expect = 0.041
Identities = 15/51 (29%), Positives = 24/51 (47%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCE 303
P C +C I+G ++ A + +H CF+C+ C + D YCE
Sbjct: 498 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCE 548
Score = 33.9 bits (76), Expect = 0.21
Identities = 12/40 (30%), Positives = 24/40 (60%)
Query: 267 VKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHA 306
++A +H CF+C+ C +NL+ + ++ +R C+ HA
Sbjct: 573 IEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 612
>gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens]
Length = 222
Score = 97.8 bits (242), Expect = 1e-20
Identities = 58/143 (40%), Positives = 79/143 (55%), Gaps = 8/143 (5%)
Query: 5 VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64
V L GP+PWGFRL GG+DF+ PL+ISR+ G KAA A + GD + +I+GE+ +TH+E
Sbjct: 6 VVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIE 65
Query: 65 AQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQ-AHRIHIDPEIQDGSPTTSRRPSGTG 123
AQN+I+ C + L+L +SR + P SK Q A DP +P+ S +
Sbjct: 66 AQNKIRACGERLSLGLSRAQ-------PVQSKPQKASAPAADPPRYTFAPSVSLNKTARP 118
Query: 124 TGPEDGRPSLGSPYGQPPRFPVP 146
G S GQP R VP
Sbjct: 119 FGAPPPADSAPQQNGQPLRPLVP 141
>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
Length = 596
Score = 97.1 bits (240), Expect = 2e-20
Identities = 77/242 (31%), Positives = 107/242 (44%), Gaps = 16/242 (6%)
Query: 3 HSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTH 62
+SV+L GP+PWGFRL GG+DF+ PLTIS + G KAA A + GD++ +I+G + + MTH
Sbjct: 4 YSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTH 63
Query: 63 LEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPSGT 122
LEAQN+IKGC L +++ R P K + + + P + SP S+ S
Sbjct: 64 LEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEV-VKP-VPITSPAVSKVTSTN 121
Query: 123 GTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMST-LHVSPPPSAD------PARG 175
GS P +P S A PA +T H SP P A A G
Sbjct: 122 NMAYNKAPRPFGS-VSSPKVTSIP--SPSSAFTPAHATTSSHASPSPVAAVTPPLFAASG 178
Query: 176 LPRSRDCRVDLG----SEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGG 231
L + + D S + P +P S +G +G G
Sbjct: 179 LHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGP 238
Query: 232 PR 233
PR
Sbjct: 239 PR 240
Score = 46.6 bits (109), Expect = 3e-05
Identities = 18/52 (34%), Positives = 28/52 (53%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCES 304
PEC RC I+G ++ A + +H CF+C CG ++ + D YCE+
Sbjct: 477 PECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCET 528
Score = 37.0 bits (84), Expect = 0.024
Identities = 18/51 (35%), Positives = 23/51 (45%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCE 303
P C C I G + A K +HPE F C+ C + G+ LYCE
Sbjct: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCE 468
Score = 30.8 bits (68), Expect = 1.7
Identities = 18/70 (25%), Positives = 31/70 (44%), Gaps = 14/70 (20%)
Query: 251 GLPECTRCGHGIVGTI--------------VKARDKLYHPECFMCSDCGLNLKQRGYFFL 296
G P C + + GTI ++A +H CF+CS C +L+ + +F
Sbjct: 522 GEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSK 581
Query: 297 DERLYCESHA 306
++ C+ HA
Sbjct: 582 KDKPLCKKHA 591
>gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]
Length = 214
Score = 91.7 bits (226), Expect = 8e-19
Identities = 47/97 (48%), Positives = 64/97 (65%), Gaps = 1/97 (1%)
Query: 3 HSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTH 62
+SV+L GP+PWGFRL GG+DF+ PLTIS + G KAA A + GD++ +I+G + + MTH
Sbjct: 4 YSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTH 63
Query: 63 LEAQNRIKGCHDHLTLSVSRPEGRSWPS-APDDSKAQ 98
LEAQN+IKGC L +++ R P P K Q
Sbjct: 64 LEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKKTQ 100
>gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]
Length = 234
Score = 91.3 bits (225), Expect = 1e-18
Identities = 55/142 (38%), Positives = 80/142 (56%), Gaps = 10/142 (7%)
Query: 3 HSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTH 62
+SV+L GP+PWGFRL GG+DF+ PLTIS + G KAA A + GD++ +I+G + + MTH
Sbjct: 4 YSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTH 63
Query: 63 LEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRI--HIDPEIQDGSPTTSRRPS 120
LEAQN+IKGC L +++ R P K + E+ +G RR S
Sbjct: 64 LEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKPTVTSVCSETSQELAEG----QRRGS 119
Query: 121 GTGTGPEDGRPSLGSPYGQPPR 142
+ ++G+ P +PPR
Sbjct: 120 QGDSKQQNGK----IPPKRPPR 137
>gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
Length = 977
Score = 65.5 bits (158), Expect = 6e-11
Identities = 56/184 (30%), Positives = 82/184 (44%), Gaps = 14/184 (7%)
Query: 5 VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64
VTL G +PWGFRL GG + PL +S++ S+A A L D + AING S ++H
Sbjct: 9 VTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTNLSHAS 68
Query: 65 AQNRIKGCHDHLTLSVSR--PEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPSGT 122
A + I + L L+V R EG +P + + + + PE G+P G+
Sbjct: 69 AMSLIDASGNQLVLTVQRLADEGPVQSPSPHELQVLSPLSPLSPE-PPGAPVPQPLQPGS 127
Query: 123 GTGPEDGRPSLGSPYG--------QPPRFPVPHNGSSEATLP-AQMSTLHVSPPPSADPA 173
P D G + PR P G + T P A +++S P A+PA
Sbjct: 128 LRSPPDSEAYYGETDSDADGPATQEKPRRP-RRRGPTRPTPPGAPPDEVYLSDSP-AEPA 185
Query: 174 RGLP 177
+P
Sbjct: 186 PTIP 189
>gi|193083191 synaptopodin 2 isoform c [Homo sapiens]
Length = 1109
Score = 60.5 bits (145), Expect = 2e-09
Identities = 27/79 (34%), Positives = 47/79 (59%)
Query: 5 VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64
+++ G +PWGFRL GG++ PL ++++ SKA+ + LC GD + +ING +T+ E
Sbjct: 9 ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
Query: 65 AQNRIKGCHDHLTLSVSRP 83
++ D L + + RP
Sbjct: 69 VIKLMESITDSLQMLIKRP 87
>gi|193083185 synaptopodin 2 isoform b [Homo sapiens]
Length = 1093
Score = 60.5 bits (145), Expect = 2e-09
Identities = 27/79 (34%), Positives = 47/79 (59%)
Query: 5 VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64
+++ G +PWGFRL GG++ PL ++++ SKA+ + LC GD + +ING +T+ E
Sbjct: 9 ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
Query: 65 AQNRIKGCHDHLTLSVSRP 83
++ D L + + RP
Sbjct: 69 VIKLMESITDSLQMLIKRP 87
>gi|193083183 synaptopodin 2 isoform a [Homo sapiens]
Length = 1261
Score = 60.5 bits (145), Expect = 2e-09
Identities = 27/79 (34%), Positives = 47/79 (59%)
Query: 5 VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64
+++ G +PWGFRL GG++ PL ++++ SKA+ + LC GD + +ING +T+ E
Sbjct: 9 ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
Query: 65 AQNRIKGCHDHLTLSVSRP 83
++ D L + + RP
Sbjct: 69 VIKLMESITDSLQMLIKRP 87
>gi|122937269 Wilms tumor 1 interacting protein [Homo sapiens]
Length = 430
Score = 56.2 bits (134), Expect = 4e-08
Identities = 52/198 (26%), Positives = 73/198 (36%), Gaps = 14/198 (7%)
Query: 111 GSPTTSRRPSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSA 170
GSP S S G G R S G G R P +G S+ P PPS
Sbjct: 87 GSPRASLAGSDGGGGGGSARSS-GISLGYDQRHGSPRSGRSDPR-PGP-------GPPSV 137
Query: 171 DPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPG 230
AR S R G+ + A P+ +G + L G +
Sbjct: 138 GSARSSVSSLGSRGSAGAYADFLPPGACPAPARSPEPAGPAPFPLPALPLPPGREGGPSA 197
Query: 231 GPRNLKPTASKLGAPLSGLQGLPE---CTRCGHGIVGT--IVKARDKLYHPECFMCSDCG 285
R L+ +L L C +CG GI G +A LYH +CF C CG
Sbjct: 198 AERRLEALTRELERALEARTARDYFGICIKCGLGIYGAQQACQAMGSLYHTDCFTCDSCG 257
Query: 286 LNLKQRGYFFLDERLYCE 303
L+ + ++ + E++YC+
Sbjct: 258 RRLRGKAFYNVGEKVYCQ 275
Score = 40.4 bits (93), Expect = 0.002
Identities = 17/35 (48%), Positives = 22/35 (62%)
Query: 250 QGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDC 284
Q +C+ CGH I+ I++A K YHP CF CS C
Sbjct: 285 QTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVC 319
Score = 33.1 bits (74), Expect = 0.35
Identities = 23/70 (32%), Positives = 32/70 (45%), Gaps = 10/70 (14%)
Query: 253 PECTRCGHGIVG------TI-VKARDKLYHPECFMCSDCGLNL---KQRGYFFLDERLYC 302
P+C C I+ TI V + D+ YH C+ C DCGL L + R + L L C
Sbjct: 348 PKCASCARPILPAQGCETTIRVVSMDRDYHVACYHCEDCGLQLSGEEGRRCYPLAGHLLC 407
Query: 303 ESHAKARVKP 312
R++P
Sbjct: 408 RRCHLRRLQP 417
>gi|170932518 paxillin isoform 3 [Homo sapiens]
Length = 424
Score = 55.8 bits (133), Expect = 5e-08
Identities = 56/202 (27%), Positives = 84/202 (41%), Gaps = 36/202 (17%)
Query: 113 PTTSRRPSGTG-TGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSAD 171
P T +P G G ED RPS+ S + E+++P+ + + V+ +
Sbjct: 63 PLTKEKPKRNGGRGLEDVRPSVESLLDE-----------LESSVPSPVPAITVNQGEMSS 111
Query: 172 PARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGG 231
P R + R+ S RE E +A+ F+++ G+ G PGG
Sbjct: 112 PQRVTSTQQQTRISASSAT----RELDELMAS----LSDFKFMA----QGKTGSSSPPGG 159
Query: 232 PRNLKPTA---SKLGAPLSGLQGLPE-------CTRCGHGIVGTIVKARDKLYHPECFMC 281
P KP + S LG+ S L L C C I G +V A K +HPE F+C
Sbjct: 160 PP--KPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVC 217
Query: 282 SDCGLNLKQRGYFFLDERLYCE 303
+ C + R +F D + YCE
Sbjct: 218 THCQEEIGSRNFFERDGQPYCE 239
Score = 48.1 bits (113), Expect = 1e-05
Identities = 20/57 (35%), Positives = 29/57 (50%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHAKAR 309
P+C C I+ + A + L+HPECF+C +C +F D + YCE H R
Sbjct: 307 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHER 363
Score = 43.9 bits (102), Expect = 2e-04
Identities = 18/50 (36%), Positives = 25/50 (50%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYC 302
P C C I+ +V A D+ +HPE F C+ CG G+ D + YC
Sbjct: 248 PRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYC 297
Score = 35.4 bits (80), Expect = 0.071
Identities = 15/50 (30%), Positives = 27/50 (54%)
Query: 255 CTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCES 304
C+ C I G + A K +HPE F+C+ C L + + +++ YC++
Sbjct: 368 CSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQN 417
>gi|170932516 paxillin isoform 2 [Homo sapiens]
Length = 557
Score = 55.8 bits (133), Expect = 5e-08
Identities = 56/202 (27%), Positives = 84/202 (41%), Gaps = 36/202 (17%)
Query: 113 PTTSRRPSGTG-TGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSAD 171
P T +P G G ED RPS+ S + E+++P+ + + V+ +
Sbjct: 196 PLTKEKPKRNGGRGLEDVRPSVESLLDE-----------LESSVPSPVPAITVNQGEMSS 244
Query: 172 PARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGG 231
P R + R+ S RE E +A+ F+++ G+ G PGG
Sbjct: 245 PQRVTSTQQQTRISASSAT----RELDELMAS----LSDFKFMA----QGKTGSSSPPGG 292
Query: 232 PRNLKPTA---SKLGAPLSGLQGLPE-------CTRCGHGIVGTIVKARDKLYHPECFMC 281
P KP + S LG+ S L L C C I G +V A K +HPE F+C
Sbjct: 293 PP--KPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVC 350
Query: 282 SDCGLNLKQRGYFFLDERLYCE 303
+ C + R +F D + YCE
Sbjct: 351 THCQEEIGSRNFFERDGQPYCE 372
Score = 48.1 bits (113), Expect = 1e-05
Identities = 20/57 (35%), Positives = 29/57 (50%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHAKAR 309
P+C C I+ + A + L+HPECF+C +C +F D + YCE H R
Sbjct: 440 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHER 496
Score = 43.9 bits (102), Expect = 2e-04
Identities = 18/50 (36%), Positives = 25/50 (50%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYC 302
P C C I+ +V A D+ +HPE F C+ CG G+ D + YC
Sbjct: 381 PRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYC 430
Score = 35.4 bits (80), Expect = 0.071
Identities = 15/50 (30%), Positives = 27/50 (54%)
Query: 255 CTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCES 304
C+ C I G + A K +HPE F+C+ C L + + +++ YC++
Sbjct: 501 CSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQN 550
>gi|91208423 thyroid receptor-interacting protein 6 [Homo sapiens]
Length = 476
Score = 55.1 bits (131), Expect = 9e-08
Identities = 63/234 (26%), Positives = 91/234 (38%), Gaps = 47/234 (20%)
Query: 107 EIQDGSPTTSRRPSGTG----------TG---PEDGRPSLGSPYGQPPRFPVPHNGSSEA 153
E+ G SRRP TG P P SPYG P P + +S
Sbjct: 106 ELNGGRGHASRRPDRQAYEPPPPPAYRTGSLKPNPASPLPASPYGGPT--PASYTTASTP 163
Query: 154 TLPAQMSTLHVSPPPSA--DPARGLPRSRDC----------RVDLGSEVYRMLREPAEPV 201
PA + V+ P P RG ++ R ++ YR REP
Sbjct: 164 AGPAFPVQVKVAQPVRGCGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRSQREPGP-- 221
Query: 202 AAEPKQSGSFRYLQGMLEAGEGGDWPGPGGP----------RNLKPTASKLGAPLSGLQG 251
A+ + +G + G G GG+ GP P R K + P SG +
Sbjct: 222 GAKEEAAG----VSGPAGRGRGGEH-GPQVPLSQPPEDELDRLTKKLVHDMNHPPSG-EY 275
Query: 252 LPECTRCGHGIVG--TIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCE 303
+C CG +VG V A D+++H CF+CS C L+ + ++ ++ R YCE
Sbjct: 276 FGQCGGCGEDVVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCE 329
Score = 36.2 bits (82), Expect = 0.041
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 252 LPECTRCGHGIVGTIVKARDKLYHPECFMCSDC 284
L +C C I+ I++A K YHP CF C C
Sbjct: 336 LEKCATCSQPILDRILRAMGKAYHPGCFTCVVC 368
Score = 34.7 bits (78), Expect = 0.12
Identities = 19/70 (27%), Positives = 34/70 (48%), Gaps = 11/70 (15%)
Query: 253 PECTRCGHGIVG-------TIVKARDKLYHPECFMCSDCGLNLKQ----RGYFFLDERLY 301
P C+ CG I+ + A D+ +H C+ C +CGL L +G + LD +
Sbjct: 397 PRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHIL 456
Query: 302 CESHAKARVK 311
C++ + R++
Sbjct: 457 CKACSAWRIQ 466
>gi|4502175 apical protein of Xenopus-like [Homo sapiens]
Length = 1616
Score = 53.5 bits (127), Expect = 3e-07
Identities = 35/85 (41%), Positives = 42/85 (49%), Gaps = 2/85 (2%)
Query: 5 VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSK-AALAALCPGDLIQAINGESTELMTHL 63
V L G +PWGF L GGR+ PL I+++ GSK AA+ L GD I IN
Sbjct: 29 VQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQ- 87
Query: 64 EAQNRIKGCHDHLTLSVSRPEGRSW 88
EA +KG H L L V R W
Sbjct: 88 EAICLVKGSHKTLKLVVKRRSELGW 112
Score = 29.3 bits (64), Expect = 5.1
Identities = 37/129 (28%), Positives = 47/129 (36%), Gaps = 19/129 (14%)
Query: 162 LHVSPPPSADP------ARGLPRSRDCRVDLGSEVYRMLREPAEP-------VAAEPKQS 208
L VS P P +R P + + + E+ R +P EP V AE QS
Sbjct: 902 LDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQS 961
Query: 209 GSFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVK 268
+ E G P PT S+L S +G PE R G G GT+
Sbjct: 962 TPRQADAQCREGSPGSQQHPPSQKAPNPPTFSEL----SHCRGAPELPREGRGRAGTL-- 1015
Query: 269 ARDKLYHPE 277
RD Y E
Sbjct: 1016 PRDYRYSEE 1024
>gi|221316659 leupaxin isoform 1 [Homo sapiens]
Length = 391
Score = 53.1 bits (126), Expect = 3e-07
Identities = 20/53 (37%), Positives = 30/53 (56%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESH 305
P+C C ++ + A D ++HPECF+C DC + +F LD R +CE H
Sbjct: 273 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELH 325
Score = 43.9 bits (102), Expect = 2e-04
Identities = 20/63 (31%), Positives = 29/63 (46%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHAKARVKP 312
P C C I+ ++ A ++ +HPE F CS CG G+ D++ YC A P
Sbjct: 214 PRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSP 273
Query: 313 PEG 315
G
Sbjct: 274 KCG 276
Score = 35.8 bits (81), Expect = 0.054
Identities = 15/49 (30%), Positives = 25/49 (51%)
Query: 255 CTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCE 303
C CG I G + A +HPE F+C+ C L + + +++ YC+
Sbjct: 334 CHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQ 382
Score = 34.7 bits (78), Expect = 0.12
Identities = 16/57 (28%), Positives = 27/57 (47%), Gaps = 2/57 (3%)
Query: 248 GLQGLPE--CTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYC 302
G+ +P+ C C I G ++ A + +HPE F+C+ C + +F YC
Sbjct: 148 GIATVPKGHCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYC 204
>gi|4758670 leupaxin isoform 2 [Homo sapiens]
Length = 386
Score = 53.1 bits (126), Expect = 3e-07
Identities = 20/53 (37%), Positives = 30/53 (56%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESH 305
P+C C ++ + A D ++HPECF+C DC + +F LD R +CE H
Sbjct: 268 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELH 320
Score = 43.9 bits (102), Expect = 2e-04
Identities = 20/63 (31%), Positives = 29/63 (46%)
Query: 253 PECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHAKARVKP 312
P C C I+ ++ A ++ +HPE F CS CG G+ D++ YC A P
Sbjct: 209 PRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSP 268
Query: 313 PEG 315
G
Sbjct: 269 KCG 271
Score = 35.8 bits (81), Expect = 0.054
Identities = 15/49 (30%), Positives = 25/49 (51%)
Query: 255 CTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCE 303
C CG I G + A +HPE F+C+ C L + + +++ YC+
Sbjct: 329 CHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQ 377
Score = 34.7 bits (78), Expect = 0.12
Identities = 16/57 (28%), Positives = 27/57 (47%), Gaps = 2/57 (3%)
Query: 248 GLQGLPE--CTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYC 302
G+ +P+ C C I G ++ A + +HPE F+C+ C + +F YC
Sbjct: 143 GIATVPKGHCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYC 199
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.136 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,882,160
Number of Sequences: 37866
Number of extensions: 1057728
Number of successful extensions: 6166
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 198
Number of HSP's successfully gapped in prelim test: 411
Number of HSP's that attempted gapping in prelim test: 5191
Number of HSP's gapped (non-prelim): 1391
length of query: 330
length of database: 18,247,518
effective HSP length: 103
effective length of query: 227
effective length of database: 14,347,320
effective search space: 3256841640
effective search space used: 3256841640
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.