Guide to the Human Genome
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Search of human proteins with 193083185

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|193083185 synaptopodin 2 isoform b [Homo sapiens]
         (1093 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|193083185 synaptopodin 2 isoform b [Homo sapiens]                 2180   0.0  
gi|193083191 synaptopodin 2 isoform c [Homo sapiens]                 2163   0.0  
gi|193083183 synaptopodin 2 isoform a [Homo sapiens]                 2162   0.0  
gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]             349   9e-96
gi|50301232 synaptopodin 2-like isoform b [Homo sapiens]              345   1e-94
gi|158303333 synaptopodin isoform B [Homo sapiens]                    112   2e-24
gi|40353727 synaptopodin isoform A [Homo sapiens]                     100   6e-21
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]             74   1e-12
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    71   5e-12
gi|13994151 PDZ and LIM domain 1 [Homo sapiens]                        71   5e-12
gi|163965366 nascent polypeptide-associated complex alpha subuni...    71   5e-12
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    69   2e-11
gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]             69   2e-11
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    66   2e-10
gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]              65   3e-10
gi|47132519 Ras association and pleckstrin homology domains 1 is...    65   3e-10
gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens]             65   5e-10
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]              65   5e-10
gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]              65   5e-10
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]             65   5e-10
gi|222352122 hypothetical protein LOC284297 [Homo sapiens]             64   1e-09
gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]             62   3e-09
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]             62   3e-09
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]        62   4e-09
gi|118600967 shroom family member 4 [Homo sapiens]                     61   7e-09
gi|196162711 PDZ and LIM domain 4 isoform 2 [Homo sapiens]             60   9e-09
gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens]              60   9e-09
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    60   9e-09
gi|150418009 transforming, acidic coiled-coil containing protein...    60   1e-08
gi|45827755 transforming, acidic coiled-coil containing protein ...    60   1e-08

>gi|193083185 synaptopodin 2 isoform b [Homo sapiens]
          Length = 1093

 Score = 2180 bits (5650), Expect = 0.0
 Identities = 1093/1093 (100%), Positives = 1093/1093 (100%)

Query: 1    MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP 60
            MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP
Sbjct: 1    MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP 60

Query: 61   CADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQI 120
            CADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQI
Sbjct: 61   CADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQI 120

Query: 121  RPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAE 180
            RPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAE
Sbjct: 121  RPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAE 180

Query: 181  ELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVH 240
            ELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVH
Sbjct: 181  ELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVH 240

Query: 241  INSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCR 300
            INSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCR
Sbjct: 241  INSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCR 300

Query: 301  LQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTEQGEDPRSEKDHSRPHKHRARHARLRR 360
            LQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTEQGEDPRSEKDHSRPHKHRARHARLRR
Sbjct: 301  LQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTEQGEDPRSEKDHSRPHKHRARHARLRR 360

Query: 361  SESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELERE 420
            SESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELERE
Sbjct: 361  SESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELERE 420

Query: 421  ADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDK 480
            ADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDK
Sbjct: 421  ADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDK 480

Query: 481  MEMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKE 540
            MEMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKE
Sbjct: 481  MEMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKE 540

Query: 541  EESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPA 600
            EESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPA
Sbjct: 541  EESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPA 600

Query: 601  TPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAF 660
            TPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAF
Sbjct: 601  TPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAF 660

Query: 661  YDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGK 720
            YDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGK
Sbjct: 661  YDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGK 720

Query: 721  RGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVW 780
            RGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVW
Sbjct: 721  RGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVW 780

Query: 781  SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNY 840
            SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNY
Sbjct: 781  SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNY 840

Query: 841  TPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARA 900
            TPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARA
Sbjct: 841  TPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARA 900

Query: 901  QSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLN 960
            QSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLN
Sbjct: 901  QSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLN 960

Query: 961  ALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQ 1020
            ALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQ
Sbjct: 961  ALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQ 1020

Query: 1021 ASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSG 1080
            ASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSG
Sbjct: 1021 ASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSG 1080

Query: 1081 VTIQVWKPSVVEE 1093
            VTIQVWKPSVVEE
Sbjct: 1081 VTIQVWKPSVVEE 1093


>gi|193083191 synaptopodin 2 isoform c [Homo sapiens]
          Length = 1109

 Score = 2163 bits (5605), Expect = 0.0
 Identities = 1085/1085 (100%), Positives = 1085/1085 (100%)

Query: 1    MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP 60
            MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP
Sbjct: 1    MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP 60

Query: 61   CADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQI 120
            CADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQI
Sbjct: 61   CADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQI 120

Query: 121  RPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAE 180
            RPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAE
Sbjct: 121  RPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAE 180

Query: 181  ELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVH 240
            ELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVH
Sbjct: 181  ELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVH 240

Query: 241  INSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCR 300
            INSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCR
Sbjct: 241  INSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCR 300

Query: 301  LQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTEQGEDPRSEKDHSRPHKHRARHARLRR 360
            LQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTEQGEDPRSEKDHSRPHKHRARHARLRR
Sbjct: 301  LQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTEQGEDPRSEKDHSRPHKHRARHARLRR 360

Query: 361  SESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELERE 420
            SESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELERE
Sbjct: 361  SESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELERE 420

Query: 421  ADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDK 480
            ADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDK
Sbjct: 421  ADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDK 480

Query: 481  MEMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKE 540
            MEMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKE
Sbjct: 481  MEMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKE 540

Query: 541  EESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPA 600
            EESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPA
Sbjct: 541  EESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPA 600

Query: 601  TPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAF 660
            TPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAF
Sbjct: 601  TPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAF 660

Query: 661  YDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGK 720
            YDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGK
Sbjct: 661  YDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGK 720

Query: 721  RGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVW 780
            RGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVW
Sbjct: 721  RGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVW 780

Query: 781  SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNY 840
            SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNY
Sbjct: 781  SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNY 840

Query: 841  TPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARA 900
            TPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARA
Sbjct: 841  TPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARA 900

Query: 901  QSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLN 960
            QSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLN
Sbjct: 901  QSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLN 960

Query: 961  ALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQ 1020
            ALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQ
Sbjct: 961  ALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQ 1020

Query: 1021 ASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSG 1080
            ASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSG
Sbjct: 1021 ASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSG 1080

Query: 1081 VTIQV 1085
            VTIQV
Sbjct: 1081 VTIQV 1085


>gi|193083183 synaptopodin 2 isoform a [Homo sapiens]
          Length = 1261

 Score = 2162 bits (5601), Expect = 0.0
 Identities = 1084/1084 (100%), Positives = 1084/1084 (100%)

Query: 1    MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP 60
            MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP
Sbjct: 1    MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP 60

Query: 61   CADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQI 120
            CADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQI
Sbjct: 61   CADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQI 120

Query: 121  RPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAE 180
            RPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAE
Sbjct: 121  RPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAE 180

Query: 181  ELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVH 240
            ELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVH
Sbjct: 181  ELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVH 240

Query: 241  INSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCR 300
            INSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCR
Sbjct: 241  INSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCR 300

Query: 301  LQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTEQGEDPRSEKDHSRPHKHRARHARLRR 360
            LQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTEQGEDPRSEKDHSRPHKHRARHARLRR
Sbjct: 301  LQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTEQGEDPRSEKDHSRPHKHRARHARLRR 360

Query: 361  SESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELERE 420
            SESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELERE
Sbjct: 361  SESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELERE 420

Query: 421  ADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDK 480
            ADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDK
Sbjct: 421  ADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDK 480

Query: 481  MEMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKE 540
            MEMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKE
Sbjct: 481  MEMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKE 540

Query: 541  EESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPA 600
            EESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPA
Sbjct: 541  EESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPA 600

Query: 601  TPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAF 660
            TPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAF
Sbjct: 601  TPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAF 660

Query: 661  YDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGK 720
            YDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGK
Sbjct: 661  YDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGK 720

Query: 721  RGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVW 780
            RGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVW
Sbjct: 721  RGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVW 780

Query: 781  SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNY 840
            SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNY
Sbjct: 781  SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNY 840

Query: 841  TPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARA 900
            TPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARA
Sbjct: 841  TPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARA 900

Query: 901  QSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLN 960
            QSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLN
Sbjct: 901  QSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLN 960

Query: 961  ALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQ 1020
            ALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQ
Sbjct: 961  ALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQ 1020

Query: 1021 ASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSG 1080
            ASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSG
Sbjct: 1021 ASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSG 1080

Query: 1081 VTIQ 1084
            VTIQ
Sbjct: 1081 VTIQ 1084


>gi|166706868 synaptopodin 2-like isoform a [Homo sapiens]
          Length = 977

 Score =  349 bits (895), Expect = 9e-96
 Identities = 290/832 (34%), Positives = 389/832 (46%), Gaps = 189/832 (22%)

Query: 343  KDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRR 402
            +D +  +  +A+ A+L+R+ESL EK +KEAK+KC++IA LLT APNP+SKGVLMFKKRR+
Sbjct: 244  EDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQ 303

Query: 403  RARKYTLVSYGTGELEREADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNF 462
            RA+KYTLVS+G         EEE+G             SESE+DEE  SD    T     
Sbjct: 304  RAKKYTLVSFGAA--AGTGAEEEDGVPP---------TSESELDEEAFSDARSLTN--QS 350

Query: 463  DWDSGLVDIE-----KKLNRGDKMEM---LPDTTGKGALMFAKRRERMDQITAQKEEDKV 514
            DWDS  +D+E      + + G    +   L + +G+G  +F ++R+R D  T +      
Sbjct: 351  DWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQEL----- 405

Query: 515  GGTPSREQDAAQT--DGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSG 572
                +R + AA    +GL++    Q    E+     S   + +         P Q G   
Sbjct: 406  ----ARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPR-----PFQPGGGA 456

Query: 573  TSETANIQRMVPMNRTAKPF-PGSVNQPAT-------PFSPTRNMTSPIADFPAPPPY-S 623
             +   +I      NR+A+PF PG   Q  T       P +P R   S     PAPPP+ S
Sbjct: 457  PTPAPSI-----FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLS 511

Query: 624  AVTPPP-DAFSRGVSS--PIAGPAQPP--------------PWPQ-----------PAPW 655
            +  P P  +F+ GV S  P++G    P              P P            PAP 
Sbjct: 512  SQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPP 571

Query: 656  SQPAFYDSS------------------------ERIASRDERISVPAKRTGILQEAKRRS 691
            S  A   ++                        E  ++R++RISVPA RTGILQEA+RR 
Sbjct: 572  SAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRG 631

Query: 692  TTKPMFT--FKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSS 749
            T K MF    +E K SPNPELLSL+QN + K   G G +SGPEED LSLGAEACNFMQ  
Sbjct: 632  TRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAG-GAESGPEEDALSLGAEACNFMQPV 690

Query: 750  SAKQ---------KTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKG 800
             A+          KTPPP+APK      +  P+TP +P   P VAP              
Sbjct: 691  GARSYKTLPHVTPKTPPPMAPK------TPPPMTPKTP---PPVAPK------------- 728

Query: 801  TVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVG 860
                         PP+R        G   G     AS    P+P                
Sbjct: 729  -------------PPSR--------GLLDGLVNGAASSAGIPEP---------------- 751

Query: 861  PSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQ--AHAARAQSPTPSLPASWKYSSNVR 918
                 P + GRG +LFAKRQSR ++YVV+           R+ SPTPSLP SWKYS N+R
Sbjct: 752  -----PRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIR 806

Query: 919  APPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFT 978
            APPP+AYNP+ SP +P AA     + +Q  +   K+G   + ALD M+HQPYQL  ++F 
Sbjct: 807  APPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQG---IKALDFMRHQPYQLKTAMFC 863

Query: 979  FQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFA 1038
            F       G     S K      +++   P P   A P      +  +      P     
Sbjct: 864  FDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTE 923

Query: 1039 EASSPVSASPVPVGIPTSPK--QESASSSYFVAPRPKFSAKKSGVTIQVWKP 1088
             AS+PV   P P   P +P+    S SS  F   RP+FSA ++G+   VW+P
Sbjct: 924  LASAPV---PSPAPPPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHVWRP 972



 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 36/86 (41%), Positives = 63/86 (73%)

Query: 1  MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNP 60
          MG  + + ++++GGAPWGFRL GG EQ++PLQV+KIR +S+A  +GL E D++++ING  
Sbjct: 1  MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVS 60

Query: 61 CADLTYPEVIKLMESITDSLQMLIKR 86
          C +L++   + L+++  + L + ++R
Sbjct: 61 CTNLSHASAMSLIDASGNQLVLTVQR 86



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 80/352 (22%), Positives = 124/352 (35%), Gaps = 51/352 (14%)

Query: 758  PVAPKPAVKSSSSQPVTPVS-PVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPA 816
            P  P P +    SQ  + VS P W  G A   PPA     P               + P 
Sbjct: 181  PAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLP---------------HGPL 225

Query: 817  RPASTL-NVAGPFKGPQAAVASQNYTPK-PTVSTPTVNAVQPGAVGPS-----------N 863
            RP   L  + GP   P A   +  YT K          ++Q  ++  +            
Sbjct: 226  RPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLT 285

Query: 864  ELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQS----PTPSLPASWKYSSNVRA 919
              P    +G  +F KR+ R +KY + S    A     +     PT       +  S+ R+
Sbjct: 286  AAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARS 345

Query: 920  PPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNAS---L 976
                +          LA   S+ S  Q S +G +  +     + + + Q  + ++S   L
Sbjct: 346  LTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQEL 405

Query: 977  FTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNA--ASPTNVQASSVYSVPAYTSPP 1034
               +P    +G   +S  +  SA      LPP P+ A  ASP   Q       PA    P
Sbjct: 406  ARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPA----P 461

Query: 1035 SFFAEASSPVSAS-----PVPVGI---PTSPKQESAS-SSYFVAPRPKFSAK 1077
            S F  ++ P +       P    +   P +PK+ + S      AP P  S++
Sbjct: 462  SIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQ 513


>gi|50301232 synaptopodin 2-like isoform b [Homo sapiens]
          Length = 753

 Score =  345 bits (886), Expect = 1e-94
 Identities = 291/843 (34%), Positives = 391/843 (46%), Gaps = 194/843 (23%)

Query: 337  EDPRSEKDHSR-----PHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNS 391
            ++P S+  + +     P    + +A L+R+ESL EK +KEAK+KC++IA LLT APNP+S
Sbjct: 9    QEPLSQASYDKAPDPVPELQDSFYAELQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHS 68

Query: 392  KGVLMFKKRRRRARKYTLVSYGTGELEREADEEEEGDKEDTCEVAFLGASESEVDEELLS 451
            KGVLMFKKRR+RA+KYTLVS+G         EEE+G             SESE+DEE  S
Sbjct: 69   KGVLMFKKRRQRAKKYTLVSFGAA--AGTGAEEEDGVPP---------TSESELDEEAFS 117

Query: 452  DVDDNTQVVNFDWDSGLVDIE-----KKLNRGDKMEM---LPDTTGKGALMFAKRRERMD 503
            D    T     DWDS  +D+E      + + G    +   L + +G+G  +F ++R+R D
Sbjct: 118  DARSLTN--QSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRAD 175

Query: 504  QITAQKEEDKVGGTPSREQDAAQT--DGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGL 561
              T +          +R + AA    +GL++    Q    E+     S   + +      
Sbjct: 176  SSTQEL---------ARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPR-- 224

Query: 562  GHVPQQNGFSGTSETANIQRMVPMNRTAKPF-PGSVNQPAT-------PFSPTRNMTSPI 613
               P Q G    +   +I      NR+A+PF PG   Q  T       P +P R   S  
Sbjct: 225  ---PFQPGGGAPTPAPSI-----FNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLG 276

Query: 614  ADFPAPPPY-SAVTPPP-DAFSRGVSS--PIAGPAQPP--------------PWPQ---- 651
               PAPPP+ S+  P P  +F+ GV S  P++G    P              P P     
Sbjct: 277  GLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVT 336

Query: 652  -------PAPWSQPAFYDSS------------------------ERIASRDERISVPAKR 680
                   PAP S  A   ++                        E  ++R++RISVPA R
Sbjct: 337  PGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAAR 396

Query: 681  TGILQEAKRRSTTKPMFT--FKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSL 738
            TGILQEA+RR T K MF    +E K SPNPELLSL+QN + K   G G +SGPEED LSL
Sbjct: 397  TGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAG-GAESGPEEDALSL 455

Query: 739  GAEACNFMQSSSAKQ---------KTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQP 789
            GAEACNFMQ   A+          KTPPP+APK      +  P+TP +P   P VAP   
Sbjct: 456  GAEACNFMQPVGARSYKTLPHVTPKTPPPMAPK------TPPPMTPKTP---PPVAPK-- 504

Query: 790  PAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTP 849
                                    PP+R        G   G     AS    P+P     
Sbjct: 505  ------------------------PPSR--------GLLDGLVNGAASSAGIPEP----- 527

Query: 850  TVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQ--AHAARAQSPTPSL 907
                            P + GRG +LFAKRQSR ++YVV+           R+ SPTPSL
Sbjct: 528  ----------------PRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSL 571

Query: 908  PASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKH 967
            P SWKYS N+RAPPP+AYNP+ SP +P AA     + +Q  +   K+G   + ALD M+H
Sbjct: 572  PPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQG---IKALDFMRH 628

Query: 968  QPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSV 1027
            QPYQL  ++F F       G     S K      +++   P P   A P      +  + 
Sbjct: 629  QPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAA 688

Query: 1028 PAYTSPPSFFAEASSPVSASPVPVGIPTSPK--QESASSSYFVAPRPKFSAKKSGVTIQV 1085
                 P      AS+PV   P P   P +P+    S SS  F   RP+FSA ++G+   V
Sbjct: 689  TTLDEPIWRTELASAPV---PSPAPPPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHV 745

Query: 1086 WKP 1088
            W+P
Sbjct: 746  WRP 748


>gi|158303333 synaptopodin isoform B [Homo sapiens]
          Length = 685

 Score =  112 bits (280), Expect = 2e-24
 Identities = 134/493 (27%), Positives = 201/493 (40%), Gaps = 137/493 (27%)

Query: 612  PIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRD 671
            P+ +F APP Y+             ++P+A   + PP       S    Y SS+  +S  
Sbjct: 311  PLGNFTAPPTYTETLS---------TAPLASWVRSPP-------SYSVLYPSSDPKSSHL 354

Query: 672  ERISVPAKRTGILQEAK-RRSTTKPMFTFKE-PKVSPNPELLSLLQNSEGKRGTGAGGDS 729
            +  +VPA +TGIL+E+  RR + K MFTF E PKV+PNP+LL L+Q ++ KR     G+ 
Sbjct: 355  KGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEV 414

Query: 730  GPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQP 789
            G EE+  +LGAEA NF Q  + + +  P  A +             V P W+  +   + 
Sbjct: 415  GVEEEPFALGAEASNFQQEPAPRDRASPAAAEE-------------VVPEWASCLKSPRI 461

Query: 790  PAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPK------ 843
             A P   P++    +S K A+     AR  S +         +  + S ++TP+      
Sbjct: 462  QAKPKPKPNQNLSEASGKGAELY---ARRQSRME--------KYVIESSSHTPELARCPS 510

Query: 844  PTVSTPT-----VNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAA 898
            PT+S P+      NA  PGA   ++  P  +           S    Y+ ++  ++    
Sbjct: 511  PTMSLPSSWKYPTNA--PGAFRVASRSPART--------PPASLYHGYLPENGVLR---- 556

Query: 899  RAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKP 958
                PT   P   +       P     +PI  P+      K  P AA P+K         
Sbjct: 557  --PEPTKQPPYQLR-------PSLFVLSPIKEPA------KVSPRAASPAKP-------- 593

Query: 959  LNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTN 1018
             ++LD++ + P                                 K ALPP P        
Sbjct: 594  -SSLDLVPNLP---------------------------------KGALPPSPA------- 612

Query: 1019 VQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFV--APRPKFSA 1076
            +   S  S   YTSP     ++  P + SP P G   SP   S + S     APRP FS 
Sbjct: 613  LPRPSRSSPGLYTSPGQ---DSLQPTAVSP-PYGGDISPVSPSRAWSPRAKQAPRPSFST 668

Query: 1077 KKSGVTIQVWKPS 1089
            + +G+  QVWKPS
Sbjct: 669  RNAGIEAQVWKPS 681



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 41/194 (21%), Positives = 71/194 (36%), Gaps = 26/194 (13%)

Query: 484 LPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEES 543
           L + +GKGA ++A+R+ RM++   +        TP   +  + T  L ++  Y      +
Sbjct: 473 LSEASGKGAELYARRQSRMEKYVIESSSH----TPELARCPSPTMSLPSSWKYPTNAPGA 528

Query: 544 VRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPF 603
            R            S      P  + + G          +P N   +P P    QP    
Sbjct: 529 FRV----------ASRSPARTPPASLYHG---------YLPENGVLRPEP--TKQPPYQL 567

Query: 604 SPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDS 663
            P+  + SPI +     P +A    P +     + P       P  P+P+  S P  Y S
Sbjct: 568 RPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSR-SSPGLYTS 626

Query: 664 SERIASRDERISVP 677
             + + +   +S P
Sbjct: 627 PGQDSLQPTAVSPP 640


>gi|40353727 synaptopodin isoform A [Homo sapiens]
          Length = 903

 Score =  100 bits (250), Expect = 6e-21
 Identities = 141/577 (24%), Positives = 214/577 (37%), Gaps = 151/577 (26%)

Query: 612  PIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRD 671
            P+ +F APP Y+             ++P+A   + PP       S    Y SS+  +S  
Sbjct: 311  PLGNFTAPPTYTETLS---------TAPLASWVRSPP-------SYSVLYPSSDPKSSHL 354

Query: 672  ERISVPAKRTGILQEAK-RRSTTKPMFTFKE-PKVSPNPELLSLLQNSEGKRGTGAGGDS 729
            +  +VPA +TGIL+E+  RR + K MFTF E PKV+PNP+LL L+Q ++ KR     G+ 
Sbjct: 355  KGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEV 414

Query: 730  GPEEDYLSLGAEACNFMQSSSAKQKTPPPVA-------------------PKP------- 763
            G EE+  +LGAEA NF Q  + + +  P  A                   PKP       
Sbjct: 415  GVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLS 474

Query: 764  --------------------AVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVV 803
                                 ++SSS  P     P  SP ++      +PT+ P    V 
Sbjct: 475  EASGKGAELYARRQSRMEKYVIESSSHTPELARCP--SPTMSLPSSWKYPTNAPGAFRVA 532

Query: 804  SSIKIAQP--------------------SYPPARPASTLNVAGPFKG------------- 830
            S      P                      PP +   +L V  P K              
Sbjct: 533  SRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAK 592

Query: 831  ----------PQAAVASQNYTPKPTVSTPTV------NAVQPGAVGP--SNELPGMSGRG 872
                      P+ A+      P+P+ S+P +      +++QP AV P    ++  +S   
Sbjct: 593  PSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSR 652

Query: 873  AQLFAKRQSRMEKYVVDSDTVQAHAARAQSPT-----------PS------LPASWK--Y 913
            A     +Q+    +   +  ++A   R   PT           PS       P  W+   
Sbjct: 653  AWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGR 712

Query: 914  SSNVRAPPPVAYNPIHSPSY---PLAALKSQPSAAQPSK-MGKKKGKKPLNALDVMKHQP 969
             S++ +PPP+   P  SPS+    ++ L+ +  A  PS+ +     +  +NA       P
Sbjct: 713  GSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASP 772

Query: 970  YQLNA-SLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVP 1028
                A +   F PP A    P            M+   P RP +AA P     ++   +P
Sbjct: 773  RSAGAENPRPFSPPRAPPPPPPPPPPPPR----MRSPQPARPGSAAVP----GAAFAPIP 824

Query: 1029 AYTSP--PSFFAEASSPVSASPVPVGIPTSPKQESAS 1063
                P  PS      SP+ A P P     SP     S
Sbjct: 825  RSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVS 861



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 80/235 (34%), Positives = 109/235 (46%), Gaps = 38/235 (16%)

Query: 861  PSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAP 920
            P+  L   SG+GA+L+A+RQSRMEKYV++S +     AR  SPT SLP+SWKY +N    
Sbjct: 469  PNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNA--- 525

Query: 921  PPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNAL---DVMKHQPYQLNASLF 977
             P A+                P+   P+ +    G  P N +   +  K  PYQL  SLF
Sbjct: 526  -PGAFR----------VASRSPARTPPASL--YHGYLPENGVLRPEPTKQPPYQLRPSLF 572

Query: 978  TFQP-PDAKDGLPQKSSVKVNSALAM-----KQALPPRPVNAASPTNVQASSVYSVPAYT 1031
               P  +     P+ +S    S+L +     K ALPP P        +   S  S   YT
Sbjct: 573  VLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPA-------LPRPSRSSPGLYT 625

Query: 1032 SPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFV--APRPKFSAKKSGVTIQ 1084
            SP     ++  P + SP P G   SP   S + S     APRP FS + +G+  Q
Sbjct: 626  SPGQ---DSLQPTAVSP-PYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQ 676



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 98/473 (20%), Positives = 162/473 (34%), Gaps = 85/473 (17%)

Query: 484 LPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEES 543
           L + +GKGA ++A+R+ RM++   +        TP   +  + T  L ++  Y      +
Sbjct: 473 LSEASGKGAELYARRQSRMEKYVIESSSH----TPELARCPSPTMSLPSSWKYPTNAPGA 528

Query: 544 VRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPF 603
            R            S      P  + + G          +P N   +P P    QP    
Sbjct: 529 FRV----------ASRSPARTPPASLYHG---------YLPENGVLRPEP--TKQPPYQL 567

Query: 604 SPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDS 663
            P+  + SPI +     P +A    P +     + P       P  P+P+  S P  Y S
Sbjct: 568 RPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSR-SSPGLYTS 626

Query: 664 SERIASRDERISVP------AKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNS 717
             + + +   +S P                + +   +P F+ +   +       SL  + 
Sbjct: 627 PGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSP 686

Query: 718 EGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVS 777
                 GA       + ++S G     +     +   +PPP+ P P           P+S
Sbjct: 687 PWT--PGASRPPSSLDGWVSPGP----WEPGRGSSMSSPPPLPPPP-----------PMS 729

Query: 778 PVWSP-GVAPTQPP--AFPTSNPSKGTVVSSI-KIAQPSYPPARPASTLNVAGPFKGPQA 833
           P WS   V+P +P   A P S   +  +  +I   A+      R A   N   PF  P+A
Sbjct: 730 PSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPR-PFSPPRA 788

Query: 834 AVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTV 893
                   P P    P + + QP   G S  +PG                          
Sbjct: 789 PPPP----PPPPPPPPRMRSPQPARPG-SAAVPGA------------------------- 818

Query: 894 QAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQ 946
            A A   +SP P+ P+S     +    PP  +    SP+    +L S+ S A+
Sbjct: 819 -AFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGAK 870


>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
          Length = 1970

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 111/473 (23%), Positives = 170/473 (35%), Gaps = 45/473 (9%)

Query: 615  DFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQ---PAFYDSSERIASRD 671
            + P   P      P   F     SP+ G +     P   PW+Q   PA+   S  + S  
Sbjct: 1485 EIPTNIPGLGAAGPTGMFFGSAPSPMGGIS-----PAMTPWNQGATPAYGAWSPSVGSG- 1538

Query: 672  ERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGP 731
                 P         A   S   P ++   P  SP P               G+ G  GP
Sbjct: 1539 ---MTPGAAGFSPSAASDASGFSPGYS---PAWSPTP---------------GSPGSPGP 1577

Query: 732  EEDYLSL--GAEACNFMQSSSAKQKTPP----PVAPKPAVKSSSSQPVTPVSPVWSPGVA 785
               Y+    GA + ++  +S A +   P    P +P  +  S S  P +P     SP  +
Sbjct: 1578 SSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYS 1637

Query: 786  PTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPA-STLNVAGPFKGPQAAVASQNYTPKP 844
            PT P   PTS PS      S     PSY P  P+ S  + +     P  +  S +Y+P  
Sbjct: 1638 PTSPSYSPTS-PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTS 1696

Query: 845  TVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPT 904
               +PT  +  P +   S   P  S           S        S T   ++  + + T
Sbjct: 1697 PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYT 1756

Query: 905  PSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDV 964
            P+ P S+  +S   +P    Y P  SP+Y   +    P++  PS         P +    
Sbjct: 1757 PTSP-SYSPTSPSYSPTSPNYTPT-SPNYSPTSPSYSPTS--PSYSPTSPSYSPSSPRYT 1812

Query: 965  MKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRP-VNAASPTNVQASS 1023
             +   Y  ++  ++   P      P+ +    + + +  +  P  P  +  SP     S 
Sbjct: 1813 PQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSP 1872

Query: 1024 VYSVPAYT-SPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFS 1075
             YS  + T SP +     +SP  +   PV  PTSPK    S +Y     PK+S
Sbjct: 1873 KYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTY-SPTSPKYS 1924



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 114/489 (23%), Positives = 170/489 (34%), Gaps = 66/489 (13%)

Query: 592  FPGSVNQPATPFSPTRNM----TSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAG--PAQ 645
            F GS   P    SP         +P     +P   S +TP    FS   +S  +G  P  
Sbjct: 1502 FFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPGY 1561

Query: 646  PPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVS 705
             P W  P P S  +   SS  I S    +S     T    E +      P    + P  S
Sbjct: 1562 SPAW-SPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTP----QSPSYS 1616

Query: 706  PNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAV 765
            P     S                + P     S    + N+  +S +   T P  +P    
Sbjct: 1617 PTSPSYS---------------PTSP-----SYSPTSPNYSPTSPSYSPTSPSYSPTSPS 1656

Query: 766  KSSSSQPVTPVSPVW---SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTL 822
             S +S   +P SP +   SP  +PT P   PTS PS      S     PSY P  P+ + 
Sbjct: 1657 YSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTS-PSYSPTSPSYSPTSPSYSPTSPSYSP 1715

Query: 823  NVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSR 882
                    P  +  S +Y+P     +PT  +  P +   S   P  +             
Sbjct: 1716 T------SPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSY------- 1762

Query: 883  MEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQP 942
                   S T  +++  + + TP+ P ++  +S   +P   +Y+P  SPSY  ++ +  P
Sbjct: 1763 -------SPTSPSYSPTSPNYTPTSP-NYSPTSPSYSPTSPSYSPT-SPSYSPSSPRYTP 1813

Query: 943  SA-----AQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVN 997
             +     + PS         P +         Y  ++  +T   P      P+ S     
Sbjct: 1814 QSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPK 1873

Query: 998  SALAMKQALPPRP-VNAASPTNVQASSVY--SVPAYTSPPSFFAEASSPVSASPVPVGIP 1054
             +       P  P  +  SPT    S VY  + P Y SP S     +SP  +   P   P
Sbjct: 1874 YSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKY-SPTSPTYSPTSPKYSPTSPTYSP 1932

Query: 1055 TSPKQESAS 1063
            TSPK  + S
Sbjct: 1933 TSPKGSTYS 1941



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 76/321 (23%), Positives = 115/321 (35%), Gaps = 48/321 (14%)

Query: 548  SSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPFSPTR 607
            S  S SY   S    + P    +S TS + +     P + +  P   S +  +  +SPT 
Sbjct: 1679 SPTSPSYSPTSPS--YSPTSPSYSPTSPSYS-----PTSPSYSPTSPSYSPTSPSYSPTS 1731

Query: 608  NMTSPIADF--PAPPPYSAVTP--PPDAFSRGVSSPIAGPAQP---PPWPQPAPWSQPAF 660
               SP +    P  P YS  +P   P + S   +SP   P  P   P  P  +P S P++
Sbjct: 1732 PSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTS-PSY 1790

Query: 661  YDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGK 720
              +S   +      S  + R     ++   + + P ++   P  SP     +    S   
Sbjct: 1791 SPTSPSYSPTSPSYSPSSPR--YTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSP 1848

Query: 721  RGTGAGGDSGPEEDYLS--LGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSP 778
                    S PE    S      +  +  +S     T P  +P     S +S   +P SP
Sbjct: 1849 --------SSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSP 1900

Query: 779  VW---SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAV 835
            V+   SP  +PT P   PTS     T         P+Y P  P          KG   + 
Sbjct: 1901 VYTPTSPKYSPTSPTYSPTSPKYSPT--------SPTYSPTSP----------KGSTYSP 1942

Query: 836  ASQNYTPKPTVSTPTVNAVQP 856
             S  Y+P     + T  A+ P
Sbjct: 1943 TSPGYSPTSPTYSLTSPAISP 1963


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 120/517 (23%), Positives = 184/517 (35%), Gaps = 70/517 (13%)

Query: 584  PMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFP--APPPYSAVTPPPDA--FSRGVSSP 639
            P    ++  P     PA+P     +++ P+ + P   PP  S ++PPP++  FS    SP
Sbjct: 460  PPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESP 519

Query: 640  IAGPAQPPPWP------QPAPWSQPAF--YDSSERIASRDERISVPAKRTGILQEAKRRS 691
            ++ P + PP P       P P + P    ++ S      +E  + P      L      S
Sbjct: 520  LSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEES 579

Query: 692  TTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSA 751
               P    +E  +SP PE   L    E      +     PEE  LS   EA         
Sbjct: 580  PMSP--PPEESPMSPPPEASRLFPPFE-----ESPLSPPPEESPLSPPPEASRLSPPPED 632

Query: 752  KQKTPP----PVAPKPAVKSSSSQP-VTPVSPVWSPGVAPTQPP--AFPTSNPSKGTVVS 804
               +PP    P++P P V   S  P V+ +SP   P  +P  PP    PTS P + + +S
Sbjct: 633  SPMSPPPEESPMSPPPEVSRLSPLPVVSRLSP--PPEESPLSPPPEESPTSPPPEASRLS 690

Query: 805  SIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNE 864
                  P+ PP           P   P +     +    P   +P +   +   + P +E
Sbjct: 691  PPPEDSPTSPP-----------PEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSE 739

Query: 865  LPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPVA 924
             P +S R  +       R E+  +     + H     SP P  P              V 
Sbjct: 740  GPHLSPRPEE--PHLSPRPEEPHLSPQAEEPHL----SPQPEEPCLC----------AVP 783

Query: 925  YNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDA 984
              P  SP      L  QP     S   ++    P+     +  QP + + S  + +P   
Sbjct: 784  EEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEP--C 841

Query: 985  KDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSP--PSFFAEASS 1042
                P++S +   S    K  L PRP         Q  +   +P +  P  PS       
Sbjct: 842  LSPRPEESHL---SPELEKPPLSPRPEKPPEEPG-QCPAPEELPLFPPPGEPSLSPLLGE 897

Query: 1043 PVSA-------SPVPVGIPTSPKQESASSSYFVAPRP 1072
            P  +       SP+P  +P SP  E + S   + P P
Sbjct: 898  PALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDP 934



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 91/402 (22%), Positives = 135/402 (33%), Gaps = 67/402 (16%)

Query: 601  TPFSPTRNMTSPIADFP-APPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPA 659
            +P      ++ P  + P +PPP  + T PP   SR    P   P  PPP   PA  S P 
Sbjct: 654  SPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPA--SPP- 710

Query: 660  FYDSSERIASRDERISVPAKRTGIL------QEAKRRSTTKPMFTFKEPKVSPNPELLSL 713
                       D  +S+P + + +L      Q   R          +EP +SP PE   L
Sbjct: 711  ---------PEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHL 761

Query: 714  LQNSEGKRGTGAGGD----SGPEEDYLSLGAEACNFMQSSSAKQKTP----PPVAPKPAV 765
               +E    +    +    + PEE +LS  AE  +          +P    P ++P P  
Sbjct: 762  SPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEE 821

Query: 766  KSSSSQP---------------------------------VTPVSPVWSPG--VAPTQPP 790
               S QP                                   P  P   PG   AP + P
Sbjct: 822  PCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELP 881

Query: 791  AF-PTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTP 849
             F P   PS   ++    +++P  PP  P        P   P  +       P P   +P
Sbjct: 882  LFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSP 941

Query: 850  TVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPA 909
             + A  P A+ P  EL      GA+  +  +S +   ++++       A    P P  P 
Sbjct: 942  IITAAAPPALSPLGELE--YPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPM 999

Query: 910  SWKYS--SNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSK 949
                S  S V    P+   P+     PL      P  + PS+
Sbjct: 1000 ILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQ 1041



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 121/503 (24%), Positives = 178/503 (35%), Gaps = 93/503 (18%)

Query: 601  TPFSPTRN---MTSPIADFP-APPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWS 656
            TP SP      ++ P  + P +PPP    T PP   SR    P   P  PP  P+ +P S
Sbjct: 534  TPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPP--PEESPMS 591

Query: 657  QPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQN 716
             P                           EA R         F+E  +SP PE   L   
Sbjct: 592  PP--------------------------PEASRLFP-----PFEESPLSPPPEESPLSPP 620

Query: 717  SEGKRGTGAGGDS----GPEEDYLSLGAEACNFMQSSSAKQKTPP----PVAPKPAVKSS 768
             E  R +    DS     PEE  +S   E           + +PP    P++P P    +
Sbjct: 621  PEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPT 680

Query: 769  SSQP-VTPVSPVWSPGVAPTQPPA--FPTSNPSKGTVVSSIKIAQPSYP-PARPASTLNV 824
            S  P  + +SP   P  +PT PP    P S P + +++S      P  P P  P      
Sbjct: 681  SPPPEASRLSP--PPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRS 738

Query: 825  AGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQS--- 881
             GP   P+      + +P+P     +  A +P  + P  E P +     +     Q+   
Sbjct: 739  EGPHLSPRP--EEPHLSPRPEEPHLSPQAEEP-HLSPQPEEPCLCAVPEEPHLSPQAEGP 795

Query: 882  ----RMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSP----SY 933
                + E+  +   T + H     SP P  P            P  +  P  SP    S+
Sbjct: 796  HLSPQPEELHLSPQTEEPHL----SPVPEEPCLSPQPEESHLSPQ-SEEPCLSPRPEESH 850

Query: 934  PLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSS 993
                L+  P + +P K  ++ G+ P          P +L      F PP    G P  S 
Sbjct: 851  LSPELEKPPLSPRPEKPPEEPGQCP---------APEELP----LFPPP----GEPSLSP 893

Query: 994  VKVNSALAMKQALPPRPVN---AASPTNVQASSVYSVPAYTSPP--SFFAEASSPVSASP 1048
            +    AL+     P  P+      SP+   + S   +P    PP  S    A++P + SP
Sbjct: 894  LLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSP 953

Query: 1049 V-PVGIPTSPKQESASSSYFVAP 1070
            +  +  P   K +S   S   AP
Sbjct: 954  LGELEYPFGAKGDSDPESPLAAP 976



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 114/492 (23%), Positives = 171/492 (34%), Gaps = 100/492 (20%)

Query: 511  EDKVGGTPSREQDAAQTDGLRTTTSYQRKEEESVRTQSSVSK----SYIEVSHGL-GHVP 565
            E K+ GTPS ++DAA    L  T   +R ++ S R  SS  K      +  S  L   + 
Sbjct: 4499 EQKLQGTPSNKEDAAARKPL--TPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLK 4556

Query: 566  QQNGFSGTSE---TANIQRMVPMNRTA-----KPFPGSVNQPATPFSPT--------RNM 609
            Q+      +E   TAN     P              G+    A P  P          N+
Sbjct: 4557 QELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNL 4616

Query: 610  TSPIADFPAPPPYSAVTPPPDAFSRGVS--SPIAGPAQPPPWPQPAPWSQPAFYDSSERI 667
            ++P    P PP     TPPP    + V+  +P     + P     A  S+ A  D+SE +
Sbjct: 4617 SNP----PTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTSE-V 4671

Query: 668  ASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGG 727
             S D   ++P       ++ +  S         E   SP+  + +               
Sbjct: 4672 KSLDLLAALPTPPHNQTEDVRMESD--------EDSDSPDSIVPA--------------- 4708

Query: 728  DSGPEEDYLSLGAEACNFMQSSSAK-QKTPPPVAPKPAVKSSSSQPVTP-VSPVWSPGVA 785
             S PE     LG EA  F    S + ++    ++P   +   +S PV P   P  + G+ 
Sbjct: 4709 -SSPES---ILGEEAPRFPHLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKPYGALGLE 4764

Query: 786  PTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPT 845
                    T    KG+ VS +         A  A  LN      G   AVA       P 
Sbjct: 4765 VPGKLPVTTWEKGKGSEVSVMLTVS-----AAAAKNLN------GVMVAVAELLSMKIPN 4813

Query: 846  V------STPTVNAVQPG---AVGPSNELPGMSGR----GAQLFAKRQSRMEKYVVDSDT 892
                    +P     +P    A GP  +  G+ G+    G     +  + +  Y + S  
Sbjct: 4814 SYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQL 4873

Query: 893  VQAHAARAQSPTPSLPASWKYSSNVR--------APPP---------VAYNPIHSPSYPL 935
                  + +SP P  P    Y+ NV         APPP         +A +P   P+ PL
Sbjct: 4874 DILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPL 4933

Query: 936  AALKSQPSAAQP 947
              L ++P A  P
Sbjct: 4934 VELPTEPLAEPP 4945



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 105/505 (20%), Positives = 165/505 (32%), Gaps = 73/505 (14%)

Query: 573  TSETANIQRMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFP--APPPYSAVTPPPD 630
            TS      R+ P    +   P     P +P      +  P  + P   PP  S ++PPP+
Sbjct: 563  TSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPE 622

Query: 631  AFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRR 690
            A SR    P   P  PP  P+ +P S P        +     R+S P + + +    +  
Sbjct: 623  A-SRLSPPPEDSPMSPP--PEESPMSPPPEVSRLSPLPV-VSRLSPPPEESPLSPPPEES 678

Query: 691  STTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSS 750
             T+ P    +  ++SP PE      +        +     PE+  +SL  E    +    
Sbjct: 679  PTSPPP---EASRLSPPPE-----DSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPE 730

Query: 751  AKQKTP----PPVAPKPAVKSSSSQPVTP-VSP-VWSPGVAPTQPPAFPTSNPSKGTVVS 804
              Q  P    P ++P+P     S +P  P +SP    P ++P                  
Sbjct: 731  EPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSP------------------ 772

Query: 805  SIKIAQPSYP-----PARPASTLNVAGPFKGPQAA---VASQNYTP--KPTVSTPTVN-A 853
                 QP  P     P  P  +    GP   PQ     ++ Q   P   P    P ++  
Sbjct: 773  -----QPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQ 827

Query: 854  VQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPS----LPA 909
             +   + P +E P +S R  +  +     +EK  +     +      Q P P      P 
Sbjct: 828  PEESHLSPQSEEPCLSPRPEE--SHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPP 885

Query: 910  SWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQP 969
              + S +     P    P   P  PL        + +PS   +     PL         P
Sbjct: 886  PGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPL---------P 936

Query: 970  YQLNASLFTFQPP--DAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSV 1027
              L+  +    PP       L      K +S      A P      + P     +    V
Sbjct: 937  PPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPV 996

Query: 1028 PAYTSPPSFFAEA--SSPVSASPVP 1050
            P    PPS  +    +SP+   P+P
Sbjct: 997  PPMILPPSPGSPVGPASPILMEPLP 1021



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 97/432 (22%), Positives = 149/432 (34%), Gaps = 91/432 (21%)

Query: 587  RTAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPP---------------DA 631
            R  +P P     P+ P  P         D  A PP +    PP               D 
Sbjct: 2348 RPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDP 2407

Query: 632  FSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDS--SERIASRDERISVPAKRTGILQEAKR 689
            FSR  +SP +  +   P   P P S  AF  S  + R  S D     P++        + 
Sbjct: 2408 FSRVPASPQSQSSSQSPL-TPRPLSAEAFCPSPVTPRFQSPDPYSRPPSR-------PQS 2459

Query: 690  RSTTKPMFTFKEPKVSPNPELL----SLLQNSEGKRGTGAGGDSGPEEDYLSL--GAEAC 743
            R    P+   K P+  P PE+     SL   S G  G  A   +GP  +  +     +  
Sbjct: 2460 RDPFAPL--HKPPRPQP-PEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPP 2516

Query: 744  NFMQS---------SSAKQKTPPPVAPKPAVKSSSSQPVTP----VSPVWSPGVAPTQP- 789
            NF++S          S  + T P    +P++K    QP  P    ++  + PG    +P 
Sbjct: 2517 NFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQ 2576

Query: 790  ------------PAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVAS 837
                        P+     PS G+   S  ++     P RP S L    P         S
Sbjct: 2577 STNYTVATGNFHPSGSPLGPSSGSTGESYGLS-----PLRPPSVLPPPAP--DGSLPYLS 2629

Query: 838  QNYTPKPTVSTPTVNAVQPG---------AVGPSNELPGMSGRG-AQLFAKRQSRMEKYV 887
               + +  +++P      PG         A  P  + PGMSG    +L  +RQ +  + +
Sbjct: 2630 HGASQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLREL 2689

Query: 888  VDSDTVQAHAARAQSPTPSL-------PASWKYSSNVRAPPPVAYNPIHSPSYPLAALKS 940
            +    +Q +  R +  T +        P SW        P   A+  +     P A  + 
Sbjct: 2690 LIRQQIQRNTLRQEKETAAAAAGAVGPPGSWG-----AEPSSPAFEQLSRGQTPFAGTQD 2744

Query: 941  QPS--AAQPSKM 950
            + S     PSK+
Sbjct: 2745 KSSLVGLPPSKL 2756



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 95/457 (20%), Positives = 148/457 (32%), Gaps = 118/457 (25%)

Query: 617  PAPPPYSAVTPPPD-AFSRGVSSP-IAGPAQPP--PWPQPAPWSQPAFYDSSERIASRDE 672
            PAP       PP + + S  +  P ++ P +PP  P P+  P S       S ++   D 
Sbjct: 875  PAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDP 934

Query: 673  RISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPE 732
               +P   + I+  A              P +SP  EL         +   GA GDS PE
Sbjct: 935  ---LPPPLSPIITAAA------------PPALSPLGEL---------EYPFGAKGDSDPE 970

Query: 733  EDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAF 792
                           S  A      P++P P    +  +PV P+    SPG +P  P   
Sbjct: 971  ---------------SPLAAPILETPISPPPEANCTDPEPVPPMILPPSPG-SPVGP--- 1011

Query: 793  PTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVN 852
                       +S  + +P  P   P             Q ++  QN +P    S P + 
Sbjct: 1012 -----------ASPILMEPLPPQCSPLL-----------QHSLVPQN-SPPSQCSPPALP 1048

Query: 853  AVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPT-PSLPASW 911
               P  + P  ++ G+S                     D  + H    +  + P  PA  
Sbjct: 1049 LSVPSPLSPIGKVVGVS---------------------DEAELHEMETEKVSEPECPAL- 1086

Query: 912  KYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQP-- 969
                      P A +P+ SP   L+     P+ A     G  +   PL+ +D    QP  
Sbjct: 1087 ---------EPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEP 1137

Query: 970  --------YQLNASLFTFQPPD-----AKDGLPQKSSVKVNSALAMKQALPPRPVNAASP 1016
                     +L  S     P +       +  P+        +   +Q  P  PV    P
Sbjct: 1138 GQTPGSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPP 1197

Query: 1017 TNVQASSVYSVPAYT-SPPSFFAEASSPVSASPVPVG 1052
            T +++  V  +   +    S     S P+  SP P G
Sbjct: 1198 TLIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEG 1234



 Score = 35.0 bits (79), Expect = 0.39
 Identities = 113/550 (20%), Positives = 168/550 (30%), Gaps = 118/550 (21%)

Query: 591  PFPGSVNQPATPFSPTRNMTSPIA----------------------DFPA------PPPY 622
            P PG++  P    +PT  + SP                        D P       PP  
Sbjct: 2108 PQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQV 2167

Query: 623  SAVTPPPDAFSRGVSSPI-----AGPAQPPPWPQP--APWSQPAFYDSSERIASRDERIS 675
             A  P  D F    + P+       P   PP+P P  AP   P    SS   A +     
Sbjct: 2168 PAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFH 2227

Query: 676  VPAKRTGILQEAKRRSTTKPMF-----------------TFKEPKVSPNP--ELLSLLQN 716
                 T   Q +      KP                      EP +SP P  E    L+ 
Sbjct: 2228 TTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGESRKALEV 2287

Query: 717  SEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPV 776
             + + G  +     P   ++   +   +       + KTP         ++S  +P +P 
Sbjct: 2288 KKEELGASSPSYGPPNLGFVDSPSSGTHL---GGLELKTPDVFKAPLTPRASQVEPQSP- 2343

Query: 777  SPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPA-RPASTLNVAGPFKGPQAAV 835
                  G+ P +PP      PS            PS+P   RP S      P+  P    
Sbjct: 2344 ----GLGLRPQEPPPAQALAPS-----------PPSHPDIFRPGS---YTDPYAQPP--- 2382

Query: 836  ASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQA 895
                 TP+P    P      P    PS+    +     Q  +  QS +        T + 
Sbjct: 2383 ----LTPRPQPPPPESCCALPPRSLPSDPFSRVPA-SPQSQSSSQSPL--------TPRP 2429

Query: 896  HAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKG 955
             +A A  P+P  P         ++P P +  P    S    A   +P   QP ++  K G
Sbjct: 2430 LSAEAFCPSPVTP-------RFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAG 2482

Query: 956  KKPLNALD-------VMKHQPYQLNASLFTFQPPD--------AKDGLPQKSSVKVNSAL 1000
                 +L        +      +L+A + + QPP+        A  G P         A+
Sbjct: 2483 SLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAV 2542

Query: 1001 AMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQE 1060
                  PP P     P +   S     P    P S      +  + +  P G P  P   
Sbjct: 2543 GEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQS---TNYTVATGNFHPSGSPLGPSSG 2599

Query: 1061 SASSSYFVAP 1070
            S   SY ++P
Sbjct: 2600 STGESYGLSP 2609



 Score = 32.0 bits (71), Expect = 3.3
 Identities = 36/139 (25%), Positives = 48/139 (34%), Gaps = 21/139 (15%)

Query: 521  EQDAAQTDGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQ 580
            ++   Q+  +R T  YQ    ++   Q             LG  PQ  GF G  +T  +Q
Sbjct: 4228 QRQLQQSQAVRQTPPYQEPGTQTSPLQGL-----------LGCQPQLGGFPGP-QTGPLQ 4275

Query: 581  RMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIAD--FPAPPPYSAVTPPPDAFSRGVSS 638
             +    R   P       P  P  P    T P+     P PPP S   P   +     SS
Sbjct: 4276 ELGAGPRPQGP-------PRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSS 4328

Query: 639  PIAGPAQPPPWPQPAPWSQ 657
             +   AQ PP     P  Q
Sbjct: 4329 QLPTEAQLPPTHPGTPKPQ 4347



 Score = 30.8 bits (68), Expect = 7.3
 Identities = 18/64 (28%), Positives = 30/64 (46%), Gaps = 12/64 (18%)

Query: 607  RNMTSPIADFPAPPPY----SAVTPPPDAFSRGVSSPIAGPAQPPPWP--------QPAP 654
            R +++P  + P+PPP     S  +PP +      + P+A P  P P P        +P P
Sbjct: 4904 RQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKP 4963

Query: 655  WSQP 658
             ++P
Sbjct: 4964 RARP 4967



 Score = 30.4 bits (67), Expect = 9.6
 Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 10/66 (15%)

Query: 598  QPATPFSPTRNMTS-PIADFPAPPPYSAVTPPPDAFSRGVSSP-----IAGPAQP---PP 648
            +P T  S T N+++  +    APPP    +PPP   +   +SP     +  P +P   PP
Sbjct: 4887 EPPTQHSYTYNVSNLDVRQLSAPPPEEP-SPPPSPLAPSPASPPTEPLVELPTEPLAEPP 4945

Query: 649  WPQPAP 654
             P P P
Sbjct: 4946 VPSPLP 4951


>gi|13994151 PDZ and LIM domain 1 [Homo sapiens]
          Length = 329

 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 47/169 (27%), Positives = 80/169 (47%), Gaps = 4/169 (2%)

Query: 9   ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
           I + G  PWGFRL GGK+ +QPL ++++   SKA+ + LC GD + +I+G   +++T+ E
Sbjct: 6   IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65

Query: 69  VIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQC 128
               ++  TD+L + + R    +   L++E E K   +  +        L I  A     
Sbjct: 66  AQNRIKGCTDNLTLTVARSEHKVWSPLVTE-EGKRHPYKMNLASEPQEVLHIGSAHNRSA 124

Query: 129 TEFFLAPV-KTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRG 176
             F  +P   T   +  NQ + P  AG    E   ++  A +   +  G
Sbjct: 125 MPFTASPASSTTARVITNQYNNP--AGLYSSENISNFNNALESKTAASG 171


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 150/602 (24%), Positives = 204/602 (33%), Gaps = 107/602 (17%)

Query: 518  PSREQDAAQTDGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGT-SET 576
            P+ +  A+ T   + T +Y            S S   + VS      P + G +G  +  
Sbjct: 771  PTEDSGASATASSKGTLTY---------LADSPSPLGVSVSPQTKRPPTKKGSAGPDTPI 821

Query: 577  ANIQRMV-PMNRTAKP-----FPGSVNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPD 630
             N+   V P+  +  P     F GS + PAT  SPT     P +   AP P SAVTP   
Sbjct: 822  GNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPT-----PPSPKGAPTP-SAVTP--- 872

Query: 631  AFSRGVSSPIAGPAQPP-------PWPQ-----PAPWSQPAFYDSSERIASRDERISVPA 678
               +GV+ P   P + P       P+P+     PAP   PA   +S   +S  +  + PA
Sbjct: 873  LSPKGVTLP---PKETPTPSVVNLPFPKEGPATPAPKQAPALSMTS---SSPKKARATPA 926

Query: 679  KRTGILQEAKRRSTTKPMFTFKEPK---VSPNPELLSLLQNSEGKRGTGAGGDSGPEEDY 735
             +      + + + T P  T   PK    +P+P+             T      GP    
Sbjct: 927  PKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWA-----PTPPAATPPSPKGGP---- 977

Query: 736  LSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTS 795
                        + S K    PP A  P+ K   + P +P      P V P  P   P +
Sbjct: 978  -----------ATPSPKGAPTPPAATPPSPKGGPATP-SPKGAPTPPAVTPPSPKGSPAA 1025

Query: 796  NP-SKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAV 854
             P  KG   S+   A P  P   PA+T    G    P A + S    PK   +TP++   
Sbjct: 1026 TPFPKG--ASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPS----PKGGPATPSLK-- 1077

Query: 855  QPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYS 914
              GA  P    P     G    + + + M             A       P+ PA+   S
Sbjct: 1078 --GAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPS 1135

Query: 915  --SNVRAPPP--VAYNPIHSPSYPLAAL--------KSQPSAAQPSKMGKKKGKKPLNAL 962
                +  PPP      P  +P  P   L         + P+A  PS  G      P  A 
Sbjct: 1136 PKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAP 1195

Query: 963  DVMKHQPYQLNASLFT-----------FQPPDAKDGLPQKSSVKVNSALAMKQALPPRPV 1011
                  P      L T             PP  K GL   S      A     A PP P 
Sbjct: 1196 TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSP---KGAPTTPAATPPSP- 1251

Query: 1012 NAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASPVP-VGIPTSPKQESASSSYFVAP 1070
                P         + PA T P      A+ P   +P P V  P SPK   A+S    AP
Sbjct: 1252 -KGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAP 1310

Query: 1071 RP 1072
             P
Sbjct: 1311 TP 1312



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 144/569 (25%), Positives = 195/569 (34%), Gaps = 111/569 (19%)

Query: 591  PFPGSVNQP-------ATPFSPTRNMTSPIADFPAPPPYSAVTP----PPDAFSRGVSSP 639
            P P +V  P       ATPF P    T P A  P+P    A TP     P   +  + SP
Sbjct: 1009 PTPPAVTPPSPKGSPAATPF-PKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSP 1067

Query: 640  IAGPA--------QPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRS 691
              GPA         PP    P+P   PA    S + A      + P+ + G+     + +
Sbjct: 1068 KGGPATPSLKGAPTPPAATPPSPKGGPA--TPSPKGAPMPPAATPPSPKGGLATPPHKGA 1125

Query: 692  TTKPMFTFKEPK---VSPNPE---LLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNF 745
             T P  T   PK    +P P+             K G       G      +        
Sbjct: 1126 PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG 1185

Query: 746  MQSSSAKQKTPPPVAPKPAVKSSSSQP----------VTPVSP-----VWSPGVAPTQPP 790
            + + S K     P A  P+ K   + P           TP SP       SP  APT P 
Sbjct: 1186 LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPA 1245

Query: 791  AFPTSNPSKGTVVSSIKIAQPSYPPARPASTLN--VAGPFKG-PQAAVASQNYTPK--PT 845
            A P S P  G      K A P+ P A P S        P KG P  AV +   +PK  P 
Sbjct: 1246 ATPPS-PKGGPATPPPKGA-PTPPAATPPSLKGGLATPPHKGAPNPAVVTPP-SPKGGPA 1302

Query: 846  VSTPTVNAVQPGAVGPSNE-LPGM-SGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSP 903
             S P      P A  PS +  PG    +GA                  T  A    +   
Sbjct: 1303 TSPPKGAPTPPAATPPSPKGSPGTPPPKGA-----------------PTPPAVTPPSPKG 1345

Query: 904  TPSLPASWKYS-------SNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGK 956
            TP+LPA+   S       S+   P P A  P H     +     +   A PS  G     
Sbjct: 1346 TPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSP 1405

Query: 957  KPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAA-- 1014
                   V+   P +  A+      P  ++G    S   +        +L   P  +A  
Sbjct: 1406 A------VIPLSPKKAPAT------PVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPK 1453

Query: 1015 -SPTNVQASSVYSVPAYTSP-------PSFFAEASSP--VSASPVPVG-------IPTSP 1057
              P    +    ++PA T P       P   A +SSP    A+P P+G       IP+SP
Sbjct: 1454 GGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSP 1513

Query: 1058 KQESASSSYF---VAPRPKFSAKKSGVTI 1083
            K+  A+ S     +AP     +KK+  T+
Sbjct: 1514 KEVPATPSSRRDPIAPTATLLSKKTPATL 1542



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 137/521 (26%), Positives = 175/521 (33%), Gaps = 74/521 (14%)

Query: 566  QQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSAV 625
            Q    S TS +    R  P     K  P S +    P  P     SP      P P  A 
Sbjct: 907  QAPALSMTSSSPKKARATP---APKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAP 963

Query: 626  TPP---PDAFSRGVSSPI-AGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPA-KR 680
            TPP   P +   G ++P   G   PP    P+P   PA    S + A     ++ P+ K 
Sbjct: 964  TPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPA--TPSPKGAPTPPAVTPPSPKG 1021

Query: 681  TGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGA 740
            +       + ++T P  T   PK SP    L      +G   T A     P+      G 
Sbjct: 1022 SPAATPFPKGASTPPAATPPSPKGSPAATPL-----PKGAPTTPAATLPSPK------GG 1070

Query: 741  EACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKG 800
             A     + S K    PP A  P+ K     P TP     SP  AP  P A P S   KG
Sbjct: 1071 PA-----TPSLKGAPTPPAATPPSPKGG---PATP-----SPKGAPMPPAATPPS--PKG 1115

Query: 801  TVVSSIKIAQPSYPPARPASTLN--VAGPFKGPQAAVASQNYTPKPTVSTPTVNA--VQP 856
             + +      P+ P A P S        P KG     A+   +PK  ++TP        P
Sbjct: 1116 GLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTP 1175

Query: 857  GAVGPSNE--LPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSL--PASWK 912
             A  PS +  L   S +GA                       AA   SP   L  P+   
Sbjct: 1176 AATPPSPKGGLATPSPKGAP-------------------TTPAATPPSPKGGLATPSPKG 1216

Query: 913  YSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQL 972
              +   A PP     + +PS P  A  + P+A  PS  G      P  A       P  L
Sbjct: 1217 APTTPAATPPSPKGGLATPS-PKGA-PTTPAATPPSPKGGPATPPPKGAPTPPAATPPSL 1274

Query: 973  NASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTS 1032
               L T  PP    G P  + V   S        PP+   A +P      S    P  T 
Sbjct: 1275 KGGLAT--PP--HKGAPNPAVVTPPSPKGGPATSPPK--GAPTPPAATPPSPKGSPG-TP 1327

Query: 1033 PPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPK 1073
            PP      + P    P P G PT P    +S      P  K
Sbjct: 1328 PPK--GAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSK 1366



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 124/527 (23%), Positives = 175/527 (33%), Gaps = 92/527 (17%)

Query: 602  PFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPW---PQPAPWS-- 656
            P   T  + +   + P P   +AV P   A S   +    GP  PPP    PQ  P S  
Sbjct: 2    PGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAA 61

Query: 657  -QPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSP--NPELLSL 713
             Q + + S   IAS    +  P   +G    A    T     TF    + P  +P  L+L
Sbjct: 62   NQASPFPSPSTIASTPLEVPFPQSSSG---TALPLGTAPEAPTFLPNLIGPPISPAALAL 118

Query: 714  LQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSS---- 769
                      G    S P    L+L A A + +Q SSA         P  AV  S     
Sbjct: 119  ASPMIAPTLKGTPSSSAP----LALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVIT 174

Query: 770  -SQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVS-----------SIKIAQPSYPPAR 817
             S P+ P  P  +    P++    P   PS   +VS           SI+    S P   
Sbjct: 175  LSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTT 234

Query: 818  PASTLNVAGP---------------------FKGPQAAVASQNYTPKPTVSTPTVNAVQP 856
            P +TL +A P                      KGP +  A+ + +   T S P V + Q 
Sbjct: 235  PTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLS---TQSLPVVTSSQK 291

Query: 857  GAVGPSNELPGMSGRGAQLFAKRQS-------------------RMEKYVVDSDTVQAHA 897
             A GP+         G+ L    QS                    ++   VD  +  A  
Sbjct: 292  TA-GPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASY 350

Query: 898  ARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKK 957
               +S  P LP     S N   P  VA  P+ +PS              PS         
Sbjct: 351  PSQRSVIPPLP-----SRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPS--------- 396

Query: 958  PLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPT 1017
               +L+V          SL     P+A    P  + + V+S       +      AA+PT
Sbjct: 397  --GSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPT 454

Query: 1018 NVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASS 1064
                 +    P  +S P    E +SP +    PV  P  P  + A++
Sbjct: 455  TTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVA-PKEPSTQVATT 500



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 125/552 (22%), Positives = 178/552 (32%), Gaps = 118/552 (21%)

Query: 582  MVPMNRTAKPFPGSVNQP--ATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSP 639
            M P      P  G    P    P +P     SP      PPP  A T P    +    SP
Sbjct: 1104 MPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTP----AATPPSP 1159

Query: 640  IAGPAQPPPWPQPA------PWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTT 693
              G A PPP   P       P  +      S + A      + P+ + G+   + + + T
Sbjct: 1160 KGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPT 1219

Query: 694  KPMFTFKEPK---VSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSS 750
             P  T   PK    +P+P+         G   T A     P+      G  A     +  
Sbjct: 1220 TPAATPPSPKGGLATPSPK---------GAPTTPAATPPSPK------GGPA-----TPP 1259

Query: 751  AKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVA-PTQPPAFPTSNPSKGTVVSSIKIA 809
             K    PP A  P++K   + P    +P  +P V  P  P   P ++P KG         
Sbjct: 1260 PKGAPTPPAATPPSLKGGLATPPHKGAP--NPAVVTPPSPKGGPATSPPKGA-------- 1309

Query: 810  QPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMS 869
             P+ P A P S     G    P+ A      TP     TPT+ A  P + G         
Sbjct: 1310 -PTPPAATPPSPKGSPGT-PPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTT----- 1362

Query: 870  GRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPT-----PSLPASWKYSSNVRAPPPVA 924
                       S  E     + T       A +P      P++P+      +  +P  + 
Sbjct: 1363 ----------PSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSP---KGDPTSPAVIP 1409

Query: 925  YNPIHSPSYPL----AALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNA----SL 976
             +P  +P+ P+    AA  S+     P+       K P  A    K  P   ++    +L
Sbjct: 1410 LSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAP--ATSAPKGGPATPSSKGDPTL 1467

Query: 977  FTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTS---- 1032
                PP  K+  P        S+   K    P P+ A +   V  SS   VPA  S    
Sbjct: 1468 PAVTPPSPKE--PPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRD 1525

Query: 1033 ------------------------PPSFFAEASSPVSASPVPVGIPTSPKQESAS----- 1063
                                    PP+    +     A P P   P +P  + AS     
Sbjct: 1526 PIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAV 1585

Query: 1064 --SSYFVAPRPK 1073
              S+Y  AP PK
Sbjct: 1586 TPSTYKGAPSPK 1597



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 114/504 (22%), Positives = 162/504 (32%), Gaps = 81/504 (16%)

Query: 584  PMNRTAKPFP-GSVNQPA-TPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIA 641
            P    A P P G+   PA TP SP   + +P       P   A TPP         SP  
Sbjct: 1205 PKGGLATPSPKGAPTTPAATPPSPKGGLATPSPK--GAPTTPAATPP---------SPKG 1253

Query: 642  GPAQPPPWPQPAPWSQPAFYDSS---------ERIASRDERISVPAKRTGILQEAKRRST 692
            GPA PPP   P P   PA    S          + A     ++ P+ + G      + + 
Sbjct: 1254 GPATPPPKGAPTP---PAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAP 1310

Query: 693  TKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAK 752
            T P  T   PK SP               GT     +           +    + +++  
Sbjct: 1311 TPPAATPPSPKGSP---------------GTPPPKGAPTPPAVTPPSPKGTPTLPATTPS 1355

Query: 753  QKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIA-QP 811
             K  P     P+ K   + P    S    P + P  P   P     KG   S   I   P
Sbjct: 1356 SKGGPTT---PSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSP 1412

Query: 812  SYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNE----LPG 867
               PA P +    A P KG     A    TP      P  +A + G   PS++    LP 
Sbjct: 1413 KKAPATPVTREGAATPSKGDLTPPA---VTPVSLKKAPATSAPKGGPATPSSKGDPTLPA 1469

Query: 868  MSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYS-SNVRAPPPVAYN 926
            ++        K     ++    S   +A A  A    P+LPA    S   V A P    +
Sbjct: 1470 VTPPSP----KEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRD 1525

Query: 927  PIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKD 986
            PI     P A L S+ +   P+ +  K+   P                   T   P    
Sbjct: 1526 PIA----PTATLLSKKT---PATLAPKEALIP----------------PAMTVPSPKKTP 1562

Query: 987  GLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSA 1046
             +P         +   K+A  P  V  ++     +     +P   + PS     + P   
Sbjct: 1563 AIPTPKEAPATPS--SKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVT 1620

Query: 1047 SPVPVGIPTSPKQESASSSYFVAP 1070
             P P   P +P  +   +S  V P
Sbjct: 1621 PPSPEKGPATPAPKGTPTSPPVTP 1644



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 122/520 (23%), Positives = 177/520 (34%), Gaps = 100/520 (19%)

Query: 593  PGSVNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQP 652
            P S   P TP S  +   +P A  P+     A+TPP       + SP   P  P   P  
Sbjct: 1354 PSSKGGPTTPSS--KEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPL- 1410

Query: 653  APWSQPAFYDSSERIASRDERISVP---------------AKRTGILQEAKRRSTTKPMF 697
            +P   PA   + E  A+  +    P               A + G    + +   T P  
Sbjct: 1411 SPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAV 1470

Query: 698  TFKEPKVSPNPELLSLLQNSEGKRGTGAGGD---------SGPEEDYLSLGAEACNFMQS 748
            T   PK  P P+ ++   + +    T A            S P+E   +  +       +
Sbjct: 1471 TPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPT 1530

Query: 749  SSA-KQKTPPPVAPK----------------PAVKSSSSQPVTPVSPVWS--PGVAPTQP 789
            ++   +KTP  +APK                PA+ +    P TP S   S  P V P+  
Sbjct: 1531 ATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTY 1590

Query: 790  PAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTP 849
               P+  P +  +  ++    P   P  PA T     P KGP         TP P   TP
Sbjct: 1591 KGAPS--PKELLIPPAVTSPSPKEAPTPPAVT--PPSPEKGPA--------TPAPK-GTP 1637

Query: 850  TVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPA 909
            T   V P ++  S   P      A +  K  + + +            A    P    P 
Sbjct: 1638 TSPPVTPSSLKDSPTSP------ASVTCKMGATVPQ------------ASKGLPAKKGPT 1679

Query: 910  SWKYSSNVRAP--PPVAYNPIH-SPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMK 966
            + K      AP   P+   P    P    ++  S P    PS     KG  PL+ +    
Sbjct: 1680 ALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKG--PLSTV---- 1733

Query: 967  HQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNV-QASSVY 1025
                   A L   Q   +K    + +S      LA  ++    P+ AA+   V       
Sbjct: 1734 -----APAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESA 1788

Query: 1026 SVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSS 1065
            SV A  SPP      S P++ SPVP      PKQ+   SS
Sbjct: 1789 SVSAAPSPP-----VSLPLAPSPVPT---LPPKQQFLPSS 1820



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 123/536 (22%), Positives = 169/536 (31%), Gaps = 83/536 (15%)

Query: 602  PFSPTRNMTSPIADFPAPP--PYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPA 659
            P  PT +   P+A  P     P + +   P+     +   +  P+ PP    P       
Sbjct: 699  PLVPTASENCPVAPSPQNTCAPLATLVLAPE-----IPKSVPSPSLPPAGTPPGTKKVDG 753

Query: 660  FYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEP---KVSPNPELLSLLQN 716
               +S            P + +G    A  + T   +     P    VSP  +     + 
Sbjct: 754  ISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKG 813

Query: 717  SEGKRGTGAGGDSGP----EEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQP 772
            S G   T  G  S P    E  +L   + +    + S A   +P P +PK A   S+  P
Sbjct: 814  SAGP-DTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTP 872

Query: 773  VTPVSPVWSPGVAPT----------QPPAFP-----------TSNPSKGTVVSSIK---- 807
            ++P      P   PT          + PA P           +S+P K     + K    
Sbjct: 873  LSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPA 932

Query: 808  IAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQP------GAVGP 861
               P   P  PA+T     P  GP  A  S  + P P  +TP      P      GA  P
Sbjct: 933  SPSPKGAPTPPAAT--PPSPKGGP--ATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTP 988

Query: 862  SNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAAR-----AQSPTPSLPASWKYSSN 916
                P     G    + + +     V       + AA      A +P  + P S K S  
Sbjct: 989  PAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPA 1048

Query: 917  V--------RAPPPVAYNPIHSPSYP-LAALKSQPSAAQPSKMGKKKGKKPLNALDVMKH 967
                       P     +P   P+ P L    + P+A  PS  G      P  A      
Sbjct: 1049 ATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAA 1108

Query: 968  QPYQLNASLFT-----------FQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNA-AS 1015
             P      L T             PP  K GL   ++     A     A PP P    A+
Sbjct: 1109 TPPSPKGGLATPPHKGAPTTPAATPPSPKGGL---ATPPPKGAPTTPAATPPSPKGGLAT 1165

Query: 1016 PTNVQASSVYSVPAYTSP-PSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAP 1070
            P    A    + PA T P P       SP  A   P   P SPK   A+ S   AP
Sbjct: 1166 PPPKGAP---TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAP 1218



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 87/340 (25%), Positives = 117/340 (34%), Gaps = 80/340 (23%)

Query: 583  VPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFP-----APPPYSAVTPP--------- 628
            VP  +     P     PATP S  +  +SP A  P     AP P   + PP         
Sbjct: 1555 VPSPKKTPAIPTPKEAPATPSS--KEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKE 1612

Query: 629  -PDAFSRGVSSPIAGPAQPPP--WPQPAPWSQPAFYDSSERIASRDERIS---------V 676
             P   +    SP  GPA P P   P   P +  +  DS    AS   ++          +
Sbjct: 1613 APTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGL 1672

Query: 677  PAKR----------------TGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGK 720
            PAK+                T I+    R+       +   P + P+P   S    S+G 
Sbjct: 1673 PAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDP---SAKNGSKGP 1729

Query: 721  RGTGAGGDSGPEEDYLSLGAEACNFMQSSS-------AKQKTP------PPVAPKPAVKS 767
              T A     P +   S  A+  +   S         +K  TP        V PKP   S
Sbjct: 1730 LSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESAS 1789

Query: 768  SSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYP----------PAR 817
             S+ P  PVS   +P   PT PP       S G V+ S     PS P          P  
Sbjct: 1790 VSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLES-----PSKPLAPADEDELLPLI 1844

Query: 818  PASTLNVAGPFKGPQAAVASQNYTPKPT-VSTPTVNAVQP 856
            P   ++   PF+    +V     TPK   +  PT +A QP
Sbjct: 1845 PPEPISGGVPFQ----SVLVNMPTPKSAGIPVPTPSAKQP 1880



 Score = 37.0 bits (84), Expect = 0.10
 Identities = 101/464 (21%), Positives = 164/464 (35%), Gaps = 64/464 (13%)

Query: 637  SSPIAGPAQPPPWP-----QPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRS 691
            S   AGP  PP +P       AP  Q +F        +    +S P  +T  +      S
Sbjct: 289  SQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDH----S 344

Query: 692  TTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGG-DSGPEEDYLSLGAEACNFMQSSS 750
            +T   +  +   + P P    ++  +       A   D GP     ++ +  C+   S S
Sbjct: 345  STGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPS----TISSITCS--PSGS 398

Query: 751  AKQKTPPPVAPKPAVKSSSSQPVT---------PVSPVWSPGVAPTQP---PAFPTSNPS 798
                T   ++P  ++   SS   T         PVS V +  +  T P    A PT+   
Sbjct: 399  LNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFE 458

Query: 799  KGTVVSSIKIAQPSYPP--ARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQP 856
              T VS         PP  + P S +    P     A VA +   P   V+T     V P
Sbjct: 459  VATCVS---------PPMSSGPISNIEPTSPAALVMAPVAPKE--PSTQVATTLRIPVSP 507

Query: 857  GAVGPSN--ELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYS 914
                P +   LP              S + K+    D     A+   +P     A     
Sbjct: 508  PLPDPEDLKNLPS-------------SVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTK 554

Query: 915  SNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQ--PYQL 972
             +    P V   P +SPS+   +   +   +  + + KK   +PL           P  +
Sbjct: 555  KDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGV 614

Query: 973  NASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTS 1032
            N+S    +  D+  G P  +   + S+L +   +   P+ +A P  V  ++      YT+
Sbjct: 615  NSSASVIKT-DSYAG-PDSAGPLLKSSL-ITPTVAAFPLESADPAGVAPTTAKGTSTYTT 671

Query: 1033 PPSFFAEASSPVSASPVPV---GIPTSPKQESASSSYFVAPRPK 1073
              S F E +  ++    PV    + T P   +AS +  VAP P+
Sbjct: 672  TASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQ 715


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 113/466 (24%), Positives = 162/466 (34%), Gaps = 88/466 (18%)

Query: 621  PYSAVTPPPDAFSRGVSSPIAGPAQPPPW----PQPAPWSQPAFYDSSERIASRDERISV 676
            P    + PPD  S  + +P++ PA PP      P  +P S P      + ++S       
Sbjct: 444  PSRPASTPPD--SPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQ 501

Query: 677  PAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYL 736
                + I+   + +S+  P      P     P L +L   +     T +   + P  +  
Sbjct: 502  APLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETP 561

Query: 737  SLGAEACNFMQSSSAKQKTPPPVAPK----------PAVKSSSSQ--PVTPVSPVWSP-- 782
               A     +Q+  +   TPPP  P           PA+ S   Q  P  P+SP+ +P  
Sbjct: 562  PCPAPCP--LQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPP 619

Query: 783  ------GVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVA 836
                   + P Q P  P ++P     +S +    P  P A     L    PF  P +   
Sbjct: 620  QAPPXLALPPLQAPPSPPASPP----LSPLATPSPQAPNALAVHLLQA--PFSPPPSPPV 673

Query: 837  SQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAH 896
               ++P      P    V P A  PS   P ++    Q+                     
Sbjct: 674  QAPFSP------PASPPVSPSATPPSQAPPSLAAPPLQV--------------------- 706

Query: 897  AARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGK 956
                 SP  S P S   +   +APPP+A  P+  P  P A+    PSA  P ++      
Sbjct: 707  ---PPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAA 763

Query: 957  KPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVN--AA 1014
             P   L V    P  L  S     PP A   L          A    QALP  P +    
Sbjct: 764  PP---LQVPPSPPASLPMSPLAKPPPQAPPAL----------ATPPLQALPSPPASFPGQ 810

Query: 1015 SPTNVQASSVYSVPAYTSPPSFFAEASSPVSASP---VPVGIPTSP 1057
            +P +  AS   S P  T PP      + PV A+P   VP   P SP
Sbjct: 811  APFSPSASLPMS-PLATPPPQ-----APPVLAAPLLQVPPSPPASP 850



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 90/372 (24%), Positives = 126/372 (33%), Gaps = 40/372 (10%)

Query: 584 PMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGP 643
           P+       P S+  P  P +P    + P+   P+PP     TPPP A       P+  P
Sbjct: 575 PLTTPPPETPSSIATPP-PQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAP 633

Query: 644 AQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPK 703
             PP  P  +P + P+    +             A    +LQ       + P+     P 
Sbjct: 634 PSPPASPPLSPLATPSPQAPN-------------ALAVHLLQAPFSPPPSPPVQAPFSPP 680

Query: 704 VSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKP 763
            SP P   S    S+      A     P     S             +   TPPP AP P
Sbjct: 681 ASP-PVSPSATPPSQAPPSLAAPPLQVPPSPPAS----------PPMSPSATPPPQAPPP 729

Query: 764 -AVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPAR-PAST 821
            A       P  P SP  SP   P  PP  P        ++++  +  P  PPA  P S 
Sbjct: 730 LAAPPLQVPPSPPASPPMSPSATP--PPRVP-------PLLAAPPLQVPPSPPASLPMSP 780

Query: 822 LNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQS 881
           L    P   P  A       P P  S P      P A  P + L     +   + A    
Sbjct: 781 LAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLL 840

Query: 882 RMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRA---PPPVAYNPIHSPSYPLAAL 938
           ++      S T+QA   R  +P P    S    +   A   PPP + +P  + S P  A 
Sbjct: 841 QVPPSPPASPTLQA-PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAG 899

Query: 939 KSQPSAAQPSKM 950
            S  + + P ++
Sbjct: 900 HSSSATSTPEEL 911



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 146/631 (23%), Positives = 212/631 (33%), Gaps = 90/631 (14%)

Query: 486  DTTGKGALMFAKRRERMDQITAQKEEDKVGGTPS----REQDAAQTD-GLRTTTSYQRKE 540
            +T  +G    A +R  +     +       GTPS    R   AA T+ GL       R  
Sbjct: 140  ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 199

Query: 541  EESVRTQSSVSK----SYIEVSHGLGHVPQQNGFSGTSETANIQRMV-PMNRTAKPFPGS 595
              +   + SVS     S  E S      P   G      + ++     P++  A+  P +
Sbjct: 200  PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA 259

Query: 596  VNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPW 655
               P  P  P++         P P    A+ PP     R  ++P  GP    P   P+P 
Sbjct: 260  RGTPRAPAHPSQ---------PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS 310

Query: 656  SQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQ 715
               A      R     +  + P   T             P      P   P+P     LQ
Sbjct: 311  GTKA------RPVPPPDNAATPLPAT---------LPPSPPLATPLPLAPPSPSAPPSLQ 355

Query: 716  NSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTP 775
                   T       P +   S+       MQ+  + Q T PP+    ++ S S Q   P
Sbjct: 356  TLPSPPAT------PPSQAPPSMTTPP---MQAPPSLQ-TIPPIQVPHSLTSPSLQ--AP 403

Query: 776  VSPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSY-PPARPASTLNVAGPFKGPQAA 834
             SP+    +  T     PT   +   +  S +  Q S   P+RPAST   + P + P + 
Sbjct: 404  PSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSL 463

Query: 835  VASQNYTPKPTVSTPTVNAV-QPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTV 893
             AS    P  T  +P V+ +  P  + P   L  ++          Q+ +   ++     
Sbjct: 464  PAS---PPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSP------QAPLSSLIMPPLET 514

Query: 894  QAHAA--RAQSPTPSLPASWKYSSNVRAPPPV--AYNPIHSPSY---------PLAALKS 940
            Q+  A    Q+P  SL      +    APPP+  A  P+ +P           PL A  S
Sbjct: 515  QSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPS 574

Query: 941  QPSAAQPSKMGKKKGKKPLNALDVMKHQPYQ----LNASLFTFQPPDAKDGLPQKSSVKV 996
             P    P +        P  A   +   P Q       S     PP A    P   ++  
Sbjct: 575  -PLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQA----PPXLALPP 629

Query: 997  NSALAMKQALPP-RPVNAASPTNVQASSVYSVPAYTSPP-------SFFAEASSPVSASP 1048
              A     A PP  P+   SP    A +V+ + A  SPP        F   AS PVS S 
Sbjct: 630  LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA 689

Query: 1049 VPVGIPTSPKQESASSSYFVAPRPKFSAKKS 1079
             P   P+      A+    V P P  S   S
Sbjct: 690  TP---PSQAPPSLAAPPLQVPPSPPASPPMS 717



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 120/544 (22%), Positives = 188/544 (34%), Gaps = 100/544 (18%)

Query: 595  SVNQPATPFSPTRNMTSPIADFPAPPPYSAV---TPPPDAFSRGVSSPIAGPAQPPPWPQ 651
            ++ + A    PTR+  +   +  + PP S      PP    S G   P++ P +     +
Sbjct: 69   TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPG---PVSSPGRASGTTR 125

Query: 652  PAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRST------------------- 692
            P P  Q     S+E   +R +    P KR+ +   A+R ++                   
Sbjct: 126  PGPLGQKGLRISAEETVARGKATEAP-KRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184

Query: 693  -------TKPMFTFKEPKVSPNPELLSLLQNS-------EGKRGTGAGGDSGPEEDYLSL 738
                     P    + P   P   + S  ++S         +R +  GG   P    LS 
Sbjct: 185  TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSS 244

Query: 739  GAEACNF-------------------------MQSSSAKQKTPPPVAPKPAVKSSSSQPV 773
             A   +                          +Q+    Q TPP     PA+   SS P+
Sbjct: 245  SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPL 304

Query: 774  TPVSPVWSPGVAPTQPP-----AFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPF 828
               SP  +    P  PP       P + P    + + + +A PS  P+ P S   +  P 
Sbjct: 305  ATPSPSGTK-ARPVPPPDNAATPLPATLPPSPPLATPLPLAPPS--PSAPPSLQTLPSPP 361

Query: 829  KGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVV 888
              P +       TP P  + P++  + P  V  S   P +    + L     S      +
Sbjct: 362  ATPPSQAPPSMTTP-PMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPL--ALSSLQATTSL 418

Query: 889  DSDTVQA-HAARAQSPTPSLPASWKYSSNVRAPP--PVAYNPIHSPSYPLAALKSQPSAA 945
             S T+QA H+    SP  +  +    S     PP  P    P+  P+ P       P+  
Sbjct: 419  GSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAV- 477

Query: 946  QPSKMGKKKGKKPLNAL-DVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQ 1004
              S +       PL AL  +  H P    +SL    PP     L  +SS+   S      
Sbjct: 478  --SPLSSPLTIHPLQALSSLASHSPQAPLSSL--IMPP-----LETQSSLAPPSLQTPPA 528

Query: 1005 ALPPRPV----NAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQE 1060
            +L   P+    + A P    AS+  + P   +PP     A  P+ A P P+   T+P  E
Sbjct: 529  SLTTPPLENLPSLAPPPLQTASAPLTTPHLETPP---CPAPCPLQAPPSPL---TTPPPE 582

Query: 1061 SASS 1064
            + SS
Sbjct: 583  TPSS 586



 Score = 30.8 bits (68), Expect = 7.3
 Identities = 69/320 (21%), Positives = 113/320 (35%), Gaps = 41/320 (12%)

Query: 754  KTPPPVAPKPAVKSSSSQPVTPVS--PVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQP 811
            + P  + P+P        PVTP +   + + G    +P A         T+  S     P
Sbjct: 20   RAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESA----P 75

Query: 812  SYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGR 871
               P R A T +   P   P A+   +   P    S   V++  PG    +     +  +
Sbjct: 76   RAGPTRSAGTSS-RNPASRPPASGRGERAPPAKNTSPGPVSS--PGRASGTTRPGPLGQK 132

Query: 872  GAQLFAKRQSRMEKYVV--DSDTVQAHAARAQS-PTPSLPA------SWKYSSNVRAPPP 922
            G ++ A+      K         + A A R  S PTP  P+      S    + V  P P
Sbjct: 133  GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRP 192

Query: 923  VAYN----PIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFT 978
                    P   P   +++  S+ S  +PS   +++   P     + +     L++S   
Sbjct: 193  APSARPRPPTEGPRKSVSSA-SEHSTTEPSPAARRR---PSAGGGLQRPASRSLSSSATP 248

Query: 979  FQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFA 1038
               P A+ G   + + +         A P +P     P  +QA      P  T P    A
Sbjct: 249  LSSP-ARSGPSARGTPRA-------PAHPSQP----KPKGLQA---LRPPQVTPPRKDAA 293

Query: 1039 EASSPVSASPVPVGIPTSPK 1058
             A  P+S+SP+    P+  K
Sbjct: 294  PALGPLSSSPLATPSPSGTK 313


>gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]
          Length = 487

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 51/183 (27%), Positives = 82/183 (44%), Gaps = 40/183 (21%)

Query: 9   ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
           +S+ G APWGFRLQGGK+   PL ++ +++  KA+ + +  GD V+SI+G     +T+ E
Sbjct: 6   VSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLE 65

Query: 69  VIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQC 128
               ++  T SL M ++R S+                        E   +Q +P   + C
Sbjct: 66  AQNKIKGCTGSLNMTLQRASAAPKP--------------------EPVPVQ-KPTVTSVC 104

Query: 129 TEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGP----------SYQRAPQMPDSQRGRV 178
           +E       T   LAE QR G    G  K++ GP           +   P   D+ + R+
Sbjct: 105 SE-------TSQELAEGQRRGSQ--GDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRL 155

Query: 179 AEE 181
            E+
Sbjct: 156 IED 158


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 855

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 120/501 (23%), Positives = 175/501 (34%), Gaps = 53/501 (10%)

Query: 588  TAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPP 647
            T+ P PG+   P+   +            P P P +   PP +   + VSS         
Sbjct: 164  TSGPTPGT---PSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSS---ASEHST 217

Query: 648  PWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPN 707
              P PA   +P+     +R ASR    S+ +  T +   A+   + +           P 
Sbjct: 218  TEPSPAARRRPSAGGGLQRPASR----SLSSSATPLSSPARSGPSARGTPRAPAHPSQPK 273

Query: 708  PELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKS 767
            P+ L  L+  +    T    D+ P    LS    A     S++ + + PP +   P   S
Sbjct: 274  PKGLQALRPPQV---TPPRKDAAPALGPLSSSPLATP-SPSAALQSQAPPTLPATPHSSS 329

Query: 768  SSSQPVTPVSPVWSPGVAPTQPPAF------PTSNPSKGTVV--SSIKIAQPSYPPARPA 819
             + Q  TP+ P+  P  +P+ PP+       P + PS+ T    S    A  S+ P+ P 
Sbjct: 330  LTCQLATPL-PLAPP--SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPL 386

Query: 820  STLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKR 879
            S L    P   P  A+      P P  S P      P    P+              A  
Sbjct: 387  SPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPN------------ALAVH 434

Query: 880  QSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALK 939
              +       S  VQA      SP  S P S   +   +APP +A  P+  P  P A+  
Sbjct: 435  LLQAPFSPPPSPPVQAPF----SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPP 490

Query: 940  SQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQ-KSSVKVNS 998
              PSA  P +        PL     +   P Q   +L T  PP     LP   +S    +
Sbjct: 491  MSPSATPPPQAPPPLAAPPLQ----LAKPPPQAPPALAT--PP--LQALPSPPASFPGQA 542

Query: 999  ALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPK 1058
              +   +LP  P+    P   QA  V + P    PPS  A  +      P   G  TS  
Sbjct: 543  PFSPSASLPMSPLATPPP---QAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVS 599

Query: 1059 QESASSSYFVAPRPKFSAKKS 1079
                + +    P P  S   S
Sbjct: 600  GPRLTLALAPGPPPPPSRSPS 620



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 108/479 (22%), Positives = 165/479 (34%), Gaps = 51/479 (10%)

Query: 595  SVNQPATPFSPTRNMTSPIADFPAPPPYSAV---TPPPDAFSRGVSSPIAGPAQPPPWPQ 651
            ++ + A    PTR+  +   +  + PP S      PP    S G   P++ P +     +
Sbjct: 69   TIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPG---PVSSPGRASGTTR 125

Query: 652  PAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELL 711
            P P  Q     S+E   +R +    P  +   L    RR T+ P         +P+P + 
Sbjct: 126  PGPLGQKGLRISAEETVARGKATEAP--KRSALSAGARRDTSGP------TPGTPSPAMA 177

Query: 712  SLLQNSEGKRGTGAGGDS--------GPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKP 763
               + +  + G      S        GP +   S    +      ++ ++ +      +P
Sbjct: 178  RRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 237

Query: 764  AVKSSSSQPVTPVSPVWSPGVAPTQP--PAFPTSNPSKGTVVSSIKIAQPSYPPARPAST 821
            A +S SS      SP  S   A   P  PA P+    KG          P    A PA  
Sbjct: 238  ASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG 297

Query: 822  LNVAGPFKGPQAAVASQNYTPKPTVSTP-----TVNAVQPGAVGPSNELPGMSGRGAQLF 876
               + P   P  + A Q+  P    +TP     T     P  + P +     S +     
Sbjct: 298  PLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSP 357

Query: 877  AKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLA 936
                       + S T+QA      S  PS P S   +   +APP +A  P+ +P  P A
Sbjct: 358  PATPPSQATTSLGSPTLQA----THSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPA 413

Query: 937  ALKSQPSAAQPSKMGKKKGKKPLNALDV-MKHQPYQLNASLFTFQPPDAKDGLPQKSSVK 995
            +    P  A PS           NAL V +   P+    S     P       P   S  
Sbjct: 414  SPPLSP-LATPSPQAP-------NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT 465

Query: 996  VNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIP 1054
              S      A PP  V  + P +   S     P+ T PP    +A  P++A P+ +  P
Sbjct: 466  PPSQAPPSLAAPPLQVPPSPPASPPMS-----PSATPPP----QAPPPLAAPPLQLAKP 515



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 100/422 (23%), Positives = 145/422 (34%), Gaps = 60/422 (14%)

Query: 573 TSETANIQRMVPMNRTAKPFPGSV-NQPATPFSP-TRNMTSPIAD-----FPAPPPYSAV 625
           T + A    + P + +A P   ++ + PATP S  T ++ SP         P+PP     
Sbjct: 331 TCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLA 390

Query: 626 TPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQ 685
           TPPP A       P+  P  PP  P  +P + P+    +             A    +LQ
Sbjct: 391 TPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPN-------------ALAVHLLQ 437

Query: 686 EAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGG----DSGPEEDYLSLGA- 740
                  + P+     P  SP P   S    S+      A       S P    +S  A 
Sbjct: 438 APFSPPPSPPVQAPFSPPASP-PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSAT 496

Query: 741 ---EACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPA------ 791
              +A   + +   +   PPP AP PA+ +   Q + P  P   PG AP  P A      
Sbjct: 497 PPPQAPPPLAAPPLQLAKPPPQAP-PALATPPLQAL-PSPPASFPGQAPFSPSASLPMSP 554

Query: 792 FPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYT---------- 841
             T  P    V+++  +  P  PPA P        P  GP  +V+    T          
Sbjct: 555 LATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 614

Query: 842 ----PKPTVSTPTVNAVQPGAVGPSNELPGM-SGRGAQLFAKRQSRMEKYVVDSDTVQAH 896
               P  T+S P +      A     EL G  SG      A           D++    H
Sbjct: 615 PSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPP-------DAELAACH 667

Query: 897 AARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGK 956
            A A S  P+ P +++ +     P P A  P  +           P +A P+      G 
Sbjct: 668 PA-AWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGP 726

Query: 957 KP 958
            P
Sbjct: 727 SP 728



 Score = 37.4 bits (85), Expect = 0.078
 Identities = 79/337 (23%), Positives = 116/337 (34%), Gaps = 71/337 (21%)

Query: 574 SETANIQRMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAP---PPYSAVTPPPD 630
           S +A      P +  A P     + PA+P  P     +P    P P   PP     PPP 
Sbjct: 461 SPSATPPSQAPPSLAAPPLQVPPSPPASP--PMSPSATPPPQAPPPLAAPPLQLAKPPPQ 518

Query: 631 AFSRGVSSPI-AGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISV------------P 677
           A     + P+ A P+ P  +P  AP+S  A    S       +   V            P
Sbjct: 519 APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPP 578

Query: 678 AKRTGILQEAKRRSTTKPMFTFKEPKVS-------PNPELLSLLQNSEGK--RGTGAGGD 728
           A  T  LQ  +R  T  P  +   P+++       P P   S      G    G  +   
Sbjct: 579 ASPT--LQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT 636

Query: 729 SGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQ 788
           S PEE            ++   +  +     +P P  + ++  P       WS G AP  
Sbjct: 637 STPEE------------LRGYDSGPEGGAAASPPPDAELAACHPA-----AWSRGPAP-- 677

Query: 789 PPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVST 848
           P AF                  P  P   P +T    GP  G    + +   T  P  +T
Sbjct: 678 PLAFR---------------GAPGAPLPWPPAT----GP--GSADGLCTIYETEGPESAT 716

Query: 849 PTVNAVQPG-AVGPS-NELPGMSGRGAQLFAKRQSRM 883
           P   A+ PG + G S  +    +G GA   + +Q+R+
Sbjct: 717 PAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARL 753


>gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]
          Length = 234

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 47/160 (29%), Positives = 74/160 (46%), Gaps = 30/160 (18%)

Query: 9   ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
           +S+ G APWGFRLQGGK+   PL ++ +++  KA+ + +  GD V+SI+G     +T+ E
Sbjct: 6   VSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLE 65

Query: 69  VIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQC 128
               ++  T SL M ++R S+                        E   +Q +P   + C
Sbjct: 66  AQNKIKGCTGSLNMTLQRASAAPKP--------------------EPVPVQ-KPTVTSVC 104

Query: 129 TEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAP 168
           +E       T   LAE QR G    G  K++ G    + P
Sbjct: 105 SE-------TSQELAEGQRRGSQ--GDSKQQNGKIPPKRP 135


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 139/559 (24%), Positives = 192/559 (34%), Gaps = 137/559 (24%)

Query: 542  ESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPAT 601
            ES    S+ S S +  +   GHV  Q+  S     A  +R   +  ++K    S+N+P T
Sbjct: 545  ESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEA-WKRGTQLEESSKARMESMNRPYT 603

Query: 602  ----PFSPTRNMTSPI-ADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWS 656
                P SP   + +P  A  P+PP      PPP             P  PPP P P P  
Sbjct: 604  SLVPPLSPQPKIVTPYTASQPSPP-----LPPP-------------PPPPPPPPPPPPPP 645

Query: 657  QPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQN 716
             P                 +P+      Q A    +  PMF             ++ LQN
Sbjct: 646  PP----------------PLPS------QSAPSAGSAAPMFV--------KYSTITRLQN 675

Query: 717  SEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQK---------TPPPVAPKPAVKS 767
            +    G      + P              MQS S K +          PPP  P P    
Sbjct: 676  ASQHSGALFKPPTPP-------------VMQSQSVKPQILVPPNGVVPPPPPPPPPPTPG 722

Query: 768  SSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVSSI-KIAQPSYPPARPASTLNVAG 826
            S+   + P         AP+ P       P K   V  I ++A P+ PP  P     +  
Sbjct: 723  SAMAQLKPAP------CAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPP-----IPA 771

Query: 827  PFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKY 886
            P   PQA        P PT ST TV  V   A  P+   P    +      K+ +    Y
Sbjct: 772  PLP-PQAPPKPLVTIPAPT-STKTVAPVVTQAAPPTPTPPVPPAK------KQPAFPASY 823

Query: 887  VVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLA---------- 936
            +  S            P P+LP   K  S    PPP   +P+ S    +A          
Sbjct: 824  IPPSPPTPP----VPVPPPTLP---KQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPP 876

Query: 937  ALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKV 996
            A++SQP    P+ +     + P       K QP  +      F PP      P+ S V  
Sbjct: 877  AMESQPLKPVPANVAP---QSPPAVKAKPKWQPSSIPVPSPDFPPPP-----PESSLVFP 928

Query: 997  NSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTS 1056
                +   A PP P   ASPT  ++          SP    ++ SSP    P     P +
Sbjct: 929  PPPPSPVPAPPPPPPPTASPTPDKSG---------SPGKKTSKTSSPGGKKP-----PPT 974

Query: 1057 PKQESA--SSSYFVAPRPK 1073
            P++ S+  SSS    P PK
Sbjct: 975  PQRNSSIKSSSGAEHPEPK 993



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 119/528 (22%), Positives = 169/528 (32%), Gaps = 66/528 (12%)

Query: 574  SETANIQRMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFS 633
            S++   Q +VP N    P P     P TP S    +  P    P+ P +SA  PP     
Sbjct: 694  SQSVKPQILVPPNGVVPP-PPPPPPPPTPGSAMAQL-KPAPCAPSLPQFSAPPPPLKIHQ 751

Query: 634  RGVSSPIAGPAQPPPWPQPAPWSQPAF--------YDSSERIASRDERISVPAKRTGILQ 685
                + +A P  PPP P PAP    A           +S +  +     + P   T  + 
Sbjct: 752  VQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVP 811

Query: 686  EAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNF 745
             AK++      +    P   P P     L   +            P    LS        
Sbjct: 812  PAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAK-------PPPSPLSPVPSVVKQ 864

Query: 746  MQSSSAKQKTPP-----PVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKG 800
            + S      TPP     P+ P PA  +  S P     P W P                  
Sbjct: 865  IASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQP------------------ 906

Query: 801  TVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVG 860
               SSI +  P +PP  P S+L    P   P + V +    P PT S     +  PG   
Sbjct: 907  ---SSIPVPSPDFPPPPPESSLVFPPP---PPSPVPAPPPPPPPTASPTPDKSGSPGKKT 960

Query: 861  PSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAP 920
                 PG  G+      +R S      + S +   H    +    SL + +   +   +P
Sbjct: 961  SKTSSPG--GKKPPPTPQRNSS-----IKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSP 1013

Query: 921  PPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPL---NALDVMKHQPYQLNASLF 977
                  P  +P  P     S  +     + G    K P+      D +   P   + S F
Sbjct: 1014 SKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDF 1073

Query: 978  TFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPS-- 1035
               PP+ +  LP      V S        P   V    P      SV   P  T P    
Sbjct: 1074 PPPPPETELPLPPIEIPAVFSG----NTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRND 1129

Query: 1036 ----FFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKS 1079
                  AE S   + + V   +PTSPK   +    F+A   +   +KS
Sbjct: 1130 STRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKS 1177



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 72/328 (21%), Positives = 111/328 (33%), Gaps = 28/328 (8%)

Query: 757  PPVAPKPAV-----KSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQP 811
            PP++P+P +      S  S P+ P  P   P   P  PP  P  + S  +  S+  +   
Sbjct: 607  PPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVK 666

Query: 812  SYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGR 871
                 R  +    +G    P      Q+ + KP +  P    V P    P    PG S  
Sbjct: 667  YSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPG-SAM 725

Query: 872  GAQLFAKRQSRMEKYVVDSDTVQ----AHAARAQSPTPSLPASWKYSSNVRAPPPVAYNP 927
                 A     + ++      ++     H  +   PTP  P           PP  A  P
Sbjct: 726  AQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPP-----------PPIPAPLP 774

Query: 928  IHSPSYPLAALKSQPSAAQPSKMGKKKG-KKPLNALDVMKHQPYQLNASLFTFQPPDAKD 986
              +P  PL  + +  S    + +  +     P   +   K QP    AS     PP    
Sbjct: 775  PQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQP-AFPASYIPPSPPTPPV 833

Query: 987  GLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSA 1046
             +P  +  K  S  A     PP P++       Q +S +  P   +PP+  ++   PV A
Sbjct: 834  PVPPPTLPKQQSFCAKP---PPSPLSPVPSVVKQIASQFPPP--PTPPAMESQPLKPVPA 888

Query: 1047 SPVPVGIPTSPKQESASSSYFVAPRPKF 1074
            +  P   P    +     S    P P F
Sbjct: 889  NVAPQSPPAVKAKPKWQPSSIPVPSPDF 916


>gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens]
          Length = 330

 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 59/218 (27%), Positives = 96/218 (44%), Gaps = 30/218 (13%)

Query: 9   ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
           +++TG  PWGFRLQGGK+   PL +++I   SKA+ S L +GD VV+I+G     +T+ E
Sbjct: 5   VTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLE 64

Query: 69  VIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQC 128
               ++S + +L + +++    I  +  +      L  + H         Q  PA  T  
Sbjct: 65  AQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPH---------QKDPALDTNG 115

Query: 129 TEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAEELILREKV 188
           +    +P       +   R+ P   G+   E  P++  A   P +               
Sbjct: 116 SLVAPSP-------SPEARASPGTPGT--PELRPTFSPAFSRPSA----------FSSLA 156

Query: 189 EAVQPGPV-VELQLSLSQERHKGASGPLVALPGAEKSK 225
           EA  PGP    L+   S E  +   GP  ALPG+ + +
Sbjct: 157 EASDPGPPRASLRAKTSPEGARDLLGP-KALPGSSQPR 193


>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
          Length = 727

 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 59/218 (27%), Positives = 96/218 (44%), Gaps = 30/218 (13%)

Query: 9   ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
           +++TG  PWGFRLQGGK+   PL +++I   SKA+ S L +GD VV+I+G     +T+ E
Sbjct: 5   VTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLE 64

Query: 69  VIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQC 128
               ++S + +L + +++    I  +  +      L  + H         Q  PA  T  
Sbjct: 65  AQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPH---------QKDPALDTNG 115

Query: 129 TEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAEELILREKV 188
           +    +P       +   R+ P   G+   E  P++  A   P +               
Sbjct: 116 SLVAPSP-------SPEARASPGTPGT--PELRPTFSPAFSRPSA----------FSSLA 156

Query: 189 EAVQPGPV-VELQLSLSQERHKGASGPLVALPGAEKSK 225
           EA  PGP    L+   S E  +   GP  ALPG+ + +
Sbjct: 157 EASDPGPPRASLRAKTSPEGARDLLGP-KALPGSSQPR 193



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 25/78 (32%), Positives = 33/78 (42%), Gaps = 9/78 (11%)

Query: 584 PMNRTAKPFPGSVNQPATPFSPTRNMTSPIADF-PAPPPYSAVTPPPD---AFSRGVSSP 639
           P   T  P P     PA  ++P     SP+  + P+P P    +P P+   A S   S  
Sbjct: 426 PTPYTPSPAPAYTPSPAPAYTP-----SPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGG 480

Query: 640 IAGPAQPPPWPQPAPWSQ 657
            A PA  PPW     +SQ
Sbjct: 481 PAEPASRPPWVTDDSFSQ 498


>gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]
          Length = 214

 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 31/81 (38%), Positives = 51/81 (62%)

Query: 9  ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
          +S+ G APWGFRLQGGK+   PL ++ +++  KA+ + +  GD V+SI+G     +T+ E
Sbjct: 6  VSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLE 65

Query: 69 VIKLMESITDSLQMLIKRPSS 89
              ++  T SL M ++R S+
Sbjct: 66 AQNKIKGCTGSLNMTLQRASA 86


>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
          Length = 596

 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 31/81 (38%), Positives = 51/81 (62%)

Query: 9  ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
          +S+ G APWGFRLQGGK+   PL ++ +++  KA+ + +  GD V+SI+G     +T+ E
Sbjct: 6  VSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLE 65

Query: 69 VIKLMESITDSLQMLIKRPSS 89
              ++  T SL M ++R S+
Sbjct: 66 AQNKIKGCTGSLNMTLQRASA 86


>gi|222352122 hypothetical protein LOC284297 [Homo sapiens]
          Length = 1573

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 110/502 (21%), Positives = 175/502 (34%), Gaps = 74/502 (14%)

Query: 594  GSVNQPATPFSPTRNMTSPIADFPAPP-----PYSAVTPPPDAFSRGVSSPIA------- 641
            G    P  P+ P R    P A   APP     P ++  PP  A +   S  +        
Sbjct: 980  GDTGSPRKPW-PERRPPRPAATRTAPPTPSPGPSASPGPPGPALTSDSSRELTPHSALTS 1038

Query: 642  -----GPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPM 696
                  P   PP P PA  + P        + S D  +S P   + ++       +  P+
Sbjct: 1039 EATSDAPDTSPPTPDPASRTNPDLI-----LTSPDFALSTPD--SSVVPALTPEPSPTPL 1091

Query: 697  FTF-KEPKVSPNP--ELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQ 753
             T  KE    P+   E+ SL   SE    +    D+ P+ D     +    + +S     
Sbjct: 1092 PTLPKELTSDPSTPSEVTSLSPTSEQVPES----DTTPDLDTTPYSSTVSEYSRSPDPSP 1147

Query: 754  KTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSY 813
               P   P P +   +  P+T ++P  +P   PT P   PT+ P   T+  S  I  P+ 
Sbjct: 1148 SPHPTTTPDPTM---APDPITTLNPTVTPHF-PTTP--HPTTTPHPTTITHSTMIPDPTT 1201

Query: 814  PPARPASTLN----VAGPFKGPQAAVASQ-NYTPKPTVSTPTVNAVQPGAVGPSNELPGM 868
             P +P +T+     +  P   PQ     Q   TP  T   PT     P  +  S  +P  
Sbjct: 1202 TP-QPFTTITHSTMIPDPTTTPQPFTTMQPTTTPHSTTPHPTTTP-HPTTITHSTMIPDP 1259

Query: 869  SGRGAQLFAKRQSRM-EKYVVDSDTVQAHAARAQSPT----PSL---PASWKYSSNV--- 917
            +         + + M         T   H      PT    P++   P +  Y +     
Sbjct: 1260 TTTPQPFTTMQPTTMPHPTTTPHPTTTPHPTTTPHPTTTPHPTMTPDPTTTPYPTTTPDP 1319

Query: 918  -RAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNA-LDVMKHQPYQLNAS 975
               P P   +P  +P     +L +       S       K  L+  L      P+   + 
Sbjct: 1320 TTTPHPTTPDPSSTPVITTVSLPTSLGTELSSPTLAPTVKPSLHPQLTFTAPAPHTSTSQ 1379

Query: 976  LFTFQPPDAKDGLPQKSSVKVN-SALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPP 1034
            + T +P  A +  P +SS   +   L+ +   PPR  +               P  T PP
Sbjct: 1380 IPTLEPSPALESSPSRSSTATSMDPLSTEDFKPPRSQS---------------PNLTPPP 1424

Query: 1035 SFFAEASSPVSASPVPVGIPTS 1056
            +    ++S ++ SP P+  PT+
Sbjct: 1425 THTPHSASDLTVSPDPLLSPTA 1446



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 61/237 (25%), Positives = 80/237 (33%), Gaps = 44/237 (18%)

Query: 576  TANIQRMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRG 635
            T   Q    M  T  P P +   P T   PT   T+P    P   P+  +TP P      
Sbjct: 1260 TTTPQPFTTMQPTTMPHPTTTPHPTTTPHPT---TTP---HPTTTPHPTMTPDPTTTPYP 1313

Query: 636  VSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKP 695
             ++P   P   P    P P S P               +S+P      L       T KP
Sbjct: 1314 TTTP--DPTTTPHPTTPDPSSTPVI-----------TTVSLPTSLGTELSSPTLAPTVKP 1360

Query: 696  ------MFTFKEPKVS----PNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNF 745
                   FT   P  S    P  E    L++S  +  T    D    ED+    +++ N 
Sbjct: 1361 SLHPQLTFTAPAPHTSTSQIPTLEPSPALESSPSRSSTATSMDPLSTEDFKPPRSQSPNL 1420

Query: 746  MQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAP-TQPPAFP-TSNPSKG 800
                     TPPP        S+S   V+P  P+ SP   P   PP  P T  P+ G
Sbjct: 1421 ---------TPPPT---HTPHSASDLTVSP-DPLLSPTAHPLDHPPLDPLTLGPTPG 1464



 Score = 35.0 bits (79), Expect = 0.39
 Identities = 56/302 (18%), Positives = 99/302 (32%), Gaps = 33/302 (10%)

Query: 573  TSETANIQRMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADF--PAPPPYSAVTPPPD 630
            TS+ +    +  ++ T++  P S   P    +P  +  S  +    P+P P+   TP P 
Sbjct: 1099 TSDPSTPSEVTSLSPTSEQVPESDTTPDLDTTPYSSTVSEYSRSPDPSPSPHPTTTPDPT 1158

Query: 631  AFSRGVS--SPIAGPAQPPPWPQPAPWSQPAFYDSSERI----------ASRDERISVPA 678
                 ++  +P   P   P  P P     P     S  I           +      +P 
Sbjct: 1159 MAPDPITTLNPTVTP-HFPTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTITHSTMIPD 1217

Query: 679  KRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSL 738
              T        + TT P  T   P  +P+P  ++          T     +   + + ++
Sbjct: 1218 PTTTPQPFTTMQPTTTPHSTTPHPTTTPHPTTIT--------HSTMIPDPTTTPQPFTTM 1269

Query: 739  GAEACNFMQSSSAKQKTP-PPVAPKPAV---KSSSSQPVTPVSPVWSPGVAPTQPPAFPT 794
                     ++     TP P   P P      + +  P T   P  +P   PT  P   T
Sbjct: 1270 QPTTMPHPTTTPHPTTTPHPTTTPHPTTTPHPTMTPDPTTTPYPTTTPD--PTTTPHPTT 1327

Query: 795  SNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAV 854
             +PS   V++++ +           +      P   PQ    +    P P  ST  +  +
Sbjct: 1328 PDPSSTPVITTVSLPTSLGTELSSPTLAPTVKPSLHPQLTFTA----PAPHTSTSQIPTL 1383

Query: 855  QP 856
            +P
Sbjct: 1384 EP 1385


>gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]
          Length = 283

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 30/78 (38%), Positives = 51/78 (65%)

Query: 9  ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
          +++TG  PWGFRLQGGK+   PL +++I   SKA+ S L +GD VV+I+G     +T+ E
Sbjct: 5  VTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLE 64

Query: 69 VIKLMESITDSLQMLIKR 86
              ++S + +L + +++
Sbjct: 65 AQNKIKSASYNLSLTLQK 82


>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
          Length = 617

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 30/78 (38%), Positives = 51/78 (65%)

Query: 9  ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
          +++TG  PWGFRLQGGK+   PL +++I   SKA+ S L +GD VV+I+G     +T+ E
Sbjct: 5  VTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLE 64

Query: 69 VIKLMESITDSLQMLIKR 86
              ++S + +L + +++
Sbjct: 65 AQNKIKSASYNLSLTLQK 82



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 25/78 (32%), Positives = 33/78 (42%), Gaps = 9/78 (11%)

Query: 584 PMNRTAKPFPGSVNQPATPFSPTRNMTSPIADF-PAPPPYSAVTPPPD---AFSRGVSSP 639
           P   T  P P     PA  ++P     SP+  + P+P P    +P P+   A S   S  
Sbjct: 316 PTPYTPSPAPAYTPSPAPAYTP-----SPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGG 370

Query: 640 IAGPAQPPPWPQPAPWSQ 657
            A PA  PPW     +SQ
Sbjct: 371 PAEPASRPPWVTDDSFSQ 388



 Score = 31.2 bits (69), Expect = 5.6
 Identities = 30/123 (24%), Positives = 45/123 (36%), Gaps = 11/123 (8%)

Query: 729 SGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPV----WSPGV 784
           S P+    S    A +   + ++  + P   APKP V +++S   +   PV    +SP  
Sbjct: 251 SRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSP 310

Query: 785 APTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKP 844
                P   T +P+     S      PS  P    S      P   P       NY P P
Sbjct: 311 GANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAP-------NYNPAP 363

Query: 845 TVS 847
           +V+
Sbjct: 364 SVA 366


>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
          Length = 2089

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 146/634 (23%), Positives = 239/634 (37%), Gaps = 77/634 (12%)

Query: 482  EMLPDTTGKGALMFAKRRERMDQI----TAQKEEDKVG--GTPSREQDAAQTDGLRTTTS 535
            E   D TG+  L   K+     Q+    T ++E DK G   +P R++++ + + + T+  
Sbjct: 841  ERQTDVTGEEELTKGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVE-IETSEE 899

Query: 536  YQRKEEESVRTQSSVSKSYI-EVSHGLGHVPQQNGFSGTSETANIQRMVPM------NRT 588
             Q K+   V+ Q+  SK++  EV   + +           + A ++  VP        + 
Sbjct: 900  IQEKQ---VQKQTLPSKAFEREVERPVAN--------RECDPAELEEKVPKVILERDTQR 948

Query: 589  AKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPA-QPP 647
             +P  GS +Q     SPT        D P P   ++   P  + S G  SP++    Q  
Sbjct: 949  GEPEGGSQDQKGQASSPTPEPGVGAGDLPGP---TSAPVPSGSQSGGRGSPVSPRRHQKG 1005

Query: 648  PWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPN 707
                  P ++ A    +    SR ++ S  A     + EA      KP+ +  +  ++P 
Sbjct: 1006 LLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPA-PPQKPLNSQSQKHLAPP 1064

Query: 708  PELLSLLQNSEGK-RGTGAGGDSGPEEDYLSLGAEACN---FMQSSSAKQKTPPPV---A 760
            P L  LL + +   R T   G     E  LS   E  +    +++  + + TP P    A
Sbjct: 1065 PLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAA 1124

Query: 761  PKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPAS 820
            P+P   +S++QPVTP  P      + T   +  T  P    VV +    QPS    +P +
Sbjct: 1125 PEPHPSTSTAQPVTP-KPTSQATRSRTNRSSVKTPEP----VVPTAPELQPSTSTDQPVT 1179

Query: 821  TLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQ 880
            +   +   +G +    S++    P    PT   +QP     S + P  S   +Q    R+
Sbjct: 1180 SEPTSQVTRGRK----SRSSVKTPETVVPTALELQPST---STDRPVTSEPTSQATRGRK 1232

Query: 881  SRM-----EKYVVDSDTVQAHAARAQ----SPTPSLPASWKYSSNVRAPPPVA-----YN 926
            +R      E  V  +  +Q   +  Q     PT       K  S+V+ P PV        
Sbjct: 1233 NRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELR 1292

Query: 927  PIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKD 986
            P  S   P+    +  +    + M   K  +      V+   P +L  S  T QP     
Sbjct: 1293 PSTSTDRPVTPKPTSRTTRSRTNMSSVKTPE-----TVVPTAP-ELQISTSTDQPV---- 1342

Query: 987  GLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSA 1046
              P+ +S    S   M     P      +P  +  S+    P    P S         S+
Sbjct: 1343 -TPKPTSRTTRSRTNMSSVKNPESTVPIAP-ELPPSTSTEQPVTPEPTSRATRGRKNRSS 1400

Query: 1047 SPVP-VGIPTSPKQE-SASSSYFVAPRPKFSAKK 1078
               P   +PT+PK E S S+   V P P   A +
Sbjct: 1401 GKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATR 1434



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 116/595 (19%), Positives = 200/595 (33%), Gaps = 82/595 (13%)

Query: 518  PSREQDAAQTDGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETA 577
            PS   D   T    +  +  RK   SV+T  +V  + +E+               TSE  
Sbjct: 1170 PSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTS-----TDRPVTSEPT 1224

Query: 578  NIQRMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVS 637
            +       NR++   P  V   A    P+ +   P+    + P Y A     +  S    
Sbjct: 1225 SQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVT---SEPTYQATRGRKNRSSVKTP 1281

Query: 638  SPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRR---STTK 694
             P+  P  P   P  +         +S    SR    SV    T +    + +   ST +
Sbjct: 1282 EPVV-PTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQ 1340

Query: 695  PMFTFKEPKVSPNPELLSLLQNSEGKRGTG-----AGGDSGPEEDYLSLGAEACNFMQSS 749
            P+      + + +   +S ++N E           +     P     +  A      +SS
Sbjct: 1341 PVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSS 1400

Query: 750  SAKQKTPPPVAPKPAVKSSSSQPVT------------------------PVSPVWSPGVA 785
                +T  P APK    +S+ QPVT                        P +P   P  +
Sbjct: 1401 GKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTS 1460

Query: 786  PTQP-PAFPTSNPSKG-TVVSSIKIAQ---PSYPPARPASTLN---VAGPFKGPQAAVAS 837
              QP    PTS  ++G T  SS+K  +   P+ P  + +++ +    + P         +
Sbjct: 1461 TDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKN 1520

Query: 838  QNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQS--RMEKYVVDSDTVQA 895
            ++    P    P    +QP         P  + R  +    R S    E  V  +  +Q 
Sbjct: 1521 RSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQP 1580

Query: 896  HAARAQ----SPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMG 951
              +R Q     PT          S+V+ P PV       P+ P     +        K+ 
Sbjct: 1581 STSRNQLVTPEPTSRATRCRTNRSSVKTPEPVV------PTAPEPHPTTSTDQPVTPKLT 1634

Query: 952  KKKGKKPLNALDVMKHQPYQLNAS-LFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRP 1010
             +  ++  N   V   +P +  AS L  F P D                   +   P   
Sbjct: 1635 SRATRRKTNRSSVKTPKPVEPAASDLEPFTPTD-------------------QSVTPEAI 1675

Query: 1011 VNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSS 1065
                    +++S+V ++P  T+ P F +  ++    SP P+  P+  K++ A+ +
Sbjct: 1676 AQGGQSKTLRSSTVRAMPVPTT-PEFQSPVTTDQPISPEPITQPSCIKRQRAAGN 1729


>gi|118600967 shroom family member 4 [Homo sapiens]
          Length = 1493

 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 32/92 (34%), Positives = 57/92 (61%), Gaps = 2/92 (2%)

Query: 2  GTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKAS-GSGLCEGDEVVSINGNP 60
          G+  ++ + + GGAPWGF L+GG E  +PL V+KI +  KA+    +  GDE+V+ING P
Sbjct: 6  GSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVNINGTP 65

Query: 61 CADLTYPEVIKLMESITDSLQMLIKRPSSGIS 92
              +  E + L++     L+++++R ++ +S
Sbjct: 66 LYG-SRQEALILIKGSFRILKLIVRRRNAPVS 96


>gi|196162711 PDZ and LIM domain 4 isoform 2 [Homo sapiens]
          Length = 246

 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 27/79 (34%), Positives = 47/79 (59%)

Query: 9  ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
          +++ G +PWGFRL GG++   PL ++++   SKA+ + LC GD + +ING     +T+ E
Sbjct: 5  VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64

Query: 69 VIKLMESITDSLQMLIKRP 87
              ++   D L + + RP
Sbjct: 65 AQNRIKGCHDHLTLSVSRP 83


>gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens]
          Length = 330

 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 27/79 (34%), Positives = 47/79 (59%)

Query: 9  ISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPE 68
          +++ G +PWGFRL GG++   PL ++++   SKA+ + LC GD + +ING     +T+ E
Sbjct: 5  VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64

Query: 69 VIKLMESITDSLQMLIKRP 87
              ++   D L + + RP
Sbjct: 65 AQNRIKGCHDHLTLSVSRP 83


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 89/343 (25%), Positives = 120/343 (34%), Gaps = 38/343 (11%)

Query: 746  MQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAF------PTSNPSK 799
            +Q+    Q TPP     PA+   SS P+   SP   P  +P+ PP+       P + PS+
Sbjct: 268  LQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPP--SPSAPPSLQTLPSPPATPPSQ 325

Query: 800  GTVV--SSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPG 857
             T    S    A  S+ P+ P S L    P   P  A+      P P  S P      P 
Sbjct: 326  ATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPS 385

Query: 858  AVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNV 917
               P+              A    +       S  VQA      SP  S P S   +   
Sbjct: 386  PQAPN------------ALAVHLLQAPFSPPPSPPVQAPF----SPPASPPVSPSATPPS 429

Query: 918  RAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLF 977
            +APP +A  P+  P  P A+    PSA  P +        PL     +   P Q   +L 
Sbjct: 430  QAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQ----LAKPPPQAPPALA 485

Query: 978  TFQPPDAKDGLPQ-KSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSF 1036
            T  PP     LP   +S    +  +   +LP  P+    P   QA  V + P    PPS 
Sbjct: 486  T--PP--LQALPSPPASFPGQAPFSPSASLPMSPLATPPP---QAPPVLAAPLLQVPPSP 538

Query: 1037 FAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKS 1079
             A  +      P   G  TS      + +    P P  S   S
Sbjct: 539  PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPS 581



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 110/493 (22%), Positives = 166/493 (33%), Gaps = 48/493 (9%)

Query: 486 DTTGKGALMFAKRRERMDQITAQKEEDKVGGTPS----REQDAAQTD-GLRTTTSYQRKE 540
           +T  +G    A +R  +     +       GTPS    R   AA T+ GL       R  
Sbjct: 131 ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 190

Query: 541 EESVRTQSSVSK----SYIEVSHGLGHVPQQNGFSGTSETANIQRMV-PMNRTAKPFPGS 595
             +   + SVS     S  E S      P   G      + ++     P++  A+  P +
Sbjct: 191 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA 250

Query: 596 VNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPW 655
              P  P  P++         P P    A+ PP     R  ++P  GP    P   P+P 
Sbjct: 251 RGTPRAPAHPSQ---------PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPS 301

Query: 656 SQPAFYDSSERIASRDERISVPAKRTGILQEAKRRST-----TKPMFTFKEPKVSPNPEL 710
           + P+               + P++ T  L     ++T     + P+     P     P L
Sbjct: 302 APPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 361

Query: 711 LSLLQNSEGKRGTGAGGDSGP--EEDYLSLGAEACNFMQSSSAKQKTPPPVAP-----KP 763
              L   +      A     P       +  A A + +Q+  +   +PP  AP      P
Sbjct: 362 --ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 419

Query: 764 AVKSSSSQP-VTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTL 822
            V  S++ P   P S    P   P  PPA P  +PS            P  PP   A  L
Sbjct: 420 PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPS--------ATPPPQAPPPLAAPPL 471

Query: 823 NVA--GPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQ 880
            +A   P   P  A       P P  S P      P A  P + L     +   + A   
Sbjct: 472 QLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPL 531

Query: 881 SRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRA---PPPVAYNPIHSPSYPLAA 937
            ++      S T+QA   R  +P P    S    +   A   PPP + +P  + S P  A
Sbjct: 532 LQVPPSPPASPTLQA-PRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLA 590

Query: 938 LKSQPSAAQPSKM 950
             S  + + P ++
Sbjct: 591 GHSSSATSTPEEL 603



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 95/395 (24%), Positives = 133/395 (33%), Gaps = 59/395 (14%)

Query: 599 PATPFSP-TRNMTSPIAD-----FPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQP 652
           PATP S  T ++ SP         P+PP     TPPP A       P+  P  PP  P  
Sbjct: 319 PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 378

Query: 653 APWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLS 712
           +P + P+    +             A    +LQ       + P+     P  SP P   S
Sbjct: 379 SPLATPSPQAPN-------------ALAVHLLQAPFSPPPSPPVQAPFSPPASP-PVSPS 424

Query: 713 LLQNSEGKRGTGAG----GDSGPEEDYLSLGA----EACNFMQSSSAKQKTPPPVAPKPA 764
               S+      A       S P    +S  A    +A   + +   +   PPP AP PA
Sbjct: 425 ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAP-PA 483

Query: 765 VKSSSSQPVTPVSPVWSPGVAPTQPPA------FPTSNPSKGTVVSSIKIAQPSYPPARP 818
           + +   Q + P  P   PG AP  P A        T  P    V+++  +  P  PPA P
Sbjct: 484 LATPPLQAL-PSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASP 542

Query: 819 ASTLNVAGPFKGPQAAVASQNYT--------------PKPTVSTPTVNAVQPGAVGPSNE 864
                   P  GP  +V+    T              P  T+S P +      A     E
Sbjct: 543 TLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEE 602

Query: 865 LPGM-SGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPV 923
           L G  SG      A           D++    H A A S  P+ P +++ +     P P 
Sbjct: 603 LRGYDSGPEGGAAASPPP-------DAELAACHPA-AWSRGPAPPLAFRGAPGAPLPWPP 654

Query: 924 AYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKP 958
           A  P  +           P +A P+      G  P
Sbjct: 655 ATGPGSADGLCTIYETEGPESATPAPGALDPGPSP 689



 Score = 38.1 bits (87), Expect = 0.046
 Identities = 78/347 (22%), Positives = 122/347 (35%), Gaps = 56/347 (16%)

Query: 754  KTPPPVAPKPAVKSSSSQPVTPVS--PVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQP 811
            + P  + P+P        PVTP +   + + G    +P A         T+  S   A P
Sbjct: 20   RAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGP 79

Query: 812  SYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTP--TVNAVQPGAVGPSN---ELP 866
            +     PAS      P         ++N +P P VS+P       +PG +G         
Sbjct: 80   TRTSRPPASGRGERAP--------PAKNTSPGP-VSSPGRASGTTRPGPLGQKGLRISAE 130

Query: 867  GMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQS-PTPSLPA------SWKYSSNVRA 919
                RG    A ++S +           A A R  S PTP  P+      S    + V  
Sbjct: 131  ETVARGKATEAPKRSALS----------AGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 180

Query: 920  PPPVAYN----PIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNAS 975
            P P        P   P   +++  S+ S  +PS   +++   P     + +     L++S
Sbjct: 181  PRPAPSARPRPPTEGPRKSVSSA-SEHSTTEPSPAARRR---PSAGGGLQRPASRSLSSS 236

Query: 976  LFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPS 1035
                  P A+ G   + + +         A P +P     P  +QA      P  T P  
Sbjct: 237  ATPLSSP-ARSGPSARGTPRA-------PAHPSQP----KPKGLQA---LRPPQVTPPRK 281

Query: 1036 FFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSGVT 1082
              A A  P+S+SP+    P++P   SA  S    P P  +      T
Sbjct: 282  DAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATT 328



 Score = 37.4 bits (85), Expect = 0.078
 Identities = 79/337 (23%), Positives = 116/337 (34%), Gaps = 71/337 (21%)

Query: 574 SETANIQRMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAP---PPYSAVTPPPD 630
           S +A      P +  A P     + PA+P  P     +P    P P   PP     PPP 
Sbjct: 422 SPSATPPSQAPPSLAAPPLQVPPSPPASP--PMSPSATPPPQAPPPLAAPPLQLAKPPPQ 479

Query: 631 AFSRGVSSPI-AGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISV------------P 677
           A     + P+ A P+ P  +P  AP+S  A    S       +   V            P
Sbjct: 480 APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPP 539

Query: 678 AKRTGILQEAKRRSTTKPMFTFKEPKVS-------PNPELLSLLQNSEGK--RGTGAGGD 728
           A  T  LQ  +R  T  P  +   P+++       P P   S      G    G  +   
Sbjct: 540 ASPT--LQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT 597

Query: 729 SGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQ 788
           S PEE            ++   +  +     +P P  + ++  P       WS G AP  
Sbjct: 598 STPEE------------LRGYDSGPEGGAAASPPPDAELAACHPA-----AWSRGPAP-- 638

Query: 789 PPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVST 848
           P AF                  P  P   P +T    GP  G    + +   T  P  +T
Sbjct: 639 PLAFR---------------GAPGAPLPWPPAT----GP--GSADGLCTIYETEGPESAT 677

Query: 849 PTVNAVQPG-AVGPS-NELPGMSGRGAQLFAKRQSRM 883
           P   A+ PG + G S  +    +G GA   + +Q+R+
Sbjct: 678 PAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARL 714


>gi|150418009 transforming, acidic coiled-coil containing protein 2
            isoform a [Homo sapiens]
          Length = 2948

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 128/601 (21%), Positives = 212/601 (35%), Gaps = 109/601 (18%)

Query: 520  REQDAAQTDGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANI 579
            R  DA   +G   T   +RK  +SV     +SKS +  S  L    Q + F G S + N 
Sbjct: 2055 RASDAKNQEGKVNT---RRKSTDSV----PISKSTLSRSLSL----QASDFDGASSSGNP 2103

Query: 580  QRMV---------------PMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSA 624
            + +                 + RT KP P S+ +  T   PT   T P+ +    P   +
Sbjct: 2104 EAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTE--TPPVKETQQEPDEES 2161

Query: 625  VTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGIL 684
            + P  +  +    +  A    P P        +PA                V  K    L
Sbjct: 2162 LVPSGENLASETKTESAKTEGPSPALLEETPLEPA----------------VGPKAACPL 2205

Query: 685  QEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEA-- 742
                      P       + SP     +L   +  + G     DSG +ED  + G     
Sbjct: 2206 DSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRL 2265

Query: 743  -CNFMQSSSA---KQKTPPP---VAPKPAVKSSSSQPVTPVSP--VWSPGVAPTQPPAFP 793
              ++ +  S+   +Q+ PPP   +  KP  K    +P    +P  + +   +P + PA P
Sbjct: 2266 EFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEP 2325

Query: 794  TSNP-SKGTVVSSI-KIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTP--------- 842
               P +KGT    I K   P++ P    S +      + P+    S N+ P         
Sbjct: 2326 NDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQ-----ESPKLPQQSYNFDPDTCDESVDP 2380

Query: 843  -KPTVSTPTVNAVQPGAV---GPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAA 898
             K +  TP+  +  P +      + E  G+ G G    AK+    +K  + +DT +   +
Sbjct: 2381 FKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKK----KKTPLKTDTFRVKKS 2436

Query: 899  RAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQ-------------PSAA 945
              +SP    P+     +     PPV    +H+      A+ +Q                 
Sbjct: 2437 PKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYP 2496

Query: 946  QPSKM----GKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALA 1001
            QPS +     + K   P   LD       +    + +  P D  D  P+K ++ +    +
Sbjct: 2497 QPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQD--DDAPKKQALYLMFDTS 2554

Query: 1002 MKQALPPRPVN-AASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQE 1060
             +  +   PV  + SPT    SS     A  +        ++  +  PVP G+  +P QE
Sbjct: 2555 QESPVKSSPVRMSESPTPCSGSSFEETEALVN--------TAAKNQHPVPRGL--APNQE 2604

Query: 1061 S 1061
            S
Sbjct: 2605 S 2605



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 116/532 (21%), Positives = 170/532 (31%), Gaps = 97/532 (18%)

Query: 606  TRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQP---------PPWP------ 650
            T   T+P+   PAPPP     PPP+       S    P +P         P  P      
Sbjct: 1955 TPESTTPVKAPPAPPP-----PPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVE 2009

Query: 651  ----QPAPWSQPAFYDSSERIASRD------ERISVPAKRTGILQEAKRRSTTKPMFTFK 700
                +P   S  A +D  + IAS        + I +      +   A      +     +
Sbjct: 2010 GSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTR 2069

Query: 701  EPKVSPNPELLSLLQNSEGKRGT---GAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPP 757
                   P   S L  S   + +   GA     PE   L+  A +     +SS  ++T  
Sbjct: 2070 RKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKK 2129

Query: 758  PVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPT-SNPSKGTVVSSIKIAQPS---- 812
            P  P    K ++ +P T   PV      P +    P+  N +  T   S K   PS    
Sbjct: 2130 PRPPSLKKKQTTKKP-TETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALL 2188

Query: 813  -YPPARPASTLNVAGPFKGPQA---------AVASQNYTPKPTVSTPTVNAVQPGAVGPS 862
               P  PA     A P     A             QN  P    + P   A + G V PS
Sbjct: 2189 EETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPS 2248

Query: 863  NELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPP 922
            +     SG      AK  S   ++    D   +   + ++P P+     K         P
Sbjct: 2249 D-----SGGQEDSPAKGLSVRLEFDYSEDK-SSWDNQQENPPPTKKIGKK---------P 2293

Query: 923  VAYNPIHSPSYPLAALK------SQP-SAAQPSKMGKKKGK-------------KPLNAL 962
            VA  P+  P       K      S P S A+P+ +   KG               P ++ 
Sbjct: 2294 VAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSST 2353

Query: 963  DVMKHQPYQLNASLFTFQPPDAKDGL-PQKSSVKVNSALAMKQALPPRPVNAASPTNVQA 1021
              M+  P +L    + F P    + + P K+S K  S+ +   A    P +A     V  
Sbjct: 2354 SKMQESP-KLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDG 2412

Query: 1022 SSVYSVPAYTSPP----SFFAE-------ASSPVSASPVPVGIPTSPKQESA 1062
              +         P    +F  +        S P S  P P   P +P   SA
Sbjct: 2413 DGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISA 2464



 Score = 34.7 bits (78), Expect = 0.51
 Identities = 85/368 (23%), Positives = 126/368 (34%), Gaps = 69/368 (18%)

Query: 617 PAPPPYS-----------AVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQ-------P 658
           P+PPP             A  PP    +   ++P  GP    P  +PAP +        P
Sbjct: 96  PSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFP 155

Query: 659 AFYDSSERIASRDERISVPA--KRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQN 716
           A  DSS       E  +VP+  +     +E ++ S +      + P +SP P L   ++ 
Sbjct: 156 AERDSS---TPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVP-LREPMKA 211

Query: 717 SEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPV 776
                G   GG    E++    G       Q  ++ Q TP   AP  A + + S  V   
Sbjct: 212 PLCGEGDQPGGFESQEKEAAG-GFPPAESRQGVASVQVTPE--APAAAQQGTESSAVLEK 268

Query: 777 SPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVA 836
           SP+  P     Q PA   S+  +G         Q   PP      L        P+   +
Sbjct: 269 SPL-KPMAPIPQDPAPRASDRERG---------QGEAPPQYLTDDLEFLRACHLPR---S 315

Query: 837 SQNYTPKPTVSTPTVNAVQP--GAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQ 894
           +    P+  V+  +  + Q   GA  P  ELP   G  +           K  +D+  VQ
Sbjct: 316 NSGAAPEAEVNAASQESCQQPVGAYLPHAELPW--GLPSPALVPEAGGSGKEALDTIDVQ 373

Query: 895 AH---------------AARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALK 939
            H                A    P   LP S         P P    P    ++P ++L 
Sbjct: 374 GHPQTGMRGTKPNQVVCVAAGGQPEGGLPVS---------PEPSLLTPTEE-AHPASSLA 423

Query: 940 SQPSAAQP 947
           S P+A  P
Sbjct: 424 SFPAAQIP 431


>gi|45827755 transforming, acidic coiled-coil containing protein 2
            isoform b [Homo sapiens]
          Length = 1094

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 128/601 (21%), Positives = 212/601 (35%), Gaps = 109/601 (18%)

Query: 520  REQDAAQTDGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANI 579
            R  DA   +G   T   +RK  +SV     +SKS +  S  L    Q + F G S + N 
Sbjct: 201  RASDAKNQEGKVNT---RRKSTDSV----PISKSTLSRSLSL----QASDFDGASSSGNP 249

Query: 580  QRMV---------------PMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSA 624
            + +                 + RT KP P S+ +  T   PT   T P+ +    P   +
Sbjct: 250  EAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTE--TPPVKETQQEPDEES 307

Query: 625  VTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGIL 684
            + P  +  +    +  A    P P        +PA                V  K    L
Sbjct: 308  LVPSGENLASETKTESAKTEGPSPALLEETPLEPA----------------VGPKAACPL 351

Query: 685  QEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEA-- 742
                      P       + SP     +L   +  + G     DSG +ED  + G     
Sbjct: 352  DSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRL 411

Query: 743  -CNFMQSSSA---KQKTPPP---VAPKPAVKSSSSQPVTPVSP--VWSPGVAPTQPPAFP 793
              ++ +  S+   +Q+ PPP   +  KP  K    +P    +P  + +   +P + PA P
Sbjct: 412  EFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEP 471

Query: 794  TSNP-SKGTVVSSI-KIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTP--------- 842
               P +KGT    I K   P++ P    S +      + P+    S N+ P         
Sbjct: 472  NDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQ-----ESPKLPQQSYNFDPDTCDESVDP 526

Query: 843  -KPTVSTPTVNAVQPGAV---GPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAA 898
             K +  TP+  +  P +      + E  G+ G G    AK+    +K  + +DT +   +
Sbjct: 527  FKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKK----KKTPLKTDTFRVKKS 582

Query: 899  RAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQ-------------PSAA 945
              +SP    P+     +     PPV    +H+      A+ +Q                 
Sbjct: 583  PKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYP 642

Query: 946  QPSKM----GKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALA 1001
            QPS +     + K   P   LD       +    + +  P D  D  P+K ++ +    +
Sbjct: 643  QPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQD--DDAPKKQALYLMFDTS 700

Query: 1002 MKQALPPRPVN-AASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQE 1060
             +  +   PV  + SPT    SS     A  +        ++  +  PVP G+  +P QE
Sbjct: 701  QESPVKSSPVRMSESPTPCSGSSFEETEALVN--------TAAKNQHPVPRGL--APNQE 750

Query: 1061 S 1061
            S
Sbjct: 751  S 751



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 116/532 (21%), Positives = 170/532 (31%), Gaps = 97/532 (18%)

Query: 606  TRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQP---------PPWP------ 650
            T   T+P+   PAPPP     PPP+       S    P +P         P  P      
Sbjct: 101  TPESTTPVKAPPAPPP-----PPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVE 155

Query: 651  ----QPAPWSQPAFYDSSERIASRD------ERISVPAKRTGILQEAKRRSTTKPMFTFK 700
                +P   S  A +D  + IAS        + I +      +   A      +     +
Sbjct: 156  GSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTR 215

Query: 701  EPKVSPNPELLSLLQNSEGKRGT---GAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPP 757
                   P   S L  S   + +   GA     PE   L+  A +     +SS  ++T  
Sbjct: 216  RKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKK 275

Query: 758  PVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPT-SNPSKGTVVSSIKIAQPS---- 812
            P  P    K ++ +P T   PV      P +    P+  N +  T   S K   PS    
Sbjct: 276  PRPPSLKKKQTTKKP-TETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALL 334

Query: 813  -YPPARPASTLNVAGPFKGPQA---------AVASQNYTPKPTVSTPTVNAVQPGAVGPS 862
               P  PA     A P     A             QN  P    + P   A + G V PS
Sbjct: 335  EETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPS 394

Query: 863  NELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPP 922
            +     SG      AK  S   ++    D   +   + ++P P+     K         P
Sbjct: 395  D-----SGGQEDSPAKGLSVRLEFDYSEDK-SSWDNQQENPPPTKKIGKK---------P 439

Query: 923  VAYNPIHSPSYPLAALK------SQP-SAAQPSKMGKKKGK-------------KPLNAL 962
            VA  P+  P       K      S P S A+P+ +   KG               P ++ 
Sbjct: 440  VAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSST 499

Query: 963  DVMKHQPYQLNASLFTFQPPDAKDGL-PQKSSVKVNSALAMKQALPPRPVNAASPTNVQA 1021
              M+  P +L    + F P    + + P K+S K  S+ +   A    P +A     V  
Sbjct: 500  SKMQESP-KLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDG 558

Query: 1022 SSVYSVPAYTSPP----SFFAE-------ASSPVSASPVPVGIPTSPKQESA 1062
              +         P    +F  +        S P S  P P   P +P   SA
Sbjct: 559  DGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISA 610


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,375,708
Number of Sequences: 37866
Number of extensions: 2929645
Number of successful extensions: 23255
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 1109
Number of HSP's that attempted gapping in prelim test: 14559
Number of HSP's gapped (non-prelim): 6766
length of query: 1093
length of database: 18,247,518
effective HSP length: 113
effective length of query: 980
effective length of database: 13,968,660
effective search space: 13689286800
effective search space used: 13689286800
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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