Search of human proteins with 169234807

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
         (991 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]          2015   0.0  
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]          1928   0.0  
gi|153085395 histone deacetylase 4 [Homo sapiens]                     842   0.0  
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]            721   0.0  
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]            721   0.0  
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]            674   0.0  
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]            674   0.0  
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]            650   0.0  
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]            438   e-122
gi|13128864 histone deacetylase 6 [Homo sapiens]                      285   1e-76
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]           232   1e-60
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]          197   3e-50
gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]             115   3e-25
gi|13128860 histone deacetylase 1 [Homo sapiens]                      108   2e-23
gi|116284376 histone deacetylase 2 [Homo sapiens]                     104   4e-22
gi|8923769 histone deacetylase 8 [Homo sapiens]                        94   6e-19
gi|13128862 histone deacetylase 3 [Homo sapiens]                       86   2e-16
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    64   7e-10
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]           59   3e-08
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    58   4e-08
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]           57   9e-08
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   57   9e-08
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   57   9e-08
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   57   9e-08
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    57   9e-08
gi|41281612 zinc finger protein 828 [Homo sapiens]                     54   6e-07
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom...    54   7e-07
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom...    54   7e-07
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap...    54   7e-07
gi|148833504 interleukin 16 isoform 2 [Homo sapiens]                   50   8e-06

>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
          Length = 991

 Score = 2015 bits (5221), Expect = 0.0
 Identities = 991/991 (100%), Positives = 991/991 (100%)

Query: 1   MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA 60
           MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA
Sbjct: 1   MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA 60

Query: 61  LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120
           LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA
Sbjct: 61  LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120

Query: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP 180
           SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP
Sbjct: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP 180

Query: 181 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS 240
           SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS
Sbjct: 181 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS 240

Query: 241 SSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAP 300
           SSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAP
Sbjct: 241 SSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAP 300

Query: 301 ARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL 360
           ARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL
Sbjct: 301 ARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL 360

Query: 361 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL 420
           LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL
Sbjct: 361 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL 420

Query: 421 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP 480
           KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP
Sbjct: 421 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP 480

Query: 481 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS 540
           LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS
Sbjct: 481 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS 540

Query: 541 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR 600
           QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR
Sbjct: 541 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR 600

Query: 601 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV 660
           SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV
Sbjct: 601 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV 660

Query: 661 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF 720
           GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF
Sbjct: 661 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF 720

Query: 721 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS 780
           FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS
Sbjct: 721 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS 780

Query: 781 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD 840
           GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD
Sbjct: 781 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD 840

Query: 841 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG 900
           AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG
Sbjct: 841 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG 900

Query: 901 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE 960
           NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE
Sbjct: 901 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE 960

Query: 961 AVTALASLSVGILAEDRPSEQLVEEEEPMNL 991
           AVTALASLSVGILAEDRPSEQLVEEEEPMNL
Sbjct: 961 AVTALASLSVGILAEDRPSEQLVEEEEPMNL 991


>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
          Length = 954

 Score = 1928 bits (4995), Expect = 0.0
 Identities = 954/991 (96%), Positives = 954/991 (96%), Gaps = 37/991 (3%)

Query: 1   MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA 60
           MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA
Sbjct: 1   MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA 60

Query: 61  LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120
           LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA
Sbjct: 61  LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120

Query: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP 180
           SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP
Sbjct: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP 180

Query: 181 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS 240
           SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS
Sbjct: 181 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS 240

Query: 241 SSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAP 300
           SSTPASGCSSPNDSEHGPNPILGSE                                   
Sbjct: 241 SSTPASGCSSPNDSEHGPNPILGSE----------------------------------- 265

Query: 301 ARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL 360
             ADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL
Sbjct: 266 --ADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL 323

Query: 361 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL 420
           LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL
Sbjct: 324 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL 383

Query: 421 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP 480
           KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP
Sbjct: 384 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP 443

Query: 481 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS 540
           LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS
Sbjct: 444 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS 503

Query: 541 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR 600
           QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR
Sbjct: 504 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR 563

Query: 601 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV 660
           SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV
Sbjct: 564 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV 623

Query: 661 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF 720
           GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF
Sbjct: 624 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF 683

Query: 721 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS 780
           FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS
Sbjct: 684 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS 743

Query: 781 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD 840
           GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD
Sbjct: 744 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD 803

Query: 841 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG 900
           AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG
Sbjct: 804 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG 863

Query: 901 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE 960
           NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE
Sbjct: 864 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE 923

Query: 961 AVTALASLSVGILAEDRPSEQLVEEEEPMNL 991
           AVTALASLSVGILAEDRPSEQLVEEEEPMNL
Sbjct: 924 AVTALASLSVGILAEDRPSEQLVEEEEPMNL 954


>gi|153085395 histone deacetylase 4 [Homo sapiens]
          Length = 1084

 Score =  842 bits (2175), Expect = 0.0
 Identities = 505/1006 (50%), Positives = 636/1006 (63%), Gaps = 96/1006 (9%)

Query: 59   LALQRPQRLHHHL-----FLAGLQQQRSVEPMR-LSMDTPMPELQVGPQEQELRQLLHKD 112
            L+ Q   +LH H+      LA   QQ  +E  R L       EL+   +EQ+L+QL +K+
Sbjct: 100  LSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKE 159

Query: 113  KSKRSAVASSVVKQKLAEVILKKQQAALERTVH---PNSPGIPYRTLE--PLETEGATRS 167
            K K SAVAS+ VK KL E +L K++A   R ++    + P   Y   +   L+     +S
Sbjct: 160  KGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQS 219

Query: 168  MLS-SFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKESAP--P 223
             +S S+  PV  +  D  + FPLRKT SEPNLKLR + K+ + ERR +PLLR++  P   
Sbjct: 220  GVSTSYNHPVLGM-YDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVT 278

Query: 224  SLRRRPAETLGDSSPSSSSTPASGCSSPNDS------EHGPNPILGS---EALLGQRLRL 274
            +L++RP +    +  + SS P SG SSPN+S      E+G  P + S   E  L  RL  
Sbjct: 279  ALKKRPLDV---TDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVA 335

Query: 275  QETSVAPFALPTVSLLPAITLGLPAPA-------RADSDRRTHPTLGPRGPILGSPH-TP 326
            +E S AP  L T   LP ITLGLPA         + D++R T P L  R  +    H TP
Sbjct: 336  REGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTP 395

Query: 327  LFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGS 386
                  LE + G      LQ ++LL+   + APL+T  GLG LP H AQSL+  +R+S S
Sbjct: 396  YLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVT--GLGALPLH-AQSLVGADRVSPS 452

Query: 387  ----GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQ-----------VIKRSA 431
                  H PL RT+S PLP +A A       Q   + L+ H Q           +I + +
Sbjct: 453  IHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPS 512

Query: 432  KPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQP--------------EARG 477
            +P+ +P      + E+L        +   D L  ++  H Q               EA  
Sbjct: 513  EPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEP 572

Query: 478  PA---PLQQHP---------QVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQS 525
            P    P Q+ P         Q LL EQQR+       ++ +   +P++ GGHRPLSRAQS
Sbjct: 573  PREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQS 632

Query: 526  SPA-APASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHA 584
            SPA A   +S  EP ++ R             FTTGL+YD++MLKHQC+CG +S HPEHA
Sbjct: 633  SPASATFPVSVQEPPTKPR-------------FTTGLVYDTLMLKHQCTCGSSSSHPEHA 679

Query: 585  GRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLA 644
            GRIQSIWSRLQE GLR +CEC+RGRKA+LEELQ+VHSE H LLYGTNPL+R KLD+ KL 
Sbjct: 680  GRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLL 739

Query: 645  GLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVR 704
            G LA  +FV LPCGGVGVD+DTIWNE+HS+ AAR A G V +L FKVA+ ELKNGFAVVR
Sbjct: 740  GSLAS-VFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVR 798

Query: 705  PPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVL 764
            PPGHHA+ ST MGFC+FNSVA+A + LQQ+   SKILIVDWDVHHGNGTQQ FY DPSVL
Sbjct: 799  PPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVL 858

Query: 765  YISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPI 824
            Y+SLHR+DDGNFFPGSGA DEVG G G GFNVN+A+ GGLDPPMGD EYLAAFR VVMPI
Sbjct: 859  YMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPI 918

Query: 825  AREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDL 884
            A EF+PD+VLVS+GFDA EGHP PLGGY++SA+CFGY+T+QLM LAGG +VLALEGGHDL
Sbjct: 919  ASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDL 978

Query: 885  TAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCP 944
            TAICDASEACV+ALLGN +DPL E+  +Q+PN NA+RS+E V+ +HSKYW C+QR  S  
Sbjct: 979  TAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTA 1038

Query: 945  DSWVPRVPGADKEEVEAVTALASLSVGIL-AEDRPSEQLVEEEEPM 989
               +      + EE E VTA+ASLSVG+  AE RP E+ +EEE P+
Sbjct: 1039 GRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL 1084


>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
          Length = 1123

 Score =  721 bits (1860), Expect = 0.0
 Identities = 462/1092 (42%), Positives = 607/1092 (55%), Gaps = 162/1092 (14%)

Query: 34   GPQPQPMDLR---VGQRPPV--EPPPEPTLLALQRPQRL------------HHHL----- 71
            G  P P++LR   VG   P   E   +  LLAL++ Q+L            H HL     
Sbjct: 52   GGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHE 111

Query: 72   ------------FLAGLQQQ--------RSVEPMRLSMDTPMPELQVGPQEQELRQLLHK 111
                         LA  QQQ        + +E  R        EL+    EQ+L  L +K
Sbjct: 112  VQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNK 171

Query: 112  DKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSS 171
            +KSK SA+AS+ VK +L E +L K +        P   G+ +   +  +  GA  + L  
Sbjct: 172  EKSKESAIASTEVKLRLQEFLLSKSK-------EPTPGGLNHSLPQHPKCWGAHHASLDQ 224

Query: 172  FLPPVPSLPSDPPEH-------------FPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLR 217
              PP    P  PP +             FPLRKT SEPNLK+R + K+ + ERR +PLLR
Sbjct: 225  SSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLR 284

Query: 218  KESAP--PSLRRRPAETLGDSSPSSS---STPASGCSSPNDSEH--------GPNPILGS 264
            ++      + ++R  E  G    +SS   S P SG SSPN S          G  P + +
Sbjct: 285  RKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPT 344

Query: 265  EALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPA---------------RADSDRRT 309
            E L   R    ++S   F+L T   LP I+LGL A                 + +++R+ 
Sbjct: 345  EMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQA 404

Query: 310  HPTLGPRGPILGSPHTPLFLPH---GLEPEAGGTL---PSRLQPILLLDPSGSHAPLLTV 363
              +L   G + G   +   +P    G+  E  G+     S LQ +LLL+ +   + L+ V
Sbjct: 405  LQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAV 464

Query: 364  PGLGPLPFHFAQSLMTTERLSGS-GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLE---- 418
            P  G  P    + + T+ R  G    H PLSRT+S PLP S  A       Q   +    
Sbjct: 465  PLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEK 524

Query: 419  QLKTHVQVIKRSAKPSEKPRLRQIPSAEDLET------------------DGGGPGQVVD 460
            Q +  +Q+ K   K  E PR       E  E                   +G    +   
Sbjct: 525  QKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQ 584

Query: 461  DGLEHR-ELGHGQPEA--------RGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVL-- 509
            + LE   E   G+ E          G +  ++ P +    ++  AG     S    +   
Sbjct: 585  EDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDL----EEPGAGYKKLFSDAQPLQPL 640

Query: 510  ------LPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIY 563
                  L LA   H+ L R QSSPAAP  + +P            + P + L FTTG++Y
Sbjct: 641  QVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPP-----------DQPVKHL-FTTGVVY 688

Query: 564  DSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSER 623
            D+ MLKHQC CG+   HPEHAGRIQSIWSRLQE GL S+CE +RGRKA+L+E+Q+VHSE 
Sbjct: 689  DTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEY 748

Query: 624  HVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGS 683
            H LLYGT+PL+R KLD+ KL G ++Q+M+ +LPCGG+GVD+DT+WNE+HSS+A R A G 
Sbjct: 749  HTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGC 808

Query: 684  VTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIV 743
            + +LAFKVA+ ELKNGFA++RPPGHHA+ STAMGFCFFNSVAI  + LQQ+    K+LIV
Sbjct: 809  LLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIV 868

Query: 744  DWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGG 803
            DWD+HHGNGTQQ FY DPSVLYISLHR+D+GNFFPGSGA +EVG G G G+NVNVAW GG
Sbjct: 869  DWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGG 928

Query: 804  LDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMT 863
            +DPP+GD EYL AFR VVMPIA EFSPD+VLVSAGFDA EGH +PLGGY V+A+CFG++T
Sbjct: 929  VDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLT 988

Query: 864  QQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSL 923
            +QLM LAGG VVLALEGGHDLTAICDASEACV+ALL   + PL E   +QKPN+NA+ +L
Sbjct: 989  RQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATL 1048

Query: 924  EAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILA--------- 974
            E VI + SK+W C+Q+ A+     +      + EE E V+A+A LSVG            
Sbjct: 1049 EKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREH 1108

Query: 975  EDRPSEQLVEEE 986
              RP+E+ +E+E
Sbjct: 1109 SPRPAEEPMEQE 1120


>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
          Length = 1122

 Score =  721 bits (1860), Expect = 0.0
 Identities = 462/1092 (42%), Positives = 607/1092 (55%), Gaps = 162/1092 (14%)

Query: 34   GPQPQPMDLR---VGQRPPV--EPPPEPTLLALQRPQRL------------HHHL----- 71
            G  P P++LR   VG   P   E   +  LLAL++ Q+L            H HL     
Sbjct: 51   GGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHE 110

Query: 72   ------------FLAGLQQQ--------RSVEPMRLSMDTPMPELQVGPQEQELRQLLHK 111
                         LA  QQQ        + +E  R        EL+    EQ+L  L +K
Sbjct: 111  VQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNK 170

Query: 112  DKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSS 171
            +KSK SA+AS+ VK +L E +L K +        P   G+ +   +  +  GA  + L  
Sbjct: 171  EKSKESAIASTEVKLRLQEFLLSKSK-------EPTPGGLNHSLPQHPKCWGAHHASLDQ 223

Query: 172  FLPPVPSLPSDPPEH-------------FPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLR 217
              PP    P  PP +             FPLRKT SEPNLK+R + K+ + ERR +PLLR
Sbjct: 224  SSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLR 283

Query: 218  KESAP--PSLRRRPAETLGDSSPSSS---STPASGCSSPNDSEH--------GPNPILGS 264
            ++      + ++R  E  G    +SS   S P SG SSPN S          G  P + +
Sbjct: 284  RKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPT 343

Query: 265  EALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPA---------------RADSDRRT 309
            E L   R    ++S   F+L T   LP I+LGL A                 + +++R+ 
Sbjct: 344  EMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQA 403

Query: 310  HPTLGPRGPILGSPHTPLFLPH---GLEPEAGGTL---PSRLQPILLLDPSGSHAPLLTV 363
              +L   G + G   +   +P    G+  E  G+     S LQ +LLL+ +   + L+ V
Sbjct: 404  LQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAV 463

Query: 364  PGLGPLPFHFAQSLMTTERLSGS-GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLE---- 418
            P  G  P    + + T+ R  G    H PLSRT+S PLP S  A       Q   +    
Sbjct: 464  PLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEK 523

Query: 419  QLKTHVQVIKRSAKPSEKPRLRQIPSAEDLET------------------DGGGPGQVVD 460
            Q +  +Q+ K   K  E PR       E  E                   +G    +   
Sbjct: 524  QKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQ 583

Query: 461  DGLEHR-ELGHGQPEA--------RGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVL-- 509
            + LE   E   G+ E          G +  ++ P +    ++  AG     S    +   
Sbjct: 584  EDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDL----EEPGAGYKKLFSDAQPLQPL 639

Query: 510  ------LPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIY 563
                  L LA   H+ L R QSSPAAP  + +P            + P + L FTTG++Y
Sbjct: 640  QVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPP-----------DQPVKHL-FTTGVVY 687

Query: 564  DSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSER 623
            D+ MLKHQC CG+   HPEHAGRIQSIWSRLQE GL S+CE +RGRKA+L+E+Q+VHSE 
Sbjct: 688  DTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEY 747

Query: 624  HVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGS 683
            H LLYGT+PL+R KLD+ KL G ++Q+M+ +LPCGG+GVD+DT+WNE+HSS+A R A G 
Sbjct: 748  HTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGC 807

Query: 684  VTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIV 743
            + +LAFKVA+ ELKNGFA++RPPGHHA+ STAMGFCFFNSVAI  + LQQ+    K+LIV
Sbjct: 808  LLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIV 867

Query: 744  DWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGG 803
            DWD+HHGNGTQQ FY DPSVLYISLHR+D+GNFFPGSGA +EVG G G G+NVNVAW GG
Sbjct: 868  DWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGG 927

Query: 804  LDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMT 863
            +DPP+GD EYL AFR VVMPIA EFSPD+VLVSAGFDA EGH +PLGGY V+A+CFG++T
Sbjct: 928  VDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLT 987

Query: 864  QQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSL 923
            +QLM LAGG VVLALEGGHDLTAICDASEACV+ALL   + PL E   +QKPN+NA+ +L
Sbjct: 988  RQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATL 1047

Query: 924  EAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILA--------- 974
            E VI + SK+W C+Q+ A+     +      + EE E V+A+A LSVG            
Sbjct: 1048 EKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREH 1107

Query: 975  EDRPSEQLVEEE 986
              RP+E+ +E+E
Sbjct: 1108 SPRPAEEPMEQE 1119


>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
          Length = 1066

 Score =  674 bits (1739), Expect = 0.0
 Identities = 454/1023 (44%), Positives = 572/1023 (55%), Gaps = 126/1023 (12%)

Query: 59   LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115
            L  Q   +L  H+   LA  QQQ  +E   +L       E++   +EQ+L  L  KD+ +
Sbjct: 75   LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134

Query: 116  RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175
              AVAS+ VKQKL E +L K      +    N           L    A  + L    PP
Sbjct: 135  ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191

Query: 176  VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222
            +         +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +  
Sbjct: 192  LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251

Query: 223  PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEALLGQR 271
             S ++R  E     S  SSS+P SG SSPN+   G           P P    + +  QR
Sbjct: 252  TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPH-AEQMVSQQR 308

Query: 272  LRLQETSVAPFALPTVSLLPAITLGLPA-PARADSDRRTHPTLGPRGPIL--GSPHTPLF 328
            + + E S+   +L T   LP ITLGLPA P++ ++              L  G P     
Sbjct: 309  ILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVP----- 363

Query: 329  LPHGLEPEAGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFH 372
                L  + GG++P S   P + L+   P+ SH  LL    L            G +P H
Sbjct: 364  ----LPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLH 419

Query: 373  FAQSLMTTERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHV 424
                L T ER+S           H PL+RT+S PLP S  A        Q  LE+ K + 
Sbjct: 420  PQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQ 479

Query: 425  Q------VIKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGL 463
            Q      ++ +S +  ++P      + E+L+ D                      VDD L
Sbjct: 480  QQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTL 539

Query: 464  EH------RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG 516
                    +E      E      ++   Q    +Q  L     R  S     L  +   G
Sbjct: 540  GQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDG 599

Query: 517  ---HRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCS 573
               HR +SR  SSPAA      P PA    +   S          TG+ YD +MLKHQC 
Sbjct: 600  LEKHRLVSRTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCV 647

Query: 574  CGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPL 633
            CG+++ HPEHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL
Sbjct: 648  CGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPL 707

Query: 634  SRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVAS 693
               KLD   L G  +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS
Sbjct: 708  DGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVAS 767

Query: 694  RELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGT 753
             ELKNGFAVVRPPGHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGT
Sbjct: 768  GELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGT 827

Query: 754  QQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEY 813
            QQ FY DPS+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EY
Sbjct: 828  QQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEY 887

Query: 814  LAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGA 873
            L AFR +V P+A+EF PD+VLVSAGFDA EGH  PLGGY V+AKCFG++T+QLM LA G 
Sbjct: 888  LEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGR 947

Query: 874  VVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKY 933
            VVLALEGGHDLTAICDASEACV ALLGN ++PL+E+   Q PN+NA+ SL+ +I + SKY
Sbjct: 948  VVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKY 1007

Query: 934  WGCMQRLASCPDSWVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEE 985
            W  ++ +A      VPR   + GA  +EE E V+ALASL+V +      ED  +     E
Sbjct: 1008 WKSVRMVA------VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPME 1061

Query: 986  EEP 988
            EEP
Sbjct: 1062 EEP 1064


>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
          Length = 1069

 Score =  674 bits (1738), Expect = 0.0
 Identities = 450/1018 (44%), Positives = 568/1018 (55%), Gaps = 123/1018 (12%)

Query: 61   LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120
            LQ   +L   L     QQ+   +  +L       E++   +EQ+L  L  KD+ +  AVA
Sbjct: 83   LQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVA 142

Query: 121  SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVP--- 177
            S+ VKQKL E +L K      +    N           L    A  + L    PP+    
Sbjct: 143  STEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTS 199

Query: 178  -----SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAPPSLRR 227
                 +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +   S ++
Sbjct: 200  PSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKK 259

Query: 228  RPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEALLGQRLRLQE 276
            R  E     S  SSS+P SG SSPN+   G           P P    + +  QR+ + E
Sbjct: 260  RMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPH-AEQMVSQQRILIHE 316

Query: 277  TSVAPFALPTVSLLPAITLGLPA-PARADSDRRTHPTLGPRGPIL--GSPHTPLFLPHGL 333
             S+   +L T   LP ITLGLPA P++ ++              L  G P         L
Sbjct: 317  DSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVP---------L 367

Query: 334  EPEAGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSL 377
              + GG++P S   P + L+   P+ SH  LL    L            G +P H    L
Sbjct: 368  PGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPL 427

Query: 378  MTTERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ---- 425
             T ER+S           H PL+RT+S PLP S  A        Q  LE+ K + Q    
Sbjct: 428  ATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHM 487

Query: 426  --VIKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH--- 465
              ++ +S +  ++P      + E+L+ D                      VDD L     
Sbjct: 488  NKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGA 547

Query: 466  ---RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HR 518
               +E      E      ++   Q    +Q  L     R  S     L  +   G   HR
Sbjct: 548  VKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHR 607

Query: 519  PLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNS 578
             +SR  SSPAA      P PA    +   S          TG+ YD +MLKHQC CG+++
Sbjct: 608  LVSRTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNST 655

Query: 579  RHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKL 638
             HPEHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL   KL
Sbjct: 656  THPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKL 715

Query: 639  DNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKN 698
            D   L G  +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKN
Sbjct: 716  DPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKN 775

Query: 699  GFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFY 758
            GFAVVRPPGHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGTQQ FY
Sbjct: 776  GFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFY 835

Query: 759  QDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFR 818
             DPS+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR
Sbjct: 836  ADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFR 895

Query: 819  IVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLAL 878
             +V P+A+EF PD+VLVSAGFDA EGH  PLGGY V+AKCFG++T+QLM LA G VVLAL
Sbjct: 896  TIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLAL 955

Query: 879  EGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQ 938
            EGGHDLTAICDASEACV ALLGN ++PL+E+   Q PN+NA+ SL+ +I + SKYW  ++
Sbjct: 956  EGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVR 1015

Query: 939  RLASCPDSWVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEEEEP 988
             +A      VPR   + GA  +EE E V+ALASL+V +      ED  +     EEEP
Sbjct: 1016 MVA------VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEP 1067


>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
          Length = 1011

 Score =  650 bits (1678), Expect = 0.0
 Identities = 429/958 (44%), Positives = 538/958 (56%), Gaps = 112/958 (11%)

Query: 59   LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115
            L  Q   +L  H+   LA  QQQ  +E   +L       E++   +EQ+L  L  KD+ +
Sbjct: 75   LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134

Query: 116  RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175
              AVAS+ VKQKL E +L K      +    N           L    A  + L    PP
Sbjct: 135  ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191

Query: 176  VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222
            +         +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +  
Sbjct: 192  LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251

Query: 223  PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEALLGQR 271
             S ++R  E     S  SSS+P SG SSPN+   G           P P    + +  QR
Sbjct: 252  TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPH-AEQMVSQQR 308

Query: 272  LRLQETSVAPFALPTVSLLPAITLGLPA-PARADSDRRTHPTLGPRGPIL--GSPHTPLF 328
            + + E S+   +L T   LP ITLGLPA P++ ++              L  G P     
Sbjct: 309  ILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVP----- 363

Query: 329  LPHGLEPEAGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFH 372
                L  + GG++P S   P + L+   P+ SH  LL    L            G +P H
Sbjct: 364  ----LPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLH 419

Query: 373  FAQSLMTTERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHV 424
                L T ER+S           H PL+RT+S PLP S  A        Q  LE+ K + 
Sbjct: 420  PQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQ 479

Query: 425  Q------VIKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGL 463
            Q      ++ +S +  ++P      + E+L+ D                      VDD L
Sbjct: 480  QQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTL 539

Query: 464  EH------RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG 516
                    +E      E      ++   Q    +Q  L     R  S     L  +   G
Sbjct: 540  GQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDG 599

Query: 517  ---HRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCS 573
               HR +SR  SSPAA      P PA    +   S          TG+ YD +MLKHQC 
Sbjct: 600  LEKHRLVSRTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCV 647

Query: 574  CGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPL 633
            CG+++ HPEHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL
Sbjct: 648  CGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPL 707

Query: 634  SRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVAS 693
               KLD   L G  +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS
Sbjct: 708  DGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVAS 767

Query: 694  RELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGT 753
             ELKNGFAVVRPPGHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGT
Sbjct: 768  GELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGT 827

Query: 754  QQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEY 813
            QQ FY DPS+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EY
Sbjct: 828  QQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEY 887

Query: 814  LAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGA 873
            L AFR +V P+A+EF PD+VLVSAGFDA EGH  PLGGY V+AKCFG++T+QLM LA G 
Sbjct: 888  LEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGR 947

Query: 874  VVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHS 931
            VVLALEGGHDLTAICDASEACV ALLGN ++PL+E+   Q PN+NA+ SL+ +I + S
Sbjct: 948  VVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1005


>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
          Length = 879

 Score =  438 bits (1126), Expect = e-122
 Identities = 329/813 (40%), Positives = 418/813 (51%), Gaps = 112/813 (13%)

Query: 59  LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115
           L  Q   +L  H+   LA  QQQ  +E   +L       E++   +EQ+L  L  KD+ +
Sbjct: 75  LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134

Query: 116 RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175
             AVAS+ VKQKL E +L K      +    N           L    A  + L    PP
Sbjct: 135 ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191

Query: 176 VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222
           +         +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +  
Sbjct: 192 LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251

Query: 223 PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEALLGQR 271
            S ++R  E     S  SSS+P SG SSPN+   G           P P    + +  QR
Sbjct: 252 TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPH-AEQMVSQQR 308

Query: 272 LRLQETSVAPFALPTVSLLPAITLGLPA-PARADSDRRTHPTLGPRGPIL--GSPHTPLF 328
           + + E S+   +L T   LP ITLGLPA P++ ++              L  G P     
Sbjct: 309 ILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVP----- 363

Query: 329 LPHGLEPEAGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFH 372
               L  + GG++P S   P + L+   P+ SH  LL    L            G +P H
Sbjct: 364 ----LPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLH 419

Query: 373 FAQSLMTTERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHV 424
               L T ER+S           H PL+RT+S PLP S  A        Q  LE+ K + 
Sbjct: 420 PQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQ 479

Query: 425 Q------VIKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGL 463
           Q      ++ +S +  ++P      + E+L+ D                      VDD L
Sbjct: 480 QQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTL 539

Query: 464 EH------RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG 516
                   +E      E      ++   Q    +Q  L     R  S     L  +   G
Sbjct: 540 GQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDG 599

Query: 517 ---HRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCS 573
              HR +SR  SSPAA      P PA    +   S          TG+ YD +MLKHQC 
Sbjct: 600 LEKHRLVSRTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCV 647

Query: 574 CGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPL 633
           CG+++ HPEHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL
Sbjct: 648 CGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPL 707

Query: 634 SRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVAS 693
              KLD   L G  +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS
Sbjct: 708 DGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVAS 767

Query: 694 RELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGT 753
            ELKNGFAVVRPPGHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGT
Sbjct: 768 GELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGT 827

Query: 754 QQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEV 786
           QQ FY DPS+LYISLHR+D+GNFFPGSGA +EV
Sbjct: 828 QQAFYADPSILYISLHRYDEGNFFPGSGAPNEV 860


>gi|13128864 histone deacetylase 6 [Homo sapiens]
          Length = 1215

 Score =  285 bits (730), Expect = 1e-76
 Identities = 174/380 (45%), Positives = 222/380 (58%), Gaps = 33/380 (8%)

Query: 559 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 618
           TGL+YD  M+ H C+  D S HPE   RI  I  RL+E GL  +C  L  R A+  EL +
Sbjct: 481 TGLVYDQNMMNH-CNLWD-SHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLT 538

Query: 619 VHSERHV-LLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAA 677
            HS  +V  L  T  +   +L                        + D+I+    +   A
Sbjct: 539 CHSAEYVGHLRATEKMKTRELHRESS-------------------NFDSIYICPSTFACA 579

Query: 678 RWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQS-K 736
           + A G+   L   V S E+ NG AVVRPPGHHA+   A GFCFFNSVA+A R  Q  S  
Sbjct: 580 QLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGH 639

Query: 737 ASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGF 794
           A +ILIVDWDVHHGNGTQ  F  DPSVLY+SLHR+D G FFP    GA  ++G  +G GF
Sbjct: 640 ALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGF 699

Query: 795 NVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHV 854
            VNVAW G   P MGD +YLAA+  +V+PIA EF+P+LVLVSAGFDAA G   PLGG  V
Sbjct: 700 TVNVAWNG---PRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGD--PLGGCQV 754

Query: 855 SAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQK 914
           S + + ++T  LM LA G ++L LEGG++LT+I ++  AC  +LLG   DP       + 
Sbjct: 755 SPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLG---DPPPLLTLPRP 811

Query: 915 PNLNAIRSLEAVIRVHSKYW 934
           P   A+ S+   I+VH +YW
Sbjct: 812 PLSGALASITETIQVHRRYW 831



 Score =  242 bits (617), Expect = 1e-63
 Identities = 147/384 (38%), Positives = 209/384 (54%), Gaps = 32/384 (8%)

Query: 559 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 618
           TGL+ D  + +  C   D+   PE   R+ +I  +L + GL  +C   + R A  EEL  
Sbjct: 86  TGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELML 143

Query: 619 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDT-DTIWNELHSSNAA 677
           VHS  ++ L  T       ++ G+L  L                DT D+++   +S + A
Sbjct: 144 VHSLEYIDLMETTQY----MNEGELRVL---------------ADTYDSVYLHPNSYSCA 184

Query: 678 RWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKA 737
             A+GSV  L   V   E++NG A++RPPGHHA HS   G+C FN VA+A R  QQ+ + 
Sbjct: 185 CLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRI 244

Query: 738 SKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVD--EVGAGSGEGFN 795
            ++LIVDWDVHHG GTQ TF QDPSVLY S+HR++ G F+P   A +    G G G+G+ 
Sbjct: 245 RRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYT 304

Query: 796 VNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS 855
           +NV W       M D +Y+AAF  V++P+A EF P LVLV+AGFDA +G P   G    +
Sbjct: 305 INVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPK--GEMAAT 359

Query: 856 AKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKP 915
              F  +T  LM LAGG ++L+LEGG++L A+ +   A +  LLG+    L   G    P
Sbjct: 360 PAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPG---AP 416

Query: 916 NLNAIRSLEAVIRVHSKYWGCMQR 939
             +A  S+   +     +W  + R
Sbjct: 417 CRSAQASVSCALEALEPFWEVLVR 440


>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
          Length = 669

 Score =  232 bits (592), Expect = 1e-60
 Identities = 145/383 (37%), Positives = 202/383 (52%), Gaps = 28/383 (7%)

Query: 559 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 618
           T L+Y   M   +    D     E   R+ +   RL++RGL  +C  L  R+AS EEL  
Sbjct: 3   TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62

Query: 619 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAAR 678
           VHS  +V L     +    L   +L  L  Q               D I+    + + AR
Sbjct: 63  VHSPEYVSLVRETQV----LGKEELQALSGQ--------------FDAIYFHPSTFHCAR 104

Query: 679 WAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKAS 738
            AAG+   L   V +  ++NG A+VRPPGHH   + A GFC FN+VAIA    +Q+    
Sbjct: 105 LAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLH 164

Query: 739 KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNV 796
           +IL+VDWDVHHG G Q  F  DPSVLY S HR++ G F+P       D VG G G GF V
Sbjct: 165 RILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTV 224

Query: 797 NVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA 856
           N+ W       MG+ +Y+AAF  +++P+A EF P+LVLVSAGFD+A G P   G    + 
Sbjct: 225 NLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE--GQMQATP 279

Query: 857 KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPN 916
           +CF ++TQ L  LAGG V   LEGG+ L ++ ++    V  LLG+   PLS       P 
Sbjct: 280 ECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLS---GPMAPC 336

Query: 917 LNAIRSLEAVIRVHSKYWGCMQR 939
            +A+ S+++     + +W  +Q+
Sbjct: 337 QSALESIQSARAAQAPHWKSLQQ 359



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 11/67 (16%)

Query: 813 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 872
           +L+    +V+P+A  F PDLVLV+ G     GH   L G H +      +   L  LAGG
Sbjct: 555 FLSCILGLVLPLAYGFQPDLVLVALG----PGH--GLQGPHAA-----LLAAMLRGLAGG 603

Query: 873 AVVLALE 879
            V+  LE
Sbjct: 604 RVLALLE 610


>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
          Length = 649

 Score =  197 bits (502), Expect = 3e-50
 Identities = 131/383 (34%), Positives = 186/383 (48%), Gaps = 48/383 (12%)

Query: 559 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 618
           T L+Y   M   +    D     E   R+ +   RL++RGL  +C  L  R+AS EEL  
Sbjct: 3   TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62

Query: 619 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAAR 678
           VHS  +V L     +    L   +L  L  Q               D I+    + + AR
Sbjct: 63  VHSPEYVSLVRETQV----LGKEELQALSGQ--------------FDAIYFHPSTFHCAR 104

Query: 679 WAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKAS 738
            AAG+   L   V +  ++NG A+VRPPGHH   + A GFC FN+VAIA    +Q+    
Sbjct: 105 LAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLH 164

Query: 739 KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNV 796
           +IL+VDWDVHHG G Q  F  DPSVLY S HR++ G F+P       D VG G G GF V
Sbjct: 165 RILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTV 224

Query: 797 NVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA 856
           N+ W       MG+ +Y+AAF  +++P+A E                      G    + 
Sbjct: 225 NLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQATP 259

Query: 857 KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPN 916
           +CF ++TQ L  LAGG V   LEGG+ L ++ ++    V  LLG+   PLS       P 
Sbjct: 260 ECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLS---GPMAPC 316

Query: 917 LNAIRSLEAVIRVHSKYWGCMQR 939
            +A+ S+++     + +W  +Q+
Sbjct: 317 QSALESIQSARAAQAPHWKSLQQ 339



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 11/67 (16%)

Query: 813 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 872
           +L+    +V+P+A  F PDLVLV+ G     GH   L G H +      +   L  LAGG
Sbjct: 535 FLSCILGLVLPLAYGFQPDLVLVALG----PGH--GLQGPHAA-----LLAAMLRGLAGG 583

Query: 873 AVVLALE 879
            V+  LE
Sbjct: 584 RVLALLE 590


>gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]
          Length = 590

 Score =  115 bits (287), Expect = 3e-25
 Identities = 139/475 (29%), Positives = 205/475 (43%), Gaps = 81/475 (17%)

Query: 59  LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115
           L  Q   +L  H+   LA  QQQ  +E   +L       E++   +EQ+L  L  KD+ +
Sbjct: 75  LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134

Query: 116 RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175
             AVAS+ VKQKL E +L K   +  +    N           L    A  + L    PP
Sbjct: 135 ERAVASTEVKQKLQEFLLSK---SATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191

Query: 176 VP--------SLP--SDPPEHFPLRKTVSEPNLKLRYKPK-KSLERRKNPLLRKE--SAP 222
           +         +LP   D  + FPLRKT SEPNLK+R + K K  ERR +PLLR++  +  
Sbjct: 192 LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251

Query: 223 PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG----------PNPILGSEALLGQRL 272
            S ++R  E     S  SSS+P SG SSPN+   G          P      + +  QR+
Sbjct: 252 TSFKKRMFEV--TESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRI 309

Query: 273 RLQETSVAPFALPTVSLLPAITLGLPA-PARADSDRRTHPTLGPRGPIL--GSPHTPLFL 329
            + E S+   +L T   LP ITLGLPA P++ ++              L  G P      
Sbjct: 310 LIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVP------ 363

Query: 330 PHGLEPEAGGTLP-SRLQPILLLD---PSGSHAPLL------------TVPGLGPLPFHF 373
              L  + GG++P S   P + L+   P+ SH  LL             +   G +P H 
Sbjct: 364 ---LPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP 420

Query: 374 AQSLMTTERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQV 426
              L T ER+S           H PL+RT+S PLP S  A         +L   + H Q 
Sbjct: 421 QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLA---------QLVIQQQHQQF 471

Query: 427 IKRSAKPSEKPRLRQI--PSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPA 479
           +++  +  ++  + ++   S E L+     PG  +++  E  +      E R P+
Sbjct: 472 LEKQKQYQQQIHMNKLLSKSIEQLKQ----PGSHLEEAEEELQGDQAMQEDRAPS 522



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 51/210 (24%), Positives = 82/210 (39%), Gaps = 38/210 (18%)

Query: 76  LQQQRSVEPMRLSMDTPMPELQVG--PQEQELRQLLHKDKSKRSAVASSVVKQKLAEVIL 133
           L++++  E   L    P+P    G  P       +  + K   S+       Q L + +L
Sbjct: 347 LKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSS------HQALLQHLL 400

Query: 134 KKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTV 193
            K+Q   ++ +     G+P     PL    AT+  +S  +     LP     H PL +T 
Sbjct: 401 LKEQMRQQKLLVAG--GVPLHPQSPL----ATKERISPGIRGTHKLP----RHRPLNRTQ 450

Query: 194 SEP-------NLKLRYKPKKSLERRK--------NPLLRKE----SAPPS-LRRRPAETL 233
           S P        L ++ + ++ LE++K        N LL K       P S L     E  
Sbjct: 451 SAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQ 510

Query: 234 GDSSPSSSSTPASGCSSPNDSEHGPNPILG 263
           GD +      P+SG S+ +DS    +  LG
Sbjct: 511 GDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540


>gi|13128860 histone deacetylase 1 [Homo sapiens]
          Length = 482

 Score =  108 bits (270), Expect = 2e-23
 Identities = 85/318 (26%), Positives = 138/318 (43%), Gaps = 61/318 (19%)

Query: 580 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 639
           HP    RI+   + L   GL  + E  R  KA+ EE+   HS+ ++       L  ++ D
Sbjct: 28  HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKF-----LRSIRPD 82

Query: 640 NGKLAGLLAQRM--------------FVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVT 685
           N        QR               F  L  GG  V +    N+  +  A  WA G   
Sbjct: 83  NMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVASAVKLNKQQTDIAVNWAGGL-- 139

Query: 686 DLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDW 745
                                 HHA  S A GFC+ N + +A  +L +  +  ++L +D 
Sbjct: 140 ----------------------HHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDI 175

Query: 746 DVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLD 805
           D+HHG+G ++ FY    V+ +S H++  G +FPG+G + ++GAG G+ + VN     G+D
Sbjct: 176 DIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGID 233

Query: 806 PPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS----AKCFGY 861
               D  Y A F+ V+  +   F P  V++  G D+  G    LG ++++    AKC  +
Sbjct: 234 ----DESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGD--RLGCFNLTIKGHAKCVEF 287

Query: 862 MTQ---QLMNLAGGAVVL 876
           +      ++ L GG   +
Sbjct: 288 VKSFNLPMLMLGGGGYTI 305


>gi|116284376 histone deacetylase 2 [Homo sapiens]
          Length = 582

 Score =  104 bits (260), Expect = 4e-22
 Identities = 77/292 (26%), Positives = 125/292 (42%), Gaps = 54/292 (18%)

Query: 580 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 639
           HP    RI+   + L   GL  + E  R  KA+ EE+   HS+ ++       L  ++ D
Sbjct: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKF-----LRSIRPD 177

Query: 640 NGKLAGLLAQRM--------------FVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVT 685
           N        QR               F  L  GG  V      N   +  A  WA G   
Sbjct: 178 NMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL-- 234

Query: 686 DLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDW 745
                                 HHA  S A GFC+ N + +A  +L +  +  ++L +D 
Sbjct: 235 ----------------------HHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDI 270

Query: 746 DVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLD 805
           D+HHG+G ++ FY    V+ +S H++  G +FPG+G + ++GAG G+ + VN     G+D
Sbjct: 271 DIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID 328

Query: 806 PPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAK 857
               D  Y   F+ ++  +   + P  V++  G D+  G    LG ++++ K
Sbjct: 329 ----DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD--RLGCFNLTVK 374


>gi|8923769 histone deacetylase 8 [Homo sapiens]
          Length = 377

 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 65/190 (34%), Positives = 93/190 (48%), Gaps = 26/190 (13%)

Query: 708 HHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYIS 767
           HHA    A GFC+ N   +   +L++  K  +IL VD D+HHG+G +  F     V+ +S
Sbjct: 142 HHAKKDEASGFCYLNDAVLGILRLRR--KFERILYVDLDLHHGDGVEDAFSFTSKVMTVS 199

Query: 768 LHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIARE 827
           LH+   G FFPG+G V +VG G G  ++VNV    G+     D +Y      V+  + + 
Sbjct: 200 LHKFSPG-FFPGTGDVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQA 254

Query: 828 FSPDLVLVSAGFDAAEGHP------APLGGYHVSAKCFGYMTQ-QLMNLAGGAVVLALEG 880
           F+P  V++  G D   G P       P+G      KC  Y+ Q QL  L  G       G
Sbjct: 255 FNPKAVVLQLGADTIAGDPMCSFNMTPVG----IGKCLKYILQWQLATLILGG------G 304

Query: 881 GHDL--TAIC 888
           G++L  TA C
Sbjct: 305 GYNLANTARC 314


>gi|13128862 histone deacetylase 3 [Homo sapiens]
          Length = 428

 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 47/135 (34%), Positives = 74/135 (54%), Gaps = 9/135 (6%)

Query: 708 HHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYIS 767
           HHA    A GFC+ N + I   +L +     ++L +D D+HHG+G Q+ FY    V+ +S
Sbjct: 134 HHAKKFEASGFCYVNDIVIGILELLKYHP--RVLYIDIDIHHGDGVQEAFYLTDRVMTVS 191

Query: 768 LHRHDDGN-FFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAR 826
            H++  GN FFPG+G + EVGA SG  + +NV    G+D    D  Y   F+ V+  +  
Sbjct: 192 FHKY--GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGID----DQSYKHLFQPVINQVVD 245

Query: 827 EFSPDLVLVSAGFDA 841
            + P  +++  G D+
Sbjct: 246 FYQPTCIVLQCGADS 260


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 142/602 (23%), Positives = 194/602 (32%), Gaps = 103/602 (17%)

Query: 4   PGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPP-------------- 49
           P A    ++P +    P+    P P A  P   P  M     Q PP              
Sbjct: 336 PLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSL 395

Query: 50  ----VEPPPEP---------TLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTP--MP 94
               ++ PP P         T L     Q  H  L ++  Q Q S+        TP   P
Sbjct: 396 TSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSP 455

Query: 95  ELQVG---PQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGI 151
            LQ     P    L+  L    S  S+  +    Q L+ +     QA L   + P     
Sbjct: 456 PLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMP----- 510

Query: 152 PYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKS--LE 209
                 PLET+ +      S   P  SL + P E+ P   +++ P L+    P  +  LE
Sbjct: 511 ------PLETQSSLAP--PSLQTPPASLTTPPLENLP---SLAPPPLQTASAPLTTPHLE 559

Query: 210 RRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLG 269
               P      APPS    P  T    +PSS +TP               P L S  L G
Sbjct: 560 TPPCPAPCPLQAPPS----PLTTPPPETPSSIATPPPQAP----------PALASPPLQG 605

Query: 270 QRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFL 329
               L    ++P A P     P + L               P   P  P    P +PL  
Sbjct: 606 ----LPSPPLSPLATPPPQAPPXLAL--------------PPLQAPPSPPASPPLSPLAT 647

Query: 330 PHGLEPEAGGTLPSR-LQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGL 388
           P    P+A   L    LQ      PS       + P   P+             L+   L
Sbjct: 648 P---SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL 704

Query: 389 HWPLSRTRSEPLPPSATAPP--PPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAE 446
             P S   S P+ PSAT PP  PP    P L+   +       S   +  PR+  + +A 
Sbjct: 705 QVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAP 764

Query: 447 DLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHP-QVLLWEQQRLAGRLPRGSTG 505
            L+     P  +    L        +P  + P  L   P Q L        G+ P   + 
Sbjct: 765 PLQVPPSPPASLPMSPL-------AKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSA 817

Query: 506 DTVLLPLAQGGHR-------PLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFT 558
              + PLA    +       PL +   SP A  +L AP         +S   P  TL   
Sbjct: 818 SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALA 877

Query: 559 TG 560
            G
Sbjct: 878 PG 879



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 139/553 (25%), Positives = 195/553 (35%), Gaps = 100/553 (18%)

Query: 27  RPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMR 86
           RP +  P   P    L +   PP++    P +  L  P  +H    L+ L          
Sbjct: 446 RPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASH------- 498

Query: 87  LSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQ--KLAEVILKKQQAALERTV 144
            S   P+  L + P E +        ++  +++ +  ++    LA   L+   A L  T 
Sbjct: 499 -SPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPL-TTP 556

Query: 145 HPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKP 204
           H  +P  P     PL+   A  S L++  P  PS  + PP   P    ++ P L+    P
Sbjct: 557 HLETPPCPAPC--PLQ---APPSPLTTPPPETPSSIATPPPQAP--PALASPPLQGLPSP 609

Query: 205 KKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGS 264
             S      P      APP L   P +     SP  +S P S  ++P  S   PN     
Sbjct: 610 PLSPLATPPP-----QAPPXLALPPLQ--APPSP-PASPPLSPLATP--SPQAPN----- 654

Query: 265 EALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPH 324
            AL    L+      APF+ P            P+P          P   P  P    P 
Sbjct: 655 -ALAVHLLQ------APFSPP------------PSP----------PVQAPFSPPASPPV 685

Query: 325 TPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLS 384
           +P   P    P      PS   P L + PS   +P ++ P   P P            L+
Sbjct: 686 SPSATPPSQAP------PSLAAPPLQVPPSPPASPPMS-PSATPPP-------QAPPPLA 731

Query: 385 GSGLHWPLSRTRSEPLPPSATAPP--PPGPMQPRLEQLKTHVQVIKRS--AKPSEK--PR 438
              L  P S   S P+ PSAT PP  PP    P L+   +    +  S  AKP  +  P 
Sbjct: 732 APPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPA 791

Query: 439 LRQIPSAEDLETDGGGPGQV---VDDGLEHRELGHGQPEARG--PAPLQQHPQVLLWEQQ 493
           L   P           PGQ        L    L    P+A     APL Q P        
Sbjct: 792 LATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPT 851

Query: 494 RLAGRLP------RGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSS 547
             A R P         +G  + L LA G   P SR+ SS     +LS P+ A  +   S+
Sbjct: 852 LQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSS-----TLSGPDLAGHSS--SA 904

Query: 548 SETPARTLPFTTG 560
           + TP     + +G
Sbjct: 905 TSTPEELRGYDSG 917



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 109/440 (24%), Positives = 146/440 (33%), Gaps = 94/440 (21%)

Query: 163 GATRSMLSSFLPPVPSLPSD------PPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLL 216
           G TRS  +S   P    P+       PP        VS P        + S   R  PL 
Sbjct: 78  GPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPG-------RASGTTRPGPLG 130

Query: 217 RKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQE 276
           +K      LR    ET+     + +   ++  +       GP P   S A+  +R R   
Sbjct: 131 QK-----GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAM-ARRSRAAG 184

Query: 277 TSV-----APFALP---------TVSLLPAITLGLPAPARADSDRRTHPTLG-----PRG 317
           T V     AP A P         +VS     +   P+PA      R  P+ G     P  
Sbjct: 185 TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA-----RRRPSAGGGLQRPAS 239

Query: 318 PILGSPHTPLFLPHGLEPEAGGTL-----PSRLQP--ILLLDPSGSHAPLL-TVPGLGPL 369
             L S  TPL  P    P A GT      PS+ +P  +  L P     P     P LGPL
Sbjct: 240 RSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 299

Query: 370 PFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKR 429
               + S + T   SG         T++ P+PP   A  P     P    L T + +   
Sbjct: 300 ----SSSPLATPSPSG---------TKARPVPPPDNAATPLPATLPPSPPLATPLPLAPP 346

Query: 430 SAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLL 489
           S  PS  P L+ +PS          P                 P  + P  LQ  P + +
Sbjct: 347 S--PSAPPSLQTLPSPPATPPSQAPPSMTT-------------PPMQAPPSLQTIPPIQV 391

Query: 490 WEQ------QRLAGRLPRGSTGDTVLL--PLAQGGH-------RPLSRAQSSPAAPASLS 534
                    Q     L   S   T  L  P  Q  H       R    + +SP+ PAS  
Sbjct: 392 PHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTP 451

Query: 535 APEPASQARVLSSSETPART 554
              P  QA +   +  P +T
Sbjct: 452 PDSPPLQAPLSLPASPPLQT 471



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 110/475 (23%), Positives = 157/475 (33%), Gaps = 79/475 (16%)

Query: 113 KSKRSAVASSVVKQKLAEVILKKQ-QAALERTVHPNSPGIPYRTLEPLETEGATRSMLSS 171
           K  R +   +V + K  E   +    A   R     +PG P   +        T   L  
Sbjct: 132 KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR 191

Query: 172 FLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAE 231
              P PS    PP   P RK+VS  +     +P                  P+ RRRP+ 
Sbjct: 192 ---PAPSARPRPPTEGP-RKSVSSASEHSTTEPS-----------------PAARRRPSA 230

Query: 232 TLGDSSP-----SSSSTPASGCSSPNDSEHG----------PNPILGSEALLGQRLRLQE 276
             G   P     SSS+TP S  +    S  G          P P  G +AL   ++    
Sbjct: 231 GGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKP-KGLQALRPPQVTPPR 289

Query: 277 TSVAP-----FALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPH 331
              AP      + P  +  P+ T   P P   D+     P   P  P L +P  PL  P 
Sbjct: 290 KDAAPALGPLSSSPLATPSPSGTKARPVPP-PDNAATPLPATLPPSPPLATP-LPLAPPS 347

Query: 332 GLEPEAGGTLPS-RLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHW 390
              P +  TLPS    P     PS +  P+   P L  +P       +T+  L       
Sbjct: 348 PSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPL 407

Query: 391 PLSRTRSEPL--PPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLR---QIPSA 445
            LS  ++      P+  A      M PR  Q        + ++ P + P L+    +P++
Sbjct: 408 ALSSLQATTSLGSPTLQATHSFLTMSPRQTQASL-TSPSRPASTPPDSPPLQAPLSLPAS 466

Query: 446 EDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTG 505
             L+T        +                   +PL  HP   L     LA   P+    
Sbjct: 467 PPLQTSLSPAVSPLS------------------SPLTIHP---LQALSSLASHSPQAPLS 505

Query: 506 DTVLLPL-AQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTT 559
             ++ PL  Q    P     S    PASL+ P P      L+       + P TT
Sbjct: 506 SLIMPPLETQSSLAP----PSLQTPPASLTTP-PLENLPSLAPPPLQTASAPLTT 555



 Score = 38.9 bits (89), Expect = 0.024
 Identities = 116/480 (24%), Positives = 157/480 (32%), Gaps = 72/480 (15%)

Query: 20  PTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPP---EPTLLALQRPQRLHHHLFLAGL 76
           P  A CP     +P   P P        PP + PP    P L  L  P        L+ L
Sbjct: 562 PCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPP-------LSPL 614

Query: 77  QQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQ 136
                  P  L++  P+      P    L  L        +A+A  +++   +       
Sbjct: 615 ATPPPQAPPXLAL-PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV 673

Query: 137 QA--------ALERTVHPNSPGIPYRTLEPLE---TEGATRSMLSSFLPPVPSLP--SDP 183
           QA         +  +  P S   P     PL+   +  A+  M  S  PP  + P  + P
Sbjct: 674 QAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP 733

Query: 184 PEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPP-SLRRRP-AETLGDSSPSSS 241
           P   P     S P       P +       P L+   +PP SL   P A+    + P+ +
Sbjct: 734 PLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALA 793

Query: 242 STPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAP-FALPTVSLLPAITLGLPAP 300
           + P     SP  S  G  P   S +L    L        P  A P + + P+     PA 
Sbjct: 794 TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPS----PPAS 849

Query: 301 ARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL 360
               + RR  PT GP   + G P   L L  G  P                 PS S +  
Sbjct: 850 PTLQAPRRP-PTPGPDTSVSG-PRLTLALAPGPPP----------------PPSRSPSST 891

Query: 361 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL 420
           L+ P L     H + +  T E L G           S P   +A +PPP        E  
Sbjct: 892 LSGPDLAG---HSSSATSTPEELRGYD---------SGPEGGAAASPPPDA------ELA 933

Query: 421 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP 480
             H     R   P+     R  P A        GPG    DGL       G PE+  PAP
Sbjct: 934 ACHPAAWSRG--PAPPLAFRGAPGAPLPWPPATGPGSA--DGLCTIYETEG-PESATPAP 988


>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
          Length = 347

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 69/278 (24%), Positives = 113/278 (40%), Gaps = 40/278 (14%)

Query: 580 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 639
           HP  AG+   + + L+E  L S    +  R+AS E+L  VH+ R+        L+ LK  
Sbjct: 35  HPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LNELKWS 86

Query: 640 NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG 699
              +A +      + LP   V      +   L +       AG +           ++ G
Sbjct: 87  FA-VATITEIPPVIFLPNFLV---QRKVLRPLRTQTGGTIMAGKLA----------VERG 132

Query: 700 FAVVRPPG-HHADHSTAMGFCFFNSVAIACRQLQQQSKA-SKILIVDWDVHHGNGTQQTF 757
           +A+    G HH       GFC +  + +A + L ++ +  S+  I+D D H GNG ++ F
Sbjct: 133 WAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDF 192

Query: 758 YQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAF 817
             D  V  + ++     + +PG     +  A       V + W         D EYL   
Sbjct: 193 MDDKRVYIMDVYNR---HIYPG-----DRFAKQAIRRKVELEWG------TEDDEYLDKV 238

Query: 818 RIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS 855
              +    +E  PD+V+ +AG D  EG    LGG  +S
Sbjct: 239 ERNIKKSLQEHLPDVVVYNAGTDILEGD--RLGGLSIS 274


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 114/419 (27%), Positives = 149/419 (35%), Gaps = 60/419 (14%)

Query: 164 ATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLL---RKES 220
           A+RS+ SS  P      S P      R T   P    + KPK  L+  + P +   RK++
Sbjct: 229 ASRSLSSSATPLSSPARSGPSA----RGTPRAPAHPSQPKPK-GLQALRPPQVTPPRKDA 283

Query: 221 APP--SLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPI---LGSEALLGQRLRLQ 275
           AP    L   P  T   S+P S S P S  + P+     P+     LGS  L      L 
Sbjct: 284 APALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP 343

Query: 276 ETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEP 335
              ++P A P     PA+ L               P   P  P    P +PL  P    P
Sbjct: 344 SPPLSPLATPPPQAPPALALP--------------PLQAPPSPPASPPLSPLATP---SP 386

Query: 336 EAGGTLPSRL-QPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSR 394
           +A   L   L Q      PS       + P   P+             L+   L  P S 
Sbjct: 387 QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP 446

Query: 395 TRSEPLPPSATAPP--PPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDG 452
             S P+ PSAT PP  PP    P L+  K   Q     A P     L+ +PS        
Sbjct: 447 PASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPP----LQALPS-----PPA 497

Query: 453 GGPGQV---VDDGLEHRELGHGQPEARG--PAPLQQHPQVLLWEQQRLAGRLP------R 501
             PGQ        L    L    P+A     APL Q P          A R P       
Sbjct: 498 SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 557

Query: 502 GSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTG 560
             +G  + L LA G   P SR+ SS     +LS P+ A  +   S++ TP     + +G
Sbjct: 558 SVSGPRLTLALAPGPPPPPSRSPSS-----TLSGPDLAGHSS--SATSTPEELRGYDSG 609



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 124/492 (25%), Positives = 161/492 (32%), Gaps = 87/492 (17%)

Query: 113 KSKRSAVASSVVKQKLAEVILKKQ-QAALERTVHPNSPGIPYRTLEPLETEGATRSMLSS 171
           K  R +   +V + K  E   +    A   R     +PG P   +        T   L  
Sbjct: 123 KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR 182

Query: 172 FLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAE 231
              P PS    PP   P RK+VS  +     +P                  P+ RRRP+ 
Sbjct: 183 ---PAPSARPRPPTEGP-RKSVSSASEHSTTEPS-----------------PAARRRPSA 221

Query: 232 TLGDSSP-----SSSSTPASGCSSPNDSEHG----------PNPILGSEALLGQRLRLQE 276
             G   P     SSS+TP S  +    S  G          P P  G +AL   ++    
Sbjct: 222 GGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKP-KGLQALRPPQVTPPR 280

Query: 277 TSVAPFALPTVSLLPAITLGLPAP--ARADSDRRTHPTLGPRGP-----ILGSP---HTP 326
              AP AL  +S  P  T    AP    A    +T P+     P      LGSP    T 
Sbjct: 281 KDAAP-ALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH 339

Query: 327 LFLPH-GLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPL--PFHFAQSLMTTERL 383
            FLP   L P A  T P +  P L L P  +       P L PL  P   A + +    L
Sbjct: 340 SFLPSPPLSPLA--TPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLL 397

Query: 384 S-------GSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEK 436
                      +  P S   S P+ PSAT   PP    P L            +A P + 
Sbjct: 398 QAPFSPPPSPPVQAPFSPPASPPVSPSAT---PPSQAPPSL------------AAPPLQV 442

Query: 437 PRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHP-QVLLWEQQRL 495
           P     P A    +    P       L    L   +P  + P  L   P Q L       
Sbjct: 443 P---PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASF 499

Query: 496 AGRLPRGSTGDTVLLPLAQGGHR-------PLSRAQSSPAAPASLSAPEPASQARVLSSS 548
            G+ P   +    + PLA    +       PL +   SP A  +L AP         +S 
Sbjct: 500 PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSV 559

Query: 549 ETPARTLPFTTG 560
             P  TL    G
Sbjct: 560 SGPRLTLALAPG 571



 Score = 38.5 bits (88), Expect = 0.032
 Identities = 93/394 (23%), Positives = 130/394 (32%), Gaps = 74/394 (18%)

Query: 20  PTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQ 79
           P+  G PR  A     QP+P  L+  + P V PP +    AL                  
Sbjct: 248 PSARGTPR--APAHPSQPKPKGLQALRPPQVTPPRKDAAPAL------------------ 287

Query: 80  RSVEPMRLS-MDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQA 138
               P+  S + TP P     P      Q L        A   S     L    L+   +
Sbjct: 288 ---GPLSSSPLATPSPSAPPSPSAPPSLQTL----PSPPATPPSQATTSLGSPTLQATHS 340

Query: 139 ALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPV---PSLPSDPPEHFPLRKTVSE 195
            L     P+ P  P  T  P       ++  +  LPP+   PS P+ PP       +   
Sbjct: 341 FL-----PSPPLSPLATPPP-------QAPPALALPPLQAPPSPPASPPLSPLATPSPQA 388

Query: 196 PNLKLRYKPKKSLERRKNPLLRKESAPP-SLRRRPAETLGDSSPSSSS-----TPASGCS 249
           PN    +  +       +P ++   +PP S    P+ T    +P S +      P S  +
Sbjct: 389 PNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA 448

Query: 250 SPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRT 309
           SP  S     P      L    L+L +    P A P ++  P     LP+P        +
Sbjct: 449 SPPMSPSATPPPQAPPPLAAPPLQLAKP--PPQAPPALATPP--LQALPSPP------AS 498

Query: 310 HPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPL 369
            P   P  P    P +PL  P    P      P    P+L + PS   +P L  P   P 
Sbjct: 499 FPGQAPFSPSASLPMSPLATPPPQAP------PVLAAPLLQVPPSPPASPTLQAPRRPPT 552

Query: 370 PFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPS 403
           P             S SG    L+     P PPS
Sbjct: 553 P---------GPDTSVSGPRLTLALAPGPPPPPS 577



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 75/290 (25%), Positives = 92/290 (31%), Gaps = 61/290 (21%)

Query: 174 PPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPS----LRRRP 229
           P  P  P  PP   P    V      +  KP              ESAP +      R P
Sbjct: 27  PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPP 86

Query: 230 AETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFA--LPTV 287
           A   G+ +P + +T     SSP  +     P  G     G R+  +ET     A   P  
Sbjct: 87  ASGRGERAPPAKNTSPGPVSSPGRASGTTRP--GPLGQKGLRISAEETVARGKATEAPKR 144

Query: 288 SLLPA--------ITLGLPAPAR----------------ADSDRRTHPTLGPRGPILGSP 323
           S L A         T G P+PA                 A S R   PT GPR  +  + 
Sbjct: 145 SALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSAS 204

Query: 324 HTPLFLPHGL---EPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGP-------LPFHF 373
                 P       P AGG L       L    S S  PL +    GP        P H 
Sbjct: 205 EHSTTEPSPAARRRPSAGGGLQRPASRSL----SSSATPLSSPARSGPSARGTPRAPAHP 260

Query: 374 AQ-----------SLMTTERLSGSGLHWPLS----RTRSEPLPPSATAPP 408
           +Q             +T  R   +    PLS     T S   PPS +APP
Sbjct: 261 SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPP 310


>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
          Length = 296

 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 67/279 (24%), Positives = 104/279 (37%), Gaps = 65/279 (23%)

Query: 580 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 639
           HP  AG+   + + L+E  L S    +  R+AS E+L  VH+ R++       L  L+  
Sbjct: 7   HPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKRKVLRPLRTQ 66

Query: 640 NGK--LAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELK 697
            G   +AG LA      +  GG                                      
Sbjct: 67  TGGTIMAGKLAVERGWAINVGG-------------------------------------- 88

Query: 698 NGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKA-SKILIVDWDVHHGNGTQQT 756
            GF       HH       GFC +  + +A + L ++ +  S+  I+D D H GNG ++ 
Sbjct: 89  -GF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERD 140

Query: 757 FYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAA 816
           F  D  V  + ++     + +PG     +  A       V + W         D EYL  
Sbjct: 141 FMDDKRVYIMDVYNR---HIYPG-----DRFAKQAIRRKVELEWG------TEDDEYLDK 186

Query: 817 FRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS 855
               +    +E  PD+V+ +AG D  EG    LGG  +S
Sbjct: 187 VERNIKKSLQEHLPDVVVYNAGTDILEGD--RLGGLSIS 223


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 119/567 (20%), Positives = 178/567 (31%), Gaps = 71/567 (12%)

Query: 3   SPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQ 62
           +P A+ T   P            P+  A T   +P P  ++     P EP P  T  A  
Sbjct: 198 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 257

Query: 63  RPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASS 122
            P+                 EP   +   P P     P          K+ +  +  ++ 
Sbjct: 258 TPK-----------------EPAPTTTKEPAPTTPKEPAPTTT-----KEPAPTTTKSAP 295

Query: 123 VVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSD 182
              ++ A    KK      +   P +P  P  T  P E    T+        P P+ P +
Sbjct: 296 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT-PKEPAPTTKE-------PAPTTPKE 347

Query: 183 PPEHFPLRK---TVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPS 239
           P    P +    T  EP      +P  +  +  +P   KE AP + +  P  T   +  +
Sbjct: 348 PAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 407

Query: 240 SSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPA-ITLGLP 298
           + S P +       +   P P    E       +   T+    A PT    PA  T   P
Sbjct: 408 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPAPTTTKKP 466

Query: 299 APARADSDRRTHP-TLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGS- 356
           AP        T P    P  P   +P TP  L      +   T P  L P    +P+ + 
Sbjct: 467 APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTT 526

Query: 357 -HAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLP--PSATAPPPPGPM 413
              P  T P         A +  T +  + +    P   T  EP P  P  TAP  P   
Sbjct: 527 PEEPAPTTPK--------AAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 578

Query: 414 QPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQP 473
            P    LK       +   P E   L    + E   T    P      G           
Sbjct: 579 AP--TTLKEPAPTTPKKPAPKE---LAPTTTKEPTSTTCDKPAPTTPKGT-------APT 626

Query: 474 EARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSR--AQSSPAAPA 531
             + PAP            +  A   P+G+   T+  P      +P  +  A ++   P 
Sbjct: 627 TPKEPAPT---------TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 677

Query: 532 SLSAPEPASQARVLSSSETPARTLPFT 558
           S ++ +PA      ++  TP    P T
Sbjct: 678 STTSDKPAPTTPKETAPTTPKEPAPTT 704



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 73/369 (19%), Positives = 123/369 (33%), Gaps = 39/369 (10%)

Query: 88  SMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPN 147
           ++  P P     P  +EL     K+ +  +    +    K       K+ A       P 
Sbjct: 582 TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA-------PT 634

Query: 148 SPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKS 207
           +P  P     P   +G   + L     P P+ P  P        T   P      KP  +
Sbjct: 635 TPKEP----APTTPKGTAPTTLKE---PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT 687

Query: 208 LERRKNPLLRKESAP-------PSLRRRPAETLGD-SSPSSSSTPASGCSSPNDSEHGPN 259
             +   P   KE AP       P+    P  T  + S+P+++  P +   SP++S     
Sbjct: 688 TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES----T 743

Query: 260 PILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPAR---ADSDRRTHPTLGPR 316
           P L +E       +  E S     +PT     A    +   A+    + D RT P     
Sbjct: 744 PELSAE----PTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA 799

Query: 317 GPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQS 376
            P + +  T        E +   T  +++      D +      L    L P      ++
Sbjct: 800 APKM-TKETATTTEKTTESKITAT-TTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKT 857

Query: 377 LMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQ-PRLEQLKTHVQVIKRSAKPSE 435
           + TTE ++        ++ +       AT P P  P + P+        + + R  KP  
Sbjct: 858 ITTTEIMNKPE---ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKT 914

Query: 436 KPRLRQIPS 444
            P  R++ S
Sbjct: 915 TPTPRKMTS 923


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 119/567 (20%), Positives = 178/567 (31%), Gaps = 71/567 (12%)

Query: 3   SPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQ 62
           +P A+ T   P            P+  A T   +P P  ++     P EP P  T  A  
Sbjct: 239 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 298

Query: 63  RPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASS 122
            P+                 EP   +   P P     P          K+ +  +  ++ 
Sbjct: 299 TPK-----------------EPAPTTTKEPAPTTPKEPAPTTT-----KEPAPTTTKSAP 336

Query: 123 VVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSD 182
              ++ A    KK      +   P +P  P  T  P E    T+        P P+ P +
Sbjct: 337 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT-PKEPAPTTKE-------PAPTTPKE 388

Query: 183 PPEHFPLRK---TVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPS 239
           P    P +    T  EP      +P  +  +  +P   KE AP + +  P  T   +  +
Sbjct: 389 PAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 448

Query: 240 SSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPA-ITLGLP 298
           + S P +       +   P P    E       +   T+    A PT    PA  T   P
Sbjct: 449 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPAPTTTKKP 507

Query: 299 APARADSDRRTHP-TLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGS- 356
           AP        T P    P  P   +P TP  L      +   T P  L P    +P+ + 
Sbjct: 508 APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTT 567

Query: 357 -HAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLP--PSATAPPPPGPM 413
              P  T P         A +  T +  + +    P   T  EP P  P  TAP  P   
Sbjct: 568 PEEPAPTTPK--------AAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 619

Query: 414 QPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQP 473
            P    LK       +   P E   L    + E   T    P      G           
Sbjct: 620 AP--TTLKEPAPTTPKKPAPKE---LAPTTTKEPTSTTCDKPAPTTPKGT-------APT 667

Query: 474 EARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSR--AQSSPAAPA 531
             + PAP            +  A   P+G+   T+  P      +P  +  A ++   P 
Sbjct: 668 TPKEPAPT---------TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 718

Query: 532 SLSAPEPASQARVLSSSETPARTLPFT 558
           S ++ +PA      ++  TP    P T
Sbjct: 719 STTSDKPAPTTPKETAPTTPKEPAPTT 745



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 73/369 (19%), Positives = 123/369 (33%), Gaps = 39/369 (10%)

Query: 88  SMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPN 147
           ++  P P     P  +EL     K+ +  +    +    K       K+ A       P 
Sbjct: 623 TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA-------PT 675

Query: 148 SPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKS 207
           +P  P     P   +G   + L     P P+ P  P        T   P      KP  +
Sbjct: 676 TPKEP----APTTPKGTAPTTLKE---PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT 728

Query: 208 LERRKNPLLRKESAP-------PSLRRRPAETLGD-SSPSSSSTPASGCSSPNDSEHGPN 259
             +   P   KE AP       P+    P  T  + S+P+++  P +   SP++S     
Sbjct: 729 TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES----T 784

Query: 260 PILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPAR---ADSDRRTHPTLGPR 316
           P L +E       +  E S     +PT     A    +   A+    + D RT P     
Sbjct: 785 PELSAE----PTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA 840

Query: 317 GPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQS 376
            P + +  T        E +   T  +++      D +      L    L P      ++
Sbjct: 841 APKM-TKETATTTEKTTESKITAT-TTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKT 898

Query: 377 LMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQ-PRLEQLKTHVQVIKRSAKPSE 435
           + TTE ++        ++ +       AT P P  P + P+        + + R  KP  
Sbjct: 899 ITTTEIMNKPE---ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKT 955

Query: 436 KPRLRQIPS 444
            P  R++ S
Sbjct: 956 TPTPRKMTS 964


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 119/567 (20%), Positives = 178/567 (31%), Gaps = 71/567 (12%)

Query: 3   SPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQ 62
           +P A+ T   P            P+  A T   +P P  ++     P EP P  T  A  
Sbjct: 291 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 350

Query: 63  RPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASS 122
            P+                 EP   +   P P     P          K+ +  +  ++ 
Sbjct: 351 TPK-----------------EPAPTTTKEPAPTTPKEPAPTTT-----KEPAPTTTKSAP 388

Query: 123 VVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSD 182
              ++ A    KK      +   P +P  P  T  P E    T+        P P+ P +
Sbjct: 389 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT-PKEPAPTTKE-------PAPTTPKE 440

Query: 183 PPEHFPLRK---TVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPS 239
           P    P +    T  EP      +P  +  +  +P   KE AP + +  P  T   +  +
Sbjct: 441 PAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 500

Query: 240 SSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPA-ITLGLP 298
           + S P +       +   P P    E       +   T+    A PT    PA  T   P
Sbjct: 501 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPAPTTTKKP 559

Query: 299 APARADSDRRTHP-TLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGS- 356
           AP        T P    P  P   +P TP  L      +   T P  L P    +P+ + 
Sbjct: 560 APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTT 619

Query: 357 -HAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLP--PSATAPPPPGPM 413
              P  T P         A +  T +  + +    P   T  EP P  P  TAP  P   
Sbjct: 620 PEEPAPTTPK--------AAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 671

Query: 414 QPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQP 473
            P    LK       +   P E   L    + E   T    P      G           
Sbjct: 672 AP--TTLKEPAPTTPKKPAPKE---LAPTTTKEPTSTTCDKPAPTTPKGT-------APT 719

Query: 474 EARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSR--AQSSPAAPA 531
             + PAP            +  A   P+G+   T+  P      +P  +  A ++   P 
Sbjct: 720 TPKEPAPT---------TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 770

Query: 532 SLSAPEPASQARVLSSSETPARTLPFT 558
           S ++ +PA      ++  TP    P T
Sbjct: 771 STTSDKPAPTTPKETAPTTPKEPAPTT 797



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 73/369 (19%), Positives = 123/369 (33%), Gaps = 39/369 (10%)

Query: 88   SMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPN 147
            ++  P P     P  +EL     K+ +  +    +    K       K+ A       P 
Sbjct: 675  TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA-------PT 727

Query: 148  SPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKS 207
            +P  P     P   +G   + L     P P+ P  P        T   P      KP  +
Sbjct: 728  TPKEP----APTTPKGTAPTTLKE---PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT 780

Query: 208  LERRKNPLLRKESAP-------PSLRRRPAETLGD-SSPSSSSTPASGCSSPNDSEHGPN 259
              +   P   KE AP       P+    P  T  + S+P+++  P +   SP++S     
Sbjct: 781  TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES----T 836

Query: 260  PILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPAR---ADSDRRTHPTLGPR 316
            P L +E       +  E S     +PT     A    +   A+    + D RT P     
Sbjct: 837  PELSAE----PTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA 892

Query: 317  GPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQS 376
             P + +  T        E +   T  +++      D +      L    L P      ++
Sbjct: 893  APKM-TKETATTTEKTTESKITAT-TTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKT 950

Query: 377  LMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQ-PRLEQLKTHVQVIKRSAKPSE 435
            + TTE ++        ++ +       AT P P  P + P+        + + R  KP  
Sbjct: 951  ITTTEIMNKPE---ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKT 1007

Query: 436  KPRLRQIPS 444
             P  R++ S
Sbjct: 1008 TPTPRKMTS 1016


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 119/567 (20%), Positives = 178/567 (31%), Gaps = 71/567 (12%)

Query: 3   SPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQ 62
           +P A+ T   P            P+  A T   +P P  ++     P EP P  T  A  
Sbjct: 332 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 391

Query: 63  RPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASS 122
            P+                 EP   +   P P     P          K+ +  +  ++ 
Sbjct: 392 TPK-----------------EPAPTTTKEPAPTTPKEPAPTTT-----KEPAPTTTKSAP 429

Query: 123 VVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSD 182
              ++ A    KK      +   P +P  P  T  P E    T+        P P+ P +
Sbjct: 430 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT-PKEPAPTTKE-------PAPTTPKE 481

Query: 183 PPEHFPLRK---TVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPS 239
           P    P +    T  EP      +P  +  +  +P   KE AP + +  P  T   +  +
Sbjct: 482 PAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 541

Query: 240 SSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPA-ITLGLP 298
           + S P +       +   P P    E       +   T+    A PT    PA  T   P
Sbjct: 542 TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA-PTTPKEPAPTTTKKP 600

Query: 299 APARADSDRRTHP-TLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGS- 356
           AP        T P    P  P   +P TP  L      +   T P  L P    +P+ + 
Sbjct: 601 APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTT 660

Query: 357 -HAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLP--PSATAPPPPGPM 413
              P  T P         A +  T +  + +    P   T  EP P  P  TAP  P   
Sbjct: 661 PEEPAPTTPK--------AAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 712

Query: 414 QPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQP 473
            P    LK       +   P E   L    + E   T    P      G           
Sbjct: 713 AP--TTLKEPAPTTPKKPAPKE---LAPTTTKEPTSTTCDKPAPTTPKGT-------APT 760

Query: 474 EARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSR--AQSSPAAPA 531
             + PAP            +  A   P+G+   T+  P      +P  +  A ++   P 
Sbjct: 761 TPKEPAPT---------TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT 811

Query: 532 SLSAPEPASQARVLSSSETPARTLPFT 558
           S ++ +PA      ++  TP    P T
Sbjct: 812 STTSDKPAPTTPKETAPTTPKEPAPTT 838



 Score = 30.8 bits (68), Expect = 6.6
 Identities = 73/369 (19%), Positives = 123/369 (33%), Gaps = 39/369 (10%)

Query: 88   SMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPN 147
            ++  P P     P  +EL     K+ +  +    +    K       K+ A       P 
Sbjct: 716  TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA-------PT 768

Query: 148  SPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKS 207
            +P  P     P   +G   + L     P P+ P  P        T   P      KP  +
Sbjct: 769  TPKEP----APTTPKGTAPTTLKE---PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT 821

Query: 208  LERRKNPLLRKESAP-------PSLRRRPAETLGD-SSPSSSSTPASGCSSPNDSEHGPN 259
              +   P   KE AP       P+    P  T  + S+P+++  P +   SP++S     
Sbjct: 822  TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES----T 877

Query: 260  PILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPAR---ADSDRRTHPTLGPR 316
            P L +E       +  E S     +PT     A    +   A+    + D RT P     
Sbjct: 878  PELSAE----PTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA 933

Query: 317  GPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQS 376
             P + +  T        E +   T  +++      D +      L    L P      ++
Sbjct: 934  APKM-TKETATTTEKTTESKITAT-TTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKT 991

Query: 377  LMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQ-PRLEQLKTHVQVIKRSAKPSE 435
            + TTE ++        ++ +       AT P P  P + P+        + + R  KP  
Sbjct: 992  ITTTEIMNKPE---ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKT 1048

Query: 436  KPRLRQIPS 444
             P  R++ S
Sbjct: 1049 TPTPRKMTS 1057


>gi|41281612 zinc finger protein 828 [Homo sapiens]
          Length = 812

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 99/400 (24%), Positives = 144/400 (36%), Gaps = 81/400 (20%)

Query: 77  QQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQ 136
           Q  +  +P++     P+PE Q  P               +S  A S+  QKL  V+    
Sbjct: 98  QLNKETDPVK---SPPLPEHQKIPCNSA---------EPKSIPALSMETQKLGSVL---- 141

Query: 137 QAALERTVHPNSPG-IPYRTLEPLETEGATRSMLSSFLP-PVPSLPS-----DPPEHFPL 189
                    P SP   P   LEP +        L + LP P PS P+     +PP+  P+
Sbjct: 142 --------SPESPKPTPLTPLEPQKPGSVVSPELQTPLPSPEPSKPASVSSPEPPKSVPV 193

Query: 190 RKTVS-------EPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSS 242
            ++         EP       P+       NP  +K+S  P       ETLG   P S+S
Sbjct: 194 CESQKLAPVPSPEPQKPAPVSPESVKATLSNPKPQKQSHFP-------ETLG---PPSAS 243

Query: 243 TPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPAR 302
           +P S   + +    GP+P    E+    R   + TS  P   P+ S  P      P PA 
Sbjct: 244 SPESPVLAASPEPWGPSPAASPES----RKSARTTSPEP-RKPSPSESP--EPWKPFPAV 296

Query: 303 ADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLT 362
           +   RR  P + P     G P +P   P    P A        +P     PS S  P   
Sbjct: 297 SPEPRRPAPAVSPGSWKPGPPGSP--RPWKSNPSASSGPWKPAKPA----PSVSPGPWKP 350

Query: 363 VPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQ-----PRL 417
           +P + P P+    S+        S   W     +S  + PS+   PP  P       P L
Sbjct: 351 IPSVSPGPWKPTPSV--------SSASW-----KSSSVSPSSWKSPPASPESWKSGPPEL 397

Query: 418 EQLKTHVQVIKRSAKPSEKPRLRQ--IPSAEDLETDGGGP 455
            +    +      A P   P LR+   P + ++ +  G P
Sbjct: 398 RKTAPTLSPEHWKAVPPVSPELRKPGPPLSPEIRSPAGSP 437


>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 139/604 (23%), Positives = 188/604 (31%), Gaps = 90/604 (14%)

Query: 4   PGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQR 63
           P   G    P      P G G P P   +  P P P+ L     P + PPP P L AL  
Sbjct: 141 PPPPGPAPGPPQDISEPPG-GSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199

Query: 64  PQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSV 123
           P  L                P+      P P     P        +      R      V
Sbjct: 200 PHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTV----GTRLFPPGGV 255

Query: 124 VKQKLAEVILKKQQAALERTVHPNSPGIPY-RTLEPLETEGATRSMLSSFLPPVPSLPSD 182
            K K ++V L  +QA   R   P SP  P    L P      T        PP P     
Sbjct: 256 TKWK-SDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPV---- 310

Query: 183 PPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSS 242
                   +T S P  + +  P+K     K    R    PPS   RPA     S      
Sbjct: 311 --------RTSSIPVQEAQEAPRKEEGATKKAPSRL-PLPPSFHIRPA-----SQVYPDR 356

Query: 243 TPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLP--AP 300
            P   C     +    +P LG         R      AP   P    LP     LP  AP
Sbjct: 357 APEPDCPGELKATAPASPRLGQSQSQADE-RAGTPPPAPPLPPPAPPLPPPAPPLPPAAP 415

Query: 301 ARADSDRRTHPTLG-PRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSG---- 355
               + +  HP  G  + P      +P   P    P    T  S   P+   DPS     
Sbjct: 416 PLPCAQKAAHPPAGFTKTP---KSSSPALKPKPNPPSPENTASS--APVDWRDPSQMEKL 470

Query: 356 ------------------SHAPLLTVP------GLGP----------LPFHFAQSLMTTE 381
                             SH P  TV         GP          LP       +  +
Sbjct: 471 RNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEK 530

Query: 382 RLSGSGLHWPLSRTRSEPLP----PSATAPPPPGPMQPRLEQLKTHVQV-IKRSAKPSEK 436
            L GS L      T +E  P    PS    P   P  P + Q++  ++  +  +A+   K
Sbjct: 531 SLGGSSL------TETEAAPSLTLPSVDYIPQDSP-TPSVRQIRNELEARLSSAAEKEAK 583

Query: 437 PRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLA 496
           P +  +P    LE      G++ ++G +  +L     +   P      P   L  +  L 
Sbjct: 584 PSIGSLPPKPRLE-----GGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLG 638

Query: 497 GRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAP-ASLSAPEPASQARVLSSSETPARTL 555
             +P  +T +  + P A        +A   PA P  + S P    +A    +  + A TL
Sbjct: 639 PAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTL 698

Query: 556 PFTT 559
           P TT
Sbjct: 699 PTTT 702



 Score = 34.7 bits (78), Expect = 0.46
 Identities = 89/408 (21%), Positives = 131/408 (32%), Gaps = 77/408 (18%)

Query: 172 FLPPVPSL----PSDPPEHFPLRKTVSEPN-LKLRYKPKKSLERRKNPLLRKESAPPSLR 226
           F+PP P L    P  PP   P     + P+ +  R  P   + + K+ +        +L 
Sbjct: 214 FIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDV--------ALN 265

Query: 227 RRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPT 286
            R AE    S P S + P      PN   H   P              +   V P     
Sbjct: 266 GRQAEATRASPPRSPAEPKGSALGPNPEPHLTFP--------------RSFKVPPPTPVR 311

Query: 287 VSLLPAITLGLPAPARADSDRRTHPTLGPRGPILG-SPHTPLFLPHGLEPEAGGTLPSRL 345
            S +P +     AP + +   +  P+  P  P     P + ++     EP+  G L +  
Sbjct: 312 TSSIP-VQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKAT- 369

Query: 346 QPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSAT 405
                       AP    P LG       QS    +  +G+    P     + PLPP A 
Sbjct: 370 ------------AP--ASPRLG-------QSQSQADERAGTPPPAPPLPPPAPPLPPPAP 408

Query: 406 APPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIP-------SAEDLETDGGGPGQV 458
             PP  P  P   Q   H          S  P L+  P       +A     D   P Q+
Sbjct: 409 PLPPAAPPLP-CAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQM 467

Query: 459 VDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHR 518
             + L +    +     R    L   P   +  Q +   + PR    +T+L         
Sbjct: 468 --EKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLL--------- 516

Query: 519 PLSRAQSSPAAPASLSAPEPASQARVLSSSE-TPARTLPFTTGLIYDS 565
                 S PA       PE +     L+ +E  P+ TLP    +  DS
Sbjct: 517 ------SLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDS 558


>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 139/604 (23%), Positives = 188/604 (31%), Gaps = 90/604 (14%)

Query: 4   PGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQR 63
           P   G    P      P G G P P   +  P P P+ L     P + PPP P L AL  
Sbjct: 141 PPPPGPAPGPPQDISEPPG-GSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199

Query: 64  PQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSV 123
           P  L                P+      P P     P        +      R      V
Sbjct: 200 PHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTV----GTRLFPPGGV 255

Query: 124 VKQKLAEVILKKQQAALERTVHPNSPGIPY-RTLEPLETEGATRSMLSSFLPPVPSLPSD 182
            K K ++V L  +QA   R   P SP  P    L P      T        PP P     
Sbjct: 256 TKWK-SDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPV---- 310

Query: 183 PPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSS 242
                   +T S P  + +  P+K     K    R    PPS   RPA     S      
Sbjct: 311 --------RTSSIPVQEAQEAPRKEEGATKKAPSRL-PLPPSFHIRPA-----SQVYPDR 356

Query: 243 TPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLP--AP 300
            P   C     +    +P LG         R      AP   P    LP     LP  AP
Sbjct: 357 APEPDCPGELKATAPASPRLGQSQSQADE-RAGTPPPAPPLPPPAPPLPPPAPPLPPAAP 415

Query: 301 ARADSDRRTHPTLG-PRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSG---- 355
               + +  HP  G  + P      +P   P    P    T  S   P+   DPS     
Sbjct: 416 PLPCAQKAAHPPAGFTKTP---KSSSPALKPKPNPPSPENTASS--APVDWRDPSQMEKL 470

Query: 356 ------------------SHAPLLTVP------GLGP----------LPFHFAQSLMTTE 381
                             SH P  TV         GP          LP       +  +
Sbjct: 471 RNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEK 530

Query: 382 RLSGSGLHWPLSRTRSEPLP----PSATAPPPPGPMQPRLEQLKTHVQV-IKRSAKPSEK 436
            L GS L      T +E  P    PS    P   P  P + Q++  ++  +  +A+   K
Sbjct: 531 SLGGSSL------TETEAAPSLTLPSVDYIPQDSP-TPSVRQIRNELEARLSSAAEKEAK 583

Query: 437 PRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLA 496
           P +  +P    LE      G++ ++G +  +L     +   P      P   L  +  L 
Sbjct: 584 PSIGSLPPKPRLE-----GGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLG 638

Query: 497 GRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAP-ASLSAPEPASQARVLSSSETPARTL 555
             +P  +T +  + P A        +A   PA P  + S P    +A    +  + A TL
Sbjct: 639 PAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTL 698

Query: 556 PFTT 559
           P TT
Sbjct: 699 PTTT 702



 Score = 34.7 bits (78), Expect = 0.46
 Identities = 89/408 (21%), Positives = 131/408 (32%), Gaps = 77/408 (18%)

Query: 172 FLPPVPSL----PSDPPEHFPLRKTVSEPN-LKLRYKPKKSLERRKNPLLRKESAPPSLR 226
           F+PP P L    P  PP   P     + P+ +  R  P   + + K+ +        +L 
Sbjct: 214 FIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDV--------ALN 265

Query: 227 RRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPT 286
            R AE    S P S + P      PN   H   P              +   V P     
Sbjct: 266 GRQAEATRASPPRSPAEPKGSALGPNPEPHLTFP--------------RSFKVPPPTPVR 311

Query: 287 VSLLPAITLGLPAPARADSDRRTHPTLGPRGPILG-SPHTPLFLPHGLEPEAGGTLPSRL 345
            S +P +     AP + +   +  P+  P  P     P + ++     EP+  G L +  
Sbjct: 312 TSSIP-VQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKAT- 369

Query: 346 QPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSAT 405
                       AP    P LG       QS    +  +G+    P     + PLPP A 
Sbjct: 370 ------------AP--ASPRLG-------QSQSQADERAGTPPPAPPLPPPAPPLPPPAP 408

Query: 406 APPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIP-------SAEDLETDGGGPGQV 458
             PP  P  P   Q   H          S  P L+  P       +A     D   P Q+
Sbjct: 409 PLPPAAPPLP-CAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQM 467

Query: 459 VDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHR 518
             + L +    +     R    L   P   +  Q +   + PR    +T+L         
Sbjct: 468 --EKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLL--------- 516

Query: 519 PLSRAQSSPAAPASLSAPEPASQARVLSSSE-TPARTLPFTTGLIYDS 565
                 S PA       PE +     L+ +E  P+ TLP    +  DS
Sbjct: 517 ------SLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDS 558


>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
           sapiens]
          Length = 1188

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 139/604 (23%), Positives = 188/604 (31%), Gaps = 90/604 (14%)

Query: 4   PGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQR 63
           P   G    P      P G G P P   +  P P P+ L     P + PPP P L AL  
Sbjct: 141 PPPPGPAPGPPQDISEPPG-GSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199

Query: 64  PQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSV 123
           P  L                P+      P P     P        +      R      V
Sbjct: 200 PHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTV----GTRLFPPGGV 255

Query: 124 VKQKLAEVILKKQQAALERTVHPNSPGIPY-RTLEPLETEGATRSMLSSFLPPVPSLPSD 182
            K K ++V L  +QA   R   P SP  P    L P      T        PP P     
Sbjct: 256 TKWK-SDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPV---- 310

Query: 183 PPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSS 242
                   +T S P  + +  P+K     K    R    PPS   RPA     S      
Sbjct: 311 --------RTSSIPVQEAQEAPRKEEGATKKAPSRL-PLPPSFHIRPA-----SQVYPDR 356

Query: 243 TPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLP--AP 300
            P   C     +    +P LG         R      AP   P    LP     LP  AP
Sbjct: 357 APEPDCPGELKATAPASPRLGQSQSQADE-RAGTPPPAPPLPPPAPPLPPPAPPLPPAAP 415

Query: 301 ARADSDRRTHPTLG-PRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSG---- 355
               + +  HP  G  + P      +P   P    P    T  S   P+   DPS     
Sbjct: 416 PLPCAQKAAHPPAGFTKTP---KSSSPALKPKPNPPSPENTASS--APVDWRDPSQMEKL 470

Query: 356 ------------------SHAPLLTVP------GLGP----------LPFHFAQSLMTTE 381
                             SH P  TV         GP          LP       +  +
Sbjct: 471 RNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEK 530

Query: 382 RLSGSGLHWPLSRTRSEPLP----PSATAPPPPGPMQPRLEQLKTHVQV-IKRSAKPSEK 436
            L GS L      T +E  P    PS    P   P  P + Q++  ++  +  +A+   K
Sbjct: 531 SLGGSSL------TETEAAPSLTLPSVDYIPQDSP-TPSVRQIRNELEARLSSAAEKEAK 583

Query: 437 PRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLA 496
           P +  +P    LE      G++ ++G +  +L     +   P      P   L  +  L 
Sbjct: 584 PSIGSLPPKPRLE-----GGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLG 638

Query: 497 GRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAP-ASLSAPEPASQARVLSSSETPARTL 555
             +P  +T +  + P A        +A   PA P  + S P    +A    +  + A TL
Sbjct: 639 PAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTL 698

Query: 556 PFTT 559
           P TT
Sbjct: 699 PTTT 702



 Score = 34.7 bits (78), Expect = 0.46
 Identities = 89/408 (21%), Positives = 131/408 (32%), Gaps = 77/408 (18%)

Query: 172 FLPPVPSL----PSDPPEHFPLRKTVSEPN-LKLRYKPKKSLERRKNPLLRKESAPPSLR 226
           F+PP P L    P  PP   P     + P+ +  R  P   + + K+ +        +L 
Sbjct: 214 FIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDV--------ALN 265

Query: 227 RRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPT 286
            R AE    S P S + P      PN   H   P              +   V P     
Sbjct: 266 GRQAEATRASPPRSPAEPKGSALGPNPEPHLTFP--------------RSFKVPPPTPVR 311

Query: 287 VSLLPAITLGLPAPARADSDRRTHPTLGPRGPILG-SPHTPLFLPHGLEPEAGGTLPSRL 345
            S +P +     AP + +   +  P+  P  P     P + ++     EP+  G L +  
Sbjct: 312 TSSIP-VQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKAT- 369

Query: 346 QPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSAT 405
                       AP    P LG       QS    +  +G+    P     + PLPP A 
Sbjct: 370 ------------AP--ASPRLG-------QSQSQADERAGTPPPAPPLPPPAPPLPPPAP 408

Query: 406 APPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIP-------SAEDLETDGGGPGQV 458
             PP  P  P   Q   H          S  P L+  P       +A     D   P Q+
Sbjct: 409 PLPPAAPPLP-CAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQM 467

Query: 459 VDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHR 518
             + L +    +     R    L   P   +  Q +   + PR    +T+L         
Sbjct: 468 --EKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLL--------- 516

Query: 519 PLSRAQSSPAAPASLSAPEPASQARVLSSSE-TPARTLPFTTGLIYDS 565
                 S PA       PE +     L+ +E  P+ TLP    +  DS
Sbjct: 517 ------SLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDS 558


>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
          Length = 1332

 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 108/422 (25%), Positives = 148/422 (35%), Gaps = 78/422 (18%)

Query: 158 PLETEGATRSMLSSFLPPV-PSLPSDPPEHFPLRKTVS-------------EPNLKLRYK 203
           PL  E    S+ SS LP   P LP     H PLR   S             +P  +  +K
Sbjct: 547 PLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPPPRKYFK 606

Query: 204 ----PKKSLERRKNPLLRKESAPPSLRRRPAETL-----GDSSPSSSSTPASGCSSPNDS 254
               P+KSLE R+N        PP+  +   E L      + +   S + ++GC  P   
Sbjct: 607 SDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGCPGPG-- 664

Query: 255 EHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLG 314
             GP     +E   G R     T  +P   P +     +       A     R +     
Sbjct: 665 -IGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDCIKN 723

Query: 315 PRGPILGSPHTPLFL-PHGLEPEAGGTL--PSRLQPIL-------LLDPSGSHAPLLTVP 364
              PI+   H  + L P+    E  GT   P    P L        +  S   + +   P
Sbjct: 724 LFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVKKGP 783

Query: 365 GLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHV 424
            + P P  F QSL         GL    S  R  P P  +T P P        E L +H+
Sbjct: 784 PVAPKPAWFRQSL--------KGLRNRASDPRGLPDPALSTQPAPAS-----REHLGSHI 830

Query: 425 QVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQH 484
           +     A  S     ++I S E       G  Q+ D G +   L     EA    PL +H
Sbjct: 831 R-----ASSSSSSIRQRISSFETF-----GSSQLPDKGAQRLSLQPSSGEA--AKPLGKH 878

Query: 485 PQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAA-----PASLSAPEPA 539
                 E+ R +G L RG+     L+P  Q   + LS    SPAA     P    +P P 
Sbjct: 879 ------EEGRFSGLLGRGAA--PTLVP--QQPEQVLS--SGSPAASEARDPGVSESPPPG 926

Query: 540 SQ 541
            Q
Sbjct: 927 RQ 928


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,513,139
Number of Sequences: 37866
Number of extensions: 2917863
Number of successful extensions: 22002
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 641
Number of HSP's that attempted gapping in prelim test: 17890
Number of HSP's gapped (non-prelim): 4020
length of query: 991
length of database: 18,247,518
effective HSP length: 112
effective length of query: 879
effective length of database: 14,006,526
effective search space: 12311736354
effective search space used: 12311736354
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.