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Search of human proteins with 157671927
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157671927 spermatogenesis associated 5 [Homo sapiens]
(893 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157671927 spermatogenesis associated 5 [Homo sapiens] 1740 0.0
gi|6005942 valosin-containing protein [Homo sapiens] 539 e-153
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens] 447 e-125
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens] 447 e-125
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens] 442 e-124
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens] 271 2e-72
gi|4505725 peroxin1 [Homo sapiens] 268 1e-71
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ... 223 6e-58
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi... 223 6e-58
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens] 223 6e-58
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens] 221 2e-57
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens] 210 5e-54
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens] 204 2e-52
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens] 204 2e-52
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens] 203 5e-52
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens] 200 6e-51
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens] 193 5e-49
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens] 181 4e-45
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens] 181 4e-45
gi|40806170 spastin isoform 2 [Homo sapiens] 178 2e-44
gi|11875211 spastin isoform 1 [Homo sapiens] 178 2e-44
gi|31742536 fidgetin-like 1 [Homo sapiens] 177 5e-44
gi|112789543 fidgetin-like 1 [Homo sapiens] 177 5e-44
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens] 173 6e-43
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens] 173 6e-43
gi|5901990 katanin p60 subunit A 1 [Homo sapiens] 173 7e-43
gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens] 168 2e-41
gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens] 168 2e-41
gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo sap... 168 2e-41
gi|156564401 vesicle-fusing ATPase [Homo sapiens] 167 5e-41
>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
Length = 893
Score = 1740 bits (4506), Expect = 0.0
Identities = 893/893 (100%), Positives = 893/893 (100%)
Query: 1 MSSKKNRKRLNQSAENGSSLPSAASSCAEARAPSAGSDFAATSGTLTVTNLLEKVDDKIP 60
MSSKKNRKRLNQSAENGSSLPSAASSCAEARAPSAGSDFAATSGTLTVTNLLEKVDDKIP
Sbjct: 1 MSSKKNRKRLNQSAENGSSLPSAASSCAEARAPSAGSDFAATSGTLTVTNLLEKVDDKIP 60
Query: 61 KTFQNSLIHLGLNTMKSANICIGRPVLLTSLNGKQEVYTAWPMAGFPGGKVGLSEMAQKN 120
KTFQNSLIHLGLNTMKSANICIGRPVLLTSLNGKQEVYTAWPMAGFPGGKVGLSEMAQKN
Sbjct: 61 KTFQNSLIHLGLNTMKSANICIGRPVLLTSLNGKQEVYTAWPMAGFPGGKVGLSEMAQKN 120
Query: 121 VGVRPGDAIQVQPLVGAVLQAEEMDVALSDKDMEINEEELTGCILRKLDGKIVLPGNFLY 180
VGVRPGDAIQVQPLVGAVLQAEEMDVALSDKDMEINEEELTGCILRKLDGKIVLPGNFLY
Sbjct: 121 VGVRPGDAIQVQPLVGAVLQAEEMDVALSDKDMEINEEELTGCILRKLDGKIVLPGNFLY 180
Query: 181 CTFYGRPYKLQVLRVKGADGMILGGPQSDSDTDAQRMAFEQSSMETSSLELSLQLSQLDL 240
CTFYGRPYKLQVLRVKGADGMILGGPQSDSDTDAQRMAFEQSSMETSSLELSLQLSQLDL
Sbjct: 181 CTFYGRPYKLQVLRVKGADGMILGGPQSDSDTDAQRMAFEQSSMETSSLELSLQLSQLDL 240
Query: 241 EDTQIPTSRSTPYKPIDDRITNKASDVLLDVTQSPGDGSGLMLEEVTGLKCNFESAREGN 300
EDTQIPTSRSTPYKPIDDRITNKASDVLLDVTQSPGDGSGLMLEEVTGLKCNFESAREGN
Sbjct: 241 EDTQIPTSRSTPYKPIDDRITNKASDVLLDVTQSPGDGSGLMLEEVTGLKCNFESAREGN 300
Query: 301 EQLTEEERLLKFSIGAKCNTDTFYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSS 360
EQLTEEERLLKFSIGAKCNTDTFYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSS
Sbjct: 301 EQLTEEERLLKFSIGAKCNTDTFYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSS 360
Query: 361 QLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVING 420
QLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVING
Sbjct: 361 QLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVING 420
Query: 421 PEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTL 480
PEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTL
Sbjct: 421 PEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTL 480
Query: 481 MDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRV 540
MDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRV
Sbjct: 481 MDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRV 540
Query: 541 PHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLK 600
PHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLK
Sbjct: 541 PHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLK 600
Query: 601 DFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQP 660
DFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQP
Sbjct: 601 DFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQP 660
Query: 661 PKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVA 720
PKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVA
Sbjct: 661 PKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVA 720
Query: 721 PSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDK 780
PSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDK
Sbjct: 721 PSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDK 780
Query: 781 ALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVC 840
ALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVC
Sbjct: 781 ALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVC 840
Query: 841 REAALLALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYEDYQEKSGLHTL 893
REAALLALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYEDYQEKSGLHTL
Sbjct: 841 REAALLALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYEDYQEKSGLHTL 893
>gi|6005942 valosin-containing protein [Homo sapiens]
Length = 806
Score = 539 bits (1389), Expect = e-153
Identities = 266/526 (50%), Positives = 374/526 (71%), Gaps = 8/526 (1%)
Query: 339 KNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGT 398
K E+++ +V YD IGG QL I+E++ELPL+ P LFK+ G+ PRG+LLYGPPGT
Sbjct: 190 KREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGT 249
Query: 399 GKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDAL 458
GKT+IARAVANE GA+ +INGPEI+SK GE+E+ LR+ F EA P+IIFIDELDA+
Sbjct: 250 GKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAI 309
Query: 459 CPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKE 518
PKRE EVE+R+V+ LLTLMDG+ V+V+ ATNRP+++D ALRR GRFD+E
Sbjct: 310 APKREKTHGEVERRIVSQLLTLMDGLKQRA---HVIVMAATNRPNSIDPALRRFGRFDRE 366
Query: 519 IEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRR 578
++IG+P+A RL+ILQ + + L + +L Q+AN HG+VGADL LC+EA L A+R+
Sbjct: 367 VDIGIPDATGRLEILQIHTKNMK-LADDVDLEQVANETHGHVGADLAALCSEAALQAIRK 425
Query: 579 ---ILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESI 635
++ + D +V + +T+ DF A++ PSA+RE ++VP V+W DIGGLE +
Sbjct: 426 KMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDV 485
Query: 636 KLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGP 695
K +L++ V++P++HP+ F++ G+ P KGVL YGPPGC KT++AKA+ANE NF++IKGP
Sbjct: 486 KRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGP 545
Query: 696 ELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLG-AGNVADRVLAQLL 754
EL+ + GESE VRE F KAR AP ++FFDELD++A RG ++G G ADRV+ Q+L
Sbjct: 546 ELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQIL 605
Query: 755 TEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMP 814
TEMDG+ K+V I+ ATNRPD ID A++RPGR+D++IY+PLPD +R I K P
Sbjct: 606 TEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSP 665
Query: 815 VSNEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANLIMKR 860
V+ +VDL+ L T+ +SGA++ +C+ A LA+ E I++ + +R
Sbjct: 666 VAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRER 711
>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
Length = 750
Score = 447 bits (1149), Expect = e-125
Identities = 252/611 (41%), Positives = 375/611 (61%), Gaps = 65/611 (10%)
Query: 337 IDKNSKEQDNQFKVT---YDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLY 393
+ K +K + +F+++ ++ +GG LK + +++ + ++ PE++ G+ PRGVLL+
Sbjct: 140 LQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLH 198
Query: 394 GPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFID 453
GPPG GKT++A A+A E+ + + PEI+S GE+E KLR++F +A P IIFID
Sbjct: 199 GPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFID 258
Query: 454 ELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPG 513
E+DA+ PKRE A ++E+R+VA LLT MD + + + +VLV+GATNRP +LD ALRR G
Sbjct: 259 EIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAG 318
Query: 514 RFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGL 573
RFD+EI +G+P+ R ILQ L R++ L + LA+ G+VGADL LC EA +
Sbjct: 319 RFDREICLGIPDEASRERILQTLCRKL-RLPQAFDFCHLAHLTPGFVGADLMALCREAAM 377
Query: 574 CALRRIL-------KKQPNLPDV-----------------------KVAGLVK------- 596
CA+ R+L KK P + D+ ++ GL++
Sbjct: 378 CAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSE 437
Query: 597 -------ITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKH 649
I L DF+ A++ ++PSA RE + VPNV+W+DIG LE I+ +L A+ P+++
Sbjct: 438 EQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRN 497
Query: 650 PESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAV 709
P+ F +G+ P GVLL GPPGC KT++AKA+ANESGLNF+++KGPEL+N YVGESERAV
Sbjct: 498 PDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAV 557
Query: 710 RETFRKARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTIL 769
R+ F++A+ AP +IFFDE+DAL R +V RV+ QLLTEMDG+E + V I+
Sbjct: 558 RQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASV--RVVNQLLTEMDGLEARQQVFIM 615
Query: 770 AATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKL---QFHSMPVSNEVDLDELI- 825
AATNRPD ID A++RPGR+D+ ++V LP A R I K P+ +V+L+ +
Sbjct: 616 AATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAG 675
Query: 826 -LQTDAYSGAEIVAVCREAALLALEEDIQAN---------LIMKRHFTQALSTVTPRIPE 875
L+ D Y+GA++ A+ REA++ AL +++ + +HF +A V I +
Sbjct: 676 DLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISK 735
Query: 876 SLRRFYEDYQE 886
+ YE QE
Sbjct: 736 KDQIMYERLQE 746
>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
Length = 856
Score = 447 bits (1149), Expect = e-125
Identities = 252/611 (41%), Positives = 375/611 (61%), Gaps = 65/611 (10%)
Query: 337 IDKNSKEQDNQFKVT---YDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLY 393
+ K +K + +F+++ ++ +GG LK + +++ + ++ PE++ G+ PRGVLL+
Sbjct: 246 LQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLH 304
Query: 394 GPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFID 453
GPPG GKT++A A+A E+ + + PEI+S GE+E KLR++F +A P IIFID
Sbjct: 305 GPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFID 364
Query: 454 ELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPG 513
E+DA+ PKRE A ++E+R+VA LLT MD + + + +VLV+GATNRP +LD ALRR G
Sbjct: 365 EIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAG 424
Query: 514 RFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGL 573
RFD+EI +G+P+ R ILQ L R++ L + LA+ G+VGADL LC EA +
Sbjct: 425 RFDREICLGIPDEASRERILQTLCRKL-RLPQAFDFCHLAHLTPGFVGADLMALCREAAM 483
Query: 574 CALRRIL-------KKQPNLPDV-----------------------KVAGLVK------- 596
CA+ R+L KK P + D+ ++ GL++
Sbjct: 484 CAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSE 543
Query: 597 -------ITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKH 649
I L DF+ A++ ++PSA RE + VPNV+W+DIG LE I+ +L A+ P+++
Sbjct: 544 EQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRN 603
Query: 650 PESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAV 709
P+ F +G+ P GVLL GPPGC KT++AKA+ANESGLNF+++KGPEL+N YVGESERAV
Sbjct: 604 PDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAV 663
Query: 710 RETFRKARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTIL 769
R+ F++A+ AP +IFFDE+DAL R +V RV+ QLLTEMDG+E + V I+
Sbjct: 664 RQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASV--RVVNQLLTEMDGLEARQQVFIM 721
Query: 770 AATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKL---QFHSMPVSNEVDLDELI- 825
AATNRPD ID A++RPGR+D+ ++V LP A R I K P+ +V+L+ +
Sbjct: 722 AATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAG 781
Query: 826 -LQTDAYSGAEIVAVCREAALLALEEDIQAN---------LIMKRHFTQALSTVTPRIPE 875
L+ D Y+GA++ A+ REA++ AL +++ + +HF +A V I +
Sbjct: 782 DLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISK 841
Query: 876 SLRRFYEDYQE 886
+ YE QE
Sbjct: 842 KDQIMYERLQE 852
>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
Length = 753
Score = 442 bits (1137), Expect = e-124
Identities = 241/560 (43%), Positives = 348/560 (62%), Gaps = 40/560 (7%)
Query: 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAY 414
+GGLS ++RE++ LPL+ P + G+ PRGVLL GPPG GKT + RAVA E GA
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAE 261
Query: 415 VSVINGPEIISKFYGETEAKLRQIFAEA---TLRHPSIIFIDELDALCPKREGAQNEVEK 471
+ ++ P + GETE +R++F A R PS++F+DE+DALCP+R E
Sbjct: 262 LLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQR--GSRAPES 319
Query: 472 RVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLD 531
RVVA +LTL+DG + +V+V+GATNRP ALD ALRRPGRFD+E+ IG P + R +
Sbjct: 320 RVVAQVLTLLDGASGD---REVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKE 376
Query: 532 ILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDVKV 591
ILQ + ++P + + +L LA GYVGADL LC EA + AL K Q N ++
Sbjct: 377 ILQVITSKMP-ISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQDNPVIDEI 435
Query: 592 AGLVKITLKDFLQAMNDIRPSAMREIA--IDVPNVSWSDIGGLESIKLKLEQAVEWPLKH 649
DFL+A +I+PS+ R + +D+ V W +IGGLE +KLKL+Q++EWPLK
Sbjct: 436 ---------DFLEAFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKF 486
Query: 650 PESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAV 709
P F+RMG+ PKGVLLYGPPGC+KT + +ALA +F+++ G +L + +VG+SE+ +
Sbjct: 487 PWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVL 546
Query: 710 RETFRKARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQL------ 763
+ FR+ARA P+I+F DE+D++ R +S +V +RVL+ LL E+DG+
Sbjct: 547 SQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRG 606
Query: 764 -------------KDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKLQF 810
+ V I+AATNRPD +D AL+RPGR+D+IIY+P PD R I K+
Sbjct: 607 SKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCT 666
Query: 811 HSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEED-IQANLIMKRHFTQALSTV 869
+MP+ +V L+ L +T +SGA++ +C EAALLAL+E+ + A + + HF ++L TV
Sbjct: 667 KTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTV 726
Query: 870 TPRIPESLRRFYEDYQEKSG 889
P + YE+ +K G
Sbjct: 727 KPSLSCKDLALYENLFKKEG 746
Score = 157 bits (396), Expect = 5e-38
Identities = 101/283 (35%), Positives = 151/283 (53%), Gaps = 34/283 (12%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409
V ++ IGGL +++ IE PLK P F G+ P+GVLLYGPPG KT + RA+A
Sbjct: 461 VDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALAT 520
Query: 410 EVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQN-- 467
++G ++ S F G++E L QIF +A P+I+F+DE+D++ R ++
Sbjct: 521 SCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGC 580
Query: 468 EVEKRVVASLLTLMDGIG----------------SEVSEGQVLVLGATNRPHALDAALRR 511
+V++RV++ LL +DG+G EV V+++ ATNRP LD AL R
Sbjct: 581 DVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLR 640
Query: 512 PGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEA 571
PGR DK I I P+ + RL IL+ + +P + + L LA + GADL+ LC EA
Sbjct: 641 PGRLDKIIYIPPPDHKGRLSILKVCTKTMP-IGPDVSLENLAAETCFFSGADLRNLCTEA 699
Query: 572 GLCALRRILKKQPNLPDVKVAGLVKITLKD--FLQAMNDIRPS 612
L AL+ GL T+K FL+++ ++PS
Sbjct: 700 ALLALQE-------------NGLDATTVKQEHFLKSLKTVKPS 729
>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
Length = 980
Score = 271 bits (694), Expect = 2e-72
Identities = 177/519 (34%), Positives = 281/519 (54%), Gaps = 29/519 (5%)
Query: 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSI 449
VLL GPPG GKT + A + +G ++ + + ++ G E KL+ IF+ A P++
Sbjct: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
Query: 450 IFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAAL 509
+ + +D L R+G + RV+A L L+ S ++V+ T+R L A +
Sbjct: 526 LLLTAVDLLGRDRDGLGEDA--RVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADV 583
Query: 510 RRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCN 569
+ F E+E+ + RL IL+ L +P L E L QLA G+V DL L
Sbjct: 584 QTA--FPHELEVPALSEGQRLSILRALTAHLP-LGQEVNLAQLARRCAGFVVGDLYALLT 640
Query: 570 EAGLCALRRILKK-------QPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREI-AIDV 621
+ A RI + + ++ AG + +DF QA+ ++ + + + A +
Sbjct: 641 HSSRAACTRIKNSGLAGGLTEEDEGELCAAGF-PLLAEDFGQALEQLQTAHSQAVGAPKI 699
Query: 622 PNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKAL 681
P+VSW D+GGL+ +K ++ + ++ PL+HPE + +G++ G+LL+GPPG KT++AKA+
Sbjct: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPE-LLSLGLRR-SGLLLHGPPGTGKTLLAKAV 757
Query: 682 ANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLG 741
A E L FL++KGPEL+N YVG+SE VRE F +ARA AP IIFFDELD+LA RG S
Sbjct: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGD 817
Query: 742 AGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPL-PDAA 800
+G V DRV++QLL E+DG+ +DV ++ ATNRPD +D AL+RPGR D++++V D A
Sbjct: 818 SGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRA 877
Query: 801 TRREIFKLQFHSMPVSNEVDL-DELILQTDAYSGAEIVAVCREAALLALEEDI------- 852
++ + + V L + L +GA++ ++C +A AL+ +
Sbjct: 878 SQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGL 937
Query: 853 ----QANLIMKRHFTQALSTVTPRIPESLRRFYEDYQEK 887
A ++ QA + + P + E Y+ Q K
Sbjct: 938 EPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRK 976
Score = 160 bits (404), Expect = 6e-39
Identities = 108/272 (39%), Positives = 155/272 (56%), Gaps = 13/272 (4%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409
V++ +GGL K I E I+LPL+ PEL S G+ G+LL+GPPGTGKT++A+AVA
Sbjct: 702 VSWHDVGGLQEVKKEILETIQLPLEHPELL-SLGLRRS-GLLLHGPPGTGKTLLAKAVAT 759
Query: 410 EVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPK--REGAQN 467
E + GPE+I+ + G++E +R++FA A P IIF DELD+L P R G
Sbjct: 760 ECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSG 819
Query: 468 EVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGV-PNA 526
V RVV+ LL +DG+ S V V+GATNRP LD AL RPGRFDK + +G +
Sbjct: 820 GVMDRVVSQLLAELDGLH---STQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDR 876
Query: 527 QDRLDILQKLLRRVPHLLTEAELLQLANSAHGYV-GADLKVLCNEAGLCAL-RRILKKQP 584
+L +L + R+ L L+ + + + GADL LC++A AL RR+ +
Sbjct: 877 ASQLRVLSAITRKF-KLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEE 935
Query: 585 NLPDVKVAGLVKITLKDFLQAMNDIRPSAMRE 616
L A + +T++D LQA ++PS +
Sbjct: 936 GLEPGSSA--LMLTMEDLLQAAARLQPSVSEQ 965
>gi|4505725 peroxin1 [Homo sapiens]
Length = 1283
Score = 268 bits (686), Expect = 1e-71
Identities = 163/477 (34%), Positives = 268/477 (56%), Gaps = 30/477 (6%)
Query: 390 VLLYGPPGTGKTMIARAVANE----VGAYVSVINGPEIISKFYGETEAKLRQIFAEATLR 445
+LL G G+GK+ +A+A+ E + A+V ++ + K + L F+EA
Sbjct: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWM 654
Query: 446 HPSIIFIDELDALC-----PKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATN 500
PS++ +D+LD + P+ E + + V+ + +A L D I +S G ++ L AT+
Sbjct: 655 QPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALN--DMIKEFISMGSLVALIATS 712
Query: 501 RP----HALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVP----HLLTEAELLQL 552
+ H L + + F I PN + R +IL +++ + T+ +L +
Sbjct: 713 QSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHV 772
Query: 553 ANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPS 612
A G+V D VL + A L R + + +T DF +A+ P+
Sbjct: 773 AKETGGFVARDFTVLVDRAIHSRLSR--------QSISTREKLVLTTLDFQKALRGFLPA 824
Query: 613 AMREIAIDVP-NVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPG 671
++R + + P ++ W IGGL ++ L ++ P K+PE F + I+ G+LLYGPPG
Sbjct: 825 SLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPG 884
Query: 672 CSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDA 731
KT++A +A ES +NF+++KGPEL++KY+G SE+AVR+ F +A+A P I+FFDE ++
Sbjct: 885 TGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFES 944
Query: 732 LAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRI 791
+A RG V DRV+ QLLT++DG+E L+ V +LAAT+RPD ID AL+RPGR+D+
Sbjct: 945 IAPRRGHD--NTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKC 1002
Query: 792 IYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLAL 848
+Y P PD +R EI + S+P++++VDL + TD+++GA++ A+ A L AL
Sbjct: 1003 VYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059
Score = 159 bits (402), Expect = 1e-38
Identities = 95/229 (41%), Positives = 131/229 (57%), Gaps = 4/229 (1%)
Query: 352 YDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEV 411
+D IGGL + + + I+LP K PELF + I G+LLYGPPGTGKT++A +A E
Sbjct: 839 WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898
Query: 412 GAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEK 471
+ GPE++SK+ G +E +R IF A P I+F DE +++ P+R V
Sbjct: 899 RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTD 958
Query: 472 RVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLD 531
RVV LLT +DG+ E +G V VL AT+RP +D AL RPGR DK + P+ RL+
Sbjct: 959 RVVNQLLTQLDGV--EGLQG-VYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLE 1015
Query: 532 ILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRIL 580
IL L +P L + +L +A+ + GADLK L A L AL +L
Sbjct: 1016 ILNVLSDSLP-LADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGML 1063
>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
[Homo sapiens]
Length = 414
Score = 223 bits (568), Expect = 6e-58
Identities = 120/292 (41%), Positives = 183/292 (62%), Gaps = 9/292 (3%)
Query: 597 ITLKDFLQAMNDIRP-----SAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPE 651
+ L A+ D+ P S M + P+V ++DIGG++ K ++ +AVE PL H E
Sbjct: 126 VALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFE 185
Query: 652 SFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRE 711
+ ++GI PP+GVL+YGPPGC KTM+AKA+A+ + F+ + G E + KY+GE R VR+
Sbjct: 186 LYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRD 245
Query: 712 TFRKARAVAPSIIFFDELDALAVER-GSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILA 770
FR A+ AP+IIF DE+DA+A +R + GA R+L +LL +MDG +Q +V ++
Sbjct: 246 VFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIM 305
Query: 771 ATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDA 830
ATNR D +D AL+RPGR+DR I PLPD +R IF M +S EVDL++ + + D
Sbjct: 306 ATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDK 365
Query: 831 YSGAEIVAVCREAALLALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYE 882
SGA+I ++C+E+ +LA+ E+ +++ + F +A TV + E FY+
Sbjct: 366 ISGADINSICQESGMLAVREN--RYIVLAKDFEKAYKTVIKK-DEQEHEFYK 414
Score = 162 bits (410), Expect = 1e-39
Identities = 97/237 (40%), Positives = 136/237 (57%), Gaps = 9/237 (3%)
Query: 345 DNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIA 404
D + V Y IGG+ Q + +RE +ELPL EL+K GI PRGVL+YGPPG GKTM+A
Sbjct: 153 DQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLA 212
Query: 405 RAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR-- 462
+AVA+ A + G E + K+ GE +R +F A P+IIFIDE+DA+ KR
Sbjct: 213 KAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD 272
Query: 463 --EGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIE 520
GA EV+ R++ LL MDG V+ V V+ ATNR LD AL RPGR D++IE
Sbjct: 273 AQTGADREVQ-RILLELLNQMDGFDQNVN---VKVIMATNRADTLDPALLRPGRLDRKIE 328
Query: 521 IGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALR 577
+P+ + + I + ++ +L E +L GAD+ +C E+G+ A+R
Sbjct: 329 FPLPDRRQKRLIFSTITSKM-NLSEEVDLEDYVARPDKISGADINSICQESGMLAVR 384
>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
sapiens]
Length = 387
Score = 223 bits (568), Expect = 6e-58
Identities = 120/292 (41%), Positives = 183/292 (62%), Gaps = 9/292 (3%)
Query: 597 ITLKDFLQAMNDIRP-----SAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPE 651
+ L A+ D+ P S M + P+V ++DIGG++ K ++ +AVE PL H E
Sbjct: 99 VALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFE 158
Query: 652 SFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRE 711
+ ++GI PP+GVL+YGPPGC KTM+AKA+A+ + F+ + G E + KY+GE R VR+
Sbjct: 159 LYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRD 218
Query: 712 TFRKARAVAPSIIFFDELDALAVER-GSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILA 770
FR A+ AP+IIF DE+DA+A +R + GA R+L +LL +MDG +Q +V ++
Sbjct: 219 VFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIM 278
Query: 771 ATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDA 830
ATNR D +D AL+RPGR+DR I PLPD +R IF M +S EVDL++ + + D
Sbjct: 279 ATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDK 338
Query: 831 YSGAEIVAVCREAALLALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYE 882
SGA+I ++C+E+ +LA+ E+ +++ + F +A TV + E FY+
Sbjct: 339 ISGADINSICQESGMLAVREN--RYIVLAKDFEKAYKTVIKK-DEQEHEFYK 387
Score = 162 bits (410), Expect = 1e-39
Identities = 97/237 (40%), Positives = 136/237 (57%), Gaps = 9/237 (3%)
Query: 345 DNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIA 404
D + V Y IGG+ Q + +RE +ELPL EL+K GI PRGVL+YGPPG GKTM+A
Sbjct: 126 DQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLA 185
Query: 405 RAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR-- 462
+AVA+ A + G E + K+ GE +R +F A P+IIFIDE+DA+ KR
Sbjct: 186 KAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD 245
Query: 463 --EGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIE 520
GA EV+ R++ LL MDG V+ V V+ ATNR LD AL RPGR D++IE
Sbjct: 246 AQTGADREVQ-RILLELLNQMDGFDQNVN---VKVIMATNRADTLDPALLRPGRLDRKIE 301
Query: 521 IGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALR 577
+P+ + + I + ++ +L E +L GAD+ +C E+G+ A+R
Sbjct: 302 FPLPDRRQKRLIFSTITSKM-NLSEEVDLEDYVARPDKISGADINSICQESGMLAVR 357
>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
Length = 418
Score = 223 bits (568), Expect = 6e-58
Identities = 120/292 (41%), Positives = 183/292 (62%), Gaps = 9/292 (3%)
Query: 597 ITLKDFLQAMNDIRP-----SAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPE 651
+ L A+ D+ P S M + P+V ++DIGG++ K ++ +AVE PL H E
Sbjct: 130 VALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFE 189
Query: 652 SFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRE 711
+ ++GI PP+GVL+YGPPGC KTM+AKA+A+ + F+ + G E + KY+GE R VR+
Sbjct: 190 LYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRD 249
Query: 712 TFRKARAVAPSIIFFDELDALAVER-GSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILA 770
FR A+ AP+IIF DE+DA+A +R + GA R+L +LL +MDG +Q +V ++
Sbjct: 250 VFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIM 309
Query: 771 ATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDA 830
ATNR D +D AL+RPGR+DR I PLPD +R IF M +S EVDL++ + + D
Sbjct: 310 ATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDK 369
Query: 831 YSGAEIVAVCREAALLALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYE 882
SGA+I ++C+E+ +LA+ E+ +++ + F +A TV + E FY+
Sbjct: 370 ISGADINSICQESGMLAVREN--RYIVLAKDFEKAYKTVIKK-DEQEHEFYK 418
Score = 162 bits (410), Expect = 1e-39
Identities = 97/237 (40%), Positives = 136/237 (57%), Gaps = 9/237 (3%)
Query: 345 DNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIA 404
D + V Y IGG+ Q + +RE +ELPL EL+K GI PRGVL+YGPPG GKTM+A
Sbjct: 157 DQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLA 216
Query: 405 RAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR-- 462
+AVA+ A + G E + K+ GE +R +F A P+IIFIDE+DA+ KR
Sbjct: 217 KAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD 276
Query: 463 --EGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIE 520
GA EV+ R++ LL MDG V+ V V+ ATNR LD AL RPGR D++IE
Sbjct: 277 AQTGADREVQ-RILLELLNQMDGFDQNVN---VKVIMATNRADTLDPALLRPGRLDRKIE 332
Query: 521 IGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALR 577
+P+ + + I + ++ +L E +L GAD+ +C E+G+ A+R
Sbjct: 333 FPLPDRRQKRLIFSTITSKM-NLSEEVDLEDYVARPDKISGADINSICQESGMLAVR 388
>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
Length = 440
Score = 221 bits (563), Expect = 2e-57
Identities = 111/246 (45%), Positives = 163/246 (66%), Gaps = 1/246 (0%)
Query: 606 MNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVL 665
M+D P P +++DIGGL++ +++++VE PL HPE + MGI+PPKGV+
Sbjct: 164 MDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVI 223
Query: 666 LYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIF 725
LYGPPG KT++AKA+AN++ FL + G EL+ KY+G+ + VRE FR A APSI+F
Sbjct: 224 LYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVF 283
Query: 726 FDELDALAVER-GSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMR 784
DE+DA+ +R S+ G R + +LL ++DG + DV ++ ATNR + +D AL+R
Sbjct: 284 IDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR 343
Query: 785 PGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAA 844
PGRIDR I PLPD T++ IF++ M ++++V LD+LI+ D SGA+I A+C EA
Sbjct: 344 PGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAG 403
Query: 845 LLALEE 850
L+AL E
Sbjct: 404 LMALRE 409
Score = 176 bits (446), Expect = 9e-44
Identities = 98/235 (41%), Positives = 142/235 (60%), Gaps = 1/235 (0%)
Query: 351 TYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANE 410
TY IGGL +Q++ I+E +ELPL PE ++ GI P+GV+LYGPPGTGKT++A+AVAN+
Sbjct: 183 TYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQ 242
Query: 411 VGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVE 470
A + G E+I K+ G+ +R++F A PSI+FIDE+DA+ KR + + E
Sbjct: 243 TSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGE 302
Query: 471 KRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRL 530
+ + ++L L++ + S G V V+ ATNR LD AL RPGR D++IE +P+ + +
Sbjct: 303 REIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKK 362
Query: 531 DILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPN 585
I Q R+ L + L L + GAD+K +C EAGL ALR K N
Sbjct: 363 RIFQIHTSRMT-LADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTN 416
>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
Length = 1458
Score = 210 bits (534), Expect = 5e-54
Identities = 117/276 (42%), Positives = 172/276 (62%), Gaps = 12/276 (4%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409
V +D IGGLS + A++E++ PL PE+F+ + I PRG L YGPPGTGKT++ARA+AN
Sbjct: 397 VRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 456
Query: 410 EVGAYVSVI-----NGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREG 464
E + G + +SK+ GE+E +LR +F +A L PSIIF DE+D L P R
Sbjct: 457 ECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS 516
Query: 465 AQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVP 524
Q+++ +V++LL LMDG+ + G+++V+GATNR ++D ALRRPGRFD+E +P
Sbjct: 517 RQDQIHSSIVSTLLALMDGLDNR---GEIVVIGATNRLDSIDPALRRPGRFDREFLFNLP 573
Query: 525 NAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRR---ILK 581
+ + R ILQ R L++A L +LA GY GAD+K LC EA L ALRR +
Sbjct: 574 DQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIY 633
Query: 582 KQPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREI 617
+ + V+ +V ++ +DF AM +I P++ R +
Sbjct: 634 ASSHKLQLDVSSIV-LSAQDFYHAMQNIVPASQRAV 668
Score = 171 bits (433), Expect = 3e-42
Identities = 105/271 (38%), Positives = 150/271 (55%), Gaps = 26/271 (9%)
Query: 623 NVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALA 682
+V + IGGL L++ V +PL +PE F + IQPP+G L YGPPG KT++A+ALA
Sbjct: 396 SVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALA 455
Query: 683 NESG-----LNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERG 737
NE + F KG + ++K+VGESER +R F +A + PSIIFFDE+D LA R
Sbjct: 456 NECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRS 515
Query: 738 SSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLP 797
S + +++ LL MDG++ ++ ++ ATNR D ID AL RPGR DR LP
Sbjct: 516 SR--QDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLP 573
Query: 798 DAATRREIFKLQFHSM---PVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEE---- 850
D R+ I LQ H+ P ++ L EL + Y GA+I A+C EAAL+AL
Sbjct: 574 DQKARKHI--LQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQ 631
Query: 851 ----------DIQANLIMKRHFTQALSTVTP 871
D+ + ++ + F A+ + P
Sbjct: 632 IYASSHKLQLDVSSIVLSAQDFYHAMQNIVP 662
>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
Length = 1390
Score = 204 bits (520), Expect = 2e-52
Identities = 113/275 (41%), Positives = 168/275 (61%), Gaps = 10/275 (3%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409
V +D +GGLS+ + A++E++ PL PE+F+ + I PRG L YGPPGTGKT++ARA+AN
Sbjct: 423 VRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 482
Query: 410 EVG-----AYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREG 464
E + G + +SK+ GE+E +LR +F +A PSIIF DE+D L P R
Sbjct: 483 ECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSS 542
Query: 465 AQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVP 524
Q+++ +V++LL LMDG+ S G+++V+GATNR ++D ALRRPGRFD+E +P
Sbjct: 543 RQDQIHSSIVSTLLALMDGLD---SRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLP 599
Query: 525 NAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQP 584
+ + R +IL+ R + L +LA + GY GAD+K +C EA LCALRR +
Sbjct: 600 DKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIY 659
Query: 585 NLPDVKVAGL--VKITLKDFLQAMNDIRPSAMREI 617
+ L + I+ KDF AM + P++ R +
Sbjct: 660 TTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAV 694
Score = 172 bits (436), Expect = 1e-42
Identities = 98/232 (42%), Positives = 137/232 (59%), Gaps = 8/232 (3%)
Query: 623 NVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALA 682
+V + +GGL + L++ V +PL +PE F + IQPP+G L YGPPG KT++A+ALA
Sbjct: 422 SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALA 481
Query: 683 NESG-----LNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERG 737
NE + F KG + ++K+VGESER +R F +A + PSIIFFDE+D LA R
Sbjct: 482 NECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRS 541
Query: 738 SSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLP 797
S + +++ LL MDG++ ++ ++ ATNR D ID AL RPGR DR LP
Sbjct: 542 SR--QDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLP 599
Query: 798 DAATRREIFKLQFHSM-PVSNEVDLDELILQTDAYSGAEIVAVCREAALLAL 848
D R+EI K+ P + L+EL Y GA+I ++C EAAL AL
Sbjct: 600 DKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCAL 651
>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
Length = 403
Score = 204 bits (520), Expect = 2e-52
Identities = 128/370 (34%), Positives = 199/370 (53%), Gaps = 22/370 (5%)
Query: 505 LDAALRRPGRFDKEIEIGVPNAQDRLDILQ---KLLRRVPHLLTEAELLQLANSAHGYVG 561
+D L+ KE+ +++ L LQ +++ V LTE + + A + YV
Sbjct: 36 IDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYV- 94
Query: 562 ADLKVLCNEAGLCALRRILKKQPNLPDVKVA-GLVKITLKDFLQAMNDIRPSAMREIAID 620
RR L K P +VA + +T+ +L ++ P D
Sbjct: 95 ------------VGCRRQLDKSKLKPGTRVALDMTTLTIMRYLP--REVDPLVYNMSHED 140
Query: 621 VPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKA 680
NVS+S+IGGL +L + +E PL +PE F R+GI PPKG LLYGPPG KT++A+A
Sbjct: 141 PGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARA 200
Query: 681 LANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGS-S 739
+A++ NFL + +++KY+GES R +RE F AR P IIF DE+DA+ R S
Sbjct: 201 VASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEG 260
Query: 740 LGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDA 799
A R L +LL +MDG + L V ++ ATNRPD +D AL+RPGR+DR I++ LP+
Sbjct: 261 TSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNE 320
Query: 800 ATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANLIMK 859
R +I K+ + E+D + ++ +D ++GA++ VC EA + A+ D + +++
Sbjct: 321 QARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRAD--HDFVVQ 378
Query: 860 RHFTQALSTV 869
F +A+ V
Sbjct: 379 EDFMKAVRKV 388
Score = 175 bits (443), Expect = 2e-43
Identities = 102/271 (37%), Positives = 156/271 (57%), Gaps = 15/271 (5%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409
V+Y IGGLS Q++ +RE+IELPL PELF+ GI P+G LLYGPPGTGKT++ARAVA+
Sbjct: 144 VSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVAS 203
Query: 410 EVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEV 469
++ + I+ K+ GE+ +R++F A P IIF+DE+DA+ +R
Sbjct: 204 QLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSA 263
Query: 470 EKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDR 529
++ + +L+ L++ + + +V ++ ATNRP LD AL RPGR D++I I +PN Q R
Sbjct: 264 DREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQAR 323
Query: 530 LDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDV 589
LDIL K+ E + + + G+ GADL+ +C EAG+ A+R
Sbjct: 324 LDIL-KIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIR------------ 370
Query: 590 KVAGLVKITLKDFLQAMNDIRPSAMREIAID 620
A + +DF++A+ + S E +D
Sbjct: 371 --ADHDFVVQEDFMKAVRKVADSKKLESKLD 399
>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
Length = 433
Score = 203 bits (517), Expect = 5e-52
Identities = 106/249 (42%), Positives = 152/249 (61%), Gaps = 3/249 (1%)
Query: 622 PNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKAL 681
P+V++SD+GG + KL + VE PL HPE F+ +GI+PPKGVLL+GPPG KT+ A+A+
Sbjct: 170 PDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAV 229
Query: 682 ANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVER-GSSL 740
AN + F+ + G EL+ KYVGE R VRE F AR +IFFDE+DA+ R
Sbjct: 230 ANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGA 289
Query: 741 GAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDAA 800
G N R + +L+ ++DG + ++ +L ATNRPD +D ALMRPGR+DR I LPD
Sbjct: 290 GGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLE 349
Query: 801 TRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANLIMKR 860
R IFK+ SM V ++ + L +GAEI +VC EA + A+ + + ++
Sbjct: 350 GRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIR--ARRKIATEK 407
Query: 861 HFTQALSTV 869
F +A++ V
Sbjct: 408 DFLEAVNKV 416
Score = 167 bits (422), Expect = 5e-41
Identities = 101/264 (38%), Positives = 144/264 (54%), Gaps = 23/264 (8%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409
VTY +GG Q++ +RE++E PL PE F + GI P+GVLL+GPPGTGKT+ ARAVAN
Sbjct: 172 VTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVAN 231
Query: 410 EVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGA 465
A + G E++ K+ GE +R++F A + +IF DE+DA+ R G
Sbjct: 232 RTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGG 291
Query: 466 QNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPN 525
NEV+ R + L+ +DG G + VL ATNRP LD AL RPGR D++IE +P+
Sbjct: 292 DNEVQ-RTMLELINQLDGFD---PRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPD 347
Query: 526 AQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPN 585
+ R I K+ R + + LA GA+++ +C EAG+ A+R K
Sbjct: 348 LEGRTHIF-KIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRK---- 402
Query: 586 LPDVKVAGLVKITLKDFLQAMNDI 609
T KDFL+A+N +
Sbjct: 403 ----------IATEKDFLEAVNKV 416
>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
Length = 439
Score = 200 bits (508), Expect = 6e-51
Identities = 134/409 (32%), Positives = 215/409 (52%), Gaps = 21/409 (5%)
Query: 458 LCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALR----RPG 513
L P E EK DGIG EV + + R LD+ ++
Sbjct: 3 LLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEI--IQRTRLLDSEIKIMKSEVL 60
Query: 514 RFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEA-ELLQLANSAHGYVGADLKVLCNEAG 572
R E++ ++ + + K+ + +P+L++ ELL + + GA++ + G
Sbjct: 61 RVTHELQAMKDKIKENSEKI-KVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKG 119
Query: 573 LCALRRILKKQPN-LPDVKVAGLVKITLKDF----------LQAMNDIRPSAMREIAIDV 621
CA+ + +Q LP + + K+ D L+ + S ++ + +D
Sbjct: 120 KCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDE 179
Query: 622 -PNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKA 680
P +SDIGGL+ +L +A+ P+ H E F +GIQPPKGVL+YGPPG KT++A+A
Sbjct: 180 RPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARA 239
Query: 681 LANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSL 740
A ++ FL + GP+L+ ++G+ + VR+ F A+ APSIIF DELDA+ +R S
Sbjct: 240 CAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSE 299
Query: 741 GAGN-VADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDA 799
AG+ R + +LL ++DG + V ++AATNR D +D AL+R GR+DR I P+P+
Sbjct: 300 KAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNE 359
Query: 800 ATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLAL 848
R I ++ M VS +V+ +EL TD ++GA+ AVC EA ++AL
Sbjct: 360 EARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIAL 408
Score = 169 bits (427), Expect = 1e-41
Identities = 101/281 (35%), Positives = 157/281 (55%), Gaps = 22/281 (7%)
Query: 330 TRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRG 389
+RV E+D+ EQ Y IGGL Q++ + E I LP+ E F++ GI P+G
Sbjct: 170 SRVKAMEVDERPTEQ-------YSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKG 222
Query: 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSI 449
VL+YGPPGTGKT++ARA A + A + GP+++ F G+ +R FA A + PSI
Sbjct: 223 VLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSI 282
Query: 450 IFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAAL 509
IFIDELDA+ KR ++ ++ V ++L L++ + QV V+ ATNR LD AL
Sbjct: 283 IFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPAL 342
Query: 510 RRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCN 569
R GR D++IE +PN + R I+Q R++ ++ + +LA + GA K +C
Sbjct: 343 LRSGRLDRKIEFPMPNEEARARIMQIHSRKM-NVSPDVNYEELARCTDDFNGAQCKAVCV 401
Query: 570 EAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIR 610
EAG+ ALRR G ++T +D+++ + +++
Sbjct: 402 EAGMIALRR--------------GATELTHEDYMEGILEVQ 428
>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
Length = 406
Score = 193 bits (491), Expect = 5e-49
Identities = 112/314 (35%), Positives = 177/314 (56%), Gaps = 12/314 (3%)
Query: 548 ELLQLANSAHGYVGADLKVLCNEAGLCAL----RRILKKQPNLPDVKVAGLVKITLKDFL 603
E LQL YVG ++ + + L + + ++ N+ V ++ L++
Sbjct: 61 EELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDS 120
Query: 604 QAMNDIRPSAMREIAI-----DVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGI 658
++ I P+ + + VP+ ++ IGGL+ ++++ +E P+KHPE F +GI
Sbjct: 121 YTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGI 180
Query: 659 QPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARA 718
PKGVLLYGPPG KT++A+A+A+ + F+ + G EL+ K++GE R VRE F AR
Sbjct: 181 AQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMARE 240
Query: 719 VAPSIIFFDELDALAVER--GSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPD 776
APSIIF DE+D++ R G S G + R + +LL ++DG E K++ ++ ATNR D
Sbjct: 241 HAPSIIFMDEIDSIGSSRLEGGS-GGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRID 299
Query: 777 RIDKALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEI 836
+D AL+RPGRIDR I P P+ R +I K+ M ++ ++L ++ SGAE+
Sbjct: 300 ILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEV 359
Query: 837 VAVCREAALLALEE 850
VC EA + AL E
Sbjct: 360 KGVCTEAGMYALRE 373
Score = 186 bits (473), Expect = 6e-47
Identities = 106/231 (45%), Positives = 148/231 (64%), Gaps = 9/231 (3%)
Query: 351 TYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANE 410
TY+MIGGL Q+K I+E+IELP+K PELF++ GI P+GVLLYGPPGTGKT++ARAVA+
Sbjct: 147 TYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHH 206
Query: 411 VGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQ 466
++G E++ KF GE +R++F A PSIIF+DE+D++ R G
Sbjct: 207 TDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGD 266
Query: 467 NEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNA 526
+EV+ R + LL +DG + + + V+ ATNR LD+AL RPGR D++IE PN
Sbjct: 267 SEVQ-RTMLELLNQLDGFEATKN---IKVIMATNRIDILDSALLRPGRIDRKIEFPPPNE 322
Query: 527 QDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALR 577
+ RLDIL K+ R +L L ++A G GA++K +C EAG+ ALR
Sbjct: 323 EARLDIL-KIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALR 372
>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
Length = 795
Score = 181 bits (458), Expect = 4e-45
Identities = 98/231 (42%), Positives = 145/231 (62%), Gaps = 5/231 (2%)
Query: 624 VSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALAN 683
VS+ D+ G+ KL++ + V++ LK PE F+++G + PKG LL GPPGC KT++AKA+A
Sbjct: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
Query: 684 ESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLG-- 741
E+ + FLA+ GPE + G VR F++ARA AP I++ DE+DA+ +R +++
Sbjct: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
Query: 742 AGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDAAT 801
+ ++ L QLL EMDG+ V +LA+TNR D +D ALMRPGR+DR +++ LP
Sbjct: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
Query: 802 RREIFKLQFHSMPV--SNEVDLDELILQTDAYSGAEIVAVCREAALLALEE 850
RREIF+ S+ + S+ L T +SGA+I +C EAAL A E
Sbjct: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAARE 535
Score = 150 bits (379), Expect = 5e-36
Identities = 90/235 (38%), Positives = 132/235 (56%), Gaps = 13/235 (5%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409
V++ + G+ +RE ++ LK PE F G P+G LL GPPG GKT++A+AVA
Sbjct: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
Query: 410 EVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGA 465
E + GPE + G A++R +F EA R P I++IDE+DA+ KR G
Sbjct: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
Query: 466 QNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPN 525
N E++ + LL MDG+G + V+VL +TNR LD AL RPGR D+ + I +P
Sbjct: 425 SNTEEEQTLNQLLVEMDGMG---TTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPT 481
Query: 526 AQDRLDILQKLLRRVPHLLTEAELL---QLANSAHGYVGADLKVLCNEAGLCALR 577
Q+R +I ++ L+ + LT++ +LA G+ GAD+ +CNEA L A R
Sbjct: 482 LQERREIFEQHLKSLK--LTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAR 534
>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
Length = 797
Score = 181 bits (458), Expect = 4e-45
Identities = 100/255 (39%), Positives = 151/255 (59%), Gaps = 8/255 (3%)
Query: 620 DVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAK 679
D +V + D+ G E KL++ + V + LK+P+ + +G + PKG +L GPPG KT++AK
Sbjct: 301 DEIDVKFKDVAGCEEAKLEIMEFVNF-LKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAK 359
Query: 680 ALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERG-S 738
A A E+ + F+ + G E + +VG VR+ F AR AP I+F DE+DA+ +RG
Sbjct: 360 ATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRG 419
Query: 739 SLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPD 798
+ G + + L QLL EMDG +V ILA TNRPD +D AL+RPGR DR I++ PD
Sbjct: 420 NFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPD 479
Query: 799 AATRREIFKLQFHSMPVSNEVDLDELILQ----TDAYSGAEIVAVCREAALLALEEDIQA 854
R IFK+ + + + ++ D+L + T +SGA++ VC EAAL+A +
Sbjct: 480 IKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARH--LS 537
Query: 855 NLIMKRHFTQALSTV 869
+ I ++HF QA+ V
Sbjct: 538 DSINQKHFEQAIERV 552
Score = 144 bits (364), Expect = 3e-34
Identities = 91/253 (35%), Positives = 139/253 (54%), Gaps = 12/253 (4%)
Query: 334 FTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLY 393
F+ + +K ++ V + + G I E + LK P+ ++ G P+G +L
Sbjct: 289 FSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNF-LKNPKQYQDLGAKIPKGAILT 347
Query: 394 GPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFID 453
GPPGTGKT++A+A A E ++G E + F G A++R +FA A P I+FID
Sbjct: 348 GPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFID 407
Query: 454 ELDALCPKRE----GAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAAL 509
E+DA+ KR G Q+E ++ + LL MDG + + V++L TNRP LD AL
Sbjct: 408 EIDAVGRKRGRGNFGGQSE-QENTLNQLLVEMDGFNTTTN---VVILAGTNRPDILDPAL 463
Query: 510 RRPGRFDKEIEIGVPNAQDRLDILQKLLR--RVPHLLTEAELL-QLANSAHGYVGADLKV 566
RPGRFD++I IG P+ + R I + LR ++ L + +L +LA+ G+ GAD+
Sbjct: 464 LRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVAN 523
Query: 567 LCNEAGLCALRRI 579
+CNEA L A R +
Sbjct: 524 VCNEAALIAARHL 536
>gi|40806170 spastin isoform 2 [Homo sapiens]
Length = 584
Score = 178 bits (452), Expect = 2e-44
Identities = 114/287 (39%), Positives = 166/287 (57%), Gaps = 14/287 (4%)
Query: 333 NFTEIDKN------SKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPA 386
NF +D N ++ DN V +D I G +A++EI+ LP +PELF PA
Sbjct: 284 NFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPA 343
Query: 387 PRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRH 446
RG+LL+GPPG GKTM+A+AVA E A I+ + SK+ GE E +R +FA A
Sbjct: 344 -RGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQ 402
Query: 447 PSIIFIDELDA-LCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHAL 505
PSIIFIDE+D+ LC +REG +++ +R+ L DG+ S + +VLV+GATNRP L
Sbjct: 403 PSIIFIDEVDSLLCERREG-EHDASRRLKTEFLIEFDGVQS-AGDDRVLVMGATNRPQEL 460
Query: 506 DAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLK 565
D A+ R RF K + + +PN + RL +L+ LL + LT+ EL QLA GY G+DL
Sbjct: 461 DEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLT 518
Query: 566 VLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPS 612
L +A L +R + K + ++ + + I L DF +++ I+ S
Sbjct: 519 ALAKDAALGPIREL--KPEQVKNMSASEMRNIRLSDFTESLKKIKRS 563
Score = 153 bits (387), Expect = 6e-37
Identities = 107/307 (34%), Positives = 165/307 (53%), Gaps = 24/307 (7%)
Query: 596 KITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIR 655
K LK+F +++ M EI + V + DI G + K L++ V P PE F
Sbjct: 279 KKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTG 338
Query: 656 MGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRK 715
+ P +G+LL+GPPG KTM+AKA+A ES F I L +KYVGE E+ VR F
Sbjct: 339 LRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAV 397
Query: 716 ARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKD--VTILAATN 773
AR + PSIIF DE+D+L ER G + + R+ + L E DG++ D V ++ ATN
Sbjct: 398 ARELQPSIIFIDEVDSLLCERRE--GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATN 455
Query: 774 RPDRIDKALMRPGRIDRIIYVPLPDAATRREIFK--LQFHSMPVSNEVDLDELILQTDAY 831
RP +D+A++R R + +YV LP+ TR + K L P++ + +L +L TD Y
Sbjct: 456 RPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK-ELAQLARMTDGY 512
Query: 832 SGAEIVAVCREAALLALEE----------DIQANLIMKRHFTQALS----TVTPRIPESL 877
SG+++ A+ ++AAL + E + I FT++L +V+P+ E+
Sbjct: 513 SGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAY 572
Query: 878 RRFYEDY 884
R+ +D+
Sbjct: 573 IRWNKDF 579
>gi|11875211 spastin isoform 1 [Homo sapiens]
Length = 616
Score = 178 bits (452), Expect = 2e-44
Identities = 114/287 (39%), Positives = 166/287 (57%), Gaps = 14/287 (4%)
Query: 333 NFTEIDKN------SKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPA 386
NF +D N ++ DN V +D I G +A++EI+ LP +PELF PA
Sbjct: 316 NFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPA 375
Query: 387 PRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRH 446
RG+LL+GPPG GKTM+A+AVA E A I+ + SK+ GE E +R +FA A
Sbjct: 376 -RGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQ 434
Query: 447 PSIIFIDELDA-LCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHAL 505
PSIIFIDE+D+ LC +REG +++ +R+ L DG+ S + +VLV+GATNRP L
Sbjct: 435 PSIIFIDEVDSLLCERREG-EHDASRRLKTEFLIEFDGVQS-AGDDRVLVMGATNRPQEL 492
Query: 506 DAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLK 565
D A+ R RF K + + +PN + RL +L+ LL + LT+ EL QLA GY G+DL
Sbjct: 493 DEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLT 550
Query: 566 VLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPS 612
L +A L +R + K + ++ + + I L DF +++ I+ S
Sbjct: 551 ALAKDAALGPIREL--KPEQVKNMSASEMRNIRLSDFTESLKKIKRS 595
Score = 153 bits (387), Expect = 6e-37
Identities = 107/307 (34%), Positives = 165/307 (53%), Gaps = 24/307 (7%)
Query: 596 KITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIR 655
K LK+F +++ M EI + V + DI G + K L++ V P PE F
Sbjct: 311 KKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTG 370
Query: 656 MGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRK 715
+ P +G+LL+GPPG KTM+AKA+A ES F I L +KYVGE E+ VR F
Sbjct: 371 LRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAV 429
Query: 716 ARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKD--VTILAATN 773
AR + PSIIF DE+D+L ER G + + R+ + L E DG++ D V ++ ATN
Sbjct: 430 ARELQPSIIFIDEVDSLLCERRE--GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATN 487
Query: 774 RPDRIDKALMRPGRIDRIIYVPLPDAATRREIFK--LQFHSMPVSNEVDLDELILQTDAY 831
RP +D+A++R R + +YV LP+ TR + K L P++ + +L +L TD Y
Sbjct: 488 RPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQK-ELAQLARMTDGY 544
Query: 832 SGAEIVAVCREAALLALEE----------DIQANLIMKRHFTQALS----TVTPRIPESL 877
SG+++ A+ ++AAL + E + I FT++L +V+P+ E+
Sbjct: 545 SGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAY 604
Query: 878 RRFYEDY 884
R+ +D+
Sbjct: 605 IRWNKDF 611
>gi|31742536 fidgetin-like 1 [Homo sapiens]
Length = 674
Score = 177 bits (448), Expect = 5e-44
Identities = 101/289 (34%), Positives = 160/289 (55%), Gaps = 18/289 (6%)
Query: 614 MREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCS 673
M EI P V+W DI G+E K +++ V WP+ P+ F + PPKG+LL+GPPG
Sbjct: 388 MNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTG 446
Query: 674 KTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALA 733
KT+I K +A++SG F +I L +K+VGE E+ VR F AR P++IF DE+D+L
Sbjct: 447 KTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLL 506
Query: 734 VERGSSLGAGNVADRVLAQLLTEMDGIEQLKD--VTILAATNRPDRIDKALMRPGRIDRI 791
+RG G + R+ + L ++DG + + ++ ATNRP ID+A R R+ +
Sbjct: 507 SQRGD--GEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKR 562
Query: 792 IYVPLPDAATRREI-FKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAAL----- 845
+Y+PLP+A+ R++I L +E ++++++ Q+DA+SGA++ +CREA+L
Sbjct: 563 LYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRS 622
Query: 846 -----LALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYEDYQEKSG 889
+A Q I F A TV P + YE++ + G
Sbjct: 623 LQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFG 671
Score = 159 bits (402), Expect = 1e-38
Identities = 92/263 (34%), Positives = 149/263 (56%), Gaps = 6/263 (2%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409
V ++ I G+ I+EI+ P+ +P++F P P+G+LL+GPPGTGKT+I + +A+
Sbjct: 398 VNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGP-PKGILLFGPPGTGKTLIGKCIAS 456
Query: 410 EVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEV 469
+ GA I+ + SK+ GE E +R +FA A + P++IFIDE+D+L +R ++E
Sbjct: 457 QSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHES 516
Query: 470 EKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDR 529
+R+ L +DG + SE ++LV+GATNRP +D A RR R K + I +P A R
Sbjct: 517 SRRIKTEFLVQLDG-ATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASAR 573
Query: 530 LDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDV 589
I+ L+ + L+E E+ Q+ + + GAD+ LC EA L +R + + ++ +
Sbjct: 574 KQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSL--QTADIATI 631
Query: 590 KVAGLVKITLKDFLQAMNDIRPS 612
+ I DF A +RPS
Sbjct: 632 TPDQVRPIAYIDFENAFRTVRPS 654
>gi|112789543 fidgetin-like 1 [Homo sapiens]
Length = 674
Score = 177 bits (448), Expect = 5e-44
Identities = 101/289 (34%), Positives = 160/289 (55%), Gaps = 18/289 (6%)
Query: 614 MREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCS 673
M EI P V+W DI G+E K +++ V WP+ P+ F + PPKG+LL+GPPG
Sbjct: 388 MNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTG 446
Query: 674 KTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALA 733
KT+I K +A++SG F +I L +K+VGE E+ VR F AR P++IF DE+D+L
Sbjct: 447 KTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLL 506
Query: 734 VERGSSLGAGNVADRVLAQLLTEMDGIEQLKD--VTILAATNRPDRIDKALMRPGRIDRI 791
+RG G + R+ + L ++DG + + ++ ATNRP ID+A R R+ +
Sbjct: 507 SQRGD--GEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKR 562
Query: 792 IYVPLPDAATRREI-FKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAAL----- 845
+Y+PLP+A+ R++I L +E ++++++ Q+DA+SGA++ +CREA+L
Sbjct: 563 LYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRS 622
Query: 846 -----LALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYEDYQEKSG 889
+A Q I F A TV P + YE++ + G
Sbjct: 623 LQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFG 671
Score = 159 bits (402), Expect = 1e-38
Identities = 92/263 (34%), Positives = 149/263 (56%), Gaps = 6/263 (2%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVAN 409
V ++ I G+ I+EI+ P+ +P++F P P+G+LL+GPPGTGKT+I + +A+
Sbjct: 398 VNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGP-PKGILLFGPPGTGKTLIGKCIAS 456
Query: 410 EVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEV 469
+ GA I+ + SK+ GE E +R +FA A + P++IFIDE+D+L +R ++E
Sbjct: 457 QSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHES 516
Query: 470 EKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDR 529
+R+ L +DG + SE ++LV+GATNRP +D A RR R K + I +P A R
Sbjct: 517 SRRIKTEFLVQLDG-ATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASAR 573
Query: 530 LDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDV 589
I+ L+ + L+E E+ Q+ + + GAD+ LC EA L +R + + ++ +
Sbjct: 574 KQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSL--QTADIATI 631
Query: 590 KVAGLVKITLKDFLQAMNDIRPS 612
+ I DF A +RPS
Sbjct: 632 TPDQVRPIAYIDFENAFRTVRPS 654
>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 173 bits (439), Expect = 6e-43
Identities = 102/253 (40%), Positives = 150/253 (59%), Gaps = 13/253 (5%)
Query: 608 DIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPP-KGVLL 666
D+ + R+I P++ W DI LE K L +AV P+ P+ F GI+ P KGVL+
Sbjct: 189 DLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFF--KGIRRPWKGVLM 246
Query: 667 YGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFF 726
GPPG KTM+AKA+A E G F + L +KY GESE+ VR F AR AP+ IF
Sbjct: 247 VGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFI 306
Query: 727 DELDALAVERGSSLGAGNVADRVLAQLLTEMDGI-------EQLKDVTILAATNRPDRID 779
DE+D++ RG+S + RV ++LL +MDG+ + K V +LAATN P ID
Sbjct: 307 DEIDSICSRRGTS-DEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365
Query: 780 KALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAV 839
+AL R R+++ IY+PLP A R E+ K+ + + ++ L+++ + + YSGA+I V
Sbjct: 366 EALRR--RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNV 423
Query: 840 CREAALLALEEDI 852
CR+A+L+A+ I
Sbjct: 424 CRDASLMAMRRRI 436
Score = 155 bits (392), Expect = 2e-37
Identities = 95/235 (40%), Positives = 138/235 (58%), Gaps = 11/235 (4%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAP-RGVLLYGPPGTGKTMIARAVA 408
+ +D I L K +RE + LP+ P+ FK GI P +GVL+ GPPGTGKTM+A+AVA
Sbjct: 205 IHWDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKAVA 262
Query: 409 NEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR-EGAQN 467
E G ++ + SK+ GE+E +R +F A P+ IFIDE+D++C +R ++
Sbjct: 263 TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEH 322
Query: 468 EVEKRVVASLLTLMDGIGSEVSEG----QVLVLGATNRPHALDAALRRPGRFDKEIEIGV 523
E +RV + LL MDG+G + V+VL ATN P +D ALRR R +K I I +
Sbjct: 323 EASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPL 380
Query: 524 PNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRR 578
P A+ R ++L+ LR V L + +L +A GY GAD+ +C +A L A+RR
Sbjct: 381 PTAKGRAELLKINLREV-ELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRR 434
>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 173 bits (439), Expect = 6e-43
Identities = 102/253 (40%), Positives = 150/253 (59%), Gaps = 13/253 (5%)
Query: 608 DIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPP-KGVLL 666
D+ + R+I P++ W DI LE K L +AV P+ P+ F GI+ P KGVL+
Sbjct: 189 DLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFF--KGIRRPWKGVLM 246
Query: 667 YGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFF 726
GPPG KTM+AKA+A E G F + L +KY GESE+ VR F AR AP+ IF
Sbjct: 247 VGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFI 306
Query: 727 DELDALAVERGSSLGAGNVADRVLAQLLTEMDGI-------EQLKDVTILAATNRPDRID 779
DE+D++ RG+S + RV ++LL +MDG+ + K V +LAATN P ID
Sbjct: 307 DEIDSICSRRGTS-DEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDID 365
Query: 780 KALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAV 839
+AL R R+++ IY+PLP A R E+ K+ + + ++ L+++ + + YSGA+I V
Sbjct: 366 EALRR--RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNV 423
Query: 840 CREAALLALEEDI 852
CR+A+L+A+ I
Sbjct: 424 CRDASLMAMRRRI 436
Score = 155 bits (392), Expect = 2e-37
Identities = 95/235 (40%), Positives = 138/235 (58%), Gaps = 11/235 (4%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAP-RGVLLYGPPGTGKTMIARAVA 408
+ +D I L K +RE + LP+ P+ FK GI P +GVL+ GPPGTGKTM+A+AVA
Sbjct: 205 IHWDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKAVA 262
Query: 409 NEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR-EGAQN 467
E G ++ + SK+ GE+E +R +F A P+ IFIDE+D++C +R ++
Sbjct: 263 TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEH 322
Query: 468 EVEKRVVASLLTLMDGIGSEVSEG----QVLVLGATNRPHALDAALRRPGRFDKEIEIGV 523
E +RV + LL MDG+G + V+VL ATN P +D ALRR R +K I I +
Sbjct: 323 EASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPL 380
Query: 524 PNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRR 578
P A+ R ++L+ LR V L + +L +A GY GAD+ +C +A L A+RR
Sbjct: 381 PTAKGRAELLKINLREV-ELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRR 434
>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
Length = 491
Score = 173 bits (438), Expect = 7e-43
Identities = 103/254 (40%), Positives = 150/254 (59%), Gaps = 13/254 (5%)
Query: 608 DIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPP-KGVLL 666
D+ + R+I PNV W DI L K L++AV P+ PE F GI+ P KGVL+
Sbjct: 190 DLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFF--KGIRRPWKGVLM 247
Query: 667 YGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFF 726
GPPG KT++AKA+A E F + L +KY GESE+ VR F AR +P+ IF
Sbjct: 248 VGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFI 307
Query: 727 DELDALAVERGSSLGAGNVADRVLAQLLTEMDGI-------EQLKDVTILAATNRPDRID 779
DE+D++ RG+S + RV A+LL +MDG+ + K V +LAATN P ID
Sbjct: 308 DEIDSICSRRGTS-EEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDID 366
Query: 780 KALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAV 839
+AL R R+++ IY+PLP A R E+ ++ + ++++VDL + + YSGA+I V
Sbjct: 367 EALRR--RLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNV 424
Query: 840 CREAALLALEEDIQ 853
CR+A+L+A+ I+
Sbjct: 425 CRDASLMAMRRRIE 438
Score = 156 bits (394), Expect = 9e-38
Identities = 102/275 (37%), Positives = 156/275 (56%), Gaps = 20/275 (7%)
Query: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAP-RGVLLYGPPGTGKTMIARAVA 408
V +D I L K ++E + LP+ PE FK GI P +GVL+ GPPGTGKT++A+AVA
Sbjct: 206 VRWDDIADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKAVA 263
Query: 409 NEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR-EGAQN 467
E ++ + SK+ GE+E +R +F A P+ IFIDE+D++C +R ++
Sbjct: 264 TECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEH 323
Query: 468 EVEKRVVASLLTLMDGIG----SEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGV 523
E +RV A LL MDG+G ++ V+VL ATN P +D ALRR R +K I I +
Sbjct: 324 EASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPL 381
Query: 524 PNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQ 583
P+A+ R ++L+ LR + L + +L +A + GY GAD+ +C +A L A+RR ++
Sbjct: 382 PSAKGREELLRISLREL-ELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIE-- 438
Query: 584 PNLPDVKVAGLVK------ITLKDFLQAMNDIRPS 612
L ++ L K T++DF A+ + S
Sbjct: 439 -GLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKS 472
>gi|169167838 PREDICTED: similar to hCG2002932 [Homo sapiens]
Length = 415
Score = 168 bits (426), Expect = 2e-41
Identities = 98/277 (35%), Positives = 154/277 (55%), Gaps = 19/277 (6%)
Query: 606 MNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVL 665
M+D P P ++ + GGL++ ++++++E PL HPE + MG +PPKGV+
Sbjct: 151 MDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVI 210
Query: 666 LYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIF 725
L GPPG + FL + G EL+ KY+G+ + VR+ F+ A APSI+F
Sbjct: 211 LCGPPGTA--------------TFLRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMF 256
Query: 726 FDELDALAVERGSSLGAGN--VADRVLA-QLLTEMDGIEQLKDVTILAATNRPDRIDKAL 782
DE++A+ +R S G + +L +LL ++ G + +DV ++ AT + + +D L
Sbjct: 257 TDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVL 316
Query: 783 MRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCRE 842
+RPGRID+ I LPD T++ IF++ M ++N+V LD+LI+ D +SGA+I A+C E
Sbjct: 317 IRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTE 376
Query: 843 AALLALEEDIQ--ANLIMKRHFTQALSTVTPRIPESL 877
A L+AL E N K+ L IPE L
Sbjct: 377 AGLMALREHRMKATNEDFKKSIESVLYKKHEGIPEGL 413
Score = 132 bits (333), Expect = 1e-30
Identities = 85/239 (35%), Positives = 128/239 (53%), Gaps = 21/239 (8%)
Query: 351 TYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANE 410
TY GGL +Q++ I+E +ELPL PE ++ G P+GV+L GPPGT
Sbjct: 170 TYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGT------------ 217
Query: 411 VGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQ 466
++ V+ G E+I K+ G+ +RQ+F A PSI+F DE++A+ KR G +
Sbjct: 218 -ATFLRVV-GSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGE 275
Query: 467 NEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNA 526
E+++ ++ L L++ +G S V V+ AT + LD L RPGR DK+IE +P+
Sbjct: 276 REIQQTMLE--LELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDE 333
Query: 527 QDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPN 585
+ + I Q R+ L + L L + + GAD+K +C EAGL ALR K N
Sbjct: 334 KTKKHIFQIHTSRMT-LANDVTLDDLIMAKDDFSGADIKAICTEAGLMALREHRMKATN 391
>gi|239748566 PREDICTED: similar to hCG2002932 [Homo sapiens]
Length = 415
Score = 168 bits (426), Expect = 2e-41
Identities = 98/277 (35%), Positives = 154/277 (55%), Gaps = 19/277 (6%)
Query: 606 MNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVL 665
M+D P P ++ + GGL++ ++++++E PL HPE + MG +PPKGV+
Sbjct: 151 MDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVI 210
Query: 666 LYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIF 725
L GPPG + FL + G EL+ KY+G+ + VR+ F+ A APSI+F
Sbjct: 211 LCGPPGTA--------------TFLRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMF 256
Query: 726 FDELDALAVERGSSLGAGN--VADRVLA-QLLTEMDGIEQLKDVTILAATNRPDRIDKAL 782
DE++A+ +R S G + +L +LL ++ G + +DV ++ AT + + +D L
Sbjct: 257 TDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVL 316
Query: 783 MRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCRE 842
+RPGRID+ I LPD T++ IF++ M ++N+V LD+LI+ D +SGA+I A+C E
Sbjct: 317 IRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTE 376
Query: 843 AALLALEEDIQ--ANLIMKRHFTQALSTVTPRIPESL 877
A L+AL E N K+ L IPE L
Sbjct: 377 AGLMALREHRMKATNEDFKKSIESVLYKKHEGIPEGL 413
Score = 132 bits (333), Expect = 1e-30
Identities = 85/239 (35%), Positives = 128/239 (53%), Gaps = 21/239 (8%)
Query: 351 TYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANE 410
TY GGL +Q++ I+E +ELPL PE ++ G P+GV+L GPPGT
Sbjct: 170 TYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGT------------ 217
Query: 411 VGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQ 466
++ V+ G E+I K+ G+ +RQ+F A PSI+F DE++A+ KR G +
Sbjct: 218 -ATFLRVV-GSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGE 275
Query: 467 NEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNA 526
E+++ ++ L L++ +G S V V+ AT + LD L RPGR DK+IE +P+
Sbjct: 276 REIQQTMLE--LELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDE 333
Query: 527 QDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPN 585
+ + I Q R+ L + L L + + GAD+K +C EAGL ALR K N
Sbjct: 334 KTKKHIFQIHTSRMT-LANDVTLDDLIMAKDDFSGADIKAICTEAGLMALREHRMKATN 391
>gi|239742549 PREDICTED: hypothetical protein LOC345645 [Homo
sapiens]
Length = 415
Score = 168 bits (426), Expect = 2e-41
Identities = 98/277 (35%), Positives = 154/277 (55%), Gaps = 19/277 (6%)
Query: 606 MNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVL 665
M+D P P ++ + GGL++ ++++++E PL HPE + MG +PPKGV+
Sbjct: 151 MDDTGPLVTMMKVEKAPQETYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVI 210
Query: 666 LYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIF 725
L GPPG + FL + G EL+ KY+G+ + VR+ F+ A APSI+F
Sbjct: 211 LCGPPGTA--------------TFLRVVGSELIQKYLGDGPKLVRQVFQVAEEHAPSIMF 256
Query: 726 FDELDALAVERGSSLGAGN--VADRVLA-QLLTEMDGIEQLKDVTILAATNRPDRIDKAL 782
DE++A+ +R S G + +L +LL ++ G + +DV ++ AT + + +D L
Sbjct: 257 TDEIEAIGTKRYDSNSGGEREIQQTMLELELLNQLGGFDSREDVKVIMATKQVETLDPVL 316
Query: 783 MRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCRE 842
+RPGRID+ I LPD T++ IF++ M ++N+V LD+LI+ D +SGA+I A+C E
Sbjct: 317 IRPGRIDKKIEFHLPDEKTKKHIFQIHTSRMTLANDVTLDDLIMAKDDFSGADIKAICTE 376
Query: 843 AALLALEEDIQ--ANLIMKRHFTQALSTVTPRIPESL 877
A L+AL E N K+ L IPE L
Sbjct: 377 AGLMALREHRMKATNEDFKKSIESVLYKKHEGIPEGL 413
Score = 132 bits (333), Expect = 1e-30
Identities = 85/239 (35%), Positives = 128/239 (53%), Gaps = 21/239 (8%)
Query: 351 TYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANE 410
TY GGL +Q++ I+E +ELPL PE ++ G P+GV+L GPPGT
Sbjct: 170 TYVNTGGLDNQIQEIKESMELPLPHPEYYEEMGTKPPKGVILCGPPGT------------ 217
Query: 411 VGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQ 466
++ V+ G E+I K+ G+ +RQ+F A PSI+F DE++A+ KR G +
Sbjct: 218 -ATFLRVV-GSELIQKYLGDGPKLVRQVFQVAEEHAPSIMFTDEIEAIGTKRYDSNSGGE 275
Query: 467 NEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNA 526
E+++ ++ L L++ +G S V V+ AT + LD L RPGR DK+IE +P+
Sbjct: 276 REIQQTMLE--LELLNQLGGFDSREDVKVIMATKQVETLDPVLIRPGRIDKKIEFHLPDE 333
Query: 527 QDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPN 585
+ + I Q R+ L + L L + + GAD+K +C EAGL ALR K N
Sbjct: 334 KTKKHIFQIHTSRMT-LANDVTLDDLIMAKDDFSGADIKAICTEAGLMALREHRMKATN 391
>gi|156564401 vesicle-fusing ATPase [Homo sapiens]
Length = 744
Score = 167 bits (422), Expect = 5e-41
Identities = 141/457 (30%), Positives = 226/457 (49%), Gaps = 47/457 (10%)
Query: 355 IGGLSSQLKAI-REIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGA 413
IGGL + I R + PE+ + G +G+LLYGPPG GKT++AR + + A
Sbjct: 220 IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA 279
Query: 414 YV-SVINGPEIISKFYGETEAKLRQIFAEATLRHPS--------IIFIDELDALCPKREG 464
V+NGPEI++K+ GE+EA +R++FA+A II DE+DA+C +R
Sbjct: 280 REPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGS 339
Query: 465 AQNE--VEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIG 522
V VV LL+ +DG+ +LV+G TNRP +D AL RPGR + ++EIG
Sbjct: 340 MAGSTGVHDTVVNQLLSKIDGVEQL---NNILVIGMTNRPDLIDEALLRPGRLEVKMEIG 396
Query: 523 VPNAQDRLDILQ---KLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRI 579
+P+ + RL IL +R L + ++ +LA + GA+L+ L A A+ R
Sbjct: 397 LPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRH 456
Query: 580 LKKQPNLP-DVKVAGLVKITLKDFLQAM-NDIRP---SAMREIAIDVPN--VSWSD--IG 630
+K + D++ A +++T DFL ++ NDI+P + + A + N + W D
Sbjct: 457 IKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTR 516
Query: 631 GLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFL 690
L+ +L ++Q K+ + P VLL GPP KT +A +A ES F+
Sbjct: 517 VLDDGELLVQQT-----KNSDR------TPLVSVLLEGPPHSGKTALAAKIAEESNFPFI 565
Query: 691 AIKGPELMNKYVGESE----RAVRETFRKARAVAPSIIFFDELDALAVERGSSLGAGNVA 746
I P+ K +G SE +A+++ F A S + D+++ L N+
Sbjct: 566 KICSPD---KMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLV 622
Query: 747 DRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALM 783
+ L LL + Q + + I+ T+R D + + M
Sbjct: 623 LQALLVLLKKAP--PQGRKLLIIGTTSRKDVLQEMEM 657
Score = 159 bits (401), Expect = 1e-38
Identities = 100/270 (37%), Positives = 158/270 (58%), Gaps = 20/270 (7%)
Query: 605 AMNDIRPSAMREIAIDVPNVSWS----DIGGLESIKLKL-EQAVEWPLKHPESFIRMGIQ 659
++N I + +E + N W+ IGGL+ + +A + PE +MG +
Sbjct: 192 SLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCK 251
Query: 660 PPKGVLLYGPPGCSKTMIAKALANE-SGLNFLAIKGPELMNKYVGESERAVRETFRKA-- 716
KG+LLYGPPGC KT++A+ + + + GPE++NKYVGESE +R+ F A
Sbjct: 252 HVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEE 311
Query: 717 ---RAVAPS---IIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILA 770
R A S II FDE+DA+ +RGS G+ V D V+ QLL+++DG+EQL ++ ++
Sbjct: 312 EQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIG 371
Query: 771 ATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIF-----KLQFHSMPVSNEVDLDELI 825
TNRPD ID+AL+RPGR++ + + LPD R +I +++ H + +S +VD+ EL
Sbjct: 372 MTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQL-LSADVDIKELA 430
Query: 826 LQTDAYSGAEIVAVCREAALLALEEDIQAN 855
++T +SGAE+ + R A A+ I+A+
Sbjct: 431 VETKNFSGAELEGLVRAAQSTAMNRHIKAS 460
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,383,710
Number of Sequences: 37866
Number of extensions: 1438055
Number of successful extensions: 4365
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 3945
Number of HSP's gapped (non-prelim): 235
length of query: 893
length of database: 18,247,518
effective HSP length: 111
effective length of query: 782
effective length of database: 14,044,392
effective search space: 10982714544
effective search space used: 10982714544
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.