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Search of human proteins with 153070258
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153070258 MAGI family member, X-linked isoform a [Homo
sapiens]
(334 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens] 673 0.0
gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens] 487 e-138
gi|153070252 MAGI family member, X-linked isoform c [Homo sapiens] 342 4e-94
gi|153070256 MAGI family member, X-linked isoform d [Homo sapiens] 323 2e-88
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 99 7e-21
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 95 1e-19
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 93 4e-19
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 86 6e-17
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 79 6e-15
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 79 6e-15
gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens] 65 8e-11
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens] 62 5e-10
gi|45827729 scribble isoform b [Homo sapiens] 61 1e-09
gi|45827731 scribble isoform a [Homo sapiens] 61 1e-09
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 60 2e-09
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 60 2e-09
gi|148612825 Rap GTPase interactor [Homo sapiens] 60 3e-09
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 59 5e-09
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 59 6e-09
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 59 6e-09
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 59 6e-09
gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens] 58 1e-08
gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens] 58 1e-08
gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens] 58 1e-08
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 58 1e-08
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 58 1e-08
gi|157388993 synaptojanin 2 binding protein [Homo sapiens] 58 1e-08
gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens] 58 1e-08
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 57 2e-08
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 57 2e-08
>gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens]
Length = 334
Score = 673 bits (1736), Expect = 0.0
Identities = 334/334 (100%), Positives = 334/334 (100%)
Query: 1 MEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLR 60
MEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLR
Sbjct: 1 MEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLR 60
Query: 61 LRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKARSAPKPSQA 120
LRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKARSAPKPSQA
Sbjct: 61 LRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKARSAPKPSQA 120
Query: 121 SGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGE 180
SGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGE
Sbjct: 121 SGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGE 180
Query: 181 STQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGP 240
STQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGP
Sbjct: 181 STQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGP 240
Query: 241 EVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSP 300
EVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSP
Sbjct: 241 EVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSP 300
Query: 301 GPWLVPSEERLSRALGVRGAAQLAQEMAAGRRRH 334
GPWLVPSEERLSRALGVRGAAQLAQEMAAGRRRH
Sbjct: 301 GPWLVPSEERLSRALGVRGAAQLAQEMAAGRRRH 334
>gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens]
Length = 262
Score = 487 bits (1254), Expect = e-138
Identities = 249/269 (92%), Positives = 249/269 (92%), Gaps = 20/269 (7%)
Query: 66 AVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKARSAPKPSQASGHFS 125
AVSVLDSADIEVTDSRLPHATIVDHRPQ GKARSAPKPSQASGHFS
Sbjct: 14 AVSVLDSADIEVTDSRLPHATIVDHRPQ---------------GKARSAPKPSQASGHFS 58
Query: 126 VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 185
VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL
Sbjct: 59 VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 118
Query: 186 THAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEVTGS 245
THAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGV DRSPDPGGPEVTGS
Sbjct: 119 THAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGV-----DRSPDPGGPEVTGS 173
Query: 246 RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLV 305
RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLV
Sbjct: 174 RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLV 233
Query: 306 PSEERLSRALGVRGAAQLAQEMAAGRRRH 334
PSEERLSRALGVRGAAQLAQEMAAGRRRH
Sbjct: 234 PSEERLSRALGVRGAAQLAQEMAAGRRRH 262
>gi|153070252 MAGI family member, X-linked isoform c [Homo sapiens]
Length = 258
Score = 342 bits (876), Expect = 4e-94
Identities = 166/168 (98%), Positives = 167/168 (99%)
Query: 167 RLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGV 226
R +VGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGV
Sbjct: 91 RPQVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGV 150
Query: 227 VPSWPDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPE 286
VPSWPDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPE
Sbjct: 151 VPSWPDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPE 210
Query: 287 RRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGAAQLAQEMAAGRRRH 334
RRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGAAQLAQEMAAGRRRH
Sbjct: 211 RRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGAAQLAQEMAAGRRRH 258
>gi|153070256 MAGI family member, X-linked isoform d [Homo sapiens]
Length = 253
Score = 323 bits (827), Expect = 2e-88
Identities = 161/168 (95%), Positives = 162/168 (96%), Gaps = 5/168 (2%)
Query: 167 RLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGV 226
R +VGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGV
Sbjct: 91 RPQVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGV 150
Query: 227 VPSWPDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPE 286
DRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPE
Sbjct: 151 -----DRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPE 205
Query: 287 RRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGAAQLAQEMAAGRRRH 334
RRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGAAQLAQEMAAGRRRH
Sbjct: 206 RRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGAAQLAQEMAAGRRRH 253
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 98.6 bits (244), Expect = 7e-21
Identities = 94/295 (31%), Positives = 138/295 (46%), Gaps = 62/295 (21%)
Query: 47 DVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVD-HRP-QHRWLETCNA-- 102
D+ L++ AG T+ LR + +S++ + + ATI H P Q ET N
Sbjct: 1045 DIVNLIKEAGNTVTLR---IIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTK 1101
Query: 103 PPQLIQGKARSAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPA 162
P Q Q + + AP+ +Q ++VEL RG GFG +L GGR+ D L V L +DGPA
Sbjct: 1102 PKQESQFEFK-APQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--LYVLRLAEDGPA 1158
Query: 163 QRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR---------PLETHP 213
+RCG++ +GD +L INGE+T+ + H++A+E I+ GG ++ L ++R P
Sbjct: 1159 ERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRH 1218
Query: 214 GK---PRGVGEPRKGVVPSWPDRSPDPG---------------------GPEVTGSRSSS 249
G P+GV E R G PDR P + GSR S
Sbjct: 1219 GPATGPQGVPEVRAG-----PDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYS 1273
Query: 250 TSLVQHPP-SRTTLKKTRGSPEP---SPE----------AAADGPTVSPPERRAE 290
+H + T+ K G+ P +PE AAA+GP PE+R E
Sbjct: 1274 RQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRRE 1328
Score = 56.2 bits (134), Expect = 4e-08
Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%)
Query: 107 IQGKARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRC 165
+QGK PS+ G F +L + GFG T+ GG + D L ++ L+ DGPA
Sbjct: 453 LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP--DEFLQIKSLVLDGPAALD 510
Query: 166 GRLEVGDLVLHINGESTQGLTHAQAVERIRA----GGPQLHLVIRRPLETHPGKP 216
G++E GD+++ +N G THAQ V+ ++ L L PL P P
Sbjct: 511 GKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDP 565
Score = 47.0 bits (110), Expect = 2e-05
Identities = 44/163 (26%), Positives = 69/163 (42%), Gaps = 36/163 (22%)
Query: 124 FSVELVRGY-AGFGLTLGGG--RDVAGDT--------PLAVRGLLKDGPAQRCGRLEVGD 172
+ VE+ RG GFG + R AG T P + +++ PA RCG+L+VGD
Sbjct: 969 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1028
Query: 173 LVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPD 232
+L +NG S +H+ V I+ G + L I PG D
Sbjct: 1029 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI------IPG-----------------D 1065
Query: 233 RSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEA 275
S + +T + +T H PS+ ++TR + +P E+
Sbjct: 1066 ESSN--ATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQES 1106
Score = 45.1 bits (105), Expect = 9e-05
Identities = 52/189 (27%), Positives = 83/189 (43%), Gaps = 35/189 (18%)
Query: 125 SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 184
+V +V+G GFG T+ D G V+ ++ D P RC L+ GDL++ +N ++ Q
Sbjct: 643 TVHIVKGPMGFGFTIA---DSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVEVNKKNVQA 696
Query: 185 LTHAQAVERI--RAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEV 242
LTH Q V+ + G ++ L+++R G +P P +SP E
Sbjct: 697 LTHNQVVDMLVECPKGSEVTLLVQR-----------------GGLPV-PKKSPKSQPLER 738
Query: 243 TGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQI-PGSPG 301
S++SS V S T SP S + + P P E +A D D P
Sbjct: 739 KDSQNSSQHSVSSHRSLHT-----ASPSHSTQVLPEFP---PAEAQAPDQTDSSGQKKPD 790
Query: 302 PWLVPSEER 310
P+ + ++ R
Sbjct: 791 PFKIWAQSR 799
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 94.7 bits (234), Expect = 1e-19
Identities = 68/193 (35%), Positives = 106/193 (54%), Gaps = 14/193 (7%)
Query: 47 DVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVD-HRP-QHRWLETCNA-- 102
D+ L++ AG T+ LR + +S++ + + ATI H P Q ET N
Sbjct: 1074 DIVNLIKEAGNTVTLR---IIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTK 1130
Query: 103 PPQLIQGKARSAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPA 162
P Q Q + + AP+ +Q ++VEL RG GFG +L GGR+ D L V L +DGPA
Sbjct: 1131 PKQESQFEFK-APQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--LYVLRLAEDGPA 1187
Query: 163 QRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEP 222
+RCG++ +GD +L INGE+T+ + H++A+E I+ GG ++ L ++R G G
Sbjct: 1188 ERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR----GDGSVPEYGGS 1243
Query: 223 RKGVVPSWPDRSP 235
+PS+P +P
Sbjct: 1244 NYENIPSFPGMTP 1256
Score = 56.2 bits (134), Expect = 4e-08
Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%)
Query: 107 IQGKARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRC 165
+QGK PS+ G F +L + GFG T+ GG + D L ++ L+ DGPA
Sbjct: 453 LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP--DEFLQIKSLVLDGPAALD 510
Query: 166 GRLEVGDLVLHINGESTQGLTHAQAVERIRA----GGPQLHLVIRRPLETHPGKP 216
G++E GD+++ +N G THAQ V+ ++ L L PL P P
Sbjct: 511 GKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDP 565
Score = 46.6 bits (109), Expect = 3e-05
Identities = 44/164 (26%), Positives = 69/164 (42%), Gaps = 37/164 (22%)
Query: 124 FSVELVRGY-AGFGLTLGGG--RDVAGDT---------PLAVRGLLKDGPAQRCGRLEVG 171
+ VE+ RG GFG + R AG T P + +++ PA RCG+L+VG
Sbjct: 997 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVG 1056
Query: 172 DLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWP 231
D +L +NG S +H+ V I+ G + L I PG
Sbjct: 1057 DRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI------IPG----------------- 1093
Query: 232 DRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEA 275
D S + +T + +T H PS+ ++TR + +P E+
Sbjct: 1094 DESSN--ATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQES 1135
Score = 45.1 bits (105), Expect = 9e-05
Identities = 52/189 (27%), Positives = 83/189 (43%), Gaps = 35/189 (18%)
Query: 125 SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 184
+V +V+G GFG T+ D G V+ ++ D P RC L+ GDL++ +N ++ Q
Sbjct: 643 TVHIVKGPMGFGFTIA---DSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVEVNKKNVQA 696
Query: 185 LTHAQAVERI--RAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEV 242
LTH Q V+ + G ++ L+++R G +P P +SP E
Sbjct: 697 LTHNQVVDMLVECPKGSEVTLLVQR-----------------GGLPV-PKKSPKSQPLER 738
Query: 243 TGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQI-PGSPG 301
S++SS V S T SP S + + P P E +A D D P
Sbjct: 739 KDSQNSSQHSVSSHRSLHT-----ASPSHSTQVLPEFP---PAEAQAPDQTDSSGQKKPD 790
Query: 302 PWLVPSEER 310
P+ + ++ R
Sbjct: 791 PFKIWAQSR 799
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 92.8 bits (229), Expect = 4e-19
Identities = 62/165 (37%), Positives = 97/165 (58%), Gaps = 10/165 (6%)
Query: 47 DVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVD-HRP-QHRWLETCNA-- 102
D+ L++ AG T+ LR + +S++ + + ATI H P Q ET N
Sbjct: 1073 DIVNLIKEAGNTVTLR---IIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTK 1129
Query: 103 PPQLIQGKARSAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPA 162
P Q Q + + AP+ +Q ++VEL RG GFG +L GGR+ D L V L +DGPA
Sbjct: 1130 PKQESQFEFK-APQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--LYVLRLAEDGPA 1186
Query: 163 QRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 207
+RCG++ +GD +L INGE+T+ + H++A+E I+ GG ++ L ++R
Sbjct: 1187 ERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
Score = 56.2 bits (134), Expect = 4e-08
Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%)
Query: 107 IQGKARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRC 165
+QGK PS+ G F +L + GFG T+ GG + D L ++ L+ DGPA
Sbjct: 453 LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP--DEFLQIKSLVLDGPAALD 510
Query: 166 GRLEVGDLVLHINGESTQGLTHAQAVERIRA----GGPQLHLVIRRPLETHPGKP 216
G++E GD+++ +N G THAQ V+ ++ L L PL P P
Sbjct: 511 GKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDP 565
Score = 47.0 bits (110), Expect = 2e-05
Identities = 44/163 (26%), Positives = 69/163 (42%), Gaps = 36/163 (22%)
Query: 124 FSVELVRGY-AGFGLTLGGG--RDVAGDT--------PLAVRGLLKDGPAQRCGRLEVGD 172
+ VE+ RG GFG + R AG T P + +++ PA RCG+L+VGD
Sbjct: 997 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1056
Query: 173 LVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPD 232
+L +NG S +H+ V I+ G + L I PG D
Sbjct: 1057 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI------IPG-----------------D 1093
Query: 233 RSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEA 275
S + +T + +T H PS+ ++TR + +P E+
Sbjct: 1094 ESSN--ATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQES 1134
Score = 45.1 bits (105), Expect = 9e-05
Identities = 52/189 (27%), Positives = 83/189 (43%), Gaps = 35/189 (18%)
Query: 125 SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 184
+V +V+G GFG T+ D G V+ ++ D P RC L+ GDL++ +N ++ Q
Sbjct: 643 TVHIVKGPMGFGFTIA---DSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVEVNKKNVQA 696
Query: 185 LTHAQAVERI--RAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEV 242
LTH Q V+ + G ++ L+++R G +P P +SP E
Sbjct: 697 LTHNQVVDMLVECPKGSEVTLLVQR-----------------GGLPV-PKKSPKSQPLER 738
Query: 243 TGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQI-PGSPG 301
S++SS V S T SP S + + P P E +A D D P
Sbjct: 739 KDSQNSSQHSVSSHRSLHT-----ASPSHSTQVLPEFP---PAEAQAPDQTDSSGQKKPD 790
Query: 302 PWLVPSEER 310
P+ + ++ R
Sbjct: 791 PFKIWAQSR 799
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 85.5 bits (210), Expect = 6e-17
Identities = 65/224 (29%), Positives = 100/224 (44%), Gaps = 20/224 (8%)
Query: 123 HFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 182
+F+V++ +G GFG ++ GGR+ D L V L +DGPA R GR+ VGD ++ INGEST
Sbjct: 1145 YFTVDMEKGAKGFGFSIRGGREYKMD--LYVLRLAEDGPAIRNGRMRVGDQIIEINGEST 1202
Query: 183 QGLTHAQAVERIRAGGPQLHLVIRR----------------PLETHPGKPRGVGEPRKGV 226
+ +THA+A+E I++GG ++ L+++R P PG P G+
Sbjct: 1203 RDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGL 1262
Query: 227 VPSWPDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPE 286
P P P P S + + + R K+ + + P+
Sbjct: 1263 APFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKP-KELSACGQKKQRLGEQRERSASPQ 1321
Query: 287 RRAEDPNDQIPGSPGPWLVPSEERLSRALGVRGAAQLAQEMAAG 330
R A ++ PG G +RA G+ AA A AG
Sbjct: 1322 RAARPRLEEAPGGQGRPEAGRPASEARAPGL-AAADAADAARAG 1364
Score = 55.1 bits (131), Expect = 9e-08
Identities = 47/137 (34%), Positives = 68/137 (49%), Gaps = 17/137 (12%)
Query: 95 RWLETCNAPPQLIQGKARSAP----KP------SQASGHF-SVELVRGYAGFGLTLGGGR 143
R L+ N P + K AP KP SQ G F S L + GFG T+ GG
Sbjct: 385 RKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGD 444
Query: 144 DVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAG--GPQL 201
+ D L V+ ++ DGPA + G++E GD++++IN G THA V+ ++ G +
Sbjct: 445 EP--DEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSV 502
Query: 202 HLVIRR--PLETHPGKP 216
+LV+ R PL P P
Sbjct: 503 NLVLCRGYPLPFDPEDP 519
Score = 43.9 bits (102), Expect = 2e-04
Identities = 25/75 (33%), Positives = 39/75 (52%), Gaps = 3/75 (4%)
Query: 134 GFGLTLGGGRDVAGDT---PLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQA 190
GF + R +G T P + ++ PA RC +L+VGD +L +NG+S + HA
Sbjct: 932 GFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADI 991
Query: 191 VERIRAGGPQLHLVI 205
V+ I+ G + L I
Sbjct: 992 VKLIKDAGLSVTLRI 1006
Score = 42.4 bits (98), Expect = 6e-04
Identities = 28/84 (33%), Positives = 45/84 (53%), Gaps = 4/84 (4%)
Query: 126 VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 185
V L R +GFG + GG D G P+ + ++ G A R GRL GD +++++G G
Sbjct: 779 VHLRRMESGFGFRILGG-DEPGQ-PILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGK 836
Query: 186 THAQAVERIR--AGGPQLHLVIRR 207
TH ++ + A Q++L +RR
Sbjct: 837 THRYVIDLMHHAARNGQVNLTVRR 860
Score = 40.0 bits (92), Expect = 0.003
Identities = 49/196 (25%), Positives = 85/196 (43%), Gaps = 24/196 (12%)
Query: 65 EAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKARSAPKPSQASGHF 124
E +S + ++TD R PH+ + P L+ PP + ++ +QA
Sbjct: 549 EYISRTSQSVPDITD-RPPHS--LHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAE-LM 604
Query: 125 SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 184
++ +V+G GFG T+ D+P R + + Q C L GDL++ IN ++ Q
Sbjct: 605 TLTIVKGAQGFGFTIA-------DSPTGQR-VKQILDIQGCPGLCEGDLIVEINQQNVQN 656
Query: 185 LTHAQAVERIR--AGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEV 242
L+H + V+ ++ G + L+I R G P K P DR + G P+
Sbjct: 657 LSHTEVVDILKDCPIGSETSLIIHR---------GGFFSPWKTPKPIM-DRWENQGSPQT 706
Query: 243 TGSRSSSTSLVQHPPS 258
+ S + + PP+
Sbjct: 707 SLSAPAIPQNLPFPPA 722
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 79.0 bits (193), Expect = 6e-15
Identities = 41/89 (46%), Positives = 61/89 (68%), Gaps = 2/89 (2%)
Query: 118 SQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHI 177
+Q G + VEL RG GFG +L GG++ + L + L +DGPA + GR+ VGD ++ I
Sbjct: 1014 NQNLGCYPVELERGPRGFGFSLRGGKEY--NMGLFILRLAEDGPAIKDGRIHVGDQIVEI 1071
Query: 178 NGESTQGLTHAQAVERIRAGGPQLHLVIR 206
NGE TQG+TH +A+E I+AGG ++ L++R
Sbjct: 1072 NGEPTQGITHTRAIELIQAGGNKVLLLLR 1100
Score = 55.8 bits (133), Expect = 5e-08
Identities = 38/133 (28%), Positives = 64/133 (48%), Gaps = 9/133 (6%)
Query: 96 WLETCNAPPQLIQGKARSAPKPSQASGHFSVELVR----GYAGFGLTLGGGRDVAGDTPL 151
++ T N P+L + + + P P + + V L R G+ GF + + G P
Sbjct: 825 FISTQNGSPRLNRAEVPARPAPQEP---YDVVLQRKENEGF-GFVILTSKNKPPPGVIPH 880
Query: 152 AVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLET 211
+ +++ PA RCG+L+VGD + +NG+S L+H V+ I+ G + L + E
Sbjct: 881 KIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAE-EE 939
Query: 212 HPGKPRGVGEPRK 224
H G P G R+
Sbjct: 940 HHGPPSGTNSARQ 952
Score = 52.4 bits (124), Expect = 6e-07
Identities = 32/84 (38%), Positives = 44/84 (52%), Gaps = 3/84 (3%)
Query: 110 KARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRL 168
K+ PSQ G L + GFG T+ GG D L V+ +LKDGPA + G++
Sbjct: 394 KSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGD--RPDEFLQVKNVLKDGPAAQDGKI 451
Query: 169 EVGDLVLHINGESTQGLTHAQAVE 192
GD+++ ING G THA V+
Sbjct: 452 APGDVIVDINGNCVLGHTHADVVQ 475
Score = 37.4 bits (85), Expect = 0.019
Identities = 43/168 (25%), Positives = 68/168 (40%), Gaps = 16/168 (9%)
Query: 101 NAPPQLIQGKARSAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDG 160
N P + + A S ++ L++G GFG + T V+ +L
Sbjct: 554 NGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADS-----PTGQKVKMILD-- 606
Query: 161 PAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIR--AGGPQLHLVIRR---PLETHPGK 215
+Q C L+ GD++ I ++ Q LTH Q VE ++ G + L+I R P T K
Sbjct: 607 -SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAK 665
Query: 216 PRGVGEPRKGVVPSWPDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLK 263
+ + G + + + P P + RS S L PS LK
Sbjct: 666 MKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKL---DPSEVYLK 710
Score = 33.5 bits (75), Expect = 0.27
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 133 AGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 192
+GFG + GG D + + ++ G A++ GRL D ++ I+G +G +H Q ++
Sbjct: 734 SGFGFRVLGGD--GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD 791
Query: 193 RIRAGGPQLH--LVIRRPL 209
+ H L +RR +
Sbjct: 792 LMTTAARNGHVLLTVRRKI 810
Score = 31.2 bits (69), Expect = 1.4
Identities = 28/109 (25%), Positives = 41/109 (37%), Gaps = 5/109 (4%)
Query: 211 THPGKPRGVGEPRKG--VVPSWPDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGS 268
T+ + V E KG V S D G V + S L Q P + KT
Sbjct: 1371 TNKTTSKEVSENEKGKKVTTGETSSSNDKIGENV---QLSEKRLKQEPEEKVVSNKTEDH 1427
Query: 269 PEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLVPSEERLSRALGV 317
EAA + + P + +PGPW VPS +++ +G+
Sbjct: 1428 KGKELEAADKNKETGRFKPESSSPVKKTLITPGPWKVPSGNKVTGTIGM 1476
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 79.0 bits (193), Expect = 6e-15
Identities = 41/89 (46%), Positives = 61/89 (68%), Gaps = 2/89 (2%)
Query: 118 SQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHI 177
+Q G + VEL RG GFG +L GG++ + L + L +DGPA + GR+ VGD ++ I
Sbjct: 1014 NQNLGCYPVELERGPRGFGFSLRGGKEY--NMGLFILRLAEDGPAIKDGRIHVGDQIVEI 1071
Query: 178 NGESTQGLTHAQAVERIRAGGPQLHLVIR 206
NGE TQG+TH +A+E I+AGG ++ L++R
Sbjct: 1072 NGEPTQGITHTRAIELIQAGGNKVLLLLR 1100
Score = 55.8 bits (133), Expect = 5e-08
Identities = 38/133 (28%), Positives = 64/133 (48%), Gaps = 9/133 (6%)
Query: 96 WLETCNAPPQLIQGKARSAPKPSQASGHFSVELVR----GYAGFGLTLGGGRDVAGDTPL 151
++ T N P+L + + + P P + + V L R G+ GF + + G P
Sbjct: 825 FISTQNGSPRLNRAEVPARPAPQEP---YDVVLQRKENEGF-GFVILTSKNKPPPGVIPH 880
Query: 152 AVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLET 211
+ +++ PA RCG+L+VGD + +NG+S L+H V+ I+ G + L + E
Sbjct: 881 KIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAE-EE 939
Query: 212 HPGKPRGVGEPRK 224
H G P G R+
Sbjct: 940 HHGPPSGTNSARQ 952
Score = 52.4 bits (124), Expect = 6e-07
Identities = 32/84 (38%), Positives = 44/84 (52%), Gaps = 3/84 (3%)
Query: 110 KARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRL 168
K+ PSQ G L + GFG T+ GG D L V+ +LKDGPA + G++
Sbjct: 394 KSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGD--RPDEFLQVKNVLKDGPAAQDGKI 451
Query: 169 EVGDLVLHINGESTQGLTHAQAVE 192
GD+++ ING G THA V+
Sbjct: 452 APGDVIVDINGNCVLGHTHADVVQ 475
Score = 37.4 bits (85), Expect = 0.019
Identities = 43/168 (25%), Positives = 68/168 (40%), Gaps = 16/168 (9%)
Query: 101 NAPPQLIQGKARSAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDG 160
N P + + A S ++ L++G GFG + T V+ +L
Sbjct: 554 NGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADS-----PTGQKVKMILD-- 606
Query: 161 PAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIR--AGGPQLHLVIRR---PLETHPGK 215
+Q C L+ GD++ I ++ Q LTH Q VE ++ G + L+I R P T K
Sbjct: 607 -SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAK 665
Query: 216 PRGVGEPRKGVVPSWPDRSPDPGGPEVTGSRSSSTSLVQHPPSRTTLK 263
+ + G + + + P P + RS S L PS LK
Sbjct: 666 MKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKL---DPSEVYLK 710
Score = 33.5 bits (75), Expect = 0.27
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 133 AGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 192
+GFG + GG D + + ++ G A++ GRL D ++ I+G +G +H Q ++
Sbjct: 734 SGFGFRVLGGD--GPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLD 791
Query: 193 RIRAGGPQLH--LVIRRPL 209
+ H L +RR +
Sbjct: 792 LMTTAARNGHVLLTVRRKI 810
>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
Length = 423
Score = 65.1 bits (157), Expect = 8e-11
Identities = 58/194 (29%), Positives = 87/194 (44%), Gaps = 24/194 (12%)
Query: 128 LVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTH 187
++ G A +G L GG+D + PL++ L G A + G + VGD VL I+GE+ LTH
Sbjct: 7 VLEGPAPWGFRLQGGKDF--NVPLSISRLTPGGKAAQAG-VAVGDWVLSIDGENAGSLTH 63
Query: 188 AQAVERIRAGGPQLHLVIRR--PLETHPGKPRGVG-EPRKGVVP---------SWPDRSP 235
+A +IRA G +L L + R P+++ P K + +P + +VP + D P
Sbjct: 64 IEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTPDKQPLRPLVPDASKQRLMENTEDWRP 123
Query: 236 DPGGPEVTGSR----SSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAED 291
PG + R + T +Q P K ++ P A P S P+
Sbjct: 124 RPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQ-----VPRTEAPAPASSTPQEPWPG 178
Query: 292 PNDQIPGSPGPWLV 305
P P S PW V
Sbjct: 179 PTAPSPTSRPPWAV 192
>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
Length = 596
Score = 62.4 bits (150), Expect = 5e-10
Identities = 69/239 (28%), Positives = 108/239 (45%), Gaps = 43/239 (17%)
Query: 123 HFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 182
++SV LV G A +G L GG+D + PL + L KDG + +GD+VL I+G +
Sbjct: 3 NYSVSLV-GPAPWGFRLQGGKDF--NMPLTISSL-KDGGKAAQANVRIGDVVLSIDGINA 58
Query: 183 QGLTHAQAVERIRAGGPQLHLVIRR--------PLETHPGKPRGVGEPRKGVVPSWP--- 231
QG+TH +A +I+ L++ ++R P+ G+P+ V +P P+
Sbjct: 59 QGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVT 118
Query: 232 -------DRSPDPGG----PEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGP 280
+++P P G P+VT S S++ P+ T T PSP AA P
Sbjct: 119 STNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFT---PAHAT---TSSHASPSPVAAVTPP 172
Query: 281 --TVSPPERRAEDPNDQIPG--SPGPWL--VPSEERLSRALGVRGAAQLAQEMAAGRRR 333
S A DQ P S G VP + ++ ++ +QE+A G+RR
Sbjct: 173 LFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSV-----CSETSQELAEGQRR 226
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 61.2 bits (147), Expect = 1e-09
Identities = 69/247 (27%), Positives = 97/247 (39%), Gaps = 30/247 (12%)
Query: 16 GSRGPSPLAGPSARQLLARLDARPLAARAAVDVA-ALVRRAGATLR-LRRKEAVSVLDSA 73
G +G +P G ++R+ AARA V V L+ G L+ EAV L A
Sbjct: 744 GGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGA 803
Query: 74 ----DIEVTDSRLPH----ATIVDHRPQHRWLETCNAPPQLIQGKARSAPKPSQASGHFS 125
+ V R+ TI RP+ + +P + G R P ++ G
Sbjct: 804 GTAVQMRVWRERMVEPENAVTITPLRPEDDY-----SPRERRGGGLRLPLLPPESPGPLR 858
Query: 126 VE----LVRGYAGFGLTLGGGRDV----AGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHI 177
L R G G ++ GG+ AGD + V + + G A R G L+VGD VL I
Sbjct: 859 QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 918
Query: 178 NGESTQGLTHAQAVERIRAGGPQLHLVIRR----PLETHPGKPRGVGEPRKGVVPSWPDR 233
NG H AV + A P + L++ R PL P P P V +
Sbjct: 919 NGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPL---PPSPLPHSSPPTAAVATTSIT 975
Query: 234 SPDPGGP 240
+ PG P
Sbjct: 976 TATPGVP 982
Score = 46.6 bits (109), Expect = 3e-05
Identities = 52/202 (25%), Positives = 77/202 (38%), Gaps = 37/202 (18%)
Query: 140 GGGRDVAG------DTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVER 193
GG R AG D + + + G A R GRL VG +L +N +S GLTH +AV+
Sbjct: 1117 GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQL 1176
Query: 194 IRAGGPQLHLVI--------RRPLETHPGK-----PRGVGEPR---------KGVVPSWP 231
+R+ G L +++ LE PG G+G + + P P
Sbjct: 1177 LRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGP 1236
Query: 232 DRSPD-PG-----GPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPP 285
+ + PG GPE T + ++ + GS + P AA G P
Sbjct: 1237 GKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESP 1296
Query: 286 ERRAEDPNDQIPGSPGPWLVPS 307
Q P P P +P+
Sbjct: 1297 ---CSPSGQQPPSPPSPDELPA 1315
Score = 39.7 bits (91), Expect = 0.004
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 7/88 (7%)
Query: 126 VELVRGYAGFGLTLGGGRDVAG------DTPLAVRGLLKDGPAQRCGRLEVGDLVLHING 179
+ L R GL++ GG D + + + + +L G A R G L VGD +L +NG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
Query: 180 ESTQGLTHAQAVERIRAGGPQLHLVIRR 207
+ + TH +AV + +L L++RR
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLVRR 1091
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 61.2 bits (147), Expect = 1e-09
Identities = 69/247 (27%), Positives = 97/247 (39%), Gaps = 30/247 (12%)
Query: 16 GSRGPSPLAGPSARQLLARLDARPLAARAAVDVA-ALVRRAGATLR-LRRKEAVSVLDSA 73
G +G +P G ++R+ AARA V V L+ G L+ EAV L A
Sbjct: 744 GGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGA 803
Query: 74 ----DIEVTDSRLPH----ATIVDHRPQHRWLETCNAPPQLIQGKARSAPKPSQASGHFS 125
+ V R+ TI RP+ + +P + G R P ++ G
Sbjct: 804 GTAVQMRVWRERMVEPENAVTITPLRPEDDY-----SPRERRGGGLRLPLLPPESPGPLR 858
Query: 126 VE----LVRGYAGFGLTLGGGRDV----AGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHI 177
L R G G ++ GG+ AGD + V + + G A R G L+VGD VL I
Sbjct: 859 QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 918
Query: 178 NGESTQGLTHAQAVERIRAGGPQLHLVIRR----PLETHPGKPRGVGEPRKGVVPSWPDR 233
NG H AV + A P + L++ R PL P P P V +
Sbjct: 919 NGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPL---PPSPLPHSSPPTAAVATTSIT 975
Query: 234 SPDPGGP 240
+ PG P
Sbjct: 976 TATPGVP 982
Score = 46.6 bits (109), Expect = 3e-05
Identities = 52/202 (25%), Positives = 77/202 (38%), Gaps = 37/202 (18%)
Query: 140 GGGRDVAG------DTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVER 193
GG R AG D + + + G A R GRL VG +L +N +S GLTH +AV+
Sbjct: 1117 GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQL 1176
Query: 194 IRAGGPQLHLVI--------RRPLETHPGK-----PRGVGEPR---------KGVVPSWP 231
+R+ G L +++ LE PG G+G + + P P
Sbjct: 1177 LRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGP 1236
Query: 232 DRSPD-PG-----GPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPP 285
+ + PG GPE T + ++ + GS + P AA G P
Sbjct: 1237 GKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESP 1296
Query: 286 ERRAEDPNDQIPGSPGPWLVPS 307
Q P P P +P+
Sbjct: 1297 ---CSPSGQQPPSPPSPDELPA 1315
Score = 39.7 bits (91), Expect = 0.004
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 7/88 (7%)
Query: 126 VELVRGYAGFGLTLGGGRDVAG------DTPLAVRGLLKDGPAQRCGRLEVGDLVLHING 179
+ L R GL++ GG D + + + + +L G A R G L VGD +L +NG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
Query: 180 ESTQGLTHAQAVERIRAGGPQLHLVIRR 207
+ + TH +AV + +L L++RR
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLVRR 1091
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 60.5 bits (145), Expect = 2e-09
Identities = 45/161 (27%), Positives = 69/161 (42%), Gaps = 19/161 (11%)
Query: 134 GFGLTLGGGRD----VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 189
GFG+ + GGRD +G+T + + +LK GPA+ G+L+ D V +NG S + HA
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
Query: 190 AVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEVTGSRSSS 249
AV+++R G + IRR + R EP D D E+ RS
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS-------DNEEDSYDEEIHDPRSGR 143
Query: 250 TSLVQH------PPSRTTLKKTRGSPEPSPEAAADGPTVSP 284
+ +V P R+ ++ SP + A P
Sbjct: 144 SGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKP 184
Score = 43.5 bits (101), Expect = 3e-04
Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 28/176 (15%)
Query: 52 VRRAG--ATLRLRRKEAVSVL--------------DSADIEVTDSRLPHATIVDHRPQHR 95
+R++G A + +RRK+ V + DS D E+ D R + +V+ R +
Sbjct: 95 LRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKI 154
Query: 96 WLETCNAPPQ--LIQGKARSAPKPSQASGHFSVELVRGYAG--FGLTLGGGRDVAGDTPL 151
W +A + L R + SQ + V LV+ +GL L + +
Sbjct: 155 WPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLA--------SHI 206
Query: 152 AVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 207
V+ + +D A R G ++ GD+VL ING T+ ++ A I +L +V++R
Sbjct: 207 FVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQR 262
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 60.5 bits (145), Expect = 2e-09
Identities = 45/161 (27%), Positives = 69/161 (42%), Gaps = 19/161 (11%)
Query: 134 GFGLTLGGGRD----VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 189
GFG+ + GGRD +G+T + + +LK GPA+ G+L+ D V +NG S + HA
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
Query: 190 AVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEVTGSRSSS 249
AV+++R G + IRR + R EP D D E+ RS
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS-------DNEEDSYDEEIHDPRSGR 143
Query: 250 TSLVQH------PPSRTTLKKTRGSPEPSPEAAADGPTVSP 284
+ +V P R+ ++ SP + A P
Sbjct: 144 SGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKP 184
Score = 43.5 bits (101), Expect = 3e-04
Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 28/176 (15%)
Query: 52 VRRAG--ATLRLRRKEAVSVL--------------DSADIEVTDSRLPHATIVDHRPQHR 95
+R++G A + +RRK+ V + DS D E+ D R + +V+ R +
Sbjct: 95 LRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKI 154
Query: 96 WLETCNAPPQ--LIQGKARSAPKPSQASGHFSVELVRGYAG--FGLTLGGGRDVAGDTPL 151
W +A + L R + SQ + V LV+ +GL L + +
Sbjct: 155 WPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLA--------SHI 206
Query: 152 AVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 207
V+ + +D A R G ++ GD+VL ING T+ ++ A I +L +V++R
Sbjct: 207 FVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQR 262
>gi|148612825 Rap GTPase interactor [Homo sapiens]
Length = 1075
Score = 60.1 bits (144), Expect = 3e-09
Identities = 42/108 (38%), Positives = 57/108 (52%), Gaps = 9/108 (8%)
Query: 113 SAPKPSQASGH-------FSVELVRGYAGFGLTLGGGRDVAGDTP-LAVRGLLKDGPAQR 164
S P PS S F+VEL RG +G G+ L G P L ++ LL PA
Sbjct: 957 SPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAA 1016
Query: 165 CGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLH-LVIRRPLET 211
GRL +GD +L +NG S GL + +AV+ IR GG ++ LV + +ET
Sbjct: 1017 DGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVET 1064
>gi|122937249 glutamate receptor interacting protein 2 [Homo
sapiens]
Length = 1141
Score = 59.3 bits (142), Expect = 5e-09
Identities = 58/187 (31%), Positives = 85/187 (45%), Gaps = 22/187 (11%)
Query: 124 FSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQ 183
++VEL R G+T+ G + P+ + GL K G A+R G + VGD +L IN S +
Sbjct: 753 YTVELKRYGGPLGITISGTEEPFD--PIVISGLTKRGLAERTGAIHVGDRILAINNVSLK 810
Query: 184 GLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDP------ 237
G ++A+ ++ G + L I++ L+ P PR + G + D DP
Sbjct: 811 GRPLSEAIHLLQVAGETVTLKIKKQLD-RPLLPR-----KSGSLSETSDADEDPADALKG 864
Query: 238 GGPEVTGSRS--SSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQ 295
G P S + S S V+ S T G +P+AAA G T P ERR
Sbjct: 865 GLPAARFSPAVPSVDSAVESWDSSATEGGFGGPGSYTPQAAARGTT--PQERRP----GW 918
Query: 296 IPGSPGP 302
+ GSP P
Sbjct: 919 LRGSPPP 925
Score = 46.2 bits (108), Expect = 4e-05
Identities = 29/66 (43%), Positives = 39/66 (59%), Gaps = 4/66 (6%)
Query: 133 AGFGLTLGGG---RDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 189
+GFGL L GG + PL V + D PA+RCG L+VGD VL ING +T+ T +
Sbjct: 563 SGFGLQLQGGIFATETLSSPPL-VCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEE 621
Query: 190 AVERIR 195
A + +R
Sbjct: 622 ANQLLR 627
Score = 42.4 bits (98), Expect = 6e-04
Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 2/81 (2%)
Query: 117 PSQASGHFSVELVRGYAGFGLTLGGGRDVAG--DTPLAVRGLLKDGPAQRCGRLEVGDLV 174
P S V L + FG L GG G PL + + GPA R G L+VGD +
Sbjct: 237 PRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRL 296
Query: 175 LHINGESTQGLTHAQAVERIR 195
L ++G G +HA A+ +R
Sbjct: 297 LSVDGIPLHGASHATALATLR 317
Score = 35.8 bits (81), Expect = 0.055
Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 3/94 (3%)
Query: 117 PSQASGHFSVELVRGYAG-FGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVL 175
P + G VEL++ GLT+ GG D G V L G A R L +GD +
Sbjct: 137 PEEFRGITVVELIKKEGSTLGLTISGGTDKDGKP--RVSNLRPGGLAARSDLLNIGDYIR 194
Query: 176 HINGESTQGLTHAQAVERIRAGGPQLHLVIRRPL 209
+NG L H + + ++ G ++ L + L
Sbjct: 195 SVNGIHLTRLRHDEIITLLKNVGERVVLEVEYEL 228
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 58.9 bits (141), Expect = 6e-09
Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 4/96 (4%)
Query: 113 SAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVA-GDTPLAVRGLLKDGPAQRCGRLEVG 171
S PKP F VEL + G+++ GG + + + V+ ++ G A+ GR+ G
Sbjct: 1168 SPPKPGDI---FEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKG 1224
Query: 172 DLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 207
D VL +NG S +G TH QAVE +R G +HL++ +
Sbjct: 1225 DRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK 1260
Score = 49.7 bits (117), Expect = 4e-06
Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 5/131 (3%)
Query: 124 FSVELVRGYAGFGLTLGGGRDVAGD----TPLAVRGLLKDGPAQRCGRLEVGDLVLHING 179
F V+L + +G G + ++ + + + V+ L PA G+++VGD++L +NG
Sbjct: 1309 FEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNG 1368
Query: 180 ESTQGLTHAQAVERIRAGGPQLHLVI-RRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPG 238
S +GL+ + + +R P++ L++ R P P + P + P+ S D
Sbjct: 1369 ASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSS 1428
Query: 239 GPEVTGSRSSS 249
P +SS
Sbjct: 1429 QPSCVEQSTSS 1439
Score = 43.1 bits (100), Expect = 3e-04
Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 6/81 (7%)
Query: 130 RGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 189
+G GF +T G R V +++D PA+ GRL+ GD ++ +N +TH
Sbjct: 1605 KGSLGFTVTKGNQR-----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTD 1658
Query: 190 AVERIRAGGPQLHLVIRRPLE 210
AV +RA + LVI R LE
Sbjct: 1659 AVNLLRAASKTVRLVIGRVLE 1679
Score = 40.4 bits (93), Expect = 0.002
Identities = 23/78 (29%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Query: 134 GFGLTLGGGRDVAG-DTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 192
G G + GG + D + + + GPA G L+ GD ++ +N S +G++H A+E
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 193 RIRAGGPQLHLVIRRPLE 210
++ + LVI +P E
Sbjct: 972 ILQNAPEDVTLVISQPKE 989
Score = 32.0 bits (71), Expect = 0.79
Identities = 27/111 (24%), Positives = 46/111 (41%), Gaps = 7/111 (6%)
Query: 166 GRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHL-VIRRPLETHPGKPRGVGEPRK 224
G L++ D++ ++NG STQG+T + + P L L R L P R K
Sbjct: 1732 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1791
Query: 225 GVVPSWPDRSPDPGGPEVTGSRSSST------SLVQHPPSRTTLKKTRGSP 269
+ P +T + S ST + + +P + + + +GSP
Sbjct: 1792 STKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSP 1842
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 58.9 bits (141), Expect = 6e-09
Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 4/96 (4%)
Query: 113 SAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVA-GDTPLAVRGLLKDGPAQRCGRLEVG 171
S PKP F VEL + G+++ GG + + + V+ ++ G A+ GR+ G
Sbjct: 1359 SPPKPGDI---FEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKG 1415
Query: 172 DLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 207
D VL +NG S +G TH QAVE +R G +HL++ +
Sbjct: 1416 DRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK 1451
Score = 49.7 bits (117), Expect = 4e-06
Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 5/131 (3%)
Query: 124 FSVELVRGYAGFGLTLGGGRDVAGD----TPLAVRGLLKDGPAQRCGRLEVGDLVLHING 179
F V+L + +G G + ++ + + + V+ L PA G+++VGD++L +NG
Sbjct: 1500 FEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNG 1559
Query: 180 ESTQGLTHAQAVERIRAGGPQLHLVI-RRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPG 238
S +GL+ + + +R P++ L++ R P P + P + P+ S D
Sbjct: 1560 ASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSS 1619
Query: 239 GPEVTGSRSSS 249
P +SS
Sbjct: 1620 QPSCVEQSTSS 1630
Score = 43.1 bits (100), Expect = 3e-04
Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 6/81 (7%)
Query: 130 RGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 189
+G GF +T G R V +++D PA+ GRL+ GD ++ +N +TH
Sbjct: 1796 KGSLGFTVTKGNQR-----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTD 1849
Query: 190 AVERIRAGGPQLHLVIRRPLE 210
AV +RA + LVI R LE
Sbjct: 1850 AVNLLRAASKTVRLVIGRVLE 1870
Score = 40.4 bits (93), Expect = 0.002
Identities = 23/78 (29%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Query: 134 GFGLTLGGGRDVAG-DTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 192
G G + GG + D + + + GPA G L+ GD ++ +N S +G++H A+E
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 193 RIRAGGPQLHLVIRRPLE 210
++ + LVI +P E
Sbjct: 1163 ILQNAPEDVTLVISQPKE 1180
Score = 32.0 bits (71), Expect = 0.79
Identities = 27/111 (24%), Positives = 46/111 (41%), Gaps = 7/111 (6%)
Query: 166 GRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHL-VIRRPLETHPGKPRGVGEPRK 224
G L++ D++ ++NG STQG+T + + P L L R L P R K
Sbjct: 1923 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1982
Query: 225 GVVPSWPDRSPDPGGPEVTGSRSSST------SLVQHPPSRTTLKKTRGSP 269
+ P +T + S ST + + +P + + + +GSP
Sbjct: 1983 STKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSP 2033
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 58.9 bits (141), Expect = 6e-09
Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 4/96 (4%)
Query: 113 SAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVA-GDTPLAVRGLLKDGPAQRCGRLEVG 171
S PKP F VEL + G+++ GG + + + V+ ++ G A+ GR+ G
Sbjct: 1340 SPPKPGDI---FEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKG 1396
Query: 172 DLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 207
D VL +NG S +G TH QAVE +R G +HL++ +
Sbjct: 1397 DRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK 1432
Score = 49.7 bits (117), Expect = 4e-06
Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 5/131 (3%)
Query: 124 FSVELVRGYAGFGLTLGGGRDVAGD----TPLAVRGLLKDGPAQRCGRLEVGDLVLHING 179
F V+L + +G G + ++ + + + V+ L PA G+++VGD++L +NG
Sbjct: 1481 FEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNG 1540
Query: 180 ESTQGLTHAQAVERIRAGGPQLHLVI-RRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPG 238
S +GL+ + + +R P++ L++ R P P + P + P+ S D
Sbjct: 1541 ASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSS 1600
Query: 239 GPEVTGSRSSS 249
P +SS
Sbjct: 1601 QPSCVEQSTSS 1611
Score = 43.1 bits (100), Expect = 3e-04
Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 6/81 (7%)
Query: 130 RGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 189
+G GF +T G R V +++D PA+ GRL+ GD ++ +N +TH
Sbjct: 1777 KGSLGFTVTKGNQR-----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTD 1830
Query: 190 AVERIRAGGPQLHLVIRRPLE 210
AV +RA + LVI R LE
Sbjct: 1831 AVNLLRAASKTVRLVIGRVLE 1851
Score = 40.4 bits (93), Expect = 0.002
Identities = 23/78 (29%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Query: 134 GFGLTLGGGRDVAG-DTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVE 192
G G + GG + D + + + GPA G L+ GD ++ +N S +G++H A+E
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143
Query: 193 RIRAGGPQLHLVIRRPLE 210
++ + LVI +P E
Sbjct: 1144 ILQNAPEDVTLVISQPKE 1161
Score = 32.0 bits (71), Expect = 0.79
Identities = 27/111 (24%), Positives = 46/111 (41%), Gaps = 7/111 (6%)
Query: 166 GRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHL-VIRRPLETHPGKPRGVGEPRK 224
G L++ D++ ++NG STQG+T + + P L L R L P R K
Sbjct: 1904 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1963
Query: 225 GVVPSWPDRSPDPGGPEVTGSRSSST------SLVQHPPSRTTLKKTRGSP 269
+ P +T + S ST + + +P + + + +GSP
Sbjct: 1964 STKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSP 2014
>gi|38327612 PDZ and LIM domain 2 isoform 3 [Homo sapiens]
Length = 278
Score = 58.2 bits (139), Expect = 1e-08
Identities = 56/188 (29%), Positives = 83/188 (44%), Gaps = 27/188 (14%)
Query: 129 VRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHA 188
V G A +G + GGRD TP+ V + + G A+ L GD+++ INGES +G+ HA
Sbjct: 7 VAGPAPWGFRITGGRDF--HTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63
Query: 189 QAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEVTGS--- 245
+A +IR L L + R T PG+ G D S + GS
Sbjct: 64 EAQSKIRQSPSPLRLQLDRSQATSPGQTNG-------------DSSLEVLATRFQGSVRT 110
Query: 246 -RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWL 304
S +SL S T+L GSP P +++ + R + + SPG
Sbjct: 111 YTESQSSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQ----SLACSPG--- 163
Query: 305 VPSEERLS 312
+P+ +RLS
Sbjct: 164 LPAADRLS 171
>gi|28866957 PDZ and LIM domain 2 isoform 1 [Homo sapiens]
Length = 366
Score = 58.2 bits (139), Expect = 1e-08
Identities = 56/188 (29%), Positives = 83/188 (44%), Gaps = 27/188 (14%)
Query: 129 VRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHA 188
V G A +G + GGRD TP+ V + + G A+ L GD+++ INGES +G+ HA
Sbjct: 7 VAGPAPWGFRITGGRDF--HTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63
Query: 189 QAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEVTGS--- 245
+A +IR L L + R T PG+ G D S + GS
Sbjct: 64 EAQSKIRQSPSPLRLQLDRSQATSPGQTNG-------------DSSLEVLATRFQGSVRT 110
Query: 246 -RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWL 304
S +SL S T+L GSP P +++ + R + + SPG
Sbjct: 111 YTESQSSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQ----SLACSPG--- 163
Query: 305 VPSEERLS 312
+P+ +RLS
Sbjct: 164 LPAADRLS 171
>gi|21361888 PDZ and LIM domain 2 isoform 2 [Homo sapiens]
Length = 352
Score = 58.2 bits (139), Expect = 1e-08
Identities = 56/188 (29%), Positives = 83/188 (44%), Gaps = 27/188 (14%)
Query: 129 VRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHA 188
V G A +G + GGRD TP+ V + + G A+ L GD+++ INGES +G+ HA
Sbjct: 7 VAGPAPWGFRITGGRDF--HTPIMVTKVAERGKAKDAD-LRPGDIIVAINGESAEGMLHA 63
Query: 189 QAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEVTGS--- 245
+A +IR L L + R T PG+ G D S + GS
Sbjct: 64 EAQSKIRQSPSPLRLQLDRSQATSPGQTNG-------------DSSLEVLATRFQGSVRT 110
Query: 246 -RSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWL 304
S +SL S T+L GSP P +++ + R + + SPG
Sbjct: 111 YTESQSSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQ----SLACSPG--- 163
Query: 305 VPSEERLS 312
+P+ +RLS
Sbjct: 164 LPAADRLS 171
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 58.2 bits (139), Expect = 1e-08
Identities = 42/164 (25%), Positives = 72/164 (43%), Gaps = 15/164 (9%)
Query: 126 VELVRGYAGFGLTLGGG---RDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 182
++L +G G G ++ GG + + GD + V ++ G AQ+ GRL+VGD +L +N S
Sbjct: 299 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 358
Query: 183 QGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEV 242
+ +TH +AV ++ ++L + +P + P G PD + P
Sbjct: 359 EEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGP-----------PDITHSYSPPME 407
Query: 243 TGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPE 286
S + +++ S + R SP P D PPE
Sbjct: 408 NHLLSGNNGTLEYKTSLPPISPGRYSPIPK-HMLVDDDYTRPPE 450
Score = 52.4 bits (124), Expect = 6e-07
Identities = 26/85 (30%), Positives = 45/85 (52%), Gaps = 3/85 (3%)
Query: 126 VELVRGYAGFGLTLGGGRD---VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 182
+ L RG +G G ++ GG D + D + + ++ G A GRL V D +L +N
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
Query: 183 QGLTHAQAVERIRAGGPQLHLVIRR 207
++H++AVE ++ G + L +RR
Sbjct: 264 SEVSHSKAVEALKEAGSIVRLYVRR 288
Score = 48.1 bits (113), Expect = 1e-05
Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 3/79 (3%)
Query: 126 VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 185
V L +G G G + GG D G + V +L GPA G L+ GD +L +NG +G
Sbjct: 527 VVLHKGSTGLGFNIVGGEDGEG---IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 583
Query: 186 THAQAVERIRAGGPQLHLV 204
+H QA ++ G + ++
Sbjct: 584 SHEQAAAALKGAGQTVTII 602
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 58.2 bits (139), Expect = 1e-08
Identities = 42/164 (25%), Positives = 72/164 (43%), Gaps = 15/164 (9%)
Query: 126 VELVRGYAGFGLTLGGG---RDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 182
++L +G G G ++ GG + + GD + V ++ G AQ+ GRL+VGD +L +N S
Sbjct: 194 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 253
Query: 183 QGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEV 242
+ +TH +AV ++ ++L + +P + P G PD + P
Sbjct: 254 EEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGP-----------PDITHSYSPPME 302
Query: 243 TGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPE 286
S + +++ S + R SP P D PPE
Sbjct: 303 NHLLSGNNGTLEYKTSLPPISPGRYSPIPK-HMLVDDDYTRPPE 345
Score = 52.4 bits (124), Expect = 6e-07
Identities = 26/85 (30%), Positives = 45/85 (52%), Gaps = 3/85 (3%)
Query: 126 VELVRGYAGFGLTLGGGRD---VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 182
+ L RG +G G ++ GG D + D + + ++ G A GRL V D +L +N
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 183 QGLTHAQAVERIRAGGPQLHLVIRR 207
++H++AVE ++ G + L +RR
Sbjct: 159 SEVSHSKAVEALKEAGSIVRLYVRR 183
Score = 48.1 bits (113), Expect = 1e-05
Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 3/79 (3%)
Query: 126 VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 185
V L +G G G + GG D G + V +L GPA G L+ GD +L +NG +G
Sbjct: 422 VVLHKGSTGLGFNIVGGEDGEG---IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 478
Query: 186 THAQAVERIRAGGPQLHLV 204
+H QA ++ G + ++
Sbjct: 479 SHEQAAAALKGAGQTVTII 497
>gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
Length = 145
Score = 57.8 bits (138), Expect = 1e-08
Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 5/102 (4%)
Query: 126 VELVRGYAGFGLTLGGGRD---VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 182
+ L RG +G G + GG D V+ D+ + V + ++G A GRL+ GD +L +NG+
Sbjct: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
Query: 183 QGLTHAQAVERIRAGGPQLHLVIRRPLETHPGK--PRGVGEP 222
+ L H AV+ R G + L ++ L+ G RG G+P
Sbjct: 74 KNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDP 115
>gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]
Length = 457
Score = 57.8 bits (138), Expect = 1e-08
Identities = 60/228 (26%), Positives = 89/228 (39%), Gaps = 58/228 (25%)
Query: 128 LVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTH 187
++ G A +G L GG+D + PL++ L G A + G + VGD VL I+GE+ LTH
Sbjct: 7 VLEGPAPWGFRLQGGKDF--NVPLSISRLTPGGKAAQAG-VAVGDWVLSIDGENAGSLTH 63
Query: 188 AQAVERIRAGGPQLHLVIRR--PLETHPGK------------------------------ 215
+A +IRA G +L L + R P+++ P K
Sbjct: 64 IEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFGAPP 123
Query: 216 -----PRGVGEPRKGVVP---------SWPDRSPDPGGPEVTGSR----SSSTSLVQHPP 257
P+ G+P + +VP + D P PG + R + T +Q P
Sbjct: 124 PADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPD 183
Query: 258 SRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSPGPWLV 305
K ++ P A P S P+ P P S PW V
Sbjct: 184 EEHLKKSSQ-----VPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAV 226
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 57.4 bits (137), Expect = 2e-08
Identities = 49/194 (25%), Positives = 89/194 (45%), Gaps = 22/194 (11%)
Query: 35 LDARPLAARAAVDVAA--LVRRAGATLRLRRKEA----VSVLDSADIEVTDSRL-----P 83
+ RP A R+A+ + A L+R A L + + + +LD + +++S+
Sbjct: 1 MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDE 60
Query: 84 HATIVDHRPQHRWLETCNAPPQLIQGKARSAPKPS-QASG------HFSVELVRGYAGFG 136
++H P H N+PP ++ AP Q +G + + L RG +G G
Sbjct: 61 DTPPLEHSPAHL-PNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLG 119
Query: 137 LTLGGGRD---VAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVER 193
++ GG D + D + + ++ G A + GRL V D +L +N + +TH+ AVE
Sbjct: 120 FSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEA 179
Query: 194 IRAGGPQLHLVIRR 207
++ G + L + R
Sbjct: 180 LKEAGSIVRLYVMR 193
Score = 50.4 bits (119), Expect = 2e-06
Identities = 23/86 (26%), Positives = 48/86 (55%), Gaps = 3/86 (3%)
Query: 126 VELVRGYAGFGLTLGGG---RDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 182
++L++G G G ++ GG + + GD + V +++ G A + GRL++GD +L +N
Sbjct: 204 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 263
Query: 183 QGLTHAQAVERIRAGGPQLHLVIRRP 208
+ + H AV ++ ++L + +P
Sbjct: 264 EDVMHEDAVAALKNTYDVVYLKVAKP 289
Score = 43.9 bits (102), Expect = 2e-04
Identities = 23/75 (30%), Positives = 36/75 (48%), Gaps = 3/75 (4%)
Query: 130 RGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQ 189
RG G G + GG D G + + +L GPA G L GD +L +NG + +H Q
Sbjct: 361 RGSTGLGFNIVGGEDGEG---IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQ 417
Query: 190 AVERIRAGGPQLHLV 204
A ++ G + ++
Sbjct: 418 AAIALKNAGQTVTII 432
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 57.4 bits (137), Expect = 2e-08
Identities = 33/116 (28%), Positives = 59/116 (50%), Gaps = 11/116 (9%)
Query: 101 NAPPQLIQGKARSAPKPSQASG------HFSVELVRGYAGFGLTLGGGRD---VAGDTPL 151
N PP L+ S P+ +G + + L RG +G G ++ GG D + D+ +
Sbjct: 196 NPPPVLVN--TDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSI 253
Query: 152 AVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 207
+ ++ G A + GRL V D +L +N + +TH++AVE ++ G + L ++R
Sbjct: 254 FITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKR 309
Score = 51.6 bits (122), Expect = 1e-06
Identities = 23/86 (26%), Positives = 50/86 (58%), Gaps = 3/86 (3%)
Query: 126 VELVRGYAGFGLTLGGG---RDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGEST 182
++L++G G G ++ GG + + GD + V +++ G A + G+L++GD +L +N
Sbjct: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 379
Query: 183 QGLTHAQAVERIRAGGPQLHLVIRRP 208
+ +TH +AV ++ ++L + +P
Sbjct: 380 EEVTHEEAVTALKNTSDFVYLKVAKP 405
Score = 43.9 bits (102), Expect = 2e-04
Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 4/86 (4%)
Query: 126 VELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQGL 185
V L RG G G + GG D G + + +L GPA G L GD ++ +N +
Sbjct: 467 VVLHRGSTGLGFNIVGGEDGEG---IFISFILAGGPADLSGELRKGDRIISVNSVDLRAA 523
Query: 186 THAQAVERIRAGGPQLHLVIR-RPLE 210
+H QA ++ G + +V + RP E
Sbjct: 524 SHEQAAAALKNAGQAVTIVAQYRPEE 549
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,290,863
Number of Sequences: 37866
Number of extensions: 977446
Number of successful extensions: 7293
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 218
Number of HSP's successfully gapped in prelim test: 491
Number of HSP's that attempted gapping in prelim test: 5067
Number of HSP's gapped (non-prelim): 2666
length of query: 334
length of database: 18,247,518
effective HSP length: 103
effective length of query: 231
effective length of database: 14,347,320
effective search space: 3314230920
effective search space used: 3314230920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.