Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 148886692
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
(4557 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 9071 0.0
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 4652 0.0
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 3305 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 1262 0.0
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 895 0.0
gi|16933557 dachsous 1 precursor [Homo sapiens] 880 0.0
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 668 0.0
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 482 e-135
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 465 e-130
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 460 e-128
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 354 1e-96
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 324 1e-87
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 324 1e-87
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 324 1e-87
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 324 1e-87
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 324 1e-87
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 324 1e-87
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 324 1e-87
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 324 1e-87
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 324 1e-87
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 323 2e-87
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 318 1e-85
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 293 3e-78
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 293 3e-78
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens] 276 3e-73
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens] 276 3e-73
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 273 2e-72
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 273 2e-72
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 273 2e-72
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 271 8e-72
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 9071 bits (23539), Expect = 0.0
Identities = 4557/4557 (100%), Positives = 4557/4557 (100%)
Query: 1 MDIIMGHCVGTRPPACCLILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAART 60
MDIIMGHCVGTRPPACCLILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAART
Sbjct: 1 MDIIMGHCVGTRPPACCLILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAART 60
Query: 61 YVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNRE 120
YVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNRE
Sbjct: 61 YVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNRE 120
Query: 121 IQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQV 180
IQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQV
Sbjct: 121 IQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQV 180
Query: 181 TATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKL 240
TATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKL
Sbjct: 181 TATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKL 240
Query: 241 YGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIES 300
YGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIES
Sbjct: 241 YGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIES 300
Query: 301 VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALK 360
VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALK
Sbjct: 301 VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALK 360
Query: 361 AVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYF 420
AVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYF
Sbjct: 361 AVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYF 420
Query: 421 KINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAY 480
KINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAY
Sbjct: 421 KINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAY 480
Query: 481 VNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSP 540
VNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSP
Sbjct: 481 VNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSP 540
Query: 541 EIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAV 600
EIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAV
Sbjct: 541 EIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAV 600
Query: 601 SAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGEN 660
SAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGEN
Sbjct: 601 SAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGEN 660
Query: 661 LADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINR 720
LADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINR
Sbjct: 661 LADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINR 720
Query: 721 QGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMET 780
QGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMET
Sbjct: 721 QGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMET 780
Query: 781 GQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNI 840
GQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNI
Sbjct: 781 GQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNI 840
Query: 841 LESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANY 900
LESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANY
Sbjct: 841 LESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANY 900
Query: 901 SLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLET 960
SLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLET
Sbjct: 901 SLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLET 960
Query: 961 HDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS 1020
HDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS
Sbjct: 961 HDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS 1020
Query: 1021 LSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQY 1080
LSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQY
Sbjct: 1021 LSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQY 1080
Query: 1081 SIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVED 1140
SIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVED
Sbjct: 1081 SIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVED 1140
Query: 1141 VNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINI 1200
VNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINI
Sbjct: 1141 VNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINI 1200
Query: 1201 KTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ 1260
KTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ
Sbjct: 1201 KTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ 1260
Query: 1261 IKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFT 1320
IKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFT
Sbjct: 1261 IKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFT 1320
Query: 1321 AGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
AGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI
Sbjct: 1321 AGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
Query: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN
Sbjct: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
Query: 1441 VAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSS 1500
VAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSS
Sbjct: 1441 VAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSS 1500
Query: 1501 IDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAN 1560
IDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAN
Sbjct: 1501 IDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAN 1560
Query: 1561 DHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVL 1620
DHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVL
Sbjct: 1561 DHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVL 1620
Query: 1621 GIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEV 1680
GIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEV
Sbjct: 1621 GIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEV 1680
Query: 1681 NENVDIGTSVILISAISQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLI 1740
NENVDIGTSVILISAISQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLI
Sbjct: 1681 NENVDIGTSVILISAISQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLI 1740
Query: 1741 IQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRA 1800
IQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRA
Sbjct: 1741 IQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRA 1800
Query: 1801 TDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQ 1860
TDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQ
Sbjct: 1801 TDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQ 1860
Query: 1861 LTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTY 1920
LTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTY
Sbjct: 1861 LTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTY 1920
Query: 1921 SLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGL 1980
SLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGL
Sbjct: 1921 SLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGL 1980
Query: 1981 HFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGV 2040
HFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGV
Sbjct: 1981 HFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGV 2040
Query: 2041 PFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPG 2100
PFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPG
Sbjct: 2041 PFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPG 2100
Query: 2101 TLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILA 2160
TLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILA
Sbjct: 2101 TLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILA 2160
Query: 2161 KDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGIIY 2220
KDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGIIY
Sbjct: 2161 KDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGIIY 2220
Query: 2221 IIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDV 2280
IIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDV
Sbjct: 2221 IIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDV 2280
Query: 2281 NDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHID 2340
NDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHID
Sbjct: 2281 NDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHID 2340
Query: 2341 SSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYE 2400
SSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYE
Sbjct: 2341 SSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYE 2400
Query: 2401 SYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQR 2460
SYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQR
Sbjct: 2401 SYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQR 2460
Query: 2461 MEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRA 2520
MEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRA
Sbjct: 2461 MEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRA 2520
Query: 2521 TDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGR 2580
TDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGR
Sbjct: 2521 TDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGR 2580
Query: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY
Sbjct: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLP 2700
SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLP
Sbjct: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLP 2700
Query: 2701 PETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQ 2760
PETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQ
Sbjct: 2701 PETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQ 2760
Query: 2761 ETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYD 2820
ETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYD
Sbjct: 2761 ETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYD 2820
Query: 2821 TIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKD 2880
TIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKD
Sbjct: 2821 TIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKD 2880
Query: 2881 LDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPG 2940
LDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPG
Sbjct: 2881 LDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPG 2940
Query: 2941 EVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFL 3000
EVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFL
Sbjct: 2941 EVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFL 3000
Query: 3001 NITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGS 3060
NITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGS
Sbjct: 3001 NITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGS 3060
Query: 3061 NGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLI 3120
NGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLI
Sbjct: 3061 NGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLI 3120
Query: 3121 LEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSI 3180
LEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSI
Sbjct: 3121 LEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSI 3180
Query: 3181 DSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRD 3240
DSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRD
Sbjct: 3181 DSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRD 3240
Query: 3241 YLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLD 3300
YLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLD
Sbjct: 3241 YLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLD 3300
Query: 3301 YELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV 3360
YELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV
Sbjct: 3301 YELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV 3360
Query: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVD 3420
ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVD
Sbjct: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVD 3420
Query: 3421 SGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGP 3480
SGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGP
Sbjct: 3421 SGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGP 3480
Query: 3481 PFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVR 3540
PFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVR
Sbjct: 3481 PFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVR 3540
Query: 3541 VIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNS 3600
VIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNS
Sbjct: 3541 VIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNS 3600
Query: 3601 HDGKIIALGGLDSGKYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPED 3660
HDGKIIALGGLDSGKYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPED
Sbjct: 3601 HDGKIIALGGLDSGKYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPED 3660
Query: 3661 FVGLHMHGFRRTLRNAVLTQKQDSLRIISIQPVAGTNQLDMLFAVEMHSSEFYKPAYLIQ 3720
FVGLHMHGFRRTLRNAVLTQKQDSLRIISIQPVAGTNQLDMLFAVEMHSSEFYKPAYLIQ
Sbjct: 3661 FVGLHMHGFRRTLRNAVLTQKQDSLRIISIQPVAGTNQLDMLFAVEMHSSEFYKPAYLIQ 3720
Query: 3721 KLSNARRHLENIMRISAILEKNCSGLDCQEQHCEQGLSLDSHALMTYSTARISFVCPRFY 3780
KLSNARRHLENIMRISAILEKNCSGLDCQEQHCEQGLSLDSHALMTYSTARISFVCPRFY
Sbjct: 3721 KLSNARRHLENIMRISAILEKNCSGLDCQEQHCEQGLSLDSHALMTYSTARISFVCPRFY 3780
Query: 3781 RNVRCTCNGGLCPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLSF 3840
RNVRCTCNGGLCPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLSF
Sbjct: 3781 RNVRCTCNGGLCPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLSF 3840
Query: 3841 AGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMYTRANPCIILKIVDGKLWFQLDCGS 3900
AGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMYTRANPCIILKIVDGKLWFQLDCGS
Sbjct: 3841 AGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMYTRANPCIILKIVDGKLWFQLDCGS 3900
Query: 3901 GPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGA 3960
GPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGA
Sbjct: 3901 GPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGA 3960
Query: 3961 LVQADNIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLGCVL 4020
LVQADNIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLGCVL
Sbjct: 3961 LVQADNIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLGCVL 4020
Query: 4021 YPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPIGN 4080
YPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPIGN
Sbjct: 4021 YPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPIGN 4080
Query: 4081 TFICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCGLRPVVV 4140
TFICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCGLRPVVV
Sbjct: 4081 TFICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCGLRPVVV 4140
Query: 4141 PNIQAGHSYVGKEELIGIAVVLFVIFILVVLFIVFRKKVFRKNYSRNNITLVQDPATAAL 4200
PNIQAGHSYVGKEELIGIAVVLFVIFILVVLFIVFRKKVFRKNYSRNNITLVQDPATAAL
Sbjct: 4141 PNIQAGHSYVGKEELIGIAVVLFVIFILVVLFIVFRKKVFRKNYSRNNITLVQDPATAAL 4200
Query: 4201 LNKSNGIPFRNLRGSGDGRNVYQEVGPPQVPVRPMAYTPCFQSDSRSNLDKIVDGLGGEH 4260
LNKSNGIPFRNLRGSGDGRNVYQEVGPPQVPVRPMAYTPCFQSDSRSNLDKIVDGLGGEH
Sbjct: 4201 LNKSNGIPFRNLRGSGDGRNVYQEVGPPQVPVRPMAYTPCFQSDSRSNLDKIVDGLGGEH 4260
Query: 4261 QEMTTFHPESPRILTARRGVVVCSVAPNLPAVSPCRSDCDSIRKNGWDAGTENKGVDDPG 4320
QEMTTFHPESPRILTARRGVVVCSVAPNLPAVSPCRSDCDSIRKNGWDAGTENKGVDDPG
Sbjct: 4261 QEMTTFHPESPRILTARRGVVVCSVAPNLPAVSPCRSDCDSIRKNGWDAGTENKGVDDPG 4320
Query: 4321 EVTCFAGSNKGSNSEVQSLSSFQSDSGDDNAYHWDTSDWMPGARLSDIEEVPNYENQDGG 4380
EVTCFAGSNKGSNSEVQSLSSFQSDSGDDNAYHWDTSDWMPGARLSDIEEVPNYENQDGG
Sbjct: 4321 EVTCFAGSNKGSNSEVQSLSSFQSDSGDDNAYHWDTSDWMPGARLSDIEEVPNYENQDGG 4380
Query: 4381 SAHQGSTRELESDYYLGGYDIDSEYPPPHEEEFLSQDQLPPPLPEDFPDQYEALPPSQPV 4440
SAHQGSTRELESDYYLGGYDIDSEYPPPHEEEFLSQDQLPPPLPEDFPDQYEALPPSQPV
Sbjct: 4381 SAHQGSTRELESDYYLGGYDIDSEYPPPHEEEFLSQDQLPPPLPEDFPDQYEALPPSQPV 4440
Query: 4441 SLASTLSPDCRRRPQFHPSQYLPPHPFPNETDLVGPPASCEFSTFAVSMNQGTEPTGPAD 4500
SLASTLSPDCRRRPQFHPSQYLPPHPFPNETDLVGPPASCEFSTFAVSMNQGTEPTGPAD
Sbjct: 4441 SLASTLSPDCRRRPQFHPSQYLPPHPFPNETDLVGPPASCEFSTFAVSMNQGTEPTGPAD 4500
Query: 4501 SVSLSLHNSRGTSSSDVSANCGFDDSEVAMSDYESVGELSLASLHIPFVETQHQTQV 4557
SVSLSLHNSRGTSSSDVSANCGFDDSEVAMSDYESVGELSLASLHIPFVETQHQTQV
Sbjct: 4501 SVSLSLHNSRGTSSSDVSANCGFDDSEVAMSDYESVGELSLASLHIPFVETQHQTQV 4557
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 4652 bits (12066), Expect = 0.0
Identities = 2392/4607 (51%), Positives = 3186/4607 (69%), Gaps = 95/4607 (2%)
Query: 18 LILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSW 77
L+LLLF+ S G FTH YN TV ENSAA+TYV +MG+ + +W
Sbjct: 10 LLLLLFQHFGD-SDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAW 68
Query: 78 DIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED 137
+++Y+IVSGD E FKAEE I+ DFCFLRIRTKGGN+AILNRE++D+Y LIVK + +
Sbjct: 69 EVRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTN 128
Query: 138 LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF 197
+EA TKV +QVLD NDLRPLFSPT+YSV++ E+T +RTS+A+V+ATDADIG+NGEFYY F
Sbjct: 129 VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF 188
Query: 198 KNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIE 257
K++ D+F++HPTSGVI L+GRL+Y E Y++EILA DRGMKLYG++G+SS AKL VHIE
Sbjct: 189 KDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE 248
Query: 258 RINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKE 317
+ NE AP I VT P L+++P YA+VTVDD D GANG+I S+SIVAGD L QF +
Sbjct: 249 QANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRS 308
Query: 318 GKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFE 377
EYK+K IDW+S P+GYNLTLQAKDKG+P + S++K +++ +P P++FE
Sbjct: 309 FPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFE 368
Query: 378 KEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNT 437
K+VY ISEF+PP V +VK P + Y F +N +GLI P+
Sbjct: 369 KDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKR 428
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
+ ++LEVT + +V + + AN + PEF Q Y A +E+VP+GT+V+++SA
Sbjct: 429 QQAAHFELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAV 488
Query: 498 DKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYR 557
D D+GENGY+TYSIA+LN +PF I+ FTG +ST+E LD+E P +Y +RASDWG PYR
Sbjct: 489 DPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYR 548
Query: 558 HESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIIS 617
E EV TI + N+NDN+PLFEK+ C+G I D VG IT VSAID DEL+LV+Y+I +
Sbjct: 549 REVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEA 608
Query: 618 GNELGFFYLNPDSGVLQLKKSLTNS-GIKNGNFALRITATDGENLADPMSINISVLHGKV 676
GNEL FF LNP+SGVL LK+SL + G K +LRITATDGEN A P+ INI+V
Sbjct: 609 GNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASH- 667
Query: 677 SSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVK 736
+ C ET VA+ LAEKLL K + + +ED F D +S+N P F + P+ + VK
Sbjct: 668 KLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVK 727
Query: 737 EDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDL 796
E+ PVG++++ + + D D+GFNGK+++ +S GN DSCF IDMETG LK+L P+DRE TD
Sbjct: 728 ENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDK 787
Query: 797 YLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEAR 856
Y LNIT+YDLG PQK++WRLL + V DANDN P F+Q+SY V + E + +EIIQVEA
Sbjct: 788 YTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEAT 847
Query: 857 DKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQL 916
DKDLG NG VTYS++TDT F+I+S TG+V +A LDRE + +SLKIEARD+A QL
Sbjct: 848 DKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQL 907
Query: 917 FSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV 976
FS V +KV L+DVND P FIP +Y VKV EDLP GTVI WLE HDPDLG GQVRYSL+
Sbjct: 908 FSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLL 967
Query: 977 NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
+ G F++DK SGA+R+ ++LD+EK+Q YNLTVRAKDKG+PVSLSS +VEVEVVDVNE
Sbjct: 968 DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNE 1027
Query: 1037 NLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDE 1096
NLH P F F G+VKE++ +G+ V+ V+A DED+ RDGEI+YSIRDGSG+G F I +E
Sbjct: 1028 NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEE 1087
Query: 1097 SGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPV 1156
+GVI +D LDRE+ YWLTV+ATD+GVVPL S IE+YIEVEDVNDNAP TSEP+YYP
Sbjct: 1088 TGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPE 1147
Query: 1157 VMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQ 1216
+MENSPKDVSV+QI+A DPDSSSN+KL Y+ITSGNPQ FF+I+ KTGLITTTSRKLDREQ
Sbjct: 1148 IMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQ 1207
Query: 1217 QAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERD-----RKKR 1271
Q EH LEVTVTD G PK + V+V++LDENDNKPQF +K Y+I+LPER+ R R
Sbjct: 1208 QDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNAR 1267
Query: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILTIKA 1331
EP+Y A D+DEGPNAEISYSI DGN+ GKFFI+PKTG+VSS++ AG YDIL+IKA
Sbjct: 1268 REPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKA 1327
Query: 1332 VDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANT 1391
VDNGRPQKSST RLHIEWI KP PS P++F+E F+ FTVMESD V ++GV+SV+P
Sbjct: 1328 VDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGI 1387
Query: 1392 PLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVL 1451
PLWFDI GGN+DS FD +KG GTI++AKPLDAEQ+S YN++VE TDGT +TQVFIKV+
Sbjct: 1388 PLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVI 1447
Query: 1452 DNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRI 1511
D ND+ P+FS Y+V I ED P+TEILQI A D+DEK+KL YT+ SS D +S++KFR+
Sbjct: 1448 DTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRL 1507
Query: 1512 DPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLY 1571
DP+TG LYT+E+LDHEA +H L +MVRDQ+ P +RN AR++VNV D NDH+P+FT Y
Sbjct: 1508 DPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSY 1567
Query: 1572 EASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDM 1631
+ V+ESAA+GS VLQVTALDKDKG+NAE++Y+IE+GN GN F I+PVLG I KE D
Sbjct: 1568 KGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDR 1627
Query: 1632 TTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVI 1691
+ ++ L +K TD+GSPPMS VRI VT++DN+ PKF K+Y E++E V IG+ V
Sbjct: 1628 SNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVG 1687
Query: 1692 LISAISQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMAS 1751
+++A SQS+++YE+KDG+ F INP+SG I TQKALD+E Y LIIQ TNMAG+++
Sbjct: 1688 MVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLST 1747
Query: 1752 NATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALL 1811
N TV + + DENDNAPVF+ ++Y+G +SE+A INS+V + N PLVIRA DAD + NALL
Sbjct: 1748 NTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALL 1807
Query: 1812 VYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNI 1871
VY IVE + +F +DSSTGAI T+ +LD+E + FHF V V D G+P+L AE V +
Sbjct: 1808 VYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTV 1867
Query: 1872 EVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL-DHF 1930
V D+ND PPVF + ++E LLLPTY GV+V+ V+ATD DS +L YS+ EG++ + F
Sbjct: 1868 HVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKF 1927
Query: 1931 LIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTS 1990
+D +G LT++N + Y L V+ SDG+F + V I VKE+ +S L FTQ YS
Sbjct: 1928 SMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAV 1987
Query: 1991 ISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELY 2050
+ EN+T +A++ A+GN +NEPL Y ILNP +FKI TSGV+ TTG PFDRE+QE +
Sbjct: 1988 VKENSTEAETLAVITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAF 2047
Query: 2051 ELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAID 2110
++VVE + E VA VVV+V +ED NDN+PVFV LPYYA V+VD E G +I VTA+D
Sbjct: 2048 DVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVD 2107
Query: 2111 KDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLST 2170
+D G NGEV Y L++ + HF+I P G + LK+ F D N EY VT++AKDGG P+ S
Sbjct: 2108 RDSGRNGEVHYYLKEHHEHFQIGP-LGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSA 2166
Query: 2171 SVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQ 2230
V +PIT++NKAMPVF+KPFY+A + E I++++P++ + A SPEG + Y I DGDPF Q
Sbjct: 2167 EVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQ 2226
Query: 2231 FNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQP 2290
F I+F+TGV+ V++PLD+E AYKL+IRA+D+LTGA AEV VD++V+D+NDNPP+F Q
Sbjct: 2227 FTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQ 2286
Query: 2291 TYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTAR 2350
+Y TLSEAS+IGT V+QV + D+DSE N+ + YQ+ + S D+FH+DSS+GLI R
Sbjct: 2287 SYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLR 2346
Query: 2351 MLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRG 2410
LD+E + T+ VR++D G P+LSS+V+V + ++D+NDNPP+F Q IYE+ +SE AP G
Sbjct: 2347 TLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHG 2406
Query: 2411 HFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVS 2470
HFVTCV+A DADSSD D+L+YSILSGND F++DS +G+ITLSN + ++P YSLN+S
Sbjct: 2407 HFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLS 2466
Query: 2471 VSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQ 2530
VSDG+F S+ QVH+ V+G NL+SPAF Q+ Y E+ EN T V+ V+ TDGD G YG
Sbjct: 2467 VSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGH 2526
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIV 2590
++Y I+NDFAKDRF I+ GQ+ T E+LDRE P E +S+ + A D GG+ FCTV VI+
Sbjct: 2527 VTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVIL 2586
Query: 2591 VDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADL 2650
D+NDNAPQF +Y ++ + +G V +V A D D+G+N+ ITY++ ++ S SV +
Sbjct: 2587 TDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEAD-SESVKEN 2645
Query: 2651 LEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQ 2710
LEI+ +G + TK + L+N +FFV+AVD G P K S++ VY+ +LPPE LP F++
Sbjct: 2646 LEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSE 2705
Query: 2711 SQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKR 2770
Y+FT++ED IG+ +D +R S V +S V G PE+N+ FVI++++G +KL+K
Sbjct: 2706 PFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKS 2765
Query: 2771 LDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVG 2830
LD ET+ + F + A D ++V +VDV I+V D NDN PVFE+S Y+ I+E +P G
Sbjct: 2766 LDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGG 2825
Query: 2831 TKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFT 2890
+++ Q+RA D D G NGQV YSL SQ +V+E+F I+ TGWI+TLK+LDHE +
Sbjct: 2826 SRVIQIRASDADSGTNGQVMYSL-DQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQ 2884
Query: 2891 FSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWD 2950
VVASD GE LSSTA+V V VTD+ND+ P F E+Y+G V E DP G V+A+LST D
Sbjct: 2885 IKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTD 2944
Query: 2951 RDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFV 3010
D+ ++NRQV+Y ITGG+P G+FA+ +Q+EWKVYVK+PLDRE++D Y L ITATDG F
Sbjct: 2945 ADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFS 3004
Query: 3011 TQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYG 3070
++A+VEV V D NDNSPVC++ Y+ +PED+ K+I+++SA DADI SN I Y+L G
Sbjct: 3005 SKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLG 3064
Query: 3071 SGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPV 3130
SG +F L+P++GELKT LDRE VY L+ +ATDGGGRFCQ++I L LEDVNDN P
Sbjct: 3065 SGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPE 3124
Query: 3131 FSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILE 3190
FS+D Y V+ENT LLTRVQA D D G+NRK++YSL DSA G FSI+ SGII LE
Sbjct: 3125 FSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLE 3184
Query: 3191 QPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTS 3250
+PLDRE Q+ Y +S++A DQ + L++ TV ++VLDINDNPPVFE R+Y TV ED
Sbjct: 3185 KPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDIL 3244
Query: 3251 PGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLV 3310
GT+VL V+A S+DI NAEITY I SGNE GKF I+ KTG + + E LDYE +YL
Sbjct: 3245 VGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLT 3304
Query: 3311 VEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDS 3370
VEA DGGTP+LS VATVN+N+TD+NDN P FSQD Y+ VISEDA++ SVI ++A+D D
Sbjct: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
Query: 3371 QPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTA 3430
N IH+SI++G++ + FT+DPV G VKV K LDRE +SGY+L VQA D+G P +T
Sbjct: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTT 3424
Query: 3431 TVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGN 3490
TVNID+SDVNDN+PVF+ NY+ +IQENKPVG S+LQLVVTD DS HNGPPF F+I++GN
Sbjct: 3425 TVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGN 3484
Query: 3491 EEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPT 3550
+E+ F ++P G+L ++ + E Y+L V+ D+GKPQ S TYI +RVIEES + P
Sbjct: 3485 DEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPA 3544
Query: 3551 AIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNSHDGKIIALGG 3610
+PLEIFI + +++ GGVIGKIHATDQD+YD LT++L + +LF V+S GK+IA
Sbjct: 3545 ILPLEIFITSSGEEYSGGVIGKIHATDQDVYDTLTYSLDPQMDNLFSVSSTGGKLIAHKK 3604
Query: 3611 LDSGKYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPEDFVGLHMHGFR 3670
LD G+Y+LNVSV+DG+F D+ VH+ Q+ EML +T+ IRF N++PE+FVG + F+
Sbjct: 3605 LDIGQYLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQ 3664
Query: 3671 RTLRNAVLTQKQDSLRIISIQPVAGTNQLDMLFAVEMHSSEFYKPAYLIQKLSNARRHLE 3730
R LRN +L +++ ++I+S+Q LD+L VE S L+ K++++ +E
Sbjct: 3665 RALRN-ILGVRRNDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVTDIE 3723
Query: 3731 NI--MRISAILEKNCSGLDCQEQHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTCN 3788
I +RI + +K C+GLDC + C++ +S+D + T+STAR+SFV PR +R C C
Sbjct: 3724 EIIGVRILNVFQKLCAGLDCPWKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCK 3783
Query: 3789 GGLCPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLSFAGNSYIKY 3848
G CP + C + PCP +CVS + C CP G+ G+C G +S++ GNSY+KY
Sbjct: 3784 EGRCPPVHHGCEDDPCPEGSECVS-DPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSYVKY 3842
Query: 3849 RLSENSKEEDFKLALRLRTLQSNGIIMYTRANPCIILKIVDGKLWFQLDCGSGPGILGIS 3908
RL+EN + + KL +RLRT ++ ++MY R IL+I G+L ++ DCGSGPGI+ +
Sbjct: 3843 RLTENENKLEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDCGSGPGIVSVQ 3902
Query: 3909 GRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVQADNIR 3968
VNDG WH+V LE+N N+ L LD + AP +TL+ ++ ++FG ++ R
Sbjct: 3903 SIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQGTR 3962
Query: 3969 SLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLGCVL-YPDACKR 4027
R QV +GF+GC+DS+ LN ELPL +K S+A + ++ GC L + C
Sbjct: 3963 ---HGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCAS 4019
Query: 4028 SPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACF---------------------- 4065
+PCQ+GG C P+GGY C C + + G +CE + C
Sbjct: 4020 NPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCR 4079
Query: 4066 ---------------PNPCRNGGSCDPIGNTFICNCKAGLTGVTCEEDINECEREECENG 4110
PC+NGG+C + +C C +G G C+ DI+EC C +G
Sbjct: 4080 GLYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHG 4139
Query: 4111 GSCVNVFGSFLCNCTPGYVGQYCGLRPVVVPNIQAGHSY-VGKEELIGIAVVLFVIFILV 4169
C N GS+ CNC+ Y G++C PN + +G E IGI V + IF+LV
Sbjct: 4140 ALCENTHGSYHCNCSHEYRGRHC---EDAAPNQYVSTPWNIGLAEGIGIVVFVAGIFLLV 4196
Query: 4170 VLFIVFRKKVFR-KNYSRNNITLVQDPATAALLNKSNGIPFRNLRGSGDGRNVYQEVGPP 4228
V+F++ RK + R K + PATA L R S +N+Y ++ PP
Sbjct: 4197 VVFVLCRKMISRKKKHQAEPKDKHLGPATAFLQ--------RPYFDSKLNKNIYSDI-PP 4247
Query: 4229 QVPVRPMAYTPCFQSDSRSNLDK--IVDGLGGEHQEMTTFHPESPRILTARRGVVVCSVA 4286
QVPVRP++YTP SDSR+NLD+ EH E +TF+PES + R+ V VCSVA
Sbjct: 4248 QVPVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPES--VHGHRKAVAVCSVA 4305
Query: 4287 PNLPAVSPCR--SDCDSIRKNGWDAGTENKGVD-DP-------GEVTCFAGSNKGSNSEV 4336
PNLP P SD DSI+K WD + K VD DP E S + S SEV
Sbjct: 4306 PNLPPPPPSNSPSDSDSIQKPSWDFDYDTKVVDLDPCLSKKPLEEKPSQPYSARESLSEV 4365
Query: 4337 QSLSSFQSDSGDDNAYHWDTSDWMPGARLSDIEEVPNYENQDGGS-AHQGSTRELESDYY 4395
QSLSSFQS+S DDN YHWDTSDWMP L DI+E PNYE D + + +++DYY
Sbjct: 4366 QSLSSFQSESCDDNGYHWDTSDWMPSVPLPDIQEFPNYEVIDEQTPLYSADPNAIDTDYY 4425
Query: 4396 LGGYDIDSEYPPPHEEEFLSQDQLPPPLPEDFPDQYEALPPSQPVSLASTLSPDCRRRPQ 4455
GGYDI+S++PPP E+F + D+L PPLP +F +Q+E++ P + + A +L R R +
Sbjct: 4426 PGGYDIESDFPPP-PEDFPAADEL-PPLPPEFSNQFESIHPPRDMPAAGSLGSSSRNRQR 4483
Query: 4456 FHPSQYLPP-HPF---PNETDLVGPPASCEFSTFAVSMNQGTEPTGPA-DSVSLSLHNSR 4510
F+ +QYLP +P +T G ++C PA +S+ +S++ S
Sbjct: 4484 FNLNQYLPNFYPLDMSEPQTKGTGENSTCREPHAPYPPGYQRHFEAPAVESMPMSVYAST 4543
Query: 4511 GTSSSDVSANCGFDDSEVAMSDYESVGELSLASLHIPFVETQHQTQV 4557
S SDVSA C +SEV MSDYES + + IP +++Q T+V
Sbjct: 4544 -ASCSDVSACCEV-ESEVMMSDYESGDDGHFEEVTIPPLDSQQHTEV 4588
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 3305 bits (8570), Expect = 0.0
Identities = 1853/4432 (41%), Positives = 2635/4432 (59%), Gaps = 217/4432 (4%)
Query: 41 FHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIA 100
+HFTHS YNAT+YENS+ +TYV S +MGI L + W ++YRI+SGD FK EE ++
Sbjct: 31 WHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVG 90
Query: 101 DFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSP 160
+FCFLRIRTK N+A+LNRE++D+Y LI++ + + +LEA T+V + +LD NDL+PLFSP
Sbjct: 91 NFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSP 150
Query: 161 TTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLN 220
+Y VTI+E PL++ + +VTATDAD+G N EFYY F + ++F++HPTSGV++++G+LN
Sbjct: 151 PSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLN 210
Query: 221 YDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEP 280
+ +++L++LAVDR K+ NG S A L VH+E P I V P
Sbjct: 211 VTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGT 270
Query: 281 TYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYG 340
TYA V VD GA E+ESV +V GDP F K NE+ + K I+W + +G
Sbjct: 271 TYATVLVDANSSGA--EVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHG 328
Query: 341 YNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKL 400
+NL+LQA+ P S ++ ++ P ++FEK VY V +SEFSPPG V +V++
Sbjct: 329 FNLSLQARSGSGPYFYSQIRGFHL--PPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRV 386
Query: 401 SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVTI 460
+P +++Y L P + V FK+N R+GLI T + ++ + Y+L + G V I
Sbjct: 387 TPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQASTVVVI 446
Query: 461 SIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFV 520
I D N+H P F + YD ++E++P GTSVL V+A+D+D GENGY+TYSIA LPF
Sbjct: 447 DIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFS 506
Query: 521 INQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEK 580
I+ + G+IST++ +D+E IY F VRASDWGSP+R E EV++ +++ N+NDN P+FE+
Sbjct: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEE 566
Query: 581 VACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
V C G I D+PVG I +SAID+DEL+ +KY+I+SGNEL +F LN SGV+ LK+
Sbjct: 567 VNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFI 626
Query: 641 N-SGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIK 699
N + + +++L+ITA+DG+N A P ++NI+V+ +C +T V + + +L
Sbjct: 627 NLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHF 686
Query: 700 AKANGKLNLEDGF--LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGF 757
+ + ++ F L Y IN P F+ FP + V E +P+ + ++ A D D+GF
Sbjct: 687 IGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGF 746
Query: 758 NGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLL 817
NGK+++ I+DGN + CF+I++ETG L V P+D E T+ Y+LN+T+YDLG PQKSSW+LL
Sbjct: 747 NGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLL 806
Query: 818 TINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQF 877
T+NV+D NDN+P F Y + I E + +GT I ++ +D D NG V Y++L+ T++F
Sbjct: 807 TVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKF 866
Query: 878 AINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI 937
+++ TG + V LDRES+ Y LK+EARD+ G QLFSV L + L+DVND SP I
Sbjct: 867 SLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCI 926
Query: 938 PSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKE 997
+KV EDLP GTV+ +L+ DPDLG G+VRY L++ +G F +D +GA+ L +E
Sbjct: 927 TEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERE 986
Query: 998 LDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSR 1057
LD+E++ YNL++ A D GRP++ ++ VEV V+DVNENLH P+F F G V+ENS
Sbjct: 987 LDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSP 1046
Query: 1058 IGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLT 1117
GT V+ V A+D+DSG DGE+QY +R G+GL FSI+ ++G+I LDRE YWLT
Sbjct: 1047 SGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLT 1106
Query: 1118 VYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDS 1177
V A DRG VPL S EVYIEV D NDN P S+ ++YP + E++P SV+Q+ A DPDS
Sbjct: 1107 VLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDS 1166
Query: 1178 SSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQST 1237
SS KLT+ ITSGN FF I+ TGL+ +T+++LDRE + EH LEVTV D G +ST
Sbjct: 1167 SSKGKLTFNITSGNYMGFFMIHPVTGLL-STAQQLDRENKDEHILEVTVLDNGEPSLKST 1225
Query: 1238 IWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVD 1297
VVV +LD NDN P F K++ ++LPER P+YR A D DEG N ++YSI D
Sbjct: 1226 SRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIED 1285
Query: 1298 GNDDGKFFIDPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSP 1357
+D+ F ID TG+VSS FTAG Y+ILTIKA D+G+P S++ RLHIEWI P PS
Sbjct: 1286 -SDEEAFSIDLVTGVVSSSSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSS 1344
Query: 1358 IPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
IPL FDE +Y+FTVME+D V +VGV+SV+ WF+I GG+ D FD EK G+IVI
Sbjct: 1345 IPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVI 1404
Query: 1418 AKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDN-NDNGPEFSQPNYDVTISEDVLPD 1476
A+PLD +RS YN++VEVTDG+ TQV I ++ N N + P+F + Y+V + +D +P
Sbjct: 1405 ARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPG 1464
Query: 1477 TEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLD-HEAQDKHILN 1535
E+L+++A D+D+ L YT+H S D S F++DPS+GVL T +LD +H L
Sbjct: 1465 VELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLT 1524
Query: 1536 IMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDK 1595
+MVRDQE P +RN V ++VED N H P FT YEASV ++ A G+ +LQV A+D D+
Sbjct: 1525 VMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADR 1584
Query: 1596 GENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATA 1655
G NAE+ Y++ GN+ F I +LGIIT+ ++ D L++K DQGSP A
Sbjct: 1585 GVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLA 1644
Query: 1656 IVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDGDINGIFT 1715
V I V SD S P F +Y E+ E++ +G+ ++L+SA+S S + YE+++G+ +G+F+
Sbjct: 1645 TVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREGNKDGVFS 1704
Query: 1716 INPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYS 1775
+N YSG+I+TQK LD+E+ SSYQL I+ +NMAG ++ V + I+DENDNAP+FL S +
Sbjct: 1705 MNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFV 1764
Query: 1776 GSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRT 1835
G +SEAAP+ S++ +N+P VI A+D+D N+LLVY+I+E A KFF +D S G +
Sbjct: 1765 GQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTI 1824
Query: 1836 IANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLP 1895
++ +D+E++ F F V+V D GSP L A P +V I V DVND+PP F++ ++E ++ P
Sbjct: 1825 VSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGP 1884
Query: 1896 TYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFL-IDSNSGVLTIKNNNLSKDHYMLI 1954
+ G+E+L V A+D DSEV YS+ G+ D + I +G +++ N L
Sbjct: 1885 IHPGMELLMVRASDEDSEV----NYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT 1940
Query: 1955 VKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEP 2014
++ SDG + T++V I + + +D L F Q Y ++ EN + + I+ A GN LN+
Sbjct: 1941 IRASDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDT 2000
Query: 2015 LKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNI 2074
L Y +LN + F + ++GV+QT GV FDRE+Q+ +EL VE RVA+ +VRV+I
Sbjct: 2001 LSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSI 2060
Query: 2075 EDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINP 2134
ED+NDN P F LPYY +Q EPG +++QV+A D+D G NG VTY +DY +F I+P
Sbjct: 2061 EDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRIDP 2120
Query: 2135 NSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTAS 2194
G++ LK+ F+ N +Y + ++A+DGG PSL + E+ +T+ NK+ P+F P+Y
Sbjct: 2121 YLGDISLKKPFDYQALN-KYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVR 2179
Query: 2195 VNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAY 2254
V E+I + TPIL A SPEG +IY I++ +P F DF TGVL V PLDYE + +
Sbjct: 2180 VPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKH 2239
Query: 2255 KLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDA 2314
T+RA+D G+ +E TV++LV DVNDNPP F Q Y T++SE TPV+Q+++ D
Sbjct: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQ 2299
Query: 2315 DSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSL 2374
DS N+ V YQIV+D + + +F I+ S+G + T + LD+E QH +KVR++D G P L
Sbjct: 2300 DSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPL 2359
Query: 2375 SSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL 2434
+ E LV + +SD+NDNPP F Q YE+ VSELA GH V VQA D DS D RLEY IL
Sbjct: 2360 TGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLIL 2419
Query: 2435 SGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSP 2494
SGN F ++S SG+I++ N K+ ++ Y+L V SDG+F +T V+I AN YSP
Sbjct: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTNANKYSP 2479
Query: 2495 AFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVIT 2554
F Q Y AE+ EN GTKVI + A D D G YG I Y IIN A ++F I+ NGQ+ T
Sbjct: 2480 EFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIAT 2539
Query: 2555 TERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
++LDREN E ++I V A DGGGR FCTV++I+ DENDN PQF EY S++++V
Sbjct: 2540 LQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVS 2599
Query: 2615 RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVL 2674
+ V QV A D D+G N+ +TYS+ E V D++EI+P G + K + L+N L
Sbjct: 2600 KDSPVIQVLAYDADEGQNADVTYSVNPEDLVK--DVIEINPVTGVVKVKDSLVGLENQTL 2657
Query: 2675 SFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILP 2734
FF+KA DGG P +SL+PV + V+P + LP F++ Y+F+ ED GS + ++ +
Sbjct: 2658 DFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVA 2717
Query: 2735 SQN-VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVD 2793
+Q+ V +S V G PE+NK G+F ++ +TG IK+ K +D E++ + V A L D
Sbjct: 2718 AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHC-LQNTD 2776
Query: 2794 IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSL 2853
+V V V+I+V D+NDN+PVFE Y ++ E MPVGT + QV AID D G +GQV+Y L
Sbjct: 2777 VVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL 2836
Query: 2854 HSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVR 2913
+D V E F IDS +GWI+TL++LD ET T+ F VVA D G+ LSS ALV V
Sbjct: 2837 SAD-PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVS 2895
Query: 2914 VTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRF 2973
+TD NDNAP FA E YRG+V E+ PGE+VA L T D D S+ NRQV+ +IT G+P G+F
Sbjct: 2896 ITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQF 2955
Query: 2974 ALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVA 3033
+ V EW++ ++ LDRE Y L +TA+DG F VE+ V DVNDNSP C Q+
Sbjct: 2956 GISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLL 3015
Query: 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDR 3093
YT + ED+ ILKVSA D D +N I YSL+G G EF LDP +GEL TL LDR
Sbjct: 3016 YTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDR 3075
Query: 3094 ERIPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRV 3153
ER V++L+AKATDGGGR CQ++I L +EDVNDN P F H V++NT K + V
Sbjct: 3076 ERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVV 3135
Query: 3154 QAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPG 3213
A DPD G N +VVYSL DSA G FSID+++G+I LE+PL Q+ ++VRA+D
Sbjct: 3136 FARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
Query: 3214 QSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT- 3272
LS+L TVT++V+ + D PVF ++ V VPED PGT+VL + ++ AE T
Sbjct: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTR---PGAEKTG 3252
Query: 3273 YLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLT 3332
Y + SGNEQG+F+++ +TG + V+ LD+E +++L +E + +LS V TV +N+T
Sbjct: 3253 YRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNIT 3312
Query: 3333 DVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVD 3392
DVN++ P+F QD YS + E+ALVGD ++ + A D D N I +S++ G++ FT+
Sbjct: 3313 DVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIH 3372
Query: 3393 PVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYT 3452
P G ++V K LDRE+ S YSL ++A DSG P + + I ++DVNDN P F NY+
Sbjct: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYS 3432
Query: 3453 AVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHT 3512
+QEN P+G+ +LQL+++D DS NGPP+SF I GN F + P G L +A
Sbjct: 3433 TTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAEGLSRR 3492
Query: 3513 ESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGK 3572
Y L +QA DSG P S T +RV V E+S + P+A+PLEIFI ED+F GG++GK
Sbjct: 3493 AQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGK 3552
Query: 3573 IHATDQDMYDVLTFALKSEQK--SLFKVNSHDGKIIALGGLDSGKYVLNVSVSDGRFQVP 3630
IHATD+D D LT++L E+ F V + DGKIIA GL G Y NV+VSDG F
Sbjct: 3553 IHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRGHYSFNVTVSDGTFTTT 3612
Query: 3631 IDVVVHVEQLVHEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLRNAVLTQKQDSLRIISI 3690
V V+V + E LQ + + F ++PE+ V H +R L + L K+ ++ + S+
Sbjct: 3613 AGVHVYVWHVGQEALQQAMWMGFYQLTPEELVSDHWRNLQRFLSHK-LDIKRANIHLASL 3671
Query: 3691 QPVAGTNQLDMLFAVEMHSSEFYKPAYLIQKLSNARRHLENIMRI---SAILEKNCSGLD 3747
QP +D+L E HS FY+ L ++++ + +E+ + + SA+ C G
Sbjct: 3672 QPAEAVAGVDVLLVFEGHSGTFYEFQELASIITHSAKEMEHSVGVQMRSAMPMVPCQGPT 3731
Query: 3748 CQEQHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTCNGGLCPGSNDPCVEKPCPGD 3807
CQ Q C + LD TYSTAR+S + PR + C+CNG
Sbjct: 3732 CQGQICHNTVHLDPKVGPTYSTARLSILTPRHHLQRSCSCNG------------------ 3773
Query: 3808 MQCVSYEASRRPFLCQCPPGKLGECSGHTSLSFAGNSYIKYRLSENSKEEDFKLALRLRT 3867
T+ F+G SY++YR ++ + L+T
Sbjct: 3774 ----------------------------TATRFSGQSYVRYRA---PAARNWHIHFYLKT 3802
Query: 3868 LQSNGIIMYTRANPCIILKIVDGKLWFQLDC-GSGPGILGISGRAVNDGSWHSVFLELNR 3926
LQ I+++T + LK+ G + C G G L S R VND WHS+ +E
Sbjct: 3803 LQPQAILLFTNETASVSLKLASGVPQLEYHCLGGFYGNLS-SQRHVNDHEWHSILVEEMD 3861
Query: 3927 NFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVQADNIRSLTDTRVTQVLSGFQGCL 3986
L +D P + L E + G L+ + + V GF+GCL
Sbjct: 3862 ASIRLMVDSMGNTSLVVPENCRGLRPERHLLLGGLILLHS--------SSNVSQGFEGCL 3913
Query: 3987 DSVILNNNELPLQNKRSSFAEVVGLTELKLGCVLYPDACKRSPCQHGGSCTGLPSGGYQC 4046
D+V++N L L + A ++ T+ C L+ D C ++ C +GG C+ GY C
Sbjct: 3914 DAVVVNEEALDLLAPGKTVAGLLE-TQALTQCCLHSDYCSQNTCLNGGKCSWTHGAGYVC 3972
Query: 4047 TCLSQFTGRNCESEITACFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEEDINECEREE 4106
C QF+G++CE C PC GG+C CNC TG CE + C
Sbjct: 3973 KCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARGCSEGH 4032
Query: 4107 CENGGSCVNVFGSFLCNCTPGYVGQYCGLRPVVVPNIQAGHSYVGKEELIGIAV-VLFVI 4165
C +V P IQ G G++EL+ I V V F+I
Sbjct: 4033 C------------------------------LVTPEIQRGD--WGQQELLIITVAVAFII 4060
Query: 4166 FILVVLFIVFRKKVFRKNYSRNNITLVQDPATAALLNKSNGIPFRNLRGSGDGRNVYQEV 4225
V L R+ K + ++DP LL +S G+ + +
Sbjct: 4061 ISTVGLLFYCRRCKSHKPVA------MEDP---DLLARSVGVDTQAM------------- 4098
Query: 4226 GPPQVPVRPMAYTPCFQSDSRSNLDKIVDGLGGEHQEMTTFHPESPRILTARRGVVVCSV 4285
P + + P++ + C +NL++ E+ TF P S ++ VVCSV
Sbjct: 4099 --PAIELNPLSASSC------NNLNQPEPSKASVPNELVTFGPNS------KQRPVVCSV 4144
Query: 4286 APNL-PAVSPCRSDCDSIRKNGWDAGTENKGVDDPGEVTCFAGSNKGSNSEVQSLSSFQS 4344
P L PA P SD + + K W
Sbjct: 4145 PPRLPPAAVPSHSDNEPVIKRTW------------------------------------- 4167
Query: 4345 DSGDDNAYHWDTSDWMPGARLSDIEEVPNYENQDG---GSAHQGSTREL--ESDYYLGGY 4399
S ++ Y W P ++ E P+ E G SAH+ ST + E + GG
Sbjct: 4168 -SSEEMVYPGGAMVWPPTYSRNERWEYPHSEVTQGPLPPSAHRHSTPVVMPEPNGLYGG- 4225
Query: 4400 DIDSEYPPPHEEEFLSQDQLPPPLPEDFPDQ-YEALPPSQPVSLASTLSPDC 4450
+P P L + PLP + +Q E L PS+P S L C
Sbjct: 4226 -----FPFP-----LEMENKRAPLPPRYSNQNLEDLMPSRPPSPRERLVAPC 4267
Score = 392 bits (1008), Expect = e-108
Identities = 450/1751 (25%), Positives = 721/1751 (41%), Gaps = 170/1751 (9%)
Query: 1978 SGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEP---LKYSILNPGNKFKIKSTSGV 2034
S HFT S Y+ +I EN++ T V +G L EP ++Y I++ K+ V
Sbjct: 29 SAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYV 88
Query: 2035 I-----------QTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPV 2083
+ + +RE ++ Y L+++A+ + L VV V+I D ND P+
Sbjct: 89 VGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPL 147
Query: 2084 FVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKE 2143
F Y + D + I +VTA D D G N E Y F I+P SG V +
Sbjct: 148 FSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAG 207
Query: 2144 AFNSDLSNIEYGVTILAKDG-GKPSLSTSVELPITIVNKAMPVFDKPFYTASV------- 2195
N ++ + +LA D K S +V P KP ASV
Sbjct: 208 KLNVTWRG-KHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDS 266
Query: 2196 NEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNI--------DFDTGVLKVVSPLD 2247
N+ T ++ N++ E + + ++ GDP K F +F +K ++ ++
Sbjct: 267 NDGTTYATVLVDANSSGAEVESV--EVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWME 324
Query: 2248 YEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVL 2307
Y + L+++A + + F++ Y LSE S G+ V+
Sbjct: 325 Y--LHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVV 382
Query: 2308 QVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSI 2367
V A + Q V + F +++ +GLI T +++D H L +R+
Sbjct: 383 MVRVTPA------FPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT- 435
Query: 2368 DSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFD 2427
P +S V+V I I D N++ P+FN+ Y+ + E P G V V A+D D +
Sbjct: 436 ---SPGQASTVVV-IDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENG 491
Query: 2428 RLEYSILSGNDRTSFLMDSKSGVITLSNHRK-QRMEPLYSLNVSVSD--GLFTSTAQVHI 2484
+ YSI +G F +D G+I+ S + M+ +Y+ V SD F +V I
Sbjct: 492 YVTYSI-AGPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSI 550
Query: 2485 --RVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKD 2542
++ N P F + +R++ G ++ + A D D + Y I++ +
Sbjct: 551 FLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIVSGNELE 608
Query: 2543 RFLIDSNGQVITTER--LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDE------- 2593
F ++ VI+ +R ++ S+ + A DG + T+ + VV +
Sbjct: 609 YFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPV 668
Query: 2594 ---------------------------------------NDNAPQFMT-VEYRASVRADV 2613
N PQF V V
Sbjct: 669 TCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESV 728
Query: 2614 GRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
+ ++ A DPD G N ++ Y + A + +I+ + G + +
Sbjct: 729 PINTPLARLAATDPDAGFNGKLVYVI---ADGNEEGCFDIELETGLLTVAAPLDYEATNF 785
Query: 2674 LSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRIL 2733
V D G P K S + ++V P F Y TI+EDT +G+T+ L
Sbjct: 786 YILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAEL--- 842
Query: 2734 PSQNVWFSTVNGERPENNKGGI--------FVIEQETGTIKLDKRLDRETSPAFHFKVAA 2785
+T + + +N + F + TG + + LDRE+ P + KV A
Sbjct: 843 -------TTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEA 895
Query: 2786 TIPLDKVDIVFTV-DVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWG 2844
K +F+V D+ I + D+NDN P T + E +P GT LT + A D D G
Sbjct: 896 RDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLG 955
Query: 2845 ANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSL 2904
G+V Y L + F +D TG + ++LD E + S+ ASD G +
Sbjct: 956 PAGEVRYVLMDGAH-----GTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLAR 1010
Query: 2905 SSTALVSVRVTDINDN--APVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSY 2962
+ V V V D+N+N P FA V++G V+E+ P G V V++ D D S ++ ++ Y
Sbjct: 1011 RTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQD-DDSGLDGELQY 1069
Query: 2963 HITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATD-GLFVTQAMVEV--SV 3019
+ G G A + Q + PLDRE Y+L + A D G ++ EV V
Sbjct: 1070 FLRAGT--GLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEV 1127
Query: 3020 SDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-L 3078
+D NDN P Q + + ED P +L++ A D D S G + +++ FF +
Sbjct: 1128 TDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMI 1187
Query: 3079 DPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLI--LEDVNDNPPVFSSDHY 3136
P +G L T LDRE + L D G +S ++ + DVNDNPP+FS +
Sbjct: 1188 HPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLF 1247
Query: 3137 NTCVYE--NTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLD 3194
N + E + + + R+ A D D G+N +V YS+ DS FSID +G++
Sbjct: 1248 NVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTF- 1306
Query: 3195 REQQSSYNI-SVRATD--QSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSP 3251
YNI +++ATD Q P + L I + P F+ Y TV E T P
Sbjct: 1307 --TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVME-TDP 1363
Query: 3252 GTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVV 3311
++ V + G + I G++ F I TG I ++ LD + L V
Sbjct: 1364 VNHMVGVISVE---GRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTV 1420
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQ 3371
E DG + V I ++N + P+F + Y + +D + G V LL + +D Q
Sbjct: 1421 EVTDGSRTIATQVHIFMI--ANINHHRPQFLETRYEVRVPQDTVPG--VELLRVQAID-Q 1475
Query: 3372 PNGQIHFSIVNGDRD----NEFTVDPVLGLVKVKKKLD-RERVSGYSLLVQAVDSGIPAM 3426
G+ ++G +D + F +DP G++ KLD S ++L V D IP
Sbjct: 1476 DKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIK 1535
Query: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
+ V I + D N + P FT +Y A + + GT +LQ+ D D N +S+
Sbjct: 1536 RNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNA-EVHYSL 1594
Query: 3487 LSGNEEEEFVLDP-HGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEES 3545
L GN E F ++ GI+ A + L V+A+D G PQ + + V
Sbjct: 1595 LKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSD 1654
Query: 3546 THKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQK-SLFKVNSHDGK 3604
P E F+ E G I + A +T+ L+ K +F +NS+ G
Sbjct: 1655 RSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP---SEVTYELREGNKDGVFSMNSYSGL 1711
Query: 3605 IIALGGLDSGK 3615
I LD K
Sbjct: 1712 ISTQKKLDHEK 1722
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 1262 bits (3265), Expect = 0.0
Identities = 1138/3894 (29%), Positives = 1806/3894 (46%), Gaps = 317/3894 (8%)
Query: 81 YRIVSGDEEGFFKAEEVI--IADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDL 138
YRI+ G+E G F+ + + + FL + +KGG L+RE+ Y L+V+ +GE
Sbjct: 174 YRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGG----LDREVTPQYQLLVEVEDKGEPK 229
Query: 139 E-AWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF 197
+ +VN+ V D+ND P+F + Y + E + +SV QV A DAD G+N + Y
Sbjct: 230 RRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRL 289
Query: 198 KNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIE 257
+++ F + P +G+I++ L+++ + +Y L + A+DRG+ ++ A+ + +
Sbjct: 290 QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVP-----SLTGRAEALIQLL 344
Query: 258 RINEHAPTIHV--------VTHVPFSLEKEPTYAVVTVDDLDD-GANGEIESVSIVAGDP 308
+N++ P + V + + A++TV D D ANG I SV I+ G+
Sbjct: 345 DVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNI-SVQILGGNE 403
Query: 309 LDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDK-GSPQ------KCSALKA 361
+ F + K N IK +D E P YNLT+ D G+P + S
Sbjct: 404 -QRHFEVQSSKVPNLSLIKVASALDRERIP-SYNLTVSVSDNYGAPPGAAVQARSSVASL 461
Query: 362 VYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP----IDVEYKLSPGEDA 417
V N D P+ F ++VY V++SE +PPG V+ + + ++ Y + G
Sbjct: 462 VIFVNDINDHPPV-FSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGL 520
Query: 418 VYFKINPRSGLIVTARP--LNTVKKEVYKLEVTNKEGDLK-----AQVTISIEDANDHTP 470
+F I+ SGL+ T L+ L ++ ++ + AQ+ +++ D ND P
Sbjct: 521 GWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKP 580
Query: 471 EFQQPL-YDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI--ASLNLLPFVINQFTGV 527
F QP YD V E+ P GT +L + A+D D G+NG + +S+ A + F ++ +G
Sbjct: 581 VFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGR 640
Query: 528 ISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVI 587
+ST LD E Y +V A+D GSP + S + + + ++NDNSP+F V I
Sbjct: 641 LSTISSLDREEQA-FYSLLVLATDLGSPPQ-SSMARINVSLLDINDNSPVFYPVQYFAHI 698
Query: 588 SYDFPVGGHITAVSAIDID--ELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIK 645
+ P G +IT VSA D D VKY I +G+ F +N SGV+ + +L +
Sbjct: 699 KENEPGGSYITTVSATDPDLGTNGTVKYSISAGDR-SRFQVNAQSGVISTRMALDRE--E 755
Query: 646 NGNFALRITATDGENLADPMS--INISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKAN 703
+ L+I ATDG NL P + I+VL + + FS +VA
Sbjct: 756 KTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFS----QVA-------------- 797
Query: 704 GKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLF 763
YS V E++ +G ++ + A D N + +
Sbjct: 798 ------------YSF---------------VVFENVALGYHVGSVSASTMD--LNSNISY 828
Query: 764 TISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVED 823
I+ G+ F I+ TGQL +DRE Y L + + ++ I V+D
Sbjct: 829 LITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA---SGGTVTGDTMVNITVKD 885
Query: 824 ANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ-FAINSS 882
NDNSP F+Q SVN++E+ G I Q +A D D G NG V YS+ + + FAIN
Sbjct: 886 LNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEK 945
Query: 883 TGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYS 942
G + + LD + +Y ++I A D QL S V L V++ DVND SP F SY
Sbjct: 946 NGTISLLGPLDVHA-GSYQIEILASDMGVP--QLSSSVILTVYVHDVNDNSPVFDQLSYE 1002
Query: 943 VKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEK 1002
V + E PV + ++ D D G G++ Y++ G G + + ELD E
Sbjct: 1003 VTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDREL 1062
Query: 1003 QQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSV 1062
Q Y L V A D+ LS+ V V + DVN+N P F +E R G+ V
Sbjct: 1063 QDRYVLMVVASDRAVE-PLSATVNVTVILEDVNDN--RPLFNSTNYTFYFEEEQRAGSFV 1119
Query: 1063 LQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETM------GSYWL 1116
+V+A D+D G +GE++YS F + SG IT DRE++ +
Sbjct: 1120 GKVSAVDKDFGPNGEVRYSFEMVQP--DFELHAISGEITNTHQFDRESLMRRRGTAVFSF 1177
Query: 1117 TVYATDRGVV-PLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDP 1175
TV ATD+G+ PL V++ ++D+NDNAP + Y + E++ V+++ A D
Sbjct: 1178 TVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDV 1237
Query: 1176 DSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ 1235
D +N + Y I GN + FAI+ +G +T KLD E + L + D G P
Sbjct: 1238 DEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIG-KLDYEATPAYSLVIQAVDSGTIPLN 1296
Query: 1236 STIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSI 1295
ST + + +LDENDN P FP+ + + E R GE + A D D G NA++ YSI
Sbjct: 1297 STCTLNIDILDENDNTPSFPKSTLFVDVLENMRI--GELVSSVTATDSDSGDNADLYYSI 1354
Query: 1296 VDGNDDGKFFIDPKTGMVSSRKQ--FTAGSYDILTIKAVDNGRPQKSSTAR--LHIEWIK 1351
N+ G F I P TG + K+ F S L I A D GRP +SST +H+
Sbjct: 1355 TGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFN 1414
Query: 1352 KPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVG----GNFDS 1404
PPS P + V T ++ V + P N L + I+ GN
Sbjct: 1415 DNPPSFPP----GDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNH-- 1468
Query: 1405 AFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT------NVAVTQVFIKVLDNNDNGP 1458
F ++ GTI +D E +++ ++V+ D A+ V I V D NDN P
Sbjct: 1469 -FTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVP 1527
Query: 1459 EFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVL 1518
F N + + + + I A D DE + + I + F +D +G L
Sbjct: 1528 MFISQNA-LAADPSAVIGSVLTTIMAADPDEG--ANGEIEYEIINGDTDTFIVDRYSGDL 1584
Query: 1519 YTAERLDHEAQDKHILNIMVRDQEF-PYRRNLARVIVNVEDANDHSPYFTNPLYEASVFE 1577
A L + I N++V + P RR + + D P FT P Y + E
Sbjct: 1585 RVASAL---VPSQLIYNLIVSATDLGPERRKSTTELTIILQGLD-GPVFTQPKYITILKE 1640
Query: 1578 SAALGSAVLQVTALDKDKGENAELIYTI-----EAGNTGNMFKIEPVLGIITICKEPDMT 1632
+G+ V+ + A +G A + Y I E G +F I GII D
Sbjct: 1641 GEPIGTNVISIEAASP-RGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDRE 1699
Query: 1633 TMGQFVLSIKVTDQGSPPMSATAIVRISVTMSD-NSHPKFIHKDY-QAEVNENVDIGTSV 1690
L + S T + +T+ D N +P D V EN+ G+ +
Sbjct: 1700 QGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKI 1759
Query: 1691 ILISAI-----SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATN 1745
+ ++A+ + + + Y + G + F I+P SG + + LD ER S Y L+++A +
Sbjct: 1760 MQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADD 1818
Query: 1746 MAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADS 1805
+S+ +NI + D ND+ P F YS + E S+V + I ATD DS
Sbjct: 1819 GL-QSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAA-------ILATDDDS 1870
Query: 1806 NRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAES 1865
N + Y + E F ++ TG LD+E ++ V D G T
Sbjct: 1871 GVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTT--- 1927
Query: 1866 PVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEG 1925
+ V + DVNDNPP+F+ + T L+ VG VL + TD D + +LTYS+ G
Sbjct: 1928 -IRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASG 1986
Query: 1926 -SLDHFLIDSNSGVLTIKN-NNLSKDHYMLIVKVSD------GKFYSTSMVTIMVKEAMD 1977
SL F +D N + +K + S+ Y L+V+V D +F ST+ V+I++ + D
Sbjct: 1987 DSLGQFTVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVND 2046
Query: 1978 SGLHFTQSFYSTSISENNTNITKVAIVNAVG--NRLNEPLKYSILNP-GNKFKIKSTSGV 2034
+ F S T I EN T V A + N ++Y++LNP GNKF I + G
Sbjct: 2047 NPPTFL-SPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGE 2105
Query: 2035 IQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQ 2094
++ TG DREE Y L V A+ + + V V + DINDN+P+F Y +
Sbjct: 2106 VRLTG-ELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEIN 2164
Query: 2095 VDAEPGTLIYQVTAIDKDKGPNGEVTY--VLQDDYGHFEINPNSGNVILKEAFNSDLSNI 2152
+ GT I QV A D D+G NG+V Y V + F I+ +G + + + + + +
Sbjct: 2165 ENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPT 2224
Query: 2153 EYGVTILAKD-GGKPSLSTS-VELPITIVNKAMPVFDKPFYTASVNEDI-RMNTPILSIN 2209
Y +T+ A D G P TS V + + +N +PVF+ Y+ +V E++ + IL +
Sbjct: 2225 -YHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVV 2283
Query: 2210 ATSPE---GQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASD---- 2262
A + + Y++ G+ F + +G L V LD E + L I A+D
Sbjct: 2284 ARDDDRGSNSKLSYVLFGGNEDNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGSP 2342
Query: 2263 ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMV 2322
ALTG T++++V+DVNDN P F Y TT+ E + GT VL V + DAD+ N ++
Sbjct: 2343 ALTGTG---TINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVI 2399
Query: 2323 HYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPS-LSSEVLVH 2381
F I+ S+G I+T+ +LD E + TL V D+G P LSS V
Sbjct: 2400 RI------IGGNSQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVL 2453
Query: 2382 IYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTS 2441
+ ++DVNDNPP F Y +++ G FV V +DAD L YS LSG +
Sbjct: 2454 VTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYS-LSGRNSEK 2512
Query: 2442 FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLF--TSTAQVHIRVLG-ANLYSPAFSQ 2498
F +D G I + E +S++V G F T + V +R + A+ +
Sbjct: 2513 FHIDPLRGAIMAAGPLNGASEVTFSVHVK-DGGSFPKTDSTTVTVRFVNKADFPKVRAKE 2571
Query: 2499 STYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERL 2558
T++ + V++ I + G+P +Y S + N F D+ GQV ++ L
Sbjct: 2572 QTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQL----TGQVSISQPL 2627
Query: 2559 DRENPLEGDVSIFVRALDGGGR--TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRG 2616
D E + +++ A DGG +++ + + V+D NDNAP F + + + ++
Sbjct: 2628 DFEKIQK--YVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPR 2685
Query: 2617 HLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSF 2676
++T V A+D D G N ++ Y + + ++ + I+ G + + ++ K +
Sbjct: 2686 KILT-VSAMDKDSGPNGQLDYEIVNG---NMENSFSINHATGEIRSVRPLDREKVSHYVL 2741
Query: 2677 FVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ 2736
+K+ D G P + + + V I++L P F+Q +S + E++ +G TV R+ S
Sbjct: 2742 TIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQI-FSAHVPENSPLGYTVT--RVTTSD 2798
Query: 2737 N-------VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPL 2789
+S ++ P F I TG I + + L+RE + + +V+A
Sbjct: 2799 EDIGINAISRYSIMDASLP-------FTINPSTGDIVISRPLNREDTDRYRIRVSAH--- 2848
Query: 2790 DKVDIVFTV--DVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANG 2847
D +TV DV I V D+NDN P F +SY E +G+K+TQV A D D G+NG
Sbjct: 2849 ---DSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNG 2905
Query: 2848 QVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFT--------FSVVASDLG 2899
QV Y + S S E F I++ TG I + L ++ F+ F V +SD G
Sbjct: 2906 QVFYFIKSQS------EYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRG 2959
Query: 2900 EAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQ 2959
+ SL S V++ + D NDNAP F + Y V ++ G + ++ D +N +
Sbjct: 2960 KP-SLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSE 3018
Query: 2960 VSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDG---LFVTQAMVE 3016
V Y I+ N G+F L + W + V L + +F+ +TA D +QA V
Sbjct: 3019 VEYFISNDNHLGKFKLDN-DTGW-ISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVH 3076
Query: 3017 VSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSE- 3075
++V++ N ++P Q +A +PE I+ VSA+D D NG I+YS+ SGN E
Sbjct: 3077 ITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSI-SSGNEEG 3135
Query: 3076 -FFLDPESGELKTLALLDRERIPVYSLMAKATDGGG----RFCQSNIHLILEDVNDNPPV 3130
F ++ +G L LD E + + A DGG +C +++I DVNDN PV
Sbjct: 3136 IFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVI--DVNDNSPV 3193
Query: 3131 FSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILE 3190
F SD Y V EN + + + A D D G N + Y++ S +F ID ++G+I +
Sbjct: 3194 FLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQ 3253
Query: 3191 QPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTS 3250
LD E + SY+++V+A + P + S TV I + N+ P F + Y + E
Sbjct: 3254 GFLDFETKQSYHLTVKAFNV-PDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAP 3312
Query: 3251 PGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLV 3310
GT V VFA+ +D+GT+ E+ YLI + + F+IN KTG I VS +LD E +R L
Sbjct: 3313 KGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLK 3372
Query: 3311 VEAKDGGTPALSAV--ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDV 3368
V AK+ G+ + + TVN+ + D ND PP F+ ++YS ISE +G V + A D
Sbjct: 3373 VLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDS 3431
Query: 3369 DSQPN-GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMS 3427
DS P+ + + I +G+ + F+++P G + V +LDRE + Y+L V AVDSG P+ +
Sbjct: 3432 DSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSAT 3491
Query: 3428 STATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSIL 3487
+A++ + + D+NDN P+ T + + ENK GT ++ L TD D N PF++ +L
Sbjct: 3492 GSASLLVTLEDINDNGPMLTVSE--GEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLL 3549
Query: 3488 S-GNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEEST 3546
S G F L G+L + + ++ L V KDSG PQ S + + VI+++
Sbjct: 3550 STGPATSYFSLSTAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQND 3609
Query: 3547 HKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNSHDGKII 3606
+ + +EIF+ + FPGG++G + D D+ D +L S SLF + +
Sbjct: 3610 NPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLDSFHCSLTSGVTSLFSIPGGTCDLN 3669
Query: 3607 ALGGLDSGKYVLNVSVSDG-RFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPEDFVGLH 3665
+ G + L V +DG V ++ V + + N++ +R + +DF+ H
Sbjct: 3670 SQPRSTDGTFDLTVLSNDGVHSTVTSNIRVFFAGFSNATVDNSILLRLGVPTVKDFLTNH 3729
Query: 3666 MHGFRRTLRNAVLTQKQDSLRIISIQPVAGTNQLDMLFAVEMHSSEFYKPAYLIQKLSNA 3725
F R + ++ LT ++++ S N+ +L AV+ + +++ P+ + +
Sbjct: 3730 YLHFLR-IASSQLTGLGTAVQLYS--AYEENNRTFLLAAVKRNHNQYVNPSGVATFFESI 3786
Query: 3726 RRHLENIMRISAILEKNCSGLDCQEQHCEQGLS-----LDSHALMTYSTARISFVCPRFY 3780
+ E ++R S + ++ C C+ G S S L + + + V
Sbjct: 3787 K---EILLRQSGVKVESVDHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPL 3843
Query: 3781 RNVRCTC----NGGLCPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLG 3830
+ C C G C D C+ PC C + F C CP G G
Sbjct: 3844 QPFLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGG---FSCSCPDGFTG 3894
Score = 1132 bits (2929), Expect = 0.0
Identities = 1011/3341 (30%), Positives = 1561/3341 (46%), Gaps = 247/3341 (7%)
Query: 385 ISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLN--TVKKEV 442
+ E PPG +V ++ P Y+LS E F IN +G + T ++ ++ +V
Sbjct: 51 VLEEQPPGTLVGTIQTRP---GFTYRLS--ESHALFAINSSTGALYTTSTIDRESLPSDV 105
Query: 443 YKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKG 502
L V + +V + + D ND+ P F P E G V+ +A+D D G
Sbjct: 106 INLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIG 165
Query: 503 ENG--YITYSI----------ASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRAS 550
NG + +Y I + L P F ++S LD E +P+ Y+ +V
Sbjct: 166 SNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVS-KGGLDREVTPQ-YQLLVEVE 223
Query: 551 DWGSPYRH-ESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELE 609
D G P R +VNVT++ ++NDN P+F Q + D VG + V+A D DE
Sbjct: 224 DKGEPKRRGYLQVNVTVQ--DINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGT 281
Query: 610 LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINI 669
+ +E F ++P++G++ +++ L + ++L + A D +
Sbjct: 282 NADIRYRLQDEGTPFQMDPETGLITVREPLDFEARR--QYSLTVQAMDR---------GV 330
Query: 670 SVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSF 729
L G+ A+ L + L +N D + F Y
Sbjct: 331 PSLTGR-------------AEALIQLL--------DVNDNDPVVKFRYFPATSRY----- 364
Query: 730 PSDVAVKEDLPVGANILKIKAYDADS-GFNGKVLFTISDGNTDSCFNIDM----ETGQLK 784
+V E+ VG + + DADS NG + I GN F + +K
Sbjct: 365 ---ASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIK 421
Query: 785 VLMPMDREHTDLYLLNITIYD-LGNP------QKSSWRLLTINVEDANDNSPVFIQDSYS 837
V +DRE Y L +++ D G P +SS L I V D ND+ PVF Q Y
Sbjct: 422 VASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYR 481
Query: 838 VNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDT--QQFAINSSTGIVYVADQ--LD 893
VN+ E + G+ + + A D D G N + YS+++ F I+ +G+V LD
Sbjct: 482 VNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLD 541
Query: 894 RESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI-PSSYSVKVLEDLPVG 952
RE + L I ARD+ + S L V L DVND P F P Y V V+E+ P G
Sbjct: 542 RELASQIVLNISARDQGVHPK--VSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTG 599
Query: 953 TVIAWLETHDPDLGLGGQVRYSLVNDYNGR--FEIDKASGAIRLSKELDYEKQQFYNLTV 1010
T + L D DLG G VR+SL R F +D SG + LD E+Q FY+L V
Sbjct: 600 TELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLV 659
Query: 1011 RAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDE 1070
A D G P SS++ + V ++D+N+N +P F +KEN G+ + V+A D
Sbjct: 660 LATDLGSPPQ-SSMARINVSLLDINDN--SPVFYPVQYFAHIKENEPGGSYITTVSATDP 716
Query: 1071 DSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYS 1130
D G +G ++YSI G RF ++ +SGVI+ LDRE +Y L + ATD G + +
Sbjct: 717 DLGTNGTVKYSISAGD-RSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPN 775
Query: 1131 TIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSG 1190
V I V D DN P+ S+ Y VV EN V + A D +SN ++Y IT+G
Sbjct: 776 QAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSN--ISYLITTG 833
Query: 1191 NPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDN 1250
+ + FAIN TG + TT+ +DRE+Q+ + L+V V GG + + + V+ D NDN
Sbjct: 834 DQKGMFAINQVTGQL-TTANVIDREEQSFYQLKV-VASGGTVTGDTMVNITVK--DLNDN 889
Query: 1251 KPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKT 1310
P F + + + + E + G I++A A D DEG N + YS+ N F I+ K
Sbjct: 890 SPHFLQAIESVNVVE--NWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKN 946
Query: 1311 GMVS--SRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN 1368
G +S AGSY I I A D G PQ SS+ L + SP+ FD+ Y
Sbjct: 947 GTISLLGPLDVHAGSYQI-EILASDMGVPQLSSSVILTVYVHDVNDNSPV---FDQLSYE 1002
Query: 1369 FTVMESDRVTEIVGVVSVQP----ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAE 1424
T+ ES+ V V AN + + I GN AF G + I LD E
Sbjct: 1003 VTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRE 1061
Query: 1425 QRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQ 1481
+ Y + V +D A V + + D NDN P F+ NY E+ + + +
Sbjct: 1062 LQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGK 1121
Query: 1482 IEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKH------ILN 1535
+ A D+D + V S + + F + +G + + D E+ +
Sbjct: 1122 VSAVDKD--FGPNGEVRYSFEMV-QPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFT 1178
Query: 1536 IMVRDQEFPY-RRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKD 1594
++ DQ P ++ A V V ++D ND++P F Y+A++ ESAA + VL+V+A D D
Sbjct: 1179 VIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVD 1238
Query: 1595 KGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSAT 1654
+G N + Y+I GN F I+ G +T+ + D + L I+ D G+ P+++T
Sbjct: 1239 EGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNST 1298
Query: 1655 AIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST-----LIYEVKDGD 1709
+ I + +++ P F +V EN+ IG V ++A + L Y + +
Sbjct: 1299 CTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTN 1358
Query: 1710 INGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMA--GMASNATVNIQIVDENDNAP 1767
+G F+I+P +G I K LD+E S Y+L I A + +S +V I + D NDN P
Sbjct: 1359 NHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPP 1418
Query: 1768 VFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAK-KFFTV 1826
F S+ E PI + V S + A D D++ N L Y I++ + FT+
Sbjct: 1419 SFPPGDIFKSIVENIPIGTSVIS-------VTAHDPDADINGQLSYTIIQQMPRGNHFTI 1471
Query: 1827 DSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVE-VNIEVTDVNDNPPVFTQ 1885
D G I T A +D E F V D P T ++ V I VTD+NDN P+F
Sbjct: 1472 DEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFIS 1531
Query: 1886 AVFETILLLPT-YVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKNN 1944
+ P+ +G + + A DPD E+ Y ++ G D F++D SG L + +
Sbjct: 1532 Q--NALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASA 1589
Query: 1945 NL-SKDHYMLIVKVSD---GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITK 2000
+ S+ Y LIV +D + ST+ +TI++ + +D G FTQ Y T + E T
Sbjct: 1590 LVPSQLIYNLIVSATDLGPERRKSTTELTIIL-QGLD-GPVFTQPKYITILKEGEPIGTN 1647
Query: 2001 VAIVNAVGNRLNE-PLKYSILN-------PGNKFKIKSTSGVIQTTGVPFDREEQELYEL 2052
V + A R +E P++Y I++ G F I +G+IQT + DRE+ L
Sbjct: 1648 VISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAI-LDREQGACLYL 1706
Query: 2053 V----VEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTA 2108
V +E S R R V + ++DINDN PVF V+ + G+ I Q+TA
Sbjct: 1707 VDVYAIEKSTAFP--RTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTA 1764
Query: 2109 IDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPS 2167
+D D+G N VTY ++ F I+P SG++I + + + +Y + + A DG + S
Sbjct: 1765 MDADEGANALVTYTIISGADDSFRIDPESGDLIATRRLDRERRS-KYSLLVRADDGLQSS 1823
Query: 2168 LSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE---GQGIIYIIID 2224
+ + ++ VN P F +P Y+ + ED + + +I AT + I YI+ +
Sbjct: 1824 -DMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNE 1882
Query: 2225 GDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNP 2284
D F ++ TGV + LDYEV Y LT+RA D G + V + DVNDNP
Sbjct: 1883 DDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDG-GGQFTTIRVYFNILDVNDNP 1941
Query: 2285 PIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSG 2344
PIF +Y+T+L E +G+ VL DAD N + Y I +S F +D +G
Sbjct: 1942 PIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASG--DSLGQFTVD-KNG 1998
Query: 2345 LILTARMLDHELVQHCTLKVRSID-SGFPS--LSSEVLVHIYISDVNDNPPVFNQLIYES 2401
++ + LD E L V+ D P+ +S V I + DVNDNPP F +
Sbjct: 1999 VLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKL-T 2057
Query: 2402 YVSELAPRGHFVTCVQASDADSSDFDRLEYSILS--GNDRTSFLMDSKSGVITLSNHRKQ 2459
Y+ E P V QA+D DS +EY++L+ GN F + + G + L+ +
Sbjct: 2058 YIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGN---KFSIGTIDGEVRLTGELDR 2114
Query: 2460 RMEPLYSLNVSVSD---GLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI 2516
Y+L V +D +S+ +V + VL N +P F+Q+ Y E+ EN GT +I
Sbjct: 2115 EEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDII 2174
Query: 2517 HVRATDGDPGTYGQISYAIINDFAKDRFLIDS-NGQVITTERLDRENPLEGDVSIFVRAL 2575
V A DGD GT GQ+ Y I+N F IDS G + + LDRE + V+A
Sbjct: 2175 QVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREK--TPTYHLTVQAT 2232
Query: 2576 DGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGR-GHLVTQVQAIDPDDGAN 2632
D G RT TV ++++D ND P F Y +V ++G + QV A D D G+N
Sbjct: 2233 DRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSN 2292
Query: 2633 SRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLI 2692
S+++Y L+ + A L + G VT+ + K + + A D G P
Sbjct: 2293 SKLSYVLFG-GNEDNAFTLSASGELG--VTQSLDRETKERFV-LMITATDSGSPALTGTG 2348
Query: 2693 PVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRIL---PSQNVWFSTVNGERPE 2749
+ + V +P+F Y TI ED G+ V + S+N + G
Sbjct: 2349 TINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGNSQ- 2407
Query: 2750 NNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLND 2809
F I TG I LDRET + V + + + V + V D+ND
Sbjct: 2408 ------FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVND 2461
Query: 2810 NKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNID 2869
N P F+ Y T I G+ + V D D G N ++ YSL + E F+ID
Sbjct: 2462 NPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNS-----EKFHID 2516
Query: 2870 SNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVY 2929
G I L+ ++ TFSV D G +F + + V+VR + D V A+E
Sbjct: 2517 PLRGAIMAAGPLNGASE--VTFSVHVKD-GGSFPKTDSTTVTVRFVNKADFPKVRAKE-- 2571
Query: 2930 RGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRP 2989
P + V+ L T +S +SY+I GN F + Q +V + +P
Sbjct: 2572 ---QTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQID--QLTGQVSISQP 2626
Query: 2990 LDREEQDIYFLNITATDG---LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
LD E+ Y + I A DG F + ++++V DVNDN+P+ + + + + E++ K
Sbjct: 2627 LDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRK 2686
Query: 3047 IILKVSAKDADIGSNGYIRYSLY-GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKA 3105
IL VSA D D G NG + Y + G+ + F ++ +GE++++ LDRE++ Y L K+
Sbjct: 2687 -ILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKS 2745
Query: 3106 TDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGIN 3163
+D G +++ +++ D NDN P F S ++ V EN+ +TRV D DIGIN
Sbjct: 2746 SDKGSPSQSTSVKVMINILDENDNAPRF-SQIFSAHVPENSPLGYTVTRVTTSDEDIGIN 2804
Query: 3164 RKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVT 3223
YS+ D A F+I+ S+G I++ +PL+RE Y I V A D G ++S T VT
Sbjct: 2805 AISRYSIMD-ASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDS--GWTVS--TDVT 2859
Query: 3224 ITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGK 3283
I V DINDN P F R Y + PE T G++V VFAT D G+N ++ Y I+S +E
Sbjct: 2860 IFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEY-- 2917
Query: 3284 FKINPKTGGISVSEVLDYE--------LCKRFYLVVEAKDGGTPALSAVATVNINLTDVN 3335
F+IN TG I ++L Y+ R +V + D G P+L + TV IN+ D N
Sbjct: 2918 FRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSN 2977
Query: 3336 DNPPKFSQDVYSAVISEDALVGDSVILLIA-EDVDSQPNGQIHFSIVNGDRDNEFTVDPV 3394
DN P+F + Y ++++ VG +I + A +D D N ++ + I N + +F +D
Sbjct: 2978 DNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDND 3037
Query: 3395 LGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAV 3454
G + V L + + + V A D G P +SS ATV+I +++ N ++P F+ ++ +A
Sbjct: 3038 TGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSAT 3097
Query: 3455 IQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH-GILRSAVVFQHTE 3513
I E+ +G+ + + DRD+ NG +SI SGNEE F ++ GIL A +
Sbjct: 3098 IPESHSIGSIVRTVSARDRDAAMNG-LIKYSISSGNEEGIFAINSSTGILTLAKALDYEL 3156
Query: 3514 SLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKI 3573
++ + + A D G + + + V VI+ + + P + + F +E+ G + +
Sbjct: 3157 CQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHL 3216
Query: 3574 HATDQD--MYDVLTFALKSEQKSLFKVNSHDGKIIALGGLD 3612
+ATD D V+ + ++S LF ++ + G I G LD
Sbjct: 3217 NATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLD 3257
Score = 1082 bits (2797), Expect = 0.0
Identities = 961/3308 (29%), Positives = 1541/3308 (46%), Gaps = 250/3308 (7%)
Query: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLID----LSWDIKYRIVSGDEEGFFKAEEVI 98
F+ +Y + E + +YV+ GI+ D L+ +++Y IVSG+ G+F
Sbjct: 475 FSQQVYRVNLSEEAPPGSYVS-----GISATDGDSGLNANLRYSIVSGNGLGWFH----- 524
Query: 99 IADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRG-EDLEAWTKVNIQVLDMNDLRPL 157
I++ L G+S L+RE+ +L + +G ++ ++ + +LD+ND +P+
Sbjct: 525 ISEHSGL---VTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPV 581
Query: 158 FS-PTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
FS P Y V++ E+ P T + + ATD D+G NG + + F + P SG +
Sbjct: 582 FSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRL 641
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
S L+ +E+ Y L +LA D G+ SS A++ V + IN+++P + V +
Sbjct: 642 STISSLDREEQAFYSLLVLATD-----LGSPPQSSMARINVSLLDINDNSPVFYPVQYFA 696
Query: 274 FSLEKEPTYAVVT---VDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
E EP + +T D D G NG ++ SI AGD A+ G I R
Sbjct: 697 HIKENEPGGSYITTVSATDPDLGTNGTVK-YSISAGDRSRFQVNAQSG------VISTRM 749
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
+D E Y L + A D G+ Q + T+D P+ F + Y + E
Sbjct: 750 ALDREE-KTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPV-FSQVAYSFVVFENVA 807
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT 448
G V V S + ++ Y ++ G+ F IN +G + TA ++ ++ Y+L+V
Sbjct: 808 LGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVV 867
Query: 449 NKEGDL--KAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
G + V I+++D ND++P F Q + V E+ G S+ A D D+G NG
Sbjct: 868 ASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGM 927
Query: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTI 566
+ YS+ F IN+ G IS LD + Y+ + ASD G P + S V +T+
Sbjct: 928 VLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGS--YQIEILASDMGVP-QLSSSVILTV 984
Query: 567 RIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELGFF 624
+ +VNDNSP+F++++ + +S PV V A D D + Y I GN F
Sbjct: 985 YVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAF 1044
Query: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCR 684
+ PD G L +K L + L + A+D +P+S ++V
Sbjct: 1045 GIFPD-GQLYIKSELDRE--LQDRYVLMVVASD--RAVEPLSATVNV------------- 1086
Query: 685 ETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGAN 744
+ LED +N P F+ S +E+ G+
Sbjct: 1087 --------------------TVILED-------VNDNRPLFN-STNYTFYFEEEQRAGSF 1118
Query: 745 ILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREH------TDLYL 798
+ K+ A D D G NG+V ++ D F + +G++ DRE T ++
Sbjct: 1119 VGKVSAVDKDFGPNGEVRYSFEMVQPD--FELHAISGEITNTHQFDRESLMRRRGTAVFS 1176
Query: 799 LNITIYDLGNPQK-SSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARD 857
+ D G PQ + + ++D NDN+P F++D Y I ES+ T++++V A D
Sbjct: 1177 FTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASD 1236
Query: 858 KDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQ 915
D G+NG + YS++ + +QFAI+S++G V + +LD E+ YSL I+A D
Sbjct: 1237 VDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTI--P 1294
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSL 975
L S TL + + D ND +P+F S+ V VLE++ +G +++ + D D G + YS+
Sbjct: 1295 LNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSI 1354
Query: 976 VNDYN-GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDV 1034
N G F I +G+I L+K+LD+E Q Y L + AKD+GRP S++S V + V D
Sbjct: 1355 TGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVV-IHVRDF 1413
Query: 1035 NENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLG-RFSI 1093
N+N P FP + S+ EN IGTSV+ VTA D D+ +G++ Y+I G F+I
Sbjct: 1414 NDN--PPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTI 1471
Query: 1094 DDESGVITAADILDRETMGSYWLTVYATDRGV---VPLYSTIEVYIEVEDVNDNAPLTSE 1150
D+ G I +DRE + LTV A D+ V Y+ V I V D+NDN P+
Sbjct: 1472 DEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFIS 1531
Query: 1151 PIYYPVVMENSPKDVSVI-QIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS 1209
+ + S SV+ I A DPD +N ++ Y I +G+ F ++ +G + S
Sbjct: 1532 --QNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFI-VDRYSGDLRVAS 1588
Query: 1210 RKLDREQQAEHFLEVTVTDGGPSPKQST--IWVVVQVLDENDNKPQFPEKVYQIKLPERD 1267
+ Q + L V+ TD GP ++ST + +++Q LD P F + Y L
Sbjct: 1589 ALV--PSQLIYNLIVSATDLGPERRKSTTELTIILQGLD----GPVFTQPKYITIL---- 1638
Query: 1268 RKKRGEPI---YRAFAFDRDEGPNAEISYSIVDGNDDGK-----FFIDPKTGMVSSR--- 1316
K GEPI + G A + Y IV + K F I TG++ +
Sbjct: 1639 --KEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAIL 1696
Query: 1317 -KQFTAGSY--DILTI-KAVDNGRPQKSSTARLHIEWIKKPPPSP---IPLTFDEPFYNF 1369
++ A Y D+ I K+ R Q++ + PP P + LT +E
Sbjct: 1697 DREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEE----- 1751
Query: 1370 TVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIY 1429
+ + ++ ++ + + + AN + + I+ G D +F + G ++ + LD E+RS Y
Sbjct: 1752 NIGDGSKIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRRLDRERRSKY 1810
Query: 1430 NMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
++ V DG + ++ I V D ND+ P+FS+P Y I ED +P + + I ATD D
Sbjct: 1811 SLLVRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDS 1870
Query: 1490 --KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
+++Y V+ + F ++P TGV LD+E Q +IL + D +
Sbjct: 1871 GVNGEITYIVNEDDED---GIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQF-- 1925
Query: 1548 NLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEA 1607
RV N+ D ND+ P F+ Y S+ E+ +GS VL D D G N++L Y+I +
Sbjct: 1926 TTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIAS 1985
Query: 1608 GNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSA-TAIVRISVTMSD- 1665
G++ F ++ G++ + K D + + L ++V D P S T+ ++S+ + D
Sbjct: 1986 GDSLGQFTVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDV 2044
Query: 1666 NSHPKFIHKDYQAEVNENVDIGTSVILISAI----SQSTLIYEVKDGDINGIFTINPYSG 1721
N +P + EN I T V A ++ I + F+I G
Sbjct: 2045 NDNPPTFLSPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDG 2104
Query: 1722 VITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDENDNAPVFLFSQYSGSLS 1779
+ LD E S+Y L + AT+ ++S+ V + ++D NDN P+F + Y ++
Sbjct: 2105 EVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEIN 2164
Query: 1780 EAAPINSIVRSLDNSPLV-IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIAN 1838
E +L + ++ + A D D N + Y IV + F +DS TGAI
Sbjct: 2165 E--------NTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKP 2216
Query: 1839 LDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYV 1898
LD E +H V D GS T S V+I + D+ND PVF + + + +P +
Sbjct: 2217 LDREKTPTYHLTVQATDRGSTPRTDTS--TVSIVLLDINDFVPVFELSPYS--VNVPENL 2272
Query: 1899 GV---EVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKN--NNLSKDHYML 1953
G +L+V A D D +L+Y L G+ D+ S SG L + + +K+ ++L
Sbjct: 2273 GTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVL 2332
Query: 1954 IVKVSDG---KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNR 2010
++ +D T + ++V + D+ F Y T+I E+ T V +VNA
Sbjct: 2333 MITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDAD 2392
Query: 2011 LNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEAS-RELDHLRVARVV 2069
++ I+ ++F I ++G I T+ + DRE ++ Y LVV S +
Sbjct: 2393 ASKNAVIRIIGGNSQFTINPSTGQIITSAL-LDRETKDNYTLVVVCSDAGSPEPLSSSTS 2451
Query: 2070 VRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQD-DYG 2128
V V + D+NDN P F PY + PG+ ++ VT D D GPN E+ Y L +
Sbjct: 2452 VLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSE 2511
Query: 2129 HFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKA-MPVFD 2187
F I+P G ++ N S + + V + KDGG + S + + VNKA P
Sbjct: 2512 KFHIDPLRGAIMAAGPLNG-ASEVTFSVHV--KDGGSFPKTDSTTVTVRFVNKADFPKVR 2568
Query: 2188 KPFYTASVNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLD 2247
T E+ +++ + +I +S G+ + Y I G+ F ID TG + + PLD
Sbjct: 2569 AKEQTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLD 2628
Query: 2248 YEVTSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPV 2306
+E Y + I A D + +D+ V DVNDN PIF + + + + E +L +
Sbjct: 2629 FEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILE-NLSPRKI 2687
Query: 2307 LQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRS 2366
L V ++D DS N + Y+IV N + F I+ ++G I + R LD E V H L ++S
Sbjct: 2688 LTVSAMDKDSGPNGQLDYEIVNG--NMENSFSINHATGEIRSVRPLDREKVSHYVLTIKS 2745
Query: 2367 IDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDF 2426
D G PS S+ V V I I D NDN P F+Q I+ ++V E +P G+ VT V SD D
Sbjct: 2746 SDKGSPSQSTSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGIN 2804
Query: 2427 DRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRV 2486
YSI+ + F ++ +G I +S + Y + VS D +T + V I V
Sbjct: 2805 AISRYSIMDAS--LPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFV 2862
Query: 2487 LGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLI 2546
N +P FS+++Y + E G+KV V ATD D G+ GQ+ Y I + + F I
Sbjct: 2863 TDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQ--SEYFRI 2920
Query: 2547 D-SNGQVITTERLDRENPLE-GDVSI----FVRALDGGGRTTF---CTVRVIVVDENDNA 2597
+ + G++ + L +N +V+I F+ G+ + TV + +VD NDNA
Sbjct: 2921 NATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNA 2980
Query: 2598 PQFMTVEYRASVRADVGRGHLVTQVQAIDPDD-GANSRITYSLYSEASVSVADLLEIDPD 2656
PQF+ +Y V +V G + +V AID D G NS + Y + ++ + ++D D
Sbjct: 2981 PQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLG---KFKLDND 3037
Query: 2657 NGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFT 2716
GW+ + N V A D G P S V+I V P F+QS S T
Sbjct: 3038 TGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSAT 3097
Query: 2717 IAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETS 2776
I E +IGS V T+ + N+ GIF I TG + L K LD E
Sbjct: 3098 IPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELC 3157
Query: 2777 PAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQV 2836
++A I V V + V+D+NDN PVF + Y ++E P GT + +
Sbjct: 3158 QKHEMTISA-IDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHL 3216
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
A D D G N + Y++ S + F ID NTG I+T LD ET ++ +V A
Sbjct: 3217 NATDADSGTNAVIAYTVQSSDS-----DLFVIDPNTGVITTQGFLDFETKQSYHLTVKAF 3271
Query: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
++ + S A V++++ N+ P F ++Y + E+ P G +V + DRD
Sbjct: 3272 NVPDE-ERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLG-T 3329
Query: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATD-----GLFVT 3011
+ +V Y I G + + F + + ++YV LDRE+++ L + A + G +
Sbjct: 3330 DGEVHYLIFGNSRKKGFQIN--KKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADID 3387
Query: 3012 QAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLY-G 3070
+ V V+V D ND P+ Y+ + E +P + VSA D+D + R+S + G
Sbjct: 3388 EVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSD-SIPSWSRFSYFIG 3445
Query: 3071 SGNSE--FFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLI--LEDVND 3126
SGN F ++P++G++ A LDRE +P+Y+L A D G + L+ LED+ND
Sbjct: 3446 SGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDIND 3505
Query: 3127 NPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRK--VVYSLADSAGGVFSIDSSS 3184
N P+ + V EN L+ +Q+ DPD+ N+ Y L+ + S++
Sbjct: 3506 NGPMLTVSEGE--VMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTA 3563
Query: 3185 GIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVT 3244
G++ + +DREQ + + +SV D Q +SS TV ITV+D NDNP + V
Sbjct: 3564 GVLSTTREIDREQIADFYLSVVTKDSGVPQ-MSSTGTVHITVIDQNDNPSQSRTVEIFVN 3622
Query: 3245 VPEDTSPG 3252
+ PG
Sbjct: 3623 YYGNLFPG 3630
Score = 1063 bits (2750), Expect = 0.0
Identities = 1012/3578 (28%), Positives = 1615/3578 (45%), Gaps = 298/3578 (8%)
Query: 142 TKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--- 198
T+V + V D+ND P+F + VT E + V TATD+DIGSNG + ++
Sbjct: 119 TEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIR 178
Query: 199 -NKVDLFSVHPT---SGV-----ISLSGRLNYDEKNRYDLEILAVDRG-MKLYGNNGVSS 248
N+ F + T SG + G L+ + +Y L + D+G K G V+
Sbjct: 179 GNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNV 238
Query: 249 TAKLYVHIERINEHAPTI---HVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVA 305
T ++ IN++ P H VP + V D D+G N +I
Sbjct: 239 T------VQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDE 292
Query: 306 GDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIG 365
G P F + E I R+ +D+E+ Y+LT+QA D+G P +A+
Sbjct: 293 GTP---FQMDPE-----TGLITVREPLDFEA-RRQYSLTVQAMDRGVPSLTGRAEALIQL 343
Query: 366 NPTRDTVPI----RFEKEVYDVSISEFSPPGVVVAIVKLSPEPI-----DVEYKLSPGED 416
D P+ F S+ E + G VVA++ ++ ++ ++ G +
Sbjct: 344 LDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNE 403
Query: 417 AVYFKIN----PRSGLIVTARPLNTVKKEVYKLEVTNKEG------------DLKAQVTI 460
+F++ P LI A L+ + Y L V+ + A + I
Sbjct: 404 QRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVI 463
Query: 461 SIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-F 519
+ D NDH P F Q +Y ++E P G+ V +SA+D D G N + YSI S N L F
Sbjct: 464 FVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWF 523
Query: 520 VINQFTGVISTTEE--LDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPL 577
I++ +G+++T LD E + +I + A D G + S + + + +VND P+
Sbjct: 524 HISEHSGLVTTGSSGGLDRELASQIV-LNISARDQG-VHPKVSYAQLVVTLLDVNDEKPV 581
Query: 578 FEKVACQGV-ISYDFPVGGHITAVSAIDID--ELELVKYKIISG-NELGFFYLNPDSGVL 633
F + V + + P G + + A D D + V++ + + F L+P SG L
Sbjct: 582 FSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRL 641
Query: 634 QLKKSLTNSGIKNGNFALRITATD-GENLADPMS-INISVLHGKVSSKSFSCRETRVAQK 691
SL + ++L + ATD G M+ IN+S+
Sbjct: 642 STISSLDRE--EQAFYSLLVLATDLGSPPQSSMARINVSL-------------------- 679
Query: 692 LAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAY 751
L++ D FY + YF +KE+ P G+ I + A
Sbjct: 680 --------------LDINDNSPVFYPVQ----YF-------AHIKENEPGGSYITTVSAT 714
Query: 752 DADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQK 811
D D G NG V ++IS G+ S F ++ ++G + M +DRE Y L I D GN Q
Sbjct: 715 DPDLGTNGTVKYSISAGDR-SRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQS 773
Query: 812 SSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL 871
+ ++TI V D DN PVF Q +YS + E+ +G + V A DL SN ++Y +
Sbjct: 774 PNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSN--ISYLIT 831
Query: 872 TDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDV 929
T Q+ FAIN TG + A+ +DRE ++ Y LK+ A +G + ++ + D+
Sbjct: 832 TGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGDTMVNIT-----VKDL 886
Query: 930 NDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKAS 989
ND SP F+ + SV V+E+ G I + DPD G+ G V YSL + F I++ +
Sbjct: 887 NDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKN 946
Query: 990 GAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVV 1049
G I L LD Y + + A D G P LSS + V V DVN+N +P F +
Sbjct: 947 GTISLLGPLDVHAGS-YQIEILASDMGVP-QLSSSVILTVYVHDVNDN--SPVFDQLSYE 1002
Query: 1050 GSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRE 1109
++ E+ + + +V A D+DSG +GEI Y+I +G+ F I + G + LDRE
Sbjct: 1003 VTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRE 1061
Query: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQ 1169
Y L V A+DR V PL +T+ V + +EDVNDN PL + Y E V +
Sbjct: 1062 LQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGK 1121
Query: 1170 IQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEH-------FL 1222
+ A D D N ++ Y P F ++ +G IT T + DRE F
Sbjct: 1122 VSAVDKDFGPNGEVRYSFEMVQPD--FELHAISGEITNT-HQFDRESLMRRRGTAVFSFT 1178
Query: 1223 EVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFD 1282
+ G P P + V V + D NDN P+F + YQ + E + R A D
Sbjct: 1179 VIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANL--TQVLRVSASD 1236
Query: 1283 RDEGPNAEISYSIVDGNDDGKFFIDPKTGMVS--SRKQFTAGSYDILTIKAVDNGRPQKS 1340
DEG N I YSI+ GN++ +F ID +G V+ + + A L I+AVD+G +
Sbjct: 1237 VDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLN 1296
Query: 1341 STARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPA----NTPLWFD 1396
ST L+I+ + + +P +F + V+E+ R+ E+V V+ + N L++
Sbjct: 1297 STCTLNIDILDENDNTP---SFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYS 1353
Query: 1397 IVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD---GTNVAVTQVFIKVLDN 1453
I G N F G+I +AK LD E +S+Y +++ D + V I V D
Sbjct: 1354 ITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDF 1413
Query: 1454 NDNGPEFSQPNYDVTISEDVLPDTEILQIEA--TDRDEKHKLSYTVHSSIDSISMRKFRI 1511
NDN P F + +I E++ T ++ + A D D +LSYT+ + F I
Sbjct: 1414 NDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMP--RGNHFTI 1471
Query: 1512 DPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPY---RRNLARVIVNVEDANDHSPYFTN 1568
D G +YT +D E + L + DQ P R L V + V D ND+ P F +
Sbjct: 1472 DEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFIS 1531
Query: 1569 PLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE 1628
+ SA +GS + + A D D+G N E+ Y I G+T + F ++ G + +
Sbjct: 1532 Q-NALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDT-DTFIVDRYSGDLRVA-- 1587
Query: 1629 PDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGT 1688
Q + ++ V+ P + +++ + P F Y + E IGT
Sbjct: 1588 -SALVPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGT 1646
Query: 1689 SVILISAI----SQSTLIYEV-----KDGDINGIFTINPYSGVITTQKALDYERTSSYQL 1739
+VI I A S++ + Y + ++ + +FTI ++G+I T LD E+ + L
Sbjct: 1647 NVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYL 1706
Query: 1740 I----IQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSP 1795
+ I+ + A V I + D NDN PVF ++ E S + L
Sbjct: 1707 VDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQL---- 1762
Query: 1796 LVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRD 1855
A DAD NAL+ Y I+ S A F +D +G + LD E + + V D
Sbjct: 1763 ---TAMDADEGANALVTYTII-SGADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADD 1818
Query: 1856 SGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVP 1915
S + +NI V+DVND+ P F++ V+ + T G V + ATD DS V
Sbjct: 1819 G-----LQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVN 1873
Query: 1916 PELTYSLMEGSLDH-FLIDSNSGV--LTIKNNNLSKDHYMLIVKVSD-GKFYSTSMVTIM 1971
E+TY + E D F ++ +GV LT + + +Y+L V+ D G ++T V
Sbjct: 1874 GEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFN 1933
Query: 1972 VKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNA--VGNRLNEPLKYSILNPGNKFKIK 2029
+ + D+ F+ + YSTS+ EN + V + N + +N L YSI + + +
Sbjct: 1934 ILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFT 1993
Query: 2030 STSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVV----VRVNIEDINDNSPVFV 2085
+ DRE Q Y LVV+ +L + +R V + + D+NDN P F+
Sbjct: 1994 VDKNGVLKVLKALDRESQSFYNLVVQV-HDLPQIPASRFTSTAQVSIILLDVNDNPPTFL 2052
Query: 2086 GLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGH-FEINPNSGNVILK-E 2143
P + + T++++ A D D GPN + Y L + G+ F I G V L E
Sbjct: 2053 S-PKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGE 2111
Query: 2144 AFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI--VNKAMPVFDKPFYTASVNEDIRM 2201
++SN Y +T++A D G+PSLS+S E+ + + +N P+F + Y +NE+
Sbjct: 2112 LDREEVSN--YTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLT 2169
Query: 2202 NTPILSINATSPE----GQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLT 2257
T I+ + A + GQ + Y I++G+ ++F ID TG + V PLD E T Y LT
Sbjct: 2170 GTDIIQVFAADGDEGTNGQ-VRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLT 2228
Query: 2258 IRASDALTGARAEV-TVDLLVNDVNDNPPIFDQPTYNTTLSE-ASLIGTPVLQVVSIDAD 2315
++A+D + R + TV +++ D+ND P+F+ Y+ + E + +LQVV+ D D
Sbjct: 2229 VQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDD 2288
Query: 2316 SENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLS 2375
+N + Y + N + F + S+SG + + LD E + L + + DSG P+L+
Sbjct: 2289 RGSNSKLSYVLFGG--NEDNAFTL-SASGELGVTQSLDRETKERFVLMITATDSGSPALT 2345
Query: 2376 SEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILS 2435
+++ + DVNDN P F Y + + E AP G V V ASDAD+S I+
Sbjct: 2346 GTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADAS--KNAVIRIIG 2403
Query: 2436 GNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG----LFTSTAQVHIRVLGANL 2491
GN + F ++ +G I S + + Y+L V SD +S+ V + V N
Sbjct: 2404 GN--SQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVND 2461
Query: 2492 YSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDS-NG 2550
P F YV + G+ V V TD D G ++ Y+ ++ ++F ID G
Sbjct: 2462 NPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYS-LSGRNSEKFHIDPLRG 2520
Query: 2551 QVITTERLDRENPLEG--DVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYR 2606
++ PL G +V+ V DGG +T TV V V++ D P+ E
Sbjct: 2521 AIMAA------GPLNGASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKAD-FPKVRAKEQT 2573
Query: 2607 ASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNF 2666
+ LVT + G++ R Y AS ++ + +ID G +
Sbjct: 2574 FMFPENQPVSSLVTTI------TGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPL 2627
Query: 2667 NQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
+ K +++A DGG P S + I VL P F + + I E+ +
Sbjct: 2628 DFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKI 2687
Query: 2727 VDTLRI----LPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFK 2782
+ + P+ + + VNG N F I TG I+ + LDRE +
Sbjct: 2688 LTVSAMDKDSGPNGQLDYEIVNG-----NMENSFSINHATGEIRSVRPLDREKVSHYVLT 2742
Query: 2783 VAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMD 2842
+ ++ +V V I +LD NDN P F + + + E P+G +T+V D D
Sbjct: 2743 IKSS-DKGSPSQSTSVKVMINILDENDNAPRF-SQIFSAHVPENSPLGYTVTRVTTSDED 2800
Query: 2843 WGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAF 2902
G N YS+ S P F I+ +TG I + L+ E + V A D G
Sbjct: 2801 IGINAISRYSIMDASLP------FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTV 2854
Query: 2903 SLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSY 2962
S V++ VTDINDNAP F++ Y + E G V + D D N QV Y
Sbjct: 2855 STD----VTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGS-NGQVFY 2909
Query: 2963 HITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLF------------V 3010
I + R + + +++ K+ L + + F N+ F +
Sbjct: 2910 FIKSQSEYFR----INATTGEIFNKQIL-KYQNVTGFSNVNINRHSFIVTSSDRGKPSLI 2964
Query: 3011 TQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSA-KDADIGSNGYIRYSLY 3069
++ V +++ D NDN+P + Y + +++ +++V+A D D G N + Y +
Sbjct: 2965 SETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFIS 3024
Query: 3070 GSGN-SEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGG--RFCQSNIHLILEDVND 3126
+ +F LD ++G + + L + + + A D G Q+ +H+ + + N
Sbjct: 3025 NDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENY 3084
Query: 3127 NPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLAD-SAGGVFSIDSSSG 3185
+ P FS H + + E+ + +++ V A D D +N + YS++ + G+F+I+SS+G
Sbjct: 3085 HTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTG 3144
Query: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
I+ L + LD E + +++ A D + + +VT+ V+D+NDN PVF DY TV
Sbjct: 3145 ILTLAKALDYELCQKHEMTISAID-GGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTV 3203
Query: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCK 3305
E+ GT V+ + AT D GTNA I Y ++S ++ F I+P TG I+ LD+E +
Sbjct: 3204 LENAPSGTTVIHLNATDADSGTNAVIAYTVQS-SDSDLFVIDPNTGVITTQGFLDFETKQ 3262
Query: 3306 RFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIA 3365
++L V+A + + ATVNI L N+ P+F +Y ISE A G V + A
Sbjct: 3263 SYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFA 3322
Query: 3366 EDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGI-- 3423
D D +G++H+ I R F ++ G + V LDRE+ SL V A + G
Sbjct: 3323 SDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIR 3382
Query: 3424 PAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFS 3483
A TVN+ + D ND P+FT Y+ I E P+GT + + D DS + FS
Sbjct: 3383 GADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFS 3441
Query: 3484 FSILSGNEEEEFVLDPHGILRSAVVFQHTESLE-YVLCVQAKDSGKPQQVSHTYIRVRVI 3542
+ I SGNE F ++P + E+L Y L V A DSG P + V +
Sbjct: 3442 YFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLE 3501
Query: 3543 EESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM 3580
+ + + P E + ME+ PG ++ + +TD D+
Sbjct: 3502 DINDNGPMLTVSEGEV--MENKRPGTLVMTLQSTDPDL 3537
Score = 922 bits (2384), Expect = 0.0
Identities = 840/2796 (30%), Positives = 1286/2796 (45%), Gaps = 213/2796 (7%)
Query: 944 KVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEK- 1002
+VLE+ P GT++ ++T G R S + + F I+ ++GA+ + +D E
Sbjct: 50 QVLEEQPPGTLVGTIQTRP-----GFTYRLS---ESHALFAINSSTGALYTTSTIDRESL 101
Query: 1003 -QQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTS 1061
NL V + P V V V D+N+N P FPD ++V + KE+S G
Sbjct: 102 PSDVINLVVLSSAPTYPTE------VRVLVRDLNDN--APVFPDPSIVVTFKEDSSSGRQ 153
Query: 1062 VLQVTARDEDSGRDG--EIQYSIRDGSGLGRFSID---DESGV-----ITAADILDRETM 1111
V+ TA D D G +G Y I G+ GRF +D + SG + + LDRE
Sbjct: 154 VILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVT 213
Query: 1112 GSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQ 1171
Y L V D+G ++V + V+D+NDN P+ Y V E++ SV+Q+
Sbjct: 214 PQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVA 273
Query: 1172 AEDPDSSSNEKLTYRI-TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG 1230
A D D +N + YR+ G P F ++ +TGLI T LD E + ++ L V D G
Sbjct: 274 AADADEGTNADIRYRLQDEGTP---FQMDPETGLI-TVREPLDFEARRQYSLTVQAMDRG 329
Query: 1231 PSPKQSTIWVVVQVLDENDNKP-----QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
++Q+LD NDN P FP + E + G + D D
Sbjct: 330 VPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDE--NAQVGTVVALLTVTDADS 387
Query: 1286 -GPNAEISYSIVDGNDDGKFFID----PKTGMV---SSRKQFTAGSYDILTIKAVDN-GR 1336
N IS I+ GN+ F + P ++ S+ + SY+ LT+ DN G
Sbjct: 388 PAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYN-LTVSVSDNYGA 446
Query: 1337 P------QKSSTARL--HIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQP 1388
P +SS A L + I PP F + Y + E V +S
Sbjct: 447 PPGAAVQARSSVASLVIFVNDINDHPP-----VFSQQVYRVNLSEEAPPGSYVSGISATD 501
Query: 1389 A----NTPLWFDIVGGNFDSAFDAEKGVGTIVIAKP--LDAEQRSIYNMSVEVTD---GT 1439
N L + IV GN F + G + LD E S +++ D
Sbjct: 502 GDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHP 561
Query: 1440 NVAVTQVFIKVLDNNDNGPEFSQP-NYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVH 1498
V+ Q+ + +LD ND P FSQP YDV++ E+ TE+L + ATD D +
Sbjct: 562 KVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFS 621
Query: 1499 SSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVED 1558
R FR+DP +G L T LD E Q + L ++ D P + ++AR+ V++ D
Sbjct: 622 LQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLD 681
Query: 1559 ANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEP 1618
ND+SP F Y A + E+ GS + V+A D D G N + Y+I AG+ + F++
Sbjct: 682 INDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDR-SRFQVNA 740
Query: 1619 VLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQA 1678
G+I+ D + L I TD G+ AIV I+V + ++ P F Y
Sbjct: 741 QSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSF 800
Query: 1679 EVNENVDIGTSVILISAIS---QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTS 1735
V ENV +G V +SA + S + Y + GD G+F IN +G +TT +D E S
Sbjct: 801 VVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQS 860
Query: 1736 SYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSP 1795
YQL + A+ + + VNI + D NDN+P FL + S ++ E +S
Sbjct: 861 FYQLKVVASG-GTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVEN-------WQAGHSI 912
Query: 1796 LVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRD 1855
+A D D N +++Y + + K F ++ G I + LD + + D
Sbjct: 913 FQAKAVDPDEGVNGMVLYSL-KQNPKNLFAINEKNGTISLLGPLDVHA-GSYQIEILASD 970
Query: 1856 SGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVP 1915
G PQL+ S V + + V DVNDN PVF Q +E L V KV A+D DS
Sbjct: 971 MGVPQLS--SSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGAN 1028
Query: 1916 PELTYSLMEGSLDHFLIDSNSGVLTIKN--NNLSKDHYMLIVKVSD---GKFYSTSMVTI 1970
E+ Y++ EG+ G L IK+ + +D Y+L+V SD +T VT+
Sbjct: 1029 GEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTV 1088
Query: 1971 MVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL--NEPLKYSILNPGNKFKI 2028
++++ D+ F + Y+ E + V V+AV N ++YS F++
Sbjct: 1089 ILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFEL 1148
Query: 2029 KSTSGVIQTTGVPFDREE------QELYELVVEASRE-LDHLRVARVVVRVNIEDINDNS 2081
+ SG I T FDRE ++ V A+ + + + V V ++DINDN+
Sbjct: 1149 HAISGEITNTH-QFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNA 1207
Query: 2082 PVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY--VLQDDYGHFEINPNSGNV 2139
P F+ Y A + A T + +V+A D D+G NG + Y + ++ F I+ SG V
Sbjct: 1208 PKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQV 1267
Query: 2140 ILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIV--NKAMPVFDKPFYTASVNE 2197
L + + + Y + I A D G L+++ L I I+ N P F K V E
Sbjct: 1268 TLIGKLDYE-ATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLE 1326
Query: 2198 DIRMNTPILSINAT---SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAY 2254
++R+ + S+ AT S + + Y I + F+I +TG + + LD+E S Y
Sbjct: 1327 NMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLY 1386
Query: 2255 KLTIRASDALTGARAE-VTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSID 2313
KL I A D R+ ++V + V D NDNPP F ++ E IGT V+ V + D
Sbjct: 1387 KLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHD 1446
Query: 2314 ADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPS 2373
D++ N + Y I+Q ++F ID G I T +D E L V++ D P
Sbjct: 1447 PDADINGQLSYTIIQQMPRG-NHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPI 1505
Query: 2374 LSSEVL---VHIYISDVNDNPPVF---NQLIYESYVSELAPRGHFVTCVQASDADSSDFD 2427
+ V I ++D+NDN P+F N L A G +T + A+D D
Sbjct: 1506 ETRRYALKNVTILVTDLNDNVPMFISQNALA----ADPSAVIGSVLTTIMAADPDEGANG 1561
Query: 2428 RLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD-GLFTSTAQVHIRV 2486
+EY I++G D +F++D SG + +++ + +Y+L VS +D G + + +
Sbjct: 1562 EIEYEIING-DTDTFIVDRYSGDLRVAS-ALVPSQLIYNLIVSATDLGPERRKSTTELTI 1619
Query: 2487 LGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDR--- 2543
+ L P F+Q Y+ ++E GT VI + A G+ + Y I++ +++
Sbjct: 1620 ILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAA-SPRGSEAPVEYYIVSVRCEEKTVG 1678
Query: 2544 --FLIDSNGQVITTER-LDRENPLEGD----VSIF-VRALDGGGRTTFCTVRVIVVDEND 2595
F I + +I T LDRE +G V ++ + RT V + + D ND
Sbjct: 1679 RLFTIGRHTGIIQTAAILDRE---QGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDIND 1735
Query: 2596 NAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDP 2655
N P F T +V ++G G + Q+ A+D D+GAN+ +TY++ S A D IDP
Sbjct: 1736 NPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGAD----DSFRIDP 1791
Query: 2656 DNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSF 2715
++G ++ ++ + + S V+A DG ++ S + + I V P F++ YSF
Sbjct: 1792 ESGDLIATRRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHTPKFSRPVYSF 1848
Query: 2716 TIAEDTAIGSTVDTLRILPSQNVWFSTVNGERP----ENNKGGIFVIEQETGTIKLDKRL 2771
I EDT GS V + S VNGE E+++ GIF + TG L + L
Sbjct: 1849 DIPEDTIPGSLVAAILATDDD----SGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLL 1904
Query: 2772 DRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGT 2831
D E + V A D T+ V +LD+NDN P+F +SY T +ME +PVG+
Sbjct: 1905 DYEVQQYYILTVRAE---DGGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGS 1961
Query: 2832 KLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTF 2891
+ D D G N Q+TYS+ S + F +D N G + LK LD E+ +
Sbjct: 1962 TVLVFNVTDADDGINSQLTYSIASGDS----LGQFTVDKN-GVLKVLKALDRESQSFYNL 2016
Query: 2892 SVVASDLGE--AFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTW 2949
V DL + A +STA VS+ + D+NDN P F + E+ P VV
Sbjct: 2017 VVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLT-YIPENTPIDTVVFKAQAT 2075
Query: 2950 DRDTSDVNRQVSYHITGGNPRG-RFALGLVQSEWKVYVKRPLDREEQDIYFLNITATD-- 3006
D D S N + Y + NP G +F++G + E V + LDREE Y L + ATD
Sbjct: 2076 DPD-SGPNSYIEYTLL--NPLGNKFSIGTIDGE--VRLTGELDREEVSNYTLTVVATDKG 2130
Query: 3007 -GLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIR 3065
+ V V V D+NDN+P+ Q Y + E+ + I++V A D D G+NG +R
Sbjct: 2131 QPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVR 2190
Query: 3066 YSLY-GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGG--RFCQSNIHLILE 3122
Y + G+ N EF +D +G + LDRE+ P Y L +ATD G R S + ++L
Sbjct: 2191 YGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLL 2250
Query: 3123 DVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSI 3180
D+ND PVF Y+ V EN T + +V A D D G N K+ Y L + F++
Sbjct: 2251 DINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTL 2310
Query: 3181 DSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRD 3240
S+SG + + Q LDRE + + + + ATD S +L+ T+ + V D+NDN P F +
Sbjct: 2311 -SASGELGVTQSLDRETKERFVLMITATD-SGSPALTGTGTINVIVDDVNDNVPTFASKA 2368
Query: 3241 YLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLD 3300
Y T+PED GT VL V A+ D NA I I GN Q F INP TG I S +LD
Sbjct: 2369 YFTTIPEDAPTGTDVLLVNASDADASKNAVIR--IIGGNSQ--FTINPSTGQIITSALLD 2424
Query: 3301 YELCKRFYLVVEAKDGGTP-ALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDS 3359
E + LVV D G+P LS+ +V + +TDVNDNPP+F Y I L G
Sbjct: 2425 RETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSF 2484
Query: 3360 VILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAV 3419
V + D D PN ++H+S+ +G +F +DP+ G + L+ S + V
Sbjct: 2485 VFAVTVTDADIGPNSELHYSL-SGRNSEKFHIDPLRGAIMAAGPLN--GASEVTFSVHVK 2541
Query: 3420 DSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNG 3479
D G + + TV + + D P T + EN+PV + LV T S G
Sbjct: 2542 DGGSFPKTDSTTVTVRFVNKAD-FPKVRAKEQTFMFPENQPVSS----LVTTITGSSLRG 2596
Query: 3480 PPFSFSILSGNEEEEFVLDP-HGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIR 3538
P S+ I SGN F +D G + + + +YV+ ++A+D G P S+ +
Sbjct: 2597 EPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLD 2656
Query: 3539 VRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM-------YDVLTFALKSE 3591
+ V++ + + P + FI + ++ I + A D+D Y++ +
Sbjct: 2657 ITVLDVNDNAP-IFKEDPFISEILENLSPRKILTVSAMDKDSGPNGQLDYEI----VNGN 2711
Query: 3592 QKSLFKVNSHDGKIIALGGLDSGK---YVLNVSVSD 3624
++ F +N G+I ++ LD K YVL + SD
Sbjct: 2712 MENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSD 2747
Score = 894 bits (2310), Expect = 0.0
Identities = 765/2603 (29%), Positives = 1197/2603 (45%), Gaps = 181/2603 (6%)
Query: 1149 SEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTT 1208
+EP V+E P V IQ + TYR++ + FAIN TG + TT
Sbjct: 43 AEPRQVFQVLEEQPPGTLVGTIQ-------TRPGFTYRLSESHA--LFAINSSTGALYTT 93
Query: 1209 SRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDR 1268
S +DRE + + V P+ V V V D NDN P FP+ I + ++
Sbjct: 94 ST-IDRESLPSDVINLVVLSSAPTYPTE---VRVLVRDLNDNAPVFPDP--SIVVTFKED 147
Query: 1269 KKRGEPIYRAFAFDRDEGPNA--EISYSIVDGNDDGKFFID---PKTGMVSSRKQFTAGS 1323
G + A D D G N SY I+ GN+ G+F +D +G + + G
Sbjct: 148 SSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGG 207
Query: 1324 YDI-------LTIKAVDNGRPQKSSTARLHI--EWIKKPPPSPIPLTFDEPFYNFTVMES 1374
D L ++ D G P++ ++++ + I PP F Y V E
Sbjct: 208 LDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPP-----VFGSSHYQAGVPED 262
Query: 1375 DRVTEIVGVVSVQPANTPLWFDIVGGNFDSA--FDAEKGVGTIVIAKPLDAEQRSIYNMS 1432
V V V+ A+ DI D F + G I + +PLD E R Y+++
Sbjct: 263 AVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEARRQYSLT 322
Query: 1433 VEVTDGTNVAVT---QVFIKVLDNNDNGPE-----FSQPNYDVTISEDVLPDTEILQIEA 1484
V+ D ++T + I++LD NDN P F + ++ E+ T + +
Sbjct: 323 VQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTV 382
Query: 1485 TDRDEKHKLSYTVHSSIDSISMRKFRID----PSTGVLYTAERLDHEAQDKHILNIMVRD 1540
TD D + R F + P+ ++ A LD E + L + V D
Sbjct: 383 TDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSD 442
Query: 1541 Q-------EFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDK 1593
R ++A +++ V D NDH P F+ +Y ++ E A GS V ++A D
Sbjct: 443 NYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDG 502
Query: 1594 DKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEP--DMTTMGQFVLSIKVTDQGSPPM 1651
D G NA L Y+I +GN F I G++T D Q VL+I DQG P
Sbjct: 503 DSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPK 562
Query: 1652 SATAIVRISVTMSDNSHPKFIHKD-YQAEVNENVDIGTSVILISAIS-----QSTLIYEV 1705
+ A + +++ ++ P F + Y V EN GT ++++ A T+ + +
Sbjct: 563 VSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSL 622
Query: 1706 KDGDING-IFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDE 1762
++ + + F ++P SG ++T +LD E + Y L++ AT++ +S A +N+ ++D
Sbjct: 623 QEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDI 682
Query: 1763 NDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKK 1822
NDN+PVF QY + E P S + + + ATD D N + Y I +
Sbjct: 683 NDNSPVFYPVQYFAHIKENEPGGSYITT-------VSATDPDLGTNGTVKYSISAGDRSR 735
Query: 1823 FFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPV 1882
F V++ +G I T LD E + + D G+ L + + V I V D DNPPV
Sbjct: 736 F-QVNAQSGVISTRMALDREEKTAYQLQIVATDGGN--LQSPNQAIVTITVLDTQDNPPV 792
Query: 1883 FTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDH-FLIDSNSGVLTI 1941
F+Q + ++ +G V VSA+ D + ++Y + G F I+ +G LT
Sbjct: 793 FSQVAYSFVVFENVALGYHVGSVSASTMD--LNSNISYLITTGDQKGMFAINQVTGQLTT 850
Query: 1942 KN--NNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNIT 1999
N + + Y L V S G +MV I VK+ D+ HF Q+ S ++ EN
Sbjct: 851 ANVIDREEQSFYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGH 910
Query: 2000 KVAIVNAVG--NRLNEPLKYSIL-NPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEA 2056
+ AV +N + YS+ NP N F I +G I G P D Y++ + A
Sbjct: 911 SIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLG-PLDVHAGS-YQIEILA 968
Query: 2057 SRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPN 2116
S + V++ V + D+NDNSPVF L Y + + ++V A DKD G N
Sbjct: 969 SDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGAN 1028
Query: 2117 GEVTYVLQDDY--GHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVEL 2174
GE+ Y + + F I P+ G + +K + +L + Y + ++A D LS +V +
Sbjct: 1029 GEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRELQD-RYVLMVVASDRAVEPLSATVNV 1086
Query: 2175 PITI--VNKAMPVFDKPFYTASVNEDIRMNTPILSINATS----PEGQGIIYIIIDGDPF 2228
+ + VN P+F+ YT E+ R + + ++A P G+ + Y P
Sbjct: 1087 TVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGE-VRYSFEMVQP- 1144
Query: 2229 KQFNIDFDTGVLKVVSPLDYEV------TSAYKLTIRASDA--LTGARAEVTVDLLVNDV 2280
F + +G + D E T+ + T+ A+D + + TV + + D+
Sbjct: 1145 -DFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDI 1203
Query: 2281 NDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHID 2340
NDN P F + Y T+SE++ T VL+V + D D NN ++HY I++ N F ID
Sbjct: 1204 NDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKG--NEERQFAID 1261
Query: 2341 SSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYE 2400
S+SG + LD+E +L ++++DSG L+S ++I I D NDN P F +
Sbjct: 1262 STSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLF 1321
Query: 2401 SYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQR 2460
V E G V+ V A+D+DS D L YSI N+ +F + +G I L+
Sbjct: 1322 VDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFE 1381
Query: 2461 MEPLYSLNVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIH 2517
+ LY LN++ D +ST V I V N P+F + EN+ GT VI
Sbjct: 1382 TQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVIS 1441
Query: 2518 VRATDGDPGTYGQISYAIINDFAK-DRFLIDS-NGQVITTERLDRENPLEGDVSIFVRAL 2575
V A D D GQ+SY II + + F ID G + T +DRE + V+A
Sbjct: 1442 VTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDRE--FANLFELTVKAN 1499
Query: 2576 DGG-----GRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDG 2630
D R V ++V D NDN P F++ A+ + V G ++T + A DPD+G
Sbjct: 1500 DQAVPIETRRYALKNVTILVTDLNDNVPMFISQNALAADPSAV-IGSVLTTIMAADPDEG 1558
Query: 2631 ANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHS 2690
AN I Y + + + D +D +G + + + V A D G + S
Sbjct: 1559 ANGEIEYEIINGDT----DTFIVDRYSGDLRVASALVP-SQLIYNLIVSATDLGPERRKS 1613
Query: 2691 LIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQN----VWFSTVNGE 2746
+ I + + P FTQ +Y + E IG+ V ++ + V + V+
Sbjct: 1614 TTELTIILQGLDG--PVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVR 1671
Query: 2747 RPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF-KVAATIPLDKVDIVFTVDVDIKVL 2805
E G +F I + TG I+ LDRE + V A +V+I +
Sbjct: 1672 CEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQ 1731
Query: 2806 DLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEA 2865
D+NDN PVF T D + E + G+K+ Q+ A+D D GAN VTY++ S + ++
Sbjct: 1732 DINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGAD-----DS 1786
Query: 2866 FNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFA 2925
F ID +G + + LD E ++ V A D + SS +++ V+D+ND+ P F+
Sbjct: 1787 FRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQ----SSDMRINITVSDVNDHTPKFS 1842
Query: 2926 QEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVY 2985
+ VY ++ E PG +VA + D D S VN +++Y + + G F L + + +
Sbjct: 1843 RPVYSFDIPEDTIPGSLVAAILATD-DDSGVNGEITYIVNEDDEDGIFFLNPITGVFNL- 1900
Query: 2986 VKRPLDREEQDIYFLNITATDGLF-VTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPS 3044
R LD E Q Y L + A DG T V ++ DVNDN P+ +Y+ L E++P
Sbjct: 1901 -TRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPV 1959
Query: 3045 NKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAK 3104
+L + DAD G N + YS+ + F ++G LK L LDRE Y+L+ +
Sbjct: 1960 GSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLKALDRESQSFYNLVVQ 2019
Query: 3105 ATD----GGGRFCQS-NIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
D RF + + +IL DVNDNPP F S T + ENT ++ + QA DPD
Sbjct: 2020 VHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKL-TYIPENTPIDTVVFKAQATDPD 2078
Query: 3160 IGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSL 3219
G N + Y+L + G FSI + G + L LDRE+ S+Y ++V ATD+ SLSS
Sbjct: 2079 SGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQ-PSLSSS 2137
Query: 3220 TTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGN 3279
T V + VLDINDN P+F + Y V + E+T GT ++ VFA D GTN ++ Y I +GN
Sbjct: 2138 TEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGN 2197
Query: 3280 EQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPP 3339
+F+I+ TG I+V++ LD E ++L V+A D G+ + +TV+I L D+ND P
Sbjct: 2198 TNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVP 2257
Query: 3340 KFSQDVYSAVISED-ALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLV 3398
F YS + E+ + +++ ++A D D N ++ + + G+ DN FT+ G +
Sbjct: 2258 VFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLS-ASGEL 2316
Query: 3399 KVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQEN 3458
V + LDRE + L++ A DSG PA++ T T+N+ + DVNDN P F Y I E+
Sbjct: 2317 GVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPED 2376
Query: 3459 KPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH--GILRSAVVFQHTESLE 3516
P GT +L + +D D+ N I+ GN +F ++P I+ SA++ + T+
Sbjct: 2377 APTGTDVLLVNASDADASKNA---VIRIIGGN--SQFTINPSTGQIITSALLDRETKD-N 2430
Query: 3517 YVLCVQAKDSGKPQQV-SHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHA 3575
Y L V D+G P+ + S T + V V + + + P PG + +
Sbjct: 2431 YTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTV 2490
Query: 3576 TDQDM--YDVLTFALKSEQKSLFKVNSHDGKIIALGGLDSGKYV-LNVSVSDGRFQVPID 3632
TD D+ L ++L F ++ G I+A G L+ V +V V DG D
Sbjct: 2491 TDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHVKDGGSFPKTD 2550
Query: 3633 VVVHVEQLVHEMLQNTVTIRFEN 3655
TVT+RF N
Sbjct: 2551 -------------STTVTVRFVN 2560
Score = 764 bits (1972), Expect = 0.0
Identities = 665/2292 (29%), Positives = 1059/2292 (46%), Gaps = 146/2292 (6%)
Query: 1345 LHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDS 1404
L + W+ P + EP F V+E +VG + +P F +
Sbjct: 25 LRVFWLLSLLPGQAWVHGAEPRQVFQVLEEQPPGTLVGTIQTRPG-----FTYRLSESHA 79
Query: 1405 AFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPN 1464
F G + +D E +++ V T+V + V D NDN P F P+
Sbjct: 80 LFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPS 139
Query: 1465 YDVTISEDVLPDTEILQIEATDRD-EKHKLSYTVHSSIDSISMRKFRIDPSTGV------ 1517
VT ED +++ ATD D + + + + I +FR+D +
Sbjct: 140 IVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAF 199
Query: 1518 --LYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASV 1575
L + LD E ++ L + V D+ P RR +V V V+D ND+ P F + Y+A V
Sbjct: 200 LHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGV 259
Query: 1576 FESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMG 1635
E A +GS+VLQV A D D+G NA++ Y ++ + G F+++P G+IT+ + D
Sbjct: 260 PEDAVVGSSVLQVAAADADEGTNADIRYRLQ--DEGTPFQMDPETGLITVREPLDFEARR 317
Query: 1636 QFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHP-----KFIHKDYQAEVNENVDIGTSV 1690
Q+ L+++ D+G P ++ A I + +++ P F A V+EN +GT V
Sbjct: 318 QYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVV 377
Query: 1691 ILI------SAISQSTLIYEVKDGDINGIFTIN----PYSGVITTQKALDYERTSSYQLI 1740
L+ S + + ++ G+ F + P +I ALD ER SY L
Sbjct: 378 ALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLT 437
Query: 1741 IQATNMAGMASNATVN---------IQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSL 1791
+ ++ G A V I + D ND+ PVF Y +LSE AP S V
Sbjct: 438 VSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSG- 496
Query: 1792 DNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRT--IANLDHETIAHFHF 1849
I ATD DS NA L Y IV +F + +G + T LD E +
Sbjct: 497 ------ISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVL 550
Query: 1850 HVHVRDSG-SPQLTAESPVEVNIEVTDVNDNPPVFTQAV-FETILLLPTYVGVEVLKVSA 1907
++ RD G P++ S ++ + + DVND PVF+Q ++ ++ G E+L + A
Sbjct: 551 NISARDQGVHPKV---SYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRA 607
Query: 1908 TDPDSEVPPELTYSLMEGSLDH--FLIDSNSGVL-TIKN-NNLSKDHYMLIVKVSD-GKF 1962
TD D + +SL E D F +D SG L TI + + + Y L+V +D G
Sbjct: 608 TDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSP 667
Query: 1963 YSTSMVTIMVK--EAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL--NEPLKYS 2018
+SM I V + D+ F Y I EN + + V+A L N +KYS
Sbjct: 668 PQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYS 727
Query: 2019 I-LNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDI 2077
I ++F++ + SGVI +T + DREE+ Y+L + A+ + + +V + + D
Sbjct: 728 ISAGDRSRFQVNAQSGVI-STRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDT 786
Query: 2078 NDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSG 2137
DN PVF + Y V + G + V+A D N D G F IN +G
Sbjct: 787 QDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTG 846
Query: 2138 NVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNE 2197
+ + + + Y + ++A GG + T V + + +N P F + + +V E
Sbjct: 847 QLTTANVIDREEQSF-YQLKVVA-SGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVE 904
Query: 2198 DIRMNTPILSINATSPEG--QGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYK 2255
+ + I A P+ G++ + +P F I+ G + ++ PLD S Y+
Sbjct: 905 NWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGS-YQ 963
Query: 2256 LTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDA 2314
+ I ASD + + V + + V+DVNDN P+FDQ +Y TLSE+ + + +V + D
Sbjct: 964 IEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDK 1023
Query: 2315 DSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSL 2374
DS N + Y I + N+ D F I L + + LD EL L V + D L
Sbjct: 1024 DSGANGEIAYTIAEG--NTGDAFGIFPDGQLYIKSE-LDRELQDRYVLMVVASDRAVEPL 1080
Query: 2375 SSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL 2434
S+ V V + + DVNDN P+FN Y Y E G FV V A D D + YS
Sbjct: 1081 SATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSF- 1139
Query: 2435 SGNDRTSFLMDSKSGVITLSNH------RKQRMEPLYSLNVSVSD-GL---FTSTAQVHI 2484
+ F + + SG IT ++ ++R ++S V +D G+ A VH+
Sbjct: 1140 -EMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHV 1198
Query: 2485 RVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRF 2544
+ N +P F + Y A + E+ A T+V+ V A+D D G G I Y+II + +F
Sbjct: 1199 YMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQF 1258
Query: 2545 LIDS-NGQVITTERLDRENPLEGDVSIFVRALDGG--GRTTFCTVRVIVVDENDNAPQFM 2601
IDS +GQV +LD E S+ ++A+D G + CT+ + ++DENDN P F
Sbjct: 1259 AIDSTSGQVTLIGKLDYE--ATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFP 1316
Query: 2602 TVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMV 2661
V ++ G LV+ V A D D G N+ + YS+ + I P+ G +
Sbjct: 1317 KSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSI---TGTNNHGTFSISPNTGSIF 1373
Query: 2662 TKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDT 2721
+ ++ + A D G P + S + V IHV PSF +I E+
Sbjct: 1374 LAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENI 1433
Query: 2722 AIGSTVDTLRILPSQNVWFSTVNGER-----PENNKGGIFVIEQETGTIKLDKRLDRETS 2776
IG++V ++ + +NG+ + +G F I++ GTI + +DRE +
Sbjct: 1434 PIGTSVISVTAHDPD----ADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFA 1489
Query: 2777 PAFHFKVAA---TIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKL 2833
F V A +P++ +V I V DLNDN P+F S +G+ L
Sbjct: 1490 NLFELTVKANDQAVPIETRRYALK-NVTILVTDLNDNVPMF-ISQNALAADPSAVIGSVL 1547
Query: 2834 TQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSV 2893
T + A D D GANG++ Y + + + F +D +G + L + + V
Sbjct: 1548 TTIMAADPDEGANGEIEYEIINGD-----TDTFIVDRYSGDLRVASAL-VPSQLIYNLIV 1601
Query: 2894 VASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPG-EVVAVLSTWDRD 2952
A+DLG S+T L + + PVF Q Y +KE +P G V+++ + R
Sbjct: 1602 SATDLGPERRKSTTELTIILQ---GLDGPVFTQPKYITILKEGEPIGTNVISIEAASPRG 1658
Query: 2953 TSDVNRQVSYHITGGNPRGR-----FALGLVQSEWKVYVKRPLDREE-QDIYFLNITATD 3006
+ V Y+I + F +G + + LDRE+ +Y +++ A +
Sbjct: 1659 S---EAPVEYYIVSVRCEEKTVGRLFTIG--RHTGIIQTAAILDREQGACLYLVDVYAIE 1713
Query: 3007 GLF----VTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNG 3062
+A VE+++ D+NDN PV + E+I I++++A DAD G+N
Sbjct: 1714 KSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANA 1773
Query: 3063 YIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE 3122
+ Y++ + F +DPESG+L LDRER YSL+ +A D G + I++ +
Sbjct: 1774 LVTYTIISGADDSFRIDPESGDLIATRRLDRERRSKYSLLVRA-DDGLQSSDMRINITVS 1832
Query: 3123 DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSID 3181
DVND+ P FS Y+ + E+T +L+ + A D D G+N ++ Y + D G+F ++
Sbjct: 1833 DVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLN 1892
Query: 3182 SSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDY 3241
+G+ L + LD E Q Y ++VRA D G + V +LD+NDNPP+F Y
Sbjct: 1893 PITGVFNLTRLLDYEVQQYYILTVRAED---GGGQFTTIRVYFNILDVNDNPPIFSLNSY 1949
Query: 3242 LVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDY 3301
++ E+ G+ VL T D G N+++TY I SG+ G+F ++ K G + V + LD
Sbjct: 1950 STSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDR 2008
Query: 3302 ELCKRFYLVVEAKD-GGTPA--LSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGD 3358
E + LVV+ D PA ++ A V+I L DVNDNPP F + I E+ +
Sbjct: 2009 ESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLT-YIPENTPIDT 2067
Query: 3359 SVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA 3418
V A D DS PN I ++++N N+F++ + G V++ +LDRE VS Y+L V A
Sbjct: 2068 VVFKAQATDPDSGPNSYIEYTLLN-PLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVA 2126
Query: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
D G P++SS+ V + + D+NDN+P+F A Y I EN GT I+Q+ D D N
Sbjct: 2127 TDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTN 2186
Query: 3479 GPPFSFSILSGNEEEEFVLDP-HGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYI 3537
G + I++GN +EF +D G + A ++ Y L VQA D G + + +
Sbjct: 2187 G-QVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTV 2245
Query: 3538 RVRVIEESTHKP 3549
+ +++ + P
Sbjct: 2246 SIVLLDINDFVP 2257
Score = 117 bits (294), Expect = 2e-25
Identities = 52/118 (44%), Positives = 66/118 (55%), Gaps = 1/118 (0%)
Query: 4018 CVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDP 4077
C + D C SPC GG+C L GG+ C+C FTGR CE +I C +PC+NG C
Sbjct: 3859 CEIDIDECLPSPCHSGGTCHNLV-GGFSCSCPDGFTGRACERDINECLQSPCKNGAICQN 3917
Query: 4078 IGNTFICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCGL 4135
+F C CK G TG CE +N CE C NGGSC + S+ C+C G G++C L
Sbjct: 3918 FPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCEL 3975
Score = 109 bits (273), Expect = 5e-23
Identities = 51/132 (38%), Positives = 64/132 (48%), Gaps = 21/132 (15%)
Query: 4023 DACKRSPCQHGGSC---------------------TGLPSGGYQCTCLSQFTGRNCESEI 4061
D+C PCQ+GGSC P + C CL + G CE +I
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDI 3863
Query: 4062 TACFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFL 4121
C P+PC +GG+C + F C+C G TG CE DINEC + C+NG C N GSF
Sbjct: 3864 DECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGSFN 3923
Query: 4122 CNCTPGYVGQYC 4133
C C GY G+ C
Sbjct: 3924 CVCKTGYTGKMC 3935
Score = 99.8 bits (247), Expect = 6e-20
Identities = 87/348 (25%), Positives = 142/348 (40%), Gaps = 53/348 (15%)
Query: 3792 CPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGE-----CSGHTSLSFAGNSYI 3846
CP C PC C+ Y + ++ C C G G+ + T+LS G +
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQ---CHCKEGLTGKYCEKSVTPDTALSLEGKGRL 4215
Query: 3847 KYRLSENSKEEDF----------------KLALRLRTLQSNGIIMYTR-ANPCIILKIVD 3889
Y +S+N K E L ++ RT NG++++ + ++ +KI +
Sbjct: 4216 DYHMSQNEKREYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQESSNYTTVKIKN 4275
Query: 3890 GKLWFQLDCG-SGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQ 3948
GK++F D G +G I V DG WH+ + N T LS+D +Y +
Sbjct: 4276 GKVYFTSDAGIAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDR---------IYNR 4326
Query: 3949 TLSTESSIYFGALVQADNIRSLTDTRVTQ--VLSGFQGCLDSVILNNNELPLQNKRSSFA 4006
+ + + G V ++ + + + +GF GC+ S+ LP K S +
Sbjct: 4327 DIIHPTQDFGGLDVLTISLGGIPPNQAHRDAQTAGFDGCIASMWYGGESLPFSGKHSLAS 4386
Query: 4007 EVVGLTELKLGCVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFP 4066
+K+GC P+ C +PC C++Q+ C C
Sbjct: 4387 ISKTDPSVKIGC-RGPNICASNPCWG------------DLLCINQWYAYRCVPP-GDCAS 4432
Query: 4067 NPCRNGGSCDP-IGNTFICNCKAGLTGVTCEEDINECEREECENGGSC 4113
+PC+NGGSC+P + + F C+C TG TCE + C C G C
Sbjct: 4433 HPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEM-VVACLGVLCPQGKVC 4479
Score = 80.9 bits (198), Expect = 3e-14
Identities = 87/307 (28%), Positives = 130/307 (42%), Gaps = 37/307 (12%)
Query: 3775 VCPRFYRNVRCTCNGG----LCPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLG 3830
+C F + C C G +C S + C PC C S S + C CP G G
Sbjct: 3914 ICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDS---YYCHCPFGVFG 3970
Query: 3831 ECSGHTSLSFAGNSYIKY-RLSENSKEEDFKLALRLRTLQSNGIIMYTRANPC------I 3883
+ S F SY+++ L N+ K A T++S+ +++Y N +
Sbjct: 3971 KHCELNSYGFEELSYMEFPSLDPNNNYIYVKFA----TIKSHALLLYNYDNQTGDRAEFL 4026
Query: 3884 ILKIVDGKLWFQLDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRA 3943
L+I + +L F + GSG L + + V+DG +H+V SL++D +
Sbjct: 4027 ALEIAEERLRFSYNLGSGTYKL-TTMKKVSDGHFHTVIARRAGMAASLTVDSC--SENQE 4083
Query: 3944 PLYFQTLSTESSIYFGALVQADN-----IRSLTDT--RVTQVLS-GFQGCLDSVILNNNE 3995
P Y + S + VQ + IRSL R V S F GC+ +N
Sbjct: 4084 PGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGHVESHDFVGCIMEFAVNGR- 4142
Query: 3996 LPLQNKRSSFAEVVGLTELKLGCVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGR 4055
PL+ ++ A+ G+ + C AC RSPCQHGG+C S QC C TG+
Sbjct: 4143 -PLEPSQALAAQ--GILDQ---CPRLEGACTRSPCQHGGTCMDYWS-WQQCHCKEGLTGK 4195
Query: 4056 NCESEIT 4062
CE +T
Sbjct: 4196 YCEKSVT 4202
Score = 37.4 bits (85), Expect = 0.34
Identities = 12/32 (37%), Positives = 20/32 (62%)
Query: 4102 CEREECENGGSCVNVFGSFLCNCTPGYVGQYC 4133
C R C++GG+C++ + C+C G G+YC
Sbjct: 4166 CTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYC 4197
Score = 35.4 bits (80), Expect = 1.3
Identities = 20/66 (30%), Positives = 25/66 (37%), Gaps = 23/66 (34%)
Query: 4091 TGVTCEE-DINECEREECENGGSCVNVFG----------------------SFLCNCTPG 4127
+GV E D + C C+NGGSC+ FLC C PG
Sbjct: 3794 SGVKVESVDHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPG 3853
Query: 4128 YVGQYC 4133
Y G +C
Sbjct: 3854 YAGSWC 3859
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 895 bits (2314), Expect = 0.0
Identities = 851/2984 (28%), Positives = 1376/2984 (46%), Gaps = 248/2984 (8%)
Query: 718 INRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNID 777
+NR + + F + + + ED PVG+++ ++ A D D N ++F +S F ++
Sbjct: 25 VNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVE 81
Query: 778 METGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYS 837
+TG + + P+DRE + + ++ D Q R + I V D NDN+P F YS
Sbjct: 82 PDTGVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQPYS 138
Query: 838 VNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESK 897
V I E++ +GT I V A D DLG+ G V YS +Q FAI+S+ GIV V +LD E+
Sbjct: 139 VRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETT 198
Query: 898 ANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAW 957
Y L + A D+ + + L ++ L + + DV D P FI YS + E P GT +
Sbjct: 199 QAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRI 257
Query: 958 LETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQF---YNLTVRA- 1012
+ D D G + Y++V+ + N F +D SG + L+ LD E + + LTV+
Sbjct: 258 ITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
Query: 1013 --KDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSV---LQVTA 1067
D P + + + V+D+N+N P F ++ E +++G ++ +QV
Sbjct: 318 ELNDDRTPSDATVTTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQVVD 375
Query: 1068 RDEDSGRDGEIQ-YSIRDGSG---LGRFSIDDESGV-ITAADILDRETMGSYWLTVYATD 1122
+DE+ G + + Y + + S + S+ ++ + I A LD ET+ Y ++A +
Sbjct: 376 KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE 435
Query: 1123 RGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEK 1182
V +V I + + NDN P+ S+P+Y + EN SV+ + A D D+ + +
Sbjct: 436 -SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGE 494
Query: 1183 LTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVV 1242
++Y S +P F+++ TGLI +R LD E L + DGG +++T V +
Sbjct: 495 VSY-FFSDDPDR-FSLDKDTGLIMLIAR-LDYELIQRFTLTIIARDGG--GEETTGRVRI 549
Query: 1243 QVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDG 1302
VLD NDN P F + Y L R+ + + R A D D PN +I+YSIV + G
Sbjct: 550 NVLDVNDNVPTFQKDAYVGAL--RENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFG 607
Query: 1303 KFF---IDPKTGMVSSRK----QFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPP 1355
+F + G++S + + + LT+ A+D G P +ST + IE +
Sbjct: 608 SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDE--- 664
Query: 1356 SPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFD----IVGGNFDSAFDAEKG 1411
+ P TF +P Y +V+E+ V ++ + + I + F
Sbjct: 665 NDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINAR 724
Query: 1412 VGTIVIAKPLDAEQRSIYNMSVEVTDG-----TNVAVTQVFIKVLDNNDNGPEFSQPNYD 1466
G I LD E +S Y + V DG + V I +LD NDN P + Y
Sbjct: 725 SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 784
Query: 1467 VTISEDVLPDTEILQIEATDRD--EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAE-R 1523
+ + E PD+++ + A D D E L Y++ + + ++ +TG + T
Sbjct: 785 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQP-----PNKFYSLNSTTGKIRTTHAM 839
Query: 1524 LDHEAQDKHILNIM------VRDQEFPYRR--NLARVIVNVEDANDHSPYFTNPLYEASV 1575
LD E D H +M V D P + + A V VN+ D ND+ P F N + A V
Sbjct: 840 LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEV 899
Query: 1576 FESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMG 1635
E G ++ QV A+D D+G N + Y + G F I G++ E D +
Sbjct: 900 LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA 959
Query: 1636 QFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISA 1695
++ L + +D G+P S+T+ + I V ++ P F Y V+E+V V+ ++
Sbjct: 960 EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019
Query: 1696 IS-----QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGM- 1749
+ L Y + G+++G F++ V+ T LD E T++Y LI++A + +
Sbjct: 1020 TDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVG 1079
Query: 1750 ---ASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSN 1806
ATV + ++D NDN P+FL S Y S+ E P +S L ++ATDAD
Sbjct: 1080 KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEG-------HSILQLKATDADEG 1132
Query: 1807 RNALLVYQIVESTAKKFFTVDSSTGAI-RTIANLDHETIAHFHFHVHVRDSGSPQL-TAE 1864
+ Y+I+ F + S G + R LD E + HV + ++ + L
Sbjct: 1133 EFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSS---HVLIVEAYNHDLGPMR 1189
Query: 1865 SPVEVNIEVTDVNDNPPVFTQAVFETILLLPTY-VGVEVLKVSATDPDSEVPPELTYSLM 1923
S V V + V D+ND PVFTQ + + L T +G V+ V ATD DS + Y ++
Sbjct: 1190 SSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL 1249
Query: 1924 EGSLDHFLIDSNSGVLTIKN--NNLSKDHYMLIVKVSD-----GKFYSTSMVTIMVKEAM 1976
G+ F ID ++G++ N + +K YM+ V +D + + + +T++ +
Sbjct: 1250 SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLL--NEL 1307
Query: 1977 DSGLHFTQSFYSTSISEN---NTNITKVAI-----VNAVGNRLNEPLKYSILNPGNKFKI 2028
D + F+ + Y +I EN T I +V +N + R N Y+ FKI
Sbjct: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFN---AYTSTQAKALFKI 1364
Query: 2029 KSTSGVIQTTGVPFDREEQELYELVV---EASRELDHLRVARVVVRVNIEDINDNSPVFV 2085
+ +GVI G+ DRE+ + Y L V + ++D + V V + + D NDNSP F
Sbjct: 1365 DAITGVITVQGL-VDREKGDFYTLTVVADDGGPKVD----STVKVYITVLDENDNSPRFD 1419
Query: 2086 GLPYYA-AVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDD--YGHFEI---NPNSGNV 2139
A ++ D G + V A D D G NG+V + L G FEI N + G V
Sbjct: 1420 FTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEV 1479
Query: 2140 ILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI--VNKAMPVFDKPF-YTASVN 2196
+ + + + Y + ++A D G P L +TI +N PV + PF Y SVN
Sbjct: 1480 FVARPLDREELD-HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVN 1538
Query: 2197 EDIRMNTPILSINATSPE---GQGIIYIIIDGDPFKQFNIDFDTGVLKV-VSPLDYEVTS 2252
E++ T ++ + AT + + Y I +G+ F +D +G + +P D E S
Sbjct: 1539 ENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQS 1598
Query: 2253 AYKLTIRASDALTGARAEVT-VDLLVNDVNDNPPIFDQPTYNTTLSEA-SLIGTPVLQVV 2310
Y L D T + T V + + D NDN P+F QP Y L E + T ++ +
Sbjct: 1599 FYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQ 1658
Query: 2311 SIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQ-HCTLKVRSIDS 2369
++D D N V Y IV N + F ID G+I A+ LD+E+ TL V + D
Sbjct: 1659 ALDLDEGPNGTVTYAIVAG--NIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQ 1716
Query: 2370 GFPSLS----SEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSD 2425
P LS S V + ++D+NDN P F + + G V A D DS
Sbjct: 1717 -CPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGP 1775
Query: 2426 FDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPL--YSLNVSVSD-GL--FTSTA 2480
++EYSI+ G+ F++ GV+ + + E + Y+L + D G+ +ST
Sbjct: 1776 NGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTM 1835
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFA 2540
V IRVL N P + EN + V HV A+D D G ++++ I
Sbjct: 1836 LVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNR 1895
Query: 2541 KDRFLIDSNGQVITTER-LDRENPLEGDVSIFVRALDGG---GRTTFCTVRVIVVDENDN 2596
+ F I++ ++T R LDRE E ++I V+ R + + + + DENDN
Sbjct: 1896 ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
Query: 2597 APQFMTVEYRASVRADVGRGHLVT----QVQAIDPDDGANSRITYSLYSEASVSVADLLE 2652
P F Y+A V + G +T + A+D D + +TY L S L +
Sbjct: 1956 HPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS----GLFD 2011
Query: 2653 IDPDNGWMVTKGNF----NQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSF 2708
I+ G + + +L + A D G+ +S + I +L P+F
Sbjct: 2012 INSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL--LNSTAHLLITILDDNDNRPTF 2069
Query: 2709 TQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGE---RPENNKGGIFVIEQETGTI 2765
+ + + + E+ G +V L++ + S +NGE R E F+I TG I
Sbjct: 2070 SPATLTVHLLENCPPGFSV--LQVTATDE--DSGLNGELVYRIEAGAQDRFLIHLVTGVI 2125
Query: 2766 KL-DKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIM 2824
++ + +DRE ++ V AT V + T V I + D+ND++P F ++
Sbjct: 2126 RVGNATIDREEQESYRLTVVAT-DRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVL 2184
Query: 2825 EGMPVGTKLTQVRAIDMDWGANGQVTYSL-------HSDSQPEKVMEAFNIDSNTGWIST 2877
E GT + + AID D N ++ Y + +D +AF ++ NTG +
Sbjct: 2185 ESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV 2242
Query: 2878 LKDLDHETDPTF--TFSVV--ASDLGEAFSLSSTALVSVRVTDINDNAPVFAQ---EVYR 2930
++ E T+ T SV+ ASDL E A ++V V D+NDN P F Y
Sbjct: 2243 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYM 2302
Query: 2931 GNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPL 2990
+ E PG + ++ D D +N V+Y + P G L S KV R +
Sbjct: 2303 ERILEGATPGTTLIAVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLE-DSSAGKVIANRTV 2360
Query: 2991 DREEQDIYFLNIT--ATDGLFVTQAM---VEVSVSDVNDNSPVCDQVAYTALLPEDIPSN 3045
D EE +++LN T A+D +A V + + D+NDN+P+ DQ +Y + ED+P
Sbjct: 2361 DYEE--VHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVG 2418
Query: 3046 KIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKA 3105
IIL V+A DAD G+ I YSL G G S+F ++P +G++ L+ LDRE+ Y L A A
Sbjct: 2419 TIILTVTATDADSGNFALIEYSL-GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALA 2477
Query: 3106 TDGGGRFC----QSNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
D G ++++ ++++ DVND P FS ++T VYEN + + A D D
Sbjct: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD 2537
Query: 3160 IGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSL 3219
G N ++ YSL F +D SG++ ++PL + ++++V ATD L
Sbjct: 2538 EGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGE-PPLWGT 2594
Query: 3220 TTVTITVLDINDNPPVFER--RDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITY--LI 3275
T + + V+D+NDN PVF R ++ + E+ + V V+AT KD G N + Y L
Sbjct: 2595 TMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLK 2654
Query: 3276 RSGNEQGK-FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPA-LSAVATVNINLTD 3333
+GN + F I+P +G I ++ LD E + L++ A D G P + + + L D
Sbjct: 2655 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALED 2714
Query: 3334 VNDN------PPKFSQDVYSAVISEDALVGDSV-ILLIAEDVDSQPNGQIHFSIVNGDRD 3386
++DN PPK S + E + G V + A D D PN +++ I G+ +
Sbjct: 2715 IDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEE 2774
Query: 3387 NEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVD--SGIPAMSSTAT-----------VN 3433
F + P G + V + LDRER + +S +V+A S P + T V
Sbjct: 2775 KNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVR 2833
Query: 3434 IDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILS----- 3488
+ + D+ND P FT A YTA + + VG+ ++Q++ D D +N F +SIL+
Sbjct: 2834 VVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF-YSILAIHYFR 2892
Query: 3489 --GNEEEE----FVL-DPHGILRSAVVFQHTESLEYVLCVQAKD 3525
N+ E+ F + GILR+ +F +V+ + A+D
Sbjct: 2893 ALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARD 2936
Score = 879 bits (2270), Expect = 0.0
Identities = 847/2948 (28%), Positives = 1321/2948 (44%), Gaps = 254/2948 (8%)
Query: 586 VISYDFPVGGHITAVSAIDIDELELVKYKIISGNELG-FFYLNPDSGVLQLKKSLTNSGI 644
+IS D PVG +T + A D+D LV +SG E FF + PD+GV+ L++ L
Sbjct: 41 LISEDTPVGSSVTQLLAQDMDNDPLVFG--VSGEEASRFFAVEPDTGVVWLRQPLDRE-- 96
Query: 645 KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANG 704
F + + +D + + TR
Sbjct: 97 TKSEFTVEFSVSDHQGVI-----------------------TR----------------- 116
Query: 705 KLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFT 764
K+N++ G +N P F P V + E+ PVG I + A D D G G VL++
Sbjct: 117 KVNIQVG-----DVNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYS 170
Query: 765 ISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQK-SSWRLLTINVED 823
F ID G + V+ +D E T Y L + D + S+ L I + D
Sbjct: 171 FQP--PSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITD 228
Query: 824 ANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINS 881
D P+FI YS NI E S GT + + A D+D G + Y++++ FA++
Sbjct: 229 VQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDY 288
Query: 882 STGIVYVADQLDRES---KANYSLKIEARDKAESGQQLFSVV--TLKVFLDDVNDCSPAF 936
+G++ + LDRE+ + L ++ + + + V T + + D+ND +P F
Sbjct: 289 ISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 348
Query: 937 IPSSYSVKVLEDLPVGTVI-AWLETHDPD--LGLGGQVRYSLVNDYNGRFEID------K 987
S YSV + E VG + +++ D D LGL LV + + F I K
Sbjct: 349 NSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGK 408
Query: 988 ASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFA 1047
A IR++ LDYE Y+ + A + V + +V++ +NEN + P F
Sbjct: 409 ADIRIRVAIPLDYETVDRYDFDLFANES----VPDHVGYAKVKITLINENDNRPIFSQPL 464
Query: 1048 VVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILD 1107
S+ EN +GTSVL V A D D+G GE+ Y D RFS+D ++G+I LD
Sbjct: 465 YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP--DRFSLDKDTGLIMLIARLD 522
Query: 1108 RETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV 1167
E + + LT+ A D G +T V I V DVNDN P + Y + EN P +
Sbjct: 523 YELIQRFTLTIIARDGGGEE--TTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQL 580
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNP-QNFFAINIKTGL-ITTTSRKLDREQQAEHFLEVT 1225
++++A D DS N ++TY I S + ++F I++ G + + SR LD EQ + + +T
Sbjct: 581 VRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 640
Query: 1226 V--TDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDR 1283
V D G P ST+ V ++V DENDN P F + Y + + E A DR
Sbjct: 641 VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR 700
Query: 1284 DEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK---QFTAGSYDILTIKAVDN--GRPQ 1338
E ++G+ +F I+ ++G +++ + T Y IL ++AVD G Q
Sbjct: 701 SREYGQESIIYSLEGST--QFRINARSGEITTTSLLDRETKSEY-ILIVRAVDGGVGHNQ 757
Query: 1339 KSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQP---ANTPLWF 1395
K+ A ++I + P D P+Y V + +++ VV+V P N L +
Sbjct: 758 KTGIATVNITLLDINDNH--PTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
Query: 1396 DIVGGNFDSAFDAEKGVGTIVIA-----KPLDAEQRSIYNMSVEVTDGTN-----VAVTQ 1445
I N + ++ G A P E + + V VTD +
Sbjct: 816 SIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSAT 875
Query: 1446 VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE--KHKLSYTVHSSIDS 1503
VF+ +LD NDN P F + + E + I Q+ A D DE +SY + +
Sbjct: 876 VFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPR 935
Query: 1504 ISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHS 1563
+ F I+ S+GV+ T LD E ++ L ++ D P + + + + ++V D ND +
Sbjct: 936 MD---FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDET 992
Query: 1564 PYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGII 1623
P F +Y SV E V+ + D D G NAEL Y I GN F + ++
Sbjct: 993 PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVV 1052
Query: 1624 TICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSD--NSHPKFIHKDYQAEVN 1681
D T ++L ++ D G T + VT+ D ++ P F+ Y+A V
Sbjct: 1053 RTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVP 1112
Query: 1682 ENVDIGTSVILISAISQ-----STLIYEVKDGDINGIFTINPYSGVITT-QKALDYERTS 1735
E++ G S++ + A + Y + G+ F I+ +G++ + LD ER S
Sbjct: 1113 EDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNS 1172
Query: 1736 SYQLIIQATN--MAGMASNATVNIQIVDENDNAPVFLFSQYSG-SLSEAAPINSIVRSLD 1792
S+ LI++A N + M S+ V + + D ND APVF QYS L E A I +
Sbjct: 1173 SHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGT------ 1226
Query: 1793 NSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVH 1852
S +V++ATD DS L+ Y+I+ S A+ F +D STG I T+ LD+ET + +V
Sbjct: 1227 -SVIVVQATDRDSGDGGLVNYRIL-SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVS 1284
Query: 1853 VRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDS 1912
D P + V I + + D F+ A +E +L +G E+++V A D+
Sbjct: 1285 ATDQAPP--FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
Query: 1913 EVPPELTYSLMEGSLDH----FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDG--KFYS 1964
++TY + F ID+ +GV+T++ + D Y L V DG K S
Sbjct: 1343 --LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDS 1400
Query: 1965 TSMVTIMVKEAMDSGLHFT-QSFYSTSISENNTNITKVAIVNA----VGNRLNEPLKYSI 2019
T V I V + D+ F S + SI E+ +VA V A G+ +
Sbjct: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
Query: 2020 LNPGNKFKIKSTSGVIQTTGV--PFDREEQELYELVVEASRELDHLRVARVVVRVNIEDI 2077
N F+I +T+ I V P DREE + Y L V AS R +++V I DI
Sbjct: 1461 GNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDI 1520
Query: 2078 NDNSPVFVG-LPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGH--FEINP 2134
NDN PV Y +V + GT + QV A D+D G N ++Y + + F ++
Sbjct: 1521 NDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDR 1580
Query: 2135 NSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIV--NKAMPVFDKPFYT 2192
SG + + A Y + +D G P+LS + + +TIV N P+F +P Y
Sbjct: 1581 ISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE 1640
Query: 2193 ASVNE-DIRMNTPILSINA----TSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLD 2247
++E +NT +++I A P G + Y I+ G+ F ID GV+ LD
Sbjct: 1641 VLLDEGPDTLNTSLITIQALDLDEGPNGT-VTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699
Query: 2248 YEVT-SAYKLTIRASD--ALTGARAEVTVDLL--VNDVNDNPPIFDQPTYNTTLSEASLI 2302
YE++ Y L + A+D + R T +L VND+NDN P F +
Sbjct: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP 1759
Query: 2303 GTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTAR--MLDHELVQHC 2360
G V ++ D DS N V Y I+ + F I G++ + LD E +
Sbjct: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDG--DPLGEFVISPVEGVLRVRKDVELDRETIAFY 1817
Query: 2361 TLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASD 2420
L + + D G P LSS +LV I + D+NDN PV L +SE +P FV V ASD
Sbjct: 1818 NLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASD 1877
Query: 2421 ADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTA 2480
ADS RL ++I +GN +F +++ +G++T++ + P Y L +SV D
Sbjct: 1878 ADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRI 1937
Query: 2481 Q------VHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI----HVRATDGDPGTYGQ 2530
+ I + N P F++STY AEV EN AGT + + A D D Y
Sbjct: 1938 ARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV 1997
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTER---LDRENPLEGDVSIFVRALDGGGRTTFCTVR 2587
++Y ++ F I+S+ V+T +DRE + + + A D G + +
Sbjct: 1998 VTYQLLG-AQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLL 2056
Query: 2588 VIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSV 2647
+ ++D+NDN P F + + G V QV A D D G N + Y + + A
Sbjct: 2057 ITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ--- 2113
Query: 2648 ADLLEIDPDNGWM-VTKGNFNQLKNTVLSFFVKAVD-GGIPVKHSLIPVYIHVLPPETFL 2705
D I G + V ++ + V A D G +P+ + I V I +
Sbjct: 2114 -DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAI-VTILIDDINDSR 2171
Query: 2706 PSFTQSQYSFTIAEDTAIGSTVDTLRILP---SQNVWFSTV------NGERPENNKGGIF 2756
P F + ++ E G+ + + + + + + V + +R N+ F
Sbjct: 2172 PEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAF 2231
Query: 2757 VIEQETGTIKLDKRLDRETSPAFHFKV-----AATIPLDKVDIVFTVDVDIKVLDLNDNK 2811
+ TG++ + ++RE + + A+ +P V + + + VLD+NDN
Sbjct: 2232 AVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP-NAKLTVNVLDVNDNT 2290
Query: 2812 PVFE---TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNI 2868
P F+ + Y I+EG GT L V A+D D G NG VTY+L P V
Sbjct: 2291 PQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE--- 2347
Query: 2869 DSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEV 2928
DS+ G + + +D+E F+V ASD G ++ V + + DINDN P+F Q
Sbjct: 2348 DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP-PRAAEIPVYLEIVDINDNNPIFDQPS 2406
Query: 2929 YRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKR 2988
Y+ V E P G ++ ++ D D+ + + Y + G+ +FA+ + +YV
Sbjct: 2407 YQEAVFEDVPVGTIILTVTATDADSGNF-ALIEYSL--GDGESKFAINPTTGD--IYVLS 2461
Query: 2989 PLDREEQDIYFLNITATD-------GLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPED 3041
LDRE++D Y L A D V + V DVND P + ++ + E+
Sbjct: 2462 SLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYEN 2521
Query: 3042 IPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSL 3101
P+ ++ + A D D G NG + YSL G G F +D +SG + T L + +SL
Sbjct: 2522 EPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
Query: 3102 MAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVY--ENTATKALLTRVQAVD 3157
ATDGG L++E DVNDN PVF T ++ E ++ + V A D
Sbjct: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
Query: 3158 PDIGINRKVVYSLADSAGG----VFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPG 3213
D G+N V YS +AG F ID SG+I Q LDRE Q+ Y++ + A+D
Sbjct: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 2699
Query: 3214 QSLSSLTTVTITVLDINDNPPVFER------RDYLVTVPEDTSPGTQVLAVF-ATSKDIG 3266
++ + + + DI+DN P+F R + L+TVPE + GT V V A D G
Sbjct: 2700 VPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEG 2759
Query: 3267 TNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKD--------GGT 3318
NA + Y I +GNE+ F + P G + V LD E F +V+A G +
Sbjct: 2760 PNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPS 2818
Query: 3319 PALSAVA-----TVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPN 3373
P L VA V + L D+ND PP+F++ Y+A ++ DA VG +I ++A D D N
Sbjct: 2819 PTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNN 2878
Query: 3374 GQIHFSIV 3381
+ +SI+
Sbjct: 2879 SLVFYSIL 2886
Score = 861 bits (2224), Expect = 0.0
Identities = 829/2985 (27%), Positives = 1344/2985 (45%), Gaps = 286/2985 (9%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
L+RE + + V+ SV KVNIQV D+ND P F YSV I E+TP+ T
Sbjct: 93 LDRETKSEFT--VEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
Query: 177 VAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDR 236
+ V ATD D+G+ G Y F+ F++ G++++ L+Y+ Y L + A D+
Sbjct: 151 IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
Query: 237 GMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFS---LEKEP---TYAVVTVDDL 290
+S+ A L + I + + P + ++P+S E P T ++T D
Sbjct: 211 DK----TRPLSTLANLAIIITDVQDMDP---IFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
Query: 291 DDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDK 350
D G I +IV+G+ F L L + +R+ + +G+ LT++ +
Sbjct: 264 DKGRPRGI-GYTIVSGNTNSIFALDYISGVLTLNGLLDREN---PLYSHGFILTVKGTEL 319
Query: 351 GSPQKCSALKAVYIGN----PTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID 406
+ S N D P F Y V+I+E + G + L + +D
Sbjct: 320 NDDRTPSDATVTTTFNILVIDINDNAP-EFNSSEYSVAITELAQVGFA---LPLFIQVVD 375
Query: 407 VEYKLS---------PGEDAVYFKINPRSG------LIVTARPLNTVKKEVYKLEVTNKE 451
+ L G ++ +F I+P S I A PL+ + Y ++ E
Sbjct: 376 KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE 435
Query: 452 GDLK----AQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYI 507
A+V I++ + ND+ P F QPLY+ + E+V VGTSVLTV A+D D G G +
Sbjct: 436 SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEV 495
Query: 508 TYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIR 567
+Y + + F +++ TG+I LD+E + + + A D G E+ V I
Sbjct: 496 SYFFSD-DPDRFSLDKDTGLIMLIARLDYELI-QRFTLTIIARDGGG---EETTGRVRIN 550
Query: 568 IGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELGFFY 625
+ +VNDN P F+K A G + + P + + A D D + Y I+S + G ++
Sbjct: 551 VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
Query: 626 ---LNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFS 682
L GV+ + + L I NG L + A D N P++ + V
Sbjct: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN--PPLNSTVPVT---------- 658
Query: 683 CRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVG 742
++ + N P F K V+V E++ G
Sbjct: 659 ------------------------------IEVFDENDNPPTFSKP-AYFVSVVENIMAG 687
Query: 743 ANILKIKAYDADSG--FNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLN 800
A +L + A D D + + + +G+T F I+ +G++ +DRE Y+L
Sbjct: 688 ATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILI 745
Query: 801 ITIYD--LGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDK 858
+ D +G+ QK+ + I + D NDN P + Y +N++E + +++ V A D
Sbjct: 746 VRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805
Query: 859 DLGSNGEVTYSVLTDTQQFAINSSTGIVYVAD-QLDRESKANY------SLKIEARDKAE 911
DLG NG + YS+ + +++NS+TG + LDRE+ + + + D
Sbjct: 806 DLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGR 865
Query: 912 SGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQV 971
+ S T+ V L D+ND P F + +VLE +P G I + D D GL G V
Sbjct: 866 PPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 925
Query: 972 RYSL-VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
Y + V F I+ +SG + + ELD E+ Y L V A D G P SS S + +
Sbjct: 926 SYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTK-SSTSTLTIH 984
Query: 1031 VVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGR 1090
V+DVN+ T +FP V SV E+ V+ + D D G + E+ Y I G+ G+
Sbjct: 985 VLDVNDETPT-FFPAVYNV-SVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGK 1042
Query: 1091 FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL--YSTIEVYIEVEDVNDNAPLT 1148
FS+ V+ LDRET +Y L + A D G V T V++ V DVNDN P+
Sbjct: 1043 FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF 1102
Query: 1149 SEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTT 1208
+ Y V E+ P+ S++Q++A D D ++ YRI GN N F I++ GL+
Sbjct: 1103 LQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRG 1162
Query: 1209 SRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDR 1268
R LDRE+ + H L V + P +S++ V+V V D ND P F ++ Y +L R+
Sbjct: 1163 PRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYS-RLGLRET 1221
Query: 1269 KKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYD 1325
G + A DRD G ++Y I+ G +GKF ID TG++ + T SY
Sbjct: 1222 AGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSY- 1279
Query: 1326 ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV-TEIVGVV 1384
++ + A D P ++I + + + + F Y ++E+ + TEIV V
Sbjct: 1280 MMNVSATDQAPPFNQGFCSVYITLLNELDEA---VQFSNASYEAAILENLALGTEIVRVQ 1336
Query: 1385 SVQPAN----TPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
+ N T + + F + G I + +D E+ Y ++V DG
Sbjct: 1337 AYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGP 1396
Query: 1441 V--AVTQVFIKVLDNNDNGPEFS-QPNYDVTISEDVLPDTEILQIEATDRD--EKHKLSY 1495
+ +V+I VLD NDN P F + V+I ED + ++A D D ++ +
Sbjct: 1397 KVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVF 1456
Query: 1496 TVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVN 1555
++ S + + + S G ++ A LD E D +IL ++ D+ P R+ + V
Sbjct: 1457 SLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVT 1516
Query: 1556 VEDANDHSPYFTNPL-YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMF 1614
+ D ND+ P +P Y SV E+ G+AV+QV A D+D G N+ L Y I GN F
Sbjct: 1517 ILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAF 1576
Query: 1615 KIEPVLG-IITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIH 1673
+++ + G I T PD + L V D+G+P +SAT V +++ +++ P F
Sbjct: 1577 RMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ 1636
Query: 1674 KDYQAEVNENVD-IGTSVILISAIS-----QSTLIYEVKDGDINGIFTINPYSGVITTQK 1727
Y+ ++E D + TS+I I A+ T+ Y + G+I F I+ + GVIT K
Sbjct: 1637 PHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAK 1696
Query: 1728 ALDYERT-SSYQLIIQATNMA-----GMASNATVNIQIVDENDNAPVFLFSQYSG--SLS 1779
LDYE + Y LI+ AT+ + S TV + + D NDN P F Y G ++
Sbjct: 1697 ELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFP-RDYEGPFEVT 1755
Query: 1780 EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGA--IRTIA 1837
E P + L A D DS N + Y I++ F + G +R
Sbjct: 1756 EGQPGPRVWTFL--------AHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDV 1807
Query: 1838 NLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTY 1897
LD ETIA ++ + RD G P L+ S + V I V D+NDN PV + +
Sbjct: 1808 ELDRETIAFYNLTICARDRGMPPLS--STMLVGIRVLDINDNDPVLLNLPMNITISENSP 1865
Query: 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGSLDH-FLIDSNSGVLTIKNNNLSKD---HYML 1953
V V V A+D DS LT+++ G+ + F I++ +G++T+ N L ++ Y L
Sbjct: 1866 VSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTV-NRPLDRERIPEYKL 1924
Query: 1954 IVKVSDG------KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNA- 2006
+ V D ++ I + + D+ FT+S Y + EN+ T + ++N
Sbjct: 1925 TISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGP 1984
Query: 2007 -----VGNRLNEPLKYSILN-PGNKFKIKSTSGVIQT-TGVPFDRE--EQELYELVVEAS 2057
+ + Y +L F I S++GV+ +GV DRE + EL++ A
Sbjct: 1985 ILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLA- 2043
Query: 2058 RELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNG 2117
E L + + + I D NDN P F + + PG + QVTA D+D G NG
Sbjct: 2044 -EDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNG 2102
Query: 2118 EVTYVLQ-DDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPI 2176
E+ Y ++ F I+ +G + + A Y +T++A D G LS + + I
Sbjct: 2103 ELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTI 2162
Query: 2177 TI--VNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE-----GQGIIYIIIDGDPFK 2229
I +N + P F P T SV E T I +I A + I+ I+ D +
Sbjct: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDR 2222
Query: 2230 -------QFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASD--------ALTGARAEVTVD 2274
F ++ +TG + V SP++ E+ + Y++T+ D +++ A++TV+
Sbjct: 2223 LVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVN 2282
Query: 2275 LLVNDVNDNPPIFDQ---PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHY---QIVQ 2328
+L DVNDN P F Y + E + GT ++ V ++D D N +V Y +V
Sbjct: 2283 VL--DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVP 2340
Query: 2329 DTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVN 2388
Y + DSS+G ++ R +D+E V VR+ D+G P ++E+ V++ I D+N
Sbjct: 2341 PGYVQLE----DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDIN 2396
Query: 2389 DNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKS 2448
DN P+F+Q Y+ V E P G + V A+DADS +F +EYS+ G+ + F ++ +
Sbjct: 2397 DNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTT 2454
Query: 2449 GVITLSNHRKQRMEPLYSLNV-------SVSDGLFTSTAQVHIRVLGANLYSPAFSQSTY 2501
G I + + + + Y L V+ ++ QV I+VL N P FS+ +
Sbjct: 2455 GDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQF 2514
Query: 2502 VAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRE 2561
V EN AGT VI + ATD D G G+++Y++ + F +D + ++TT+R
Sbjct: 2515 STSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP-GVEAFHVDMDSGLVTTQR---- 2569
Query: 2562 NPLEG--DVSIFVRALDGGGRTTFCTVRVI--VVDENDNAPQFMTVEYRA--SVRADVGR 2615
PL+ S+ V A DGG + T ++ V+D NDN P F+ +R ++
Sbjct: 2570 -PLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPL 2628
Query: 2616 GHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLS 2675
V +V A D D+G N + YS A + IDP +G + T ++ V S
Sbjct: 2629 RSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYS 2688
Query: 2676 FFVKAVDGGIPVKH-SLIPVYIHVLPPETFLPSFTQ-----SQYS-FTIAEDTAIGSTVD 2728
+ A D G PV + ++ P+ + + + P F + QY T+ E + G+ V
Sbjct: 2689 LILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG 2748
Query: 2729 TLRIL------PSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFK 2782
+ P+ V++ G +N F + Q G + + + LDRE F F
Sbjct: 2749 NVTGAVDADEGPNAIVYYFIAAGNEEKN-----FHL-QPDGCLLVLRDLDREREAIFSFI 2802
Query: 2783 VAATI---------PLDKVDIVFTV---DVDIKVLDLNDNKPVFETSSYDTIIMEGMPVG 2830
V A+ P +D+V + +V + + D+ND P F + Y + VG
Sbjct: 2803 VKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVG 2862
Query: 2831 TKLTQVRAIDMDWGANGQVTYSLHS-------DSQPEKVMEAFNIDSNTGWISTLKDLDH 2883
++L QV A+D D G N V YS+ + + E V + F + S G + T
Sbjct: 2863 SELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMA 2922
Query: 2884 ETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEV 2928
+ F +VA DL + TA++ + + + + E+
Sbjct: 2923 YSPGYFVVDIVARDLA---GHNDTAIIGIYILRDDQRVKIVINEI 2964
Score = 761 bits (1965), Expect = 0.0
Identities = 802/2971 (26%), Positives = 1298/2971 (43%), Gaps = 300/2971 (10%)
Query: 167 IAESTPLRTSVAQVTATDAD-----IGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNY 221
I+E TP+ +SV Q+ A D D G +GE F F+V P +GV+ L L+
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRF------FAVEPDTGVVWLRQPLDR 95
Query: 222 DEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSL---EK 278
+ K+ + +E D + GV T K+ + + +N++APT H + P+S+ E
Sbjct: 96 ETKSEFTVEFSVSD-------HQGVI-TRKVNIQVGDVNDNAPTFH---NQPYSVRIPEN 144
Query: 279 EPTYA---VVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWE 335
P +V D D GA G + + + P QFF + + + +++D+E
Sbjct: 145 TPVGTPIFIVNATDPDLGAGGSV----LYSFQPPSQFFAIDSARGI----VTVIRELDYE 196
Query: 336 SFPYGYNLTLQAKDKGSPQKCSAL-KAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVV 394
+ Y LT+ A D+ + S L I +D PI F Y +I E SPPG
Sbjct: 197 T-TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPI-FINLPYSTNIYEHSPPGTT 254
Query: 395 VAIVKLSPE----PIDVEYKLSPGEDAVYFKINPRSGLIVTARPLN------------TV 438
V I+ + P + Y + G F ++ SG++ L+ TV
Sbjct: 255 VRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTV 314
Query: 439 KKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSV-LTVSAS 497
K + T + + I + D ND+ PEF Y + E VG ++ L +
Sbjct: 315 KGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVV 374
Query: 498 DKDK--GENGYITYSIASLNLLPFVINQFTGV-------ISTTEELDFESSPEIYRFIVR 548
DKD+ G N + N F+I+ T V I LD+E+ Y F +
Sbjct: 375 DKDENLGLNSMFEVYLVGNNSHHFIISP-TSVQGKADIRIRVAIPLDYETVDR-YDFDLF 432
Query: 549 ASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDEL 608
A++ S H V I + N NDN P+F + + + VG + V A D D
Sbjct: 433 ANE--SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAG 490
Query: 609 ELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSIN 668
+ ++ F L+ D+G++ L L I+ F L I A DG +
Sbjct: 491 TFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQR--FTLTIIARDGGGEETTGRVR 548
Query: 669 ISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKS 728
I+VL +N P F K
Sbjct: 549 INVL--------------------------------------------DVNDNVPTFQKD 564
Query: 729 FPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNT-DSCFNIDMETGQ--LKV 785
A++E+ P +++++A D DS N ++ ++I + S F+I + G + V
Sbjct: 565 AYVG-ALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISV 623
Query: 786 LMPMDREHTDLYLLNITIY--DLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILES 843
P+D E L+ +T+ D GNP +S +TI V D NDN P F + +Y V+++E+
Sbjct: 624 SRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVEN 683
Query: 844 SGIGTEIIQVEARDKDLG---SNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANY 900
G ++ + A D D + YS L + QF IN+ +G + LDRE+K+ Y
Sbjct: 684 IMAGATVLFLNATDLDRSREYGQESIIYS-LEGSTQFRINARSGEITTTSLLDRETKSEY 742
Query: 901 SLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLET 960
L + A D Q + T+ + L D+ND P + + Y + ++E P + + +
Sbjct: 743 ILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVA 802
Query: 961 HDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKEL-------DYEKQQFYNLTVRAK 1013
DPDLG G + YS + N + ++ +G IR + + +E + + V
Sbjct: 803 VDPDLGENGTLVYS-IQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVT 861
Query: 1014 DKGRP-VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDS 1072
D GRP + +S + V V ++D+N+N P F + V V E G S+ QV A D D
Sbjct: 862 DCGRPPLKATSSATVFVNLLDLNDN--DPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDE 919
Query: 1073 GRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTI 1132
G +G + Y + G F I+ SGV+ LDRE + Y L V A+D G ST
Sbjct: 920 GLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTS 979
Query: 1133 EVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNP 1192
+ I V DVND P +Y V E+ P++ V+ + D D N +L+Y IT GN
Sbjct: 980 TLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNV 1039
Query: 1193 QNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVLDENDN 1250
F++ + ++ T LDRE A + L + D GP K+ T V V VLD NDN
Sbjct: 1040 DGKFSVGYRDAVVRTVV-GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
Query: 1251 KPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKT 1310
+P F + Y+ +PE G I + A D DEG + Y I+ GN F I
Sbjct: 1099 RPIFLQSSYEASVPE--DIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSN 1156
Query: 1311 GMVSSRKQ---FTAGSYDILTIKAV--DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEP 1365
G++ + S +L ++A D G + S +++E I P+ +
Sbjct: 1157 GLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDIN----DEAPVFTQQQ 1212
Query: 1366 FYNFTVMESDRVTEIVGVVSVQPANTP----LWFDIVGGNFDSAFDAEKGVGTIVIAKPL 1421
+ + E+ + V VV ++ + + I+ G + F+ ++ G I+ L
Sbjct: 1213 YSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYL 1271
Query: 1422 DAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTE 1478
D E ++ Y M+V TD N V+I +L+ D +FS +Y+ I E++ TE
Sbjct: 1272 DYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTE 1331
Query: 1479 ILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMV 1538
I++++A D ++++Y ++ + + F+ID TGV+ +D E D + L + V
Sbjct: 1332 IVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV-V 1390
Query: 1539 RDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEA-SVFESAALGSAVLQVTALDKDKGE 1597
D P + +V + V D ND+SP F A S+ E +G V V A D D G
Sbjct: 1391 ADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGS 1450
Query: 1598 NAELIYTIEAGNTGNMFKI---EPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSAT 1654
N ++++++ +GN F+I +G + + + D + ++L + +D+G+PP
Sbjct: 1451 NGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKD 1510
Query: 1655 AIVRISVTMSDNSHPKFIHK--DYQAEVNENVDIGTSVILISAISQ-----STLIYEVKD 1707
I+++++ + N +P I Y VNENV GT+V+ + A + S L Y + +
Sbjct: 1511 HILQVTI-LDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE 1569
Query: 1708 GDINGIFTINPYSGVITTQKA-LDYERTSSYQLI--IQATNMAGMASNATVNIQIVDEND 1764
G+ + F ++ SG I T+ A D ER S Y L+ ++ +++ V + IVDEND
Sbjct: 1570 GNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEND 1629
Query: 1765 NAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFF 1824
NAP+F Y L E +L+ S + I+A D D N + Y IV F
Sbjct: 1630 NAPMFQQPHYEVLLDEGPD------TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTF 1683
Query: 1825 TVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG-----SPQLTAESPVEVNIEVTDVNDN 1879
+D G I LD+E I+H + + V + S +LT+ + V VN V D+NDN
Sbjct: 1684 RIDRHMGVITAAKELDYE-ISHGRYTLIVTATDQCPILSHRLTSTTTVLVN--VNDINDN 1740
Query: 1880 PPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGV 1938
P F + + G V A D DS ++ YS+M+G L F+I GV
Sbjct: 1741 VPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGV 1800
Query: 1939 LTI-KNNNLSKD---HYMLIVKVSD---GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSI 1991
L + K+ L ++ Y L + D ST +V I V + D+ + +I
Sbjct: 1801 LRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITI 1860
Query: 1992 SENNTNITKVAIVNA--VGNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQ 2047
SEN+ + VA V A + N L ++I N F I +T+G++ T P DRE
Sbjct: 1861 SENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIV-TVNRPLDRERI 1919
Query: 2048 ELYELVVEASRELDHLRVAR---VVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGT--- 2101
Y+L + ++ R+AR ++ + + D NDN P+F Y A V ++ GT
Sbjct: 1920 PEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLT 1979
Query: 2102 -LIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPN-------SGNVILKEAFNSDLSNI 2152
L + A+D D+ VTY +L G F+IN + SG +I +EAF+ + +
Sbjct: 1980 VLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILEL 2039
Query: 2153 EYGVTILAKDGGKPSLSTSVELPITIV--NKAMPVFDKPFYTASVNEDIRMNTPILSINA 2210
+LA+D G L+++ L ITI+ N P F T + E+ +L + A
Sbjct: 2040 ----LLLAEDIG--LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTA 2093
Query: 2211 TSPEG--QGIIYIIIDGDPFKQFNIDFDTGVLKV-VSPLDYEVTSAYKLTIRASDALT-G 2266
T + G + I+ +F I TGV++V + +D E +Y+LT+ A+D T
Sbjct: 2094 TDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVP 2153
Query: 2267 ARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQI 2326
V +L++D+ND+ P F P ++ E++ GT + + +ID D N + Y I
Sbjct: 2154 LSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NPKLEYHI 2211
Query: 2327 V-----QDT----YNSTDYFHIDSSSGLILTARMLDHELV--QHCTLKVRSIDSGFPSLS 2375
V DT N D F ++ ++G ++ ++ ELV TL V S P S
Sbjct: 2212 VGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERS 2271
Query: 2376 SEV---LVHIYISDVNDNPPVFNQL---IYESYVSELAPRGHFVTCVQASDADSSDFDRL 2429
V + + + DVNDN P F Y + E A G + V A D D +
Sbjct: 2272 VSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLV 2331
Query: 2430 EYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSV---SDGLFTSTAQ--VHI 2484
Y++L ++ S ++N R E ++ LN +V +G A+ V++
Sbjct: 2332 TYTLLDLVPPGYVQLEDSSAGKVIAN-RTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
Query: 2485 RVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRF 2544
++ N +P F Q +Y V E+V GT ++ V ATD D G + I Y++ + + +F
Sbjct: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGD--GESKF 2448
Query: 2545 LID-SNGQVITTERLDRENPLEGDVSIFVRALDGGG------RTTFCTVRVIVVDENDNA 2597
I+ + G + LDRE + + A D G R V + V+D ND
Sbjct: 2449 AINPTTGDIYVLSSLDREK--KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCR 2506
Query: 2598 PQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDN 2657
PQF ++ SV + G V + A D D+G N +TYSL + +D D+
Sbjct: 2507 PQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG----VEAFHVDMDS 2562
Query: 2658 GWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYS--F 2715
G + T+ + S V A DGG P + + V+ P F +
Sbjct: 2563 GLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
Query: 2716 TIAEDTAIGSTVDTLRILPSQNVWFSTVNG---ERPENNKGGIFVIEQETGTIKLDKRLD 2772
I E+ + S V + V + N F+I+ +G I+ +RLD
Sbjct: 2621 HIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLD 2680
Query: 2773 RETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVF-----ETSSYDTI-IMEG 2826
RE+ + + A+ V + + + D++DN+P+F + Y + + E
Sbjct: 2681 RESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEH 2740
Query: 2827 MPVGTKLTQVR-AIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHET 2885
P GT + V A+D D G N V Y + + ++ + F++ + G + L+DLD E
Sbjct: 2741 SPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKN----FHLQPD-GCLLVLRDLDRER 2795
Query: 2886 DPTFTFSVVASD-------LGEAFSLSSTA---LVSVRVT--DINDNAPVFAQEVYRGNV 2933
+ F+F V AS G + +L A L VRV DIND P F + Y V
Sbjct: 2796 EAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGV 2855
Query: 2934 KESDPPGEVVAVLSTWDRDTSDVNRQVSYHI 2964
G + + D D + N V Y I
Sbjct: 2856 ATDAKVGSELIQVLALDADIGN-NSLVFYSI 2885
Score = 696 bits (1795), Expect = 0.0
Identities = 619/2187 (28%), Positives = 994/2187 (45%), Gaps = 154/2187 (7%)
Query: 1564 PYFTNPLYEASVF--ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLG 1621
P+FTN ++ + E +GS+V Q+ A D D N L++ + F +EP G
Sbjct: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
Query: 1622 IITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVN 1681
++ + + D T +F + V+D T V I V +++ P F ++ Y +
Sbjct: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142
Query: 1682 ENVDIGTSVILISAISQS-----TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSS 1736
EN +GT + +++A +++Y + + F I+ G++T + LDYE T +
Sbjct: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP--SQFFAIDSARGIVTVIRELDYETTQA 200
Query: 1737 YQLIIQATNM---AGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDN 1793
YQL + AT+ +++ A + I I D D P+F+ YS ++ E +P + VR
Sbjct: 201 YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---- 256
Query: 1794 SPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHV-- 1851
+I A D D R + Y IV F +D +G + LD E + H +
Sbjct: 257 ---IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILT 313
Query: 1852 ----HVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV-LKVS 1906
+ D +P A NI V D+NDN P F + + + VG + L +
Sbjct: 314 VKGTELNDDRTPS-DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQ 372
Query: 1907 ATDPDSEVPPELTYS--LMEGSLDHFLIDSNSG----------VLTIKNNNLSKDHYMLI 1954
D D + + L+ + HF+I S + + + + + L
Sbjct: 373 VVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLF 432
Query: 1955 VKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNE- 2013
S + V I + D+ F+Q Y+ S+ EN T T V V A N
Sbjct: 433 ANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTF 492
Query: 2014 -PLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRV 2072
+ Y + ++F + +G+I D E + + L + A RV R+
Sbjct: 493 GEVSYFFSDDPDRFSLDKDTGLIMLIA-RLDYELIQRFTLTIIARDGGGEETTGRV--RI 549
Query: 2073 NIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY--VLQDDYG-H 2129
N+ D+NDN P F Y A++ + T + ++ A D+D PN ++TY V +G +
Sbjct: 550 NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY 609
Query: 2130 FEINPNSGNVILKEAFNSDLSNIEYGV---TILAKDGGKPSLSTSVELPITIV--NKAMP 2184
F+I+ G ++ + D I G+ T++A D G P L+++V + I + N P
Sbjct: 610 FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
Query: 2185 VFDKPFYTASVNEDIRMNTPILSINATSPE-----GQGIIYIIIDGDPFKQFNIDFDTGV 2239
F KP Y SV E+I +L +NAT + GQ I ++G QF I+ +G
Sbjct: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST--QFRINARSGE 727
Query: 2240 LKVVSPLDYEVTSAYKLTIRASDALTGARAEV---TVDLLVNDVNDNPPIFDQPTYNTTL 2296
+ S LD E S Y L +RA D G + TV++ + D+NDN P + Y L
Sbjct: 728 ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINL 787
Query: 2297 SEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTAR-MLD-- 2353
E + + V VV++D D N + Y I ++ ++S++G I T MLD
Sbjct: 788 VEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN----KFYSLNSTTGKIRTTHAMLDRE 843
Query: 2354 ----HELVQHCTLKVRSIDSGFPSL--SSEVLVHIYISDVNDNPPVFNQLIYESYVSELA 2407
HE + V D G P L +S V + + D+NDN P F L + + V E
Sbjct: 844 NPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGI 903
Query: 2408 PRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSL 2467
P G + V A D D + Y + G R FL++S SGV+ + + Y L
Sbjct: 904 PAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQL 963
Query: 2468 NVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGD 2524
V SD +ST+ + I VL N +P F + Y V E+V +V+ + TD D
Sbjct: 964 RVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDND 1023
Query: 2525 PGTYGQISYAIINDFAKDRFLIDSNGQVI-TTERLDRENPLEGDVSIFVRALDGGG---- 2579
G ++SY I +F + V+ T LDRE + + A+D G
Sbjct: 1024 VGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAA--YMLILEAIDNGPVGKR 1081
Query: 2580 RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSL 2639
T TV V V+D NDN P F+ Y ASV D+ GH + Q++A D D+G R+ Y +
Sbjct: 1082 HTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI 1141
Query: 2640 YSEASVSVADLLEIDPDNGWMVTKGN-FNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHV 2698
+ + I NG ++ ++ +N+ V+A + + S + V ++V
Sbjct: 1142 LHG---NHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYV 1198
Query: 2699 LPPETFLPSFTQSQYS-FTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFV 2757
P FTQ QYS + E IG++V ++ + VN R + G F
Sbjct: 1199 EDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN-YRILSGAEGKFE 1257
Query: 2758 IEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETS 2817
I++ TG I LD ET ++ V+AT + F V I +L+ D F +
Sbjct: 1258 IDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFC-SVYITLLNELDEAVQFSNA 1316
Query: 2818 SYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWIST 2877
SY+ I+E + +GT++ +V+A +D Q+TY ++ + + F ID+ TG I+
Sbjct: 1317 SYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQ-AKALFKIDAITGVITV 1373
Query: 2878 LKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRG-NVKES 2936
+D E +T +VVA D G + ST V + V D NDN+P F ++ E
Sbjct: 1374 QGLVDREKGDFYTLTVVADDGGP--KVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
Query: 2937 DPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQ-SEWKVYVKRPLDREEQ 2995
P G+ VA + WD D N QV + + GN G F + S +V+V RPLDREE
Sbjct: 1432 CPVGQRVATVKAWDPDAGS-NGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREEL 1490
Query: 2996 DIYFLNITATDGLFVTQA---MVEVSVSDVNDNSPVCDQ-VAYTALLPEDIPSNKIILKV 3051
D Y L + A+D + +++V++ D+NDN PV + Y + E++ +++V
Sbjct: 1491 DHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQV 1550
Query: 3052 SAKDADIGSNGYIRYSLY-GSGNSEFFLDPESGELKTL-ALLDRERIPVYSLMAKATDGG 3109
A D DIG N + Y + G+ + F +D SGE+ T A DRER Y L+A D G
Sbjct: 1551 RATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEG 1610
Query: 3110 GRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYE--NTATKALLTRVQAVDPDIGINRK 3165
+ H+ + D NDN P+F HY + E +T +L+T +QA+D D G N
Sbjct: 1611 TPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLIT-IQALDLDEGPNGT 1669
Query: 3166 VVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE-QQSSYNISVRATDQSP--GQSLSSLTT 3221
V Y++ A + F ID G+I + LD E Y + V ATDQ P L+S TT
Sbjct: 1670 VTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTT 1729
Query: 3222 VTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQ 3281
V + V DINDN P F R + PG +V A +D G N ++ Y I G+
Sbjct: 1730 VLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPL 1789
Query: 3282 GKFKINPKTGGISVSE--VLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPP 3339
G+F I+P G + V + LD E + L + A+D G P LS+ V I + D+NDN P
Sbjct: 1790 GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDP 1849
Query: 3340 KFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVK 3399
+ ISE++ V V ++A D DS N ++ F+I G+R+ F ++ G+V
Sbjct: 1850 VLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVT 1909
Query: 3400 VKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNID-----ISDVNDNSPVFTPANYTAV 3454
V + LDRER+ Y L + D+ P A + D +SD NDN P+FT + Y A
Sbjct: 1910 VNRPLDRERIPEYKLTISVKDN--PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAE 1967
Query: 3455 IQENKPVGTSILQL------VVTDRDSFHNGPPFSFSILSGNEEEEFVLDPHGI--LRSA 3506
+ EN P GT + L + D+D + ++ +L + G+ +RS
Sbjct: 1968 VMENSPAGTPLTVLNGPILALDADQDIY---AVVTYQLLGAQSGLFDINSSTGVVTVRSG 2024
Query: 3507 VVFQHTESLEYV--LCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDD 3564
V+ + L + A+D G +H + + +++++ ++PT P + + +E+
Sbjct: 2025 VIIDREAFSPPILELLLLAEDIGLLNSTAH--LLITILDDNDNRPTFSPATLTVHLLENC 2082
Query: 3565 FPGGVIGKIHATDQD--MYDVLTFALKSEQKSLFKVNSHDGKIIALGGL-----DSGKYV 3617
PG + ++ ATD+D + L + +++ + F ++ G +I +G + Y
Sbjct: 2083 PPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTG-VIRVGNATIDREEQESYR 2141
Query: 3618 LNVSVSDGRFQVPIDVVVHVEQLVHEM 3644
L V +D R VP+ V L+ ++
Sbjct: 2142 LTVVATD-RGTVPLSGTAIVTILIDDI 2167
Score = 689 bits (1778), Expect = 0.0
Identities = 653/2286 (28%), Positives = 1025/2286 (44%), Gaps = 159/2286 (6%)
Query: 1458 PEFSQPNYD--VTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPST 1515
P F+ +D + ISED + + Q+ A D D L + V S R F ++P T
Sbjct: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDND-PLVFGVSGEEAS---RFFAVEPDT 84
Query: 1516 GVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASV 1575
GV++ + LD E + + + V D + R +V + V D ND++P F N Y +
Sbjct: 85 GVVWLRQPLDRETKSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYSVRI 141
Query: 1576 FESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMG 1635
E+ +G+ + V A D D G ++Y+ + + F I+ GI+T+ +E D T
Sbjct: 142 PENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQ 199
Query: 1636 QFVLSIKVTDQGSP-PMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILIS 1694
+ L++ TDQ P+S A + I +T + P FI+ Y + E+ GT+V +I+
Sbjct: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Query: 1695 AISQST-----LIYEVKDGDINGIFTINPYSGVITTQKALDYER---TSSYQLIIQATNM 1746
AI Q + Y + G+ N IF ++ SGV+T LD E + + L ++ T +
Sbjct: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
Query: 1747 AG--MASNATV----NIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRA 1800
S+ATV NI ++D NDNAP F S+YS +++E A + + PL I+
Sbjct: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL------PLFIQV 373
Query: 1801 TDADSNR--NALLVYQIVESTAKKFFTVDSSTGA-----IRTIANLDHETIAHFHFHVHV 1853
D D N N++ +V + + F +S IR LD+ET+ + F +
Sbjct: 374 VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
Query: 1854 RDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSE 1913
+S + +V I + + NDN P+F+Q ++ L VG VL V ATD D+
Sbjct: 434 NESVPDHV---GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAG 490
Query: 1914 VPPELTYSLMEGSLDHFLIDSNSGVLTI---KNNNLSKDHYMLIVKVSDGKFYSTSMVTI 1970
E++Y + D F +D ++G++ + + L + + I+ G +T V I
Sbjct: 491 TFGEVSYFFSDDP-DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRI 549
Query: 1971 MVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL--NEPLKYSILNP---GNK 2025
V + D+ F + Y ++ EN ++T++ + A N + YSI++ G+
Sbjct: 550 NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY 609
Query: 2026 FKIKSTSGV-IQTTGVPFDREE--QELYELVVEASRELDHLRVARVVVRVNIEDINDNSP 2082
F I G + + P D E+ L L V A + + V V + + D NDN P
Sbjct: 610 FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
Query: 2083 VFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPN---GEVTYVLQDDYGHFEINPNSGNV 2139
F Y+ +V + G + + A D D+ + Y L+ F IN SG +
Sbjct: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST-QFRINARSGEI 728
Query: 2140 ILKEAFNSDLSNIEYGVTILAKDGG-----KPSLSTSVELPITIVNKAMPVF-DKPFYTA 2193
+ + + EY + + A DGG K ++T V + + +N P + D P+Y
Sbjct: 729 TTTSLLDRETKS-EYILIVRAVDGGVGHNQKTGIAT-VNITLLDINDNHPTWKDAPYYIN 786
Query: 2194 SVNEDIRMNTPILSINATSPE-GQGIIYIIIDGDPFKQFNIDFDTGVLKVV-------SP 2245
V E ++ + ++ A P+ G+ + P K ++++ TG ++ +P
Sbjct: 787 LV-EMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENP 845
Query: 2246 LDYEVTSAYKLTIRASDA---LTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLI 2302
+E K+ + +D A + TV + + D+NDN P F + + E
Sbjct: 846 DPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
Query: 2303 GTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTL 2362
G + QVV+ID D N +V Y++ F I+SSSG+++T LD E + L
Sbjct: 906 GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD--FLINSSSGVVVTTTELDRERIAEYQL 963
Query: 2363 KVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDAD 2422
+V + D+G P+ SS + I++ DVND P F +Y VSE PR V + +D D
Sbjct: 964 RVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDND 1023
Query: 2423 SSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG-----LFT 2477
L Y I GN F + + V+ + Y L + D T
Sbjct: 1024 VGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHT 1083
Query: 2478 STAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIIN 2537
TA V + VL N P F QS+Y A V E++ G ++ ++ATD D G +G++ Y I++
Sbjct: 1084 GTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILH 1143
Query: 2538 DFAKDRFLID-SNGQVITTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDEND 2595
+ F I SNG ++ R LDRE + + D G + V V V D ND
Sbjct: 1144 GNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDIND 1203
Query: 2596 NAPQFMTVEY-RASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEID 2654
AP F +Y R +R G G V VQA D D G + Y + S A EID
Sbjct: 1204 EAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK----FEID 1259
Query: 2655 PDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYS 2714
G ++T + T V A D P VYI +L F+ + Y
Sbjct: 1260 ESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYE 1319
Query: 2715 FTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKG-GIFVIEQETGTIKLDKRLDR 2773
I E+ A+G+ + ++ N+ T + + +F I+ TG I + +DR
Sbjct: 1320 AAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDR 1379
Query: 2774 ETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTI-IMEGMPVGTK 2832
E + V A KVD TV V I VLD NDN P F+ +S + I E PVG +
Sbjct: 1380 EKGDFYTLTVVADDGGPKVDS--TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQR 1437
Query: 2833 LTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNI---DSNTGWISTLKDLDHETDPTF 2889
+ V+A D D G+NGQV +SL S + + AF I + + G + + LD E +
Sbjct: 1438 VATVKAWDPDAGSNGQVVFSLASGN----IAGAFEIVTTNDSIGEVFVARPLDREELDHY 1493
Query: 2890 TFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEV-YRGNVKESDPPGEVVAVLST 2948
VVASD G ++ V + DINDN PV Y +V E+ G V +
Sbjct: 1494 ILQVVASDRGTP-PRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRA 1552
Query: 2949 WDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL 3008
DRD +N +SY+IT GN F + + E P DRE Q Y L T D
Sbjct: 1553 TDRDIG-INSVLSYYITEGNKDMAFRMDRISGEIATRPAPP-DRERQSFYHLVATVEDEG 1610
Query: 3009 FVTQAM---VEVSVSDVNDNSPVCDQVAYTALLPEDIPS-NKIILKVSAKDADIGSNGYI 3064
T + V V++ D NDN+P+ Q Y LL E + N ++ + A D D G NG +
Sbjct: 1611 TPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTV 1670
Query: 3065 RYSLYGSGN--SEFFLDPESGELKTLALLDRE-RIPVYSLMAKATDG----GGRFCQSNI 3117
Y++ +GN + F +D G + LD E Y+L+ ATD R +
Sbjct: 1671 TYAIV-AGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTT 1729
Query: 3118 HLI-LEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAG- 3175
L+ + D+NDN P F D+ + A D D G N +V YS+ D
Sbjct: 1730 VLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPL 1789
Query: 3176 GVFSIDSSSGIIILEQP--LDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNP 3233
G F I G++ + + LDRE + YN+++ A D+ LSS V I VLDINDN
Sbjct: 1790 GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM-PPLSSTMLVGIRVLDINDND 1848
Query: 3234 PVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGI 3293
PV +T+ E++ + V V A+ D G NA +T+ I +GN + F IN TG +
Sbjct: 1849 PVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIV 1908
Query: 3294 SVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVN-----INLTDVNDNPPKFSQDVYSA 3348
+V+ LD E + L + KD P +A + I L+D NDN P F++ Y A
Sbjct: 1909 TVNRPLDRERIPEYKLTISVKDN--PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQA 1966
Query: 3349 VISEDALVGDSVILL----IAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKK- 3403
+ E++ G + +L +A D D + + ++ G + F ++ G+V V+
Sbjct: 1967 EVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGV 2025
Query: 3404 -LDRERVSG--YSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKP 3460
+DRE S LL+ A D G+ ++STA + I I D NDN P F+PA T + EN P
Sbjct: 2026 IIDREAFSPPILELLLLAEDIGL--LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCP 2083
Query: 3461 VGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPHGILRSA-VVFQHTESLEYVL 3519
G S+LQ+ TD DS NG + I +G ++ + G++R E Y L
Sbjct: 2084 PGFSVLQVTATDEDSGLNGE-LVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRL 2142
Query: 3520 CVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQD 3579
V A D G + + + + + +P + + +E PG VI I A D D
Sbjct: 2143 TVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD 2202
Query: 3580 M-----YDVLTFALKSE-------QKSLFKVNSHDGKIIALGGLDS---GKYVLNVSVSD 3624
+ Y ++ K + Q+ F VN + G ++ ++ Y + +SV D
Sbjct: 2203 LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVID 2262
Query: 3625 GRFQVP 3630
+P
Sbjct: 2263 NASDLP 2268
Score = 607 bits (1564), Expect = e-172
Identities = 633/2224 (28%), Positives = 994/2224 (44%), Gaps = 268/2224 (12%)
Query: 106 RIRTKGGN---SAILNREIQDNYLLIVK---GSVRGEDLEAWTKVNIQVLDMNDLRPLFS 159
RI + G +++L+RE + Y+LIV+ G V VNI +LD+ND P +
Sbjct: 720 RINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWK 779
Query: 160 PTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLS-GR 218
Y + + E TP + V V A D D+G NG Y + +S++ T+G I +
Sbjct: 780 DAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAM 839
Query: 219 LNYDEKNRYDLEIL------AVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHV 272
L+ + + ++ E++ D G +S+A ++V++ +N++ PT + V
Sbjct: 840 LDRENPDPHEAELMRKIVVSVTDCGRPPLK---ATSSATVFVNLLDLNDNDPTFQNLPFV 896
Query: 273 PFSLEKEPT----YAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKE 328
LE P Y VV +D LD+G NG + S + G P F + + +
Sbjct: 897 AEVLEGIPAGVSIYQVVAID-LDEGLNGLV-SYRMPVGMPRMDFLINSSSGVVVTTTELD 954
Query: 329 RKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEF 388
R++I Y L + A D G+P K S D P F VY+VS+SE
Sbjct: 955 RERIA------EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPA-VYNVSVSED 1007
Query: 389 SPPGVVVAIVKLSPEPI----DVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYK 444
P V + + + ++ Y ++ G F + R ++ T L+ Y
Sbjct: 1008 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1067
Query: 445 LEV-------TNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
L + K A V +++ D ND+ P F Q Y+A V E +P G S+L + A+
Sbjct: 1068 LILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKAT 1127
Query: 498 DKDKGENGYITYSIASLNL-LPFVINQFTGVIST-TEELDFESSPEIYRFIVRASDWGSP 555
D D+GE G + Y I N F I+ G++ LD E + + IV A
Sbjct: 1128 DADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSS-HVLIVEA------ 1180
Query: 556 YRHE-----SEVNVTIRIGNVNDNSPLFEKVACQGV-ISYDFPVGGHITAVSAIDIDELE 609
Y H+ S V V + + ++ND +P+F + + + +G + V A D D +
Sbjct: 1181 YNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGD 1240
Query: 610 --LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPM-- 665
LV Y+I+SG E G F ++ +G++ L ++ + ++ATD A P
Sbjct: 1241 GGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYE--TKTSYMMNVSATD---QAPPFNQ 1294
Query: 666 ---SINISVLHGKVSSKSFS--CRETRVAQKLA--------------------------- 693
S+ I++L+ + FS E + + LA
Sbjct: 1295 GFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYT 1354
Query: 694 ---EKLLIKAKA-------NGKLNLEDGFLDFYSI------------------------N 719
K L K A G ++ E G DFY++ N
Sbjct: 1355 STQAKALFKIDAITGVITVQGLVDREKG--DFYTLTVVADDGGPKVDSTVKVYITVLDEN 1412
Query: 720 RQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNI--- 776
P FD + S V++ ED PVG + +KA+D D+G NG+V+F+++ GN F I
Sbjct: 1413 DNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTT 1472
Query: 777 DMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQD-S 835
+ G++ V P+DRE D Y+L + D G P + +L + + D NDN PV
Sbjct: 1473 NDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFG 1532
Query: 836 YSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINS---STGIVYVADQL 892
Y+V++ E+ G GT ++QV A D+D+G N ++Y + + A S I
Sbjct: 1533 YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPP 1592
Query: 893 DRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLP-- 950
DRE ++ Y L D E L + + V + D ND +P F Y V +L++ P
Sbjct: 1593 DRERQSFYHLVATVED--EGTPTLSATTHVYVTIVDENDNAPMFQQPHYEV-LLDEGPDT 1649
Query: 951 VGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYE-KQQFYNL 1008
+ T + ++ D D G G V Y++V + F ID+ G I +KELDYE Y L
Sbjct: 1650 LNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTL 1709
Query: 1009 TVRAKDKGRPVS--LSSVSFVEVEVVDVNENLHTPYFP-DFAVVGSVKENSRIGTSVLQV 1065
V A D+ +S L+S + V V V D+N+N+ P FP D+ V E + G V
Sbjct: 1710 IVTATDQCPILSHRLTSTTTVLVNVNDINDNV--PTFPRDYEGPFEVTE-GQPGPRVWTF 1766
Query: 1066 TARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVI-TAADI-LDRETMGSYWLTVYATDR 1123
A D DSG +G+++YSI DG LG F I GV+ D+ LDRET+ Y LT+ A DR
Sbjct: 1767 LAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1826
Query: 1124 GVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKL 1183
G+ PL ST+ V I V D+NDN P+ + ENSP V + A D DS N +L
Sbjct: 1827 GMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL 1886
Query: 1184 TYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSP---KQSTIWV 1240
T+ IT+GN + F IN TG++ T +R LDRE+ E+ L ++V D +P ++ +
Sbjct: 1887 TFNITAGNRERAFFINATTGIV-TVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLL 1945
Query: 1241 VVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIY----RAFAFDRDEGPNAEISYSIV 1296
++ + DENDN P F + YQ ++ E G P+ A D D+ A ++Y ++
Sbjct: 1946 LIFLSDENDNHPLFTKSTYQAEVME--NSPAGTPLTVLNGPILALDADQDIYAVVTYQLL 2003
Query: 1297 DGNDDGKFFIDPKTGMVSSRK----QFTAGSYDILTIKAVDNGRPQKSSTARLHIEWI-- 1350
G G F I+ TG+V+ R A S IL + + +STA L I +
Sbjct: 2004 -GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDD 2062
Query: 1351 --KKPPPSPIPLT---FDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSA 1405
+P SP LT + F+V++ E G+ N L + I G D
Sbjct: 2063 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGL------NGELVYRIEAGAQD-R 2115
Query: 1406 FDAEKGVGTIVIAK-PLDAEQRSIYNMSVEVTDGTNVAVTQ---VFIKVLDNNDNGPEFS 1461
F G I + +D E++ Y ++V TD V ++ V I + D ND+ PEF
Sbjct: 2116 FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFL 2175
Query: 1462 QPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRK--------FRIDP 1513
P V++ E P T I I A D D KL Y + + + F ++
Sbjct: 2176 NPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
Query: 1514 STGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRR---NLARVIVNVEDANDHSPYFTN 1568
+TG + ++ E + + + V D + P R A++ VNV D ND++P F
Sbjct: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKP 2295
Query: 1569 ---PLYEASVFESAALGSAVLQVTALDKDKGENAELIYT-IEAGNTGNMFKIEPVLGIIT 1624
Y + E A G+ ++ V A+D DKG N + YT ++ G + + G +
Sbjct: 2296 FGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355
Query: 1625 ICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENV 1684
+ D + +++ +D GSPP +A V + + ++++P F YQ V E+V
Sbjct: 2356 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415
Query: 1685 DIGTSVILISAI---SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLII 1741
+GT ++ ++A S + + E GD F INP +G I +LD E+ Y L
Sbjct: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTA 2475
Query: 1742 QATNMAG-MASNATVN-----IQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSP 1795
A + G +ASN N IQ++D ND P F Q+S S+ E P + S
Sbjct: 2476 LAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGT-------SV 2528
Query: 1796 LVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRD 1855
+ + ATD D N L Y + E + F VD +G + T L ++ F V D
Sbjct: 2529 ITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATD 2585
Query: 1856 SGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGV--EVLKVSATDPDSE 1913
G P L + + V EV DVNDN PVF + TIL + + + V +V ATD D
Sbjct: 2586 GGEPPLWGTTMLLV--EVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEG 2643
Query: 1914 VPPELTYSLME--GSLD--HFLIDSNSGVLTI--KNNNLSKDHYMLIVKVSD----GKFY 1963
+ + YS ++ G+ D F+ID SG++ + + S+ Y LI+ SD +
Sbjct: 2644 LNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYE 2703
Query: 1964 STSMVTIMVKEAMDSGLHFTQ------SFYSTSISENNTNITKVAIVNAVGNRLNEP--L 2015
+ + + +++ D+ F + + ++ E++ T V V + P +
Sbjct: 2704 TMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAI 2763
Query: 2016 KYSILNPGNKFKIKSTSGVIQTTGV-----PFDREEQELYELVVEASRE----------- 2059
Y + GN+ K + +Q G DRE + ++ +V+AS
Sbjct: 2764 VYYFIAAGNEEK----NFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP 2819
Query: 2060 -LDHLR-VARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNG 2117
LD + + VRV +EDIND P F Y A V DA+ G+ + QV A+D D G N
Sbjct: 2820 TLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNS 2879
Query: 2118 EVTY 2121
V Y
Sbjct: 2880 LVFY 2883
Score = 466 bits (1199), Expect = e-130
Identities = 477/1819 (26%), Positives = 829/1819 (45%), Gaps = 228/1819 (12%)
Query: 79 IKYRIVSGDEEGFFKAEE----VIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVR 134
+ YRI+SG EG F+ +E +I ++ L+ E + +Y++ V + +
Sbjct: 1244 VNYRILSG-AEGKFEIDESTGLIITVNY--------------LDYETKTSYMMNVSATDQ 1288
Query: 135 GEDL-EAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEF 193
+ + V I +L+ D FS +Y I E+ L T + +V A D + +
Sbjct: 1289 APPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQI 1346
Query: 194 YYYFKNKVD-----LFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSS 248
Y F LF + +GVI++ G ++ ++ + Y L ++A D G K V S
Sbjct: 1347 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPK------VDS 1400
Query: 249 TAKLYVHIERINEHAPTIHVVTHVPFSLEKE----PTYAVVTVDDLDDGANGEIESVSIV 304
T K+Y+ + N+++P + S+ ++ A V D D G+NG++ S+
Sbjct: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVV-FSLA 1459
Query: 305 AGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSP--QKCSALKAV 362
+G+ F + + E + + +D E + Y L + A D+G+P +K L+
Sbjct: 1460 SGNIAGAFEIVTTNDSIGEVFVA--RPLDREELDH-YILQVVASDRGTPPRKKDHILQVT 1516
Query: 363 YIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVE----YKLSPGEDAV 418
+ D P+ Y+VS++E G V V+ + I + Y ++ G +
Sbjct: 1517 ILD--INDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDM 1574
Query: 419 YFKINPRSGLIVTA-RPLNTVKKEVYKLEVT-NKEG----DLKAQVTISIEDANDHTPEF 472
F+++ SG I T P + ++ Y L T EG V ++I D ND+ P F
Sbjct: 1575 AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMF 1634
Query: 473 QQPLYDAYVNESVP-VGTSVLTVSASDKDKGENGYITYSIASLNLL-PFVINQFTGVIST 530
QQP Y+ ++E + TS++T+ A D D+G NG +TY+I + N++ F I++ GVI+
Sbjct: 1635 QQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITA 1694
Query: 531 TEELDFESSPEIYRFIVRASDWGSPYRHE--SEVNVTIRIGNVNDNSPLFEKVACQGVIS 588
+ELD+E S Y IV A+D H S V + + ++NDN P F +
Sbjct: 1695 AKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPR-------D 1747
Query: 589 YDFPV-------GGHITAVSAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSL 639
Y+ P G + A D D V+Y I+ G+ LG F ++P GVL+++K +
Sbjct: 1748 YEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDV 1807
Query: 640 TNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIK 699
D E +A N+++ C R L+ +L+
Sbjct: 1808 ---------------ELDRETIA---FYNLTI-----------CARDRGMPPLSSTMLVG 1838
Query: 700 AKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNG 759
+ IN P + P ++ + E+ PV + + + A DADSG N
Sbjct: 1839 IRV-------------LDINDNDPVL-LNLPMNITISENSPVSSFVAHVLASDADSGCNA 1884
Query: 760 KVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQ-----KSSW 814
++ F I+ GN + F I+ TG + V P+DRE Y L I++ D NP+ + +
Sbjct: 1885 RLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD--NPENPRIARRDY 1942
Query: 815 RLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEII----QVEARDKDLGSNGEVTYSV 870
LL I + D NDN P+F + +Y ++E+S GT + + A D D VTY +
Sbjct: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL 2002
Query: 871 L-TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDV 929
L + F INSSTG+V V + + +A +E AE L S L + + D
Sbjct: 2003 LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDD 2062
Query: 930 NDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKAS 989
ND P F P++ +V +LE+ P G + + D D GL G++ Y + RF I +
Sbjct: 2063 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVT 2122
Query: 990 GAIRL-SKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV 1048
G IR+ + +D E+Q+ Y LTV A D+G V LS + V + + D+N++ P F +
Sbjct: 2123 GVIRVGNATIDREEQESYRLTVVATDRG-TVPLSGTAIVTILIDDINDS--RPEFLNPIQ 2179
Query: 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSI-----RDGSGL------GRFSIDDES 1097
SV E++ GT + +TA D D + +++Y I +D + F+++ +
Sbjct: 2180 TVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINT 2237
Query: 1098 GVITAADILDRETMGSYWLTVYATDRGV-VPLYS----TIEVYIEVEDVNDNAPLTSE-- 1150
G + ++RE + +Y +T+ D +P S ++ + V DVNDN P
Sbjct: 2238 GSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFG 2297
Query: 1151 -PIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS 1209
Y ++E + ++I + A DPD N +TY + P + + + +
Sbjct: 2298 ITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIAN 2357
Query: 1210 RKLDREQQAEHFLEVTV--TDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERD 1267
R +D E+ H+L TV +D G P+ + I V ++++D NDN P F + YQ + E
Sbjct: 2358 RTVDYEE--VHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFE-- 2413
Query: 1268 RKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTG---MVSSRKQFTAGSY 1324
G I A D D G A I YS+ DG + KF I+P TG ++SS + Y
Sbjct: 2414 DVPVGTIILTVTATDADSGNFALIEYSLGDG--ESKFAINPTTGDIYVLSSLDREKKDHY 2471
Query: 1325 DILTIKAVDN----GRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV-TE 1379
ILT A DN ++ ++ ++ I+ + P F +P ++ +V E++ T
Sbjct: 2472 -ILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP---QFSKPQFSTSVYENEPAGTS 2527
Query: 1380 IVGVVSV---QPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVT 1436
++ +++ + N L + + G + AF + G + +PL + ++ ++++V T
Sbjct: 2528 VITMMATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGLVTTQRPLQSYEK--FSLTVVAT 2584
Query: 1437 DGTNV---AVTQVFIKVLDNNDNGPEFSQP--NYDVTISEDVLPDTEILQIEATDRDE-- 1489
DG T + ++V+D NDN P F +P + I E++ + + ++ ATD+DE
Sbjct: 2585 DGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGL 2644
Query: 1490 KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRR 1547
+ Y+ + + F IDP +G++ TA+RLD E+Q + L ++ D Q PY
Sbjct: 2645 NGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPY-E 2703
Query: 1548 NLARVIVNVEDANDHSPYFT-----NPLYE-ASVFESAALGSAVLQVT-ALDKDKGENAE 1600
+ + V +ED +D+ P F +P Y+ +V E + G+ V VT A+D D+G NA
Sbjct: 2704 TMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAI 2763
Query: 1601 LIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGS--PPMSATAI-- 1656
+ Y I AGN F ++P G + + ++ D F +K + S PP +
Sbjct: 2764 VYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLD 2822
Query: 1657 ---------VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI-----SQSTLI 1702
VR+ + ++ P+F +Y A V + +G+ +I + A+ + S +
Sbjct: 2823 LVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882
Query: 1703 YEV-----------KDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMAS 1751
Y + D+ +FT+ G++ T + + I A ++AG
Sbjct: 2883 YSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHND 2942
Query: 1752 NATVNIQIVDENDNAPVFL 1770
A + I I+ ++ + +
Sbjct: 2943 TAIIGIYILRDDQRVKIVI 2961
Score = 226 bits (577), Expect = 3e-58
Identities = 266/997 (26%), Positives = 429/997 (43%), Gaps = 132/997 (13%)
Query: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVS----GDEEGFFKAEEVI 98
FT S Y A V ENS A T + + I +D DI Y +V+ G + G F I
Sbjct: 1959 FTKSTYQAEVMENSPAGTPLTVLNG-PILALDADQDI-YAVVTYQLLGAQSGLFD----I 2012
Query: 99 IADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED---LEAWTKVNIQVLDMNDLR 155
+ + +R + I++RE +L + + ED L + + I +LD ND R
Sbjct: 2013 NSSTGVVTVR----SGVIIDREAFSPPILEL--LLLAEDIGLLNSTAHLLITILDDNDNR 2066
Query: 156 PLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK-NKVDLFSVHPTSGVIS 214
P FSP T +V + E+ P SV QVTATD D G NGE Y + D F +H +GVI
Sbjct: 2067 PTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIR 2126
Query: 215 L-SGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPT-IHVVTHV 272
+ + ++ +E+ Y L ++A DR G +S TA + + I+ IN+ P ++ + V
Sbjct: 2127 VGNATIDREEQESYRLTVVATDR-----GTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
Query: 273 PFSLEKEPTYAVVTVDDLDDGANGEIE--SVSIVAGDPLDQFFLAKEGKW---LNEYKIK 327
EP + + +D N ++E V IVA D D+ +E + +N +
Sbjct: 2182 SVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVM 2241
Query: 328 ERKQIDWESFPYGYNLTLQAKDKGS---------PQKCSALKAVYIGNPTRDTVPIRFEK 378
+ ++ E Y +TL D S P + + + + T P F
Sbjct: 2242 VKSPMNRE-LVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKP--FGI 2298
Query: 379 EVYDVSISEFSPPG-VVVAIVKLSPEP---IDVEYKLSPGEDAVYFKINPRS-GLIVTAR 433
Y I E + PG ++A+ + P+ V Y L Y ++ S G ++ R
Sbjct: 2299 TYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANR 2358
Query: 434 PLNTVKKEVYKLEVTNKEGD-------LKAQVTISIEDANDHTPEFQQPLYDAYVNESVP 486
++ +EV+ L T + D + V + I D ND+ P F QP Y V E VP
Sbjct: 2359 TVD--YEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVP 2416
Query: 487 VGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFI 546
VGT +LTV+A+D D G I YS+ F IN TG I LD E
Sbjct: 2417 VGTIILTVTATDADSGNFALIEYSLGD-GESKFAINPTTGDIYVLSSLDREKKDHYILTA 2475
Query: 547 VRASDWG--SPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAID 604
+ + G + R E+ V V I++ +VND P F K + + P G + + A D
Sbjct: 2476 LAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATD 2535
Query: 605 IDELELVKYKI-ISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLAD 663
DE + + G + F+++ DSG++ ++ L + F+L + ATDG +
Sbjct: 2536 QDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQS----YEKFSLTVVATDG---GE 2588
Query: 664 PMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGP 723
P ++L ++ +N P
Sbjct: 2589 PPLWGTTML---------------------------------------LVEVIDVNDNRP 2609
Query: 724 YFDKSFPSDVA-VKEDLPVGANILKIKAYDADSGFNGKVLFTI--SDGNTD-SCFNIDME 779
F + + ++E++P+ +N+ ++ A D D G NG V ++ + GN D F ID
Sbjct: 2610 VFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPI 2669
Query: 780 TGQLKVLMPMDREHTDLYLLNITIYDLGNP-QKSSWRLLTINVEDANDNSPVFIQDSYS- 837
+G ++ +DRE +Y L + DLG P + + L + +ED +DN P+F++
Sbjct: 2670 SGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGS 2729
Query: 838 -----VNILESSGIGTEIIQVE-ARDKDLGSNGEVTYSVLTDTQQFAIN-SSTGIVYVAD 890
+ + E S GT + V A D D G N V Y + ++ + G + V
Sbjct: 2730 PQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLR 2789
Query: 891 QLDRESKANYSLKIEARDK--------AESGQQLFSVVTL---KVFLDDVNDCSPAFIPS 939
LDRE +A +S ++A L + +TL +V L+D+ND P F +
Sbjct: 2790 DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKA 2849
Query: 940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV 976
Y+ V D VG+ + + D D+G V YS++
Sbjct: 2850 EYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
Score = 210 bits (534), Expect = 3e-53
Identities = 230/919 (25%), Positives = 403/919 (43%), Gaps = 129/919 (14%)
Query: 75 LSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVR 134
L+ ++ YRI +G ++ F +I +R+ +A ++RE Q++Y L V + R
Sbjct: 2100 LNGELVYRIEAGAQDRF-----LIHLVTGVIRV-----GNATIDREEQESYRLTVVATDR 2149
Query: 135 GE-DLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEF 193
G L V I + D+ND RP F +V++ ES T +A +TA D D+ E+
Sbjct: 2150 GTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEY 2209
Query: 194 YYY-----------FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYG 242
+ N+ D F+V+ +G + + +N + Y++ + +D L
Sbjct: 2210 HIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPE 2269
Query: 243 NNGVSSTAKLYVHIERINEHAPTI------HVVTHVPFSLEKEPTYAVVTVDDLDDGANG 296
+ AKL V++ +N++ P + + + T V D D G NG
Sbjct: 2270 RSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNG 2329
Query: 297 EIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKC 356
+ + D + ++ E + K+ + +D+E + N T++A D GSP +
Sbjct: 2330 LVTYTLL---DLVPPGYVQLEDS--SAGKVIANRTVDYEEVHW-LNFTVRASDNGSPPRA 2383
Query: 357 SALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID----VEYKLS 412
+ + D PI F++ Y ++ E P G ++ V + +EY L
Sbjct: 2384 AEIPVYLEIVDINDNNPI-FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLG 2442
Query: 413 PGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKE--GDLKA-------QVTISIE 463
GE F INP +G I L+ KK+ Y L K+ GD+ + QV I +
Sbjct: 2443 DGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVL 2500
Query: 464 DANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQ 523
D ND P+F +P + V E+ P GTSV+T+ A+D+D+G NG +TYS+ + F ++
Sbjct: 2501 DVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDM 2560
Query: 524 FTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVAC 583
+G+++T L S E + V A+D G P + + + + + +VNDN P+F +
Sbjct: 2561 DSGLVTTQRPL---QSYEKFSLTVVATDGGEPPLWGTTM-LLVEVIDVNDNRPVFVRPPN 2616
Query: 584 QGV--ISYDFPVGGHITAVSAIDIDE--LELVKYKII--SGN-ELGFFYLNPDSGVLQLK 636
+ I + P+ ++ V A D DE V+Y + +GN + FF ++P SG++Q
Sbjct: 2617 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTA 2676
Query: 637 KSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKL 696
+ L ++L + A+D L P+ ET ++A +
Sbjct: 2677 QRLDRE--SQAVYSLILVASD---LGQPVPY-----------------ETMQPLQVALE- 2713
Query: 697 LIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIK-AYDADS 755
+++D F + P + + V E P G + + A DAD
Sbjct: 2714 ----------DIDDNEPLFVRPPKGSPQYQL-----LTVPEHSPRGTLVGNVTGAVDADE 2758
Query: 756 GFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDL--YLLNITIYDLGNPQKS- 812
G N V + I+ GN + F++ + G L VL +DRE + +++ + P +
Sbjct: 2759 GPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGP 2817
Query: 813 ----------SWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS 862
+ + + + +ED ND P F + Y+ + + +G+E+IQV A D D+G+
Sbjct: 2818 SPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGN 2877
Query: 863 NGEVTYSVL---------TDT----QQFAINSSTGIVYVADQLDRESKANYSLKIEARDK 909
N V YS+L D+ Q F + S GI+ D S + + I ARD
Sbjct: 2878 NSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDL 2937
Query: 910 AESGQQLFSVVTLKVFLDD 928
A G +++ + + DD
Sbjct: 2938 A--GHNDTAIIGIYILRDD 2954
Score = 129 bits (324), Expect = 7e-29
Identities = 156/592 (26%), Positives = 259/592 (43%), Gaps = 65/592 (10%)
Query: 73 IDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGS 132
+ L+ ++ Y I G+ +G F + +RT G L+RE Y+LI++
Sbjct: 1024 VGLNAELSYFITGGNVDGKFSV------GYRDAVVRTVVG----LDRETTAAYMLILEAI 1073
Query: 133 VRGEDLEAWT---KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
G + T V + VLD+ND RP+F ++Y ++ E P S+ Q+ ATDAD G
Sbjct: 1074 DNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGE 1133
Query: 190 NGEFYYYFK--NKVDLFSVHPTSGVISLSGR-LNYDEKNRYDLEILAVDRGMKLYGNNGV 246
G +Y N + F +H ++G++ R L+ + + + L + A + + +
Sbjct: 1134 FGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL-----GPM 1188
Query: 247 SSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEP----TYAVVTVDDLDDGANGEIESVS 302
S+ ++ V++E IN+ AP + L + + VV D D G +G + +
Sbjct: 1189 RSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG-DGGLVNYR 1247
Query: 303 IVAGDPLDQFFLAKEGKWLNEYK---IKERKQIDWESFPYGYNLTLQAKDKGSPQKCSAL 359
I++G EGK+ + I +D+E+ Y + + A D+ P
Sbjct: 1248 ILSG---------AEGKFEIDESTGLIITVNYLDYET-KTSYMMNVSATDQAPPFN-QGF 1296
Query: 360 KAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID----VEYKLSP-- 413
+VYI ++F Y+ +I E G IV++ ID + Y+ +
Sbjct: 1297 CSVYITLLNELDEAVQFSNASYEAAILENLALGT--EIVRVQAYSIDNLNQITYRFNAYT 1354
Query: 414 -GEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG----DLKAQVTISIEDANDH 468
+ FKI+ +G+I ++ K + Y L V +G D +V I++ D ND+
Sbjct: 1355 STQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDN 1414
Query: 469 TPEFQQPLYDAY-VNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP----FVINQ 523
+P F A + E PVG V TV A D D G NG + +S+AS N+ N
Sbjct: 1415 SPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTND 1474
Query: 524 FTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVAC 583
G + LD E + Y V ASD G+P R + + + + I ++NDN P+ E
Sbjct: 1475 SIGEVFVARPLDREEL-DHYILQVVASDRGTPPRKKDHI-LQVTILDINDNPPVIESPFG 1532
Query: 584 QGVISYDFPVGGHITAVSA----IDIDELELVKYKIISGNELGFFYLNPDSG 631
V S + VGG V DI ++ Y I GN+ F ++ SG
Sbjct: 1533 YNV-SVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISG 1583
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 880 bits (2275), Expect = 0.0
Identities = 814/2881 (28%), Positives = 1304/2881 (45%), Gaps = 215/2881 (7%)
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS---DGNTDSCFNIDMETGQLKVLMP 788
D+ + E+ P G I I A +G +++ IS + ID +G ++
Sbjct: 48 DLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARV 106
Query: 789 MDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGT 848
+DRE D Y D + +T+ V D ND++P F Q ++ + E + GT
Sbjct: 107 LDREQRDRYRFTAVTPDGATVE------VTVRVADINDHAPAFPQARAALQVPEHTAFGT 160
Query: 849 EIIQVEARDKDLGSNGEVTYSVLTDT--QQFAINSSTGI-------VYVADQLDRESKAN 899
ARD D G G Y++ D + F + + G + V +LDRE++++
Sbjct: 161 RYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSH 220
Query: 900 YSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLE 959
Y L++EA D ++ ++ L V L D+ND +PAF S Y V E L G+ + +
Sbjct: 221 YMLQLEAYDGGSPPRRAQAL--LDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVF 278
Query: 960 THDPDLGLGGQVRYSL---VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKG 1016
D D G+ G V Y + ++ +G F ID +G ++L + LD+E+++ + L V+A+D G
Sbjct: 279 ASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGG 338
Query: 1017 RPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGS--VKENSRIGTSVLQVTARDEDSGR 1074
L S +FV V V D N+N + + GS V E + G V +++ D D G
Sbjct: 339 AHPELGS-AFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGD 397
Query: 1075 DGEIQYSIRDGSGLGRFSIDDESGVI---TAADILDRETMGSYWLTVYATDRGVVPLYST 1131
+ S+ G G F++ + VI A LDRE +Y L V ATD G PL +
Sbjct: 398 FAHVNVSLEGGEG--HFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE 455
Query: 1132 IEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVS-VIQIQAEDPDSSSNEKLTYRITSG 1190
+ V DVNDNAP +Y P + S V+++ A DPD +N ++TY + G
Sbjct: 456 AAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPG 515
Query: 1191 NPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDN 1250
++F+I+ +G+ITT + LD E + + L V TDGG P S+ V V + D NDN
Sbjct: 516 AHTHWFSIDPTSGIITTAA-SLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDN 574
Query: 1251 KPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDG---NDDGKFFID 1307
+PQF Y LPE + G + A D D GP +SYS+ G + F ID
Sbjct: 575 EPQFQRTFYNASLPEGTQP--GTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRID 632
Query: 1308 PKTGMVSSRKQFTA----GSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFD 1363
+G V + + S+D T+ AVD G + ++ + PP P +
Sbjct: 633 AHSGDVCTTRTLDRDQGPSSFDF-TVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYA 691
Query: 1364 EPFYNFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKP 1420
+S T ++ + + P ++ L + I+ GN F ++ G + +A P
Sbjct: 692 ASIS----AQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWP 747
Query: 1421 LDAEQRSIYNMSVEVTDGTNVAV---TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDT 1477
L S+ + + DG + +V I ++ P F Q Y ++ EDV P T
Sbjct: 748 LARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGT 807
Query: 1478 EILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIM 1537
+ ++A + +L+ S F +D +G+L T LD E +L +
Sbjct: 808 SVGIVQA--HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGP-VLELE 864
Query: 1538 VR-DQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKG 1596
VR P +ARV V ++D ND+SP F P + + A G+ + + ALD D G
Sbjct: 865 VRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSG 924
Query: 1597 ENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAI 1656
N+ + +T+ AG G F ++P G + + + + L ++ D GSPP T+
Sbjct: 925 VNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPR--TSH 981
Query: 1657 VRISVTMSD----NSHPKFIHKDYQAEVNENVDIGTSVILISAISQS--TLIYEVKDGDI 1710
R+ V + D P+F Y+ ++ GT V+ + A + + Y +
Sbjct: 982 FRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGA 1041
Query: 1711 NGIFTINPYSGVITTQKALDYERTSSYQLIIQATN-----MAGMASNATVNIQIVDENDN 1765
+ F + P SG + + ALD E Y L + A + + ATV + I+++N++
Sbjct: 1042 SSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEH 1101
Query: 1766 APVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVE-STAKKFF 1824
+P +++E P + V + ATD DS N L Y + + S K F
Sbjct: 1102 SPRLSEDPTFLAVAENQPPGTSVGR-------VFATDRDSGPNGRLTYSLQQLSEDSKAF 1154
Query: 1825 TVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFT 1884
+ TG + T+ LD E + + V V+D GSP + V V V D+NDN P F
Sbjct: 1155 RIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHV--AVLDLNDNSPTFL 1212
Query: 1885 QAVFETILLLPTYV------GVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGV 1938
QA LP V G V + A DPD + Y+L + F + +SG
Sbjct: 1213 QASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGE 1272
Query: 1939 LTIKNNNL--SKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNT 1996
L + + HY+L + D S ++ + + S + + +
Sbjct: 1273 LLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSA-RLAEPPPDLAERDPAA 1331
Query: 1997 NITKVAIVNAV-----GNRLN-----EP-----LKYSIL---NPGNKFKIKSTSGVIQTT 2038
+ V V A G+ L EP L Y+++ +P F + + SG +
Sbjct: 1332 PVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLA 1391
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
P D E + + + + V+V ++D N+++P F P A+ + E
Sbjct: 1392 R-PLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPE 1450
Query: 2099 PGTLIYQVTAIDKD-KGPNGEVTYVL---QDDYGHFEINPNSGNVILKEAFNSDLSNIEY 2154
PG +Y A D D GPN +V Y L + ++ +G + + + +
Sbjct: 1451 PGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTP--- 1507
Query: 2155 GVTILAKDGGKPSLST-------SVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILS 2207
+ +L + +P+ ++ S + +T N PVF P + ED L
Sbjct: 1508 ALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALH 1566
Query: 2208 INATSP---EGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDAL 2264
+ A P E + Y + G F + TG L VV PLD E + + LT+ ASD
Sbjct: 1567 VVARDPDLGEAARVSYRLASGGD-GHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHG 1625
Query: 2265 TGARAEVTV-DLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVH 2323
+ R+ V + V DVND P F Q Y+ L E + GT +L + + D D N V
Sbjct: 1626 SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVT 1685
Query: 2324 YQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIY 2383
Y V S++ F +D +G++ T R LD E + L V + D G P + V V +
Sbjct: 1686 YGGV-----SSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVA 1740
Query: 2384 ISDVNDNPPVFNQLIYESYVSELAPRGH---FVTCVQASDADSSDFDRLEYSILSGNDRT 2440
+ D ND+ P F +++S P G +T ++ASD D +L+Y IL G+
Sbjct: 1741 VEDENDHAPTFGS----AHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSG 1796
Query: 2441 SFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG---LFTSTAQVHIRVLGANLYSPAFS 2497
+F++D SG + +EP + L + DG ++T + + VL AN ++PAF
Sbjct: 1797 AFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856
Query: 2498 QSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTER 2557
Y EV E+V AGT ++ ++A D D G G ++Y + A L S+G++ T
Sbjct: 1857 VPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAA 1916
Query: 2558 LDRENPLEGDVSIFVRALDG---GGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
LDRE S V A+DG G +T +V + V D ND+AP F T R +
Sbjct: 1917 LDREQCPSYTFS--VSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGP 1974
Query: 2615 RGHLVT----QVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLK 2670
T ++A D D GAN+ I Y L +D G + + L
Sbjct: 1975 SFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTT----VDSYTGEIRVARSPVALG 2030
Query: 2671 NTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTL 2730
F+ A D G P + + + + + P F ++ TI E+ G+ + +
Sbjct: 2031 PRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSP 2090
Query: 2731 RILPSQN----VWFSTVNGERPENNKGGIFVIEQETG--TIKLDKRLDRETSPAFHFKVA 2784
R + + + +S ++G N+ G F I+ TG T++ + LD E SP +
Sbjct: 2091 RAVHAGGTNGPITYSILSG-----NEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQ 2145
Query: 2785 ATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWG 2844
A FTV + + + D NDN P F Y + E P+ L QV A D+D G
Sbjct: 2146 AE---SGGAFAFTV-LTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQG 2201
Query: 2845 ANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSL 2904
+ GQ++YSL + SQP + + F++D TG I+T LD E ++A+D G +L
Sbjct: 2202 SGGQISYSLAA-SQPARGL--FHVDPTTGTITTTAILDREIWAETRLVLMATDRGSP-AL 2257
Query: 2905 SSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHI 2964
+A ++V V D NDN P Q + V E G +A ++ D D+ V + Y +
Sbjct: 2258 VGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPV---LWYVL 2313
Query: 2965 TGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQAMVEVSVSDVND 3024
+ P+ F++G +V + PLD E+ D Y L + A DG +A + V V DVND
Sbjct: 2314 SPSGPQDPFSVGRYGG--RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVND 2371
Query: 3025 NSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGE 3084
N+P Q Y +L E P IL VSA D D G+NG+I Y L + F +DP +G
Sbjct: 2372 NAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADG-FSVDPNNGT 2430
Query: 3085 LKTLA---LLDRERIPVYSLMAKATDGG--GRFCQSNIHLILEDVNDNPPVFSSDHYNTC 3139
L T+ L + ++ +A D G GR ++ +H+ L+D ND+ P F+ HY
Sbjct: 2431 LFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVA 2490
Query: 3140 VYENTATKALLTRVQAVDPDIGINRKVV-YSL-ADSAGGVFSIDS--------------S 3183
V E+ + L ++A D D + V YS+ + + G VF ++ +
Sbjct: 2491 VTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRA 2550
Query: 3184 SGIIILEQPLDREQQSSYNISVRATDQS-PGQSLSSLTTVTITVLDINDNPPVFERRDYL 3242
G ++L +PLD E + YN++V A D+ P QS S+ VT+TVLD+NDNPPVF R Y
Sbjct: 2551 LGCLVLLEPLDFESLTQYNLTVAAADRGQPPQS--SVVPVTVTVLDVNDNPPVFTRASYR 2608
Query: 3243 VTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYE 3302
VTVPEDT G ++L V A+ D G + + + + SG+ G F+++ +G + ++ LD E
Sbjct: 2609 VTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCE 2668
Query: 3303 LCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVIL 3362
R LVV+A D A A+A V I + DVND+ P F ++ S ++E+ G V
Sbjct: 2669 TQARHQLVVQAAD-PAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTT 2727
Query: 3363 LIAEDVDSQPNGQIHFSIVNGDRDNE----FTVDPVLGLVKVKKKLDRERVSGYSLLVQA 3418
L A D D+ G++ +S++ E F ++ G ++ + D E + LLV A
Sbjct: 2728 LHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGA 2787
Query: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
D+G +S++ TV++ ++ ++ PVF + + E G S+ + TD D +
Sbjct: 2788 ADAG--NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGAD 2845
Query: 3479 G 3479
G
Sbjct: 2846 G 2846
Score = 773 bits (1995), Expect = 0.0
Identities = 771/2793 (27%), Positives = 1226/2793 (43%), Gaps = 206/2793 (7%)
Query: 718 INRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNID 777
IN P F ++ + + V E G A DAD+G G + +S F ++
Sbjct: 136 INDHAPAFPQARAA-LQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLE 194
Query: 778 METG-------QLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPV 830
G +L V +DRE+ Y+L + YD G+P + + LL + + D ND++P
Sbjct: 195 TRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPA 254
Query: 831 FIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ----FAINSSTGIV 886
F Q Y + ES G+ ++QV A D D G NG VTY + + F+I++ TG++
Sbjct: 255 FNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLL 314
Query: 887 YVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPA----FIPSSYS 942
+ LD E + + L ++ARD + + VT+ V D ND P+ F+ + S
Sbjct: 315 QLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHV--RDANDNQPSMTVIFLSADGS 372
Query: 943 VKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRL---SKELD 999
+V E P G ++A + DPD G V SL G F + I L ++ LD
Sbjct: 373 PQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGG-EGHFALSTQDSVIYLVCVARRLD 431
Query: 1000 YEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNEN-------LHTPY-FPDFAVVGS 1051
E++ YNL V A D G P + +FV + V DVN+N L+ P P+ A+ GS
Sbjct: 432 REERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVALPGS 490
Query: 1052 VKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETM 1111
V++VTARD D G +G++ YS+ G+ FSID SG+IT A LD E
Sbjct: 491 F---------VVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELE 541
Query: 1112 GSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQ 1171
L V ATD G+ PL S+ V + ++DVNDN P Y + E + +Q+
Sbjct: 542 PQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVT 601
Query: 1172 AEDPDSSSNEKLTYRI-----TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHF-LEVT 1225
A D DS L+Y + +SG+P F I+ +G + TT R LDR+Q F VT
Sbjct: 602 ATDADSGPFGLLSYSLGAGLGSSGSPP--FRIDAHSGDVCTT-RTLDRDQGPSSFDFTVT 658
Query: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
DGG +S ++V V + DENDN PQF + Y + + G + R A D D+
Sbjct: 659 AVDGGGL--KSMVYVKVFLSDENDNPPQFYPREYAASISAQSPP--GTAVLRLRAHDPDQ 714
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFT--AGSYDILTIKAVDNGRPQKSSTA 1343
G + +SY I+ GN F +D ++G+++ A S L I A D G Q +A
Sbjct: 715 GSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSA 774
Query: 1344 RLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQ--PAN-TPLWFDIVGG 1400
R+ I + P +P P F++ Y F+V E VG+V P P+ + GG
Sbjct: 775 RVDISIV---PGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGG 831
Query: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNV----AVTQVFIKVLDNNDN 1456
+ F + G + +PLD E + +EV G+ V AV +V + + D NDN
Sbjct: 832 DPRGLFSLDAVSGLLQTLRPLDRELLGPV-LELEVRAGSGVPPAFAVARVRVLLDDVNDN 890
Query: 1457 GPEFSQPNYDVTISEDVLPDTEILQIEATDRDE--KHKLSYTVHSSIDSISMRKFRIDPS 1514
P F P V + + P T I + A D D ++++T+ + F +DP+
Sbjct: 891 SPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA----FTVDPT 946
Query: 1515 TGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDH--SPYFTNPLYE 1572
TG + L H L + RD P R + R+ V V+D +P F +P Y
Sbjct: 947 TGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYR 1006
Query: 1573 ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMT 1632
+ G+ VLQV A D G + Y + A + F +EP G + + D
Sbjct: 1007 VDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDRE 1063
Query: 1633 TMGQFVLSIKVTDQGSPPM---SATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTS 1689
++L + + + TA VR+S+ + P+ V EN GTS
Sbjct: 1064 AQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTS 1123
Query: 1690 VILISAISQST-----LIYEVKD-GDINGIFTINPYSGVITTQKALDYERTSSYQLIIQA 1743
V + A + + L Y ++ + + F I+P +G +TT + LD E+ SSYQL++Q
Sbjct: 1124 VGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQV 1183
Query: 1744 TNMAG--MASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLV-IRA 1800
+ ++ TV++ ++D NDN+P FL Q SG+ PI R + + ++A
Sbjct: 1184 QDGGSPPRSTTGTVHVAVLDLNDNSPTFL--QASGAAGGGLPIQVPDRVPPGTLVTTLQA 1241
Query: 1801 TDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQ 1860
D D N ++Y + + F++ +G + T A L H+ + D GSP
Sbjct: 1242 KDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPP 1300
Query: 1861 LTAESPVEVNI-EVTDVNDNPPVFTQ----AVFETILLLPTYVGVEV--LKVSATDPDSE 1913
+A + V + + + PP + A +L + G+ L S P+
Sbjct: 1301 RSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPA 1360
Query: 1914 VPPELTYSLMEGSLDH--FLIDSNSGVLTIKNN---NLSKDHYMLIVKVSD--GKFYSTS 1966
LTY+L+ G+ F +D+ SG L + L V+ G
Sbjct: 1361 GVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLL 1420
Query: 1967 MVTIMVKEAMDSGLHFTQSFYSTSISEN---NTNITKVAIVNAVGNRLNEPLKYSILN-- 2021
V + V++ + F + + ++ EN + +A G N ++Y +L
Sbjct: 1421 RVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQE 1480
Query: 2022 -PGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEAS---RELDHLRVARVVVRVNIEDI 2077
P ++ + +G + DRE L+VEA+ R ARV RV + D
Sbjct: 1481 PPVPALRLDARTGALSAPR-GLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDE 1539
Query: 2078 NDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDY-GHFEINPNS 2136
NDN+PVF P + D PG V A D D G V+Y L GHF ++ ++
Sbjct: 1540 NDNAPVFAS-PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSST 1598
Query: 2137 GNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI--VNKAMPVFDKPFYTAS 2194
G + + + + E+ +T++A D G P S + L +++ VN P F + Y+
Sbjct: 1599 GALSVVRPLDRE-QRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVL 1657
Query: 2195 VNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAY 2254
+ E+ T +L++ AT P+ + G + F++D DTGVL + LD E
Sbjct: 1658 LRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEI 1717
Query: 2255 KLTIRASDALTGAR-AEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSID 2313
LT+ A D + + VTV + V D ND+ P F + + E T + S D
Sbjct: 1718 NLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRAS-D 1776
Query: 2314 ADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPS 2373
D N + Y+I+ + + F +D +SG T R LD E+ L++ + D G P+
Sbjct: 1777 PDVGANGQLQYRILDG--DPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPA 1834
Query: 2374 LSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSI 2433
LS+ +L+ + + D ND+ P F Y V E P G + +QA D D+ + Y +
Sbjct: 1835 LSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL 1894
Query: 2434 LSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL----FTSTAQVHIRVLGA 2489
+G +FL++ SG + + + P Y+ +VS DG ++T V I V
Sbjct: 1895 GAGT-AGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDV 1953
Query: 2490 NLYSPAFSQSTYVAEV-RENVAAGTKVIHV---RATDGDPGTYGQISYAIINDFAKDRFL 2545
N ++P F S + R + T + + RA D D G I Y + +
Sbjct: 1954 NDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTV 2013
Query: 2546 IDSNGQVITTERLDRENPLEG--DVSIFVRALDGGGRTTFCTVRVIV--VDENDNAPQFM 2601
G++ R+ R G D +F+ A D G T +IV E + P+F
Sbjct: 2014 DSYTGEI----RVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFP 2069
Query: 2602 TVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMV 2661
A++R + G + +A+ G N ITYS+ S I P G +
Sbjct: 2070 RASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGT---FSIQPSTGAIT 2125
Query: 2662 TKG--NFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAE 2719
+ + + L ++A GG + + + + P F + Y + E
Sbjct: 2126 VRSAEGLDFEVSPRLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPE 2182
Query: 2720 DTAIGSTV-----DTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRE 2774
+ + D L + +S + G+F ++ TGTI LDRE
Sbjct: 2183 SRPLEGPLLQVEADDLDQGSGGQISYSLAASQPAR----GLFHVDPTTGTITTTAILDRE 2238
Query: 2775 TSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLT 2834
+ AT +V + + + V+D NDN+P ++ + E +G+++
Sbjct: 2239 IWAETRLVLMAT-DRGSPALVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDALLGSEIA 2296
Query: 2835 QVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVV 2894
QV D+D +G V + + S S P+ + F++ G +S LD E + ++
Sbjct: 2297 QVTGNDVD---SGPVLWYVLSPSGPQ---DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLL 2350
Query: 2895 ASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTS 2954
A D A ++V V D+NDNAP F+Q +Y+ + E PPG + +S DRD S
Sbjct: 2351 AHDGPH----EGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRD-S 2405
Query: 2955 DVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKR-PLDREEQDIYFLNITATDGLF---V 3010
N +SYH+ +P F++ V L + + + A D
Sbjct: 2406 GANGHISYHLA--SPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRA 2463
Query: 3011 TQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIG-SNGYIRYSLY 3069
+A V V + D ND++P Y + ED+P +L + A DAD S+ + YS+
Sbjct: 2464 ARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSII 2523
Query: 3070 -GSGNSEFFLDP---ESGE-----------LKTLALLDRERIPVYSLMAKATDGGGRFCQ 3114
G+ F L+P E+GE L L LD E + Y+L A D G
Sbjct: 2524 SGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQS 2583
Query: 3115 SNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLAD 3172
S + + + DVNDNPPVF+ Y V E+T A L V+A D D G + V ++++
Sbjct: 2584 SVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSS 2643
Query: 3173 S-AGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDIND 3231
G+F +D SSG + L LD E Q+ + + V+A D P + +L VTI V D+ND
Sbjct: 2644 GDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD--PAGAHFALAPVTIEVQDVND 2701
Query: 3232 NPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITY-LIRSG-NEQGK--FKIN 3287
+ P F +V E+ PGT V + A D G + Y L+ +G +G+ F +N
Sbjct: 2702 HGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALN 2761
Query: 3288 PKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYS 3347
TG + DYE + F L+V A D G LSA TV++ +T ++ P F +
Sbjct: 2762 SSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLAPAFH 2819
Query: 3348 AVISEDALVGDSVILLIAEDVDSQPNGQIHFSI 3380
+ E A G S+ + A D D +G + +S+
Sbjct: 2820 FQVPEGARRGHSLGHVQATDEDGGADGLVLYSL 2852
Score = 761 bits (1966), Expect = 0.0
Identities = 792/2963 (26%), Positives = 1281/2963 (43%), Gaps = 289/2963 (9%)
Query: 478 DAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNL----LPFVINQFTGVISTTEE 533
D ++E P GT + +SA G + Y I++ I++ +GV+ T
Sbjct: 48 DLQIDEEQPAGTLIGDISAG-LPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARV 106
Query: 534 LDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPV 593
LD E YRF D + V VT+R+ ++ND++P F + +
Sbjct: 107 LDREQRDR-YRFTAVTPDGAT-------VEVTVRVADINDHAPAFPQARAALQVPEHTAF 158
Query: 594 GGHITAVSAIDIDELEL-VKYKIISGNELGFFYL-----NPD-SGVLQLKKSLTNSGIKN 646
G A D D L + +SG+ G + PD + V +L +
Sbjct: 159 GTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR 218
Query: 647 GNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKL 706
++ L++ A DG + R AQ L + L+
Sbjct: 219 SHYMLQLEAYDGGS------------------------PPRRAQALLDVTLL-------- 246
Query: 707 NLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS 766
IN P F++S V V E L G+ +L++ A DAD+G NG V + I+
Sbjct: 247 ----------DINDHAPAFNQSRYHAV-VSESLAPGSPVLQVFASDADAGVNGAVTYEIN 295
Query: 767 --DGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDA 824
D F+ID TG L++ P+D E ++ L + D G + +T++V DA
Sbjct: 296 RRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDA 355
Query: 825 NDNSP----VFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAIN 880
NDN P +F+ S + E++ G + ++ D D G V S+ FA++
Sbjct: 356 NDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALS 415
Query: 881 SSTGIVY---VADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI 937
+ ++Y VA +LDRE + Y+L++ A D + + L V DVND +PAF
Sbjct: 416 TQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHV--TDVNDNAPAFD 473
Query: 938 PSSYSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLS 995
Y + L ++ + G+ + + DPD G GQV YSL + F ID SG I +
Sbjct: 474 RQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTA 533
Query: 996 KELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKEN 1055
LDYE + L V A D G P L+S + V V + DVN+N P F S+ E
Sbjct: 534 ASLDYELEPQPQLIVVATDGGLP-PLASSATVSVALQDVNDN--EPQFQRTFYNASLPEG 590
Query: 1056 SRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGR-----FSIDDESGVITAADILDRET 1110
++ GT LQVTA D DSG G + YS+ G+GLG F ID SG + LDR+
Sbjct: 591 TQPGTCFLQVTATDADSGPFGLLSYSL--GAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQ 648
Query: 1111 -MGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQ 1169
S+ TV A D G L S + V + + D NDN P Y + SP +V++
Sbjct: 649 GPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLR 706
Query: 1170 IQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDG 1229
++A DPD S+ +L+Y I +GN F ++ ++GL+T + L R + LE+ DG
Sbjct: 707 LRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTV-AWPLARRANSVVQLEIGAEDG 765
Query: 1230 GPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNA 1289
G + + V + ++ P F + Y +PE I +A G A
Sbjct: 766 GGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAH---NPPGRLA 822
Query: 1290 EISYSIVDGNDDGKFFIDPKTGMVSSRKQFTA---GSYDILTIKAVDNGRPQKSSTARLH 1346
++ S+ G+ G F +D +G++ + + G L ++A +G P + AR+
Sbjct: 823 PVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRA-GSGVPPAFAVARVR 881
Query: 1347 I---------------EWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANT 1391
+ E PP+ P T P Y ++ D GV N+
Sbjct: 882 VLLDDVNDNSPAFPAPEDTVLLPPNTAPGT---PIYTLRALDPDS-----GV------NS 927
Query: 1392 PLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVF---I 1448
+ F ++ G AF + G + + +PL + + +E DG + T F +
Sbjct: 928 RVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRV 986
Query: 1449 KVLDNNDNG--PEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISM 1506
V D G P F+ P Y V + T++LQ++A D T H + + S
Sbjct: 987 VVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PITYHLAAEGASS 1043
Query: 1507 RKFRIDPSTGVLYTAERLDHEAQDKHILNIMV---RDQEFPYRRNLARVIVNVEDANDHS 1563
F ++P +G L+ LD EAQ+ +IL +M E + A V V++ + N+HS
Sbjct: 1044 -PFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHS 1102
Query: 1564 PYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEA-GNTGNMFKIEPVLGI 1622
P + +V E+ G++V +V A D+D G N L Y+++ F+I P G
Sbjct: 1103 PRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGE 1162
Query: 1623 ITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQA---- 1678
+T + D + L ++V D GSPP S T V ++V +++ P F+ A
Sbjct: 1163 VTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGL 1222
Query: 1679 --EVNENVDIGTSVILISAIS-----QSTLIYEVKDGDINGIFTINPYSGVITTQKALDY 1731
+V + V GT V + A T++Y + G + +F+++P+SG + T L
Sbjct: 1223 PIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAAPLIR 1281
Query: 1732 ERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSL 1791
Y L + A + +A++ + + P ++ L+E P +
Sbjct: 1282 AERPHYVLTLSAHDQGSPPRSASLQLLV----QVLPSARLAEPPPDLAERDPAAPV---- 1333
Query: 1792 DNSPLVIRATDADSNRNALLVYQIVE----------------STAKKFFTVDSSTGAIRT 1835
P+V+ T A+ R L+ + + + F +D+++G +
Sbjct: 1334 ---PVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYL 1390
Query: 1836 IANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLP 1895
LD E + + VR G P + V ++V D N++ P F + L
Sbjct: 1391 ARPLDFEAGPPWRA-LTVRAEG-PGGAGARLLRVQVQVQDENEHAPAFARDPLALALPEN 1448
Query: 1896 TYVGVEVLKVSATDPDSEVP-PELTYSLM--EGSLDHFLIDSNSGVLTIKN--NNLSKDH 1950
G + A+D D P ++ Y L+ E + +D+ +G L+ + +
Sbjct: 1449 PEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPA 1508
Query: 1951 YMLIVKVSDGKFYSTSM------VTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIV 2004
+L+V+ +D ++ + V + D+ F S + E+ V
Sbjct: 1509 LLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFA-SPSRVRLPEDQPPGPAALHV 1567
Query: 2005 NAVGNRLNEPLK--YSILNPGN-KFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELD 2061
A L E + Y + + G+ F++ S++G + P DRE++ + L V AS
Sbjct: 1568 VARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVR-PLDREQRAEHVLTVVASDHGS 1626
Query: 2062 HLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY 2121
R A V+ V++ D+ND +P F Y ++ + PGT + + A D D G NG+VTY
Sbjct: 1627 PPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY 1686
Query: 2122 VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIV-- 2179
F ++P++G + A + + E +T+ A+D G P T V + + +
Sbjct: 1687 GGVSSES-FSLDPDTGVLTTLRALDREEQE-EINLTVYAQDRGSPPQLTHVTVRVAVEDE 1744
Query: 2180 NKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE----GQGIIYIIIDGDPFKQFNIDF 2235
N P F + V E T + + A+ P+ GQ + Y I+DGDP F +D
Sbjct: 1745 NDHAPTFGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQ-LQYRILDGDPSGAFVLDL 1802
Query: 2236 DTGVLKVVSPLDYEVTSAYKLTIRASDALTGA-RAEVTVDLLVNDVNDNPPIFDQPTYNT 2294
+G + PLD EV A++L I A D A A + + + V D ND+ P F P Y+
Sbjct: 1803 ASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSV 1862
Query: 2295 TLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDH 2354
+ E GT +LQ+ + D D+ N V Y + T + F ++ SSG + TA LD
Sbjct: 1863 EVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGA---FLLEPSSGELRTAAALDR 1919
Query: 2355 ELVQHCTLKVRSIDSGFPS-LSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFV 2413
E T V ++D LS+ V V I + DVND+ P F + P
Sbjct: 1920 EQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTP 1979
Query: 2414 TC----VQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQ---RMEPLYS 2466
T ++A D D+ + Y L+G +DS +G I ++ R L+
Sbjct: 1980 TLALATLRAEDRDAGANASILYR-LAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFI 2038
Query: 2467 LNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPG 2526
+ + ++T + + + G P F +++ A +REN GT ++ RA G
Sbjct: 2039 VATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-G 2097
Query: 2527 TYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRAL---DGGGRTTF 2583
T G I+Y+I++ K F I + IT + L+ +VS +R + + GG F
Sbjct: 2098 TNGPITYSILSGNEKGTFSIQPSTGAITVRSAEG---LDFEVSPRLRLVLQAESGGAFAF 2154
Query: 2584 CTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEA 2643
+ + + D NDNAP+F+ Y A + + QV+A D D G+ +I+YSL A
Sbjct: 2155 TVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSL--AA 2212
Query: 2644 SVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPET 2703
S L +DP G + T ++ + A D G P + + V+
Sbjct: 2213 SQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTND 2272
Query: 2704 FLPSFTQSQYSFTIAEDTAIGSTVD--TLRILPSQNVWFSTVNGERPENNKGGIFVIEQE 2761
P+ Q + ++ED +GS + T + S V + ++ P++ F + +
Sbjct: 2273 NRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDP----FSVGRY 2327
Query: 2762 TGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDT 2821
G + L LD E + ++ A + TV V+ D+NDN P F S Y
Sbjct: 2328 GGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVE----DVNDNAPAFSQSLYQV 2383
Query: 2822 IIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKD- 2880
+++E P G+ + V A D D GANG ++Y L S + + F++D N G + T+
Sbjct: 2384 MLLEHTPPGSAILSVSATDRDSGANGHISYHLASPA------DGFSVDPNNGTLFTIVGT 2437
Query: 2881 --LDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDP 2938
L H+ + A D G A ++ A V V++ D ND+AP F YR V E P
Sbjct: 2438 VALGHDGSGAVDVVLEARDHG-APGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLP 2496
Query: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGN--------PR----------GRFALGLVQS 2980
PG + L D D S + V Y I GN PR G ALG +
Sbjct: 2497 PGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCL-- 2554
Query: 2981 EWKVYVKRPLDREEQDIYFLNITATDGLFVTQAMV---EVSVSDVNDNSPVCDQVAYTAL 3037
+ PLD E Y L + A D Q+ V V+V DVNDN PV + +Y
Sbjct: 2555 ----VLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVT 2610
Query: 3038 LPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLALLDRERI 3096
+PED P +L V A DAD G +G +R+++ S F LD SG L+ LD E
Sbjct: 2611 VPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQ 2670
Query: 3097 PVYSLMAKATD-GGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQA 3155
+ L+ +A D G F + + + ++DVND+ P F + +T V EN L+T + A
Sbjct: 2671 ARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHA 2730
Query: 3156 VDPDIGINRKVVYSLADSAGG-----VFSIDSSSGIIILEQPLDREQQSSYNISVRATDQ 3210
+D D G ++ YSL ++ G F+++SS+G + P D E S+ + V A D
Sbjct: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
Query: 3211 SPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAE 3270
+LS+ TV++ V ++ PVF + VPE G + V AT +D G +
Sbjct: 2791 G---NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGL 2847
Query: 3271 ITYLIRSGNEQGKFKINPKTGGI 3293
+ Y + + + F IN TG +
Sbjct: 2848 VLYSLATSSPY--FGINQTTGAL 2868
Score = 731 bits (1886), Expect = 0.0
Identities = 730/2686 (27%), Positives = 1192/2686 (44%), Gaps = 195/2686 (7%)
Query: 1052 VKENSRIGTSVLQVTARDEDSGRDGEIQY--SIRDGSGLGR-FSIDDESGVITAADILDR 1108
+ E GT + ++A +G + Y S ++GSG+G +ID+ SGV+ A +LDR
Sbjct: 51 IDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDR 109
Query: 1109 ETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
E Y T V P +T+EV + V D+ND+AP + V E++
Sbjct: 110 EQRDRYRFTA------VTPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYP 163
Query: 1169 QIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITT------TSRKLDREQQAEHFL 1222
A D D+ Y ++ F + + G T + +LDRE ++ + L
Sbjct: 164 LEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYML 223
Query: 1223 EVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFD 1282
++ DGG P+++ + V +LD ND+ P F + Y + E G P+ + FA D
Sbjct: 224 QLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSES--LAPGSPVLQVFASD 281
Query: 1283 RDEGPNAEISYSIV--DGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRPQ 1338
D G N ++Y I DG F ID TG++ + F L ++A D G
Sbjct: 282 ADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHP 341
Query: 1339 KSSTA--RLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPAN----TP 1392
+ +A +H+ PS + + F + V E+ ++V +SV +
Sbjct: 342 ELGSAFVTVHVRDANDNQPS-MTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAH 400
Query: 1393 LWFDIVGGNFDSAFDAEKGVGTIV-IAKPLDAEQRSIYNMSVEVTDGTNV---AVTQVFI 1448
+ + GG A + V +V +A+ LD E+R YN+ V TD + A +
Sbjct: 401 VNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVL 460
Query: 1449 KVLDNNDNGPEFSQPNY-DVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMR 1507
V D NDN P F + Y + E LP + ++++ A D D+ T +S
Sbjct: 461 HVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVT-YSLAPGAHTH 519
Query: 1508 KFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFT 1567
F IDP++G++ TA LD+E + + L ++ D P + A V V ++D ND+ P F
Sbjct: 520 WFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQ 579
Query: 1568 NPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAG--NTGNM-FKIEPVLGIIT 1624
Y AS+ E G+ LQVTA D D G L Y++ AG ++G+ F+I+ G +
Sbjct: 580 RTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVC 639
Query: 1625 ICKEPDMTT-MGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNEN 1683
+ D F ++ D G + + V++ ++ +++ P+F ++Y A ++
Sbjct: 640 TTRTLDRDQGPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYAASISAQ 697
Query: 1684 VDIGTSVILISAI-----SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQ 1738
GT+V+ + A S L Y + G+ +FT++ SG++T L S Q
Sbjct: 698 SPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQ 757
Query: 1739 LIIQATNMAGMAS--NATVNIQIVDENDNAPVFLFSQYSGSLSE-AAPINSI-VRSLDNS 1794
L I A + G+ + +A V+I IV P+F QY S+ E AP S+ + N
Sbjct: 758 LEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNP 817
Query: 1795 PLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVR 1854
P R A + + + F++D+ +G ++T+ LD E + + VR
Sbjct: 818 P----------GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPV-LELEVR 866
Query: 1855 DSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLP-TYVGVEVLKVSATDPDSE 1913
+GS A + V + + DVNDN P F A +T+LL P T G + + A DPDS
Sbjct: 867 -AGSGVPPAFAVARVRVLLDDVNDNSPAFP-APEDTVLLPPNTAPGTPIYTLRALDPDSG 924
Query: 1914 VPPELTYSLMEGSLDHFLIDSNSGVLTIKNN---NLSKDHYMLIVKVSDGKFYSTS--MV 1968
V +T++L+ G F +D +G + + + H + + G TS +
Sbjct: 925 VNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRL 984
Query: 1969 TIMVKEAMDSGL--HFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPG--N 2024
++V++ GL F Y + T T+V V A P+ Y + G +
Sbjct: 985 RVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYHLAAEGASS 1043
Query: 2025 KFKIKSTSGVIQTTGVPFDREEQELYELVVEA----SRELDHLRVARVVVRVNIEDINDN 2080
F ++ SG + DRE QELY L V A EL + VRV+I + N++
Sbjct: 1044 PFGLEPQSGWLWVRAA-LDREAQELYILKVMAVSGSKAELGQ-QTGTATVRVSILNQNEH 1101
Query: 2081 SPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQ---DDYGHFEINPNSG 2137
SP P + AV + PGT + +V A D+D GPNG +TY LQ +D F I+P +G
Sbjct: 1102 SPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTG 1161
Query: 2138 NVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTS--VELPITIVNKAMPVFDKPFYTAS- 2194
V + + + + Y + + +DGG P ST+ V + + +N P F + A
Sbjct: 1162 EVTTLQTLDREQQS-SYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGG 1220
Query: 2195 -----VNEDIRMNTPILSINATSP-EGQ-GIIYIIIDGDPFKQFNIDFDTGVLKVVSPLD 2247
V + + T + ++ A P EG+ G I + G + F++ +G L +PL
Sbjct: 1221 GLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLI 1280
Query: 2248 YEVTSAYKLTIRASDALTGARAEVTVDLLVN------------DVNDNPPIFDQPTYNTT 2295
Y LT+ A D + R+ ++ LLV D+ + P P T
Sbjct: 1281 RAERPHYVLTLSAHDQGSPPRS-ASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTV 1339
Query: 2296 LSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHE 2355
+ L +L V+ + + + + T F +D++SG + AR LD E
Sbjct: 1340 TAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGT--FALDAASGRLYLARPLDFE 1397
Query: 2356 LVQHC-TLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVT 2414
L VR+ G + + V + + D N++ P F + + E G +
Sbjct: 1398 AGPPWRALTVRAEGPGGAG-ARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALY 1456
Query: 2415 CVQASDADSSDFDR-LEYSILSGNDRTSFL-MDSKSGVITLSNHRKQRMEPLYSLNVSVS 2472
+ASDAD + + Y +L L +D+++G ++ + P L V +
Sbjct: 1457 TFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEAT 1516
Query: 2473 DGLFTST----AQVHIRVL--GANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPG 2526
D ++ A+V RV N +P F+ + V + E+ G +HV A D D G
Sbjct: 1517 DRPANASRRRAARVSARVFVTDENDNAPVFASPSRV-RLPEDQPPGPAALHVVARDPDLG 1575
Query: 2527 TYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTV 2586
++SY + + L S G + LDRE E +++ R+ +
Sbjct: 1576 EAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVL 1635
Query: 2587 RVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVS 2646
V V D ND AP F EY +R + G + ++A DPD GAN ++TY S S S
Sbjct: 1636 TVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFS 1695
Query: 2647 VADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLP 2706
+DPD G + T ++ + ++ V A D G P + + + V + V P
Sbjct: 1696 ------LDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAP 1749
Query: 2707 SFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERP----ENNKGGIFVIEQET 2762
+F + S + E G TL +L + + NG+ + + G FV++ +
Sbjct: 1750 TFGSAHLSLEVPE----GQDPQTLTMLRASDPDVGA-NGQLQYRILDGDPSGAFVLDLAS 1804
Query: 2763 GTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTI 2822
G + LDRE PAF ++ A + + T+ + + VLD ND+ P F +Y
Sbjct: 1805 GEFGTMRPLDREVEPAFQLRIEARDG-GQPALSATLLLTVTVLDANDHAPAFPVPAYSVE 1863
Query: 2823 IMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLD 2882
+ E +P GT L Q++A D D GANG VTY L + + AF ++ ++G + T LD
Sbjct: 1864 VPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAG-----AFLLEPSSGELRTAAALD 1918
Query: 2883 HETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDP---- 2938
E P++TFSV A D A LS+T V++ V D+ND+AP F R + P
Sbjct: 1919 REQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFST 1978
Query: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFA---LGLVQSEWKVYVKRPLDREEQ 2995
P +A L DRD N + Y + G P G G ++ P DR
Sbjct: 1979 PTLALATLRAEDRDAG-ANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDR--- 2034
Query: 2996 DIYFLNITATD-GLFVTQA--MVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVS 3052
L I ATD G A ++ V + + P + + A + E+ P I+
Sbjct: 2035 ---VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPR 2091
Query: 3053 AKDADIGSNGYIRYS-LYGSGNSEFFLDPESGELKTLAL--LDRERIPVYSLMAKATDGG 3109
A A G+NG I YS L G+ F + P +G + + LD E P L+ +A + G
Sbjct: 2092 AVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQA-ESG 2149
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYS 3169
G F + + L L+D NDN P F HY + E+ + L +V+A D D G ++ YS
Sbjct: 2150 GAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYS 2209
Query: 3170 LADS--AGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVL 3227
LA S A G+F +D ++G I LDRE + + + ATD+ +L T+T+ V+
Sbjct: 2210 LAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRG-SPALVGSATLTVMVI 2268
Query: 3228 DINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKIN 3287
D NDN P + + + V ED G+++ V T D+ + + Y++ Q F +
Sbjct: 2269 DTNDNRPTIPQ-PWELRVSEDALLGSEIAQV--TGNDVDSGPVLWYVLSPSGPQDPFSVG 2325
Query: 3288 PKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYS 3347
G +S++ LD+E C R+ L + A DG A + + + DVNDN P FSQ +Y
Sbjct: 2326 RYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGR---ANLTVLVEDVNDNAPAFSQSLYQ 2382
Query: 3348 AVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP---VLGLVKVKKKL 3404
++ E G +++ + A D DS NG I + + + + F+VDP L + L
Sbjct: 2383 VMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPA--DGFSVDPNNGTLFTIVGTVAL 2440
Query: 3405 DRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTS 3464
+ ++++A D G P ++ ATV++ + D ND++P FT ++Y + E+ P G++
Sbjct: 2441 GHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGST 2500
Query: 3465 ILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH---------------GILRSAVVF 3509
+L L TD D + +SI+SGN F L+P G L
Sbjct: 2501 LLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPL 2560
Query: 3510 QHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGV 3569
+Y L V A D G+P Q S + V V++ + + P + ED G
Sbjct: 2561 DFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAE 2620
Query: 3570 IGKIHATDQD--MYDVLTFALKS-EQKSLFKVNSHDGKIIALGGLD 3612
+ + A+D D + ++ F + S + LF+++ G + LD
Sbjct: 2621 LLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALD 2666
Score = 724 bits (1868), Expect = 0.0
Identities = 777/2937 (26%), Positives = 1245/2937 (42%), Gaps = 243/2937 (8%)
Query: 382 DVSISEFSPPGVVVAIVKL---SPEPIDVEYKLSPGEDA---VYFKINPRSGLIVTARPL 435
D+ I E P G ++ + + + Y +S E + I+ SG++ TAR L
Sbjct: 48 DLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVL 107
Query: 436 NTVKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVS 495
+ +++ Y+ +G +VT+ + D NDH P F Q V E GT
Sbjct: 108 DREQRDRYRFTAVTPDG-ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEP 166
Query: 496 ASDKDKGENGYITYSIAS--------LNLLPFVINQFTGVISTTEELDFESSPEIYRFIV 547
A D D G G Y+++ L P + T ELD E+ Y +
Sbjct: 167 ARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSH-YMLQL 225
Query: 548 RASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE 607
A D GSP R ++ + + + ++ND++P F + V+S G + V A D D
Sbjct: 226 EAYDGGSPPRR-AQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADA 284
Query: 608 --LELVKYKIISGNELGF--FYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLAD 663
V Y+I G F ++ +G+LQL++ L + L + A DG
Sbjct: 285 GVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFE--QRRVHELVVQARDGG---- 338
Query: 664 PMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGP 723
H ++ S + +I A+G
Sbjct: 339 --------AHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQ---------------- 374
Query: 724 YFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNI-DMETGQ 782
V E P G + +I D D G V ++ G + D
Sbjct: 375 -----------VSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYL 423
Query: 783 LKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILE 842
+ V +DRE D Y L +T D G+P + ++V D NDN+P F + Y L
Sbjct: 424 VCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLP 483
Query: 843 SSGI-GTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKAN 899
+ G+ +++V ARD D G+NG+VTYS+ T F+I+ ++GI+ A LD E +
Sbjct: 484 EVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQ 543
Query: 900 YSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLE 959
L + A D L S T+ V L DVND P F + Y+ + E GT +
Sbjct: 544 PQLIVVATDGGLP--PLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVT 601
Query: 960 THDPDLGLGGQVRYSLVNDYNGR----FEIDKASGAIRLSKELDYEK-QQFYNLTVRAKD 1014
D D G G + YSL F ID SG + ++ LD ++ ++ TV A D
Sbjct: 602 ATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVD 661
Query: 1015 KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGR 1074
G L S+ +V+V + D N+N P F S+ S GT+VL++ A D D G
Sbjct: 662 GG---GLKSMVYVKVFLSDENDN--PPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGS 716
Query: 1075 DGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEV 1134
G + Y I G+ F++D++SG++T A L R L + A D G + + V
Sbjct: 717 HGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARV 776
Query: 1135 YIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQN 1194
I + P+ + Y V E+ SV +QA +P +T ++ G+P+
Sbjct: 777 DISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRL-APVTLSLSGGDPRG 835
Query: 1195 FFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDE-NDNKPQ 1253
F+++ +GL+ T R LDRE LE+ V G P + V +LD+ NDN P
Sbjct: 836 LFSLDAVSGLLQTL-RPLDRELLGP-VLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPA 893
Query: 1254 FPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMV 1313
FP + LP G PIY A D D G N+ ++++++ G G F +DP TG V
Sbjct: 894 FPAPEDTVLLPPNTAP--GTPIYTLRALDPDSGVNSRVTFTLLAGGG-GAFTVDPTTGHV 950
Query: 1314 SSRKQF--TAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTV 1371
+ + G L ++A D G P ++S RL + ++ + F+ P Y +
Sbjct: 951 RLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVV-VQDVGTRGLAPRFNSPTYRVDL 1009
Query: 1372 MESDRV-TEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYN 1430
T+++ V + P P+ + + S F E G + + LD E + +Y
Sbjct: 1010 PSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYI 1069
Query: 1431 MSVEVTDGTNVAVTQ------VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEA 1484
+ V G+ + Q V + +L+ N++ P S+ + ++E+ P T + ++ A
Sbjct: 1070 LKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFA 1129
Query: 1485 TDRDE--KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1542
TDRD +L+Y++ S + FRI P TG + T + LD E Q + L + V+D
Sbjct: 1130 TDRDSGPNGRLTYSLQQL--SEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGG 1187
Query: 1543 FPYRRNLARVIVNVEDANDHSPYFTNPLYEAS------VFESAALGSAVLQVTALDKDKG 1596
P R V V V D ND+SP F A V + G+ V + A D D+G
Sbjct: 1188 SPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEG 1247
Query: 1597 ENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAI 1656
EN ++YT+ G +F + P G + +VL++ DQGSPP SA+
Sbjct: 1248 ENGTILYTL-TGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQ 1306
Query: 1657 VRISVTMSDN---SHPKFIHKDYQAEVN--------ENVDIGT---SVILISAISQSTLI 1702
+ + V S P +D A V E + G+ SV L
Sbjct: 1307 LLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALT 1366
Query: 1703 YEVKDG-DINGIFTINPYSGVITTQKALDYERTSSYQ-LIIQATNMAGMASNAT-VNIQI 1759
Y + G D G F ++ SG + + LD+E ++ L ++A G + V +Q+
Sbjct: 1367 YTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQV 1426
Query: 1760 VDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADS-NRNALLVYQIV-E 1817
DEN++AP F + +L E + + + RA+DAD N+ + Y+++ +
Sbjct: 1427 QDENEHAPAFARDPLALALPENPEPGAALYTF-------RASDADGPGPNSDVRYRLLRQ 1479
Query: 1818 STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDS-GSPQLTAESPVEVNIEVTDV 1876
+D+ TGA+ LD ET V D + + V + VTD
Sbjct: 1480 EPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDE 1539
Query: 1877 NDNPPVFTQAVFETILLLPTYV--GVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDS 1934
NDN PVF + + LP G L V A DPD ++Y L G HF + S
Sbjct: 1540 NDNAPVFASP---SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHS 1596
Query: 1935 NSGVLTIK---NNNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLHFTQSFYST 1989
++G L++ + +H + +V G +T ++T+ V + D F Q YS
Sbjct: 1597 STGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSV 1656
Query: 1990 SISENNTNITKVAIVNAVGNRL--NEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQ 2047
+ ENN T + + A + N + Y ++ F + +GV+ TT DREEQ
Sbjct: 1657 LLRENNPPGTSLLTLRATDPDVGANGQVTYGGVS-SESFSLDPDTGVL-TTLRALDREEQ 1714
Query: 2048 ELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVT 2107
E L V A ++ V VRV +ED ND++P F V +P TL +
Sbjct: 1715 EEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLT-MLR 1773
Query: 2108 AIDKDKGPNGEVTYVLQDD--YGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGK 2165
A D D G NG++ Y + D G F ++ SG + ++ + + I A+DGG+
Sbjct: 1774 ASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPA-FQLRIEARDGGQ 1832
Query: 2166 PSLSTSVELPITIV--NKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEG--QGIIYI 2221
P+LS ++ L +T++ N P F P Y+ V ED+ T +L + A P+ G +
Sbjct: 1833 PALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY 1892
Query: 2222 IIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVD--LLVND 2279
+ F ++ +G L+ + LD E +Y ++ A D TV + V D
Sbjct: 1893 YLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRD 1952
Query: 2280 VNDNPPIFDQPTYNTTLSEAS-LIGTPVLQVVSI---DADSENNKMVHYQIVQDTYNSTD 2335
VND+ P F L TP L + ++ D D+ N + Y++ T
Sbjct: 1953 VNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTT 2012
Query: 2336 YFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFN 2395
+DS +G I AR + L + + D G P+ S+ ++ + + + P F
Sbjct: 2013 ---VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFP 2069
Query: 2396 QLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSN 2455
+ E+ + E AP G + +A A ++ + YSILSGN++ +F + +G IT+ +
Sbjct: 2070 RASSEATIRENAPPGTPIVSPRAVHAGGTN-GPITYSILSGNEKGTFSIQPSTGAITVRS 2128
Query: 2456 HRKQRMEPLYSLNVSV---SDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG 2512
E L + + S G F T + + + AN +P F + YVA + E+
Sbjct: 2129 AEGLDFEVSPRLRLVLQAESGGAFAFTV-LTLTLQDANDNAPRFLRPHYVAFLPESRPLE 2187
Query: 2513 TKVIHVRATDGDPGTYGQISYAII-NDFAKDRFLID-SNGQVITTERLDRENPLEGDVSI 2570
++ V A D D G+ GQISY++ + A+ F +D + G + TT LDRE + + +
Sbjct: 2188 GPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDRE--IWAETRL 2245
Query: 2571 FVRALDGGGRTTF--CTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPD 2628
+ A D G T+ V+V+D NDN P + + V D G + QV D D
Sbjct: 2246 VLMATDRGSPALVGSATLTVMVIDTNDNRPT-IPQPWELRVSEDALLGSEIAQVTGNDVD 2304
Query: 2629 DGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKG--NFNQLKNTVLSFFVKAVDGGIP 2686
G + + + S + D + G + G +F Q L A DG
Sbjct: 2305 SGP---VLWYVLSPSGPQ--DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLL--AHDGPHE 2357
Query: 2687 VKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNV-------- 2738
+ +L + V P+F+QS Y + E T GS + ++ +
Sbjct: 2358 GRANLTVLVEDV---NDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYH 2414
Query: 2739 WFSTVNGERPENNKGGIFVIEQETGTIKL--------DKRLDRETSPAFHFKVAATIPLD 2790
S +G + N G +F I GT+ L D L+ A AT
Sbjct: 2415 LASPADGFSVDPNNGTLFTI---VGTVALGHDGSGAVDVVLEARDHGAPGRAARAT---- 2467
Query: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWG-ANGQV 2849
V +++ D ND+ P F S Y + E +P G+ L + A D D ++ V
Sbjct: 2468 ---------VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAV 2518
Query: 2850 TYSLHSDS-------QPEKVMEAFNIDSNT---GWISTLKDLDHETDPTFTFSVVASDLG 2899
YS+ S + +P + G + L+ LD E+ + +V A+D G
Sbjct: 2519 DYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRG 2578
Query: 2900 EAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQ 2959
+ SS V+V V D+NDN PVF + YR V E P G + + D D +
Sbjct: 2579 QP-PQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGP-HGL 2636
Query: 2960 VSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATD--GLFVTQAMVEV 3017
V + ++ G+P G F L +S + + LD E Q + L + A D G A V +
Sbjct: 2637 VRFTVSSGDPSGLFELD--ESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTI 2694
Query: 3018 SVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSG----- 3072
V DVND+ P + + E+ P ++ + A D D G+ G +RYSL +G
Sbjct: 2695 EVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEG 2754
Query: 3073 NSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFS 3132
F L+ +GEL+ D E + L+ A D G + +++ ++ PVF
Sbjct: 2755 REAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFL 2814
Query: 3133 SDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIIL 3189
+ ++ V E L VQA D D G + V+YSLA S+ F I+ ++G + L
Sbjct: 2815 APAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS-PYFGINQTTGALYL 2870
Score = 721 bits (1860), Expect = 0.0
Identities = 751/2894 (25%), Positives = 1251/2894 (43%), Gaps = 269/2894 (9%)
Query: 116 ILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
+L+RE +D Y +V + A +V ++V D+ND P F ++ + E T T
Sbjct: 106 VLDREQRDRYRFT---AVTPDG--ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGT 160
Query: 176 SVAQVTATDADIGSNGEFYYYFKNKV--DLFSVHPTSGV-------ISLSGRLNYDEKNR 226
A DAD G G Y + F + G + ++G L+ + ++
Sbjct: 161 RYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSH 220
Query: 227 YDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTH---VPFSLEKEPTYA 283
Y L++ A D G + + A L V + IN+HAP + + V SL
Sbjct: 221 YMLQLEAYDGG-----SPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
Query: 284 VVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNL 343
V D D G NG + D F L ++ + +D+E + L
Sbjct: 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGL----LQLERPLDFEQRRV-HEL 330
Query: 344 TLQAKDKGS-PQKCSALKAVYI--GNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKL 400
+QA+D G+ P+ SA V++ N + ++ + F +SE +PPG +VA + +
Sbjct: 331 VVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISV 390
Query: 401 SPEPID-----VEYKLSPGEDAVYFKINPRSG---LIVTARPLNTVKKEVYKLEVTNKEG 452
S +P D V L GE +F ++ + L+ AR L+ +++ Y L VT +
Sbjct: 391 S-DPDDGDFAHVNVSLEGGEG--HFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDS 447
Query: 453 D-----LKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-GTSVLTVSASDKDKGENGY 506
+A + + D ND+ P F + LY V + G+ V+ V+A D D+G NG
Sbjct: 448 GSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQ 507
Query: 507 ITYSIA-SLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+TYS+A + F I+ +G+I+T LD+E P+ + IV A+D G P S V+
Sbjct: 508 VTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQP-QLIVVATDGGLPPL-ASSATVS 565
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELGF 623
+ + +VNDN P F++ + G V+A D D L+ Y + +G LG
Sbjct: 566 VALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAG--LGS 623
Query: 624 -----FYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSS 678
F ++ SG + ++L + +F +TA DG L + + +
Sbjct: 624 SGSPPFRIDAHSGDVCTTRTLDRDQGPS-SFDFTVTAVDGGGLKSMVYVKV--------- 673
Query: 679 KSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGP--YFDKSFPSDVAVK 736
F S P ++ + + + ++ +
Sbjct: 674 ------------------------------------FLSDENDNPPQFYPREYAASISAQ 697
Query: 737 EDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDL 796
P G +L+++A+D D G +G++ + I GN+ F +D ++G L V P+ R +
Sbjct: 698 S--PPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSV 755
Query: 797 YLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEAR 856
L I D G Q + I++ P+F Q Y ++ E GT + V+A
Sbjct: 756 VQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAH 815
Query: 857 DKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG- 913
+ G VT S+ + F++++ +G++ LDRE L++E R A SG
Sbjct: 816 NPP-GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPV-LELEVR--AGSGV 871
Query: 914 QQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRY 973
F+V ++V LDDVND SPAF +V + + GT I L DPD G+ +V +
Sbjct: 872 PPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTF 931
Query: 974 SLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVD 1033
+L+ G F +D +G +RL + L + L + A+D G P S + V V D
Sbjct: 932 TLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFR-LRVVVQD 990
Query: 1034 VNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSI 1093
V P F + + GT VLQV A+ D G I Y + F +
Sbjct: 991 VGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PITYHLAAEGASSPFGL 1047
Query: 1094 DDESGVITAADILDRETMGSYWLTVYATDRGVVPL---YSTIEVYIEVEDVNDNAPLTSE 1150
+ +SG + LDRE Y L V A L T V + + + N+++P SE
Sbjct: 1048 EPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSE 1107
Query: 1151 PIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITS-GNPQNFFAINIKTGLITTTS 1209
+ V EN P SV ++ A D DS N +LTY + F I+ +TG +TT
Sbjct: 1108 DPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTL- 1166
Query: 1210 RKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKV------YQIKL 1263
+ LDREQQ+ + L V V DGG P+ +T V V VLD NDN P F + I++
Sbjct: 1167 QTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQV 1226
Query: 1264 PERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGS 1323
P DR G + A D DEG N I Y++ G F + P +G + +
Sbjct: 1227 P--DRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLTAAPLIRAE 1283
Query: 1324 --YDILTIKAVDNGRPQKSSTARLHIEWIK-----KPPP--------SPIPLTFDEPFYN 1368
+ +LT+ A D G P +S++ +L ++ + +PPP +P+P+
Sbjct: 1284 RPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVL-----T 1338
Query: 1369 FTVMESDRVTEIVGVVSV-QPANT-PLWFDIVGG-NFDSAFDAEKGVGTIVIAKPLDAEQ 1425
T E R ++G V+ +PA L + +VGG + + F + G + +A+PLD E
Sbjct: 1339 VTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEA 1398
Query: 1426 RSIYN---MSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQI 1482
+ + E G + +V ++V D N++ P F++ + + E+ P +
Sbjct: 1399 GPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTF 1458
Query: 1483 EATDRDEKHKLSYTVHSSI-DSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 1541
A+D D S + + + R+D TG L LD E +L + D+
Sbjct: 1459 RASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDR 1518
Query: 1542 EF-PYRRNLARVI--VNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGEN 1598
RR ARV V V D ND++P F +P + E G A L V A D D GE
Sbjct: 1519 PANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEA 1577
Query: 1599 AELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVR 1658
A + Y + +G G+ F++ G +++ + D + VL++ +D GSPP SAT ++
Sbjct: 1578 ARVSYRLASGGDGH-FRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLT 1636
Query: 1659 ISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQSTLIY-EVKDGDING-IFTI 1716
+SV ++ P F ++Y + EN GTS++ + A +V G ++ F++
Sbjct: 1637 VSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSL 1696
Query: 1717 NPYSGVITTQKALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY 1774
+P +GV+TT +ALD E L + A + ++ TV + + DEND+AP F +
Sbjct: 1697 DPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHL 1756
Query: 1775 SGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIR 1834
S + E ++ ++RA+D D N L Y+I++ F +D ++G
Sbjct: 1757 SLEVPEGQDPQTLT--------MLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFG 1808
Query: 1835 TIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLL 1894
T+ LD E F + RD G P L+A + + + V D ND+ P F + +
Sbjct: 1809 TMRPLDREVEPAFQLRIEARDGGQPALSAT--LLLTVTVLDANDHAPAFPVPAYSVEVPE 1866
Query: 1895 PTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDH---Y 1951
G +L++ A DPD+ +TY L G+ FL++ +SG L L ++ Y
Sbjct: 1867 DVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAA-LDREQCPSY 1925
Query: 1952 MLIVKVSDGK----FYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAV 2007
V DG +T VTI V++ D F S + + + + A
Sbjct: 1926 TFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALAT 1985
Query: 2008 GNR------LNEPLKYSILN-PGNKFKIKSTSGVIQTTGVP--FDREEQELYELVVEASR 2058
N + Y + P + S +G I+ P ++ L+ + + R
Sbjct: 1986 LRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGR 2045
Query: 2059 ELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGE 2118
R A V+ V ++ + P F A ++ +A PGT I A+ G NG
Sbjct: 2046 PA---RSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGP 2101
Query: 2119 VTYVLQ--DDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPI 2176
+TY + ++ G F I P++G + ++ A D +L + G T + L +
Sbjct: 2102 ITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTL 2161
Query: 2177 TIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATS-PEGQG--IIYIIIDGDPFKQ-FN 2232
N P F +P Y A + E + P+L + A +G G I Y + P + F+
Sbjct: 2162 QDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFH 2221
Query: 2233 IDFDTGVLKVVSPLDYEVTSAYKLTIRASD----ALTGARAEVTVDLLVNDVNDNPPIFD 2288
+D TG + + LD E+ + +L + A+D AL G+ T+ ++V D NDN P
Sbjct: 2222 VDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGS---ATLTVMVIDTNDNRPTIP 2278
Query: 2289 QPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILT 2348
QP + +SE +L+G+ + QV D DS ++ Y V D F + G +
Sbjct: 2279 QP-WELRVSEDALLGSEIAQVTGNDVDS--GPVLWY--VLSPSGPQDPFSVGRYGGRVSL 2333
Query: 2349 ARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAP 2408
LD E L++ + D ++ + + + DVNDN P F+Q +Y+ + E P
Sbjct: 2334 TGPLDFEQCDRYQLQLLAHDGPHEGRAN---LTVLVEDVNDNAPAFSQSLYQVMLLEHTP 2390
Query: 2409 RGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGV-------ITLSNHRKQRM 2461
G + V A+D DS + Y + S D F +D +G + L + +
Sbjct: 2391 PGSAILSVSATDRDSGANGHISYHLASPAD--GFSVDPNNGTLFTIVGTVALGHDGSGAV 2448
Query: 2462 EPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRAT 2521
+ + + G + A VH+++ N ++P+F+ S Y V E++ G+ ++ + AT
Sbjct: 2449 DVVLEARDHGAPGR-AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT 2507
Query: 2522 DGDPG-TYGQISYAIIND-----FAKDRFLIDSN----------GQVITTERLDRENPLE 2565
D D ++ + Y+II+ F + L ++ G ++ E LD E+ +
Sbjct: 2508 DADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQ 2567
Query: 2566 GDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAI 2625
++++ +++ V V V+D NDN P F YR +V D G + V+A
Sbjct: 2568 YNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEAS 2627
Query: 2626 DPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGI 2685
D D G + + +++ +S + L E+D +G + + V+A D
Sbjct: 2628 DADPGPHGLVRFTV---SSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPA- 2683
Query: 2686 PVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVN- 2744
+L PV I V P+F + S ++AE+ G+ V TL + F +
Sbjct: 2684 GAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRY 2743
Query: 2745 -----GERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVD 2799
G PE + F + TG ++ D E + +F V A D ++ +V
Sbjct: 2744 SLLEAGPGPEGREA--FALNSSTGELRARVPFDYEHTESFRLLVGAA---DAGNLSASVT 2798
Query: 2800 VDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQP 2859
V + V ++ PVF ++ + EG G L V+A D D GA+G V YSL + S
Sbjct: 2799 VSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS-- 2856
Query: 2860 EKVMEAFNIDSNTG 2873
F I+ TG
Sbjct: 2857 ----PYFGINQTTG 2866
Score = 671 bits (1731), Expect = 0.0
Identities = 648/2424 (26%), Positives = 1076/2424 (44%), Gaps = 200/2424 (8%)
Query: 114 SAILNREIQDNYLLIVKGSVRG-EDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTP 172
+A L+ E++ LIV + G L + V++ + D+ND P F T Y+ ++ E T
Sbjct: 533 AASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQ 592
Query: 173 LRTSVAQVTATDADIGSNGEFYYYF-----KNKVDLFSVHPTSGVISLSGRLNYDE-KNR 226
T QVTATDAD G G Y + F + SG + + L+ D+ +
Sbjct: 593 PGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSS 652
Query: 227 YDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP-FSLEKEPTYAVV 285
+D + AVD G G+ S + V + N++ P + + S + P AV+
Sbjct: 653 FDFTVTAVDGG-------GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVL 705
Query: 286 TV--DDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNL 343
+ D D G++G + S I+AG+ F L ++ L R+ G
Sbjct: 706 RLRAHDPDQGSHGRL-SYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIG--- 761
Query: 344 TLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPE 403
A+D G Q + + P T PI FE+ Y S+ E PG V IV+
Sbjct: 762 ---AEDGGGLQAEPSARVDISIVPGTPTPPI-FEQLQYVFSVPEDVAPGTSVGIVQAHNP 817
Query: 404 P---IDVEYKLSPGEDAVYFKINPRSGLIVTARPLNT-VKKEVYKLEVTNKEGD----LK 455
P V LS G+ F ++ SGL+ T RPL+ + V +LEV G
Sbjct: 818 PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAV 877
Query: 456 AQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN 515
A+V + ++D ND++P F P + + GT + T+ A D D G N +T+++ +
Sbjct: 878 ARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG 937
Query: 516 LLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYR-HESEVNVTIRIGNVNDN 574
F ++ TG + L P + + A D GSP R + V ++
Sbjct: 938 GGAFTVDPTTGHVRLMRPLGPSGGP-AHELELEARDGGSPPRTSHFRLRVVVQDVGTRGL 996
Query: 575 SPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQ 634
+P F + + G + V A + + Y + + F L P SG L
Sbjct: 997 APRFNSPTYRVDLPSGTTAGTQVLQVQA-QAPDGGPITYHLAAEGASSPFGLEPQSGWLW 1055
Query: 635 LKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAE 694
++ +L + L++ A G
Sbjct: 1056 VRAALDREA--QELYILKVMAVSGS----------------------------------- 1078
Query: 695 KLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDAD 754
KA+ + + + N P + P+ +AV E+ P G ++ ++ A D D
Sbjct: 1079 ----KAELGQQTGTATVRVSILNQNEHSPRLSED-PTFLAVAENQPPGTSVGRVFATDRD 1133
Query: 755 SGFNGKVLFTISDGNTDS-CFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSS 813
SG NG++ +++ + DS F I +TG++ L +DRE Y L + + D G+P +S+
Sbjct: 1134 SGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRST 1193
Query: 814 WRLLTINVEDANDNSPVFIQDS------YSVNILESSGIGTEIIQVEARDKDLGSNGEVT 867
+ + V D NDNSP F+Q S + + + GT + ++A+D D G NG +
Sbjct: 1194 TGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTIL 1253
Query: 868 YSVL-TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARD-----KAESGQQLFSVVT 921
Y++ ++ F+++ +G + A L R + +Y L + A D ++ S Q L V+
Sbjct: 1254 YTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLP 1313
Query: 922 LKVFLD---DVNDCSPAF-IPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
+ D+ + PA +P +V E L G+++ + +P G+G + Y+LV
Sbjct: 1314 SARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEP-AGVGA-LTYTLVG 1371
Query: 978 --DYNGRFEIDKASGAIRLSKELDYEK-QQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDV 1034
D G F +D ASG + L++ LD+E + LTVRA+ G + + V+V
Sbjct: 1372 GADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGG----AGARLLRVQVQVQ 1427
Query: 1035 NENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDS-GRDGEIQYS-IRDGSGLGRFS 1092
+EN H P F + ++ EN G ++ A D D G + +++Y +R +
Sbjct: 1428 DENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALR 1487
Query: 1093 IDDESGVITAADILDRETMGSYWLTVYATDRGVVP---LYSTIEVYIEVEDVNDNAPLTS 1149
+D +G ++A LDRET + L V ATDR + + + V D NDNAP+ +
Sbjct: 1488 LDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFA 1547
Query: 1150 EPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS 1209
P + E+ P + + + A DPD +++YR+ SG F ++ TG ++
Sbjct: 1548 SPSRVR-LPEDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVV- 1604
Query: 1210 RKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRK 1269
R LDREQ+AEH L V +D G P+ +T + V V D ND P F ++ Y + L R+
Sbjct: 1605 RPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLL--RENN 1662
Query: 1270 KRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYD--IL 1327
G + A D D G N +++Y G F +DP TG++++ + + L
Sbjct: 1663 PPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALDREEQEEINL 1719
Query: 1328 TIKAVDNGRPQKSS--TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVS 1385
T+ A D G P + + T R+ +E P TF + V E + + +
Sbjct: 1720 TVYAQDRGSPPQLTHVTVRVAVEDENDHAP-----TFGSAHLSLEVPEGQDPQTLTMLRA 1774
Query: 1386 VQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVA 1442
P AN L + I+ G+ AF + G +PLD E + + +E DG A
Sbjct: 1775 SDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPA 1834
Query: 1443 VTQVF---IKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHS 1499
++ + VLD ND+ P F P Y V + EDV T +LQ++A D D T +
Sbjct: 1835 LSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYY- 1893
Query: 1500 SIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVIVNVE 1557
+ + + F ++PS+G L TA LD E + ++ D P ++ V + V
Sbjct: 1894 -LGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVS-VTITVR 1951
Query: 1558 DANDHSPYF-TNPL-----YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTG 1611
D NDH+P F T+PL F + L A L+ A D+D G NA ++Y + AG
Sbjct: 1952 DVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLR--AEDRDAGANASILYRL-AGTPP 2008
Query: 1612 NMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKF 1671
++ G I + + P VL I TD G P SAT ++ + + P+F
Sbjct: 2009 PGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRF 2068
Query: 1672 IHKDYQAEVNENVDIGTSVILISAI----SQSTLIYEVKDGDINGIFTINPYSGVITTQK 1727
+A + EN GT ++ A+ + + Y + G+ G F+I P +G IT +
Sbjct: 2069 PRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRS 2128
Query: 1728 A--LDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPIN 1785
A LD+E + +L++QA + G + + + + D NDNAP FL Y L E+ P
Sbjct: 2129 AEGLDFEVSPRLRLVLQAES-GGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRP-- 2185
Query: 1786 SIVRSLDNSPLVIRATDADSNRNALLVYQIVES-TAKKFFTVDSSTGAIRTIANLDHETI 1844
L+ L + A D D + Y + S A+ F VD +TG I T A LD E
Sbjct: 2186 -----LEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIW 2240
Query: 1845 AHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLK 1904
A + D GSP L + + + V D NDN P Q +E + +G E+ +
Sbjct: 2241 AETRLVLMATDRGSPALVGSA--TLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQ 2297
Query: 1905 VSATDPDSEVPPELTYSLM-EGSLDHFLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK 1961
V+ D DS P L Y L G D F + G +++ + D Y L + DG
Sbjct: 2298 VTGNDVDS--GPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGP 2355
Query: 1962 FYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAV--GNRLNEPLKYSI 2019
+ +T++V++ D+ F+QS Y + E+ + + V+A + N + Y +
Sbjct: 2356 HEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL 2415
Query: 2020 LNPGNKFKIKSTSGVIQTT--GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDI 2077
+P + F + +G + T V + ++V+EA R AR V V ++D
Sbjct: 2416 ASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQ 2475
Query: 2078 NDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKD-KGPNGEVTY-VLQDDYGH-FEINP 2134
ND++P F Y AV D PG+ + + A D D + V Y ++ ++G F++ P
Sbjct: 2476 NDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEP 2535
Query: 2135 N--------------SGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI-- 2178
G ++L E + + S +Y +T+ A D G+P S+ V + +T+
Sbjct: 2536 RLAEAGESAGPGPRALGCLVLLEPLDFE-SLTQYNLTVAAADRGQPPQSSVVPVTVTVLD 2594
Query: 2179 VNKAMPVFDKPFYTASVNEDIRMNTPILSINAT--SPEGQGII-YIIIDGDPFKQFNIDF 2235
VN PVF + Y +V ED + +L + A+ P G++ + + GDP F +D
Sbjct: 2595 VNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDE 2654
Query: 2236 DTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTT 2295
+G L++ LD E + ++L ++A+D A V + V DVND+ P F +T+
Sbjct: 2655 SSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTS 2714
Query: 2296 LSEASLIGTPVLQVVSIDADSENNKMVHYQIVQ--DTYNSTDYFHIDSSSGLILTARMLD 2353
++E GT V + +ID D+ + Y +++ + F ++SS+G + D
Sbjct: 2715 VAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFD 2774
Query: 2354 HELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFV 2413
+E + L V + D+G +LS+ V V + ++ ++ PVF + V E A RGH +
Sbjct: 2775 YEHTESFRLLVGAADAG--NLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSL 2832
Query: 2414 TCVQASDADSSDFDRLEYSILSGN 2437
VQA+D D + YS+ + +
Sbjct: 2833 GHVQATDEDGGADGLVLYSLATSS 2856
Score = 562 bits (1448), Expect = e-159
Identities = 582/2107 (27%), Positives = 931/2107 (44%), Gaps = 215/2107 (10%)
Query: 140 AWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYY-YFK 198
A +V + + D+ND P F +V + +T T + + A D D G N +
Sbjct: 876 AVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLA 935
Query: 199 NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIER 258
F+V PT+G + L L ++LE+ A D G + +S +L V ++
Sbjct: 936 GGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGG-----SPPRTSHFRLRVVVQD 990
Query: 259 INEH--APTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVA----GDPLDQF 312
+ AP + PTY V DL G + + + A G P+ +
Sbjct: 991 VGTRGLAPRFN-----------SPTYRV----DLPSGTTAGTQVLQVQAQAPDGGPIT-Y 1034
Query: 313 FLAKEGK-------------WLNEYKIKERKQIDWESFPYGYNLTLQA----KDKGSPQK 355
LA EG W+ +E +++ Y L + A K + Q
Sbjct: 1035 HLAAEGASSPFGLEPQSGWLWVRAALDREAQEL--------YILKVMAVSGSKAELGQQT 1086
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPG- 414
+A V I N + R ++ ++++E PPG V V + +L+
Sbjct: 1087 GTATVRVSILNQNEHSP--RLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL 1144
Query: 415 ----EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVT-----ISIEDA 465
ED+ F+I+P++G + T + L+ ++ Y+L V ++G + T +++ D
Sbjct: 1145 QQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDL 1204
Query: 466 NDHTPEFQQPLYDA------YVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPF 519
ND++P F Q A V + VP GT V T+ A D D+GENG I Y++ F
Sbjct: 1205 NDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELF 1264
Query: 520 VINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSP--- 576
++ +G + T L P Y + A D GSP R S + + + P
Sbjct: 1265 SLHPHSGELLTAAPLIRAERPH-YVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPD 1323
Query: 577 LFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLK 636
L E+ V PV +TA + G+ LG +GV L
Sbjct: 1324 LAERDPAAPV-----PVVLTVTAAEGLR------------PGSLLGSVAAPEPAGVGALT 1366
Query: 637 KSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKL 696
+L G FAL A+ LA P+ ++ + R A L
Sbjct: 1367 YTLVGGADPEGTFALD-AASGRLYLARPLDFEAGP-----PWRALTVRAEGPGGAGARLL 1420
Query: 697 LIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADS- 755
++ + + N P F + P +A+ E+ GA + +A DAD
Sbjct: 1421 RVQVQVQDE-------------NEHAPAFARD-PLALALPENPEPGAALYTFRASDADGP 1466
Query: 756 GFNGKVLFTISDGNTD-SCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSW 814
G N V + + +D TG L +DRE T LL + D P +S
Sbjct: 1467 GPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATD--RPANASR 1524
Query: 815 RLLT-----INVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYS 869
R + V D NDN+PVF S V + E G + V ARD DLG V+Y
Sbjct: 1525 RRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYR 1583
Query: 870 VLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ + F ++SSTG + V LDRE +A + L + A D + V+T+ V D
Sbjct: 1584 LASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVA--D 1641
Query: 929 VNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKA 988
VND +P F YSV + E+ P GT + L DPD+G GQV Y V+ + F +D
Sbjct: 1642 VNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES--FSLDPD 1699
Query: 989 SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV 1048
+G + + LD E+Q+ NLTV A+D+G P L+ V+ V V +EN H P F +
Sbjct: 1700 TGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVT---VRVAVEDENDHAPTFGSAHL 1756
Query: 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDR 1108
V E T + + A D D G +G++QY I DG G F +D SG LDR
Sbjct: 1757 SLEVPEGQDPQTLTM-LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDR 1815
Query: 1109 ETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
E ++ L + A D G L +T+ + + V D ND+AP P Y V E+ P ++
Sbjct: 1816 EVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLL 1875
Query: 1169 QIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTD 1228
Q+QA DPD+ +N +TY + +G F + +G + T + LDREQ + V+ D
Sbjct: 1876 QLQAHDPDAGANGHVTYYLGAGTA-GAFLLEPSSGELRTAAA-LDREQCPSYTFSVSAVD 1933
Query: 1229 GGPS-PKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAF--AFDRDE 1285
G + P +T+ V + V D ND+ P FP +++LP + A A DRD
Sbjct: 1934 GAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDA 1993
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVS-SRKQFTAGSYD-ILTIKAVDNGRPQKSSTA 1343
G NA I Y + G +D TG + +R G D +L I A D GRP +S+T
Sbjct: 1994 GANASILYRLAGTPPPGTT-VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATG 2052
Query: 1344 RLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV-TEIVGVVSVQPANT--PLWFDIVGG 1400
+ + + P F T+ E+ T IV +V T P+ + I+ G
Sbjct: 2053 VIIVGLQGEAERGP---RFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSG 2109
Query: 1401 NFDSAFDAEKGVGTIVI--AKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGP 1458
N F + G I + A+ LD E + ++ G A T + + + D NDN P
Sbjct: 2110 NEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAP 2169
Query: 1459 EFSQPNYDVTISEDVLPDTEILQIEATDRDEKH--KLSYTVHSSIDSISMRKFRIDPSTG 1516
F +P+Y + E + +LQ+EA D D+ ++SY++ +S + + F +DP+TG
Sbjct: 2170 RFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGL--FHVDPTTG 2227
Query: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
+ T LD E + L +M D+ P A + V V D ND+ P P +E V
Sbjct: 2228 TITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVS 2286
Query: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQ 1636
E A LGS + QVT D D G L Y + + F + G +++ D +
Sbjct: 2287 EDALLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDR 2344
Query: 1637 FVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI 1696
+ L + D P A + + V +++ P F YQ + E+ G++++ +SA
Sbjct: 2345 YQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSAT 2401
Query: 1697 SQST-----LIYEVK---DGDINGIFTINPYSGVITT---QKALDYERTSSYQLIIQATN 1745
+ + + Y + DG F+++P +G + T AL ++ + + ++++A +
Sbjct: 2402 DRDSGANGHISYHLASPADG-----FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD 2456
Query: 1746 MA--GMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDA 1803
G A+ ATV++Q+ D+ND+AP F S Y +++E P S + L + ATDA
Sbjct: 2457 HGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTL-------LTLEATDA 2509
Query: 1804 DSNRN-ALLVYQIVESTAKKFFTVDS--------------STGAIRTIANLDHETIAHFH 1848
D +R+ A + Y I+ + F ++ + G + + LD E++ ++
Sbjct: 2510 DGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYN 2569
Query: 1849 FHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSAT 1908
V D G P ++ PV V V DVNDNPPVFT+A + + T VG E+L V A+
Sbjct: 2570 LTVAAADRGQPPQSSVVPVTVT--VLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEAS 2627
Query: 1909 DPDSEVPPELTYSLMEGSLDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSD--GKFY 1963
D D + +++ G F +D +SG L + + + ++ + L+V+ +D G +
Sbjct: 2628 DADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF 2687
Query: 1964 STSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNE--PLKYSILN 2021
+ + VTI V++ D G F + STS++EN T V ++A+ L+YS+L
Sbjct: 2688 ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLE 2747
Query: 2022 PG------NKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIE 2075
G F + S++G ++ VPFD E E + L+V A+ + +L A V V V +
Sbjct: 2748 AGPGPEGREAFALNSSTGELRAR-VPFDYEHTESFRLLVGAA-DAGNLS-ASVTVSVLVT 2804
Query: 2076 DINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPN 2135
++ PVF+ ++ V A G + V A D+D G +G V Y L +F IN
Sbjct: 2805 GEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQT 2864
Query: 2136 SGNVILK 2142
+G + L+
Sbjct: 2865 TGALYLR 2871
Score = 464 bits (1195), Expect = e-130
Identities = 496/1948 (25%), Positives = 846/1948 (43%), Gaps = 238/1948 (12%)
Query: 115 AILNREIQDNYLLIVKGSVRGEDLEAWTK-----VNIQVLDMNDLRPLFSPTTYSVTIAE 169
A L+RE Q+ Y+L V +V G E + V + +L+ N+ P S + +AE
Sbjct: 1058 AALDREAQELYILKVM-AVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAE 1116
Query: 170 STPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVISLSGRLNYDEKNR 226
+ P TSV +V ATD D G NG Y + + F +HP +G ++ L+ ++++
Sbjct: 1117 NQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSS 1176
Query: 227 YDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT---------HVPFSLE 277
Y L + D G + S+T ++V + +N+++PT + VP +
Sbjct: 1177 YQLLVQVQDGG-----SPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVP 1231
Query: 278 KEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFL-AKEGKWLNEYKIKERKQIDWES 336
+ D D+G NG I + + G + F L G+ L + ++
Sbjct: 1232 PGTLVTTLQAKDPDEGENGTI--LYTLTGPGSELFSLHPHSGELLTAAPLIRAER----- 1284
Query: 337 FPYGYNLTLQAKDKGSPQKCSALKAVY-------IGNPTRDTV---PIRFEKEVYDVSIS 386
P+ Y LTL A D+GSP + ++L+ + + P D P V V+ +
Sbjct: 1285 -PH-YVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAA 1342
Query: 387 EFSPPGVVVAIVKLSPEPIDV---EYKLSPGEDAV-YFKINPRSGLIVTARPLNTVKKEV 442
E PG ++ V +PEP V Y L G D F ++ SG + ARPL+
Sbjct: 1343 EGLRPGSLLGSVA-APEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPP 1401
Query: 443 YKLEVTNKEGDLKA-----QVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
++ EG A +V + ++D N+H P F + + E+ G ++ T AS
Sbjct: 1402 WRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRAS 1461
Query: 498 DKD-KGENGYITYSIASLNLLPFV----INQFTGVISTTEELDFESSPEIYRFIVRASDW 552
D D G N + Y + L P V ++ TG +S LD E++P + +V A+D
Sbjct: 1462 DADGPGPNSDVRYRL--LRQEPPVPALRLDARTGALSAPRGLDRETTPALL-LLVEATDR 1518
Query: 553 --GSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDID--EL 608
+ R + V+ + + + NDN+P+F + + + D P G V A D D E
Sbjct: 1519 PANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEA 1577
Query: 609 ELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATD----------- 657
V Y++ SG + G F L+ +G L + + L + L + A+D
Sbjct: 1578 ARVSYRLASGGD-GHFRLHSSTGALSVVRPLDRE--QRAEHVLTVVASDHGSPPRSATQV 1634
Query: 658 ------------------------------GENL-----ADP-MSINISVLHGKVSSKSF 681
G +L DP + N V +G VSS+SF
Sbjct: 1635 LTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESF 1694
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKED--- 738
S +L +A + E+ L Y+ +R P VAV+++
Sbjct: 1695 SLDPDT-------GVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDH 1747
Query: 739 ------------LPVGAN---ILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQL 783
+P G + + ++A D D G NG++ + I DG+ F +D+ +G+
Sbjct: 1748 APTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEF 1807
Query: 784 KVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILES 843
+ P+DRE + L I D G P S+ LLT+ V DAND++P F +YSV + E
Sbjct: 1808 GTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPED 1867
Query: 844 SGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSL 902
GT ++Q++A D D G+NG VTY + T F + S+G + A LDRE +Y+
Sbjct: 1868 VPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTF 1927
Query: 903 KIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGT----VIAWL 958
+ A D A +G L + V++ + + DVND +P F S +++ P + +A L
Sbjct: 1928 SVSAVDGAAAG-PLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATL 1986
Query: 959 ETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
D D G + Y L +D +G IR+++ + L + A D GRP
Sbjct: 1987 RAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRP 2046
Query: 1019 V-SLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGE 1077
S + V V ++ E P FP + +++EN+ GT ++ A G +G
Sbjct: 2047 ARSATGVIIVGLQ----GEAERGPRFPRASSEATIRENAPPGTPIVSPRA-VHAGGTNGP 2101
Query: 1078 IQYSIRDGSGLGRFSIDDESGVIT--AADILDRETMGSYWLTVYATDRGVVPLYSTIEVY 1135
I YSI G+ G FSI +G IT +A+ LD E L + A G ++ +
Sbjct: 2102 ITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA---FAFTVLT 2158
Query: 1136 IEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNP-QN 1194
+ ++D NDNAP P Y + E+ P + ++Q++A+D D S +++Y + + P +
Sbjct: 2159 LTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARG 2218
Query: 1195 FFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF 1254
F ++ TG ITTT+ LDRE AE L + TD G + + V V+D NDN+P
Sbjct: 2219 LFHVDPTTGTITTTA-ILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI 2277
Query: 1255 PEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVS 1314
P+ +++++ E G I + D D GP + Y + F + G VS
Sbjct: 2278 PQP-WELRVSE--DALLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVS 2332
Query: 1315 SRKQFTAGSYDILTIKAVDNGRPQKS-STARLHIEWIKKPPPSPIPLTFDEPFYNFTVME 1373
D ++ + + P + + + +E + P+ F + Y ++E
Sbjct: 2333 LTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPA-----FSQSLYQVMLLE 2387
Query: 1374 SDRVTEIVGVVSV----QPANTPLWFDIVGGNFDSAFDAEKG-VGTIVIAKPLDAEQRSI 1428
+ VS AN + + + + D G + TIV L +
Sbjct: 2388 HTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGA 2447
Query: 1429 YNMSVEVTD---GTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEAT 1485
++ +E D A V +++ D ND+ P F+ +Y V ++ED+ P + +L +EAT
Sbjct: 2448 VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT 2507
Query: 1486 DRDEKHKLSYTVHSSIDSISMRKFRIDP--------------STGVLYTAERLDHEAQDK 1531
D D + +S I R F+++P + G L E LD E+ +
Sbjct: 2508 DADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQ 2567
Query: 1532 HILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTAL 1591
+ L + D+ P + ++ V V V D ND+ P FT Y +V E +G+ +L V A
Sbjct: 2568 YNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEAS 2627
Query: 1592 DKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPM 1651
D D G + + +T+ +G+ +F+++ G + + D T + L ++ D P
Sbjct: 2628 DADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD---PAG 2684
Query: 1652 SATAIVRISVTMSD-NSH-PKFIHKDYQAEVNENVDIGTSVILISAIS---------QST 1700
+ A+ +++ + D N H P F V EN GT V + AI + +
Sbjct: 2685 AHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYS 2744
Query: 1701 LIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIV 1760
L+ + F +N +G + + DYE T S++L++ A + ++++ TV++ +
Sbjct: 2745 LLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVT 2804
Query: 1761 DENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTA 1820
E++ PVFL + + E A SL + ++ATD D + L++Y + +T+
Sbjct: 2805 GEDEYDPVFLAPAFHFQVPEGARRG---HSLGH----VQATDEDGGADGLVLYSL--ATS 2855
Query: 1821 KKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTA--------ESPVEVNIE 1872
+F ++ +TGA+ + V R GS T+ E+P E+ +E
Sbjct: 2856 SPYFGINQTTGAL--------------YLRVDSRAPGSGTATSGGGGRTRREAPRELRLE 2901
Query: 1873 VTDVNDNPPVFTQAVFETILLLPTYVGV 1900
V P + V T+ + T +G+
Sbjct: 2902 VIARGPLPGSRSATVPVTVDITHTALGL 2929
Score = 343 bits (879), Expect = 3e-93
Identities = 358/1360 (26%), Positives = 581/1360 (42%), Gaps = 158/1360 (11%)
Query: 79 IKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAI---LNREIQDNYLLIVKGSVRG 135
+ YR+ SG + F R+ + G ++ L+RE + ++L V S G
Sbjct: 1580 VSYRLASGGDGHF--------------RLHSSTGALSVVRPLDREQRAEHVLTVVASDHG 1625
Query: 136 EDLEAWTKV-NIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFY 194
+ T+V + V D+ND P F YSV + E+ P TS+ + ATD D+G+NG+
Sbjct: 1626 SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVT 1685
Query: 195 YYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYV 254
Y + + FS+ P +GV++ L+ +E+ +L + A DRG + + + V
Sbjct: 1686 YGGVSS-ESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRG-----SPPQLTHVTVRV 1739
Query: 255 HIERINEHAPTI---HVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQ 311
+E N+HAPT H+ VP + + T ++ D D GANG+++ I+ GDP
Sbjct: 1740 AVEDENDHAPTFGSAHLSLEVPEGQDPQ-TLTMLRASDPDVGANGQLQ-YRILDGDPSGA 1797
Query: 312 FFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDT 371
F L L + + +D E P + L ++A+D G P + L D
Sbjct: 1798 FVLD-----LASGEFGTMRPLDREVEP-AFQLRIEARDGGQPALSATLLLTVTVLDANDH 1851
Query: 372 VPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFKINPR 425
P F Y V + E P G + +++L D V Y L G A F + P
Sbjct: 1852 APA-FPVPAYSVEVPEDVPAGTL--LLQLQAHDPDAGANGHVTYYLGAGT-AGAFLLEPS 1907
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEG------DLKAQVTISIEDANDHTPEFQ-QPLYD 478
SG + TA L+ + Y V+ +G VTI++ D NDH P F PL
Sbjct: 1908 SGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRL 1967
Query: 479 AYVNESVPVGTSVL---TVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELD 535
T L T+ A D+D G N I Y +A ++ +TG I
Sbjct: 1968 RLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPV 2027
Query: 536 FESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGG 595
+ FIV A+D G P R + V + + + + P F + + + I + P G
Sbjct: 2028 ALGPRDRVLFIV-ATDLGRPARSATGV-IIVGLQGEAERGPRFPRASSEATIRENAPPGT 2085
Query: 596 HITAVSAIDIDELE-LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRIT 654
I + A+ + Y I+SGNE G F + P +G IT
Sbjct: 2086 PIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGA--------------------IT 2125
Query: 655 ATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLD 714
E L + V+ +L +L+++A++ G L
Sbjct: 2126 VRSAEGL-----------------------DFEVSPRL--RLVLQAESGGAFAFTVLTLT 2160
Query: 715 FYSINRQGPYFDKSFPSDVA-VKEDLPVGANILKIKAYDADSGFNGKVLFTISDGN-TDS 772
N P F + P VA + E P+ +L+++A D D G G++ ++++
Sbjct: 2161 LQDANDNAPRFLR--PHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARG 2218
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFI 832
F++D TG + +DRE L + D G+P LT+ V D NDN P I
Sbjct: 2219 LFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPT-I 2277
Query: 833 QDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDT---QQFAINSSTGIVYVA 889
+ + + E + +G+EI QV D D +G V + VL+ + F++ G V +
Sbjct: 2278 PQPWELRVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSPSGPQDPFSVGRYGGRVSLT 2334
Query: 890 DQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDL 949
LD E Y L++ A D G+ L V ++DVND +PAF S Y V +LE
Sbjct: 2335 GPLDFEQCDRYQLQLLAHDGPHEGR-----ANLTVLVEDVNDNAPAFSQSLYQVMLLEHT 2389
Query: 950 PVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRL---SKELDYEKQQFY 1006
P G+ I + D D G G + Y L + +G F +D +G + + L ++
Sbjct: 2390 PPGSAILSVSATDRDSGANGHISYHLASPADG-FSVDPNNGTLFTIVGTVALGHDGSGAV 2448
Query: 1007 NLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVT 1066
++ + A+D G P ++ + V V++ D N+ H P F +V E+ G+++L +
Sbjct: 2449 DVVLEARDHGAP-GRAARATVHVQLQDQND--HAPSFTLSHYRVAVTEDLPPGSTLLTLE 2505
Query: 1067 ARDEDSGRD-GEIQYSIRDGSGLGRFSIDDE--------------SGVITAADILDRETM 1111
A D D R + YSI G+ F ++ G + + LD E++
Sbjct: 2506 ATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESL 2565
Query: 1112 GSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQ 1171
Y LTV A DRG P S + V + V DVNDN P+ + Y V E++P ++ ++
Sbjct: 2566 TQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVE 2625
Query: 1172 AEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGP 1231
A D D + + + ++SG+P F ++ +G + + LD E QA H L V D P
Sbjct: 2626 ASDADPGPHGLVRFTVSSGDPSGLFELDESSGTL-RLAHALDCETQARHQLVVQAAD--P 2682
Query: 1232 SPKQSTIW-VVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAE 1290
+ + V ++V D ND+ P FP + + E + G + A D D G
Sbjct: 2683 AGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAE--NQPPGTLVTTLHAIDGDAGAFGR 2740
Query: 1291 ISYSIVDG--NDDGK--FFIDPKTGMVSSRKQFTAGSYDI--LTIKAVDNGRPQKSSTAR 1344
+ YS+++ +G+ F ++ TG + +R F + L + A D G S T
Sbjct: 2741 LRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVS 2800
Query: 1345 LHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVV 1384
+ + + P F P ++F V E R +G V
Sbjct: 2801 VLVTGEDEYDP-----VFLAPAFHFQVPEGARRGHSLGHV 2835
Score = 310 bits (795), Expect = 2e-83
Identities = 267/880 (30%), Positives = 403/880 (45%), Gaps = 53/880 (6%)
Query: 2815 ETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGW 2874
+ S D I E P GT + + A + G + Y + S + V ID ++G
Sbjct: 43 QAGSLDLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFI-SAQEGSGVGTDLAIDEHSGV 100
Query: 2875 ISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVK 2934
+ T + LD E + F+ V D +T V+VRV DIND+AP F Q V
Sbjct: 101 VRTARVLDREQRDRYRFTAVTPD-------GATVEVTVRVADINDHAPAFPQARAALQVP 153
Query: 2935 ESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFAL-------GLVQSEWKVYVK 2987
E G + D D + Q Y ++G F L G E + V
Sbjct: 154 EHTAFGTRYPLEPARDADAGRLGTQ-GYALSGDGAGETFRLETRPGPDGTPVPE--LVVT 210
Query: 2988 RPLDREEQDIYFLNITATDGLFV---TQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPS 3044
LDRE + Y L + A DG QA+++V++ D+ND++P +Q Y A++ E +
Sbjct: 211 GELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAP 270
Query: 3045 NKIILKVSAKDADIGSNGYIRYSL---YGSGNSEFFLDPESGELKTLALLDRERIPVYSL 3101
+L+V A DAD G NG + Y + G+ F +D +G L+ LD E+ V+ L
Sbjct: 271 GSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHEL 330
Query: 3102 MAKATDGGGR--FCQSNIHLILEDVNDNPP----VFSSDHYNTCVYENTATKALLTRVQA 3155
+ +A DGG + + + + D NDN P +F S + V E L+ R+
Sbjct: 331 VVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISV 390
Query: 3156 VDPDIGINRKVVYSLADSAGGVFSIDSSSGIIIL---EQPLDREQQSSYNISVRATDQSP 3212
DPD G V SL + G F++ + +I L + LDRE++ +YN+ V ATD S
Sbjct: 391 SDPDDGDFAHVNVSL-EGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATD-SG 448
Query: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVT-VPEDTSPGTQVLAVFATSKDIGTNAEI 3271
L + + V D+NDN P F+R+ Y +PE PG+ V+ V A D GTN ++
Sbjct: 449 SPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQV 508
Query: 3272 TYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINL 3331
TY + G F I+P +G I+ + LDYEL + L+V A DGG P L++ ATV++ L
Sbjct: 509 TYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVAL 568
Query: 3332 TDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSI---VNGDRDNE 3388
DVNDN P+F + Y+A + E G + + A D DS P G + +S+ +
Sbjct: 569 QDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP 628
Query: 3389 FTVDPVLGLVKVKKKLDRER-VSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFT 3447
F +D G V + LDR++ S + V AVD G + S V + +SD NDN P F
Sbjct: 629 FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFY 686
Query: 3448 PANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH-GILRSA 3506
P Y A I P GT++L+L D D +G S+ IL+GN F LD G+L A
Sbjct: 687 PREYAASISAQSPPGTAVLRLRAHDPDQGSHG-RLSYHILAGNSPPLFTLDEQSGLLTVA 745
Query: 3507 VVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFP 3566
+ L + A+D G Q + + ++ + P L+ ED P
Sbjct: 746 WPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAP 805
Query: 3567 GGVIGKIHATDQD--MYDVLTFALKSEQKSLFKVNSHDGKIIALGGLDSGKY--VLNVSV 3622
G +G + A + + V + + LF +++ G + L LD VL + V
Sbjct: 806 GTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEV 865
Query: 3623 SDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPEDFV 3662
G P V V L+ ++ N+ +PED V
Sbjct: 866 RAGSGVPPAFAVARVRVLLDDVNDNSPAF----PAPEDTV 901
Score = 215 bits (548), Expect = 7e-55
Identities = 236/898 (26%), Positives = 383/898 (42%), Gaps = 125/898 (13%)
Query: 32 GLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGF 91
GL G G F + AT+ EN+ T + S + + I Y I+SG+E+G
Sbjct: 2057 GLQGEAERGPRFPRASSEATIRENAPPGTPIVSPR--AVHAGGTNGPITYSILSGNEKGT 2114
Query: 92 FKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDM 151
F + A + +R+ G L+ E+ L+++ G A+T + + + D
Sbjct: 2115 FSIQPSTGA----ITVRSAEG----LDFEVSPRLRLVLQAESGGAF--AFTVLTLTLQDA 2164
Query: 152 NDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF---KNKVDLFSVHP 208
ND P F Y + ES PL + QV A D D GS G+ Y + LF V P
Sbjct: 2165 NDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDP 2224
Query: 209 TSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHV 268
T+G I+ + L+ + L ++A DR G+ + +A L V + N++ PTI
Sbjct: 2225 TTGTITTTAILDREIWAETRLVLMATDR-----GSPALVGSATLTVMVIDTNDNRPTIPQ 2279
Query: 269 VTHVPFSLEK--EPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKI 326
+ S + A VT +D+D +G + + P D F + + G ++
Sbjct: 2280 PWELRVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSPSGPQDPFSVGRYGG-----RV 2331
Query: 327 KERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSIS 386
+D+E Y L L A D P + A V + D P F + +Y V +
Sbjct: 2332 SLTGPLDFEQCD-RYQLQLLAHD--GPHEGRANLTVLV-EDVNDNAP-AFSQSLYQVMLL 2386
Query: 387 EFSPPGVVVAIVKLSPEPI----DVEYKLSPGEDAVYFKINPRSGLIVTARPLNTV---K 439
E +PPG + V + + Y L+ D F ++P +G + T + TV
Sbjct: 2387 EHTPPGSAILSVSATDRDSGANGHISYHLASPADG--FSVDPNNGTLFTI--VGTVALGH 2442
Query: 440 KEVYKLEVTNKEGD-------LKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVL 492
++V + D +A V + ++D NDH P F Y V E +P G+++L
Sbjct: 2443 DGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLL 2502
Query: 493 TVSASDKD-KGENGYITYSIASLN------LLPFVIN---------QFTGVISTTEELDF 536
T+ A+D D + + YSI S N L P + + G + E LDF
Sbjct: 2503 TLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDF 2562
Query: 537 ESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGH 596
ES + Y V A+D G P S V VT+ + +VNDN P+F + + + + D PVG
Sbjct: 2563 ESLTQ-YNLTVAAADRGQP-PQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAE 2620
Query: 597 ITAVSAIDID--ELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRIT 654
+ V A D D LV++ + SG+ G F L+ SG L+L +L
Sbjct: 2621 LLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHAL--------------- 2665
Query: 655 ATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLD 714
C ET+ +L + A A+ L ++
Sbjct: 2666 ---------------------------DC-ETQARHQLVVQAADPAGAH--FALAPVTIE 2695
Query: 715 FYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTD--- 771
+N GP F + S +V E+ P G + + A D D+G G++ +++ +
Sbjct: 2696 VQDVNDHGPAFPLNLLS-TSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEG 2754
Query: 772 -SCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPV 830
F ++ TG+L+ +P D EHT+ + L + D GN S + + ED D PV
Sbjct: 2755 REAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PV 2812
Query: 831 FIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYV 888
F+ ++ + E + G + V+A D+D G++G V YS+ T + F IN +TG +Y+
Sbjct: 2813 FLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYL 2870
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 668 bits (1723), Expect = 0.0
Identities = 662/2439 (27%), Positives = 1100/2439 (45%), Gaps = 215/2439 (8%)
Query: 125 YLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATD 184
+L +VKG G +A+ +V+++ D+ND P+F+P+TY +I++ T T + V ATD
Sbjct: 149 HLALVKG---GLSAQAFVRVDLE--DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATD 203
Query: 185 ADIGSNGEFYYYF--KNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEIL-AVDRGMKLY 241
D G G Y N LF++ T+G+ S ++EIL AV+
Sbjct: 204 QDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS------------PEVEILSAVNFSADKE 251
Query: 242 GNNGVSSTAKLYVH---IERINEHAPTIHVVTHVPFSLEKEPTYA-VVTVDDLDDGANGE 297
N + L H +ER E A + F K + + V D A+GE
Sbjct: 252 VMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGE 311
Query: 298 IESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGY------NLTLQAKDKG 351
+ ++A K L E I + + P + +L + A+D G
Sbjct: 312 AAA-----------RYVANLAKILGE-------GIIYLTLPLSHLESTTLSLMVSAQDGG 353
Query: 352 S-PQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID---- 406
+A ++I T P FE+ Y + E P + VK + EP++
Sbjct: 354 GLTAVINADVTIHIFQTT--LAPAEFERPKYTFLVYEDVPEDSPIGTVK-AREPLNSSEP 410
Query: 407 VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKA----QVTISI 462
+ Y++S G+ F I+PR G I T +PL+ + V L V + G A +V I++
Sbjct: 411 IFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITV 470
Query: 463 EDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVIN 522
D ND+ P F + + ++++ P GT++ A D+D G NG I YSIAS F I+
Sbjct: 471 MDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAID 530
Query: 523 QFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSP--LFEK 580
+ GV+ L E+ +RA D G ++ + V + ++SP FE
Sbjct: 531 RALGVLFLNGSLGAGEQREL-TLTLRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEH 587
Query: 581 VACQGVISYDFPVGGHITAVSAIDIDELEL---VKYKIISGNELGFFYLNPDSGVLQLKK 637
+ Q +S + A + ++Y + + F + P +G + L++
Sbjct: 588 LVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRR 647
Query: 638 SLTNSGIKNGNFALRITA---TDG--ENLADPMSINI--------SVLHGKVSSKSFSCR 684
+ NF R+ A DG +N++ + + + + LH + K
Sbjct: 648 QFDYESTQTYNF--RVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLK---VE 702
Query: 685 ETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGAN 744
E+ V Q + K+ +GK N Q YF S + +
Sbjct: 703 ESPVPQGVIGKITAIDMDSGK-------------NGQLLYFLLSDGKFFKMNPNTGPAGT 749
Query: 745 ILKIKAYDADSGFNGKVLFTISD---GNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNI 801
I I D + F+G SD ++ G+L + +DREH + + +
Sbjct: 750 IYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTV 809
Query: 802 TIYDLGNPQKSSWRLLTINVEDANDNSPVFIQ----DSYSVNILESSGIGTEIIQVEARD 857
+ D G+P +++ + ++V D NDN P F Q V +LE + + V A+D
Sbjct: 810 LVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKD 869
Query: 858 KDLGSNGEVTYSVLTD--TQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQ 915
D G+N EVTYSV ++ + F I+++ G + L + + +Y + + A D+ Q
Sbjct: 870 PDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQ 929
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVL---EDLPVGTVIAWLETHDP-DLGLGGQV 971
+VV ++V S S +++ L E+L +++ +++ D G++
Sbjct: 930 GQAVVNIQVI-----PLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKL 984
Query: 972 RYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
+S+V +D +G FEID ++G + LSKELDYE Y V D + +SLSS F+ ++
Sbjct: 985 HFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSID 1044
Query: 1031 VVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDED-SGRDGEIQYSIRD-GSGL 1088
V D N+ H+P F D +V SV+EN IGT V A+D+D S + IQY I G
Sbjct: 1045 VEDQND--HSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGT 1102
Query: 1089 GRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL---YSTIEVYIEVEDVNDNA 1145
F I G + LDRE++ + LTV A+D+ V ++ I + DVND+
Sbjct: 1103 NPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHN 1162
Query: 1146 PLTSEPIYYP--VVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTG 1203
P I +P V E+ V I A DPD N K+TY I SGN F ++ +G
Sbjct: 1163 PTF---ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSG 1219
Query: 1204 LITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKL 1263
L+TTT LD E + +H L V D G S+ + V VLD ND P F + +Y+ +
Sbjct: 1220 LLTTTC-PLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASV 1278
Query: 1264 PERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGS 1323
++ + GE + R A DRD G N+++ + I+ G F I+ TG V +
Sbjct: 1279 --KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREI 1336
Query: 1324 YDILTIKAV--DNGRPQKSSTARL--HIEWIKKPPPSPIPLTFD-------EPFYNFTVM 1372
++ T++ + D G P SST + +E P I ++D EP +TV+
Sbjct: 1337 QEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL 1396
Query: 1373 ESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMS 1432
SD N + + I+ GN D F + G + + LD EQ S + +
Sbjct: 1397 ASDMDA---------GNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLV 1447
Query: 1433 V---EVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
+ ++ D +V + ++VLD ND+ P F Y ++ ED T +L + A D+DE
Sbjct: 1448 ILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDE 1507
Query: 1490 KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNL 1549
L+ + + F IDP +G L T+ LD EA+ +H + + RD R+
Sbjct: 1508 --GLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRST 1565
Query: 1550 ARVI-VNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAG 1608
+I V V D ND+ P ++ + + + V A D D G N ++++
Sbjct: 1566 TVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF--A 1623
Query: 1609 NTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSH 1668
T +MF I+ G I + P + L +KVTDQG P + T ++ I + ++
Sbjct: 1624 ETQSMFSIDKYTGEIQFQQNPS-SEYFPIWLQLKVTDQGIPARTTTGLLVIHME-GEDVK 1681
Query: 1669 PKFIHKDYQAEVNENVDIGTSVILISAIS----QSTLIYEVKDGDINGIFTINPYSGVIT 1724
F H Y+ V EN + GTS++ + A + Q ++ Y + G+ +G+ ++ SG +T
Sbjct: 1682 ISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLT 1741
Query: 1725 TQ--KALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAA 1782
+ K LD+E + QLI+ A + +G + V + I DENDN+P F S Y S+SE+
Sbjct: 1742 VKEPKFLDFEVRNEVQLIVLAES-SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQ 1800
Query: 1783 PINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHE 1842
N+ V + + ATD DS N L+ Y I+ ++ F +D+ +G I T A LD+E
Sbjct: 1801 LYNAHV-------IQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYE 1853
Query: 1843 TIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVF--TQAVFETILLLPTYVGV 1900
+ + V D G P+L+ + + ++VTD+NDN P F ++AV T LP GV
Sbjct: 1854 LTSSYSLIVQATDKGMPRLS--NTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP---GV 1908
Query: 1901 EVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLT-IKNNNLSK-DHYMLIVKVS 1958
V VS D D +++ F ID N+GV+ +K + + Y L++++S
Sbjct: 1909 IVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQIS 1968
Query: 1959 DGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYS 2018
D Y+ + + V + D+ F+Q FY ++ E+ V ++A NE + Y
Sbjct: 1969 DSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYR 2028
Query: 2019 ILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDIN 2078
IL+ +F I +G I T + + +VEAS + A +V + IED+N
Sbjct: 2029 ILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMN 2088
Query: 2079 DNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKD------------KGPNGEVTYVLQDD 2126
+ +P F Y ++ DA G+ + + ID D N + + ++
Sbjct: 2089 NYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETK 2148
Query: 2127 YGHFEI-NPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI--VNKAM 2183
+ H E G ++L + + + S + + ILA D G P LS++ + I + VN
Sbjct: 2149 FFHSEYPYKQVGYLVLLHSLDREAS-ASHELVILASDSGCPPLSSTAVISIQVLDVNDNP 2207
Query: 2184 PVFDKPFYTASVNEDIRMNTPILSINATSPEGQG---IIYIIIDGDPFKQFNIDFDTGVL 2240
P F Y V E + + I ++A + IIY II G+ F ++ +TGVL
Sbjct: 2208 PNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVL 2267
Query: 2241 KVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEAS 2300
++ PLDYE + + LT++ASDA + V + V D ND+ P F +++ + E
Sbjct: 2268 YLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENL 2327
Query: 2301 LIGTPVLQVVSIDADSENNKMVHYQIVQDTY------NSTDYFHIDSSSGLILTARMLDH 2354
I + + + ++D D+ + Y IV + D F ID +G I ++LD+
Sbjct: 2328 PISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDY 2387
Query: 2355 ELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVT 2414
E L V++ D G ++ ++V + I +++ P+F Q Y + E +
Sbjct: 2388 ENGNKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIG 2445
Query: 2415 CVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITL 2453
V+ASDAD+ + YS+ G F ++ +G I L
Sbjct: 2446 RVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYL 2482
Score = 627 bits (1617), Expect = e-179
Identities = 660/2512 (26%), Positives = 1081/2512 (43%), Gaps = 283/2512 (11%)
Query: 285 VTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWL-----NEYKIKERKQIDWESFPY 339
VT D D G G IE S+ G FL+ E ++ +I + ID E P
Sbjct: 79 VTASDADSGLYGFIE-YSLYDG------FLSYEAPQAFRIDPHDGQICVSQDIDRERDPA 131
Query: 340 GYNLTLQAKDKGSPQKCSALKAVYIG-----------NPTRDTVPIRFEKEVYDVSISEF 388
Y+L ++AKD G Q+ + L V G D P+ F Y SIS+
Sbjct: 132 TYDLLVEAKD-GDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPV-FNPSTYVTSISDE 189
Query: 389 SPPGVVVAIVKLSPEPID----VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYK 444
+ PG + V + + V Y+L PG + F I+ +GL EV
Sbjct: 190 TQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLY---------SPEVEI 240
Query: 445 LEVTNKEGDLKAQVTISI--------------EDANDHTPEFQQPLYDAYVNESVPVGTS 490
L N D + ++ + E+A + E + + +
Sbjct: 241 LSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK 300
Query: 491 VLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRAS 550
V +AS + Y+ L G+I T L S + +V A
Sbjct: 301 VQDEAASADGEAAARYVANLAKILG---------EGIIYLTLPLSHLESTTL-SLMVSAQ 350
Query: 551 DWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAID-IDELE 609
D G +VTI I FE+ ++ D P I V A + ++ E
Sbjct: 351 DGGG-LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
Query: 610 LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINI 669
+ Y+I SG+ G F ++P G ++ +K L + + + +
Sbjct: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDH---------------------ETQPVVV 448
Query: 670 SVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSF 729
+ ++ S +C T V + +N P F ++
Sbjct: 449 LTVQAQLGSAP-ACSSTEVN-----------------------ITVMDVNDNHPAFLRT- 483
Query: 730 PSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPM 789
++ + + P G + +A D DSG NG + ++I+ F ID G L + +
Sbjct: 484 SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGVLFLNGSL 542
Query: 790 DREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSP--VFIQDSYSVNILESSGIG 847
L + D G +++ +LT+ +E ++SP F Y V + ES
Sbjct: 543 GAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK-REHSPSWTFEHLVYQVEVSESLSPM 601
Query: 848 TEIIQVEARDKDLGSN---GEVTYSV--LTDTQQFAINSSTGIVYVADQLDRESKANYSL 902
T+++Q +A LG + YS+ D+ F I TG +Y+ Q D ES Y+
Sbjct: 602 TQMLQTQAHP--LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNF 659
Query: 903 KIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHD 962
++ A + Q S T+ V + D ND SP F+ +KV E VI + D
Sbjct: 660 RVFAWIPEDGFLQNVST-TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAID 718
Query: 963 PDLGLGGQVRYSLVNDYNGRF--------------EIDKASGAIRLSKE----------- 997
D G GQ+ Y L++D G+F I A GA S
Sbjct: 719 MDSGKNGQLLYFLLSD--GKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
Query: 998 --------------------LDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNEN 1037
LD E + + +TV D+G P ++++ V V V D+N+N
Sbjct: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMA-VYVSVTDINDN 835
Query: 1038 LHTPYFPDFA----VVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSI 1093
P+FP + V E + V V A+D D G + E+ YS+ F I
Sbjct: 836 --RPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKI 893
Query: 1094 DDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
D +G I IL + SY ++V ATD+GV PL V I+V ++ + S+ I
Sbjct: 894 DANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIR 953
Query: 1154 YPVVMEN-SPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
+ ++ EN P + + ++ N KL + I + + F I+ TG + S++L
Sbjct: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDL-FLSKEL 1012
Query: 1213 DREQQAEHFLEVTVTDGGPS-PKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKR 1271
D E + + V TD + ST+++ + V D+ND+ P F +++ I + E
Sbjct: 1013 DYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEE--NVPI 1070
Query: 1272 GEPIYRAFAFDRDEGP--NAEISYSIVDGN-DDGKFFIDPKTGMVSSRKQFTAGSYD--I 1326
G +Y F D+G N+ I Y I N F I P G + + + S I
Sbjct: 1071 GTLVY-VFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
Query: 1327 LTIKAVDNG-----RPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV 1381
LT+ A D R +S TA++ I + P+ I F N V E V +V
Sbjct: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI------SFPNAHVKEDVTVGSLV 1183
Query: 1382 GVVSV----QPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD 1437
++ + N + + I+ GN + F ++ G + PLD E ++ + ++V D
Sbjct: 1184 HHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALD 1243
Query: 1438 GTNVAVTQ---VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE--KHK 1492
A++ + + VLD ND P F Q Y+ ++ E+ P + ++EA DRD K
Sbjct: 1244 DGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSK 1303
Query: 1493 LSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARV 1552
L + + + S F I+ TG + T LD E Q+ L ++VRD FP + +
Sbjct: 1304 LQFEI---MPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTI 1360
Query: 1553 IVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGN 1612
+ VED NDH+P F Y+ V E+ V V A D D G N + Y I GNT
Sbjct: 1361 LCTVEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVLASDMDAGNNRAVEYHIIDGNTDE 1419
Query: 1613 MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFI 1672
F I + G ++ + D + F L I +D G PP S+ +++ V +++ P F
Sbjct: 1420 CFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFP 1479
Query: 1673 HKDYQAEVNENVDIGTSVILISAISQSTLI-----YEVKDGDINGIFTINPYSGVITTQK 1727
YQ+ V E+ ++GT V+++SA+ + + Y + D + +G FTI+P SG + T
Sbjct: 1480 TLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD-EASGAFTIDPMSGTLKTSN 1538
Query: 1728 ALDYERTSSYQLIIQATNMAGMASNAT---VNIQIVDENDNAPVFLFSQYSGSLSEAAPI 1784
LD E S + A + + S +T + + + D NDN PV + + LS +P
Sbjct: 1539 TLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPT 1598
Query: 1785 NSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETI 1844
N + +++RA D D N +V+ E+ + F++D TG I+ N E
Sbjct: 1599 N-------QTTVIVRADDLDLGPNGTVVFSFAET--QSMFSIDKYTGEIQFQQNPSSEYF 1649
Query: 1845 AHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLK 1904
+ V D G P T + +++E DV + F+ +++ ++ G ++
Sbjct: 1650 P-IWLQLKVTDQGIPARTTTGLLVIHMEGEDVKIS---FSHHLYKGLVTENCEAGTSIVT 1705
Query: 1905 VSATDPDSEVPPELTYSLMEGSLDHFL-IDSNSGVLTIKNNNL----SKDHYMLIVKVSD 1959
V A PDS + + YS+ G+ D L + S SG LT+K ++ LIV
Sbjct: 1706 VKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES 1764
Query: 1960 GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISEN---NTNITKVAIVNAVGNRLNEPLK 2016
+ V +++++ D+ F QS Y S+SE+ N ++ +V + + LN ++
Sbjct: 1765 SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQV-FATDLDSGLNGLIE 1823
Query: 2017 YSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNI 2074
YSIL N F+I + SGVI T + D E Y L+V+A+ + V++V +
Sbjct: 1824 YSILSGNQEEAFQIDALSGVITTKAI-LDYELTSSYSLIVQATDKGMPRLSNTTVIKVQV 1882
Query: 2075 EDINDNSPVFVGLPYYAA-VQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYG-HFEI 2132
DINDN+P F LP A + D+ PG ++ V+ D D ++ + + G F I
Sbjct: 1883 TDINDNAPAF--LPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAI 1940
Query: 2133 NPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYT 2192
+ N+G V+L + + + EY + I D + V + + VN PVF + FY
Sbjct: 1941 DQNTGVVVLVKTLDFE-EMTEYELLIQISDSVHYTEGALV-VRVLDVNDNPPVFSQDFYQ 1998
Query: 2193 ASVNEDIRMNTPILSINATSPE-GQGIIYIIIDGDPFKQFNIDFDTGVLKVVSP-LDYEV 2250
+V E I + +L+++AT E + I Y I+ K+F+ID G + +SP L +
Sbjct: 1999 VTVPESIPVGYSVLTLSATDLESNENISYRILSSS--KEFSIDPKNGTIFTISPVLLLDT 2056
Query: 2251 TSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQV 2309
S + + ASD RA V++ + D+N+ P F +YN +LSE +L+G+ ++
Sbjct: 2057 ISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTF 2116
Query: 2310 VSIDAD-SENNKMVHYQIVQDTYNSTDYFHIDS----------SSGLILTARMLDHELVQ 2358
+ID D + N V Y I+ NS + FH+++ G ++ LD E
Sbjct: 2117 SNIDHDWTRENTYVEYSIISG--NSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASA 2174
Query: 2359 HCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQA 2418
L + + DSG P LSS ++ I + DVNDNPP F+ L Y ++V E P G +T V A
Sbjct: 2175 SHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSA 2234
Query: 2419 SDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG--LF 2476
+D D+ + Y+I+SGN++ F ++ +GV+ L ++L V SD
Sbjct: 2235 NDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKH 2294
Query: 2477 TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAII 2536
S A V + VL N ++P F S++ V EN+ + + + A D D G YG+++Y+I+
Sbjct: 2295 FSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIV 2354
Query: 2537 N--------DFAKDRFLIDS-NGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVR 2587
+ + D FLID G + + LD EN + V+A D G T V
Sbjct: 2355 SPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYEN--GNKYCLTVQAKDKGDATASLVVW 2412
Query: 2588 VIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSL 2639
V + ++ P F +Y ++ L+ +V+A D D G + I YSL
Sbjct: 2413 VDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
Score = 595 bits (1533), Expect = e-169
Identities = 680/2503 (27%), Positives = 1070/2503 (42%), Gaps = 252/2503 (10%)
Query: 747 KIKAYDADSGFNGKVLFTISDG----NTDSCFNIDMETGQLKVLMPMDREHTDL-YLLNI 801
++ A DADSG G + +++ DG F ID GQ+ V +DRE Y L +
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
Query: 802 TIYDLGNPQK-----------SSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEI 850
D G+ Q+ S+ + +++ED NDN PVF +Y +I + + GTEI
Sbjct: 138 EAKD-GDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
Query: 851 IQVEARDKDLGSNGEVTYSVLTD--TQQFAINSSTGIVYVADQLDRESKANYSLKIEARD 908
I V A D+D G G V Y ++ + F I+S+TG+ + +++ S N+S E +
Sbjct: 197 INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVEILSAVNFSADKEVMN 254
Query: 909 KAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLG 968
E L L+ F D A S + +L+ D
Sbjct: 255 SLEMFLPL-----LRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASAD 309
Query: 969 GQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVE 1028
G+ Y G I L+ L + + +L V A+D G L++V +
Sbjct: 310 GEA----AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGG---GLTAVINAD 362
Query: 1029 VEVVDVNENLHTPYFP----DFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD 1084
V + L F F V V E+S IGT V AR E I Y I
Sbjct: 363 VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT----VKAR-EPLNSSEPIFYRISS 417
Query: 1085 GSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDN 1144
G G+FSI G I LD ET LTV A G P S+ EV I V DVNDN
Sbjct: 418 GDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDN 476
Query: 1145 APL---TSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIK 1201
P TS+ I + + +P ++ +AED DS N + Y I S P FAI+
Sbjct: 477 HPAFLRTSDEIR---ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRA 532
Query: 1202 TGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQ--FPEKVY 1259
G++ L +Q E L + D G P Q+ + V+ V+++ ++ P F VY
Sbjct: 533 LGVLFLNG-SLGAGEQRELTLTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVY 590
Query: 1260 QIKLPE------RDRKKRGEPIYRAFAFDRDEGPN---AEISYSIVDGNDDGKFFIDPKT 1310
Q+++ E + + + P+ GP + + YS+ D F I P T
Sbjct: 591 QVEVSESLSPMTQMLQTQAHPL----------GPQRAASPLRYSLEPSVDSAMFGIRPYT 640
Query: 1311 GMVSSRKQFTAGSYDILTIKAV----DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPF 1366
G + R+QF S + ++G Q ST + W + SP TF
Sbjct: 641 GWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW-DENDNSP---TFLHDV 696
Query: 1367 YNFTVMESDRVTEIVGVVSVQPANTP-----LWFDIVGGNF------------------- 1402
V ES ++G ++ ++ L+F + G F
Sbjct: 697 LFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWA 756
Query: 1403 ---------DSAFDA-------------EKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
D AF + E G G ++ LD E R + M+V VTD +
Sbjct: 757 DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGS 816
Query: 1441 V---AVTQVFIKVLDNNDNGPEFSQ----PNYDVTISEDVLPDTEILQIEATDRDEKHKL 1493
A V++ V D NDN P F Q V + E + + + A D DE +
Sbjct: 817 PPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNA 876
Query: 1494 SYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVI 1553
T S + S F+ID + G + T L ++ + + ++++ DQ P + A V
Sbjct: 877 EVTYSVSSED-SSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVN 935
Query: 1554 VNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDK-DKGENAELIYTIEAGNTGN 1612
+ V + + + + E+ + + + D + N +L ++I A +
Sbjct: 936 IQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDG 995
Query: 1613 MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG-SPPMSATAIVRISVTMSDNSHPKF 1671
F+I+ G + + KE D T ++ + TD + +S+T + I V ++ P F
Sbjct: 996 HFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSF 1055
Query: 1672 IHKDYQAEVNENVDIGTSVILISA-------ISQSTLIYEVKDGDINGIFTINPYSGVIT 1724
+ V ENV IGT V + +A ++ Y F I+P G +
Sbjct: 1056 QDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLV 1115
Query: 1725 TQKALDYERTSSYQLIIQATNMAGMAS-----NATVNIQIVDENDNAPVFLFSQYSGSLS 1779
T LD E + L + A++ A + + T I I+D ND+ P F+ S + +
Sbjct: 1116 TVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVK 1174
Query: 1780 EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANL 1839
E + S+V I A D D RN + Y I+ F +D S+G + T L
Sbjct: 1175 EDVTVGSLVHH-------ITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPL 1227
Query: 1840 DHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVG 1899
D+E V D G+P L++ + V V DVND PVF Q ++E + G
Sbjct: 1228 DYEMKTQHILTVLALDDGTPALSSSQTLTVT--VLDVNDEAPVFKQHLYEASVKENQNPG 1285
Query: 1900 VEVLKVSATDPDSEVPPELTYSLMEG-SLDHFLIDSNSG--VLTIKNNNLSKDHYMLIVK 1956
V +V A D DS V +L + +M G S + F I+S++G V T + ++ + L V
Sbjct: 1286 EFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVL 1345
Query: 1957 VSDGKFYSTSMVTIM---VKEAMDSGLHFTQSFYSTSISEN-NTNITKVAIVNAVGNRLN 2012
V DG F S S T + V++ D F S Y + EN + + + + N
Sbjct: 1346 VRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNN 1405
Query: 2013 EPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVV 2070
++Y I+ N F I SG + TT DRE+ + LV+ S D R + + +
Sbjct: 1406 RAVEYHIIDGNTDECFTINEMSGELSTTRA-LDREQISNFTLVILCSDLGDPPRSSVIHL 1464
Query: 2071 RVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDD-YGH 2129
+V + D ND+SP F L Y ++V+ DAE GT++ ++A+DKD+G NG+ Y L D+ G
Sbjct: 1465 QVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGA 1524
Query: 2130 FEINPNSGNVILKEAFNSDLSNIEYGVTILAKD---GGKPSLSTSVELPITIVNKAMPVF 2186
F I+P SG + + + + ++ + +A+D G S + +++ +T VN PV
Sbjct: 1525 FTIDPMSGTLKTSNTLDRE-ARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVL 1583
Query: 2187 DKPFYTASVNEDIRMNTPILSINATSPE-GQGIIYIIIDGDPFKQFNIDFDTGVLKVVSP 2245
++ + ++ + N + + A + G + + F+ID TG ++
Sbjct: 1584 EQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQN 1643
Query: 2246 LDYEVTSAYKLTIRASDALTGARAEVTVDLLV--NDVNDNPPIFDQPTYNTTLSEASLIG 2303
E + L ++ +D G A T LLV + D F Y ++E G
Sbjct: 1644 PSSEYFPIW-LQLKVTD--QGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAG 1700
Query: 2304 TPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSG--LILTARMLDHELVQHCT 2361
T ++ V + DS + M Y I N + S SG + + LD E+
Sbjct: 1701 TSIVTVKAFAPDSIQDSM-KYSIFSG--NEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQ 1757
Query: 2362 LKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDA 2421
L V + SG + V + I D NDN P F Q IY++ VSE V V A+D
Sbjct: 1758 LIVLAESSGHRAYCK---VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDL 1814
Query: 2422 DSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD-GL--FTS 2478
DS +EYSILSGN +F +D+ SGVIT + YSL V +D G+ ++
Sbjct: 1815 DSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSN 1874
Query: 2479 TAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIIND 2538
T + ++V N +PAF S V E+ E+ G V HV D D ++ A I
Sbjct: 1875 TTVIKVQVTDINDNAPAFLPSEAV-EITEDSLPGVIVTHVSVHDVD------LNSAFIFS 1927
Query: 2539 FAKD-----RFLIDSN-GQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVD 2592
FAK+ +F ID N G V+ + LD E E ++ I + T + V V+D
Sbjct: 1928 FAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLI---QISDSVHYTEGALVVRVLD 1984
Query: 2593 ENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLE 2652
NDN P F Y+ +V + G+ V + A D + +N I+Y + S +
Sbjct: 1985 VNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLE--SNENISYRILSSSKE-----FS 2037
Query: 2653 IDPDNGWMVTKGNFNQLKN-TVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQS 2711
IDP NG + T L + F V+A DGG P +L V I + + P FT
Sbjct: 2038 IDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVK 2097
Query: 2712 QYSFTIAEDTAIGSTVDTLRIL------PSQNVWFSTVNGERPENNKGGIFVIE------ 2759
Y+ +++ED +GST+ T + + V +S ++G N F +E
Sbjct: 2098 SYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN-----FHVETKFFHS 2152
Query: 2760 ----QETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
++ G + L LDRE S A H V + T + I+VLD+NDN P F
Sbjct: 2153 EYPYKQVGYLVLLHSLDREAS-ASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFS 2211
Query: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
+ SY T + E P+G+ +T V A D D G++ ++ Y++ S ++ F ++ NTG +
Sbjct: 2212 SLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGH----FYLEENTGVL 2267
Query: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
+K LD+E FT +V ASD + S A+V V V D ND+AP F + V E
Sbjct: 2268 YLIKPLDYEKMTKFTLTVQASDAEKKH--FSFAVVFVSVLDDNDHAPQFMFSSFSCIVPE 2325
Query: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHI------TGGNPRGRFALGLVQSEWKVYVKRP 2989
+ P + ++ D D +++Y I T G + ++ K+
Sbjct: 2326 NLPISSTICSINALDFDAGPYG-ELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQI 2384
Query: 2990 LDREEQDIYFLNITATD-GLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKII 3048
LD E + Y L + A D G +V V + +++ P+ Q Y LPE ++I
Sbjct: 2385 LDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLI 2444
Query: 3049 LKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALL 3091
+V A DAD G +G I YSL G+ + F ++ +G + + L
Sbjct: 2445 GRVEASDADAGIDGVILYSL-GTSSPFFSVNKTNGNIYLIRAL 2486
Score = 556 bits (1434), Expect = e-157
Identities = 593/2248 (26%), Positives = 1005/2248 (44%), Gaps = 194/2248 (8%)
Query: 265 TIHV--VTHVPFSLEKEPTYAVVTVDDL-DDGANGEIESVSIVAGDPLDQ----FFLAKE 317
TIH+ T P E+ P Y + +D+ +D G ++ A +PL+ F+
Sbjct: 364 TIHIFQTTLAPAEFER-PKYTFLVYEDVPEDSPIGTVK-----AREPLNSSEPIFYRISS 417
Query: 318 GKWLNEYKI-------KERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRD 370
G ++ I + RK +D E+ P LT+QA+ GS CS+ + D
Sbjct: 418 GDLGGKFSIHPRLGTIRTRKPLDHETQPVVV-LTVQAQ-LGSAPACSSTEVNITVMDVND 475
Query: 371 TVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID----VEYKLSPGEDAVYFKINPRS 426
P F + ++ IS+ +PPG + + + + Y ++ + V F I+
Sbjct: 476 NHPA-FLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV-FAIDRAL 533
Query: 427 GLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHTPE--FQQPLYDA 479
G++ L ++ L + ++ + Q +T+ IE +H+P F+ +Y
Sbjct: 534 GVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK-REHSPSWTFEHLVYQV 592
Query: 480 YVNESVPVGTSVLTVSASDKDKGENGY-ITYSIA-SLNLLPFVINQFTGVISTTEELDFE 537
V+ES+ T +L A + YS+ S++ F I +TG I + D+E
Sbjct: 593 EVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYE 652
Query: 538 SSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLF----------EKVACQGVI 587
S+ + Y F V A + V +R+ + NDNSP F E QGVI
Sbjct: 653 ST-QTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVI 711
Query: 588 SYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNG 647
G ITA+ +L+ + + G FF +NP++G + T I
Sbjct: 712 -------GKITAIDMDSGKNGQLLYFLLSDGK---FFKMNPNTG-----PAGTIYVITWA 756
Query: 648 NFALRITATDGENLADPM------SINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAK 701
+ A + TD +D + S+ + G++ + RE R ++ +L+ +
Sbjct: 757 DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMT--VLVTDR 814
Query: 702 ANGKLNLEDG-FLDFYSINRQGPYFDKSFPSD---VAVKEDLPVGANILKIKAYDADSGF 757
+ N ++ IN P+F + P V V E PV + + A D D G
Sbjct: 815 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 874
Query: 758 NGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLL 817
N +V +++S ++ F ID G+++ + ++ Y +++ D G P ++
Sbjct: 875 NAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Query: 818 TINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ 875
I V + + Q+ + I E+ T+I+ + L NG++ +S++ D +
Sbjct: 935 NIQVIPLSKGRAIMSQNIRHLIIPENLK-PTKIMSLIKSSDHLQQHYNGKLHFSIVADDK 993
Query: 876 Q--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCS 933
F I+SSTG ++++ +LD E+ ++Y ++ D +++ L S V L + ++D ND S
Sbjct: 994 DGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN-LSLSSTVFLSIDVEDQNDHS 1052
Query: 934 PAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLG-LGGQVRYSLVNDYNGR--FEIDKASG 990
P+F + V E++P+GT++ D D L +++Y + + G F I + G
Sbjct: 1053 PSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFG 1112
Query: 991 AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVG 1050
+ LD E LTV A D+ V+ + + ++V ++ N H P F F
Sbjct: 1113 TLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNA- 1171
Query: 1051 SVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRET 1110
VKE+ +G+ V +TA D D GR+G++ YSI G+ F +D+ SG++T LD E
Sbjct: 1172 HVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEM 1231
Query: 1111 MGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI 1170
+ LTV A D G L S+ + + V DVND AP+ + +Y V EN V ++
Sbjct: 1232 KTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRV 1291
Query: 1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG 1230
+A D DS N KL + I G F IN TG + TT+ LDRE Q L V V DGG
Sbjct: 1292 EALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTT-ILDREIQEVFTLRVLVRDGG 1350
Query: 1231 PSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAE 1290
ST ++ V DEND+ P+F Y I++ E + E +Y A D D G N
Sbjct: 1351 FPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLE---NQEPEVVYTVLASDMDAGNNRA 1407
Query: 1291 ISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAG--SYDILTIKAVDNGRPQKSSTARLHIE 1348
+ Y I+DGN D F I+ +G +S+ + S L I D G P +SS L +
Sbjct: 1408 VEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVR 1467
Query: 1349 WIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFD---IVGGNFDSA 1405
+ SP +F +Y +V E V +V V+S + L + A
Sbjct: 1468 VLDANDHSP---SFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGA 1524
Query: 1406 FDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD----GTNVAVTQVFIKVLDNNDNGPEFS 1461
F + GT+ + LD E RS + S D G+ + + V D NDN P
Sbjct: 1525 FTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLE 1584
Query: 1462 QPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTA 1521
Q +DV +S + + + + A D D V S ++ SM F ID TG +
Sbjct: 1585 QNPFDVFLSPESPTNQTTVIVRADDLDLGPN-GTVVFSFAETQSM--FSIDKYTGEIQFQ 1641
Query: 1522 ERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAAL 1581
+ E L + V DQ P R +++++E D F++ LY+ V E+
Sbjct: 1642 QNPSSE-YFPIWLQLKVTDQGIPARTTTGLLVIHME-GEDVKISFSHHLYKGLVTENCEA 1699
Query: 1582 GSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEP---DMTTMGQFV 1638
G++++ V A D +++ + Y+I +GN + + G +T+ KEP D +
Sbjct: 1700 GTSIVTVKAFAPDSIQDS-MKYSIFSGNEDGVLSLCSKSGQLTV-KEPKFLDFEVRNEVQ 1757
Query: 1639 LSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAIS- 1697
L + G A V + + +++ P F YQA V+E+ VI + A
Sbjct: 1758 LIVLAESSGH---RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDL 1814
Query: 1698 ----QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMAS 1751
+ Y + G+ F I+ SGVITT+ LDYE TSSY LI+QAT+ M +++
Sbjct: 1815 DSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSN 1874
Query: 1752 NATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALL 1811
+ +Q+ D NDNAP FL S+ ++ P +V + D + N+
Sbjct: 1875 TTVIKVQVTDINDNAPAFLPSEAVEITEDSLP----------GVIVTHVSVHDVDLNSAF 1924
Query: 1812 VYQIV-ESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVN 1870
++ ES F +D +TG + + LD E + + + + DS + +
Sbjct: 1925 IFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS-----VHYTEGALV 1979
Query: 1871 IEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHF 1930
+ V DVNDNPPVF+Q ++ + VG VL +SATD +S ++Y ++ S + F
Sbjct: 1980 VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN--ENISYRILSSSKE-F 2036
Query: 1931 LIDSNSGVLTIKNNNLSKDHY---MLIVKVSDG---KFYSTSMVTIMVKEAMDSGLHFTQ 1984
ID +G + + L D +V+ SDG + ++V I +++ + FT
Sbjct: 2037 SIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTV 2096
Query: 1985 SFYSTSISEN---NTNITKVAIVNAVGNRLNEPLKYSIL--NPGNKFKIKS----TSGVI 2035
Y+ S+SE+ + + + ++ R N ++YSI+ N N F +++ +
Sbjct: 2097 KSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPY 2156
Query: 2036 QTTGV-----PFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYY 2090
+ G DRE +ELV+ AS + V+ + + D+NDN P F L Y+
Sbjct: 2157 KQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH 2216
Query: 2091 AAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY--VLQDDYGHFEINPNSGNVILKEAFNSD 2148
V+ G+ I V+A D+D G + E+ Y + ++ GHF + N+G + L + + +
Sbjct: 2217 THVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYE 2276
Query: 2149 LSNIEYGVTILAKDGGKPSLSTSVE-LPITIVNKAMPVFDKPFYTASVNEDIRMNTPILS 2207
++ +T+ A D K S +V + + N P F ++ V E++ +++ I S
Sbjct: 2277 -KMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICS 2335
Query: 2208 INA----TSPEGQGIIYIIID------GDPFKQ--FNIDFDTGVLKVVSPLDYEVTSAYK 2255
INA P G+ + Y I+ G + F ID TG + LDYE + Y
Sbjct: 2336 INALDFDAGPYGE-LTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYC 2394
Query: 2256 LTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDAD 2315
LT++A D A A + V + + +++ PIF Q Y TL E + + +V + DAD
Sbjct: 2395 LTVQAKDK-GDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDAD 2453
Query: 2316 SENNKMVHYQIVQDTYNSTDYFHIDSSSG---LILTARMLDHELVQHCTLKVRSI----- 2367
+ + ++ Y + S+ +F ++ ++G LI ++ +L + TL+++ I
Sbjct: 2454 AGIDGVILYSL----GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPK 2509
Query: 2368 -DSGFPSLSSEVLVHIYISDVNDNPPVF 2394
DS F S + V V++ S VF
Sbjct: 2510 SDSKFASCT--VFVNVSFSSEGTPLAVF 2535
Score = 516 bits (1330), Expect = e-145
Identities = 585/2199 (26%), Positives = 950/2199 (43%), Gaps = 245/2199 (11%)
Query: 73 IDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGS 132
++ S I YRI SGD G F + IRT+ L+ E Q +L V+
Sbjct: 405 LNSSEPIFYRISSGDLGGKFSIHPRLGT------IRTRKP----LDHETQPVVVLTVQAQ 454
Query: 133 VRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGE 192
+ + T+VNI V+D+ND P F T+ + I+++TP T++ A D D G NG
Sbjct: 455 LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 514
Query: 193 FYYYFKN-KVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAK 251
Y + + +F++ GV+ L+G L E+ L + A D+G+ + ++
Sbjct: 515 IRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV-----HPQAALLV 569
Query: 252 LYVHIERINEHAPT---IHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDP 308
L V IE+ EH+P+ H+V V S P ++ G +
Sbjct: 570 LTVVIEK-REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
Query: 309 LD--QFFLAKEGKWLNEYKIKERKQIDWESF-PYGYNLTLQAKDKGSPQKCSALKAVYIG 365
+D F + W I R+Q D+ES Y + + + G Q S V +
Sbjct: 629 VDSAMFGIRPYTGW-----IYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW 683
Query: 366 NPTRDTVPIRFEKEVYDVSISEFSPP----GVVVAIVKLSPEPIDVEYKLSPGEDAVYFK 421
+ D P F +V + + E P G + AI S + + Y L D +FK
Sbjct: 684 D-ENDNSP-TFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFK 739
Query: 422 INPRSG-----LIVT---------------------ARPLNTVKKEVYKLEVTN------ 449
+NP +G ++T A L ++ E+ + E+ N
Sbjct: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
Query: 450 -------------KEGDLKAQVTISI----EDANDHTPEFQQPL----YDAYVNESVPVG 488
G T+++ D ND+ P F Q L V E PV
Sbjct: 800 EHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVN 859
Query: 489 TSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVISTTEELDFESSPEIYRFIV 547
V TV A D D+G N +TYS++S + F I+ G I TT L ++ P YR V
Sbjct: 860 MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPS-YRMSV 918
Query: 548 RASDWG-SPYRHESEVNVTIRIGNVNDNSPLFE--KVACQGVISYDFPVGGHITAVSAI- 603
A+D G P + ++ VN+ + PL + + Q + P T + ++
Sbjct: 919 IATDQGVPPLQGQAVVNIQV--------IPLSKGRAIMSQNIRHLIIPENLKPTKIMSLI 970
Query: 604 -DIDELE-----LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATD 657
D L+ + + I++ ++ G F ++ +G L L K L ++ R+ TD
Sbjct: 971 KSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYE--TTSHYLFRVITTD 1028
Query: 658 -GENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFY 716
+NL+ ++ +S+ D
Sbjct: 1029 HSKNLSLSSTVFLSI------------------------------------------DVE 1046
Query: 717 SINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGF-NGKVLFTISDGNT-DSCF 774
N P F ++V+E++P+G + A D D F N ++ + I N + F
Sbjct: 1047 DQNDHSPSFQDEL-IVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPF 1105
Query: 775 NIDMETGQLKVLMPMDREHTDLYLLNITIYDLG-NPQKSSWRLLT--INVEDANDNSPVF 831
I G L + +DRE +L +T D N R LT I + D ND++P F
Sbjct: 1106 LIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF 1165
Query: 832 IQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLT--DTQQFAINSSTGIVYVA 889
I + ++ E +G+ + + A D D G NG+VTYS+L+ + F ++ S+G++
Sbjct: 1166 ISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT 1224
Query: 890 DQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDL 949
LD E K + L + A D + L S TL V + DVND +P F Y V E+
Sbjct: 1225 CPLDYEMKTQHILTVLALD--DGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQ 1282
Query: 950 PVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR-FEIDKASGAIRLSKELDYEKQQFYNL 1008
G + +E D D G+ ++++ ++ + FEI+ +G + + LD E Q+ + L
Sbjct: 1283 NPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTL 1342
Query: 1009 TVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAR 1068
V +D G P SLSS + + V D EN H P F + V EN V V A
Sbjct: 1343 RVLVRDGGFP-SLSSTTTILCTVED--ENDHAPEFIVSSYDIEVLENQE-PEVVYTVLAS 1398
Query: 1069 DEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL 1128
D D+G + ++Y I DG+ F+I++ SG ++ LDRE + ++ L + +D G P
Sbjct: 1399 DMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPR 1458
Query: 1129 YSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRIT 1188
S I + + V D ND++P Y V E++ V+ + A D D N + Y +T
Sbjct: 1459 SSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT 1518
Query: 1189 SGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG-PSPKQSTIWVVVQVLDE 1247
F I+ +G + TS LDRE +++H D + +T+ + V V D
Sbjct: 1519 D-EASGAFTIDPMSGTL-KTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDV 1576
Query: 1248 NDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFID 1307
NDN P + + + L + I R A D D GPN + +S + F ID
Sbjct: 1577 NDNDPVLEQNPFDVFLSPESPTNQTTVIVR--ADDLDLGPNGTVVFSFAE--TQSMFSID 1632
Query: 1308 PKTGMVSSRKQFTAGSYDI-LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPF 1366
TG + ++ ++ + I L +K D G P +++T L I + ++F
Sbjct: 1633 KYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHM----EGEDVKISFSHHL 1688
Query: 1367 YNFTVMES-DRVTEIVGVVSVQP--ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKP--L 1421
Y V E+ + T IV V + P + + I GN D G + + +P L
Sbjct: 1689 YKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFL 1748
Query: 1422 DAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQ 1481
D E R+ + V + A +V + + D NDN P F Q Y ++SE L + ++Q
Sbjct: 1749 DFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQ 1808
Query: 1482 IEATDRDEKHKLSYTVHSSIDSISMRK-FRIDPSTGVLYTAERLDHEAQDKHILNIMVRD 1540
+ ATD D L+ + SI S + + F+ID +GV+ T LD+E + L + D
Sbjct: 1809 VFATDLDS--GLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD 1866
Query: 1541 QEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAE 1600
+ P N + V V D ND++P F P + E + G V V+ D D N+
Sbjct: 1867 KGMPRLSNTTVIKVQVTDINDNAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVDL--NSA 1923
Query: 1601 LIYTI-EAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRI 1659
I++ + N G F I+ G++ + K D M ++ L I+++D S + A+V
Sbjct: 1924 FIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD--SVHYTEGALVVR 1981
Query: 1660 SVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI---SQSTLIYEVKDGDINGIFTI 1716
+ ++DN P F YQ V E++ +G SV+ +SA S + Y + F+I
Sbjct: 1982 VLDVNDNP-PVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSI 2038
Query: 1717 NPYSGVI-TTQKALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAPVFLFSQ 1773
+P +G I T L + S+ Q +++A++ + + V I I D N+ AP F
Sbjct: 2039 DPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKS 2098
Query: 1774 YSGSLSEAAPINSIVRSLDNSPLVIRATDADSNR-NALLVYQIVESTAKKFFTVDS---- 1828
Y+ SLSE A + S + + N D D R N + Y I+ ++ F V++
Sbjct: 2099 YNLSLSEDALVGSTLVTFSN-------IDHDWTRENTYVEYSIISGNSQNNFHVETKFFH 2151
Query: 1829 ------STGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPV 1882
G + + +LD E A + DSG P L+ S ++I+V DVNDNPP
Sbjct: 2152 SEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLS--STAVISIQVLDVNDNPPN 2209
Query: 1883 FTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVL-T 1940
F+ + T + T +G + VSA D D+ E+ Y+++ G+ HF ++ N+GVL
Sbjct: 2210 FSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYL 2269
Query: 1941 IKNNNLSK-DHYMLIVKVSDG--KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTN 1997
IK + K + L V+ SD K +S ++V + V + D F S +S + EN
Sbjct: 2270 IKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPI 2329
Query: 1998 ITKVAIVNAVGNRLNE--PLKYSILNP----------GNKFKIKSTSGVIQTTGVPFDRE 2045
+ + +NA+ L YSI++P + F I +G I + D E
Sbjct: 2330 SSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQI-LDYE 2388
Query: 2046 EQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQ 2105
Y L V+A + D A +VV V+IE I++ P+F Y+ + + LI +
Sbjct: 2389 NGNKYCLTVQAKDKGD--ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGR 2446
Query: 2106 VTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEA 2144
V A D D G +G + Y L F +N +GN+ L A
Sbjct: 2447 VEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRA 2485
Score = 516 bits (1329), Expect = e-145
Identities = 534/2001 (26%), Positives = 864/2001 (43%), Gaps = 167/2001 (8%)
Query: 1714 FTINPYSGVITTQKALDYERT-SSYQLIIQA--------TNMA----GMASNATVNIQIV 1760
F I+P+ G I + +D ER ++Y L+++A T++A G+++ A V + +
Sbjct: 109 FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLE 168
Query: 1761 DENDNAPVFLFSQYSGSLS-EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVEST 1819
D NDN PVF S Y S+S E P I+ L ATD DS + Y+++
Sbjct: 169 DVNDNHPVFNPSTYVTSISDETQPGTEIINVL--------ATDQDSGIYGTVAYELIPGN 220
Query: 1820 AKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS-----PQLTAESPVEVNIEVT 1874
FT+DS+TG + + + E ++ +F S P L VE + E
Sbjct: 221 VSSLFTIDSTTG----LYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAA 276
Query: 1875 DVNDNPPVFTQAVFETILLLPTYVGVEVLKVS--ATDPDSEVPPELTYSLMEGSLDHFLI 1932
+ +A + + LKV A D E +L + ++
Sbjct: 277 EKK------FEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAK------IL 324
Query: 1933 DSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSM---VTIMVKEAMDSGLHFTQSFYST 1989
LT+ ++L L+V DG + + VTI + + + F + Y+
Sbjct: 325 GEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 384
Query: 1990 SISENNTNITKVAIVNAVGNRLN--EPLKYSILNP--GNKFKIKSTSGVIQTTGVPFDRE 2045
+ E+ + + V A LN EP+ Y I + G KF I G I+T P D E
Sbjct: 385 LVYEDVPEDSPIGTVKA-REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK-PLDHE 442
Query: 2046 EQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQ 2105
Q + L V+A + V + + D+NDN P F+ + PGT +Y
Sbjct: 443 TQPVVVLTVQAQLG-SAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYL 501
Query: 2106 VTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGG 2164
A D+D G NG + Y + G F I+ G + L + + E +T+ A+D G
Sbjct: 502 ARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQR-ELTLTLRAEDQG 560
Query: 2165 KPSLSTSVELPITIVNKAMP---VFDKPFYTASVNEDIRMNTPILSINA--TSPE--GQG 2217
+ + L + I + F+ Y V+E + T +L A P+
Sbjct: 561 VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 620
Query: 2218 IIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLV 2277
+ Y + F I TG + + DYE T Y + A G V+ ++V
Sbjct: 621 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV 680
Query: 2278 N--DVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD------ 2329
D NDN P F + E+ + + ++ +ID DS N + Y ++ D
Sbjct: 681 RVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKM 740
Query: 2330 --------------------TYNSTDY-FHIDSSSGLILTARM-------------LDHE 2355
++ TD+ F D +L + LD E
Sbjct: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
Query: 2356 LVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLI----YESYVSELAPRGH 2411
H + V D G P ++ + V++ ++D+NDN P F Q + V E P
Sbjct: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNM 860
Query: 2412 FVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSV 2471
VT V A D D + + YS+ S + F +D+ +G I + P Y ++V
Sbjct: 861 LVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIA 920
Query: 2472 SD-GL--FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTY 2528
+D G+ A V+I+V+ + SQ+ + EN+ + ++++D Y
Sbjct: 921 TDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHY 980
Query: 2529 -GQISYAIINDFAKDRFLIDSN-GQVITTERLDRENPLEGDVSIFVRALDGG---GRTTF 2583
G++ ++I+ D F IDS+ G + ++ LD E + T F
Sbjct: 981 NGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVF 1040
Query: 2584 CTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGA--NSRITYSLYS 2641
++ V D+ND++P F SV +V G LV A D DDG+ NSRI Y Y
Sbjct: 1041 LSIDV--EDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD-DDGSFLNSRIQY--YI 1095
Query: 2642 EASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV---KHSLIPVYIHV 2698
E+ + I P G +VT ++ + V A D + V + + I +
Sbjct: 1096 ESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVI 1155
Query: 2699 LPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVI 2758
L P+F + + ED +GS V + V N+ F++
Sbjct: 1156 LDVNDHNPTFISFPNAH-VKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFML 1214
Query: 2759 EQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSS 2818
++ +G + LD E H + + + + + VLD+ND PVF+
Sbjct: 1215 DESSGLLTTTCPLDYEMKTQ-HILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHL 1273
Query: 2819 YDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTL 2878
Y+ + E G +T+V A+D D G N ++ + + P E F I+S+TG + T
Sbjct: 1274 YEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI----MPGASFELFEINSDTGEVVTT 1329
Query: 2879 KDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDP 2938
LD E FT V+ D G SLSST + V D ND+AP F Y V E+
Sbjct: 1330 TILDREIQEVFTLRVLVRDGGFP-SLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQE 1388
Query: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIY 2998
P V VL++ D D + NR V YHI GN F + + E + R LDRE+ +
Sbjct: 1389 PEVVYTVLAS-DMDAGN-NRAVEYHIIDGNTDECFTINEMSGE--LSTTRALDREQISNF 1444
Query: 2999 FLNITATDGLFVTQAMV---EVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKD 3055
L I +D ++ V +V V D ND+SP + Y + + ED ++L +SA D
Sbjct: 1445 TLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVD 1504
Query: 3056 ADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATD---GGGRF 3112
D G NG Y L + F +DP SG LKT LDRE ++ A A D G R
Sbjct: 1505 KDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
Query: 3113 CQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLAD 3172
I + + DVNDN PV + ++ + + T V+A D D+G N VV+S A+
Sbjct: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAE 1624
Query: 3173 SAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQS-PGQSLSSLTTVTITVLDIND 3231
+ +FSID +G I +Q E + + ++ TDQ P ++ + L + + D+
Sbjct: 1625 TQS-MFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLVIHMEGEDVKI 1682
Query: 3232 NPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTG 3291
+ F Y V E+ GT ++ V A + D + Y I SGNE G + K+G
Sbjct: 1683 S---FSHHLYKGLVTENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSG 1738
Query: 3292 GISVSE--VLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV 3349
++V E LD+E+ L+V A+ G A VA + + D NDN P F Q +Y A
Sbjct: 1739 QLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVL---IQDENDNSPCFEQSIYQAS 1795
Query: 3350 ISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERV 3409
+SE L VI + A D+DS NG I +SI++G+++ F +D + G++ K LD E
Sbjct: 1796 VSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELT 1855
Query: 3410 SGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLV 3469
S YSL+VQA D G+P +S+T + + ++D+NDN+P F P+ + +++ P G + +
Sbjct: 1856 SSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVS 1914
Query: 3470 VTDRDSFHNGPPFSFSILSGNEEEEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKDSGK 3528
V D D ++ FSF+ N +F +D + G++ E EY L +Q DS
Sbjct: 1915 VHDVD-LNSAFIFSFA-KESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS-- 1970
Query: 3529 PQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGV-IGKIHATDQDMYDVLTFA 3587
+ + VRV++ + + P + + VT+ + P G + + ATD + + +++
Sbjct: 1971 -VHYTEGALVVRVLDVNDN-PPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYR 2028
Query: 3588 LKSEQKSLFKVNSHDGKIIAL 3608
+ S K F ++ +G I +
Sbjct: 2029 ILSSSKE-FSIDPKNGTIFTI 2048
Score = 499 bits (1284), Expect = e-140
Identities = 491/1794 (27%), Positives = 813/1794 (45%), Gaps = 167/1794 (9%)
Query: 113 NSAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFSPTT----YSVTI 167
N L+RE + ++ + V + RG A V + V D+ND RP F V +
Sbjct: 793 NWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKV 852
Query: 168 AESTPLRTSVAQVTATDADIGSNGEFYYYF--KNKVDLFSVHPTSGVISLSGRLNYDEKN 225
E P+ V V A D D G+N E Y ++ D F + +G I + L+YD +
Sbjct: 853 LEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRP 912
Query: 226 RYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVV 285
Y + ++A D+G+ V + + + R H++ +P +L+ +++
Sbjct: 913 SYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLI--IPENLKPTKIMSLI 970
Query: 286 -TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLT 344
+ D L NG++ SIVA D F + + + K++D+E+ + Y
Sbjct: 971 KSSDHLQQHYNGKLH-FSIVADDKDGHFEIDS-----STGDLFLSKELDYETTSH-YLFR 1023
Query: 345 LQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP 404
+ D S+ + I ++ F+ E+ +S+ E P G +V + +
Sbjct: 1024 VITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDD 1083
Query: 405 -----IDVEYKL---SPGEDAVYFKINPRSGLIVTARPLN---------TVKKEVYKLEV 447
++Y + +PG + F I+P G +VT L+ TV + V
Sbjct: 1084 GSFLNSRIQYYIESHNPGTNP--FLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNV 1141
Query: 448 TNKE-GDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
T++ L AQ+ I D NDH P F +A+V E V VG+ V ++A D D+G NG
Sbjct: 1142 TDRRLRSLTAQIVIL--DVNDHNPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEGRNGK 1198
Query: 507 ITYSIASLN-LLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+TYSI S N + F++++ +G+++TT LD+E + + V A D G+P S+ +T
Sbjct: 1199 VTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQ-HILTVLALDDGTPALSSSQ-TLT 1256
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELGF 623
+ + +VND +P+F++ + + + G +T V A+D D ++++I+ G
Sbjct: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFEL 1316
Query: 624 FYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
F +N D+G + + ++ + I+ F LR+ DG S S
Sbjct: 1317 FEINSDTGEV-VTTTILDREIQE-VFTLRVLVRDG------------------GFPSLSS 1356
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYF-DKSFPSDVAVKEDLPVG 742
T + +ED N P F S+ +V ++ V
Sbjct: 1357 TTTILC-----------------TVEDE-------NDHAPEFIVSSYDIEVLENQEPEV- 1391
Query: 743 ANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNIT 802
+ + A D D+G N V + I DGNTD CF I+ +G+L +DRE + L I
Sbjct: 1392 --VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVIL 1449
Query: 803 IYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS 862
DLG+P +SS L + V DAND+SP F Y ++ E + +GT ++ + A DKD G
Sbjct: 1450 CSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGL 1509
Query: 863 NGEVTYSVLTD--TQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVV 920
NG+ Y LTD + F I+ +G + ++ LDRE+++ ++ ARD + G + +V+
Sbjct: 1510 NGQTEY-FLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVI 1568
Query: 921 TLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYN 980
+KV++ DVND P + + V + + P + D DLG G V +S +
Sbjct: 1569 -IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFA-ETQ 1626
Query: 981 GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPV-SLSSVSFVEVEVVDVNENLH 1039
F IDK +G I+ + E + L ++ D+G P + + + + +E DV +
Sbjct: 1627 SMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLVIHMEGEDVKIS-- 1683
Query: 1040 TPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGV 1099
F G V EN GTS++ V A DS +D ++YSI G+ G S+ +SG
Sbjct: 1684 ---FSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQD-SMKYSIFSGNEDGVLSLCSKSGQ 1739
Query: 1100 ITAAD--ILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVV 1157
+T + LD E L V A G + +V + ++D NDN+P + IY V
Sbjct: 1740 LTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSPCFEQSIYQASV 1796
Query: 1158 MENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQ 1217
E+ + VIQ+ A D DS N + Y I SGN + F I+ +G+ITT + LD E
Sbjct: 1797 SESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKA-ILDYELT 1855
Query: 1218 AEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKRGEPIY 1276
+ + L V TD G +T + VQV D NDN P F P + +I + G +
Sbjct: 1856 SSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEI----TEDSLPGVIVT 1911
Query: 1277 RAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDN 1334
D D S++ + N KF ID TG+V K F + L I+ D+
Sbjct: 1912 HVSVHDVDLNSAFIFSFA-KESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS 1970
Query: 1335 GRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQ--PANTP 1392
+ + ++ PP F + FY TV ES V V +S +N
Sbjct: 1971 VHYTEGALVVRVLDVNDNPP------VFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN 2024
Query: 1393 LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNV---AVTQVFIK 1449
+ + I+ + + + D + G I+ L + S VE +DG N A+T V I
Sbjct: 2025 ISYRILSSSKEFSIDPKNGT-IFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIG 2083
Query: 1450 VLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKF 1509
+ D N+ PEF+ +Y++++SED L + ++ D D + +Y +S I S F
Sbjct: 2084 IEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNF 2143
Query: 1510 RID----------PSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDA 1559
++ G L LD EA H L I+ D P + A + + V D
Sbjct: 2144 HVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDV 2203
Query: 1560 NDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPV 1619
ND+ P F++ Y V ES LGS + V+A D+D G +AE+IY I +GN F +E
Sbjct: 2204 NDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEEN 2263
Query: 1620 LGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSH-PKFIHKDYQA 1678
G++ + K D M +F L+++ +D S A+V +SV + DN H P+F+ +
Sbjct: 2264 TGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVFVSV-LDDNDHAPQFMFSSFSC 2321
Query: 1679 EVNENVDIGTSVILISAIS-----QSTLIYEVKDGDI--------NGIFTINPYSGVITT 1725
V EN+ I +++ I+A+ L Y + + +F I+P +G I
Sbjct: 2322 IVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHA 2381
Query: 1726 QKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPIN 1785
++ LDYE + Y L +QA + ++ V + I ++ P+F QY +L E
Sbjct: 2382 KQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDR 2441
Query: 1786 SIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANL 1839
++ + A+DAD+ + +++Y + T+ FF+V+ + G I I L
Sbjct: 2442 QLIGR-------VEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRAL 2486
Score = 486 bits (1252), Expect = e-136
Identities = 447/1665 (26%), Positives = 755/1665 (45%), Gaps = 96/1665 (5%)
Query: 2008 GNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVAR 2067
GN S + + FKI + +G I+TT + + + Y + V A+ + +
Sbjct: 873 GNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTI-LSYDYRPSYRMSVIATDQGVPPLQGQ 931
Query: 2068 VVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDK-DKGPNGEVTY--VLQ 2124
VV + + ++ + + + + +P ++ + + D + NG++ + V
Sbjct: 932 AVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVAD 991
Query: 2125 DDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKP-SLSTSVELPITIV--NK 2181
D GHFEI+ ++G++ L + + + ++ Y ++ D K SLS++V L I + N
Sbjct: 992 DKDGHFEIDSSTGDLFLSKELDYETTS-HYLFRVITTDHSKNLSLSSTVFLSIDVEDQND 1050
Query: 2182 AMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQ----GIIYIIIDGDP-FKQFNIDFD 2236
P F SV E++ + T + NA +G I Y I +P F I
Sbjct: 1051 HSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPS 1110
Query: 2237 TGVLKVVSPLDYEVTSAYKLTIRASDALTGAR----AEVTVDLLVNDVNDNPPIFDQPTY 2292
G L VS LD E LT+ ASD +T +++ DVND+ P F
Sbjct: 1111 FGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP- 1169
Query: 2293 NTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARML 2352
N + E +G+ V + + D D N V Y I+ N T F +D SSGL+ T L
Sbjct: 1170 NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMT--FMLDESSGLLTTTCPL 1227
Query: 2353 DHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHF 2412
D+E+ L V ++D G P+LSS + + + DVND PVF Q +YE+ V E G F
Sbjct: 1228 DYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEF 1287
Query: 2413 VTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVS 2472
VT V+A D DS +L++ I+ G F ++S +G + + + ++ +++L V V
Sbjct: 1288 VTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVR 1347
Query: 2473 DGLF---TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYG 2529
DG F +ST + V N ++P F S+Y EV EN V V A+D D G
Sbjct: 1348 DGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNR 1406
Query: 2530 QISYAIINDFAKDRFLI-DSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRV 2588
+ Y II+ + F I + +G++ TT LDRE + I L R++ ++V
Sbjct: 1407 AVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQV 1466
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVA 2648
V+D ND++P F T+ Y++SVR D G +V + A+D D+G N + Y L EAS
Sbjct: 1467 RVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEAS---- 1522
Query: 2649 DLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHS-LIPVYIHVLPPETFLPS 2707
IDP +G + T ++ + +F A D I S + + ++V P
Sbjct: 1523 GAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPV 1582
Query: 2708 FTQSQYSFTIAEDTAIGST-----VDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQET 2762
Q+ + ++ ++ T D L + P+ V FS + +F I++ T
Sbjct: 1583 LEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQ-------SMFSIDKYT 1635
Query: 2763 GTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTI 2822
G I+ + E P + + + + T + + ++ D K F Y +
Sbjct: 1636 GEIQFQQNPSSEYFPIW---LQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGL 1692
Query: 2823 IMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTL--KD 2880
+ E GT + V+A D + YS+ S ++ ++ S +G ++ K
Sbjct: 1693 VTENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNED----GVLSLCSKSGQLTVKEPKF 1747
Query: 2881 LDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPG 2940
LD E V+A G + V+V + D NDN+P F Q +Y+ +V ES
Sbjct: 1748 LDFEVRNEVQLIVLAESSGH----RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYN 1803
Query: 2941 EVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFL 3000
V + D D S +N + Y I GN F + + + K LD E Y L
Sbjct: 1804 AHVIQVFATDLD-SGLNGLIEYSILSGNQEEAFQIDALSG--VITTKAILDYELTSSYSL 1860
Query: 3001 NITATD-GL--FVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDAD 3057
+ ATD G+ +++V V+D+NDN+P + + +P I+ VS D D
Sbjct: 1861 IVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVSVHDVD 1919
Query: 3058 IGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNI 3117
+ S ++ + ++F +D +G + + LD E + Y L+ + +D + + +
Sbjct: 1920 LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SVHYTEGAL 1978
Query: 3118 HLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGV 3177
+ + DVNDNPPVFS D Y V E+ + + A D+ N + Y + S+
Sbjct: 1979 VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSAT--DLESNENISYRIL-SSSKE 2035
Query: 3178 FSIDSSSGIIILEQP-LDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVF 3236
FSID +G I P L + S+ V A+D L +LT V I + D+N+ P F
Sbjct: 2036 FSIDPKNGTIFTISPVLLLDTISTTQFLVEASD-GGNPDLRALTLVEIGIEDMNNYAPEF 2094
Query: 3237 ERRDYLVTVPEDTSPGTQVLAVFATSKD-IGTNAEITYLIRSGNEQGKFKINPK------ 3289
+ Y +++ ED G+ ++ D N + Y I SGN Q F + K
Sbjct: 2095 TVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEY 2154
Query: 3290 ----TGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDV 3345
G + + LD E LV+ A D G P LS+ A ++I + DVNDNPP FS
Sbjct: 2155 PYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLS 2214
Query: 3346 YSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLD 3405
Y + E +G + ++ A D D+ + +I ++I++G+ F ++ G++ + K LD
Sbjct: 2215 YHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLD 2274
Query: 3406 RERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSI 3465
E+++ ++L VQA D+ S A V + + D ND++P F ++++ ++ EN P+ ++I
Sbjct: 2275 YEKMTKFTLTVQASDAE-KKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTI 2333
Query: 3466 LQLVVTDRDSFHNGPPFSFSILS--------GNEEEEFVLDP-HGILRSAVVFQHTESLE 3516
+ D D+ G ++SI+S + + F++DP G + + + + +
Sbjct: 2334 CSINALDFDAGPYG-ELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNK 2392
Query: 3517 YVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHAT 3576
Y L VQAKD G ++ + I+E +P + F E + +IG++ A+
Sbjct: 2393 YCLTVQAKDKGDATASLVVWVDIEGIDE--FEPIFTQDQYFFTLPEKNKDRQLIGRVEAS 2450
Query: 3577 DQD--MYDVLTFALKSEQKSLFKVNSHDGKIIALGGLDSGKYVLN 3619
D D + V+ ++L F VN +G I + L K LN
Sbjct: 2451 DADAGIDGVILYSL-GTSSPFFSVNKTNGNIYLIRALPLIKSQLN 2494
Score = 424 bits (1091), Expect = e-118
Identities = 474/1843 (25%), Positives = 774/1843 (41%), Gaps = 168/1843 (9%)
Query: 1900 VEVLKVSATDPDSEVPPELTYSLMEGSLDH-----FLIDSNSGVLTIKNN-NLSKD--HY 1951
V+ +V+A+D DS + + YSL +G L + F ID + G + + + + +D Y
Sbjct: 74 VKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATY 133
Query: 1952 MLIVKVSDGK-------------FYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNI 1998
L+V+ DG + + V + +++ D+ F S Y TSIS+
Sbjct: 134 DLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPG 193
Query: 1999 TKVAIVNAV--GNRLNEPLKYSILNPGN---KFKIKSTSG-------VIQTTGVPFDREE 2046
T++ V A + + + Y ++ PGN F I ST+G ++ D+E
Sbjct: 194 TEIINVLATDQDSGIYGTVAYELI-PGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEV 252
Query: 2047 QELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQV 2106
E+ + R + E F G + ++V E
Sbjct: 253 MNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDE-------- 304
Query: 2107 TAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGG-- 2164
A D L G +I S L + + + A+DGG
Sbjct: 305 -AASADGEAAARYVANLAKILGE--------GIIYLTLPLSHLESTTLSLMVSAQDGGGL 355
Query: 2165 KPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP--EGQGIIYII 2222
++ V + I A F++P YT V ED+ ++PI ++ A P + I Y I
Sbjct: 356 TAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRI 415
Query: 2223 IDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVND 2282
GD +F+I G ++ PLD+E LT++A A + V++ V DVND
Sbjct: 416 SSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVND 475
Query: 2283 NPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSS 2342
N P F + + +S+ + GT + + D DS N ++ Y I F ID +
Sbjct: 476 NHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP---QPGVFAIDRA 532
Query: 2343 SGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPP-VFNQLIYES 2401
G++ L + TL +R+ D G ++ +++ + I +P F L+Y+
Sbjct: 533 LGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQV 592
Query: 2402 YVSE-LAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQR 2460
VSE L+P + L YS+ D F + +G I L
Sbjct: 593 EVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYE 652
Query: 2461 MEPLYSLNVSV---SDGLFTS-TAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI 2516
Y+ V DG + + V +RV N SP F +V E+ +
Sbjct: 653 STQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIG 712
Query: 2517 HVRATDGDPGTYGQISYAIIND----------------------------------FAKD 2542
+ A D D G GQ+ Y +++D F+ D
Sbjct: 713 KITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSD 772
Query: 2543 R---FLIDS------NGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDE 2593
F++ S G++I LDRE+ ++++ V R V V V D
Sbjct: 773 ELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDI 832
Query: 2594 NDNAPQFMTVEYRASVRADVGRGH----LVTQVQAIDPDDGANSRITYSLYSEASVSVAD 2649
NDN P F + V G LVT V A DPD+G N+ +TYS+ SE S +D
Sbjct: 833 NDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDS---SD 889
Query: 2650 LLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFT 2709
+ID +NG + T + V A D G+P V I V+P +
Sbjct: 890 HFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMS 949
Query: 2710 QSQYSFTIAED---TAIGSTV---DTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETG 2763
Q+ I E+ T I S + D L+ + + FS V ++K G F I+ TG
Sbjct: 950 QNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIV-----ADDKDGHFEIDSSTG 1004
Query: 2764 TIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTII 2823
+ L K LD ET+ + F+V T + + TV + I V D ND+ P F+ +
Sbjct: 1005 DLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISV 1064
Query: 2824 MEGMPVGTKLTQVRAIDMDWG-ANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLD 2882
E +P+GT + A D D N ++ Y + S + F I + G + T+ LD
Sbjct: 1065 EENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPG---TNPFLIHPSFGTLVTVSRLD 1121
Query: 2883 HETDPTFTFSVVASDLGEAFSLSSTALVS----VRVTDINDNAPVFAQEVYRGNVKESDP 2938
E+ PT +V ASD +A +++ L S + + D+ND+ P F +VKE
Sbjct: 1122 RESIPTVILTVTASD--QAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVT 1178
Query: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIY 2998
G +V ++ D D N +V+Y I GN F L +S + PLD E + +
Sbjct: 1179 VGSLVHHITAHDPDEGR-NGKVTYSILSGNENMTFMLD--ESSGLLTTTCPLDYEMKTQH 1235
Query: 2999 FLNITATDG---LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKD 3055
L + A D + + V+V DVND +PV Q Y A + E+ + + +V A D
Sbjct: 1236 ILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALD 1295
Query: 3056 ADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQ 3114
D G N +++ + + E F ++ ++GE+ T +LDRE V++L DGG
Sbjct: 1296 RDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLS 1355
Query: 3115 SNIHLI--LEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLAD 3172
S ++ +ED ND+ P F Y+ V EN + + T V A D D G NR V Y + D
Sbjct: 1356 STTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYT-VLASDMDAGNNRAVEYHIID 1414
Query: 3173 -SAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDIND 3231
+ F+I+ SG + + LDREQ S++ + + +D SS+ + + VLD ND
Sbjct: 1415 GNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLG-DPPRSSVIHLQVRVLDAND 1473
Query: 3232 NPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTG 3291
+ P F Y +V ED GT VL + A KD G N + Y + + G F I+P +G
Sbjct: 1474 HSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL-TDEASGAFTIDPMSG 1532
Query: 3292 GISVSEVLDYELCKRFYLVVEAKDGGTP-ALSAVATVNINLTDVNDNPPKFSQDVYSAVI 3350
+ S LD E + A+D + S + + +TDVNDN P Q+ + +
Sbjct: 1533 TLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFL 1592
Query: 3351 SEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVS 3410
S ++ + +++ A+D+D PNG + FS + + F++D G ++ ++ E
Sbjct: 1593 SPESPTNQTTVIVRADDLDLGPNGTVVFSF--AETQSMFSIDKYTGEIQFQQNPSSEYFP 1650
Query: 3411 GYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVV 3470
+ L ++ D GIPA ++T + I + + D F+ Y ++ EN GTSI+ +
Sbjct: 1651 IW-LQLKVTDQGIPARTTTGLLVIHM-EGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA 1708
Query: 3471 TDRDSFHNGPPFSFSILSGNEEEEFVLDPHG---ILRSAVVFQHTESLEYVLCVQAKDSG 3527
DS + +SI SGNE+ L ++ E L V A+ SG
Sbjct: 1709 FAPDSIQDS--MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG 1766
Query: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQD--MYDVLT 3585
++ + V + +E+ + P E + ++ ATD D + ++
Sbjct: 1767 ---HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIE 1823
Query: 3586 FA-LKSEQKSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSD 3624
++ L Q+ F++++ G I LD + Y L V +D
Sbjct: 1824 YSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD 1866
Score = 410 bits (1053), Expect = e-113
Identities = 474/1796 (26%), Positives = 768/1796 (42%), Gaps = 224/1796 (12%)
Query: 78 DIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRG-E 136
++ Y + S D FK D IRT + IL+ + + +Y + V + +G
Sbjct: 877 EVTYSVSSEDSSDHFKI------DANNGEIRT----TTILSYDYRPSYRMSVIATDQGVP 926
Query: 137 DLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATD-ADIGSNGEFYY 195
L+ VNIQV+ ++ R + S + I E+ ++ + ++D NG+ ++
Sbjct: 927 PLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHF 986
Query: 196 YF--KNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLY 253
+K F + ++G + LS L+Y+ + Y ++ D L +SST L
Sbjct: 987 SIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNL----SLSSTVFLS 1042
Query: 254 VHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFF 313
+ +E N+H+P+ V E P +V V + D + S Q++
Sbjct: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRI--------QYY 1094
Query: 314 LAKEGKWLNEYKIKER-------KQIDWESFPYGYNLTLQAKDKG---SPQKCSALKAVY 363
+ N + I ++D ES P LT+ A D+ + ++ +L A
Sbjct: 1095 IESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI-LTVTASDQAVNVTDRRLRSLTAQI 1153
Query: 364 I------GNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPI---DVEYKLSPG 414
+ NPT + P KE DV++ +V I P+ V Y + G
Sbjct: 1154 VILDVNDHNPTFISFPNAHVKE--DVTVGS-----LVHHITAHDPDEGRNGKVTYSILSG 1206
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKA-----QVTISIEDANDHT 469
+ + F ++ SGL+ T PL+ K + L V + A +T+++ D ND
Sbjct: 1207 NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEA 1266
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI---ASLNLLPFVINQFTG 526
P F+Q LY+A V E+ G V V A D+D G N + + I AS L F IN TG
Sbjct: 1267 PVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFEL--FEINSDTG 1324
Query: 527 VISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGV 586
+ TT LD E E++ V D G P S + + + ND++P F V
Sbjct: 1325 EVVTTTILDREIQ-EVFTLRVLVRDGGFPSL-SSTTTILCTVEDENDHAPEFI------V 1376
Query: 587 ISYDF-------PVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSL 639
SYD P + S +D V+Y II GN F +N SG L ++L
Sbjct: 1377 SSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRAL 1436
Query: 640 TNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIK 699
I NF L I +D L DP SV+H +V RV
Sbjct: 1437 DREQI--SNFTLVILCSD---LGDPP--RSSVIHLQV----------RV----------- 1468
Query: 700 AKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNG 759
L+ D F ++ Y+ S V+ED VG +L + A D D G NG
Sbjct: 1469 ------LDANDHSPSFPTL-----YYQSS------VREDAEVGTVVLVLSAVDKDEGLNG 1511
Query: 760 KVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLG-NPQKSSWRLLT 818
+ + ++D F ID +G LK +DRE + + D +S+ ++
Sbjct: 1512 QTEYFLTD-EASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIK 1570
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFA 878
+ V D NDN PV Q+ + V + S + V A D DLG NG V +S F+
Sbjct: 1571 VYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFS 1630
Query: 879 INSSTGIVYVADQLDRESKANYS---LKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPA 935
I+ TG + Q + + Y L+++ D+ + ++ + + +DV +
Sbjct: 1631 IDKYTGEI----QFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDV---KIS 1683
Query: 936 FIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASG--AI 992
F Y V E+ GT I ++ PD + ++YS+ + + +G + SG +
Sbjct: 1684 FSHHLYKGLVTENCEAGTSIVTVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTV 1742
Query: 993 RLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
+ K LD+E + L V A+ G ++ +V V+ +EN ++P F SV
Sbjct: 1743 KEPKFLDFEVRNEVQLIVLAESSGHR------AYCKVAVLIQDENDNSPCFEQSIYQASV 1796
Query: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMG 1112
E+ V+QV A D DSG +G I+YSI G+ F ID SGVIT ILD E
Sbjct: 1797 SESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTS 1856
Query: 1113 SYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAP--LTSEPIYYPVVMENSPKDVSVIQI 1170
SY L V ATD+G+ L +T + ++V D+NDNAP L SE + + E+S V V +
Sbjct: 1857 SYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAV---EITEDSLPGVIVTHV 1913
Query: 1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG 1230
D D +S ++ S NP FAI+ TG++ + LD E+ E+ L + ++D
Sbjct: 1914 SVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLV-KTLDFEEMTEYELLIQISD-- 1969
Query: 1231 PSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAE 1290
S + +VV+VLD NDN P F + YQ+ +PE G + A D + N
Sbjct: 1970 -SVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE--SIPVGYSVLTLSATDLES--NEN 2024
Query: 1291 ISYSIVDGNDDGKFFIDPKTG---MVSSRKQFTAGSYDILTIKAVDNGRP--QKSSTARL 1345
ISY I+ + + F IDPK G +S S ++A D G P + + +
Sbjct: 2025 ISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEI 2082
Query: 1346 HIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVS-----VQPANTPLWFDIVGG 1400
IE + P F YN ++ E V + S NT + + I+ G
Sbjct: 2083 GIEDMNNYAPE-----FTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISG 2137
Query: 1401 NFDSAFDAE----------KGVGTIVIAKPLDAEQRSIYNMSVEVTDG-----TNVAVTQ 1445
N + F E K VG +V+ LD E + + + + +D ++ AV
Sbjct: 2138 NSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV-- 2195
Query: 1446 VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSIS 1505
+ I+VLD NDN P FS +Y + E + I + A DRD + +++ I
Sbjct: 2196 ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSH-AEIIYNIISGNE 2254
Query: 1506 MRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPY 1565
F ++ +TGVLY + LD+E K L + D E + + A V V+V D NDH+P
Sbjct: 2255 KGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKH-FSFAVVFVSVLDDNDHAPQ 2313
Query: 1566 FTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEA--------GNTGNMFKIE 1617
F + V E+ + S + + ALD D G EL Y+I + ++F I+
Sbjct: 2314 FMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLID 2373
Query: 1618 PVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQ 1677
P+ G I + D ++ L+++ D+G +A+ +V + + D P F Y
Sbjct: 2374 PLTGDIHAKQILDYENGNKYCLTVQAKDKGD--ATASLVVWVDIEGIDEFEPIFTQDQYF 2431
Query: 1678 AEVNE--------------NVDIGTSVILISAISQSTLIYEVKDGDINGIFTINPYSGVI 1723
+ E + D G +++ ++ S+ + V + N I+ I +
Sbjct: 2432 FTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGN-IYLIR---ALP 2487
Query: 1724 TTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLF-SQYSGSL 1778
+ L+ E T ++I + ++ TV + + ++ P+ +F S +S SL
Sbjct: 2488 LIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISL 2543
Score = 319 bits (817), Expect = 5e-86
Identities = 344/1318 (26%), Positives = 545/1318 (41%), Gaps = 147/1318 (11%)
Query: 2414 TCVQASDADSSDFDRLEYSILSG----NDRTSFLMDSKSGVITLSNHRKQRMEPL-YSLN 2468
T V ASDADS + +EYS+ G +F +D G I +S + +P Y L
Sbjct: 77 TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL 136
Query: 2469 VSVSDGL-------------FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKV 2515
V DG ++ A V + + N P F+ STYV + + GT++
Sbjct: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
Query: 2516 IHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNG-------QVITTERLDRENPLEGDV 2568
I+V ATD D G YG ++Y +I F IDS ++++ + + +
Sbjct: 197 INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSL 256
Query: 2569 SIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGH---LVTQVQAI 2625
+F+ L + V+ ++ A + R GR H L Q +A
Sbjct: 257 EMFLPLLRHFKK----------VERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAA 306
Query: 2626 DPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGI 2685
D A +R VA+L +I G + + L++T LS V A DGG
Sbjct: 307 SADGEAAARY-----------VANLAKI-LGEGIIYLTLPLSHLESTTLSLMVSAQDGGG 354
Query: 2686 PVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLR----ILPSQNVWFS 2741
V IH+ F + +Y+F + ED S + T++ + S+ +++
Sbjct: 355 LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYR 414
Query: 2742 TVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVD 2801
+G+ GG F I GTI+ K LD ET P V A L + +V+
Sbjct: 415 ISSGD-----LGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA--QLGSAPACSSTEVN 467
Query: 2802 IKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEK 2861
I V+D+NDN P F +S + I + P GT L RA D D G NG + YS+ S QP
Sbjct: 468 ITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS-PQP-- 524
Query: 2862 VMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNA 2921
F ID G + L T ++ A D G + LV V + +++
Sbjct: 525 --GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG--VHPQAALLVLTVVIEKREHS 580
Query: 2922 P--VFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQ 2979
P F VY+ V ES P + + Y + F G+
Sbjct: 581 PSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMF--GIRP 638
Query: 2980 SEWKVYVKRPLDREEQDIYFLNITA---TDG-LFVTQAMVEVSVSDVNDNSPV-CDQVAY 3034
+Y++R D E Y + A DG L V V V D NDNSP V +
Sbjct: 639 YTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLF 698
Query: 3035 TALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGN--------------------- 3073
+ +P +I K++A D D G NG + Y L G
Sbjct: 699 LKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWAD 757
Query: 3074 ----------------------SEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGG- 3110
F + GEL LDRE + + TD G
Sbjct: 758 GAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSP 817
Query: 3111 -RFCQSNIHLILEDVNDNPPVF----SSDHYNTCVYENTATKALLTRVQAVDPDIGINRK 3165
R +++ + D+NDN P F + V E L+T V A DPD G N +
Sbjct: 818 PRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAE 877
Query: 3166 VVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTI 3224
V YS+ ++ + F ID+++G I L + + SY +SV ATDQ L V I
Sbjct: 878 VTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGV-PPLQGQAVVNI 936
Query: 3225 TVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGT--NAEITYLIRSGNEQG 3282
V+ ++ + + + +PE+ P T+++++ +S + N ++ + I + ++ G
Sbjct: 937 QVIPLSKGRAIMSQNIRHLIIPENLKP-TKIMSLIKSSDHLQQHYNGKLHFSIVADDKDG 995
Query: 3283 KFKINPKTGGISVSEVLDYELCKRF-YLVVEAKDGGTPALSAVATVNINLTDVNDNPPKF 3341
F+I+ TG + +S+ LDYE + + V+ +LS+ ++I++ D ND+ P F
Sbjct: 996 HFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSF 1055
Query: 3342 SQDVYSAVISEDALVGDSVILLIAEDVD-SQPNGQIHFSI-VNGDRDNEFTVDPVLGLVK 3399
++ + E+ +G V + A+D D S N +I + I + N F + P G +
Sbjct: 1056 QDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLV 1115
Query: 3400 VKKKLDRERVSGYSLLVQAVDSGIPAMS---STATVNIDISDVNDNSPVFTPANYTAVIQ 3456
+LDRE + L V A D + + T I I DVND++P F + A ++
Sbjct: 1116 TVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVK 1174
Query: 3457 ENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLD-PHGILRSAVVFQHTESL 3515
E+ VG+ + + D D NG ++SILSGNE F+LD G+L + +
Sbjct: 1175 EDVTVGSLVHHITAHDPDEGRNG-KVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKT 1233
Query: 3516 EYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHA 3575
+++L V A D G P S + V V++ + P E+ PG + ++ A
Sbjct: 1234 QHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEA 1293
Query: 3576 TDQD--MYDVLTF-ALKSEQKSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDGRF 3627
D+D + L F + LF++NS G+++ LD + L V V DG F
Sbjct: 1294 LDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGF 1351
Score = 251 bits (642), Expect = 9e-66
Identities = 315/1211 (26%), Positives = 491/1211 (40%), Gaps = 153/1211 (12%)
Query: 2506 RENVAAGTKVIHVRATDGDPGTYGQISYAIINDF----AKDRFLIDSN-GQVITTERLDR 2560
+E A K V A+D D G YG I Y++ + F A F ID + GQ+ ++ +DR
Sbjct: 67 QEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDR 126
Query: 2561 ENPLEGDVSIFVRALDG------------GGRTTFCTVRVIVVDENDNAPQFMTVEYRAS 2608
E + V A DG GG + VRV + D NDN P F Y S
Sbjct: 127 ERD-PATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTS 185
Query: 2609 VRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGW------MVT 2662
+ + G + V A D D G + Y L +V+ L ID G +++
Sbjct: 186 ISDETQPGTEIINVLATDQDSGIYGTVAYELIPG---NVSSLFTIDSTTGLYSPEVEILS 242
Query: 2663 KGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLP---SFTQSQYSFTIAE 2719
NF+ K + S E FLP F + + AE
Sbjct: 243 AVNFSADKEVMNSL-------------------------EMFLPLLRHFKKVERDEEAAE 277
Query: 2720 DTAIGSTVDTLRILPSQNVWF-------STVNGERPENNKGGIFVIEQETGTIKLDKRLD 2772
S +R +++ + ++ +GE + I E G I L L
Sbjct: 278 KKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGE-GIIYLTLPLS 336
Query: 2773 RETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTK 2832
S V+A + V DV I + FE Y ++ E +P +
Sbjct: 337 HLESTTLSLMVSAQ-DGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSP 395
Query: 2833 LTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFS 2892
+ V+A + ++ + Y + S K F+I G I T K LDHET P +
Sbjct: 396 IGTVKARE-PLNSSEPIFYRISSGDLGGK----FSIHPRLGTIRTRKPLDHETQPVVVLT 450
Query: 2893 VVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRD 2952
V A LG A + SST V++ V D+NDN P F + + ++ PPG + + DRD
Sbjct: 451 VQA-QLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRD 508
Query: 2953 TSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ 3012
S N + Y I P G FA+ ++ +++ L EQ L + A D Q
Sbjct: 509 -SGRNGLIRYSIASPQP-GVFAID--RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQ 564
Query: 3013 A--MVEVSVSDVNDNSP--VCDQVAYTALLPEDIPSNKIILKVSAKD-ADIGSNGYIRYS 3067
A +V V + ++SP + + Y + E + +L+ A + +RYS
Sbjct: 565 AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYS 624
Query: 3068 LYGSGNSEFF-LDPESGELKTLALLDRERIPVYSLMAKA---TDGGGRFCQSNIHLILED 3123
L S +S F + P +G + D E Y+ A DG + + + + + D
Sbjct: 625 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWD 684
Query: 3124 VNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSL------------- 3170
NDN P F D V E+ + ++ ++ A+D D G N +++Y L
Sbjct: 685 ENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
Query: 3171 -----------ADSAGG------VFSIDS-------------SSGIIILEQPLDREQQSS 3200
AD A FS D G +I LDRE +
Sbjct: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
Query: 3201 YNISVRATDQ-SPGQSLSSLTTVTITVLDINDNPPVFER----RDYLVTVPEDTSPGTQV 3255
+ ++V TD+ SP ++ + V++T DINDN P F + ++ V V E V
Sbjct: 805 HEMTVLVTDRGSPPRNATMAVYVSVT--DINDNRPFFPQCLPGKELHVKVLEGQPVNMLV 862
Query: 3256 LAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKD 3315
VFA D G NAE+TY + S + FKI+ G I + +L Y+ + + V A D
Sbjct: 863 TTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATD 922
Query: 3316 GGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAED-VDSQPNG 3374
G P L A VNI + ++ SQ++ +I E+ + L+ + D + NG
Sbjct: 923 QGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNG 982
Query: 3375 QIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVD-SGIPAMSSTATVN 3433
++HFSIV D+D F +D G + + K+LD E S Y V D S ++SST ++
Sbjct: 983 KLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLS 1042
Query: 3434 IDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNE-E 3492
ID+ D ND+SP F ++EN P+GT + D D + I S N
Sbjct: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGT 1102
Query: 3493 EEFVLDP-HGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVR-------VIEE 3544
F++ P G L + +L V A D Q V+ T R+R +++
Sbjct: 1103 NPFLIHPSFGTLVTVSRLDRESIPTVILTVTASD----QAVNVTDRRLRSLTAQIVILDV 1158
Query: 3545 STHKPTAIPLEIFIVTMEDDFPGGVIGKI--HATDQDMYDVLTFALKSEQKSL-FKVNSH 3601
+ H PT I V ED G ++ I H D+ +T+++ S +++ F ++
Sbjct: 1159 NDHNPTFISFPNAHV-KEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDES 1217
Query: 3602 DGKIIALGGLD 3612
G + LD
Sbjct: 1218 SGLLTTTCPLD 1228
Score = 140 bits (353), Expect = 3e-32
Identities = 195/847 (23%), Positives = 360/847 (42%), Gaps = 133/847 (15%)
Query: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLID--LSWDIKYRIVSGDEEGFFKAEEVIIA 100
F SIY A+V E+ +V ++ T +D L+ I+Y I+SG++E F+ + +
Sbjct: 1787 FEQSIYQASVSESQLYNAHV---IQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGV 1843
Query: 101 DFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFS 159
I TK AIL+ E+ +Y LIV+ + +G L T + +QV D+ND P F
Sbjct: 1844 ------ITTK----AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFL 1893
Query: 160 PTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF---KNKVDLFSVHPTSGVISLS 216
P+ +V I E + V V+ D D+ N F + F N F++ +GV+ L
Sbjct: 1894 PSE-AVEITEDSLPGVIVTHVSVHDVDL--NSAFIFSFAKESNPGTKFAIDQNTGVVVLV 1950
Query: 217 GRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSL 276
L+++E Y+L I D ++ G L V + +N++ P +
Sbjct: 1951 KTLDFEEMTEYELLIQISD---SVHYTEGA-----LVVRVLDVNDNPPVFSQDFYQVTVP 2002
Query: 277 EKEPT-YAVVTVDDLDDGANGEIESVSIVAGDPLDQFFL-AKEGKWLNEYKIKERKQIDW 334
E P Y+V+T+ D +N E++S +F + K G + I
Sbjct: 2003 ESIPVGYSVLTLSATDLESN---ENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTIST 2059
Query: 335 ESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVV 394
F ++A D G+P AL V IG + F + Y++S+SE + G
Sbjct: 2060 TQF------LVEASDGGNPD-LRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
Query: 395 VAIVK-----LSPEPIDVEYKLSPGEDAVYFKINPRS----------GLIVTARPLNTVK 439
+ + E VEY + G F + + G +V L+
Sbjct: 2113 LVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREA 2172
Query: 440 KEVYKLEVTNKEGDLK-----AQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTV 494
++L + + A ++I + D ND+ P F Y +V ES P+G+ + V
Sbjct: 2173 SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVV 2232
Query: 495 SASDKDKGENGYITYSIASLNLL-PFVINQFTGVISTTEELDFESSPEIYRFIVRASDWG 553
SA+D+D G + I Y+I S N F + + TGV+ + LD+E + + V+ASD
Sbjct: 2233 SANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTK-FTLTVQASD-- 2289
Query: 554 SPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDID--ELELV 611
+ +H S V + + + ND++P F + ++ + P+ I +++A+D D +
Sbjct: 2290 AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGEL 2349
Query: 612 KYKIIS--------GNELGFFYLNPDSGVLQLKKSLTNSGIKNGN-FALRITATDGENLA 662
Y I+S + F ++P +G + K+ L +NGN + L + A D +
Sbjct: 2350 TYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQIL---DYENGNKYCLTVQAKDKGDAT 2406
Query: 663 DPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQG 722
+ + + + +G +F I Q
Sbjct: 2407 ASLVVWVDI--------------------------------------EGIDEFEPIFTQD 2428
Query: 723 PYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQ 782
YF F K+ +G +++A DAD+G +G +L+++ G + F+++ G
Sbjct: 2429 QYF---FTLPEKNKDRQLIG----RVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGN 2479
Query: 783 LKVL--MPMDREH---TDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFI-QDSY 836
+ ++ +P+ + D + I + + K + + +NV +++ +P+ + S+
Sbjct: 2480 IYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSF 2539
Query: 837 SVNILES 843
S++++ S
Sbjct: 2540 SISLVVS 2546
Score = 101 bits (252), Expect = 1e-20
Identities = 117/455 (25%), Positives = 203/455 (44%), Gaps = 46/455 (10%)
Query: 24 KLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWD----- 78
+ L V G+ FT YN ++ E++ + + + S ID W
Sbjct: 2075 RALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSN-----IDHDWTRENTY 2129
Query: 79 IKYRIVSGDEEGFFKAEEVII-ADFCFLRIRTKGGNSAILN---REIQDNYLLIVKGSVR 134
++Y I+SG+ + F E +++ + ++ G +L+ RE ++ L++ S
Sbjct: 2130 VEYSIISGNSQNNFHVETKFFHSEYPYKQV----GYLVLLHSLDREASASHELVILASDS 2185
Query: 135 G-EDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEF 193
G L + ++IQVLD+ND P FS +Y + ESTPL + + V+A D D GS+ E
Sbjct: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
Query: 194 YYYF--KNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAK 251
Y N+ F + +GV+ L L+Y++ ++ L + A D K + S A
Sbjct: 2246 IYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHF------SFAV 2299
Query: 252 LYVHIERINEHAPTIHVVTH---VPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDP 308
++V + N+HAP + VP +L T + D D G GE+ + SIV+
Sbjct: 2300 VFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGEL-TYSIVSPCF 2358
Query: 309 LDQFFLAKEGKWLNEY---KIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIG 365
L +L + I ++ +D+E+ Y LT+QAKDKG +A V++
Sbjct: 2359 LTHGMSYDHDLFLIDPLTGDIHAKQILDYEN-GNKYCLTVQAKDKGD---ATASLVVWVD 2414
Query: 366 NPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP--IDVEYKLSPGEDAVYFKIN 423
D F ++ Y ++ E + ++ V+ S ID S G + +F +N
Sbjct: 2415 IEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVN 2474
Query: 424 PRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQV 458
+G I R L +K ++ NKE L+ ++
Sbjct: 2475 KTNGNIYLIRALPLIKSQL------NKEDTLEMKI 2503
Score = 66.6 bits (161), Expect = 5e-10
Identities = 52/173 (30%), Positives = 76/173 (43%), Gaps = 15/173 (8%)
Query: 1047 AVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDG----SGLGRFSIDDESGVITA 1102
A+V +E + +VTA D DSG G I+YS+ DG F ID G I
Sbjct: 61 AIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 120
Query: 1103 ADILDRET-MGSYWLTVYATDRGVVP----------LYSTIEVYIEVEDVNDNAPLTSEP 1151
+ +DRE +Y L V A D L + V +++EDVNDN P+ +
Sbjct: 121 SQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPS 180
Query: 1152 IYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGL 1204
Y + + + +I + A D DS + Y + GN + F I+ TGL
Sbjct: 181 TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233
Score = 50.8 bits (120), Expect = 3e-05
Identities = 47/171 (27%), Positives = 68/171 (39%), Gaps = 18/171 (10%)
Query: 1159 ENSPKDVSVIQIQAEDPDSSSNEKLTYRITSG----NPQNFFAINIKTGLITTTSRKLDR 1214
E + K V ++ A D DS + Y + G F I+ G I S+ +DR
Sbjct: 68 EENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV-SQDIDR 126
Query: 1215 EQQ-AEHFLEVTVTDGGPSPK----------QSTIWVVVQVLDENDNKPQFPEKVYQIKL 1263
E+ A + L V DG + +V V + D NDN P F Y +
Sbjct: 127 ERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI 186
Query: 1264 PERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVS 1314
D + G I A D+D G ++Y ++ GN F ID TG+ S
Sbjct: 187 S--DETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS 235
Score = 35.0 bits (79), Expect = 1.7
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 15/135 (11%)
Query: 179 QVTATDADIGSNGEFYYYFKNKV------DLFSVHPTSGVISLSGRLNYD-EKNRYDLEI 231
+VTA+DAD G G Y + F + P G I +S ++ + + YDL +
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
Query: 232 LAVDRGMKLYGN-----NGVSSTAKLYVHIERINEHAPTIHVVTHV-PFSLEKEPTYAVV 285
A D + + G+S+ A + V +E +N++ P + T+V S E +P ++
Sbjct: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
Query: 286 TV--DDLDDGANGEI 298
V D D G G +
Sbjct: 198 NVLATDQDSGIYGTV 212
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 482 bits (1240), Expect = e-135
Identities = 414/1471 (28%), Positives = 646/1471 (43%), Gaps = 151/1471 (10%)
Query: 2706 PSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERP---ENNKGGIFVIEQET 2762
P F Y T+ E+ G+ V +LR + + ++ F ++ T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 2763 GTIKLDKRLDRETSPAFHFKVAAT---IPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSY 2819
G + + LDRET F+V A +P T I V D ND+ PVFE Y
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLT----ILVTDTNDHDPVFEQQEY 294
Query: 2820 DTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLK 2879
+ E + VG ++ VRA D D N + Y L S E F ID +G I T
Sbjct: 295 KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSP-SEVFEIDPRSGVIRTRG 353
Query: 2880 DLDHETDPTFTFSVVASDLG-EAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDP 2938
+D E ++ +V ASD G + S+TA V + V D NDNAP F+++ Y V+E
Sbjct: 354 PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVT 413
Query: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIY 2998
PG V ++ DRD N V Y I GN RG+F L V PLD E Y
Sbjct: 414 PGAPVLRVTASDRDKGS-NAVVHYSIMSGNARGQFYLDAQTGALDVV--SPLDYETTKEY 470
Query: 2999 FLNITATDG----LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAK 3054
L + A DG L +V V V D+NDN+P+ + A + E +P ++L V A
Sbjct: 471 TLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAI 530
Query: 3055 DADIGSNGYIRYSLYGSGNS-EFFLDPESGELKTLALLDRERIPVYSLMAKATDGG--GR 3111
DAD G N + Y L G G+ F ++ +G + A LDRE + YS +A D G
Sbjct: 531 DADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL 590
Query: 3112 FCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLA 3171
+++ + + DVNDN P F+ Y + E+ A + V AVD D + + Y +
Sbjct: 591 TASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQIT 648
Query: 3172 D-SAGGVFSIDSSSG--IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLD 3228
+ FSI S SG ++ L PLD + + Y ++V A+D + + + + V D
Sbjct: 649 SGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQ----IVVNVTD 704
Query: 3229 INDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINP 3288
N + PVF+ Y V V ED GT V+ + AT +D G NA ITY + Q F+I+
Sbjct: 705 ANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDA 762
Query: 3289 KTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSA 3348
TG ++ LDYE + L + A+D G P S + I + DVNDN P+F +D Y
Sbjct: 763 DTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
Query: 3349 VISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDR-DNEFTVDPVLGLVKVKKKLDRE 3407
+ ED SV+ + A D DS NG++ ++ GD D +F V+ G+V+ ++LDRE
Sbjct: 823 SVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE 882
Query: 3408 RVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQ 3467
V+ Y L AVD G+P + V + + DVNDN PVF + ++EN P+G ++ +
Sbjct: 883 NVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVAR 942
Query: 3468 LVVTDRDSFHNGPPFSFSILSGNEEEEFVLDP-HGILRSAVVFQHTESLEYVLCVQAKDS 3526
+ TD D N + I+ GN E F LD G L + V + + EYVL +QA +
Sbjct: 943 VTATDPDEGTNA-QIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSA 1001
Query: 3527 GKPQQVSHTYIRVRVIEESTHKPTAIPLEI----FIVTMEDDFPGGVIGKIHATDQDMYD 3582
VS + VR+++ + + P EI ++ FPGG IG++ A D D+ D
Sbjct: 1002 ---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISD 1058
Query: 3583 VLTFAL-KSEQKSLFKVNSHDGKIIALGGLDSGK---YVLNVSVSDGRFQVPIDVVVHVE 3638
LT++ + + SL +N+ G++ LD+ + +++V VSDG V + V
Sbjct: 1059 SLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVT 1118
Query: 3639 QLVHEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLRNAVLTQKQDSLRIISIQ---PVAG 3695
+ EML +++T+R E++SPE F+ + F + + A L D + + ++Q G
Sbjct: 1119 IITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVA-ATLATPPDHVVVFNVQRDTDAPG 1177
Query: 3696 TNQLDMLFAVEMHSSEFYKPAYLIQKLSNARRHLE-------NIMRISAILEKNCSGLDC 3748
+ L++ +V P +L + R +L + R+ + C C
Sbjct: 1178 GHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPC 1237
Query: 3749 QE-QHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTC----NGGLCPGSNDPCVEKP 3803
+ C L DS A S++ + F +RC C G C D C +P
Sbjct: 1238 ENYMRCVSVLRFDSSAPFIASSS-VLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRP 1296
Query: 3804 CPGDMQCVS-----------------YEASRRP---------------------FLCQCP 3825
C +C S E S R F C CP
Sbjct: 1297 CGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCP 1356
Query: 3826 PGKLGE--CSGHTSLSFAGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMY----TRA 3879
G + C T+ SF +S+I +R + F LAL T + +G+++Y
Sbjct: 1357 SGDFEKPYCQ-VTTRSFPAHSFITFR--GLRQRFHFTLALSFATKERDGLLLYNGRFNEK 1413
Query: 3880 NPCIILKIVDGKLWFQLDCGSGPGILGIS---GRAVNDGSWHSVFLELNRN--FTSLSLD 3934
+ + L+++ ++ QL +G +S V+DG WH+V L+ L
Sbjct: 1414 HDFVALEVIQEQV--QLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLP 1471
Query: 3935 DSYVERRRAPLYFQTLSTESSIYFGALV----------QADNIRSLTDTRVTQVLSG--- 3981
E++ A + T ++ FG+++ Q + +SL D +L G
Sbjct: 1472 QGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSL-DLTGPLLLGGVPD 1530
Query: 3982 -----------FQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLGCVLYPDACKRSPC 4030
F GC+ L + ++ A+ + GC + C + C
Sbjct: 1531 LPESFPVRMRQFVGCM-------RNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSNTC 1583
Query: 4031 QHGGSCTGLPSGGYQCTCLSQFTGRNCESEI 4061
+GG+C + C C F G++C E+
Sbjct: 1584 HNGGTCVN-QWDAFSCECPLGFGGKSCAQEM 1613
Score = 422 bits (1086), Expect = e-117
Identities = 319/1016 (31%), Positives = 497/1016 (48%), Gaps = 75/1016 (7%)
Query: 933 SPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR----FEIDKA 988
+P F P SY V E+ P GT +A L DPD G G++ Y++ ++ R F +D
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 989 SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV 1048
+GA+ ++ELD E + + V A+D G P S+++ + + V D N+ H P F
Sbjct: 238 TGAVTTAEELDRETKSTHVFRVTAQDHGMP-RRSALATLTILVTDTND--HDPVFEQQEY 294
Query: 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADI 1105
S++EN +G VL V A D D+ + I Y + +GSG F ID SGVI
Sbjct: 295 KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
Query: 1106 LDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPK 1163
+DRE + SY LTV A+D+G P +T V++ VED NDNAP SE Y V E+
Sbjct: 355 VDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTP 414
Query: 1164 DVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLE 1223
V+++ A D D SN + Y I SGN + F ++ +TG + S LD E E+ L
Sbjct: 415 GAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS-PLDYETTKEYTLR 473
Query: 1224 VTVTDGGPSPKQSTIWVV-VQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFD 1282
V DGG P + +V VQVLD NDN P F +Q + E G + A D
Sbjct: 474 VRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLE--SVPLGYLVLHVQAID 531
Query: 1283 RDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILT--IKAVDNGRPQKS 1340
D G NA + Y + D F I+ TG +S + D + ++A D+G P +
Sbjct: 532 ADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALT 591
Query: 1341 STARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV-TEIVGVVSV-QPANTPLWFDIV 1398
++A + + + +P TF +P Y + E V T +V V +V + A++ + + I
Sbjct: 592 ASASVSVTVLDVNDNNP---TFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQIT 648
Query: 1399 GGNFDSAFD--AEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDN 1456
GN + F ++ G G + +A PLD + Y ++V +DGT Q+ + V D N +
Sbjct: 649 SGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTH 708
Query: 1457 GPEFSQPNYDVTISEDVLPDTEILQIEATDRD--EKHKLSYTVHSSIDSISMRKFRIDPS 1514
P F +Y V ++ED T ++ I ATD D E +++Y + SI +FRID
Sbjct: 709 RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-----QFRIDAD 763
Query: 1515 TGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEAS 1574
TG + T LD+E Q + L I RD P + + + + V D ND++P F Y+ S
Sbjct: 764 TGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGS 823
Query: 1575 VFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGN-MFKIEPVLGIITICKEPDMTT 1633
V+E ++VLQ++A D+D G N + YT + G+ G+ F +E GI+ + D
Sbjct: 824 VYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDREN 883
Query: 1634 MGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILI 1693
+ Q+VL D+G PP V ++V +++ P F ++ V EN IG +V +
Sbjct: 884 VAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARV 943
Query: 1694 SAI-----SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG 1748
+A + + ++Y++ +G+I +F ++ +SG +T LDYE Y L+IQAT+ A
Sbjct: 944 TATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATS-AP 1002
Query: 1749 MASNATVNIQIVDENDNAPV-----FLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDA 1803
+ S ATV+++++D NDN PV LF+ Y + S + P +I R + A D
Sbjct: 1003 LVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGR--------VPAHDP 1054
Query: 1804 DSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTA 1863
D + + L Y +++STG ++ LD+ V V D G +TA
Sbjct: 1055 DISDS--LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTA 1111
Query: 1864 ESPVEVNIEVTD----------VNDNPP---------VFTQAVFETILLLPTYVGV 1900
+ + V I +TD + D P +F QAV T+ P +V V
Sbjct: 1112 QCALRVTI-ITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVV 1166
Score = 395 bits (1016), Expect = e-109
Identities = 305/1030 (29%), Positives = 493/1030 (47%), Gaps = 98/1030 (9%)
Query: 1453 NNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKH--KLSYTVHSSIDSISMRKFR 1510
N + P+F P+Y T+ E+ T + + A D DE +L YT+ + DS S + F
Sbjct: 174 NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFS 233
Query: 1511 IDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPL 1570
+DP TG + TAE LD E + H+ + +D P R LA + + V D NDH P F
Sbjct: 234 LDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQE 293
Query: 1571 YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGN---MFKIEPVLGIITICK 1627
Y+ S+ E+ +G VL V A D D NA ++Y + G+ G+ +F+I+P G+I
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
Query: 1628 EPDMTTMGQFVLSIKVTDQGSP--PMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVD 1685
D + + L+++ +DQG P S TA V +SV +++ P+F K Y +V E+V
Sbjct: 354 PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVT 413
Query: 1686 IGTSVILISAI-----SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLI 1740
G V+ ++A S + + Y + G+ G F ++ +G + LDYE T Y L
Sbjct: 414 PGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLR 473
Query: 1741 IQA--------TNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLD 1792
++A +N++G+ V +Q++D NDNAP+F+ + + ++ E+ P+ +V
Sbjct: 474 VRAQDGGRPPLSNVSGL-----VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLV---- 524
Query: 1793 NSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVH 1852
L ++A DAD+ NA L Y++ FT+++ TG I A LD E + + F V
Sbjct: 525 ---LHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVE 581
Query: 1853 VRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDS 1912
RD G+P LTA + V++ V DVNDN P FTQ + L VG V+ VSA D D+
Sbjct: 582 ARDHGTPALTASA--SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
Query: 1913 EVPPELTYSLMEGSL-DHFLIDSNSG----VLTIKNNNLSKDHYMLIVKVSDGKFYSTSM 1967
+TY + G+ + F I S SG L + + + Y+L V SDG T+
Sbjct: 640 H--SVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQ 697
Query: 1968 VTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL--NEPLKYSILNPGNK 2025
+ + V +A F S Y+ +++E+ T V +++A N + Y + + +
Sbjct: 698 IVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ 757
Query: 2026 FKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFV 2085
F+I + +G + TT D E+Q Y L + A + + + + D+NDN+P F+
Sbjct: 758 FRIDADTGAV-TTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFL 816
Query: 2086 GLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQ---DDYGHFEINPNSGNVILK 2142
Y +V D P T + Q++A D+D G NG V Y Q D G F + SG I++
Sbjct: 817 RDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSG--IVR 874
Query: 2143 EAFNSDLSNI-EYGVTILAKDGGKPSLSTSVELPITI--VNKAMPVFDKPFYTASVNEDI 2199
D N+ +Y + A D G P T +E+ +T+ VN PVF++ + V E+
Sbjct: 875 TLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENS 934
Query: 2200 RMNTPILSINATSPE---GQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKL 2256
+ + + AT P+ I+Y I++G+ + F +D +G L + LDYE Y L
Sbjct: 935 PIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVL 994
Query: 2257 TIRASDALTGARAEVTVDLLVNDVNDNPPIFD--QPTYN--TTLSEASLIGTPVLQVVSI 2312
I+A+ A +RA V V LL D NDNPP+ + +N T +S G + +V +
Sbjct: 995 VIQATSAPLVSRATVHVRLL--DRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAH 1052
Query: 2313 DADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLD-----------------HE 2355
D D ++ + + N +++S+G + +R LD H
Sbjct: 1053 DPDISDSLTYSF----ERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHS 1108
Query: 2356 LVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTC 2415
+ C L+V I + E+L H + D P E ++S L G F+
Sbjct: 1109 VTAQCALRVTII-------TDEMLTHSITLRLEDMSP-------ERFLSPLL--GLFIQA 1152
Query: 2416 VQASDADSSD 2425
V A+ A D
Sbjct: 1153 VAATLATPPD 1162
Score = 375 bits (964), Expect = e-103
Identities = 319/1089 (29%), Positives = 498/1089 (45%), Gaps = 106/1089 (9%)
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASL----NLLPFVINQFT 525
P+FQ P Y A V E+ P GT V ++ A D D+GE G + Y++ +L + F ++ T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 526 GVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQG 585
G ++T EELD E+ + F V A D G P R + +TI + + ND+ P+FE+ +
Sbjct: 239 GAVTTAEELDRETK-STHVFRVTAQDHGMP-RRSALATLTILVTDTNDHDPVFEQQEYKE 296
Query: 586 VISYDFPVGGHITAVSAIDIDELEL--VKYKIISGN---ELGFFYLNPDSGVLQLKKSLT 640
+ + VG + V A D D + Y+++ G+ F ++P SGV++ + +
Sbjct: 297 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVD 356
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+++ + L + A+D P S +V
Sbjct: 357 REEVES--YQLTVEASDQGRDPGPRSTTAAVF---------------------------- 386
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L++ED N P F + V V+ED+ GA +L++ A D D G N
Sbjct: 387 -----LSVEDD-------NDNAPQFSEK-RYVVQVREDVTPGAPVLRVTASDRDKGSNAV 433
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWR-LLTI 819
V ++I GN F +D +TG L V+ P+D E T Y L + D G P S+ L+T+
Sbjct: 434 VHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTV 493
Query: 820 NVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSV--LTDTQQF 877
V D NDN+P+F+ + +LES +G ++ V+A D D G N + Y + + F
Sbjct: 494 QVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPF 553
Query: 878 AINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI 937
IN+ TG + VA +LDRE YS +EARD + V++ V DVND +P F
Sbjct: 554 TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVL--DVNDNNPTFT 611
Query: 938 PSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGA--IRL 994
Y+V++ ED VGT + + D D + Y + + + RF I SG + L
Sbjct: 612 QPEYTVRLNEDAAVGTSVVTVSAVDRDAH--SVITYQITSGNTRNRFSITSQSGGGLVSL 669
Query: 995 SKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE 1054
+ LDY+ ++ Y L V A D R + + V V D N H P F +V E
Sbjct: 670 ALPLDYKLERQYVLAVTASDGTR----QDTAQIVVNVTDANT--HRPVFQSSHYTVNVNE 723
Query: 1055 NSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSY 1114
+ GT+V+ ++A DED+G + I Y + D + +F ID ++G +T LD E SY
Sbjct: 724 DRPAGTTVVLISATDEDTGENARITYFMEDS--IPQFRIDADTGAVTTQAELDYEDQVSY 781
Query: 1115 WLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAED 1174
L + A D G+ T + I V DVNDNAP Y V E+ P SV+QI A D
Sbjct: 782 TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD 841
Query: 1175 PDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPK 1234
DS N ++ Y G+ + I T I T R+LDRE A++ L D G P
Sbjct: 842 RDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPA 901
Query: 1235 QSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYS 1294
++ + V V VLD NDN P F + + + + E G + R A D DEG NA+I Y
Sbjct: 902 RTPMEVTVTVLDVNDNPPVFEQDEFDVFVEE--NSPIGLAVARVTATDPDEGTNAQIMYQ 959
Query: 1295 IVDGNDDGKFFIDPKTGMVSS--RKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKK 1352
IV+GN F +D +G +++ + +L I+A S A +H+ + +
Sbjct: 960 IVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATS---APLVSRATVHVRLLDR 1016
Query: 1353 PPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTP-----LWFDIVGGNFDSAFD 1407
P+ F+ F N+ S G + PA+ P L + GN S
Sbjct: 1017 NDNPPVLGNFEILFNNYVTNRSSSFPG--GAIGRVPAHDPDISDSLTYSFERGNELSLVL 1074
Query: 1408 AEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDV 1467
G + +++ LD + MSV V+DG + Q ++V
Sbjct: 1075 LNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRV----------------T 1118
Query: 1468 TISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHE 1527
I++++L + L++E D + LS + I +++ P V++ +R D +
Sbjct: 1119 IITDEMLTHSITLRLE--DMSPERFLSPLLGLFIQAVA-ATLATPPDHVVVFNVQR-DTD 1174
Query: 1528 AQDKHILNI 1536
A HILN+
Sbjct: 1175 APGGHILNV 1183
Score = 351 bits (901), Expect = 8e-96
Identities = 286/954 (29%), Positives = 468/954 (49%), Gaps = 51/954 (5%)
Query: 735 VKEDLPVGANILKIKAYDADSGFNGKVLFTIS---DGNTDSCFNIDMETGQLKVLMPMDR 791
V E+ P G + ++A D D G G++ +T+ D ++ F++D TG + +DR
Sbjct: 190 VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDR 249
Query: 792 EHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEII 851
E ++ +T D G P++S+ LTI V D ND+ PVF Q Y ++ E+ +G E++
Sbjct: 250 ETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVL 309
Query: 852 QVEARDKDLGSNGEVTYSVL-----TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEA 906
V A D D N + Y +L + ++ F I+ +G++ +DRE +Y L +EA
Sbjct: 310 TVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEA 369
Query: 907 RDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLG 966
D+ + + + ++D ND +P F Y V+V ED+ G + + D D G
Sbjct: 370 SDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKG 429
Query: 967 LGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVS 1025
V YS+++ + G+F +D +GA+ + LDYE + Y L VRA+D GRP LS+VS
Sbjct: 430 SNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRP-PLSNVS 488
Query: 1026 -FVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD 1084
V V+V+D+N+N P F +V E+ +G VL V A D D+G + ++Y +
Sbjct: 489 GLVTVQVLDINDN--APIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRL-- 544
Query: 1085 GSGLGR---FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDV 1141
+G+G F+I++ +G I+ A LDRE + Y V A D G L ++ V + V DV
Sbjct: 545 -AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDV 603
Query: 1142 NDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIK 1201
NDN P ++P Y + E++ SV+ + A D D+ S +TY+ITSGN +N F+I +
Sbjct: 604 NDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS--VITYQITSGNTRNRFSITSQ 661
Query: 1202 T-GLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ 1260
+ G + + + LD + + ++ L VT +DG +Q T +VV V D N ++P F Y
Sbjct: 662 SGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYT 718
Query: 1261 IKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF- 1319
+ + E + G + A D D G NA I+Y + D +F ID TG V+++ +
Sbjct: 719 VNVNE--DRPAGTTVVLISATDEDTGENARITYFMEDSIP--QFRIDADTGAVTTQAELD 774
Query: 1320 --TAGSYDILTIKAVDNGRPQKSSTARLHI--EWIKKPPPSPIPLTFDEPFYNFTVMESD 1375
SY L I A DNG PQKS T L I + P + ++ Y V
Sbjct: 775 YEDQVSY-TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYE-DVPPFT 832
Query: 1376 RVTEIVGVVSVQPANTPLWFDIVGG-NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVE 1434
V +I N +++ GG + D F E G + + LD E + Y +
Sbjct: 833 SVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAY 892
Query: 1435 VTD-GTNVAVT--QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKH 1491
D G A T +V + VLD NDN P F Q +DV + E+ + ++ ATD DE
Sbjct: 893 AVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGT 952
Query: 1492 KLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
+ ++ ++ F++D +G L LD+E + +++L I R A
Sbjct: 953 N-AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSR---AT 1008
Query: 1552 VIVNVEDANDHSPYFTN--PLYEASVF--ESAALGSAVLQVTALDKDKGENAELIYTIEA 1607
V V + D ND+ P N L+ V S+ G A+ +V A D D ++ L Y+ E
Sbjct: 1009 VHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDS--LTYSFER 1066
Query: 1608 GNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661
GN ++ + G + + + D + ++S+ V+D G ++A +R+++
Sbjct: 1067 GNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTI 1119
Score = 346 bits (887), Expect = 3e-94
Identities = 276/939 (29%), Positives = 436/939 (46%), Gaps = 53/939 (5%)
Query: 826 DNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSV--LTDT---QQFAIN 880
+ +P F SY + E+ GT + + A D D G G + Y++ L D+ Q F+++
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
TG V A++LDRE+K+ + ++ A+D + ++ TL + + D ND P F
Sbjct: 236 PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRS--ALATLTILVTDTNDHDPVFEQQE 293
Query: 941 YSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR----FEIDKASGAIRLSK 996
Y + E+L VG + + D D + Y L+ G FEID SG IR
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
Query: 997 ELDYEKQQFYNLTVRAKDKGR-PVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKEN 1055
+D E+ + Y LTV A D+GR P S+ + V + V D N+N P F + V V+E+
Sbjct: 354 PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDN--APQFSEKRYVVQVRED 411
Query: 1056 SRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYW 1115
G VL+VTA D D G + + YSI G+ G+F +D ++G + LD ET Y
Sbjct: 412 VTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYT 471
Query: 1116 LTVYATDRGVVPLYSTIE-VYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAED 1174
L V A D G PL + V ++V D+NDNAP+ + V+E+ P V+ +QA D
Sbjct: 472 LRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAID 531
Query: 1175 PDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPK 1234
D+ N +L YR+ F IN TG I+ + +LDRE+ + V D G
Sbjct: 532 ADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAA-ELDREEVDFYSFGVEARDHGTPAL 590
Query: 1235 QSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYS 1294
++ V V VLD NDN P F + Y ++L E G + A DRD ++ I+Y
Sbjct: 591 TASASVSVTVLDVNDNNPTFTQPEYTVRLNE--DAAVGTSVVTVSAVDRD--AHSVITYQ 646
Query: 1295 IVDGNDDGKFFIDPKTG----MVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWI 1350
I GN +F I ++G ++ + +L + A D R TA++ +
Sbjct: 647 ITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR---QDTAQIVVNVT 703
Query: 1351 KKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDS--AFDA 1408
P+ F Y V E V ++S +T I DS F
Sbjct: 704 DANTHRPV---FQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRI 760
Query: 1409 EKGVGTIVIAKPLDAEQRSIYNMSVEVTDG---TNVAVTQVFIKVLDNNDNGPEFSQPNY 1465
+ G + LD E + Y +++ D T + I V D NDN P+F + +Y
Sbjct: 761 DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY 820
Query: 1466 DVTISEDVLPDTEILQIEATDRDE--KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAER 1523
++ EDV P T +LQI ATDRD ++ YT D F ++ ++G++ T R
Sbjct: 821 QGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDG--DFIVESTSGIVRTLRR 878
Query: 1524 LDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGS 1583
LD E +++L D+ P R V V V D ND+ P F ++ V E++ +G
Sbjct: 879 LDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGL 938
Query: 1584 AVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKV 1643
AV +VTA D D+G NA+++Y I GN +F+++ G +T + D ++VL I+
Sbjct: 939 AVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA 998
Query: 1644 TDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQ----- 1698
T S P+ + A V + + +++ P + +++ N V +S AI +
Sbjct: 999 T---SAPLVSRATVHVRLLDRNDNPP--VLGNFEILFNNYVTNRSSSFPGGAIGRVPAHD 1053
Query: 1699 ----STLIYEVKDGDINGIFTINPYSGVITTQKALDYER 1733
+L Y + G+ + +N +G + +ALD R
Sbjct: 1054 PDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNR 1092
Score = 338 bits (868), Expect = 6e-92
Identities = 266/872 (30%), Positives = 419/872 (48%), Gaps = 64/872 (7%)
Query: 1143 DNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITS---GNPQNFFAIN 1199
+ AP P Y V EN P V ++A DPD +L Y + + FF+++
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 1200 IKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVY 1259
TG + TT+ +LDRE ++ H VT D G + + + + V D ND+ P F ++ Y
Sbjct: 236 PVTGAV-TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
Query: 1260 QIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGK---FFIDPKTGMVSSR 1316
+ L R+ + G + A D D PNA I Y +++G+ F IDP++G++ +R
Sbjct: 295 KESL--RENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTR 352
Query: 1317 ---KQFTAGSYDILTIKAVDNGRP--QKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTV 1371
+ SY LT++A D GR +S+TA + + +P F E Y V
Sbjct: 353 GPVDREEVESYQ-LTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAP---QFSEKRYVVQV 408
Query: 1372 MESDRVTEIVGVVSV------QPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQ 1425
E VT V+ V + +N + + I+ GN F + G + + PLD E
Sbjct: 409 RED--VTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET 466
Query: 1426 RSIYNMSVEVTDGTNVAVTQ----VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQ 1481
Y + V DG ++ V ++VLD NDN P F + T+ E V +L
Sbjct: 467 TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLH 526
Query: 1482 IEATDRD--EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVR 1539
++A D D + +L Y + F I+ TG + A LD E D + + R
Sbjct: 527 VQAIDADAGDNARLEYRLAGVGHDF---PFTINNGTGWISVAAELDREEVDFYSFGVEAR 583
Query: 1540 DQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENA 1599
D P A V V V D ND++P FT P Y + E AA+G++V+ V+A+D+D ++
Sbjct: 584 DHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHS 641
Query: 1600 ELIYTIEAGNTGNMFKI--EPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIV 1657
+ Y I +GNT N F I + G++++ D Q+VL++ +D TA +
Sbjct: 642 VITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD---GTRQDTAQI 698
Query: 1658 RISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST-----LIYEVKDGDING 1712
++VT ++ P F Y VNE+ GT+V+LISA + T + Y ++D
Sbjct: 699 VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ- 757
Query: 1713 IFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIV--DENDNAPVFL 1770
F I+ +G +TTQ LDYE SY L I A + + T ++I+ D NDNAP FL
Sbjct: 758 -FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFL 816
Query: 1771 FSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV-ESTAKKFFTVDSS 1829
Y GS+ E P + S L I ATD DS N + Y F V+S+
Sbjct: 817 RDSYQGSVYEDVPPFT-------SVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
Query: 1830 TGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFE 1889
+G +RT+ LD E +A + + D G P A +P+EV + V DVNDNPPVF Q F+
Sbjct: 870 SGIVRTLRRLDRENVAQYVLRAYAVDKGMP--PARTPMEVTVTVLDVNDNPPVFEQDEFD 927
Query: 1890 TILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL-DHFLIDSNSGVLT--IKNNNL 1946
+ + +G+ V +V+ATDPD ++ Y ++EG++ + F +D SG LT + +
Sbjct: 928 VFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYE 987
Query: 1947 SKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
+ Y+L+++ + S + V + + + D+
Sbjct: 988 DRPEYVLVIQATSAPLVSRATVHVRLLDRNDN 1019
Score = 332 bits (850), Expect = 7e-90
Identities = 274/973 (28%), Positives = 464/973 (47%), Gaps = 68/973 (6%)
Query: 1252 PQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYS---IVDGNDDGKFFIDP 1308
PQF YQ +PE + G P+ A D DEG + Y+ + D + F +DP
Sbjct: 179 PQFQPPSYQATVPEN--QPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDP 236
Query: 1309 KTGMVSSRKQFT--AGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPF 1366
TG V++ ++ S + + A D+G P++S+ A L I P+ F++
Sbjct: 237 VTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV---FEQQE 293
Query: 1367 YNFTVMESDRVTEIVGVVSVQPANTPLWFDIV-------GGNFDSAFDAEKGVGTIVIAK 1419
Y ++ E+ V V V + P +I+ GG+ F+ + G I
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
Query: 1420 PLDAEQRSIYNMSVEVTD-----GTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
P+D E+ Y ++VE +D G VF+ V D+NDN P+FS+ Y V + EDV
Sbjct: 354 PVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVT 413
Query: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMR-KFRIDPSTGVLYTAERLDHEAQDKHI 1533
P +L++ A+DRD+ VH SI S + R +F +D TG L LD+E ++
Sbjct: 414 PGAPVLRVTASDRDKGSNA--VVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYT 471
Query: 1534 LNIMVRDQEFPYRRNLARVI-VNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALD 1592
L + +D P N++ ++ V V D ND++P F + ++A+V ES LG VL V A+D
Sbjct: 472 LRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAID 531
Query: 1593 KDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMS 1652
D G+NA L Y + F I G I++ E D + + ++ D G+P ++
Sbjct: 532 ADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALT 591
Query: 1653 ATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI---SQSTLIYEVKDGD 1709
A+A V ++V ++++P F +Y +NE+ +GTSV+ +SA+ + S + Y++ G+
Sbjct: 592 ASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGN 651
Query: 1710 INGIFTINPYS--GVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAP 1767
F+I S G+++ LDY+ Y L + A++ A + + + D N + P
Sbjct: 652 TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD-GTRQDTAQIVVNVTDANTHRP 710
Query: 1768 VFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVD 1827
VF S Y+ +++E P + V ++I ATD D+ NA + Y + +S + F +D
Sbjct: 711 VFQSSHYTVNVNEDRPAGTTV-------VLISATDEDTGENARITYFMEDSIPQ--FRID 761
Query: 1828 SSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAV 1887
+ TGA+ T A LD+E + + RD+G PQ + + +E I V DVNDN P F +
Sbjct: 762 ADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLE--ILVNDVNDNAPQFLRDS 819
Query: 1888 FETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEG--SLDHFLIDSNSGVL----TI 1941
++ + VL++SATD DS + + Y+ G F+++S SG++ +
Sbjct: 820 YQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL 879
Query: 1942 KNNNLSKDHYMLIVKVSDGKF---YSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNI 1998
N+++ Y+L D + VT+ V + D+ F Q + + EN+
Sbjct: 880 DRENVAQ--YVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIG 937
Query: 1999 TKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELYELVV 2054
VA V A N + Y I+ N F++ SG + T V D E++ Y LV+
Sbjct: 938 LAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL-TALVDLDYEDRPEYVLVI 996
Query: 2055 EASRELDHLRVARVVVRVNIEDINDNSPVF----VGLPYYAAVQVDAEPGTLIYQVTAID 2110
+A+ V+R V V + D NDN PV + Y + + PG I +V A D
Sbjct: 997 QAT---SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHD 1053
Query: 2111 KDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLST 2170
D + ++ ++ +N ++G + L A +++ +E +++L D G S++
Sbjct: 1054 PDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNN-RPLEAIMSVLVSD-GVHSVTA 1111
Query: 2171 SVELPITIVNKAM 2183
L +TI+ M
Sbjct: 1112 QCALRVTIITDEM 1124
Score = 330 bits (846), Expect = 2e-89
Identities = 290/983 (29%), Positives = 453/983 (46%), Gaps = 68/983 (6%)
Query: 1973 KEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAV------GNRLNEPLKYSILNPGNKF 2026
K +++ F Y ++ EN T VA + A+ RL + + N+F
Sbjct: 172 KRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQF 231
Query: 2027 -KIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFV 2085
+ +G + TT DRE + + V A R A + + + D ND+ PVF
Sbjct: 232 FSLDPVTGAV-TTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFE 290
Query: 2086 GLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGH-----FEINPNSGNVI 2140
Y +++ + E G + V A D D PN + Y L + G FEI+P SG +
Sbjct: 291 QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSG--V 348
Query: 2141 LKEAFNSDLSNIE-YGVTILAKDGGKP----SLSTSVELPITIVNKAMPVFDKPFYTASV 2195
++ D +E Y +T+ A D G+ S + +V L + N P F + Y V
Sbjct: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
Query: 2196 NEDIRMNTPILSINATSPE-GQGII--YIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTS 2252
ED+ P+L + A+ + G + Y I+ G+ QF +D TG L VVSPLDYE T
Sbjct: 409 REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTK 468
Query: 2253 AYKLTIRASDA----LTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQ 2308
Y L +RA D L+ VTV +L D+NDN PIF + T+ E+ +G VL
Sbjct: 469 EYTLRVRAQDGGRPPLSNVSGLVTVQVL--DINDNAPIFVSTPFQATVLESVPLGYLVLH 526
Query: 2309 VVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSID 2368
V +IDAD+ +N + Y++ ++ F I++ +G I A LD E V + V + D
Sbjct: 527 VQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEARD 584
Query: 2369 SGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDR 2428
G P+L++ V + + DVNDN P F Q Y ++E A G V V A D D+
Sbjct: 585 HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSV-- 642
Query: 2429 LEYSILSGNDRTSFLMDSKS--GVITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRV 2486
+ Y I SGN R F + S+S G+++L+ ++E Y L V+ SDG TAQ+ + V
Sbjct: 643 ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNV 702
Query: 2487 LGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLI 2546
AN + P F S Y V E+ AGT V+ + ATD D G +I+Y + + + R
Sbjct: 703 TDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDA 762
Query: 2547 DSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYR 2606
D+ G V T LD E+ + ++I R ++ + ++V D NDNAPQF+ Y+
Sbjct: 763 DT-GAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQ 821
Query: 2607 ASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNF 2666
SV DV V Q+ A D D G N R+ Y+ + D + ++ +G + T
Sbjct: 822 GSVYEDVPPFTSVLQISATDRDSGLNGRVFYT-FQGGDDGDGDFI-VESTSGIVRTLRRL 879
Query: 2667 NQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
++ AVD G+P + + V + VL P F Q ++ + E++ IG
Sbjct: 880 DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLA 939
Query: 2727 VDTLRIL-----PSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
V + + + + V G PE +F ++ +G + LD E P +
Sbjct: 940 VARVTATDPDEGTNAQIMYQIVEGNIPE-----VFQLDIFSGELTALVDLDYEDRPEYVL 994
Query: 2782 KVAATIPLDKVDIVFTVDVDIKVLDLNDNKPV---FET--SSYDTIIMEGMPVGTKLTQV 2836
+ AT +V V +++LD NDN PV FE ++Y T P G + +V
Sbjct: 995 VIQAT----SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRV 1049
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
A D D + +TYS ++ V+ ++++TG + + LD+ SV+ S
Sbjct: 1050 PAHDPD--ISDSLTYSFERGNELSLVL----LNASTGELKLSRALDNNRPLEAIMSVLVS 1103
Query: 2897 DLGEAFSLSSTALVSVRVTDIND 2919
D S TA ++RVT I D
Sbjct: 1104 DGVH----SVTAQCALRVTIITD 1122
Score = 317 bits (812), Expect = 2e-85
Identities = 283/998 (28%), Positives = 434/998 (43%), Gaps = 103/998 (10%)
Query: 156 PLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD-----LFSVHPTS 210
P F P +Y T+ E+ P T VA + A D D G G Y D FS+ P +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 211 GVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT 270
G ++ + L+ + K+ + + A D GM S+ A L + + N+H P
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHGMPRR-----SALATLTILVTDTNDHDPVFEQQE 293
Query: 271 HVPFSLEK-EPTYAVVTV----DDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYK 325
+ E E Y V+TV D AN + G P + F + +
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG 353
Query: 326 IKERKQIDWESFPYGYNLTLQAKDKG-SPQKCSALKAVYIG-NPTRDTVPIRFEKEVYDV 383
+R++++ Y LT++A D+G P S AV++ D P +F ++ Y V
Sbjct: 354 PVDREEVE------SYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAP-QFSEKRYVV 406
Query: 384 SISEFSPPGVVVAIVKLSPEP----IDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVK 439
+ E PG V V S V Y + G F ++ ++G + PL+
Sbjct: 407 QVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET 466
Query: 440 KEVYKLEVTNKEG------DLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLT 493
+ Y L V ++G ++ VT+ + D ND+ P F + A V ESVP+G VL
Sbjct: 467 TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLH 526
Query: 494 VSASDKDKGENGYITYSIASL-NLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDW 552
V A D D G+N + Y +A + + PF IN TG IS ELD E + Y F V A D
Sbjct: 527 VQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDRE-EVDFYSFGVEARDH 585
Query: 553 GSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVK 612
G+P S +V++ + +VNDN+P F + ++ D VG + VSA+D D ++
Sbjct: 586 GTPALTAS-ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVIT 644
Query: 613 YKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVL 672
Y+I SGN F + SG + +L + L +TA+DG D I ++V
Sbjct: 645 YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR-QDTAQIVVNVT 703
Query: 673 HGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSD 732
N P F S +
Sbjct: 704 --------------------------------------------DANTHRPVFQSSHYT- 718
Query: 733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDRE 792
V V ED P G ++ I A D D+G N ++ + + D F ID +TG + +D E
Sbjct: 719 VNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYE 776
Query: 793 HTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQ 852
Y L IT D G PQKS L I V D NDN+P F++DSY ++ E T ++Q
Sbjct: 777 DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQ 836
Query: 853 VEARDKDLGSNGEVTYSVLTDTQ---QFAINSSTGIVYVADQLDRESKANYSLKIEARDK 909
+ A D+D G NG V Y+ F + S++GIV +LDRE+ A Y L+ A DK
Sbjct: 837 ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDK 896
Query: 910 AESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGG 969
+ VT+ V DVND P F + V V E+ P+G +A + DPD G
Sbjct: 897 GMPPARTPMEVTVTVL--DVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNA 954
Query: 970 QVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVE 1028
Q+ Y +V + F++D SG + +LDYE + Y L ++A L S + V
Sbjct: 955 QIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATS----APLVSRATVH 1010
Query: 1029 VEVVDVNENLHTPYFPDFAVV----GSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD 1084
V ++D N+N P +F ++ + + +S G ++ +V A D D + YS
Sbjct: 1011 VRLLDRNDN--PPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDI--SDSLTYSFER 1066
Query: 1085 GSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATD 1122
G+ L ++ +G + + LD ++V +D
Sbjct: 1067 GNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSD 1104
Score = 302 bits (774), Expect = 4e-81
Identities = 240/746 (32%), Positives = 352/746 (47%), Gaps = 37/746 (4%)
Query: 2919 DNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLV 2978
+ AP F Y+ V E+ P G VA L D D + R + R L
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 2979 QSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---AMVEVSVSDVNDNSPVCDQVAYT 3035
V LDRE + + +TA D + A + + V+D ND+ PV +Q Y
Sbjct: 236 PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
Query: 3036 ALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLY-GSGNSE---FFLDPESGELKTLALL 3091
L E++ +L V A D D N I Y L GSG S F +DP SG ++T +
Sbjct: 296 ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
Query: 3092 DRERIPVYSLMAKATDGGG----RFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATK 3147
DRE + Y L +A+D G R + + L +ED NDN P FS Y V E+
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 3148 ALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVR 3206
A + RV A D D G N V YS+ + +A G F +D+ +G + + PLD E Y + VR
Sbjct: 416 APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVR 475
Query: 3207 ATD--QSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKD 3264
A D + P ++S L VT+ VLDINDN P+F + TV E G VL V A D
Sbjct: 476 AQDGGRPPLSNVSGL--VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDAD 533
Query: 3265 IGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAV 3324
G NA + Y + F IN TG ISV+ LD E + VEA+D GTPAL+A
Sbjct: 534 AGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTAS 593
Query: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGD 3384
A+V++ + DVNDN P F+Q Y+ ++EDA VG SV+ + A VD + I + I +G+
Sbjct: 594 ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSA--VDRDAHSVITYQITSGN 651
Query: 3385 RDNEFTVDPVL--GLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDN 3442
N F++ GLV + LD + Y L V A D TA + ++++D N +
Sbjct: 652 TRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTH 708
Query: 3443 SPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH-G 3501
PVF ++YT + E++P GT+++ + TD D+ N + + +F +D G
Sbjct: 709 RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENA---RITYFMEDSIPQFRIDADTG 765
Query: 3502 ILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTM 3561
+ + + + + Y L + A+D+G PQ+ TY+ + V + + + P +
Sbjct: 766 AVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825
Query: 3562 EDDFPGGVIGKIHATDQDM----YDVLTFALKSEQKSLFKVNSHDGKIIALGGLDS---G 3614
ED P + +I ATD+D TF + F V S G + L LD
Sbjct: 826 EDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVA 885
Query: 3615 KYVLNVSVSDGRF---QVPIDVVVHV 3637
+YVL D + P++V V V
Sbjct: 886 QYVLRAYAVDKGMPPARTPMEVTVTV 911
Score = 238 bits (608), Expect = 8e-62
Identities = 236/914 (25%), Positives = 397/914 (43%), Gaps = 102/914 (11%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE-AWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
L+RE + ++ V G A + I V D ND P+F Y ++ E+ +
Sbjct: 247 LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGY 306
Query: 176 SVAQVTATDADIGSNGEFYYYFK-----NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLE 230
V V ATD D N Y + ++F + P SGVI G ++ +E Y L
Sbjct: 307 EVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLT 366
Query: 231 ILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTI---HVVTHVPFSLEKEPTYAVVTV 287
+ A D+G S+TA +++ +E N++AP V V + VT
Sbjct: 367 VEASDQGRD---PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTA 423
Query: 288 DDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQA 347
D D G+N + SI++G+ QF+L + L+ +D+E+ Y L ++A
Sbjct: 424 SDRDKGSNAVVH-YSIMSGNARGQFYLDAQTGALDVVS-----PLDYETTKE-YTLRVRA 476
Query: 348 KDKGSP--QKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKL----S 401
+D G P S L V + + D PI F + ++ E P G +V V+ +
Sbjct: 477 QDGGRPPLSNVSGLVTVQVLD-INDNAPI-FVSTPFQATVLESVPLGYLVLHVQAIDADA 534
Query: 402 PEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDL-----KA 456
+ +EY+L+ F IN +G I A L+ + + Y V ++ A
Sbjct: 535 GDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
Query: 457 QVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIAS--- 513
V++++ D ND+ P F QP Y +NE VGTSV+TVSA D+D + ITY I S
Sbjct: 595 SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNT 652
Query: 514 LNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVND 573
N G++S LD++ + Y V ASD + + + + + N
Sbjct: 653 RNRFSITSQSGGGLVSLALPLDYKLERQ-YVLAVTASDG----TRQDTAQIVVNVTDANT 707
Query: 574 NSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVL 633
+ P+F+ ++ D P G + +SA D D E + + + F ++ D+G +
Sbjct: 708 HRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAV 767
Query: 634 QLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLA 693
+ L + D +S +++ + R+ + QK +
Sbjct: 768 TTQAEL--------------------DYEDQVSYTLAI----------TARDNGIPQK-S 796
Query: 694 EKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDA 753
+ ++ N ++ D F + QG +V ED+P ++L+I A D
Sbjct: 797 DTTYLEILVN---DVNDNAPQFLRDSYQG-----------SVYEDVPPFTSVLQISATDR 842
Query: 754 DSGFNGKVLFTISDGNT-DSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812
DSG NG+V +T G+ D F ++ +G ++ L +DRE+ Y+L D G P
Sbjct: 843 DSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPAR 902
Query: 813 SWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLT 872
+ +T+ V D NDN PVF QD + V + E+S IG + +V A D D G+N ++ Y ++
Sbjct: 903 TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVE 962
Query: 873 DT--QQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVN 930
+ F ++ +G + LD E + Y L I+A + L S T+ V L D N
Sbjct: 963 GNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA-----TSAPLVSRATVHVRLLDRN 1017
Query: 931 DCSPA-----FIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEI 985
D P + ++Y P G I + HDPD+ + N+ + +
Sbjct: 1018 DNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISDSLTYSFERGNELS-LVLL 1075
Query: 986 DKASGAIRLSKELD 999
+ ++G ++LS+ LD
Sbjct: 1076 NASTGELKLSRALD 1089
Score = 173 bits (438), Expect = 4e-42
Identities = 157/550 (28%), Positives = 253/550 (46%), Gaps = 44/550 (8%)
Query: 114 SAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTP 172
+A L+RE D Y V+ G L A V++ VLD+ND P F+ Y+V + E
Sbjct: 565 AAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAA 624
Query: 173 LRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSG--VISLSGRLNYDEKNRYDLE 230
+ TSV V+A D D S + N + FS+ SG ++SL+ L+Y + +Y L
Sbjct: 625 VGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLA 684
Query: 231 ILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDL 290
+ A D + TA++ V++ N H P + E P V +
Sbjct: 685 VTASDGTRQ--------DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISA 736
Query: 291 DDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDK 350
D GE ++ D + QF + + + + ++D+E Y L + A+D
Sbjct: 737 TDEDTGENARITYFMEDSIPQFRIDADTG-----AVTTQAELDYED-QVSYTLAITARDN 790
Query: 351 GSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID---- 406
G PQK + N D P +F ++ Y S+ E PP +++++S D
Sbjct: 791 GIPQKSDTTYLEILVNDVNDNAP-QFLRDSYQGSVYEDVPP--FTSVLQISATDRDSGLN 847
Query: 407 --VEYKLSPGEDAVY-FKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKA-----QV 458
V Y G+D F + SG++ T R L+ Y L + + +V
Sbjct: 848 GRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEV 907
Query: 459 TISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP 518
T+++ D ND+ P F+Q +D +V E+ P+G +V V+A+D D+G N I Y I N+
Sbjct: 908 TVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPE 967
Query: 519 -FVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPL 577
F ++ F+G ++ +LD+E PE Y +++A+ +P S V +R+ + NDN P+
Sbjct: 968 VFQLDIFSGELTALVDLDYEDRPE-YVLVIQAT--SAPL--VSRATVHVRLLDRNDNPPV 1022
Query: 578 ---FEKVACQGVI--SYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGV 632
FE + V S FP GG I V A D D + + Y GNEL LN +G
Sbjct: 1023 LGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGE 1081
Query: 633 LQLKKSLTNS 642
L+L ++L N+
Sbjct: 1082 LKLSRALDNN 1091
Score = 122 bits (306), Expect = 8e-27
Identities = 129/513 (25%), Positives = 222/513 (43%), Gaps = 53/513 (10%)
Query: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADF 102
FT Y + E++A T V + S + D I Y+I SG+ F
Sbjct: 610 FTQPEYTVRLNEDAAVGTSVVTVSAVDR---DAHSVITYQITSGNTRNRFS--------- 657
Query: 103 CFLRIRTKGGNSAI-----LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPL 157
I ++ G + L+ +++ Y+L V S A VN V D N RP+
Sbjct: 658 ----ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPV 711
Query: 158 FSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSG 217
F + Y+V + E P T+V ++ATD D G N Y+ ++ + F + +G ++
Sbjct: 712 FQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQA 771
Query: 218 RLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLE 277
L+Y+++ Y L I A D G+ S T L + + +N++AP ++ E
Sbjct: 772 ELDYEDQVSYTLAITARDNGIP-----QKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYE 826
Query: 278 KEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDW 334
P + V + D D G NG + + GD D F+ + + ++ +++D
Sbjct: 827 DVPPFTSVLQISATDRDSGLNGRV-FYTFQGGDDGDGDFIVESTSGI----VRTLRRLDR 881
Query: 335 ESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVV 394
E+ Y L A DKG P + ++ D P+ FE++ +DV + E SP G+
Sbjct: 882 ENVAQ-YVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPV-FEQDEFDVFVEENSPIGLA 939
Query: 395 VA-IVKLSPEP---IDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNK 450
VA + P+ + Y++ G F+++ SG + L+ + Y L +
Sbjct: 940 VARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT 999
Query: 451 EGDLKAQVTISIE--DANDHTPEFQ--QPLYDAYV---NESVPVGTSVLTVSASDKDKGE 503
L ++ T+ + D ND+ P + L++ YV + S P G ++ V A D D +
Sbjct: 1000 SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPDISD 1058
Query: 504 NGYITYSIASLNLLPFV-INQFTGVISTTEELD 535
+ +TYS N L V +N TG + + LD
Sbjct: 1059 S--LTYSFERGNELSLVLLNASTGELKLSRALD 1089
Score = 80.9 bits (198), Expect = 3e-14
Identities = 87/337 (25%), Positives = 139/337 (41%), Gaps = 55/337 (16%)
Query: 3792 CPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLS---FAGNSYIKY 3848
CP + C C CV+ + F C+CP G G+ + F G+S + +
Sbjct: 1571 CPAKKNVCDSNTCHNGGTCVNQWDA---FSCECPLGFGGKSCAQEMANPQHFLGSSLVAW 1627
Query: 3849 RLSENSKEEDFKLALRLRTLQSNGIIMY--TRANPCIILKIVDGKLWFQLDCGSGPGILG 3906
+ + L+L RT Q++G+++ TR I L++ +G + ++ G G+
Sbjct: 1628 HGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVE---GTGLQA 1684
Query: 3907 IS-----GRAVNDGSWHSVFLELNRN----FTSLSLDDSYVERRRAPLYFQTLSTESSIY 3957
S GRA NDG WH L L + LS D Y ++R E ++
Sbjct: 1685 SSLRLEPGRA-NDGDWHHAQLALGASGGPGHAILSFD--YGQQR----------AEGNL- 1730
Query: 3958 FGALVQADNIRSLTDTRVTQ----VLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTE 4013
G + ++ ++T + V GF+GCL V +++ + + S E + + +
Sbjct: 1731 -GPRLHGLHLSNITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQ 1789
Query: 4014 LKLGCVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGG 4073
GC L PD C +PC C+ Y C+C + G NC + C NPC +
Sbjct: 1790 ---GCSL-PDPCDSNPCPANSYCSN-DWDSYSCSCDPGYYGDNCTN---VCDLNPCEHQS 1841
Query: 4074 SCD-----PIGNTFICNCKAGLTGVTCEEDINE-CER 4104
C P G T C C G CE I++ C R
Sbjct: 1842 VCTRKPSAPHGYT--CECPPNYLGPYCETRIDQPCPR 1876
Score = 78.2 bits (191), Expect = 2e-13
Identities = 46/151 (30%), Positives = 63/151 (41%), Gaps = 29/151 (19%)
Query: 4025 CKRSPCQHGGSCTGL---------------------PSGGYQCTCLSQFTGRNCESEITA 4063
C R PC++ C + P GG +C C FTG CE+E+
Sbjct: 1232 CLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDL 1291
Query: 4064 CFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEEDI--NECEREECENGGSCVNVF-GSF 4120
C+ PC G C + C C+ G TG CE C C+NGG+CVN+ G F
Sbjct: 1292 CYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGF 1351
Query: 4121 LCNCTPG-YVGQYCGLRPVVVPNIQAGHSYV 4150
C+C G + YC + P HS++
Sbjct: 1352 KCDCPSGDFEKPYCQVTTRSFP----AHSFI 1378
Score = 43.1 bits (100), Expect = 0.006
Identities = 16/39 (41%), Positives = 22/39 (56%)
Query: 4095 CEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYC 4133
C N C+ C NGG+CVN + +F C C G+ G+ C
Sbjct: 1571 CPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSC 1609
Score = 34.7 bits (78), Expect = 2.2
Identities = 19/58 (32%), Positives = 21/58 (36%), Gaps = 22/58 (37%)
Query: 4098 DINECEREECENGGSCVNVF----------------------GSFLCNCTPGYVGQYC 4133
D N C RE CEN CV+V G C C PG+ G YC
Sbjct: 1228 DDNICLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYC 1285
Score = 34.7 bits (78), Expect = 2.2
Identities = 12/32 (37%), Positives = 16/32 (50%)
Query: 4102 CEREECENGGSCVNVFGSFLCNCTPGYVGQYC 4133
C+ C C N + S+ C+C PGY G C
Sbjct: 1797 CDSNPCPANSYCSNDWDSYSCSCDPGYYGDNC 1828
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 465 bits (1196), Expect = e-130
Identities = 411/1494 (27%), Positives = 666/1494 (44%), Gaps = 169/1494 (11%)
Query: 2706 PSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGG----------- 2754
P F Q Y + E+ A G+ V LR++ + P+ + G
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAV--LRVV-----------AQDPDAGEAGRLVYSLAALMN 369
Query: 2755 -----IFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLND 2809
+F I+ ++G I+ LDRE+ + +V A + T V + V D ND
Sbjct: 370 SRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQ-DHGSPRLSATTMVAVTVADRND 428
Query: 2810 NKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYS-LHSDSQPEKVMEAFNI 2868
+ PVFE + Y + E + G + Q+RA D D N + Y + + AF I
Sbjct: 429 HSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Query: 2869 DSNTGWISTLKDLDHETDPTFTFSVVASDLG-EAFSLSSTALVSVRVTDINDNAPVFAQE 2927
D +G IST +D E ++ V ASD G E S+T V + V D NDNAP F+++
Sbjct: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
Query: 2928 VYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVK 2987
Y V+E P VV ++ DRD D N V Y+I GN RG FA+ + E + V
Sbjct: 549 RYVAQVREDVRPHTVVLRVTATDRD-KDANGLVHYNIISGNSRGHFAIDSLTGE--IQVV 605
Query: 2988 RPLDREEQDIYFLNITATDG----LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIP 3043
PLD E + Y L I A D L + + V D+ND+ P+ + + E+ P
Sbjct: 606 APLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAP 665
Query: 3044 SNKIILKVSAKDADIGSNGYIRYSLYG-SGNSEFFLDPESGELKTLALLDRERIPVYSLM 3102
++ + A DAD G N + YSL G + ++ F ++ +G + LDRE + Y
Sbjct: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
Query: 3103 AKATDGGGR--FCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDI 3160
+A D G +++ + + DVNDN P F+ Y+ + E+ A + V AVD D
Sbjct: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA 785
Query: 3161 GINRKVVYSLAD-SAGGVFSIDSSSGI--IILEQPLDREQQSSYNISVRATDQSPGQSLS 3217
N + Y + + F+I + G+ + L PLD +Q+ + + + A+D++ L
Sbjct: 786 --NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA----LH 839
Query: 3218 SLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRS 3277
V I + D N + PVF+ Y V+V ED G+ ++ + A+ D+G NA ITYL+
Sbjct: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
Query: 3278 GNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDN 3337
Q F+I+ +G I++ LDYE + L + A+D G P + V + + DVNDN
Sbjct: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDN 957
Query: 3338 PPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNG-DRDNEFTVDPVLG 3396
P+F Y+ ++SEDA SV+ + A D D+ NG++ ++ NG D D +FT++P G
Sbjct: 958 APQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSG 1017
Query: 3397 LVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQ 3456
+V+ ++LDRE VS Y L AVD G+P + + ++ + + DVNDN+PVF + ++
Sbjct: 1018 IVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVK 1077
Query: 3457 ENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDP-HGILRSAVVFQHTESL 3515
EN VG+ + Q+ D D N + I+ GN E F +D G L + + +
Sbjct: 1078 ENSIVGSVVAQITAVDPDEGPNA-HIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQ 1136
Query: 3516 EYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEI----FIVTMEDDFPGGVIG 3571
EYV+ VQA + VS + VR+++++ + P +I ++ D FP G+IG
Sbjct: 1137 EYVIVVQATSA---PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIG 1193
Query: 3572 KIHATDQDMYDVLTFAL-KSEQKSLFKVNSHDGKIIALGGLDSGKYV---LNVSVSDGRF 3627
+I A D D+ D L ++ + + L VN G++ LD+ + + + V+V+DG
Sbjct: 1194 RIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLH 1253
Query: 3628 QVPIDVVVHVEQLVHEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLRNAVLTQKQDSLRI 3687
V V+ V + E+L N++T+R EN+ E F+ + F + AVL + + I
Sbjct: 1254 SVTAQCVLRVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVA-AVLATPAEDVFI 1312
Query: 3688 ISIQ---PVAGTNQLDMLF------------AVEMHSSEFYKPAYLIQKLSNARRHLENI 3732
+IQ V GT L++ F A SSE + +++ + A R L ++
Sbjct: 1313 FNIQNDTDVGGT-VLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDV 1371
Query: 3733 MRISAILEKNCSGLDCQE-QHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTC---- 3787
+ + C C+ C L DS A S + + F + +RC C
Sbjct: 1372 LPFD---DNVCLREPCENYMKCVSVLRFDSSAPFLASASTL-FRPIQPIAGLRCRCPPGF 1427
Query: 3788 NGGLCPGSNDPCVEKPCPGDMQCV----SYEASRRP------------------------ 3819
G C D C PC C Y RP
Sbjct: 1428 TGDFCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNG 1487
Query: 3820 ----------FLCQCPPGKL--GECSGHTSLSFAGNSYIKYRLSENSKEEDFKLALRL-- 3865
F CQCP G G + SF +S++ +R + F L L L
Sbjct: 1488 GTCTDAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFR----GLRQRFHLTLSLSF 1543
Query: 3866 RTLQSNGIIMY----TRANPCIILKIVDGKLWFQLDCGSGPGILG--ISGRAVNDGSWHS 3919
T+Q +G++ Y + + L++V G++ G ++ + G ++DG WH+
Sbjct: 1544 ATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPG-GLSDGQWHT 1602
Query: 3920 VFLE-LNRNFT-SLSLDDSYVERRRAPLYFQTLSTESSIYFGAL----------VQADNI 3967
V L N+ T +L + + A L ++ FGA VQ +
Sbjct: 1603 VHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSK 1662
Query: 3968 RSLTDTRVTQVLSGFQGCLDSVILNN-------NELPLQNKRSSFAEVVGLTELKLGCVL 4020
+SL D +L G ++ +++ +L + +R A V GC
Sbjct: 1663 KSL-DLTGPLLLGGVPNLPENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQA 1721
Query: 4021 YPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGS 4074
C PC++ G C+ G + C C F G++C ++T P+ R G+
Sbjct: 1722 KLHFCDSGPCKNSGFCSE-RWGSFSCDCPVGFGGKDC--QLTMAHPHHFRGNGT 1772
Score = 404 bits (1038), Expect = e-111
Identities = 296/967 (30%), Positives = 478/967 (49%), Gaps = 59/967 (6%)
Query: 1559 ANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEA---GNTGNMFK 1615
AN H P F Y+ V E+ A G+AVL+V A D D GE L+Y++ A + +F
Sbjct: 319 ANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 1616 IEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKD 1675
I+P G+I D +M + L + D GSP +SAT +V ++V ++ P F
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 1676 YQAEVNENVDIGTSVILISAIS-----QSTLIYE-----VKDGDINGIFTINPYSGVITT 1725
Y+ + ENV+ G ++ + A + L Y F I+P SG+I+T
Sbjct: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Query: 1726 QKALDYERTSSYQLIIQATNM----AGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEA 1781
+D E SY+L+++A++ ++ V+I ++DENDNAP F +Y + E
Sbjct: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
Query: 1782 APINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDH 1841
+++V L + ATD D + N L+ Y I+ ++ F +DS TG I+ +A LD
Sbjct: 558 VRPHTVV-------LRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
Query: 1842 ETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVE 1901
E + + +D+G P L+ + + +I+V D+ND+ P+F F+ +L +G
Sbjct: 611 EAEREYALRIRAQDAGRPPLSNNTGL-ASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS 669
Query: 1902 VLKVSATDPDSEVPPELTYSLMEGSLD-HFLIDSNSGVLTIKN--NNLSKDHYMLIVKVS 1958
V+ + A D D L YSL + D F+I+S +G +++ + S +HY V+
Sbjct: 670 VIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEAR 729
Query: 1959 D---GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPL 2015
D +++ VT+ V + D+ FT Y ++E+ T V V AV N +
Sbjct: 730 DHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAI 789
Query: 2016 KYSIL--NPGNKFKIKSTSGV-IQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRV 2072
Y I N N+F I + GV + T +P D +++ ++LV+ AS H V +
Sbjct: 790 SYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALH---DHCYVHI 846
Query: 2073 NIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEI 2132
NI D N + PVF Y +V D G+ I ++A D D G N +TY+L+D+ F I
Sbjct: 847 NITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRI 906
Query: 2133 NPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSL--STSVELPITIVNKAMPVFDKPF 2190
+ +SG + L+ + + + Y + I A+D G P +T VE+ + VN P F
Sbjct: 907 DADSGAITLQAPLDYE-DQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
Query: 2191 YTASVNEDIRMNTPILSINATSPEGQG---IIYIIIDG-DPFKQFNIDFDTGVLKVVSPL 2246
YT V+ED T +L I+AT + + Y +G D F I+ +G+++ V L
Sbjct: 966 YTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRL 1025
Query: 2247 DYEVTSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTP 2305
D E S Y+LT A D + R V++ ++V DVNDN P+F + + E S++G+
Sbjct: 1026 DREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSV 1085
Query: 2306 VLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVR 2365
V Q+ ++D D N + YQIV+ N + F +D SG + LD+E Q + V+
Sbjct: 1086 VAQITAVDPDEGPNAHIMYQIVEG--NIPELFQMDIFSGELTALIDLDYEARQEYVIVVQ 1143
Query: 2366 SIDSGFPSLSSEVLVHIYISDVNDNPPVFN--QLIYESYV---SELAPRGHFVTCVQASD 2420
+ + L S VH+ + D NDN PV N Q+++ +YV S+ P G + + A D
Sbjct: 1144 ATSA---PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYD 1199
Query: 2421 ADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTA 2480
D S D L YS GN+ +++ SG + LS + S+ V+V+DGL + TA
Sbjct: 1200 PDVS--DHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTA 1257
Query: 2481 QVHIRVL 2487
Q +RV+
Sbjct: 1258 QCVLRVV 1264
Score = 376 bits (965), Expect = e-103
Identities = 304/972 (31%), Positives = 467/972 (48%), Gaps = 71/972 (7%)
Query: 1041 PYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIR---DGSGLGRFSIDDES 1097
P FP + V EN GT+VL+V A+D D+G G + YS+ + L FSID +S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 1098 GVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVV 1157
G+I A LDRE+M ++L V A D G L +T V + V D ND++P+ + Y +
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
Query: 1158 MENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNP------QNFFAINIKTGLITTTSRK 1211
EN + ++Q++A D D+ N L YR G P F I+ ++GLI+T+ R
Sbjct: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFV-GPPAARAAAAAAFEIDPRSGLISTSGR- 500
Query: 1212 LDREQQAEHFLEVTVTDGG--PSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRK 1269
+DRE + L V +D G P P+ +T+ V + VLDENDN PQF EK Y ++ R+
Sbjct: 501 VDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV--REDV 558
Query: 1270 KRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTG--MVSSRKQFTAGSYDIL 1327
+ + R A DRD+ N + Y+I+ GN G F ID TG V + F A L
Sbjct: 559 RPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYAL 618
Query: 1328 TIKAVDNGRPQKSST---ARLHIEWIKKPPPSPIPLTFDEPFYNFTVMES----DRVTEI 1380
I+A D GRP S+ A + + I IP+ PF +V+E+ V I
Sbjct: 619 RIRAQDAGRPPLSNNTGLASIQVVDIN----DHIPIFVSTPF-QVSVLENAPLGHSVIHI 673
Query: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
V + N L + + G D+ F G + ++ PLD E Y VE D +
Sbjct: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGS 733
Query: 1441 ---VAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTV 1497
A V + VLD NDN PEF+ Y + ++ED T ++ + A DRD +SY +
Sbjct: 734 PPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQI 793
Query: 1498 HSSIDSISMRKFRIDPSTGV--LYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVN 1555
+ +F I GV + A LD++ + L + D+ + V +N
Sbjct: 794 ---TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRAL---HDHCYVHIN 847
Query: 1556 VEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFK 1615
+ DAN H P F + Y SV E +GS ++ ++A D D GENA + Y +E + F+
Sbjct: 848 ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE--DNLPQFR 905
Query: 1616 IEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKD 1675
I+ G IT+ D + L+I D G P + T V + V +++ P+F+
Sbjct: 906 IDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
Query: 1676 YQAEVNENVDIGTSVILISAISQST-----LIYEVKDG-DINGIFTINPYSGVITTQKAL 1729
Y V+E+ TSV+ ISA + + Y ++G D +G FTI P SG++ T + L
Sbjct: 966 YTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRL 1025
Query: 1730 DYERTSSYQLIIQATNMAGMASNATVNIQIV--DENDNAPVFLFSQYSGSLSEAAPINSI 1787
D E S Y+L A + V+IQ++ D NDNAPVF ++ + E + + S+
Sbjct: 1026 DREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSV 1085
Query: 1788 VRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHF 1847
V I A D D NA ++YQIVE + F +D +G + + +LD+E A
Sbjct: 1086 VAQ-------ITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYE--ARQ 1136
Query: 1848 HFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFT--QAVFETIL--LLPTYVGVEVL 1903
+ + V+ + +P + S V++ + D NDN PV Q +F + T+ +
Sbjct: 1137 EYVIVVQATSAPLV---SRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIG 1193
Query: 1904 KVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTI--KNNNLSKDHYMLIVKVSDG 1960
++ A DPD V L YS G+ L +++ SG L + K +N ++V V+DG
Sbjct: 1194 RIPAYDPD--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG 1251
Query: 1961 KFYSTSMVTIMV 1972
T+ + V
Sbjct: 1252 LHSVTAQCVLRV 1263
Score = 367 bits (943), Expect = e-100
Identities = 290/980 (29%), Positives = 447/980 (45%), Gaps = 70/980 (7%)
Query: 824 ANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLT-----DTQQFA 878
A + P F Q +Y + E+ GT +++V A+D D G G + YS+ + F+
Sbjct: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 879 INSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIP 938
I+ +G++ A LDRES + L++ A+D +L + + V + D ND SP F
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQD--HGSPRLSATTMVAVTVADRNDHSPVFEQ 435
Query: 939 SSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR------FEIDKASGAI 992
+ Y + E++ G I L D D +RY V R FEID SG I
Sbjct: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Query: 993 RLSKELDYEKQQFYNLTVRAKDKGR-PVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGS 1051
S +D E + Y L V A D+G+ P S+ V + V+D N+N P F + V
Sbjct: 496 STSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDN--APQFSEKRYVAQ 553
Query: 1052 VKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETM 1111
V+E+ R T VL+VTA D D +G + Y+I G+ G F+ID +G I LD E
Sbjct: 554 VREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAE 613
Query: 1112 GSYWLTVYATDRGVVPL-YSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI 1170
Y L + A D G PL +T I+V D+ND+ P+ + V+EN+P SVI I
Sbjct: 614 REYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673
Query: 1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG 1230
QA D D N +L Y +T P F IN TG + + S LDRE +F V D G
Sbjct: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWV-SVSGPLDRESVEHYFFGVEARDHG 732
Query: 1231 PSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAE 1290
P ++ V V VLD NDN+P+F K Y ++L E G + A DRD N+
Sbjct: 733 SPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNE--DAAVGTSVVSVTAVDRD--ANSA 788
Query: 1291 ISYSIVDGNDDGKFFIDPKTGM----VSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLH 1346
ISY I GN +F I + G+ ++ + Y L + A D +H
Sbjct: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVH 845
Query: 1347 IEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAF 1406
I P+ F Y+ +V E + + V+S D VG N +
Sbjct: 846 INITDANTHRPV---FQSAHYSVSVNEDRPMGSTIVVISASD-------DDVGENARITY 895
Query: 1407 DAEKGV---------GTIVIAKPLDAEQRSIYNMSVEVTDG---TNVAVTQVFIKVLDNN 1454
E + G I + PLD E + Y +++ D T V + V D N
Sbjct: 896 LLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVN 955
Query: 1455 DNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD--EKHKLSYTVHSSIDSISMRKFRID 1512
DN P+F +Y +SED P T +LQI ATDRD ++ YT + D F I+
Sbjct: 956 DNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDG--DFTIE 1013
Query: 1513 PSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYE 1572
P++G++ T RLD EA + L D+ P R + V V+D ND++P F +E
Sbjct: 1014 PTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFE 1073
Query: 1573 ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMT 1632
V E++ +GS V Q+TA+D D+G NA ++Y I GN +F+++ G +T + D
Sbjct: 1074 VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYE 1133
Query: 1633 TMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL 1692
++V+ ++ T S P+ + A V + + +++ P + ++Q N V +
Sbjct: 1134 ARQEYVIVVQAT---SAPLVSRATVHVRLVDQNDNSP--VLNNFQILFNNYVSNRSDTFP 1188
Query: 1693 ISAISQ---------STLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQA 1743
I + L Y + G+ + +N SG + + LD R +++
Sbjct: 1189 SGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTV 1248
Query: 1744 TN-MAGMASNATVNIQIVDE 1762
T+ + + + + + I+ E
Sbjct: 1249 TDGLHSVTAQCVLRVVIITE 1268
Score = 365 bits (938), Expect = e-100
Identities = 275/852 (32%), Positives = 416/852 (48%), Gaps = 79/852 (9%)
Query: 420 FKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG-----DLKAQVTISIEDANDHTPEFQQ 474
F I+P+SGLI TA L+ E + L VT ++ V +++ D NDH+P F+Q
Sbjct: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
Query: 475 PLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIA------SLNLLPFVINQFTGVI 528
Y + E+V G +L + A+D D N + Y + F I+ +G+I
Sbjct: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Query: 529 STTEELDFESSPEIYRFIVRASDWGS-PYRHESEVNVTIRIGNVNDNSPLFEKVACQGVI 587
ST+ +D E E Y +V ASD G P + V V I + + NDN+P F + +
Sbjct: 496 STSGRVDREHM-ESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQV 554
Query: 588 SYDFPVGGHITAVSAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIK 645
D + V+A D D+ LV Y IISGN G F ++ +G +Q+ L +
Sbjct: 555 REDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAER 614
Query: 646 NGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGK 705
+ALRI A D P+S N + +V
Sbjct: 615 E--YALRIRAQDAGR--PPLSNNTGLASIQV----------------------------- 641
Query: 706 LNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTI 765
IN P F S P V+V E+ P+G +++ I+A DAD G N ++ +++
Sbjct: 642 ----------VDINDHIPIF-VSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL 690
Query: 766 SDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDAN 825
+ D+ F I+ TG + V P+DRE + Y + D G+P S+ +T+ V D N
Sbjct: 691 TGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVN 750
Query: 826 DNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAINS-- 881
DN P F Y + + E + +GT ++ V A D+D +N ++Y + +FAI++
Sbjct: 751 DNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQG 808
Query: 882 STGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSY 941
G+V +A LD + + + L + A D+A L + + + D N P F + Y
Sbjct: 809 GVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHINITDANTHRPVFQSAHY 863
Query: 942 SVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYE 1001
SV V ED P+G+ I + D D+G ++ Y L+ D +F ID SGAI L LDYE
Sbjct: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDNLPQFRIDADSGAITLQAPLDYE 922
Query: 1002 KQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTS 1061
Q Y L + A+D G P + ++VEV V DVN+N P F G V E++ TS
Sbjct: 923 DQVTYTLAITARDNGIP-QKADTTYVEVMVNDVNDN--APQFVASHYTGLVSEDAPPFTS 979
Query: 1062 VLQVTARDEDSGRDGEIQYSIRDG-SGLGRFSIDDESGVITAADILDRETMGSYWLTVYA 1120
VLQ++A D D+ +G +QY+ ++G G G F+I+ SG++ LDRE + Y LT YA
Sbjct: 980 VLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA 1039
Query: 1121 TDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSN 1180
DRGV PL + + + + V+DVNDNAP+ + V ENS V QI A DPD N
Sbjct: 1040 VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPN 1099
Query: 1181 EKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWV 1240
+ Y+I GN F ++I +G +T LD E + E+ + V T +P S V
Sbjct: 1100 AHIMYQIVEGNIPELFQMDIFSGELTALI-DLDYEARQEYVIVVQATS---APLVSRATV 1155
Query: 1241 VVQVLDENDNKP 1252
V+++D+NDN P
Sbjct: 1156 HVRLVDQNDNSP 1167
Score = 362 bits (930), Expect = 4e-99
Identities = 301/1017 (29%), Positives = 476/1017 (46%), Gaps = 101/1017 (9%)
Query: 465 ANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASL----NLLPFV 520
AN H P+F Q Y V E+ GT+VL V A D D GE G + YS+A+L +L F
Sbjct: 319 ANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 521 INQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEK 580
I+ +G+I T LD ES Y V A D GSP R + V + + + ND+SP+FE+
Sbjct: 378 IDPQSGLIRTAAALDRESMERHY-LRVTAQDHGSP-RLSATTMVAVTVADRNDHSPVFEQ 435
Query: 581 VACQGVISYDFPVGGHITAVSAIDID--ELELVKYKIIS-----GNELGFFYLNPDSGVL 633
+ + + G I + A D D ++Y+ + F ++P SG++
Sbjct: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLI 495
Query: 634 QLKKSLTNSGIKNGNFALRITATDGENLADPMS----INISVLHGKVSSKSFSCRETRVA 689
+ ++ ++ L + A+D P S ++I+VL ++ FS + VA
Sbjct: 496 STSGRVDREHME--SYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFS-EKRYVA 552
Query: 690 QKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIK 749
Q V+ED+ +L++
Sbjct: 553 Q--------------------------------------------VREDVRPHTVVLRVT 568
Query: 750 AYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNP 809
A D D NG V + I GN+ F ID TG+++V+ P+D E Y L I D G P
Sbjct: 569 ATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRP 628
Query: 810 QKS-SWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTY 868
S + L +I V D ND+ P+F+ + V++LE++ +G +I ++A D D G N + Y
Sbjct: 629 PLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEY 688
Query: 869 S---VLTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVF 925
S V DT F INS+TG V V+ LDRES +Y +EARD + VT+ V
Sbjct: 689 SLTGVAPDT-PFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVL 747
Query: 926 LDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFE 984
DVND P F Y +++ ED VGT + + D D + Y + + RF
Sbjct: 748 --DVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFA 803
Query: 985 IDKASGA--IRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPY 1042
I G + L+ LDY++++++ L + A D+ +L +V + + D N H P
Sbjct: 804 ISTQGGVGLVTLALPLDYKQERYFKLVLTASDR----ALHDHCYVHINITDA--NTHRPV 857
Query: 1043 FPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITA 1102
F SV E+ +G++++ ++A D+D G + I Y + D L +F ID +SG IT
Sbjct: 858 FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED--NLPQFRIDADSGAITL 915
Query: 1103 ADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSP 1162
LD E +Y L + A D G+ T V + V DVNDNAP Y +V E++P
Sbjct: 916 QAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAP 975
Query: 1163 KDVSVIQIQAEDPDSSSNEKLTYRITSG-NPQNFFAINIKTGLITTTSRKLDREQQAEHF 1221
SV+QI A D D+ +N ++ Y +G + F I +G++ T R+LDRE + +
Sbjct: 976 PFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV-RRLDREAVSVYE 1034
Query: 1222 LEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAF 1281
L D G P ++ + + V V D NDN P FP + +++++ E G + + A
Sbjct: 1035 LTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV--GSVVAQITAV 1092
Query: 1282 DRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSS--RKQFTAGSYDILTIKAVDNGRPQK 1339
D DEGPNA I Y IV+GN F +D +G +++ + A ++ ++A
Sbjct: 1093 DPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS---APL 1149
Query: 1340 SSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTP-----LW 1394
S A +H+ + + SP+ F F N+ SD T G++ PA P L+
Sbjct: 1150 VSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSD--TFPSGIIGRIPAYDPDVSDHLF 1207
Query: 1395 FDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVL 1451
+ GN + G + +++ LD + + +M V VTDG + Q ++V+
Sbjct: 1208 YSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVV 1264
Score = 339 bits (869), Expect = 4e-92
Identities = 283/957 (29%), Positives = 450/957 (47%), Gaps = 60/957 (6%)
Query: 2392 PVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSI---LSGNDRTSFLMDSKS 2448
P F Q Y++ V E G V V A D D+ + RL YS+ ++ F +D +S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 2449 GVI-TLSNHRKQRMEPLYSLNVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTYVAE 2504
G+I T + ++ ME Y L V+ D ++T V + V N +SP F Q+ Y
Sbjct: 383 GLIRTAAALDRESMERHY-LRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441
Query: 2505 VRENVAAGTKVIHVRATDGDPGTYGQISYAIIND-----FAKDRFLIDS-NGQVITTERL 2558
+RENV G ++ +RATDGD + Y + A F ID +G + T+ R+
Sbjct: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501
Query: 2559 DREN--PLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRG 2616
DRE+ E V + + G R+ V + V+DENDNAPQF Y A VR DV
Sbjct: 502 DREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPH 561
Query: 2617 HLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSF 2676
+V +V A D D AN + Y++ S S ID G + + +
Sbjct: 562 TVVLRVTATDRDKDANGLVHYNIISGNS---RGHFAIDSLTGEIQVVAPLDFEAEREYAL 618
Query: 2677 FVKAVDGG-IPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPS 2735
++A D G P+ ++ I V+ +P F + + ++ E+ +G +V ++ + +
Sbjct: 619 RIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDA 678
Query: 2736 ---QNVWFS-TVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDK 2791
+N ++ G P+ FVI TG + + LDRE+ + F V A
Sbjct: 679 DHGENARLEYSLTGVAPDTP----FVINSATGWVSVSGPLDRESVEHYFFGVEAR-DHGS 733
Query: 2792 VDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTY 2851
+ + V + VLD+NDN+P F Y + E VGT + V A+D D AN ++Y
Sbjct: 734 PPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISY 791
Query: 2852 SLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVS 2911
+ + + A + G ++ LD++ + F + ASD +L V
Sbjct: 792 QITGGNTRNRF--AISTQGGVGLVTLALPLDYKQERYFKLVLTASDR----ALHDHCYVH 845
Query: 2912 VRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRG 2971
+ +TD N + PVF Y +V E P G + V+S D D + N +++Y + P+
Sbjct: 846 INITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGE-NARITYLLEDNLPQF 904
Query: 2972 RFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQA---MVEVSVSDVNDNSPV 3028
R + + ++ PLD E+Q Y L ITA D +A VEV V+DVNDN+P
Sbjct: 905 R----IDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQ 960
Query: 3029 CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYG--SGNSEFFLDPESGELK 3086
YT L+ ED P +L++SA D D +NG ++Y+ G+ +F ++P SG ++
Sbjct: 961 FVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVR 1020
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQS--NIHLILEDVNDNPPVFSSDHYNTCVYENT 3144
T+ LDRE + VY L A A D G ++ +I ++++DVNDN PVF ++ + V EN+
Sbjct: 1021 TVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENS 1080
Query: 3145 ATKALLTRVQAVDPDIGINRKVVYSLAD-SAGGVFSIDSSSGIIILEQPLDREQQSSYNI 3203
+++ ++ AVDPD G N ++Y + + + +F +D SG + LD E + Y I
Sbjct: 1081 IVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVI 1140
Query: 3204 SVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYL----VTVPEDTSPGTQVLAVF 3259
V+AT L S TV + ++D NDN PV L V+ DT P + +
Sbjct: 1141 VVQAT----SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIP 1196
Query: 3260 ATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDG 3316
A D+ + + Y GNE +N +G + +S LD ++V DG
Sbjct: 1197 AYDPDVSDH--LFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG 1251
Score = 332 bits (850), Expect = 7e-90
Identities = 266/938 (28%), Positives = 449/938 (47%), Gaps = 64/938 (6%)
Query: 1252 PQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSI---VDGNDDGKFFIDP 1308
PQFP+ YQ +PE + G + R A D D G + YS+ ++ F IDP
Sbjct: 323 PQFPQYNYQTLVPENEAA--GTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDP 380
Query: 1309 KTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPF 1366
++G++ + S + L + A D+G P+ S+T + + + SP+ F++
Sbjct: 381 QSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPV---FEQAQ 437
Query: 1367 YNFTVMESDR----VTEIVGVVSVQPANTPLWFDIVG-----GNFDSAFDAEKGVGTIVI 1417
Y T+ E+ + ++ P N L + VG +AF+ + G I
Sbjct: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Query: 1418 AKPLDAEQRSIYNMSVEVTD-----GTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISED 1472
+ +D E Y + VE +D G A +V I VLD NDN P+FS+ Y + ED
Sbjct: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
Query: 1473 VLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMR-KFRIDPSTGVLYTAERLDHEAQDK 1531
V P T +L++ ATDRD+ + VH +I S + R F ID TG + LD EA+ +
Sbjct: 558 VRPHTVVLRVTATDRDKD--ANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE 615
Query: 1532 HILNIMVRDQ-EFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
+ L I +D P N + V D NDH P F + ++ SV E+A LG +V+ + A
Sbjct: 616 YALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQA 675
Query: 1591 LDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPP 1650
+D D GENA L Y++ F I G +++ D ++ + ++ D GSPP
Sbjct: 676 VDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPP 735
Query: 1651 MSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI---SQSTLIYEVKD 1707
+SA+A V ++V +++ P+F K+Y +NE+ +GTSV+ ++A+ + S + Y++
Sbjct: 736 LSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITG 795
Query: 1708 GDINGIFTINPYSGV--ITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDN 1765
G+ F I+ GV +T LDY++ ++L++ A++ A + + V+I I D N +
Sbjct: 796 GNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHDHCYVHINITDANTH 854
Query: 1766 APVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFT 1825
PVF + YS S++E P+ S + +VI A+D D NA + Y + ++ + F
Sbjct: 855 RPVFQSAHYSVSVNEDRPMGSTI-------VVISASDDDVGENARITYLLEDNLPQ--FR 905
Query: 1826 VDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQ 1885
+D+ +GAI A LD+E + + RD+G PQ + VEV V DVNDN P F
Sbjct: 906 IDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEV--MVNDVNDNAPQFVA 963
Query: 1886 AVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEG--SLDHFLIDSNSGVL-TIK 1942
+ + ++ VL++SATD D+ + Y+ G F I+ SG++ T++
Sbjct: 964 SHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVR 1023
Query: 1943 N-NNLSKDHYMLIVKVSD---GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNI 1998
+ + Y L D + + +MV++ D+ F + + EN+
Sbjct: 1024 RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVG 1083
Query: 1999 TKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELYELVV 2054
+ VA + AV N + Y I+ N F++ SG + T + D E ++ Y +VV
Sbjct: 1084 SVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGEL-TALIDLDYEARQEYVIVV 1142
Query: 2055 EASRELDHLRVARVVVRVNIEDINDNSPVF----VGLPYYAAVQVDAEPGTLIYQVTAID 2110
+A+ V+R V V + D NDNSPV + Y + + D P +I ++ A D
Sbjct: 1143 QAT---SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYD 1199
Query: 2111 KDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSD 2148
D + ++ ++ +N SG + L +++
Sbjct: 1200 PDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNN 1237
Score = 332 bits (850), Expect = 7e-90
Identities = 257/956 (26%), Positives = 456/956 (47%), Gaps = 53/956 (5%)
Query: 735 VKEDLPVGANILKIKAYDADSGFNGKVLFTIS---DGNTDSCFNIDMETGQLKVLMPMDR 791
V E+ G +L++ A D D+G G+++++++ + + F+ID ++G ++ +DR
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
Query: 792 EHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEII 851
E + + L +T D G+P+ S+ ++ + V D ND+SPVF Q Y + E+ G I+
Sbjct: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL 453
Query: 852 QVEARDKDLGSNGEVTYSVL-------TDTQQFAINSSTGIVYVADQLDRESKANYSLKI 904
Q+ A D D N + Y + F I+ +G++ + ++DRE +Y L +
Sbjct: 454 QLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVV 513
Query: 905 EARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPD 964
EA D+ + + V + + + D ND +P F Y +V ED+ TV+ + D D
Sbjct: 514 EASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRD 573
Query: 965 LGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSS 1023
G V Y++++ + G F ID +G I++ LD+E ++ Y L +RA+D GRP ++
Sbjct: 574 KDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNN 633
Query: 1024 VSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIR 1083
++VVD+N+ H P F SV EN+ +G SV+ + A D D G + ++YS+
Sbjct: 634 TGLASIQVVDIND--HIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLT 691
Query: 1084 DGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVND 1143
+ F I+ +G ++ + LDRE++ Y+ V A D G PL ++ V + V DVND
Sbjct: 692 GVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVND 751
Query: 1144 NAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTG 1203
N P + Y+ + E++ SV+ + A D D +N ++Y+IT GN +N FAI+ + G
Sbjct: 752 NRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGG 809
Query: 1204 L-ITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIK 1262
+ + T + LD +Q+ L +T +D +V + + D N ++P F Y +
Sbjct: 810 VGLVTLALPLDYKQERYFKLVLTASD---RALHDHCYVHINITDANTHRPVFQSAHYSVS 866
Query: 1263 LPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFT 1320
+ E + G I A D D G NA I+Y + D +F ID +G ++ + +
Sbjct: 867 VNE--DRPMGSTIVVISASDDDVGENARITYLLEDNLP--QFRIDADSGAITLQAPLDYE 922
Query: 1321 AGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
L I A DNG PQK+ T ++E + P + ++ T +
Sbjct: 923 DQVTYTLAITARDNGIPQKADTT--YVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSV 980
Query: 1381 VGVVSVQ---PANTPLWFDIVGG-NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVT 1436
+ + + AN + + G + D F E G + + LD E S+Y ++
Sbjct: 981 LQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAV 1040
Query: 1437 D-GTNVAVTQVFIKVL--DNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKL 1493
D G T V I+V+ D NDN P F ++V + E+ + + + QI A D DE
Sbjct: 1041 DRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPN- 1099
Query: 1494 SYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVI 1553
++ ++ ++ F++D +G L LD+EA+ ++++ + R A V
Sbjct: 1100 AHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSR---ATVH 1156
Query: 1554 VNVEDANDHSPYFTN--------PLYEASVFESAALGSAVLQVTALDKDKGENAELIYTI 1605
V + D ND+SP N + F S +G ++ A D D ++ L Y+
Sbjct: 1157 VRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIG----RIPAYDPDVSDH--LFYSF 1210
Query: 1606 EAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661
E GN + + G + + ++ D + + VTD G ++A ++R+ +
Sbjct: 1211 ERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTD-GLHSVTAQCVLRVVI 1265
Score = 330 bits (847), Expect = 2e-89
Identities = 289/979 (29%), Positives = 439/979 (44%), Gaps = 57/979 (5%)
Query: 1654 TAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST-----LIYEVK-- 1706
T+ R + N HP+F +YQ V EN GT+V+ + A L+Y +
Sbjct: 308 TSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAAL 367
Query: 1707 -DGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNAT--VNIQIVDEN 1763
+ +F+I+P SG+I T ALD E + L + A + +AT V + + D N
Sbjct: 368 MNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
Query: 1764 DNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV-----ES 1818
D++PVF +QY +L E + L +RATD D+ NA L Y+ V +
Sbjct: 428 DHSPVFEQAQYRETLRENVEEGYPI-------LQLRATDGDAPPNANLRYRFVGPPAARA 480
Query: 1819 TAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVND 1878
A F +D +G I T +D E + + V D G + V V+I V D ND
Sbjct: 481 AAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDEND 540
Query: 1879 NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEG-SLDHFLIDSNSG 1937
N P F++ + + VL+V+ATD D + + Y+++ G S HF IDS +G
Sbjct: 541 NAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTG 600
Query: 1938 VLTIKN--NNLSKDHYMLIVKVSDGK----FYSTSMVTIMVKEAMDSGLHFTQSFYSTSI 1991
+ + + ++ Y L ++ D +T + +I V + D F + + S+
Sbjct: 601 EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSV 660
Query: 1992 SENNTNITKVAIVNAVG--NRLNEPLKYSILN--PGNKFKIKSTSGVIQTTGVPFDREEQ 2047
EN V + AV + N L+YS+ P F I S +G + +G P DRE
Sbjct: 661 LENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSG-PLDRESV 719
Query: 2048 ELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVT 2107
E Y VEA A V V + D+NDN P F Y+ + DA GT + VT
Sbjct: 720 EHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVT 779
Query: 2108 AIDKDKGPNGEVTYVLQ--DDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGK 2165
A+D+D N ++Y + + F I+ G ++ A D Y +L
Sbjct: 780 AVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA 837
Query: 2166 PSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP---EGQGIIYII 2222
V + IT N PVF Y+ SVNED M + I+ I+A+ E I Y++
Sbjct: 838 LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL 897
Query: 2223 IDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVT-VDLLVNDVN 2281
D P QF ID D+G + + +PLDYE Y L I A D +A+ T V+++VNDVN
Sbjct: 898 EDNLP--QFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVN 955
Query: 2282 DNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDS 2341
DN P F Y +SE + T VLQ+ + D D+ N V Y Q+ + F I+
Sbjct: 956 DNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTF-QNGEDGDGDFTIEP 1014
Query: 2342 SSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYES 2401
+SG++ T R LD E V L ++D G P L + V + + + DVNDN PVF +E
Sbjct: 1015 TSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEV 1074
Query: 2402 YVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRM 2461
V E + G V + A D D + Y I+ GN F MD SG +T
Sbjct: 1075 RVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA 1134
Query: 2462 EPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQ-----STYVAEVRENVAAGTKVI 2516
Y + V + S A VH+R++ N SP + + YV+ + +G I
Sbjct: 1135 RQEYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG---I 1191
Query: 2517 HVRATDGDPGTYGQISYAIINDFAKDRFLID-SNGQVITTERLDRENPLEGDVSIFVRAL 2575
R DP + Y+ +++ ++G++ + +LD PL S+ V
Sbjct: 1192 IGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLV--ASMLVTVT 1249
Query: 2576 DG-GGRTTFCTVRVIVVDE 2593
DG T C +RV+++ E
Sbjct: 1250 DGLHSVTAQCVLRVVIITE 1268
Score = 321 bits (822), Expect = 1e-86
Identities = 275/949 (28%), Positives = 435/949 (45%), Gaps = 91/949 (9%)
Query: 326 IKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSI 385
I+ +D ES Y L + A+D GSP+ + D P+ FE+ Y ++
Sbjct: 385 IRTAAALDRESMERHY-LRVTAQDHGSPRLSATTMVAVTVADRNDHSPV-FEQAQYRETL 442
Query: 386 SEFSPPGVVVAIVKLS----PEPIDVEYKL-----SPGEDAVYFKINPRSGLIVTARPLN 436
E G + ++ + P ++ Y+ + A F+I+PRSGLI T+ ++
Sbjct: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 502
Query: 437 TVKKEVYKLEVTNKEGDLK-------AQVTISIEDANDHTPEFQQPLYDAYVNESVPVGT 489
E Y+L V + + +V I++ D ND+ P+F + Y A V E V T
Sbjct: 503 REHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562
Query: 490 SVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVISTTEELDFESSPEIYRFIVR 548
VL V+A+D+DK NG + Y+I S N F I+ TG I LDFE+ E Y +R
Sbjct: 563 VVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE-YALRIR 621
Query: 549 ASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDEL 608
A D G P + +I++ ++ND+ P+F Q + + P+G + + A+D D
Sbjct: 622 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
Query: 609 E--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMS 666
E ++Y + F +N +G + + L +++ F + L+ S
Sbjct: 682 ENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASAS 741
Query: 667 INISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFD 726
+ ++VL + F+ +E + +LN
Sbjct: 742 VTVTVLDVNDNRPEFTMKEYHL----------------RLN------------------- 766
Query: 727 KSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLK 784
ED VG +++ + A D D+ N + + I+ GNT + F I + G +
Sbjct: 767 ----------EDAAVGTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGVGLVT 814
Query: 785 VLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESS 844
+ +P+D + + L +T D + IN+ DAN + PVF YSV++ E
Sbjct: 815 LALPLDYKQERYFKLVLTASDRALHDHC---YVHINITDANTHRPVFQSAHYSVSVNEDR 871
Query: 845 GIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKI 904
+G+ I+ + A D D+G N +TY + + QF I++ +G + + LD E + Y+L I
Sbjct: 872 PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931
Query: 905 EARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPD 964
ARD Q ++V ++DVND +P F+ S Y+ V ED P T + + D D
Sbjct: 932 TARDNGIP--QKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRD 989
Query: 965 LGLGGQVRYSLVN--DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLS 1022
G+V+Y+ N D +G F I+ SG +R + LD E Y LT A D+G P +
Sbjct: 990 AHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRT 1049
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSI 1082
VS ++V V DVN+N P FP VKENS +G+ V Q+TA D D G + I Y I
Sbjct: 1050 PVS-IQVMVQDVNDN--APVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQI 1106
Query: 1083 RDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVN 1142
+G+ F +D SG +TA LD E Y + V AT PL S V++ + D N
Sbjct: 1107 VEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS---APLVSRATVHVRLVDQN 1163
Query: 1143 DNAPLTS--EPIYYPVVMENSPKDVSVI--QIQAEDPDSSSNEKLTYRITSGNPQNFFAI 1198
DN+P+ + + ++ V S S I +I A DPD S + L Y GN +
Sbjct: 1164 DNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDH--LFYSFERGNELQLLVV 1221
Query: 1199 NIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDE 1247
N +G + SRKLD + + VTVTDG S + VV + +E
Sbjct: 1222 NQTSGELRL-SRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVIITEE 1269
Score = 293 bits (750), Expect = 3e-78
Identities = 272/996 (27%), Positives = 431/996 (43%), Gaps = 103/996 (10%)
Query: 156 PLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF-----KNKVDLFSVHPTS 210
P F Y + E+ T+V +V A D D G G Y ++LFS+ P S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 211 GVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT 270
G+I + L+ + R+ L + A D +G+ +S+T + V + N+H+P
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQD-----HGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 271 HVPFSLEK-EPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKER 329
+ E E Y ++ + D A G P A ++I R
Sbjct: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPP------AARAAAAAAFEIDPR 491
Query: 330 K-------QIDWESFPYGYNLTLQAKDKG-SPQKCSALKAVYIGNPTRDTVPIRFEKEVY 381
++D E Y L ++A D+G P SA V+I + +F ++ Y
Sbjct: 492 SGLISTSGRVDREHME-SYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRY 550
Query: 382 DVSISEFSPPGVVVAIVKLSPEPID----VEYKLSPGEDAVYFKINPRSGLIVTARPLNT 437
+ E P VV V + D V Y + G +F I+ +G I PL+
Sbjct: 551 VAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDF 610
Query: 438 VKKEVYKLEVTNKE------GDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSV 491
+ Y L + ++ + +I + D NDH P F + V E+ P+G SV
Sbjct: 611 EAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
Query: 492 LTVSASDKDKGENGYITYSIASLNL-LPFVINQFTGVISTTEELDFESSPEIYRFIVRAS 550
+ + A D D GEN + YS+ + PFVIN TG +S + LD E S E Y F V A
Sbjct: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRE-SVEHYFFGVEAR 729
Query: 551 DWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELEL 610
D GSP S +VT+ + +VNDN P F ++ D VG + +V+A+D D
Sbjct: 730 DHGSPPLSAS-ASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSA 788
Query: 611 VKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINIS 670
+ Y+I GN F ++ GV + +L + F L +TA+D L D ++I+
Sbjct: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD-RALHDHCYVHIN 847
Query: 671 VLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFP 730
+ N P F +
Sbjct: 848 IT--------------------------------------------DANTHRPVFQSAHY 863
Query: 731 SDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMD 790
S V+V ED P+G+ I+ I A D D G N ++ + + D F ID ++G + + P+D
Sbjct: 864 S-VSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--FRIDADSGAITLQAPLD 920
Query: 791 REHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEI 850
E Y L IT D G PQK+ + + V D NDN+P F+ Y+ + E + T +
Sbjct: 921 YEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSV 980
Query: 851 IQVEARDKDLGSNGEVTYSVLTDTQ---QFAINSSTGIVYVADQLDRESKANYSLKIEAR 907
+Q+ A D+D +NG V Y+ F I ++GIV +LDRE+ + Y L A
Sbjct: 981 LQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAV 1040
Query: 908 DKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
D+ L + V+++V + DVND +P F + V+V E+ VG+V+A + DPD G
Sbjct: 1041 DRGV--PPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGP 1098
Query: 968 GGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSF 1026
+ Y +V + F++D SG + +LDYE +Q Y + V+A L S +
Sbjct: 1099 NAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS----APLVSRAT 1154
Query: 1027 VEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAR--DEDSGRDGEIQYSIRD 1084
V V +VD N+N +P +F ++ + ++R T + R D + YS
Sbjct: 1155 VHVRLVDQNDN--SPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFER 1212
Query: 1085 GSGLGRFSIDDESGVITAADILD--RETMGSYWLTV 1118
G+ L ++ SG + + LD R + S +TV
Sbjct: 1213 GNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTV 1248
Score = 241 bits (615), Expect = 1e-62
Identities = 248/957 (25%), Positives = 419/957 (43%), Gaps = 106/957 (11%)
Query: 114 SAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTP 172
+A L+RE + + L V G L A T V + V D ND P+F Y T+ E+
Sbjct: 388 AAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVE 447
Query: 173 LRTSVAQVTATDADIGSNGEFYYYFKN-------KVDLFSVHPTSGVISLSGRLNYDEKN 225
+ Q+ ATD D N Y F F + P SG+IS SGR++ +
Sbjct: 448 EGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHME 507
Query: 226 RYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAV- 284
Y+L + A D+G + S+T ++++ + N++AP +V E + V
Sbjct: 508 SYELVVEASDQGQE---PGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVV 564
Query: 285 --VTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYN 342
VT D D ANG + +I++G+ F + +I+ +D+E+ Y
Sbjct: 565 LRVTATDRDKDANGLVH-YNIISGNSRGHFAIDS-----LTGEIQVVAPLDFEA-EREYA 617
Query: 343 LTLQAKDKGSP--QKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVV----A 396
L ++A+D G P + L ++ + + D +PI F + VS+ E +P G V A
Sbjct: 618 LRIRAQDAGRPPLSNNTGLASIQVVD-INDHIPI-FVSTPFQVSVLENAPLGHSVIHIQA 675
Query: 397 IVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG---- 452
+ E +EY L+ F IN +G + + PL+ E Y V ++
Sbjct: 676 VDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPP 735
Query: 453 -DLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI 511
A VT+++ D ND+ PEF Y +NE VGTSV++V+A D+D N I+Y I
Sbjct: 736 LSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQI 793
Query: 512 ASLNLL-PFVINQFTGVISTTEELDFESSPEIY-RFIVRASDWGSPYRHESEVNVTIRIG 569
N F I+ GV T L + E Y + ++ ASD V I I
Sbjct: 794 TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRAL----HDHCYVHINIT 849
Query: 570 NVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPD 629
+ N + P+F+ ++ D P+G I +SA D D E + + + L F ++ D
Sbjct: 850 DANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDAD 909
Query: 630 SGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVA 689
SG + L+ L + D ++ +++ + R+ +
Sbjct: 910 SGAITLQAPL--------------------DYEDQVTYTLAI----------TARDNGIP 939
Query: 690 QKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIK 749
QK A+ ++ N +N P F S + + V ED P ++L+I
Sbjct: 940 QK-ADTTYVEVMVN-------------DVNDNAPQFVASHYTGL-VSEDAPPFTSVLQIS 984
Query: 750 AYDADSGFNGKVLFTISDG-NTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGN 808
A D D+ NG+V +T +G + D F I+ +G ++ + +DRE +Y L D G
Sbjct: 985 ATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGV 1044
Query: 809 PQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTY 868
P + + + V+D NDN+PVF + + V + E+S +G+ + Q+ A D D G N + Y
Sbjct: 1045 PPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMY 1104
Query: 869 SVLTDT--QQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFL 926
++ + F ++ +G + LD E++ Y + ++A + L S T+ V L
Sbjct: 1105 QIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQA-----TSAPLVSRATVHVRL 1159
Query: 927 DDVNDCSPA-----FIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNG 981
D ND SP + ++Y + P G +I + +DPD+ + N+
Sbjct: 1160 VDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDVSDHLFYSFERGNELQ- 1217
Query: 982 RFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENL 1038
+++ SG +RLS++LD + ++ V D V+ V + VV + E L
Sbjct: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCV----LRVVIITEEL 1270
Score = 165 bits (417), Expect = 1e-39
Identities = 159/611 (26%), Positives = 279/611 (45%), Gaps = 51/611 (8%)
Query: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWD----IKYRIVSGDEEGFFKAEEVI 98
F+ Y A V E+ T V + +T D D + Y I+SG+ G F A + +
Sbjct: 545 FSEKRYVAQVREDVRPHTVV-----LRVTATDRDKDANGLVHYNIISGNSRGHF-AIDSL 598
Query: 99 IADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED-LEAWTKV-NIQVLDMNDLRP 156
+ + A L+ E + Y L ++ G L T + +IQV+D+ND P
Sbjct: 599 TGEIQVV---------APLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIP 649
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKV--DLFSVHPTSGVIS 214
+F T + V++ E+ PL SV + A DAD G N Y F ++ +G +S
Sbjct: 650 IFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVS 709
Query: 215 LSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVT-HVP 273
+SG L+ + Y + A D +G+ +S++A + V + +N++ P + H+
Sbjct: 710 VSGPLDRESVEHYFFGVEARD-----HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLR 764
Query: 274 FSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQID 333
+ + +VV+V +D AN I S I G+ ++F ++ +G + +D
Sbjct: 765 LNEDAAVGTSVVSVTAVDRDANSAI-SYQITGGNTRNRFAISTQG---GVGLVTLALPLD 820
Query: 334 WESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV 393
++ Y + L L A D+ C V+I +T F+ Y VS++E P G
Sbjct: 821 YKQERY-FKLVLTASDRALHDHC----YVHINITDANTHRPVFQSAHYSVSVNEDRPMGS 875
Query: 394 VVAIVKLSPEPIDVEYKLS--PGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKE 451
+ ++ S + + +++ ++ F+I+ SG I PL+ + Y L +T ++
Sbjct: 876 TIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARD 935
Query: 452 GDL--KAQVT---ISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
+ KA T + + D ND+ P+F Y V+E P TSVL +SA+D+D NG
Sbjct: 936 NGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGR 995
Query: 507 ITYSI--ASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNV 564
+ Y+ F I +G++ T LD E + +Y A D G P + V++
Sbjct: 996 VQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDRE-AVSVYELTAYAVDRGVP-PLRTPVSI 1053
Query: 565 TIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELG 622
+ + +VNDN+P+F + + + VG + ++A+D DE + Y+I+ GN
Sbjct: 1054 QVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPE 1113
Query: 623 FFYLNPDSGVL 633
F ++ SG L
Sbjct: 1114 LFQMDIFSGEL 1124
Score = 118 bits (296), Expect = 1e-25
Identities = 126/530 (23%), Positives = 236/530 (44%), Gaps = 56/530 (10%)
Query: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWD--IKYRIVSGDEEGFFKAEEVIIA 100
FT Y+ + E++A T V S +T +D + I Y+I G+ F
Sbjct: 756 FTMKEYHLRLNEDAAVGTSVVS-----VTAVDRDANSAISYQITGGNTRNRFA------- 803
Query: 101 DFCFLRIRTKGGNSAI-----LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLR 155
I T+GG + L+ + + + L++ S R L V+I + D N R
Sbjct: 804 ------ISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA--LHDHCYVHINITDANTHR 855
Query: 156 PLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISL 215
P+F YSV++ E P+ +++ ++A+D D+G N Y ++ + F + SG I+L
Sbjct: 856 PVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITL 915
Query: 216 SGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFS 275
L+Y+++ Y L I A D G+ + T + V + +N++AP +
Sbjct: 916 QAPLDYEDQVTYTLAITARDNGIP-----QKADTTYVEVMVNDVNDNAPQFVASHYTGLV 970
Query: 276 LEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQI 332
E P + V + D D ANG ++ + G+ D F + + ++ +++
Sbjct: 971 SEDAPPFTSVLQISATDRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGI----VRTVRRL 1025
Query: 333 DWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPG 392
D E+ Y LT A D+G P + + + D P+ F E ++V + E S G
Sbjct: 1026 DREAVSV-YELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPV-FPAEEFEVRVKENSIVG 1083
Query: 393 VVVA-IVKLSPEP---IDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT 448
VVA I + P+ + Y++ G F+++ SG + L+ ++ Y + V
Sbjct: 1084 SVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQ 1143
Query: 449 NKEGDLKAQVTISIE--DANDHTPEFQ--QPLYDAYV---NESVPVGTSVLTVSASDKDK 501
L ++ T+ + D ND++P Q L++ YV +++ P G + + A D D
Sbjct: 1144 ATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGI-IGRIPAYDPDV 1202
Query: 502 GENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
++ + ++ + L V+NQ +G + + +LD + P + +V +D
Sbjct: 1203 SDHLFYSFERGN-ELQLLVVNQTSGELRLSRKLD-NNRPLVASMLVTVTD 1250
Score = 80.9 bits (198), Expect = 3e-14
Identities = 88/344 (25%), Positives = 134/344 (38%), Gaps = 45/344 (13%)
Query: 3799 CVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLS---FAGNSYIKYRL-SENS 3854
C PC C S F C CP G G+ T F GN + + S+ +
Sbjct: 1726 CDSGPCKNSGFCSERWGS---FSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMA 1782
Query: 3855 KEEDFKLALRLRTLQSNGIIMYTRANP--CIILKIVDGKLWFQLDCGSGPGI-LGISGRA 3911
+ L L RT + G++M +A P ++ ++ G L + GSG L +
Sbjct: 1783 VSVPWYLGLAFRTRATQGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVT 1842
Query: 3912 VNDGSWHSVFLEL--------NRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVQ 3963
V+DG WH + LEL + +SLD S L+ T++ S + G V+
Sbjct: 1843 VSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFS--------LFQDTMAVGSELQ-GLKVK 1893
Query: 3964 ADNIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLGCVLYPD 4023
++ L + G GC+ V L + + + + GCV+ +
Sbjct: 1894 QLHVGGLPPGSAEEAPQGLVGCIQGVWLGST----PSGSPALLPPSHRVNAEPGCVV-TN 1948
Query: 4024 ACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPIGNT-- 4081
AC PC C L + CTC + G C + AC NPC+N GSC +
Sbjct: 1949 ACASGPCPPHADCRDLWQ-TFSCTCQPGYYGPGC---VDACLLNPCQNQGSCRHLPGAPH 2004
Query: 4082 -FICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNC 4124
+ C+C G G CE ++ ++C G G CNC
Sbjct: 2005 GYTCDCVGGYFGHHCEHRMD----QQCPRGWWGSPTCGP--CNC 2042
Score = 80.1 bits (196), Expect = 5e-14
Identities = 42/129 (32%), Positives = 55/129 (42%), Gaps = 24/129 (18%)
Query: 4023 DACKRSPCQHGGSCTGL---------------------PSGGYQCTCLSQFTGRNCESEI 4061
+ C R PC++ C + P G +C C FTG CE+E+
Sbjct: 1377 NVCLREPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETEL 1436
Query: 4062 TACFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEED--INECEREECENGGSCVNV-FG 4118
C+ NPCRNGG+C + C C+ TG CE D C C NGG+C + G
Sbjct: 1437 DLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNG 1496
Query: 4119 SFLCNCTPG 4127
F C C G
Sbjct: 1497 GFRCQCPAG 1505
Score = 69.3 bits (168), Expect = 8e-11
Identities = 36/84 (42%), Positives = 44/84 (52%), Gaps = 6/84 (7%)
Query: 4018 CVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCE--SEITACFPNPCRNGGSC 4075
C D C +PC++GG+C GGY C C +FTG +CE +E C P CRNGG+C
Sbjct: 1432 CETELDLCYSNPCRNGGAC-ARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTC 1490
Query: 4076 -DPIGNTFICNCKAG--LTGVTCE 4096
D F C C AG G CE
Sbjct: 1491 TDAPNGGFRCQCPAGGAFEGPRCE 1514
Score = 52.8 bits (125), Expect = 8e-06
Identities = 20/52 (38%), Positives = 27/52 (51%)
Query: 4084 CNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCGL 4135
C C G TG CE +++ C C NGG+C G + C C P + G+ C L
Sbjct: 1421 CRCPPGFTGDFCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCEL 1472
Score = 40.0 bits (92), Expect = 0.053
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 4095 CEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCGL 4135
C+ ++ C+ C+N G C +GSF C+C G+ G+ C L
Sbjct: 1719 CQAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKDCQL 1759
Score = 35.0 bits (79), Expect = 1.7
Identities = 17/61 (27%), Positives = 22/61 (36%), Gaps = 1/61 (1%)
Query: 3776 CPRFYRNVRCTCNGGLC-PGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSG 3834
C ++ CTC G PG D C+ PC C + + C C G G
Sbjct: 1961 CRDLWQTFSCTCQPGYYGPGCVDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCE 2020
Query: 3835 H 3835
H
Sbjct: 2021 H 2021
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 460 bits (1183), Expect = e-128
Identities = 403/1422 (28%), Positives = 632/1422 (44%), Gaps = 147/1422 (10%)
Query: 2754 GIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPV 2813
G F I+ TG + D LDRET +V A + T + + V D ND+ PV
Sbjct: 294 GYFRIDSATGAVSTDSVLDRETKETHVLRVKA-VDYSTPPRSATTYITVLVKDTNDHSPV 352
Query: 2814 FETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTG 2873
FE S Y + E + VG ++ +RA D D N + Y + + + F ++ ++G
Sbjct: 353 FEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGA-----WDVFQLNESSG 407
Query: 2874 WISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTALVSVRVTDINDNAPVFAQEVYRGN 2932
+ST LD E + V A+D G LS+TA V + V D NDN P F+++ Y
Sbjct: 408 VVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQ 467
Query: 2933 VKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDR 2992
V E V + DRD N + Y I GN G+F L + V PLD
Sbjct: 468 VPEDVGLNTAVLRVQATDRDQGQ-NAAIHYSILSGNVAGQFYLHSLSGILDVI--NPLDF 524
Query: 2993 EEQDIYFLNITATDG----LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKII 3048
E+ Y L+I A DG L + +V V V DVNDN P+ + A + E++P +
Sbjct: 525 EDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV 584
Query: 3049 LKVSAKDADIGSNGYIRYSLY-------GSGNS-----------EFFLDPESGELKTLAL 3090
+ + A DAD G N + Y L G G++ F + SG + A
Sbjct: 585 VHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE 644
Query: 3091 LDRERIPVYSLMAKATDGGGRFCQSN--IHLILEDVNDNPPVFSSDHYNTCVYENTATKA 3148
LDRE + YS +A D G S+ + + + DVNDN PVF+ Y + E+ A +
Sbjct: 645 LDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGS 704
Query: 3149 LLTRVQAVDPDIGINRKVVYSLAD-SAGGVFSIDSS--SGIIILEQPLDREQQSSYNISV 3205
+ +QA D D N + Y L + F++ S G+I L PLD +Q+ Y ++V
Sbjct: 705 SVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAV 762
Query: 3206 RATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDI 3265
A+D + S V I V D N + PVF+ Y V+V ED GT + + A +D
Sbjct: 763 TASDGTR----SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDT 818
Query: 3266 GTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVA 3325
G NA ITY+I+ Q F+I+P +G + LDYE + L + A+D G P S
Sbjct: 819 GENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTT 876
Query: 3326 TVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDR 3385
T+ I + D NDN P+F D Y I EDA S++ + A D DS PNG++ ++ GD
Sbjct: 877 TLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDD 936
Query: 3386 -DNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPA-MSSTATVNIDISDVNDNS 3443
D +F ++P G+++ +++LDRE V+ Y+L AVD G P +S++ + + I D+NDN+
Sbjct: 937 GDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNA 996
Query: 3444 PVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDP-HGI 3502
P+F ++EN PVG+ + ++ D D N + I+ G+ F LD +G
Sbjct: 997 PMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQ-IMYQIVEGDMRHFFQLDLLNGD 1055
Query: 3503 LRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEI----FI 3558
LR+ V EYVL VQA + VS + + +++++ + P +I ++
Sbjct: 1056 LRAMVELDFEVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYV 1112
Query: 3559 VTMEDDFPGGVIGKIHATDQDMYDVLTFA-LKSEQKSLFKVNSHDGKIIALGGLDSGK-- 3615
+ FP GVIG I A D D+ D L + ++ + L ++ G++ LD+ +
Sbjct: 1113 TNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPL 1172
Query: 3616 -YVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLR 3674
++ VSVSDG V + V + +ML N++T+R EN+S E F+ + F +
Sbjct: 1173 EALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVA 1232
Query: 3675 NAVLTQKQDSLRIISIQ--PVAGTNQLDMLFAVEMHS---SEFYKPAYLIQKLSNARRHL 3729
AVL+ +D + + ++Q +N L++ F+ + +F+ L +++ R L
Sbjct: 1233 -AVLSTTKDDVFVFNVQNDTDVSSNILNVTFSALLPGGVRGQFFPSEDLQEQIYLNRTLL 1291
Query: 3730 ENI--MRISAILEKNCSGLDCQE-QHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCT 3786
I R+ + C C+ C L DS A ST + F +RC
Sbjct: 1292 TTISTQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTT-VLFRPIHPINGLRCR 1350
Query: 3787 C----NGGLCPGSNDPCVEKPCPGDMQCVSYEASRR------------------------ 3818
C G C D C PC + +C S E
Sbjct: 1351 CPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANG 1410
Query: 3819 --------------PFLCQCPPGKLGE--CSGHTSLSFAGNSYIKYRLSENSKEEDFKLA 3862
F C CPPG+ C T+ SF S++ +R + F ++
Sbjct: 1411 VCKNGGTCVNLLIGGFHCVCPPGEYERPYCE-VTTRSFPPQSFVTFR--GLRQRFHFTIS 1467
Query: 3863 LRLRTLQSNGIIMY----TRANPCIILKIVDGKLWFQLDCGSGPGILGISGR---AVNDG 3915
L T + NG+++Y + I L+IVD ++ QL +G ++ + V+DG
Sbjct: 1468 LTFATQERNGLLLYNGRFNEKHDFIALEIVDEQV--QLTFSAGETTTTVAPKVPSGVSDG 1525
Query: 3916 SWHSVFLEL--NRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALV----------Q 3963
WHSV ++ N L L + A + T ++ FG + Q
Sbjct: 1526 RWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQ 1585
Query: 3964 ADNIRSLTDTRVTQVLSGFQGCLDSVILNNNE-------LPLQNKRSSFAEVVGLTELKL 4016
+ +SL D +L G + ++N + L + K A + +
Sbjct: 1586 TGSKKSL-DLTGPLLLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTRE 1644
Query: 4017 GCVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCE 4058
GC + C CQ+GG+C Y C C +F G+NCE
Sbjct: 1645 GCAARRNFCDGRRCQNGGTCVN-RWNMYLCECPLRFGGKNCE 1685
Score = 406 bits (1044), Expect = e-112
Identities = 302/984 (30%), Positives = 480/984 (48%), Gaps = 71/984 (7%)
Query: 940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYN----GRFEIDKASGAIRLS 995
+Y V + E+ P GT+I L H G +V Y + ++ G F ID A+GA+
Sbjct: 249 NYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTD 308
Query: 996 KELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKEN 1055
LD E ++ + L V+A D P S+ +++ V V D N+ H+P F V+EN
Sbjct: 309 SVLDRETKETHVLRVKAVDYSTPPR-SATTYITVLVKDTND--HSPVFEQSEYRERVREN 365
Query: 1056 SRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYW 1115
+G VL + A D DS + ++Y + G+ F +++ SGV++ +LDRE Y
Sbjct: 366 LEVGYEVLTIRASDRDSPINANLRYRVLGGAW-DVFQLNESSGVVSTRAVLDREEAAEYQ 424
Query: 1116 LTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAE 1173
L V A D+G PL +T VYIEVED NDN P SE Y V E+ + +V+++QA
Sbjct: 425 LLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQAT 484
Query: 1174 DPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSP 1233
D D N + Y I SGN F ++ +G++ + LD E ++ L + DGG P
Sbjct: 485 DRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN-PLDFEDVQKYSLSIKAQDGGRPP 543
Query: 1234 KQSTIWVV-VQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEIS 1292
++ VV VQVLD NDN+P F +Q + E G P+ A D D G NA +
Sbjct: 544 LINSSGVVSVQVLDVNDNEPIFVSSPFQATVLEN--VPLGYPVVHIQAVDADSGENARLH 601
Query: 1293 YSIVDG-----------------NDDGKFFIDPKTGMVSSRKQFTAGSYDILT--IKAVD 1333
Y +VD D F I +G ++ + + + ++AVD
Sbjct: 602 YRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVD 661
Query: 1334 NGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQP--ANT 1391
+G P SS+ + I + P+ F +P Y + E V V + + AN+
Sbjct: 662 HGSPPMSSSTSVSITVLDVNDNDPV---FTQPTYELRLNEDAAVGSSVLTLQARDRDANS 718
Query: 1392 PLWFDIVGGNFDSAF--DAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIK 1449
+ + + GGN + F +++G G I +A PLD +Q Y ++V +DGT V I
Sbjct: 719 VITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLIN 778
Query: 1450 VLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD--EKHKLSYTVHSSIDSISMR 1507
V D N + P F +Y V++SED T I + A D D E +++Y + +
Sbjct: 779 VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVP----- 833
Query: 1508 KFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFT 1567
+FRIDP +G +YT LD+E Q + L IM +D P + + + + + DAND++P F
Sbjct: 834 QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
Query: 1568 NPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGN-MFKIEPVLGIITIC 1626
Y+ S+FE A +++LQV+A D+D G N L+YT + G+ G+ F IEP G+I
Sbjct: 894 WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ 953
Query: 1627 KEPDMTTMGQFVLSIKVTDQGSP-PMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVD 1685
+ D + + L D+GSP P+SA+ +++++ +++ P F + + V EN
Sbjct: 954 RRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNP 1013
Query: 1686 IGTSVILISAIS-----QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLI 1740
+G+ V I A + ++Y++ +GD+ F ++ +G + LD+E Y L+
Sbjct: 1014 VGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLV 1073
Query: 1741 IQATNMAGMASNATVNIQIVDENDNAPV-----FLFSQYSGSLSEAAPINSIVRSLDNSP 1795
+QAT+ A + S ATV+I +VD+NDN PV LF+ Y + S + P I
Sbjct: 1074 VQATS-APLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIG------- 1125
Query: 1796 LVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRD 1855
I A D D + + L Y V+ + +D +TG ++ +LD+ V V D
Sbjct: 1126 -CIPAHDPDVSDS--LNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
Query: 1856 SGSPQLTAESPVEVNIEVTDVNDN 1879
G +TA + V I D+ N
Sbjct: 1183 -GIHSVTAFCTLRVTIITDDMLTN 1205
Score = 390 bits (1001), Expect = e-107
Identities = 302/976 (30%), Positives = 476/976 (48%), Gaps = 72/976 (7%)
Query: 1459 EFSQPNYDVTISEDVLPDTEILQIEA--TDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
+F PNY V + E+ T ILQ+ A T E+ ++SY + D S FRID +TG
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
+ T LD E ++ H+L + D P R + V V+D NDHSP F Y V
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQ 1636
E+ +G VL + A D+D NA L Y + G ++F++ G+++ D +
Sbjct: 364 ENLEVGYEVLTIRASDRDSPINANLRYRV-LGGAWDVFQLNESSGVVSTRAVLDREEAAE 422
Query: 1637 FVLSIKVTDQG--SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILIS 1694
+ L ++ DQG P+SATA V I V ++++P+F ++Y +V E+V + T+V+ +
Sbjct: 423 YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ 482
Query: 1695 AISQ-----STLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG- 1748
A + + + Y + G++ G F ++ SG++ LD+E Y L I+A +
Sbjct: 483 ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP 542
Query: 1749 --MASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSN 1806
+ S+ V++Q++D NDN P+F+ S + ++ E P+ V + I+A DADS
Sbjct: 543 PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV-------VHIQAVDADSG 595
Query: 1807 RNALLVYQIVESTAKKF------------------FTVDSSTGAIRTIANLDHETIAHFH 1848
NA L Y++V+ TA F F + +S+G I A LD E + H+
Sbjct: 596 ENARLHYRLVD-TASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
Query: 1849 FHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSAT 1908
F V D GSP ++ S V+I V DVNDN PVFTQ +E L VG VL + A
Sbjct: 655 FGVEAVDHGSPPMS--SSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQAR 712
Query: 1909 DPDSEVPPELTYSLMEGSL-DHFLIDSNSG----VLTIKNNNLSKDHYMLIVKVSDGKFY 1963
D D+ +TY L G+ + F + S G L + + + Y+L V SDG
Sbjct: 713 DRDAN--SVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRS 770
Query: 1964 STSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL--NEPLKYSILN 2021
T+ V I V +A F S Y+ S+SE+ T +A ++A N + Y I +
Sbjct: 771 HTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD 830
Query: 2022 PGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNS 2081
P +F+I SG + T + D E Q Y L + A + + + I D NDN+
Sbjct: 831 PVPQFRIDPDSGTMYTM-MELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
Query: 2082 PVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQ---DDYGHFEINPNSGN 2138
P F+ Y ++ DA P T I QV+A D+D GPNG + Y Q D G F I P SG
Sbjct: 890 PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG- 948
Query: 2139 VILKEAFNSDLSNIE-YGVTILAKDGGKPS-LSTSVELPITI--VNKAMPVFDKPFYTAS 2194
+++ D N+ Y + LA D G P+ LS SVE+ +TI +N P+F+K
Sbjct: 949 -VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELF 1007
Query: 2195 VNEDIRMNTPILSINATSPE---GQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVT 2251
V E+ + + + I A P+ I+Y I++GD F +D G L+ + LD+EV
Sbjct: 1008 VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVR 1067
Query: 2252 SAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPI---FDQPTYNTTLSEASLIGTPVLQ 2308
Y L ++A+ A +RA TV +L+ D NDNPP+ F N ++++ T V+
Sbjct: 1068 REYVLVVQATSAPLVSRA--TVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIG 1125
Query: 2309 VVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSID 2368
+ D + + ++Y VQ N +D ++G + +R LD+ ++V S+
Sbjct: 1126 CIPAH-DPDVSDSLNYTFVQG--NELRLLLLDPATGELQLSRDLDNNRPLEALMEV-SVS 1181
Query: 2369 SGFPSLSSEVLVHIYI 2384
G S+++ + + I
Sbjct: 1182 DGIHSVTAFCTLRVTI 1197
Score = 375 bits (963), Expect = e-103
Identities = 278/969 (28%), Positives = 469/969 (48%), Gaps = 44/969 (4%)
Query: 2496 FSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISY---AIINDFAKDRFLIDS-NGQ 2551
F Y + EN AGT ++ + A G ++SY + ++ ++ F IDS G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 2552 VITTERLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASV 2609
V T LDRE E V + V+A+D R+ + V+V D ND++P F EYR V
Sbjct: 305 VSTDSVLDRETK-ETHV-LRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
Query: 2610 RADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQL 2669
R ++ G+ V ++A D D N+ + Y + A D+ +++ +G + T+ ++
Sbjct: 363 RENLEVGYEVLTIRASDRDSPINANLRYRVLGGAW----DVFQLNESSGVVSTRAVLDRE 418
Query: 2670 KNTVLSFFVKAVDGGI---PVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
+ V+A D G P+ + VYI V P F++ Y + ED + +
Sbjct: 419 EAAEYQLLVEANDQGRNPGPLS-ATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTA 477
Query: 2727 VDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
V ++ + ++ N G F + +G + + LD E + + A
Sbjct: 478 VLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQ 537
Query: 2787 IPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGAN 2846
I + V ++VLD+NDN+P+F +S + ++E +P+G + ++A+D D G N
Sbjct: 538 DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597
Query: 2847 GQVTYSLHSDSQ------------PEKVME-AFNIDSNTGWISTLKDLDHETDPTFTFSV 2893
++ Y L + P + F I +++GWI+ +LD E ++F V
Sbjct: 598 ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGV 657
Query: 2894 VASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDT 2953
A D G +SS+ VS+ V D+NDN PVF Q Y + E G V L DRD
Sbjct: 658 EAVDHGSP-PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA 716
Query: 2954 SDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQA 3013
+ V ++Y +TGGN R RFAL + + + PLD +++ Y L +TA+DG A
Sbjct: 717 NSV---ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTA 773
Query: 3014 MVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGN 3073
V ++V+D N + PV YT + ED P I +SA D D G N I Y +
Sbjct: 774 HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPV- 832
Query: 3074 SEFFLDPESGELKTLALLDRERIPVYSLMAKATDGG--GRFCQSNIHLILEDVNDNPPVF 3131
+F +DP+SG + T+ LD E Y+L A D G + + + +++ D NDN P F
Sbjct: 833 PQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
Query: 3132 SSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSL--ADSAGGVFSIDSSSGIIIL 3189
D Y ++E+ + +V A D D G N +++Y+ D G F I+ +SG+I
Sbjct: 893 LWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRT 952
Query: 3190 EQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDT 3249
++ LDRE + YN+ A D+ LS+ + +T+LDINDN P+FE+ + + V E+
Sbjct: 953 QRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENN 1012
Query: 3250 SPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYL 3309
G+ V + A D G NA+I Y I G+ + F+++ G + LD+E+ + + L
Sbjct: 1013 PVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVL 1072
Query: 3310 VVEAKDGGTPALSAVATVNINLTDVNDNPPKFS--QDVYSAVISEDALVGDSVILLIAED 3367
VV+A + L + ATV+I L D NDNPP Q +++ ++ + + ++
Sbjct: 1073 VVQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPA 1129
Query: 3368 VDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMS 3427
D + ++++ V G+ +DP G +++ + LD R +L+ +V GI +++
Sbjct: 1130 HDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPL-EALMEVSVSDGIHSVT 1188
Query: 3428 STATVNIDI 3436
+ T+ + I
Sbjct: 1189 AFCTLRVTI 1197
Score = 372 bits (956), Expect = e-102
Identities = 291/973 (29%), Positives = 469/973 (48%), Gaps = 74/973 (7%)
Query: 1566 FTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEA---GNTGNMFKIEPVLGI 1622
F P Y+ ++FE+ G+ +LQ+ A +GE + Y +E + F+I+ G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 1623 ITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNE 1682
++ D T VL +K D +PP SAT + + V +++ P F +Y+ V E
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
Query: 1683 NVDIGTSVILISAISQ-----STLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSY 1737
N+++G V+ I A + + L Y V G + +F +N SGV++T+ LD E + Y
Sbjct: 365 NLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEY 423
Query: 1738 QLIIQAT----NMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDN 1793
QL+++A N +++ ATV I++ DENDN P F Y + E +N+ V
Sbjct: 424 QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV----- 478
Query: 1794 SPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHV 1853
L ++ATD D +NA + Y I+ F + S +G + I LD E + + +
Sbjct: 479 --LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKA 536
Query: 1854 RDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSE 1913
+D G P L S V V+++V DVNDN P+F + F+ +L +G V+ + A D DS
Sbjct: 537 QDGGRPPLINSSGV-VSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
Query: 1914 VPPELTYSLME--------GSLD----------HFLIDSNSGVLTI--KNNNLSKDHYML 1953
L Y L++ GS F I ++SG +T+ + + +HY
Sbjct: 596 ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSF 655
Query: 1954 IVKVSD---GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNR 2010
V+ D S++ V+I V + D+ FTQ Y ++E+ + V + A
Sbjct: 656 GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
Query: 2011 LNEPLKYSIL--NPGNKFKIKS-TSGVIQTTGVPFDREEQELYELVVEASRELDHLRVAR 2067
N + Y + N N+F + S G + T +P D ++++ Y L V AS D R
Sbjct: 716 ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTAS---DGTRSHT 772
Query: 2068 VVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDY 2127
V +N+ D N + PVF Y +V D GT I ++A D+D G N +TYV+QD
Sbjct: 773 AHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPV 832
Query: 2128 GHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLS--TSVELPITIVNKAMPV 2185
F I+P+SG + + + + + Y +TI+A+D G P S T++E+ I N P
Sbjct: 833 PQFRIDPDSGTMYTMMELDYE-NQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891
Query: 2186 FDKPFYTASVNEDIRMNTPILSINAT----SPEGQGIIYIIIDGDPFK-QFNIDFDTGVL 2240
F FY S+ ED +T IL ++AT P G+ ++Y GD F I+ +GV+
Sbjct: 892 FLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGR-LLYTFQGGDDGDGDFYIEPTSGVI 950
Query: 2241 KVVSPLDYEVTSAYKLTIRASD--ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSE 2298
+ LD E + Y L A D + T A V + + + D+NDN P+F++ + E
Sbjct: 951 RTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEE 1010
Query: 2299 ASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQ 2358
+ +G+ V ++ + D D N + YQIV+ + +F +D +G + LD E+ +
Sbjct: 1011 NNPVGSVVAKIRANDPDEGPNAQIMYQIVEG--DMRHFFQLDLLNGDLRAMVELDFEVRR 1068
Query: 2359 HCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFN--QLIYESYV---SELAPRGHFV 2413
L V++ + L S VHI + D NDNPPV Q+++ +YV S P G +
Sbjct: 1069 EYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VI 1124
Query: 2414 TCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD 2473
C+ A D D S D L Y+ + GN+ L+D +G + LS + VSVSD
Sbjct: 1125 GCIPAHDPDVS--DSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
Query: 2474 GLFTSTAQVHIRV 2486
G+ + TA +RV
Sbjct: 1183 GIHSVTAFCTLRV 1195
Score = 371 bits (953), Expect = e-102
Identities = 295/978 (30%), Positives = 460/978 (47%), Gaps = 102/978 (10%)
Query: 374 IRFEKEVYDVSISEFSPPGVVV----AIVKLSPEPIDVEYKLSPGEDAV---YFKINPRS 426
++F Y V++ E P G ++ A + E V Y + D YF+I+ +
Sbjct: 243 LKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSAT 302
Query: 427 GLIVTARPLNTVKKEVYKLEV-----TNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYV 481
G + T L+ KE + L V + +T+ ++D NDH+P F+Q Y V
Sbjct: 303 GAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
Query: 482 NESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPE 541
E++ VG VLT+ ASD+D N + Y + F +N+ +GV+ST LD E + E
Sbjct: 363 RENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAE 422
Query: 542 IYRFIVRASDWG-SPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAV 600
Y+ +V A+D G +P + V I + + NDN P F + + D + + V
Sbjct: 423 -YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRV 481
Query: 601 SAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDG 658
A D D+ + + Y I+SGN G FYL+ SG+L + L ++ ++L I A DG
Sbjct: 482 QATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQK--YSLSIKAQDG 539
Query: 659 ENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSI 718
P IN S G VS + +
Sbjct: 540 GR---PPLINSS---GVVS-----------------------------------VQVLDV 558
Query: 719 NRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISD----------- 767
N P F S P V E++P+G ++ I+A DADSG N ++ + + D
Sbjct: 559 NDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSA 617
Query: 768 ------GNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINV 821
D F I +G + V +DRE + Y + D G+P SS ++I V
Sbjct: 618 GPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITV 677
Query: 822 EDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAI 879
D NDN PVF Q +Y + + E + +G+ ++ ++ARD+D +N +TY + +FA+
Sbjct: 678 LDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRFAL 735
Query: 880 NSST--GIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI 937
+S G++ +A LD + + Y L + A D S + + + D N P F
Sbjct: 736 SSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRS-----HTAHVLINVTDANTHRPVFQ 790
Query: 938 PSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKE 997
S Y+V V ED PVGT IA L +D D G ++ Y ++ D +F ID SG + E
Sbjct: 791 SSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRIDPDSGTMYTMME 849
Query: 998 LDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSR 1057
LDYE Q Y LT+ A+D G P S + +E+ ++D N+N P F GS+ E++
Sbjct: 850 LDYENQVAYTLTIMAQDNGIP-QKSDTTTLEILILDANDN--APQFLWDFYQGSIFEDAP 906
Query: 1058 IGTSVLQVTARDEDSGRDGEIQYSIRDG-SGLGRFSIDDESGVITAADILDRETMGSYWL 1116
TS+LQV+A D DSG +G + Y+ + G G G F I+ SGVI LDRE + Y L
Sbjct: 907 PSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNL 966
Query: 1117 TVYATDRG-VVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDP 1175
A DRG PL +++E+ + + D+NDNAP+ + V EN+P V +I+A DP
Sbjct: 967 WALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDP 1026
Query: 1176 DSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ 1235
D N ++ Y+I G+ ++FF +++ G + +LD E + E+ L V T +P
Sbjct: 1027 DEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMV-ELDFEVRREYVLVVQATS---APLV 1082
Query: 1236 STIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNA--EISY 1293
S V + ++D+NDN P P+ +QI K P+ ++Y
Sbjct: 1083 SRATVHILLVDQNDNPPVLPD--FQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNY 1140
Query: 1294 SIVDGNDDGKFFIDPKTG 1311
+ V GN+ +DP TG
Sbjct: 1141 TFVQGNELRLLLLDPATG 1158
Score = 365 bits (938), Expect = e-100
Identities = 288/853 (33%), Positives = 419/853 (49%), Gaps = 63/853 (7%)
Query: 2814 FETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTG 2873
F +Y + E P GT + Q+ A G +V+Y + E+ F IDS TG
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFD-ERSRGYFRIDSATG 303
Query: 2874 WISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNV 2933
+ST LD ET T V A D S+T ++V V D ND++PVF Q YR V
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTP-PRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
Query: 2934 KESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE 2993
+E+ G V + DRD S +N + Y + GG L +S V + LDRE
Sbjct: 363 RENLEVGYEVLTIRASDRD-SPINANLRYRVLGG---AWDVFQLNESSGVVSTRAVLDRE 418
Query: 2994 EQDIYFLNITATD-----GLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKII 3048
E Y L + A D G A V + V D NDN P + Y +PED+ N +
Sbjct: 419 EAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
Query: 3049 LKVSAKDADIGSNGYIRYSLYGSGN--SEFFLDPESGELKTLALLDRERIPVYSLMAKAT 3106
L+V A D D G N I YS+ SGN +F+L SG L + LD E + YSL KA
Sbjct: 479 LRVQATDRDQGQNAAIHYSIL-SGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQ 537
Query: 3107 DGGGRFCQSNIHLI---LEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGIN 3163
DGG ++ ++ + DVNDN P+F S + V EN + +QAVD D G N
Sbjct: 538 DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597
Query: 3164 RKVVYSLADSA-----GGV-------------FSIDSSSGIIILEQPLDREQQSSYNISV 3205
++ Y L D+A GG F I +SSG I + LDRE+ Y+ V
Sbjct: 598 ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGV 657
Query: 3206 RATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDI 3265
A D +SS T+V+ITVLD+NDN PVF + Y + + ED + G+ VL + A +D
Sbjct: 658 EAVDHG-SPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD- 715
Query: 3266 GTNAEITYLIRSGNEQGKFKINPKTGG--ISVSEVLDYELCKRFYLVVEAKDGGTPALSA 3323
N+ ITY + GN + +F ++ + GG I+++ LDY+ +++ L V A DG S
Sbjct: 716 -ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSH 771
Query: 3324 VATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNG 3383
A V IN+TD N + P F Y+ +SED VG S+ L A D D+ N +I + I
Sbjct: 772 TAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ-- 829
Query: 3384 DRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNS 3443
D +F +DP G + +LD E Y+L + A D+GIP S T T+ I I D NDN+
Sbjct: 830 DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
Query: 3444 PVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNE-EEEFVLDP-HG 3501
P F Y I E+ P TSILQ+ TDRDS NG ++ G++ + +F ++P G
Sbjct: 890 PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNG-RLLYTFQGGDDGDGDFYIEPTSG 948
Query: 3502 ILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-IRVRVIEESTHKPTAIPLEIFIVT 3560
++R+ Y L A D G P +S + I+V +++ + + P E+ +
Sbjct: 949 VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFV 1008
Query: 3561 MEDDFPGGVIGKIHATDQD-------MYDVLTFALKSEQKSLFKVNSHDGKIIALGGLD- 3612
E++ G V+ KI A D D MY + ++ + + F+++ +G + A+ LD
Sbjct: 1009 EENNPVGSVVAKIRANDPDEGPNAQIMYQI----VEGDMRHFFQLDLLNGDLRAMVELDF 1064
Query: 3613 --SGKYVLNVSVS 3623
+YVL V +
Sbjct: 1065 EVRREYVLVVQAT 1077
Score = 359 bits (921), Expect = 4e-98
Identities = 285/978 (29%), Positives = 469/978 (47%), Gaps = 73/978 (7%)
Query: 733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS---DGNTDSCFNIDMETGQLKVLMPM 789
VA+ E+ P G IL++ A+ G +V + + D + F ID TG + +
Sbjct: 252 VALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVL 311
Query: 790 DREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTE 849
DRE + ++L + D P +S+ +T+ V+D ND+SPVF Q Y + E+ +G E
Sbjct: 312 DRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYE 371
Query: 850 IIQVEARDKDLGSNGEVTYSVLTDT-QQFAINSSTGIVYVADQLDRESKANYSLKIEARD 908
++ + A D+D N + Y VL F +N S+G+V LDRE A Y L +EA D
Sbjct: 372 VLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEAND 431
Query: 909 KAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ + L + T+ + ++D ND P F +Y V+V ED+ + T + ++ D D G
Sbjct: 432 QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
Query: 969 GQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFV 1027
+ YS+++ + G+F + SG + + LD+E Q Y+L+++A+D GRP ++S V
Sbjct: 492 AAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVV 551
Query: 1028 EVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD--- 1084
V+V+DVN+N P F +V EN +G V+ + A D DSG + + Y + D
Sbjct: 552 SVQVLDVNDN--EPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 1085 ----GSGLG----------RFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYS 1130
G G F I + SG IT LDRE + Y V A D G P+ S
Sbjct: 610 TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
Query: 1131 TIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSG 1190
+ V I V DVNDN P+ ++P Y + E++ SV+ +QA D D +N +TY++T G
Sbjct: 670 STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGG 727
Query: 1191 NPQNFFAINI-KTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDEND 1249
N +N FA++ + G + T + LD +Q+ ++ L VT +DG + T V++ V D N
Sbjct: 728 NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANT 784
Query: 1250 NKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPK 1309
++P F Y + + E DR G I A D D G NA I+Y I D +F IDP
Sbjct: 785 HRPVFQSSHYTVSVSE-DRPV-GTSIATLSANDEDTGENARITYVIQD--PVPQFRIDPD 840
Query: 1310 TGMVSSRKQFTAGSY--DILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFY 1367
+G + + + + LTI A DNG PQKS T L I + +P F FY
Sbjct: 841 SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAP---QFLWDFY 897
Query: 1368 NFTVME----SDRVTEIVGVVSVQPANTPLWFDIVGG-NFDSAFDAEKGVGTIVIAKPLD 1422
++ E S + ++ N L + GG + D F E G I + LD
Sbjct: 898 QGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD 957
Query: 1423 AEQRSIYNM-SVEVTDGTNV---AVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTE 1478
E ++YN+ ++ V G+ A ++ + +LD NDN P F + ++ + E+ +
Sbjct: 958 RENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSV 1017
Query: 1479 ILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMV 1538
+ +I A D DE + ++ ++ F++D G L LD E + +++L +
Sbjct: 1018 VAKIRANDPDEGPN-AQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA 1076
Query: 1539 RDQEFPYRRNLARVIVNVEDANDHSP-----------YFTNPLYEASVFESAALGSAVLQ 1587
R A V + + D ND+ P Y TN +++ F + +G
Sbjct: 1077 TSAPLVSR---ATVHILLVDQNDNPPVLPDFQILFNNYVTN---KSNSFPTGVIGC---- 1126
Query: 1588 VTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
+ A D D ++ L YT GN + ++P G + + ++ D + ++ + V+D G
Sbjct: 1127 IPAHDPDVSDS--LNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-G 1183
Query: 1648 SPPMSATAIVRISVTMSD 1665
++A +R+++ D
Sbjct: 1184 IHSVTAFCTLRVTIITDD 1201
Score = 354 bits (909), Expect = 1e-96
Identities = 286/985 (29%), Positives = 457/985 (46%), Gaps = 75/985 (7%)
Query: 2287 FDQPTYNTTLSEASLIGTPVLQV-VSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGL 2345
F P Y L E GT +LQ+ + E ++ +Y S YF IDS++G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 2346 ILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSE 2405
+ T +LD E + L+V+++D P S+ + + + D ND+ PVF Q Y V E
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
Query: 2406 LAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLY 2465
G+ V ++ASD DS L Y +L G F ++ SGV++ + Y
Sbjct: 365 NLEVGYEVLTIRASDRDSPINANLRYRVL-GGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
Query: 2466 SLNVSVSD-----GLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRA 2520
L V +D G ++TA V+I V N P FS+ YV +V E+V T V+ V+A
Sbjct: 424 QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQA 483
Query: 2521 TDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGD----VSIFVRALD 2576
TD D G I Y+I++ +F + S + LD NPL+ + S+ ++A D
Sbjct: 484 TDRDQGQNAAIHYSILSGNVAGQFYLHSLSGI-----LDVINPLDFEDVQKYSLSIKAQD 538
Query: 2577 GGGR---TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANS 2633
GG + V V V+D NDN P F++ ++A+V +V G+ V +QA+D D G N+
Sbjct: 539 GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
Query: 2634 RITYSLYSEASVSVAD--------------LLEIDPDNGWMVTKGNFNQLKNTVLSFFVK 2679
R+ Y L AS + +I +GW+ ++ + SF V+
Sbjct: 599 RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658
Query: 2680 AVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLR-------- 2731
AVD G P S V I VL P FTQ Y + ED A+GS+V TL+
Sbjct: 659 AVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANS 718
Query: 2732 ILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDK 2791
++ Q +T N + +GG G I L LD + + V A+
Sbjct: 719 VITYQLTGGNTRNRFALSSQRGG--------GLITLALPLDYKQEQQYVLAVTASDGTRS 770
Query: 2792 VDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTY 2851
T V I V D N ++PVF++S Y + E PVGT + + A D D G N ++TY
Sbjct: 771 ----HTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY 826
Query: 2852 SLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVS 2911
+ D P+ F ID ++G + T+ +LD+E +T +++A D G S T +
Sbjct: 827 VI-QDPVPQ-----FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP-QKSDTTTLE 879
Query: 2912 VRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRG 2971
+ + D NDNAP F + Y+G++ E PP + +S DRD S N ++ Y GG+ G
Sbjct: 880 ILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRD-SGPNGRLLYTFQGGDD-G 937
Query: 2972 RFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVT----QAMVEVSVSDVNDNSP 3027
+ + + +R LDRE +Y L A D T ++V++ D+NDN+P
Sbjct: 938 DGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAP 997
Query: 3028 VCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELK 3086
+ ++ + E+ P ++ K+ A D D G N I Y + FF LD +G+L+
Sbjct: 998 MFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLR 1057
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDH--YNTCV--YE 3142
+ LD E Y L+ +AT ++ +H++L D NDNPPV +N V
Sbjct: 1058 AMVELDFEVRREYVLVVQAT-SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKS 1116
Query: 3143 NTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYN 3202
N+ ++ + A DPD+ + + + + +D ++G + L + LD +
Sbjct: 1117 NSFPTGVIGCIPAHDPDVSDSLNYTFVQGNEL-RLLLLDPATGELQLSRDLDNNRPLEAL 1175
Query: 3203 ISVRATDQSPGQSLSSLTTVTITVL 3227
+ V +D S+++ T+ +T++
Sbjct: 1176 MEVSVSDGI--HSVTAFCTLRVTII 1198
Score = 335 bits (860), Expect = 5e-91
Identities = 279/935 (29%), Positives = 433/935 (46%), Gaps = 69/935 (7%)
Query: 2026 FKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFV 2085
F+I S +G + T V DRE +E + L V+A R A + V ++D ND+SPVF
Sbjct: 296 FRIDSATGAVSTDSV-LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
Query: 2086 GLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEA 2144
Y V+ + E G + + A D+D N + Y VL + F++N +SG V +
Sbjct: 355 QSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAV 414
Query: 2145 FNSDLSNIEYGVTILAKDGGKP----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIR 2200
+ + + EY + + A D G+ S + +V + + N P F + Y V ED+
Sbjct: 415 LDREEA-AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVG 473
Query: 2201 MNTPILSINATS-PEGQG--IIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLT 2257
+NT +L + AT +GQ I Y I+ G+ QF + +G+L V++PLD+E Y L+
Sbjct: 474 LNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
Query: 2258 IRASDA----LTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSID 2313
I+A D L + V+V +L DVNDN PIF + T+ E +G PV+ + ++D
Sbjct: 534 IKAQDGGRPPLINSSGVVSVQVL--DVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVD 591
Query: 2314 ADSENNKMVHYQIVQDTYN--------------STDY-FHIDSSSGLILTARMLDHELVQ 2358
ADS N +HY++V + D+ F I +SSG I LD E V+
Sbjct: 592 ADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVE 651
Query: 2359 HCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQA 2418
H + V ++D G P +SS V I + DVNDN PVF Q YE ++E A G V +QA
Sbjct: 652 HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA 711
Query: 2419 SDADSSDFDRLEYSILSGNDRTSFLMDSK--SGVITLSNHRKQRMEPLYSLNVSVSDGLF 2476
D D++ + Y + GN R F + S+ G+ITL+ + E Y L V+ SDG
Sbjct: 712 RDRDANSV--ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR 769
Query: 2477 TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAII 2536
+ TA V I V AN + P F S Y V E+ GT + + A D D G +I+Y I
Sbjct: 770 SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
Query: 2537 NDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDN 2596
+ + R DS G + T LD EN + ++I + ++ T+ ++++D NDN
Sbjct: 830 DPVPQFRIDPDS-GTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDN 888
Query: 2597 APQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPD 2656
APQF+ Y+ S+ D + QV A D D G N R+ Y+ + D I+P
Sbjct: 889 APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYT-FQGGDDGDGDFY-IEPT 946
Query: 2657 NGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSL-IPVYIHVLPPETFLPSFTQSQYSF 2715
+G + T+ ++ V + + AVD G P S + + + +L P F + +
Sbjct: 947 SGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL 1006
Query: 2716 TIAEDTAIGSTVDTLRIL-----PSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKR 2770
+ E+ +GS V +R P+ + + V G+ F ++ G ++
Sbjct: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRH-----FFQLDLLNGDLRAMVE 1061
Query: 2771 LDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFET-----SSYDTIIME 2825
LD E + V AT +V V I ++D NDN PV ++Y T
Sbjct: 1062 LDFEVRREYVLVVQAT----SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSN 1117
Query: 2826 GMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHET 2885
P G + + A D D V+ SL+ + +D TG + +DLD+
Sbjct: 1118 SFPTGV-IGCIPAHDPD------VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNR 1170
Query: 2886 DPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDN 2920
V SD S TA ++RVT I D+
Sbjct: 1171 PLEALMEVSVSD----GIHSVTAFCTLRVTIITDD 1201
Score = 333 bits (855), Expect = 2e-90
Identities = 294/1022 (28%), Positives = 449/1022 (43%), Gaps = 61/1022 (5%)
Query: 2599 QFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNG 2658
+F Y+ ++ + G L+ Q+ A +G R++Y + ID G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 2659 WMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIA 2718
+ T ++ VKAVD P + + + + V P F QS+Y +
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 2719 EDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGG---IFVIEQETGTIKLDKRLDRET 2775
E+ +G V T+R S +N GG +F + + +G + LDRE
Sbjct: 364 ENLEVGYEVLTIRASDRD----SPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREE 419
Query: 2776 SPAFHFKVAATIP-LDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLT 2834
+ + V A + + T V I+V D NDN P F +Y + E + + T +
Sbjct: 420 AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVL 479
Query: 2835 QVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVV 2894
+V+A D D G N + YS+ S + V F + S +G + + LD E ++ S+
Sbjct: 480 RVQATDRDQGQNAAIHYSILSGN----VAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
Query: 2895 ASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTS 2954
A D G ++S+ +VSV+V D+NDN P+F ++ V E+ P G V + D D+
Sbjct: 536 AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
Query: 2955 DVNRQVSYHIT--------GGN-------PRGRFALGLVQSEWKVYVKRPLDREEQDIYF 2999
+ N ++ Y + GG+ P F + S + V LDREE + Y
Sbjct: 596 E-NARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
Query: 3000 LNITATDG---LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDA 3056
+ A D + V ++V DVNDN PV Q Y L ED +L + A+D
Sbjct: 655 FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
Query: 3057 DIGSNGYIRYSLYGSGNSEFFL--DPESGELKTLAL-LDRERIPVYSLMAKATDGGGRFC 3113
D +N I Y L G F G L TLAL LD ++ Y L A+DG R
Sbjct: 715 D--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-RSH 771
Query: 3114 QSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADS 3173
+++ + + D N + PVF S HY V E+ + + A D D G N ++ Y + D
Sbjct: 772 TAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDP 831
Query: 3174 AGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNP 3233
F ID SG + LD E Q +Y +++ A D Q S TT+ I +LD NDN
Sbjct: 832 VPQ-FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK-SDTTTLEILILDANDNA 889
Query: 3234 PVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNE-QGKFKINPKTGG 3292
P F Y ++ ED P T +L V AT +D G N + Y + G++ G F I P +G
Sbjct: 890 PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
Query: 3293 ISVSEVLDYELCKRFYLVVEAKDGGTPA-LSAVATVNINLTDVNDNPPKFSQDVYSAVIS 3351
I LD E + L A D G+P LSA + + + D+NDN P F +D +
Sbjct: 950 IRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVE 1009
Query: 3352 EDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSG 3411
E+ VG V + A D D PN QI + IV GD + F +D + G ++ +LD E
Sbjct: 1010 ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE 1069
Query: 3412 YSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTP-----ANYTAVIQENKPVGTSIL 3466
Y L+VQA + + S ATV+I + D NDN PV NY + P G I
Sbjct: 1070 YVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGV-IG 1125
Query: 3467 QLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDP-HGILRSAVVFQHTESLEYVLCVQAKD 3525
+ D D +++ + GNE +LDP G L+ + + LE ++ V D
Sbjct: 1126 CIPAHDPDV---SDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
Query: 3526 SGKPQQVSHTYIRVRVIEES------THKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQD 3579
G + +RV +I + T + + E F+ + F GV + T D
Sbjct: 1183 -GIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDD 1241
Query: 3580 MY 3581
++
Sbjct: 1242 VF 1243
Score = 327 bits (839), Expect = 1e-88
Identities = 279/948 (29%), Positives = 437/948 (46%), Gaps = 67/948 (7%)
Query: 831 FIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSV--LTDTQQ---FAINSSTGI 885
F +Y V + E+ GT I+Q+ A G V+Y + L D + F I+S+TG
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 886 VYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKV 945
V LDRE+K + L+++A D + + + +T V + D ND SP F S Y +V
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYIT--VLVKDTNDHSPVFEQSEYRERV 362
Query: 946 LEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQF 1005
E+L VG + + D D + +RY ++ F+++++SG + LD E+
Sbjct: 363 RENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAE 422
Query: 1006 YNLTVRAKDKGR-PVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQ 1064
Y L V A D+GR P LS+ + V +EV D N+N P F + V V E+ + T+VL+
Sbjct: 423 YQLLVEANDQGRNPGPLSATATVYIEVEDENDNY--PQFSEQNYVVQVPEDVGLNTAVLR 480
Query: 1065 VTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRG 1124
V A D D G++ I YSI G+ G+F + SG++ + LD E + Y L++ A D G
Sbjct: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG 540
Query: 1125 VVPLY-STIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKL 1183
PL S+ V ++V DVNDN P+ + V+EN P V+ IQA D DS N +L
Sbjct: 541 RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARL 600
Query: 1184 TYRIT----------SGNPQN-------FFAINIKTGLITTTSRKLDREQQAEHFLEVTV 1226
YR+ S P+N F I+ +G IT + +LDRE+ + V
Sbjct: 601 HYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCA-ELDREEVEHYSFGVEA 659
Query: 1227 TDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEG 1286
D G P S+ V + VLD NDN P F + Y+++L E G + A DRD
Sbjct: 660 VDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNE--DAAVGSSVLTLQARDRD-- 715
Query: 1287 PNAEISYSIVDGNDDGKFFIDPKTG----MVSSRKQFTAGSYDILTIKAVDNGRPQKSST 1342
N+ I+Y + GN +F + + G ++ + +L + A D R S T
Sbjct: 716 ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR---SHT 772
Query: 1343 ARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNF 1402
A + I P+ F Y +V E V + +S +T I
Sbjct: 773 AHVLINVTDANTHRPV---FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
Query: 1403 DSA--FDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDG---TNVAVTQVFIKVLDNNDNG 1457
D F + GT+ LD E + Y +++ D T + I +LD NDN
Sbjct: 830 DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
Query: 1458 PEFSQPNYDVTISEDVLPDTEILQIEATDRDE--KHKLSYTVHSSIDSISMRKFRIDPST 1515
P+F Y +I ED P T ILQ+ ATDRD +L YT D F I+P++
Sbjct: 890 PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG--DFYIEPTS 947
Query: 1516 GVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLA-RVIVNVEDANDHSPYFTNPLYEAS 1574
GV+ T RLD E + L + D+ P + + + V + D ND++P F E
Sbjct: 948 GVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELF 1007
Query: 1575 VFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTM 1634
V E+ +GS V ++ A D D+G NA+++Y I G+ + F+++ + G + E D
Sbjct: 1008 VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVR 1067
Query: 1635 GQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILIS 1694
++VL ++ T S P+ + A V I + +++ P + D+Q N V ++
Sbjct: 1068 REYVLVVQAT---SAPLVSRATVHILLVDQNDNPP--VLPDFQILFNNYVTNKSNSFPTG 1122
Query: 1695 AIS---------QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYER 1733
I +L Y G+ + ++P +G + + LD R
Sbjct: 1123 VIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNR 1170
Score = 321 bits (822), Expect = 1e-86
Identities = 258/929 (27%), Positives = 426/929 (45%), Gaps = 108/929 (11%)
Query: 343 LTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLS- 401
L ++A D +P + + + T D P+ FE+ Y + E G V ++ S
Sbjct: 321 LRVKAVDYSTPPRSATTYITVLVKDTNDHSPV-FEQSEYRERVRENLEVGYEVLTIRASD 379
Query: 402 ---PEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKE-----GD 453
P ++ Y++ G V F++N SG++ T L+ + Y+L V + G
Sbjct: 380 RDSPINANLRYRVLGGAWDV-FQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGP 438
Query: 454 LKAQVT--ISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI 511
L A T I +ED ND+ P+F + Y V E V + T+VL V A+D+D+G+N I YSI
Sbjct: 439 LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI 498
Query: 512 ASLNLL-PFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGN 570
S N+ F ++ +G++ LDFE + Y ++A D G P S V++++ +
Sbjct: 499 LSGNVAGQFYLHSLSGILDVINPLDFEDVQK-YSLSIKAQDGGRPPLINSSGVVSVQVLD 557
Query: 571 VNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVK--YKIIS-------GNEL 621
VNDN P+F Q + + P+G + + A+D D E + Y+++ G
Sbjct: 558 VNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSA 617
Query: 622 GF----------FYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
G F ++ SG + + L +++ +F + ++ S++I+V
Sbjct: 618 GPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITV 677
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
L +N P F +
Sbjct: 678 L--------------------------------------------DVNDNDPVFTQP-TY 692
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQ--LKVLMPM 789
++ + ED VG+++L ++A D D+ N + + ++ GNT + F + + G + + +P+
Sbjct: 693 ELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPL 750
Query: 790 DREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTE 849
D + Y+L +T D +S + INV DAN + PVF Y+V++ E +GT
Sbjct: 751 DYKQEQQYVLAVTASD---GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTS 807
Query: 850 IIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDK 909
I + A D+D G N +TY + QF I+ +G +Y +LD E++ Y+L I A+D
Sbjct: 808 IATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDN 867
Query: 910 AESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGG 969
Q TL++ + D ND +P F+ Y + ED P T I + D D G G
Sbjct: 868 GI--PQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNG 925
Query: 970 QVRYSLV--NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFV 1027
++ Y+ +D +G F I+ SG IR + LD E YNL A D+G P LS+ +
Sbjct: 926 RLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEI 985
Query: 1028 EVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSG 1087
+V ++D+N+N P F + V+EN+ +G+ V ++ A D D G + +I Y I +G
Sbjct: 986 QVTILDINDN--APMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDM 1043
Query: 1088 LGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPL 1147
F +D +G + A LD E Y L V AT PL S V+I + D NDN P+
Sbjct: 1044 RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATS---APLVSRATVHILLVDQNDNPPV 1100
Query: 1148 TSEPIYYPVVMENSPKDVS-------VIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINI 1200
+ + ++ N + S + I A DPD S + L Y GN ++
Sbjct: 1101 LPD---FQILFNNYVTNKSNSFPTGVIGCIPAHDPDVS--DSLNYTFVQGNELRLLLLDP 1155
Query: 1201 KTGLITTTSRKLDREQQAEHFLEVTVTDG 1229
TG + SR LD + E +EV+V+DG
Sbjct: 1156 ATGEL-QLSRDLDNNRPLEALMEVSVSDG 1183
Score = 310 bits (794), Expect = 2e-83
Identities = 274/979 (27%), Positives = 449/979 (45%), Gaps = 97/979 (9%)
Query: 1151 PIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTY---RITSGNPQNFFAINIKTGLITT 1207
P Y + EN P ++Q+ A E+++Y + + +F I+ TG ++T
Sbjct: 248 PNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVST 307
Query: 1208 TSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERD 1267
S LDRE + H L V D P+ +T ++ V V D ND+ P F + Y+ ++ R+
Sbjct: 308 DS-VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV--RE 364
Query: 1268 RKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSR---KQFTAGSY 1324
+ G + A DRD NA + Y ++ G D F ++ +G+VS+R + A Y
Sbjct: 365 NLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEY 423
Query: 1325 DILTIKAVDNGR--PQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVME----SDRVT 1378
+L ++A D GR S+TA ++IE + P F E Y V E + V
Sbjct: 424 QLL-VEANDQGRNPGPLSATATVYIEVEDENDNYP---QFSEQNYVVQVPEDVGLNTAVL 479
Query: 1379 EIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDG 1438
+ Q N + + I+ GN F G + + PLD E Y++S++ DG
Sbjct: 480 RVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDG 539
Query: 1439 TNVAVTQ----VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD--EKHK 1492
+ V ++VLD NDN P F + T+ E+V ++ I+A D D E +
Sbjct: 540 GRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENAR 599
Query: 1493 LSYTVHSSIDSISM-----------------RKFRIDPSTGVLYTAERLDHEAQDKHILN 1535
L Y + +D+ S F+I S+G + LD E + +
Sbjct: 600 LHYRL---VDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFG 656
Query: 1536 IMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDK 1595
+ D P + V + V D ND+ P FT P YE + E AA+GS+VL + A D+D
Sbjct: 657 VEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD- 715
Query: 1596 GENAELIYTIEAGNTGNMFKIEPVL--GIITICKEPDMTTMGQFVLSIKVTDQGSPPMSA 1653
N+ + Y + GNT N F + G+IT+ D Q+VL++ +D S
Sbjct: 716 -ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD---GTRSH 771
Query: 1654 TAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST-----LIYEVKDG 1708
TA V I+VT ++ P F Y V+E+ +GTS+ +SA + T + Y ++D
Sbjct: 772 TAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDP 831
Query: 1709 DINGIFTINPYSGVITTQKALDYERTSSYQLIIQA--TNMAGMASNATVNIQIVDENDNA 1766
F I+P SG + T LDYE +Y L I A + + T+ I I+D NDNA
Sbjct: 832 VPQ--FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
Query: 1767 PVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV-ESTAKKFFT 1825
P FL+ Y GS+ E AP ++ S L + ATD DS N L+Y F
Sbjct: 890 PQFLWDFYQGSIFEDAPPST-------SILQVSATDRDSGPNGRLLYTFQGGDDGDGDFY 942
Query: 1826 VDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQ 1885
++ ++G IRT LD E +A ++ D GSP + S VE+ + + D+NDN P+F +
Sbjct: 943 IEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSAS-VEIQVTILDINDNAPMFEK 1001
Query: 1886 AVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFL-IDSNSGVL--TIK 1942
E + VG V K+ A DPD ++ Y ++EG + HF +D +G L ++
Sbjct: 1002 DELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVE 1061
Query: 1943 NNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSG--LHFTQSFYSTSISENNTNITK 2000
+ + Y+L+V+ + S + V I++ + D+ L Q ++ ++ N +N
Sbjct: 1062 LDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVT-NKSNSFP 1120
Query: 2001 VAIVNAVGNR---LNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEAS 2057
++ + +++ L Y+ + GN+ ++ + D EL + S
Sbjct: 1121 TGVIGCIPAHDPDVSDSLNYTFVQ-GNELRL-----------LLLDPATGEL-----QLS 1163
Query: 2058 RELDHLRVARVVVRVNIED 2076
R+LD+ R ++ V++ D
Sbjct: 1164 RDLDNNRPLEALMEVSVSD 1182
Score = 305 bits (780), Expect = 9e-82
Identities = 283/979 (28%), Positives = 444/979 (45%), Gaps = 75/979 (7%)
Query: 1670 KFIHKDYQAEVNENVDIGTSVILISAI-----SQSTLIYEVK---DGDINGIFTINPYSG 1721
KF +YQ + EN GT ++ + A + + Y ++ D G F I+ +G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 1722 VITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIV--DENDNAPVFLFSQYSGSLS 1779
++T LD E ++ L ++A + + +AT I ++ D ND++PVF S+Y +
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 1780 EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANL 1839
E + V L IRA+D DS NA L Y+++ A F ++ S+G + T A L
Sbjct: 364 ENLEVGYEV-------LTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTRAVL 415
Query: 1840 DHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVG 1899
D E A + V D G + V IEV D NDN P F++ + ++ +P VG
Sbjct: 416 DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNY--VVQVPEDVG 473
Query: 1900 VE--VLKVSATDPDSEVPPELTYSLMEGSL-DHFLIDSNSGVLTIKNNNLSKD--HYMLI 1954
+ VL+V ATD D + YS++ G++ F + S SG+L + N +D Y L
Sbjct: 474 LNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
Query: 1955 VKVSDG----KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAV--G 2008
+K DG S+ +V++ V + D+ F S + ++ EN V + AV
Sbjct: 534 IKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDAD 593
Query: 2009 NRLNEPLKYSILN-------------------PGNKFKIKSTSGVIQTTGVPFDREEQEL 2049
+ N L Y +++ P F+I ++SG I T DREE E
Sbjct: 594 SGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI-TVCAELDREEVEH 652
Query: 2050 YELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAI 2109
Y VEA + V + + D+NDN PVF Y + DA G+ + + A
Sbjct: 653 YSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQAR 712
Query: 2110 DKDKGPNGEVTYVLQ--DDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPS 2167
D+D N +TY L + F ++ G ++ A D + V + G S
Sbjct: 713 DRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRS 770
Query: 2168 LSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT---SPEGQGIIYIIID 2224
+ V + +T N PVF YT SV+ED + T I +++A + E I Y+I
Sbjct: 771 HTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI-- 828
Query: 2225 GDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAE-VTVDLLVNDVNDN 2283
DP QF ID D+G + + LDYE AY LTI A D +++ T+++L+ D NDN
Sbjct: 829 QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDN 888
Query: 2284 PPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSS 2343
P F Y ++ E + T +LQV + D DS N + Y Q + F+I+ +S
Sbjct: 889 APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTF-QGGDDGDGDFYIEPTS 947
Query: 2344 GLILTARMLDHELVQHCTLKVRSIDSGFPS-LSSEVLVHIYISDVNDNPPVFNQLIYESY 2402
G+I T R LD E V L ++D G P+ LS+ V + + I D+NDN P+F + E +
Sbjct: 948 GVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELF 1007
Query: 2403 VSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRME 2462
V E P G V ++A+D D ++ Y I+ G+ R F +D +G + +
Sbjct: 1008 VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVR 1067
Query: 2463 PLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQ-----STYVAEVRENVAAGTKVIH 2517
Y L V + S A VHI ++ N P + YV + G VI
Sbjct: 1068 REYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG--VIG 1125
Query: 2518 VRATDGDPGTYGQISYAIINDFAKDRFLID-SNGQVITTERLDRENPLEGDVSIFVRALD 2576
DP ++Y + L+D + G++ + LD PLE + + V D
Sbjct: 1126 CIPAH-DPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVS--D 1182
Query: 2577 G-GGRTTFCTVRVIVVDEN 2594
G T FCT+RV ++ ++
Sbjct: 1183 GIHSVTAFCTLRVTIITDD 1201
Score = 298 bits (764), Expect = 6e-80
Identities = 292/1088 (26%), Positives = 473/1088 (43%), Gaps = 141/1088 (12%)
Query: 158 FSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD-----LFSVHPTSGV 212
F Y V + E+ P T + Q+ A G YY + D F + +G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 213 ISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHV 272
+S L+ + K + L + AVD Y S+T + V ++ N+H+P +
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVD-----YSTPPRSATTYITVLVKDTNDHSPVFEQSEYR 359
Query: 273 PFSLEK-EPTYAVVTV--DDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKER 329
E E Y V+T+ D D N + V G D F L + ++ + +R
Sbjct: 360 ERVRENLEVGYEVLTIRASDRDSPINANLRYR--VLGGAWDVFQLNESSGVVSTRAVLDR 417
Query: 330 KQIDWESFPYGYNLTLQAKDKG-SPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEF 388
++ Y L ++A D+G +P SA VYI + +F ++ Y V + E
Sbjct: 418 EEAA------EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPE- 470
Query: 389 SPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEV 442
G+ A++++ D + Y + G A F ++ SG++ PL+ +
Sbjct: 471 -DVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQK 529
Query: 443 YKLEVTNKEG------DLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSA 496
Y L + ++G + V++ + D ND+ P F + A V E+VP+G V+ + A
Sbjct: 530 YSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQA 589
Query: 497 SDKDKGENGYITYSI---ASLNL---------------LPFVINQFTGVISTTEELDFES 538
D D GEN + Y + AS L PF I+ +G I+ ELD E
Sbjct: 590 VDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREE 649
Query: 539 SPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHIT 598
E Y F V A D GSP S +V+I + +VNDN P+F + + ++ D VG +
Sbjct: 650 V-EHYSFGVEAVDHGSPPM-SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL 707
Query: 599 AVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDG 658
+ A D D ++ Y++ GN F L+ G + +L + + L +TA+DG
Sbjct: 708 TLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG 767
Query: 659 ENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSI 718
A+ +N+ D
Sbjct: 768 TR--------------------------------------SHTAHVLINVTDA------- 782
Query: 719 NRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDM 778
N P F S + V+V ED PVG +I + A D D+G N ++ + I D F ID
Sbjct: 783 NTHRPVFQSSHYT-VSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDP 839
Query: 779 ETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSV 838
++G + +M +D E+ Y L I D G PQKS L I + DANDN+P F+ D Y
Sbjct: 840 DSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQG 899
Query: 839 NILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ---QFAINSSTGIVYVADQLDRE 895
+I E + T I+QV A D+D G NG + Y+ F I ++G++ +LDRE
Sbjct: 900 SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRE 959
Query: 896 SKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI 955
+ A Y+L A D+ S L + V ++V + D+ND +P F + V E+ PVG+V+
Sbjct: 960 NVAVYNLWALAVDRG-SPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVV 1018
Query: 956 AWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD 1014
A + +DPD G Q+ Y +V D F++D +G +R ELD+E ++ Y L V+A
Sbjct: 1019 AKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA-- 1076
Query: 1015 KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGS---VKENSRIGTSVLQ-VTARDE 1070
S VS V ++ V++N + P PDF ++ + +++ T V+ + A D
Sbjct: 1077 ----TSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDP 1132
Query: 1071 DSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGV--VPL 1128
D + Y+ G+ L +D +G + + LD + V +D G+ V
Sbjct: 1133 DV--SDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTA 1189
Query: 1129 YSTIEVYIEVEDVNDNA------PLTSEPIYYPV----------VMENSPKDVSVIQIQA 1172
+ T+ V I +D+ N+ ++ E P+ V+ + DV V +Q
Sbjct: 1190 FCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQ- 1248
Query: 1173 EDPDSSSN 1180
D D SSN
Sbjct: 1249 NDTDVSSN 1256
Score = 281 bits (720), Expect = 8e-75
Identities = 200/626 (31%), Positives = 310/626 (49%), Gaps = 44/626 (7%)
Query: 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYG----SGNSEFFLDPESGELKTLA 3089
Y L E+ P+ +IL++ A G + Y + G F +D +G + T +
Sbjct: 250 YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDS 309
Query: 3090 LLDRERIPVYSLMAKATDGGG--RFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATK 3147
+LDRE + L KA D R + I ++++D ND+ PVF Y V EN
Sbjct: 310 VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVG 369
Query: 3148 ALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRA 3207
+ ++A D D IN + Y + A VF ++ SSG++ LDRE+ + Y + V A
Sbjct: 370 YEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEA 429
Query: 3208 TDQ--SPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDI 3265
DQ +PG LS+ TV I V D NDN P F ++Y+V VPED T VL V AT +D
Sbjct: 430 NDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
Query: 3266 GTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPAL-SAV 3324
G NA I Y I SGN G+F ++ +G + V LD+E +++ L ++A+DGG P L ++
Sbjct: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
Query: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVN-- 3382
V++ + DVNDN P F + A + E+ +G V+ + A D DS N ++H+ +V+
Sbjct: 549 GVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTA 608
Query: 3383 ---------GDR------DNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMS 3427
G + D F + G + V +LDRE V YS V+AVD G P MS
Sbjct: 609 STFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMS 668
Query: 3428 STATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSIL 3487
S+ +V+I + DVNDN PVFT Y + E+ VG+S+L L DRD+ ++ +
Sbjct: 669 SSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA---NSVITYQLT 725
Query: 3488 SGNEEEEFVLDPH---GILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHT-YIRVRVIE 3543
GN F L G++ A+ + + +YVL V A D + SHT ++ + V +
Sbjct: 726 GGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR----SHTAHVLINVTD 781
Query: 3544 ESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYD--VLTFALKSEQKSLFKVNSH 3601
+TH+P + ED G I + A D+D + +T+ ++ + F+++
Sbjct: 782 ANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ-DPVPQFRIDPD 840
Query: 3602 DGKIIALGGLD---SGKYVLNVSVSD 3624
G + + LD Y L + D
Sbjct: 841 SGTMYTMMELDYENQVAYTLTIMAQD 866
Score = 236 bits (602), Expect = 4e-61
Identities = 263/1024 (25%), Positives = 434/1024 (42%), Gaps = 146/1024 (14%)
Query: 31 QGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEG 90
+G G G L F + Y ++EN A T + L Y I G+EE
Sbjct: 235 RGTSGRGSLKFPMPN--YQVALFENEPAGTLI------------LQLHAHYTI-EGEEER 279
Query: 91 FFKAEEVIIADFC--FLRIRTKGG---NSAILNREIQDNYLLIVKG-SVRGEDLEAWTKV 144
E + + + RI + G ++L+RE ++ ++L VK A T +
Sbjct: 280 VSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYI 339
Query: 145 NIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEF-YYYFKNKVDL 203
+ V D ND P+F + Y + E+ + V + A+D D N Y D+
Sbjct: 340 TVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV 399
Query: 204 FSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNG-VSSTAKLYVHIERINEH 262
F ++ +SGV+S L+ +E Y L + A D+G N G +S+TA +Y+ +E N++
Sbjct: 400 FQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGR----NPGPLSATATVYIEVEDENDN 455
Query: 263 APTI---HVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGK 319
P + V VP + V D D G N I SI++G+ QF+L
Sbjct: 456 YPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIH-YSILSGNVAGQFYLHSLSG 514
Query: 320 WLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIG-NPTRDTVPIRFEK 378
L+ +D+E Y+L+++A+D G P ++ V + D PI F
Sbjct: 515 ILDVI-----NPLDFEDV-QKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI-FVS 567
Query: 379 EVYDVSISEFSPPGVVVAIVKL----SPEPIDVEYKL------------------SPGED 416
+ ++ E P G V ++ S E + Y+L +P D
Sbjct: 568 SPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPD 627
Query: 417 AVYFKINPRSGLIVTARPLNTVKKEVYKLEVT-----NKEGDLKAQVTISIEDANDHTPE 471
F+I+ SG I L+ + E Y V + V+I++ D ND+ P
Sbjct: 628 -FPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPV 686
Query: 472 FQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIA---SLNLLPFVINQFTGVI 528
F QP Y+ +NE VG+SVLT+ A D+D N ITY + + N + G+I
Sbjct: 687 FTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLI 744
Query: 529 STTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVIS 588
+ LD++ + Y V ASD + +NVT + N + P+F+ +S
Sbjct: 745 TLALPLDYKQEQQ-YVLAVTASDGTRSHTAHVLINVT----DANTHRPVFQSSHYTVSVS 799
Query: 589 YDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGN 648
D PVG I +SA D D E + + + + F ++PDSG + L
Sbjct: 800 EDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYE--NQVA 857
Query: 649 FALRITATDG--ENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKL 706
+ L I A D +D ++ I +L ++ F
Sbjct: 858 YTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF------------------------- 892
Query: 707 NLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS 766
DFY QG F ED P +IL++ A D DSG NG++L+T
Sbjct: 893 -----LWDFY----QGSIF-----------EDAPPSTSILQVSATDRDSGPNGRLLYTFQ 932
Query: 767 DGNT-DSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRL-LTINVEDA 824
G+ D F I+ +G ++ +DRE+ +Y L D G+P S + + + + D
Sbjct: 933 GGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDI 992
Query: 825 NDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINSS 882
NDN+P+F +D + + E++ +G+ + ++ A D D G N ++ Y ++ + F ++
Sbjct: 993 NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLL 1052
Query: 883 TGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIP---- 938
G + +LD E + Y L ++A + L S T+ + L D ND +P +P
Sbjct: 1053 NGDLRAMVELDFEVRREYVLVVQA-----TSAPLVSRATVHILLVDQND-NPPVLPDFQI 1106
Query: 939 --SSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR-FEIDKASGAIRLS 995
++Y P G VI + HDPD + + Y+ V R +D A+G ++LS
Sbjct: 1107 LFNNYVTNKSNSFPTG-VIGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLS 1163
Query: 996 KELD 999
++LD
Sbjct: 1164 RDLD 1167
Score = 234 bits (597), Expect = 1e-60
Identities = 239/934 (25%), Positives = 406/934 (43%), Gaps = 133/934 (14%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDL---------SWDIKYRIVSGDEEGFFKAEEVII 99
++ V+E S R V +G ++ + + +++YR++ G + F E +
Sbjct: 349 HSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGV 408
Query: 100 ADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED---LEAWTKVNIQVLDMNDLRP 156
A+L+RE Y L+V+ + +G + L A V I+V D ND P
Sbjct: 409 VS-----------TRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYP 457
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF--KNKVDLFSVHPTSGVIS 214
FS Y V + E L T+V +V ATD D G N +Y N F +H SG++
Sbjct: 458 QFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILD 517
Query: 215 LSGRLNYDEKNRYDLEILAVDRGM-KLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+ L++++ +Y L I A D G L ++GV S V + +N++ P + P
Sbjct: 518 VINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVS-----VQVLDVNDNEP---IFVSSP 569
Query: 274 FS---LEKEPT-YAVVTVD--DLDDGANGE-----IESVSIVAG-----------DPLDQ 311
F LE P Y VV + D D G N +++ S G P
Sbjct: 570 FQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFP 629
Query: 312 FFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDT 371
F + W+ +R++++ Y+ ++A D GSP S+ D
Sbjct: 630 FQIHNSSGWITVCAELDREEVE------HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDN 683
Query: 372 VPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID--VEYKLSPGEDAVYFKINPR--SG 427
P+ F + Y++ ++E + G V ++ + + Y+L+ G F ++ + G
Sbjct: 684 DPV-FTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGG 742
Query: 428 LIVTARPLNTVKKEVYKLEVTNKEGDLK--AQVTISIEDANDHTPEFQQPLYDAYVNESV 485
LI A PL+ +++ Y L VT +G A V I++ DAN H P FQ Y V+E
Sbjct: 743 LITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDR 802
Query: 486 PVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRF 545
PVGTS+ T+SA+D+D GEN ITY I + F I+ +G + T ELD+E+ Y
Sbjct: 803 PVGTSIATLSANDEDTGENARITYVIQD-PVPQFRIDPDSGTMYTMMELDYENQ-VAYTL 860
Query: 546 IVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDI 605
+ A D G P + ++ + I I + NDN+P F QG I D P I VSA D
Sbjct: 861 TIMAQDNGIPQKSDT-TTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDR 919
Query: 606 DE--LELVKYKIISGNE-LGFFYLNPDSGVLQLKKSLTNSGIKNGN-FALRITATDGENL 661
D + Y G++ G FY+ P SGV++ ++ L + N +AL + L
Sbjct: 920 DSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPL 979
Query: 662 ADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQ 721
+ + I +++L IN
Sbjct: 980 SASVEIQVTIL--------------------------------------------DINDN 995
Query: 722 GPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETG 781
P F+K ++ V+E+ PVG+ + KI+A D D G N ++++ I +G+ F +D+ G
Sbjct: 996 APMFEKD-ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNG 1054
Query: 782 QLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPV-----FIQDSY 836
L+ ++ +D E Y+L + +++ +L + D NDN PV + ++Y
Sbjct: 1055 DLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLV---DQNDNPPVLPDFQILFNNY 1111
Query: 837 SVNILESSGIGTEIIQ-VEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRE 895
N +S+ T +I + A D D+ + T+ + + ++ +TG + ++ LD
Sbjct: 1112 VTN--KSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNN 1169
Query: 896 SKANYSLKIEARDKAESGQQLFSVVTLKVFLDDV 929
+++ D S F + + + DD+
Sbjct: 1170 RPLEALMEVSVSDGIHS-VTAFCTLRVTIITDDM 1202
Score = 161 bits (408), Expect = 1e-38
Identities = 163/602 (27%), Positives = 276/602 (45%), Gaps = 52/602 (8%)
Query: 115 AILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL 173
A L+RE ++Y V+ G + + T V+I VLD+ND P+F+ TY + + E +
Sbjct: 643 AELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAV 702
Query: 174 RTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYDEKNRYDLEI 231
+SV + A D D S + N + F++ G+I+L+ L+Y ++ +Y L +
Sbjct: 703 GSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAV 762
Query: 232 LAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLD 291
A D G + S TA + +++ N H P + E P + +
Sbjct: 763 TASD-GTR-------SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSAN 814
Query: 292 DGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKG 351
D GE ++ V DP+ QF + + + Y + E +D+E+ Y LT+ A+D G
Sbjct: 815 DEDTGENARITYVIQDPVPQFRIDPDSGTM--YTMME---LDYEN-QVAYTLTIMAQDNG 868
Query: 352 SPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID----- 406
PQK + D P +F + Y SI E +PP +I+++S D
Sbjct: 869 IPQKSDTTTLEILILDANDNAP-QFLWDFYQGSIFEDAPPST--SILQVSATDRDSGPNG 925
Query: 407 -VEYKLSPGEDAVY-FKINPRSGLIVTARPLNTVKKEVYKL--------EVTNKEGDLKA 456
+ Y G+D F I P SG+I T R L+ VY L T ++
Sbjct: 926 RLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEI 985
Query: 457 QVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNL 516
QVTI D ND+ P F++ + +V E+ PVG+ V + A+D D+G N I Y I ++
Sbjct: 986 QVTIL--DINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDM 1043
Query: 517 LPFV-INQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNS 575
F ++ G + ELDFE E Y +V+A+ +P S V I + + NDN
Sbjct: 1044 RHFFQLDLLNGDLRAMVELDFEVRRE-YVLVVQATS--APL--VSRATVHILLVDQNDNP 1098
Query: 576 PLFE--KVACQGVI---SYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDS 630
P+ ++ + S FP G I + A D D + + Y + GNEL L+P +
Sbjct: 1099 PVLPDFQILFNNYVTNKSNSFPTGV-IGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPAT 1157
Query: 631 GVLQLKKSLTNSGIKNGNFALRITATDG-ENLADPMSINISVLHGKVSSKSFSCRETRVA 689
G LQL + L N+ + + ++ +DG ++ ++ ++++ + + S + R ++
Sbjct: 1158 GELQLSRDLDNN--RPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMS 1215
Query: 690 QK 691
Q+
Sbjct: 1216 QE 1217
Score = 80.5 bits (197), Expect = 4e-14
Identities = 45/134 (33%), Positives = 56/134 (41%), Gaps = 25/134 (18%)
Query: 4025 CKRSPCQHGGSCTGL---------------------PSGGYQCTCLSQFTGRNCESEITA 4063
C R PC++ C + P G +C C FTG CE+EI
Sbjct: 1307 CLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDL 1366
Query: 4064 CFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEEDI--NECEREECENGGSCVN-VFGSF 4120
C+ +PC G C + C C TG CE D C C+NGG+CVN + G F
Sbjct: 1367 CYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGF 1426
Query: 4121 LCNCTPG-YVGQYC 4133
C C PG Y YC
Sbjct: 1427 HCVCPPGEYERPYC 1440
Score = 76.6 bits (187), Expect = 5e-13
Identities = 81/328 (24%), Positives = 136/328 (41%), Gaps = 42/328 (12%)
Query: 3792 CPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCP---PGKLGECSGHTSLSFAGNSYIKY 3848
C + C + C CV+ +LC+CP GK E + F+G S + +
Sbjct: 1646 CAARRNFCDGRRCQNGGTCVN---RWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSW 1702
Query: 3849 RLSENSKEEDFKLALRLRTLQSNGIIMY-TRANPCII-LKIVDGKLWFQLDCG-SGPGIL 3905
+ L L RT + + ++M T P L+I++ L F++ G S +
Sbjct: 1703 SDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESV 1762
Query: 3906 GISGRAVNDGSWHSVFLELN--------RNFTSLSLDDSYVERRRAPLYFQTLSTESSIY 3957
+SG V DG WH + +EL ++ +++LD +++ +A + +
Sbjct: 1763 MLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYG-MDQNKADI--------GGML 1813
Query: 3958 FGALVQADNIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLG 4017
G V++ + ++ +V+ V GF+GC+ V + + + A V +K G
Sbjct: 1814 PGLTVRSVVVGGASEDKVS-VRRGFRGCMQGVRMGGTPTNVATLNMNNALKV---RVKDG 1869
Query: 4018 CVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSC-- 4075
C + D C SPC C Y C C + G NC + AC NPC N G+C
Sbjct: 1870 CDV-DDPCTSSPCPPNSRCHDAWE-DYSCVCDKGYLGINC---VDACHLNPCENMGACVR 1924
Query: 4076 ---DPIGNTFICNCKAGLTGVTCEEDIN 4100
P G ++C C G CE ++
Sbjct: 1925 SPGSPQG--YVCECGPSHYGPYCENKLD 1950
Score = 45.1 bits (105), Expect = 0.002
Identities = 32/113 (28%), Positives = 53/113 (46%), Gaps = 9/113 (7%)
Query: 4060 EITACFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGS 4119
+ C N +G + D G FI N T C N C+ C+NGG+CVN +
Sbjct: 1616 QFVGCMRNLSVDGKNVDMAG--FIAN---NGTREGCAARRNFCDGRRCQNGGTCVNRWNM 1670
Query: 4120 FLCNCTPGYVGQYCGLRPVVVPNIQAGHSYVGKEELIGIAVVLFVIFILVVLF 4172
+LC C + G+ C + + P + +G S V +L +++ V + L ++F
Sbjct: 1671 YLCECPLRFGGKNCE-QAMPHPQLFSGESVVSWSDL---NIIISVPWYLGLMF 1719
Score = 32.7 bits (73), Expect = 8.5
Identities = 18/58 (31%), Positives = 20/58 (34%), Gaps = 22/58 (37%)
Query: 4098 DINECEREECENGGSCVNV----------------------FGSFLCNCTPGYVGQYC 4133
D N C RE CEN CV+V C C PG+ G YC
Sbjct: 1303 DDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYC 1360
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 354 bits (908), Expect = 1e-96
Identities = 356/1243 (28%), Positives = 531/1243 (42%), Gaps = 125/1243 (10%)
Query: 2335 DYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVF 2394
D FH+ +G+I TAR LD E H + ++ L + V V I ++DVND+ P F
Sbjct: 114 DDFHVHPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRF 167
Query: 2395 NQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDR--------------- 2439
+ VSEL+P G A D D+ F Y+++ +D
Sbjct: 168 PLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRT 227
Query: 2440 -----TSFLMDSKSGVITLSNHRKQRME----PLYSLNVSVSDG---LFTSTAQVHIRVL 2487
+ L S S + L +R++ + L + DG T V +RVL
Sbjct: 228 PGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVL 287
Query: 2488 GANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAI------------ 2535
N P F Q Y A VRE+ G +V VRATD D G G + Y++
Sbjct: 288 DENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGG 347
Query: 2536 --INDFAKDRFLIDSNGQVITTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRV--IV 2590
+ D A F ++ V+ R LDRE + + V A DGG TVRV V
Sbjct: 348 GALGDAAY--FAVEELSGVVRVWRPLDRE--AQAWHQLVVEARDGGAEPEVATVRVSIAV 403
Query: 2591 VDENDNAPQ----FMTVEYRASVRADVGRGHLVTQVQAIDPD------DGANSRITYSLY 2640
+D NDN P F+T A V G V +V D D D A + L
Sbjct: 404 LDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGL- 462
Query: 2641 SEASVSV---------ADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSL 2691
+ S+S+ A L P ++ +G ++ + + A D G P +
Sbjct: 463 GDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
Query: 2692 IPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILP-----SQNVW--FSTVN 2744
+ + V P F+Q Y +++E A G+ V + S + W ++ V
Sbjct: 523 ETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQ 582
Query: 2745 GERPEN------------NKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKV 2792
P N G F I+ E+G I + LDRE A KV A L +
Sbjct: 583 LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQ-DLGEP 641
Query: 2793 DIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYS 2852
+ T V I V D+NDN+P+F Y+ I E PVG QV A D D G G + YS
Sbjct: 642 PLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYS 701
Query: 2853 LHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDP-TFTFSVVASDLGEAFSLSSTALVS 2911
L+ + +AF ID + G I +D+D E DP T+ V A D G LS+ A V
Sbjct: 702 LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG---GLSAQAFVR 758
Query: 2912 VRVTDINDNAPVFAQEVYRGNVKESDPPG-EVVAVLSTWDRDTSDVNRQVSYHITGGNPR 2970
V + D+NDN PVF Y ++ + PG E++ VL+T D+D S + V+Y + GN
Sbjct: 759 VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLAT-DQD-SGIYGTVAYELIPGNVS 816
Query: 2971 GRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDG---LFVTQAMVEVSVSDVNDNSP 3027
F + + +Y+ PL E L ++A DG V A V + +
Sbjct: 817 SLFTID--STTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPA 874
Query: 3028 VCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLY-GSGNSEFFLDPESGELK 3086
++ YT L+ ED+P + I V A++ + S+ I Y + G +F + P G ++
Sbjct: 875 EFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIR 933
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSN-IHLILEDVNDNPPVFSSDHYNTCVYENTA 3145
T LD E PV L +A G C S +++ + DVNDN P F + + T
Sbjct: 934 TRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTP 993
Query: 3146 TKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISV 3205
L +A D D G N + YS+A GVF+ID + G++ L L +Q +++
Sbjct: 994 PGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
Query: 3206 RATDQSPGQSLSSLTTVTITVLDINDNPP--VFERRDYLVTVPEDTSPGTQVLAVFATSK 3263
RA DQ G + V V++ ++ P FE Y V V E SP TQ+L A
Sbjct: 1054 RAEDQ--GVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPL 1111
Query: 3264 DIGTNAE-ITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEA---KDGGTP 3319
A + Y + + F I P TG I + DYE + + V A +DG
Sbjct: 1112 GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQ 1171
Query: 3320 ALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFS 3379
+S TV + + D NDN P F DV + E + + + A D+DS NGQ+ +
Sbjct: 1172 NVST--TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYF 1229
Query: 3380 IVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDV 3439
+++ + F ++P G + LDRE + + V D G P ++T V + ++D+
Sbjct: 1230 LLSDGKF--FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDI 1287
Query: 3440 NDNSPVF---TPANYTAV-IQENKPVGTSILQLVVTDRDSFHN 3478
NDN P F P V + E +PV + + D D +N
Sbjct: 1288 NDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 1330
Score = 346 bits (888), Expect = 3e-94
Identities = 352/1270 (27%), Positives = 546/1270 (42%), Gaps = 143/1270 (11%)
Query: 763 FTISDGNTDSC----FNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLT 818
F +S+ + DS F++ +TG ++ +DRE D Y + LG + +
Sbjct: 101 FFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSF-VAATLLGAVVQ-----VE 154
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ--- 875
I V D ND+SP F DS +++ E S GT A D D G Y+++ +
Sbjct: 155 IRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPK 214
Query: 876 -------------------QFAINSSTGI----VYVADQLDRESKANYSLKIEARDKAES 912
SS+ + + + +LDRE A + L+IEA D
Sbjct: 215 DPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP 274
Query: 913 GQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVR 972
+ V L+V D ND P F Y V ED G + + D DLG G VR
Sbjct: 275 RRTGLLSVELRVL--DENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVR 332
Query: 973 YSL-------VNDYNGR------FEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPV 1019
YS+ G F +++ SG +R+ + LD E Q ++ L V A+D G
Sbjct: 333 YSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEP 392
Query: 1020 SLSSVSFVEVEVVDVNEN---LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRD- 1075
+++V V + V+DVN+N +H + + V V E +R G V +V+ D D +
Sbjct: 393 EVATVR-VSIAVLDVNDNRPAIHVLFLTEGGVA-RVSEGARPGDYVARVSVSDADGDWEK 450
Query: 1076 -----GEIQYSIRDGS-------GLGRFSI--DDESGV--ITAADILDRETMGSYWLTVY 1119
GE+ + DGS G G F++ GV + LDRE+ Y L +
Sbjct: 451 EDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLV 510
Query: 1120 ATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSS 1179
ATD G PL + + + V D+ND PL S+ Y V E + V+ + A D D +
Sbjct: 511 ATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAG 570
Query: 1180 NEKLTYRITS---------GNPQN----------FFAINIKTGLITTTSRKLDREQQAEH 1220
++ R T G+ Q+ FAI+ ++G I+T R LDRE Q
Sbjct: 571 SDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTI-RTLDREVQEAV 629
Query: 1221 FLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFA 1280
L+V D G P +T V + V D NDN+P F +VY + E G + A
Sbjct: 630 ELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEH--APVGHCFLQVTA 687
Query: 1281 FDRDEGPNAEISYSIVDG----NDDGKFFIDPKTGMVSSRKQFTA----GSYDILTIKAV 1332
D D G I YS+ DG F IDP G + + +YD+L ++A
Sbjct: 688 SDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL-VEAK 746
Query: 1333 DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANT- 1391
D G + R+ +E + P P T+ + E+ TEI+ V++ +
Sbjct: 747 DGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD----ETQPGTEIINVLATDQDSGI 802
Query: 1392 --PLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDG---TNVAVTQV 1446
+ ++++ GN S F + G I + PL + + ++ V DG T V V
Sbjct: 803 YGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADV 862
Query: 1447 FIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISM 1506
I + EF +P Y + EDV D+ I ++A + + + SS D
Sbjct: 863 TIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGG- 921
Query: 1507 RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYF 1566
KF I P G + T + LDHE Q +L + + P + V + V D ND+ P F
Sbjct: 922 -KFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSS-TEVNITVMDVNDNHPAF 979
Query: 1567 TNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITIC 1626
E + ++ G+A+ A D+D G N + Y+I + G +F I+ LG++ +
Sbjct: 980 LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLN 1038
Query: 1627 KEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHP-KFIHKDYQAEVNENVD 1685
+ L+++ DQG P +A ++ + + ++S F H YQ EV+E++
Sbjct: 1039 GSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLS 1098
Query: 1686 IGTSVILISAI------SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQL 1739
T ++ A + S L Y ++ + +F I PY+G I ++ DYE T +Y
Sbjct: 1099 PMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNF 1158
Query: 1740 IIQA-TNMAGMASNA--TVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPL 1796
+ A G N TV +++ DENDN+P FL + E+ ++
Sbjct: 1159 RVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGK------ 1212
Query: 1797 VIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDS 1856
I A D DS +N L+Y ++ KFF ++ +TG + LD E H V V D
Sbjct: 1213 -ITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDR 1269
Query: 1857 GSPQLTAESPVEVNIEVTDVNDNPPVFTQAV----FETILLLPTYVGVEVLKVSATDPDS 1912
GSP A V V+ VTD+NDN P F Q + +L V + V V A DPD
Sbjct: 1270 GSPPRNATMAVYVS--VTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDE 1327
Query: 1913 EVPPELTYSL 1922
E+TYS+
Sbjct: 1328 GNNAEVTYSV 1337
Score = 338 bits (868), Expect = 6e-92
Identities = 356/1283 (27%), Positives = 540/1283 (42%), Gaps = 154/1283 (12%)
Query: 420 FKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDA 479
F ++P +G+I TAR L+ +++ Y G + QV I + D NDH+P F
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAV-VQVEIRVNDVNDHSPRFPLDSLQL 174
Query: 480 YVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-------FVINQFT------- 525
V+E P GT+ A D D G Y++ + LP F + T
Sbjct: 175 DVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSP 234
Query: 526 ---GVISTTEELDF-------ESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNS 575
G S E LD +R + A D G P R ++V +R+ + NDN
Sbjct: 235 LLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP-RRTGLLSVELRVLDENDNP 293
Query: 576 PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQL 635
P+FE+ + + D G + V A D D L P+ V
Sbjct: 294 PVFEQDEYRAAVREDAQPGAEVCRVRATDRD-------------------LGPNGFVRYS 334
Query: 636 KKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEK 695
++ G +G G L D + L G V RE + +L
Sbjct: 335 VRARQVPGAGSG----------GGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQL--- 381
Query: 696 LLIKAKANGK------LNLEDGFLDFYSINRQGPYFDKSFPSD---VAVKEDLPVGANIL 746
+++A+ G + + LD +N P F ++ V E G +
Sbjct: 382 -VVEARDGGAEPEVATVRVSIAVLD---VNDNRPAIHVLFLTEGGVARVSEGARPGDYVA 437
Query: 747 KIKAYDADSGFNGKVLFT--ISDGNTDSCFNIDMETGQ---------------LKVLMPM 789
++ DAD + + T + G D ++ +E G+ L V P+
Sbjct: 438 RVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPL 497
Query: 790 DREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTE 849
DRE DLY L + D G+P S+ L + V D ND P+F Q Y ++ E++ GT
Sbjct: 498 DRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTV 557
Query: 850 IIQVEARDKD---------------------LGSNGEVTYSVLTDTQQFAINSSTGIVYV 888
++ V A D D LGS FAI+S +G +
Sbjct: 558 VMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIST 617
Query: 889 ADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLED 948
LDRE + LK+ A+D E +V++ V DDVND P F Y+ + E
Sbjct: 618 IRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITV--DDVNDNEPIFWRQVYNATIAEH 675
Query: 949 LPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNG-----RFEIDKASGAIRLSKELDYEKQ 1003
PVG + D D GL G + YSL + + F ID G I +S+++D E+
Sbjct: 676 APVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERD 735
Query: 1004 QF-YNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSV 1062
Y+L V AKD G LS+ +FV V++ DVN+N P F V S+ + ++ GT +
Sbjct: 736 PATYDLLVEAKDGG---GLSAQAFVRVDLEDVNDN--HPVFNPSTYVTSISDETQPGTEI 790
Query: 1063 LQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATD 1122
+ V A D+DSG G + Y + G+ F+ID +G+I L + L V A D
Sbjct: 791 INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQD 850
Query: 1123 RGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEK 1182
G + +V I + P Y +V E+ P+D + ++A +P +SS E
Sbjct: 851 GGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSS-EP 909
Query: 1183 LTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVV 1242
+ YRI+SG+ F+I+ + G I T + LD E Q L V G +P S+ V +
Sbjct: 910 IFYRISSGDLGGKFSIHPRLGTIRTR-KPLDHETQPVVVLTVQAQLGS-APACSSTEVNI 967
Query: 1243 QVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDG 1302
V+D NDN P F +I++ + G +Y A A DRD G N I YSI G
Sbjct: 968 TVMDVNDNHPAFLRTSDEIRISQTTPP--GTALYLARAEDRDSGRNGLIRYSIASPQP-G 1024
Query: 1303 KFFIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPL 1360
F ID G++ AG LT++A D G +++ L + I+K SP
Sbjct: 1025 VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVV-IEKREHSP-SW 1082
Query: 1361 TFDEPFYNFTVMES-DRVTEIVGV----VSVQPANTPLWFDIVGGNFDSAFDAEKGVGTI 1415
TF+ Y V ES +T+++ + Q A +PL + + + F G I
Sbjct: 1083 TFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWI 1142
Query: 1416 VIAKPLDAEQRSIYNMSVEV---TDG--TNVAVTQVFIKVLDNNDNGPEFSQPNYDVTIS 1470
+ + D E YN V DG NV+ T V ++V D NDN P F + +
Sbjct: 1143 YLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT-VIVRVWDENDNSPTFLHDVLFLKVE 1201
Query: 1471 EDVLPDTEILQIEATDRD--EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEA 1528
E +P I +I A D D + +L Y + S + F+++P+TG L LD E
Sbjct: 1202 ESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD-----GKFFKMNPNTGELINWVALDREH 1256
Query: 1529 QDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPL----YEASVFESAALGSA 1584
+ H + ++V D+ P R V V+V D ND+ P+F L V E +
Sbjct: 1257 RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNML 1316
Query: 1585 VLQVTALDKDKGENAELIYTIEA 1607
V V A D D+G NAE+ Y++ +
Sbjct: 1317 VTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 338 bits (867), Expect = 7e-92
Identities = 335/1171 (28%), Positives = 513/1171 (43%), Gaps = 121/1171 (10%)
Query: 2550 GQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASV 2609
G + T RLDRE D FV A G V + V D ND++P+F + V
Sbjct: 123 GIIRTARRLDRERR---DHYSFVAATLLGA---VVQVEIRVNDVNDHSPRFPLDSLQLDV 176
Query: 2610 RADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASV------------------------ 2645
G A DPD G S Y+L + +
Sbjct: 177 SELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLL 236
Query: 2646 --SVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPET 2703
S + L +D +V ++ + ++A DGG P + L+ V + VL
Sbjct: 237 PGSSSPLEPLD-----LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDEND 291
Query: 2704 FLPSFTQSQYSFTIAEDTAIGSTVDTLRIL-----PSQNVWFSTVNGERPENNKGG---- 2754
P F Q +Y + ED G+ V +R P+ V +S + P GG
Sbjct: 292 NPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALG 351
Query: 2755 ---IFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNK 2811
F +E+ +G +++ + LDRE A+H V V TV V I VLD+NDN+
Sbjct: 352 DAAYFAVEELSGVVRVWRPLDREAQ-AWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNR 410
Query: 2812 P----VFETSSYDTIIMEGMPVGTKLTQVRAIDMD--WGANGQVTYSLHSDSQPEKVMEA 2865
P +F T + EG G + +V D D W + T L + +
Sbjct: 411 PAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI--S 468
Query: 2866 FNIDSNTGWISTLKD-------------LDHETDPTFTFSVVASDLGEAFSLSSTALVSV 2912
+++ G + L LD E+ + +VA+D G LS+ + +
Sbjct: 469 LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSP-PLSTEETLLL 527
Query: 2913 RVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNR--------QVSYHI 2964
RV D+ND P+F+Q+ Y+ +V E+ PG VV +S D D + + Q+S
Sbjct: 528 RVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPC 587
Query: 2965 TGGNPRGRF--------ALGLVQSEWKVYVKRPLDREEQDIYFLNITATD----GLFVTQ 3012
G+ + + + + + R LDRE Q+ L + A D L T
Sbjct: 588 NLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT- 646
Query: 3013 AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSG 3072
+V ++V DVNDN P+ + Y A + E P L+V+A DAD G G+I YSLY
Sbjct: 647 CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706
Query: 3073 NS-----EFFLDPESGELKTLALLDRERIPV-YSLMAKATDGGGRFCQSNIHLILEDVND 3126
S F +DP G++ +DRER P Y L+ +A DGGG Q+ + + LEDVND
Sbjct: 707 LSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVND 766
Query: 3127 NPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLAD-SAGGVFSIDSSSG 3185
N PVF+ Y T + + T + V A D D GI V Y L + +F+IDS++G
Sbjct: 767 NHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 826
Query: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTT--VTITVLDINDNPPVFERRDYLV 3243
II L PL + ++ ++ V A D G L+++ VTI + P FER Y
Sbjct: 827 IIYLTLPLSHLESTTLSLMVSAQD---GGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 883
Query: 3244 TVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYEL 3303
V ED P + + + ++ I Y I SG+ GKF I+P+ G I + LD+E
Sbjct: 884 LVYEDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHET 942
Query: 3304 CKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILL 3363
L V+A+ G PA S+ VNI + DVNDN P F + IS+ G ++ L
Sbjct: 943 QPVVVLTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001
Query: 3364 IAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGI 3423
AED DS NG I +SI + + F +D LG++ + L +L ++A D G+
Sbjct: 1002 RAEDRDSGRNGLIRYSIAS-PQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 1060
Query: 3424 PAMSSTATVNIDISDVNDNSPVFTPAN--YTAVIQENKPVGTSILQLVVTDRDSFHNGPP 3481
++ + + I + ++SP +T + Y + E+ T +LQ P
Sbjct: 1061 HPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 1119
Query: 3482 FSFSILSGNEEEEFVLDPHG---ILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIR 3538
+S+ + F + P+ LR ++ T++ + + + G Q VS T I
Sbjct: 1120 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI- 1178
Query: 3539 VRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQD--MYDVLTFALKSEQKSLF 3596
VRV +E+ + PT + +F+ E P GVIGKI A D D L + L S+ K F
Sbjct: 1179 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK-FF 1237
Query: 3597 KVNSHDGKIIALGGLD---SGKYVLNVSVSD 3624
K+N + G++I LD G + + V V+D
Sbjct: 1238 KMNPNTGELINWVALDREHRGHHEMTVLVTD 1268
Score = 318 bits (814), Expect = 1e-85
Identities = 331/1211 (27%), Positives = 519/1211 (42%), Gaps = 133/1211 (10%)
Query: 1084 DGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVND 1143
D L F + ++G+I A LDRE Y V AT G V ++V I V DVND
Sbjct: 109 DSPLLDDFHVHPDTGIIRTARRLDRERRDHYSF-VAATLLGAV-----VQVEIRVNDVND 162
Query: 1144 NAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSS--SNEKLTYRITSGNPQN----FFA 1197
++P V E SP + A DPD+ S + T S P++ FF
Sbjct: 163 HSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQ 222
Query: 1198 INIKT-----------------GLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWV 1240
+ +T L R+LDRE+ A H L++ DGG + + V
Sbjct: 223 LRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSV 282
Query: 1241 VVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSI----V 1296
++VLDENDN P F + Y+ + R+ + G + R A DRD GPN + YS+ V
Sbjct: 283 ELRVLDENDNPPVFEQDEYRAAV--REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQV 340
Query: 1297 DG--------NDDGKFFIDPKTGMVSSRKQF--TAGSYDILTIKAVDNGRPQKSSTARLH 1346
G D F ++ +G+V + A ++ L ++A D G + +T R+
Sbjct: 341 PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVS 400
Query: 1347 IEWIKKPPPSP-IPLTFDEPFYNFTVMESDRVTEIVGVVSVQPA---------------- 1389
I + P I + F V E R + V VSV A
Sbjct: 401 IAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGV 460
Query: 1390 ---NTPLWFDIVGGNFDSAF--DAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVT 1444
+ + + GG D A GV + + PLD E R +Y + + TD + ++
Sbjct: 461 GLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLS 520
Query: 1445 ---QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHK----LSYTV 1497
+ ++V D ND P FSQ +Y ++SE P T ++ + A+D DE L YTV
Sbjct: 521 TEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTV 580
Query: 1498 -----HSSIDSISMR---------KFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEF 1543
++ S+ + F ID +G + T LD E Q+ L ++ +D
Sbjct: 581 VQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGE 640
Query: 1544 PYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIY 1603
P V + V+D ND+ P F +Y A++ E A +G LQVTA D D G + Y
Sbjct: 641 PPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEY 700
Query: 1604 TIEAG----NTGNMFKIEPVLGIITICKEPDM-TTMGQFVLSIKVTDQGSPPMSATAIVR 1658
++ G F+I+P G I + ++ D + L ++ D G +SA A VR
Sbjct: 701 SLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFVR 758
Query: 1659 ISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGDINGI 1713
+ + +++HP F Y +++ GT +I + A Q T+ YE+ G+++ +
Sbjct: 759 VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSL 818
Query: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMAS--NATVNIQIVDENDNAPVFLF 1771
FTI+ +G+I L + +++ L++ A + G+ + NA V I I F
Sbjct: 819 FTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFER 878
Query: 1772 SQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTG 1831
+Y+ + E P ++SP+ N + + Y+I F++ G
Sbjct: 879 PKYTFLVYEDVP--------EDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG 930
Query: 1832 AIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETI 1891
IRT LDHET V + +P A S EVNI V DVNDN P F + E
Sbjct: 931 TIRTRKPLDHETQPVVVLTVQAQLGSAP---ACSSTEVNITVMDVNDNHPAFLRTSDEIR 987
Query: 1892 LLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKNNNL---SK 1948
+ T G + A D DS + YS+ F ID GVL + N +L +
Sbjct: 988 ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFL-NGSLGAGEQ 1046
Query: 1949 DHYMLIVKVSDGKFYSTS----MVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIV 2004
L ++ D + + + ++ K F Y +SE+ + +T++
Sbjct: 1047 RELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQT 1106
Query: 2005 NA--VG-NRLNEPLKYSILNP---GNKFKIKSTSGVIQTTGVPFDREEQELYELVVEA-S 2057
A +G R PL+YS L P F I+ +G I FD E + Y V A
Sbjct: 1107 QAHPLGPQRAASPLRYS-LEPSVDSAMFGIRPYTGWIYLRR-QFDYESTQTYNFRVFAWI 1164
Query: 2058 RELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNG 2117
E L+ V V + D NDNSP F+ + V+ P +I ++TAID D G NG
Sbjct: 1165 PEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNG 1224
Query: 2118 EVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKP--SLSTSVELP 2175
++ Y L D F++NPN+G +I A + + + +T+L D G P + + +V +
Sbjct: 1225 QLLYFLLSDGKFFKMNPNTGELINWVALDREHRG-HHEMTVLVTDRGSPPRNATMAVYVS 1283
Query: 2176 ITIVNKAMPVF 2186
+T +N P F
Sbjct: 1284 VTDINDNRPFF 1294
Score = 317 bits (813), Expect = 1e-85
Identities = 347/1259 (27%), Positives = 519/1259 (41%), Gaps = 145/1259 (11%)
Query: 2026 FKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFV 2085
F + +G+I+T DRE ++ Y V L A V V + + D+ND+SP F
Sbjct: 116 FHVHPDTGIIRTAR-RLDRERRDHYSFVAAT------LLGAVVQVEIRVNDVNDHSPRFP 168
Query: 2086 GLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL-------QDDYGHF-------- 2130
V + PGT A D D G Y L +D G F
Sbjct: 169 LDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTP 228
Query: 2131 -----EINPNSGN-------VILKEAFNSDLSNIEYGVTILAKDGGKPSLS--TSVELPI 2176
+ P S + V+L+ + + + + I A DGG+P + SVEL +
Sbjct: 229 GPLPSPLLPGSSSPLEPLDLVLLRRLDREEAA--AHRLQIEAWDGGRPRRTGLLSVELRV 286
Query: 2177 TIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE--GQGIIYIIID---------- 2224
N PVF++ Y A+V ED + + + AT + G + +
Sbjct: 287 LDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG 346
Query: 2225 ----GDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVT---VDLLV 2277
GD F ++ +GV++V PLD E + ++L + A D GA EV V + V
Sbjct: 347 GGALGDA-AYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDG--GAEPEVATVRVSIAV 403
Query: 2278 NDVNDNPP----IFDQPTYNTTLSEASLIGTPVLQVVSIDADS--ENNKMVHYQIVQDTY 2331
DVNDN P +F +SE + G V +V DAD E ++
Sbjct: 404 LDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLG 463
Query: 2332 NSTDYFHIDSSSG-------------LILTARMLDHELVQHCTLKVRSIDSGFPSLSSEV 2378
+ + ++ G + LD E L + + D+G P LS+E
Sbjct: 464 DGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEE 523
Query: 2379 LVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDR--LEYSIL-- 2434
+ + ++D+ND PP+F+Q Y++ VSE A G V V ASDAD + D L Y+++
Sbjct: 524 TLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583
Query: 2435 ---------------SGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD---GLF 2476
+ SF +DS+SG I+ + ++ L V D
Sbjct: 584 SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPL 643
Query: 2477 TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAII 2536
++T V I V N P F + Y A + E+ G + V A+D D G YG I Y++
Sbjct: 644 SATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY 703
Query: 2537 NDF----AKDRFLIDSN-GQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVV 2591
+ F A F ID + GQ+ ++ +DRE + V A DGGG + VRV +
Sbjct: 704 DGFLSYEAPQAFRIDPHDGQICVSQDIDRERD-PATYDLLVEAKDGGGLSAQAFVRVDLE 762
Query: 2592 DENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLL 2651
D NDN P F Y S+ + G + V A D D G + Y L +V+ L
Sbjct: 763 DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG---NVSSLF 819
Query: 2652 EIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQS 2711
ID G + + L++T LS V A DGG V IH+ F +
Sbjct: 820 TIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERP 879
Query: 2712 QYSFTIAEDTAIGSTVDTLR----ILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKL 2767
+Y+F + ED S + T++ + S+ +++ +G+ GG F I GTI+
Sbjct: 880 KYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDL-----GGKFSIHPRLGTIRT 934
Query: 2768 DKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGM 2827
K LD ET P V A L + +V+I V+D+NDN P F +S + I +
Sbjct: 935 RKPLDHETQPVVVLTVQAQ--LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
Query: 2828 PVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDP 2887
P GT L RA D D G NG + YS+ S QP F ID G + L
Sbjct: 993 PPGTALYLARAEDRDSGRNGLIRYSIASP-QPG----VFAIDRALGVLFLNGSLGAGEQR 1047
Query: 2888 TFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAP--VFAQEVYRGNVKESDPPGEVVAV 2945
T ++ A D G + LV V + +++P F VY+ V ES P +
Sbjct: 1048 ELTLTLRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQ 1105
Query: 2946 LSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITA- 3004
+ Y + F + + W +Y++R D E Y + A
Sbjct: 1106 TQAHPLGPQRAASPLRYSLEPSVDSAMFGIR-PYTGW-IYLRRQFDYESTQTYNFRVFAW 1163
Query: 3005 --TDGLFVT-QAMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGS 3060
DG V V V D NDNSP V + + +P +I K++A D D G
Sbjct: 1164 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQG-VIGKITAIDMDSGK 1222
Query: 3061 NGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGG--RFCQSNIH 3118
NG + Y L G F ++P +GEL LDRE + + TD G R ++
Sbjct: 1223 NGQLLYFLLSDGKF-FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVY 1281
Query: 3119 LILEDVNDNPPVFSS----DHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADS 3173
+ + D+NDN P F + V E L+T V A DPD G N +V YS++ +
Sbjct: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSA 1340
Score = 288 bits (737), Expect = 9e-77
Identities = 307/1144 (26%), Positives = 495/1144 (43%), Gaps = 178/1144 (15%)
Query: 144 VNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNK--- 200
V ++VLD ND P+F Y + E V +V ATD D+G NG Y + +
Sbjct: 282 VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVP 341
Query: 201 -----------VDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSST 249
F+V SGV+ + L+ + + + L + A D G + +T
Sbjct: 342 GAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAE-----PEVAT 396
Query: 250 AKLYVHIERINEHAPTIHV-------VTHVPFSLEKEPTYAVVTVDDLD------DGANG 296
++ + + +N++ P IHV V V A V+V D D D A G
Sbjct: 397 VRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATG 456
Query: 297 EIE-----------------SVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPY 339
E+ +++ G P FFL EG +D ES
Sbjct: 457 ELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGP------------LDRESRDL 504
Query: 340 GYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVV---- 395
Y L L A D GSP + + D P+ F ++ Y S+SE + PG VV
Sbjct: 505 -YELLLVATDAGSPPLSTEETLLLRVADLNDQPPL-FSQQHYKASVSEAAAPGTVVMWVS 562
Query: 396 ----------------AIVKLSPEPIDV----EYKLSPGEDAVYFKINPRSGLIVTARPL 435
+V+LS P ++ + E F I+ SG I T R L
Sbjct: 563 ASDADEAGSDHAWLRYTVVQLSA-PCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTL 621
Query: 436 NTVKKEVYKLEVTNK---EGDLKAQ--VTISIEDANDHTPEFQQPLYDAYVNESVPVGTS 490
+ +E +L+V + E L A V+I+++D ND+ P F + +Y+A + E PVG
Sbjct: 622 DREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHC 681
Query: 491 VLTVSASDKDKGENGYITYSIASLNLL-----PFVINQFTGVISTTEELDFESSPEIYRF 545
L V+ASD D G G+I YS+ L F I+ G I ++++D E P Y
Sbjct: 682 FLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDL 741
Query: 546 IVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDI 605
+V A D G ++ V + + +VNDN P+F IS + G I V A D
Sbjct: 742 LVEAKDGGGL---SAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQ 798
Query: 606 DE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLAD 663
D V Y++I GN F ++ +G++ L +L S +++ +L ++A DG L
Sbjct: 799 DSGIYGTVAYELIPGNVSSLFTIDSTTGIIYL--TLPLSHLESTTLSLMVSAQDGGGLT- 855
Query: 664 PMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGP 723
+V++ V+ F +T +A E+ P
Sbjct: 856 ------AVINADVTIHIF---QTTLAPAEFER---------------------------P 879
Query: 724 YFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQL 783
+ DV ED P+G +KA + + + + + IS G+ F+I G +
Sbjct: 880 KYTFLVYEDVP--EDSPIGT----VKAREPLNS-SEPIFYRISSGDLGGKFSIHPRLGTI 932
Query: 784 KVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILES 843
+ P+D E + +L + LG+ S + I V D NDN P F++ S + I ++
Sbjct: 933 RTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQT 991
Query: 844 SGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ-FAINSSTGIVYVADQLDRESKANYSL 902
+ GT + A D+D G NG + YS+ + FAI+ + G++++ L + +L
Sbjct: 992 TPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTL 1051
Query: 903 KIEARDKAESGQQLFSVVTLKVFLDDVNDCSPA--FIPSSYSVKVLEDLPVGTVIAWLET 960
+ A D+ Q V+T+ + + + SP+ F Y V+V E L T + +
Sbjct: 1052 TLRAEDQGVHPQAALLVLTVVI---EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 1108
Query: 961 HDPDLGLGGQ-----VRYSLVNDYNGR-FEIDKASGAIRLSKELDYEKQQFYNLTVRA-- 1012
H LG Q +RYSL + F I +G I L ++ DYE Q YN V A
Sbjct: 1109 HP----LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI 1164
Query: 1013 KDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDS 1072
+ G ++S+ V V V D N+N +P F + V+E+ + ++TA D DS
Sbjct: 1165 PEDGFLQNVSTT--VIVRVWDENDN--SPTFLHDVLFLKVEESPVPQGVIGKITAIDMDS 1220
Query: 1073 GRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTI 1132
G++G++ Y + F ++ +G + LDRE G + +TV TDRG P +T+
Sbjct: 1221 GKNGQLLYFLLSDGKF--FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
Query: 1133 EVYIEVEDVNDNAPLTSEPI----YYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRIT 1188
VY+ V D+NDN P + + + V+E P ++ V + A+DPD +N ++TY ++
Sbjct: 1279 AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
Query: 1189 SGNP 1192
S P
Sbjct: 1339 SARP 1342
Score = 283 bits (723), Expect = 4e-75
Identities = 305/1110 (27%), Positives = 467/1110 (42%), Gaps = 90/1110 (8%)
Query: 2240 LKVVSPLDYEVTSAYKLTIRASDALTGARAEV-TVDLLVNDVNDNPPIFDQPTYNTTLSE 2298
L ++ LD E +A++L I A D R + +V+L V D NDNPP+F+Q Y + E
Sbjct: 248 LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVRE 307
Query: 2299 ASLIGTPVLQVVSIDADSENNKMVHYQIVQ----------DTYNSTDYFHIDSSSGLILT 2348
+ G V +V + D D N V Y + YF ++ SG++
Sbjct: 308 DAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRV 367
Query: 2349 ARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYE----SYVS 2404
R LD E L V + D G + V V I + DVNDN P + L + VS
Sbjct: 368 WRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVS 427
Query: 2405 ELAPRGHFVTCVQASDADSSDFDR----------------LEYSILSGNDRTSFLMDSKS 2448
E A G +V V SDAD D+++ + S+ G + L
Sbjct: 428 EGARPGDYVARVSVSDADG-DWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486
Query: 2449 GVITL--SNHRKQRMEPLYSLNVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTYVA 2503
GV L + LY L + +D ++ + +RV N P FSQ Y A
Sbjct: 487 GVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKA 546
Query: 2504 EVRENVAAGTKVIHVRATDGDPG--TYGQISYAIINDFAK-----------------DRF 2544
V E A GT V+ V A+D D + + Y ++ A F
Sbjct: 547 SVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSF 606
Query: 2545 LIDSNGQVITTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTV 2603
IDS I+T R LDRE ++ + + L + C V + V D NDN P F
Sbjct: 607 AIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666
Query: 2604 EYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSE-ASVSVADLLEIDPDNGWMVT 2662
Y A++ GH QV A D D G I YSLY S IDP +G +
Sbjct: 667 VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 726
Query: 2663 KGNFNQLKN-TVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDT 2721
+ ++ ++ V+A DGG + + V + + P F S Y +I+++T
Sbjct: 727 SQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNH--PVFNPSTYVTSISDET 784
Query: 2722 AIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
G+ + + + + TV E N +F I+ TG I L L S
Sbjct: 785 QPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSL 844
Query: 2782 KVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDM 2841
V+A + V DV I + FE Y ++ E +P + + V+A +
Sbjct: 845 MVSAQDG-GGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE- 902
Query: 2842 DWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEA 2901
++ + Y + S K F+I G I T K LDHET P +V A LG A
Sbjct: 903 PLNSSEPIFYRISSGDLGGK----FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSA 957
Query: 2902 FSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVS 2961
+ SST V++ V D+NDN P F + + ++ PPG + + DRD S N +
Sbjct: 958 PACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRD-SGRNGLIR 1015
Query: 2962 YHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQA--MVEVSV 3019
Y I P G FA+ ++ +++ L EQ L + A D QA +V V
Sbjct: 1016 YSIASPQP-GVFAID--RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVV 1072
Query: 3020 SDVNDNSP--VCDQVAYTALLPEDIPSNKIILKVSAKD-ADIGSNGYIRYSLYGSGNSEF 3076
+ ++SP + + Y + E + +L+ A + +RYSL S +S
Sbjct: 1073 IEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAM 1132
Query: 3077 F-LDPESGELKTLALLDRERIPVYSLMAKA---TDGGGRFCQSNIHLILEDVNDNPPVFS 3132
F + P +G + D E Y+ A DG + + + + + D NDN P F
Sbjct: 1133 FGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFL 1192
Query: 3133 SDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQP 3192
D V E+ + ++ ++ A+D D G N +++Y L S G F ++ ++G +I
Sbjct: 1193 HDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL-SDGKFFKMNPNTGELINWVA 1251
Query: 3193 LDREQQSSYNISVRATDQ-SPGQSLSSLTTVTITVLDINDNPPVFER----RDYLVTVPE 3247
LDRE + + ++V TD+ SP ++ + V++T DINDN P F + ++ V V E
Sbjct: 1252 LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVT--DINDNRPFFPQCLPGKELHVKVLE 1309
Query: 3248 DTSPGTQVLAVFATSKDIGTNAEITYLIRS 3277
V VFA D G NAE+TY + S
Sbjct: 1310 GQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 282 bits (721), Expect = 6e-75
Identities = 350/1309 (26%), Positives = 531/1309 (40%), Gaps = 161/1309 (12%)
Query: 2192 TASVNEDIRMNTPILSINATSP-----EGQGIIYIIIDGDP---FKQFNIDFDTGVLKVV 2243
T SV+E + +T + I A P EG G ++ D D F++ DTG+++
Sbjct: 70 TLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGF-FLSEDSDDSPLLDDFHVHPDTGIIRTA 128
Query: 2244 SPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIG 2303
LD E Y A T A V V++ VNDVND+ P F + +SE S G
Sbjct: 129 RRLDRERRDHYSFV-----AATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPG 183
Query: 2304 TPVLQVVSIDADSENNKMVHYQIVQDTYNSTD----YFHI--------------DSSSGL 2345
T V+ D D+ Y +VQ + D +F + SSS L
Sbjct: 184 TAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPL 243
Query: 2346 ----ILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYES 2401
++ R LD E L++ + D G P + + V + + D NDNPPVF Q Y +
Sbjct: 244 EPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRA 303
Query: 2402 YVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGN------------DRTSFLMDSKSG 2449
V E A G V V+A+D D + YS+ + D F ++ SG
Sbjct: 304 AVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSG 363
Query: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF---TSTAQVHIRVLGANLYSPA----FSQSTYV 2502
V+ + + + + L V DG +T +V I VL N PA F V
Sbjct: 364 VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGV 423
Query: 2503 AEVRENVAAGTKVIHVRATDGDPGT-------------YGQISYAIINDFAKDRFLIDSN 2549
A V E G V V +D D G S ++ + + F +
Sbjct: 424 ARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPG 483
Query: 2550 GQ-----VITTERLDRENPLEGDVSIFVRALDGGGR--TTFCTVRVIVVDENDNAPQFMT 2602
G + LDRE+ + + A D G +T T+ + V D ND P F
Sbjct: 484 GPPGVFFLCVEGPLDRES--RDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQ 541
Query: 2603 VEYRASVRADVGRGHLVTQVQAIDPDDGANSR--ITYSLYS-EASVSVADL--------- 2650
Y+ASV G +V V A D D+ + + Y++ A ++ L
Sbjct: 542 QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601
Query: 2651 ----LEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLP 2706
ID ++G + T ++ + V A D G P + V I V P
Sbjct: 602 CGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEP 661
Query: 2707 SFTQSQYSFTIAEDTAIGSTVDTLRILPSQN-----VWFSTVNG----ERPENNKGGIFV 2757
F + Y+ TIAE +G + + + + +S +G E P+ F
Sbjct: 662 IFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQ-----AFR 716
Query: 2758 IEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETS 2817
I+ G I + + +DRE PA + + + V VD++ D+NDN PVF S
Sbjct: 717 IDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE--DVNDNHPVFNPS 774
Query: 2818 SYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWIST 2877
+Y T I + GT++ V A D D G G V Y L P V F IDS TG I
Sbjct: 775 TYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI----PGNVSSLFTIDSTTGIIYL 830
Query: 2878 LKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVT---------DINDNAPVFAQEV 2928
L H T + V A D G TA+++ VT P + V
Sbjct: 831 TLPLSHLESTTLSLMVSAQDGG-----GLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 885
Query: 2929 YRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFA----LGLVQSEWKV 2984
Y +V E P G V A R+ + + + Y I+ G+ G+F+ LG +++
Sbjct: 886 YE-DVPEDSPIGTVKA------REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRT---- 934
Query: 2985 YVKRPLDREEQDIYFLNITATDGLFVTQAMVEVSVS--DVNDNSPVCDQVAYTALLPEDI 3042
++PLD E Q + L + A G + EV+++ DVNDN P + + + +
Sbjct: 935 --RKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTT 992
Query: 3043 PSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLM 3102
P + A+D D G NG IRYS+ F +D G L L +L
Sbjct: 993 PPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLT 1052
Query: 3103 AKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDH--YNTCVYENTA--TKALLTRVQAVD 3157
+A D G + + L ++ + ++ P ++ +H Y V E+ + T+ L T+ +
Sbjct: 1053 LRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLG 1112
Query: 3158 PDIGINRKVVYSLADSA-GGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSL 3216
P + + YSL S +F I +G I L + D E +YN V A G
Sbjct: 1113 PQRAAS-PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQ 1171
Query: 3217 SSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIR 3276
+ TTV + V D NDN P F + V E P + + A D G N ++ Y +
Sbjct: 1172 NVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 1231
Query: 3277 SGNEQGK-FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVN 3335
S GK FK+NP TG + LD E + V D G+P +A V +++TD+N
Sbjct: 1232 S---DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDIN 1288
Query: 3336 DNPPKFSQDVYSAVISEDALVGDSVILLI----AEDVDSQPNGQIHFSI 3380
DN P F Q + + L G V +L+ A+D D N ++ +S+
Sbjct: 1289 DNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 275 bits (704), Expect = 6e-73
Identities = 319/1165 (27%), Positives = 492/1165 (42%), Gaps = 165/1165 (14%)
Query: 429 IVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHTPEFQQPLYDAYVNE 483
+V R L+ + ++L++ +G + V + + D ND+ P F+Q Y A V E
Sbjct: 248 LVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVRE 307
Query: 484 SVPVGTSVLTVSASDKDKGENGYITYSIASLNL-------------LPFVINQFTGVIST 530
G V V A+D+D G NG++ YS+ + + F + + +GV+
Sbjct: 308 DAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRV 367
Query: 531 TEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSP----LFEKVACQGV 586
LD E+ ++ +V A D G+ + V V+I + +VNDN P LF
Sbjct: 368 WRPLDREAQAW-HQLVVEARDGGAE-PEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVAR 425
Query: 587 ISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKN 646
+S G ++ VS D D + K +G ELG G+ +
Sbjct: 426 VSEGARPGDYVARVSVSDADG-DWEKEDEATG-ELGV-------------------GLGD 464
Query: 647 GNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRE---TRVAQKLAEKLLIKAKAN 703
G+ +L + +G+ ++L G F C E R ++ L E LL+ A
Sbjct: 465 GSISLSLEGGEGD---------FALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAG 515
Query: 704 GK-LNLEDGFL-DFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSG----- 756
L+ E+ L +N Q P F + +V E G ++ + A DAD
Sbjct: 516 SPPLSTEETLLLRVADLNDQPPLFSQQHYK-ASVSEAAAPGTVVMWVSASDADEAGSDHA 574
Query: 757 -----------------FNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLL 799
K++ T G + F ID E+G + + +DRE + L
Sbjct: 575 WLRYTVVQLSAPCNLGSLQSKMVHTAECGPS---FAIDSESGAISTIRTLDREVQEAVEL 631
Query: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
+ DLG P S+ L++I V+D NDN P+F + Y+ I E + +G +QV A D D
Sbjct: 632 KVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDAD 691
Query: 860 LGSNGEVTYSVLTD------TQQFAINSSTGIVYVADQLDRE-SKANYSLKIEARDKAES 912
G G + YS+ Q F I+ G + V+ +DRE A Y L +EA+D
Sbjct: 692 SGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGL 751
Query: 913 GQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVR 972
Q F ++V L+DVND P F PS+Y + ++ GT I + D D G+ G V
Sbjct: 752 SAQAF----VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVA 807
Query: 973 YSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEV 1031
Y L+ + + F ID +G I L+ L + + +L V A+D G L++V +V +
Sbjct: 808 YELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGG---GLTAVINADVTI 864
Query: 1032 VDVNENLHTPYFP----DFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSG 1087
L F F V V E+S IGT V AR E I Y I G
Sbjct: 865 HIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGT----VKAR-EPLNSSEPIFYRISSGDL 919
Query: 1088 LGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPL 1147
G+FSI G I LD ET LTV A G P S+ EV I V DVNDN P
Sbjct: 920 GGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPA 978
Query: 1148 ---TSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGL 1204
TS+ I + + +P ++ +AED DS N + Y I S P FAI+ G+
Sbjct: 979 FLRTSDEIR---ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAIDRALGV 1034
Query: 1205 ITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQ--FPEKVYQIK 1262
+ L +Q E L + D G P Q+ + V+ V+++ ++ P F VYQ++
Sbjct: 1035 LFLNG-SLGAGEQRELTLTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVE 1092
Query: 1263 LPE------RDRKKRGEPIYRAFAFDRDEGPN---AEISYSIVDGNDDGKFFIDPKTGMV 1313
+ E + + + P+ GP + + YS+ D F I P TG +
Sbjct: 1093 VSESLSPMTQMLQTQAHPL----------GPQRAASPLRYSLEPSVDSAMFGIRPYTGWI 1142
Query: 1314 SSRKQFTAGSYDILTIKAV----DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNF 1369
R+QF S + ++G Q ST + W + SP TF
Sbjct: 1143 YLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW-DENDNSP---TFLHDVLFL 1198
Query: 1370 TVMESDRVTEIVGVVSVQPANTP-----LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAE 1424
V ES ++G ++ ++ L+F + G F F G ++ LD E
Sbjct: 1199 KVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKF---FKMNPNTGELINWVALDRE 1255
Query: 1425 QRSIYNMSVEVTDGTNV---AVTQVFIKVLDNNDNGPEFSQ----PNYDVTISEDVLPDT 1477
R + M+V VTD + A V++ V D NDN P F Q V + E +
Sbjct: 1256 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNM 1315
Query: 1478 EILQIEATDRDEKH--KLSYTVHSS 1500
+ + A D DE + +++Y+V S+
Sbjct: 1316 LVTTVFAKDPDEGNNAEVTYSVSSA 1340
Score = 274 bits (700), Expect = 2e-72
Identities = 326/1301 (25%), Positives = 535/1301 (41%), Gaps = 152/1301 (11%)
Query: 1464 NYDVTISEDVLPDTEILQIEA---TDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYT 1520
N +++ E + PDT + I A + ++ + S DS + F + P TG++ T
Sbjct: 68 NLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRT 127
Query: 1521 AERLDHEAQDKHILNIMVRDQEFPYRRNLARVI---VNVEDANDHSPYFTNPLYEASVFE 1577
A RLD E +D + F L V+ + V D NDHSP F + V E
Sbjct: 128 ARRLDRERRDHY---------SFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSE 178
Query: 1578 SAALGSAVLQVTALDKDKGENAELIYTIEAGN--------------------------TG 1611
+ G+A A D D G + YT+ + G
Sbjct: 179 LSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPG 238
Query: 1612 NMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKF 1671
+ +EP+ + + + D L I+ D G P + V + V +++ P F
Sbjct: 239 SSSPLEPL--DLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVF 296
Query: 1672 IHKDYQAEVNENVDIGTSVILISAISQST-----LIYEVKDGDING------------IF 1714
+Y+A V E+ G V + A + + Y V+ + G F
Sbjct: 297 EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356
Query: 1715 TINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNAT--VNIQIVDENDNAP----V 1768
+ SGV+ + LD E + +QL+++A + AT V+I ++D NDN P +
Sbjct: 357 AVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVL 416
Query: 1769 FLFSQYSGSLSEAA-PINSIVRSLDNSPLVIRATDADSN----RNALLVYQIVESTAKKF 1823
FL +SE A P + + R + +DAD + A +
Sbjct: 417 FLTEGGVARVSEGARPGDYVAR--------VSVSDADGDWEKEDEATGELGVGLGDGSIS 468
Query: 1824 FTVDSSTGAIRTIAN-------------LDHETIAHFHFHVHVRDSGSPQLTAESPVEVN 1870
+++ G + LD E+ + + D+GSP L+ E +
Sbjct: 469 LSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEE--TLL 526
Query: 1871 IEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPE--LTYSLME---- 1924
+ V D+ND PP+F+Q ++ + G V+ VSA+D D L Y++++
Sbjct: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
Query: 1925 ---GSLD-----------HFLIDSNSGVL-TIKNNNLSKDHYMLIVKVS----DGKFYST 1965
GSL F IDS SG + TI+ + + + V+ + +T
Sbjct: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT 646
Query: 1966 SMVTIMVKEAMDSGLHFTQSFYSTSISENNT--NITKVAIVNAVGNRLNEPLKYSILN-- 2021
+V+I V + D+ F + Y+ +I+E+ + + + L ++YS+ +
Sbjct: 647 CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706
Query: 2022 ----PGNKFKIKSTSGVIQTTGVPFDRE-EQELYELVVEASRELDHLRVARVVVRVNIED 2076
F+I G I DRE + Y+L+VEA ++ L A+ VRV++ED
Sbjct: 707 LSYEAPQAFRIDPHDGQI-CVSQDIDRERDPATYDLLVEA-KDGGGLS-AQAFVRVDLED 763
Query: 2077 INDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL--QDDYGHFEINP 2134
+NDN PVF Y ++ + +PGT I V A D+D G G V Y L + F I+
Sbjct: 764 VNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDS 823
Query: 2135 NSGNVILKEAFNSDLSNIEYGVTILAKDGG--KPSLSTSVELPITIVNKAMPVFDKPFYT 2192
+G + L S L + + + A+DGG ++ V + I A F++P YT
Sbjct: 824 TTGIIYLTLPL-SHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYT 882
Query: 2193 ASVNEDIRMNTPILSINATSP--EGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEV 2250
V ED+ ++PI ++ A P + I Y I GD +F+I G ++ PLD+E
Sbjct: 883 FLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHET 942
Query: 2251 TSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVV 2310
LT++A A + V++ V DVNDN P F + + +S+ + GT +
Sbjct: 943 QPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLAR 1002
Query: 2311 SIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSG 2370
+ D DS N ++ Y I F ID + G++ L + TL +R+ D G
Sbjct: 1003 AEDRDSGRNGLIRYSIASP---QPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG 1059
Query: 2371 FPSLSSEVLVHIYISDVNDNPP-VFNQLIYESYVSE-LAPRGHFVTCVQASDADSSDFDR 2428
++ +++ + I +P F L+Y+ VSE L+P +
Sbjct: 1060 VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASP 1119
Query: 2429 LEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSV---SDGLFTS-TAQVHI 2484
L YS+ D F + +G I L Y+ V DG + + V +
Sbjct: 1120 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV 1179
Query: 2485 RVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRF 2544
RV N SP F +V E+ + + A D D G GQ+ Y +++D K
Sbjct: 1180 RVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD-GKFFK 1238
Query: 2545 LIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVE 2604
+ + G++I LDRE+ ++++ V R V V V D NDN P F
Sbjct: 1239 MNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCL 1298
Query: 2605 YRASVRADVGRGH----LVTQVQAIDPDDGANSRITYSLYS 2641
+ V G LVT V A DPD+G N+ +TYS+ S
Sbjct: 1299 PGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 265 bits (676), Expect = 1e-69
Identities = 320/1235 (25%), Positives = 520/1235 (42%), Gaps = 153/1235 (12%)
Query: 201 VDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERIN 260
+D F VHP +G+I + RL+ + ++ Y + + + ++ + + +N
Sbjct: 113 LDDFHVHPDTGIIRTARRLDRERRDHYSFVAATL-----------LGAVVQVEIRVNDVN 161
Query: 261 EHAPTIHV--------------------VTHVPFS-LEKEPTYAVVTVDDLDDGANGEIE 299
+H+P + V H P + L Y +V DL G
Sbjct: 162 DHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFF 221
Query: 300 SVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSAL 359
+ PL L L + +++D E + L ++A D G P++ L
Sbjct: 222 QLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAA-AHRLQIEAWDGGRPRRTGLL 280
Query: 360 KAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPI--------DVEYKL 411
D P+ FE++ Y ++ E + PG V V+ + + V +
Sbjct: 281 SVELRVLDENDNPPV-FEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQ 339
Query: 412 SPGE--------DAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLK-----AQV 458
PG DA YF + SG++ RPL+ + ++L V ++G + +V
Sbjct: 340 VPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRV 399
Query: 459 TISIEDANDHTPEFQQPLYD----AYVNESVPVGTSVLTVSASDKD---------KGE-- 503
+I++ D ND+ P A V+E G V VS SD D GE
Sbjct: 400 SIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELG 459
Query: 504 ----NGYITYSI----ASLNLLPFVINQFTGVISTTEE--LDFESSPEIYRFIVRASDWG 553
+G I+ S+ LLP GV E LD ES ++Y ++ A+D G
Sbjct: 460 VGLGDGSISLSLEGGEGDFALLP---GGPPGVFFLCVEGPLDRESR-DLYELLLVATDAG 515
Query: 554 SPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDEL----E 609
SP +E + +R+ ++ND PLF + + +S G + VSA D DE
Sbjct: 516 SP-PLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
Query: 610 LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINI 669
++Y ++ L+ + L+ + ++ +FA+ D S I
Sbjct: 575 WLRYTVVQ--------LSAPCNLGSLQSKMVHTAECGPSFAI-----------DSESGAI 615
Query: 670 SVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSF 729
S + + VAQ L E L A + ++D +N P F +
Sbjct: 616 STIRTLDREVQEAVELKVVAQDLGEPPL-SATCLVSITVDD-------VNDNEPIFWRQV 667
Query: 730 PSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDG----NTDSCFNIDMETGQLKV 785
+ + E PVG L++ A DADSG G + +++ DG F ID GQ+ V
Sbjct: 668 -YNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 726
Query: 786 LMPMDREHTD-LYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESS 844
+DRE Y L + D G S+ + +++ED NDN PVF +Y +I + +
Sbjct: 727 SQDIDRERDPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDET 784
Query: 845 GIGTEIIQVEARDKDLGSNGEVTYSVLTD--TQQFAINSSTGIVYVADQLDRESKANYSL 902
GTEII V A D+D G G V Y ++ + F I+S+TGI+Y+ L SL
Sbjct: 785 QPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSL 844
Query: 903 KIEARDKAESGQQLFSVVTLKVFLDDVNDCSPA-FIPSSYSVKVLEDLPVGTVIAWLETH 961
+ A+D + + VT+ +F + +PA F Y+ V ED+P + I ++
Sbjct: 845 MVSAQDGGGLTAVINADVTIHIFQTTL---APAEFERPKYTFLVYEDVPEDSPIGTVKAR 901
Query: 962 DPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS 1020
+P L + Y + + D G+F I G IR K LD+E Q LTV+A+ P
Sbjct: 902 EP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC 960
Query: 1021 LSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQY 1080
S+ V + V+DVN+N P F + + + + GT++ A D DSGR+G I+Y
Sbjct: 961 SSTE--VNITVMDVNDN--HPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRY 1016
Query: 1081 SIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVED 1140
SI G F+ID GV+ L LT+ A D+GV P + + + + +E
Sbjct: 1017 SIASPQP-GVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEK 1075
Query: 1141 VNDNAPLTSEPIYYPV-VMENSPKDVSVIQIQAE--DPDSSSNEKLTYRITSGNPQNFFA 1197
+ T E + Y V V E+ ++Q QA P +++ L Y + F
Sbjct: 1076 REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS-PLRYSLEPSVDSAMFG 1134
Query: 1198 INIKTGLITTTSRKLDREQQAEHFLEV--TVTDGGPSPKQSTIWVVVQVLDENDNKPQFP 1255
I TG I R+ D E + V + + G ST V+V+V DENDN P F
Sbjct: 1135 IRPYTGWI-YLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTT-VIVRVWDENDNSPTFL 1192
Query: 1256 EKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFF-IDPKTGMVS 1314
V +K+ E + I + A D D G N ++ Y ++ DGKFF ++P TG +
Sbjct: 1193 HDVLFLKVEESPVPQ--GVIGKITAIDMDSGKNGQLLYFLL---SDGKFFKMNPNTGELI 1247
Query: 1315 SRKQFTA--GSYDILTIKAVDNGRPQKSSTARLHI 1347
+ + +T+ D G P +++T +++
Sbjct: 1248 NWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYV 1282
Score = 254 bits (649), Expect = 1e-66
Identities = 333/1296 (25%), Positives = 539/1296 (41%), Gaps = 157/1296 (12%)
Query: 1157 VMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQN----FFAINIKTGLITTTSRKL 1212
V E P D V I+A P + E + ++ + + F ++ TG+I T +R+L
Sbjct: 73 VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRT-ARRL 131
Query: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRG 1272
DRE++ +H+ V T G + + V ++V D ND+ P+FP Q+ + E G
Sbjct: 132 DRERR-DHYSFVAATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSE--LSPPG 183
Query: 1273 EPIYRAFAFDRDEGPNAEISYSIVDGND-----DGKFF---------------------I 1306
A D D G + Y++V +D G FF +
Sbjct: 184 TAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPL 243
Query: 1307 DPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPF 1366
+P ++ R + L I+A D GRP+++ + + + + P+ F++
Sbjct: 244 EPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPV---FEQDE 300
Query: 1367 YNFTVME-------------SDRVTEIVGVV--SVQPANTPLWFDIVGGNFDSA-FDAEK 1410
Y V E +DR G V SV+ P G D+A F E+
Sbjct: 301 YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
Query: 1411 GVGTIVIAKPLDAEQRSIYNMSVEVTDG---TNVAVTQVFIKVLDNNDNGPE----FSQP 1463
G + + +PLD E ++ + + VE DG VA +V I VLD NDN P F
Sbjct: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTE 420
Query: 1464 NYDVTISEDVLPDTEILQIEATDRD---EKH-----KLSYTVHSSIDSISMRKFRID--- 1512
+SE P + ++ +D D EK +L + S+S+ D
Sbjct: 421 GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFAL 480
Query: 1513 -----PSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFT 1567
P L LD E++D + L ++ D P +++ V D ND P F+
Sbjct: 481 LPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFS 540
Query: 1568 NPLYEASVFESAALGSAVLQVTALDKDK--GENAELIYT-----------------IEAG 1608
Y+ASV E+AA G+ V+ V+A D D+ ++A L YT +
Sbjct: 541 QQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTA 600
Query: 1609 NTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSH 1668
G F I+ G I+ + D L + D G PP+SAT +V I+V +++
Sbjct: 601 ECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNE 660
Query: 1669 PKFIHKDYQAEVNENVDIGTSVILISAISQST-----LIYEVKDGDIN----GIFTINPY 1719
P F + Y A + E+ +G + ++A + + Y + DG ++ F I+P+
Sbjct: 661 PIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH 720
Query: 1720 SGVITTQKALDYER-TSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSL 1778
G I + +D ER ++Y L+++A + G+++ A V + + D NDN PVF S Y S+
Sbjct: 721 DGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSI 780
Query: 1779 S-EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIA 1837
S E P I+ L ATD DS + Y+++ FT+DS+TG I
Sbjct: 781 SDETQPGTEIINVL--------ATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTL 832
Query: 1838 NLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTY 1897
L H V +D G LTA +V I + P F + + ++
Sbjct: 833 PLSHLESTTLSLMVSAQDGGG--LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVP 890
Query: 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGSL-DHFLIDSNSGVLTIKN--NNLSKDHYMLI 1954
+ V A +P + P + Y + G L F I G + + ++ ++ +L
Sbjct: 891 EDSPIGTVKAREPLNSSEP-IFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLT 949
Query: 1955 VKVSDGK--FYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAV--GNR 2010
V+ G S++ V I V + D+ F ++ IS+ T + + A +
Sbjct: 950 VQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSG 1009
Query: 2011 LNEPLKYSILNP-GNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVV 2069
N ++YSI +P F I GV+ G E++EL L + A + H + A +V
Sbjct: 1010 RNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQREL-TLTLRAEDQGVHPQAALLV 1068
Query: 2070 VRVNIEDINDNSP--VFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPN---GEVTYVLQ 2124
+ V IE ++SP F L Y V P T + Q A GP + Y L+
Sbjct: 1069 LTVVIEK-REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLE 1125
Query: 2125 D--DYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILA---KDGGKPSLSTSVELPITIV 2179
D F I P +G + L+ F+ + S Y + A +DG ++ST+V + +
Sbjct: 1126 PSVDSAMFGIRPYTGWIYLRRQFDYE-STQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDE 1184
Query: 2180 NKAMPVFDKPFYTASVNEDIRMNTPILSINA----TSPEGQGIIYIIIDGDPFKQFNIDF 2235
N P F V E I I A + GQ + +++ DG K F ++
Sbjct: 1185 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFKMNP 1241
Query: 2236 DTGVLKVVSPLDYEVTSAYKLTIRASDALTGAR-AEVTVDLLVNDVNDNPPIFDQPTYNT 2294
+TG L LD E +++T+ +D + R A + V + V D+NDN P F Q
Sbjct: 1242 NTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 1301
Query: 2295 TLSEASLIGTPVLQVVSI----DADSENNKMVHYQI 2326
L L G PV +V+ D D NN V Y +
Sbjct: 1302 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 239 bits (610), Expect = 5e-62
Identities = 273/1071 (25%), Positives = 440/1071 (41%), Gaps = 113/1071 (10%)
Query: 1727 KALDYERTSSYQLIIQATN-----MAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSE- 1780
+ LD E ++++L I+A + G+ S V ++++DENDN PVF +Y ++ E
Sbjct: 252 RRLDREEAAAHRLQIEAWDGGRPRRTGLLS---VELRVLDENDNPPVFEQDEYRAAVRED 308
Query: 1781 AAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAK------------KFFTVDS 1828
A P + R +RATD D N + Y + +F V+
Sbjct: 309 AQPGAEVCR--------VRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEE 360
Query: 1829 STGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVF 1888
+G +R LD E A V RD G+ A V V+I V DVNDN P
Sbjct: 361 LSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVAT--VRVSIAVLDVNDNRPAIHVLFL 418
Query: 1889 ETILLLPTYVGVE----VLKVSATDPDS------EVPPELTYSLMEGSLDHFLIDSNSGV 1938
+ G V +VS +D D E EL L +GS+ L
Sbjct: 419 TEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDF 478
Query: 1939 LTIKN--------------NNLSKDHYMLIVKVSDG---KFYSTSMVTIMVKEAMDSGLH 1981
+ + S+D Y L++ +D + + + V + D
Sbjct: 479 ALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPL 538
Query: 1982 FTQSFYSTSISENNTNITKVAIVNA-----VGN----------RLNEPLKYSILNP---- 2022
F+Q Y S+SE T V V+A G+ +L+ P L
Sbjct: 539 FSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVH 598
Query: 2023 ----GNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDIN 2078
G F I S SG I T DRE QE EL V A + A +V + ++D+N
Sbjct: 599 TAECGPSFAIDSESGAISTIRT-LDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVN 657
Query: 2079 DNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFE------I 2132
DN P+F Y A + A G QVTA D D G G + Y L D + +E I
Sbjct: 658 DNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRI 717
Query: 2133 NPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYT 2192
+P+ G + + + + + Y + + AKDGG S V + + VN PVF+ Y
Sbjct: 718 DPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 777
Query: 2193 ASVNEDIRMNTPILSINATSPEG---QGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYE 2249
S++++ + T I+++ AT + + Y +I G+ F ID TG++ + PL +
Sbjct: 778 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHL 837
Query: 2250 VTSAYKLTIRASDALTGARAEVTVDLLVNDVNDN--PPIFDQPTYNTTLSEASLIGTPVL 2307
++ L + A D G A + D+ ++ P F++P Y + E +P+
Sbjct: 838 ESTTLSLMVSAQDG-GGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPI- 895
Query: 2308 QVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSI 2367
V +++ + Y+I F I G I T + LDHE L V++
Sbjct: 896 GTVKAREPLNSSEPIFYRISSGDLGGK--FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQ 953
Query: 2368 DSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFD 2427
P+ SS V+I + DVNDN P F + E +S+ P G + +A D DS
Sbjct: 954 LGSAPACSS-TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 1012
Query: 2428 RLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD-GLFTSTAQVHIR- 2485
+ YSI S F +D GV+ L+ + +L + D G+ A + +
Sbjct: 1013 LIRYSIASPQPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV 1071
Query: 2486 VLGANLYSPA--FSQSTYVAEVRENVAAGTKVIHVRATD-GDPGTYGQISYAIINDFAKD 2542
V+ +SP+ F Y EV E+++ T+++ +A G + Y++
Sbjct: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSA 1131
Query: 2543 RFLI-DSNGQVITTERLDRENPLEGDVSIFV-RALDGGGRTTFCTVRVIVVDENDNAPQF 2600
F I G + + D E+ + +F DG + TV V V DENDN+P F
Sbjct: 1132 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF 1191
Query: 2601 M-TVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGW 2659
+ V + + V +G ++ ++ AID D G N ++ Y L S+ +++P+ G
Sbjct: 1192 LHDVLFLKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLLSDGK-----FFKMNPNTGE 1245
Query: 2660 MVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQ 2710
++ ++ V D G P +++ + VY+ V P F Q
Sbjct: 1246 LINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 1296
Score = 182 bits (463), Expect = 5e-45
Identities = 206/790 (26%), Positives = 336/790 (42%), Gaps = 109/790 (13%)
Query: 117 LNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
L+RE+Q+ L V GE L A V+I V D+ND P+F Y+ TIAE P+
Sbjct: 621 LDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGH 680
Query: 176 SVAQVTATDADIGSNGEFYYYFKNKV------DLFSVHPTSGVISLSGRLNYD-EKNRYD 228
QVTA+DAD G G Y + F + P G I +S ++ + + YD
Sbjct: 681 CFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYD 740
Query: 229 LEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP-FSLEKEPTYAVVTV 287
L + A D G G+S+ A + V +E +N++ P + T+V S E +P ++ V
Sbjct: 741 LLVEAKDGG-------GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINV 793
Query: 288 --DDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGY---- 341
D D G G + + ++ G+ F I I + + P +
Sbjct: 794 LATDQDSGIYGTV-AYELIPGNVSSLF------------TIDSTTGIIYLTLPLSHLEST 840
Query: 342 --NLTLQAKDKGS-PQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIV 398
+L + A+D G +A ++I T P FE+ Y + E P + V
Sbjct: 841 TLSLMVSAQDGGGLTAVINADVTIHIFQTT--LAPAEFERPKYTFLVYEDVPEDSPIGTV 898
Query: 399 KLSPEPID----VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDL 454
K + EP++ + Y++S G+ F I+PR G I T +PL+ + V L V + G
Sbjct: 899 K-AREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA 957
Query: 455 KA----QVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYS 510
A +V I++ D ND+ P F + + ++++ P GT++ A D+D G NG I YS
Sbjct: 958 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 1017
Query: 511 IASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGN 570
IAS F I++ GV+ L E+ +RA D G ++ + V +
Sbjct: 1018 IASPQPGVFAIDRALGVLFLNGSLGAGEQREL-TLTLRAEDQG--VHPQAALLVLTVVIE 1074
Query: 571 VNDNSP--LFEKVACQGVISYDFPVGGHITAVSAIDIDELEL---VKYKIISGNELGFFY 625
++SP FE + Q +S + A + ++Y + + F
Sbjct: 1075 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFG 1134
Query: 626 LNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRE 685
+ P +G + L++ + NF R+ A E
Sbjct: 1135 IRPYTGWIYLRRQFDYESTQTYNF--RVFAW--------------------------IPE 1166
Query: 686 TRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANI 745
Q ++ ++++ + N P F + +P G I
Sbjct: 1167 DGFLQNVSTTVIVRV---------------WDENDNSPTFLHDVLFLKVEESPVPQGV-I 1210
Query: 746 LKIKAYDADSGFNGKVL-FTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIY 804
KI A D DSG NG++L F +SDG F ++ TG+L + +DREH + + + +
Sbjct: 1211 GKITAIDMDSGKNGQLLYFLLSDG---KFFKMNPNTGELINWVALDREHRGHHEMTVLVT 1267
Query: 805 DLGNPQKSSWRLLTINVEDANDNSPVFIQ----DSYSVNILESSGIGTEIIQVEARDKDL 860
D G+P +++ + ++V D NDN P F Q V +LE + + V A+D D
Sbjct: 1268 DRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDE 1327
Query: 861 GSNGEVTYSV 870
G+N EVTYSV
Sbjct: 1328 GNNAEVTYSV 1337
Score = 182 bits (461), Expect = 9e-45
Identities = 246/1036 (23%), Positives = 425/1036 (41%), Gaps = 139/1036 (13%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWT-KVNIQVLDMNDLRP----LFSPTTYSVTIAEST 171
L+RE Q + L+V+ G + E T +V+I VLD+ND RP LF ++E
Sbjct: 371 LDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGA 430
Query: 172 PLRTSVAQVTATDAD--------------IG-SNGEFYYYFKNKVDLFSVHP--TSGV-- 212
VA+V+ +DAD +G +G + F++ P GV
Sbjct: 431 RPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFF 490
Query: 213 ISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTI---HVV 269
+ + G L+ + ++ Y+L ++A D G+ +S+ L + + +N+ P H
Sbjct: 491 LCVEGPLDRESRDLYELLLVATDA-----GSPPLSTEETLLLRVADLNDQPPLFSQQHYK 545
Query: 270 THVPFSLEKEPTYAVVTVDDLDDGAN------------------GEIESVSIVAGDPLDQ 311
V + V+ D D+ + G ++S + +
Sbjct: 546 ASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPS 605
Query: 312 FFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDT 371
F + E ++ + +R+ + L + A+D G P + + D
Sbjct: 606 FAIDSESGAISTIRTLDREVQE------AVELKVVAQDLGEPPLSATCLVSITVDDVNDN 659
Query: 372 VPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID----VEYKLSPG----EDAVYFKIN 423
PI F ++VY+ +I+E +P G V S +EY L G E F+I+
Sbjct: 660 EPI-FWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRID 718
Query: 424 PRSGLIVTARPLNTVK-KEVYKLEVTNKEG---DLKAQVTISIEDANDHTPEFQQPLYDA 479
P G I ++ ++ + Y L V K+G +A V + +ED ND+ P F Y
Sbjct: 719 PHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVT 778
Query: 480 YVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVISTTEELDFES 538
+++ GT ++ V A+D+D G G + Y + N+ F I+ TG+I T L
Sbjct: 779 SISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLE 838
Query: 539 SPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHIT 598
S + +V A D G +VTI I FE+ ++ D P I
Sbjct: 839 STTL-SLMVSAQD-GGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIG 896
Query: 599 AVSAID-IDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATD 657
V A + ++ E + Y+I SG+ G F ++P G ++ +K L +
Sbjct: 897 TVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDH---------------- 940
Query: 658 GENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYS 717
+ + + + ++ S +C T V +
Sbjct: 941 -----ETQPVVVLTVQAQLGSAP-ACSSTEVN-----------------------ITVMD 971
Query: 718 INRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNID 777
+N P F ++ ++ + + P G + +A D DSG NG + ++I+ F ID
Sbjct: 972 VNDNHPAFLRT-SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGVFAID 1029
Query: 778 METGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSP--VFIQDS 835
G L + + L + D G +++ +LT+ +E ++SP F
Sbjct: 1030 RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE-KREHSPSWTFEHLV 1088
Query: 836 YSVNILESSGIGTEIIQVEARDKDLG---SNGEVTYSV--LTDTQQFAINSSTGIVYVAD 890
Y V + ES T+++Q +A LG + + YS+ D+ F I TG +Y+
Sbjct: 1089 YQVEVSESLSPMTQMLQTQAH--PLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRR 1146
Query: 891 QLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLP 950
Q D ES Y+ ++ A + Q S T+ V + D ND SP F+ +KV E
Sbjct: 1147 QFDYESTQTYNFRVFAWIPEDGFLQNVS-TTVIVRVWDENDNSPTFLHDVLFLKVEESPV 1205
Query: 951 VGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTV 1010
VI + D D G GQ+ Y L++D F+++ +G + LD E + + +TV
Sbjct: 1206 PQGVIGKITAIDMDSGKNGQLLYFLLSD-GKFFKMNPNTGELINWVALDREHRGHHEMTV 1264
Query: 1011 RAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDF----AVVGSVKENSRIGTSVLQVT 1066
D+G P ++++ V V V D+N+N P+FP + V E + V V
Sbjct: 1265 LVTDRGSPPRNATMA-VYVSVTDINDN--RPFFPQCLPGKELHVKVLEGQPVNMLVTTVF 1321
Query: 1067 ARDEDSGRDGEIQYSI 1082
A+D D G + E+ YS+
Sbjct: 1322 AKDPDEGNNAEVTYSV 1337
Score = 101 bits (251), Expect = 2e-20
Identities = 124/466 (26%), Positives = 199/466 (42%), Gaps = 45/466 (9%)
Query: 73 IDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGS 132
++ S I YRI SGD G F + IRT+ L+ E Q +L V+
Sbjct: 904 LNSSEPIFYRISSGDLGGKFSIHPRLGT------IRTRKP----LDHETQPVVVLTVQAQ 953
Query: 133 VRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGE 192
+ + T+VNI V+D+ND P F T+ + I+++TP T++ A D D G NG
Sbjct: 954 LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 1013
Query: 193 FYYYFKN-KVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAK 251
Y + + +F++ GV+ L+G L E+ L + A D+G+ + ++
Sbjct: 1014 IRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV-----HPQAALLV 1068
Query: 252 LYVHIERINEHAPTI---HVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDP 308
L V IE+ EH+P+ H+V V S P ++ G +
Sbjct: 1069 LTVVIEK-REHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 1127
Query: 309 LDQ--FFLAKEGKWLNEYKIKERKQIDWESFP-YGYNLTLQAKDKGSPQKCSALKAVYIG 365
+D F + W I R+Q D+ES Y + + + G Q S V +
Sbjct: 1128 VDSAMFGIRPYTGW-----IYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVW 1182
Query: 366 NPTRDTVPIRFEKEVYDVSISEFSPP----GVVVAIVKLSPEPIDVEYKLSPGEDAVYFK 421
+ D P F +V + + E P G + AI S + + Y L D +FK
Sbjct: 1183 DEN-DNSPT-FLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFK 1238
Query: 422 INPRSGLIVTARPLNTVKKEVYKLEVT-----NKEGDLKAQVTISIEDANDHTPEFQQPL 476
+NP +G ++ L+ + +++ V + + V +S+ D ND+ P F Q L
Sbjct: 1239 MNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCL 1298
Query: 477 ----YDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP 518
V E PV V TV A D D+G N +TYS++S +P
Sbjct: 1299 PGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMP 1344
Score = 62.0 bits (149), Expect = 1e-08
Identities = 49/181 (27%), Positives = 83/181 (45%), Gaps = 23/181 (12%)
Query: 142 TKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKV 201
T V ++V D ND P F + + ES + + ++TA D D G NG+ Y+ +
Sbjct: 1175 TTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG 1234
Query: 202 DLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINE 261
F ++P +G + L+ + + +++ +L DR G+ ++T +YV + IN+
Sbjct: 1235 KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDR-----GSPPRNATMAVYVSVTDIND 1289
Query: 262 HAP---------TIHVVTHVPFSLEKEPTYAVVT---VDDLDDGANGEIE-SVSIVAGDP 308
+ P +HV LE +P +VT D D+G N E+ SVS P
Sbjct: 1290 NRPFFPQCLPGKELHVKV-----LEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSARPMP 1344
Query: 309 L 309
L
Sbjct: 1345 L 1345
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 324 bits (830), Expect = 1e-87
Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
Query: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
Query: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 219 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 275
Query: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
++Y + T + AID D + + Y I+ G
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 387
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
E+ ++++ Y +S P + + L +
Sbjct: 388 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 421 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
Query: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 480 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 919 VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
+ T+ + + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
Query: 978 -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
D F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 712
Query: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
N + PY P V + N+ +G QV A D D+G +G++ YS+ + + L R +
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 766
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
+G I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y
Sbjct: 767 -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 825
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+V EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD
Sbjct: 826 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 882
Query: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267
E Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+
Sbjct: 883 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 938
Query: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322
+G PI +A D D P + + Y + D F ++ +G V +R
Sbjct: 939 -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
Query: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
I L + A D+G P SS+A + I + P IP E + V E +
Sbjct: 998 PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
VGV+S N + + IV GN + F G I + PLD E R+ Y + V+ D
Sbjct: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1113
Query: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
V + +V+I++ D N++ P F + Y +SED T +L+++ATD+D
Sbjct: 1114 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
Query: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
+ I I K F ++ TG++ TA + + ++ D
Sbjct: 1174 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
Query: 1548 NLARVIVNVEDANDHSPYFTN 1568
A V+V+V + D +N
Sbjct: 1234 GKADVLVSVVNQLDMQVIVSN 1254
Score = 311 bits (796), Expect = 1e-83
Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 249
Query: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
D I YS+ + P + N+ + +KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 370 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 485
Query: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 486 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909
Y + +Q + F I+ TG I+ ++ T+ +V A+D A +S
Sbjct: 546 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968
V + V N+ +P F Q +Y + E+ G V+ L DR+ + +Y I G+
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 656
Query: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026
P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+
Sbjct: 657 PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
PV D L + +N + +V A D D G NG + YSL N F +G +
Sbjct: 715 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 772
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144
T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y V EN
Sbjct: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199
+ +++A D D+G N V Y + + F++ +G + L + LD E Q++
Sbjct: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
S V A D G + TVT+ V D+ND PPVF +R Y V D GT + V+
Sbjct: 891 SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 949
Query: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314
A D R + Q F++ +G + L+ E F LVV A
Sbjct: 950 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 1009
Query: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373
D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A + N
Sbjct: 1010 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1064
Query: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426
I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA + +P+
Sbjct: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
Query: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ + I
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Query: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
+ +E E FV++ + G++++A++F + + V A D
Sbjct: 1185 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 310 bits (795), Expect = 2e-83
Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
Query: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 375 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245
G Q F IN TGLIT ++ + L V D P ++ S V ++VL
Sbjct: 549 LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
Query: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304
N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +G+ F
Sbjct: 607 PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 661
Query: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362
+ TG+++ K S D IL I A D GRP +STA ++I +P+ F
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 717
Query: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
D P+ N +V+E + + V + P N + + + GNF++ F G+I
Sbjct: 718 D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 773
Query: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V + E++
Sbjct: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
Query: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534
T ILQIEA D D +SY + S F + P TG L LD+EA
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
+I + F + A V V V+D ND+ P F+ +Y+ V A G+ + V A
Sbjct: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641
D D G A + ++ ++F++E V+ + + +EP TT+ F L +
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 1006
Query: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699
D G P MS++A V+I V + P+F ++Y+ V+E GT V +ISA +
Sbjct: 1007 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
Query: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752
+++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
Query: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810
A V I+I DEN++ PVF Y G +SE A + S L ++ATD D+ ++
Sbjct: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1178
Query: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
+ Y+++ K+ F V++ TG I+T + ++F F V D L+ ++ V
Sbjct: 1179 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1238
Query: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
+++++V N P + + + + +L YV ++
Sbjct: 1239 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1279
Score = 271 bits (694), Expect = 8e-72
Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 249
Query: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292
L V + ++ P VP + + P TY +VT + +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
N + S SI+ G P D E + E D F ++L ++
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 366
Query: 347 AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
A+ D G P A ++I + F Y I E +P G
Sbjct: 367 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 484 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565
ITY I F+IN+ TG+I+ ++ Y V+A+D P R S V
Sbjct: 544 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 602
Query: 566 IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624
I + N+ S P F ++ IS VG + + A D E + + Y I +G+ F
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 661
Query: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683
L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 662 NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 708
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P FD P +++V E+ A
Sbjct: 709 ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 734
Query: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
+ ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y L +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 791
Query: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N
Sbjct: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851
Query: 864 GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917
V+Y + + + FA++ TG + + LD E+ +A+ + +EA D G
Sbjct: 852 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 907
Query: 918 SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975
+ T+ V + D+ND P F Y V D GT I + E DP +VRY
Sbjct: 908 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 966
Query: 976 VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
V+D FE+++ SG + L+ E + L V A D G PV +SS + V++
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
V LH P F V E + GT V ++A + + I YSI G+
Sbjct: 1026 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1075
Query: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139
F I++ +GVI LD ET SY L V A VV +T +VYIE++
Sbjct: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
Query: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
D N++ P+ + Y V E++ SV++++A D D+ + + YR+ + F
Sbjct: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1195
Query: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+ TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1196 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 271 bits (694), Expect = 8e-72
Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)
Query: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
SD + YSIL G F M ++ ++L + + L +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580
T + +ND+ F + G + + +DRE + + + A DG
Sbjct: 433 IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 489
Query: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
+ V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N ITY +
Sbjct: 490 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 549
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698
A D + I+ G + + + V+A D P ++S+ VYI V
Sbjct: 550 VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755
LPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P+ +
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 660
Query: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
F + + TG + L K LDRE++ + + A+ + D T V+I V D+NDN PVF+
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 718
Query: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
+ + + QV+A D D G NGQV YSL + + F I SN G I
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 771
Query: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
T L+ E + VVA+D G ST ++++V DI+DN+PVF Y V+E
Sbjct: 772 YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
Query: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993
+ P G + + D D+ VSY I + FAL E + + R LD E
Sbjct: 831 NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 885
Query: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
E I FL + A D ++ T A V V V D+ND PV + Y ++ D
Sbjct: 886 PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
I V A+DAD +RY + + S F ++ +SG + T L+ E ++
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
L+ A D G S+ + IL P F+ + Y ATK + V +
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212
IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 1061 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
Query: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD G + +
Sbjct: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
Query: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329
Y LI ++GK F + TG I + + F V A D LS A V +
Sbjct: 1181 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Query: 3330 NLTDVND 3336
++ + D
Sbjct: 1241 SVVNQLD 1247
Score = 261 bits (668), Expect = 9e-69
Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 81 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 135
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 136 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
Query: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
+ D EI D +++ + N N+ + T + V
Sbjct: 196 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 255
Query: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
+DG L P+++ VL P T +P + I I +
Sbjct: 256 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 311 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 364
Query: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 485 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 540
Query: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012
N +++Y I G +G F + ++ + + ++ Y L + A D +
Sbjct: 541 NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069
V + V N+ SP Q+ Y+ + E + ++L + A D + S I Y++
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 654
Query: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128
G F L +G L LDRE Y L+ A+DG + +++++ DVNDN
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185
PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F I +S+G
Sbjct: 715 PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 769
Query: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF Y V V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304
E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+ LDYE
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 886
Query: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
+VEA D +ATV + + D+ND PP FS+ +Y +++ DA+ G +
Sbjct: 887 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 946
Query: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416
+ AED D P ++ + + + + F V+ G V + L+ E + + L+V
Sbjct: 947 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 1006
Query: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475
A D G P MSS+ATV I + + P FT Y + E GT + + +
Sbjct: 1007 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
Query: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527
+SI+SGNEE+ F + + G++ + YVL VQA +
Sbjct: 1066 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
Query: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585
P + + + + + +E+ H P ED + ++ ATD+D Y V+
Sbjct: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
Query: 3586 FAL----KSEQKSLFKVNSHDGKI 3605
+ L E K F V ++ G I
Sbjct: 1181 YRLIIPPIKEGKEGFVVETYTGLI 1204
Score = 259 bits (662), Expect = 4e-68
Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 128
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 129 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
Query: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 187 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 247 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
Query: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 305 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 364 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 482
Query: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 483 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 538
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN P +++S
Sbjct: 539 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400
++IE + PP + P F + Y+ + E+ RV ++ + + + + I G
Sbjct: 598 ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
Query: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458
+ F+ + G + + K LD E Y + + +DG + V I V D NDN P
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
F P + E+ + + Q++ATD D ++ VH S+ + + FRI S G
Sbjct: 716 VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 769
Query: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
+YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN Y V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
Query: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630
E+ G+ +LQ+ A D D G N Y I + + F + P G +++ + PD
Sbjct: 830 ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 887
Query: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690
F++ PP AT V + V ++ P F + Y+ V + GT +
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740
+ A + S + Y V D IF + SG + T+ L+ E T+ ++L+
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797
+ A + M+S+ATV I ++ + P F +Y +SE A ++V + + +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1063
Query: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857
N +VY IV + F +++ TG I LD+ET + V DS
Sbjct: 1064 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1112
Query: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911
L + + +V IE+ D N++PPVF + + + + VL+V ATD D
Sbjct: 1113 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
Query: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
+ + Y L+ EG + F++++ +G++ + +N+ + ++ V +D
Sbjct: 1173 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 256 bits (655), Expect = 3e-67
Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 373 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 402
Query: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Y L + + DS + ++ L KD +++ D
Sbjct: 403 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 439
Query: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
LH + Y++ + T IT+ T
Sbjct: 440 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 465
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 466 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + + Y +
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 581
Query: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
T+ A D P S+ T + N++ P F + Y+ ++E +R+ +L++ AT
Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
Query: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271
EG I Y I +GDP + FN+ TG+L + LD E T Y L I ASD +
Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
Query: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
TV+++V DVNDN P+FD P + + E + V QV + D D+ N VHY +
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
N + F I +S+G I TA L+ E+ + L V + D S + + I + D++D
Sbjct: 757 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
N PVF Y V E P G + ++A D D + Y I S + F + +G
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502
++L P +++ F A V + V N Y P FS+ Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556
V + GT + V A D DP ++ Y + + + F + + +G+VIT
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
L+ E + V A D G ++ TV+++V+ + P+F EYR +++
Sbjct: 993 NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1049
Query: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
+G +V + A N I YS+ S + D I+ G + G + T
Sbjct: 1050 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1102
Query: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
V+A + +P K + VYI + P F + Y ++ED + ++
Sbjct: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
Query: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
V ++ +S + E +G FV+E TG IK F F
Sbjct: 1163 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
+V AT K D++ +V +D++V+ N + E T D + E +P
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1280
Score = 253 bits (647), Expect = 2e-66
Identities = 285/1097 (25%), Positives = 479/1097 (43%), Gaps = 114/1097 (10%)
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698
P+ A A + I + +N P F YQ + E+ +G TS + I A+ +
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1699 STLIYEVKD-------GDINGIFTINPYSGV---ITTQKALDYERTSSYQLIIQATNMAG 1748
I + KD D +FT+ +G+ +T + +D E +Y I A +
Sbjct: 432 D--IEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 1749 MASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNR 1807
+ VNIQ++D NDN P F Y + ++ P +S+++ + A DAD
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGS 540
Query: 1808 NALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
N + Y+I+ A+ F ++ +TG I ++ + V D+ P S
Sbjct: 541 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
Query: 1868 EVNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS 1926
V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++ G
Sbjct: 600 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGD 656
Query: 1927 LDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLH 1981
F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D+
Sbjct: 657 PQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 1982 FTQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
F S E N + +V + +N + YS+ N N F+I S + T
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--T 773
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+ +
Sbjct: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
Query: 2099 PGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIE 2153
GT I Q+ A D D G N + F ++P +G + L EAF ++I
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
Query: 2154 YGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP 2213
+ V G P +V + + +N PVF K Y V D TPI ++ A
Sbjct: 894 FLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 953
Query: 2214 EGQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDAL 2264
+ G + Y + D P F ++ D+G + L+ E T+ +KL + A D
Sbjct: 954 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 1013
Query: 2265 TGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHY 2324
+ TV +LV + P + +SE + GT +V + + + N+ + Y
Sbjct: 1014 PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVY 1069
Query: 2325 QIVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSE 2377
IV N D F I++ +G+I LD+E VQ +L+V + PS S+
Sbjct: 1070 SIVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
Query: 2378 VLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL--- 2434
V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y ++
Sbjct: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
Query: 2435 SGNDRTSFLMDSKSGVI 2451
+ F++++ +G+I
Sbjct: 1188 IKEGKEGFVVETYTGLI 1204
Score = 238 bits (607), Expect = 1e-61
Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)
Query: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 393
Query: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 446
Query: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 503
Query: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 504 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 560
Query: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
+G+IT A ++ +Y LTV A D S VYIEV N+ +P +
Sbjct: 561 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 620
Query: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++ T + L
Sbjct: 621 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 676
Query: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271
DRE + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 677 DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330
+ + A D D G N ++ YS+ GN + F I + ++ K Y L +
Sbjct: 736 ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
Query: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388
A D + ST L I+ + SP+ F N +TV+ + + ++ ++
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 843
Query: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438
+ L + I F G + + + LD E Q + VE D G
Sbjct: 844 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
Query: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495
T +A V +K D ND P FS+ Y ++ D + T I + A D D +
Sbjct: 904 TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
Query: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
V +D + F ++ +G + T L+ E L ++ D P + A
Sbjct: 962 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 1021
Query: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610
V + V + P FT Y V E A G+ V ++A N ++Y+I +GN
Sbjct: 1022 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1076
Query: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663
+ F I + G+I + D T +VL ++ + + P S TA V I +
Sbjct: 1077 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713
+N P F K Y V+E+ + TSV+ + A + T +I +K+G
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1194
Query: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1195 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 186 bits (473), Expect = 4e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 524 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 575
Query: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 576 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 635
Query: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 636 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
Query: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 696 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
Query: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 751 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 806
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 807 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 866
Query: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
L+P +G L L +SL + + + A D P ++V+
Sbjct: 867 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 915
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P F K + V D G
Sbjct: 916 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 943
Query: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1062
Query: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 1063 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1115
Query: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
Query: 1017 RPVSLSSVSFVEVEVVDVN 1035
V +S V+ ++++V+ N
Sbjct: 1236 ADVLVSVVNQLDMQVIVSN 1254
Score = 174 bits (441), Expect = 2e-42
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
Query: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 587
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
N + + +Y+ + N +P + + V ++
Sbjct: 588 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 697
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 698 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 757
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 758 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 874
Query: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 875 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 984
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 985 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1026
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L G + P F + V E G + I A + N
Sbjct: 1027 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1066
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
Query: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Query: 929 VNDCSPAFIPSSYSVKVLEDL 949
+ +P + K +EDL
Sbjct: 1247 DMQVIVSNVPPTLVEKKIEDL 1267
Score = 168 bits (426), Expect = 1e-40
Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 220 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 279
Query: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
TY I E TP + VT A D D G Y + F
Sbjct: 280 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 339
Query: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 340 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 392
Query: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 393 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 449
Query: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 450 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 501
Query: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 502 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 557
Query: 422 INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473
IN +GLI A + + Y L V + A+ T+ IE N P F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532
Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG+++ +
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 674
Query: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 675 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ V A D D + GN F + + + K N +++ + L
Sbjct: 732 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 788
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ ATDG +H + S+ + LA K+L
Sbjct: 789 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 810
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 811 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 863
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 864 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 923
Query: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 924 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 982
Query: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 983 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1039
Query: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1095
Query: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 1096 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1153
Query: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1154 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1213
Query: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1214 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1270
Score = 145 bits (367), Expect = 7e-34
Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
Query: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 426 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 484 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536
G ++ IL G + + + G++ A + Y L VQA D+ P + ++
Sbjct: 542 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594
+ + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++ + +
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 659
Query: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
+F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 660 VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 694
Score = 102 bits (253), Expect = 1e-20
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 505 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 558
Query: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 559 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 670
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 671 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
Query: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 780
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 781 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 833
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 894 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 951
Query: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 952 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 1010
Query: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 1011 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1067
Query: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1116
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
+ +V SKS N +++ N P F K F
Sbjct: 1117 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1150
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 1151 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1207
Query: 787 M 787
M
Sbjct: 1208 M 1208
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 1058 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1115
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1230
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1231 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1269
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 324 bits (830), Expect = 1e-87
Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 77 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 136
Query: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 137 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 196
Query: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 197 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 253
Query: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
++Y + T + AID D + + Y I+ G
Sbjct: 254 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313
Query: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 314 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 365
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
E+ ++++ Y +S P + + L +
Sbjct: 366 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
Query: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 399 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 457
Query: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 458 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515
Query: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S
Sbjct: 516 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 919 VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
+ T+ + + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N
Sbjct: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 632
Query: 978 -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
D F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+
Sbjct: 633 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 690
Query: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
N + PY P V + N+ +G QV A D D+G +G++ YS+ + + L R +
Sbjct: 691 NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 744
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
+G I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y
Sbjct: 745 -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 803
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+V EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD
Sbjct: 804 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 860
Query: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267
E Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+
Sbjct: 861 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 916
Query: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322
+G PI +A D D P + + Y + D F ++ +G V +R
Sbjct: 917 -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 975
Query: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
I L + A D+G P SS+A + I + P IP E + V E +
Sbjct: 976 PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1032
Query: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
VGV+S N + + IV GN + F G I + PLD E R+ Y + V+ D
Sbjct: 1033 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1091
Query: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
V + +V+I++ D N++ P F + Y +SED T +L+++ATD+D
Sbjct: 1092 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1151
Query: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
+ I I K F ++ TG++ TA + + ++ D
Sbjct: 1152 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1211
Query: 1548 NLARVIVNVEDANDHSPYFTN 1568
A V+V+V + D +N
Sbjct: 1212 GKADVLVSVVNQLDMQVIVSN 1232
Score = 311 bits (796), Expect = 1e-83
Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 227
Query: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 228 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 287
Query: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
D I YS+ + P + N+ + +KA
Sbjct: 288 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 347
Query: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 348 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
Query: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 463
Query: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 464 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 523
Query: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909
Y + +Q + F I+ TG I+ ++ T+ +V A+D A +S
Sbjct: 524 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968
V + V N+ +P F Q +Y + E+ G V+ L DR+ + +Y I G+
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 634
Query: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026
P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+
Sbjct: 635 PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 692
Query: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
PV D L + +N + +V A D D G NG + YSL N F +G +
Sbjct: 693 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 750
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144
T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y V EN
Sbjct: 751 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 810
Query: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199
+ +++A D D+G N V Y + + F++ +G + L + LD E Q++
Sbjct: 811 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 868
Query: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
S V A D G + TVT+ V D+ND PPVF +R Y V D GT + V+
Sbjct: 869 SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 927
Query: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314
A D R + Q F++ +G + L+ E F LVV A
Sbjct: 928 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 987
Query: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373
D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A + N
Sbjct: 988 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1042
Query: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426
I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA + +P+
Sbjct: 1043 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1102
Query: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ + I
Sbjct: 1103 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1162
Query: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
+ +E E FV++ + G++++A++F + + V A D
Sbjct: 1163 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Score = 310 bits (795), Expect = 2e-83
Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
Query: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
Query: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
Query: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 352
Query: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 353 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
Query: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 409 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 466
Query: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 526
Query: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245
G Q F IN TGLIT ++ + L V D P ++ S V ++VL
Sbjct: 527 LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 584
Query: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304
N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +G+ F
Sbjct: 585 PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 639
Query: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362
+ TG+++ K S D IL I A D GRP +STA ++I +P+ F
Sbjct: 640 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 695
Query: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
D P+ N +V+E + + V + P N + + + GNF++ F G+I
Sbjct: 696 D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 751
Query: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V + E++
Sbjct: 752 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 811
Query: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534
T ILQIEA D D +SY + S F + P TG L LD+EA
Sbjct: 812 AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 868
Query: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
+I + F + A V V V+D ND+ P F+ +Y+ V A G+ + V A
Sbjct: 869 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
Query: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641
D D G A + ++ ++F++E V+ + + +EP TT+ F L +
Sbjct: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 984
Query: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699
D G P MS++A V+I V + P+F ++Y+ V+E GT V +ISA +
Sbjct: 985 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1043
Query: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752
+++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1044 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1103
Query: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810
A V I+I DEN++ PVF Y G +SE A + S L ++ATD D+ ++
Sbjct: 1104 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1156
Query: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
+ Y+++ K+ F V++ TG I+T + ++F F V D L+ ++ V
Sbjct: 1157 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1216
Query: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
+++++V N P + + + + +L YV ++
Sbjct: 1217 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1257
Score = 271 bits (694), Expect = 8e-72
Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 227
Query: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292
L V + ++ P VP + + P TY +VT + +D
Sbjct: 228 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 287
Query: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
N + S SI+ G P D E + E D F ++L ++
Sbjct: 288 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 344
Query: 347 AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
A+ D G P A ++I + F Y I E +P G
Sbjct: 345 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 402
Query: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 403 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 461
Query: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 462 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 521
Query: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565
ITY I F+IN+ TG+I+ ++ Y V+A+D P R S V
Sbjct: 522 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 580
Query: 566 IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624
I + N+ S P F ++ IS VG + + A D E + + Y I +G+ F
Sbjct: 581 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 639
Query: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683
L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 640 NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 686
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P FD P +++V E+ A
Sbjct: 687 ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 712
Query: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
+ ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y L +
Sbjct: 713 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 769
Query: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N
Sbjct: 770 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 829
Query: 864 GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917
V+Y + + + FA++ TG + + LD E+ +A+ + +EA D G
Sbjct: 830 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 885
Query: 918 SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975
+ T+ V + D+ND P F Y V D GT I + E DP +VRY
Sbjct: 886 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 944
Query: 976 VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
V+D FE+++ SG + L+ E + L V A D G PV +SS + V++
Sbjct: 945 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1003
Query: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
V LH P F V E + GT V ++A + + I YSI G+
Sbjct: 1004 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1053
Query: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139
F I++ +GVI LD ET SY L V A VV +T +VYIE++
Sbjct: 1054 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1113
Query: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
D N++ P+ + Y V E++ SV++++A D D+ + + YR+ + F
Sbjct: 1114 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1173
Query: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+ TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1174 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 271 bits (694), Expect = 8e-72
Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)
Query: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
SD + YSIL G F M ++ ++L + + L +
Sbjct: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
Query: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 351 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 410
Query: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580
T + +ND+ F + G + + +DRE + + + A DG
Sbjct: 411 IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 467
Query: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
+ V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N ITY +
Sbjct: 468 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 527
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698
A D + I+ G + + + V+A D P ++S+ VYI V
Sbjct: 528 VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
Query: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755
LPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P+ +
Sbjct: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 638
Query: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
F + + TG + L K LDRE++ + + A+ + D T V+I V D+NDN PVF+
Sbjct: 639 FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 696
Query: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
+ + + QV+A D D G NGQV YSL + + F I SN G I
Sbjct: 697 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 749
Query: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
T L+ E + VVA+D G ST ++++V DI+DN+PVF Y V+E
Sbjct: 750 YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 808
Query: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993
+ P G + + D D+ VSY I + FAL E + + R LD E
Sbjct: 809 NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 863
Query: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
E I FL + A D ++ T A V V V D+ND PV + Y ++ D
Sbjct: 864 PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 921
Query: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
I V A+DAD +RY + + S F ++ +SG + T L+ E ++
Sbjct: 922 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 981
Query: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
L+ A D G S+ + IL P F+ + Y ATK + V +
Sbjct: 982 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1038
Query: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212
IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 1039 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1098
Query: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD G + +
Sbjct: 1099 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1158
Query: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329
Y LI ++GK F + TG I + + F V A D LS A V +
Sbjct: 1159 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1218
Query: 3330 NLTDVND 3336
++ + D
Sbjct: 1219 SVVNQLD 1225
Score = 261 bits (668), Expect = 9e-69
Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 59 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 113
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 114 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 173
Query: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
+ D EI D +++ + N N+ + T + V
Sbjct: 174 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 233
Query: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
+DG L P+++ VL P T +P + I I +
Sbjct: 234 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 289 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 342
Query: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 343 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 402
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 403 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 462
Query: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 463 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 518
Query: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012
N +++Y I G +G F + ++ + + ++ Y L + A D +
Sbjct: 519 NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069
V + V N+ SP Q+ Y+ + E + ++L + A D + S I Y++
Sbjct: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 632
Query: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128
G F L +G L LDRE Y L+ A+DG + +++++ DVNDN
Sbjct: 633 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 692
Query: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185
PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F I +S+G
Sbjct: 693 PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 747
Query: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF Y V V
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 806
Query: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304
E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+ LDYE
Sbjct: 807 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 864
Query: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
+VEA D +ATV + + D+ND PP FS+ +Y +++ DA+ G +
Sbjct: 865 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 924
Query: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416
+ AED D P ++ + + + + F V+ G V + L+ E + + L+V
Sbjct: 925 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 984
Query: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475
A D G P MSS+ATV I + + P FT Y + E GT + + +
Sbjct: 985 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1043
Query: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527
+SI+SGNEE+ F + + G++ + YVL VQA +
Sbjct: 1044 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1098
Query: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585
P + + + + + +E+ H P ED + ++ ATD+D Y V+
Sbjct: 1099 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1158
Query: 3586 FAL----KSEQKSLFKVNSHDGKI 3605
+ L E K F V ++ G I
Sbjct: 1159 YRLIIPPIKEGKEGFVVETYTGLI 1182
Score = 259 bits (662), Expect = 4e-68
Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 52 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 106
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 107 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 164
Query: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 165 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 224
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 225 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 282
Query: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 283 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 342 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 401
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 402 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 460
Query: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 461 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 516
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN P +++S
Sbjct: 517 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400
++IE + PP + P F + Y+ + E+ RV ++ + + + + I G
Sbjct: 576 ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 633
Query: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458
+ F+ + G + + K LD E Y + + +DG + V I V D NDN P
Sbjct: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 693
Query: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
F P + E+ + + Q++ATD D ++ VH S+ + + FRI S G
Sbjct: 694 VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 747
Query: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
+YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN Y V
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 807
Query: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630
E+ G+ +LQ+ A D D G N Y I + + F + P G +++ + PD
Sbjct: 808 ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 865
Query: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690
F++ PP AT V + V ++ P F + Y+ V + GT +
Sbjct: 866 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
Query: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740
+ A + S + Y V D IF + SG + T+ L+ E T+ ++L+
Sbjct: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 983
Query: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797
+ A + M+S+ATV I ++ + P F +Y +SE A ++V + + +
Sbjct: 984 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1041
Query: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857
N +VY IV + F +++ TG I LD+ET + V DS
Sbjct: 1042 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1090
Query: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911
L + + +V IE+ D N++PPVF + + + + VL+V ATD D
Sbjct: 1091 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1150
Query: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
+ + Y L+ EG + F++++ +G++ + +N+ + ++ V +D
Sbjct: 1151 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Score = 256 bits (655), Expect = 3e-67
Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
Query: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 351 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 380
Query: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Y L + + DS + ++ L KD +++ D
Sbjct: 381 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 417
Query: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
LH + Y++ + T IT+ T
Sbjct: 418 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 443
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 444 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 500
Query: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + + Y +
Sbjct: 501 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 559
Query: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
T+ A D P S+ T + N++ P F + Y+ ++E +R+ +L++ AT
Sbjct: 560 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 619
Query: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271
EG I Y I +GDP + FN+ TG+L + LD E T Y L I ASD +
Sbjct: 620 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 679
Query: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
TV+++V DVNDN P+FD P + + E + V QV + D D+ N VHY +
Sbjct: 680 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 734
Query: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
N + F I +S+G I TA L+ E+ + L V + D S + + I + D++D
Sbjct: 735 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
Query: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
N PVF Y V E P G + ++A D D + Y I S + F + +G
Sbjct: 793 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 850
Query: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502
++L P +++ F A V + V N Y P FS+ Y
Sbjct: 851 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 910
Query: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556
V + GT + V A D DP ++ Y + + + F + + +G+VIT
Sbjct: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
Query: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
L+ E + V A D G ++ TV+++V+ + P+F EYR +++
Sbjct: 971 NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1027
Query: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
+G +V + A N I YS+ S + D I+ G + G + T
Sbjct: 1028 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1080
Query: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
V+A + +P K + VYI + P F + Y ++ED + ++
Sbjct: 1081 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1140
Query: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
V ++ +S + E +G FV+E TG IK F F
Sbjct: 1141 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1198
Query: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
+V AT K D++ +V +D++V+ N + E T D + E +P
Sbjct: 1199 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1258
Score = 253 bits (647), Expect = 2e-66
Identities = 285/1097 (25%), Positives = 479/1097 (43%), Gaps = 114/1097 (10%)
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698
P+ A A + I + +N P F YQ + E+ +G TS + I A+ +
Sbjct: 350 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
Query: 1699 STLIYEVKD-------GDINGIFTINPYSGV---ITTQKALDYERTSSYQLIIQATNMAG 1748
I + KD D +FT+ +G+ +T + +D E +Y I A +
Sbjct: 410 D--IEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 466
Query: 1749 MASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNR 1807
+ VNIQ++D NDN P F Y + ++ P +S+++ + A DAD
Sbjct: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGS 518
Query: 1808 NALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
N + Y+I+ A+ F ++ +TG I ++ + V D+ P S
Sbjct: 519 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 577
Query: 1868 EVNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS 1926
V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++ G
Sbjct: 578 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGD 634
Query: 1927 LDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLH 1981
F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D+
Sbjct: 635 PQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 694
Query: 1982 FTQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
F S E N + +V + +N + YS+ N N F+I S + T
Sbjct: 695 FDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--T 751
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+ +
Sbjct: 752 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 811
Query: 2099 PGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIE 2153
GT I Q+ A D D G N + F ++P +G + L EAF ++I
Sbjct: 812 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 871
Query: 2154 YGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP 2213
+ V G P +V + + +N PVF K Y V D TPI ++ A
Sbjct: 872 FLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 931
Query: 2214 EGQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDAL 2264
+ G + Y + D P F ++ D+G + L+ E T+ +KL + A D
Sbjct: 932 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 991
Query: 2265 TGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHY 2324
+ TV +LV + P + +SE + GT +V + + + N+ + Y
Sbjct: 992 PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVY 1047
Query: 2325 QIVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSE 2377
IV N D F I++ +G+I LD+E VQ +L+V + PS S+
Sbjct: 1048 SIVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1105
Query: 2378 VLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL--- 2434
V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y ++
Sbjct: 1106 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1165
Query: 2435 SGNDRTSFLMDSKSGVI 2451
+ F++++ +G+I
Sbjct: 1166 IKEGKEGFVVETYTGLI 1182
Score = 238 bits (607), Expect = 1e-61
Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)
Query: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 134 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 193
Query: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 194 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 253
Query: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 254 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313
Query: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 314 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 371
Query: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 372 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 424
Query: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 425 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 481
Query: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 482 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 538
Query: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
+G+IT A ++ +Y LTV A D S VYIEV N+ +P +
Sbjct: 539 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 598
Query: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++ T + L
Sbjct: 599 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 654
Query: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271
DRE + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 655 DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 713
Query: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330
+ + A D D G N ++ YS+ GN + F I + ++ K Y L +
Sbjct: 714 ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 768
Query: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388
A D + ST L I+ + SP+ F N +TV+ + + ++ ++
Sbjct: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 821
Query: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438
+ L + I F G + + + LD E Q + VE D G
Sbjct: 822 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 881
Query: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495
T +A V +K D ND P FS+ Y ++ D + T I + A D D +
Sbjct: 882 TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 939
Query: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
V +D + F ++ +G + T L+ E L ++ D P + A
Sbjct: 940 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 999
Query: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610
V + V + P FT Y V E A G+ V ++A N ++Y+I +GN
Sbjct: 1000 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1054
Query: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663
+ F I + G+I + D T +VL ++ + + P S TA V I +
Sbjct: 1055 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1114
Query: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713
+N P F K Y V+E+ + TSV+ + A + T +I +K+G
Sbjct: 1115 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1172
Query: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1173 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 186 bits (473), Expect = 4e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 331 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 390
Query: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 391 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 450
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 451 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 501
Query: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 502 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 553
Query: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 554 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 613
Query: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 614 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 673
Query: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 674 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 728
Query: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 729 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 784
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 785 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 844
Query: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
L+P +G L L +SL + + + A D P ++V+
Sbjct: 845 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 893
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P F K + V D G
Sbjct: 894 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 921
Query: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 922 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 981
Query: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 982 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1040
Query: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 1041 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1093
Query: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
Query: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1213
Query: 1017 RPVSLSSVSFVEVEVVDVN 1035
V +S V+ ++++V+ N
Sbjct: 1214 ADVLVSVVNQLDMQVIVSN 1232
Score = 174 bits (441), Expect = 2e-42
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 447 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 505
Query: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 506 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 565
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
N + + +Y+ + N +P + + V ++
Sbjct: 566 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622
Query: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 623 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 675
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 676 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 735
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 736 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 794
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 795 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 852
Query: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 853 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 910
Query: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 962
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 963 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1004
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L G + P F + V E G + I A + N
Sbjct: 1005 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1044
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 1045 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1104
Query: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 1105 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1164
Query: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 1165 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
Query: 929 VNDCSPAFIPSSYSVKVLEDL 949
+ +P + K +EDL
Sbjct: 1225 DMQVIVSNVPPTLVEKKIEDL 1245
Score = 168 bits (426), Expect = 1e-40
Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 198 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 257
Query: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
TY I E TP + VT A D D G Y + F
Sbjct: 258 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 317
Query: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 318 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 370
Query: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 371 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 427
Query: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 428 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 479
Query: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 480 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 535
Query: 422 INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473
IN +GLI A + + Y L V + A+ T+ IE N P F
Sbjct: 536 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595
Query: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532
Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG+++ +
Sbjct: 596 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 652
Query: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 653 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 709
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ V A D D + GN F + + + K N +++ + L
Sbjct: 710 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 766
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ ATDG +H + S+ + LA K+L
Sbjct: 767 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 788
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 789 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 841
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 842 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 901
Query: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 902 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 960
Query: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 961 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1017
Query: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 1018 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1073
Query: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 1074 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1131
Query: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1132 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1191
Query: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1192 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1248
Score = 145 bits (367), Expect = 7e-34
Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 104 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 163
Query: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 164 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223
Query: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 224 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 283
Query: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 284 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 343
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 344 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 403
Query: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 404 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 461
Query: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 462 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 519
Query: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536
G ++ IL G + + + G++ A + Y L VQA D+ P + ++
Sbjct: 520 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594
+ + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++ + +
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 637
Query: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
+F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 638 VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 672
Score = 102 bits (253), Expect = 1e-20
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 483 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 536
Query: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 537 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 592
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 593 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 648
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 649 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 702
Query: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 703 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 758
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 759 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 811
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 812 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 871
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 872 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 929
Query: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 930 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 988
Query: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 989 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1045
Query: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 1046 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1094
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
+ +V SKS N +++ N P F K F
Sbjct: 1095 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1128
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 1129 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1185
Query: 787 M 787
M
Sbjct: 1186 M 1186
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 1036 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1093
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1208
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1209 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1247
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 324 bits (830), Expect = 1e-87
Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
Query: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
Query: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 219 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 275
Query: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
++Y + T + AID D + + Y I+ G
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 387
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
E+ ++++ Y +S P + + L +
Sbjct: 388 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 421 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
Query: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 480 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 919 VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
+ T+ + + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
Query: 978 -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
D F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 712
Query: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
N + PY P V + N+ +G QV A D D+G +G++ YS+ + + L R +
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 766
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
+G I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y
Sbjct: 767 -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 825
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+V EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD
Sbjct: 826 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 882
Query: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267
E Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+
Sbjct: 883 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 938
Query: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322
+G PI +A D D P + + Y + D F ++ +G V +R
Sbjct: 939 -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
Query: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
I L + A D+G P SS+A + I + P IP E + V E +
Sbjct: 998 PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
VGV+S N + + IV GN + F G I + PLD E R+ Y + V+ D
Sbjct: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1113
Query: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
V + +V+I++ D N++ P F + Y +SED T +L+++ATD+D
Sbjct: 1114 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
Query: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
+ I I K F ++ TG++ TA + + ++ D
Sbjct: 1174 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
Query: 1548 NLARVIVNVEDANDHSPYFTN 1568
A V+V+V + D +N
Sbjct: 1234 GKADVLVSVVNQLDMQVIVSN 1254
Score = 311 bits (796), Expect = 1e-83
Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 249
Query: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
D I YS+ + P + N+ + +KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 370 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 485
Query: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 486 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909
Y + +Q + F I+ TG I+ ++ T+ +V A+D A +S
Sbjct: 546 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968
V + V N+ +P F Q +Y + E+ G V+ L DR+ + +Y I G+
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 656
Query: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026
P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+
Sbjct: 657 PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
PV D L + +N + +V A D D G NG + YSL N F +G +
Sbjct: 715 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 772
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144
T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y V EN
Sbjct: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199
+ +++A D D+G N V Y + + F++ +G + L + LD E Q++
Sbjct: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
S V A D G + TVT+ V D+ND PPVF +R Y V D GT + V+
Sbjct: 891 SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 949
Query: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314
A D R + Q F++ +G + L+ E F LVV A
Sbjct: 950 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 1009
Query: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373
D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A + N
Sbjct: 1010 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1064
Query: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426
I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA + +P+
Sbjct: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
Query: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ + I
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Query: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
+ +E E FV++ + G++++A++F + + V A D
Sbjct: 1185 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 310 bits (795), Expect = 2e-83
Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
Query: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 375 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245
G Q F IN TGLIT ++ + L V D P ++ S V ++VL
Sbjct: 549 LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
Query: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304
N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +G+ F
Sbjct: 607 PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 661
Query: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362
+ TG+++ K S D IL I A D GRP +STA ++I +P+ F
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 717
Query: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
D P+ N +V+E + + V + P N + + + GNF++ F G+I
Sbjct: 718 D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 773
Query: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V + E++
Sbjct: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
Query: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534
T ILQIEA D D +SY + S F + P TG L LD+EA
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
+I + F + A V V V+D ND+ P F+ +Y+ V A G+ + V A
Sbjct: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641
D D G A + ++ ++F++E V+ + + +EP TT+ F L +
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 1006
Query: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699
D G P MS++A V+I V + P+F ++Y+ V+E GT V +ISA +
Sbjct: 1007 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
Query: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752
+++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
Query: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810
A V I+I DEN++ PVF Y G +SE A + S L ++ATD D+ ++
Sbjct: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1178
Query: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
+ Y+++ K+ F V++ TG I+T + ++F F V D L+ ++ V
Sbjct: 1179 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1238
Query: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
+++++V N P + + + + +L YV ++
Sbjct: 1239 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1279
Score = 271 bits (694), Expect = 8e-72
Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 249
Query: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292
L V + ++ P VP + + P TY +VT + +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
N + S SI+ G P D E + E D F ++L ++
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 366
Query: 347 AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
A+ D G P A ++I + F Y I E +P G
Sbjct: 367 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 484 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565
ITY I F+IN+ TG+I+ ++ Y V+A+D P R S V
Sbjct: 544 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 602
Query: 566 IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624
I + N+ S P F ++ IS VG + + A D E + + Y I +G+ F
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 661
Query: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683
L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 662 NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 708
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P FD P +++V E+ A
Sbjct: 709 ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 734
Query: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
+ ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y L +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 791
Query: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N
Sbjct: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851
Query: 864 GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917
V+Y + + + FA++ TG + + LD E+ +A+ + +EA D G
Sbjct: 852 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 907
Query: 918 SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975
+ T+ V + D+ND P F Y V D GT I + E DP +VRY
Sbjct: 908 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 966
Query: 976 VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
V+D FE+++ SG + L+ E + L V A D G PV +SS + V++
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
V LH P F V E + GT V ++A + + I YSI G+
Sbjct: 1026 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1075
Query: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139
F I++ +GVI LD ET SY L V A VV +T +VYIE++
Sbjct: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
Query: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
D N++ P+ + Y V E++ SV++++A D D+ + + YR+ + F
Sbjct: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1195
Query: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+ TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1196 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 271 bits (694), Expect = 8e-72
Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)
Query: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
SD + YSIL G F M ++ ++L + + L +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580
T + +ND+ F + G + + +DRE + + + A DG
Sbjct: 433 IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 489
Query: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
+ V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N ITY +
Sbjct: 490 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 549
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698
A D + I+ G + + + V+A D P ++S+ VYI V
Sbjct: 550 VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755
LPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P+ +
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 660
Query: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
F + + TG + L K LDRE++ + + A+ + D T V+I V D+NDN PVF+
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 718
Query: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
+ + + QV+A D D G NGQV YSL + + F I SN G I
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 771
Query: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
T L+ E + VVA+D G ST ++++V DI+DN+PVF Y V+E
Sbjct: 772 YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
Query: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993
+ P G + + D D+ VSY I + FAL E + + R LD E
Sbjct: 831 NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 885
Query: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
E I FL + A D ++ T A V V V D+ND PV + Y ++ D
Sbjct: 886 PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
I V A+DAD +RY + + S F ++ +SG + T L+ E ++
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
L+ A D G S+ + IL P F+ + Y ATK + V +
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212
IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 1061 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
Query: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD G + +
Sbjct: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
Query: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329
Y LI ++GK F + TG I + + F V A D LS A V +
Sbjct: 1181 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Query: 3330 NLTDVND 3336
++ + D
Sbjct: 1241 SVVNQLD 1247
Score = 261 bits (668), Expect = 9e-69
Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 81 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 135
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 136 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
Query: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
+ D EI D +++ + N N+ + T + V
Sbjct: 196 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 255
Query: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
+DG L P+++ VL P T +P + I I +
Sbjct: 256 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 311 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 364
Query: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 485 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 540
Query: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012
N +++Y I G +G F + ++ + + ++ Y L + A D +
Sbjct: 541 NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069
V + V N+ SP Q+ Y+ + E + ++L + A D + S I Y++
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 654
Query: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128
G F L +G L LDRE Y L+ A+DG + +++++ DVNDN
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185
PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F I +S+G
Sbjct: 715 PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 769
Query: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF Y V V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304
E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+ LDYE
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 886
Query: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
+VEA D +ATV + + D+ND PP FS+ +Y +++ DA+ G +
Sbjct: 887 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 946
Query: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416
+ AED D P ++ + + + + F V+ G V + L+ E + + L+V
Sbjct: 947 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 1006
Query: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475
A D G P MSS+ATV I + + P FT Y + E GT + + +
Sbjct: 1007 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
Query: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527
+SI+SGNEE+ F + + G++ + YVL VQA +
Sbjct: 1066 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
Query: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585
P + + + + + +E+ H P ED + ++ ATD+D Y V+
Sbjct: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
Query: 3586 FAL----KSEQKSLFKVNSHDGKI 3605
+ L E K F V ++ G I
Sbjct: 1181 YRLIIPPIKEGKEGFVVETYTGLI 1204
Score = 259 bits (662), Expect = 4e-68
Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 128
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 129 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
Query: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 187 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 247 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
Query: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 305 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 364 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 482
Query: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 483 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 538
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN P +++S
Sbjct: 539 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400
++IE + PP + P F + Y+ + E+ RV ++ + + + + I G
Sbjct: 598 ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
Query: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458
+ F+ + G + + K LD E Y + + +DG + V I V D NDN P
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
F P + E+ + + Q++ATD D ++ VH S+ + + FRI S G
Sbjct: 716 VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 769
Query: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
+YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN Y V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
Query: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630
E+ G+ +LQ+ A D D G N Y I + + F + P G +++ + PD
Sbjct: 830 ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 887
Query: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690
F++ PP AT V + V ++ P F + Y+ V + GT +
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740
+ A + S + Y V D IF + SG + T+ L+ E T+ ++L+
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797
+ A + M+S+ATV I ++ + P F +Y +SE A ++V + + +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1063
Query: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857
N +VY IV + F +++ TG I LD+ET + V DS
Sbjct: 1064 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1112
Query: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911
L + + +V IE+ D N++PPVF + + + + VL+V ATD D
Sbjct: 1113 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
Query: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
+ + Y L+ EG + F++++ +G++ + +N+ + ++ V +D
Sbjct: 1173 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 256 bits (655), Expect = 3e-67
Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 373 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 402
Query: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Y L + + DS + ++ L KD +++ D
Sbjct: 403 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 439
Query: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
LH + Y++ + T IT+ T
Sbjct: 440 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 465
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 466 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + + Y +
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 581
Query: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
T+ A D P S+ T + N++ P F + Y+ ++E +R+ +L++ AT
Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
Query: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271
EG I Y I +GDP + FN+ TG+L + LD E T Y L I ASD +
Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
Query: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
TV+++V DVNDN P+FD P + + E + V QV + D D+ N VHY +
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
N + F I +S+G I TA L+ E+ + L V + D S + + I + D++D
Sbjct: 757 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
N PVF Y V E P G + ++A D D + Y I S + F + +G
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502
++L P +++ F A V + V N Y P FS+ Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556
V + GT + V A D DP ++ Y + + + F + + +G+VIT
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
L+ E + V A D G ++ TV+++V+ + P+F EYR +++
Sbjct: 993 NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1049
Query: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
+G +V + A N I YS+ S + D I+ G + G + T
Sbjct: 1050 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1102
Query: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
V+A + +P K + VYI + P F + Y ++ED + ++
Sbjct: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
Query: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
V ++ +S + E +G FV+E TG IK F F
Sbjct: 1163 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
+V AT K D++ +V +D++V+ N + E T D + E +P
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1280
Score = 253 bits (647), Expect = 2e-66
Identities = 285/1097 (25%), Positives = 479/1097 (43%), Gaps = 114/1097 (10%)
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698
P+ A A + I + +N P F YQ + E+ +G TS + I A+ +
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1699 STLIYEVKD-------GDINGIFTINPYSGV---ITTQKALDYERTSSYQLIIQATNMAG 1748
I + KD D +FT+ +G+ +T + +D E +Y I A +
Sbjct: 432 D--IEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 1749 MASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNR 1807
+ VNIQ++D NDN P F Y + ++ P +S+++ + A DAD
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGS 540
Query: 1808 NALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
N + Y+I+ A+ F ++ +TG I ++ + V D+ P S
Sbjct: 541 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
Query: 1868 EVNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS 1926
V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++ G
Sbjct: 600 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGD 656
Query: 1927 LDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLH 1981
F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D+
Sbjct: 657 PQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 1982 FTQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
F S E N + +V + +N + YS+ N N F+I S + T
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--T 773
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+ +
Sbjct: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
Query: 2099 PGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIE 2153
GT I Q+ A D D G N + F ++P +G + L EAF ++I
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
Query: 2154 YGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP 2213
+ V G P +V + + +N PVF K Y V D TPI ++ A
Sbjct: 894 FLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 953
Query: 2214 EGQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDAL 2264
+ G + Y + D P F ++ D+G + L+ E T+ +KL + A D
Sbjct: 954 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 1013
Query: 2265 TGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHY 2324
+ TV +LV + P + +SE + GT +V + + + N+ + Y
Sbjct: 1014 PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVY 1069
Query: 2325 QIVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSE 2377
IV N D F I++ +G+I LD+E VQ +L+V + PS S+
Sbjct: 1070 SIVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
Query: 2378 VLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL--- 2434
V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y ++
Sbjct: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
Query: 2435 SGNDRTSFLMDSKSGVI 2451
+ F++++ +G+I
Sbjct: 1188 IKEGKEGFVVETYTGLI 1204
Score = 238 bits (607), Expect = 1e-61
Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)
Query: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 393
Query: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 446
Query: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 503
Query: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 504 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 560
Query: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
+G+IT A ++ +Y LTV A D S VYIEV N+ +P +
Sbjct: 561 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 620
Query: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++ T + L
Sbjct: 621 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 676
Query: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271
DRE + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 677 DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330
+ + A D D G N ++ YS+ GN + F I + ++ K Y L +
Sbjct: 736 ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
Query: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388
A D + ST L I+ + SP+ F N +TV+ + + ++ ++
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 843
Query: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438
+ L + I F G + + + LD E Q + VE D G
Sbjct: 844 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
Query: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495
T +A V +K D ND P FS+ Y ++ D + T I + A D D +
Sbjct: 904 TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
Query: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
V +D + F ++ +G + T L+ E L ++ D P + A
Sbjct: 962 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 1021
Query: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610
V + V + P FT Y V E A G+ V ++A N ++Y+I +GN
Sbjct: 1022 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1076
Query: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663
+ F I + G+I + D T +VL ++ + + P S TA V I +
Sbjct: 1077 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713
+N P F K Y V+E+ + TSV+ + A + T +I +K+G
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1194
Query: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1195 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 186 bits (473), Expect = 4e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 524 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 575
Query: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 576 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 635
Query: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 636 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
Query: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 696 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
Query: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 751 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 806
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 807 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 866
Query: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
L+P +G L L +SL + + + A D P ++V+
Sbjct: 867 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 915
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P F K + V D G
Sbjct: 916 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 943
Query: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1062
Query: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 1063 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1115
Query: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
Query: 1017 RPVSLSSVSFVEVEVVDVN 1035
V +S V+ ++++V+ N
Sbjct: 1236 ADVLVSVVNQLDMQVIVSN 1254
Score = 174 bits (441), Expect = 2e-42
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
Query: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 587
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
N + + +Y+ + N +P + + V ++
Sbjct: 588 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 697
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 698 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 757
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 758 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 874
Query: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 875 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 984
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 985 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1026
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L G + P F + V E G + I A + N
Sbjct: 1027 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1066
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
Query: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Query: 929 VNDCSPAFIPSSYSVKVLEDL 949
+ +P + K +EDL
Sbjct: 1247 DMQVIVSNVPPTLVEKKIEDL 1267
Score = 168 bits (426), Expect = 1e-40
Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 220 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 279
Query: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
TY I E TP + VT A D D G Y + F
Sbjct: 280 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 339
Query: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 340 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 392
Query: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 393 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 449
Query: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 450 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 501
Query: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 502 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 557
Query: 422 INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473
IN +GLI A + + Y L V + A+ T+ IE N P F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532
Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG+++ +
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 674
Query: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 675 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ V A D D + GN F + + + K N +++ + L
Sbjct: 732 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 788
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ ATDG +H + S+ + LA K+L
Sbjct: 789 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 810
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 811 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 863
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 864 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 923
Query: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 924 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 982
Query: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 983 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1039
Query: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1095
Query: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 1096 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1153
Query: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1154 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1213
Query: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1214 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1270
Score = 145 bits (367), Expect = 7e-34
Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
Query: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 426 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 484 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536
G ++ IL G + + + G++ A + Y L VQA D+ P + ++
Sbjct: 542 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594
+ + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++ + +
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 659
Query: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
+F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 660 VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 694
Score = 102 bits (253), Expect = 1e-20
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 505 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 558
Query: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 559 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 670
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 671 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
Query: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 780
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 781 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 833
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 894 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 951
Query: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 952 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 1010
Query: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 1011 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1067
Query: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1116
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
+ +V SKS N +++ N P F K F
Sbjct: 1117 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1150
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 1151 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1207
Query: 787 M 787
M
Sbjct: 1208 M 1208
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 1058 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1115
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1230
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1231 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1269
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 324 bits (830), Expect = 1e-87
Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 104 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 163
Query: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 164 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 223
Query: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 224 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 280
Query: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
++Y + T + AID D + + Y I+ G
Sbjct: 281 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 340
Query: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 341 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 392
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
E+ ++++ Y +S P + + L +
Sbjct: 393 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 425
Query: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 426 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 484
Query: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 485 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 542
Query: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S
Sbjct: 543 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 602
Query: 919 VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
+ T+ + + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N
Sbjct: 603 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 659
Query: 978 -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
D F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+
Sbjct: 660 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 717
Query: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
N + PY P V + N+ +G QV A D D+G +G++ YS+ + + L R +
Sbjct: 718 NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 771
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
+G I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y
Sbjct: 772 -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 830
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+V EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD
Sbjct: 831 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 887
Query: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267
E Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+
Sbjct: 888 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 943
Query: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322
+G PI +A D D P + + Y + D F ++ +G V +R
Sbjct: 944 -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1002
Query: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
I L + A D+G P SS+A + I + P IP E + V E +
Sbjct: 1003 PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1059
Query: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
VGV+S N + + IV GN + F G I + PLD E R+ Y + V+ D
Sbjct: 1060 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1118
Query: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
V + +V+I++ D N++ P F + Y +SED T +L+++ATD+D
Sbjct: 1119 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1178
Query: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
+ I I K F ++ TG++ TA + + ++ D
Sbjct: 1179 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1238
Query: 1548 NLARVIVNVEDANDHSPYFTN 1568
A V+V+V + D +N
Sbjct: 1239 GKADVLVSVVNQLDMQVIVSN 1259
Score = 311 bits (796), Expect = 1e-83
Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 254
Query: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
D I YS+ + P + N+ + +KA
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
Query: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 375 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
Query: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 434 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 490
Query: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 491 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 550
Query: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909
Y + +Q + F I+ TG I+ ++ T+ +V A+D A +S
Sbjct: 551 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 605
Query: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968
V + V N+ +P F Q +Y + E+ G V+ L DR+ + +Y I G+
Sbjct: 606 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 661
Query: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026
P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+
Sbjct: 662 PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 719
Query: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
PV D L + +N + +V A D D G NG + YSL N F +G +
Sbjct: 720 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 777
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144
T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y V EN
Sbjct: 778 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 837
Query: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199
+ +++A D D+G N V Y + + F++ +G + L + LD E Q++
Sbjct: 838 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 895
Query: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
S V A D G + TVT+ V D+ND PPVF +R Y V D GT + V+
Sbjct: 896 SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 954
Query: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314
A D R + Q F++ +G + L+ E F LVV A
Sbjct: 955 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 1014
Query: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373
D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A + N
Sbjct: 1015 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1069
Query: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426
I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA + +P+
Sbjct: 1070 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1129
Query: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ + I
Sbjct: 1130 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1189
Query: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
+ +E E FV++ + G++++A++F + + V A D
Sbjct: 1190 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1231
Score = 310 bits (795), Expect = 2e-83
Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
Query: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 379
Query: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 380 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
Query: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 436 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 493
Query: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 494 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 553
Query: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245
G Q F IN TGLIT ++ + L V D P ++ S V ++VL
Sbjct: 554 LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 611
Query: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304
N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +G+ F
Sbjct: 612 PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 666
Query: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362
+ TG+++ K S D IL I A D GRP +STA ++I +P+ F
Sbjct: 667 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 722
Query: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
D P+ N +V+E + + V + P N + + + GNF++ F G+I
Sbjct: 723 D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 778
Query: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V + E++
Sbjct: 779 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 838
Query: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534
T ILQIEA D D +SY + S F + P TG L LD+EA
Sbjct: 839 AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 895
Query: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
+I + F + A V V V+D ND+ P F+ +Y+ V A G+ + V A
Sbjct: 896 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 955
Query: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641
D D G A + ++ ++F++E V+ + + +EP TT+ F L +
Sbjct: 956 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 1011
Query: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699
D G P MS++A V+I V + P+F ++Y+ V+E GT V +ISA +
Sbjct: 1012 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1070
Query: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752
+++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1071 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1130
Query: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810
A V I+I DEN++ PVF Y G +SE A + S L ++ATD D+ ++
Sbjct: 1131 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1183
Query: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
+ Y+++ K+ F V++ TG I+T + ++F F V D L+ ++ V
Sbjct: 1184 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1243
Query: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
+++++V N P + + + + +L YV ++
Sbjct: 1244 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1284
Score = 271 bits (694), Expect = 8e-72
Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 254
Query: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292
L V + ++ P VP + + P TY +VT + +D
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
N + S SI+ G P D E + E D F ++L ++
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 371
Query: 347 AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
A+ D G P A ++I + F Y I E +P G
Sbjct: 372 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
Query: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 430 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 488
Query: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 489 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 548
Query: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565
ITY I F+IN+ TG+I+ ++ Y V+A+D P R S V
Sbjct: 549 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 607
Query: 566 IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624
I + N+ S P F ++ IS VG + + A D E + + Y I +G+ F
Sbjct: 608 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 666
Query: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683
L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 667 NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 713
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P FD P +++V E+ A
Sbjct: 714 ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 739
Query: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
+ ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y L +
Sbjct: 740 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 796
Query: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N
Sbjct: 797 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 856
Query: 864 GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917
V+Y + + + FA++ TG + + LD E+ +A+ + +EA D G
Sbjct: 857 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 912
Query: 918 SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975
+ T+ V + D+ND P F Y V D GT I + E DP +VRY
Sbjct: 913 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 971
Query: 976 VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
V+D FE+++ SG + L+ E + L V A D G PV +SS + V++
Sbjct: 972 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1030
Query: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
V LH P F V E + GT V ++A + + I YSI G+
Sbjct: 1031 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1080
Query: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139
F I++ +GVI LD ET SY L V A VV +T +VYIE++
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140
Query: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
D N++ P+ + Y V E++ SV++++A D D+ + + YR+ + F
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200
Query: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+ TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1201 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252
Score = 271 bits (694), Expect = 8e-72
Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)
Query: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
SD + YSIL G F M ++ ++L + + L +
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
Query: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 378 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
Query: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580
T + +ND+ F + G + + +DRE + + + A DG
Sbjct: 438 IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 494
Query: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
+ V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N ITY +
Sbjct: 495 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 554
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698
A D + I+ G + + + V+A D P ++S+ VYI V
Sbjct: 555 VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 610
Query: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755
LPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P+ +
Sbjct: 611 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 665
Query: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
F + + TG + L K LDRE++ + + A+ + D T V+I V D+NDN PVF+
Sbjct: 666 FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 723
Query: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
+ + + QV+A D D G NGQV YSL + + F I SN G I
Sbjct: 724 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 776
Query: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
T L+ E + VVA+D G ST ++++V DI+DN+PVF Y V+E
Sbjct: 777 YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 835
Query: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993
+ P G + + D D+ VSY I + FAL E + + R LD E
Sbjct: 836 NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 890
Query: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
E I FL + A D ++ T A V V V D+ND PV + Y ++ D
Sbjct: 891 PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 948
Query: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
I V A+DAD +RY + + S F ++ +SG + T L+ E ++
Sbjct: 949 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1008
Query: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
L+ A D G S+ + IL P F+ + Y ATK + V +
Sbjct: 1009 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1065
Query: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212
IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 1066 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1125
Query: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD G + +
Sbjct: 1126 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1185
Query: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329
Y LI ++GK F + TG I + + F V A D LS A V +
Sbjct: 1186 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1245
Query: 3330 NLTDVND 3336
++ + D
Sbjct: 1246 SVVNQLD 1252
Score = 261 bits (668), Expect = 9e-69
Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 86 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 140
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 141 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 200
Query: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
+ D EI D +++ + N N+ + T + V
Sbjct: 201 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 260
Query: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
+DG L P+++ VL P T +P + I I +
Sbjct: 261 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
Query: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 316 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 369
Query: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 370 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 430 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 489
Query: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 490 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 545
Query: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012
N +++Y I G +G F + ++ + + ++ Y L + A D +
Sbjct: 546 NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 602
Query: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069
V + V N+ SP Q+ Y+ + E + ++L + A D + S I Y++
Sbjct: 603 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 659
Query: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128
G F L +G L LDRE Y L+ A+DG + +++++ DVNDN
Sbjct: 660 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 719
Query: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185
PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F I +S+G
Sbjct: 720 PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 774
Query: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF Y V V
Sbjct: 775 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 833
Query: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304
E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+ LDYE
Sbjct: 834 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 891
Query: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
+VEA D +ATV + + D+ND PP FS+ +Y +++ DA+ G +
Sbjct: 892 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 951
Query: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416
+ AED D P ++ + + + + F V+ G V + L+ E + + L+V
Sbjct: 952 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 1011
Query: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475
A D G P MSS+ATV I + + P FT Y + E GT + + +
Sbjct: 1012 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1070
Query: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527
+SI+SGNEE+ F + + G++ + YVL VQA +
Sbjct: 1071 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1125
Query: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585
P + + + + + +E+ H P ED + ++ ATD+D Y V+
Sbjct: 1126 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1185
Query: 3586 FAL----KSEQKSLFKVNSHDGKI 3605
+ L E K F V ++ G I
Sbjct: 1186 YRLIIPPIKEGKEGFVVETYTGLI 1209
Score = 259 bits (662), Expect = 4e-68
Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 79 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 133
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 134 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 191
Query: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 192 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 251
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 252 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 309
Query: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 310 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 368
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 369 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 428
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 429 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 487
Query: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 488 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 543
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN P +++S
Sbjct: 544 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 602
Query: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400
++IE + PP + P F + Y+ + E+ RV ++ + + + + I G
Sbjct: 603 ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458
+ F+ + G + + K LD E Y + + +DG + V I V D NDN P
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
F P + E+ + + Q++ATD D ++ VH S+ + + FRI S G
Sbjct: 721 VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 774
Query: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
+YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN Y V
Sbjct: 775 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 834
Query: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630
E+ G+ +LQ+ A D D G N Y I + + F + P G +++ + PD
Sbjct: 835 ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 892
Query: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690
F++ PP AT V + V ++ P F + Y+ V + GT +
Sbjct: 893 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 950
Query: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740
+ A + S + Y V D IF + SG + T+ L+ E T+ ++L+
Sbjct: 951 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1010
Query: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797
+ A + M+S+ATV I ++ + P F +Y +SE A ++V + + +
Sbjct: 1011 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1068
Query: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857
N +VY IV + F +++ TG I LD+ET + V DS
Sbjct: 1069 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1117
Query: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911
L + + +V IE+ D N++PPVF + + + + VL+V ATD D
Sbjct: 1118 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1177
Query: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
+ + Y L+ EG + F++++ +G++ + +N+ + ++ V +D
Sbjct: 1178 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1231
Score = 256 bits (655), Expect = 3e-67
Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
Query: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 378 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 407
Query: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Y L + + DS + ++ L KD +++ D
Sbjct: 408 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 444
Query: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
LH + Y++ + T IT+ T
Sbjct: 445 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 470
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 471 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 527
Query: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + + Y +
Sbjct: 528 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 586
Query: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
T+ A D P S+ T + N++ P F + Y+ ++E +R+ +L++ AT
Sbjct: 587 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 646
Query: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271
EG I Y I +GDP + FN+ TG+L + LD E T Y L I ASD +
Sbjct: 647 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 706
Query: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
TV+++V DVNDN P+FD P + + E + V QV + D D+ N VHY +
Sbjct: 707 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 761
Query: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
N + F I +S+G I TA L+ E+ + L V + D S + + I + D++D
Sbjct: 762 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 819
Query: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
N PVF Y V E P G + ++A D D + Y I S + F + +G
Sbjct: 820 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 877
Query: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502
++L P +++ F A V + V N Y P FS+ Y
Sbjct: 878 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 937
Query: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556
V + GT + V A D DP ++ Y + + + F + + +G+VIT
Sbjct: 938 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 997
Query: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
L+ E + V A D G ++ TV+++V+ + P+F EYR +++
Sbjct: 998 NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1054
Query: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
+G +V + A N I YS+ S + D I+ G + G + T
Sbjct: 1055 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1107
Query: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
V+A + +P K + VYI + P F + Y ++ED + ++
Sbjct: 1108 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1167
Query: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
V ++ +S + E +G FV+E TG IK F F
Sbjct: 1168 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1225
Query: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
+V AT K D++ +V +D++V+ N + E T D + E +P
Sbjct: 1226 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1285
Score = 253 bits (647), Expect = 2e-66
Identities = 285/1097 (25%), Positives = 479/1097 (43%), Gaps = 114/1097 (10%)
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698
P+ A A + I + +N P F YQ + E+ +G TS + I A+ +
Sbjct: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
Query: 1699 STLIYEVKD-------GDINGIFTINPYSGV---ITTQKALDYERTSSYQLIIQATNMAG 1748
I + KD D +FT+ +G+ +T + +D E +Y I A +
Sbjct: 437 D--IEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 493
Query: 1749 MASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNR 1807
+ VNIQ++D NDN P F Y + ++ P +S+++ + A DAD
Sbjct: 494 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGS 545
Query: 1808 NALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
N + Y+I+ A+ F ++ +TG I ++ + V D+ P S
Sbjct: 546 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 604
Query: 1868 EVNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS 1926
V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++ G
Sbjct: 605 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGD 661
Query: 1927 LDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLH 1981
F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D+
Sbjct: 662 PQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 721
Query: 1982 FTQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
F S E N + +V + +N + YS+ N N F+I S + T
Sbjct: 722 FDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--T 778
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+ +
Sbjct: 779 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 838
Query: 2099 PGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIE 2153
GT I Q+ A D D G N + F ++P +G + L EAF ++I
Sbjct: 839 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 898
Query: 2154 YGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP 2213
+ V G P +V + + +N PVF K Y V D TPI ++ A
Sbjct: 899 FLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 958
Query: 2214 EGQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDAL 2264
+ G + Y + D P F ++ D+G + L+ E T+ +KL + A D
Sbjct: 959 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 1018
Query: 2265 TGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHY 2324
+ TV +LV + P + +SE + GT +V + + + N+ + Y
Sbjct: 1019 PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVY 1074
Query: 2325 QIVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSE 2377
IV N D F I++ +G+I LD+E VQ +L+V + PS S+
Sbjct: 1075 SIVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1132
Query: 2378 VLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL--- 2434
V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y ++
Sbjct: 1133 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1192
Query: 2435 SGNDRTSFLMDSKSGVI 2451
+ F++++ +G+I
Sbjct: 1193 IKEGKEGFVVETYTGLI 1209
Score = 238 bits (607), Expect = 1e-61
Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)
Query: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 161 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 220
Query: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 221 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 280
Query: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 281 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 340
Query: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 341 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 398
Query: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 399 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 451
Query: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 452 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 508
Query: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 509 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 565
Query: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
+G+IT A ++ +Y LTV A D S VYIEV N+ +P +
Sbjct: 566 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 625
Query: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++ T + L
Sbjct: 626 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 681
Query: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271
DRE + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 682 DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 740
Query: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330
+ + A D D G N ++ YS+ GN + F I + ++ K Y L +
Sbjct: 741 ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 795
Query: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388
A D + ST L I+ + SP+ F N +TV+ + + ++ ++
Sbjct: 796 ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 848
Query: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438
+ L + I F G + + + LD E Q + VE D G
Sbjct: 849 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 908
Query: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495
T +A V +K D ND P FS+ Y ++ D + T I + A D D +
Sbjct: 909 TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 966
Query: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
V +D + F ++ +G + T L+ E L ++ D P + A
Sbjct: 967 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 1026
Query: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610
V + V + P FT Y V E A G+ V ++A N ++Y+I +GN
Sbjct: 1027 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1081
Query: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663
+ F I + G+I + D T +VL ++ + + P S TA V I +
Sbjct: 1082 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1141
Query: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713
+N P F K Y V+E+ + TSV+ + A + T +I +K+G
Sbjct: 1142 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1199
Query: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1200 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252
Score = 186 bits (473), Expect = 4e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 358 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 417
Query: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 418 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 477
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 478 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 528
Query: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 529 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 580
Query: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 581 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 640
Query: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 641 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 700
Query: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 701 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 755
Query: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 756 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 811
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 812 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 871
Query: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
L+P +G L L +SL + + + A D P ++V+
Sbjct: 872 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 920
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P F K + V D G
Sbjct: 921 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 948
Query: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 949 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1008
Query: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 1009 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1067
Query: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 1068 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1120
Query: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 1121 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1180
Query: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 1181 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1240
Query: 1017 RPVSLSSVSFVEVEVVDVN 1035
V +S V+ ++++V+ N
Sbjct: 1241 ADVLVSVVNQLDMQVIVSN 1259
Score = 174 bits (441), Expect = 2e-42
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 474 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 532
Query: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 533 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 592
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
N + + +Y+ + N +P + + V ++
Sbjct: 593 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 649
Query: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 650 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 702
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 703 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 762
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 763 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 821
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 822 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 879
Query: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 880 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 937
Query: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 938 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 989
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 990 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1031
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L G + P F + V E G + I A + N
Sbjct: 1032 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1071
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 1072 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1131
Query: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 1132 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1191
Query: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 1192 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1251
Query: 929 VNDCSPAFIPSSYSVKVLEDL 949
+ +P + K +EDL
Sbjct: 1252 DMQVIVSNVPPTLVEKKIEDL 1272
Score = 168 bits (426), Expect = 1e-40
Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 225 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 284
Query: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
TY I E TP + VT A D D G Y + F
Sbjct: 285 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 344
Query: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 345 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 397
Query: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 398 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 454
Query: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 455 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 506
Query: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 507 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 562
Query: 422 INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473
IN +GLI A + + Y L V + A+ T+ IE N P F
Sbjct: 563 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 622
Query: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532
Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG+++ +
Sbjct: 623 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 679
Query: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 680 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 736
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ V A D D + GN F + + + K N +++ + L
Sbjct: 737 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 793
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ ATDG +H + S+ + LA K+L
Sbjct: 794 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 815
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 816 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 868
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 869 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 928
Query: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 929 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 987
Query: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 988 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1044
Query: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 1045 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1100
Query: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 1101 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1158
Query: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1159 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1218
Query: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1219 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1275
Score = 145 bits (367), Expect = 7e-34
Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 131 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 190
Query: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 191 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
Query: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
Query: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 370
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 371 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 430
Query: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 431 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 488
Query: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 489 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 546
Query: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536
G ++ IL G + + + G++ A + Y L VQA D+ P + ++
Sbjct: 547 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 605
Query: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594
+ + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++ + +
Sbjct: 606 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 664
Query: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
+F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 665 VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 699
Score = 102 bits (253), Expect = 1e-20
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 510 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 563
Query: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 564 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 619
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 620 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 675
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 676 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 729
Query: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 730 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 785
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 786 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 838
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 839 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 898
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 899 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 956
Query: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 957 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 1015
Query: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 1016 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1072
Query: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 1073 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1121
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
+ +V SKS N +++ N P F K F
Sbjct: 1122 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1155
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 1156 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1212
Query: 787 M 787
M
Sbjct: 1213 M 1213
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 1063 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1120
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1121 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1180
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1181 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1235
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1236 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1274
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 324 bits (830), Expect = 1e-87
Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
Query: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
Query: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 219 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 275
Query: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
++Y + T + AID D + + Y I+ G
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 387
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
E+ ++++ Y +S P + + L +
Sbjct: 388 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 421 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
Query: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 480 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 919 VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
+ T+ + + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
Query: 978 -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
D F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 712
Query: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
N + PY P V + N+ +G QV A D D+G +G++ YS+ + + L R +
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 766
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
+G I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y
Sbjct: 767 -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 825
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+V EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD
Sbjct: 826 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 882
Query: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267
E Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+
Sbjct: 883 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 938
Query: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322
+G PI +A D D P + + Y + D F ++ +G V +R
Sbjct: 939 -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
Query: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
I L + A D+G P SS+A + I + P IP E + V E +
Sbjct: 998 PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
VGV+S N + + IV GN + F G I + PLD E R+ Y + V+ D
Sbjct: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1113
Query: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
V + +V+I++ D N++ P F + Y +SED T +L+++ATD+D
Sbjct: 1114 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
Query: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
+ I I K F ++ TG++ TA + + ++ D
Sbjct: 1174 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
Query: 1548 NLARVIVNVEDANDHSPYFTN 1568
A V+V+V + D +N
Sbjct: 1234 GKADVLVSVVNQLDMQVIVSN 1254
Score = 311 bits (796), Expect = 1e-83
Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 249
Query: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
D I YS+ + P + N+ + +KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 370 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 485
Query: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 486 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909
Y + +Q + F I+ TG I+ ++ T+ +V A+D A +S
Sbjct: 546 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968
V + V N+ +P F Q +Y + E+ G V+ L DR+ + +Y I G+
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 656
Query: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026
P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+
Sbjct: 657 PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
PV D L + +N + +V A D D G NG + YSL N F +G +
Sbjct: 715 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 772
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144
T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y V EN
Sbjct: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199
+ +++A D D+G N V Y + + F++ +G + L + LD E Q++
Sbjct: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
S V A D G + TVT+ V D+ND PPVF +R Y V D GT + V+
Sbjct: 891 SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 949
Query: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314
A D R + Q F++ +G + L+ E F LVV A
Sbjct: 950 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 1009
Query: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373
D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A + N
Sbjct: 1010 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1064
Query: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426
I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA + +P+
Sbjct: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
Query: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ + I
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Query: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
+ +E E FV++ + G++++A++F + + V A D
Sbjct: 1185 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 310 bits (795), Expect = 2e-83
Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
Query: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 375 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245
G Q F IN TGLIT ++ + L V D P ++ S V ++VL
Sbjct: 549 LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
Query: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304
N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +G+ F
Sbjct: 607 PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 661
Query: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362
+ TG+++ K S D IL I A D GRP +STA ++I +P+ F
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 717
Query: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
D P+ N +V+E + + V + P N + + + GNF++ F G+I
Sbjct: 718 D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 773
Query: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V + E++
Sbjct: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
Query: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534
T ILQIEA D D +SY + S F + P TG L LD+EA
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
+I + F + A V V V+D ND+ P F+ +Y+ V A G+ + V A
Sbjct: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641
D D G A + ++ ++F++E V+ + + +EP TT+ F L +
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 1006
Query: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699
D G P MS++A V+I V + P+F ++Y+ V+E GT V +ISA +
Sbjct: 1007 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
Query: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752
+++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
Query: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810
A V I+I DEN++ PVF Y G +SE A + S L ++ATD D+ ++
Sbjct: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1178
Query: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
+ Y+++ K+ F V++ TG I+T + ++F F V D L+ ++ V
Sbjct: 1179 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1238
Query: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
+++++V N P + + + + +L YV ++
Sbjct: 1239 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1279
Score = 271 bits (694), Expect = 8e-72
Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 249
Query: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292
L V + ++ P VP + + P TY +VT + +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
N + S SI+ G P D E + E D F ++L ++
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 366
Query: 347 AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
A+ D G P A ++I + F Y I E +P G
Sbjct: 367 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 484 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565
ITY I F+IN+ TG+I+ ++ Y V+A+D P R S V
Sbjct: 544 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 602
Query: 566 IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624
I + N+ S P F ++ IS VG + + A D E + + Y I +G+ F
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 661
Query: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683
L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 662 NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 708
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P FD P +++V E+ A
Sbjct: 709 ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 734
Query: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
+ ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y L +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 791
Query: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N
Sbjct: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851
Query: 864 GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917
V+Y + + + FA++ TG + + LD E+ +A+ + +EA D G
Sbjct: 852 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 907
Query: 918 SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975
+ T+ V + D+ND P F Y V D GT I + E DP +VRY
Sbjct: 908 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 966
Query: 976 VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
V+D FE+++ SG + L+ E + L V A D G PV +SS + V++
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
V LH P F V E + GT V ++A + + I YSI G+
Sbjct: 1026 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1075
Query: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139
F I++ +GVI LD ET SY L V A VV +T +VYIE++
Sbjct: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
Query: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
D N++ P+ + Y V E++ SV++++A D D+ + + YR+ + F
Sbjct: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1195
Query: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+ TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1196 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 271 bits (694), Expect = 8e-72
Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)
Query: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
SD + YSIL G F M ++ ++L + + L +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580
T + +ND+ F + G + + +DRE + + + A DG
Sbjct: 433 IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 489
Query: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
+ V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N ITY +
Sbjct: 490 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 549
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698
A D + I+ G + + + V+A D P ++S+ VYI V
Sbjct: 550 VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755
LPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P+ +
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 660
Query: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
F + + TG + L K LDRE++ + + A+ + D T V+I V D+NDN PVF+
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 718
Query: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
+ + + QV+A D D G NGQV YSL + + F I SN G I
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 771
Query: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
T L+ E + VVA+D G ST ++++V DI+DN+PVF Y V+E
Sbjct: 772 YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
Query: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993
+ P G + + D D+ VSY I + FAL E + + R LD E
Sbjct: 831 NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 885
Query: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
E I FL + A D ++ T A V V V D+ND PV + Y ++ D
Sbjct: 886 PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
I V A+DAD +RY + + S F ++ +SG + T L+ E ++
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
L+ A D G S+ + IL P F+ + Y ATK + V +
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212
IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 1061 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
Query: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD G + +
Sbjct: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
Query: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329
Y LI ++GK F + TG I + + F V A D LS A V +
Sbjct: 1181 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Query: 3330 NLTDVND 3336
++ + D
Sbjct: 1241 SVVNQLD 1247
Score = 261 bits (668), Expect = 9e-69
Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 81 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 135
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 136 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
Query: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
+ D EI D +++ + N N+ + T + V
Sbjct: 196 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 255
Query: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
+DG L P+++ VL P T +P + I I +
Sbjct: 256 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 311 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 364
Query: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 485 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 540
Query: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012
N +++Y I G +G F + ++ + + ++ Y L + A D +
Sbjct: 541 NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069
V + V N+ SP Q+ Y+ + E + ++L + A D + S I Y++
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 654
Query: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128
G F L +G L LDRE Y L+ A+DG + +++++ DVNDN
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185
PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F I +S+G
Sbjct: 715 PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 769
Query: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF Y V V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304
E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+ LDYE
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 886
Query: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
+VEA D +ATV + + D+ND PP FS+ +Y +++ DA+ G +
Sbjct: 887 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 946
Query: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416
+ AED D P ++ + + + + F V+ G V + L+ E + + L+V
Sbjct: 947 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 1006
Query: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475
A D G P MSS+ATV I + + P FT Y + E GT + + +
Sbjct: 1007 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
Query: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527
+SI+SGNEE+ F + + G++ + YVL VQA +
Sbjct: 1066 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
Query: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585
P + + + + + +E+ H P ED + ++ ATD+D Y V+
Sbjct: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
Query: 3586 FAL----KSEQKSLFKVNSHDGKI 3605
+ L E K F V ++ G I
Sbjct: 1181 YRLIIPPIKEGKEGFVVETYTGLI 1204
Score = 259 bits (662), Expect = 4e-68
Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 128
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 129 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
Query: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 187 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 247 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
Query: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 305 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 364 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 482
Query: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 483 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 538
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN P +++S
Sbjct: 539 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400
++IE + PP + P F + Y+ + E+ RV ++ + + + + I G
Sbjct: 598 ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
Query: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458
+ F+ + G + + K LD E Y + + +DG + V I V D NDN P
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
F P + E+ + + Q++ATD D ++ VH S+ + + FRI S G
Sbjct: 716 VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 769
Query: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
+YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN Y V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
Query: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630
E+ G+ +LQ+ A D D G N Y I + + F + P G +++ + PD
Sbjct: 830 ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 887
Query: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690
F++ PP AT V + V ++ P F + Y+ V + GT +
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740
+ A + S + Y V D IF + SG + T+ L+ E T+ ++L+
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797
+ A + M+S+ATV I ++ + P F +Y +SE A ++V + + +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1063
Query: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857
N +VY IV + F +++ TG I LD+ET + V DS
Sbjct: 1064 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1112
Query: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911
L + + +V IE+ D N++PPVF + + + + VL+V ATD D
Sbjct: 1113 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
Query: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
+ + Y L+ EG + F++++ +G++ + +N+ + ++ V +D
Sbjct: 1173 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 256 bits (655), Expect = 3e-67
Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 373 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 402
Query: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Y L + + DS + ++ L KD +++ D
Sbjct: 403 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 439
Query: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
LH + Y++ + T IT+ T
Sbjct: 440 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 465
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 466 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + + Y +
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 581
Query: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
T+ A D P S+ T + N++ P F + Y+ ++E +R+ +L++ AT
Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
Query: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271
EG I Y I +GDP + FN+ TG+L + LD E T Y L I ASD +
Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
Query: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
TV+++V DVNDN P+FD P + + E + V QV + D D+ N VHY +
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
N + F I +S+G I TA L+ E+ + L V + D S + + I + D++D
Sbjct: 757 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
N PVF Y V E P G + ++A D D + Y I S + F + +G
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502
++L P +++ F A V + V N Y P FS+ Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556
V + GT + V A D DP ++ Y + + + F + + +G+VIT
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
L+ E + V A D G ++ TV+++V+ + P+F EYR +++
Sbjct: 993 NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1049
Query: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
+G +V + A N I YS+ S + D I+ G + G + T
Sbjct: 1050 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1102
Query: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
V+A + +P K + VYI + P F + Y ++ED + ++
Sbjct: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
Query: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
V ++ +S + E +G FV+E TG IK F F
Sbjct: 1163 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
+V AT K D++ +V +D++V+ N + E T D + E +P
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1280
Score = 253 bits (647), Expect = 2e-66
Identities = 285/1097 (25%), Positives = 479/1097 (43%), Gaps = 114/1097 (10%)
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698
P+ A A + I + +N P F YQ + E+ +G TS + I A+ +
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1699 STLIYEVKD-------GDINGIFTINPYSGV---ITTQKALDYERTSSYQLIIQATNMAG 1748
I + KD D +FT+ +G+ +T + +D E +Y I A +
Sbjct: 432 D--IEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 1749 MASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNR 1807
+ VNIQ++D NDN P F Y + ++ P +S+++ + A DAD
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGS 540
Query: 1808 NALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
N + Y+I+ A+ F ++ +TG I ++ + V D+ P S
Sbjct: 541 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
Query: 1868 EVNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS 1926
V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++ G
Sbjct: 600 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGD 656
Query: 1927 LDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLH 1981
F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D+
Sbjct: 657 PQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 1982 FTQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
F S E N + +V + +N + YS+ N N F+I S + T
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--T 773
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+ +
Sbjct: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
Query: 2099 PGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIE 2153
GT I Q+ A D D G N + F ++P +G + L EAF ++I
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
Query: 2154 YGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP 2213
+ V G P +V + + +N PVF K Y V D TPI ++ A
Sbjct: 894 FLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 953
Query: 2214 EGQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDAL 2264
+ G + Y + D P F ++ D+G + L+ E T+ +KL + A D
Sbjct: 954 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 1013
Query: 2265 TGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHY 2324
+ TV +LV + P + +SE + GT +V + + + N+ + Y
Sbjct: 1014 PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVY 1069
Query: 2325 QIVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSE 2377
IV N D F I++ +G+I LD+E VQ +L+V + PS S+
Sbjct: 1070 SIVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
Query: 2378 VLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL--- 2434
V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y ++
Sbjct: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
Query: 2435 SGNDRTSFLMDSKSGVI 2451
+ F++++ +G+I
Sbjct: 1188 IKEGKEGFVVETYTGLI 1204
Score = 238 bits (607), Expect = 1e-61
Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)
Query: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 393
Query: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 446
Query: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 503
Query: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 504 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 560
Query: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
+G+IT A ++ +Y LTV A D S VYIEV N+ +P +
Sbjct: 561 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 620
Query: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++ T + L
Sbjct: 621 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 676
Query: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271
DRE + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 677 DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330
+ + A D D G N ++ YS+ GN + F I + ++ K Y L +
Sbjct: 736 ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
Query: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388
A D + ST L I+ + SP+ F N +TV+ + + ++ ++
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 843
Query: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438
+ L + I F G + + + LD E Q + VE D G
Sbjct: 844 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
Query: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495
T +A V +K D ND P FS+ Y ++ D + T I + A D D +
Sbjct: 904 TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
Query: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
V +D + F ++ +G + T L+ E L ++ D P + A
Sbjct: 962 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 1021
Query: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610
V + V + P FT Y V E A G+ V ++A N ++Y+I +GN
Sbjct: 1022 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1076
Query: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663
+ F I + G+I + D T +VL ++ + + P S TA V I +
Sbjct: 1077 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713
+N P F K Y V+E+ + TSV+ + A + T +I +K+G
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1194
Query: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1195 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 186 bits (473), Expect = 4e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 524 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 575
Query: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 576 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 635
Query: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 636 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
Query: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 696 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
Query: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 751 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 806
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 807 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 866
Query: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
L+P +G L L +SL + + + A D P ++V+
Sbjct: 867 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 915
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P F K + V D G
Sbjct: 916 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 943
Query: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1062
Query: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 1063 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1115
Query: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
Query: 1017 RPVSLSSVSFVEVEVVDVN 1035
V +S V+ ++++V+ N
Sbjct: 1236 ADVLVSVVNQLDMQVIVSN 1254
Score = 174 bits (441), Expect = 2e-42
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
Query: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 587
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
N + + +Y+ + N +P + + V ++
Sbjct: 588 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 697
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 698 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 757
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 758 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 874
Query: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 875 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 984
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 985 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1026
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L G + P F + V E G + I A + N
Sbjct: 1027 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1066
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
Query: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Query: 929 VNDCSPAFIPSSYSVKVLEDL 949
+ +P + K +EDL
Sbjct: 1247 DMQVIVSNVPPTLVEKKIEDL 1267
Score = 168 bits (426), Expect = 1e-40
Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 220 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 279
Query: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
TY I E TP + VT A D D G Y + F
Sbjct: 280 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 339
Query: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 340 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 392
Query: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 393 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 449
Query: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 450 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 501
Query: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 502 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 557
Query: 422 INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473
IN +GLI A + + Y L V + A+ T+ IE N P F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532
Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG+++ +
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 674
Query: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 675 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ V A D D + GN F + + + K N +++ + L
Sbjct: 732 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 788
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ ATDG +H + S+ + LA K+L
Sbjct: 789 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 810
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 811 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 863
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 864 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 923
Query: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 924 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 982
Query: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 983 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1039
Query: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1095
Query: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 1096 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1153
Query: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1154 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1213
Query: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1214 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1270
Score = 145 bits (367), Expect = 7e-34
Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
Query: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 426 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 484 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536
G ++ IL G + + + G++ A + Y L VQA D+ P + ++
Sbjct: 542 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594
+ + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++ + +
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 659
Query: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
+F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 660 VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 694
Score = 102 bits (253), Expect = 1e-20
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 505 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 558
Query: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 559 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 670
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 671 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
Query: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 780
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 781 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 833
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 894 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 951
Query: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 952 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 1010
Query: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 1011 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1067
Query: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1116
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
+ +V SKS N +++ N P F K F
Sbjct: 1117 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1150
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 1151 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1207
Query: 787 M 787
M
Sbjct: 1208 M 1208
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 1058 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1115
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1230
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1231 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1269
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 324 bits (830), Expect = 1e-87
Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 77 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 136
Query: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 137 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 196
Query: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 197 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 253
Query: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
++Y + T + AID D + + Y I+ G
Sbjct: 254 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313
Query: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 314 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 365
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
E+ ++++ Y +S P + + L +
Sbjct: 366 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
Query: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 399 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 457
Query: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 458 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515
Query: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S
Sbjct: 516 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 919 VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
+ T+ + + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N
Sbjct: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 632
Query: 978 -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
D F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+
Sbjct: 633 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 690
Query: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
N + PY P V + N+ +G QV A D D+G +G++ YS+ + + L R +
Sbjct: 691 NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 744
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
+G I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y
Sbjct: 745 -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 803
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+V EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD
Sbjct: 804 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 860
Query: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267
E Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+
Sbjct: 861 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 916
Query: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322
+G PI +A D D P + + Y + D F ++ +G V +R
Sbjct: 917 -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 975
Query: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
I L + A D+G P SS+A + I + P IP E + V E +
Sbjct: 976 PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1032
Query: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
VGV+S N + + IV GN + F G I + PLD E R+ Y + V+ D
Sbjct: 1033 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1091
Query: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
V + +V+I++ D N++ P F + Y +SED T +L+++ATD+D
Sbjct: 1092 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1151
Query: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
+ I I K F ++ TG++ TA + + ++ D
Sbjct: 1152 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1211
Query: 1548 NLARVIVNVEDANDHSPYFTN 1568
A V+V+V + D +N
Sbjct: 1212 GKADVLVSVVNQLDMQVIVSN 1232
Score = 311 bits (796), Expect = 1e-83
Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 227
Query: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 228 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 287
Query: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
D I YS+ + P + N+ + +KA
Sbjct: 288 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 347
Query: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 348 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 406
Query: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 407 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 463
Query: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 464 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 523
Query: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909
Y + +Q + F I+ TG I+ ++ T+ +V A+D A +S
Sbjct: 524 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968
V + V N+ +P F Q +Y + E+ G V+ L DR+ + +Y I G+
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 634
Query: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026
P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+
Sbjct: 635 PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 692
Query: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
PV D L + +N + +V A D D G NG + YSL N F +G +
Sbjct: 693 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 750
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144
T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y V EN
Sbjct: 751 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 810
Query: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199
+ +++A D D+G N V Y + + F++ +G + L + LD E Q++
Sbjct: 811 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 868
Query: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
S V A D G + TVT+ V D+ND PPVF +R Y V D GT + V+
Sbjct: 869 SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 927
Query: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314
A D R + Q F++ +G + L+ E F LVV A
Sbjct: 928 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 987
Query: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373
D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A + N
Sbjct: 988 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1042
Query: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426
I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA + +P+
Sbjct: 1043 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1102
Query: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ + I
Sbjct: 1103 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1162
Query: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
+ +E E FV++ + G++++A++F + + V A D
Sbjct: 1163 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Score = 310 bits (795), Expect = 2e-83
Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 113 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 172
Query: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 173 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 232
Query: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 233 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 292
Query: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 293 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 352
Query: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 353 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
Query: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 409 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 466
Query: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 526
Query: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245
G Q F IN TGLIT ++ + L V D P ++ S V ++VL
Sbjct: 527 LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 584
Query: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304
N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +G+ F
Sbjct: 585 PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 639
Query: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362
+ TG+++ K S D IL I A D GRP +STA ++I +P+ F
Sbjct: 640 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 695
Query: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
D P+ N +V+E + + V + P N + + + GNF++ F G+I
Sbjct: 696 D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 751
Query: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V + E++
Sbjct: 752 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 811
Query: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534
T ILQIEA D D +SY + S F + P TG L LD+EA
Sbjct: 812 AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 868
Query: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
+I + F + A V V V+D ND+ P F+ +Y+ V A G+ + V A
Sbjct: 869 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 928
Query: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641
D D G A + ++ ++F++E V+ + + +EP TT+ F L +
Sbjct: 929 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 984
Query: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699
D G P MS++A V+I V + P+F ++Y+ V+E GT V +ISA +
Sbjct: 985 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1043
Query: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752
+++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1044 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1103
Query: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810
A V I+I DEN++ PVF Y G +SE A + S L ++ATD D+ ++
Sbjct: 1104 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1156
Query: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
+ Y+++ K+ F V++ TG I+T + ++F F V D L+ ++ V
Sbjct: 1157 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1216
Query: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
+++++V N P + + + + +L YV ++
Sbjct: 1217 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1257
Score = 271 bits (694), Expect = 8e-72
Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 227
Query: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292
L V + ++ P VP + + P TY +VT + +D
Sbjct: 228 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 287
Query: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
N + S SI+ G P D E + E D F ++L ++
Sbjct: 288 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 344
Query: 347 AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
A+ D G P A ++I + F Y I E +P G
Sbjct: 345 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 402
Query: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 403 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 461
Query: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 462 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 521
Query: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565
ITY I F+IN+ TG+I+ ++ Y V+A+D P R S V
Sbjct: 522 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 580
Query: 566 IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624
I + N+ S P F ++ IS VG + + A D E + + Y I +G+ F
Sbjct: 581 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 639
Query: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683
L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 640 NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 686
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P FD P +++V E+ A
Sbjct: 687 ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 712
Query: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
+ ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y L +
Sbjct: 713 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 769
Query: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N
Sbjct: 770 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 829
Query: 864 GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917
V+Y + + + FA++ TG + + LD E+ +A+ + +EA D G
Sbjct: 830 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 885
Query: 918 SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975
+ T+ V + D+ND P F Y V D GT I + E DP +VRY
Sbjct: 886 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 944
Query: 976 VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
V+D FE+++ SG + L+ E + L V A D G PV +SS + V++
Sbjct: 945 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1003
Query: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
V LH P F V E + GT V ++A + + I YSI G+
Sbjct: 1004 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1053
Query: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139
F I++ +GVI LD ET SY L V A VV +T +VYIE++
Sbjct: 1054 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1113
Query: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
D N++ P+ + Y V E++ SV++++A D D+ + + YR+ + F
Sbjct: 1114 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1173
Query: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+ TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1174 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 271 bits (694), Expect = 8e-72
Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)
Query: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
SD + YSIL G F M ++ ++L + + L +
Sbjct: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
Query: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 351 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 410
Query: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580
T + +ND+ F + G + + +DRE + + + A DG
Sbjct: 411 IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 467
Query: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
+ V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N ITY +
Sbjct: 468 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 527
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698
A D + I+ G + + + V+A D P ++S+ VYI V
Sbjct: 528 VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 583
Query: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755
LPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P+ +
Sbjct: 584 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 638
Query: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
F + + TG + L K LDRE++ + + A+ + D T V+I V D+NDN PVF+
Sbjct: 639 FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 696
Query: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
+ + + QV+A D D G NGQV YSL + + F I SN G I
Sbjct: 697 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 749
Query: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
T L+ E + VVA+D G ST ++++V DI+DN+PVF Y V+E
Sbjct: 750 YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 808
Query: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993
+ P G + + D D+ VSY I + FAL E + + R LD E
Sbjct: 809 NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 863
Query: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
E I FL + A D ++ T A V V V D+ND PV + Y ++ D
Sbjct: 864 PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 921
Query: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
I V A+DAD +RY + + S F ++ +SG + T L+ E ++
Sbjct: 922 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 981
Query: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
L+ A D G S+ + IL P F+ + Y ATK + V +
Sbjct: 982 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1038
Query: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212
IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 1039 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1098
Query: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD G + +
Sbjct: 1099 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1158
Query: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329
Y LI ++GK F + TG I + + F V A D LS A V +
Sbjct: 1159 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1218
Query: 3330 NLTDVND 3336
++ + D
Sbjct: 1219 SVVNQLD 1225
Score = 261 bits (668), Expect = 9e-69
Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 59 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 113
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 114 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 173
Query: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
+ D EI D +++ + N N+ + T + V
Sbjct: 174 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 233
Query: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
+DG L P+++ VL P T +P + I I +
Sbjct: 234 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 289 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 342
Query: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 343 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 402
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 403 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 462
Query: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 463 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 518
Query: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012
N +++Y I G +G F + ++ + + ++ Y L + A D +
Sbjct: 519 NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069
V + V N+ SP Q+ Y+ + E + ++L + A D + S I Y++
Sbjct: 576 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 632
Query: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128
G F L +G L LDRE Y L+ A+DG + +++++ DVNDN
Sbjct: 633 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 692
Query: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185
PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F I +S+G
Sbjct: 693 PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 747
Query: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF Y V V
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 806
Query: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304
E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+ LDYE
Sbjct: 807 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 864
Query: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
+VEA D +ATV + + D+ND PP FS+ +Y +++ DA+ G +
Sbjct: 865 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 924
Query: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416
+ AED D P ++ + + + + F V+ G V + L+ E + + L+V
Sbjct: 925 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 984
Query: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475
A D G P MSS+ATV I + + P FT Y + E GT + + +
Sbjct: 985 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1043
Query: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527
+SI+SGNEE+ F + + G++ + YVL VQA +
Sbjct: 1044 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1098
Query: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585
P + + + + + +E+ H P ED + ++ ATD+D Y V+
Sbjct: 1099 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1158
Query: 3586 FAL----KSEQKSLFKVNSHDGKI 3605
+ L E K F V ++ G I
Sbjct: 1159 YRLIIPPIKEGKEGFVVETYTGLI 1182
Score = 259 bits (662), Expect = 4e-68
Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 52 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 106
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 107 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 164
Query: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 165 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 224
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 225 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 282
Query: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 283 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 342 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 401
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 402 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 460
Query: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 461 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 516
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN P +++S
Sbjct: 517 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400
++IE + PP + P F + Y+ + E+ RV ++ + + + + I G
Sbjct: 576 ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 633
Query: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458
+ F+ + G + + K LD E Y + + +DG + V I V D NDN P
Sbjct: 634 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 693
Query: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
F P + E+ + + Q++ATD D ++ VH S+ + + FRI S G
Sbjct: 694 VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 747
Query: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
+YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN Y V
Sbjct: 748 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 807
Query: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630
E+ G+ +LQ+ A D D G N Y I + + F + P G +++ + PD
Sbjct: 808 ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 865
Query: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690
F++ PP AT V + V ++ P F + Y+ V + GT +
Sbjct: 866 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
Query: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740
+ A + S + Y V D IF + SG + T+ L+ E T+ ++L+
Sbjct: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 983
Query: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797
+ A + M+S+ATV I ++ + P F +Y +SE A ++V + + +
Sbjct: 984 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1041
Query: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857
N +VY IV + F +++ TG I LD+ET + V DS
Sbjct: 1042 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1090
Query: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911
L + + +V IE+ D N++PPVF + + + + VL+V ATD D
Sbjct: 1091 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1150
Query: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
+ + Y L+ EG + F++++ +G++ + +N+ + ++ V +D
Sbjct: 1151 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1204
Score = 256 bits (655), Expect = 3e-67
Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 350
Query: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 351 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 380
Query: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Y L + + DS + ++ L KD +++ D
Sbjct: 381 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 417
Query: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
LH + Y++ + T IT+ T
Sbjct: 418 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 443
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 444 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 500
Query: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + + Y +
Sbjct: 501 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 559
Query: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
T+ A D P S+ T + N++ P F + Y+ ++E +R+ +L++ AT
Sbjct: 560 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 619
Query: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271
EG I Y I +GDP + FN+ TG+L + LD E T Y L I ASD +
Sbjct: 620 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 679
Query: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
TV+++V DVNDN P+FD P + + E + V QV + D D+ N VHY +
Sbjct: 680 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 734
Query: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
N + F I +S+G I TA L+ E+ + L V + D S + + I + D++D
Sbjct: 735 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
Query: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
N PVF Y V E P G + ++A D D + Y I S + F + +G
Sbjct: 793 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 850
Query: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502
++L P +++ F A V + V N Y P FS+ Y
Sbjct: 851 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 910
Query: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556
V + GT + V A D DP ++ Y + + + F + + +G+VIT
Sbjct: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 970
Query: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
L+ E + V A D G ++ TV+++V+ + P+F EYR +++
Sbjct: 971 NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1027
Query: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
+G +V + A N I YS+ S + D I+ G + G + T
Sbjct: 1028 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1080
Query: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
V+A + +P K + VYI + P F + Y ++ED + ++
Sbjct: 1081 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1140
Query: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
V ++ +S + E +G FV+E TG IK F F
Sbjct: 1141 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1198
Query: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
+V AT K D++ +V +D++V+ N + E T D + E +P
Sbjct: 1199 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1258
Score = 253 bits (647), Expect = 2e-66
Identities = 285/1097 (25%), Positives = 479/1097 (43%), Gaps = 114/1097 (10%)
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 170 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 289
Query: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 290 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 349
Query: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698
P+ A A + I + +N P F YQ + E+ +G TS + I A+ +
Sbjct: 350 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 409
Query: 1699 STLIYEVKD-------GDINGIFTINPYSGV---ITTQKALDYERTSSYQLIIQATNMAG 1748
I + KD D +FT+ +G+ +T + +D E +Y I A +
Sbjct: 410 D--IEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 466
Query: 1749 MASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNR 1807
+ VNIQ++D NDN P F Y + ++ P +S+++ + A DAD
Sbjct: 467 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGS 518
Query: 1808 NALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
N + Y+I+ A+ F ++ +TG I ++ + V D+ P S
Sbjct: 519 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 577
Query: 1868 EVNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS 1926
V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++ G
Sbjct: 578 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGD 634
Query: 1927 LDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLH 1981
F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D+
Sbjct: 635 PQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 694
Query: 1982 FTQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
F S E N + +V + +N + YS+ N N F+I S + T
Sbjct: 695 FDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--T 751
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+ +
Sbjct: 752 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 811
Query: 2099 PGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIE 2153
GT I Q+ A D D G N + F ++P +G + L EAF ++I
Sbjct: 812 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 871
Query: 2154 YGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP 2213
+ V G P +V + + +N PVF K Y V D TPI ++ A
Sbjct: 872 FLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 931
Query: 2214 EGQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDAL 2264
+ G + Y + D P F ++ D+G + L+ E T+ +KL + A D
Sbjct: 932 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 991
Query: 2265 TGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHY 2324
+ TV +LV + P + +SE + GT +V + + + N+ + Y
Sbjct: 992 PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVY 1047
Query: 2325 QIVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSE 2377
IV N D F I++ +G+I LD+E VQ +L+V + PS S+
Sbjct: 1048 SIVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1105
Query: 2378 VLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL--- 2434
V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y ++
Sbjct: 1106 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1165
Query: 2435 SGNDRTSFLMDSKSGVI 2451
+ F++++ +G+I
Sbjct: 1166 IKEGKEGFVVETYTGLI 1182
Score = 238 bits (607), Expect = 1e-61
Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)
Query: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 134 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 193
Query: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 194 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 253
Query: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 254 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 313
Query: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 314 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 371
Query: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 372 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 424
Query: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 425 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 481
Query: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 482 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 538
Query: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
+G+IT A ++ +Y LTV A D S VYIEV N+ +P +
Sbjct: 539 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 598
Query: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++ T + L
Sbjct: 599 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 654
Query: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271
DRE + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 655 DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 713
Query: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330
+ + A D D G N ++ YS+ GN + F I + ++ K Y L +
Sbjct: 714 ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 768
Query: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388
A D + ST L I+ + SP+ F N +TV+ + + ++ ++
Sbjct: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 821
Query: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438
+ L + I F G + + + LD E Q + VE D G
Sbjct: 822 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 881
Query: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495
T +A V +K D ND P FS+ Y ++ D + T I + A D D +
Sbjct: 882 TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 939
Query: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
V +D + F ++ +G + T L+ E L ++ D P + A
Sbjct: 940 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 999
Query: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610
V + V + P FT Y V E A G+ V ++A N ++Y+I +GN
Sbjct: 1000 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1054
Query: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663
+ F I + G+I + D T +VL ++ + + P S TA V I +
Sbjct: 1055 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1114
Query: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713
+N P F K Y V+E+ + TSV+ + A + T +I +K+G
Sbjct: 1115 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1172
Query: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1173 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 186 bits (473), Expect = 4e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 331 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 390
Query: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 391 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 450
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 451 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 501
Query: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 502 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 553
Query: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 554 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 613
Query: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 614 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 673
Query: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 674 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 728
Query: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 729 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 784
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 785 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 844
Query: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
L+P +G L L +SL + + + A D P ++V+
Sbjct: 845 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 893
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P F K + V D G
Sbjct: 894 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 921
Query: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 922 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 981
Query: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 982 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1040
Query: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 1041 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1093
Query: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
Query: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1213
Query: 1017 RPVSLSSVSFVEVEVVDVN 1035
V +S V+ ++++V+ N
Sbjct: 1214 ADVLVSVVNQLDMQVIVSN 1232
Score = 174 bits (441), Expect = 2e-42
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 447 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 505
Query: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 506 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 565
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
N + + +Y+ + N +P + + V ++
Sbjct: 566 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 622
Query: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 623 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 675
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 676 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 735
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 736 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 794
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 795 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 852
Query: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 853 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 910
Query: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 911 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 962
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 963 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1004
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L G + P F + V E G + I A + N
Sbjct: 1005 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1044
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 1045 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1104
Query: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 1105 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1164
Query: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 1165 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
Query: 929 VNDCSPAFIPSSYSVKVLEDL 949
+ +P + K +EDL
Sbjct: 1225 DMQVIVSNVPPTLVEKKIEDL 1245
Score = 168 bits (426), Expect = 1e-40
Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 198 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 257
Query: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
TY I E TP + VT A D D G Y + F
Sbjct: 258 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 317
Query: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 318 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 370
Query: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 371 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 427
Query: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 428 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 479
Query: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 480 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 535
Query: 422 INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473
IN +GLI A + + Y L V + A+ T+ IE N P F
Sbjct: 536 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 595
Query: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532
Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG+++ +
Sbjct: 596 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 652
Query: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 653 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 709
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ V A D D + GN F + + + K N +++ + L
Sbjct: 710 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 766
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ ATDG +H + S+ + LA K+L
Sbjct: 767 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 788
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 789 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 841
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 842 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 901
Query: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 902 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 960
Query: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 961 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1017
Query: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 1018 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1073
Query: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 1074 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1131
Query: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1132 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1191
Query: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1192 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1248
Score = 145 bits (367), Expect = 7e-34
Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 104 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 163
Query: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 164 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223
Query: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 224 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 283
Query: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 284 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 343
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 344 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 403
Query: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 404 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 461
Query: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 462 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 519
Query: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536
G ++ IL G + + + G++ A + Y L VQA D+ P + ++
Sbjct: 520 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594
+ + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++ + +
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 637
Query: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
+F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 638 VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 672
Score = 102 bits (253), Expect = 1e-20
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 483 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 536
Query: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 537 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 592
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 593 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 648
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 649 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 702
Query: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 703 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 758
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 759 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 811
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 812 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 871
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 872 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 929
Query: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 930 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 988
Query: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 989 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1045
Query: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 1046 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1094
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
+ +V SKS N +++ N P F K F
Sbjct: 1095 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1128
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 1129 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1185
Query: 787 M 787
M
Sbjct: 1186 M 1186
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 1036 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1093
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1094 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1153
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1154 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1208
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1209 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1247
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 324 bits (830), Expect = 1e-87
Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
Query: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
Query: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 219 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 275
Query: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
++Y + T + AID D + + Y I+ G
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 387
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
E+ ++++ Y +S P + + L +
Sbjct: 388 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 421 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
Query: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 480 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 919 VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
+ T+ + + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
Query: 978 -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
D F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 712
Query: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
N + PY P V + N+ +G QV A D D+G +G++ YS+ + + L R +
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 766
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
+G I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y
Sbjct: 767 -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 825
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+V EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD
Sbjct: 826 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 882
Query: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267
E Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+
Sbjct: 883 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 938
Query: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322
+G PI +A D D P + + Y + D F ++ +G V +R
Sbjct: 939 -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
Query: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
I L + A D+G P SS+A + I + P IP E + V E +
Sbjct: 998 PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
VGV+S N + + IV GN + F G I + PLD E R+ Y + V+ D
Sbjct: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1113
Query: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
V + +V+I++ D N++ P F + Y +SED T +L+++ATD+D
Sbjct: 1114 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
Query: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
+ I I K F ++ TG++ TA + + ++ D
Sbjct: 1174 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
Query: 1548 NLARVIVNVEDANDHSPYFTN 1568
A V+V+V + D +N
Sbjct: 1234 GKADVLVSVVNQLDMQVIVSN 1254
Score = 311 bits (796), Expect = 1e-83
Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 249
Query: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
D I YS+ + P + N+ + +KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 370 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 485
Query: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 486 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909
Y + +Q + F I+ TG I+ ++ T+ +V A+D A +S
Sbjct: 546 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968
V + V N+ +P F Q +Y + E+ G V+ L DR+ + +Y I G+
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 656
Query: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026
P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+
Sbjct: 657 PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
PV D L + +N + +V A D D G NG + YSL N F +G +
Sbjct: 715 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 772
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144
T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y V EN
Sbjct: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199
+ +++A D D+G N V Y + + F++ +G + L + LD E Q++
Sbjct: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
S V A D G + TVT+ V D+ND PPVF +R Y V D GT + V+
Sbjct: 891 SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 949
Query: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314
A D R + Q F++ +G + L+ E F LVV A
Sbjct: 950 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 1009
Query: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373
D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A + N
Sbjct: 1010 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1064
Query: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426
I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA + +P+
Sbjct: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
Query: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ + I
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Query: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
+ +E E FV++ + G++++A++F + + V A D
Sbjct: 1185 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 310 bits (795), Expect = 2e-83
Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
Query: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 375 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245
G Q F IN TGLIT ++ + L V D P ++ S V ++VL
Sbjct: 549 LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
Query: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304
N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +G+ F
Sbjct: 607 PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 661
Query: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362
+ TG+++ K S D IL I A D GRP +STA ++I +P+ F
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 717
Query: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
D P+ N +V+E + + V + P N + + + GNF++ F G+I
Sbjct: 718 D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 773
Query: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V + E++
Sbjct: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
Query: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534
T ILQIEA D D +SY + S F + P TG L LD+EA
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
+I + F + A V V V+D ND+ P F+ +Y+ V A G+ + V A
Sbjct: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641
D D G A + ++ ++F++E V+ + + +EP TT+ F L +
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 1006
Query: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699
D G P MS++A V+I V + P+F ++Y+ V+E GT V +ISA +
Sbjct: 1007 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
Query: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752
+++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
Query: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810
A V I+I DEN++ PVF Y G +SE A + S L ++ATD D+ ++
Sbjct: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1178
Query: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
+ Y+++ K+ F V++ TG I+T + ++F F V D L+ ++ V
Sbjct: 1179 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1238
Query: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
+++++V N P + + + + +L YV ++
Sbjct: 1239 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1279
Score = 271 bits (694), Expect = 8e-72
Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 249
Query: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292
L V + ++ P VP + + P TY +VT + +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
N + S SI+ G P D E + E D F ++L ++
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 366
Query: 347 AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
A+ D G P A ++I + F Y I E +P G
Sbjct: 367 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 484 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565
ITY I F+IN+ TG+I+ ++ Y V+A+D P R S V
Sbjct: 544 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 602
Query: 566 IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624
I + N+ S P F ++ IS VG + + A D E + + Y I +G+ F
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 661
Query: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683
L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 662 NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 708
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P FD P +++V E+ A
Sbjct: 709 ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 734
Query: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
+ ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y L +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 791
Query: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N
Sbjct: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851
Query: 864 GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917
V+Y + + + FA++ TG + + LD E+ +A+ + +EA D G
Sbjct: 852 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 907
Query: 918 SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975
+ T+ V + D+ND P F Y V D GT I + E DP +VRY
Sbjct: 908 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 966
Query: 976 VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
V+D FE+++ SG + L+ E + L V A D G PV +SS + V++
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
V LH P F V E + GT V ++A + + I YSI G+
Sbjct: 1026 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1075
Query: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139
F I++ +GVI LD ET SY L V A VV +T +VYIE++
Sbjct: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
Query: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
D N++ P+ + Y V E++ SV++++A D D+ + + YR+ + F
Sbjct: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1195
Query: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+ TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1196 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 271 bits (694), Expect = 8e-72
Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)
Query: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
SD + YSIL G F M ++ ++L + + L +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580
T + +ND+ F + G + + +DRE + + + A DG
Sbjct: 433 IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 489
Query: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
+ V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N ITY +
Sbjct: 490 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 549
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698
A D + I+ G + + + V+A D P ++S+ VYI V
Sbjct: 550 VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755
LPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P+ +
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 660
Query: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
F + + TG + L K LDRE++ + + A+ + D T V+I V D+NDN PVF+
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 718
Query: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
+ + + QV+A D D G NGQV YSL + + F I SN G I
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 771
Query: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
T L+ E + VVA+D G ST ++++V DI+DN+PVF Y V+E
Sbjct: 772 YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
Query: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993
+ P G + + D D+ VSY I + FAL E + + R LD E
Sbjct: 831 NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 885
Query: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
E I FL + A D ++ T A V V V D+ND PV + Y ++ D
Sbjct: 886 PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
I V A+DAD +RY + + S F ++ +SG + T L+ E ++
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
L+ A D G S+ + IL P F+ + Y ATK + V +
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212
IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 1061 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
Query: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD G + +
Sbjct: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
Query: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329
Y LI ++GK F + TG I + + F V A D LS A V +
Sbjct: 1181 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Query: 3330 NLTDVND 3336
++ + D
Sbjct: 1241 SVVNQLD 1247
Score = 261 bits (668), Expect = 9e-69
Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 81 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 135
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 136 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
Query: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
+ D EI D +++ + N N+ + T + V
Sbjct: 196 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 255
Query: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
+DG L P+++ VL P T +P + I I +
Sbjct: 256 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 311 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 364
Query: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 485 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 540
Query: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012
N +++Y I G +G F + ++ + + ++ Y L + A D +
Sbjct: 541 NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069
V + V N+ SP Q+ Y+ + E + ++L + A D + S I Y++
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 654
Query: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128
G F L +G L LDRE Y L+ A+DG + +++++ DVNDN
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185
PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F I +S+G
Sbjct: 715 PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 769
Query: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF Y V V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304
E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+ LDYE
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 886
Query: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
+VEA D +ATV + + D+ND PP FS+ +Y +++ DA+ G +
Sbjct: 887 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 946
Query: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416
+ AED D P ++ + + + + F V+ G V + L+ E + + L+V
Sbjct: 947 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 1006
Query: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475
A D G P MSS+ATV I + + P FT Y + E GT + + +
Sbjct: 1007 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
Query: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527
+SI+SGNEE+ F + + G++ + YVL VQA +
Sbjct: 1066 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
Query: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585
P + + + + + +E+ H P ED + ++ ATD+D Y V+
Sbjct: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
Query: 3586 FAL----KSEQKSLFKVNSHDGKI 3605
+ L E K F V ++ G I
Sbjct: 1181 YRLIIPPIKEGKEGFVVETYTGLI 1204
Score = 259 bits (662), Expect = 4e-68
Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 128
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 129 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
Query: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 187 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 247 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
Query: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 305 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 364 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 482
Query: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 483 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 538
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN P +++S
Sbjct: 539 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400
++IE + PP + P F + Y+ + E+ RV ++ + + + + I G
Sbjct: 598 ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
Query: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458
+ F+ + G + + K LD E Y + + +DG + V I V D NDN P
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
F P + E+ + + Q++ATD D ++ VH S+ + + FRI S G
Sbjct: 716 VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 769
Query: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
+YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN Y V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
Query: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630
E+ G+ +LQ+ A D D G N Y I + + F + P G +++ + PD
Sbjct: 830 ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 887
Query: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690
F++ PP AT V + V ++ P F + Y+ V + GT +
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740
+ A + S + Y V D IF + SG + T+ L+ E T+ ++L+
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797
+ A + M+S+ATV I ++ + P F +Y +SE A ++V + + +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1063
Query: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857
N +VY IV + F +++ TG I LD+ET + V DS
Sbjct: 1064 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1112
Query: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911
L + + +V IE+ D N++PPVF + + + + VL+V ATD D
Sbjct: 1113 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
Query: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
+ + Y L+ EG + F++++ +G++ + +N+ + ++ V +D
Sbjct: 1173 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 256 bits (655), Expect = 3e-67
Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 373 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 402
Query: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Y L + + DS + ++ L KD +++ D
Sbjct: 403 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 439
Query: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
LH + Y++ + T IT+ T
Sbjct: 440 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 465
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 466 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + + Y +
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 581
Query: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
T+ A D P S+ T + N++ P F + Y+ ++E +R+ +L++ AT
Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
Query: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271
EG I Y I +GDP + FN+ TG+L + LD E T Y L I ASD +
Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
Query: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
TV+++V DVNDN P+FD P + + E + V QV + D D+ N VHY +
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
N + F I +S+G I TA L+ E+ + L V + D S + + I + D++D
Sbjct: 757 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
N PVF Y V E P G + ++A D D + Y I S + F + +G
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502
++L P +++ F A V + V N Y P FS+ Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556
V + GT + V A D DP ++ Y + + + F + + +G+VIT
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
L+ E + V A D G ++ TV+++V+ + P+F EYR +++
Sbjct: 993 NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1049
Query: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
+G +V + A N I YS+ S + D I+ G + G + T
Sbjct: 1050 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1102
Query: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
V+A + +P K + VYI + P F + Y ++ED + ++
Sbjct: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
Query: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
V ++ +S + E +G FV+E TG IK F F
Sbjct: 1163 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
+V AT K D++ +V +D++V+ N + E T D + E +P
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1280
Score = 253 bits (647), Expect = 2e-66
Identities = 285/1097 (25%), Positives = 479/1097 (43%), Gaps = 114/1097 (10%)
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698
P+ A A + I + +N P F YQ + E+ +G TS + I A+ +
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1699 STLIYEVKD-------GDINGIFTINPYSGV---ITTQKALDYERTSSYQLIIQATNMAG 1748
I + KD D +FT+ +G+ +T + +D E +Y I A +
Sbjct: 432 D--IEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 1749 MASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNR 1807
+ VNIQ++D NDN P F Y + ++ P +S+++ + A DAD
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGS 540
Query: 1808 NALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
N + Y+I+ A+ F ++ +TG I ++ + V D+ P S
Sbjct: 541 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
Query: 1868 EVNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS 1926
V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++ G
Sbjct: 600 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGD 656
Query: 1927 LDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLH 1981
F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D+
Sbjct: 657 PQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 1982 FTQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
F S E N + +V + +N + YS+ N N F+I S + T
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--T 773
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+ +
Sbjct: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
Query: 2099 PGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIE 2153
GT I Q+ A D D G N + F ++P +G + L EAF ++I
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
Query: 2154 YGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP 2213
+ V G P +V + + +N PVF K Y V D TPI ++ A
Sbjct: 894 FLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 953
Query: 2214 EGQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDAL 2264
+ G + Y + D P F ++ D+G + L+ E T+ +KL + A D
Sbjct: 954 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 1013
Query: 2265 TGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHY 2324
+ TV +LV + P + +SE + GT +V + + + N+ + Y
Sbjct: 1014 PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVY 1069
Query: 2325 QIVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSE 2377
IV N D F I++ +G+I LD+E VQ +L+V + PS S+
Sbjct: 1070 SIVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
Query: 2378 VLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL--- 2434
V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y ++
Sbjct: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
Query: 2435 SGNDRTSFLMDSKSGVI 2451
+ F++++ +G+I
Sbjct: 1188 IKEGKEGFVVETYTGLI 1204
Score = 238 bits (607), Expect = 1e-61
Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)
Query: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 393
Query: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 446
Query: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 503
Query: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 504 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 560
Query: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
+G+IT A ++ +Y LTV A D S VYIEV N+ +P +
Sbjct: 561 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 620
Query: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++ T + L
Sbjct: 621 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 676
Query: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271
DRE + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 677 DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330
+ + A D D G N ++ YS+ GN + F I + ++ K Y L +
Sbjct: 736 ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
Query: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388
A D + ST L I+ + SP+ F N +TV+ + + ++ ++
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 843
Query: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438
+ L + I F G + + + LD E Q + VE D G
Sbjct: 844 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
Query: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495
T +A V +K D ND P FS+ Y ++ D + T I + A D D +
Sbjct: 904 TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
Query: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
V +D + F ++ +G + T L+ E L ++ D P + A
Sbjct: 962 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 1021
Query: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610
V + V + P FT Y V E A G+ V ++A N ++Y+I +GN
Sbjct: 1022 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1076
Query: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663
+ F I + G+I + D T +VL ++ + + P S TA V I +
Sbjct: 1077 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713
+N P F K Y V+E+ + TSV+ + A + T +I +K+G
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1194
Query: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1195 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 186 bits (473), Expect = 4e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 524 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 575
Query: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 576 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 635
Query: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 636 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
Query: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 696 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
Query: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 751 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 806
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 807 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 866
Query: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
L+P +G L L +SL + + + A D P ++V+
Sbjct: 867 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 915
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P F K + V D G
Sbjct: 916 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 943
Query: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1062
Query: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 1063 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1115
Query: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
Query: 1017 RPVSLSSVSFVEVEVVDVN 1035
V +S V+ ++++V+ N
Sbjct: 1236 ADVLVSVVNQLDMQVIVSN 1254
Score = 174 bits (441), Expect = 2e-42
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
Query: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 587
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
N + + +Y+ + N +P + + V ++
Sbjct: 588 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 697
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 698 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 757
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 758 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 874
Query: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 875 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 984
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 985 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1026
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L G + P F + V E G + I A + N
Sbjct: 1027 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1066
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
Query: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Query: 929 VNDCSPAFIPSSYSVKVLEDL 949
+ +P + K +EDL
Sbjct: 1247 DMQVIVSNVPPTLVEKKIEDL 1267
Score = 168 bits (426), Expect = 1e-40
Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 220 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 279
Query: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
TY I E TP + VT A D D G Y + F
Sbjct: 280 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 339
Query: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 340 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 392
Query: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 393 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 449
Query: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 450 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 501
Query: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 502 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 557
Query: 422 INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473
IN +GLI A + + Y L V + A+ T+ IE N P F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532
Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG+++ +
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 674
Query: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 675 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ V A D D + GN F + + + K N +++ + L
Sbjct: 732 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 788
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ ATDG +H + S+ + LA K+L
Sbjct: 789 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 810
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 811 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 863
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 864 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 923
Query: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 924 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 982
Query: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 983 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1039
Query: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1095
Query: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 1096 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1153
Query: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1154 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1213
Query: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1214 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1270
Score = 145 bits (367), Expect = 7e-34
Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
Query: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 426 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 484 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536
G ++ IL G + + + G++ A + Y L VQA D+ P + ++
Sbjct: 542 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594
+ + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++ + +
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 659
Query: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
+F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 660 VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 694
Score = 102 bits (253), Expect = 1e-20
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 505 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 558
Query: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 559 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 670
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 671 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
Query: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 780
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 781 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 833
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 894 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 951
Query: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 952 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 1010
Query: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 1011 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1067
Query: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1116
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
+ +V SKS N +++ N P F K F
Sbjct: 1117 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1150
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 1151 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1207
Query: 787 M 787
M
Sbjct: 1208 M 1208
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 1058 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1115
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1230
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1231 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1269
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 324 bits (830), Expect = 1e-87
Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
Query: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
Query: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 219 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 275
Query: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
++Y + T + AID D + + Y I+ G
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 387
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
E+ ++++ Y +S P + + L +
Sbjct: 388 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 421 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
Query: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 480 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 919 VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
+ T+ + + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
Query: 978 -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
D F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 712
Query: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
N + PY P V + N+ +G QV A D D+G +G++ YS+ + + L R +
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 766
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
+G I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y
Sbjct: 767 -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 825
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+V EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD
Sbjct: 826 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 882
Query: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267
E Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+
Sbjct: 883 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 938
Query: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322
+G PI +A D D P + + Y + D F ++ +G V +R
Sbjct: 939 -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
Query: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
I L + A D+G P SS+A + I + P IP E + V E +
Sbjct: 998 PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1054
Query: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
VGV+S N + + IV GN + F G I + PLD E R+ Y + V+ D
Sbjct: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1113
Query: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
V + +V+I++ D N++ P F + Y +SED T +L+++ATD+D
Sbjct: 1114 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
Query: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
+ I I K F ++ TG++ TA + + ++ D
Sbjct: 1174 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
Query: 1548 NLARVIVNVEDANDHSPYFTN 1568
A V+V+V + D +N
Sbjct: 1234 GKADVLVSVVNQLDMQVIVSN 1254
Score = 311 bits (796), Expect = 1e-83
Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 249
Query: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
D I YS+ + P + N+ + +KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 370 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 485
Query: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 486 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909
Y + +Q + F I+ TG I+ ++ T+ +V A+D A +S
Sbjct: 546 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968
V + V N+ +P F Q +Y + E+ G V+ L DR+ + +Y I G+
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 656
Query: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026
P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+
Sbjct: 657 PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
PV D L + +N + +V A D D G NG + YSL N F +G +
Sbjct: 715 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 772
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144
T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y V EN
Sbjct: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199
+ +++A D D+G N V Y + + F++ +G + L + LD E Q++
Sbjct: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
S V A D G + TVT+ V D+ND PPVF +R Y V D GT + V+
Sbjct: 891 SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 949
Query: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314
A D R + Q F++ +G + L+ E F LVV A
Sbjct: 950 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 1009
Query: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373
D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A + N
Sbjct: 1010 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1064
Query: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426
I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA + +P+
Sbjct: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
Query: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ + I
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
Query: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
+ +E E FV++ + G++++A++F + + V A D
Sbjct: 1185 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 310 bits (795), Expect = 2e-83
Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
Query: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 375 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245
G Q F IN TGLIT ++ + L V D P ++ S V ++VL
Sbjct: 549 LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
Query: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304
N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +G+ F
Sbjct: 607 PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 661
Query: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362
+ TG+++ K S D IL I A D GRP +STA ++I +P+ F
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 717
Query: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
D P+ N +V+E + + V + P N + + + GNF++ F G+I
Sbjct: 718 D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 773
Query: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V + E++
Sbjct: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
Query: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534
T ILQIEA D D +SY + S F + P TG L LD+EA
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 890
Query: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
+I + F + A V V V+D ND+ P F+ +Y+ V A G+ + V A
Sbjct: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
Query: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641
D D G A + ++ ++F++E V+ + + +EP TT+ F L +
Sbjct: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 1006
Query: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699
D G P MS++A V+I V + P+F ++Y+ V+E GT V +ISA +
Sbjct: 1007 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
Query: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752
+++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
Query: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810
A V I+I DEN++ PVF Y G +SE A + S L ++ATD D+ ++
Sbjct: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1178
Query: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
+ Y+++ K+ F V++ TG I+T + ++F F V D L+ ++ V
Sbjct: 1179 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1238
Query: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
+++++V N P + + + + +L YV ++
Sbjct: 1239 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1279
Score = 271 bits (694), Expect = 8e-72
Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 249
Query: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292
L V + ++ P VP + + P TY +VT + +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
N + S SI+ G P D E + E D F ++L ++
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 366
Query: 347 AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
A+ D G P A ++I + F Y I E +P G
Sbjct: 367 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 484 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565
ITY I F+IN+ TG+I+ ++ Y V+A+D P R S V
Sbjct: 544 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 602
Query: 566 IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624
I + N+ S P F ++ IS VG + + A D E + + Y I +G+ F
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 661
Query: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683
L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 662 NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 708
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P FD P +++V E+ A
Sbjct: 709 ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 734
Query: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
+ ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y L +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 791
Query: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N
Sbjct: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851
Query: 864 GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917
V+Y + + + FA++ TG + + LD E+ +A+ + +EA D G
Sbjct: 852 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 907
Query: 918 SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975
+ T+ V + D+ND P F Y V D GT I + E DP +VRY
Sbjct: 908 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 966
Query: 976 VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
V+D FE+++ SG + L+ E + L V A D G PV +SS + V++
Sbjct: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
V LH P F V E + GT V ++A + + I YSI G+
Sbjct: 1026 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1075
Query: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139
F I++ +GVI LD ET SY L V A VV +T +VYIE++
Sbjct: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
Query: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
D N++ P+ + Y V E++ SV++++A D D+ + + YR+ + F
Sbjct: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1195
Query: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+ TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1196 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 271 bits (694), Expect = 8e-72
Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)
Query: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
SD + YSIL G F M ++ ++L + + L +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580
T + +ND+ F + G + + +DRE + + + A DG
Sbjct: 433 IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 489
Query: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
+ V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N ITY +
Sbjct: 490 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 549
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698
A D + I+ G + + + V+A D P ++S+ VYI V
Sbjct: 550 VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Query: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755
LPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P+ +
Sbjct: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 660
Query: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
F + + TG + L K LDRE++ + + A+ + D T V+I V D+NDN PVF+
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 718
Query: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
+ + + QV+A D D G NGQV YSL + + F I SN G I
Sbjct: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 771
Query: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
T L+ E + VVA+D G ST ++++V DI+DN+PVF Y V+E
Sbjct: 772 YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
Query: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993
+ P G + + D D+ VSY I + FAL E + + R LD E
Sbjct: 831 NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 885
Query: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
E I FL + A D ++ T A V V V D+ND PV + Y ++ D
Sbjct: 886 PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
Query: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
I V A+DAD +RY + + S F ++ +SG + T L+ E ++
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
L+ A D G S+ + IL P F+ + Y ATK + V +
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
Query: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212
IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 1061 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
Query: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD G + +
Sbjct: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
Query: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329
Y LI ++GK F + TG I + + F V A D LS A V +
Sbjct: 1181 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Query: 3330 NLTDVND 3336
++ + D
Sbjct: 1241 SVVNQLD 1247
Score = 261 bits (668), Expect = 9e-69
Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 81 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 135
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 136 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
Query: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
+ D EI D +++ + N N+ + T + V
Sbjct: 196 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 255
Query: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
+DG L P+++ VL P T +P + I I +
Sbjct: 256 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 311 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 364
Query: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 485 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 540
Query: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012
N +++Y I G +G F + ++ + + ++ Y L + A D +
Sbjct: 541 NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069
V + V N+ SP Q+ Y+ + E + ++L + A D + S I Y++
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 654
Query: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128
G F L +G L LDRE Y L+ A+DG + +++++ DVNDN
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
Query: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185
PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F I +S+G
Sbjct: 715 PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 769
Query: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF Y V V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304
E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+ LDYE
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 886
Query: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
+VEA D +ATV + + D+ND PP FS+ +Y +++ DA+ G +
Sbjct: 887 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 946
Query: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416
+ AED D P ++ + + + + F V+ G V + L+ E + + L+V
Sbjct: 947 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 1006
Query: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475
A D G P MSS+ATV I + + P FT Y + E GT + + +
Sbjct: 1007 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
Query: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527
+SI+SGNEE+ F + + G++ + YVL VQA +
Sbjct: 1066 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
Query: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585
P + + + + + +E+ H P ED + ++ ATD+D Y V+
Sbjct: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
Query: 3586 FAL----KSEQKSLFKVNSHDGKI 3605
+ L E K F V ++ G I
Sbjct: 1181 YRLIIPPIKEGKEGFVVETYTGLI 1204
Score = 259 bits (662), Expect = 4e-68
Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 128
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 129 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
Query: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 187 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 247 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
Query: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 305 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 364 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 482
Query: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 483 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 538
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN P +++S
Sbjct: 539 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400
++IE + PP + P F + Y+ + E+ RV ++ + + + + I G
Sbjct: 598 ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
Query: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458
+ F+ + G + + K LD E Y + + +DG + V I V D NDN P
Sbjct: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
Query: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
F P + E+ + + Q++ATD D ++ VH S+ + + FRI S G
Sbjct: 716 VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 769
Query: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
+YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN Y V
Sbjct: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
Query: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630
E+ G+ +LQ+ A D D G N Y I + + F + P G +++ + PD
Sbjct: 830 ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 887
Query: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690
F++ PP AT V + V ++ P F + Y+ V + GT +
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740
+ A + S + Y V D IF + SG + T+ L+ E T+ ++L+
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797
+ A + M+S+ATV I ++ + P F +Y +SE A ++V + + +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1063
Query: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857
N +VY IV + F +++ TG I LD+ET + V DS
Sbjct: 1064 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1112
Query: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911
L + + +V IE+ D N++PPVF + + + + VL+V ATD D
Sbjct: 1113 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
Query: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
+ + Y L+ EG + F++++ +G++ + +N+ + ++ V +D
Sbjct: 1173 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
Score = 256 bits (655), Expect = 3e-67
Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 373 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 402
Query: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Y L + + DS + ++ L KD +++ D
Sbjct: 403 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 439
Query: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
LH + Y++ + T IT+ T
Sbjct: 440 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 465
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 466 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + + Y +
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 581
Query: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
T+ A D P S+ T + N++ P F + Y+ ++E +R+ +L++ AT
Sbjct: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
Query: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271
EG I Y I +GDP + FN+ TG+L + LD E T Y L I ASD +
Sbjct: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
Query: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
TV+++V DVNDN P+FD P + + E + V QV + D D+ N VHY +
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
N + F I +S+G I TA L+ E+ + L V + D S + + I + D++D
Sbjct: 757 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
N PVF Y V E P G + ++A D D + Y I S + F + +G
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502
++L P +++ F A V + V N Y P FS+ Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556
V + GT + V A D DP ++ Y + + + F + + +G+VIT
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
Query: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
L+ E + V A D G ++ TV+++V+ + P+F EYR +++
Sbjct: 993 NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1049
Query: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
+G +V + A N I YS+ S + D I+ G + G + T
Sbjct: 1050 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1102
Query: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
V+A + +P K + VYI + P F + Y ++ED + ++
Sbjct: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
Query: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
V ++ +S + E +G FV+E TG IK F F
Sbjct: 1163 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1220
Query: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
+V AT K D++ +V +D++V+ N + E T D + E +P
Sbjct: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1280
Score = 253 bits (647), Expect = 2e-66
Identities = 285/1097 (25%), Positives = 479/1097 (43%), Gaps = 114/1097 (10%)
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
Query: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
Query: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698
P+ A A + I + +N P F YQ + E+ +G TS + I A+ +
Sbjct: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
Query: 1699 STLIYEVKD-------GDINGIFTINPYSGV---ITTQKALDYERTSSYQLIIQATNMAG 1748
I + KD D +FT+ +G+ +T + +D E +Y I A +
Sbjct: 432 D--IEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
Query: 1749 MASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNR 1807
+ VNIQ++D NDN P F Y + ++ P +S+++ + A DAD
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGS 540
Query: 1808 NALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
N + Y+I+ A+ F ++ +TG I ++ + V D+ P S
Sbjct: 541 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
Query: 1868 EVNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS 1926
V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++ G
Sbjct: 600 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGD 656
Query: 1927 LDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLH 1981
F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D+
Sbjct: 657 PQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 1982 FTQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
F S E N + +V + +N + YS+ N N F+I S + T
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--T 773
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+ +
Sbjct: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
Query: 2099 PGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIE 2153
GT I Q+ A D D G N + F ++P +G + L EAF ++I
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
Query: 2154 YGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP 2213
+ V G P +V + + +N PVF K Y V D TPI ++ A
Sbjct: 894 FLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 953
Query: 2214 EGQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDAL 2264
+ G + Y + D P F ++ D+G + L+ E T+ +KL + A D
Sbjct: 954 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 1013
Query: 2265 TGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHY 2324
+ TV +LV + P + +SE + GT +V + + + N+ + Y
Sbjct: 1014 PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVY 1069
Query: 2325 QIVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSE 2377
IV N D F I++ +G+I LD+E VQ +L+V + PS S+
Sbjct: 1070 SIVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
Query: 2378 VLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL--- 2434
V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y ++
Sbjct: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
Query: 2435 SGNDRTSFLMDSKSGVI 2451
+ F++++ +G+I
Sbjct: 1188 IKEGKEGFVVETYTGLI 1204
Score = 238 bits (607), Expect = 1e-61
Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)
Query: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 393
Query: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 446
Query: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 503
Query: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 504 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 560
Query: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
+G+IT A ++ +Y LTV A D S VYIEV N+ +P +
Sbjct: 561 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 620
Query: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++ T + L
Sbjct: 621 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 676
Query: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271
DRE + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 677 DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
Query: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330
+ + A D D G N ++ YS+ GN + F I + ++ K Y L +
Sbjct: 736 ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
Query: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388
A D + ST L I+ + SP+ F N +TV+ + + ++ ++
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 843
Query: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438
+ L + I F G + + + LD E Q + VE D G
Sbjct: 844 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
Query: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495
T +A V +K D ND P FS+ Y ++ D + T I + A D D +
Sbjct: 904 TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
Query: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
V +D + F ++ +G + T L+ E L ++ D P + A
Sbjct: 962 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 1021
Query: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610
V + V + P FT Y V E A G+ V ++A N ++Y+I +GN
Sbjct: 1022 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1076
Query: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663
+ F I + G+I + D T +VL ++ + + P S TA V I +
Sbjct: 1077 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713
+N P F K Y V+E+ + TSV+ + A + T +I +K+G
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1194
Query: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1195 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 186 bits (473), Expect = 4e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 524 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 575
Query: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 576 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 635
Query: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 636 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
Query: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 696 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
Query: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 751 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 806
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 807 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 866
Query: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
L+P +G L L +SL + + + A D P ++V+
Sbjct: 867 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 915
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P F K + V D G
Sbjct: 916 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 943
Query: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
Query: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1062
Query: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 1063 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1115
Query: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
Query: 1017 RPVSLSSVSFVEVEVVDVN 1035
V +S V+ ++++V+ N
Sbjct: 1236 ADVLVSVVNQLDMQVIVSN 1254
Score = 174 bits (441), Expect = 2e-42
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 469 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
Query: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 587
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
N + + +Y+ + N +P + + V ++
Sbjct: 588 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
Query: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 697
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 698 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 757
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 758 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 874
Query: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 875 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 932
Query: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 984
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 985 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1026
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L G + P F + V E G + I A + N
Sbjct: 1027 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1066
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
Query: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
Query: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Query: 929 VNDCSPAFIPSSYSVKVLEDL 949
+ +P + K +EDL
Sbjct: 1247 DMQVIVSNVPPTLVEKKIEDL 1267
Score = 168 bits (426), Expect = 1e-40
Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 220 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 279
Query: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
TY I E TP + VT A D D G Y + F
Sbjct: 280 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 339
Query: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 340 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 392
Query: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 393 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 449
Query: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 450 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 501
Query: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 502 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 557
Query: 422 INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473
IN +GLI A + + Y L V + A+ T+ IE N P F
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
Query: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532
Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG+++ +
Sbjct: 618 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 674
Query: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 675 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ V A D D + GN F + + + K N +++ + L
Sbjct: 732 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 788
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ ATDG +H + S+ + LA K+L
Sbjct: 789 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 810
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 811 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 863
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 864 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 923
Query: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 924 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 982
Query: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 983 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1039
Query: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1095
Query: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 1096 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1153
Query: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1154 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1213
Query: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1214 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1270
Score = 145 bits (367), Expect = 7e-34
Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
Query: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 426 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 484 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536
G ++ IL G + + + G++ A + Y L VQA D+ P + ++
Sbjct: 542 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594
+ + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++ + +
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 659
Query: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
+F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 660 VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 694
Score = 102 bits (253), Expect = 1e-20
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 505 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 558
Query: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 559 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 670
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 671 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
Query: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 725 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 780
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 781 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 833
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 894 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 951
Query: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 952 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 1010
Query: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 1011 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1067
Query: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1116
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
+ +V SKS N +++ N P F K F
Sbjct: 1117 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1150
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 1151 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1207
Query: 787 M 787
M
Sbjct: 1208 M 1208
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 1058 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1115
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1230
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1231 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1269
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 324 bits (830), Expect = 1e-87
Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 104 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 163
Query: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 164 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 223
Query: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 224 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 280
Query: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
++Y + T + AID D + + Y I+ G
Sbjct: 281 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 340
Query: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 341 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 392
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
E+ ++++ Y +S P + + L +
Sbjct: 393 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 425
Query: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 426 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 484
Query: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 485 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 542
Query: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S
Sbjct: 543 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 602
Query: 919 VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
+ T+ + + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N
Sbjct: 603 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 659
Query: 978 -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
D F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+
Sbjct: 660 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 717
Query: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
N + PY P V + N+ +G QV A D D+G +G++ YS+ + + L R +
Sbjct: 718 NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 771
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
+G I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y
Sbjct: 772 -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 830
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+V EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD
Sbjct: 831 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 887
Query: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267
E Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+
Sbjct: 888 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 943
Query: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322
+G PI +A D D P + + Y + D F ++ +G V +R
Sbjct: 944 -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1002
Query: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
I L + A D+G P SS+A + I + P IP E + V E +
Sbjct: 1003 PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1059
Query: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
VGV+S N + + IV GN + F G I + PLD E R+ Y + V+ D
Sbjct: 1060 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1118
Query: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
V + +V+I++ D N++ P F + Y +SED T +L+++ATD+D
Sbjct: 1119 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1178
Query: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
+ I I K F ++ TG++ TA + + ++ D
Sbjct: 1179 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1238
Query: 1548 NLARVIVNVEDANDHSPYFTN 1568
A V+V+V + D +N
Sbjct: 1239 GKADVLVSVVNQLDMQVIVSN 1259
Score = 311 bits (796), Expect = 1e-83
Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 254
Query: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
D I YS+ + P + N+ + +KA
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
Query: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 375 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
Query: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 434 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 490
Query: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 491 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 550
Query: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909
Y + +Q + F I+ TG I+ ++ T+ +V A+D A +S
Sbjct: 551 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 605
Query: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968
V + V N+ +P F Q +Y + E+ G V+ L DR+ + +Y I G+
Sbjct: 606 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 661
Query: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026
P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+
Sbjct: 662 PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 719
Query: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
PV D L + +N + +V A D D G NG + YSL N F +G +
Sbjct: 720 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 777
Query: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144
T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y V EN
Sbjct: 778 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 837
Query: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199
+ +++A D D+G N V Y + + F++ +G + L + LD E Q++
Sbjct: 838 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 895
Query: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
S V A D G + TVT+ V D+ND PPVF +R Y V D GT + V+
Sbjct: 896 SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 954
Query: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314
A D R + Q F++ +G + L+ E F LVV A
Sbjct: 955 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 1014
Query: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373
D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A + N
Sbjct: 1015 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1069
Query: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426
I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA + +P+
Sbjct: 1070 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1129
Query: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ + I
Sbjct: 1130 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1189
Query: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
+ +E E FV++ + G++++A++F + + V A D
Sbjct: 1190 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1231
Score = 310 bits (795), Expect = 2e-83
Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
Query: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 379
Query: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 380 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
Query: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 436 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 493
Query: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 494 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 553
Query: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245
G Q F IN TGLIT ++ + L V D P ++ S V ++VL
Sbjct: 554 LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 611
Query: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304
N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +G+ F
Sbjct: 612 PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 666
Query: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362
+ TG+++ K S D IL I A D GRP +STA ++I +P+ F
Sbjct: 667 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 722
Query: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
D P+ N +V+E + + V + P N + + + GNF++ F G+I
Sbjct: 723 D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 778
Query: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V + E++
Sbjct: 779 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 838
Query: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534
T ILQIEA D D +SY + S F + P TG L LD+EA
Sbjct: 839 AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 895
Query: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
+I + F + A V V V+D ND+ P F+ +Y+ V A G+ + V A
Sbjct: 896 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 955
Query: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641
D D G A + ++ ++F++E V+ + + +EP TT+ F L +
Sbjct: 956 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 1011
Query: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699
D G P MS++A V+I V + P+F ++Y+ V+E GT V +ISA +
Sbjct: 1012 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1070
Query: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752
+++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1071 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1130
Query: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810
A V I+I DEN++ PVF Y G +SE A + S L ++ATD D+ ++
Sbjct: 1131 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1183
Query: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
+ Y+++ K+ F V++ TG I+T + ++F F V D L+ ++ V
Sbjct: 1184 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1243
Query: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
+++++V N P + + + + +L YV ++
Sbjct: 1244 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1284
Score = 271 bits (694), Expect = 8e-72
Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 254
Query: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292
L V + ++ P VP + + P TY +VT + +D
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
N + S SI+ G P D E + E D F ++L ++
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 371
Query: 347 AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
A+ D G P A ++I + F Y I E +P G
Sbjct: 372 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
Query: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 430 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 488
Query: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 489 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 548
Query: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565
ITY I F+IN+ TG+I+ ++ Y V+A+D P R S V
Sbjct: 549 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 607
Query: 566 IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624
I + N+ S P F ++ IS VG + + A D E + + Y I +G+ F
Sbjct: 608 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 666
Query: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683
L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 667 NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 713
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P FD P +++V E+ A
Sbjct: 714 ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 739
Query: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
+ ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y L +
Sbjct: 740 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 796
Query: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N
Sbjct: 797 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 856
Query: 864 GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917
V+Y + + + FA++ TG + + LD E+ +A+ + +EA D G
Sbjct: 857 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 912
Query: 918 SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975
+ T+ V + D+ND P F Y V D GT I + E DP +VRY
Sbjct: 913 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 971
Query: 976 VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
V+D FE+++ SG + L+ E + L V A D G PV +SS + V++
Sbjct: 972 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1030
Query: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
V LH P F V E + GT V ++A + + I YSI G+
Sbjct: 1031 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1080
Query: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139
F I++ +GVI LD ET SY L V A VV +T +VYIE++
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140
Query: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
D N++ P+ + Y V E++ SV++++A D D+ + + YR+ + F
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200
Query: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+ TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1201 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252
Score = 271 bits (694), Expect = 8e-72
Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)
Query: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
SD + YSIL G F M ++ ++L + + L +
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
Query: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 378 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
Query: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580
T + +ND+ F + G + + +DRE + + + A DG
Sbjct: 438 IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 494
Query: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
+ V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N ITY +
Sbjct: 495 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 554
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698
A D + I+ G + + + V+A D P ++S+ VYI V
Sbjct: 555 VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 610
Query: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755
LPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P+ +
Sbjct: 611 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 665
Query: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
F + + TG + L K LDRE++ + + A+ + D T V+I V D+NDN PVF+
Sbjct: 666 FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 723
Query: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
+ + + QV+A D D G NGQV YSL + + F I SN G I
Sbjct: 724 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 776
Query: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
T L+ E + VVA+D G ST ++++V DI+DN+PVF Y V+E
Sbjct: 777 YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 835
Query: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993
+ P G + + D D+ VSY I + FAL E + + R LD E
Sbjct: 836 NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 890
Query: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
E I FL + A D ++ T A V V V D+ND PV + Y ++ D
Sbjct: 891 PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 948
Query: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
I V A+DAD +RY + + S F ++ +SG + T L+ E ++
Sbjct: 949 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1008
Query: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
L+ A D G S+ + IL P F+ + Y ATK + V +
Sbjct: 1009 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1065
Query: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212
IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 1066 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1125
Query: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD G + +
Sbjct: 1126 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1185
Query: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329
Y LI ++GK F + TG I + + F V A D LS A V +
Sbjct: 1186 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1245
Query: 3330 NLTDVND 3336
++ + D
Sbjct: 1246 SVVNQLD 1252
Score = 261 bits (668), Expect = 9e-69
Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 86 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 140
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 141 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 200
Query: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
+ D EI D +++ + N N+ + T + V
Sbjct: 201 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 260
Query: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
+DG L P+++ VL P T +P + I I +
Sbjct: 261 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
Query: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 316 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 369
Query: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 370 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 430 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 489
Query: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 490 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 545
Query: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012
N +++Y I G +G F + ++ + + ++ Y L + A D +
Sbjct: 546 NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 602
Query: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069
V + V N+ SP Q+ Y+ + E + ++L + A D + S I Y++
Sbjct: 603 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 659
Query: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128
G F L +G L LDRE Y L+ A+DG + +++++ DVNDN
Sbjct: 660 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 719
Query: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185
PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F I +S+G
Sbjct: 720 PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 774
Query: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF Y V V
Sbjct: 775 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 833
Query: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304
E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+ LDYE
Sbjct: 834 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 891
Query: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
+VEA D +ATV + + D+ND PP FS+ +Y +++ DA+ G +
Sbjct: 892 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 951
Query: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416
+ AED D P ++ + + + + F V+ G V + L+ E + + L+V
Sbjct: 952 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 1011
Query: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475
A D G P MSS+ATV I + + P FT Y + E GT + + +
Sbjct: 1012 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1070
Query: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527
+SI+SGNEE+ F + + G++ + YVL VQA +
Sbjct: 1071 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1125
Query: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585
P + + + + + +E+ H P ED + ++ ATD+D Y V+
Sbjct: 1126 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1185
Query: 3586 FAL----KSEQKSLFKVNSHDGKI 3605
+ L E K F V ++ G I
Sbjct: 1186 YRLIIPPIKEGKEGFVVETYTGLI 1209
Score = 259 bits (662), Expect = 4e-68
Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 79 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 133
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 134 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 191
Query: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 192 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 251
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 252 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 309
Query: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 310 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 368
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 369 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 428
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 429 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 487
Query: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 488 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 543
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN P +++S
Sbjct: 544 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 602
Query: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400
++IE + PP + P F + Y+ + E+ RV ++ + + + + I G
Sbjct: 603 ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458
+ F+ + G + + K LD E Y + + +DG + V I V D NDN P
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
F P + E+ + + Q++ATD D ++ VH S+ + + FRI S G
Sbjct: 721 VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 774
Query: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
+YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN Y V
Sbjct: 775 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 834
Query: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630
E+ G+ +LQ+ A D D G N Y I + + F + P G +++ + PD
Sbjct: 835 ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 892
Query: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690
F++ PP AT V + V ++ P F + Y+ V + GT +
Sbjct: 893 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 950
Query: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740
+ A + S + Y V D IF + SG + T+ L+ E T+ ++L+
Sbjct: 951 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1010
Query: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797
+ A + M+S+ATV I ++ + P F +Y +SE A ++V + + +
Sbjct: 1011 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1068
Query: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857
N +VY IV + F +++ TG I LD+ET + V DS
Sbjct: 1069 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1117
Query: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911
L + + +V IE+ D N++PPVF + + + + VL+V ATD D
Sbjct: 1118 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1177
Query: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
+ + Y L+ EG + F++++ +G++ + +N+ + ++ V +D
Sbjct: 1178 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1231
Score = 256 bits (655), Expect = 3e-67
Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
Query: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 378 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 407
Query: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Y L + + DS + ++ L KD +++ D
Sbjct: 408 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 444
Query: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
LH + Y++ + T IT+ T
Sbjct: 445 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 470
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 471 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 527
Query: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + + Y +
Sbjct: 528 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 586
Query: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
T+ A D P S+ T + N++ P F + Y+ ++E +R+ +L++ AT
Sbjct: 587 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 646
Query: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271
EG I Y I +GDP + FN+ TG+L + LD E T Y L I ASD +
Sbjct: 647 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 706
Query: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
TV+++V DVNDN P+FD P + + E + V QV + D D+ N VHY +
Sbjct: 707 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 761
Query: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
N + F I +S+G I TA L+ E+ + L V + D S + + I + D++D
Sbjct: 762 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 819
Query: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
N PVF Y V E P G + ++A D D + Y I S + F + +G
Sbjct: 820 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 877
Query: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502
++L P +++ F A V + V N Y P FS+ Y
Sbjct: 878 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 937
Query: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556
V + GT + V A D DP ++ Y + + + F + + +G+VIT
Sbjct: 938 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 997
Query: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
L+ E + V A D G ++ TV+++V+ + P+F EYR +++
Sbjct: 998 NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1054
Query: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
+G +V + A N I YS+ S + D I+ G + G + T
Sbjct: 1055 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1107
Query: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
V+A + +P K + VYI + P F + Y ++ED + ++
Sbjct: 1108 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1167
Query: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
V ++ +S + E +G FV+E TG IK F F
Sbjct: 1168 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1225
Query: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
+V AT K D++ +V +D++V+ N + E T D + E +P
Sbjct: 1226 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1285
Score = 253 bits (647), Expect = 2e-66
Identities = 285/1097 (25%), Positives = 479/1097 (43%), Gaps = 114/1097 (10%)
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698
P+ A A + I + +N P F YQ + E+ +G TS + I A+ +
Sbjct: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
Query: 1699 STLIYEVKD-------GDINGIFTINPYSGV---ITTQKALDYERTSSYQLIIQATNMAG 1748
I + KD D +FT+ +G+ +T + +D E +Y I A +
Sbjct: 437 D--IEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 493
Query: 1749 MASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNR 1807
+ VNIQ++D NDN P F Y + ++ P +S+++ + A DAD
Sbjct: 494 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGS 545
Query: 1808 NALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
N + Y+I+ A+ F ++ +TG I ++ + V D+ P S
Sbjct: 546 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 604
Query: 1868 EVNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS 1926
V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++ G
Sbjct: 605 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGD 661
Query: 1927 LDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLH 1981
F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D+
Sbjct: 662 PQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 721
Query: 1982 FTQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
F S E N + +V + +N + YS+ N N F+I S + T
Sbjct: 722 FDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--T 778
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+ +
Sbjct: 779 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 838
Query: 2099 PGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIE 2153
GT I Q+ A D D G N + F ++P +G + L EAF ++I
Sbjct: 839 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 898
Query: 2154 YGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSP 2213
+ V G P +V + + +N PVF K Y V D TPI ++ A
Sbjct: 899 FLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 958
Query: 2214 EGQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDAL 2264
+ G + Y + D P F ++ D+G + L+ E T+ +KL + A D
Sbjct: 959 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 1018
Query: 2265 TGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHY 2324
+ TV +LV + P + +SE + GT +V + + + N+ + Y
Sbjct: 1019 PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVY 1074
Query: 2325 QIVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSE 2377
IV N D F I++ +G+I LD+E VQ +L+V + PS S+
Sbjct: 1075 SIVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1132
Query: 2378 VLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL--- 2434
V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y ++
Sbjct: 1133 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1192
Query: 2435 SGNDRTSFLMDSKSGVI 2451
+ F++++ +G+I
Sbjct: 1193 IKEGKEGFVVETYTGLI 1209
Score = 238 bits (607), Expect = 1e-61
Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)
Query: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 161 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 220
Query: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 221 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 280
Query: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 281 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 340
Query: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 341 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 398
Query: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 399 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 451
Query: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 452 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 508
Query: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 509 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 565
Query: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
+G+IT A ++ +Y LTV A D S VYIEV N+ +P +
Sbjct: 566 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 625
Query: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++ T + L
Sbjct: 626 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 681
Query: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271
DRE + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 682 DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 740
Query: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330
+ + A D D G N ++ YS+ GN + F I + ++ K Y L +
Sbjct: 741 ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 795
Query: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388
A D + ST L I+ + SP+ F N +TV+ + + ++ ++
Sbjct: 796 ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 848
Query: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438
+ L + I F G + + + LD E Q + VE D G
Sbjct: 849 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 908
Query: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495
T +A V +K D ND P FS+ Y ++ D + T I + A D D +
Sbjct: 909 TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 966
Query: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
V +D + F ++ +G + T L+ E L ++ D P + A
Sbjct: 967 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 1026
Query: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610
V + V + P FT Y V E A G+ V ++A N ++Y+I +GN
Sbjct: 1027 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1081
Query: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663
+ F I + G+I + D T +VL ++ + + P S TA V I +
Sbjct: 1082 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1141
Query: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713
+N P F K Y V+E+ + TSV+ + A + T +I +K+G
Sbjct: 1142 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1199
Query: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1200 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252
Score = 186 bits (473), Expect = 4e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 358 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 417
Query: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 418 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 477
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 478 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 528
Query: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 529 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 580
Query: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 581 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 640
Query: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 641 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 700
Query: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 701 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 755
Query: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 756 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 811
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 812 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 871
Query: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
L+P +G L L +SL + + + A D P ++V+
Sbjct: 872 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 920
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P F K + V D G
Sbjct: 921 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 948
Query: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 949 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1008
Query: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 1009 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1067
Query: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 1068 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1120
Query: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 1121 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1180
Query: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 1181 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1240
Query: 1017 RPVSLSSVSFVEVEVVDVN 1035
V +S V+ ++++V+ N
Sbjct: 1241 ADVLVSVVNQLDMQVIVSN 1259
Score = 174 bits (441), Expect = 2e-42
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 474 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 532
Query: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 533 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 592
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
N + + +Y+ + N +P + + V ++
Sbjct: 593 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 649
Query: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 650 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 702
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 703 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 762
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 763 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 821
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 822 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 879
Query: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 880 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 937
Query: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 938 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 989
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 990 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1031
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L G + P F + V E G + I A + N
Sbjct: 1032 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1071
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 1072 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1131
Query: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 1132 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1191
Query: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 1192 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1251
Query: 929 VNDCSPAFIPSSYSVKVLEDL 949
+ +P + K +EDL
Sbjct: 1252 DMQVIVSNVPPTLVEKKIEDL 1272
Score = 168 bits (426), Expect = 1e-40
Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 225 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 284
Query: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
TY I E TP + VT A D D G Y + F
Sbjct: 285 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 344
Query: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 345 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 397
Query: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 398 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 454
Query: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 455 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 506
Query: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 507 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 562
Query: 422 INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473
IN +GLI A + + Y L V + A+ T+ IE N P F
Sbjct: 563 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 622
Query: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532
Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG+++ +
Sbjct: 623 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 679
Query: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 680 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 736
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ V A D D + GN F + + + K N +++ + L
Sbjct: 737 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 793
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ ATDG +H + S+ + LA K+L
Sbjct: 794 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 815
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 816 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 868
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 869 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 928
Query: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 929 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 987
Query: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 988 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1044
Query: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 1045 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1100
Query: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 1101 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1158
Query: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1159 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1218
Query: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1219 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1275
Score = 145 bits (367), Expect = 7e-34
Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 131 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 190
Query: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 191 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
Query: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
Query: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 370
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 371 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 430
Query: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 431 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 488
Query: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 489 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 546
Query: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536
G ++ IL G + + + G++ A + Y L VQA D+ P + ++
Sbjct: 547 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 605
Query: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594
+ + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++ + +
Sbjct: 606 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 664
Query: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
+F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 665 VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 699
Score = 102 bits (253), Expect = 1e-20
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 510 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 563
Query: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 564 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 619
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 620 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 675
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 676 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 729
Query: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 730 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 785
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 786 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 838
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 839 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 898
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 899 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 956
Query: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 957 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 1015
Query: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 1016 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1072
Query: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 1073 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1121
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
+ +V SKS N +++ N P F K F
Sbjct: 1122 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1155
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 1156 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1212
Query: 787 M 787
M
Sbjct: 1213 M 1213
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 1063 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1120
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1121 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1180
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1181 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1235
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1236 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1274
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 323 bits (828), Expect = 2e-87
Identities = 332/1217 (27%), Positives = 545/1217 (44%), Gaps = 128/1217 (10%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 104 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 163
Query: 484 SVPVGTSVLTV-----SASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 164 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 223
Query: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIG------------------NVNDN 574
L++E Y I++A+D T+ + N D
Sbjct: 224 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282
Query: 575 SPLFEKVACQGVISYDFPVGGHITA-VSAIDID-------ELELVKYKIISGNELG---F 623
PL + A + + + +T + AID D + + Y I+ G F
Sbjct: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342
Query: 624 FYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
F+++P + L L + + + + ++ +G L ++I +L S F+
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+ + E + A + LNL L ++++ + PS V K+
Sbjct: 403 PSYQ--GYILESAPVGATISDSLNLTSP-LRIVALDKD---IEDVPPSGVPTKDPE---- 452
Query: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
L + D S +FT++ T L +L P+DRE Y +IT
Sbjct: 453 --LHLFLNDYTS------VFTVTQTGI---------TRYLTLLQPVDREEQQTYTFSITA 495
Query: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
+D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D GSN
Sbjct: 496 FD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 553
Query: 864 GEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTL 922
GE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S+ T+
Sbjct: 554 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 613
Query: 923 KVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN-DYN 980
+ + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N D
Sbjct: 614 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQ 670
Query: 981 GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNEN--L 1038
F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+N +
Sbjct: 671 RVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPV 728
Query: 1039 HTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESG 1098
PY P V + N+ +G QV A D D+G +G++ YS+ + + L R + +G
Sbjct: 729 FDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT---SNG 781
Query: 1099 VITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVM 1158
I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y +V
Sbjct: 782 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 841
Query: 1159 ENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDRE--- 1215
EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD E
Sbjct: 842 ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFP 898
Query: 1216 -QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERDRKKR 1271
Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+ +
Sbjct: 899 DQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD---AVK 953
Query: 1272 GEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAGSYDI 1326
G PI +A D D P + + Y + D F ++ +G V +R I
Sbjct: 954 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1013
Query: 1327 --LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVV 1384
L + A D+G P SS+A + I + P IP E + V E +VGV+
Sbjct: 1014 FKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTMVGVI 1070
Query: 1385 SVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAV- 1443
S N + + IV GN + F G I + PLD E R+ Y + V+ D V +
Sbjct: 1071 SAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLA 1129
Query: 1444 ----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKL 1493
+V+I++ D N++ P F + Y +SED T +L+++ATD+D +
Sbjct: 1130 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1189
Query: 1494 SYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
I I K F ++ TG++ TA + + ++ D A
Sbjct: 1190 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1249
Query: 1552 VIVNVEDANDHSPYFTN 1568
V+V+V + D +N
Sbjct: 1250 VLVSVVNQLDMQVIVSN 1266
Score = 311 bits (798), Expect = 7e-84
Identities = 319/1129 (28%), Positives = 505/1129 (44%), Gaps = 111/1129 (9%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 254
Query: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
D I YS+ + P + N+ + +KA
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 374
Query: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPS------ 2735
D G P+ + ++I +L P FT Y I E +G+T+ L S
Sbjct: 375 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 433
Query: 2736 -----QNVWFSTVNGERPE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKV 2783
++V S V + PE N+ +F + Q T + L + +DRE + F +
Sbjct: 434 LDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493
Query: 2784 AATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDW 2843
A D V V V+I+V+D NDN P F SYD + M G + Q+ A+D D
Sbjct: 494 TA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 550
Query: 2844 GANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AF 2902
G+NG++TY + +Q + F I+ TG I+ ++ T+ +V A+D A
Sbjct: 551 GSNGEITYEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 605
Query: 2903 SLSSTALVSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVS 2961
+S V + V N+ +P F Q +Y + E+ G V+ L DR+ + +
Sbjct: 606 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----T 661
Query: 2962 YHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSV 3019
Y I G+P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V
Sbjct: 662 YAIENGDPQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 719
Query: 3020 SDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLD 3079
+DVNDN+PV D L + +N + +V A D D G NG + YSL N F
Sbjct: 720 TDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRI 777
Query: 3080 PESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYN 3137
+G + T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y
Sbjct: 778 TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 837
Query: 3138 TCVYENTATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE 3196
V EN + +++A D D+G N V Y + + F++ +G + L + LD E
Sbjct: 838 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 895
Query: 3197 ----QQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPG 3252
Q++S V A D G + TVT+ V D+ND PPVF +R Y V D G
Sbjct: 896 AFPDQEASITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 954
Query: 3253 TQVLAVFATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRF 3307
T + V+A D R + Q F++ +G + L+ E F
Sbjct: 955 TPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIF 1014
Query: 3308 YLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAE 3366
LVV A D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A
Sbjct: 1015 KLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAA 1073
Query: 3367 DVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------V 3419
+ N I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA
Sbjct: 1074 AI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1129
Query: 3420 DSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNG 3479
+ +P+ S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ +
Sbjct: 1130 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1189
Query: 3480 PPFSFSILSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
I+ +E E FV++ + G++++A++F + + V A D
Sbjct: 1190 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1238
Score = 308 bits (789), Expect = 8e-83
Identities = 329/1188 (27%), Positives = 543/1188 (45%), Gaps = 140/1188 (11%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 199
Query: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 200 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 259
Query: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 260 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 319
Query: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 320 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 379
Query: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 380 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 435
Query: 1070 ED------SG---RDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYA 1120
+D SG +D E+ + D + + + + +T +DRE +Y ++ A
Sbjct: 436 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 495
Query: 1121 TDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSN 1180
D V + V I+V D NDN P E Y V + SVIQ+ A D D SN
Sbjct: 496 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 553
Query: 1181 EKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STI 1238
++TY I G Q F IN TGLIT ++ + L V D P ++ S
Sbjct: 554 GEITYEILVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSIC 611
Query: 1239 WVVVQVLDENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVD 1297
V ++VL N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +
Sbjct: 612 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIEN 666
Query: 1298 GNDDGKFFIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPP 1355
G+ F + TG+++ K S D IL I A D GRP +STA ++I
Sbjct: 667 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 725
Query: 1356 SPIPLTFDEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEK 1410
+P+ FD P+ N +V+E + + V + P N + + + GNF++ F
Sbjct: 726 APV---FD-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 779
Query: 1411 GVGTIVIAKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDV 1467
G+I A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V
Sbjct: 780 N-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 838
Query: 1468 TISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHE 1527
+ E++ T ILQIEA D D +SY + S F + P TG L LD+E
Sbjct: 839 LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYE 895
Query: 1528 AQDKHILNIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGS 1583
A +I + F + A V V V+D ND+ P F+ +Y+ V A G+
Sbjct: 896 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 955
Query: 1584 AVLQVTALDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTM 1634
+ V A D D G A + ++ ++F++E V+ + + +EP TT+
Sbjct: 956 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI 1013
Query: 1635 GQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILI 1693
F L + D G P MS++A V+I V + P+F ++Y+ V+E GT V +I
Sbjct: 1014 --FKLVVVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVI 1070
Query: 1694 SAIS-QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN 1752
SA + +++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1071 SAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLAN 1130
Query: 1753 ---------ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDA 1803
A V I+I DEN++ PVF Y G +SE A + S L ++ATD
Sbjct: 1131 LRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDK 1183
Query: 1804 DSNRNALLVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQ 1860
D+ +++ Y+++ K+ F V++ TG I+T + ++F F V D
Sbjct: 1184 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1243
Query: 1861 LTAESPV------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
L+ ++ V +++++V N P + + + + +L YV ++
Sbjct: 1244 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1291
Score = 270 bits (691), Expect = 2e-71
Identities = 330/1200 (27%), Positives = 515/1200 (42%), Gaps = 173/1200 (14%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 254
Query: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TY---------------AVVT--VDDLDD 292
L V + ++ P VP + + P TY +VT + +D
Sbjct: 255 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 314
Query: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
N + S SI+ G P D E + E D F ++L ++
Sbjct: 315 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 371
Query: 347 A-KDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVA--------- 396
A +D G P A ++I + F Y I E +P G ++
Sbjct: 372 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
Query: 397 -IVKLSPEPIDVEYKLSPGED-AVYFKINPRSGL-----------IVTARPLNTVKKEVY 443
IV L + DV P +D ++ +N + + + +P++ +++ Y
Sbjct: 430 RIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTY 489
Query: 444 KLEVTNKEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKD 500
+T +G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D
Sbjct: 490 TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 549
Query: 501 KGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHE 559
+G NG ITY I F+IN+ TG+I+ ++ Y V+A+D P R
Sbjct: 550 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRN 608
Query: 560 SEVNVTIRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISG 618
S V I + N+ S P F ++ IS VG + + A D E + + Y I +G
Sbjct: 609 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENG 667
Query: 619 NELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVS 677
+ F L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 668 DPQRVFNLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----- 720
Query: 678 SKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKE 737
+N P FD P +++V E
Sbjct: 721 ---------------------------------------DVNDNAPVFDPYLPRNLSVVE 741
Query: 738 DLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLY 797
+ A + ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y
Sbjct: 742 E-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYY 797
Query: 798 LLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARD 857
L + D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D
Sbjct: 798 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 857
Query: 858 KDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAE 911
DLG+N V+Y + + + FA++ TG + + LD E+ +A+ + +EA D
Sbjct: 858 VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--I 913
Query: 912 SGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGG 969
G + T+ V + D+ND P F Y V D GT I + E DP
Sbjct: 914 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 973
Query: 970 QVRYSLVNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSV 1024
+VRY V+D FE+++ SG + L+ E + L V A D G PV +SS
Sbjct: 974 RVRYR-VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSS 1031
Query: 1025 SFVEVEVVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQY 1080
+ V++ V LH P F V E + GT V ++A + + I Y
Sbjct: 1032 ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVY 1081
Query: 1081 SIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIE 1133
SI G+ F I++ +GVI LD ET SY L V A VV +T +
Sbjct: 1082 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1141
Query: 1134 VYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSG 1190
VYIE++D N++ P+ + Y V E++ SV++++A D D+ + + YR+
Sbjct: 1142 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK 1201
Query: 1191 NPQNFFAINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+ F + TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1202 EGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
Score = 268 bits (685), Expect = 9e-71
Identities = 311/1154 (26%), Positives = 492/1154 (42%), Gaps = 122/1154 (10%)
Query: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
SD + YSIL G F M ++ ++L + + L +
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 377
Query: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 378 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 437
Query: 2525 --------PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVR 2573
T + +ND+ F + G + + +DRE + + +
Sbjct: 438 IEDVPPSGVPTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSIT 494
Query: 2574 ALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANS 2633
A DG + V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N
Sbjct: 495 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 554
Query: 2634 RITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSL 2691
ITY + A D + I+ G + + + V+A D P ++S+
Sbjct: 555 EITYEILVGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI 610
Query: 2692 IPVYIHVLPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERP 2748
VYI VLPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P
Sbjct: 611 CTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-P 669
Query: 2749 ENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLN 2808
+ +F + + TG + L K LDRE++ + + A+ + D T V+I V D+N
Sbjct: 670 QR----VFNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVN 723
Query: 2809 DNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNI 2868
DN PVF+ + + + QV+A D D G NGQV YSL + + F I
Sbjct: 724 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRI 777
Query: 2869 DSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEV 2928
SN G I T L+ E + VVA+D G ST ++++V DI+DN+PVF
Sbjct: 778 TSN-GSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNST 835
Query: 2929 YRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKR 2988
Y V+E+ P G + + D D+ VSY I + FAL E + + R
Sbjct: 836 YTVLVEENLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLR 890
Query: 2989 PLDRE-----EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLP 3039
LD E E I FL + A D ++ T A V V V D+ND PV + Y ++
Sbjct: 891 SLDYEAFPDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVA 948
Query: 3040 EDIPSNKIILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDR 3093
D I V A+DAD +RY + + S F ++ +SG + T L+
Sbjct: 949 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 1008
Query: 3094 ERIPVYSLMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTR 3152
E ++ L+ A D G S+ + IL P F+ + Y ATK +
Sbjct: 1009 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVG 1068
Query: 3153 VQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD-- 3209
V + IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 1069 VISA---AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1125
Query: 3210 ----QSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDI 3265
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD
Sbjct: 1126 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1185
Query: 3266 GTNAEITY-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALS 3322
G + + Y LI ++GK F + TG I + + F V A D LS
Sbjct: 1186 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1245
Query: 3323 AVATVNINLTDVND 3336
A V +++ + D
Sbjct: 1246 GKADVLVSVVNQLD 1259
Score = 258 bits (658), Expect = 1e-67
Identities = 311/1171 (26%), Positives = 505/1171 (43%), Gaps = 136/1171 (11%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 86 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 140
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 141 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 200
Query: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
+ D EI D +++ + N N+ + T + V
Sbjct: 201 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 260
Query: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
+DG L P+++ VL P T +P + I I +
Sbjct: 261 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 315
Query: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 316 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 369
Query: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLT--------- 2834
I ++ + + + I++LD N+ P F SY I+E PVG ++
Sbjct: 370 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
Query: 2835 QVRAIDM---DWGANGQVTYSLHSDSQPEKVMEAFNIDSN--TGWISTLKDLDHETDPTF 2889
++ A+D D +G T F + T +++ L+ +D E T+
Sbjct: 430 RIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTY 489
Query: 2890 TFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTW 2949
TFS+ A D S +V+++V D NDN P F + Y V PG+ V L+
Sbjct: 490 TFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAV 546
Query: 2950 DRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLF 3009
D D N +++Y I G +G F + ++ + + ++ Y L + A D
Sbjct: 547 DADEGS-NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAP 602
Query: 3010 VTQ-----AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGY 3063
+ V + V N+ SP Q+ Y+ + E + ++L + A D + S
Sbjct: 603 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS--- 659
Query: 3064 IRYSL-YGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLIL 3121
I Y++ G F L +G L LDRE Y L+ A+DG + +++++
Sbjct: 660 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 719
Query: 3122 EDVNDNPPVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVF 3178
DVNDN PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F
Sbjct: 720 TDVNDNAPVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLF 775
Query: 3179 SIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFER 3238
I +S+G I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF
Sbjct: 776 RI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTN 833
Query: 3239 RDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEV 3298
Y V V E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+
Sbjct: 834 STYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRS 891
Query: 3299 LDYELC----KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDA 3354
LDYE +VEA D +ATV + + D+ND PP FS+ +Y +++ DA
Sbjct: 892 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 951
Query: 3355 LVGDSVILLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERV 3409
+ G + + AED D P ++ + + + + F V+ G V + L+ E
Sbjct: 952 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 1011
Query: 3410 SGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQL 3468
+ + L+V A D G P MSS+ATV I + + P FT Y + E GT + +
Sbjct: 1012 TIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVI 1070
Query: 3469 VVTDRDSFHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA---- 3523
+ +SI+SGNEE+ F + + G++ + YVL VQA
Sbjct: 1071 SAAAINQ-----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1125
Query: 3524 ---KDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM 3580
+ P + + + + + +E+ H P ED + ++ ATD+D
Sbjct: 1126 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1185
Query: 3581 --YDVLTFAL----KSEQKSLFKVNSHDGKI 3605
Y V+ + L E K F V ++ G I
Sbjct: 1186 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLI 1216
Score = 257 bits (656), Expect = 2e-67
Identities = 304/1203 (25%), Positives = 534/1203 (44%), Gaps = 145/1203 (12%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 79 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 133
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 134 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 191
Query: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 192 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 251
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 252 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 309
Query: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 310 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 368
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 369 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 428
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS----------RKLDREQQ 1217
++I A D D + + + +P+ +N T + T T + +DRE+Q
Sbjct: 429 LRIVALDKDIE--DVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQ 486
Query: 1218 AEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYR 1277
+ +T DG + + V +QV+D NDN P FPE Y + + R G+ + +
Sbjct: 487 QTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQ 542
Query: 1278 AFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNG 1335
A D DEG N EI+Y I+ G G F I+ TG+++ + G LT++A DN
Sbjct: 543 LTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 601
Query: 1336 RP--QKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTP 1392
P +++S ++IE + PP + P F + Y+ + E+ RV ++ + +
Sbjct: 602 PPAERRNSICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS 659
Query: 1393 LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKV 1450
+ + I G+ F+ + G + + K LD E Y + + +DG + V I V
Sbjct: 660 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 719
Query: 1451 LDNNDNGPEFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRK 1508
D NDN P F P + E+ + + Q++ATD D ++ VH S+ + +
Sbjct: 720 TDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NL 774
Query: 1509 FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTN 1568
FRI S G +YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN
Sbjct: 775 FRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 833
Query: 1569 PLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE 1628
Y V E+ G+ +LQ+ A D D G N Y I + + F + P G +++ +
Sbjct: 834 STYTVLVEENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRS 891
Query: 1629 ------PDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNE 1682
PD F++ PP AT V + V ++ P F + Y+ V
Sbjct: 892 LDYEAFPDQEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAP 949
Query: 1683 NVDIGTSVILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYE 1732
+ GT + + A + S + Y V D IF + SG + T+ L+ E
Sbjct: 950 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1009
Query: 1733 RTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVR 1789
T+ ++L++ A + M+S+ATV I ++ + P F +Y +SE A ++V
Sbjct: 1010 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVG 1068
Query: 1790 SLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHF 1849
+ + + N +VY IV + F +++ TG I LD+ET +
Sbjct: 1069 VISAAAI-----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVL 1117
Query: 1850 HVHVRDSGSPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVL 1903
V DS L + + +V IE+ D N++PPVF + + + + VL
Sbjct: 1118 RVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL 1176
Query: 1904 KVSATDPDSEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVK 1956
+V ATD D+ + Y L+ EG + F++++ +G++ + +N+ + ++ V
Sbjct: 1177 RVKATDKDTGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVI 1235
Query: 1957 VSD 1959
+D
Sbjct: 1236 ATD 1238
Score = 253 bits (645), Expect = 4e-66
Identities = 283/1101 (25%), Positives = 478/1101 (43%), Gaps = 115/1101 (10%)
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 196
Query: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 197 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 256
Query: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 257 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 316
Query: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 317 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 376
Query: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVI----LISAISQSTLIY 1703
P+ A A + I + +N P F YQ + E+ +G ++ L S + L
Sbjct: 377 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436
Query: 1704 EVKDGDINGIFT--------INPYSGVITTQKA-----------LDYERTSSYQLIIQAT 1744
+++D +G+ T +N Y+ V T + +D E +Y I A
Sbjct: 437 DIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 496
Query: 1745 NMAGMASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDA 1803
+ + VNIQ++D NDN P F Y + ++ P +S+++ + A DA
Sbjct: 497 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDA 548
Query: 1804 DSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTA 1863
D N + Y+I+ A+ F ++ +TG I ++ + V D+ P
Sbjct: 549 DEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 607
Query: 1864 ESPVEVNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSL 1922
S V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++
Sbjct: 608 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAI 664
Query: 1923 MEGSLDH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMD 1977
G F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D
Sbjct: 665 ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVND 724
Query: 1978 SGLHFTQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGV 2034
+ F S E N + +V + +N + YS+ N N F+I S +
Sbjct: 725 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSI 783
Query: 2035 IQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQ 2094
T V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+
Sbjct: 784 Y--TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 841
Query: 2095 VDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDL 2149
+ GT I Q+ A D D G N + F ++P +G + L EAF
Sbjct: 842 ENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE 901
Query: 2150 SNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSIN 2209
++I + V G P +V + + +N PVF K Y V D TPI ++
Sbjct: 902 ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 961
Query: 2210 ATSPEGQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA- 2260
A + G + Y + D P F ++ D+G + L+ E T+ +KL + A
Sbjct: 962 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 1021
Query: 2261 SDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNK 2320
D + TV +LV + P + +SE + GT +V + + + N+
Sbjct: 1022 DDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQ 1077
Query: 2321 MVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPS 2373
+ Y IV N D F I++ +G+I LD+E VQ +L+V + PS
Sbjct: 1078 SIVYSIVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1135
Query: 2374 LSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSI 2433
S+ V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y +
Sbjct: 1136 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1195
Query: 2434 L---SGNDRTSFLMDSKSGVI 2451
+ + F++++ +G+I
Sbjct: 1196 IIPPIKEGKEGFVVETYTGLI 1216
Score = 243 bits (619), Expect = 4e-63
Identities = 294/1124 (26%), Positives = 475/1124 (42%), Gaps = 177/1124 (15%)
Query: 289 DLDDGANGEIESV-SIVAGDPL--DQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTL 345
D+DDG NG+IE V DP D F E + I RK++++E Y + +
Sbjct: 183 DIDDGPNGQIEYVIQYNPDDPTSNDTF----EIPLMLTGNIVLRKRLNYED-KTRYFVII 237
Query: 346 QAKDK--------------------GSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSI 385
QA D+ G L V + N TRD P+ Y +I
Sbjct: 238 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN-TRDCRPL-----TYQAAI 291
Query: 386 SEFSPPGVVVAIVKLSP-EPIDVEYKLSPGEDAV----------------YFKINPRSGL 428
E P + I+ P + ID + + P D +F ++PR+
Sbjct: 292 PELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE 351
Query: 429 IVTARPLNTVKKEVYKLEVTNKEGD-----LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+ P+N + + L + ++ + A + I I D N+ +P F P Y Y+ E
Sbjct: 352 LSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILE 411
Query: 484 SVPVG---------TSVLTVSASDKDKGE---NGYITYSIASLNLLPFVINQFTGVISTT 531
S PVG TS L + A DKD + +G T L +N +T V + T
Sbjct: 412 SAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPE----LHLFLNDYTSVFTVT 467
Query: 532 -----------EELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEK 580
+ +D E + Y F + A D + V V I++ + NDN+P F +
Sbjct: 468 QTGITRYLTLLQPVDREEQ-QTYTFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPE 523
Query: 581 VACQGVISYDFPVGGHITAVSAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKS 638
++ + D G + ++A+D DE + Y+I+ G + G F +N +G++ +
Sbjct: 524 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPG 582
Query: 639 LTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLI 698
+ I +AL + A D A+ + +V
Sbjct: 583 V--EMIVGRTYALTVQAADNAPPAERRNSICTV--------------------------- 613
Query: 699 KAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFN 758
+++ N Q P + + E + VGA +L ++A D +
Sbjct: 614 -------------YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---G 657
Query: 759 GKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLT 818
+ + I +G+ FN+ TG L + +DRE TD Y+L IT D G P +S +
Sbjct: 658 DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 716
Query: 819 INVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ 875
I V D NDN+PVF D Y +++++E + QV+A D D G NG+V YS+
Sbjct: 717 IVVTDVNDNAPVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNN 773
Query: 876 QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPA 935
F I +S G +Y A +L+RE + Y L + A D A + S +TL + + D++D SP
Sbjct: 774 LFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRH--STLTLAIKVLDIDDNSPV 830
Query: 936 FIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRL 994
F S+Y+V V E+LP GT I +E D D LG V Y + + + F + +G + L
Sbjct: 831 FTNSTYTVLVEENLPAGTTILQIEAKDVD--LGANVSYRIRSPEVKHFFALHPFTGELSL 888
Query: 995 SKELDYE----KQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVG 1050
+ LDYE ++ V A D + ++ V V V D+N+ + P F G
Sbjct: 889 LRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMND--YPPVFSKRIYKG 945
Query: 1051 SVKENSRIGTSVLQVTARDEDSG--RDGEIQYSIRDGS---GLGRFSIDDESGVITAADI 1105
V ++ GT + V A D D ++Y + D F ++++SG +
Sbjct: 946 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 1005
Query: 1106 LDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDV 1165
L+ E + L V A D G + S+ V I V + T E P V E + K
Sbjct: 1006 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1065
Query: 1166 SVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHF---- 1221
V I A ++ N+ + Y I SGN ++ F IN TG+I LD E + +
Sbjct: 1066 MVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQ 1120
Query: 1222 ---LEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRA 1278
LEV + + K +T V +++ DEN++ P F +K Y + E R + R
Sbjct: 1121 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS--VLRV 1178
Query: 1279 FAFDRDEGPNAEISYS-IVDGNDDGK--FFIDPKTGMVSSRKQF 1319
A D+D G + ++Y I+ +GK F ++ TG++ + F
Sbjct: 1179 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1222
Score = 239 bits (609), Expect = 6e-62
Identities = 293/1190 (24%), Positives = 480/1190 (40%), Gaps = 151/1190 (12%)
Query: 1755 VNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVR---SLDNSPLVIRATDADSNRNALL 1811
V I + D NDN+P F Y +++E P+ + + S DN ATD D N +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG-----ATDIDDGPNGQI 192
Query: 1812 VYQIV----ESTAKKFFTVDSS-TGAIRTIANLDHETIAHFHFHVHVRDSGSP-QLTAES 1865
Y I + T+ F + TG I L++E + + D +
Sbjct: 193 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252
Query: 1866 PVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELT------ 1919
+ ++V D +D P+F V L+P L A P+ P EL
Sbjct: 253 TTTLTVDVLDGDDLGPMFLPCV-----LVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 307
Query: 1920 ---------------------YSLMEGSLDH----FLIDSNSGVLTIKN--NNLSKDHYM 1952
YS++ G+ + F + + L++ N +
Sbjct: 308 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 367
Query: 1953 LIVKVSDGKFYSTSMVTIMVKEAMDSGL---HFTQSFYSTSISEN---------NTNITK 2000
L++K + + E +D +FT Y I E+ + N+T
Sbjct: 368 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427
Query: 2001 VAIVNAV----------GNRLNEPLKYSILNPGNKFKIKSTSGVIQ--TTGVPFDREEQE 2048
+ A+ G +P + LN + +G+ + T P DREEQ+
Sbjct: 428 PLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 487
Query: 2049 LYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVT 2107
Y + A D ++ + V+V + + D NDN+P F + Y V D PG + Q+T
Sbjct: 488 TYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 544
Query: 2108 AIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKP 2166
A+D D+G NGE+TY +L G F IN +G + + + Y +T+ A D P
Sbjct: 545 AVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPP 603
Query: 2167 -----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGIIYI 2221
S+ T + N++ P F + Y+ ++E +R+ +L++ AT EG I Y
Sbjct: 604 AERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYA 663
Query: 2222 IIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVN 2281
I +GDP + FN+ TG+L + LD E T Y L I ASD + TV+++V DVN
Sbjct: 664 IENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 723
Query: 2282 DNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHI 2339
DN P+FD P + + E + V QV + D D+ N VHY + N + F I
Sbjct: 724 DNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRI 777
Query: 2340 DSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIY 2399
+S+G I TA L+ E+ + L V + D S + + I + D++DN PVF Y
Sbjct: 778 -TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 836
Query: 2400 ESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQ 2459
V E P G + ++A D D + Y I S + F + +G ++L
Sbjct: 837 TVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDY 894
Query: 2460 RMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG 2512
P +++ F A V + V N Y P FS+ Y V + G
Sbjct: 895 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 954
Query: 2513 TKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTERLDRENPLEG 2566
T + V A D DP ++ Y + + + F + + +G+VIT L+ E
Sbjct: 955 TPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT-- 1012
Query: 2567 DVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG-RGHLVTQVQ 2623
+ V A D G ++ TV+++V+ + P+F EYR +++ +G +V +
Sbjct: 1013 IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVIS 1071
Query: 2624 AIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKA--- 2680
A N I YS+ S + D I+ G + G + T V+A
Sbjct: 1072 AA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL 1124
Query: 2681 ----VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ 2736
+ +P K + VYI + P F + Y ++ED + ++V ++
Sbjct: 1125 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1184
Query: 2737 NVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPL-- 2789
+S + E +G FV+E TG IK F F+V AT
Sbjct: 1185 TGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1242
Query: 2790 ---DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
K D++ +V +D++V+ N + E T D + E +P
Sbjct: 1243 GLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1292
Score = 236 bits (602), Expect = 4e-61
Identities = 294/1140 (25%), Positives = 485/1140 (42%), Gaps = 151/1140 (13%)
Query: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 161 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 220
Query: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 221 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 280
Query: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 281 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 340
Query: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 341 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 398
Query: 935 AFIPSSYSVKVLEDLPVGTVI------------------------AWLETHDPDLGLGGQ 970
F SY +LE PVG I + + T DP+L L
Sbjct: 399 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHL--- 455
Query: 971 VRYSLVNDYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVE 1028
+NDY F + + + + L + +D E+QQ Y ++ A D V S V
Sbjct: 456 ----FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVN 508
Query: 1029 VEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGL 1088
++V+D N+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+
Sbjct: 509 IQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-Q 565
Query: 1089 GRFSIDDESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAP 1146
G F I+ +G+IT A ++ +Y LTV A D S VYIEV N+ +P
Sbjct: 566 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP 625
Query: 1147 LTSEPIYYPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLI 1205
+ Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++
Sbjct: 626 PRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL 682
Query: 1206 TTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLP 1264
T + LDRE + L +T +DG P ST V + V D NDN P F P + +
Sbjct: 683 -TLGKALDRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 740
Query: 1265 ERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGS 1323
E + + + A D D G N ++ YS+ GN + F I + ++ K
Sbjct: 741 EEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRD 795
Query: 1324 YDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIV 1381
Y L + A D + ST L I+ + SP+ F N +TV+ + +
Sbjct: 796 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGT 848
Query: 1382 GVVSVQPANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSV 1433
++ ++ + L + I F G + + + LD E Q + V
Sbjct: 849 TILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 908
Query: 1434 EVTD--GT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD 1488
E D GT +A V +K D ND P FS+ Y ++ D + T I + A D D
Sbjct: 909 EAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 966
Query: 1489 EKHKLSYTVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFP 1544
+ V +D + F ++ +G + T L+ E L ++ D P
Sbjct: 967 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1026
Query: 1545 YRRNLARVIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIY 1603
+ A V + V + P FT Y V E A G+ V ++A N ++Y
Sbjct: 1027 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVY 1081
Query: 1604 TIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAI 1656
+I +GN + F I + G+I + D T +VL ++ + + P S TA
Sbjct: 1082 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1141
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVK 1706
V I + +N P F K Y V+E+ + TSV+ + A + T +I +K
Sbjct: 1142 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK 1201
Query: 1707 DGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
+G F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1202 EGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1259
Score = 184 bits (466), Expect = 2e-45
Identities = 235/986 (23%), Positives = 420/986 (42%), Gaps = 144/986 (14%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 358 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 417
Query: 174 -------RTSVAQVTATDADI---------GSNGEFYYYFKNKVDLFSVHPT--SGVISL 215
TS ++ A D DI + E + + + +F+V T + ++L
Sbjct: 418 TISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTL 477
Query: 216 SGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-V 272
++ +E+ Y I A D GV + + V+I+ + N++ PT +++ V
Sbjct: 478 LQPVDREEQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDV 528
Query: 273 PFSLEKEPTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
+ P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 529 YVYTDMRPGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM- 585
Query: 331 QIDWESFPYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEF 388
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE
Sbjct: 586 -----IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 640
Query: 389 SPPGVVVAIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEV 447
G V+ ++ + D + Y + G+ F ++ +G++ + L+ + Y L +
Sbjct: 641 MRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 700
Query: 448 T----NKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASD 498
T +G A V I + D ND+ P++D Y+ ++ V V V A+D
Sbjct: 701 TASDGRPDGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATD 755
Query: 499 KDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRH 558
D G NG + YS+ + N L + + G I T +L+ E + Y +V A+D G+ +
Sbjct: 756 PDAGINGQVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPR 811
Query: 559 ESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISG 618
S + + I++ +++DNSP+F ++ + P G I + A D+D V Y+I S
Sbjct: 812 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSP 871
Query: 619 NELGFFYLNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKV 676
FF L+P +G L L +SL + + + A D P ++V+
Sbjct: 872 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---- 927
Query: 677 SSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVK 736
+N P F K + V
Sbjct: 928 --------------------------------------VKDMNDYPPVFSKRIYKGM-VA 948
Query: 737 EDLPVGANILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDR 791
D G I + A DAD +V + + D S F ++ ++G++ + ++
Sbjct: 949 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 1008
Query: 792 EHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGT 848
E T ++ L + +D G P SS + I V + P F Q+ Y V+ L + G
Sbjct: 1009 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMV 1067
Query: 849 EIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEA 906
+I A N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A
Sbjct: 1068 GVISAAA------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1121
Query: 907 RDKAESGQQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLET 960
D E V T KV+++ D N+ P F Y V ED + T + ++
Sbjct: 1122 -DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1180
Query: 961 HDPDLGLGGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD-- 1014
D D G + Y L + + F ++ +G I+ + ++ ++ V A D
Sbjct: 1181 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1240
Query: 1015 -KG----RPVSLSSVSFVEVEVVDVN 1035
KG V +S V+ ++++V+ N
Sbjct: 1241 GKGLSGKADVLVSVVNQLDMQVIVSN 1266
Score = 174 bits (441), Expect = 2e-42
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 481 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 539
Query: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 540 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 599
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
N + + +Y+ + N +P + + V ++
Sbjct: 600 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 656
Query: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 657 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 709
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 710 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 769
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 770 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 828
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 829 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 886
Query: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 887 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 944
Query: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 945 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 996
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 997 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1038
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L G + P F + V E G + I A + N
Sbjct: 1039 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1078
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 1079 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1138
Query: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 1139 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1198
Query: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 1199 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1258
Query: 929 VNDCSPAFIPSSYSVKVLEDL 949
+ +P + K +EDL
Sbjct: 1259 DMQVIVSNVPPTLVEKKIEDL 1279
Score = 166 bits (421), Expect = 4e-40
Identities = 278/1143 (24%), Positives = 463/1143 (40%), Gaps = 176/1143 (15%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 225 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 284
Query: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
TY I E TP + VT A D D G Y + F
Sbjct: 285 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 344
Query: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 345 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 397
Query: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDD----GANGEIESVSIVA 305
P + ++ + LE P A +V +D D++D G + + +
Sbjct: 398 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFL 457
Query: 306 GDPLDQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVY 363
D F + + G ++L + +R++ Y ++ A D G + + +
Sbjct: 458 NDYTSVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQ 510
Query: 364 IGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDA 417
+ + D P F + YDV + PG ++++L+ D + Y++ G
Sbjct: 511 VMD-ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG 566
Query: 418 VYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHT 469
F IN +GLI A + + Y L V + A+ T+ IE N
Sbjct: 567 -DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP 625
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVI 528
P F Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG++
Sbjct: 626 PRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGIL 682
Query: 529 STTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVIS 588
+ + LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + +
Sbjct: 683 TLGKALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSV 739
Query: 589 YDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGN 648
+ + V A D D + GN F + + + K N +++
Sbjct: 740 VEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-Y 796
Query: 649 FALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNL 708
+ L + ATDG +H + S+ + LA K+L
Sbjct: 797 YELVVVATDG------------AVHPRHSTLT-----------LAIKVL----------- 822
Query: 709 EDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDG 768
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 823 --------DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP 871
Query: 769 NTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDA 824
F + TG+L +L +D E +IT +D+ +T+ V+D
Sbjct: 872 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDM 931
Query: 825 NDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------Q 876
ND PVF + Y + + GT I V A D D V Y V D Q
Sbjct: 932 NDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASI 990
Query: 877 FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAF 936
F + +G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 991 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRF 1047
Query: 937 IPSSYSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRL 994
Y + +L GT++ + + + YS+V+ + F I+ +G I +
Sbjct: 1048 TQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYV 1103
Query: 995 SKELDYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV 1048
+ LDYE + Y L V+A R S S+ + V +E+ D EN H P F
Sbjct: 1104 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFY 1161
Query: 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADI 1105
+G V E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1162 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1221
Query: 1106 LDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDV 1165
+ V ATD L +V + V + D + S P ++E +D+
Sbjct: 1222 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDL 1279
Query: 1166 SVI 1168
+ I
Sbjct: 1280 TEI 1282
Score = 141 bits (356), Expect = 1e-32
Identities = 142/581 (24%), Positives = 262/581 (45%), Gaps = 69/581 (11%)
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 131 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 190
Query: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 191 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
Query: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
Query: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 370
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 371 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 430
Query: 3361 ILLIAEDVDSQPNGQI-----HFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYS 3413
I+ + +D++ P + + D + FTV + + + + +DRE Y+
Sbjct: 431 IVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 490
Query: 3414 LLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDR 3473
+ A D G+ S VNI + D NDN+P F +Y + + G S++QL D
Sbjct: 491 FSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 548
Query: 3474 DSFHNGPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVS 3533
D NG ++ IL G + + + G++ A + Y L VQA D+ P +
Sbjct: 549 DEGSNGE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 607
Query: 3534 HTY--IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS 3590
++ + + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++
Sbjct: 608 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIEN 666
Query: 3591 -EQKSLFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
+ + +F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 667 GDPQRVFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 706
Score = 102 bits (253), Expect = 1e-20
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 517 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 570
Query: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 571 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 626
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 627 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 682
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 683 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 736
Query: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 737 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 792
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 793 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 845
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 846 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 905
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 906 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 963
Query: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 964 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 1022
Query: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 1023 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1079
Query: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 1080 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1128
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
+ +V SKS N +++ N P F K F
Sbjct: 1129 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1162
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 1163 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1219
Query: 787 M 787
M
Sbjct: 1220 M 1220
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 1070 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1127
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1128 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1187
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1188 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1242
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1243 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1281
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 318 bits (814), Expect = 1e-85
Identities = 321/1195 (26%), Positives = 531/1195 (44%), Gaps = 128/1195 (10%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
Query: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFES 538
PVGT++ T A+D D G NG I Y I P +TT L +
Sbjct: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVD- 217
Query: 539 SPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHIT 598
++ D G + + + N D PL + A + + + +T
Sbjct: 218 -------VLDGDDLGPMFL------PCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVT 264
Query: 599 -AVSAIDID-------ELELVKYKIISGNELG---FFYLNPDSGVLQLKKSLTNSGIKNG 647
+ AID D + + Y I+ G FF+++P + L L + + +
Sbjct: 265 PPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF 324
Query: 648 NFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLN 707
+ ++ +G L ++I +L
Sbjct: 325 DLVIKAEQDNGHPLPAFAGLHIEILD---------------------------------- 350
Query: 708 LEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISD 767
E+ ++++ Y +S P + + L + + L+I A D D +
Sbjct: 351 -ENNQSPYFTMPSYQGYILESAPVGATISDSLNL-TSPLRIVALDKDIEDTKDPELHLFL 408
Query: 768 GNTDSCFNIDME--TGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDAN 825
+ S F + T L +L P+DRE Y +IT +D Q+S ++ I V DAN
Sbjct: 409 NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 466
Query: 826 DNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ-QFAINSSTG 884
DN+P F + SY V + G +IQ+ A D D GSNGE+TY +L Q F IN +TG
Sbjct: 467 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTG 526
Query: 885 IVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPS-SYSV 943
++ +A ++ Y+L ++A D A ++ S+ T+ + + N+ SP P YS+
Sbjct: 527 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
Query: 944 KVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEK 1002
++ E + VG V+ L+ D + G + Y++ N D F + + +G + L K LD E
Sbjct: 587 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 643
Query: 1003 QQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNEN--LHTPYFPDFAVVGSVKENSRIGT 1060
Y L + A D GRP S+ + V + V DVN+N + PY P V + N+ +G
Sbjct: 644 TDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG- 700
Query: 1061 SVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYA 1120
QV A D D+G +G++ YS+ + + L R + +G I A L+RE Y L V A
Sbjct: 701 ---QVKATDPDAGINGQVHYSLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVA 754
Query: 1121 TDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSN 1180
TD V P +ST+ + I+V D++DN+P+ + Y +V EN P +++QI+A+D D +N
Sbjct: 755 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 814
Query: 1181 EKLTYRITSGNPQNFFAINIKTGLITTTSRKLDRE----QQAEHFLEVTVTD--GGPSPK 1234
++YRI S ++FFA++ TG ++ R LD E Q+A V D G P
Sbjct: 815 --VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEAFDIYGTMPPG 871
Query: 1235 QSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERDRKKRGEPIYRAFAFDRDEG--PNAEI 1291
+T+ V+V+ D ND P F +++Y+ + P+ +G PI +A D D P + +
Sbjct: 872 IATVTVIVK--DMNDYPPVFSKRIYKGMVAPD---AVKGTPITTVYAEDADPPGLPASRV 926
Query: 1292 SYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAGSYDI--LTIKAVDNGRPQKSSTARLH 1346
Y + D F ++ +G V +R I L + A D+G P SS+A +
Sbjct: 927 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 986
Query: 1347 IEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAF 1406
I + P IP E + V E +VGV+S N + + IV GN + F
Sbjct: 987 ILVLH---PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
Query: 1407 DAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAV-----------TQVFIKVLDNND 1455
G I + PLD E R+ Y + V+ D V + +V+I++ D N+
Sbjct: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1102
Query: 1456 NGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRK--FRIDP 1513
+ P F + Y +SED T +L+++ATD+D + I I K F ++
Sbjct: 1103 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1162
Query: 1514 STGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTN 1568
TG++ TA + + ++ D A V+V+V + D +N
Sbjct: 1163 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1217
Score = 302 bits (773), Expect = 6e-81
Identities = 313/1112 (28%), Positives = 493/1112 (44%), Gaps = 121/1112 (10%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2536 INDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALD-GGGRTTFCTVRVIVVDEN 2594
+ NP + D RA + RTT T+ V V+D +
Sbjct: 192 ------------------------QYNPDDPD-----RAQNLNERRTTTTTLTVDVLDGD 222
Query: 2595 DNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDPDDGANSR--- 2634
D P F+ + Y+A++ ++ + +QAID D
Sbjct: 223 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 282
Query: 2635 --ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV-DGGIPVKHSL 2691
I YS+ + P + N+ + +KA D G P+ +
Sbjct: 283 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP-AF 341
Query: 2692 IPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWFSTVNGER--- 2747
++I +L P FT Y I E +G+T+ D+L + + + E
Sbjct: 342 AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 401
Query: 2748 PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDV 2800
PE N+ +F + Q T + L + +DRE + F + A D V V V
Sbjct: 402 PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FDGVQESEPVIV 458
Query: 2801 DIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPE 2860
+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++TY + +Q +
Sbjct: 459 NIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD 518
Query: 2861 KVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTALVSVRVTDIND 2919
F I+ TG I+ ++ T+ +V A+D A +S V + V N+
Sbjct: 519 -----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 573
Query: 2920 NAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLV 2978
+P F Q +Y + E+ G V+ L DR+ + +Y I G+P+ F L
Sbjct: 574 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQRVFNLS-- 627
Query: 2979 QSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNSPVCDQVAYTA 3036
++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+PV D
Sbjct: 628 ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 687
Query: 3037 LLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERI 3096
L + +N + +V A D D G NG + YSL N F +G + T L+RE
Sbjct: 688 LSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIYTAVKLNREVR 745
Query: 3097 PVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQ 3154
Y L+ ATDG S + L ++ D++DN PVF++ Y V EN + +++
Sbjct: 746 DYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIE 805
Query: 3155 AVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQSSYNISVRATD 3209
A D D+G N V Y + + F++ +G + L + LD E Q++S V A D
Sbjct: 806 AKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
Query: 3210 QSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNA 3269
G + TVT+ V D+ND PPVF +R Y V D GT + V+A D
Sbjct: 864 IY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 922
Query: 3270 EITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAV 3324
R + Q F++ +G + L+ E F LVV A D G P +S+
Sbjct: 923 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 982
Query: 3325 ATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNG 3383
ATV I + + P +F+Q+ Y +SE A G V ++ A + N I +SIV+G
Sbjct: 983 ATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSG 1037
Query: 3384 DRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAMSSTATVNIDI 3436
+ ++ F ++ + G++ V LD E + Y L VQA + +P+ S+TA V I+I
Sbjct: 1038 NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEI 1097
Query: 3437 SDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEE--EE 3494
D N++ PVF Y + E+ + TS+L++ TD+D+ + I+ +E E
Sbjct: 1098 QDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG 1157
Query: 3495 FVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
FV++ + G++++A++F + + V A D
Sbjct: 1158 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1189
Score = 295 bits (755), Expect = 7e-79
Identities = 325/1166 (27%), Positives = 527/1166 (45%), Gaps = 140/1166 (12%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV---- 190
Query: 874 TQQFAINSSTGIVYVADQLDRESKAN------YSLKIEARDKAESGQQLFSVVTLKVFLD 927
I Y D DR N +L ++ D G L + V +
Sbjct: 191 -----------IQYNPDDPDRAQNLNERRTTTTTLTVDVLD----GDDLGPMFLPCVLVP 235
Query: 928 DVNDCSP----AFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQ-----VRYSLV-- 976
+ DC P A IP ++ E+L V ++ D D + + YS++
Sbjct: 236 NTRDCRPLTYQAAIP---ELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVG 292
Query: 977 --NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRA-KDKGRPVSLSSVSFVEVEVVD 1033
DY F + + + L + ++ + Q ++L ++A +D G P L + + + +E++D
Sbjct: 293 TPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP--LPAFAGLHIEILD 350
Query: 1034 VNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARDED--SGRDGEIQYSI 1082
EN +PYF + G + E++ +G TS L++ A D+D +D E+ +
Sbjct: 351 --ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFL 408
Query: 1083 RDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVN 1142
D + + + + +T +DRE +Y ++ A D V + V I+V D N
Sbjct: 409 NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDAN 466
Query: 1143 DNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKT 1202
DN P E Y V + SVIQ+ A D D SN ++TY I G Q F IN T
Sbjct: 467 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT 525
Query: 1203 GLITTTSRKLDREQQAEHFLEVTVTDGGP--SPKQSTIWVVVQVL-DENDNKPQFPEKVY 1259
GLI T + ++ + L V D P + S V ++VL N + P+FP+ +Y
Sbjct: 526 GLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 584
Query: 1260 QIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF 1319
+++ E R G + A DR+ I+Y+I +G+ F + TG+++ K
Sbjct: 585 SLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKAL 639
Query: 1320 TAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFY--NFTVMESD 1375
S D IL I A D GRP +STA ++I +P+ FD P+ N +V+E +
Sbjct: 640 DRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---FD-PYLPRNLSVVEEE 694
Query: 1376 RVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMS 1432
+ V + P N + + + GNF++ F G+I A L+ E R Y +
Sbjct: 695 ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNREVRDYYELV 751
Query: 1433 VEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
V TDG + + IKVLD +DN P F+ Y V + E++ T ILQIEA D D
Sbjct: 752 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 811
Query: 1490 KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEF----PY 1545
+SY + S F + P TG L LD+EA +I + F
Sbjct: 812 GANVSYRIRS---PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM 868
Query: 1546 RRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKD-KGENAELIY- 1603
+A V V V+D ND+ P F+ +Y+ V A G+ + V A D D G A +
Sbjct: 869 PPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 928
Query: 1604 ---TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAI 1656
++ ++F++E V+ + + +EP TT+ F L + D G P MS++A
Sbjct: 929 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVVVAFDDGEPVMSSSAT 984
Query: 1657 VRISVTMSDNSHPKFIHKDYQ-AEVNENVDIGTSVILISAIS-QSTLIYEVKDGDINGIF 1714
V+I V + P+F ++Y+ V+E GT V +ISA + +++Y + G+ F
Sbjct: 985 VKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
Query: 1715 TINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN---------ATVNIQIVDENDN 1765
IN +GVI LDYE +SY L +QA ++ + +N A V I+I DEN++
Sbjct: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
Query: 1766 APVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV---ESTAKK 1822
PVF Y G +SE A + S L ++ATD D+ +++ Y+++ K+
Sbjct: 1104 PPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1156
Query: 1823 FFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV------EVNIEVTDV 1876
F V++ TG I+T + ++F F V D L+ ++ V +++++V
Sbjct: 1157 GFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1216
Query: 1877 NDNPPVFTQAVFETILLLPTYVGVEV 1902
N P + + + + +L YV ++
Sbjct: 1217 NVPPTLVEKKIEDLTEILDRYVQEQI 1242
Score = 278 bits (712), Expect = 7e-74
Identities = 313/1165 (26%), Positives = 494/1165 (42%), Gaps = 127/1165 (10%)
Query: 2035 IQTTGVPFDREE-QELYELVVEASRELDHLRVARVV---VRVNIEDINDNSPVFVGLPYY 2090
+ +TG DR+ ++ +VV+ + + +V ++ VR+ + D NDNSP F YY
Sbjct: 96 LNSTGRVLDRDPPMNIHSIVVQV--QCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYY 153
Query: 2091 AAVQVDAEPGTLIY-----QVTAIDKDKGPNGEVTYVLQDDYGHFEINPN----SGNVIL 2141
A V GT I+ A D D GPNG++ YV+Q NP+ + N+
Sbjct: 154 ATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ-------YNPDDPDRAQNLNE 206
Query: 2142 KEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPIT------IVNKAMPVFDKPFYTASV 2195
+ + L+ V +L D P V +P T A+P P
Sbjct: 207 RRTTTTTLT-----VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP----EE 257
Query: 2196 NEDIRMNTPILSI----NATSPEGQ-GIIYIIIDGDPF---KQFNIDFDTGVLKVVSPLD 2247
I + PI +I N P + GI+Y I+ G P + F++ T L ++ P++
Sbjct: 258 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 317
Query: 2248 YEVTSAYKLTIRASD-------ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEAS 2300
+ + L I+A A G E+ D N+ P F P+Y + E++
Sbjct: 318 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL------DENNQSPYFTMPSYQGYILESA 371
Query: 2301 LIG---------TPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARM 2351
+G T L++V++D D E+ K + + Y S + + +
Sbjct: 372 PVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 431
Query: 2352 LDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGH 2411
+D E Q T + + D S V+V+I + D NDN P F ++ Y+ YV G
Sbjct: 432 VDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 489
Query: 2412 FVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSV 2471
V + A DAD + Y IL G + F+++ +G+IT++ + + Y+L V
Sbjct: 490 SVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 548
Query: 2472 SDGL-----FTSTAQVHIRVLGANLYS-PAFSQSTYVAEVRENVAAGTKVIHVRATDGDP 2525
+D S V+I VL N S P F Q Y E+ E + G +++++ATD +
Sbjct: 549 ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG 608
Query: 2526 GTYGQISYAIINDFAKDRF-LIDSNGQVITTERLDRENPLEGDVSIFVRALDG-GGRTTF 2583
+ I+YAI N + F L ++ G + + LDRE+ + + A DG T+
Sbjct: 609 DS---ITYAIENGDPQRVFNLSETTGILTLGKALDRES--TDRYILIITASDGRPDGTST 663
Query: 2584 CTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEA 2643
TV ++V D NDNAP F R + V QV+A DPD G N ++ YSL
Sbjct: 664 ATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL---- 719
Query: 2644 SVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPET 2703
+ +L I NG + T N+ V A DG + +HS + + I VL +
Sbjct: 720 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 777
Query: 2704 FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETG 2763
P FT S Y+ + E+ G+T+ L+I + V+ F + TG
Sbjct: 778 NSPVFTNSTYTVLVEENLPAGTTI--LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTG 835
Query: 2764 TIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTV-----DVDIKVLDLNDNKPVFETSS 2818
+ L + LD E P + + T ++ DI T+ V + V D+ND PVF
Sbjct: 836 ELSLLRSLDYEAFP--DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRI 893
Query: 2819 YDTIIMEGMPVGTKLTQVRAIDMDWGA--NGQVTYSLHSDSQPEKVMEAFNIDSNTGWIS 2876
Y ++ GT +T V A D D +V Y + D Q F ++ ++G +
Sbjct: 894 YKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVEEDSGRVI 952
Query: 2877 TLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYR-GNVKE 2935
T +L+ E F VVA D GE +SS+A V + V + P F QE YR V E
Sbjct: 953 TRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSE 1010
Query: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQ 2995
G +V V+S + +N+ + Y I GN F + + +YV PLD E +
Sbjct: 1011 LATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFGINNITG--VIYVNGPLDYETR 1063
Query: 2996 DIYFLNITATDGLFV-----------TQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPS 3044
Y L + A D L V A V + + D N++ PV + Y + ED
Sbjct: 1064 TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARM 1122
Query: 3045 NKIILKVSAKDADIGSNGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
+L+V A D D G+ + Y L G F ++ +G +KT L R +
Sbjct: 1123 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFK 1182
Query: 3101 LMAKATDGGGRFCQSNIHLILEDVN 3125
ATD G+ +++ VN
Sbjct: 1183 FQVIATDDYGKGLSGKADVLVSVVN 1207
Score = 271 bits (693), Expect = 1e-71
Identities = 310/1129 (27%), Positives = 481/1129 (42%), Gaps = 116/1129 (10%)
Query: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHYQIV 2327
V ++V D NDN P F +Y T++E + +GT + S D D N + Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
Query: 2328 QDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDV 2387
YN D A+ L+ TL V +D L L + + +
Sbjct: 192 --QYNPDDPDR----------AQNLNERRTTTTTLTVDVLDG--DDLGPMFLPCVLVPNT 237
Query: 2388 NDNPPVFNQLIYESYVSELAPRGHF-----VTCVQASDAD-----SSDFDRLEYSILSGN 2437
D P L Y++ + EL +QA D D SD + YSIL G
Sbjct: 238 RDCRP----LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 293
Query: 2438 DR---TSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG---LFTSTAQVHIRVLGANL 2491
F M ++ ++L + + L + + A +HI +L N
Sbjct: 294 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 353
Query: 2492 YSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD-PGTYGQISYAIINDFAK 2541
SP F+ +Y + E+ G T + + A D D T + +ND+
Sbjct: 354 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYT- 412
Query: 2542 DRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAP 2598
F + G + + +DRE + + + A DG + V + V+D NDN P
Sbjct: 413 SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTP 470
Query: 2599 QFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNG 2658
F + Y V D+ G V Q+ A+D D+G+N ITY + A D + I+ G
Sbjct: 471 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ---GDFI-INKTTG 526
Query: 2659 WMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHVLPPET-FLPSFTQSQYSF 2715
+ + + V+A D P ++S+ VYI VLPP P F Q YS
Sbjct: 527 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
Query: 2716 TIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDR 2773
I+E +G+ + L+ + ++ ++ NG+ P+ +F + + TG + L K LDR
Sbjct: 587 EISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----VFNLSETTGILTLGKALDR 641
Query: 2774 ETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKL 2833
E++ + + A+ + D T V+I V D+NDN PVF+ + + +
Sbjct: 642 ESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV 699
Query: 2834 TQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSV 2893
QV+A D D G NGQV YSL + + F I SN G I T L+ E + V
Sbjct: 700 GQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSIYTAVKLNREVRDYYELVV 752
Query: 2894 VASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDT 2953
VA+D G ST ++++V DI+DN+PVF Y V+E+ P G + + D
Sbjct: 753 VATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD--- 808
Query: 2954 SDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-----EQDIYFLNITATDGL 3008
D+ VSY I + FAL E + + R LD E E I FL + A D +
Sbjct: 809 VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFL-VEAFD-I 864
Query: 3009 FVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGS--NG 3062
+ T A V V V D+ND PV + Y ++ D I V A+DAD
Sbjct: 865 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 924
Query: 3063 YIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIH 3118
+RY + + S F ++ +SG + T L+ E ++ L+ A D G S+
Sbjct: 925 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 984
Query: 3119 L-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSL-ADSAGG 3176
+ IL P F+ + Y ATK + V + IN+ +VYS+ + +
Sbjct: 985 VKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVSGNEED 1041
Query: 3177 VFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSPGQSLSSLTTVTITVLDIN 3230
F I++ +G+I + PLD E ++SY + V+A S S+ V I + D N
Sbjct: 1042 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1101
Query: 3231 DNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITY-LIRSGNEQGK--FKIN 3287
++PPVF+++ Y+ V ED T VL V AT KD G + + Y LI ++GK F +
Sbjct: 1102 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1161
Query: 3288 PKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVND 3336
TG I + + F V A D LS A V +++ + D
Sbjct: 1162 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
Score = 266 bits (681), Expect = 3e-70
Identities = 307/1141 (26%), Positives = 494/1141 (43%), Gaps = 120/1141 (10%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 81 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 135
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSLYSEA 2643
+V D NDN+P F Y A+V G + A D DDG N +I Y +
Sbjct: 136 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
Query: 2644 SVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIH-VLPPE 2702
DPD N N+ + T + V +DG L P+++ VL P
Sbjct: 196 D---------DPDRA-----QNLNERRTTTTTLTVDVLDG-----DDLGPMFLPCVLVPN 236
Query: 2703 T----------FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQN---VWFSTVNGERPE 2749
T +P + I I + I P + + +S + G PE
Sbjct: 237 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVG-TPE 295
Query: 2750 NNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVD---IVFTVDVDIKVLD 2806
+ F + T + L + ++R+ FH K I ++ + + + I++LD
Sbjct: 296 DYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 350
Query: 2807 LNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------VRAIDMDWGANGQVTYSLHSDSQP 2859
N+ P F SY I+E PVG ++ +R + +D LH
Sbjct: 351 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 410
Query: 2860 EKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDIND 2919
+ T +++ L+ +D E T+TFS+ A D S +V+++V D ND
Sbjct: 411 YTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAND 467
Query: 2920 NAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQ 2979
N P F + Y V PG+ V L+ D D N +++Y I G +G F + +
Sbjct: 468 NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS-NGEITYEILVG-AQGDFIIN--K 523
Query: 2980 SEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ-----AMVEVSVSDVNDNSPV-CDQVA 3033
+ + + ++ Y L + A D + V + V N+ SP Q+
Sbjct: 524 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 583
Query: 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-YGSGNSEFFLDPESGELKTLALLD 3092
Y+ + E + ++L + A D + S I Y++ G F L +G L LD
Sbjct: 584 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALD 640
Query: 3093 RERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNPPVFSSDHY---NTCVYENTATKA 3148
RE Y L+ A+DG + +++++ DVNDN PVF D Y N V E A A
Sbjct: 641 RESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEA-NA 697
Query: 3149 LLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRAT 3208
+ +V+A DPD GIN +V YSL + +F I +S+G I L+RE + Y + V AT
Sbjct: 698 FVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVAT 755
Query: 3209 DQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTN 3268
D + S+L T+ I VLDI+DN PVF Y V V E+ GT +L + A D+G N
Sbjct: 756 DGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 814
Query: 3269 AEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC----KRFYLVVEAKDGGTPALSAV 3324
++Y IRS + F ++P TG +S+ LDYE +VEA D +
Sbjct: 815 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 872
Query: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVD--SQPNGQIHFSIVN 3382
ATV + + D+ND PP FS+ +Y +++ DA+ G + + AED D P ++ + + +
Sbjct: 873 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 932
Query: 3383 GD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDV 3439
+ F V+ G V + L+ E + + L+V A D G P MSS+ATV I +
Sbjct: 933 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 992
Query: 3440 NDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEF-VL 3497
+ P FT Y + E GT + + + +SI+SGNEE+ F +
Sbjct: 993 GE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ-----SIVYSIVSGNEEDTFGIN 1046
Query: 3498 DPHGILRSAVVFQHTESLEYVLCVQA-------KDSGKPQQVSHTYIRVRVIEESTHKPT 3550
+ G++ + YVL VQA + P + + + + + +E+ H P
Sbjct: 1047 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
Query: 3551 AIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLTFAL----KSEQKSLFKVNSHDGK 3604
ED + ++ ATD+D Y V+ + L E K F V ++ G
Sbjct: 1107 FQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1166
Query: 3605 I 3605
I
Sbjct: 1167 I 1167
Score = 262 bits (670), Expect = 5e-69
Identities = 275/1040 (26%), Positives = 465/1040 (44%), Gaps = 106/1040 (10%)
Query: 1444 TQVFIKVLDNNDNGPEFSQ----PN--------YDVTISE-----DVLPDTEILQIEATD 1486
T + + VLD +D GP F PN Y I E ++ P I+A D
Sbjct: 212 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 271
Query: 1487 RD-------EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVR 1539
+D ++ + Y++ R F + P T L E ++ + K L I
Sbjct: 272 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 331
Query: 1540 DQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAV---------LQVTA 1590
A + + + D N+ SPYFT P Y+ + ESA +G+ + L++ A
Sbjct: 332 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 391
Query: 1591 LDKDKGENAELIYTIEAGNTGNMFKIEP--VLGIITICKEPDMTTMGQFVLSIKVTD--Q 1646
LDKD + + + + ++F + + +T+ + D + SI D Q
Sbjct: 392 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 451
Query: 1647 GSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI-----SQSTL 1701
S P+ IV I V ++++ P F Y V ++ G SVI ++A+ S +
Sbjct: 452 ESEPV----IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 507
Query: 1702 IYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMA----SNATVNI 1757
YE+ G G F IN +G+IT ++ +Y L +QA + A A S TV I
Sbjct: 508 TYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 566
Query: 1758 QIVDENDNAPV-FLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV 1816
+++ N+ +P F YS +SEA + +++ L ++ATD + + + Y I
Sbjct: 567 EVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL-------LNLQATDREGDS---ITYAIE 616
Query: 1817 ESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDV 1876
++ F + +TG + LD E+ + + D G P T S VNI VTDV
Sbjct: 617 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT--STATVNIVVTDV 673
Query: 1877 NDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDH-FLIDSN 1935
NDN PVF + + ++ V +V ATDPD+ + ++ YSL G+ ++ F I SN
Sbjct: 674 NDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN 731
Query: 1936 SGVLT-IKNNNLSKDHYMLIVKVSDGKF---YSTSMVTIMVKEAMDSGLHFTQSFYSTSI 1991
+ T +K N +D+Y L+V +DG +ST + I V + D+ FT S Y+ +
Sbjct: 732 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 791
Query: 1992 SENNTNITKVAIVNAVGNRLNEPLKYSILNPGNK--FKIKSTSG---VIQTTGVPFDREE 2046
EN T + + A L + Y I +P K F + +G ++++ ++
Sbjct: 792 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 851
Query: 2047 QELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQV 2106
+ +VEA + V V ++D+ND PVF Y V DA GT I V
Sbjct: 852 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 911
Query: 2107 TAIDKDKG--PNGEVTYVLQD-----DYGHFEINPNSGNVILKEAFNSDLSNIEYGVTIL 2159
A D D P V Y + D FE+ +SG VI + N + + I + + ++
Sbjct: 912 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI-FKLVVV 970
Query: 2160 AKDGGKPSLSTSVELPITIVNKA-MPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGI 2218
A D G+P +S+S + I +++ +P F + Y ++ ++ + + + Q I
Sbjct: 971 AFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1030
Query: 2219 IYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVD---- 2274
+Y I+ G+ F I+ TGV+ V PLDYE ++Y L ++A D+L A + V
Sbjct: 1031 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1089
Query: 2275 -----LLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQ-IVQ 2328
+ + D N++PP+F + Y +SE + + T VL+V + D D+ N ++ Y+ I+
Sbjct: 1090 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1149
Query: 2329 DTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVN 2388
+ F +++ +GLI TA + + + +V + D LS + V +
Sbjct: 1150 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV------ 1203
Query: 2389 DNPPVFNQLIYESYVSELAP 2408
V NQL + VS + P
Sbjct: 1204 ---SVVNQLDMQVIVSNVPP 1220
Score = 251 bits (640), Expect = 2e-65
Identities = 306/1242 (24%), Positives = 516/1242 (41%), Gaps = 108/1242 (8%)
Query: 2303 GTPVLQVVSIDADSENNK-MVHYQIVQDTY------------NSTDYFHIDSSSGLIL-- 2347
G P +V+ID +S N +V +++ T ++ DY+ + +L
Sbjct: 37 GGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFL 96
Query: 2348 --TARMLDHEL---VQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESY 2402
T R+LD + + ++V+ I+ ++ V I + D NDN P F Y +
Sbjct: 97 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHE-VRIVVRDRNDNSPTFKHESYYAT 155
Query: 2403 VSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRME 2462
V+EL P G + + D ++D D N + +++ + + +R
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDD------GPNGQIEYVIQYNPDDPDRAQNLNERRT 209
Query: 2463 PLYSLNVSVSDG-----LFTSTAQV-HIRVLGANLYSPAFSQSTYVAE-----VRENVAA 2511
+L V V DG +F V + R Y A + E V + A
Sbjct: 210 TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQA 269
Query: 2512 GTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIF 2571
+ +++ PG I D+ + + ++ E ++R+ + D+ I
Sbjct: 270 IDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 329
Query: 2572 VRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVT---------QV 2622
+G F + + ++DEN+ +P F Y+ + G ++ ++
Sbjct: 330 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 389
Query: 2623 QAIDPD--DGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKA 2680
A+D D D + + L SV I ++ ++ + +F + A
Sbjct: 390 VALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI---TRYLTLLQPVDREEQQTYTFSITA 446
Query: 2681 VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWF 2740
DG + + V I V+ P+F + Y + D G +V L + +
Sbjct: 447 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 504
Query: 2741 STVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAA---TIPLDKVDIVFT 2797
+ E +G F+I + TG I + ++ + V A P ++ + + T
Sbjct: 505 GEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
Query: 2798 VDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDS 2857
V +++ + N + P F Y I E M VG L ++A D + +TY++ +
Sbjct: 564 VYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAI-ENG 618
Query: 2858 QPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDI 2917
P++V FN+ TG ++ K LD E+ + + ASD G +STA V++ VTD+
Sbjct: 619 DPQRV---FNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDV 673
Query: 2918 NDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGL 2977
NDNAPVF + R + V + D D + +N QV Y + GN F
Sbjct: 674 NDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPD-AGINGQVHYSL--GNFNNLFR--- 727
Query: 2978 VQSEWKVYVKRPLDREEQDIYFLNITATDGLF---VTQAMVEVSVSDVNDNSPVCDQVAY 3034
+ S +Y L+RE +D Y L + ATDG + + + V D++DNSPV Y
Sbjct: 728 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 787
Query: 3035 TALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLALLDR 3093
T L+ E++P+ IL++ AKD D+G+N + Y + FF L P +GEL L LD
Sbjct: 788 TVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDY 845
Query: 3094 ERIP----VYSLMAKATDGGGRFCQ--SNIHLILEDVNDNPPVFSSDHYNTCVYENTATK 3147
E P + + +A D G + + +I++D+ND PPVFS Y V +
Sbjct: 846 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 905
Query: 3148 ALLTRVQAVDPD-IGINRKVVYSLADSA-----GGVFSIDSSSGIIILEQPLDREQQSSY 3201
+T V A D D G+ V D +F ++ SG +I L+ E + +
Sbjct: 906 TPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIF 965
Query: 3202 NISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFAT 3261
+ V A D +SS TV I VL + P + V E + GT V + A
Sbjct: 966 KLVVVAFDDGE-PVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA 1024
Query: 3262 SKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEA-------K 3314
+ N I Y I SGNE+ F IN TG I V+ LDYE + L V+A
Sbjct: 1025 A----INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1080
Query: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNG 3374
+ P+ S A V I + D N++PP F + Y +SEDA + SV+ + A D D+
Sbjct: 1081 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1140
Query: 3375 QIHFSIV---NGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTAT 3431
+ + ++ + F V+ GL+K R S + V A D +S A
Sbjct: 1141 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1200
Query: 3432 VNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDR 3473
V + + + D + + T V ++ + + T IL V ++
Sbjct: 1201 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDL-TEILDRYVQEQ 1241
Score = 247 bits (630), Expect = 2e-64
Identities = 313/1171 (26%), Positives = 493/1171 (42%), Gaps = 159/1171 (13%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 198 KNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIE 257
+ D N +E+ R L VD + + + V +
Sbjct: 192 QYNPD-----------DPDRAQNLNER-RTTTTTLTVD----VLDGDDLGPMFLPCVLVP 235
Query: 258 RINEHAPTIHVVTHVPFSLEKEPTYAVVT--VDDLDDGANGEIES------VSIVAGDPL 309
+ P + +E +VT + +D N + S SI+ G P
Sbjct: 236 NTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE 295
Query: 310 DQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAK-DKGSPQKCSALKAVYIGNPT 368
D E + E D F ++L ++A+ D G P A ++I
Sbjct: 296 DYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQDNGHP--LPAFAGLHIEILD 350
Query: 369 RDTVPIRFEKEVYDVSISEFSPPGV-------------VVAIVKLSPEPIDVEYKLSPGE 415
+ F Y I E +P G +VA+ K + D E L +
Sbjct: 351 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 410
Query: 416 DAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTNKEGDLKAQ---VTISIEDANDHT 469
F + ++G+ + +P++ +++ Y +T +G +++ V I + DAND+T
Sbjct: 411 YTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 469
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVIS 529
P F + YD YV + G SV+ ++A D D+G NG ITY I F+IN+ TG+I+
Sbjct: 470 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 529
Query: 530 TTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVTIRIGNVNDNS-PLFEKVACQGVI 587
++ Y V+A+D P R S V I + N+ S P F ++ I
Sbjct: 530 IAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 588
Query: 588 SYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNG 647
S VG + + A D E + + Y I +G+ F L+ +G+L L K+L
Sbjct: 589 SEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKALDRE--STD 645
Query: 648 NFALRITATDGE-NLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKL 706
+ L ITA+DG + ++NI V
Sbjct: 646 RYILIITASDGRPDGTSTATVNIVVT---------------------------------- 671
Query: 707 NLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS 766
+N P FD P +++V E+ A + ++KA D D+G NG+V +++
Sbjct: 672 ----------DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL- 719
Query: 767 DGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDAND 826
GN ++ F I G + + ++RE D Y L + D + S L I V D +D
Sbjct: 720 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 777
Query: 827 NSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINSSTG 884
NSPVF +Y+V + E+ GT I+Q+EA+D DLG+N V+Y + + + FA++ TG
Sbjct: 778 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 835
Query: 885 IVYVADQLDRES----KANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
+ + LD E+ +A+ + +EA D G + T+ V + D+ND P F
Sbjct: 836 ELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRI 893
Query: 941 YSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSLVNDYN-----GRFEIDKASGAIR 993
Y V D GT I + E DP +VRY V+D FE+++ SG +
Sbjct: 894 YKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR-VDDVQFPYPASIFEVEEDSGRVI 952
Query: 994 LSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV----V 1049
L+ E + L V A D G PV +SS + V++ V LH P F
Sbjct: 953 TRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRP 1005
Query: 1050 GSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRE 1109
V E + GT V ++A + + I YSI G+ F I++ +GVI LD E
Sbjct: 1006 PPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYE 1061
Query: 1110 TMGSYWLTVYATDRGVV-------PLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSP 1162
T SY L V A VV +T +VYIE++D N++ P+ + Y V E++
Sbjct: 1062 TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDAR 1121
Query: 1163 KDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFFAINIKTGLITTTSRKLDREQQAE 1219
SV++++A D D+ + + YR+ + F + TGLI T L +
Sbjct: 1122 MFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRS 1179
Query: 1220 HF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+F +V TD G S K + VV LD
Sbjct: 1180 YFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
Score = 243 bits (621), Expect = 2e-63
Identities = 295/1168 (25%), Positives = 511/1168 (43%), Gaps = 119/1168 (10%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 128
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 129 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
Query: 971 VRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
+ Y V YN + D+A + L+ + LTV D + +
Sbjct: 187 IEY--VIQYNPD-DPDRA-------QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 236
Query: 1031 VVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDED----SGRDGEIQYSIRDGS 1086
D + P+ + N I T +Q +D + S R G I YSI G+
Sbjct: 237 TRDCRPLTYQAAIPELRTPEEL--NPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGT 293
Query: 1087 GLGR---FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVND 1143
F + + ++ + ++R+ + L + A PL + ++IE+ D N+
Sbjct: 294 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 353
Query: 1144 NAPLTSEPIYYPVVMENSPKDVSV---------IQIQAEDPDSSSNEKLTYRITSGNPQN 1194
+P + P Y ++E++P ++ ++I A D D + + + +
Sbjct: 354 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS 413
Query: 1195 FFAINIKTGLIT--TTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKP 1252
F + +TG+ T + +DRE+Q + +T DG + + V +QV+D NDN P
Sbjct: 414 VFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTP 470
Query: 1253 QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGM 1312
FPE Y + + R G+ + + A D DEG N EI+Y I+ G G F I+ TG+
Sbjct: 471 TFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGL 527
Query: 1313 VSSRK--QFTAGSYDILTIKAVDNGRP--QKSSTARLHIEWIKKPPPSPIPLTFDEPFYN 1368
++ + G LT++A DN P +++S ++IE + PP + P F + Y+
Sbjct: 528 ITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL--PPNNQSPPRFPQLMYS 585
Query: 1369 FTVMESDRVTEIV-GVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRS 1427
+ E+ RV ++ + + + + I G+ F+ + G + + K LD E
Sbjct: 586 LEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 645
Query: 1428 IYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGPEFSQ--PNYDVTISEDVLPDTEILQIE 1483
Y + + +DG + V I V D NDN P F P + E+ + + Q++
Sbjct: 646 RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVK 703
Query: 1484 ATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEF 1543
ATD D ++ VH S+ + + FRI S G +YTA +L+ E +D + L ++ D
Sbjct: 704 ATDPDAG--INGQVHYSLGNFN-NLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAV 759
Query: 1544 PYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIY 1603
R + + + V D +D+SP FTN Y V E+ G+ +LQ+ A D D G N Y
Sbjct: 760 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVS--Y 817
Query: 1604 TIEAGNTGNMFKIEPVLGIITICKE------PDMTTMGQFVLSIKVTDQGSPPMSATAIV 1657
I + + F + P G +++ + PD F++ PP AT V
Sbjct: 818 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT--V 875
Query: 1658 RISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISA-------ISQSTLIYEVKDGDI 1710
+ V ++ P F + Y+ V + GT + + A + S + Y V D
Sbjct: 876 TVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF 935
Query: 1711 ---NGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDN 1765
IF + SG + T+ L+ E T+ ++L++ A + M+S+ATV I ++ +
Sbjct: 936 PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE- 994
Query: 1766 APVFLFSQY-SGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFF 1824
P F +Y +SE A ++V + + + N +VY IV + F
Sbjct: 995 IPRFTQEEYRPPPVSELATKGTMVGVISAAAI-----------NQSIVYSIVSGNEEDTF 1043
Query: 1825 TVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQL------TAESPVEVNIEVTDVND 1878
+++ TG I LD+ET + V DS L + + +V IE+ D N+
Sbjct: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENN 1102
Query: 1879 NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLM-----EGSLDHFLID 1933
+PPVF + + + + VL+V ATD D+ + Y L+ EG + F+++
Sbjct: 1103 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK-EGFVVE 1161
Query: 1934 SNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
+ +G++ + +N+ + ++ V +D
Sbjct: 1162 TYTGLIKTAMLFHNMRRSYFKFQVIATD 1189
Score = 240 bits (613), Expect = 2e-62
Identities = 299/1241 (24%), Positives = 499/1241 (40%), Gaps = 199/1241 (16%)
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1716 INPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFL----- 1770
NP + L+ RT++ T+ + ++D +D P+FL
Sbjct: 193 YNPDDP--DRAQNLNERRTTT----------------TTLTVDVLDGDDLGPMFLPCVLV 234
Query: 1771 -FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSNRNAL-----LVYQIVESTA 1820
++ L+ A I + + +P++ I+A D D N ++Y I+ T
Sbjct: 235 PNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTP 294
Query: 1821 K---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVN 1877
+ +FF + T + + ++ + F + L A + + +IE+ D N
Sbjct: 295 EDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL--HIEILDEN 352
Query: 1878 DNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSG 1937
+ P FT +P+Y G Y L + + DS +
Sbjct: 353 NQSPYFT---------MPSYQG--------------------YILESAPVGATISDSLNL 383
Query: 1938 VLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTN 1997
++ L KD +++ D LH + Y++ + T
Sbjct: 384 TSPLRIVALDKD----------------------IEDTKDPELHLFLNDYTSVFTVTQTG 421
Query: 1998 ITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEAS 2057
IT+ T P DREEQ+ Y + A
Sbjct: 422 ITRYL----------------------------------TLLQPVDREEQQTYTFSITA- 446
Query: 2058 RELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPN 2116
D ++ + V+V + + D NDN+P F + Y V D PG + Q+TA+D D+G N
Sbjct: 447 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 504
Query: 2117 GEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKP-----SLST 2170
GE+TY +L G F IN +G + + + Y +T+ A D P S+ T
Sbjct: 505 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPPAERRNSICT 563
Query: 2171 SVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQ 2230
+ N++ P F + Y+ ++E +R+ +L++ AT EG I Y I +GDP +
Sbjct: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
Query: 2231 FNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQ- 2289
FN+ TG+L + LD E T Y L I ASD + TV+++V DVNDN P+FD
Sbjct: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
Query: 2290 -PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILT 2348
P + + E + V QV + D D+ N VHY + N + F I +S+G I T
Sbjct: 684 LPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRI-TSNGSIYT 736
Query: 2349 ARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAP 2408
A L+ E+ + L V + D S + + I + D++DN PVF Y V E P
Sbjct: 737 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 796
Query: 2409 RGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLN 2468
G + ++A D D + Y I S + F + +G ++L P +
Sbjct: 797 AGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEAS 854
Query: 2469 VSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRAT 2521
++ F A V + V N Y P FS+ Y V + GT + V A
Sbjct: 855 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 914
Query: 2522 DGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTERLDRENPLEGDVSIFVRAL 2575
D DP ++ Y + + + F + + +G+VIT L+ E + V A
Sbjct: 915 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAF 972
Query: 2576 DGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG-RGHLVTQVQAIDPDDGAN 2632
D G ++ TV+++V+ + P+F EYR +++ +G +V + A N
Sbjct: 973 DDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA----AIN 1027
Query: 2633 SRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKA-------VDGGI 2685
I YS+ S + D I+ G + G + T V+A + +
Sbjct: 1028 QSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRV 1084
Query: 2686 PVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFST--- 2742
P K + VYI + P F + Y ++ED + ++V ++ +S
Sbjct: 1085 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1144
Query: 2743 --VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPL-----DKVDIV 2795
+ E +G FV+E TG IK F F+V AT K D++
Sbjct: 1145 RLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1202
Query: 2796 FTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
+V +D++V+ N + E T D + E +P
Sbjct: 1203 VSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1243
Score = 238 bits (608), Expect = 8e-62
Identities = 278/1082 (25%), Positives = 465/1082 (42%), Gaps = 121/1082 (11%)
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1498 HSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIV-NV 1556
+ D DP A+ L+ L + V D + L V+V N
Sbjct: 192 QYNPD---------DPDR-----AQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 237
Query: 1557 EDANDHSPYFTNPL-YEASVFESAA---LGSAVLQ--VTALDKDKG-----ENAELIYTI 1605
D PL Y+A++ E L ++ + A+D+D+ + ++Y+I
Sbjct: 238 RDCR--------PLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 289
Query: 1606 EAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVT 1662
G + F + P +++ + + +F L IK P+ A A + I +
Sbjct: 290 LVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL 349
Query: 1663 MSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQSTLIYEVKD------ 1707
+N P F YQ + E+ +G TS + I A+ + I + KD
Sbjct: 350 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD--IEDTKDPELHLF 407
Query: 1708 -GDINGIFTINPYSGV---ITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDEN 1763
D +FT+ +G+ +T + +D E +Y I A + + VNIQ++D N
Sbjct: 408 LNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDAN 466
Query: 1764 DNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKK 1822
DN P F Y + ++ P +S+++ + A DAD N + Y+I+ A+
Sbjct: 467 DNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGSNGEITYEILVG-AQG 517
Query: 1823 FFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVND-NPP 1881
F ++ +TG I ++ + V D+ P S V IEV N+ +PP
Sbjct: 518 DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 577
Query: 1882 VFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDH-FLIDSNSGVLT 1940
F Q ++ + VG +L + ATD + + +TY++ G F + +G+LT
Sbjct: 578 RFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILT 634
Query: 1941 IKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLHFTQSF---YSTSISE 1993
+ + S D Y+LI+ SDG+ ST+ V I+V + D+ F S E
Sbjct: 635 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 694
Query: 1994 NNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELV 2053
N + +V + +N + YS+ N N F+I S + T V +RE ++ YELV
Sbjct: 695 ANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--TAVKLNREVRDYYELV 751
Query: 2054 VEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDK 2113
V A+ H R + + + + + DI+DNSPVF Y V+ + GT I Q+ A D D
Sbjct: 752 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 811
Query: 2114 GPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIEYGVTILAKDGGKPSL 2168
G N + F ++P +G + L EAF ++I + V G P
Sbjct: 812 GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 871
Query: 2169 STSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQG-----IIYIII 2223
+V + + +N PVF K Y V D TPI ++ A + G + Y +
Sbjct: 872 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 931
Query: 2224 DGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDALTGARAEVTVDLLVND 2279
D P F ++ D+G + L+ E T+ +KL + A D + TV +LV
Sbjct: 932 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH 991
Query: 2280 VNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHI 2339
+ P + +SE + GT +V + + + N+ + Y IV N D F I
Sbjct: 992 PGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVYSIVSG--NEEDTFGI 1045
Query: 2340 DSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPP 2392
++ +G+I LD+E VQ +L+V + PS S+ V+I I D N++PP
Sbjct: 1046 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1105
Query: 2393 VFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL---SGNDRTSFLMDSKSG 2449
VF + Y VSE A V V+A+D D+ ++ + Y ++ + F++++ +G
Sbjct: 1106 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG 1165
Query: 2450 VI 2451
+I
Sbjct: 1166 LI 1167
Score = 237 bits (604), Expect = 2e-61
Identities = 307/1224 (25%), Positives = 520/1224 (42%), Gaps = 145/1224 (11%)
Query: 1047 AVVGSVKENSRIGTSVLQ-VTARDEDSGRDGEIQYSIRDGSGLGRFS--IDDESGVITAA 1103
A + ++ E SR GT ++ + + G D I+ S++D + + +
Sbjct: 41 ATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTG 100
Query: 1104 DILDRE---TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMEN 1160
+LDR+ + S + V ++ V + EV I V D NDN+P YY V E
Sbjct: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESYYATVNEL 159
Query: 1161 SPKDVSVI-----QIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDRE 1215
+P ++ A D D N ++ Y I A N+ TTT+
Sbjct: 160 TPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTT------ 213
Query: 1216 QQAEHFLEVTVTDG---GPSPKQSTIWVVVQVLDENDNKP-QFPEKVYQIKLPERDRKKR 1271
L V V DG GP V V + D +P + + +++ PE
Sbjct: 214 ------LTVDVLDGDDLGP-----MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII 262
Query: 1272 GEPIYRAFAFDRDEGPNAE---ISYSIVDG--NDDGKFF-IDPKTGMVSSRKQFTAG--- 1322
P +A DR+ P ++ I YSI+ G D +FF + P+T +S +
Sbjct: 263 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 322
Query: 1323 SYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV----- 1377
+D++ DNG P + A LHIE + + SP F P Y ++ES V
Sbjct: 323 KFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATIS 378
Query: 1378 -----TEIVGVVS----VQPANTPLWFDIVGGNFDSAFDAEKGVGT--IVIAKPLDAEQR 1426
T + +V+ ++ P + ++ S F + T + + +P+D E++
Sbjct: 379 DSLNLTSPLRIVALDKDIEDTKDP-ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQ 437
Query: 1427 SIYNMSVEVTDGTNVAVTQVF-IKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEAT 1485
Y S+ DG + + I+V+D NDN P F + +YDV + D+ P ++Q+ A
Sbjct: 438 QTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAV 497
Query: 1486 DRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFP- 1544
D DE T + + F I+ +TG++ A ++ + L + D P
Sbjct: 498 DADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 555
Query: 1545 -YRRNLARVIVNVEDANDHS-PYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELI 1602
R ++ V + V N+ S P F +Y + E+ +G+ +L + A D+ E +
Sbjct: 556 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSIT 612
Query: 1603 YTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVT 1662
Y IE G+ +F + GI+T+ K D + +++L I +D G P ++TA V I VT
Sbjct: 613 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT 671
Query: 1663 MSDNSHPKF----------IHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDGDING 1712
+++ P F + ++ A V + + + S G+ N
Sbjct: 672 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-------GNFNN 724
Query: 1713 IFTINPYSGVITTQKALDYERTSSYQLIIQATNMA--GMASNATVNIQIVDENDNAPVFL 1770
+F I +G I T L+ E Y+L++ AT+ A S T+ I+++D +DN+PVF
Sbjct: 725 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 783
Query: 1771 FSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSST 1830
S Y+ + E P + + L I A D D N + Y+I K FF + T
Sbjct: 784 NSTYTVLVEENLPAGTTI-------LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFT 834
Query: 1831 GAIRTIANLDHETI----AHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQA 1886
G + + +LD+E A F V D V + V D+ND PPVF++
Sbjct: 835 GELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKR 892
Query: 1887 VFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDH---------FLIDSNSG 1937
+++ ++ G + V A D D PP L S + +D F ++ +SG
Sbjct: 893 IYKGMVAPDAVKGTPITTVYAEDAD---PPGLPASRVRYRVDDVQFPYPASIFEVEEDSG 949
Query: 1938 VLTIKNNNLSKD----HYMLIVKVSDGKFYSTSMVTIMVKEAMDSGL-HFTQSFY-STSI 1991
I NL+++ +++V DG+ +S T+ + + FTQ Y +
Sbjct: 950 -RVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPV 1008
Query: 1992 SENNTNITKVAIVNAVGNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQEL 2049
SE T T V +++A +N+ + YSI+ N + F I + +GVI G P D E +
Sbjct: 1009 SELATKGTMVGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTS 1065
Query: 2050 YELVVEASR---ELDHLRVA----RVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTL 2102
Y L V+A L +LRV V + I+D N++ PVF Y V DA T
Sbjct: 1066 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1125
Query: 2103 IYQVTAIDKDKGPNGEVTYVL-----QDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVT 2157
+ +V A DKD G + Y L ++ F + +G + F+ ++ +
Sbjct: 1126 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFH-NMRRSYFKFQ 1184
Query: 2158 ILAKDGGKPSLSTSVELPITIVNK 2181
++A D LS ++ +++VN+
Sbjct: 1185 VIATDDYGKGLSGKADVLVSVVNQ 1208
Score = 228 bits (580), Expect = 1e-58
Identities = 280/1096 (25%), Positives = 471/1096 (42%), Gaps = 138/1096 (12%)
Query: 759 GKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLT 818
G +FT G+ + D GQ++ ++ + + D N+ N ++++ LT
Sbjct: 163 GTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDR-AQNL------NERRTTTTTLT 215
Query: 819 INVEDANDNSPVFIQD------------SYSVNILE-------SSGIGTEIIQVEARDKD 859
++V D +D P+F+ +Y I E + I T IQ +D++
Sbjct: 216 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 275
Query: 860 LGSNGE---VTYSVLTDTQQ-----FAINSSTGIVYVADQLDRESKANYSLKIEARDKAE 911
+ + + YS+L T + F ++ T + + + ++R+ + L I+A + +
Sbjct: 276 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQD 333
Query: 912 SGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIA--------------- 956
+G L + L + + D N+ SP F SY +LE PVG I+
Sbjct: 334 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 393
Query: 957 --WLETHDPDLGLGGQVRYSLVNDYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRA 1012
+T DP+L L +NDY F + + + + L + +D E+QQ Y ++ A
Sbjct: 394 KDIEDTKDPELHL-------FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 446
Query: 1013 KDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDS 1072
D V S V ++V+D N+N TP FP+ + V + R G SV+Q+TA D D
Sbjct: 447 FD---GVQESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 501
Query: 1073 GRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRG--VVPLYS 1130
G +GEI Y I G+ G F I+ +G+IT A ++ +Y LTV A D S
Sbjct: 502 GSNGEITYEILVGA-QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 560
Query: 1131 TIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITS 1189
VYIEV N+ +P + Y + + + + +V + +QA D + S +TY I +
Sbjct: 561 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 617
Query: 1190 GNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDEND 1249
G+PQ F ++ TG++ T + LDRE + L +T +DG P ST V + V D ND
Sbjct: 618 GDPQRVFNLSETTGIL-TLGKALDRESTDRYILIITASDGRPD-GTSTATVNIVVTDVND 675
Query: 1250 NKPQF-PEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDP 1308
N P F P + + E + + + A D D G N ++ YS+ GN + F I
Sbjct: 676 NAPVFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 730
Query: 1309 KTGMVSSRK-QFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFY 1367
+ ++ K Y L + A D + ST L I+ + SP+ F
Sbjct: 731 NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FT 783
Query: 1368 N--FTVMESDRVTEIVGVVSVQPANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPL 1421
N +TV+ + + ++ ++ + L + I F G + + + L
Sbjct: 784 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 843
Query: 1422 DAE----QRSIYNMSVEVTD--GT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISED 1472
D E Q + VE D GT +A V +K D ND P FS+ Y ++ D
Sbjct: 844 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 901
Query: 1473 VLPDTEILQIEATDRDEKHKLSYTVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEA 1528
+ T I + A D D + V +D + F ++ +G + T L+ E
Sbjct: 902 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 961
Query: 1529 QDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQ 1587
L ++ D P + A V + V + P FT Y V E A G+ V
Sbjct: 962 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGV 1020
Query: 1588 VTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIK----- 1642
++A N ++Y+I +GN + F I + G+I + D T +VL ++
Sbjct: 1021 ISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1076
Query: 1643 --VTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST 1700
+ + P S TA V I + +N P F K Y V+E+ + TSV+ + A + T
Sbjct: 1077 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1136
Query: 1701 ----------LIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATN--MAG 1748
+I +K+G F + Y+G+I T R S ++ + AT+ G
Sbjct: 1137 GNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1194
Query: 1749 MASNATVNIQIVDEND 1764
++ A V + +V++ D
Sbjct: 1195 LSGKADVLVSVVNQLD 1210
Score = 197 bits (502), Expect = 2e-49
Identities = 274/1148 (23%), Positives = 487/1148 (42%), Gaps = 173/1148 (15%)
Query: 998 LDYEKQQ-FYNLTVRAKDKGRPVSLSSVS--------------FVEVEVVDVNENLHTPY 1042
+D KQ F N T R D+ P+++ S+ + EV +V + N ++P
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPT 146
Query: 1043 FPDFAVVGSVKENSRIGTSVL-----QVTARDEDSGRDGEIQYSIR----DGSGLGRFSI 1093
F + +V E + +GT++ A D D G +G+I+Y I+ D +
Sbjct: 147 FKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNE 206
Query: 1094 DDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
+ D+LD + +G +L + V + D PLT Y
Sbjct: 207 RRTTTTTLTVDVLDGDDLGPMFLPC-----------------VLVPNTRDCRPLT----Y 245
Query: 1154 YPVVME-NSPKDVSVI----QIQAEDPD-----SSSNEKLTYRITSGNPQN---FFAINI 1200
+ E +P++++ I IQA D D S + Y I G P++ FF ++
Sbjct: 246 QAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHP 305
Query: 1201 KT---GLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEK 1257
+T L+ +R D Q+ + ++ +G P P + + +++LDEN+ P F
Sbjct: 306 RTAELSLLEPVNR--DFHQKFDLVIKAEQDNGHPLPAFAGLH--IEILDENNQSPYFTMP 361
Query: 1258 VYQIKLPE--------RDRKKRGEPIYRAFAFDRD--EGPNAEISYSIVDGNDDGKFFID 1307
YQ + E D P+ R A D+D + + E+ + ND F
Sbjct: 362 SYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSVFTV 417
Query: 1308 PKTGMVS--------SRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIP 1359
+TG+ R++ ++ I V Q+S ++I+ + +P
Sbjct: 418 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGV-----QESEPVIVNIQVMDANDNTPTF 472
Query: 1360 LTFDEPFYNFTVME-SDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIA 1418
Y +T M D V ++ V + + +N + ++I+ G F K G I IA
Sbjct: 473 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIA 531
Query: 1419 KPLDAEQRSIYNMSVEVTDGTNVA-----VTQVFIKVL-DNNDNGPEFSQPNYDVTISED 1472
++ Y ++V+ D A + V+I+VL NN + P F Q Y + ISE
Sbjct: 532 PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 591
Query: 1473 VLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKH 1532
+ +L ++ATDR E ++Y + + R F + +TG+L + LD E+ D++
Sbjct: 592 MRVGAVLLNLQATDR-EGDSITYAIE---NGDPQRVFNLSETTGILTLGKALDRESTDRY 647
Query: 1533 ILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPL-YEASVFESAALGSAVLQVTAL 1591
IL I D P + A V + V D ND++P F L SV E A + V QV A
Sbjct: 648 ILIITASDGR-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKAT 705
Query: 1592 DKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPM 1651
D D G N ++ Y++ GN N+F+I I T K + + L + TD P
Sbjct: 706 DPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPR 762
Query: 1652 SATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAIS---QSTLIYEVKDG 1708
+T + I V D++ P F + Y V EN+ GT+++ I A + + Y ++
Sbjct: 763 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSP 822
Query: 1709 DINGIFTINPYSGVITTQKALDYE----RTSSYQLIIQATNMAGM--ASNATVNIQIVDE 1762
++ F ++P++G ++ ++LDYE + +S +++A ++ G ATV + + D
Sbjct: 823 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDM 882
Query: 1763 NDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPL-VIRATDAD-----SNRNALLVYQIV 1816
ND PVF Y G ++ A + +P+ + A DAD ++R V +
Sbjct: 883 NDYPPVFSKRIYKGMVAPDA--------VKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 934
Query: 1817 ESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNI----- 1871
F V+ +G + T NL+ E F V D G P +++ + V++ +
Sbjct: 935 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE 994
Query: 1872 --EVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS-LD 1928
T PP ++ + T VGV +SA + + + YS++ G+ D
Sbjct: 995 IPRFTQEEYRPPPVSE-----LATKGTMVGV----ISA----AAINQSIVYSIVSGNEED 1041
Query: 1929 HFLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGKFY----------STSMVTIMVKEAM 1976
F I++ +GV+ + + ++ Y+L V+ + +T+ V I +++
Sbjct: 1042 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1101
Query: 1977 DSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLN--EPLKYSILNPGNK-----FKIK 2029
+ F + FY +SE+ T V V A + Y ++ P K F ++
Sbjct: 1102 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1161
Query: 2030 STSGVIQT 2037
+ +G+I+T
Sbjct: 1162 TYTGLIKT 1169
Score = 186 bits (473), Expect = 4e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 316 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 375
Query: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 376 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 435
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 436 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 486
Query: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 487 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 538
Query: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 539 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 598
Query: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 599 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 658
Query: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 659 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 713
Query: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 714 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 769
Query: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 770 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 829
Query: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
L+P +G L L +SL + + + A D P ++V+
Sbjct: 830 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 878
Query: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
+N P F K + V D G
Sbjct: 879 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 906
Query: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 907 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 966
Query: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 967 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1025
Query: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 1026 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1078
Query: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 1079 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1138
Query: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 1139 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1198
Query: 1017 RPVSLSSVSFVEVEVVDVN 1035
V +S V+ ++++V+ N
Sbjct: 1199 ADVLVSVVNQLDMQVIVSN 1217
Score = 174 bits (441), Expect = 2e-42
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 432 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 490
Query: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 491 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 550
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
N + + +Y+ + N +P + + V ++
Sbjct: 551 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 607
Query: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 608 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 660
Query: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 661 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 720
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 721 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 779
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 780 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 837
Query: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 838 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 895
Query: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 896 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 947
Query: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 948 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 989
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
L G + P F + V E G + I A + N
Sbjct: 990 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1029
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 1030 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1089
Query: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 1090 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1149
Query: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 1150 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1209
Query: 929 VNDCSPAFIPSSYSVKVLEDL 949
+ +P + K +EDL
Sbjct: 1210 DMQVIVSNVPPTLVEKKIEDL 1230
Score = 161 bits (407), Expect = 2e-38
Identities = 271/1110 (24%), Positives = 449/1110 (40%), Gaps = 171/1110 (15%)
Query: 142 TKVNIQVLDMNDLRPLF------------SPTTYSVTIAE-STPLRTSVAQVT----ATD 184
T + + VLD +DL P+F P TY I E TP + VT A D
Sbjct: 212 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 271
Query: 185 ADIGSN------GEFYYYFKNKVD----LFSVHPTSGVISLSGRLNYDEKNRYDLEILAV 234
D G Y + F +HP + +SL +N D ++DL I
Sbjct: 272 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI--- 328
Query: 235 DRGMKLYGNNGVSSTAKLYVHIERINEH--APTIHVVTHVPFSLEKEPTYA--------- 283
K +NG A +HIE ++E+ +P + ++ + LE P A
Sbjct: 329 ----KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLT 384
Query: 284 ----VVTVD-DLDDGANGEIESVSIVAGDPLDQFFLAKEG--KWLNEYKIKERKQIDWES 336
+V +D D++D + E+ + D F + + G ++L + +R++
Sbjct: 385 SPLRIVALDKDIEDTKDPELH---LFLNDYTSVFTVTQTGITRYLTLLQPVDREE----- 436
Query: 337 FPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVA 396
Y ++ A D G + + + + + D P F + YDV + PG +
Sbjct: 437 -QQTYTFSITAFD-GVQESEPVIVNIQVMD-ANDNTP-TFPEISYDVYVYTDMRPG--DS 490
Query: 397 IVKLSPEPID------VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNK 450
+++L+ D + Y++ G F IN +GLI A + + Y L V
Sbjct: 491 VIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAA 549
Query: 451 EGDLKAQ-----VTISIE---DANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKG 502
+ A+ T+ IE N P F Q +Y ++E++ VG +L + A+D+
Sbjct: 550 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR--- 606
Query: 503 ENGYITYSIASLN-LLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESE 561
E ITY+I + + F +++ TG+++ + LD ES+ + Y I+ ASD G P S
Sbjct: 607 EGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST-DRYILIITASD-GRP-DGTST 663
Query: 562 VNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNEL 621
V I + +VNDN+P+F+ + + + + V A D D + GN
Sbjct: 664 ATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN 723
Query: 622 GFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
F + + + K N +++ + L + ATDG +H + S+ +
Sbjct: 724 NLFRITSNGSIYTAVK--LNREVRD-YYELVVVATDG------------AVHPRHSTLT- 767
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
LA K+L I+ P F S V V+E+LP
Sbjct: 768 ----------LAIKVL-------------------DIDDNSPVFTNS-TYTVLVEENLPA 797
Query: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNI 801
G IL+I+A D D G N V + I F + TG+L +L +D E +I
Sbjct: 798 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 855
Query: 802 TI----YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARD 857
T +D+ +T+ V+D ND PVF + Y + + GT I V A D
Sbjct: 856 TFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 915
Query: 858 KDLGS--NGEVTYSVLTDTQ------QFAINSSTGIVYVADQLDRESKANYSLKIEARDK 909
D V Y V D Q F + +G V L+ E + L + A D
Sbjct: 916 ADPPGLPASRVRYRV-DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD 974
Query: 910 AESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPV-GTVIAWLETHDPDLGLG 968
E + S T+K+ + + P F Y + +L GT++ + +
Sbjct: 975 GE--PVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA----AAIN 1027
Query: 969 GQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD------KGRPVSL 1021
+ YS+V+ + F I+ +G I ++ LDYE + Y L V+A R S
Sbjct: 1028 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1087
Query: 1022 SSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYS 1081
S+ + V +E+ D EN H P F +G V E++R+ TSVL+V A D+D+G + Y
Sbjct: 1088 SNTAKVYIEIQD--ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1145
Query: 1082 I---RDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEV 1138
+ G F ++ +G+I A + + V ATD L +V + V
Sbjct: 1146 LIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSV 1205
Query: 1139 EDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
+ D + S P ++E +D++ I
Sbjct: 1206 VNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1233
Score = 129 bits (323), Expect = 9e-29
Identities = 135/568 (23%), Positives = 248/568 (43%), Gaps = 87/568 (15%)
Query: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
Query: 3165 KVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTI 3224
++ Y +I P D ++ + N + ++ TT+T+
Sbjct: 186 QIEY------------------VIQYNPDDPDRAQNLN-----------ERRTTTTTLTV 216
Query: 3225 TVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLAVFATSKDI 3265
VLD +D P+F RD Y +PE +P T + ++I
Sbjct: 217 DVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 276
Query: 3266 GTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTP 3319
++ I Y I G + F ++P+T +S+ E ++ + ++F LV++A+
Sbjct: 277 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 336
Query: 3320 ALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV-----------ILLIAEDV 3368
L A A ++I + D N+ P F+ Y I E A VG ++ I+ + +D+
Sbjct: 337 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 396
Query: 3369 DSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAM 3426
+ + ++H + D + FTV + + + + +DRE Y+ + A D G+
Sbjct: 397 EDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQE- 452
Query: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
S VNI + D NDN+P F +Y + + G S++QL D D NG ++ I
Sbjct: 453 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE-ITYEI 511
Query: 3487 LSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY--IRVRVIEE 3544
L G + + + G++ A + Y L VQA D+ P + ++ + + V+
Sbjct: 512 LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 571
Query: 3545 STHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKSLFKVNSHD 3602
+ P P ++ + + + G V+ + ATD++ D +T+A+++ + + +F ++
Sbjct: 572 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETT 630
Query: 3603 GKIIALG-GLD---SGKYVLNVSVSDGR 3626
G I+ LG LD + +Y+L ++ SDGR
Sbjct: 631 G-ILTLGKALDRESTDRYILIITASDGR 657
Score = 102 bits (253), Expect = 1e-20
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 468 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 521
Query: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 522 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 577
Query: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 578 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 633
Query: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 634 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 687
Query: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 688 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 743
Query: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 744 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 796
Query: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 797 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 856
Query: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 857 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 914
Query: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 915 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 973
Query: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 974 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1030
Query: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 1031 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1079
Query: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
+ +V SKS N +++ N P F K F
Sbjct: 1080 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1113
Query: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 1114 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1170
Query: 787 M 787
M
Sbjct: 1171 M 1171
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 1021 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1078
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1079 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1138
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1139 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1193
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1194 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1232
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 293 bits (750), Expect = 3e-78
Identities = 213/650 (32%), Positives = 325/650 (50%), Gaps = 58/650 (8%)
Query: 723 PYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDM---- 778
P + S P + + P+ + A D D+GFNG + + +G S F +D+
Sbjct: 145 PVINISIPENTLINSRFPIPS------ATDPDTGFNGVQHYELLNGQ--SVFGLDIVETP 196
Query: 779 ---ETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDS 835
+ QL V +DRE D Y++ I + D G PQKSS +L + V D NDN PVF +
Sbjct: 197 EGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQ 256
Query: 836 YSVNILESSGIGTEIIQVEARDKDLGSNGEVTY----SVLTDTQQ-FAINSSTGIVYVAD 890
V+I E++ +GT +IQ+ A D D+GSN E+ Y V T++ FA+N++TG++ V
Sbjct: 257 VEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQR 316
Query: 891 QLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP------AFIPSSYSVK 944
LDRE A + + + A D G + T+ + + DVND P P + +V
Sbjct: 317 SLDREETAIHKVTVLASD----GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVY 372
Query: 945 VLEDLPVGTVIAWLETHDPDLGLGG--------QVRYSLVNDYNGRFEIDKASGAIRLSK 996
+ E PV T IA + D D + G +V + L Y+ ++ ++ +S
Sbjct: 373 LSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS------- 425
Query: 997 ELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENS 1056
LDYE + ++ + A D G+P SL+ + V V++ D N+N P F + SV EN+
Sbjct: 426 LLDYEGTKEFSFKIVASDSGKP-SLNQTALVRVKLEDENDN--PPIFNQPVIELSVSENN 482
Query: 1057 RIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWL 1116
R G + ++A DEDSG++ +I Y + G F +D ++GV+TA+ + DRE +
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIF 540
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPD 1176
TV A D G PL S V + V D NDN+P + + V EN PK +V I D D
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD 600
Query: 1177 SSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQS 1236
+ N+ +T I + N F ++ +G+I ++ DREQQ+ + +V TDGG P+ S
Sbjct: 601 AGENKAVTLSILNDNDN--FVLDPYSGVI-KSNVSFDREQQSSYTFDVKATDGGQPPRSS 657
Query: 1237 TIWVVVQVLDENDNKPQF--PEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYS 1294
T V + V+D NDN P P KL G + FA D D G NAE+ Y+
Sbjct: 658 TAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYT 716
Query: 1295 IVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDI--LTIKAVDNGRPQKSST 1342
IV GN+ G F IDP TG ++ ++ + L + D G P+ T
Sbjct: 717 IVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHT 766
Score = 266 bits (681), Expect = 3e-70
Identities = 231/783 (29%), Positives = 374/783 (47%), Gaps = 70/783 (8%)
Query: 2825 EGMPVGT--KLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKD-- 2880
E +P+G K + I+ G + + Y L S + +++ + S+TG I T +
Sbjct: 36 ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVK---VSSSTGEIFTTSNRI 92
Query: 2881 ----------LDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYR 2930
E + F VV + F L ++ V D NDNAP+F V
Sbjct: 93 DREKLCAGASYAEENECFFELEVVILP-NDFFRLIKIKII---VKDTNDNAPMFPSPVIN 148
Query: 2931 GNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQS----EW-KVY 2985
++ E+ + S D DT N Y + G + F L +V++ +W ++
Sbjct: 149 ISIPENTLINSRFPIPSATDPDTG-FNGVQHYELLNG--QSVFGLDIVETPEGEKWPQLI 205
Query: 2986 VKRPLDREEQDIYFLNITATDG---LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDI 3042
V++ LDRE++D Y + I DG + A+++V+VSDVNDN PV + +PE+
Sbjct: 206 VQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENA 265
Query: 3043 PSNKIILKVSAKDADIGSNGYIRYSLYGSGNSE-----FFLDPESGELKTLALLDRERIP 3097
P ++++ A DADIGSN IRY ++G+ + F L+ +G + LDRE
Sbjct: 266 PVGTSVIQLHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLITVQRSLDREETA 324
Query: 3098 VYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHY----NTCVY----ENTATKAL 3149
++ + A+DG ++ + + + DVNDNPP + N VY + TK
Sbjct: 325 IHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIA 384
Query: 3150 LTRVQAVDPDIG------INRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNI 3203
L V D D+ I R+V + L + +++SS LD E ++
Sbjct: 385 LITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS-------LLDYEGTKEFSF 437
Query: 3204 SVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSK 3263
+ A+D S SL+ V + + D NDNPP+F + ++V E+ G + + AT +
Sbjct: 438 KIVASD-SGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDE 496
Query: 3264 DIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSA 3323
D G NA+I Y + G F ++ KTG ++ S V D E +RF V A+D GTP L +
Sbjct: 497 DSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQS 554
Query: 3324 VATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNG 3383
A V + + D NDN PKF+ + + +SE+ +V ++ D D+ N + SI+N
Sbjct: 555 QAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILN- 613
Query: 3384 DRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNS 3443
D DN F +DP G++K DRE+ S Y+ V+A D G P SSTA V I++ DVNDNS
Sbjct: 614 DNDN-FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNS 672
Query: 3444 P-VFTPANYTA--VIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDP- 3499
P V +P + T+ ++ + G+ + ++ D D+ N ++I+SGN + F +DP
Sbjct: 673 PVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA-ELKYTIVSGNNKGLFRIDPV 731
Query: 3500 HGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIV 3559
G + T+ + L V D G P+ + HT + V + T + ++
Sbjct: 732 TGNITLEEKPAPTDVGLHRLVVNISDLGYPKSL-HTLVLVFLYVNDTAGNASYIYDLIRR 790
Query: 3560 TME 3562
TME
Sbjct: 791 TME 793
Score = 248 bits (634), Expect = 8e-65
Identities = 198/676 (29%), Positives = 307/676 (45%), Gaps = 40/676 (5%)
Query: 2793 DIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYS 2852
D + + I V D NDN P+F + + I E + ++ A D D G NG Y
Sbjct: 121 DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYE 180
Query: 2853 LHSDSQPEKVMEAFNIDSNTGW--ISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALV 2910
L + Q ++ W + ++LD E T+ + D G SSTA++
Sbjct: 181 L-LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVED-GGTPQKSSTAIL 238
Query: 2911 SVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN-- 2968
V V+D+NDN PVF + ++ E+ P G V L D D N ++ Y I G
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGS-NAEIRY-IFGAQVA 296
Query: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFV-TQAMVEVSVSDVNDNSP 3027
P + L + + V+R LDREE I+ + + A+DG +A V ++V+DVNDN P
Sbjct: 297 PATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPP 356
Query: 3028 ------VCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNG--------YIRYSLYGSGN 3073
+ + T L E P N I ++ D D NG + + L +
Sbjct: 357 NIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYD 416
Query: 3074 SEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSN--IHLILEDVNDNPPVF 3131
+++ L+ T +LLD E +S A+D G + + LED NDNPP+F
Sbjct: 417 NQYLLE-------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF 469
Query: 3132 SSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQ 3191
+ V EN LT + A D D G N +VY L +A F +D +G++ +
Sbjct: 470 NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASR 528
Query: 3192 PLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSP 3251
DRE+Q + +V A D L S V +TVLD NDN P F + V E+
Sbjct: 529 VFDREEQERFIFTVTARDNGT-PPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPK 587
Query: 3252 GTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVV 3311
+ V + T D G N +T I + N+ F ++P +G I + D E + V
Sbjct: 588 YSTVGVITVTDADAGENKAVTLSILNDND--NFVLDPYSGVIKSNVSFDREQQSSYTFDV 645
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKF---SQDVYSAVISEDALVGDSVILLIAEDV 3368
+A DGG P S+ A V IN+ DVNDN P + ++ A+ G V + A DV
Sbjct: 646 KATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDV 705
Query: 3369 DSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIP-AMS 3427
D+ N ++ ++IV+G+ F +DPV G + +++K V + L+V D G P ++
Sbjct: 706 DTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLH 765
Query: 3428 STATVNIDISDVNDNS 3443
+ V + ++D N+
Sbjct: 766 TLVLVFLYVNDTAGNA 781
Score = 239 bits (610), Expect = 5e-62
Identities = 190/679 (27%), Positives = 330/679 (48%), Gaps = 61/679 (8%)
Query: 1510 RIDPSTGVLYT-AERLDHE--------AQDKHI---LNIMVRDQEFPYRRNLARVIVNVE 1557
++ STG ++T + R+D E A++ L +++ +F L ++ + V+
Sbjct: 77 KVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDF---FRLIKIKIIVK 133
Query: 1558 DANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIE 1617
D ND++P F +P+ S+ E+ + S +A D D G N Y + G + +F ++
Sbjct: 134 DTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS--VFGLD 191
Query: 1618 PV-------LGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPK 1670
V + + + D +V+ IKV D G+P S+TAI++++V+ +++ P
Sbjct: 192 IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251
Query: 1671 FIHKDYQAEVNENVDIGTSVILISA----ISQSTLIYEVKDGDI----NGIFTINPYSGV 1722
F + + EN +GTSVI + A I + I + + +F +N +G+
Sbjct: 252 FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGL 311
Query: 1723 ITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAP----VFLFSQYSGS- 1777
IT Q++LD E T+ +++ + A++ + + ATV I + D NDN P ++ S +G+
Sbjct: 312 ITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTV 371
Query: 1778 -LSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTI 1836
LSE P+N+ + +I +D D++ N ++ I V + + T
Sbjct: 372 YLSEKDPVNTKI-------ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETS 424
Query: 1837 ANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPT 1896
+ LD+E F F + DSG P L + V V +E D NDNPP+F Q V E +
Sbjct: 425 SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLE--DENDNPPIFNQPVIELSVSENN 482
Query: 1897 YVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKN--NNLSKDHYMLI 1954
G+ + +SATD DS ++ Y L + F +D +GVLT + ++ ++
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1955 VKVSDG---KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL 2011
V D S + V + V + D+ FT + + +SEN + V ++
Sbjct: 542 VTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADA 601
Query: 2012 --NEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVV 2069
N+ + SILN + F + SGVI+ + V FDRE+Q Y V+A+ R +
Sbjct: 602 GENKAVTLSILNDNDNFVLDPYSGVIK-SNVSFDREQQSSYTFDVKATDGGQPPRSSTAK 660
Query: 2070 VRVNIEDINDNSPVFVGLP---YYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY--VLQ 2124
V +N+ D+NDNSPV + P + V + A PG+++ +V A+D D G N E+ Y V
Sbjct: 661 VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 2125 DDYGHFEINPNSGNVILKE 2143
++ G F I+P +GN+ L+E
Sbjct: 721 NNKGLFRIDPVTGNITLEE 739
Score = 237 bits (605), Expect = 2e-61
Identities = 182/645 (28%), Positives = 291/645 (45%), Gaps = 39/645 (6%)
Query: 817 LTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ 876
+ I V+D NDN+P+F +++I E++ I + A D D G NG Y +L
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 877 FAIN-------SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDV 929
F ++ + V LDRE K Y +KI+ D Q S L+V + DV
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGT--PQKSSTAILQVTVSDV 245
Query: 930 NDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRY----SLVNDYNGRFEI 985
ND P F V + E+ PVGT + L D D+G ++RY + F +
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 986 DKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPD 1045
+ +G I + + LD E+ + +TV A D S + + V + V DVN+N P D
Sbjct: 306 NNTTGLITVQRSLDREETAIHKVTVLASDGS---STPARATVTINVTDVNDN---PPNID 359
Query: 1046 FAVVGS-------VKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESG 1098
+ S + E + T + +T D+D+ +G++ I ++ D
Sbjct: 360 LRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQY 419
Query: 1099 VITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVM 1158
++ + +LD E + + A+D G L T V +++ED NDN P+ ++P+ V
Sbjct: 420 LLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVS 479
Query: 1159 ENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQA 1218
EN+ + + + I A D DS N + Y++ G +FF ++ KTG++ T SR DRE+Q
Sbjct: 480 ENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVL-TASRVFDREEQE 536
Query: 1219 EHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRA 1278
VT D G P QS V+V VLDENDN P+F +Q + E K +
Sbjct: 537 RFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT- 595
Query: 1279 FAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILT--IKAVDNGR 1336
D D G N ++ SI++ ND+ F +DP +G++ S F T +KA D G+
Sbjct: 596 -VTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQ 652
Query: 1337 PQKSSTARLHIEWIKKPPPSPI----PLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTP 1392
P +SSTA++ I + SP+ P + + V E+ V N
Sbjct: 653 PPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAE 712
Query: 1393 LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD 1437
L + IV GN F + G I + + ++ + V ++D
Sbjct: 713 LKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 234 bits (597), Expect = 1e-60
Identities = 212/680 (31%), Positives = 298/680 (43%), Gaps = 57/680 (8%)
Query: 2691 LIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST---------------VDTLRILPS 2735
LI + I V P F + +I E+T I S V +L
Sbjct: 125 LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184
Query: 2736 QNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIV 2795
Q+V F E PE K +++Q LDRE + K+
Sbjct: 185 QSV-FGLDIVETPEGEKWPQLIVQQN---------LDREQKDTYVMKIKVEDG-GTPQKS 233
Query: 2796 FTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHS 2855
T + + V D+NDN+PVF+ + I E PVGT + Q+ A D D G+N ++ Y +
Sbjct: 234 STAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGA 293
Query: 2856 DSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVT 2915
P F +++ TG I+ + LD E +V+ASD S + A V++ VT
Sbjct: 294 QVAP-ATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD---GSSTPARATVTINVT 349
Query: 2916 DINDNAP----VFAQEVYRGNV--KESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNP 2969
D+NDN P + G V E DP +A+++ D+DT DVN +V I P
Sbjct: 350 DVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDT-DVNGKVICFIEREVP 408
Query: 2970 RGRFALGLV-QSEWKVYVKRPLDREEQDIYFLNITATDG---LFVTQAMVEVSVSDVNDN 3025
F L V +++ + LD E + I A+D A+V V + D NDN
Sbjct: 409 ---FHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDN 465
Query: 3026 SPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGEL 3085
P+ +Q + E+ + +SA D D G N I Y L G S F LD ++G L
Sbjct: 466 PPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL-GPNASFFDLDRKTGVL 524
Query: 3086 KTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYEN 3143
+ DRE + A D G QS +I+ D NDN P F+ +H+ V EN
Sbjct: 525 TASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSEN 584
Query: 3144 TATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNI 3203
+ + + D D G N+ V S+ + F +D SG+I DREQQSSY
Sbjct: 585 LPKYSTVGVITVTDADAGENKAVTLSILNDNDN-FVLDPYSGVIKSNVSFDREQQSSYTF 643
Query: 3204 SVRATD--QSPGQSLSSLTTVTITVLDINDNPPVF---ERRDYLVTVPEDTSPGTQVLAV 3258
V+ATD Q P SS VTI V+D+NDN PV VP PG+ V V
Sbjct: 644 DVKATDGGQPP---RSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEV 700
Query: 3259 FATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGT 3318
FA D G NAE+ Y I SGN +G F+I+P TG I++ E LVV D G
Sbjct: 701 FAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGY 760
Query: 3319 P-ALSAVATVNINLTDVNDN 3337
P +L + V + + D N
Sbjct: 761 PKSLHTLVLVFLYVNDTAGN 780
Score = 231 bits (589), Expect = 1e-59
Identities = 190/661 (28%), Positives = 312/661 (47%), Gaps = 49/661 (7%)
Query: 1027 VEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
+++ V D N+N P FP + S+ EN+ I + +A D D+G +G Y + +G
Sbjct: 128 IKIIVKDTNDN--APMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQ 185
Query: 1087 GLGRFSID-------DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVE 1139
+ F +D ++ + LDRE +Y + + D G ST + + V
Sbjct: 186 SV--FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVS 243
Query: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
DVNDN P+ E + EN+P SVIQ+ A D D SN ++ Y + + F
Sbjct: 244 DVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 1197 AINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPE 1256
A+N TGLIT R LDRE+ A H + V +DG +P ++T V + V D NDN P
Sbjct: 304 ALNNTTGLITV-QRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDL 360
Query: 1257 KVYQIKLPERDRKKRGEPIYRAFAF----DRDEGPNAEISYSI-------VDGNDDGKFF 1305
+ + +P+ A D+D N ++ I + D ++
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYL 420
Query: 1306 IDPKTGM-VSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDE 1364
++ + + K+F+ I A D+G+P + TA + ++ + PI F++
Sbjct: 421 LETSSLLDYEGTKEFS------FKIVASDSGKPSLNQTALVRVKLEDENDNPPI---FNQ 471
Query: 1365 PFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVG--GNFDSAFDAEKGVGTIVIAKPLD 1422
P +V E++R + +S ++ DIV G S FD ++ G + ++ D
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFD 531
Query: 1423 AEQRSIYNMSVEVTD-GTNVAVTQ--VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEI 1479
E++ + +V D GT +Q V + VLD NDN P+F+ ++ +SE++ + +
Sbjct: 532 REEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV 591
Query: 1480 LQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVR 1539
I TD D + T+ D+ + F +DP +GV+ + D E Q + ++
Sbjct: 592 GVITVTDADAGENKAVTLSILNDNDN---FVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648
Query: 1540 DQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEAS---VFESAALGSAVLQVTALDKDKG 1596
D P R + A+V +NV D ND+SP +P S V SA GS V +V A+D D G
Sbjct: 649 DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG 708
Query: 1597 ENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAI 1656
NAEL YTI +GN +F+I+PV G IT+ ++P T +G L + ++D G P T +
Sbjct: 709 MNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Query: 1657 V 1657
+
Sbjct: 769 L 769
Score = 225 bits (573), Expect = 9e-58
Identities = 215/787 (27%), Positives = 360/787 (45%), Gaps = 85/787 (10%)
Query: 861 GSNGEVTYSVLT---DTQQFAINSSTGIVYV-ADQLDRE---SKANYSLKIEARDKAES- 912
G++ + Y +++ D ++SSTG ++ ++++DRE + A+Y+ + E + E
Sbjct: 57 GTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVV 116
Query: 913 --GQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQ 970
F ++ +K+ + D ND +P F ++ + E+ + + DPD G G
Sbjct: 117 ILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGV 176
Query: 971 VRYSLVNDYN--GRFEIDKASG----AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSV 1024
Y L+N + G ++ G + + + LD E++ Y + ++ +D G P SS
Sbjct: 177 QHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP-QKSST 235
Query: 1025 SFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD 1084
+ ++V V DVN+N P F + V + EN+ +GTSV+Q+ A D D G + EI+Y
Sbjct: 236 AILQVTVSDVNDN--RPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIF-- 291
Query: 1085 GSGLG-----RFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVE 1139
G+ + F++++ +G+IT LDRE + +TV A+D P +T V I V
Sbjct: 292 GAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT--VTINVT 349
Query: 1140 DVNDNAP-LTSEPIYYPV-----VMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQ 1193
DVNDN P + I P+ + E P + + I D D+ N K+ I P
Sbjct: 350 DVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPF 409
Query: 1194 NFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQ 1253
+ A+ L+ T+S LD E E ++ +D G T V V++ DENDN P
Sbjct: 410 HLKAVYDNQYLLETSS-LLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPI 468
Query: 1254 FPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMV 1313
F + V ++ + E +R RG + A D D G NA+I Y + G + F +D KTG++
Sbjct: 469 FNQPVIELSVSENNR--RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVL 524
Query: 1314 SSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTV 1371
++ + F + I T+ A DNG P S A + + + + SP F + F V
Sbjct: 525 TASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSP---KFTHNHFQFFV 581
Query: 1372 MESDRVTEIVGVVSVQPA----NTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRS 1427
E+ VGV++V A N + I+ N + D GV I D EQ+S
Sbjct: 582 SENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGV--IKSNVSFDREQQS 639
Query: 1428 IYNMSVEVTDG---TNVAVTQVFIKVLDNNDNGPEFSQPNYDVT---ISEDVLPDTEILQ 1481
Y V+ TDG + +V I V+D NDN P P + + + +P + + +
Sbjct: 640 SYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAE 699
Query: 1482 IEATDRDE--KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVR 1539
+ A D D +L YT+ + + FRIDP TG NI +
Sbjct: 700 VFAVDVDTGMNAELKYTI---VSGNNKGLFRIDPVTG------------------NITLE 738
Query: 1540 DQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQV------TALDK 1593
++ P L R++VN+ D T L V ++A S + + T LD+
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDR 798
Query: 1594 DKGENAE 1600
+ G++++
Sbjct: 799 NIGDSSQ 805
Score = 222 bits (566), Expect = 6e-57
Identities = 216/787 (27%), Positives = 354/787 (44%), Gaps = 74/787 (9%)
Query: 1134 VYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITS-GNP 1192
+Y E++ +N P+ N PKD+++ I A S+S L YR+ S
Sbjct: 27 IYTIREELPENVPIG-----------NIPKDLNISHINAATGTSAS---LVYRLVSKAGD 72
Query: 1193 QNFFAINIKTGLITTTSRKLDRE---------QQAEHFLEVTVTDGGPSPKQSTIWVVVQ 1243
++ TG I TTS ++DRE ++ E F E+ V P+ I + +
Sbjct: 73 APLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVIL-PNDFFRLIKIKII 131
Query: 1244 VLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDD-G 1302
V D NDN P FP V I +PE PI A D D G N Y +++G G
Sbjct: 132 VKDTNDNAPMFPSPVINISIPENTLINSRFPI--PSATDPDTGFNGVQHYELLNGQSVFG 189
Query: 1303 KFFIDPKTG------MVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPS 1356
++ G +V ++ IK D G PQKSSTA L +
Sbjct: 190 LDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNR 249
Query: 1357 PIPLTFDEPFYNFTVMESDRV-TEIVGVVSVQP---ANTPLWFDIVGGNFDSA----FDA 1408
P+ F E + E+ V T ++ + + +N + + I G A F
Sbjct: 250 PV---FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRY-IFGAQVAPATKRLFAL 305
Query: 1409 EKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNV-AVTQVFIKVLDNNDNGPEF------S 1461
G I + + LD E+ +I+ ++V +DG++ A V I V D NDN P S
Sbjct: 306 NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIIS 365
Query: 1462 QPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSID-SISMRKFRIDPSTGVLYT 1520
N V +SE +T+I I +D+D ++ V I+ + + + +L T
Sbjct: 366 PINGTVYLSEKDPVNTKIALITVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 1521 AERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAA 1580
+ LD+E + I+ D P A V V +ED ND+ P F P+ E SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 1581 LGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLS 1640
G + ++A D+D G+NA+++Y + G + F ++ G++T + D +F+ +
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1641 IKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI---- 1696
+ D G+PP+ + A V ++V +++ PKF H +Q V+EN+ ++V +I+
Sbjct: 542 VTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADA 601
Query: 1697 --SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASN 1752
+++ + + D D F ++PYSGVI + + D E+ SSY ++AT+ +S
Sbjct: 602 GENKAVTLSILNDND---NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSST 658
Query: 1753 ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLV 1812
A V I ++D NDN+PV + S S + + P+++I S+ + A D D+ NA L
Sbjct: 659 AKVTINVMDVNDNSPV-VISPPSNTSFKLVPLSAIPGSV---VAEVFAVDVDTGMNAELK 714
Query: 1813 YQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIE 1872
Y IV K F +D TG I + V++ D G P+ + + V V +
Sbjct: 715 YTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPK-SLHTLVLVFLY 773
Query: 1873 VTDVNDN 1879
V D N
Sbjct: 774 VNDTAGN 780
Score = 214 bits (546), Expect = 1e-54
Identities = 205/719 (28%), Positives = 338/719 (47%), Gaps = 68/719 (9%)
Query: 2027 KIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVA--------RVVVRVNIEDIN 2078
K+ S++G I TT DRE+ E + L V + +++ ++D N
Sbjct: 77 KVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTN 136
Query: 2079 DNSPVFVGLPYYAAVQVDAEPGTLIYQ----VTAIDKDKGPNGEVTYVL---QDDYGHFE 2131
DN+P+F + + TLI +A D D G NG Y L Q +G
Sbjct: 137 DNAPMFPS----PVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDI 192
Query: 2132 INPNSGN----VILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI--VNKAMPV 2185
+ G +I+++ + + + Y + I +DGG P S++ L +T+ VN PV
Sbjct: 193 VETPEGEKWPQLIVQQNLDREQKDT-YVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251
Query: 2186 FDKPFYTASVNEDIRMNTPILSINATSPE---GQGIIYII---IDGDPFKQFNIDFDTGV 2239
F + + E+ + T ++ ++AT + I YI + + F ++ TG+
Sbjct: 252 FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGL 311
Query: 2240 LKVVSPLDYEVTSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFD-----QPTYN 2293
+ V LD E T+ +K+T+ ASD + T ARA VT++ V DVNDNPP D P
Sbjct: 312 ITVQRSLDREETAIHKVTVLASDGSSTPARATVTIN--VTDVNDNPPNIDLRYIISPING 369
Query: 2294 TT-LSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDS---SSGLILTA 2349
T LSE + T + + D D++ N V I ++ FH+ + + L+ T+
Sbjct: 370 TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP-----FHLKAVYDNQYLLETS 424
Query: 2350 RMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPR 2409
+LD+E + + K+ + DSG PSL+ LV + + D NDNPP+FNQ + E VSE R
Sbjct: 425 SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRR 484
Query: 2410 GHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNV 2469
G ++T + A+D DS + Y + G + + F +D K+GV+T S + + + V
Sbjct: 485 GLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTV 542
Query: 2470 SVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPG 2526
+ D S A V + VL N SP F+ + + V EN+ + V + TD D G
Sbjct: 543 TARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAG 602
Query: 2527 TYGQISYAIINDFAKDRFLIDS-NGQVITTERLDRENPLEGDVSIFVRALDGG--GRTTF 2583
++ +I+ND D F++D +G + + DRE + + V+A DGG R++
Sbjct: 603 ENKAVTLSILND--NDNFVLDPYSGVIKSNVSFDREQ--QSSYTFDVKATDGGQPPRSST 658
Query: 2584 CTVRVIVVDENDNAPQFMTVEYRAS---VRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
V + V+D NDN+P ++ S V G +V +V A+D D G N+ + Y++
Sbjct: 659 AKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVK-HSLIPVYIHV 2698
S + L IDP G + + + V D G P H+L+ V+++V
Sbjct: 719 SGNN---KGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYV 774
Score = 199 bits (505), Expect = 7e-50
Identities = 183/674 (27%), Positives = 291/674 (43%), Gaps = 41/674 (6%)
Query: 2271 VTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDT 2330
+ + ++V D NDN P+F P N ++ E +LI + + D D+ N + HY+++
Sbjct: 126 IKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELL--- 182
Query: 2331 YNSTDYFHID-------SSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIY 2383
N F +D ++ + LD E +K++ D G P SS ++ +
Sbjct: 183 -NGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241
Query: 2384 ISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSI---LSGNDRT 2440
+SDVNDN PVF + E ++ E AP G V + A+DAD + Y ++ +
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
Query: 2441 SFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFT-STAQVHIRVLGANLYSPAFSQS 2499
F +++ +G+IT+ + ++ + V SDG T + A V I V N P
Sbjct: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLR 361
Query: 2500 TYVAEVRENV------AAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVI 2553
++ + V TK+ + +D D G++ I + + N ++
Sbjct: 362 YIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL 421
Query: 2554 -TTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRAD 2612
T+ LD E E I VRV + DENDN P F SV +
Sbjct: 422 ETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN 481
Query: 2613 VGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNT 2672
RG +T + A D D G N+ I Y L AS ++D G + F++ +
Sbjct: 482 NRRGLYLTTISATDEDSGKNADIVYQLGPNAS-----FFDLDRKTGVLTASRVFDREEQE 536
Query: 2673 VLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRI 2732
F V A D G P S V + VL P FT + + F ++E+ STV + +
Sbjct: 537 RFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITV 596
Query: 2733 LPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKV 2792
+ V +N FV++ +G IK + DRE ++ F V AT +
Sbjct: 597 TDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKAT-DGGQP 653
Query: 2793 DIVFTVDVDIKVLDLNDNKPVF----ETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQ 2848
T V I V+D+NDN PV +S+ + + +P G+ + +V A+D+D G N +
Sbjct: 654 PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAE 712
Query: 2849 VTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVV-ASDLGEAFSLSST 2907
+ Y++ S + F ID TG I TL++ TD VV SDLG SL +
Sbjct: 713 LKYTIVSGNN----KGLFRIDPVTGNI-TLEEKPAPTDVGLHRLVVNISDLGYPKSLHTL 767
Query: 2908 ALVSVRVTDINDNA 2921
LV + V D NA
Sbjct: 768 VLVFLYVNDTAGNA 781
Score = 191 bits (486), Expect = 1e-47
Identities = 164/587 (27%), Positives = 295/587 (50%), Gaps = 58/587 (9%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKV-NIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
L+RE +D Y++ +K G ++ T + + V D+ND RP+F V I E+ P+ T
Sbjct: 210 LDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGT 269
Query: 176 SVAQVTATDADIGSNGEFYYYFKNKV-----DLFSVHPTSGVISLSGRLNYDEKNRYDLE 230
SV Q+ ATDADIGSN E Y F +V LF+++ T+G+I++ L+ +E + +
Sbjct: 270 SVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVT 329
Query: 231 ILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHV------VTHVPFSLEKEPT--- 281
+LA D + + A + +++ +N++ P I + + + EK+P
Sbjct: 330 VLASD-------GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTK 382
Query: 282 YAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGY 341
A++TV D D NG++ I + F L + + N+Y ++ +D+E +
Sbjct: 383 IALITVSDKDTDVNGKV----ICFIEREVPFHL--KAVYDNQYLLETSSLLDYEG-TKEF 435
Query: 342 NLTLQAKDKGSPQ-KCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKL 400
+ + A D G P +AL V + D PI F + V ++S+SE + G+ + +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKL-EDENDNPPI-FNQPVIELSVSENNRRGLYLTTISA 493
Query: 401 SPEP----IDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG---- 452
+ E D+ Y+L P +A +F ++ ++G++ +R + ++E + VT ++
Sbjct: 494 TDEDSGKNADIVYQLGP--NASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP 551
Query: 453 -DLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI 511
+A V +++ D ND++P+F + +V+E++P ++V ++ +D D GEN +T SI
Sbjct: 552 LQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSI 611
Query: 512 ASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNV 571
+ N FV++ ++GVI + D E Y F V+A+D G P R S VTI + +V
Sbjct: 612 LNDN-DNFVLDPYSGVIKSNVSFDREQQSS-YTFDVKATDGGQPPR-SSTAKVTINVMDV 668
Query: 572 NDNSPLFEKVACQ---GVISYDFPVGGHITAVSAIDID---ELELVKYKIISGNELGFFY 625
NDNSP+ ++ G + V A+D+D EL KY I+SGN G F
Sbjct: 669 NDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL-KYTIVSGNNKGLFR 727
Query: 626 LNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVL 672
++P +G + L++ + + + I+ +L P S++ VL
Sbjct: 728 IDPVTGNITLEEKPAPTDVGLHRLVVNIS-----DLGYPKSLHTLVL 769
Score = 164 bits (414), Expect = 2e-39
Identities = 193/777 (24%), Positives = 342/777 (44%), Gaps = 78/777 (10%)
Query: 1679 EVNENVDIGT-------SVILISAISQSTLIYEV--KDGDINGIFTINPYSGVITTQKAL 1729
E+ ENV IG S I + + ++L+Y + K GD + + + TT +
Sbjct: 33 ELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRI 92
Query: 1730 DYERT---SSY----------QLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSG 1776
D E+ +SY +++I + + + I + D NDNAP+F S
Sbjct: 93 DREKLCAGASYAEENECFFELEVVILPNDFFRLIK---IKIIVKDTNDNAPMFP----SP 145
Query: 1777 SLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAK-KFFTVDSSTGA--- 1832
++ + P N+++ S P ATD D+ N + Y+++ + V++ G
Sbjct: 146 VINISIPENTLINSRFPIP---SATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWP 202
Query: 1833 -IRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETI 1891
+ NLD E + + V D G+PQ ++ + ++V V+DVNDN PVF + E
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT--VSDVNDNRPVFKEGQVEVH 260
Query: 1892 LLLPTYVGVEVLKVSATDPDSEVPPELTY----SLMEGSLDHFLIDSNSGVLTIKNNNLS 1947
+ VG V+++ ATD D E+ Y + + F +++ +G++T++ + L
Sbjct: 261 IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRS-LD 319
Query: 1948 KDH---YMLIVKVSDGKFY-STSMVTIMVKEAMDSGLHFTQSFYSTSI------SENNTN 1997
++ + + V SDG + + VTI V + D+ + + + I SE +
Sbjct: 320 REETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPV 379
Query: 1998 ITKVAIVNAVGNRLNEPLKY-SILNPGNKFKIKST--SGVIQTTGVPFDREEQELYELVV 2054
TK+A++ + K + F +K+ + + T D E + + +
Sbjct: 380 NTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKI 439
Query: 2055 EASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKG 2114
AS +VRV +ED NDN P+F +V + G + ++A D+D G
Sbjct: 440 VASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSG 499
Query: 2115 PNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVEL 2174
N ++ Y L + F+++ +G + F+ + + T+ A+D G P L + +
Sbjct: 500 KNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQE-RFIFTVTARDNGTPPLQSQAAV 558
Query: 2175 PITIV--NKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE-GQG---IIYIIIDGDPF 2228
+T++ N P F + V+E++ + + I T + G+ + I+ D D
Sbjct: 559 IVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDND-- 616
Query: 2229 KQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGAR---AEVTVDLLVNDVNDNPP 2285
F +D +GV+K D E S+Y ++A+D R A+VT++++ DVNDN P
Sbjct: 617 -NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVM--DVNDNSP 673
Query: 2286 IFDQPTYNTTLSEASLIGTP---VLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSS 2342
+ P NT+ L P V +V ++D D+ N + Y IV N+ F ID
Sbjct: 674 VVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG--NNKGLFRIDPV 731
Query: 2343 SGLILTARMLDHELVQHCTLKVRSIDSGFP-SLSSEVLVHIYISDVNDNPPVFNQLI 2398
+G I V L V D G+P SL + VLV +Y++D N LI
Sbjct: 732 TGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLI 788
Score = 155 bits (392), Expect = 9e-37
Identities = 139/491 (28%), Positives = 220/491 (44%), Gaps = 42/491 (8%)
Query: 3114 QSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADS 3173
Q I+ I E++ +N P+ + + N AT G + +VY L
Sbjct: 24 QELIYTIREELPENVPIGNIPKDLNISHINAAT--------------GTSASLVYRLVSK 69
Query: 3174 AGG--VFSIDSSSG-IIILEQPLDREQQ---SSYNISVRATDQSPGQSLSS----LTTVT 3223
AG + + SS+G I +DRE+ +SY + L + L +
Sbjct: 70 AGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIK 129
Query: 3224 ITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGK 3283
I V D NDN P+F +++PE+T ++ AT D G N Y + +G
Sbjct: 130 IIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFG 189
Query: 3284 FKINPKTGG-----ISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNP 3338
I G + V + LD E + + ++ +DGGTP S+ A + + ++DVNDN
Sbjct: 190 LDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNR 249
Query: 3339 PKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSI---VNGDRDNEFTVDPVL 3395
P F + I E+A VG SVI L A D D N +I + V F ++
Sbjct: 250 PVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTT 309
Query: 3396 GLVKVKKKLDRERVSGYSLLVQAVD-SGIPAMSSTATVNIDISDVNDNSP------VFTP 3448
GL+ V++ LDRE + + + V A D S PA ATV I+++DVNDN P + +P
Sbjct: 310 GLITVQRSLDREETAIHKVTVLASDGSSTPAR---ATVTINVTDVNDNPPNIDLRYIISP 366
Query: 3449 ANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPHGILRSAVV 3508
N T + E PV T I + V+D+D+ NG F + V D +L ++ +
Sbjct: 367 INGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSL 426
Query: 3509 FQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGG 3568
+ + E+ + A DSGKP +RV++ +E+ + P I + E++ G
Sbjct: 427 LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGL 486
Query: 3569 VIGKIHATDQD 3579
+ I ATD+D
Sbjct: 487 YLTTISATDED 497
Score = 143 bits (361), Expect = 3e-33
Identities = 162/691 (23%), Positives = 286/691 (41%), Gaps = 78/691 (11%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD 202
K+ I V D ND P+F +++I E+T + + +ATD D G NG +Y N
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 203 LFS---VHPTSG----VISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVH 255
+F V G + + L+ ++K+ Y ++I D G SSTA L V
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDG-----GTPQKSSTAILQVT 241
Query: 256 IERINEHAPTI---HVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQF 312
+ +N++ P V H+P + + + D D G+N EI + P +
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
Query: 313 FLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTV 372
A I ++ +D E L + +P + + V N +
Sbjct: 302 LFALNN---TTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNI 358
Query: 373 PIRFEKEVYD--VSISEFSPPGVVVAIVKLSPEPIDVEYKL---SPGEDAVYFK-INPRS 426
+R+ + V +SE P +A++ +S + DV K+ E + K +
Sbjct: 359 DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ 418
Query: 427 GLIVTARPLNTVKKEVYKLEVTNKEG-----DLKAQVTISIEDANDHTPEFQQPLYDAYV 481
L+ T+ L+ + + ++ + + A V + +ED ND+ P F QP+ + V
Sbjct: 419 YLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSV 478
Query: 482 NESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPE 541
+E+ G + T+SA+D+D G+N I Y + N F +++ TGV++ + D E E
Sbjct: 479 SENNRRGLYLTTISATDEDSGKNADIVYQLGP-NASFFDLDRKTGVLTASRVFDREEQ-E 536
Query: 542 IYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVS 601
+ F V A D G+P +S+ V + + + NDNSP F Q +S + P + ++
Sbjct: 537 RFIFTVTARDNGTP-PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT 595
Query: 602 AIDID--ELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE 659
D D E + V I++ N+ F L+P SGV +K +++ + ++ + ATDG
Sbjct: 596 VTDADAGENKAVTLSILNDND--NFVLDPYSGV--IKSNVSFDREQQSSYTFDVKATDGG 651
Query: 660 NLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSIN 719
+ +++ V+ S ++I +N L
Sbjct: 652 QPPRSSTAKVTINVMDVNDNS--------------PVVISPPSNTSFKL----------- 686
Query: 720 RQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME 779
V G+ + ++ A D D+G N ++ +TI GN F ID
Sbjct: 687 ---------------VPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPV 731
Query: 780 TGQLKVLMPMDREHTDLYLLNITIYDLGNPQ 810
TG + + L+ L + I DLG P+
Sbjct: 732 TGNITLEEKPAPTDVGLHRLVVNISDLGYPK 762
Score = 78.6 bits (192), Expect = 1e-13
Identities = 70/271 (25%), Positives = 122/271 (45%), Gaps = 26/271 (9%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEV--IIADFCFLR 106
N ++ V+ +R G+ L +S + DE+ A+ V + + F
Sbjct: 465 NPPIFNQPVIELSVSENNRRGLYLTTIS--------ATDEDSGKNADIVYQLGPNASFFD 516
Query: 107 IRTKGG---NSAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFSPTT 162
+ K G S + +RE Q+ ++ V G L++ V + VLD ND P F+
Sbjct: 517 LDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNH 576
Query: 163 YSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYD 222
+ ++E+ P ++V +T TDAD G N N D F + P SGVI + + +
Sbjct: 577 FQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDRE 636
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTI------HVVTHVPFSL 276
+++ Y ++ A D G SSTAK+ +++ +N+++P + VP S
Sbjct: 637 QQSSYTFDVKATDGGQP-----PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 277 EKEPTYAVVTVDDLDDGANGEIESVSIVAGD 307
A V D+D G N E++ +IV+G+
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELK-YTIVSGN 721
Score = 53.9 bits (128), Expect = 4e-06
Identities = 53/211 (25%), Positives = 92/211 (43%), Gaps = 20/211 (9%)
Query: 3432 VNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNE 3491
+ I + D NDN+P+F I EN + + TD D+ NG + +L+G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQH-YELLNG-- 184
Query: 3492 EEEFVLD----PHGILRSAVVFQHTESLE----YVLCVQAKDSGKPQQVSHTYIRVRVIE 3543
+ F LD P G ++ Q E YV+ ++ +D G PQ+ S ++V V +
Sbjct: 185 QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSD 244
Query: 3544 ESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYD------VLTFALKSEQKSLFK 3597
+ ++P ++ + E+ G + ++HATD D+ + + K LF
Sbjct: 245 VNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 3598 VNSHDGKIIALGGLD---SGKYVLNVSVSDG 3625
+N+ G I LD + + + V SDG
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDG 335
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 293 bits (750), Expect = 3e-78
Identities = 213/650 (32%), Positives = 325/650 (50%), Gaps = 58/650 (8%)
Query: 723 PYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDM---- 778
P + S P + + P+ + A D D+GFNG + + +G S F +D+
Sbjct: 145 PVINISIPENTLINSRFPIPS------ATDPDTGFNGVQHYELLNGQ--SVFGLDIVETP 196
Query: 779 ---ETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDS 835
+ QL V +DRE D Y++ I + D G PQKSS +L + V D NDN PVF +
Sbjct: 197 EGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQ 256
Query: 836 YSVNILESSGIGTEIIQVEARDKDLGSNGEVTY----SVLTDTQQ-FAINSSTGIVYVAD 890
V+I E++ +GT +IQ+ A D D+GSN E+ Y V T++ FA+N++TG++ V
Sbjct: 257 VEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQR 316
Query: 891 QLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP------AFIPSSYSVK 944
LDRE A + + + A D G + T+ + + DVND P P + +V
Sbjct: 317 SLDREETAIHKVTVLASD----GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVY 372
Query: 945 VLEDLPVGTVIAWLETHDPDLGLGG--------QVRYSLVNDYNGRFEIDKASGAIRLSK 996
+ E PV T IA + D D + G +V + L Y+ ++ ++ +S
Sbjct: 373 LSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS------- 425
Query: 997 ELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENS 1056
LDYE + ++ + A D G+P SL+ + V V++ D N+N P F + SV EN+
Sbjct: 426 LLDYEGTKEFSFKIVASDSGKP-SLNQTALVRVKLEDENDN--PPIFNQPVIELSVSENN 482
Query: 1057 RIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWL 1116
R G + ++A DEDSG++ +I Y + G F +D ++GV+TA+ + DRE +
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIF 540
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPD 1176
TV A D G PL S V + V D NDN+P + + V EN PK +V I D D
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDAD 600
Query: 1177 SSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQS 1236
+ N+ +T I + N F ++ +G+I ++ DREQQ+ + +V TDGG P+ S
Sbjct: 601 AGENKAVTLSILNDNDN--FVLDPYSGVI-KSNVSFDREQQSSYTFDVKATDGGQPPRSS 657
Query: 1237 TIWVVVQVLDENDNKPQF--PEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYS 1294
T V + V+D NDN P P KL G + FA D D G NAE+ Y+
Sbjct: 658 TAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYT 716
Query: 1295 IVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDI--LTIKAVDNGRPQKSST 1342
IV GN+ G F IDP TG ++ ++ + L + D G P+ T
Sbjct: 717 IVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHT 766
Score = 266 bits (681), Expect = 3e-70
Identities = 231/783 (29%), Positives = 374/783 (47%), Gaps = 70/783 (8%)
Query: 2825 EGMPVGT--KLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKD-- 2880
E +P+G K + I+ G + + Y L S + +++ + S+TG I T +
Sbjct: 36 ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVK---VSSSTGEIFTTSNRI 92
Query: 2881 ----------LDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYR 2930
E + F VV + F L ++ V D NDNAP+F V
Sbjct: 93 DREKLCAGASYAEENECFFELEVVILP-NDFFRLIKIKII---VKDTNDNAPMFPSPVIN 148
Query: 2931 GNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQS----EW-KVY 2985
++ E+ + S D DT N Y + G + F L +V++ +W ++
Sbjct: 149 ISIPENTLINSRFPIPSATDPDTG-FNGVQHYELLNG--QSVFGLDIVETPEGEKWPQLI 205
Query: 2986 VKRPLDREEQDIYFLNITATDG---LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDI 3042
V++ LDRE++D Y + I DG + A+++V+VSDVNDN PV + +PE+
Sbjct: 206 VQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENA 265
Query: 3043 PSNKIILKVSAKDADIGSNGYIRYSLYGSGNSE-----FFLDPESGELKTLALLDRERIP 3097
P ++++ A DADIGSN IRY ++G+ + F L+ +G + LDRE
Sbjct: 266 PVGTSVIQLHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLITVQRSLDREETA 324
Query: 3098 VYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHY----NTCVY----ENTATKAL 3149
++ + A+DG ++ + + + DVNDNPP + N VY + TK
Sbjct: 325 IHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIA 384
Query: 3150 LTRVQAVDPDIG------INRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNI 3203
L V D D+ I R+V + L + +++SS LD E ++
Sbjct: 385 LITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS-------LLDYEGTKEFSF 437
Query: 3204 SVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSK 3263
+ A+D S SL+ V + + D NDNPP+F + ++V E+ G + + AT +
Sbjct: 438 KIVASD-SGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDE 496
Query: 3264 DIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSA 3323
D G NA+I Y + G F ++ KTG ++ S V D E +RF V A+D GTP L +
Sbjct: 497 DSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQS 554
Query: 3324 VATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNG 3383
A V + + D NDN PKF+ + + +SE+ +V ++ D D+ N + SI+N
Sbjct: 555 QAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILN- 613
Query: 3384 DRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNS 3443
D DN F +DP G++K DRE+ S Y+ V+A D G P SSTA V I++ DVNDNS
Sbjct: 614 DNDN-FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNS 672
Query: 3444 P-VFTPANYTA--VIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDP- 3499
P V +P + T+ ++ + G+ + ++ D D+ N ++I+SGN + F +DP
Sbjct: 673 PVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA-ELKYTIVSGNNKGLFRIDPV 731
Query: 3500 HGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIV 3559
G + T+ + L V D G P+ + HT + V + T + ++
Sbjct: 732 TGNITLEEKPAPTDVGLHRLVVNISDLGYPKSL-HTLVLVFLYVNDTAGNASYIYDLIRR 790
Query: 3560 TME 3562
TME
Sbjct: 791 TME 793
Score = 248 bits (634), Expect = 8e-65
Identities = 198/676 (29%), Positives = 307/676 (45%), Gaps = 40/676 (5%)
Query: 2793 DIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYS 2852
D + + I V D NDN P+F + + I E + ++ A D D G NG Y
Sbjct: 121 DFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYE 180
Query: 2853 LHSDSQPEKVMEAFNIDSNTGW--ISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALV 2910
L + Q ++ W + ++LD E T+ + D G SSTA++
Sbjct: 181 L-LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVED-GGTPQKSSTAIL 238
Query: 2911 SVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN-- 2968
V V+D+NDN PVF + ++ E+ P G V L D D N ++ Y I G
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGS-NAEIRY-IFGAQVA 296
Query: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFV-TQAMVEVSVSDVNDNSP 3027
P + L + + V+R LDREE I+ + + A+DG +A V ++V+DVNDN P
Sbjct: 297 PATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPP 356
Query: 3028 ------VCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNG--------YIRYSLYGSGN 3073
+ + T L E P N I ++ D D NG + + L +
Sbjct: 357 NIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYD 416
Query: 3074 SEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSN--IHLILEDVNDNPPVF 3131
+++ L+ T +LLD E +S A+D G + + LED NDNPP+F
Sbjct: 417 NQYLLE-------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF 469
Query: 3132 SSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQ 3191
+ V EN LT + A D D G N +VY L +A F +D +G++ +
Sbjct: 470 NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASR 528
Query: 3192 PLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSP 3251
DRE+Q + +V A D L S V +TVLD NDN P F + V E+
Sbjct: 529 VFDREEQERFIFTVTARDNGT-PPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPK 587
Query: 3252 GTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVV 3311
+ V + T D G N +T I + N+ F ++P +G I + D E + V
Sbjct: 588 YSTVGVITVTDADAGENKAVTLSILNDND--NFVLDPYSGVIKSNVSFDREQQSSYTFDV 645
Query: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKF---SQDVYSAVISEDALVGDSVILLIAEDV 3368
+A DGG P S+ A V IN+ DVNDN P + ++ A+ G V + A DV
Sbjct: 646 KATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDV 705
Query: 3369 DSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIP-AMS 3427
D+ N ++ ++IV+G+ F +DPV G + +++K V + L+V D G P ++
Sbjct: 706 DTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLH 765
Query: 3428 STATVNIDISDVNDNS 3443
+ V + ++D N+
Sbjct: 766 TLVLVFLYVNDTAGNA 781
Score = 239 bits (610), Expect = 5e-62
Identities = 190/679 (27%), Positives = 330/679 (48%), Gaps = 61/679 (8%)
Query: 1510 RIDPSTGVLYT-AERLDHE--------AQDKHI---LNIMVRDQEFPYRRNLARVIVNVE 1557
++ STG ++T + R+D E A++ L +++ +F L ++ + V+
Sbjct: 77 KVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDF---FRLIKIKIIVK 133
Query: 1558 DANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIE 1617
D ND++P F +P+ S+ E+ + S +A D D G N Y + G + +F ++
Sbjct: 134 DTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS--VFGLD 191
Query: 1618 PV-------LGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPK 1670
V + + + D +V+ IKV D G+P S+TAI++++V+ +++ P
Sbjct: 192 IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251
Query: 1671 FIHKDYQAEVNENVDIGTSVILISA----ISQSTLIYEVKDGDI----NGIFTINPYSGV 1722
F + + EN +GTSVI + A I + I + + +F +N +G+
Sbjct: 252 FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGL 311
Query: 1723 ITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAP----VFLFSQYSGS- 1777
IT Q++LD E T+ +++ + A++ + + ATV I + D NDN P ++ S +G+
Sbjct: 312 ITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTV 371
Query: 1778 -LSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTI 1836
LSE P+N+ + +I +D D++ N ++ I V + + T
Sbjct: 372 YLSEKDPVNTKI-------ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETS 424
Query: 1837 ANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPT 1896
+ LD+E F F + DSG P L + V V +E D NDNPP+F Q V E +
Sbjct: 425 SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLE--DENDNPPIFNQPVIELSVSENN 482
Query: 1897 YVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKN--NNLSKDHYMLI 1954
G+ + +SATD DS ++ Y L + F +D +GVLT + ++ ++
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1955 VKVSDG---KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL 2011
V D S + V + V + D+ FT + + +SEN + V ++
Sbjct: 542 VTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADA 601
Query: 2012 --NEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVV 2069
N+ + SILN + F + SGVI+ + V FDRE+Q Y V+A+ R +
Sbjct: 602 GENKAVTLSILNDNDNFVLDPYSGVIK-SNVSFDREQQSSYTFDVKATDGGQPPRSSTAK 660
Query: 2070 VRVNIEDINDNSPVFVGLP---YYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY--VLQ 2124
V +N+ D+NDNSPV + P + V + A PG+++ +V A+D D G N E+ Y V
Sbjct: 661 VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 2125 DDYGHFEINPNSGNVILKE 2143
++ G F I+P +GN+ L+E
Sbjct: 721 NNKGLFRIDPVTGNITLEE 739
Score = 237 bits (605), Expect = 2e-61
Identities = 182/645 (28%), Positives = 291/645 (45%), Gaps = 39/645 (6%)
Query: 817 LTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ 876
+ I V+D NDN+P+F +++I E++ I + A D D G NG Y +L
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 877 FAIN-------SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDV 929
F ++ + V LDRE K Y +KI+ D Q S L+V + DV
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGT--PQKSSTAILQVTVSDV 245
Query: 930 NDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRY----SLVNDYNGRFEI 985
ND P F V + E+ PVGT + L D D+G ++RY + F +
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 986 DKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPD 1045
+ +G I + + LD E+ + +TV A D S + + V + V DVN+N P D
Sbjct: 306 NNTTGLITVQRSLDREETAIHKVTVLASDGS---STPARATVTINVTDVNDN---PPNID 359
Query: 1046 FAVVGS-------VKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESG 1098
+ S + E + T + +T D+D+ +G++ I ++ D
Sbjct: 360 LRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQY 419
Query: 1099 VITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVM 1158
++ + +LD E + + A+D G L T V +++ED NDN P+ ++P+ V
Sbjct: 420 LLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVS 479
Query: 1159 ENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQA 1218
EN+ + + + I A D DS N + Y++ G +FF ++ KTG++ T SR DRE+Q
Sbjct: 480 ENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVL-TASRVFDREEQE 536
Query: 1219 EHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRA 1278
VT D G P QS V+V VLDENDN P+F +Q + E K +
Sbjct: 537 RFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT- 595
Query: 1279 FAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILT--IKAVDNGR 1336
D D G N ++ SI++ ND+ F +DP +G++ S F T +KA D G+
Sbjct: 596 -VTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQ 652
Query: 1337 PQKSSTARLHIEWIKKPPPSPI----PLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTP 1392
P +SSTA++ I + SP+ P + + V E+ V N
Sbjct: 653 PPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAE 712
Query: 1393 LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD 1437
L + IV GN F + G I + + ++ + V ++D
Sbjct: 713 LKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 234 bits (597), Expect = 1e-60
Identities = 212/680 (31%), Positives = 298/680 (43%), Gaps = 57/680 (8%)
Query: 2691 LIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST---------------VDTLRILPS 2735
LI + I V P F + +I E+T I S V +L
Sbjct: 125 LIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG 184
Query: 2736 QNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIV 2795
Q+V F E PE K +++Q LDRE + K+
Sbjct: 185 QSV-FGLDIVETPEGEKWPQLIVQQN---------LDREQKDTYVMKIKVEDG-GTPQKS 233
Query: 2796 FTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHS 2855
T + + V D+NDN+PVF+ + I E PVGT + Q+ A D D G+N ++ Y +
Sbjct: 234 STAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGA 293
Query: 2856 DSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVT 2915
P F +++ TG I+ + LD E +V+ASD S + A V++ VT
Sbjct: 294 QVAP-ATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD---GSSTPARATVTINVT 349
Query: 2916 DINDNAP----VFAQEVYRGNV--KESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNP 2969
D+NDN P + G V E DP +A+++ D+DT DVN +V I P
Sbjct: 350 DVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDT-DVNGKVICFIEREVP 408
Query: 2970 RGRFALGLV-QSEWKVYVKRPLDREEQDIYFLNITATDG---LFVTQAMVEVSVSDVNDN 3025
F L V +++ + LD E + I A+D A+V V + D NDN
Sbjct: 409 ---FHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDN 465
Query: 3026 SPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGEL 3085
P+ +Q + E+ + +SA D D G N I Y L G S F LD ++G L
Sbjct: 466 PPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL-GPNASFFDLDRKTGVL 524
Query: 3086 KTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYEN 3143
+ DRE + A D G QS +I+ D NDN P F+ +H+ V EN
Sbjct: 525 TASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSEN 584
Query: 3144 TATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNI 3203
+ + + D D G N+ V S+ + F +D SG+I DREQQSSY
Sbjct: 585 LPKYSTVGVITVTDADAGENKAVTLSILNDNDN-FVLDPYSGVIKSNVSFDREQQSSYTF 643
Query: 3204 SVRATD--QSPGQSLSSLTTVTITVLDINDNPPVF---ERRDYLVTVPEDTSPGTQVLAV 3258
V+ATD Q P SS VTI V+D+NDN PV VP PG+ V V
Sbjct: 644 DVKATDGGQPP---RSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEV 700
Query: 3259 FATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGT 3318
FA D G NAE+ Y I SGN +G F+I+P TG I++ E LVV D G
Sbjct: 701 FAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGY 760
Query: 3319 P-ALSAVATVNINLTDVNDN 3337
P +L + V + + D N
Sbjct: 761 PKSLHTLVLVFLYVNDTAGN 780
Score = 231 bits (589), Expect = 1e-59
Identities = 190/661 (28%), Positives = 312/661 (47%), Gaps = 49/661 (7%)
Query: 1027 VEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
+++ V D N+N P FP + S+ EN+ I + +A D D+G +G Y + +G
Sbjct: 128 IKIIVKDTNDN--APMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQ 185
Query: 1087 GLGRFSID-------DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVE 1139
+ F +D ++ + LDRE +Y + + D G ST + + V
Sbjct: 186 SV--FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVS 243
Query: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
DVNDN P+ E + EN+P SVIQ+ A D D SN ++ Y + + F
Sbjct: 244 DVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 1197 AINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPE 1256
A+N TGLIT R LDRE+ A H + V +DG +P ++T V + V D NDN P
Sbjct: 304 ALNNTTGLITV-QRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDL 360
Query: 1257 KVYQIKLPERDRKKRGEPIYRAFAF----DRDEGPNAEISYSI-------VDGNDDGKFF 1305
+ + +P+ A D+D N ++ I + D ++
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYL 420
Query: 1306 IDPKTGM-VSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDE 1364
++ + + K+F+ I A D+G+P + TA + ++ + PI F++
Sbjct: 421 LETSSLLDYEGTKEFS------FKIVASDSGKPSLNQTALVRVKLEDENDNPPI---FNQ 471
Query: 1365 PFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVG--GNFDSAFDAEKGVGTIVIAKPLD 1422
P +V E++R + +S ++ DIV G S FD ++ G + ++ D
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFD 531
Query: 1423 AEQRSIYNMSVEVTD-GTNVAVTQ--VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEI 1479
E++ + +V D GT +Q V + VLD NDN P+F+ ++ +SE++ + +
Sbjct: 532 REEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV 591
Query: 1480 LQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVR 1539
I TD D + T+ D+ + F +DP +GV+ + D E Q + ++
Sbjct: 592 GVITVTDADAGENKAVTLSILNDNDN---FVLDPYSGVIKSNVSFDREQQSSYTFDVKAT 648
Query: 1540 DQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEAS---VFESAALGSAVLQVTALDKDKG 1596
D P R + A+V +NV D ND+SP +P S V SA GS V +V A+D D G
Sbjct: 649 DGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTG 708
Query: 1597 ENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAI 1656
NAEL YTI +GN +F+I+PV G IT+ ++P T +G L + ++D G P T +
Sbjct: 709 MNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Query: 1657 V 1657
+
Sbjct: 769 L 769
Score = 225 bits (573), Expect = 9e-58
Identities = 215/787 (27%), Positives = 360/787 (45%), Gaps = 85/787 (10%)
Query: 861 GSNGEVTYSVLT---DTQQFAINSSTGIVYV-ADQLDRE---SKANYSLKIEARDKAES- 912
G++ + Y +++ D ++SSTG ++ ++++DRE + A+Y+ + E + E
Sbjct: 57 GTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVV 116
Query: 913 --GQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQ 970
F ++ +K+ + D ND +P F ++ + E+ + + DPD G G
Sbjct: 117 ILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGV 176
Query: 971 VRYSLVNDYN--GRFEIDKASG----AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSV 1024
Y L+N + G ++ G + + + LD E++ Y + ++ +D G P SS
Sbjct: 177 QHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP-QKSST 235
Query: 1025 SFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD 1084
+ ++V V DVN+N P F + V + EN+ +GTSV+Q+ A D D G + EI+Y
Sbjct: 236 AILQVTVSDVNDN--RPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIF-- 291
Query: 1085 GSGLG-----RFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVE 1139
G+ + F++++ +G+IT LDRE + +TV A+D P +T V I V
Sbjct: 292 GAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT--VTINVT 349
Query: 1140 DVNDNAP-LTSEPIYYPV-----VMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQ 1193
DVNDN P + I P+ + E P + + I D D+ N K+ I P
Sbjct: 350 DVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPF 409
Query: 1194 NFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQ 1253
+ A+ L+ T+S LD E E ++ +D G T V V++ DENDN P
Sbjct: 410 HLKAVYDNQYLLETSS-LLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPI 468
Query: 1254 FPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMV 1313
F + V ++ + E +R RG + A D D G NA+I Y + G + F +D KTG++
Sbjct: 469 FNQPVIELSVSENNR--RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVL 524
Query: 1314 SSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTV 1371
++ + F + I T+ A DNG P S A + + + + SP F + F V
Sbjct: 525 TASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSP---KFTHNHFQFFV 581
Query: 1372 MESDRVTEIVGVVSVQPA----NTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRS 1427
E+ VGV++V A N + I+ N + D GV I D EQ+S
Sbjct: 582 SENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGV--IKSNVSFDREQQS 639
Query: 1428 IYNMSVEVTDG---TNVAVTQVFIKVLDNNDNGPEFSQPNYDVT---ISEDVLPDTEILQ 1481
Y V+ TDG + +V I V+D NDN P P + + + +P + + +
Sbjct: 640 SYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAE 699
Query: 1482 IEATDRDE--KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVR 1539
+ A D D +L YT+ + + FRIDP TG NI +
Sbjct: 700 VFAVDVDTGMNAELKYTI---VSGNNKGLFRIDPVTG------------------NITLE 738
Query: 1540 DQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQV------TALDK 1593
++ P L R++VN+ D T L V ++A S + + T LD+
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDR 798
Query: 1594 DKGENAE 1600
+ G++++
Sbjct: 799 NIGDSSQ 805
Score = 222 bits (566), Expect = 6e-57
Identities = 216/787 (27%), Positives = 354/787 (44%), Gaps = 74/787 (9%)
Query: 1134 VYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITS-GNP 1192
+Y E++ +N P+ N PKD+++ I A S+S L YR+ S
Sbjct: 27 IYTIREELPENVPIG-----------NIPKDLNISHINAATGTSAS---LVYRLVSKAGD 72
Query: 1193 QNFFAINIKTGLITTTSRKLDRE---------QQAEHFLEVTVTDGGPSPKQSTIWVVVQ 1243
++ TG I TTS ++DRE ++ E F E+ V P+ I + +
Sbjct: 73 APLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVIL-PNDFFRLIKIKII 131
Query: 1244 VLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDD-G 1302
V D NDN P FP V I +PE PI A D D G N Y +++G G
Sbjct: 132 VKDTNDNAPMFPSPVINISIPENTLINSRFPI--PSATDPDTGFNGVQHYELLNGQSVFG 189
Query: 1303 KFFIDPKTG------MVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPS 1356
++ G +V ++ IK D G PQKSSTA L +
Sbjct: 190 LDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNR 249
Query: 1357 PIPLTFDEPFYNFTVMESDRV-TEIVGVVSVQP---ANTPLWFDIVGGNFDSA----FDA 1408
P+ F E + E+ V T ++ + + +N + + I G A F
Sbjct: 250 PV---FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRY-IFGAQVAPATKRLFAL 305
Query: 1409 EKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNV-AVTQVFIKVLDNNDNGPEF------S 1461
G I + + LD E+ +I+ ++V +DG++ A V I V D NDN P S
Sbjct: 306 NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIIS 365
Query: 1462 QPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSID-SISMRKFRIDPSTGVLYT 1520
N V +SE +T+I I +D+D ++ V I+ + + + +L T
Sbjct: 366 PINGTVYLSEKDPVNTKIALITVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 1521 AERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAA 1580
+ LD+E + I+ D P A V V +ED ND+ P F P+ E SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 1581 LGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLS 1640
G + ++A D+D G+NA+++Y + G + F ++ G++T + D +F+ +
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1641 IKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI---- 1696
+ D G+PP+ + A V ++V +++ PKF H +Q V+EN+ ++V +I+
Sbjct: 542 VTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADA 601
Query: 1697 --SQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASN 1752
+++ + + D D F ++PYSGVI + + D E+ SSY ++AT+ +S
Sbjct: 602 GENKAVTLSILNDND---NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSST 658
Query: 1753 ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLV 1812
A V I ++D NDN+PV + S S + + P+++I S+ + A D D+ NA L
Sbjct: 659 AKVTINVMDVNDNSPV-VISPPSNTSFKLVPLSAIPGSV---VAEVFAVDVDTGMNAELK 714
Query: 1813 YQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIE 1872
Y IV K F +D TG I + V++ D G P+ + + V V +
Sbjct: 715 YTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPK-SLHTLVLVFLY 773
Query: 1873 VTDVNDN 1879
V D N
Sbjct: 774 VNDTAGN 780
Score = 214 bits (546), Expect = 1e-54
Identities = 205/719 (28%), Positives = 338/719 (47%), Gaps = 68/719 (9%)
Query: 2027 KIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVA--------RVVVRVNIEDIN 2078
K+ S++G I TT DRE+ E + L V + +++ ++D N
Sbjct: 77 KVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTN 136
Query: 2079 DNSPVFVGLPYYAAVQVDAEPGTLIYQ----VTAIDKDKGPNGEVTYVL---QDDYGHFE 2131
DN+P+F + + TLI +A D D G NG Y L Q +G
Sbjct: 137 DNAPMFPS----PVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDI 192
Query: 2132 INPNSGN----VILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI--VNKAMPV 2185
+ G +I+++ + + + Y + I +DGG P S++ L +T+ VN PV
Sbjct: 193 VETPEGEKWPQLIVQQNLDREQKDT-YVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251
Query: 2186 FDKPFYTASVNEDIRMNTPILSINATSPE---GQGIIYII---IDGDPFKQFNIDFDTGV 2239
F + + E+ + T ++ ++AT + I YI + + F ++ TG+
Sbjct: 252 FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGL 311
Query: 2240 LKVVSPLDYEVTSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFD-----QPTYN 2293
+ V LD E T+ +K+T+ ASD + T ARA VT++ V DVNDNPP D P
Sbjct: 312 ITVQRSLDREETAIHKVTVLASDGSSTPARATVTIN--VTDVNDNPPNIDLRYIISPING 369
Query: 2294 TT-LSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDS---SSGLILTA 2349
T LSE + T + + D D++ N V I ++ FH+ + + L+ T+
Sbjct: 370 TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP-----FHLKAVYDNQYLLETS 424
Query: 2350 RMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPR 2409
+LD+E + + K+ + DSG PSL+ LV + + D NDNPP+FNQ + E VSE R
Sbjct: 425 SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRR 484
Query: 2410 GHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNV 2469
G ++T + A+D DS + Y + G + + F +D K+GV+T S + + + V
Sbjct: 485 GLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTV 542
Query: 2470 SVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPG 2526
+ D S A V + VL N SP F+ + + V EN+ + V + TD D G
Sbjct: 543 TARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAG 602
Query: 2527 TYGQISYAIINDFAKDRFLIDS-NGQVITTERLDRENPLEGDVSIFVRALDGG--GRTTF 2583
++ +I+ND D F++D +G + + DRE + + V+A DGG R++
Sbjct: 603 ENKAVTLSILND--NDNFVLDPYSGVIKSNVSFDREQ--QSSYTFDVKATDGGQPPRSST 658
Query: 2584 CTVRVIVVDENDNAPQFMTVEYRAS---VRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
V + V+D NDN+P ++ S V G +V +V A+D D G N+ + Y++
Sbjct: 659 AKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718
Query: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVK-HSLIPVYIHV 2698
S + L IDP G + + + V D G P H+L+ V+++V
Sbjct: 719 SGNN---KGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYV 774
Score = 199 bits (505), Expect = 7e-50
Identities = 183/674 (27%), Positives = 291/674 (43%), Gaps = 41/674 (6%)
Query: 2271 VTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDT 2330
+ + ++V D NDN P+F P N ++ E +LI + + D D+ N + HY+++
Sbjct: 126 IKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELL--- 182
Query: 2331 YNSTDYFHID-------SSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIY 2383
N F +D ++ + LD E +K++ D G P SS ++ +
Sbjct: 183 -NGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241
Query: 2384 ISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSI---LSGNDRT 2440
+SDVNDN PVF + E ++ E AP G V + A+DAD + Y ++ +
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
Query: 2441 SFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFT-STAQVHIRVLGANLYSPAFSQS 2499
F +++ +G+IT+ + ++ + V SDG T + A V I V N P
Sbjct: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLR 361
Query: 2500 TYVAEVRENV------AAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVI 2553
++ + V TK+ + +D D G++ I + + N ++
Sbjct: 362 YIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL 421
Query: 2554 -TTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRAD 2612
T+ LD E E I VRV + DENDN P F SV +
Sbjct: 422 ETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN 481
Query: 2613 VGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNT 2672
RG +T + A D D G N+ I Y L AS ++D G + F++ +
Sbjct: 482 NRRGLYLTTISATDEDSGKNADIVYQLGPNAS-----FFDLDRKTGVLTASRVFDREEQE 536
Query: 2673 VLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRI 2732
F V A D G P S V + VL P FT + + F ++E+ STV + +
Sbjct: 537 RFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITV 596
Query: 2733 LPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKV 2792
+ V +N FV++ +G IK + DRE ++ F V AT +
Sbjct: 597 TDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKAT-DGGQP 653
Query: 2793 DIVFTVDVDIKVLDLNDNKPVF----ETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQ 2848
T V I V+D+NDN PV +S+ + + +P G+ + +V A+D+D G N +
Sbjct: 654 PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAE 712
Query: 2849 VTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVV-ASDLGEAFSLSST 2907
+ Y++ S + F ID TG I TL++ TD VV SDLG SL +
Sbjct: 713 LKYTIVSGNN----KGLFRIDPVTGNI-TLEEKPAPTDVGLHRLVVNISDLGYPKSLHTL 767
Query: 2908 ALVSVRVTDINDNA 2921
LV + V D NA
Sbjct: 768 VLVFLYVNDTAGNA 781
Score = 191 bits (486), Expect = 1e-47
Identities = 164/587 (27%), Positives = 295/587 (50%), Gaps = 58/587 (9%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKV-NIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
L+RE +D Y++ +K G ++ T + + V D+ND RP+F V I E+ P+ T
Sbjct: 210 LDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGT 269
Query: 176 SVAQVTATDADIGSNGEFYYYFKNKV-----DLFSVHPTSGVISLSGRLNYDEKNRYDLE 230
SV Q+ ATDADIGSN E Y F +V LF+++ T+G+I++ L+ +E + +
Sbjct: 270 SVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVT 329
Query: 231 ILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHV------VTHVPFSLEKEPT--- 281
+LA D + + A + +++ +N++ P I + + + EK+P
Sbjct: 330 VLASD-------GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTK 382
Query: 282 YAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGY 341
A++TV D D NG++ I + F L + + N+Y ++ +D+E +
Sbjct: 383 IALITVSDKDTDVNGKV----ICFIEREVPFHL--KAVYDNQYLLETSSLLDYEG-TKEF 435
Query: 342 NLTLQAKDKGSPQ-KCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKL 400
+ + A D G P +AL V + D PI F + V ++S+SE + G+ + +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKL-EDENDNPPI-FNQPVIELSVSENNRRGLYLTTISA 493
Query: 401 SPEP----IDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG---- 452
+ E D+ Y+L P +A +F ++ ++G++ +R + ++E + VT ++
Sbjct: 494 TDEDSGKNADIVYQLGP--NASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP 551
Query: 453 -DLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI 511
+A V +++ D ND++P+F + +V+E++P ++V ++ +D D GEN +T SI
Sbjct: 552 LQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSI 611
Query: 512 ASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNV 571
+ N FV++ ++GVI + D E Y F V+A+D G P R S VTI + +V
Sbjct: 612 LNDN-DNFVLDPYSGVIKSNVSFDREQQSS-YTFDVKATDGGQPPR-SSTAKVTINVMDV 668
Query: 572 NDNSPLFEKVACQ---GVISYDFPVGGHITAVSAIDID---ELELVKYKIISGNELGFFY 625
NDNSP+ ++ G + V A+D+D EL KY I+SGN G F
Sbjct: 669 NDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL-KYTIVSGNNKGLFR 727
Query: 626 LNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVL 672
++P +G + L++ + + + I+ +L P S++ VL
Sbjct: 728 IDPVTGNITLEEKPAPTDVGLHRLVVNIS-----DLGYPKSLHTLVL 769
Score = 164 bits (414), Expect = 2e-39
Identities = 193/777 (24%), Positives = 342/777 (44%), Gaps = 78/777 (10%)
Query: 1679 EVNENVDIGT-------SVILISAISQSTLIYEV--KDGDINGIFTINPYSGVITTQKAL 1729
E+ ENV IG S I + + ++L+Y + K GD + + + TT +
Sbjct: 33 ELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRI 92
Query: 1730 DYERT---SSY----------QLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSG 1776
D E+ +SY +++I + + + I + D NDNAP+F S
Sbjct: 93 DREKLCAGASYAEENECFFELEVVILPNDFFRLIK---IKIIVKDTNDNAPMFP----SP 145
Query: 1777 SLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAK-KFFTVDSSTGA--- 1832
++ + P N+++ S P ATD D+ N + Y+++ + V++ G
Sbjct: 146 VINISIPENTLINSRFPIP---SATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWP 202
Query: 1833 -IRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETI 1891
+ NLD E + + V D G+PQ ++ + ++V V+DVNDN PVF + E
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT--VSDVNDNRPVFKEGQVEVH 260
Query: 1892 LLLPTYVGVEVLKVSATDPDSEVPPELTY----SLMEGSLDHFLIDSNSGVLTIKNNNLS 1947
+ VG V+++ ATD D E+ Y + + F +++ +G++T++ + L
Sbjct: 261 IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRS-LD 319
Query: 1948 KDH---YMLIVKVSDGKFY-STSMVTIMVKEAMDSGLHFTQSFYSTSI------SENNTN 1997
++ + + V SDG + + VTI V + D+ + + + I SE +
Sbjct: 320 REETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPV 379
Query: 1998 ITKVAIVNAVGNRLNEPLKY-SILNPGNKFKIKST--SGVIQTTGVPFDREEQELYELVV 2054
TK+A++ + K + F +K+ + + T D E + + +
Sbjct: 380 NTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKI 439
Query: 2055 EASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKG 2114
AS +VRV +ED NDN P+F +V + G + ++A D+D G
Sbjct: 440 VASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSG 499
Query: 2115 PNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVEL 2174
N ++ Y L + F+++ +G + F+ + + T+ A+D G P L + +
Sbjct: 500 KNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQE-RFIFTVTARDNGTPPLQSQAAV 558
Query: 2175 PITIV--NKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE-GQG---IIYIIIDGDPF 2228
+T++ N P F + V+E++ + + I T + G+ + I+ D D
Sbjct: 559 IVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDND-- 616
Query: 2229 KQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGAR---AEVTVDLLVNDVNDNPP 2285
F +D +GV+K D E S+Y ++A+D R A+VT++++ DVNDN P
Sbjct: 617 -NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVM--DVNDNSP 673
Query: 2286 IFDQPTYNTTLSEASLIGTP---VLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSS 2342
+ P NT+ L P V +V ++D D+ N + Y IV N+ F ID
Sbjct: 674 VVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG--NNKGLFRIDPV 731
Query: 2343 SGLILTARMLDHELVQHCTLKVRSIDSGFP-SLSSEVLVHIYISDVNDNPPVFNQLI 2398
+G I V L V D G+P SL + VLV +Y++D N LI
Sbjct: 732 TGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLI 788
Score = 155 bits (392), Expect = 9e-37
Identities = 139/491 (28%), Positives = 220/491 (44%), Gaps = 42/491 (8%)
Query: 3114 QSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADS 3173
Q I+ I E++ +N P+ + + N AT G + +VY L
Sbjct: 24 QELIYTIREELPENVPIGNIPKDLNISHINAAT--------------GTSASLVYRLVSK 69
Query: 3174 AGG--VFSIDSSSG-IIILEQPLDREQQ---SSYNISVRATDQSPGQSLSS----LTTVT 3223
AG + + SS+G I +DRE+ +SY + L + L +
Sbjct: 70 AGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIK 129
Query: 3224 ITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGK 3283
I V D NDN P+F +++PE+T ++ AT D G N Y + +G
Sbjct: 130 IIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFG 189
Query: 3284 FKINPKTGG-----ISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNP 3338
I G + V + LD E + + ++ +DGGTP S+ A + + ++DVNDN
Sbjct: 190 LDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNR 249
Query: 3339 PKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSI---VNGDRDNEFTVDPVL 3395
P F + I E+A VG SVI L A D D N +I + V F ++
Sbjct: 250 PVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTT 309
Query: 3396 GLVKVKKKLDRERVSGYSLLVQAVD-SGIPAMSSTATVNIDISDVNDNSP------VFTP 3448
GL+ V++ LDRE + + + V A D S PA ATV I+++DVNDN P + +P
Sbjct: 310 GLITVQRSLDREETAIHKVTVLASDGSSTPAR---ATVTINVTDVNDNPPNIDLRYIISP 366
Query: 3449 ANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPHGILRSAVV 3508
N T + E PV T I + V+D+D+ NG F + V D +L ++ +
Sbjct: 367 INGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSL 426
Query: 3509 FQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGG 3568
+ + E+ + A DSGKP +RV++ +E+ + P I + E++ G
Sbjct: 427 LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGL 486
Query: 3569 VIGKIHATDQD 3579
+ I ATD+D
Sbjct: 487 YLTTISATDED 497
Score = 143 bits (361), Expect = 3e-33
Identities = 162/691 (23%), Positives = 286/691 (41%), Gaps = 78/691 (11%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD 202
K+ I V D ND P+F +++I E+T + + +ATD D G NG +Y N
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 203 LFS---VHPTSG----VISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVH 255
+F V G + + L+ ++K+ Y ++I D G SSTA L V
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDG-----GTPQKSSTAILQVT 241
Query: 256 IERINEHAPTI---HVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQF 312
+ +N++ P V H+P + + + D D G+N EI + P +
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
Query: 313 FLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTV 372
A I ++ +D E L + +P + + V N +
Sbjct: 302 LFALNN---TTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNI 358
Query: 373 PIRFEKEVYD--VSISEFSPPGVVVAIVKLSPEPIDVEYKL---SPGEDAVYFK-INPRS 426
+R+ + V +SE P +A++ +S + DV K+ E + K +
Sbjct: 359 DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ 418
Query: 427 GLIVTARPLNTVKKEVYKLEVTNKEG-----DLKAQVTISIEDANDHTPEFQQPLYDAYV 481
L+ T+ L+ + + ++ + + A V + +ED ND+ P F QP+ + V
Sbjct: 419 YLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSV 478
Query: 482 NESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPE 541
+E+ G + T+SA+D+D G+N I Y + N F +++ TGV++ + D E E
Sbjct: 479 SENNRRGLYLTTISATDEDSGKNADIVYQLGP-NASFFDLDRKTGVLTASRVFDREEQ-E 536
Query: 542 IYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVS 601
+ F V A D G+P +S+ V + + + NDNSP F Q +S + P + ++
Sbjct: 537 RFIFTVTARDNGTP-PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT 595
Query: 602 AIDID--ELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE 659
D D E + V I++ N+ F L+P SGV +K +++ + ++ + ATDG
Sbjct: 596 VTDADAGENKAVTLSILNDND--NFVLDPYSGV--IKSNVSFDREQQSSYTFDVKATDGG 651
Query: 660 NLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSIN 719
+ +++ V+ S ++I +N L
Sbjct: 652 QPPRSSTAKVTINVMDVNDNS--------------PVVISPPSNTSFKL----------- 686
Query: 720 RQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME 779
V G+ + ++ A D D+G N ++ +TI GN F ID
Sbjct: 687 ---------------VPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPV 731
Query: 780 TGQLKVLMPMDREHTDLYLLNITIYDLGNPQ 810
TG + + L+ L + I DLG P+
Sbjct: 732 TGNITLEEKPAPTDVGLHRLVVNISDLGYPK 762
Score = 78.6 bits (192), Expect = 1e-13
Identities = 70/271 (25%), Positives = 122/271 (45%), Gaps = 26/271 (9%)
Query: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEV--IIADFCFLR 106
N ++ V+ +R G+ L +S + DE+ A+ V + + F
Sbjct: 465 NPPIFNQPVIELSVSENNRRGLYLTTIS--------ATDEDSGKNADIVYQLGPNASFFD 516
Query: 107 IRTKGG---NSAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFSPTT 162
+ K G S + +RE Q+ ++ V G L++ V + VLD ND P F+
Sbjct: 517 LDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNH 576
Query: 163 YSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYD 222
+ ++E+ P ++V +T TDAD G N N D F + P SGVI + + +
Sbjct: 577 FQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDRE 636
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTI------HVVTHVPFSL 276
+++ Y ++ A D G SSTAK+ +++ +N+++P + VP S
Sbjct: 637 QQSSYTFDVKATDGGQP-----PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 277 EKEPTYAVVTVDDLDDGANGEIESVSIVAGD 307
A V D+D G N E++ +IV+G+
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELK-YTIVSGN 721
Score = 53.9 bits (128), Expect = 4e-06
Identities = 53/211 (25%), Positives = 92/211 (43%), Gaps = 20/211 (9%)
Query: 3432 VNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNE 3491
+ I + D NDN+P+F I EN + + TD D+ NG + +L+G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQH-YELLNG-- 184
Query: 3492 EEEFVLD----PHGILRSAVVFQHTESLE----YVLCVQAKDSGKPQQVSHTYIRVRVIE 3543
+ F LD P G ++ Q E YV+ ++ +D G PQ+ S ++V V +
Sbjct: 185 QSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSD 244
Query: 3544 ESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYD------VLTFALKSEQKSLFK 3597
+ ++P ++ + E+ G + ++HATD D+ + + K LF
Sbjct: 245 VNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 3598 VNSHDGKIIALGGLD---SGKYVLNVSVSDG 3625
+N+ G I LD + + + V SDG
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDG 335
>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
Length = 1237
Score = 276 bits (706), Expect = 3e-73
Identities = 223/745 (29%), Positives = 343/745 (46%), Gaps = 67/745 (8%)
Query: 703 NGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVL 762
NG L +G ++ IN P F + +A+ E+ +G+ A D D+G NG
Sbjct: 146 NGSPRLLEGQIEVQDINDNTPNFASPVIT-LAIPENTNIGSLFPIPLASDRDAGPNGVAS 204
Query: 763 FTISDG-NTDSCFNIDM------ETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWR 815
+ + G F + + + QL V+ +DRE D Y L I + D G+P ++S
Sbjct: 205 YELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264
Query: 816 LLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ 875
LL + V D NDN+P F + SY + E+S IG +IQV+A D D G+N E+ Y+ +
Sbjct: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324
Query: 876 ----QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVND 931
++ +TG++ V +DRE + + A+D+ + + + V + V D+ND
Sbjct: 325 VVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTV--KDMND 382
Query: 932 CSPAF--------IPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRF 983
+P + ED+ T +A ++ D D G V + D F
Sbjct: 383 NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDV--PF 440
Query: 984 EIDKASGA---------IRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDV 1034
++ +AS ++ + LDYEK + Y + + A D G P LSS + ++V+VVDV
Sbjct: 441 QLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNP-PLSSTNSLKVQVVDV 499
Query: 1035 NENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIR-DGSGLGRFSI 1093
N+N P F + EN++ G + ++TA D DSG + E+ YS+ + + G F+I
Sbjct: 500 NDN--APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTI 557
Query: 1094 DDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
E+G I LDRE SY L V A DRG L T V + V D NDN P Y
Sbjct: 558 SPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGY 617
Query: 1154 YPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLD 1213
VMEN P V + D D N ++ + N F I TG I +S D
Sbjct: 618 NFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD--FVIQNGTGTI-LSSLSFD 674
Query: 1214 REQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGE 1273
REQQ+ + ++ DGG P+ + + V + VLDENDN P + + GE
Sbjct: 675 REQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGE 734
Query: 1274 PIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDI--LTIKA 1331
+ + A D D G NAE+ YSI GN G F I +G ++ K+ + + L +K
Sbjct: 735 TVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794
Query: 1332 VDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANT 1391
D G+P + TA +H L +E N T++E+ ++G +T
Sbjct: 795 SDRGKPPRYGTALVH-------------LYVNETLANRTLLET-----LLG----HSLDT 832
Query: 1392 PLWFDIVGGNFDSAFDAEKGVGTIV 1416
PL DI G D ++ K G I+
Sbjct: 833 PLDIDIAG---DPEYERSKQRGNIL 854
Score = 244 bits (624), Expect = 1e-63
Identities = 195/666 (29%), Positives = 306/666 (45%), Gaps = 41/666 (6%)
Query: 2912 VRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRG 2971
+ V DINDN P FA V + E+ G + + DRD N SY + G P
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGP-NGVASYELQAG-PEA 213
Query: 2972 RFALGLVQSEWK------VYVKRPLDREEQDIYFLNITATDGLF---VTQAMVEVSVSDV 3022
+ GL +E + + V LDRE D Y L I DG + A++ V+V D
Sbjct: 214 QELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273
Query: 3023 NDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSG---NSEFFLD 3079
NDN+P ++ +Y A L E+ P +++V A D+D G+N I Y+ + + LD
Sbjct: 274 NDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLD 333
Query: 3080 PESGELKTLALLDRERIPV--YSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYN 3137
+G + +DRE + +S++AK + ++ + + ++D+NDN P
Sbjct: 334 RNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIG 393
Query: 3138 TCVY--------ENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG---- 3185
+ E+ A + + VQ D D G N V +A S +G
Sbjct: 394 LVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSK 453
Query: 3186 ---IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYL 3242
+ PLD E+ Y I + A D S LSS ++ + V+D+NDN PVF +
Sbjct: 454 KKYFLQTTTPLDYEKVKDYTIEIVAVD-SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTE 512
Query: 3243 VTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIR-SGNEQGKFKINPKTGGISVSEVLDY 3301
V PE+ PG + + A+ D G+NAE+ Y + +G F I+P+TG I V LD
Sbjct: 513 VAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDR 572
Query: 3302 ELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
E + + L V A D G+P+L ATV +N+ D NDN PKF Y+ + E+ V
Sbjct: 573 EQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVG 632
Query: 3362 LLIAEDVDSQPNGQIHFSIVNGDRDN-EFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVD 3420
++ D D N Q+ S+ ++DN +F + G + DRE+ S Y+ ++AVD
Sbjct: 633 MVTVIDGDKGENAQVQLSV---EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVD 689
Query: 3421 SGIPAMSSTATVNIDISDVNDNSPVFTPANYTA--VIQENKPVGTSILQLVVTDRDSFHN 3478
G+P S+ V I++ D NDN+P T + T+ ++ +G ++ Q+ D DS N
Sbjct: 690 GGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVN 749
Query: 3479 GPPFSFSILSGNEEEEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYI 3537
+SI GN F + H G + + + L V+ D GKP + +
Sbjct: 750 A-ELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALV 808
Query: 3538 RVRVIE 3543
+ V E
Sbjct: 809 HLYVNE 814
Score = 241 bits (615), Expect = 1e-62
Identities = 206/648 (31%), Positives = 290/648 (44%), Gaps = 66/648 (10%)
Query: 2802 IKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEK 2861
+ VLD NDN P FE SY+ + E P+G + QV+A D D GAN ++ Y+ H PE
Sbjct: 268 VTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFH--QAPEV 325
Query: 2862 VMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNA 2921
V +D NTG I+ +D E T FSV+A D G S+ A V V V D+NDNA
Sbjct: 326 VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNA 384
Query: 2922 P--------VFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRF 2973
P + + N+ E VA++ DRD + N V+ + G P
Sbjct: 385 PTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGE-NAAVTCVVAGDVPFQLR 443
Query: 2974 ALGLVQSEWK----VYVKRPLDREEQDIYFLNITATDG----LFVTQAMVEVSVSDVNDN 3025
S+ K + PLD E+ Y + I A D L T ++ +V V DVNDN
Sbjct: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSL-KVQVVDVNDN 502
Query: 3026 SPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL--YGSGNSEFFLDPESG 3083
+PV Q PE+ ++I +++A DAD GSN + YSL + F + PE+G
Sbjct: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562
Query: 3084 ELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVY 3141
E++ LDRE+ Y L A D G Q +++ D NDN P F YN V
Sbjct: 563 EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVM 622
Query: 3142 ENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSY 3201
EN + + V +D D G N +V S+ + G F I + +G I+ DREQQS+Y
Sbjct: 623 ENMPALSPVGMVTVIDGDKGENAQVQLSV-EQDNGDFVIQNGTGTILSSLSFDREQQSTY 681
Query: 3202 NISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSP---------G 3252
++A D S+ VTI VLD NDN P +T P +TS G
Sbjct: 682 TFQLKAVDGGV-PPRSAYVGVTINVLDENDNAP-------YITAPSNTSHKLLTPQTRLG 733
Query: 3253 TQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVE 3312
V V A D G NAE+ Y I GN G F+I +G I++ + ++ LVV+
Sbjct: 734 ETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVK 793
Query: 3313 AKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQP 3372
D G P A V++ + + N + L+G S+ + D+ P
Sbjct: 794 VSDRGKPPRYGTALVHLYVNETLANRTLL-----------ETLLGHSLDTPLDIDIAGDP 842
Query: 3373 -------NGQIHFSIVNGDRDNEFTVDPVLGL-VKVKKKLDRERVSGY 3412
G I F +V G V ++ L V V+ RE SGY
Sbjct: 843 EYERSKQRGNILFGVVAG----VVAVALLIALAVLVRYCRQREAKSGY 886
Score = 239 bits (609), Expect = 6e-62
Identities = 188/670 (28%), Positives = 304/670 (45%), Gaps = 44/670 (6%)
Query: 3016 EVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLY-GSGNS 3074
++ V D+NDN+P T +PE+ + A D D G NG Y L G
Sbjct: 155 QIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 3075 EFF-------LDPESGELKTLALLDRERIPVYSLMAKATDGGG--RFCQSNIHLILEDVN 3125
E F + + +L + LDRER Y L K DGG R + + + + D N
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274
Query: 3126 DNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGV---FSIDS 3182
DN P F Y + EN+ + +V+A D D G N ++ Y+ + V +D
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDR 334
Query: 3183 SSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERR--- 3239
++G+I ++ P+DRE S+ SV A D+ S+ V +TV D+NDN P E R
Sbjct: 335 NTGLITVQGPVDREDLSTLRFSVLAKDRGTNPK-SARAQVVVTVKDMNDNAPTIEIRGIG 393
Query: 3240 -----DYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGG-- 3292
D + + ED + T V V + +D G NA +T ++ +G+ + + +TG
Sbjct: 394 LVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVV-AGDVPFQLRQASETGSDS 452
Query: 3293 -----ISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYS 3347
+ + LDYE K + + + A D G P LS+ ++ + + DVNDN P F+Q V
Sbjct: 453 KKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTE 512
Query: 3348 AVISEDALVGDSVILLIAEDVDSQPNGQIHFSIV-NGDRDNEFTVDPVLGLVKVKKKLDR 3406
E+ G+ + + A D DS N ++ +S+ FT+ P G ++VK LDR
Sbjct: 513 VAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDR 572
Query: 3407 ERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSIL 3466
E+ Y L V A D G P++ TATV +++ D NDN P F + Y + EN P + +
Sbjct: 573 EQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVG 632
Query: 3467 QLVVTDRDSFHNGPPFSFSILSGNEEEEFVL-DPHGILRSAVVFQHTESLEYVLCVQAKD 3525
+ V D D N + + +FV+ + G + S++ F + Y ++A D
Sbjct: 633 MVTVIDGDKGENA---QVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVD 689
Query: 3526 SGKPQQVSHTYIRVRVIEESTHKP--TAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--- 3580
G P + ++ + + V++E+ + P TA + G + ++ A D D
Sbjct: 690 GGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVN 749
Query: 3581 YDVLTFALKSEQKSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDGRFQVPIDVVVHV 3637
+++ LF++ SH G I ++ G + L V VSD R + P V
Sbjct: 750 AELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD-RGKPPRYGTALV 808
Query: 3638 EQLVHEMLQN 3647
V+E L N
Sbjct: 809 HLYVNETLAN 818
Score = 231 bits (589), Expect = 1e-59
Identities = 194/675 (28%), Positives = 298/675 (44%), Gaps = 58/675 (8%)
Query: 1028 EVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSG 1087
++EV D+N+N TP F + ++ EN+ IG+ A D D+G +G Y ++ G
Sbjct: 155 QIEVQDINDN--TPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212
Query: 1088 LGRF-------SIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVED 1140
+++ + LDRE SY LT+ D G P S+ + + V D
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD 272
Query: 1141 VNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNP--QNFFAI 1198
NDNAP P Y + ENSP SVIQ++A D D +N ++ Y + +
Sbjct: 273 TNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332
Query: 1199 NIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKV 1258
+ TGLIT +DRE + V D G +PK + VVV V D NDN P +
Sbjct: 333 DRNTGLITVQG-PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRG 391
Query: 1259 YQIKLPERDRKKRGEPIYRAFAF------DRDEGPNAEISYSIVDGNDDGKFFIDPKTGM 1312
+ + E + A DRDEG NA ++ +V G+ + +TG
Sbjct: 392 IGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT-CVVAGDVPFQLRQASETGS 450
Query: 1313 VSSRKQF----TAGSYD-----ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFD 1363
S +K F T Y+ + I AVD+G P SST L ++ + +P+ F
Sbjct: 451 DSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV---FT 507
Query: 1364 EPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAE-----KGV------ 1412
+ E+++ E++ ++ A++ G N + + E KG+
Sbjct: 508 QSVTEVAFPENNKPGEVIAEITASDADS-------GSNAELVYSLEPEPAAKGLFTISPE 560
Query: 1413 -GTIVIAKPLDAEQRSIYNMSVEVTDGTNVAV---TQVFIKVLDNNDNGPEFSQPNYDVT 1468
G I + LD EQR Y + V D + ++ V + VLD NDN P+F Y+ +
Sbjct: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620
Query: 1469 ISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEA 1528
+ E++ + + + D D+ + D+ F I TG + ++ D E
Sbjct: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN---GDFVIQNGTGTILSSLSFDREQ 677
Query: 1529 QDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEAS--VFESAALGSAVL 1586
Q + + D P R V +NV D ND++PY T P + + LG V
Sbjct: 678 QSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVS 737
Query: 1587 QVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQ 1646
QV A D D G NAELIY+I GN +F+I G IT+ KE + G L +KV+D+
Sbjct: 738 QVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDR 797
Query: 1647 GSPPMSATAIVRISV 1661
G PP TA+V + V
Sbjct: 798 GKPPRYGTALVHLYV 812
Score = 208 bits (529), Expect = 1e-52
Identities = 213/796 (26%), Positives = 340/796 (42%), Gaps = 107/796 (13%)
Query: 1185 YRITSGNPQNFFAINIKTGLITTTSRKLDRE--QQAEHFL---------EVTVTDGGPSP 1233
Y++ G P + ++ KTG I TT +DRE ++ ++ L EV++TD +
Sbjct: 90 YKLEVGAP--YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNG 147
Query: 1234 KQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISY 1293
+ ++V D NDN P F V + +PE PI A DRD GPN SY
Sbjct: 148 SPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPI--PLASDRDAGPNGVASY 205
Query: 1294 SIVDGNDDGKFF----------IDPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTA 1343
+ G + + F P+ ++ + + SYD LTIK D G P ++S+A
Sbjct: 206 ELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYD-LTIKVQDGGSPPRASSA 264
Query: 1344 RLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVV----SVQPANTPLWFDIVG 1399
L + + +P F+ P Y + E+ + V V S Q AN + +
Sbjct: 265 LLRVTVLDTNDNAP---KFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEY---- 317
Query: 1400 GNFDSAFDA-------EKGVGTIVIAKPLDAEQRSIYNMSVEVTD-GTNV--AVTQVFIK 1449
F A + ++ G I + P+D E S SV D GTN A QV +
Sbjct: 318 -TFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVT 376
Query: 1450 VLDNNDNGPEF--------SQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTV---- 1497
V D NDN P + + ISEDV +T + ++ +DRDE + T
Sbjct: 377 VKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAG 436
Query: 1498 --------HSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNL 1549
S S S +K+ L T LD+E + + I+ D P +
Sbjct: 437 DVPFQLRQASETGSDSKKKY-------FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSST 489
Query: 1550 ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGN 1609
+ V V D ND++P FT + E + E+ G + ++TA D D G NAEL+Y++E
Sbjct: 490 NSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEP 549
Query: 1610 TGN-MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSH 1668
+F I P G I + D + L + D+GSP + TA V ++V +++
Sbjct: 550 AAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDND 609
Query: 1669 PKFIHKDYQAEVNENVDIGTSVILISAI-------SQSTLIYEVKDGDINGIFTINPYSG 1721
PKF+ Y V EN+ + V +++ I +Q L E +GD F I +G
Sbjct: 610 PKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD----FVIQNGTG 665
Query: 1722 VITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDENDNAPVFLFSQYSGSLS 1779
I + + D E+ S+Y ++A + + ++ V I ++DENDNAP ++ + + S
Sbjct: 666 TILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHK 724
Query: 1780 EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANL 1839
P + ++ + A D DS NA L+Y I F + S +GAI +
Sbjct: 725 LLTPQTRLGETVSQ----VAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI 780
Query: 1840 DHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETIL--LLPTY 1897
+ V V D G P + V + + T N + + ET+L L T
Sbjct: 781 ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLAN-------RTLLETLLGHSLDTP 833
Query: 1898 VGVEVLKVSATDPDSE 1913
+ +++ A DP+ E
Sbjct: 834 LDIDI----AGDPEYE 845
Score = 196 bits (499), Expect = 3e-49
Identities = 192/723 (26%), Positives = 299/723 (41%), Gaps = 76/723 (10%)
Query: 2336 YFHIDSSSGLILTARM-LDHELVQHCTLKVRS--------------IDSGFPSLSSEVLV 2380
Y +D +G I T +D E ++ C ++ + +G P L
Sbjct: 98 YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG--- 154
Query: 2381 HIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRT 2440
I + D+NDN P F + + E G ASD D+ Y + +G +
Sbjct: 155 QIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 2441 SFL--------MDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLF---TSTAQVHIRVLGA 2489
+ + +I + N ++R + Y L + V DG S+A + + VL
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDS-YDLTIKVQDGGSPPRASSALLRVTVLDT 273
Query: 2490 NLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIIN--DFAKDRFLID 2547
N +P F + +Y AE+ EN G VI V+A D D G +I Y + + +D
Sbjct: 274 NDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLD 333
Query: 2548 SNGQVITTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYR 2606
N +IT + +DRE+ S+ + ++ V V V D NDNAP T+E R
Sbjct: 334 RNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP---TIEIR 390
Query: 2607 -----------ASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDP 2655
A++ DV V VQ D D+G N+ +T + + + E
Sbjct: 391 GIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGS 450
Query: 2656 DNG-----WMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQ 2710
D+ T ++ ++K+ + + AVD G P S + + V+ P FTQ
Sbjct: 451 DSKKKYFLQTTTPLDYEKVKDYTIE--IVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508
Query: 2711 SQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGE-----RPENNKGGIFVIEQETGTI 2765
S E+ G + + + S N E PE G+F I ETG I
Sbjct: 509 SVTEVAFPENNKPGEVIAEITASDAD----SGSNAELVYSLEPEPAAKGLFTISPETGEI 564
Query: 2766 KLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIME 2825
++ LDRE ++ KV A + T V + VLD NDN P F S Y+ +ME
Sbjct: 565 QVKTSLDREQRESYELKVVAA-DRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
Query: 2826 GMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHET 2885
MP + + V ID D G N QV S+ D+ F I + TG I + D E
Sbjct: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD------FVIQNGTGTILSSLSFDREQ 677
Query: 2886 DPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGN--VKESDPPGEVV 2943
T+TF + A D G S+ V++ V D NDNAP + + GE V
Sbjct: 678 QSTYTFQLKAVD-GGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETV 736
Query: 2944 AVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNIT 3003
+ ++ D D S VN ++ Y I GGNP G F +G + +++ ++R ++ L +
Sbjct: 737 SQVAAEDFD-SGVNAELIYSIAGGNPYGLFQIG--SHSGAITLEKEIERRHHGLHRLVVK 793
Query: 3004 ATD 3006
+D
Sbjct: 794 VSD 796
Score = 194 bits (492), Expect = 2e-48
Identities = 176/658 (26%), Positives = 297/658 (45%), Gaps = 85/658 (12%)
Query: 390 PPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTN 449
P GV ++ PE ++ + L ED + ++ L+ + + Y L +
Sbjct: 199 PNGVASYELQAGPEAQEL-FGLQVAEDQ-----EEKQPQLIVMGNLDRERWDSYDLTIKV 252
Query: 450 KEGDL-----KAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGEN 504
++G A + +++ D ND+ P+F++P Y+A ++E+ P+G SV+ V A+D D+G N
Sbjct: 253 QDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGAN 312
Query: 505 GYITYSIASLNLLPFVINQF------TGVISTTEELDFESSPEIYRFIVRASDWG-SPYR 557
I Y + + P V+ + TG+I+ +D E + RF V A D G +P
Sbjct: 313 AEIEY---TFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTL-RFSVLAKDRGTNPKS 368
Query: 558 HESEVNVTIRIGNVNDNSPLFEKVACQGV-----------ISYDFPVGGHITAVSAIDID 606
++V VT++ ++NDN+P E +G+ IS D + V D D
Sbjct: 369 ARAQVVVTVK--DMNDNAPTIE---IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRD 423
Query: 607 ELELVKYKIISGNELGFFYLNPDSGVLQLKK-SLTNSGIKNGNFALRITATDGENLADPM 665
E E + ++ F QL++ S T S K F T D E + D
Sbjct: 424 EGENAAVTCVVAGDVPF----------QLRQASETGSDSKKKYFLQTTTPLDYEKVKDYT 473
Query: 666 SINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYF 725
++V G S + + +V +N P F
Sbjct: 474 IEIVAVDSGNPPLSSTNSLKVQVV---------------------------DVNDNAPVF 506
Query: 726 DKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS-DGNTDSCFNIDMETGQLK 784
+S ++VA E+ G I +I A DADSG N ++++++ + F I ETG+++
Sbjct: 507 TQSV-TEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQ 565
Query: 785 VLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESS 844
V +DRE + Y L + D G+P + +NV D NDN P F+ Y+ +++E+
Sbjct: 566 VKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENM 625
Query: 845 GIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKI 904
+ + V D D G N +V SV D F I + TG + + DRE ++ Y+ ++
Sbjct: 626 PALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQL 685
Query: 905 EARDKAESGQQLFSVVTLKVFLDDVNDCSPAF-IPSSYSVKVL-EDLPVGTVIAWLETHD 962
+A D + + VT+ V D ND +P PS+ S K+L +G ++ + D
Sbjct: 686 KAVDGGVPPRSAYVGVTINVL--DENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAED 743
Query: 963 PDLGLGGQVRYSLV--NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
D G+ ++ YS+ N Y G F+I SGAI L KE++ + L V+ D+G+P
Sbjct: 744 FDSGVNAELIYSIAGGNPY-GLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP 800
Score = 184 bits (466), Expect = 2e-45
Identities = 183/656 (27%), Positives = 291/656 (44%), Gaps = 62/656 (9%)
Query: 1448 IKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHK--LSYTVHSSIDSIS 1505
I+V D NDN P F+ P + I E+ + A+DRD SY + + ++
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 1506 MRKFRI----DPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAND 1561
+ ++ + L LD E D + L I V+D P R + A + V V D ND
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275
Query: 1562 HSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGN--TGNMFKIEPV 1619
++P F P YEA + E++ +G +V+QV A D D+G NAE+ YT + +++
Sbjct: 276 NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRN 335
Query: 1620 LGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISV-TMSDNSHPKFI------ 1672
G+IT+ D + S+ D+G+ P SA A V ++V M+DN+ I
Sbjct: 336 TGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395
Query: 1673 -HKDYQAEVNENVDIGTSVIL-------------ISAISQSTLIYEVKDGDINGIFTINP 1718
H+D A ++E+V T+V L ++ + + ++++ G +
Sbjct: 396 THQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKK 455
Query: 1719 YSGVITTQKALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAPVFLFSQYSG 1776
Y + T LDYE+ Y + I A + ++S ++ +Q+VD NDNAPVF S
Sbjct: 456 Y--FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEV 513
Query: 1777 SLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQI-VESTAKKFFTVDSSTGAIRT 1835
+ E ++ I A+DADS NA LVY + E AK FT+ TG I+
Sbjct: 514 AFPENNKPGEVIAE-------ITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQV 566
Query: 1836 IANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILL-- 1893
+LD E + V D GSP L + V VN V D NDN P F + + ++
Sbjct: 567 KTSLDREQRESYELKVVAADRGSPSLQGTATVLVN--VLDCNDNDPKFMLSGYNFSVMEN 624
Query: 1894 LPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVL--TIKNNNLSKDHY 1951
+P V ++ V D +L+ G F+I + +G + ++ + + Y
Sbjct: 625 MPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD---FVIQNGTGTILSSLSFDREQQSTY 681
Query: 1952 MLIVKVSDGKFYSTSM---VTIMVKEAMDSGLHFTQSFYS-----TSISENNTNITKVAI 2003
+K DG S VTI V + D+ + T + T + +++VA
Sbjct: 682 TFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVA- 740
Query: 2004 VNAVGNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEAS 2057
+ +N L YSI NP F+I S SG I T +R L+ LVV+ S
Sbjct: 741 AEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAI-TLEKEIERRHHGLHRLVVKVS 795
Score = 181 bits (458), Expect = 2e-44
Identities = 162/556 (29%), Positives = 262/556 (47%), Gaps = 46/556 (8%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKV-NIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
L+RE D+Y L +K G A + + + VLD ND P F +Y ++E++P+
Sbjct: 238 LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 297
Query: 176 SVAQVTATDADIGSNGEFYYYFKNKVD----LFSVHPTSGVISLSGRLNYDEKNRYDLEI 231
SV QV A D+D G+N E Y F + L + +G+I++ G ++ ++ + +
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSV 357
Query: 232 LAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHV-----VTH------VPFSLEKEP 280
LA DR G N S+ A++ V ++ +N++APTI + VTH + + +E
Sbjct: 358 LAKDR-----GTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEET 412
Query: 281 TYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKE--GKWLNEYKIKERKQIDWESFP 338
A+V V D D+G N + +VAGD Q A E +Y ++ +D+E
Sbjct: 413 AVALVQVSDRDEGENAAV--TCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVK 470
Query: 339 YGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIV 398
Y + + A D G+P S D P+ F + V +V+ E + PG V+A +
Sbjct: 471 -DYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV-FTQSVTEVAFPENNKPGEVIAEI 528
Query: 399 KLSP----EPIDVEYKLSPGEDAV-YFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGD 453
S ++ Y L P A F I+P +G I L+ ++E Y+L+V +
Sbjct: 529 TASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRG 588
Query: 454 L-----KAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYIT 508
A V +++ D ND+ P+F Y+ V E++P + V V+ D DKGEN +
Sbjct: 589 SPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQ 648
Query: 509 YSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRI 568
S+ N FVI TG I ++ D E Y F ++A D G P R + V VTI +
Sbjct: 649 LSVEQDN-GDFVIQNGTGTILSSLSFDREQQ-STYTFQLKAVDGGVPPR-SAYVGVTINV 705
Query: 569 GNVNDNSPLFEKVA--CQGVISYDFPVGGHITAVSAIDID---ELELVKYKIISGNELGF 623
+ NDN+P + +++ +G ++ V+A D D EL+ Y I GN G
Sbjct: 706 LDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELI-YSIAGGNPYGL 764
Query: 624 FYLNPDSGVLQLKKSL 639
F + SG + L+K +
Sbjct: 765 FQIGSHSGAITLEKEI 780
Score = 179 bits (454), Expect = 6e-44
Identities = 196/711 (27%), Positives = 305/711 (42%), Gaps = 72/711 (10%)
Query: 1823 FFTVDSSTGAIRTI-ANLDHETIAH-----------FHFHVHVRD---SGSPQLTAESPV 1867
+ VD TG I T ++D E + F V + D +GSP+L +
Sbjct: 98 YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRL-----L 152
Query: 1868 EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL 1927
E IEV D+NDN P F V + T +G A+D D+ +Y L G
Sbjct: 153 EGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212
Query: 1928 DHFLI---------DSNSGVLTIKNNNLSK-DHYMLIVKVSDGKF---YSTSMVTIMVKE 1974
L + ++ + N + + D Y L +KV DG S++++ + V +
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD 272
Query: 1975 AMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNR--LNEPLKYSILNPGNK----FKI 2028
D+ F + Y +SEN+ V V A + N ++Y+ ++
Sbjct: 273 TNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332
Query: 2029 KSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVF---- 2084
+G+I G P DRE+ V A + + AR V V ++D+NDN+P
Sbjct: 333 DRNTGLITVQG-PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRG 391
Query: 2085 VGLPYY----AAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNS--GN 2138
+GL + A + D T + V D+D+G N VT V+ D F++ S G+
Sbjct: 392 IGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDV-PFQLRQASETGS 450
Query: 2139 VILKEAFNSDLSNI------EYGVTILAKDGGKPSLST--SVELPITIVNKAMPVFDKPF 2190
K+ F + + +Y + I+A D G P LS+ S+++ + VN PVF +
Sbjct: 451 DSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSV 510
Query: 2191 YTASVNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQ----FNIDFDTGVLKVVSPL 2246
+ E+ + I I A+ + ++ +P F I +TG ++V + L
Sbjct: 511 TEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL 570
Query: 2247 DYEVTSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTP 2305
D E +Y+L + A+D + TV + V D NDN P F YN ++ E +P
Sbjct: 571 DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSP 630
Query: 2306 VLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVR 2365
V V ID D N V + QD + F I + +G IL++ D E T +++
Sbjct: 631 VGMVTVIDGDKGENAQVQLSVEQDNGD----FVIQNGTGTILSSLSFDREQQSTYTFQLK 686
Query: 2366 SIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPR---GHFVTCVQASDAD 2422
++D G P S+ V V I + D NDN P S+ L P+ G V+ V A D D
Sbjct: 687 AVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSH-KLLTPQTRLGETVSQVAAEDFD 745
Query: 2423 SSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD 2473
S L YSI GN F + S SG ITL ++R L+ L V VSD
Sbjct: 746 SGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD 796
Score = 166 bits (419), Expect = 6e-40
Identities = 167/658 (25%), Positives = 278/658 (42%), Gaps = 49/658 (7%)
Query: 2153 EYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNT----PILSI 2208
E +T L ++G L +E + +N P F P T ++ E+ + + P+ S
Sbjct: 137 EVSITDLVQNGSPRLLEGQIE--VQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASD 194
Query: 2209 NATSPEGQGIIYIIIDGDPFKQFNIDFDTGV------LKVVSPLDYEVTSAYKLTIRASD 2262
P G + + + F + L V+ LD E +Y LTI+ D
Sbjct: 195 RDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQD 254
Query: 2263 ALTGARAE-VTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKM 2321
+ RA + + V D NDN P F++P+Y LSE S IG V+QV + D+D N
Sbjct: 255 GGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAE 314
Query: 2322 VHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVH 2381
+ Y Q +D ++GLI +D E + V + D G S+ V
Sbjct: 315 IEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVV 374
Query: 2382 IYISDVNDNPPVFN----QLIYE----SYVSELAPRGHFVTCVQASDADSSDFDRLEYSI 2433
+ + D+NDN P L+ + +SE V VQ SD D + + +
Sbjct: 375 VTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGE-NAAVTCV 433
Query: 2434 LSGNDRTSFLMDSKSGVITLSNHRKQRMEPL-------YSLNVSVSDG---LFTSTAQVH 2483
++G+ S++G + + Q PL Y++ + D +ST +
Sbjct: 434 VAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLK 493
Query: 2484 IRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIIND-FAKD 2542
++V+ N +P F+QS EN G + + A+D D G+ ++ Y++ + AK
Sbjct: 494 VQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKG 553
Query: 2543 RFLID-SNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFM 2601
F I G++ LDRE ++ + TV V V+D NDN P+FM
Sbjct: 554 LFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM 613
Query: 2602 TVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMV 2661
Y SV ++ V V ID D G N+++ S+ + V I G ++
Sbjct: 614 LSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-----IQNGTGTIL 668
Query: 2662 TKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSF--TIAE 2719
+ +F++ + + +F +KAVDGG+P + + + V I+VL P T + +
Sbjct: 669 SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTP 728
Query: 2720 DTAIGSTVDTLRILPSQNVWFSTVNGER----PENNKGGIFVIEQETGTIKLDKRLDR 2773
T +G TV + + + S VN E N G+F I +G I L+K ++R
Sbjct: 729 QTRLGETVSQV----AAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIER 782
Score = 164 bits (414), Expect = 2e-39
Identities = 185/698 (26%), Positives = 302/698 (43%), Gaps = 77/698 (11%)
Query: 1757 IQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV 1816
I++ D NDN P F S ++ A P N+ + SL PL A+D D+ N + Y++
Sbjct: 156 IEVQDINDNTPNFA----SPVITLAIPENTNIGSLFPIPL---ASDRDAGPNGVASYELQ 208
Query: 1817 EST-AKKFFTV------DSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEV 1869
A++ F + + + + NLD E + + V+D GSP + + + V
Sbjct: 209 AGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRV 268
Query: 1870 NIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS--L 1927
V D NDN P F + +E L + +G V++V A D D E+ Y+ + +
Sbjct: 269 T--VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVV 326
Query: 1928 DHFL-IDSNSGVLTIKN----NNLSKDHYMLIVKVSDGKFYST-SMVTIMVKEAMDS--- 1978
L +D N+G++T++ +LS + ++ K S + V + VK+ D+
Sbjct: 327 RRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPT 386
Query: 1979 ------GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGN-KFKIKST 2031
GL T +ISE+ T VA+V E + + G+ F+++
Sbjct: 387 IEIRGIGL-VTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445
Query: 2032 SGV---------IQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSP 2082
S +QTT P D E+ + Y + + A + + ++V + D+NDN+P
Sbjct: 446 SETGSDSKKKYFLQTT-TPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAP 504
Query: 2083 VFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDD---YGHFEINPNSGNV 2139
VF A + +PG +I ++TA D D G N E+ Y L+ + G F I+P +G +
Sbjct: 505 VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEI 564
Query: 2140 ILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDI 2199
+K + + + Y + ++A D G PSL + + + +++ D F + N +
Sbjct: 565 QVKTSLDREQRE-SYELKVVAADRGSPSLQGTATVLVNVLD--CNDNDPKFMLSGYNFSV 621
Query: 2200 RMNTPILSINATSPEGQGIIYIIIDGDP---------FKQFNIDF----DTGVLKVVSPL 2246
N P LS P G + +IDGD +Q N DF TG +
Sbjct: 622 MENMPALS-----PVG---MVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSF 673
Query: 2247 DYEVTSAYKLTIRASDALTGAR-AEVTVDLLVNDVNDNPPIFDQP--TYNTTLSEASLIG 2303
D E S Y ++A D R A V V + V D NDN P P T + L+ + +G
Sbjct: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLG 733
Query: 2304 TPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLK 2363
V QV + D DS N + Y I N F I S SG I + ++ L
Sbjct: 734 ETVSQVAAEDFDSGVNAELIYSIAGG--NPYGLFQIGSHSGAITLEKEIERRHHGLHRLV 791
Query: 2364 VRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYES 2401
V+ D G P LVH+Y+++ N + L+ S
Sbjct: 792 VKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHS 829
Score = 145 bits (365), Expect = 1e-33
Identities = 145/576 (25%), Positives = 242/576 (42%), Gaps = 36/576 (6%)
Query: 2043 DREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTL 2102
DRE + Y+L ++ R + ++RV + D NDN+P F Y A + ++ G
Sbjct: 239 DRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHS 298
Query: 2103 IYQVTAIDKDKGPNGEVTYVLQDD----YGHFEINPNSGNVILKEAFN-SDLSNIEYGVT 2157
+ QV A D D+G N E+ Y ++ N+G + ++ + DLS + + +
Sbjct: 299 VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRF--S 356
Query: 2158 ILAKDGGKPSLSTSVELPITI--VNKAMPVFD--------KPFYTASVNEDIRMNTPILS 2207
+LAKD G S ++ +T+ +N P + A+++ED+ T +
Sbjct: 357 VLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVAL 416
Query: 2208 INATS-PEGQ-GIIYIIIDGDPFKQFNIDFDTG-------VLKVVSPLDYEVTSAYKLTI 2258
+ + EG+ + ++ GD Q +TG L+ +PLDYE Y + I
Sbjct: 417 VQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEI 476
Query: 2259 RASDALTGARAEV-TVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSE 2317
A D+ + ++ + V DVNDN P+F Q E + G + ++ + DADS
Sbjct: 477 VAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSG 536
Query: 2318 NNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSE 2377
+N + Y + + + F I +G I LD E + LKV + D G PSL
Sbjct: 537 SNAELVYSLEPEP-AAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGT 595
Query: 2378 VLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGN 2437
V + + D NDN P F Y V E P V V D D + +++ S+
Sbjct: 596 ATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV--EQ 653
Query: 2438 DRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLF---TSTAQVHIRVLGANLYSP 2494
D F++ + +G I S + + Y+ + DG ++ V I VL N +P
Sbjct: 654 DNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP 713
Query: 2495 AFSQSTYVAE--VRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQV 2552
+ + + + G V V A D D G ++ Y+I F I S+
Sbjct: 714 YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGA 773
Query: 2553 ITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRV 2588
IT E+ + E G + V+ D G + T V
Sbjct: 774 ITLEK-EIERRHHGLHRLVVKVSDRGKPPRYGTALV 808
Score = 122 bits (306), Expect = 8e-27
Identities = 166/725 (22%), Positives = 286/725 (39%), Gaps = 105/725 (14%)
Query: 146 IQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK---NKVD 202
I+V D+ND P F+ ++ I E+T + + A+D D G NG Y + +
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 203 LFSVHPTSG------VISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHI 256
LF + + + G L+ + + YDL I D G+ +S+A L V +
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDG-----GSPPRASSALLRVTV 270
Query: 257 ERINEHAPTIHVVTHVPFSLEKEPT-YAVVTV--DDLDDGANGEIESVSIVAGDPLDQFF 313
N++AP ++ E P ++V+ V +D D GAN EIE A + + +
Sbjct: 271 LDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLL 330
Query: 314 LAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVP 373
L I + +D E ++ AKD+G+ K + + V D P
Sbjct: 331 RLDRNTGL----ITVQGPVDREDLS-TLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP 385
Query: 374 IRFEKEVYDV-------SISEFSPPGVVVAIVKLSPEPI------------DVEYKLSPG 414
+ + V +ISE VA+V++S DV ++L
Sbjct: 386 TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT-----NKEGDLKAQVTISIEDANDHT 469
+ + + + T PL+ K + Y +E+ N + + + D ND+
Sbjct: 446 SET--GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI----ASLNLLPFVINQFT 525
P F Q + + E+ G + ++ASD D G N + YS+ A+ L F I+ T
Sbjct: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL--FTISPET 561
Query: 526 GVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQG 585
G I LD E E Y V A+D GSP + V + + + NDN P F
Sbjct: 562 GEIQVKTSLDREQR-ESYELKVVAADRGSP-SLQGTATVLVNVLDCNDNDPKFMLSGYNF 619
Query: 586 VISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIK 645
+ + P + V+ ID D+ E + ++ + G F + +G + SL+ +
Sbjct: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGT--ILSSLSFDREQ 677
Query: 646 NGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGK 705
+ ++ A DG P S + V
Sbjct: 678 QSTYTFQLKAVDGG--VPPRSAYVGV---------------------------------T 702
Query: 706 LNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLP---VGANILKIKAYDADSGFNGKVL 762
+N+ D N PY + PS+ + K P +G + ++ A D DSG N +++
Sbjct: 703 INVLDE-------NDNAPYI--TAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELI 753
Query: 763 FTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVE 822
++I+ GN F I +G + + ++R H L+ L + + D G P + L+ + V
Sbjct: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVN 813
Query: 823 DANDN 827
+ N
Sbjct: 814 ETLAN 818
Score = 82.4 bits (202), Expect = 9e-15
Identities = 94/401 (23%), Positives = 165/401 (41%), Gaps = 57/401 (14%)
Query: 120 EIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQ 179
+++D + IV L + + +QV+D+ND P+F+ + V E+ +A+
Sbjct: 468 KVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAE 527
Query: 180 VTATDADIGSNGEFYYYFKNK---VDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDR 236
+TA+DAD GSN E Y + + LF++ P +G I + L+ +++ Y+L+++A DR
Sbjct: 528 ITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADR 587
Query: 237 GMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANG 296
G+ + TA + V++ N++ P + + +E P + V + + DG G
Sbjct: 588 -----GSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 642
Query: 297 EIESVSI-VAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
E V + V D D G L+ +Q Y L+A D G P +
Sbjct: 643 ENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQST-------YTFQLKAVDGGVPPR 695
Query: 356 CSAL-----------KAVYIGNPTRD-----TVPIRFEKEVYDVSISEFSPPGVVVAIVK 399
+ + A YI P+ T R + V V+ +F GV ++
Sbjct: 696 SAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFD-SGVNAELI- 753
Query: 400 LSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVT 459
Y ++ G F+I SG I T++KE+ + G + V
Sbjct: 754 ---------YSIAGGNPYGLFQIGSHSGAI-------TLEKEIER----RHHGLHRLVVK 793
Query: 460 ISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKD 500
+S P + L YVNE++ T + T+ D
Sbjct: 794 VS---DRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLD 831
Score = 70.9 bits (172), Expect = 3e-11
Identities = 65/256 (25%), Positives = 115/256 (44%), Gaps = 21/256 (8%)
Query: 117 LNREIQDNYLLIVKGSVRGE-DLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
L+RE +++Y L V + RG L+ V + VLD ND P F + Y+ ++ E+ P +
Sbjct: 570 LDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALS 629
Query: 176 SVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V VT D D G N + + F + +G I S + ++++ Y ++ AVD
Sbjct: 630 PVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVD 689
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSL-----EKEPTYAVVTVDDL 290
G+ S+ + +++ N++AP I ++ L T + V +D
Sbjct: 690 GGVP-----PRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDF 744
Query: 291 DDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYG-YNLTLQAKD 349
D G N E+ SI G+P F + + K ER+ +G + L ++ D
Sbjct: 745 DSGVNAEL-IYSIAGGNPYGLFQIGSHSGAITLEKEIERRH-------HGLHRLVVKVSD 796
Query: 350 KGSPQKC-SALKAVYI 364
+G P + +AL +Y+
Sbjct: 797 RGKPPRYGTALVHLYV 812
>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
Length = 1060
Score = 276 bits (706), Expect = 3e-73
Identities = 223/745 (29%), Positives = 343/745 (46%), Gaps = 67/745 (8%)
Query: 703 NGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVL 762
NG L +G ++ IN P F + +A+ E+ +G+ A D D+G NG
Sbjct: 146 NGSPRLLEGQIEVQDINDNTPNFASPVIT-LAIPENTNIGSLFPIPLASDRDAGPNGVAS 204
Query: 763 FTISDG-NTDSCFNIDM------ETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWR 815
+ + G F + + + QL V+ +DRE D Y L I + D G+P ++S
Sbjct: 205 YELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSA 264
Query: 816 LLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ 875
LL + V D NDN+P F + SY + E+S IG +IQV+A D D G+N E+ Y+ +
Sbjct: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324
Query: 876 ----QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVND 931
++ +TG++ V +DRE + + A+D+ + + + V + V D+ND
Sbjct: 325 VVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTV--KDMND 382
Query: 932 CSPAF--------IPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRF 983
+P + ED+ T +A ++ D D G V + D F
Sbjct: 383 NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDV--PF 440
Query: 984 EIDKASGA---------IRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDV 1034
++ +AS ++ + LDYEK + Y + + A D G P LSS + ++V+VVDV
Sbjct: 441 QLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNP-PLSSTNSLKVQVVDV 499
Query: 1035 NENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIR-DGSGLGRFSI 1093
N+N P F + EN++ G + ++TA D DSG + E+ YS+ + + G F+I
Sbjct: 500 NDN--APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTI 557
Query: 1094 DDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
E+G I LDRE SY L V A DRG L T V + V D NDN P Y
Sbjct: 558 SPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGY 617
Query: 1154 YPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLD 1213
VMEN P V + D D N ++ + N F I TG I +S D
Sbjct: 618 NFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD--FVIQNGTGTI-LSSLSFD 674
Query: 1214 REQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGE 1273
REQQ+ + ++ DGG P+ + + V + VLDENDN P + + GE
Sbjct: 675 REQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGE 734
Query: 1274 PIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDI--LTIKA 1331
+ + A D D G NAE+ YSI GN G F I +G ++ K+ + + L +K
Sbjct: 735 TVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794
Query: 1332 VDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANT 1391
D G+P + TA +H L +E N T++E+ ++G +T
Sbjct: 795 SDRGKPPRYGTALVH-------------LYVNETLANRTLLET-----LLG----HSLDT 832
Query: 1392 PLWFDIVGGNFDSAFDAEKGVGTIV 1416
PL DI G D ++ K G I+
Sbjct: 833 PLDIDIAG---DPEYERSKQRGNIL 854
Score = 244 bits (624), Expect = 1e-63
Identities = 195/666 (29%), Positives = 306/666 (45%), Gaps = 41/666 (6%)
Query: 2912 VRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRG 2971
+ V DINDN P FA V + E+ G + + DRD N SY + G P
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGP-NGVASYELQAG-PEA 213
Query: 2972 RFALGLVQSEWK------VYVKRPLDREEQDIYFLNITATDGLF---VTQAMVEVSVSDV 3022
+ GL +E + + V LDRE D Y L I DG + A++ V+V D
Sbjct: 214 QELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273
Query: 3023 NDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSG---NSEFFLD 3079
NDN+P ++ +Y A L E+ P +++V A D+D G+N I Y+ + + LD
Sbjct: 274 NDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLD 333
Query: 3080 PESGELKTLALLDRERIPV--YSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYN 3137
+G + +DRE + +S++AK + ++ + + ++D+NDN P
Sbjct: 334 RNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIG 393
Query: 3138 TCVY--------ENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG---- 3185
+ E+ A + + VQ D D G N V +A S +G
Sbjct: 394 LVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSK 453
Query: 3186 ---IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYL 3242
+ PLD E+ Y I + A D S LSS ++ + V+D+NDN PVF +
Sbjct: 454 KKYFLQTTTPLDYEKVKDYTIEIVAVD-SGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTE 512
Query: 3243 VTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIR-SGNEQGKFKINPKTGGISVSEVLDY 3301
V PE+ PG + + A+ D G+NAE+ Y + +G F I+P+TG I V LD
Sbjct: 513 VAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDR 572
Query: 3302 ELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
E + + L V A D G+P+L ATV +N+ D NDN PKF Y+ + E+ V
Sbjct: 573 EQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVG 632
Query: 3362 LLIAEDVDSQPNGQIHFSIVNGDRDN-EFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVD 3420
++ D D N Q+ S+ ++DN +F + G + DRE+ S Y+ ++AVD
Sbjct: 633 MVTVIDGDKGENAQVQLSV---EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVD 689
Query: 3421 SGIPAMSSTATVNIDISDVNDNSPVFTPANYTA--VIQENKPVGTSILQLVVTDRDSFHN 3478
G+P S+ V I++ D NDN+P T + T+ ++ +G ++ Q+ D DS N
Sbjct: 690 GGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVN 749
Query: 3479 GPPFSFSILSGNEEEEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYI 3537
+SI GN F + H G + + + L V+ D GKP + +
Sbjct: 750 A-ELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALV 808
Query: 3538 RVRVIE 3543
+ V E
Sbjct: 809 HLYVNE 814
Score = 241 bits (615), Expect = 1e-62
Identities = 206/648 (31%), Positives = 290/648 (44%), Gaps = 66/648 (10%)
Query: 2802 IKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEK 2861
+ VLD NDN P FE SY+ + E P+G + QV+A D D GAN ++ Y+ H PE
Sbjct: 268 VTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFH--QAPEV 325
Query: 2862 VMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNA 2921
V +D NTG I+ +D E T FSV+A D G S+ A V V V D+NDNA
Sbjct: 326 VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNA 384
Query: 2922 P--------VFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRF 2973
P + + N+ E VA++ DRD + N V+ + G P
Sbjct: 385 PTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGE-NAAVTCVVAGDVPFQLR 443
Query: 2974 ALGLVQSEWK----VYVKRPLDREEQDIYFLNITATDG----LFVTQAMVEVSVSDVNDN 3025
S+ K + PLD E+ Y + I A D L T ++ +V V DVNDN
Sbjct: 444 QASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSL-KVQVVDVNDN 502
Query: 3026 SPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL--YGSGNSEFFLDPESG 3083
+PV Q PE+ ++I +++A DAD GSN + YSL + F + PE+G
Sbjct: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562
Query: 3084 ELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVY 3141
E++ LDRE+ Y L A D G Q +++ D NDN P F YN V
Sbjct: 563 EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVM 622
Query: 3142 ENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSY 3201
EN + + V +D D G N +V S+ + G F I + +G I+ DREQQS+Y
Sbjct: 623 ENMPALSPVGMVTVIDGDKGENAQVQLSV-EQDNGDFVIQNGTGTILSSLSFDREQQSTY 681
Query: 3202 NISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSP---------G 3252
++A D S+ VTI VLD NDN P +T P +TS G
Sbjct: 682 TFQLKAVDGGV-PPRSAYVGVTINVLDENDNAP-------YITAPSNTSHKLLTPQTRLG 733
Query: 3253 TQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVE 3312
V V A D G NAE+ Y I GN G F+I +G I++ + ++ LVV+
Sbjct: 734 ETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVK 793
Query: 3313 AKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQP 3372
D G P A V++ + + N + L+G S+ + D+ P
Sbjct: 794 VSDRGKPPRYGTALVHLYVNETLANRTLL-----------ETLLGHSLDTPLDIDIAGDP 842
Query: 3373 -------NGQIHFSIVNGDRDNEFTVDPVLGL-VKVKKKLDRERVSGY 3412
G I F +V G V ++ L V V+ RE SGY
Sbjct: 843 EYERSKQRGNILFGVVAG----VVAVALLIALAVLVRYCRQREAKSGY 886
Score = 239 bits (609), Expect = 6e-62
Identities = 188/670 (28%), Positives = 304/670 (45%), Gaps = 44/670 (6%)
Query: 3016 EVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLY-GSGNS 3074
++ V D+NDN+P T +PE+ + A D D G NG Y L G
Sbjct: 155 QIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 3075 EFF-------LDPESGELKTLALLDRERIPVYSLMAKATDGGG--RFCQSNIHLILEDVN 3125
E F + + +L + LDRER Y L K DGG R + + + + D N
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274
Query: 3126 DNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGV---FSIDS 3182
DN P F Y + EN+ + +V+A D D G N ++ Y+ + V +D
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDR 334
Query: 3183 SSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERR--- 3239
++G+I ++ P+DRE S+ SV A D+ S+ V +TV D+NDN P E R
Sbjct: 335 NTGLITVQGPVDREDLSTLRFSVLAKDRGTNPK-SARAQVVVTVKDMNDNAPTIEIRGIG 393
Query: 3240 -----DYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGG-- 3292
D + + ED + T V V + +D G NA +T ++ +G+ + + +TG
Sbjct: 394 LVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVV-AGDVPFQLRQASETGSDS 452
Query: 3293 -----ISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYS 3347
+ + LDYE K + + + A D G P LS+ ++ + + DVNDN P F+Q V
Sbjct: 453 KKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTE 512
Query: 3348 AVISEDALVGDSVILLIAEDVDSQPNGQIHFSIV-NGDRDNEFTVDPVLGLVKVKKKLDR 3406
E+ G+ + + A D DS N ++ +S+ FT+ P G ++VK LDR
Sbjct: 513 VAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDR 572
Query: 3407 ERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSIL 3466
E+ Y L V A D G P++ TATV +++ D NDN P F + Y + EN P + +
Sbjct: 573 EQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVG 632
Query: 3467 QLVVTDRDSFHNGPPFSFSILSGNEEEEFVL-DPHGILRSAVVFQHTESLEYVLCVQAKD 3525
+ V D D N + + +FV+ + G + S++ F + Y ++A D
Sbjct: 633 MVTVIDGDKGENA---QVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVD 689
Query: 3526 SGKPQQVSHTYIRVRVIEESTHKP--TAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--- 3580
G P + ++ + + V++E+ + P TA + G + ++ A D D
Sbjct: 690 GGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVN 749
Query: 3581 YDVLTFALKSEQKSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDGRFQVPIDVVVHV 3637
+++ LF++ SH G I ++ G + L V VSD R + P V
Sbjct: 750 AELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD-RGKPPRYGTALV 808
Query: 3638 EQLVHEMLQN 3647
V+E L N
Sbjct: 809 HLYVNETLAN 818
Score = 231 bits (589), Expect = 1e-59
Identities = 194/675 (28%), Positives = 298/675 (44%), Gaps = 58/675 (8%)
Query: 1028 EVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSG 1087
++EV D+N+N TP F + ++ EN+ IG+ A D D+G +G Y ++ G
Sbjct: 155 QIEVQDINDN--TPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212
Query: 1088 LGRF-------SIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVED 1140
+++ + LDRE SY LT+ D G P S+ + + V D
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD 272
Query: 1141 VNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNP--QNFFAI 1198
NDNAP P Y + ENSP SVIQ++A D D +N ++ Y + +
Sbjct: 273 TNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332
Query: 1199 NIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKV 1258
+ TGLIT +DRE + V D G +PK + VVV V D NDN P +
Sbjct: 333 DRNTGLITVQG-PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRG 391
Query: 1259 YQIKLPERDRKKRGEPIYRAFAF------DRDEGPNAEISYSIVDGNDDGKFFIDPKTGM 1312
+ + E + A DRDEG NA ++ +V G+ + +TG
Sbjct: 392 IGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT-CVVAGDVPFQLRQASETGS 450
Query: 1313 VSSRKQF----TAGSYD-----ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFD 1363
S +K F T Y+ + I AVD+G P SST L ++ + +P+ F
Sbjct: 451 DSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV---FT 507
Query: 1364 EPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAE-----KGV------ 1412
+ E+++ E++ ++ A++ G N + + E KG+
Sbjct: 508 QSVTEVAFPENNKPGEVIAEITASDADS-------GSNAELVYSLEPEPAAKGLFTISPE 560
Query: 1413 -GTIVIAKPLDAEQRSIYNMSVEVTDGTNVAV---TQVFIKVLDNNDNGPEFSQPNYDVT 1468
G I + LD EQR Y + V D + ++ V + VLD NDN P+F Y+ +
Sbjct: 561 TGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFS 620
Query: 1469 ISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEA 1528
+ E++ + + + D D+ + D+ F I TG + ++ D E
Sbjct: 621 VMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN---GDFVIQNGTGTILSSLSFDREQ 677
Query: 1529 QDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEAS--VFESAALGSAVL 1586
Q + + D P R V +NV D ND++PY T P + + LG V
Sbjct: 678 QSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVS 737
Query: 1587 QVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQ 1646
QV A D D G NAELIY+I GN +F+I G IT+ KE + G L +KV+D+
Sbjct: 738 QVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDR 797
Query: 1647 GSPPMSATAIVRISV 1661
G PP TA+V + V
Sbjct: 798 GKPPRYGTALVHLYV 812
Score = 208 bits (529), Expect = 1e-52
Identities = 213/796 (26%), Positives = 340/796 (42%), Gaps = 107/796 (13%)
Query: 1185 YRITSGNPQNFFAINIKTGLITTTSRKLDRE--QQAEHFL---------EVTVTDGGPSP 1233
Y++ G P + ++ KTG I TT +DRE ++ ++ L EV++TD +
Sbjct: 90 YKLEVGAP--YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNG 147
Query: 1234 KQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISY 1293
+ ++V D NDN P F V + +PE PI A DRD GPN SY
Sbjct: 148 SPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPI--PLASDRDAGPNGVASY 205
Query: 1294 SIVDGNDDGKFF----------IDPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTA 1343
+ G + + F P+ ++ + + SYD LTIK D G P ++S+A
Sbjct: 206 ELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYD-LTIKVQDGGSPPRASSA 264
Query: 1344 RLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVV----SVQPANTPLWFDIVG 1399
L + + +P F+ P Y + E+ + V V S Q AN + +
Sbjct: 265 LLRVTVLDTNDNAP---KFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEY---- 317
Query: 1400 GNFDSAFDA-------EKGVGTIVIAKPLDAEQRSIYNMSVEVTD-GTNV--AVTQVFIK 1449
F A + ++ G I + P+D E S SV D GTN A QV +
Sbjct: 318 -TFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVT 376
Query: 1450 VLDNNDNGPEF--------SQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTV---- 1497
V D NDN P + + ISEDV +T + ++ +DRDE + T
Sbjct: 377 VKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAG 436
Query: 1498 --------HSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNL 1549
S S S +K+ L T LD+E + + I+ D P +
Sbjct: 437 DVPFQLRQASETGSDSKKKY-------FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSST 489
Query: 1550 ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGN 1609
+ V V D ND++P FT + E + E+ G + ++TA D D G NAEL+Y++E
Sbjct: 490 NSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEP 549
Query: 1610 TGN-MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSH 1668
+F I P G I + D + L + D+GSP + TA V ++V +++
Sbjct: 550 AAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDND 609
Query: 1669 PKFIHKDYQAEVNENVDIGTSVILISAI-------SQSTLIYEVKDGDINGIFTINPYSG 1721
PKF+ Y V EN+ + V +++ I +Q L E +GD F I +G
Sbjct: 610 PKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD----FVIQNGTG 665
Query: 1722 VITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDENDNAPVFLFSQYSGSLS 1779
I + + D E+ S+Y ++A + + ++ V I ++DENDNAP ++ + + S
Sbjct: 666 TILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPSNTSHK 724
Query: 1780 EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANL 1839
P + ++ + A D DS NA L+Y I F + S +GAI +
Sbjct: 725 LLTPQTRLGETVSQ----VAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEI 780
Query: 1840 DHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETIL--LLPTY 1897
+ V V D G P + V + + T N + + ET+L L T
Sbjct: 781 ERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLAN-------RTLLETLLGHSLDTP 833
Query: 1898 VGVEVLKVSATDPDSE 1913
+ +++ A DP+ E
Sbjct: 834 LDIDI----AGDPEYE 845
Score = 196 bits (499), Expect = 3e-49
Identities = 192/723 (26%), Positives = 299/723 (41%), Gaps = 76/723 (10%)
Query: 2336 YFHIDSSSGLILTARM-LDHELVQHCTLKVRS--------------IDSGFPSLSSEVLV 2380
Y +D +G I T +D E ++ C ++ + +G P L
Sbjct: 98 YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEG--- 154
Query: 2381 HIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRT 2440
I + D+NDN P F + + E G ASD D+ Y + +G +
Sbjct: 155 QIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 2441 SFL--------MDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLF---TSTAQVHIRVLGA 2489
+ + +I + N ++R + Y L + V DG S+A + + VL
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDS-YDLTIKVQDGGSPPRASSALLRVTVLDT 273
Query: 2490 NLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIIN--DFAKDRFLID 2547
N +P F + +Y AE+ EN G VI V+A D D G +I Y + + +D
Sbjct: 274 NDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLD 333
Query: 2548 SNGQVITTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYR 2606
N +IT + +DRE+ S+ + ++ V V V D NDNAP T+E R
Sbjct: 334 RNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP---TIEIR 390
Query: 2607 -----------ASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDP 2655
A++ DV V VQ D D+G N+ +T + + + E
Sbjct: 391 GIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGS 450
Query: 2656 DNG-----WMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQ 2710
D+ T ++ ++K+ + + AVD G P S + + V+ P FTQ
Sbjct: 451 DSKKKYFLQTTTPLDYEKVKDYTIE--IVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508
Query: 2711 SQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGE-----RPENNKGGIFVIEQETGTI 2765
S E+ G + + + S N E PE G+F I ETG I
Sbjct: 509 SVTEVAFPENNKPGEVIAEITASDAD----SGSNAELVYSLEPEPAAKGLFTISPETGEI 564
Query: 2766 KLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIME 2825
++ LDRE ++ KV A + T V + VLD NDN P F S Y+ +ME
Sbjct: 565 QVKTSLDREQRESYELKVVAA-DRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVME 623
Query: 2826 GMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHET 2885
MP + + V ID D G N QV S+ D+ F I + TG I + D E
Sbjct: 624 NMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD------FVIQNGTGTILSSLSFDREQ 677
Query: 2886 DPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGN--VKESDPPGEVV 2943
T+TF + A D G S+ V++ V D NDNAP + + GE V
Sbjct: 678 QSTYTFQLKAVD-GGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETV 736
Query: 2944 AVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNIT 3003
+ ++ D D S VN ++ Y I GGNP G F +G + +++ ++R ++ L +
Sbjct: 737 SQVAAEDFD-SGVNAELIYSIAGGNPYGLFQIG--SHSGAITLEKEIERRHHGLHRLVVK 793
Query: 3004 ATD 3006
+D
Sbjct: 794 VSD 796
Score = 194 bits (492), Expect = 2e-48
Identities = 176/658 (26%), Positives = 297/658 (45%), Gaps = 85/658 (12%)
Query: 390 PPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTN 449
P GV ++ PE ++ + L ED + ++ L+ + + Y L +
Sbjct: 199 PNGVASYELQAGPEAQEL-FGLQVAEDQ-----EEKQPQLIVMGNLDRERWDSYDLTIKV 252
Query: 450 KEGDL-----KAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGEN 504
++G A + +++ D ND+ P+F++P Y+A ++E+ P+G SV+ V A+D D+G N
Sbjct: 253 QDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGAN 312
Query: 505 GYITYSIASLNLLPFVINQF------TGVISTTEELDFESSPEIYRFIVRASDWG-SPYR 557
I Y + + P V+ + TG+I+ +D E + RF V A D G +P
Sbjct: 313 AEIEY---TFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTL-RFSVLAKDRGTNPKS 368
Query: 558 HESEVNVTIRIGNVNDNSPLFEKVACQGV-----------ISYDFPVGGHITAVSAIDID 606
++V VT++ ++NDN+P E +G+ IS D + V D D
Sbjct: 369 ARAQVVVTVK--DMNDNAPTIE---IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRD 423
Query: 607 ELELVKYKIISGNELGFFYLNPDSGVLQLKK-SLTNSGIKNGNFALRITATDGENLADPM 665
E E + ++ F QL++ S T S K F T D E + D
Sbjct: 424 EGENAAVTCVVAGDVPF----------QLRQASETGSDSKKKYFLQTTTPLDYEKVKDYT 473
Query: 666 SINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYF 725
++V G S + + +V +N P F
Sbjct: 474 IEIVAVDSGNPPLSSTNSLKVQVV---------------------------DVNDNAPVF 506
Query: 726 DKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS-DGNTDSCFNIDMETGQLK 784
+S ++VA E+ G I +I A DADSG N ++++++ + F I ETG+++
Sbjct: 507 TQSV-TEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQ 565
Query: 785 VLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESS 844
V +DRE + Y L + D G+P + +NV D NDN P F+ Y+ +++E+
Sbjct: 566 VKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENM 625
Query: 845 GIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKI 904
+ + V D D G N +V SV D F I + TG + + DRE ++ Y+ ++
Sbjct: 626 PALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQL 685
Query: 905 EARDKAESGQQLFSVVTLKVFLDDVNDCSPAF-IPSSYSVKVL-EDLPVGTVIAWLETHD 962
+A D + + VT+ V D ND +P PS+ S K+L +G ++ + D
Sbjct: 686 KAVDGGVPPRSAYVGVTINVL--DENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAED 743
Query: 963 PDLGLGGQVRYSLV--NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
D G+ ++ YS+ N Y G F+I SGAI L KE++ + L V+ D+G+P
Sbjct: 744 FDSGVNAELIYSIAGGNPY-GLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP 800
Score = 184 bits (466), Expect = 2e-45
Identities = 183/656 (27%), Positives = 291/656 (44%), Gaps = 62/656 (9%)
Query: 1448 IKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHK--LSYTVHSSIDSIS 1505
I+V D NDN P F+ P + I E+ + A+DRD SY + + ++
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 1506 MRKFRI----DPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAND 1561
+ ++ + L LD E D + L I V+D P R + A + V V D ND
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275
Query: 1562 HSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGN--TGNMFKIEPV 1619
++P F P YEA + E++ +G +V+QV A D D+G NAE+ YT + +++
Sbjct: 276 NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRN 335
Query: 1620 LGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISV-TMSDNSHPKFI------ 1672
G+IT+ D + S+ D+G+ P SA A V ++V M+DN+ I
Sbjct: 336 TGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395
Query: 1673 -HKDYQAEVNENVDIGTSVIL-------------ISAISQSTLIYEVKDGDINGIFTINP 1718
H+D A ++E+V T+V L ++ + + ++++ G +
Sbjct: 396 THQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKK 455
Query: 1719 YSGVITTQKALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAPVFLFSQYSG 1776
Y + T LDYE+ Y + I A + ++S ++ +Q+VD NDNAPVF S
Sbjct: 456 Y--FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEV 513
Query: 1777 SLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQI-VESTAKKFFTVDSSTGAIRT 1835
+ E ++ I A+DADS NA LVY + E AK FT+ TG I+
Sbjct: 514 AFPENNKPGEVIAE-------ITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQV 566
Query: 1836 IANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILL-- 1893
+LD E + V D GSP L + V VN V D NDN P F + + ++
Sbjct: 567 KTSLDREQRESYELKVVAADRGSPSLQGTATVLVN--VLDCNDNDPKFMLSGYNFSVMEN 624
Query: 1894 LPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVL--TIKNNNLSKDHY 1951
+P V ++ V D +L+ G F+I + +G + ++ + + Y
Sbjct: 625 MPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD---FVIQNGTGTILSSLSFDREQQSTY 681
Query: 1952 MLIVKVSDGKFYSTSM---VTIMVKEAMDSGLHFTQSFYS-----TSISENNTNITKVAI 2003
+K DG S VTI V + D+ + T + T + +++VA
Sbjct: 682 TFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVA- 740
Query: 2004 VNAVGNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEAS 2057
+ +N L YSI NP F+I S SG I T +R L+ LVV+ S
Sbjct: 741 AEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAI-TLEKEIERRHHGLHRLVVKVS 795
Score = 181 bits (458), Expect = 2e-44
Identities = 162/556 (29%), Positives = 262/556 (47%), Gaps = 46/556 (8%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKV-NIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
L+RE D+Y L +K G A + + + VLD ND P F +Y ++E++P+
Sbjct: 238 LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 297
Query: 176 SVAQVTATDADIGSNGEFYYYFKNKVD----LFSVHPTSGVISLSGRLNYDEKNRYDLEI 231
SV QV A D+D G+N E Y F + L + +G+I++ G ++ ++ + +
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSV 357
Query: 232 LAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHV-----VTH------VPFSLEKEP 280
LA DR G N S+ A++ V ++ +N++APTI + VTH + + +E
Sbjct: 358 LAKDR-----GTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEET 412
Query: 281 TYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKE--GKWLNEYKIKERKQIDWESFP 338
A+V V D D+G N + +VAGD Q A E +Y ++ +D+E
Sbjct: 413 AVALVQVSDRDEGENAAV--TCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVK 470
Query: 339 YGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIV 398
Y + + A D G+P S D P+ F + V +V+ E + PG V+A +
Sbjct: 471 -DYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPV-FTQSVTEVAFPENNKPGEVIAEI 528
Query: 399 KLSP----EPIDVEYKLSPGEDAV-YFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGD 453
S ++ Y L P A F I+P +G I L+ ++E Y+L+V +
Sbjct: 529 TASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRG 588
Query: 454 L-----KAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYIT 508
A V +++ D ND+ P+F Y+ V E++P + V V+ D DKGEN +
Sbjct: 589 SPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQ 648
Query: 509 YSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRI 568
S+ N FVI TG I ++ D E Y F ++A D G P R + V VTI +
Sbjct: 649 LSVEQDN-GDFVIQNGTGTILSSLSFDREQQ-STYTFQLKAVDGGVPPR-SAYVGVTINV 705
Query: 569 GNVNDNSPLFEKVA--CQGVISYDFPVGGHITAVSAIDID---ELELVKYKIISGNELGF 623
+ NDN+P + +++ +G ++ V+A D D EL+ Y I GN G
Sbjct: 706 LDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELI-YSIAGGNPYGL 764
Query: 624 FYLNPDSGVLQLKKSL 639
F + SG + L+K +
Sbjct: 765 FQIGSHSGAITLEKEI 780
Score = 179 bits (454), Expect = 6e-44
Identities = 196/711 (27%), Positives = 305/711 (42%), Gaps = 72/711 (10%)
Query: 1823 FFTVDSSTGAIRTI-ANLDHETIAH-----------FHFHVHVRD---SGSPQLTAESPV 1867
+ VD TG I T ++D E + F V + D +GSP+L +
Sbjct: 98 YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRL-----L 152
Query: 1868 EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL 1927
E IEV D+NDN P F V + T +G A+D D+ +Y L G
Sbjct: 153 EGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212
Query: 1928 DHFLI---------DSNSGVLTIKNNNLSK-DHYMLIVKVSDGKF---YSTSMVTIMVKE 1974
L + ++ + N + + D Y L +KV DG S++++ + V +
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD 272
Query: 1975 AMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNR--LNEPLKYSILNPGNK----FKI 2028
D+ F + Y +SEN+ V V A + N ++Y+ ++
Sbjct: 273 TNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332
Query: 2029 KSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVF---- 2084
+G+I G P DRE+ V A + + AR V V ++D+NDN+P
Sbjct: 333 DRNTGLITVQG-PVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRG 391
Query: 2085 VGLPYY----AAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNS--GN 2138
+GL + A + D T + V D+D+G N VT V+ D F++ S G+
Sbjct: 392 IGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDV-PFQLRQASETGS 450
Query: 2139 VILKEAFNSDLSNI------EYGVTILAKDGGKPSLST--SVELPITIVNKAMPVFDKPF 2190
K+ F + + +Y + I+A D G P LS+ S+++ + VN PVF +
Sbjct: 451 DSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSV 510
Query: 2191 YTASVNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQ----FNIDFDTGVLKVVSPL 2246
+ E+ + I I A+ + ++ +P F I +TG ++V + L
Sbjct: 511 TEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL 570
Query: 2247 DYEVTSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTP 2305
D E +Y+L + A+D + TV + V D NDN P F YN ++ E +P
Sbjct: 571 DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSP 630
Query: 2306 VLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVR 2365
V V ID D N V + QD + F I + +G IL++ D E T +++
Sbjct: 631 VGMVTVIDGDKGENAQVQLSVEQDNGD----FVIQNGTGTILSSLSFDREQQSTYTFQLK 686
Query: 2366 SIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPR---GHFVTCVQASDAD 2422
++D G P S+ V V I + D NDN P S+ L P+ G V+ V A D D
Sbjct: 687 AVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSH-KLLTPQTRLGETVSQVAAEDFD 745
Query: 2423 SSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD 2473
S L YSI GN F + S SG ITL ++R L+ L V VSD
Sbjct: 746 SGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD 796
Score = 166 bits (419), Expect = 6e-40
Identities = 167/658 (25%), Positives = 278/658 (42%), Gaps = 49/658 (7%)
Query: 2153 EYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNT----PILSI 2208
E +T L ++G L +E + +N P F P T ++ E+ + + P+ S
Sbjct: 137 EVSITDLVQNGSPRLLEGQIE--VQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASD 194
Query: 2209 NATSPEGQGIIYIIIDGDPFKQFNIDFDTGV------LKVVSPLDYEVTSAYKLTIRASD 2262
P G + + + F + L V+ LD E +Y LTI+ D
Sbjct: 195 RDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQD 254
Query: 2263 ALTGARAE-VTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKM 2321
+ RA + + V D NDN P F++P+Y LSE S IG V+QV + D+D N
Sbjct: 255 GGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAE 314
Query: 2322 VHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVH 2381
+ Y Q +D ++GLI +D E + V + D G S+ V
Sbjct: 315 IEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVV 374
Query: 2382 IYISDVNDNPPVFN----QLIYE----SYVSELAPRGHFVTCVQASDADSSDFDRLEYSI 2433
+ + D+NDN P L+ + +SE V VQ SD D + + +
Sbjct: 375 VTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGE-NAAVTCV 433
Query: 2434 LSGNDRTSFLMDSKSGVITLSNHRKQRMEPL-------YSLNVSVSDG---LFTSTAQVH 2483
++G+ S++G + + Q PL Y++ + D +ST +
Sbjct: 434 VAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLK 493
Query: 2484 IRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIIND-FAKD 2542
++V+ N +P F+QS EN G + + A+D D G+ ++ Y++ + AK
Sbjct: 494 VQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKG 553
Query: 2543 RFLID-SNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFM 2601
F I G++ LDRE ++ + TV V V+D NDN P+FM
Sbjct: 554 LFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFM 613
Query: 2602 TVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMV 2661
Y SV ++ V V ID D G N+++ S+ + V I G ++
Sbjct: 614 LSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFV-----IQNGTGTIL 668
Query: 2662 TKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSF--TIAE 2719
+ +F++ + + +F +KAVDGG+P + + + V I+VL P T + +
Sbjct: 669 SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTP 728
Query: 2720 DTAIGSTVDTLRILPSQNVWFSTVNGER----PENNKGGIFVIEQETGTIKLDKRLDR 2773
T +G TV + + + S VN E N G+F I +G I L+K ++R
Sbjct: 729 QTRLGETVSQV----AAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIER 782
Score = 164 bits (414), Expect = 2e-39
Identities = 185/698 (26%), Positives = 302/698 (43%), Gaps = 77/698 (11%)
Query: 1757 IQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV 1816
I++ D NDN P F S ++ A P N+ + SL PL A+D D+ N + Y++
Sbjct: 156 IEVQDINDNTPNFA----SPVITLAIPENTNIGSLFPIPL---ASDRDAGPNGVASYELQ 208
Query: 1817 EST-AKKFFTV------DSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEV 1869
A++ F + + + + NLD E + + V+D GSP + + + V
Sbjct: 209 AGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRV 268
Query: 1870 NIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS--L 1927
V D NDN P F + +E L + +G V++V A D D E+ Y+ + +
Sbjct: 269 T--VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVV 326
Query: 1928 DHFL-IDSNSGVLTIKN----NNLSKDHYMLIVKVSDGKFYST-SMVTIMVKEAMDS--- 1978
L +D N+G++T++ +LS + ++ K S + V + VK+ D+
Sbjct: 327 RRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPT 386
Query: 1979 ------GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGN-KFKIKST 2031
GL T +ISE+ T VA+V E + + G+ F+++
Sbjct: 387 IEIRGIGL-VTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445
Query: 2032 SGV---------IQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSP 2082
S +QTT P D E+ + Y + + A + + ++V + D+NDN+P
Sbjct: 446 SETGSDSKKKYFLQTT-TPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAP 504
Query: 2083 VFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDD---YGHFEINPNSGNV 2139
VF A + +PG +I ++TA D D G N E+ Y L+ + G F I+P +G +
Sbjct: 505 VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEI 564
Query: 2140 ILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDI 2199
+K + + + Y + ++A D G PSL + + + +++ D F + N +
Sbjct: 565 QVKTSLDREQRE-SYELKVVAADRGSPSLQGTATVLVNVLD--CNDNDPKFMLSGYNFSV 621
Query: 2200 RMNTPILSINATSPEGQGIIYIIIDGDP---------FKQFNIDF----DTGVLKVVSPL 2246
N P LS P G + +IDGD +Q N DF TG +
Sbjct: 622 MENMPALS-----PVG---MVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSF 673
Query: 2247 DYEVTSAYKLTIRASDALTGAR-AEVTVDLLVNDVNDNPPIFDQP--TYNTTLSEASLIG 2303
D E S Y ++A D R A V V + V D NDN P P T + L+ + +G
Sbjct: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLG 733
Query: 2304 TPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLK 2363
V QV + D DS N + Y I N F I S SG I + ++ L
Sbjct: 734 ETVSQVAAEDFDSGVNAELIYSIAGG--NPYGLFQIGSHSGAITLEKEIERRHHGLHRLV 791
Query: 2364 VRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYES 2401
V+ D G P LVH+Y+++ N + L+ S
Sbjct: 792 VKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHS 829
Score = 145 bits (365), Expect = 1e-33
Identities = 145/576 (25%), Positives = 242/576 (42%), Gaps = 36/576 (6%)
Query: 2043 DREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTL 2102
DRE + Y+L ++ R + ++RV + D NDN+P F Y A + ++ G
Sbjct: 239 DRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHS 298
Query: 2103 IYQVTAIDKDKGPNGEVTYVLQDD----YGHFEINPNSGNVILKEAFN-SDLSNIEYGVT 2157
+ QV A D D+G N E+ Y ++ N+G + ++ + DLS + + +
Sbjct: 299 VIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRF--S 356
Query: 2158 ILAKDGGKPSLSTSVELPITI--VNKAMPVFD--------KPFYTASVNEDIRMNTPILS 2207
+LAKD G S ++ +T+ +N P + A+++ED+ T +
Sbjct: 357 VLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVAL 416
Query: 2208 INATS-PEGQ-GIIYIIIDGDPFKQFNIDFDTG-------VLKVVSPLDYEVTSAYKLTI 2258
+ + EG+ + ++ GD Q +TG L+ +PLDYE Y + I
Sbjct: 417 VQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEI 476
Query: 2259 RASDALTGARAEV-TVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSE 2317
A D+ + ++ + V DVNDN P+F Q E + G + ++ + DADS
Sbjct: 477 VAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSG 536
Query: 2318 NNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSE 2377
+N + Y + + + F I +G I LD E + LKV + D G PSL
Sbjct: 537 SNAELVYSLEPEP-AAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGT 595
Query: 2378 VLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGN 2437
V + + D NDN P F Y V E P V V D D + +++ S+
Sbjct: 596 ATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV--EQ 653
Query: 2438 DRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLF---TSTAQVHIRVLGANLYSP 2494
D F++ + +G I S + + Y+ + DG ++ V I VL N +P
Sbjct: 654 DNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP 713
Query: 2495 AFSQSTYVAE--VRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQV 2552
+ + + + G V V A D D G ++ Y+I F I S+
Sbjct: 714 YITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGA 773
Query: 2553 ITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRV 2588
IT E+ + E G + V+ D G + T V
Sbjct: 774 ITLEK-EIERRHHGLHRLVVKVSDRGKPPRYGTALV 808
Score = 122 bits (306), Expect = 8e-27
Identities = 166/725 (22%), Positives = 286/725 (39%), Gaps = 105/725 (14%)
Query: 146 IQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK---NKVD 202
I+V D+ND P F+ ++ I E+T + + A+D D G NG Y + +
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 203 LFSVHPTSG------VISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHI 256
LF + + + G L+ + + YDL I D G+ +S+A L V +
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDG-----GSPPRASSALLRVTV 270
Query: 257 ERINEHAPTIHVVTHVPFSLEKEPT-YAVVTV--DDLDDGANGEIESVSIVAGDPLDQFF 313
N++AP ++ E P ++V+ V +D D GAN EIE A + + +
Sbjct: 271 LDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLL 330
Query: 314 LAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVP 373
L I + +D E ++ AKD+G+ K + + V D P
Sbjct: 331 RLDRNTGL----ITVQGPVDREDLS-TLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP 385
Query: 374 IRFEKEVYDV-------SISEFSPPGVVVAIVKLSPEPI------------DVEYKLSPG 414
+ + V +ISE VA+V++S DV ++L
Sbjct: 386 TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQA 445
Query: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT-----NKEGDLKAQVTISIEDANDHT 469
+ + + + T PL+ K + Y +E+ N + + + D ND+
Sbjct: 446 SET--GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
Query: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI----ASLNLLPFVINQFT 525
P F Q + + E+ G + ++ASD D G N + YS+ A+ L F I+ T
Sbjct: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL--FTISPET 561
Query: 526 GVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQG 585
G I LD E E Y V A+D GSP + V + + + NDN P F
Sbjct: 562 GEIQVKTSLDREQR-ESYELKVVAADRGSP-SLQGTATVLVNVLDCNDNDPKFMLSGYNF 619
Query: 586 VISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIK 645
+ + P + V+ ID D+ E + ++ + G F + +G + SL+ +
Sbjct: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGT--ILSSLSFDREQ 677
Query: 646 NGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGK 705
+ ++ A DG P S + V
Sbjct: 678 QSTYTFQLKAVDGG--VPPRSAYVGV---------------------------------T 702
Query: 706 LNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLP---VGANILKIKAYDADSGFNGKVL 762
+N+ D N PY + PS+ + K P +G + ++ A D DSG N +++
Sbjct: 703 INVLDE-------NDNAPYI--TAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELI 753
Query: 763 FTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVE 822
++I+ GN F I +G + + ++R H L+ L + + D G P + L+ + V
Sbjct: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVN 813
Query: 823 DANDN 827
+ N
Sbjct: 814 ETLAN 818
Score = 82.4 bits (202), Expect = 9e-15
Identities = 94/401 (23%), Positives = 165/401 (41%), Gaps = 57/401 (14%)
Query: 120 EIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQ 179
+++D + IV L + + +QV+D+ND P+F+ + V E+ +A+
Sbjct: 468 KVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAE 527
Query: 180 VTATDADIGSNGEFYYYFKNK---VDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDR 236
+TA+DAD GSN E Y + + LF++ P +G I + L+ +++ Y+L+++A DR
Sbjct: 528 ITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADR 587
Query: 237 GMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANG 296
G+ + TA + V++ N++ P + + +E P + V + + DG G
Sbjct: 588 -----GSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 642
Query: 297 EIESVSI-VAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
E V + V D D G L+ +Q Y L+A D G P +
Sbjct: 643 ENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQST-------YTFQLKAVDGGVPPR 695
Query: 356 CSAL-----------KAVYIGNPTRD-----TVPIRFEKEVYDVSISEFSPPGVVVAIVK 399
+ + A YI P+ T R + V V+ +F GV ++
Sbjct: 696 SAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFD-SGVNAELI- 753
Query: 400 LSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVT 459
Y ++ G F+I SG I T++KE+ + G + V
Sbjct: 754 ---------YSIAGGNPYGLFQIGSHSGAI-------TLEKEIER----RHHGLHRLVVK 793
Query: 460 ISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKD 500
+S P + L YVNE++ T + T+ D
Sbjct: 794 VS---DRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLD 831
Score = 70.9 bits (172), Expect = 3e-11
Identities = 65/256 (25%), Positives = 115/256 (44%), Gaps = 21/256 (8%)
Query: 117 LNREIQDNYLLIVKGSVRGE-DLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
L+RE +++Y L V + RG L+ V + VLD ND P F + Y+ ++ E+ P +
Sbjct: 570 LDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALS 629
Query: 176 SVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
V VT D D G N + + F + +G I S + ++++ Y ++ AVD
Sbjct: 630 PVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVD 689
Query: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSL-----EKEPTYAVVTVDDL 290
G+ S+ + +++ N++AP I ++ L T + V +D
Sbjct: 690 GGVP-----PRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDF 744
Query: 291 DDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYG-YNLTLQAKD 349
D G N E+ SI G+P F + + K ER+ +G + L ++ D
Sbjct: 745 DSGVNAEL-IYSIAGGNPYGLFQIGSHSGAITLEKEIERRH-------HGLHRLVVKVSD 796
Query: 350 KGSPQKC-SALKAVYI 364
+G P + +AL +Y+
Sbjct: 797 RGKPPRYGTALVHLYV 812
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 273 bits (699), Expect = 2e-72
Identities = 199/653 (30%), Positives = 327/653 (50%), Gaps = 58/653 (8%)
Query: 718 INRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNID 777
IN P F + ++++ E+ + + A D D G NG + + + + F +D
Sbjct: 164 INDNAPLFPATV-INISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--KSQNIFGLD 220
Query: 778 M-------ETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPV 830
+ + QL V +DRE D Y++ + + D G PQ+SS +L ++V D NDN PV
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 280
Query: 831 FIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLT-----DTQQFAINSSTGI 885
F + V+I E++ +GT + Q+ A D D+G N ++ +S + F +N++TG+
Sbjct: 281 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 340
Query: 886 VYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAF------IPS 939
+ + + LDRE N+ L + A D G + + + V + DVND P+ P
Sbjct: 341 ITIKEPLDREETPNHKLLVLASD----GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 396
Query: 940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVR--------YSLVNDYNGRFEIDKASGA 991
+ +V + E++P+ T IA + D D G+V + L ++ +F ++ A+
Sbjct: 397 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-- 454
Query: 992 IRLSKELDYEKQQFYNLTVRAKDKGR-PVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVG 1050
LDYE + Y + + A D G+ P++ S++ F++V+ +EN + P F V
Sbjct: 455 -----YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK----DENDNAPVFTQSFVTV 505
Query: 1051 SVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRET 1110
S+ EN+ G +++V+A D DSG + EI Y + + FS+D +G++T LDRE
Sbjct: 506 SIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAP-PEFSLDRRTGMLTVVKKLDREK 564
Query: 1111 MGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI 1170
Y T+ A D GV PL S + V++ + D NDN+P+ + Y V EN P+ +V I
Sbjct: 565 EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLI 624
Query: 1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG 1230
DPD N +T I N F I+ +TG+I + DRE+Q + V DGG
Sbjct: 625 TVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVI-RPNISFDREKQESYTFYVKAEDGG 681
Query: 1231 PSPKQSTIWVVVQVLDENDNKPQF----PEKVYQIKLPERDRKKRGEPIYRAFAFDRDEG 1286
+ S+ V + V+D NDNKP F Y++ LP + G +++ A D D G
Sbjct: 682 RVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTN---PGTVVFQVIAVDNDTG 738
Query: 1287 PNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDI--LTIKAVDNGRP 1337
NAE+ YSIV GN F ID +TG ++ ++ + + +KA D G+P
Sbjct: 739 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791
Score = 259 bits (663), Expect = 3e-68
Identities = 200/697 (28%), Positives = 328/697 (47%), Gaps = 49/697 (7%)
Query: 2990 LDREEQDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIIL 3049
+ R+E Y + + + + D+NDN+P+ +PE+ N
Sbjct: 132 IPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYT 191
Query: 3050 KVSAKDADIGSNGYIRYSLYGSGNSEFFLD----PESGELKTLAL---LDRERIPVYSLM 3102
+A D D+G NG Y L S N F LD PE ++ L + LDRE Y +
Sbjct: 192 LPAAVDPDVGINGVQNYELIKSQNI-FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMK 250
Query: 3103 AKATDGGGRFCQSNIHLILE----DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDP 3158
K DGG F Q + IL+ D NDN PVF + EN +T++ A D
Sbjct: 251 VKVEDGG--FPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 308
Query: 3159 DIGINRKVVYSLADSAGGV----FSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQ 3214
DIG N K+ +S ++ + F +++++G+I +++PLDRE+ ++ + V A+D G
Sbjct: 309 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD---GG 365
Query: 3215 SLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSP-------GTQVLAVFATSKDIGT 3267
+ + V + V D+NDN P + R Y+V DT T++ + T KD
Sbjct: 366 LMPARAMVLVNVTDVNDNVPSIDIR-YIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424
Query: 3268 NAEITYLIRSGNEQGKFKINPKTGGISVSE---VLDYELCKRFYLVVEAKDGGTPALSAV 3324
N +T + + F++ P + E LDYE K + + + A D G P L+
Sbjct: 425 NGRVTCFT---DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQS 481
Query: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGD 3384
A + I + D NDN P F+Q + I E+ G ++ + A D DS PN +I++ ++ D
Sbjct: 482 AMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPD 540
Query: 3385 RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSP 3444
EF++D G++ V KKLDRE+ Y + A D+G+P ++S TV + I D NDNSP
Sbjct: 541 APPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSP 600
Query: 3445 VFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH-GIL 3503
VFT Y + EN P ++ + VTD D + + + SIL +E ++F +D G++
Sbjct: 601 VFTHNEYKFYVPENLPRHGTVGLITVTDPD-YGDNSAVTLSIL--DENDDFTIDSQTGVI 657
Query: 3504 RSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAI--PLEI-FIVT 3560
R + F + Y V+A+D G+ + S + + V++ + +KP I P + +
Sbjct: 658 RPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELV 717
Query: 3561 MEDDFPGGVIGKIHATDQDM---YDVLTFALKSEQKSLFKVNSHDGKIIAL---GGLDSG 3614
+ PG V+ ++ A D D +V + + LF ++ G I + D G
Sbjct: 718 LPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 777
Query: 3615 KYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTI 3651
+ + V +D + VV V V+E + N I
Sbjct: 778 LHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI 814
Score = 244 bits (624), Expect = 1e-63
Identities = 195/706 (27%), Positives = 332/706 (47%), Gaps = 47/706 (6%)
Query: 814 WRLLTIN--VEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL 871
+RL+ I +ED NDN+P+F +++I E+S I ++ A D D+G NG Y ++
Sbjct: 152 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 211
Query: 872 TDTQQFAIN-------SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKV 924
F ++ + V +LDRE K Y +K++ D Q S L+V
Sbjct: 212 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVED--GGFPQRSSTAILQV 269
Query: 925 FLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYS---LVNDYNG 981
+ D ND P F + V + E+ PVGT + L D D+G ++ +S LV++
Sbjct: 270 SVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 329
Query: 982 R-FEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHT 1040
R F ++ +G I + + LD E+ + L V A D G + + + V V V DVN+N+
Sbjct: 330 RLFHLNATTGLITIKEPLDREETPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNV-- 384
Query: 1041 PYFPDFAVVGSV------KENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
P +V V EN + T + +T D+D+ +G + +
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 444
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
++ A LD E+ Y + + A D G PL + ++I+V+D NDNAP+ ++
Sbjct: 445 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 504
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+ EN+ + ++++ A D DS N ++ Y + P F+++ +TG++T +KLDR
Sbjct: 505 VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE-FSLDRRTGMLTVV-KKLDR 562
Query: 1215 EQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEP 1274
E++ ++ + D G P S + V V ++D+NDN P F Y+ +PE R
Sbjct: 563 EKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE--NLPRHGT 620
Query: 1275 IYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILT--IKAV 1332
+ D D G N+ ++ SI+D NDD F ID +TG++ F + T +KA
Sbjct: 621 VGLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAE 678
Query: 1333 DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFT---VMESDR----VTEIVGVVS 1385
D GR +SS+A++ I + P+ F P YN++ V+ S V +++ V +
Sbjct: 679 DGGRVSRSSSAKVTINVVDVNDNKPV---FIVPPYNYSYELVLPSTNPGTVVFQVIAVDN 735
Query: 1386 VQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD-GTNVAVT 1444
N + + IVGGN F ++ G I + + D ++ + V+ D G ++
Sbjct: 736 DTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 795
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDV--TISEDVLPDTEILQIEATDRD 1488
V I L N++ + N V +I V P+TEI + + D
Sbjct: 796 SVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 226 bits (576), Expect = 4e-58
Identities = 189/668 (28%), Positives = 316/668 (47%), Gaps = 46/668 (6%)
Query: 915 QLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYS 974
++F +V ++ ++D+ND +P F + ++ + E+ + + DPD+G+ G Y
Sbjct: 150 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 209
Query: 975 LVNDYN--GRFEIDKASG----AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVE 1028
L+ N G I+ G + + KELD E++ Y + V+ +D G P SS + ++
Sbjct: 210 LIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQ 268
Query: 1029 VEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD-GSG 1087
V V D N+N P F + + S+ EN+ +GTSV Q+ A D D G + +I +S + S
Sbjct: 269 VSVTDTNDN--HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 326
Query: 1088 LGR--FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1145
+ R F ++ +G+IT + LDRE ++ L V A+D G++P + V + V DVNDN
Sbjct: 327 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNV 384
Query: 1146 PLTS-----EPIYYPVVM-ENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAIN 1199
P P+ VV+ EN P + + I D D+ N ++T P +
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPV- 443
Query: 1200 IKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVY 1259
+ + LD E E+ +++ D G P + + ++V DENDN P F +
Sbjct: 444 FSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503
Query: 1260 QIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF 1319
+ +PE + G + + A D D GPNAEI+Y ++ + +F +D +TGM++ K+
Sbjct: 504 TVSIPENN--SPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKL 560
Query: 1320 TAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV 1377
D + TI A DNG P +S + + I + SP+ F Y F V E+
Sbjct: 561 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPV---FTHNEYKFYVPENLPR 617
Query: 1378 TEIVGVVSVQPA----NTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSV 1433
VG+++V N+ + I+ N D D++ GV I+ D E++ Y V
Sbjct: 618 HGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNIS--FDREKQESYTFYV 675
Query: 1434 EVTDGTNV---AVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTE----ILQIEATD 1486
+ DG V + +V I V+D NDN P F P Y+ + E VLP T + Q+ A D
Sbjct: 676 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSY-ELVLPSTNPGTVVFQVIAVD 734
Query: 1487 RDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYR 1546
D +S + + F ID TG + E+ D D + ++V+ +
Sbjct: 735 NDTGMNAEVR-YSIVGGNTRDLFAIDQETGNITLMEKCD--VTDLGLHRVLVKANDLGQP 791
Query: 1547 RNLARVIV 1554
+L V++
Sbjct: 792 DSLFSVVI 799
Score = 216 bits (549), Expect = 5e-55
Identities = 185/699 (26%), Positives = 311/699 (44%), Gaps = 37/699 (5%)
Query: 2271 VTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDT 2330
V + L+ D+NDN P+F N ++ E S I + ++D D N + +Y++++
Sbjct: 155 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-- 212
Query: 2331 YNSTDYFHID-------SSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIY 2383
S + F +D ++ + LD E +KV+ D GFP SS ++ +
Sbjct: 213 --SQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 270
Query: 2384 ISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYS---ILSGNDRT 2440
++D NDN PVF + E + E AP G VT + A+DAD + ++ +S ++S R
Sbjct: 271 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 2441 SFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG-LFTSTAQVHIRVLGANLYSPAFSQS 2499
F +++ +G+IT+ + P + L V SDG L + A V + V N P+
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 390
Query: 2500 TYVAEVR------ENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVI 2553
V V EN+ TK+ + TD D G+++ ++ + SN ++
Sbjct: 391 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 450
Query: 2554 TTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRAD 2612
LD E+ E + + + + V DENDNAP F S+ +
Sbjct: 451 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 2613 VGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNT 2672
G + +V A D D G N+ I Y L +A + +D G + ++ K
Sbjct: 511 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFS----LDRRTGMLTVVKKLDREKED 566
Query: 2673 VLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRI 2732
F + A D G+P S + V++ ++ P FT ++Y F + E+ TV + +
Sbjct: 567 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITV 626
Query: 2733 LPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKV 2792
S V + N F I+ +TG I+ + DRE ++ F V A +V
Sbjct: 627 TDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDG-GRV 683
Query: 2793 DIVFTVDVDIKVLDLNDNKPVFETSSYD---TIIMEGMPVGTKLTQVRAIDMDWGANGQV 2849
+ V I V+D+NDNKPVF Y+ +++ GT + QV A+D D G N +V
Sbjct: 684 SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEV 743
Query: 2850 TYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTAL 2909
YS+ + + F ID TG I+ ++ D V A+DLG+ SL S +
Sbjct: 744 RYSIVGGN----TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 799
Query: 2910 VSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLST 2948
V++ V + NA + E+ R +++ P +A +S+
Sbjct: 800 VNLFVNESVTNATLI-NELVRKSIEAPVTPNTEIADVSS 837
Score = 215 bits (548), Expect = 7e-55
Identities = 189/663 (28%), Positives = 304/663 (45%), Gaps = 74/663 (11%)
Query: 429 IVTARPLNTVKKEVYKLEVTNKEGDLK-----AQVTISIEDANDHTPEFQQPLYDAYVNE 483
++ + L+ +K+ Y ++V ++G A + +S+ D ND+ P F++ + + E
Sbjct: 233 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 292
Query: 484 SVPVGTSVLTVSASDKDKGENGYITYSIASL--NLLP--FVINQFTGVISTTEELDFESS 539
+ PVGTSV + A+D D GEN I +S ++L N+ F +N TG+I+ E LD E +
Sbjct: 293 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 352
Query: 540 PEIYRFIVRASDWG-SPYRHESEVNVTIRIGNVNDNSP------LFEKVACQGVISYDFP 592
P ++ +V ASD G P R VNVT +VNDN P + V V+S + P
Sbjct: 353 PN-HKLLVLASDGGLMPARAMVLVNVT----DVNDNVPSIDIRYIVNPVNDTVVLSENIP 407
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ I ++ D D + + +E+ F S L+ + +A++
Sbjct: 408 LNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 467
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ A D A +N S + L IK K
Sbjct: 468 LLAAD----AGKPPLNQSAM-----------------------LFIKVKDE--------- 491
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
N P F +SF + V++ E+ G ++K+ A DADSG N ++ + +
Sbjct: 492 ------NDNAPVFTQSFVT-VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE 544
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFI 832
F++D TG L V+ +DRE D YL I D G P +S + +++ D NDNSPVF
Sbjct: 545 -FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 603
Query: 833 QDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQL 892
+ Y + E+ + + D D G N VT S+L + F I+S TG++
Sbjct: 604 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 893 DRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI--PSSYSVK-VLEDL 949
DRE + +Y+ ++A D + + VT+ V DVND P FI P +YS + VL
Sbjct: 664 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVV--DVNDNKPVFIVPPYNYSYELVLPST 721
Query: 950 PVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNL 1008
GTV+ + D D G+ +VRYS+V + F ID+ +G I L ++ D + +
Sbjct: 722 NPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRV 781
Query: 1009 TVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAR 1068
V+A D G+P SL SV V + VNE++ + V S++ T + V++
Sbjct: 782 LVKANDLGQPDSLFSVVIVN---LFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSP 838
Query: 1069 DED 1071
D
Sbjct: 839 TSD 841
Score = 214 bits (544), Expect = 2e-54
Identities = 218/804 (27%), Positives = 351/804 (43%), Gaps = 68/804 (8%)
Query: 1150 EPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS 1209
E I V++ N KD+++ I + ++ KL Y+ T P I TG I TT
Sbjct: 64 EEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYK-TGDVP--LIRIEEDTGEIFTTG 120
Query: 1210 RKLDREQ------QAEH-FLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIK 1262
++DRE+ + EH F EV V P + + + D NDN P FP V I
Sbjct: 121 ARIDREKLCAGIPRDEHCFYEVEVAIL-PDEIFRLVKIRFLIEDINDNAPLFPATVINIS 179
Query: 1263 LPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDG-NDDGKFFIDPKTG----MVSSRK 1317
+PE + A D D G N +Y ++ N G I+ G + +K
Sbjct: 180 IPENSAINSKYTL--PAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQK 237
Query: 1318 QFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESD 1375
+ D ++ +K D G PQ+SSTA L + P+ F E ++ E+
Sbjct: 238 ELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV---FKETEIEVSIPENA 294
Query: 1376 RVTEIVGVVSVQPA----NTPLWF---DIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSI 1428
V V + A N + F ++V F G I I +PLD E+
Sbjct: 295 PVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN 354
Query: 1429 YNMSVEVTDGTNV-AVTQVFIKVLDNNDNGPEF------SQPNYDVTISEDVLPDTEILQ 1481
+ + V +DG + A V + V D NDN P + N V +SE++ +T+I
Sbjct: 355 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 414
Query: 1482 IEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 1541
I TD+D H T + + I R + + +L A LD+E+ ++ + ++ D
Sbjct: 415 ITVTDKDADHNGRVTCFTDHE-IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADA 473
Query: 1542 EFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAEL 1601
P A + + V+D ND++P FT S+ E+ + G +++V+A D D G NAE+
Sbjct: 474 GKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEI 533
Query: 1602 IYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661
Y + + F ++ G++T+ K+ D +++ +I D G PP+++ V +S+
Sbjct: 534 NYLL-GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 592
Query: 1662 TMSDNSHPKFIHKDYQAEVNENVDIGTSVILI----------SAISQSTLIYEVKDGDIN 1711
+++ P F H +Y+ V EN+ +V LI SA++ S L D N
Sbjct: 593 IDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL-------DEN 645
Query: 1712 GIFTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDENDNAPVF 1769
FTI+ +GVI + D E+ SY ++A + +S+A V I +VD NDN PVF
Sbjct: 646 DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF 705
Query: 1770 LFSQYSGSLSEAAPINSIVRSLDNSPLVIR--ATDADSNRNALLVYQIVESTAKKFFTVD 1827
+ Y+ S P S + +V + A D D+ NA + Y IV + F +D
Sbjct: 706 IVPPYNYSYELVLP------STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAID 759
Query: 1828 SSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAV 1887
TG I + D + V D G P + S V VN+ V + N + + V
Sbjct: 760 QETGNITLMEKCDVTDLGLHRVLVKANDLGQPD-SLFSVVIVNLFVNESVTNATLINELV 818
Query: 1888 FETILLLPTYVGVEVLKVSATDPD 1911
++I P E+ VS+ D
Sbjct: 819 RKSI-EAPVTPNTEIADVSSPTSD 841
Score = 205 bits (521), Expect = 1e-51
Identities = 198/700 (28%), Positives = 315/700 (45%), Gaps = 56/700 (8%)
Query: 2027 KIKSTSGVIQTTGVPFDRE---------EQELYELVVEASRELDHLRVARVV-VRVNIED 2076
+I+ +G I TTG DRE E YE+ V + + R+V +R IED
Sbjct: 108 RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD----EIFRLVKIRFLIED 163
Query: 2077 INDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL---QDDYGHFEIN 2133
INDN+P+F ++ ++ + A+D D G NG Y L Q+ +G I
Sbjct: 164 INDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIE 223
Query: 2134 PNSGNVILKEAFNSDLSNIE---YGVTILAKDGGKPSLSTS--VELPITIVNKAMPVFDK 2188
G+ + + +L E Y + + +DGG P S++ +++ +T N PVF +
Sbjct: 224 TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKE 283
Query: 2189 PFYTASVNEDIRMNTPILSINATSPE-GQGI-----IYIIIDGDPFKQFNIDFDTGVLKV 2242
S+ E+ + T + ++AT + G+ ++ + F+++ TG++ +
Sbjct: 284 TEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITI 343
Query: 2243 VSPLDYEVTSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFD-----QPTYNT-T 2295
PLD E T +KL + ASD L ARA V V+ V DVNDN P D P +T
Sbjct: 344 KEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVV 401
Query: 2296 LSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHE 2355
LSE + T + + D D+++N V D + S+ L+ A LD+E
Sbjct: 402 LSENIPLNTKIALITVTDKDADHNGRV--TCFTDHEIPFRLRPVFSNQFLLENAAYLDYE 459
Query: 2356 LVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTC 2415
+ +K+ + D+G P L+ ++ I + D NDN PVF Q + E G +
Sbjct: 460 STKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMK 519
Query: 2416 VQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG- 2474
V A+DADS + Y +L + F +D ++G++T+ + E Y + D
Sbjct: 520 VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNG 578
Query: 2475 --LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQIS 2532
TS V + ++ N SP F+ + Y V EN+ V + TD D G ++
Sbjct: 579 VPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVT 638
Query: 2533 YAIINDFAKDRFLIDSNGQVITTE-RLDRENPLEGDVSIFVRALDGG--GRTTFCTVRVI 2589
+I+++ D F IDS VI DRE + + +V+A DGG R++ V +
Sbjct: 639 LSILDE--NDDFTIDSQTGVIRPNISFDREK--QESYTFYVKAEDGGRVSRSSSAKVTIN 694
Query: 2590 VVDENDNAPQFMTVEYRAS---VRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVS 2646
VVD NDN P F+ Y S V G +V QV A+D D G N+ + YS+ +
Sbjct: 695 VVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI---VGGN 751
Query: 2647 VADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIP 2686
DL ID + G + + + VKA D G P
Sbjct: 752 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791
Score = 202 bits (514), Expect = 6e-51
Identities = 182/698 (26%), Positives = 309/698 (44%), Gaps = 46/698 (6%)
Query: 1951 YMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNR 2010
Y + V + + + + ++++ D+ F + + SI EN+ +K + AV
Sbjct: 140 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 199
Query: 2011 --LNEPLKYSILNPGNKFKI---------KSTSGVIQTTGVPFDREEQELYELVVEASRE 2059
+N Y ++ N F + K ++Q DREE++ Y + V+
Sbjct: 200 VGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE---LDREEKDTYVMKVKVEDG 256
Query: 2060 LDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEV 2119
R + +++V++ D NDN PVF ++ +A GT + Q+ A D D G N ++
Sbjct: 257 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 316
Query: 2120 TYVLQDDYGH-----FEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVEL 2174
+ + + F +N +G + +KE + + + + +LA DGG V +
Sbjct: 317 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDRE-ETPNHKLLVLASDGGLMPARAMVLV 375
Query: 2175 PITIVNKAMPVFDKPFYTASVN------EDIRMNTPILSINATSPEGQ--GIIYIIIDGD 2226
+T VN +P D + VN E+I +NT I I T + G + D +
Sbjct: 376 NVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHE 435
Query: 2227 -PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDA-LTGARAEVTVDLLVNDVNDNP 2284
PF+ + + +L+ + LDYE T Y + + A+DA + + V D NDN
Sbjct: 436 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495
Query: 2285 PIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSG 2344
P+F Q ++ E + G +++V + DADS N ++Y + D + F +D +G
Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPD---APPEFSLDRRTG 552
Query: 2345 LILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVS 2404
++ + LD E + + D+G P L+S V V + I D NDN PVF Y+ YV
Sbjct: 553 MLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVP 612
Query: 2405 ELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPL 2464
E PR V + +D D D + SIL ND F +DS++GVI + + +
Sbjct: 613 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQES 670
Query: 2465 YSLNVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTY---VAEVRENVAAGTKVIHV 2518
Y+ V DG +S+A+V I V+ N P F Y V + GT V V
Sbjct: 671 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730
Query: 2519 RATDGDPGTYGQISYAIINDFAKDRFLID-SNGQVITTERLDRENPLEGDVSIFVRALDG 2577
A D D G ++ Y+I+ +D F ID G + E+ D + G + V+A D
Sbjct: 731 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTD--LGLHRVLVKANDL 788
Query: 2578 GGRTTFCTVRVIVVDENDNAPQFMTVE--YRASVRADV 2613
G + +V ++ + N++ + R S+ A V
Sbjct: 789 GQPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826
Score = 195 bits (496), Expect = 8e-49
Identities = 190/680 (27%), Positives = 299/680 (43%), Gaps = 65/680 (9%)
Query: 2465 YSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGD 2524
Y + V++ ++ + N +P F + + EN A +K A D D
Sbjct: 140 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 199
Query: 2525 PGTYGQISYAII---NDFAKDRFLI---DSNGQVITTERLDRENPLEGDVSIFVRALDGG 2578
G G +Y +I N F D D Q+I + LDRE E D + ++ G
Sbjct: 200 VGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE---EKDTYVMKVKVEDG 256
Query: 2579 G---RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRI 2635
G R++ ++V V D NDN P F E S+ + G VTQ+ A D D G N++I
Sbjct: 257 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 316
Query: 2636 TYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVY 2695
+S + S L ++ G + K ++ + V A DGG+ ++ V
Sbjct: 317 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VL 374
Query: 2696 IHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGI 2755
++V +PS +Y DT + S I + + TV + ++N
Sbjct: 375 VNVTDVNDNVPSI-DIRYIVNPVNDTVVLSE----NIPLNTKIALITVTDKDADHNGRVT 429
Query: 2756 FVIEQE---------TGTIKLDKR--LDRETSPAFHFKV----AATIPLDKVDIVFTVDV 2800
+ E + L+ LD E++ + K+ A PL++ ++F
Sbjct: 430 CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF---- 485
Query: 2801 DIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPE 2860
IKV D NDN PVF S I E G +L +V A D D G N ++ Y L D+ PE
Sbjct: 486 -IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE 544
Query: 2861 KVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDN 2920
F++D TG ++ +K LD E + + F+++A D G L+S V V + D NDN
Sbjct: 545 -----FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDN 598
Query: 2921 APVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQS 2980
+PVF Y+ V E+ P V +++ D D D N V+ I N F +
Sbjct: 599 SPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSILDEN--DDFTI----- 650
Query: 2981 EWKVYVKRP---LDREEQDIYFLNITATDGLFVTQ---AMVEVSVSDVNDNSPVC----D 3030
+ + V RP DRE+Q+ Y + A DG V++ A V ++V DVNDN PV
Sbjct: 651 DSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPY 710
Query: 3031 QVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLA 3089
+Y +LP P ++ +V A D D G N +RYS+ G + F +D E+G + +
Sbjct: 711 NYSYELVLPSTNPGT-VVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLME 769
Query: 3090 LLDRERIPVYSLMAKATDGG 3109
D + ++ ++ KA D G
Sbjct: 770 KCDVTDLGLHRVLVKANDLG 789
Score = 180 bits (457), Expect = 3e-44
Identities = 188/676 (27%), Positives = 317/676 (46%), Gaps = 66/676 (9%)
Query: 1424 EQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIE 1483
++ Y + V + + ++ + D NDN P F +++I E+ +++
Sbjct: 135 DEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPA 194
Query: 1484 ATDRD------EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIM 1537
A D D + ++L + +I + + + L + LD E +D +++ +
Sbjct: 195 AVDPDVGINGVQNYELIKS--QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 252
Query: 1538 VRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGE 1597
V D FP R + A + V+V D ND+ P F E S+ E+A +G++V Q+ A D D GE
Sbjct: 253 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 312
Query: 1598 NAELIYT---IEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSAT 1654
NA++ ++ + + +F + G+ITI + D L + +D G P A
Sbjct: 313 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--AR 370
Query: 1655 AIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDGDING-- 1712
A+V ++VT +++ P + VN+ V + ++ L + I+ T+ KD D NG
Sbjct: 371 AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV--TDKDADHNGRV 428
Query: 1713 --------IFTINP-YSGVITTQKA--LDYERTSSYQLIIQATNMA--GMASNATVNIQI 1759
F + P +S + A LDYE T Y + + A + + +A + I++
Sbjct: 429 TCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKV 488
Query: 1760 VDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSP----LVIRATDADSNRNALLVYQI 1815
DENDNAPVF S + S+ E +NSP + + ATDADS NA + Y +
Sbjct: 489 KDENDNAPVFTQSFVTVSIPE-----------NNSPGIQLMKVSATDADSGPNAEINY-L 536
Query: 1816 VESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTD 1875
+ A F++D TG + + LD E + F + +D+G P LT S V V + + D
Sbjct: 537 LGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLT--SNVTVFVSIID 594
Query: 1876 VNDNPPVFTQAVFETIL--LLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLID 1933
NDN PVFT ++ + LP + V ++ V TDPD +T S+++ + D F ID
Sbjct: 595 QNDNSPVFTHNEYKFYVPENLPRHGTVGLITV--TDPDYGDNSAVTLSILDEN-DDFTID 651
Query: 1934 SNSGVL--TIKNNNLSKDHYMLIVKVSDG---KFYSTSMVTIMVKEAMDSGLHFTQSFYS 1988
S +GV+ I + ++ Y VK DG S++ VTI V + D+ F Y+
Sbjct: 652 SQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYN 711
Query: 1989 TS---ISENNTNITKVAIVNAVGN--RLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVP 2041
S + + T V V AV N +N ++YSI+ N + F I +G I T
Sbjct: 712 YSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI-TLMEK 770
Query: 2042 FDREEQELYELVVEAS 2057
D + L+ ++V+A+
Sbjct: 771 CDVTDLGLHRVLVKAN 786
Score = 177 bits (449), Expect = 2e-43
Identities = 163/563 (28%), Positives = 264/563 (46%), Gaps = 58/563 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKV-NIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
L+RE +D Y++ VK G + T + + V D ND P+F T V+I E+ P+ T
Sbjct: 239 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 298
Query: 176 SVAQVTATDADIGSNGEFYYYFKNKVD-----LFSVHPTSGVISLSGRLNYDEKNRYDLE 230
SV Q+ ATDADIG N + ++ F N V LF ++ T+G+I++ L+ +E + L
Sbjct: 299 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 358
Query: 231 ILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHV------VTHVPFSLEKEP---T 281
+LA D G+ + + A + V++ +N++ P+I + V E P
Sbjct: 359 VLASDGGL-------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 411
Query: 282 YAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGY 341
A++TV D D NG + + D F L + N++ ++ +D+ES Y
Sbjct: 412 IALITVTDKDADHNGRVTCFT----DHEIPFRL--RPVFSNQFLLENAAYLDYES-TKEY 464
Query: 342 NLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLS 401
+ L A D G P + D P+ F + VSI E + PG + ++K+S
Sbjct: 465 AIKLLAADAGKPPLNQSAMLFIKVKDENDNAPV-FTQSFVTVSIPENNSPG--IQLMKVS 521
Query: 402 PEPID------VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDL- 454
D + Y L P + F ++ R+G++ + L+ K++ Y + K+ +
Sbjct: 522 ATDADSGPNAEINYLLGP-DAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 580
Query: 455 ----KAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYS 510
V +SI D ND++P F Y YV E++P +V ++ +D D G+N +T S
Sbjct: 581 PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 640
Query: 511 IASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGN 570
I N F I+ TGVI D E E Y F V+A D G R S VTI + +
Sbjct: 641 ILDEN-DDFTIDSQTGVIRPNISFDREKQ-ESYTFYVKAEDGGRVSR-SSSAKVTINVVD 697
Query: 571 VNDNSPLFEKVACQGVISYDFPV-----GGHITAVSAIDIDE--LELVKYKIISGNELGF 623
VNDN P+F + SY+ + G + V A+D D V+Y I+ GN
Sbjct: 698 VNDNKPVF--IVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL 755
Query: 624 FYLNPDSGVLQL--KKSLTNSGI 644
F ++ ++G + L K +T+ G+
Sbjct: 756 FAIDQETGNITLMEKCDVTDLGL 778
Score = 135 bits (341), Expect = 7e-31
Identities = 170/722 (23%), Positives = 305/722 (42%), Gaps = 90/722 (12%)
Query: 129 VKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIG 188
V+ ++ +++ K+ + D+ND PLF T +++I E++ + + A D D+G
Sbjct: 142 VEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVG 201
Query: 189 SNGEFYYYFKNKVDLFS---VHPTSG----VISLSGRLNYDEKNRYDLEILAVDRGMKLY 241
NG Y ++F + G + + L+ +EK+ Y +++ D G
Sbjct: 202 INGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR 261
Query: 242 GNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSL-EKEPTYAVVT---VDDLDDGANGE 297
SSTA L V + N++ P + T + S+ E P VT D D G N +
Sbjct: 262 -----SSTAILQVSVTDTNDNHP-VFKETEIEVSIPENAPVGTSVTQLHATDADIGENAK 315
Query: 298 IE-SVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKG-SPQK 355
I S S + + + F L I ++ +D E P + L + A D G P +
Sbjct: 316 IHFSFSNLVSNIARRLFHLNATTGL----ITIKEPLDREETP-NHKLLVLASDGGLMPAR 370
Query: 356 CSALKAVYIGNPTRDTVPIRF-EKEVYD-VSISEFSPPGVVVAIVKLSPEPIDVEYKLSP 413
L V N ++ IR+ V D V +SE P +A++ ++ + D +++
Sbjct: 371 AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC 430
Query: 414 GED-AVYFKINP---RSGLIVTARPLNTVKKEVYKLEVTNKEG-----DLKAQVTISIED 464
D + F++ P L+ A L+ + Y +++ + + A + I ++D
Sbjct: 431 FTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKD 490
Query: 465 ANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQF 524
ND+ P F Q + E+ G ++ VSA+D D G N I Y + F +++
Sbjct: 491 ENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRR 550
Query: 525 TGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
TG+++ ++LD E + Y F + A D G P S V V + I + NDNSP+F +
Sbjct: 551 TGMLTVVKKLDREKEDK-YLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYK 608
Query: 585 GVISYDFPVGGHITAVSAIDID--ELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNS 642
+ + P G + ++ D D + V I+ N+ F ++ +GV++ S
Sbjct: 609 FYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDRE 666
Query: 643 GIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKA 702
K ++ + A DG G+VS S A
Sbjct: 667 --KQESYTFYVKAEDG---------------GRVSRSS--------------------SA 689
Query: 703 NGKLNLEDGFLDFYSINRQGPYF---DKSFPSDVAVKEDLPVGANILKIKAYDADSGFNG 759
+N+ D +N P F ++ ++ + P G + ++ A D D+G N
Sbjct: 690 KVTINVVD-------VNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNA 741
Query: 760 KVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTI 819
+V ++I GNT F ID ETG + ++ D L+ + + DLG P S + ++ +
Sbjct: 742 EVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD-SLFSVVIV 800
Query: 820 NV 821
N+
Sbjct: 801 NL 802
Score = 126 bits (316), Expect = 6e-28
Identities = 133/492 (27%), Positives = 216/492 (43%), Gaps = 38/492 (7%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMND------LRPLFSPTTYSVTIAES 170
L+RE N+ L+V S G + A V + V D+ND +R + +P +V ++E+
Sbjct: 347 LDREETPNHKLLVLASDGGL-MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSEN 405
Query: 171 TPLRTSVAQVTATDADIGSNGEFYYYFKNKVD--LFSVHPTSGVISLSGRLNYDEKNRYD 228
PL T +A +T TD D NG + +++ L V ++ + L+Y+ Y
Sbjct: 406 IPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYA 465
Query: 229 LEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTI---HVVTHVPFSLEKEPTYAVV 285
+++LA D G ++ +A L++ ++ N++AP V +P + V
Sbjct: 466 IKLLAADAGKP-----PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKV 520
Query: 286 TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTL 345
+ D D G N EI ++ D +F L + L K +R++ D Y T+
Sbjct: 521 SATDADSGPNAEINY--LLGPDAPPEFSLDRRTGMLTVVKKLDREKED------KYLFTI 572
Query: 346 QAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPP-GVVVAIVKLSPEP 404
AKD G P S + D P+ F Y + E P G V I P+
Sbjct: 573 LAKDNGVPPLTSNVTVFVSIIDQNDNSPV-FTHNEYKFYVPENLPRHGTVGLITVTDPDY 631
Query: 405 IDVE-YKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG-----DLKAQV 458
D LS ++ F I+ ++G+I + K+E Y V ++G A+V
Sbjct: 632 GDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKV 691
Query: 459 TISIEDANDHTPEFQQPLYD---AYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN 515
TI++ D ND+ P F P Y+ V S GT V V A D D G N + YSI N
Sbjct: 692 TINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 751
Query: 516 LLP-FVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDN 574
F I+Q TG I+ E+ D + ++R +V+A+D G P S V V + + N
Sbjct: 752 TRDLFAIDQETGNITLMEKCDV-TDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTN 810
Query: 575 SPLFEKVACQGV 586
+ L ++ + +
Sbjct: 811 ATLINELVRKSI 822
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 273 bits (699), Expect = 2e-72
Identities = 199/653 (30%), Positives = 327/653 (50%), Gaps = 58/653 (8%)
Query: 718 INRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNID 777
IN P F + ++++ E+ + + A D D G NG + + + + F +D
Sbjct: 164 INDNAPLFPATV-INISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--KSQNIFGLD 220
Query: 778 M-------ETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPV 830
+ + QL V +DRE D Y++ + + D G PQ+SS +L ++V D NDN PV
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 280
Query: 831 FIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLT-----DTQQFAINSSTGI 885
F + V+I E++ +GT + Q+ A D D+G N ++ +S + F +N++TG+
Sbjct: 281 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 340
Query: 886 VYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAF------IPS 939
+ + + LDRE N+ L + A D G + + + V + DVND P+ P
Sbjct: 341 ITIKEPLDREETPNHKLLVLASD----GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 396
Query: 940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVR--------YSLVNDYNGRFEIDKASGA 991
+ +V + E++P+ T IA + D D G+V + L ++ +F ++ A+
Sbjct: 397 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-- 454
Query: 992 IRLSKELDYEKQQFYNLTVRAKDKGR-PVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVG 1050
LDYE + Y + + A D G+ P++ S++ F++V+ +EN + P F V
Sbjct: 455 -----YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK----DENDNAPVFTQSFVTV 505
Query: 1051 SVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRET 1110
S+ EN+ G +++V+A D DSG + EI Y + + FS+D +G++T LDRE
Sbjct: 506 SIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAP-PEFSLDRRTGMLTVVKKLDREK 564
Query: 1111 MGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI 1170
Y T+ A D GV PL S + V++ + D NDN+P+ + Y V EN P+ +V I
Sbjct: 565 EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLI 624
Query: 1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG 1230
DPD N +T I N F I+ +TG+I + DRE+Q + V DGG
Sbjct: 625 TVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVI-RPNISFDREKQESYTFYVKAEDGG 681
Query: 1231 PSPKQSTIWVVVQVLDENDNKPQF----PEKVYQIKLPERDRKKRGEPIYRAFAFDRDEG 1286
+ S+ V + V+D NDNKP F Y++ LP + G +++ A D D G
Sbjct: 682 RVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTN---PGTVVFQVIAVDNDTG 738
Query: 1287 PNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDI--LTIKAVDNGRP 1337
NAE+ YSIV GN F ID +TG ++ ++ + + +KA D G+P
Sbjct: 739 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791
Score = 259 bits (663), Expect = 3e-68
Identities = 200/697 (28%), Positives = 328/697 (47%), Gaps = 49/697 (7%)
Query: 2990 LDREEQDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIIL 3049
+ R+E Y + + + + D+NDN+P+ +PE+ N
Sbjct: 132 IPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYT 191
Query: 3050 KVSAKDADIGSNGYIRYSLYGSGNSEFFLD----PESGELKTLAL---LDRERIPVYSLM 3102
+A D D+G NG Y L S N F LD PE ++ L + LDRE Y +
Sbjct: 192 LPAAVDPDVGINGVQNYELIKSQNI-FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMK 250
Query: 3103 AKATDGGGRFCQSNIHLILE----DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDP 3158
K DGG F Q + IL+ D NDN PVF + EN +T++ A D
Sbjct: 251 VKVEDGG--FPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 308
Query: 3159 DIGINRKVVYSLADSAGGV----FSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQ 3214
DIG N K+ +S ++ + F +++++G+I +++PLDRE+ ++ + V A+D G
Sbjct: 309 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD---GG 365
Query: 3215 SLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSP-------GTQVLAVFATSKDIGT 3267
+ + V + V D+NDN P + R Y+V DT T++ + T KD
Sbjct: 366 LMPARAMVLVNVTDVNDNVPSIDIR-YIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424
Query: 3268 NAEITYLIRSGNEQGKFKINPKTGGISVSE---VLDYELCKRFYLVVEAKDGGTPALSAV 3324
N +T + + F++ P + E LDYE K + + + A D G P L+
Sbjct: 425 NGRVTCFT---DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQS 481
Query: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGD 3384
A + I + D NDN P F+Q + I E+ G ++ + A D DS PN +I++ ++ D
Sbjct: 482 AMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPD 540
Query: 3385 RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSP 3444
EF++D G++ V KKLDRE+ Y + A D+G+P ++S TV + I D NDNSP
Sbjct: 541 APPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSP 600
Query: 3445 VFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH-GIL 3503
VFT Y + EN P ++ + VTD D + + + SIL +E ++F +D G++
Sbjct: 601 VFTHNEYKFYVPENLPRHGTVGLITVTDPD-YGDNSAVTLSIL--DENDDFTIDSQTGVI 657
Query: 3504 RSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAI--PLEI-FIVT 3560
R + F + Y V+A+D G+ + S + + V++ + +KP I P + +
Sbjct: 658 RPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELV 717
Query: 3561 MEDDFPGGVIGKIHATDQDM---YDVLTFALKSEQKSLFKVNSHDGKIIAL---GGLDSG 3614
+ PG V+ ++ A D D +V + + LF ++ G I + D G
Sbjct: 718 LPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 777
Query: 3615 KYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTI 3651
+ + V +D + VV V V+E + N I
Sbjct: 778 LHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI 814
Score = 244 bits (624), Expect = 1e-63
Identities = 195/706 (27%), Positives = 332/706 (47%), Gaps = 47/706 (6%)
Query: 814 WRLLTIN--VEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL 871
+RL+ I +ED NDN+P+F +++I E+S I ++ A D D+G NG Y ++
Sbjct: 152 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 211
Query: 872 TDTQQFAIN-------SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKV 924
F ++ + V +LDRE K Y +K++ D Q S L+V
Sbjct: 212 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVED--GGFPQRSSTAILQV 269
Query: 925 FLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYS---LVNDYNG 981
+ D ND P F + V + E+ PVGT + L D D+G ++ +S LV++
Sbjct: 270 SVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 329
Query: 982 R-FEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHT 1040
R F ++ +G I + + LD E+ + L V A D G + + + V V V DVN+N+
Sbjct: 330 RLFHLNATTGLITIKEPLDREETPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNV-- 384
Query: 1041 PYFPDFAVVGSV------KENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
P +V V EN + T + +T D+D+ +G + +
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 444
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
++ A LD E+ Y + + A D G PL + ++I+V+D NDNAP+ ++
Sbjct: 445 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 504
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+ EN+ + ++++ A D DS N ++ Y + P F+++ +TG++T +KLDR
Sbjct: 505 VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE-FSLDRRTGMLTVV-KKLDR 562
Query: 1215 EQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEP 1274
E++ ++ + D G P S + V V ++D+NDN P F Y+ +PE R
Sbjct: 563 EKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE--NLPRHGT 620
Query: 1275 IYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILT--IKAV 1332
+ D D G N+ ++ SI+D NDD F ID +TG++ F + T +KA
Sbjct: 621 VGLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAE 678
Query: 1333 DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFT---VMESDR----VTEIVGVVS 1385
D GR +SS+A++ I + P+ F P YN++ V+ S V +++ V +
Sbjct: 679 DGGRVSRSSSAKVTINVVDVNDNKPV---FIVPPYNYSYELVLPSTNPGTVVFQVIAVDN 735
Query: 1386 VQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD-GTNVAVT 1444
N + + IVGGN F ++ G I + + D ++ + V+ D G ++
Sbjct: 736 DTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 795
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDV--TISEDVLPDTEILQIEATDRD 1488
V I L N++ + N V +I V P+TEI + + D
Sbjct: 796 SVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841
Score = 226 bits (576), Expect = 4e-58
Identities = 189/668 (28%), Positives = 316/668 (47%), Gaps = 46/668 (6%)
Query: 915 QLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYS 974
++F +V ++ ++D+ND +P F + ++ + E+ + + DPD+G+ G Y
Sbjct: 150 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 209
Query: 975 LVNDYN--GRFEIDKASG----AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVE 1028
L+ N G I+ G + + KELD E++ Y + V+ +D G P SS + ++
Sbjct: 210 LIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQ 268
Query: 1029 VEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD-GSG 1087
V V D N+N P F + + S+ EN+ +GTSV Q+ A D D G + +I +S + S
Sbjct: 269 VSVTDTNDN--HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 326
Query: 1088 LGR--FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1145
+ R F ++ +G+IT + LDRE ++ L V A+D G++P + V + V DVNDN
Sbjct: 327 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNV 384
Query: 1146 PLTS-----EPIYYPVVM-ENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAIN 1199
P P+ VV+ EN P + + I D D+ N ++T P +
Sbjct: 385 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPV- 443
Query: 1200 IKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVY 1259
+ + LD E E+ +++ D G P + + ++V DENDN P F +
Sbjct: 444 FSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503
Query: 1260 QIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF 1319
+ +PE + G + + A D D GPNAEI+Y ++ + +F +D +TGM++ K+
Sbjct: 504 TVSIPENN--SPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKL 560
Query: 1320 TAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV 1377
D + TI A DNG P +S + + I + SP+ F Y F V E+
Sbjct: 561 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPV---FTHNEYKFYVPENLPR 617
Query: 1378 TEIVGVVSVQPA----NTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSV 1433
VG+++V N+ + I+ N D D++ GV I+ D E++ Y V
Sbjct: 618 HGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNIS--FDREKQESYTFYV 675
Query: 1434 EVTDGTNV---AVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTE----ILQIEATD 1486
+ DG V + +V I V+D NDN P F P Y+ + E VLP T + Q+ A D
Sbjct: 676 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSY-ELVLPSTNPGTVVFQVIAVD 734
Query: 1487 RDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYR 1546
D +S + + F ID TG + E+ D D + ++V+ +
Sbjct: 735 NDTGMNAEVR-YSIVGGNTRDLFAIDQETGNITLMEKCD--VTDLGLHRVLVKANDLGQP 791
Query: 1547 RNLARVIV 1554
+L V++
Sbjct: 792 DSLFSVVI 799
Score = 216 bits (549), Expect = 5e-55
Identities = 185/699 (26%), Positives = 311/699 (44%), Gaps = 37/699 (5%)
Query: 2271 VTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDT 2330
V + L+ D+NDN P+F N ++ E S I + ++D D N + +Y++++
Sbjct: 155 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-- 212
Query: 2331 YNSTDYFHID-------SSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIY 2383
S + F +D ++ + LD E +KV+ D GFP SS ++ +
Sbjct: 213 --SQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 270
Query: 2384 ISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYS---ILSGNDRT 2440
++D NDN PVF + E + E AP G VT + A+DAD + ++ +S ++S R
Sbjct: 271 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 2441 SFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG-LFTSTAQVHIRVLGANLYSPAFSQS 2499
F +++ +G+IT+ + P + L V SDG L + A V + V N P+
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 390
Query: 2500 TYVAEVR------ENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVI 2553
V V EN+ TK+ + TD D G+++ ++ + SN ++
Sbjct: 391 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 450
Query: 2554 TTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRAD 2612
LD E+ E + + + + V DENDNAP F S+ +
Sbjct: 451 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 510
Query: 2613 VGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNT 2672
G + +V A D D G N+ I Y L +A + +D G + ++ K
Sbjct: 511 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFS----LDRRTGMLTVVKKLDREKED 566
Query: 2673 VLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRI 2732
F + A D G+P S + V++ ++ P FT ++Y F + E+ TV + +
Sbjct: 567 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITV 626
Query: 2733 LPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKV 2792
S V + N F I+ +TG I+ + DRE ++ F V A +V
Sbjct: 627 TDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDG-GRV 683
Query: 2793 DIVFTVDVDIKVLDLNDNKPVFETSSYD---TIIMEGMPVGTKLTQVRAIDMDWGANGQV 2849
+ V I V+D+NDNKPVF Y+ +++ GT + QV A+D D G N +V
Sbjct: 684 SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEV 743
Query: 2850 TYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTAL 2909
YS+ + + F ID TG I+ ++ D V A+DLG+ SL S +
Sbjct: 744 RYSIVGGN----TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 799
Query: 2910 VSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLST 2948
V++ V + NA + E+ R +++ P +A +S+
Sbjct: 800 VNLFVNESVTNATLI-NELVRKSIEAPVTPNTEIADVSS 837
Score = 215 bits (548), Expect = 7e-55
Identities = 189/663 (28%), Positives = 304/663 (45%), Gaps = 74/663 (11%)
Query: 429 IVTARPLNTVKKEVYKLEVTNKEGDLK-----AQVTISIEDANDHTPEFQQPLYDAYVNE 483
++ + L+ +K+ Y ++V ++G A + +S+ D ND+ P F++ + + E
Sbjct: 233 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 292
Query: 484 SVPVGTSVLTVSASDKDKGENGYITYSIASL--NLLP--FVINQFTGVISTTEELDFESS 539
+ PVGTSV + A+D D GEN I +S ++L N+ F +N TG+I+ E LD E +
Sbjct: 293 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 352
Query: 540 PEIYRFIVRASDWG-SPYRHESEVNVTIRIGNVNDNSP------LFEKVACQGVISYDFP 592
P ++ +V ASD G P R VNVT +VNDN P + V V+S + P
Sbjct: 353 PN-HKLLVLASDGGLMPARAMVLVNVT----DVNDNVPSIDIRYIVNPVNDTVVLSENIP 407
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ I ++ D D + + +E+ F S L+ + +A++
Sbjct: 408 LNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 467
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ A D A +N S + L IK K
Sbjct: 468 LLAAD----AGKPPLNQSAM-----------------------LFIKVKDE--------- 491
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
N P F +SF + V++ E+ G ++K+ A DADSG N ++ + +
Sbjct: 492 ------NDNAPVFTQSFVT-VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE 544
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFI 832
F++D TG L V+ +DRE D YL I D G P +S + +++ D NDNSPVF
Sbjct: 545 -FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 603
Query: 833 QDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQL 892
+ Y + E+ + + D D G N VT S+L + F I+S TG++
Sbjct: 604 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 893 DRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI--PSSYSVK-VLEDL 949
DRE + +Y+ ++A D + + VT+ V DVND P FI P +YS + VL
Sbjct: 664 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVV--DVNDNKPVFIVPPYNYSYELVLPST 721
Query: 950 PVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNL 1008
GTV+ + D D G+ +VRYS+V + F ID+ +G I L ++ D + +
Sbjct: 722 NPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRV 781
Query: 1009 TVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAR 1068
V+A D G+P SL SV V + VNE++ + V S++ T + V++
Sbjct: 782 LVKANDLGQPDSLFSVVIVN---LFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSP 838
Query: 1069 DED 1071
D
Sbjct: 839 TSD 841
Score = 214 bits (544), Expect = 2e-54
Identities = 218/804 (27%), Positives = 351/804 (43%), Gaps = 68/804 (8%)
Query: 1150 EPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS 1209
E I V++ N KD+++ I + ++ KL Y+ T P I TG I TT
Sbjct: 64 EEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYK-TGDVP--LIRIEEDTGEIFTTG 120
Query: 1210 RKLDREQ------QAEH-FLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIK 1262
++DRE+ + EH F EV V P + + + D NDN P FP V I
Sbjct: 121 ARIDREKLCAGIPRDEHCFYEVEVAIL-PDEIFRLVKIRFLIEDINDNAPLFPATVINIS 179
Query: 1263 LPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDG-NDDGKFFIDPKTG----MVSSRK 1317
+PE + A D D G N +Y ++ N G I+ G + +K
Sbjct: 180 IPENSAINSKYTL--PAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQK 237
Query: 1318 QFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESD 1375
+ D ++ +K D G PQ+SSTA L + P+ F E ++ E+
Sbjct: 238 ELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV---FKETEIEVSIPENA 294
Query: 1376 RVTEIVGVVSVQPA----NTPLWF---DIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSI 1428
V V + A N + F ++V F G I I +PLD E+
Sbjct: 295 PVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN 354
Query: 1429 YNMSVEVTDGTNV-AVTQVFIKVLDNNDNGPEF------SQPNYDVTISEDVLPDTEILQ 1481
+ + V +DG + A V + V D NDN P + N V +SE++ +T+I
Sbjct: 355 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 414
Query: 1482 IEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 1541
I TD+D H T + + I R + + +L A LD+E+ ++ + ++ D
Sbjct: 415 ITVTDKDADHNGRVTCFTDHE-IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADA 473
Query: 1542 EFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAEL 1601
P A + + V+D ND++P FT S+ E+ + G +++V+A D D G NAE+
Sbjct: 474 GKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEI 533
Query: 1602 IYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661
Y + + F ++ G++T+ K+ D +++ +I D G PP+++ V +S+
Sbjct: 534 NYLL-GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 592
Query: 1662 TMSDNSHPKFIHKDYQAEVNENVDIGTSVILI----------SAISQSTLIYEVKDGDIN 1711
+++ P F H +Y+ V EN+ +V LI SA++ S L D N
Sbjct: 593 IDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL-------DEN 645
Query: 1712 GIFTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDENDNAPVF 1769
FTI+ +GVI + D E+ SY ++A + +S+A V I +VD NDN PVF
Sbjct: 646 DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF 705
Query: 1770 LFSQYSGSLSEAAPINSIVRSLDNSPLVIR--ATDADSNRNALLVYQIVESTAKKFFTVD 1827
+ Y+ S P S + +V + A D D+ NA + Y IV + F +D
Sbjct: 706 IVPPYNYSYELVLP------STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAID 759
Query: 1828 SSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAV 1887
TG I + D + V D G P + S V VN+ V + N + + V
Sbjct: 760 QETGNITLMEKCDVTDLGLHRVLVKANDLGQPD-SLFSVVIVNLFVNESVTNATLINELV 818
Query: 1888 FETILLLPTYVGVEVLKVSATDPD 1911
++I P E+ VS+ D
Sbjct: 819 RKSI-EAPVTPNTEIADVSSPTSD 841
Score = 205 bits (521), Expect = 1e-51
Identities = 198/700 (28%), Positives = 315/700 (45%), Gaps = 56/700 (8%)
Query: 2027 KIKSTSGVIQTTGVPFDRE---------EQELYELVVEASRELDHLRVARVV-VRVNIED 2076
+I+ +G I TTG DRE E YE+ V + + R+V +R IED
Sbjct: 108 RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD----EIFRLVKIRFLIED 163
Query: 2077 INDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL---QDDYGHFEIN 2133
INDN+P+F ++ ++ + A+D D G NG Y L Q+ +G I
Sbjct: 164 INDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIE 223
Query: 2134 PNSGNVILKEAFNSDLSNIE---YGVTILAKDGGKPSLSTS--VELPITIVNKAMPVFDK 2188
G+ + + +L E Y + + +DGG P S++ +++ +T N PVF +
Sbjct: 224 TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKE 283
Query: 2189 PFYTASVNEDIRMNTPILSINATSPE-GQGI-----IYIIIDGDPFKQFNIDFDTGVLKV 2242
S+ E+ + T + ++AT + G+ ++ + F+++ TG++ +
Sbjct: 284 TEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITI 343
Query: 2243 VSPLDYEVTSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFD-----QPTYNT-T 2295
PLD E T +KL + ASD L ARA V V+ V DVNDN P D P +T
Sbjct: 344 KEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVV 401
Query: 2296 LSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHE 2355
LSE + T + + D D+++N V D + S+ L+ A LD+E
Sbjct: 402 LSENIPLNTKIALITVTDKDADHNGRV--TCFTDHEIPFRLRPVFSNQFLLENAAYLDYE 459
Query: 2356 LVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTC 2415
+ +K+ + D+G P L+ ++ I + D NDN PVF Q + E G +
Sbjct: 460 STKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMK 519
Query: 2416 VQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG- 2474
V A+DADS + Y +L + F +D ++G++T+ + E Y + D
Sbjct: 520 VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNG 578
Query: 2475 --LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQIS 2532
TS V + ++ N SP F+ + Y V EN+ V + TD D G ++
Sbjct: 579 VPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVT 638
Query: 2533 YAIINDFAKDRFLIDSNGQVITTE-RLDRENPLEGDVSIFVRALDGG--GRTTFCTVRVI 2589
+I+++ D F IDS VI DRE + + +V+A DGG R++ V +
Sbjct: 639 LSILDE--NDDFTIDSQTGVIRPNISFDREK--QESYTFYVKAEDGGRVSRSSSAKVTIN 694
Query: 2590 VVDENDNAPQFMTVEYRAS---VRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVS 2646
VVD NDN P F+ Y S V G +V QV A+D D G N+ + YS+ +
Sbjct: 695 VVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI---VGGN 751
Query: 2647 VADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIP 2686
DL ID + G + + + VKA D G P
Sbjct: 752 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791
Score = 202 bits (514), Expect = 6e-51
Identities = 182/698 (26%), Positives = 309/698 (44%), Gaps = 46/698 (6%)
Query: 1951 YMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNR 2010
Y + V + + + + ++++ D+ F + + SI EN+ +K + AV
Sbjct: 140 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 199
Query: 2011 --LNEPLKYSILNPGNKFKI---------KSTSGVIQTTGVPFDREEQELYELVVEASRE 2059
+N Y ++ N F + K ++Q DREE++ Y + V+
Sbjct: 200 VGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE---LDREEKDTYVMKVKVEDG 256
Query: 2060 LDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEV 2119
R + +++V++ D NDN PVF ++ +A GT + Q+ A D D G N ++
Sbjct: 257 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 316
Query: 2120 TYVLQDDYGH-----FEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVEL 2174
+ + + F +N +G + +KE + + + + +LA DGG V +
Sbjct: 317 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDRE-ETPNHKLLVLASDGGLMPARAMVLV 375
Query: 2175 PITIVNKAMPVFDKPFYTASVN------EDIRMNTPILSINATSPEGQ--GIIYIIIDGD 2226
+T VN +P D + VN E+I +NT I I T + G + D +
Sbjct: 376 NVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHE 435
Query: 2227 -PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDA-LTGARAEVTVDLLVNDVNDNP 2284
PF+ + + +L+ + LDYE T Y + + A+DA + + V D NDN
Sbjct: 436 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495
Query: 2285 PIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSG 2344
P+F Q ++ E + G +++V + DADS N ++Y + D + F +D +G
Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPD---APPEFSLDRRTG 552
Query: 2345 LILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVS 2404
++ + LD E + + D+G P L+S V V + I D NDN PVF Y+ YV
Sbjct: 553 MLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVP 612
Query: 2405 ELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPL 2464
E PR V + +D D D + SIL ND F +DS++GVI + + +
Sbjct: 613 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQES 670
Query: 2465 YSLNVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTY---VAEVRENVAAGTKVIHV 2518
Y+ V DG +S+A+V I V+ N P F Y V + GT V V
Sbjct: 671 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730
Query: 2519 RATDGDPGTYGQISYAIINDFAKDRFLID-SNGQVITTERLDRENPLEGDVSIFVRALDG 2577
A D D G ++ Y+I+ +D F ID G + E+ D + G + V+A D
Sbjct: 731 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTD--LGLHRVLVKANDL 788
Query: 2578 GGRTTFCTVRVIVVDENDNAPQFMTVE--YRASVRADV 2613
G + +V ++ + N++ + R S+ A V
Sbjct: 789 GQPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826
Score = 195 bits (496), Expect = 8e-49
Identities = 190/680 (27%), Positives = 299/680 (43%), Gaps = 65/680 (9%)
Query: 2465 YSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGD 2524
Y + V++ ++ + N +P F + + EN A +K A D D
Sbjct: 140 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 199
Query: 2525 PGTYGQISYAII---NDFAKDRFLI---DSNGQVITTERLDRENPLEGDVSIFVRALDGG 2578
G G +Y +I N F D D Q+I + LDRE E D + ++ G
Sbjct: 200 VGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE---EKDTYVMKVKVEDG 256
Query: 2579 G---RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRI 2635
G R++ ++V V D NDN P F E S+ + G VTQ+ A D D G N++I
Sbjct: 257 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 316
Query: 2636 TYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVY 2695
+S + S L ++ G + K ++ + V A DGG+ ++ V
Sbjct: 317 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VL 374
Query: 2696 IHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGI 2755
++V +PS +Y DT + S I + + TV + ++N
Sbjct: 375 VNVTDVNDNVPSI-DIRYIVNPVNDTVVLSE----NIPLNTKIALITVTDKDADHNGRVT 429
Query: 2756 FVIEQE---------TGTIKLDKR--LDRETSPAFHFKV----AATIPLDKVDIVFTVDV 2800
+ E + L+ LD E++ + K+ A PL++ ++F
Sbjct: 430 CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF---- 485
Query: 2801 DIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPE 2860
IKV D NDN PVF S I E G +L +V A D D G N ++ Y L D+ PE
Sbjct: 486 -IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE 544
Query: 2861 KVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDN 2920
F++D TG ++ +K LD E + + F+++A D G L+S V V + D NDN
Sbjct: 545 -----FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDN 598
Query: 2921 APVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQS 2980
+PVF Y+ V E+ P V +++ D D D N V+ I N F +
Sbjct: 599 SPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSILDEN--DDFTI----- 650
Query: 2981 EWKVYVKRP---LDREEQDIYFLNITATDGLFVTQ---AMVEVSVSDVNDNSPVC----D 3030
+ + V RP DRE+Q+ Y + A DG V++ A V ++V DVNDN PV
Sbjct: 651 DSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPY 710
Query: 3031 QVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLA 3089
+Y +LP P ++ +V A D D G N +RYS+ G + F +D E+G + +
Sbjct: 711 NYSYELVLPSTNPGT-VVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLME 769
Query: 3090 LLDRERIPVYSLMAKATDGG 3109
D + ++ ++ KA D G
Sbjct: 770 KCDVTDLGLHRVLVKANDLG 789
Score = 180 bits (457), Expect = 3e-44
Identities = 188/676 (27%), Positives = 317/676 (46%), Gaps = 66/676 (9%)
Query: 1424 EQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIE 1483
++ Y + V + + ++ + D NDN P F +++I E+ +++
Sbjct: 135 DEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPA 194
Query: 1484 ATDRD------EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIM 1537
A D D + ++L + +I + + + L + LD E +D +++ +
Sbjct: 195 AVDPDVGINGVQNYELIKS--QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 252
Query: 1538 VRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGE 1597
V D FP R + A + V+V D ND+ P F E S+ E+A +G++V Q+ A D D GE
Sbjct: 253 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 312
Query: 1598 NAELIYT---IEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSAT 1654
NA++ ++ + + +F + G+ITI + D L + +D G P A
Sbjct: 313 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--AR 370
Query: 1655 AIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDGDING-- 1712
A+V ++VT +++ P + VN+ V + ++ L + I+ T+ KD D NG
Sbjct: 371 AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV--TDKDADHNGRV 428
Query: 1713 --------IFTINP-YSGVITTQKA--LDYERTSSYQLIIQATNMA--GMASNATVNIQI 1759
F + P +S + A LDYE T Y + + A + + +A + I++
Sbjct: 429 TCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKV 488
Query: 1760 VDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSP----LVIRATDADSNRNALLVYQI 1815
DENDNAPVF S + S+ E +NSP + + ATDADS NA + Y +
Sbjct: 489 KDENDNAPVFTQSFVTVSIPE-----------NNSPGIQLMKVSATDADSGPNAEINY-L 536
Query: 1816 VESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTD 1875
+ A F++D TG + + LD E + F + +D+G P LT S V V + + D
Sbjct: 537 LGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLT--SNVTVFVSIID 594
Query: 1876 VNDNPPVFTQAVFETIL--LLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLID 1933
NDN PVFT ++ + LP + V ++ V TDPD +T S+++ + D F ID
Sbjct: 595 QNDNSPVFTHNEYKFYVPENLPRHGTVGLITV--TDPDYGDNSAVTLSILDEN-DDFTID 651
Query: 1934 SNSGVL--TIKNNNLSKDHYMLIVKVSDG---KFYSTSMVTIMVKEAMDSGLHFTQSFYS 1988
S +GV+ I + ++ Y VK DG S++ VTI V + D+ F Y+
Sbjct: 652 SQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYN 711
Query: 1989 TS---ISENNTNITKVAIVNAVGN--RLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVP 2041
S + + T V V AV N +N ++YSI+ N + F I +G I T
Sbjct: 712 YSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI-TLMEK 770
Query: 2042 FDREEQELYELVVEAS 2057
D + L+ ++V+A+
Sbjct: 771 CDVTDLGLHRVLVKAN 786
Score = 177 bits (449), Expect = 2e-43
Identities = 163/563 (28%), Positives = 264/563 (46%), Gaps = 58/563 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKV-NIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
L+RE +D Y++ VK G + T + + V D ND P+F T V+I E+ P+ T
Sbjct: 239 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 298
Query: 176 SVAQVTATDADIGSNGEFYYYFKNKVD-----LFSVHPTSGVISLSGRLNYDEKNRYDLE 230
SV Q+ ATDADIG N + ++ F N V LF ++ T+G+I++ L+ +E + L
Sbjct: 299 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 358
Query: 231 ILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHV------VTHVPFSLEKEP---T 281
+LA D G+ + + A + V++ +N++ P+I + V E P
Sbjct: 359 VLASDGGL-------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 411
Query: 282 YAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGY 341
A++TV D D NG + + D F L + N++ ++ +D+ES Y
Sbjct: 412 IALITVTDKDADHNGRVTCFT----DHEIPFRL--RPVFSNQFLLENAAYLDYES-TKEY 464
Query: 342 NLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLS 401
+ L A D G P + D P+ F + VSI E + PG + ++K+S
Sbjct: 465 AIKLLAADAGKPPLNQSAMLFIKVKDENDNAPV-FTQSFVTVSIPENNSPG--IQLMKVS 521
Query: 402 PEPID------VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDL- 454
D + Y L P + F ++ R+G++ + L+ K++ Y + K+ +
Sbjct: 522 ATDADSGPNAEINYLLGP-DAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 580
Query: 455 ----KAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYS 510
V +SI D ND++P F Y YV E++P +V ++ +D D G+N +T S
Sbjct: 581 PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 640
Query: 511 IASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGN 570
I N F I+ TGVI D E E Y F V+A D G R S VTI + +
Sbjct: 641 ILDEN-DDFTIDSQTGVIRPNISFDREKQ-ESYTFYVKAEDGGRVSR-SSSAKVTINVVD 697
Query: 571 VNDNSPLFEKVACQGVISYDFPV-----GGHITAVSAIDIDE--LELVKYKIISGNELGF 623
VNDN P+F + SY+ + G + V A+D D V+Y I+ GN
Sbjct: 698 VNDNKPVF--IVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL 755
Query: 624 FYLNPDSGVLQL--KKSLTNSGI 644
F ++ ++G + L K +T+ G+
Sbjct: 756 FAIDQETGNITLMEKCDVTDLGL 778
Score = 135 bits (341), Expect = 7e-31
Identities = 170/722 (23%), Positives = 305/722 (42%), Gaps = 90/722 (12%)
Query: 129 VKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIG 188
V+ ++ +++ K+ + D+ND PLF T +++I E++ + + A D D+G
Sbjct: 142 VEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVG 201
Query: 189 SNGEFYYYFKNKVDLFS---VHPTSG----VISLSGRLNYDEKNRYDLEILAVDRGMKLY 241
NG Y ++F + G + + L+ +EK+ Y +++ D G
Sbjct: 202 INGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR 261
Query: 242 GNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSL-EKEPTYAVVT---VDDLDDGANGE 297
SSTA L V + N++ P + T + S+ E P VT D D G N +
Sbjct: 262 -----SSTAILQVSVTDTNDNHP-VFKETEIEVSIPENAPVGTSVTQLHATDADIGENAK 315
Query: 298 IE-SVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKG-SPQK 355
I S S + + + F L I ++ +D E P + L + A D G P +
Sbjct: 316 IHFSFSNLVSNIARRLFHLNATTGL----ITIKEPLDREETP-NHKLLVLASDGGLMPAR 370
Query: 356 CSALKAVYIGNPTRDTVPIRF-EKEVYD-VSISEFSPPGVVVAIVKLSPEPIDVEYKLSP 413
L V N ++ IR+ V D V +SE P +A++ ++ + D +++
Sbjct: 371 AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC 430
Query: 414 GED-AVYFKINP---RSGLIVTARPLNTVKKEVYKLEVTNKEG-----DLKAQVTISIED 464
D + F++ P L+ A L+ + Y +++ + + A + I ++D
Sbjct: 431 FTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKD 490
Query: 465 ANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQF 524
ND+ P F Q + E+ G ++ VSA+D D G N I Y + F +++
Sbjct: 491 ENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRR 550
Query: 525 TGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
TG+++ ++LD E + Y F + A D G P S V V + I + NDNSP+F +
Sbjct: 551 TGMLTVVKKLDREKEDK-YLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYK 608
Query: 585 GVISYDFPVGGHITAVSAIDID--ELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNS 642
+ + P G + ++ D D + V I+ N+ F ++ +GV++ S
Sbjct: 609 FYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDRE 666
Query: 643 GIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKA 702
K ++ + A DG G+VS S A
Sbjct: 667 --KQESYTFYVKAEDG---------------GRVSRSS--------------------SA 689
Query: 703 NGKLNLEDGFLDFYSINRQGPYF---DKSFPSDVAVKEDLPVGANILKIKAYDADSGFNG 759
+N+ D +N P F ++ ++ + P G + ++ A D D+G N
Sbjct: 690 KVTINVVD-------VNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNA 741
Query: 760 KVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTI 819
+V ++I GNT F ID ETG + ++ D L+ + + DLG P S + ++ +
Sbjct: 742 EVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD-SLFSVVIV 800
Query: 820 NV 821
N+
Sbjct: 801 NL 802
Score = 126 bits (316), Expect = 6e-28
Identities = 133/492 (27%), Positives = 216/492 (43%), Gaps = 38/492 (7%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMND------LRPLFSPTTYSVTIAES 170
L+RE N+ L+V S G + A V + V D+ND +R + +P +V ++E+
Sbjct: 347 LDREETPNHKLLVLASDGGL-MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSEN 405
Query: 171 TPLRTSVAQVTATDADIGSNGEFYYYFKNKVD--LFSVHPTSGVISLSGRLNYDEKNRYD 228
PL T +A +T TD D NG + +++ L V ++ + L+Y+ Y
Sbjct: 406 IPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYA 465
Query: 229 LEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTI---HVVTHVPFSLEKEPTYAVV 285
+++LA D G ++ +A L++ ++ N++AP V +P + V
Sbjct: 466 IKLLAADAGKP-----PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKV 520
Query: 286 TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTL 345
+ D D G N EI ++ D +F L + L K +R++ D Y T+
Sbjct: 521 SATDADSGPNAEINY--LLGPDAPPEFSLDRRTGMLTVVKKLDREKED------KYLFTI 572
Query: 346 QAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPP-GVVVAIVKLSPEP 404
AKD G P S + D P+ F Y + E P G V I P+
Sbjct: 573 LAKDNGVPPLTSNVTVFVSIIDQNDNSPV-FTHNEYKFYVPENLPRHGTVGLITVTDPDY 631
Query: 405 IDVE-YKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG-----DLKAQV 458
D LS ++ F I+ ++G+I + K+E Y V ++G A+V
Sbjct: 632 GDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKV 691
Query: 459 TISIEDANDHTPEFQQPLYD---AYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN 515
TI++ D ND+ P F P Y+ V S GT V V A D D G N + YSI N
Sbjct: 692 TINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 751
Query: 516 LLP-FVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDN 574
F I+Q TG I+ E+ D + ++R +V+A+D G P S V V + + N
Sbjct: 752 TRDLFAIDQETGNITLMEKCDV-TDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTN 810
Query: 575 SPLFEKVACQGV 586
+ L ++ + +
Sbjct: 811 ATLINELVRKSI 822
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 273 bits (699), Expect = 2e-72
Identities = 199/653 (30%), Positives = 327/653 (50%), Gaps = 58/653 (8%)
Query: 718 INRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNID 777
IN P F + ++++ E+ + + A D D G NG + + + + F +D
Sbjct: 153 INDNAPLFPATV-INISIPENSAINSKYTLPAAVDPDVGINGVQNYELI--KSQNIFGLD 209
Query: 778 M-------ETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPV 830
+ + QL V +DRE D Y++ + + D G PQ+SS +L ++V D NDN PV
Sbjct: 210 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 269
Query: 831 FIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLT-----DTQQFAINSSTGI 885
F + V+I E++ +GT + Q+ A D D+G N ++ +S + F +N++TG+
Sbjct: 270 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 329
Query: 886 VYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAF------IPS 939
+ + + LDRE N+ L + A D G + + + V + DVND P+ P
Sbjct: 330 ITIKEPLDREETPNHKLLVLASD----GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPV 385
Query: 940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVR--------YSLVNDYNGRFEIDKASGA 991
+ +V + E++P+ T IA + D D G+V + L ++ +F ++ A+
Sbjct: 386 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-- 443
Query: 992 IRLSKELDYEKQQFYNLTVRAKDKGR-PVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVG 1050
LDYE + Y + + A D G+ P++ S++ F++V+ +EN + P F V
Sbjct: 444 -----YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK----DENDNAPVFTQSFVTV 494
Query: 1051 SVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRET 1110
S+ EN+ G +++V+A D DSG + EI Y + + FS+D +G++T LDRE
Sbjct: 495 SIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAP-PEFSLDRRTGMLTVVKKLDREK 553
Query: 1111 MGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQI 1170
Y T+ A D GV PL S + V++ + D NDN+P+ + Y V EN P+ +V I
Sbjct: 554 EDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLI 613
Query: 1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGG 1230
DPD N +T I N F I+ +TG+I + DRE+Q + V DGG
Sbjct: 614 TVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVI-RPNISFDREKQESYTFYVKAEDGG 670
Query: 1231 PSPKQSTIWVVVQVLDENDNKPQF----PEKVYQIKLPERDRKKRGEPIYRAFAFDRDEG 1286
+ S+ V + V+D NDNKP F Y++ LP + G +++ A D D G
Sbjct: 671 RVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTN---PGTVVFQVIAVDNDTG 727
Query: 1287 PNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDI--LTIKAVDNGRP 1337
NAE+ YSIV GN F ID +TG ++ ++ + + +KA D G+P
Sbjct: 728 MNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 780
Score = 259 bits (663), Expect = 3e-68
Identities = 200/697 (28%), Positives = 328/697 (47%), Gaps = 49/697 (7%)
Query: 2990 LDREEQDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIIL 3049
+ R+E Y + + + + D+NDN+P+ +PE+ N
Sbjct: 121 IPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYT 180
Query: 3050 KVSAKDADIGSNGYIRYSLYGSGNSEFFLD----PESGELKTLAL---LDRERIPVYSLM 3102
+A D D+G NG Y L S N F LD PE ++ L + LDRE Y +
Sbjct: 181 LPAAVDPDVGINGVQNYELIKSQNI-FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMK 239
Query: 3103 AKATDGGGRFCQSNIHLILE----DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDP 3158
K DGG F Q + IL+ D NDN PVF + EN +T++ A D
Sbjct: 240 VKVEDGG--FPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 297
Query: 3159 DIGINRKVVYSLADSAGGV----FSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQ 3214
DIG N K+ +S ++ + F +++++G+I +++PLDRE+ ++ + V A+D G
Sbjct: 298 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD---GG 354
Query: 3215 SLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSP-------GTQVLAVFATSKDIGT 3267
+ + V + V D+NDN P + R Y+V DT T++ + T KD
Sbjct: 355 LMPARAMVLVNVTDVNDNVPSIDIR-YIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 413
Query: 3268 NAEITYLIRSGNEQGKFKINPKTGGISVSE---VLDYELCKRFYLVVEAKDGGTPALSAV 3324
N +T + + F++ P + E LDYE K + + + A D G P L+
Sbjct: 414 NGRVTCFT---DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQS 470
Query: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGD 3384
A + I + D NDN P F+Q + I E+ G ++ + A D DS PN +I++ ++ D
Sbjct: 471 AMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPD 529
Query: 3385 RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSP 3444
EF++D G++ V KKLDRE+ Y + A D+G+P ++S TV + I D NDNSP
Sbjct: 530 APPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSP 589
Query: 3445 VFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH-GIL 3503
VFT Y + EN P ++ + VTD D + + + SIL +E ++F +D G++
Sbjct: 590 VFTHNEYKFYVPENLPRHGTVGLITVTDPD-YGDNSAVTLSIL--DENDDFTIDSQTGVI 646
Query: 3504 RSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAI--PLEI-FIVT 3560
R + F + Y V+A+D G+ + S + + V++ + +KP I P + +
Sbjct: 647 RPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELV 706
Query: 3561 MEDDFPGGVIGKIHATDQDM---YDVLTFALKSEQKSLFKVNSHDGKIIAL---GGLDSG 3614
+ PG V+ ++ A D D +V + + LF ++ G I + D G
Sbjct: 707 LPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 766
Query: 3615 KYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTI 3651
+ + V +D + VV V V+E + N I
Sbjct: 767 LHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI 803
Score = 244 bits (624), Expect = 1e-63
Identities = 195/706 (27%), Positives = 332/706 (47%), Gaps = 47/706 (6%)
Query: 814 WRLLTIN--VEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL 871
+RL+ I +ED NDN+P+F +++I E+S I ++ A D D+G NG Y ++
Sbjct: 141 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELI 200
Query: 872 TDTQQFAIN-------SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKV 924
F ++ + V +LDRE K Y +K++ D Q S L+V
Sbjct: 201 KSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVED--GGFPQRSSTAILQV 258
Query: 925 FLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYS---LVNDYNG 981
+ D ND P F + V + E+ PVGT + L D D+G ++ +S LV++
Sbjct: 259 SVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIAR 318
Query: 982 R-FEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHT 1040
R F ++ +G I + + LD E+ + L V A D G + + + V V V DVN+N+
Sbjct: 319 RLFHLNATTGLITIKEPLDREETPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNV-- 373
Query: 1041 PYFPDFAVVGSV------KENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
P +V V EN + T + +T D+D+ +G + +
Sbjct: 374 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF 433
Query: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
++ A LD E+ Y + + A D G PL + ++I+V+D NDNAP+ ++
Sbjct: 434 SNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVT 493
Query: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
+ EN+ + ++++ A D DS N ++ Y + P F+++ +TG++T +KLDR
Sbjct: 494 VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE-FSLDRRTGMLTVV-KKLDR 551
Query: 1215 EQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEP 1274
E++ ++ + D G P S + V V ++D+NDN P F Y+ +PE R
Sbjct: 552 EKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE--NLPRHGT 609
Query: 1275 IYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILT--IKAV 1332
+ D D G N+ ++ SI+D NDD F ID +TG++ F + T +KA
Sbjct: 610 VGLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAE 667
Query: 1333 DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFT---VMESDR----VTEIVGVVS 1385
D GR +SS+A++ I + P+ F P YN++ V+ S V +++ V +
Sbjct: 668 DGGRVSRSSSAKVTINVVDVNDNKPV---FIVPPYNYSYELVLPSTNPGTVVFQVIAVDN 724
Query: 1386 VQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD-GTNVAVT 1444
N + + IVGGN F ++ G I + + D ++ + V+ D G ++
Sbjct: 725 DTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLF 784
Query: 1445 QVFIKVLDNNDNGPEFSQPNYDV--TISEDVLPDTEILQIEATDRD 1488
V I L N++ + N V +I V P+TEI + + D
Sbjct: 785 SVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 830
Score = 226 bits (576), Expect = 4e-58
Identities = 189/668 (28%), Positives = 316/668 (47%), Gaps = 46/668 (6%)
Query: 915 QLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYS 974
++F +V ++ ++D+ND +P F + ++ + E+ + + DPD+G+ G Y
Sbjct: 139 EIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE 198
Query: 975 LVNDYN--GRFEIDKASG----AIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVE 1028
L+ N G I+ G + + KELD E++ Y + V+ +D G P SS + ++
Sbjct: 199 LIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP-QRSSTAILQ 257
Query: 1029 VEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD-GSG 1087
V V D N+N P F + + S+ EN+ +GTSV Q+ A D D G + +I +S + S
Sbjct: 258 VSVTDTNDN--HPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN 315
Query: 1088 LGR--FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1145
+ R F ++ +G+IT + LDRE ++ L V A+D G++P + V + V DVNDN
Sbjct: 316 IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNV 373
Query: 1146 PLTS-----EPIYYPVVM-ENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAIN 1199
P P+ VV+ EN P + + I D D+ N ++T P +
Sbjct: 374 PSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPV- 432
Query: 1200 IKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVY 1259
+ + LD E E+ +++ D G P + + ++V DENDN P F +
Sbjct: 433 FSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 492
Query: 1260 QIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF 1319
+ +PE + G + + A D D GPNAEI+Y ++ + +F +D +TGM++ K+
Sbjct: 493 TVSIPENN--SPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKL 549
Query: 1320 TAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV 1377
D + TI A DNG P +S + + I + SP+ F Y F V E+
Sbjct: 550 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPV---FTHNEYKFYVPENLPR 606
Query: 1378 TEIVGVVSVQPA----NTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSV 1433
VG+++V N+ + I+ N D D++ GV I+ D E++ Y V
Sbjct: 607 HGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNIS--FDREKQESYTFYV 664
Query: 1434 EVTDGTNV---AVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTE----ILQIEATD 1486
+ DG V + +V I V+D NDN P F P Y+ + E VLP T + Q+ A D
Sbjct: 665 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSY-ELVLPSTNPGTVVFQVIAVD 723
Query: 1487 RDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYR 1546
D +S + + F ID TG + E+ D D + ++V+ +
Sbjct: 724 NDTGMNAEVR-YSIVGGNTRDLFAIDQETGNITLMEKCD--VTDLGLHRVLVKANDLGQP 780
Query: 1547 RNLARVIV 1554
+L V++
Sbjct: 781 DSLFSVVI 788
Score = 216 bits (549), Expect = 5e-55
Identities = 185/699 (26%), Positives = 311/699 (44%), Gaps = 37/699 (5%)
Query: 2271 VTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDT 2330
V + L+ D+NDN P+F N ++ E S I + ++D D N + +Y++++
Sbjct: 144 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIK-- 201
Query: 2331 YNSTDYFHID-------SSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIY 2383
S + F +D ++ + LD E +KV+ D GFP SS ++ +
Sbjct: 202 --SQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 259
Query: 2384 ISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYS---ILSGNDRT 2440
++D NDN PVF + E + E AP G VT + A+DAD + ++ +S ++S R
Sbjct: 260 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 319
Query: 2441 SFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG-LFTSTAQVHIRVLGANLYSPAFSQS 2499
F +++ +G+IT+ + P + L V SDG L + A V + V N P+
Sbjct: 320 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 379
Query: 2500 TYVAEVR------ENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVI 2553
V V EN+ TK+ + TD D G+++ ++ + SN ++
Sbjct: 380 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLL 439
Query: 2554 TTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRAD 2612
LD E+ E + + + + V DENDNAP F S+ +
Sbjct: 440 ENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPEN 499
Query: 2613 VGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNT 2672
G + +V A D D G N+ I Y L +A + +D G + ++ K
Sbjct: 500 NSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFS----LDRRTGMLTVVKKLDREKED 555
Query: 2673 VLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRI 2732
F + A D G+P S + V++ ++ P FT ++Y F + E+ TV + +
Sbjct: 556 KYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITV 615
Query: 2733 LPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKV 2792
S V + N F I+ +TG I+ + DRE ++ F V A +V
Sbjct: 616 TDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDG-GRV 672
Query: 2793 DIVFTVDVDIKVLDLNDNKPVFETSSYD---TIIMEGMPVGTKLTQVRAIDMDWGANGQV 2849
+ V I V+D+NDNKPVF Y+ +++ GT + QV A+D D G N +V
Sbjct: 673 SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEV 732
Query: 2850 TYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTAL 2909
YS+ + + F ID TG I+ ++ D V A+DLG+ SL S +
Sbjct: 733 RYSIVGGN----TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 788
Query: 2910 VSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLST 2948
V++ V + NA + E+ R +++ P +A +S+
Sbjct: 789 VNLFVNESVTNATLI-NELVRKSIEAPVTPNTEIADVSS 826
Score = 215 bits (548), Expect = 7e-55
Identities = 189/663 (28%), Positives = 304/663 (45%), Gaps = 74/663 (11%)
Query: 429 IVTARPLNTVKKEVYKLEVTNKEGDLK-----AQVTISIEDANDHTPEFQQPLYDAYVNE 483
++ + L+ +K+ Y ++V ++G A + +S+ D ND+ P F++ + + E
Sbjct: 222 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 281
Query: 484 SVPVGTSVLTVSASDKDKGENGYITYSIASL--NLLP--FVINQFTGVISTTEELDFESS 539
+ PVGTSV + A+D D GEN I +S ++L N+ F +N TG+I+ E LD E +
Sbjct: 282 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 341
Query: 540 PEIYRFIVRASDWG-SPYRHESEVNVTIRIGNVNDNSP------LFEKVACQGVISYDFP 592
P ++ +V ASD G P R VNVT +VNDN P + V V+S + P
Sbjct: 342 PN-HKLLVLASDGGLMPARAMVLVNVT----DVNDNVPSIDIRYIVNPVNDTVVLSENIP 396
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ I ++ D D + + +E+ F S L+ + +A++
Sbjct: 397 LNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 456
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ A D A +N S + L IK K
Sbjct: 457 LLAAD----AGKPPLNQSAM-----------------------LFIKVKDE--------- 480
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
N P F +SF + V++ E+ G ++K+ A DADSG N ++ + +
Sbjct: 481 ------NDNAPVFTQSFVT-VSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE 533
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFI 832
F++D TG L V+ +DRE D YL I D G P +S + +++ D NDNSPVF
Sbjct: 534 -FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 592
Query: 833 QDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQL 892
+ Y + E+ + + D D G N VT S+L + F I+S TG++
Sbjct: 593 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 652
Query: 893 DRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI--PSSYSVK-VLEDL 949
DRE + +Y+ ++A D + + VT+ V DVND P FI P +YS + VL
Sbjct: 653 DREKQESYTFYVKAEDGGRVSRSSSAKVTINVV--DVNDNKPVFIVPPYNYSYELVLPST 710
Query: 950 PVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNL 1008
GTV+ + D D G+ +VRYS+V + F ID+ +G I L ++ D + +
Sbjct: 711 NPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRV 770
Query: 1009 TVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAR 1068
V+A D G+P SL SV V + VNE++ + V S++ T + V++
Sbjct: 771 LVKANDLGQPDSLFSVVIVN---LFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSP 827
Query: 1069 DED 1071
D
Sbjct: 828 TSD 830
Score = 214 bits (544), Expect = 2e-54
Identities = 218/804 (27%), Positives = 351/804 (43%), Gaps = 68/804 (8%)
Query: 1150 EPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS 1209
E I V++ N KD+++ I + ++ KL Y+ T P I TG I TT
Sbjct: 53 EEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYK-TGDVP--LIRIEEDTGEIFTTG 109
Query: 1210 RKLDREQ------QAEH-FLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIK 1262
++DRE+ + EH F EV V P + + + D NDN P FP V I
Sbjct: 110 ARIDREKLCAGIPRDEHCFYEVEVAIL-PDEIFRLVKIRFLIEDINDNAPLFPATVINIS 168
Query: 1263 LPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDG-NDDGKFFIDPKTG----MVSSRK 1317
+PE + A D D G N +Y ++ N G I+ G + +K
Sbjct: 169 IPENSAINSKYTL--PAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQK 226
Query: 1318 QFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESD 1375
+ D ++ +K D G PQ+SSTA L + P+ F E ++ E+
Sbjct: 227 ELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV---FKETEIEVSIPENA 283
Query: 1376 RVTEIVGVVSVQPA----NTPLWF---DIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSI 1428
V V + A N + F ++V F G I I +PLD E+
Sbjct: 284 PVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPN 343
Query: 1429 YNMSVEVTDGTNV-AVTQVFIKVLDNNDNGPEF------SQPNYDVTISEDVLPDTEILQ 1481
+ + V +DG + A V + V D NDN P + N V +SE++ +T+I
Sbjct: 344 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 403
Query: 1482 IEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 1541
I TD+D H T + + I R + + +L A LD+E+ ++ + ++ D
Sbjct: 404 ITVTDKDADHNGRVTCFTDHE-IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADA 462
Query: 1542 EFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAEL 1601
P A + + V+D ND++P FT S+ E+ + G +++V+A D D G NAE+
Sbjct: 463 GKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEI 522
Query: 1602 IYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661
Y + + F ++ G++T+ K+ D +++ +I D G PP+++ V +S+
Sbjct: 523 NYLL-GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSI 581
Query: 1662 TMSDNSHPKFIHKDYQAEVNENVDIGTSVILI----------SAISQSTLIYEVKDGDIN 1711
+++ P F H +Y+ V EN+ +V LI SA++ S L D N
Sbjct: 582 IDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL-------DEN 634
Query: 1712 GIFTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDENDNAPVF 1769
FTI+ +GVI + D E+ SY ++A + +S+A V I +VD NDN PVF
Sbjct: 635 DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF 694
Query: 1770 LFSQYSGSLSEAAPINSIVRSLDNSPLVIR--ATDADSNRNALLVYQIVESTAKKFFTVD 1827
+ Y+ S P S + +V + A D D+ NA + Y IV + F +D
Sbjct: 695 IVPPYNYSYELVLP------STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAID 748
Query: 1828 SSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAV 1887
TG I + D + V D G P + S V VN+ V + N + + V
Sbjct: 749 QETGNITLMEKCDVTDLGLHRVLVKANDLGQPD-SLFSVVIVNLFVNESVTNATLINELV 807
Query: 1888 FETILLLPTYVGVEVLKVSATDPD 1911
++I P E+ VS+ D
Sbjct: 808 RKSI-EAPVTPNTEIADVSSPTSD 830
Score = 205 bits (521), Expect = 1e-51
Identities = 198/700 (28%), Positives = 315/700 (45%), Gaps = 56/700 (8%)
Query: 2027 KIKSTSGVIQTTGVPFDRE---------EQELYELVVEASRELDHLRVARVV-VRVNIED 2076
+I+ +G I TTG DRE E YE+ V + + R+V +R IED
Sbjct: 97 RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD----EIFRLVKIRFLIED 152
Query: 2077 INDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL---QDDYGHFEIN 2133
INDN+P+F ++ ++ + A+D D G NG Y L Q+ +G I
Sbjct: 153 INDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIE 212
Query: 2134 PNSGNVILKEAFNSDLSNIE---YGVTILAKDGGKPSLSTS--VELPITIVNKAMPVFDK 2188
G+ + + +L E Y + + +DGG P S++ +++ +T N PVF +
Sbjct: 213 TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKE 272
Query: 2189 PFYTASVNEDIRMNTPILSINATSPE-GQGI-----IYIIIDGDPFKQFNIDFDTGVLKV 2242
S+ E+ + T + ++AT + G+ ++ + F+++ TG++ +
Sbjct: 273 TEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITI 332
Query: 2243 VSPLDYEVTSAYKLTIRASD-ALTGARAEVTVDLLVNDVNDNPPIFD-----QPTYNT-T 2295
PLD E T +KL + ASD L ARA V V+ V DVNDN P D P +T
Sbjct: 333 KEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVV 390
Query: 2296 LSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHE 2355
LSE + T + + D D+++N V D + S+ L+ A LD+E
Sbjct: 391 LSENIPLNTKIALITVTDKDADHNGRV--TCFTDHEIPFRLRPVFSNQFLLENAAYLDYE 448
Query: 2356 LVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTC 2415
+ +K+ + D+G P L+ ++ I + D NDN PVF Q + E G +
Sbjct: 449 STKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMK 508
Query: 2416 VQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG- 2474
V A+DADS + Y +L + F +D ++G++T+ + E Y + D
Sbjct: 509 VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNG 567
Query: 2475 --LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQIS 2532
TS V + ++ N SP F+ + Y V EN+ V + TD D G ++
Sbjct: 568 VPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVT 627
Query: 2533 YAIINDFAKDRFLIDSNGQVITTE-RLDRENPLEGDVSIFVRALDGG--GRTTFCTVRVI 2589
+I+++ D F IDS VI DRE + + +V+A DGG R++ V +
Sbjct: 628 LSILDE--NDDFTIDSQTGVIRPNISFDREK--QESYTFYVKAEDGGRVSRSSSAKVTIN 683
Query: 2590 VVDENDNAPQFMTVEYRAS---VRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVS 2646
VVD NDN P F+ Y S V G +V QV A+D D G N+ + YS+ +
Sbjct: 684 VVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI---VGGN 740
Query: 2647 VADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIP 2686
DL ID + G + + + VKA D G P
Sbjct: 741 TRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 780
Score = 202 bits (514), Expect = 6e-51
Identities = 182/698 (26%), Positives = 309/698 (44%), Gaps = 46/698 (6%)
Query: 1951 YMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNR 2010
Y + V + + + + ++++ D+ F + + SI EN+ +K + AV
Sbjct: 129 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 188
Query: 2011 --LNEPLKYSILNPGNKFKI---------KSTSGVIQTTGVPFDREEQELYELVVEASRE 2059
+N Y ++ N F + K ++Q DREE++ Y + V+
Sbjct: 189 VGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE---LDREEKDTYVMKVKVEDG 245
Query: 2060 LDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEV 2119
R + +++V++ D NDN PVF ++ +A GT + Q+ A D D G N ++
Sbjct: 246 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 305
Query: 2120 TYVLQDDYGH-----FEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVEL 2174
+ + + F +N +G + +KE + + + + +LA DGG V +
Sbjct: 306 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDRE-ETPNHKLLVLASDGGLMPARAMVLV 364
Query: 2175 PITIVNKAMPVFDKPFYTASVN------EDIRMNTPILSINATSPEGQ--GIIYIIIDGD 2226
+T VN +P D + VN E+I +NT I I T + G + D +
Sbjct: 365 NVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHE 424
Query: 2227 -PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDA-LTGARAEVTVDLLVNDVNDNP 2284
PF+ + + +L+ + LDYE T Y + + A+DA + + V D NDN
Sbjct: 425 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 484
Query: 2285 PIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSG 2344
P+F Q ++ E + G +++V + DADS N ++Y + D + F +D +G
Sbjct: 485 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPD---APPEFSLDRRTG 541
Query: 2345 LILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVS 2404
++ + LD E + + D+G P L+S V V + I D NDN PVF Y+ YV
Sbjct: 542 MLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVP 601
Query: 2405 ELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPL 2464
E PR V + +D D D + SIL ND F +DS++GVI + + +
Sbjct: 602 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQES 659
Query: 2465 YSLNVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTY---VAEVRENVAAGTKVIHV 2518
Y+ V DG +S+A+V I V+ N P F Y V + GT V V
Sbjct: 660 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 719
Query: 2519 RATDGDPGTYGQISYAIINDFAKDRFLID-SNGQVITTERLDRENPLEGDVSIFVRALDG 2577
A D D G ++ Y+I+ +D F ID G + E+ D + G + V+A D
Sbjct: 720 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTD--LGLHRVLVKANDL 777
Query: 2578 GGRTTFCTVRVIVVDENDNAPQFMTVE--YRASVRADV 2613
G + +V ++ + N++ + R S+ A V
Sbjct: 778 GQPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 815
Score = 195 bits (496), Expect = 8e-49
Identities = 190/680 (27%), Positives = 299/680 (43%), Gaps = 65/680 (9%)
Query: 2465 YSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGD 2524
Y + V++ ++ + N +P F + + EN A +K A D D
Sbjct: 129 YEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPD 188
Query: 2525 PGTYGQISYAII---NDFAKDRFLI---DSNGQVITTERLDRENPLEGDVSIFVRALDGG 2578
G G +Y +I N F D D Q+I + LDRE E D + ++ G
Sbjct: 189 VGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE---EKDTYVMKVKVEDG 245
Query: 2579 G---RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRI 2635
G R++ ++V V D NDN P F E S+ + G VTQ+ A D D G N++I
Sbjct: 246 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 305
Query: 2636 TYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVY 2695
+S + S L ++ G + K ++ + V A DGG+ ++ V
Sbjct: 306 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAM--VL 363
Query: 2696 IHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGI 2755
++V +PS +Y DT + S I + + TV + ++N
Sbjct: 364 VNVTDVNDNVPSI-DIRYIVNPVNDTVVLSE----NIPLNTKIALITVTDKDADHNGRVT 418
Query: 2756 FVIEQE---------TGTIKLDKR--LDRETSPAFHFKV----AATIPLDKVDIVFTVDV 2800
+ E + L+ LD E++ + K+ A PL++ ++F
Sbjct: 419 CFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF---- 474
Query: 2801 DIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPE 2860
IKV D NDN PVF S I E G +L +V A D D G N ++ Y L D+ PE
Sbjct: 475 -IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPE 533
Query: 2861 KVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDN 2920
F++D TG ++ +K LD E + + F+++A D G L+S V V + D NDN
Sbjct: 534 -----FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDN 587
Query: 2921 APVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQS 2980
+PVF Y+ V E+ P V +++ D D D N V+ I N F +
Sbjct: 588 SPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD-NSAVTLSILDEN--DDFTI----- 639
Query: 2981 EWKVYVKRP---LDREEQDIYFLNITATDGLFVTQ---AMVEVSVSDVNDNSPVC----D 3030
+ + V RP DRE+Q+ Y + A DG V++ A V ++V DVNDN PV
Sbjct: 640 DSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPY 699
Query: 3031 QVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLA 3089
+Y +LP P ++ +V A D D G N +RYS+ G + F +D E+G + +
Sbjct: 700 NYSYELVLPSTNPGT-VVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLME 758
Query: 3090 LLDRERIPVYSLMAKATDGG 3109
D + ++ ++ KA D G
Sbjct: 759 KCDVTDLGLHRVLVKANDLG 778
Score = 180 bits (457), Expect = 3e-44
Identities = 188/676 (27%), Positives = 317/676 (46%), Gaps = 66/676 (9%)
Query: 1424 EQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIE 1483
++ Y + V + + ++ + D NDN P F +++I E+ +++
Sbjct: 124 DEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPA 183
Query: 1484 ATDRD------EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIM 1537
A D D + ++L + +I + + + L + LD E +D +++ +
Sbjct: 184 AVDPDVGINGVQNYELIKS--QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVK 241
Query: 1538 VRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGE 1597
V D FP R + A + V+V D ND+ P F E S+ E+A +G++V Q+ A D D GE
Sbjct: 242 VEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGE 301
Query: 1598 NAELIYT---IEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSAT 1654
NA++ ++ + + +F + G+ITI + D L + +D G P A
Sbjct: 302 NAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--AR 359
Query: 1655 AIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDGDING-- 1712
A+V ++VT +++ P + VN+ V + ++ L + I+ T+ KD D NG
Sbjct: 360 AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV--TDKDADHNGRV 417
Query: 1713 --------IFTINP-YSGVITTQKA--LDYERTSSYQLIIQATNMA--GMASNATVNIQI 1759
F + P +S + A LDYE T Y + + A + + +A + I++
Sbjct: 418 TCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKV 477
Query: 1760 VDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSP----LVIRATDADSNRNALLVYQI 1815
DENDNAPVF S + S+ E +NSP + + ATDADS NA + Y +
Sbjct: 478 KDENDNAPVFTQSFVTVSIPE-----------NNSPGIQLMKVSATDADSGPNAEINY-L 525
Query: 1816 VESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTD 1875
+ A F++D TG + + LD E + F + +D+G P LT S V V + + D
Sbjct: 526 LGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLT--SNVTVFVSIID 583
Query: 1876 VNDNPPVFTQAVFETIL--LLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLID 1933
NDN PVFT ++ + LP + V ++ V TDPD +T S+++ + D F ID
Sbjct: 584 QNDNSPVFTHNEYKFYVPENLPRHGTVGLITV--TDPDYGDNSAVTLSILDEN-DDFTID 640
Query: 1934 SNSGVL--TIKNNNLSKDHYMLIVKVSDG---KFYSTSMVTIMVKEAMDSGLHFTQSFYS 1988
S +GV+ I + ++ Y VK DG S++ VTI V + D+ F Y+
Sbjct: 641 SQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYN 700
Query: 1989 TS---ISENNTNITKVAIVNAVGN--RLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVP 2041
S + + T V V AV N +N ++YSI+ N + F I +G I T
Sbjct: 701 YSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI-TLMEK 759
Query: 2042 FDREEQELYELVVEAS 2057
D + L+ ++V+A+
Sbjct: 760 CDVTDLGLHRVLVKAN 775
Score = 177 bits (449), Expect = 2e-43
Identities = 163/563 (28%), Positives = 264/563 (46%), Gaps = 58/563 (10%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKV-NIQVLDMNDLRPLFSPTTYSVTIAESTPLRT 175
L+RE +D Y++ VK G + T + + V D ND P+F T V+I E+ P+ T
Sbjct: 228 LDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGT 287
Query: 176 SVAQVTATDADIGSNGEFYYYFKNKVD-----LFSVHPTSGVISLSGRLNYDEKNRYDLE 230
SV Q+ ATDADIG N + ++ F N V LF ++ T+G+I++ L+ +E + L
Sbjct: 288 SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLL 347
Query: 231 ILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHV------VTHVPFSLEKEP---T 281
+LA D G+ + + A + V++ +N++ P+I + V E P
Sbjct: 348 VLASDGGL-------MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTK 400
Query: 282 YAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGY 341
A++TV D D NG + + D F L + N++ ++ +D+ES Y
Sbjct: 401 IALITVTDKDADHNGRVTCFT----DHEIPFRL--RPVFSNQFLLENAAYLDYES-TKEY 453
Query: 342 NLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLS 401
+ L A D G P + D P+ F + VSI E + PG + ++K+S
Sbjct: 454 AIKLLAADAGKPPLNQSAMLFIKVKDENDNAPV-FTQSFVTVSIPENNSPG--IQLMKVS 510
Query: 402 PEPID------VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDL- 454
D + Y L P + F ++ R+G++ + L+ K++ Y + K+ +
Sbjct: 511 ATDADSGPNAEINYLLGP-DAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 569
Query: 455 ----KAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYS 510
V +SI D ND++P F Y YV E++P +V ++ +D D G+N +T S
Sbjct: 570 PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLS 629
Query: 511 IASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGN 570
I N F I+ TGVI D E E Y F V+A D G R S VTI + +
Sbjct: 630 ILDEN-DDFTIDSQTGVIRPNISFDREKQ-ESYTFYVKAEDGGRVSR-SSSAKVTINVVD 686
Query: 571 VNDNSPLFEKVACQGVISYDFPV-----GGHITAVSAIDIDE--LELVKYKIISGNELGF 623
VNDN P+F + SY+ + G + V A+D D V+Y I+ GN
Sbjct: 687 VNDNKPVF--IVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL 744
Query: 624 FYLNPDSGVLQL--KKSLTNSGI 644
F ++ ++G + L K +T+ G+
Sbjct: 745 FAIDQETGNITLMEKCDVTDLGL 767
Score = 135 bits (341), Expect = 7e-31
Identities = 170/722 (23%), Positives = 305/722 (42%), Gaps = 90/722 (12%)
Query: 129 VKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIG 188
V+ ++ +++ K+ + D+ND PLF T +++I E++ + + A D D+G
Sbjct: 131 VEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVG 190
Query: 189 SNGEFYYYFKNKVDLFS---VHPTSG----VISLSGRLNYDEKNRYDLEILAVDRGMKLY 241
NG Y ++F + G + + L+ +EK+ Y +++ D G
Sbjct: 191 INGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR 250
Query: 242 GNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSL-EKEPTYAVVT---VDDLDDGANGE 297
SSTA L V + N++ P + T + S+ E P VT D D G N +
Sbjct: 251 -----SSTAILQVSVTDTNDNHP-VFKETEIEVSIPENAPVGTSVTQLHATDADIGENAK 304
Query: 298 IE-SVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKG-SPQK 355
I S S + + + F L I ++ +D E P + L + A D G P +
Sbjct: 305 IHFSFSNLVSNIARRLFHLNATTGL----ITIKEPLDREETP-NHKLLVLASDGGLMPAR 359
Query: 356 CSALKAVYIGNPTRDTVPIRF-EKEVYD-VSISEFSPPGVVVAIVKLSPEPIDVEYKLSP 413
L V N ++ IR+ V D V +SE P +A++ ++ + D +++
Sbjct: 360 AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC 419
Query: 414 GED-AVYFKINP---RSGLIVTARPLNTVKKEVYKLEVTNKEG-----DLKAQVTISIED 464
D + F++ P L+ A L+ + Y +++ + + A + I ++D
Sbjct: 420 FTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKD 479
Query: 465 ANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQF 524
ND+ P F Q + E+ G ++ VSA+D D G N I Y + F +++
Sbjct: 480 ENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRR 539
Query: 525 TGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
TG+++ ++LD E + Y F + A D G P S V V + I + NDNSP+F +
Sbjct: 540 TGMLTVVKKLDREKEDK-YLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYK 597
Query: 585 GVISYDFPVGGHITAVSAIDID--ELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNS 642
+ + P G + ++ D D + V I+ N+ F ++ +GV++ S
Sbjct: 598 FYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDRE 655
Query: 643 GIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKA 702
K ++ + A DG G+VS S A
Sbjct: 656 --KQESYTFYVKAEDG---------------GRVSRSS--------------------SA 678
Query: 703 NGKLNLEDGFLDFYSINRQGPYF---DKSFPSDVAVKEDLPVGANILKIKAYDADSGFNG 759
+N+ D +N P F ++ ++ + P G + ++ A D D+G N
Sbjct: 679 KVTINVVD-------VNDNKPVFIVPPYNYSYELVLPSTNP-GTVVFQVIAVDNDTGMNA 730
Query: 760 KVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTI 819
+V ++I GNT F ID ETG + ++ D L+ + + DLG P S + ++ +
Sbjct: 731 EVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPD-SLFSVVIV 789
Query: 820 NV 821
N+
Sbjct: 790 NL 791
Score = 126 bits (316), Expect = 6e-28
Identities = 133/492 (27%), Positives = 216/492 (43%), Gaps = 38/492 (7%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMND------LRPLFSPTTYSVTIAES 170
L+RE N+ L+V S G + A V + V D+ND +R + +P +V ++E+
Sbjct: 336 LDREETPNHKLLVLASDGGL-MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSEN 394
Query: 171 TPLRTSVAQVTATDADIGSNGEFYYYFKNKVD--LFSVHPTSGVISLSGRLNYDEKNRYD 228
PL T +A +T TD D NG + +++ L V ++ + L+Y+ Y
Sbjct: 395 IPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYA 454
Query: 229 LEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTI---HVVTHVPFSLEKEPTYAVV 285
+++LA D G ++ +A L++ ++ N++AP V +P + V
Sbjct: 455 IKLLAADAGKP-----PLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKV 509
Query: 286 TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTL 345
+ D D G N EI ++ D +F L + L K +R++ D Y T+
Sbjct: 510 SATDADSGPNAEINY--LLGPDAPPEFSLDRRTGMLTVVKKLDREKED------KYLFTI 561
Query: 346 QAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPP-GVVVAIVKLSPEP 404
AKD G P S + D P+ F Y + E P G V I P+
Sbjct: 562 LAKDNGVPPLTSNVTVFVSIIDQNDNSPV-FTHNEYKFYVPENLPRHGTVGLITVTDPDY 620
Query: 405 IDVE-YKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG-----DLKAQV 458
D LS ++ F I+ ++G+I + K+E Y V ++G A+V
Sbjct: 621 GDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKV 680
Query: 459 TISIEDANDHTPEFQQPLYD---AYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN 515
TI++ D ND+ P F P Y+ V S GT V V A D D G N + YSI N
Sbjct: 681 TINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGN 740
Query: 516 LLP-FVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDN 574
F I+Q TG I+ E+ D + ++R +V+A+D G P S V V + + N
Sbjct: 741 TRDLFAIDQETGNITLMEKCDV-TDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTN 799
Query: 575 SPLFEKVACQGV 586
+ L ++ + +
Sbjct: 800 ATLINELVRKSI 811
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
Length = 1886
Score = 271 bits (694), Expect = 8e-72
Identities = 300/1101 (27%), Positives = 464/1101 (42%), Gaps = 133/1101 (12%)
Query: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 249
Query: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
D I YS+ + P + N+ + +KA
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
Query: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 370 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
Query: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 485
Query: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 486 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
Query: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASD------------- 2897
Y + +Q + F I+ TG I+ ++ T+ +V A+D
Sbjct: 546 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
Query: 2898 LGEAFSL-------------------SSTALVSVRVTDINDNAPVFAQEVYRGNVKESDP 2938
LG+A +STA V++ VTD+NDNAPVF + R +
Sbjct: 601 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 660
Query: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIY 2998
V + D D + +N QV Y + GN F + S +Y L+RE +D Y
Sbjct: 661 ANAFVGQVKATDPD-AGINGQVHYSL--GNFNNLFR---ITSNGSIYTAVKLNREVRDYY 714
Query: 2999 FLNITATDGLF---VTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKD 3055
L + ATDG + + + V D++DNSPV YT L+ E++P+ IL++ AKD
Sbjct: 715 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 774
Query: 3056 ADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLALLDRERIP----VYSLMAKATDGGG 3110
D+G+N + Y + FF L P +GEL L LD E P + + +A D G
Sbjct: 775 VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 832
Query: 3111 RFCQ--SNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD-IGINRKVV 3167
+ + +I++D+ND PPVFS Y V + +T V A D D G+ V
Sbjct: 833 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 892
Query: 3168 YSLADSA-----GGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTV 3222
D +F ++ SG +I L+ E + + + V A D +SS TV
Sbjct: 893 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE-PVMSSSATV 951
Query: 3223 TITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQG 3282
I VL + P + V E + GT V + A + N I Y I SGNE+
Sbjct: 952 KILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA----INQSIVYSIVSGNEED 1007
Query: 3283 KFKINPKTGGISVSEVLDYELCKRFYLVVEA-------KDGGTPALSAVATVNINLTDVN 3335
F IN TG I V+ LDYE + L V+A + P+ S A V I + D N
Sbjct: 1008 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1067
Query: 3336 DNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIV---NGDRDNEFTVD 3392
++PP F + Y +SEDA + SV+ + A D D+ + + ++ + F V+
Sbjct: 1068 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1127
Query: 3393 PVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYT 3452
GL+K R S + V A D +S A V + + + D + + T
Sbjct: 1128 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1187
Query: 3453 AVIQENKPVGTSILQLVVTDR 3473
V ++ + + T IL V ++
Sbjct: 1188 LVEKKIEDL-TEILDRYVQEQ 1207
Score = 271 bits (693), Expect = 1e-71
Identities = 294/1106 (26%), Positives = 480/1106 (43%), Gaps = 142/1106 (12%)
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 81 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 135
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLVT-----QVQAIDPDDGANSRITYSL-YSE 2642
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 136 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
Query: 2643 ASVSVADLLEI-----------------DPDNGWMVTKGN-----FNQLKNTVLSFFVKA 2680
+ D EI D +++ + N N+ + T + V
Sbjct: 196 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 255
Query: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
+DG L P+++ VL P T +P + I I +
Sbjct: 256 LDGD-----DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
I P + + +S + G + + F + T + L + ++R+ FH K
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPR--FFHMHPRTAELSLLEPVNRD----FHQKFDLV 364
Query: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 485 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 540
Query: 2957 NRQVSYHITGGNPRGRFAL----GLV----------------------------QSEWKV 2984
N +++Y I G +G F + GL+ +S +
Sbjct: 541 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGIL 599
Query: 2985 YVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDI 3042
+ + LDRE D Y L ITA+DG + A V + V+DVNDN+PV D L +
Sbjct: 600 TLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 659
Query: 3043 PSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLM 3102
+N + +V A D D G NG + YSL N F +G + T L+RE Y L+
Sbjct: 660 EANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIYTAVKLNREVRDYYELV 717
Query: 3103 AKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDI 3160
ATDG S + L ++ D++DN PVF++ Y V EN + +++A D D+
Sbjct: 718 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 777
Query: 3161 GINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQSSYNISVRATDQSPGQS 3215
G N V Y + + F++ +G + L + LD E Q++S V A D G
Sbjct: 778 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIY-GTM 834
Query: 3216 LSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLI 3275
+ TVT+ V D+ND PPVF +R Y V D GT + V+A D
Sbjct: 835 PPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 894
Query: 3276 RSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNIN 3330
R + Q F++ +G + L+ E F LVV A D G P +S+ ATV I
Sbjct: 895 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKIL 954
Query: 3331 LTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEF 3389
+ + P +F+Q+ Y +SE A G V ++ A + N I +SIV+G+ ++ F
Sbjct: 955 VLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTF 1009
Query: 3390 TVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAMSSTATVNIDISDVNDN 3442
++ + G++ V LD E + Y L VQA + +P+ S+TA V I+I D N++
Sbjct: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
Query: 3443 SPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEE--EEFVLDPH 3500
PVF Y + E+ + TS+L++ TD+D+ + I+ +E E FV++ +
Sbjct: 1070 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1129
Query: 3501 -GILRSAVVFQHTESLEYVLCVQAKD 3525
G++++A++F + + V A D
Sbjct: 1130 TGLIKTAMLFHNMRRSYFKFQVIATD 1155
Score = 269 bits (687), Expect = 5e-71
Identities = 312/1173 (26%), Positives = 523/1173 (44%), Gaps = 167/1173 (14%)
Query: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 128
Query: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI-----AWLETHDPDLGLGGQ 970
++ V ++ + D ND SP F SY V E PVGT I D D G GQ
Sbjct: 129 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
Query: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 187 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
Query: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 247 TTTTLTVDVLDGDD--LGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
Query: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 305 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Query: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 364 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
Query: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGL--ITTTSRKLDREQQAEHFLEVT 1225
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 482
Query: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 483 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 538
Query: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDN--------- 1334
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN
Sbjct: 539 GSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTG 597
Query: 1335 ------------------------GRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFY--N 1368
GRP +STA ++I +P+ FD P+ N
Sbjct: 598 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV---FD-PYLPRN 653
Query: 1369 FTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQ 1425
+V+E + + V + P N + + + GNF++ F G+I A L+ E
Sbjct: 654 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNREV 710
Query: 1426 RSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQI 1482
R Y + V TDG + + IKVLD +DN P F+ Y V + E++ T ILQI
Sbjct: 711 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 770
Query: 1483 EATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1542
EA D D +SY + S F + P TG L LD+EA +I +
Sbjct: 771 EAKDVDLGANVSYRIRS---PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 827
Query: 1543 F----PYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKD-KGE 1597
F +A V V V+D ND+ P F+ +Y+ V A G+ + V A D D G
Sbjct: 828 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 887
Query: 1598 NAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSIKVTDQGSP 1649
A + ++ ++F++E V+ + + +EP TT+ F L + D G P
Sbjct: 888 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVVVAFDDGEP 943
Query: 1650 PMSATAIVRISVTMSDNSHPKFIHKDYQ-AEVNENVDIGTSVILISAIS-QSTLIYEVKD 1707
MS++A V+I V + P+F ++Y+ V+E GT V +ISA + +++Y +
Sbjct: 944 VMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1002
Query: 1708 GDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN---------ATVNIQ 1758
G+ F IN +GVI LDYE +SY L +QA ++ + +N A V I+
Sbjct: 1003 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1062
Query: 1759 IVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV-- 1816
I DEN++ PVF Y G +SE A + S L ++ATD D+ +++ Y+++
Sbjct: 1063 IQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSVMAYRLIIP 1115
Query: 1817 -ESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV------EV 1869
K+ F V++ TG I+T + ++F F V D L+ ++ V ++
Sbjct: 1116 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1175
Query: 1870 NIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
+++V N P + + + + +L YV ++
Sbjct: 1176 DMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1208
Score = 250 bits (639), Expect = 2e-65
Identities = 245/886 (27%), Positives = 400/886 (45%), Gaps = 102/886 (11%)
Query: 761 VLFTISDGNTDSC---FNIDMETGQLKVLMPMDRE-HTDLYLLNITIYDLGNPQKSSWRL 816
+L++I G + F++ T +L +L P++R+ H L+ D G+P + +
Sbjct: 322 ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPA-FAG 380
Query: 817 LTINVEDANDNSPVFIQDSYSVNILESSGIGTEI---------IQVEARDKDLGSNGEVT 867
L I + D N+ SP F SY ILES+ +G I +++ A DKD+ +
Sbjct: 381 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE 440
Query: 868 YSV-LTDTQQFAINSSTGI---VYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLK 923
+ L D + TGI + + +DRE + Y+ I A D + + + +V ++
Sbjct: 441 LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV--IVNIQ 498
Query: 924 VFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRF 983
V D ND +P F SY V V D+ G + L D D G G++ Y ++ G F
Sbjct: 499 VM--DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDF 556
Query: 984 EIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLS--------------------- 1022
I+K +G I ++ ++ + Y LTV+A D P S
Sbjct: 557 IINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILI 616
Query: 1023 -----------SVSFVEVEVVDVNEN--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARD 1069
S + V + V DVN+N + PY P V + N+ +G QV A D
Sbjct: 617 ITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG----QVKATD 672
Query: 1070 EDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLY 1129
D+G +G++ YS+ + + L R + +G I A L+RE Y L V ATD V P +
Sbjct: 673 PDAGINGQVHYSLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRH 729
Query: 1130 STIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITS 1189
ST+ + I+V D++DN+P+ + Y +V EN P +++QI+A+D D +N ++YRI S
Sbjct: 730 STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRS 787
Query: 1190 GNPQNFFAINIKTGLITTTSRKLDRE----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQ 1243
++FFA++ TG ++ R LD E Q+A V D G P +T+ V+V+
Sbjct: 788 PEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK 846
Query: 1244 VLDENDNKPQFPEKVYQ-IKLPERDRKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN- 1299
D ND P F +++Y+ + P+ +G PI +A D D P + + Y + D
Sbjct: 847 --DMNDYPPVFSKRIYKGMVAPD---AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF 901
Query: 1300 --DDGKFFIDPKTGMVSSRKQFTAGSYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPP 1355
F ++ +G V +R I L + A D+G P SS+A + I + P
Sbjct: 902 PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH---P 958
Query: 1356 SPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTI 1415
IP E + V E +VGV+S N + + IV GN + F G I
Sbjct: 959 GEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVI 1018
Query: 1416 VIAKPLDAEQRSIYNMSVEVTDGTNVAV-----------TQVFIKVLDNNDNGPEFSQPN 1464
+ PLD E R+ Y + V+ D V + +V+I++ D N++ P F +
Sbjct: 1019 YVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1077
Query: 1465 YDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAE 1522
Y +SED T +L+++ATD+D + I I K F ++ TG++ TA
Sbjct: 1078 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAM 1137
Query: 1523 RLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTN 1568
+ + ++ D A V+V+V + D +N
Sbjct: 1138 LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1183
Score = 231 bits (589), Expect = 1e-59
Identities = 275/1052 (26%), Positives = 440/1052 (41%), Gaps = 161/1052 (15%)
Query: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 393
Query: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 446
Query: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 503
Query: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 504 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 560
Query: 1096 ESGVIT------------------AAD----------------ILDRETMGSYWLTVYAT 1121
+G+IT AAD LDRE+ Y L + A+
Sbjct: 561 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITAS 620
Query: 1122 DRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNE 1181
D G ST V I V DVNDNAP+ + + + + V Q++A DPD+ N
Sbjct: 621 D-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 679
Query: 1182 KLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVV 1241
++ Y + GN N F I + T KL+RE + + L V TDG P+ ST+ +
Sbjct: 680 QVHYSL--GNFNNLFRITSNGSIYTAV--KLNREVRDYYELVVVATDGAVHPRHSTLTLA 735
Query: 1242 VQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDD 1301
++VLD +DN P F Y + + E G I + A D D G N +SY I
Sbjct: 736 IKVLDIDDNSPVFTNSTYTVLVEE--NLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVK 791
Query: 1302 GKFFIDPKTGMVSSRKQFTAGSYD------ILTIKAVD--NGRPQKSSTARLHIEWIKKP 1353
F + P TG +S + ++ ++A D P +T + ++ +
Sbjct: 792 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 851
Query: 1354 PPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTP------LWFDIVGGNFD---S 1404
PP F + Y V + V + A+ P + + + F S
Sbjct: 852 PP-----VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS 906
Query: 1405 AFDAEKGVGTIVIAKPLDAEQRSIYNM-SVEVTDGTNVAVTQVFIKVLDNNDNG-PEFSQ 1462
F+ E+ G ++ L+ E +I+ + V DG V + +K+L + P F+Q
Sbjct: 907 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 966
Query: 1463 PNY-DVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTA 1521
Y +SE T + I A ++ V+S + F I+ TGV+Y
Sbjct: 967 EEYRPPPVSELATKGTMVGVISAAAINQS-----IVYSIVSGNEEDTFGINNITGVIYVN 1021
Query: 1522 ERLDHEAQDKHILNIMVRDQE-------FPYRRNLARVIVNVEDANDHSPYFTNPLYEAS 1574
LD+E + ++L + E P + N A+V + ++D N+H P F Y
Sbjct: 1022 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1081
Query: 1575 VFESAALGSAVLQVTALDKDKGENAELIY-----TIEAGNTGNMFKIEPVLGIITICKEP 1629
V E A + ++VL+V A DKD G + + Y I+ G G F +E G+I
Sbjct: 1082 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLF 1139
Query: 1630 DMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661
F + TD +S A V +SV
Sbjct: 1140 HNMRRSYFKFQVIATDDYGKGLSGKADVLVSV 1171
Score = 229 bits (585), Expect = 4e-59
Identities = 285/1057 (26%), Positives = 456/1057 (43%), Gaps = 157/1057 (14%)
Query: 289 DLDDGANGEIESV-SIVAGDPL--DQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTL 345
D+DDG NG+IE V DP D F E + I RK++++E Y + +
Sbjct: 178 DIDDGPNGQIEYVIQYNPDDPTSNDTF----EIPLMLTGNIVLRKRLNYED-KTRYFVII 232
Query: 346 QAKDK--------------------GSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSI 385
QA D+ G L V + N TRD P+ Y +I
Sbjct: 233 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN-TRDCRPL-----TYQAAI 286
Query: 386 SEFSPPGVVVAIVKLSP-EPIDVEYKLSPGEDAV----------------YFKINPRSGL 428
E P + I+ P + ID + + P D +F ++PR+
Sbjct: 287 PELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE 346
Query: 429 IVTARPLNTVKKEVYKLEVTNKEGD-----LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+ P+N + + L + ++ + A + I I D N+ +P F P Y Y+ E
Sbjct: 347 LSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILE 406
Query: 484 SVPVG---------TSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEE- 533
S PVG TS L + A DKD + L+L +N +T V + T+
Sbjct: 407 SAPVGATISDSLNLTSPLRIVALDKDIEDT-----KDPELHLF---LNDYTSVFTVTQTG 458
Query: 534 ----------LDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVAC 583
+D E + Y F + A D + V V I++ + NDN+P F +++
Sbjct: 459 ITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEISY 514
Query: 584 QGVISYDFPVGGHITAVSAIDIDELEL--VKYKIISGNELGFFYLNPDSGVLQLKKSLTN 641
+ D G + ++A+D DE + Y+I+ G + G F +N +G++ + +
Sbjct: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEM 573
Query: 642 SGIKNGNFALRITATDGENLADPMSINISVLH-GKVSSKSFSCRETRVAQKLAEKLLIKA 700
I +AL + A D A P + +L GK + + R + + +
Sbjct: 574 --IVGRTYALTVQAADN---APPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTS 628
Query: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
A + + D +N P FD P +++V E+ A + ++KA D D+G NG+
Sbjct: 629 TATVNIVVTD-------VNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQ 680
Query: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTIN 820
V +++ GN ++ F I G + + ++RE D Y L + D + S L I
Sbjct: 681 VHYSL--GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 737
Query: 821 VEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ--FA 878
V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N V+Y + + + FA
Sbjct: 738 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 795
Query: 879 INSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
++ TG + + LD E+ +A+ + +EA D G + T+ V + D+ND P
Sbjct: 796 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPP 853
Query: 935 AFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSLVNDYN-----GRFEIDK 987
F Y V D GT I + E DP +VRY V+D FE+++
Sbjct: 854 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR-VDDVQFPYPASIFEVEE 912
Query: 988 ASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFA 1047
SG + L+ E + L V A D G PV +SS + V++ V LH P F
Sbjct: 913 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILV------LHPGEIPRFT 965
Query: 1048 V----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAA 1103
V E + GT V ++A + + I YSI G+ F I++ +GVI
Sbjct: 966 QEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVN 1021
Query: 1104 DILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVEDVNDNAPLTSEPIYYPV 1156
LD ET SY L V A VV +T +VYIE++D N++ P+ + Y
Sbjct: 1022 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1081
Query: 1157 VMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFFAINIKTGLITTTSRKLD 1213
V E++ SV++++A D D+ + + YR+ + F + TGLI T L
Sbjct: 1082 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLF 1139
Query: 1214 REQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
+ +F +V TD G S K + VV LD
Sbjct: 1140 HNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
Score = 221 bits (564), Expect = 1e-56
Identities = 266/1050 (25%), Positives = 442/1050 (42%), Gaps = 158/1050 (15%)
Query: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
Query: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
Query: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 219 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 275
Query: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
++Y + T + AID D + + Y I+ G
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 387
Query: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
E+ ++++ Y +S P + + L +
Sbjct: 388 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 421 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
Query: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 480 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTG 597
Query: 919 VVTLKVFLD-------------------------------DVNDCSPAFIP-SSYSVKVL 946
++TL LD DVND +P F P ++ V+
Sbjct: 598 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 657
Query: 947 EDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFY 1006
E+ + ++ DPD G+ GQV YSL N +N F I ++G+I + +L+ E + +Y
Sbjct: 658 EE-EANAFVGQVKATDPDAGINGQVHYSLGN-FNNLFRI-TSNGSIYTAVKLNREVRDYY 714
Query: 1007 NLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVT 1066
L V A D G S + ++V+D+++N +P F + V+EN GT++LQ+
Sbjct: 715 ELVVVATD-GAVHPRHSTLTLAIKVLDIDDN--SPVFTNSTYTVLVEENLPAGTTILQIE 771
Query: 1067 ARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETM----GSYWLTVYATD 1122
A+D D G + Y IR F++ +G ++ LD E S V A D
Sbjct: 772 AKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
Query: 1123 -RGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAE--DPDSSS 1179
G +P V + V+D+ND P+ S+ IY +V ++ K + + AE DP
Sbjct: 830 IYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 888
Query: 1180 NEKLTYRITSGN---PQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQS 1236
++ YR+ P + F + +G + T L+ E L V D G S
Sbjct: 889 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV-NLNEEPTTIFKLVVVAFDDGEPVMSS 947
Query: 1237 TIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIV 1296
+ V + VL + P+F ++ Y+ P + +G + A N I YSIV
Sbjct: 948 SATVKILVLHPGE-IPRFTQEEYR-PPPVSELATKGTMVGVISA----AAINQSIVYSIV 1001
Query: 1297 DGNDDGKFFIDPKTGMVSSRKQF---TAGSY------DILTIKAVDNGRPQKSSTARLHI 1347
GN++ F I+ TG++ T SY D L + + P KS+TA+++I
Sbjct: 1002 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1061
Query: 1348 EWIKKPPPSPIPLTFDEPFYNFTVMESDRV 1377
E + P+ F + FY V E R+
Sbjct: 1062 EIQDENNHPPV---FQKKFYIGGVSEDARM 1088
Score = 212 bits (540), Expect = 6e-54
Identities = 263/1045 (25%), Positives = 436/1045 (41%), Gaps = 160/1045 (15%)
Query: 2035 IQTTGVPFDREE-QELYELVVEASRELDHLRVARVV---VRVNIEDINDNSPVFVGLPYY 2090
+ +TG DR+ ++ +VV+ + + +V ++ VR+ + D NDNSP F YY
Sbjct: 96 LNSTGRVLDRDPPMNIHSIVVQV--QCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYY 153
Query: 2091 AAVQVDAEPGTLIY-----QVTAIDKDKGPNGEVTYVLQ---DD---YGHFEIN-PNSGN 2138
A V GT I+ A D D GPNG++ YV+Q DD FEI +GN
Sbjct: 154 ATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN 213
Query: 2139 VILKEAFNSDLSNIEYGVTILAKD-----GGKPSLSTSVELPITIVNKAMPVF------- 2186
++L++ N + Y V I A D + + +T++ + + + P+F
Sbjct: 214 IVLRKRLNYE-DKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVP 272
Query: 2187 ----DKPF-YTASVNE--------DIRMNTPILSI----NATSPEGQ-GIIYIIIDGDPF 2228
+P Y A++ E I + PI +I N P + GI+Y I+ G P
Sbjct: 273 NTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE 332
Query: 2229 ---KQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASD-------ALTGARAEVTVDLLVN 2278
+ F++ T L ++ P++ + + L I+A A G E+
Sbjct: 333 DYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL------ 386
Query: 2279 DVNDNPPIFDQPTYNTTLSEASLIG---------TPVLQVVSIDADSENNKMVHYQIVQD 2329
D N+ P F P+Y + E++ +G T L++V++D D E+ K + +
Sbjct: 387 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLN 446
Query: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
Y S + + + +D E Q T + + D S V+V+I + D ND
Sbjct: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDAND 504
Query: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSG-------NDRTSF 2442
N P F ++ Y+ YV G V + A DAD + Y IL G N T
Sbjct: 505 NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGL 564
Query: 2443 L--------------------------MDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
+ + +G++TL + Y L ++ SDG
Sbjct: 565 ITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRP 624
Query: 2476 -FTSTAQVHIRVLGAN----LYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQ 2530
TSTA V+I V N ++ P ++ V E N G V+ATD D G GQ
Sbjct: 625 DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQ 680
Query: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGG--GRTTFCTVRV 2588
+ Y++ N + F I SNG + T +L+RE + + V A DG R + T+ +
Sbjct: 681 VHYSLGN--FNNLFRITSNGSIYTAVKLNRE--VRDYYELVVVATDGAVHPRHSTLTLAI 736
Query: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVA 2648
V+D +DN+P F Y V ++ G + Q++A D D GAN ++Y + S V
Sbjct: 737 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRI---RSPEVK 791
Query: 2649 DLLEIDPDNGWMVTKGNFNQL----KNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETF 2704
+ P G + + + + ++F V+A D + + V + V +
Sbjct: 792 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 851
Query: 2705 LPSFTQSQYSFTIAEDTAIGSTVDTLRI-------LPSQNVWFSTVNGERPENNKGGIFV 2757
P F++ Y +A D G+ + T+ LP+ V + + + P IF
Sbjct: 852 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP--YPASIFE 909
Query: 2758 IEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNK-PVFET 2816
+E+++G + L+ E + F V A D + V + +K+L L+ + P F
Sbjct: 910 VEEDSGRVITRVNLNEEPTTIFKLVVVA---FDDGEPVMSSSATVKILVLHPGEIPRFTQ 966
Query: 2817 SSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWIS 2876
Y + + TK T V I N + YS+ S ++ + F I++ TG I
Sbjct: 967 EEYRPPPVS--ELATKGTMVGVISAA-AINQSIVYSIVSGNEE----DTFGINNITGVIY 1019
Query: 2877 TLKDLDHETDPTFTFSVVASDLGEAF------SLSSTALVSVRVTDINDNAPVFAQEVYR 2930
LD+ET ++ V A L S S+TA V + + D N++ PVF ++ Y
Sbjct: 1020 VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYI 1079
Query: 2931 GNVKESDPPGEVVAVLSTWDRDTSD 2955
G V E V + D+DT +
Sbjct: 1080 GGVSEDARMFTSVLRVKATDKDTGN 1104
Score = 211 bits (537), Expect = 1e-53
Identities = 267/1071 (24%), Positives = 442/1071 (41%), Gaps = 154/1071 (14%)
Query: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 926 LDDVNDCSPAFIP-----------------SSYSVKVLEDLPVGTVIAWLETHDPDLGLG 968
+ D +D P F+P + ++ E+L V ++ D D +
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRA-KDKGRP 1018
+ YS++ DY F + + + L + ++ + Q ++L ++A +D G P
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
Query: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 375 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
Query: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
Query: 1188 TSGNPQNFFAINIKTGLIT---------------------------------TTSRKLDR 1214
G Q F IN TGLIT T + LDR
Sbjct: 549 LVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDR 607
Query: 1215 EQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKRGE 1273
E + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 608 ESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-- 664
Query: 1274 PIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIKAV 1332
+ + A D D G N ++ YS+ GN + F I + ++ K Y L + A
Sbjct: 665 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 721
Query: 1333 DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQPAN 1390
D + ST L I+ + SP+ F N +TV+ + + ++ ++ +
Sbjct: 722 DGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEAKD 774
Query: 1391 TPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--GT- 1439
L + I F G + + + LD E Q + VE D GT
Sbjct: 775 VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM 834
Query: 1440 --NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTV 1497
+A V +K D ND P FS+ Y ++ D + T I + A D D + V
Sbjct: 835 PPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 892
Query: 1498 HSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVI 1553
+D + F ++ +G + T L+ E L ++ D P + A V
Sbjct: 893 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 952
Query: 1554 VNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGN 1612
+ V + P FT Y V E A G+ V ++A N ++Y+I +GN +
Sbjct: 953 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1007
Query: 1613 MFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTMSD 1665
F I + G+I + D T +VL ++ + + P S TA V I + +
Sbjct: 1008 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1067
Query: 1666 NSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGIFT 1715
N P F K Y V+E+ + TSV+ + A + T +I +K+G F
Sbjct: 1068 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FV 1125
Query: 1716 INPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
+ Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1126 VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
Score = 200 bits (509), Expect = 2e-50
Identities = 243/958 (25%), Positives = 393/958 (41%), Gaps = 132/958 (13%)
Query: 2771 LDRETSPAFHFKVAATIPLDK-VDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPV 2829
LDR+ H V ++K V + +V I V D NDN P F+ SY + E PV
Sbjct: 103 LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPV 162
Query: 2830 GTKL-----TQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNID-SNTGWISTLKDLDH 2883
GT + A D+D G NGQ+ Y + + + F I TG I K L++
Sbjct: 163 GTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 222
Query: 2884 ETDPTFTFSVVASDLGEAFS--LSSTALVSVRVTDINDNAPVFAQEV------------Y 2929
E + + A+D + + ++T ++V V D +D P+F V Y
Sbjct: 223 EDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTY 282
Query: 2930 RGNVKESDPPGEVVAVLSTWDRDTSDVNRQVS---------YHITGGNPRG--RFALGLV 2978
+ + E P E+ ++ T D +R + Y I G P RF +
Sbjct: 283 QAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF-FHMH 341
Query: 2979 QSEWKVYVKRPLDREEQDIYFLNITATDG---LFVTQAMVEVSVSDVNDNSPVCDQVAYT 3035
++ + P++R+ + L I A A + + + D N+ SP +Y
Sbjct: 342 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQ 401
Query: 3036 ALLPEDIPSNKII---------LKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
+ E P I L++ A D DI L+ + + F ++G +
Sbjct: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITR 461
Query: 3087 TLALL---DRERIPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYEN 3143
L LL DRE Y+ A DG +++ + D NDN P F Y+ VY +
Sbjct: 462 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTD 521
Query: 3144 TATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSI----------------------- 3180
+ ++ AVD D G N ++ Y + A G F I
Sbjct: 522 MRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYAL 581
Query: 3181 -----------DSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDI 3229
+ S+GI+ L + LDRE Y + + A+D P +S TV I V D+
Sbjct: 582 TVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDG--TSTATVNIVVTDV 639
Query: 3230 NDNPPVFERRDYL---VTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKI 3286
NDN PVF+ YL ++V E+ + V V AT D G N ++ Y + GN F+I
Sbjct: 640 NDNAPVFD--PYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI 694
Query: 3287 NPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVY 3346
G I + L+ E+ + LVV A DG + T+ I + D++DN P F+ Y
Sbjct: 695 T-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 753
Query: 3347 SAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDR 3406
+ ++ E+ G +++ + A+DVD N + + I + + + F + P G + + + LD
Sbjct: 754 TVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDY 811
Query: 3407 E----RVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVG 3462
E + + + LV+A D ATV + + D+ND PVF+ Y ++ + G
Sbjct: 812 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKG 871
Query: 3463 TSILQLVVTDRDSFHNGPPFSFSILSGNEEEEF--------VLDPHGILRSAVVFQHTES 3514
T I + D D G P S + ++ +F V + G + + V +
Sbjct: 872 TPITTVYAEDADP--PGLPAS-RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 928
Query: 3515 LEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFP-------- 3566
+ L V A D G+P S +++ V+ P EI T E+ P
Sbjct: 929 TIFKLVVVAFDDGEPVMSSSATVKILVLH---------PGEIPRFTQEEYRPPPVSELAT 979
Query: 3567 -GGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNSHDGKIIALGGLD---SGKYVLNV 3620
G ++G I A + V + +E+ + F +N+ G I G LD YVL V
Sbjct: 980 KGTMVGVISAAAINQSIVYSIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRV 1036
Score = 197 bits (501), Expect = 2e-49
Identities = 273/1130 (24%), Positives = 474/1130 (41%), Gaps = 174/1130 (15%)
Query: 1047 AVVGSVKENSRIGTSVLQ-VTARDEDSGRDGEIQYSIRDGSGLGRFS--IDDESGVITAA 1103
A + ++ E SR GT ++ + + G D I+ S++D + + +
Sbjct: 41 ATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTG 100
Query: 1104 DILDRE---TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMEN 1160
+LDR+ + S + V ++ V + EV I V D NDN+P YY V E
Sbjct: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESYYATVNEL 159
Query: 1161 SPKDVSVI-----QIQAEDPDSSSNEKLTYRITSGNPQN------FFAINIKTGLITTTS 1209
+P ++ A D D N ++ Y + NP + F + TG I
Sbjct: 160 TPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
Query: 1210 RKLDREQQAEHFLEVTVTDGGPSPKQ---STIWVVVQVLDENDNKPQFPEKV-------- 1258
R L+ E + +F+ + D + + +T + V VLD +D P F V
Sbjct: 219 R-LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1259 ----YQIKLPERDRKKRGEPIY-----RAFAFDRDEGPNAE---ISYSIVDGN--DDGKF 1304
YQ +PE + PI +A DR+ P ++ I YSI+ G D +F
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1305 F-IDPKTGMVSSRKQFTAG---SYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPL 1360
F + P+T +S + +D++ DNG P + A LHIE + + SP
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF-AGLHIEILDENNQSPY-- 394
Query: 1361 TFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAE--------KGV 1412
F P Y ++ES V + +PL + + + D E V
Sbjct: 395 -FTMPSYQGYILESAPVGATIS--DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 451
Query: 1413 GTIV---------IAKPLDAEQRSIYNMSVEVTDGTNVAVTQVF-IKVLDNNDNGPEFSQ 1462
T+ + +P+D E++ Y S+ DG + + I+V+D NDN P F +
Sbjct: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 511
Query: 1463 PNYDVTISEDVLPDTEILQIEATDRDE--KHKLSY-------------------TVHSSI 1501
+YDV + D+ P ++Q+ A D DE +++Y T+ +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGV 571
Query: 1502 DSISMRKFRI-----------DPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLA 1550
+ I R + + + STG+L + LD E+ D++IL I D P + A
Sbjct: 572 EMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGR-PDGTSTA 630
Query: 1551 RVIVNVEDANDHSPYFTNPL-YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGN 1609
V + V D ND++P F L SV E A + V QV A D D G N ++ Y++ GN
Sbjct: 631 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GN 687
Query: 1610 TGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHP 1669
N+F+I I T K + + L + TD P +T + I V D++ P
Sbjct: 688 FNNLFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSP 746
Query: 1670 KFIHKDYQAEVNENVDIGTSVILISAIS---QSTLIYEVKDGDINGIFTINPYSGVITTQ 1726
F + Y V EN+ GT+++ I A + + Y ++ ++ F ++P++G ++
Sbjct: 747 VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLL 806
Query: 1727 KALDYE----RTSSYQLIIQATNMAGM--ASNATVNIQIVDENDNAPVFLFSQYSGSLSE 1780
++LDYE + +S +++A ++ G ATV + + D ND PVF Y G ++
Sbjct: 807 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 866
Query: 1781 AAPINSIVRSLDNSPL-VIRATDAD-----SNRNALLVYQIVESTAKKFFTVDSSTGAIR 1834
A + +P+ + A DAD ++R V + F V+ +G +
Sbjct: 867 DA--------VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVI 918
Query: 1835 TIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNI-------EVTDVNDNPPVFTQAV 1887
T NL+ E F V D G P +++ + V++ + T PP ++
Sbjct: 919 TRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE-- 976
Query: 1888 FETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTIKN--N 1944
+ T VGV +SA + + + YS++ G+ D F I++ +GV+ + +
Sbjct: 977 ---LATKGTMVGV----ISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1025
Query: 1945 NLSKDHYMLIVKVSDGKFY----------STSMVTIMVKEAMDSGLHFTQSFYSTSISEN 1994
++ Y+L V+ + +T+ V I +++ + F + FY +SE+
Sbjct: 1026 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1085
Query: 1995 NTNITKVAIVNAVGNRLN--EPLKYSILNPGNK-----FKIKSTSGVIQT 2037
T V V A + Y ++ P K F +++ +G+I+T
Sbjct: 1086 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1135
Score = 196 bits (499), Expect = 3e-49
Identities = 271/1127 (24%), Positives = 445/1127 (39%), Gaps = 205/1127 (18%)
Query: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Query: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 373 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 402
Query: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Y L + + DS + ++ L KD +++ D
Sbjct: 403 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 439
Query: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
LH + Y++ + T IT+ T
Sbjct: 440 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 465
Query: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 466 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
Query: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNV----------------- 2139
PG + Q+TA+D D+G NGE+TY +L G F IN +G +
Sbjct: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 582
Query: 2140 -----------------ILKEAFNSDLSNIEYGVTILAKDGGKPSLST-SVELPITIVNK 2181
L +A + + S Y + I A DG ST +V + +T VN
Sbjct: 583 VQAADNAPPAERSTGILTLGKALDRE-STDRYILIITASDGRPDGTSTATVNIVVTDVND 641
Query: 2182 AMPVFDK--PFYTASVNEDIRMNTPILSINATSPEG--QGIIYIIIDGDPFKQFNIDFDT 2237
PVFD P + V E+ N + + AT P+ G ++ + G+ F I +
Sbjct: 642 NAPVFDPYLPRNLSVVEEE--ANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNG 698
Query: 2238 GVLKVVSPLDYEVTSAYKLTIRASDALTGAR-AEVTVDLLVNDVNDNPPIFDQPTYNTTL 2296
+ V L+ EV Y+L + A+D R + +T+ + V D++DN P+F TY +
Sbjct: 699 SIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 757
Query: 2297 SEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHEL 2356
E GT +LQ+ + D D N V Y+I +F + +G + R LD+E
Sbjct: 758 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEA 813
Query: 2357 V----QHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHF 2412
T V + D V + + D+ND PPVF++ IY+ V+ A +G
Sbjct: 814 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 873
Query: 2413 VTCVQASDADSSDF--DRLEY---SILSGNDRTSFLMDSKSG-VITLSNHRKQRMEPLYS 2466
+T V A DAD R+ Y + + F ++ SG VIT N ++
Sbjct: 874 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 933
Query: 2467 LNVSVSDG--LFTSTAQVHIRVLGANLYSPAFSQSTY-VAEVRENVAAGTKVIHVRATDG 2523
+ V+ DG + +S+A V I VL P F+Q Y V E GT V + A
Sbjct: 934 VVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 990
Query: 2524 DPGTYGQISYAIINDFAKDRFLIDS-NGQVITTERLDRENPLE-------GDVSIFVRAL 2575
I Y+I++ +D F I++ G + LD E + + + L
Sbjct: 991 --AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1048
Query: 2576 DGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRI 2635
++ V + + DEN++ P F Y V D V +V+A D D G S +
Sbjct: 1049 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1108
Query: 2636 TYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVD 2682
Y L + ++ G + T F+ ++ + F V A D
Sbjct: 1109 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1155
Score = 195 bits (495), Expect = 1e-48
Identities = 287/1166 (24%), Positives = 472/1166 (40%), Gaps = 158/1166 (13%)
Query: 2303 GTPVLQVVSIDADSENNK-MVHYQIVQDTY------------NSTDYFHIDSSSGLIL-- 2347
G P +V+ID +S N +V +++ T ++ DY+ + +L
Sbjct: 37 GGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFL 96
Query: 2348 --TARMLDHEL---VQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESY 2402
T R+LD + + ++V+ I+ ++ V I + D NDN P F Y +
Sbjct: 97 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHE-VRIVVRDRNDNSPTFKHESYYAT 155
Query: 2403 VSELAPRGHFVTCVQASDADSSDFD-----RLEYSI------------------LSGN-- 2437
V+EL P G + + D ++D D ++EY I L+GN
Sbjct: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
Query: 2438 --DRTSFLMDSKSGVITLSNHRKQ----RMEPLYSLNVSVSDG-----LFTSTAQV-HIR 2485
R ++ ++ VI +N R Q R +L V V DG +F V + R
Sbjct: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
Query: 2486 VLGANLYSPAFSQSTYVAE-----VRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFA 2540
Y A + E V + A + +++ PG I D+
Sbjct: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Query: 2541 KDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQF 2600
+ + ++ E ++R+ + D+ I +G F + + ++DEN+ +P F
Sbjct: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
Query: 2601 MTVEYRASVRADVGRGHLVT---------QVQAIDPD--DGANSRITYSLYSEASVSVAD 2649
Y+ + G ++ ++ A+D D D + + L SV
Sbjct: 396 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVT 455
Query: 2650 LLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFT 2709
I ++ ++ + +F + A DG + + V I V+ P+F
Sbjct: 456 QTGI---TRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFP 510
Query: 2710 QSQYSFTIAEDTAIGSTVDTLRILPSQ-----NVWFSTVNGERPE---NNKGGIFVI--- 2758
+ Y + D G +V L + + + + + G + + N G+ I
Sbjct: 511 EISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG 570
Query: 2759 ----------------------EQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVF 2796
E+ TG + L K LDRE++ + + A+ + D
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD--GRPDGTS 628
Query: 2797 TVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSD 2856
T V+I V D+NDN PVF+ + + + QV+A D D G NGQV YSL +
Sbjct: 629 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 688
Query: 2857 SQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTD 2916
+ F I SN G I T L+ E + VVA+D G ST ++++V D
Sbjct: 689 N------NLFRITSN-GSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLD 740
Query: 2917 INDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALG 2976
I+DN+PVF Y V+E+ P G + + D D+ VSY I + FAL
Sbjct: 741 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALH 797
Query: 2977 LVQSEWKVYVKRPLDRE-----EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSP 3027
E + + R LD E E I FL + A D ++ T A V V V D+ND P
Sbjct: 798 PFTGE--LSLLRSLDYEAFPDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPP 853
Query: 3028 VCDQVAYTALLPEDIPSNKIILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPE 3081
V + Y ++ D I V A+DAD +RY + + S F ++ +
Sbjct: 854 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEED 913
Query: 3082 SGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCV 3140
SG + T L+ E ++ L+ A D G S+ + IL P F+ + Y
Sbjct: 914 SGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPP 973
Query: 3141 YENTATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQS 3199
ATK + V + IN+ +VYS+ + + F I++ +G+I + PLD E ++
Sbjct: 974 VSELATKGTMVGVISA---AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1030
Query: 3200 SYNISVRATD------QSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGT 3253
SY + V+A S S+ V I + D N++PPVF+++ Y+ V ED T
Sbjct: 1031 SYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFT 1090
Query: 3254 QVLAVFATSKDIGTNAEITY-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLV 3310
VL V AT KD G + + Y LI ++GK F + TG I + + F
Sbjct: 1091 SVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQ 1150
Query: 3311 VEAKDGGTPALSAVATVNINLTDVND 3336
V A D LS A V +++ + D
Sbjct: 1151 VIATDDYGKGLSGKADVLVSVVNQLD 1176
Score = 194 bits (492), Expect = 2e-48
Identities = 287/1139 (25%), Positives = 455/1139 (39%), Gaps = 184/1139 (16%)
Query: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 249
Query: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TY---------------AVVT--VDDLDD 292
L V + ++ P VP + + P TY +VT + +D
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
N + S SI+ G P D E + E D F ++L ++
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 366
Query: 347 A-KDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
A +D G P A ++I + F Y I E +P G
Sbjct: 367 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
Query: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 484 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
Query: 507 ITYSIASLNLLPFVINQFTGVISTT----------------------------------E 532
ITY I F+IN+ TG+I+ +
Sbjct: 544 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGK 603
Query: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 604 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 660
Query: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
+ V A D D + GN F + + + K N +++ + L
Sbjct: 661 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 717
Query: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
+ ATDG +H + S+ + LA K+L
Sbjct: 718 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 739
Query: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 740 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 792
Query: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 793 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 852
Query: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 853 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 911
Query: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 912 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 968
Query: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 969 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1024
Query: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 1025 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1082
Query: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1083 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1142
Query: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1143 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1199
Score = 172 bits (437), Expect = 5e-42
Identities = 260/1106 (23%), Positives = 461/1106 (41%), Gaps = 181/1106 (16%)
Query: 998 LDYEKQQ-FYNLTVRAKDKGRPVSLSSVS--------------FVEVEVVDVNENLHTPY 1042
+D KQ F N T R D+ P+++ S+ + EV +V + N ++P
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPT 146
Query: 1043 FPDFAVVGSVKENSRIGTSVL-----QVTARDEDSGRDGEIQYSIR----DGSGLGRFSI 1093
F + +V E + +GT++ A D D G +G+I+Y I+ D + F I
Sbjct: 147 FKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI 206
Query: 1094 DDE-SGVITAADILDRETMGSYWLTVYATDRGV---VPLYSTIEVYIEVEDVNDNAPL-- 1147
+G I L+ E Y++ + A DR +T + ++V D +D P+
Sbjct: 207 PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFL 266
Query: 1148 ---------TSEPIYYPVVMEN--SPKDVSVI----QIQAEDPDS-----SSNEKLTYRI 1187
P+ Y + +P++++ I IQA D D S + Y I
Sbjct: 267 PCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 326
Query: 1188 TSGNPQN---FFAINIKTG---LITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVV 1241
G P++ FF ++ +T L+ +R D Q+ + ++ +G P P + + +
Sbjct: 327 LVGTPEDYPRFFHMHPRTAELSLLEPVNR--DFHQKFDLVIKAEQDNGHPLPAFAGLHI- 383
Query: 1242 VQVLDENDNKPQFPEKVYQIKLPER--------DRKKRGEPIYRAFAFDRD--EGPNAEI 1291
++LDEN+ P F YQ + E D P+ R A D+D + + E+
Sbjct: 384 -EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPEL 441
Query: 1292 SYSIVDGNDDGKFFIDPKTGMVS--------SRKQFTAGSYDILTIKAVDNGRPQKSSTA 1343
+ ND F +TG+ R++ ++ I V Q+S
Sbjct: 442 HLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV-----QESEPV 493
Query: 1344 RLHIEWIKKPPPSPIPLTFDEPFYNFTVME-SDRVTEIVGVVSVQPANTPLWFDIV---G 1399
++I+ + +P Y +T M D V ++ V + + +N + ++I+
Sbjct: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
Query: 1400 GNF------------------------------DSAFDAEKGVGTIVIAKPLDAEQRSIY 1429
G+F D+A AE+ G + + K LD E Y
Sbjct: 554 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRY 613
Query: 1430 NMSVEVTDGT--NVAVTQVFIKVLDNNDNGPEFSQ--PNYDVTISEDVLPDTEILQIEAT 1485
+ + +DG + V I V D NDN P F P + E+ + + Q++AT
Sbjct: 614 ILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKAT 671
Query: 1486 DRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPY 1545
D D ++ VH S+ + + FRI S G +YTA +L+ E +D + L ++ D
Sbjct: 672 DPDAG--INGQVHYSLGNFN-NLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHP 727
Query: 1546 RRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTI 1605
R + + + V D +D+SP FTN Y V E+ G+ +LQ+ A D D G N Y I
Sbjct: 728 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVS--YRI 785
Query: 1606 EAGNTGNMFKIEPVLGIITICKE------PDMTTMGQFVLSIKVTDQGSPPMSATAIVRI 1659
+ + F + P G +++ + PD F++ PP AT V +
Sbjct: 786 RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT--VTV 843
Query: 1660 SVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISA-------ISQSTLIYEVKDGDI-- 1710
V ++ P F + Y+ V + GT + + A + S + Y V D
Sbjct: 844 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 903
Query: 1711 -NGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAP 1767
IF + SG + T+ L+ E T+ ++L++ A + M+S+ATV I ++ + P
Sbjct: 904 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 962
Query: 1768 VFLFSQY-SGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTV 1826
F +Y +SE A ++V + + + N +VY IV + F +
Sbjct: 963 RFTQEEYRPPPVSELATKGTMVGVISAAAI-----------NQSIVYSIVSGNEEDTFGI 1011
Query: 1827 DSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQL------TAESPVEVNIEVTDVNDNP 1880
++ TG I LD+ET + V DS L + + +V IE+ D N++P
Sbjct: 1012 NNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHP 1070
Query: 1881 PVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLM-----EGSLDHFLIDSN 1935
PVF + + + + VL+V ATD D+ + Y L+ EG + F++++
Sbjct: 1071 PVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK-EGFVVETY 1129
Query: 1936 SGVL--TIKNNNLSKDHYMLIVKVSD 1959
+G++ + +N+ + ++ V +D
Sbjct: 1130 TGLIKTAMLFHNMRRSYFKFQVIATD 1155
Score = 160 bits (404), Expect = 4e-38
Identities = 236/989 (23%), Positives = 405/989 (40%), Gaps = 147/989 (14%)
Query: 1413 GTIVIAKPLDAEQRSIYNMSVEVTDGTN------VAVTQVFIKVLDNNDNGPEFSQ---- 1462
G IV+ K L+ E ++ Y + ++ D T + + VLD +D GP F
Sbjct: 212 GNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLV 271
Query: 1463 PN--------YDVTISE-----DVLPDTEILQIEATDRD-------EKHKLSYTVHSSID 1502
PN Y I E ++ P I+A D+D ++ + Y++
Sbjct: 272 PNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTP 331
Query: 1503 SISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDH 1562
R F + P T L E ++ + K L I A + + + D N+
Sbjct: 332 EDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQ 391
Query: 1563 SPYFTNPLYEASVFESAALGSAV---------LQVTALDKDKGENAELIYTIEAGNTGNM 1613
SPYFT P Y+ + ESA +G+ + L++ ALDKD + + + + ++
Sbjct: 392 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 451
Query: 1614 FKIEP--VLGIITICKEPDMTTMGQFVLSIKVTD--QGSPPMSATAIVRISVTMSDNSHP 1669
F + + +T+ + D + SI D Q S P+ IV I V ++++ P
Sbjct: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTP 507
Query: 1670 KFIHKDYQAEVNENVDIGTSVILISAI-----SQSTLIYEV---KDGDI-----NGIFTI 1716
F Y V ++ G SVI ++A+ S + YE+ GD G+ TI
Sbjct: 508 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITI 567
Query: 1717 NP-------------------------YSGVITTQKALDYERTSSYQLIIQATN-MAGMA 1750
P +G++T KALD E T Y LII A++
Sbjct: 568 APGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGT 627
Query: 1751 SNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLV--IRATDADSNRN 1808
S ATVNI + D NDNAPVF P N V + + V ++ATD D+ N
Sbjct: 628 STATVNIVVTDVNDNAPVF---------DPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 678
Query: 1809 ALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVE 1868
+ Y + F + +S G+I T L+ E ++ V D S +
Sbjct: 679 GQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH--PRHSTLT 733
Query: 1869 VNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLD 1928
+ I+V D++DN PVFT + + ++ G +L++ A D D + ++Y + +
Sbjct: 734 LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD--LGANVSYRIRSPEVK 791
Query: 1929 HFL-IDSNSGVLTIKNN----NLSKDHYMLIVKVSDGKFYST-----SMVTIMVKEAMDS 1978
HF + +G L++ + + V Y T + VT++VK+ D
Sbjct: 792 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 851
Query: 1979 GLHFTQSFYSTSISEN---NTNITKVAIVNAVGNRL-NEPLKYSILN-----PGNKFKIK 2029
F++ Y ++ + T IT V +A L ++Y + + P + F+++
Sbjct: 852 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 911
Query: 2030 STSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPY 2089
SG + T V + E +++LVV A + + + + V++ + + P F Y
Sbjct: 912 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 969
Query: 2090 Y-AAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY--VLQDDYGHFEINPNSGNVILK---- 2142
V A GT++ ++A N + Y V ++ F IN +G + +
Sbjct: 970 RPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1025
Query: 2143 -EAFNSDLSNIEY-GVTILAKDGGKPSLSTSVELPITI--VNKAMPVFDKPFYTASVNED 2198
E S + ++ + ++ + PS S + ++ I I N PVF K FY V+ED
Sbjct: 1026 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1085
Query: 2199 IRMNTPILSINATSPE--GQGIIYIIIDGDPFKQ----FNIDFDTGVLKVVSPLDYEVTS 2252
RM T +L + AT + ++ + P K+ F ++ TG++K S
Sbjct: 1086 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRS 1145
Query: 2253 AYKLTIRASDALTGARAEVTVDLLVNDVN 2281
+K + A+D G D+LV+ VN
Sbjct: 1146 YFKFQVIATDDY-GKGLSGKADVLVSVVN 1173
Score = 159 bits (401), Expect = 8e-38
Identities = 211/908 (23%), Positives = 384/908 (42%), Gaps = 139/908 (15%)
Query: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
Query: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
Query: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
Query: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWL-----------NEYKI 326
P +V+ T D D+G+NGEI + I+ G D F + K + Y +
Sbjct: 524 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYAL 581
Query: 327 KER------------------KQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPT 368
+ K +D ES Y L + A D G P S +
Sbjct: 582 TVQAADNAPPAERSTGILTLGKALDRESTD-RYILIITASD-GRPDGTSTATVNIVVTDV 639
Query: 369 RDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPGEDAVYFKINPRSG 427
D P+ ++S+ E V + P+ I+ + S G F+I +G
Sbjct: 640 NDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNG 698
Query: 428 LIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHTPEFQQPLYDAYVN 482
I TA LN ++ Y+L V +G + + + I + D +D++P F Y V
Sbjct: 699 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 758
Query: 483 ESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVISTTEELDFESSPE 541
E++P GT++L + A D D G N ++Y I S + F ++ FTG +S LD+E+ P+
Sbjct: 759 ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 816
Query: 542 ---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHI 597
F+V A D +G+ VT+ + ++ND P+F K +G+++ D G I
Sbjct: 817 QEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 874
Query: 598 TAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRI 653
T V A D D L V+Y++ +++ F Y + + ++++ +G R+
Sbjct: 875 TTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-------SGRVITRV 921
Query: 654 TATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFL 713
+ +P +I K+ +F E ++ K+L+ L G +
Sbjct: 922 NLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV---------LHPGEI 961
Query: 714 DFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSC 773
P F + V E G + I A + N ++++I GN +
Sbjct: 962 ---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDT 1008
Query: 774 FNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSSWRLLTINVEDAND 826
F I+ TG + V P+D E Y+ L + + +L P KS+ + I ++D N+
Sbjct: 1009 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1068
Query: 827 NSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-----TDTQQFAINS 881
+ PVF + Y + E + + T +++V+A DKD G+ + Y ++ + F + +
Sbjct: 1069 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1128
Query: 882 STGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSY 941
TG++ A ++ + ++ A D G + V + V + +P +
Sbjct: 1129 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTL 1188
Query: 942 SVKVLEDL 949
K +EDL
Sbjct: 1189 VEKKIEDL 1196
Score = 136 bits (343), Expect = 4e-31
Identities = 236/1046 (22%), Positives = 411/1046 (39%), Gaps = 209/1046 (19%)
Query: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 220 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 279
Query: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
TY I E TP + VT A D D G Y + F
Sbjct: 280 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 339
Query: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 340 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 392
Query: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 393 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 449
Query: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 450 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 501
Query: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 502 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 557
Query: 422 INPRSGLIVTARPLNTVKKEVYKLEVT--------------------------------- 448
IN +GLI A + + Y L V
Sbjct: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILII 617
Query: 449 -----NKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASD 498
+G A V I + D ND+ P++D Y+ ++ V V V A+D
Sbjct: 618 TASDGRPDGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATD 672
Query: 499 KDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRH 558
D G NG + YS+ + N L + + G I T +L+ E + Y +V A+D G+ +
Sbjct: 673 PDAGINGQVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPR 728
Query: 559 ESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISG 618
S + + I++ +++DNSP+F ++ + P G I + A D+D V Y+I S
Sbjct: 729 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSP 788
Query: 619 NELGFFYLNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKV 676
FF L+P +G L L +SL + + + A D P ++V+
Sbjct: 789 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---- 844
Query: 677 SSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVK 736
+N P F K + V
Sbjct: 845 --------------------------------------VKDMNDYPPVFSKRIYKGM-VA 865
Query: 737 EDLPVGANILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDR 791
D G I + A DAD +V + + D S F ++ ++G++ + ++
Sbjct: 866 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 925
Query: 792 EHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGT 848
E T ++ L + +D G P SS + I V + P F Q+ Y V+ L + G
Sbjct: 926 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMV 984
Query: 849 EIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEA 906
+I A N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A
Sbjct: 985 GVISAAA------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1038
Query: 907 RDKAESGQQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLET 960
D E V T KV+++ D N+ P F Y V ED + T + ++
Sbjct: 1039 -DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1097
Query: 961 HDPDLGLGGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD-- 1014
D D G + Y L + + F ++ +G I+ + ++ ++ V A D
Sbjct: 1098 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1157
Query: 1015 -KG----RPVSLSSVSFVEVEVVDVN 1035
KG V +S V+ ++++V+ N
Sbjct: 1158 GKGLSGKADVLVSVVNQLDMQVIVSN 1183
Score = 52.0 bits (123), Expect = 1e-05
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 987 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1044
Query: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 1045 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1104
Query: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 1105 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1159
Query: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 1160 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1198
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 171,408,624
Number of Sequences: 37866
Number of extensions: 8081500
Number of successful extensions: 62876
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 312
Number of HSP's successfully gapped in prelim test: 209
Number of HSP's that attempted gapping in prelim test: 18093
Number of HSP's gapped (non-prelim): 6897
length of query: 4557
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4434
effective length of database: 13,590,000
effective search space: 60258060000
effective search space used: 60258060000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.