Search of human proteins with 148539870

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
         (954 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]          1947   0.0  
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]          1928   0.0  
gi|153085395 histone deacetylase 4 [Homo sapiens]                     806   0.0  
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]            690   0.0  
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]            690   0.0  
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]            653   0.0  
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]            652   0.0  
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]            629   e-180
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]            417   e-116
gi|13128864 histone deacetylase 6 [Homo sapiens]                      285   1e-76
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]           232   1e-60
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]          197   3e-50
gi|13128860 histone deacetylase 1 [Homo sapiens]                      108   2e-23
gi|116284376 histone deacetylase 2 [Homo sapiens]                     104   3e-22
gi|8923769 histone deacetylase 8 [Homo sapiens]                        94   6e-19
gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]              94   6e-19
gi|13128862 histone deacetylase 3 [Homo sapiens]                       86   2e-16
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    64   5e-10
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]           59   3e-08
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]           57   8e-08
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    56   1e-07
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   54   7e-07
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   54   7e-07
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   54   7e-07
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    54   7e-07
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         52   3e-06
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    50   1e-05
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...    50   1e-05
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom...    49   2e-05
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom...    49   2e-05

>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
          Length = 954

 Score = 1947 bits (5043), Expect = 0.0
 Identities = 954/954 (100%), Positives = 954/954 (100%)

Query: 1   MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA 60
           MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA
Sbjct: 1   MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA 60

Query: 61  LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120
           LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA
Sbjct: 61  LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120

Query: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP 180
           SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP
Sbjct: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP 180

Query: 181 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS 240
           SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS
Sbjct: 181 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS 240

Query: 241 SSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEA 300
           SSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEA
Sbjct: 241 SSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEA 300

Query: 301 GGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRS 360
           GGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRS
Sbjct: 301 GGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRS 360

Query: 361 EPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQ 420
           EPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQ
Sbjct: 361 EPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQ 420

Query: 421 VVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGH 480
           VVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGH
Sbjct: 421 VVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGH 480

Query: 481 RPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDN 540
           RPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDN
Sbjct: 481 RPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDN 540

Query: 541 SRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLK 600
           SRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLK
Sbjct: 541 SRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLK 600

Query: 601 LDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELK 660
           LDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELK
Sbjct: 601 LDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELK 660

Query: 661 NGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTF 720
           NGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTF
Sbjct: 661 NGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTF 720

Query: 721 YQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAF 780
           YQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAF
Sbjct: 721 YQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAF 780

Query: 781 RIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLA 840
           RIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLA
Sbjct: 781 RIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLA 840

Query: 841 LEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCM 900
           LEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCM
Sbjct: 841 LEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCM 900

Query: 901 QRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL 954
           QRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
Sbjct: 901 QRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL 954


>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
          Length = 991

 Score = 1928 bits (4995), Expect = 0.0
 Identities = 954/991 (96%), Positives = 954/991 (96%), Gaps = 37/991 (3%)

Query: 1   MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA 60
           MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA
Sbjct: 1   MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLA 60

Query: 61  LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120
           LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA
Sbjct: 61  LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120

Query: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP 180
           SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP
Sbjct: 121 SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLP 180

Query: 181 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS 240
           SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS
Sbjct: 181 SDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSS 240

Query: 241 SSTPASGCSSPNDSEHGPNPILGSE----------------------------------- 265
           SSTPASGCSSPNDSEHGPNPILGSE                                   
Sbjct: 241 SSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAP 300

Query: 266 --ADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL 323
             ADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL
Sbjct: 301 ARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPL 360

Query: 324 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL 383
           LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL
Sbjct: 361 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQL 420

Query: 384 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP 443
           KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP
Sbjct: 421 KTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAP 480

Query: 444 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS 503
           LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS
Sbjct: 481 LQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPAS 540

Query: 504 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR 563
           QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR
Sbjct: 541 QARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLR 600

Query: 564 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV 623
           SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV
Sbjct: 601 SQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGV 660

Query: 624 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF 683
           GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF
Sbjct: 661 GVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCF 720

Query: 684 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS 743
           FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS
Sbjct: 721 FNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS 780

Query: 744 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD 803
           GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD
Sbjct: 781 GAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFD 840

Query: 804 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG 863
           AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG
Sbjct: 841 AAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG 900

Query: 864 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE 923
           NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE
Sbjct: 901 NRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVE 960

Query: 924 AVTALASLSVGILAEDRPSEQLVEEEEPMNL 954
           AVTALASLSVGILAEDRPSEQLVEEEEPMNL
Sbjct: 961 AVTALASLSVGILAEDRPSEQLVEEEEPMNL 991


>gi|153085395 histone deacetylase 4 [Homo sapiens]
          Length = 1084

 Score =  806 bits (2081), Expect = 0.0
 Identities = 489/1006 (48%), Positives = 616/1006 (61%), Gaps = 133/1006 (13%)

Query: 59   LALQRPQRLHHHL-----FLAGLQQQRSVEPMR-LSMDTPMPELQVGPQEQELRQLLHKD 112
            L+ Q   +LH H+      LA   QQ  +E  R L       EL+   +EQ+L+QL +K+
Sbjct: 100  LSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKE 159

Query: 113  KSKRSAVASSVVKQKLAEVILKKQQAALERTVH---PNSPGIPYRTLE--PLETEGATRS 167
            K K SAVAS+ VK KL E +L K++A   R ++    + P   Y   +   L+     +S
Sbjct: 160  KGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQS 219

Query: 168  MLS-SFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPK-KSLERRKNPLLRKESAP--P 223
             +S S+  PV  +  D  + FPLRKT SEPNLKLR + K K  ERR +PLLR++  P   
Sbjct: 220  GVSTSYNHPVLGM-YDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVT 278

Query: 224  SLRRRPAETLGDSSPSSSSTPASGCSSPNDS------EHG-------------------- 257
            +L++RP +    +  + SS P SG SSPN+S      E+G                    
Sbjct: 279  ALKKRPLDV---TDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVA 335

Query: 258  ----------------PNPILG-----------SEADSDRRTHPTLGPRGPILGSPH-TP 289
                            PN  LG            + D++R T P L  R  +    H TP
Sbjct: 336  REGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTP 395

Query: 290  LFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGS 349
                  LE + G      LQ ++LL+   + APL+T  GLG LP H AQSL+  +R+S S
Sbjct: 396  YLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVT--GLGALPLH-AQSLVGADRVSPS 452

Query: 350  ----GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQ-----------VIKRSA 394
                  H PL RT+S PLP +A A       Q   + L+ H Q           +I + +
Sbjct: 453  IHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPS 512

Query: 395  KPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQ--------------PEARG 440
            +P+ +P      + E+L        +   D L  ++  H Q               EA  
Sbjct: 513  EPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEP 572

Query: 441  P---APLQQHP---------QVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQS 488
            P    P Q+ P         Q LL EQQR+       ++ +   +P++ GGHRPLSRAQS
Sbjct: 573  PREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQS 632

Query: 489  SPA-APASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHA 547
            SPA A   +S  EP ++ R             FTTGL+YD++MLKHQC+CG +S HPEHA
Sbjct: 633  SPASATFPVSVQEPPTKPR-------------FTTGLVYDTLMLKHQCTCGSSSSHPEHA 679

Query: 548  GRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLA 607
            GRIQSIWSRLQE GLR +CEC+RGRKA+LEELQ+VHSE H LLYGTNPL+R KLD+ KL 
Sbjct: 680  GRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLL 739

Query: 608  GLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVR 667
            G LA  +FV LPCGGVGVD+DTIWNE+HS+ AAR A G V +L FKVA+ ELKNGFAVVR
Sbjct: 740  GSLAS-VFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVR 798

Query: 668  PPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVL 727
            PPGHHA+ ST MGFC+FNSVA+A + LQQ+   SKILIVDWDVHHGNGTQQ FY DPSVL
Sbjct: 799  PPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVL 858

Query: 728  YISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPI 787
            Y+SLHR+DDGNFFPGSGA DEVG G G GFNVN+A+ GGLDPPMGD EYLAAFR VVMPI
Sbjct: 859  YMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPI 918

Query: 788  AREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDL 847
            A EF+PD+VLVS+GFDA EGHP PLGGY++SA+CFGY+T+QLM LAGG +VLALEGGHDL
Sbjct: 919  ASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDL 978

Query: 848  TAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCP 907
            TAICDASEACV+ALLGN +DPL E+  +Q+PN NA+RS+E V+ +HSKYW C+QR  S  
Sbjct: 979  TAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTA 1038

Query: 908  DSWVPRVPGADKEEVEAVTALASLSVGIL-AEDRPSEQLVEEEEPM 952
               +      + EE E VTA+ASLSVG+  AE RP E+ +EEE P+
Sbjct: 1039 GRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL 1084


>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
          Length = 1123

 Score =  690 bits (1780), Expect = 0.0
 Identities = 452/1092 (41%), Positives = 592/1092 (54%), Gaps = 199/1092 (18%)

Query: 34   GPQPQPMDLR---VGQRPPV--EPPPEPTLLALQRPQRL------------HHHL----- 71
            G  P P++LR   VG   P   E   +  LLAL++ Q+L            H HL     
Sbjct: 52   GGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHE 111

Query: 72   ------------FLAGLQQQ--------RSVEPMRLSMDTPMPELQVGPQEQELRQLLHK 111
                         LA  QQQ        + +E  R        EL+    EQ+L  L +K
Sbjct: 112  VQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNK 171

Query: 112  DKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSS 171
            +KSK SA+AS+ VK +L E +L K +        P   G+ +   +  +  GA  + L  
Sbjct: 172  EKSKESAIASTEVKLRLQEFLLSKSK-------EPTPGGLNHSLPQHPKCWGAHHASLDQ 224

Query: 172  FLPPVPSLPSDPPEH-------------FPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLR 217
              PP    P  PP +             FPLRKT SEPNLK+R + K+ + ERR +PLLR
Sbjct: 225  SSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLR 284

Query: 218  KESAP--PSLRRRPAETLG----------------DSSPSSS-STPASGC---------- 248
            ++      + ++R  E  G                 SSP+SS ST A             
Sbjct: 285  RKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPT 344

Query: 249  ------------SSPND-----SEHGPN-------------------PILGSEADSDRRT 272
                        SSPN      S   PN                   P L ++ +++R+ 
Sbjct: 345  EMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQA 404

Query: 273  HPTLGPRGPILGSPHTPLFLPH---GLEPEAGGTL---PSRLQPILLLDPSGSHAPLLTV 326
              +L   G + G   +   +P    G+  E  G+     S LQ +LLL+ +   + L+ V
Sbjct: 405  LQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAV 464

Query: 327  PGLGPLPFHFAQSLMTTERLSGS-GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLE---- 381
            P  G  P    + + T+ R  G    H PLSRT+S PLP S  A       Q   +    
Sbjct: 465  PLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEK 524

Query: 382  QLKTHVQVIKRSAKPSEKPRLRQIPSAEDLET------------------DGGGPGQVVD 423
            Q +  +Q+ K   K  E PR       E  E                   +G    +   
Sbjct: 525  QKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQ 584

Query: 424  DGLEHR-ELGHGQPEA--------RGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVL-- 472
            + LE   E   G+ E          G +  ++ P +    ++  AG     S    +   
Sbjct: 585  EDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDL----EEPGAGYKKLFSDAQPLQPL 640

Query: 473  ------LPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIY 526
                  L LA   H+ L R QSSPAAP  + +P            + P + L FTTG++Y
Sbjct: 641  QVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPP-----------DQPVKHL-FTTGVVY 688

Query: 527  DSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSER 586
            D+ MLKHQC CG+   HPEHAGRIQSIWSRLQE GL S+CE +RGRKA+L+E+Q+VHSE 
Sbjct: 689  DTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEY 748

Query: 587  HVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGS 646
            H LLYGT+PL+R KLD+ KL G ++Q+M+ +LPCGG+GVD+DT+WNE+HSS+A R A G 
Sbjct: 749  HTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGC 808

Query: 647  VTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIV 706
            + +LAFKVA+ ELKNGFA++RPPGHHA+ STAMGFCFFNSVAI  + LQQ+    K+LIV
Sbjct: 809  LLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIV 868

Query: 707  DWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGG 766
            DWD+HHGNGTQQ FY DPSVLYISLHR+D+GNFFPGSGA +EVG G G G+NVNVAW GG
Sbjct: 869  DWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGG 928

Query: 767  LDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMT 826
            +DPP+GD EYL AFR VVMPIA EFSPD+VLVSAGFDA EGH +PLGGY V+A+CFG++T
Sbjct: 929  VDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLT 988

Query: 827  QQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSL 886
            +QLM LAGG VVLALEGGHDLTAICDASEACV+ALL   + PL E   +QKPN+NA+ +L
Sbjct: 989  RQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATL 1048

Query: 887  EAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILA--------- 937
            E VI + SK+W C+Q+ A+     +      + EE E V+A+A LSVG            
Sbjct: 1049 EKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREH 1108

Query: 938  EDRPSEQLVEEE 949
              RP+E+ +E+E
Sbjct: 1109 SPRPAEEPMEQE 1120


>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
          Length = 1122

 Score =  690 bits (1780), Expect = 0.0
 Identities = 452/1092 (41%), Positives = 592/1092 (54%), Gaps = 199/1092 (18%)

Query: 34   GPQPQPMDLR---VGQRPPV--EPPPEPTLLALQRPQRL------------HHHL----- 71
            G  P P++LR   VG   P   E   +  LLAL++ Q+L            H HL     
Sbjct: 51   GGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHE 110

Query: 72   ------------FLAGLQQQ--------RSVEPMRLSMDTPMPELQVGPQEQELRQLLHK 111
                         LA  QQQ        + +E  R        EL+    EQ+L  L +K
Sbjct: 111  VQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNK 170

Query: 112  DKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSS 171
            +KSK SA+AS+ VK +L E +L K +        P   G+ +   +  +  GA  + L  
Sbjct: 171  EKSKESAIASTEVKLRLQEFLLSKSK-------EPTPGGLNHSLPQHPKCWGAHHASLDQ 223

Query: 172  FLPPVPSLPSDPPEH-------------FPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLR 217
              PP    P  PP +             FPLRKT SEPNLK+R + K+ + ERR +PLLR
Sbjct: 224  SSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLR 283

Query: 218  KESAP--PSLRRRPAETLG----------------DSSPSSS-STPASGC---------- 248
            ++      + ++R  E  G                 SSP+SS ST A             
Sbjct: 284  RKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPT 343

Query: 249  ------------SSPND-----SEHGPN-------------------PILGSEADSDRRT 272
                        SSPN      S   PN                   P L ++ +++R+ 
Sbjct: 344  EMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQA 403

Query: 273  HPTLGPRGPILGSPHTPLFLPH---GLEPEAGGTL---PSRLQPILLLDPSGSHAPLLTV 326
              +L   G + G   +   +P    G+  E  G+     S LQ +LLL+ +   + L+ V
Sbjct: 404  LQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAV 463

Query: 327  PGLGPLPFHFAQSLMTTERLSGS-GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLE---- 381
            P  G  P    + + T+ R  G    H PLSRT+S PLP S  A       Q   +    
Sbjct: 464  PLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEK 523

Query: 382  QLKTHVQVIKRSAKPSEKPRLRQIPSAEDLET------------------DGGGPGQVVD 423
            Q +  +Q+ K   K  E PR       E  E                   +G    +   
Sbjct: 524  QKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQ 583

Query: 424  DGLEHR-ELGHGQPEA--------RGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVL-- 472
            + LE   E   G+ E          G +  ++ P +    ++  AG     S    +   
Sbjct: 584  EDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDL----EEPGAGYKKLFSDAQPLQPL 639

Query: 473  ------LPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIY 526
                  L LA   H+ L R QSSPAAP  + +P            + P + L FTTG++Y
Sbjct: 640  QVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPP-----------DQPVKHL-FTTGVVY 687

Query: 527  DSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSER 586
            D+ MLKHQC CG+   HPEHAGRIQSIWSRLQE GL S+CE +RGRKA+L+E+Q+VHSE 
Sbjct: 688  DTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEY 747

Query: 587  HVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGS 646
            H LLYGT+PL+R KLD+ KL G ++Q+M+ +LPCGG+GVD+DT+WNE+HSS+A R A G 
Sbjct: 748  HTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGC 807

Query: 647  VTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIV 706
            + +LAFKVA+ ELKNGFA++RPPGHHA+ STAMGFCFFNSVAI  + LQQ+    K+LIV
Sbjct: 808  LLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIV 867

Query: 707  DWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGG 766
            DWD+HHGNGTQQ FY DPSVLYISLHR+D+GNFFPGSGA +EVG G G G+NVNVAW GG
Sbjct: 868  DWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGG 927

Query: 767  LDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMT 826
            +DPP+GD EYL AFR VVMPIA EFSPD+VLVSAGFDA EGH +PLGGY V+A+CFG++T
Sbjct: 928  VDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLT 987

Query: 827  QQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSL 886
            +QLM LAGG VVLALEGGHDLTAICDASEACV+ALL   + PL E   +QKPN+NA+ +L
Sbjct: 988  RQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATL 1047

Query: 887  EAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILA--------- 937
            E VI + SK+W C+Q+ A+     +      + EE E V+A+A LSVG            
Sbjct: 1048 EKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREH 1107

Query: 938  EDRPSEQLVEEE 949
              RP+E+ +E+E
Sbjct: 1108 SPRPAEEPMEQE 1119


>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
          Length = 1066

 Score =  653 bits (1684), Expect = 0.0
 Identities = 444/1015 (43%), Positives = 553/1015 (54%), Gaps = 147/1015 (14%)

Query: 59   LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115
            L  Q   +L  H+   LA  QQQ  +E   +L       E++   +EQ+L  L  KD+ +
Sbjct: 75   LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134

Query: 116  RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175
              AVAS+ VKQKL E +L K      +    N           L    A  + L    PP
Sbjct: 135  ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191

Query: 176  VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222
            +         +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +  
Sbjct: 192  LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251

Query: 223  PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEADSDR- 270
             S ++R  E     S  SSS+P SG SSPN+   G           P P         R 
Sbjct: 252  TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRI 309

Query: 271  ------------RTHPTLGPRGPILGSPHTPLFLPHG-------------------LEPE 299
                         T P+L      LG P  P  L                      L  +
Sbjct: 310  LIHEDSMNLLSLYTSPSLP--NITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQ 367

Query: 300  AGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSLMTT 343
             GG++P S   P + L+   P+ SH  LL    L            G +P H    L T 
Sbjct: 368  YGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATK 427

Query: 344  ERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ------V 389
            ER+S           H PL+RT+S PLP S  A        Q  LE+ K + Q      +
Sbjct: 428  ERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL 487

Query: 390  IKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH------ 428
            + +S +  ++P      + E+L+ D                      VDD L        
Sbjct: 488  LSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKV 547

Query: 429  RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HRPLS 484
            +E      E      ++   Q    +Q  L     R  S     L  +   G   HR +S
Sbjct: 548  KEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVS 607

Query: 485  RAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHP 544
            R  SSPAA      P PA    +   S          TG+ YD +MLKHQC CG+++ HP
Sbjct: 608  RTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNSTTHP 655

Query: 545  EHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNG 604
            EHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL   KLD  
Sbjct: 656  EHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPR 715

Query: 605  KLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFA 664
             L G  +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKNGFA
Sbjct: 716  ILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFA 775

Query: 665  VVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDP 724
            VVRPPGHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGTQQ FY DP
Sbjct: 776  VVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADP 835

Query: 725  SVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVV 784
            S+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR +V
Sbjct: 836  SILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIV 895

Query: 785  MPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGG 844
             P+A+EF PD+VLVSAGFDA EGH  PLGGY V+AKCFG++T+QLM LA G VVLALEGG
Sbjct: 896  KPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGG 955

Query: 845  HDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLA 904
            HDLTAICDASEACV ALLGN ++PL+E+   Q PN+NA+ SL+ +I + SKYW  ++ +A
Sbjct: 956  HDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVA 1015

Query: 905  SCPDSWVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEEEEP 951
                  VPR   + GA  +EE E V+ALASL+V +      ED  +     EEEP
Sbjct: 1016 ------VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEP 1064


>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
          Length = 1069

 Score =  652 bits (1683), Expect = 0.0
 Identities = 440/1010 (43%), Positives = 549/1010 (54%), Gaps = 144/1010 (14%)

Query: 61   LQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVA 120
            LQ   +L   L     QQ+   +  +L       E++   +EQ+L  L  KD+ +  AVA
Sbjct: 83   LQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVA 142

Query: 121  SSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVP--- 177
            S+ VKQKL E +L K      +    N           L    A  + L    PP+    
Sbjct: 143  STEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTS 199

Query: 178  -----SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAPPSLRR 227
                 +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +   S ++
Sbjct: 200  PSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKK 259

Query: 228  RPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEADSDR------ 270
            R  E     S  SSS+P SG SSPN+   G           P P         R      
Sbjct: 260  RMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHED 317

Query: 271  -------RTHPTLGPRGPILGSPHTPLFLPHG-------------------LEPEAGGTL 304
                    T P+L      LG P  P  L                      L  + GG++
Sbjct: 318  SMNLLSLYTSPSLP--NITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSI 375

Query: 305  P-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSLMTTERLSG 348
            P S   P + L+   P+ SH  LL    L            G +P H    L T ER+S 
Sbjct: 376  PASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISP 435

Query: 349  S-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ------VIKRSA 394
                      H PL+RT+S PLP S  A        Q  LE+ K + Q      ++ +S 
Sbjct: 436  GIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSI 495

Query: 395  KPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH------RELGH 433
            +  ++P      + E+L+ D                      VDD L        +E   
Sbjct: 496  EQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPV 555

Query: 434  GQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HRPLSRAQSS 489
               E      ++   Q    +Q  L     R  S     L  +   G   HR +SR  SS
Sbjct: 556  DSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 615

Query: 490  PAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGR 549
            PAA      P PA    +   S          TG+ YD +MLKHQC CG+++ HPEHAGR
Sbjct: 616  PAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNSTTHPEHAGR 663

Query: 550  IQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGL 609
            IQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL   KLD   L G 
Sbjct: 664  IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD 723

Query: 610  LAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPP 669
             +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKNGFAVVRPP
Sbjct: 724  DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP 783

Query: 670  GHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYI 729
            GHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGTQQ FY DPS+LYI
Sbjct: 784  GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI 843

Query: 730  SLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAR 789
            SLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR +V P+A+
Sbjct: 844  SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 903

Query: 790  EFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTA 849
            EF PD+VLVSAGFDA EGH  PLGGY V+AKCFG++T+QLM LA G VVLALEGGHDLTA
Sbjct: 904  EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 963

Query: 850  ICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDS 909
            ICDASEACV ALLGN ++PL+E+   Q PN+NA+ SL+ +I + SKYW  ++ +A     
Sbjct: 964  ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVA----- 1018

Query: 910  WVPR---VPGAD-KEEVEAVTALASLSVGI----LAEDRPSEQLVEEEEP 951
             VPR   + GA  +EE E V+ALASL+V +      ED  +     EEEP
Sbjct: 1019 -VPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEP 1067


>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
          Length = 1011

 Score =  629 bits (1623), Expect = e-180
 Identities = 419/950 (44%), Positives = 519/950 (54%), Gaps = 133/950 (14%)

Query: 59   LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115
            L  Q   +L  H+   LA  QQQ  +E   +L       E++   +EQ+L  L  KD+ +
Sbjct: 75   LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134

Query: 116  RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175
              AVAS+ VKQKL E +L K      +    N           L    A  + L    PP
Sbjct: 135  ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191

Query: 176  VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222
            +         +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +  
Sbjct: 192  LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251

Query: 223  PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEADSDR- 270
             S ++R  E     S  SSS+P SG SSPN+   G           P P         R 
Sbjct: 252  TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRI 309

Query: 271  ------------RTHPTLGPRGPILGSPHTPLFLPHG-------------------LEPE 299
                         T P+L      LG P  P  L                      L  +
Sbjct: 310  LIHEDSMNLLSLYTSPSLP--NITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQ 367

Query: 300  AGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSLMTT 343
             GG++P S   P + L+   P+ SH  LL    L            G +P H    L T 
Sbjct: 368  YGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATK 427

Query: 344  ERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ------V 389
            ER+S           H PL+RT+S PLP S  A        Q  LE+ K + Q      +
Sbjct: 428  ERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL 487

Query: 390  IKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH------ 428
            + +S +  ++P      + E+L+ D                      VDD L        
Sbjct: 488  LSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKV 547

Query: 429  RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HRPLS 484
            +E      E      ++   Q    +Q  L     R  S     L  +   G   HR +S
Sbjct: 548  KEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVS 607

Query: 485  RAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHP 544
            R  SSPAA      P PA    +   S          TG+ YD +MLKHQC CG+++ HP
Sbjct: 608  RTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNSTTHP 655

Query: 545  EHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNG 604
            EHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL   KLD  
Sbjct: 656  EHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPR 715

Query: 605  KLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFA 664
             L G  +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKNGFA
Sbjct: 716  ILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFA 775

Query: 665  VVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDP 724
            VVRPPGHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGTQQ FY DP
Sbjct: 776  VVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADP 835

Query: 725  SVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVV 784
            S+LYISLHR+D+GNFFPGSGA +EVG G GEG+N+N+AW GGLDPPMGD EYL AFR +V
Sbjct: 836  SILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIV 895

Query: 785  MPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGG 844
             P+A+EF PD+VLVSAGFDA EGH  PLGGY V+AKCFG++T+QLM LA G VVLALEGG
Sbjct: 896  KPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGG 955

Query: 845  HDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHS 894
            HDLTAICDASEACV ALLGN ++PL+E+   Q PN+NA+ SL+ +I + S
Sbjct: 956  HDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1005


>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
          Length = 879

 Score =  417 bits (1071), Expect = e-116
 Identities = 319/805 (39%), Positives = 399/805 (49%), Gaps = 133/805 (16%)

Query: 59  LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115
           L  Q   +L  H+   LA  QQQ  +E   +L       E++   +EQ+L  L  KD+ +
Sbjct: 75  LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134

Query: 116 RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175
             AVAS+ VKQKL E +L K      +    N           L    A  + L    PP
Sbjct: 135 ERAVASTEVKQKLQEFLLSKSAT---KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191

Query: 176 VP--------SLPS--DPPEHFPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLRKE--SAP 222
           +         +LP   D  + FPLRKT SEPNLK+R + K+ + ERR +PLLR++  +  
Sbjct: 192 LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251

Query: 223 PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEADSDR- 270
            S ++R  E     S  SSS+P SG SSPN+   G           P P         R 
Sbjct: 252 TSFKKRMFEVT--ESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRI 309

Query: 271 ------------RTHPTLGPRGPILGSPHTPLFLPHG-------------------LEPE 299
                        T P+L      LG P  P  L                      L  +
Sbjct: 310 LIHEDSMNLLSLYTSPSLP--NITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQ 367

Query: 300 AGGTLP-SRLQPILLLD---PSGSHAPLLTVPGL------------GPLPFHFAQSLMTT 343
            GG++P S   P + L+   P+ SH  LL    L            G +P H    L T 
Sbjct: 368 YGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATK 427

Query: 344 ERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPM-QPRLEQLKTHVQ------V 389
           ER+S           H PL+RT+S PLP S  A        Q  LE+ K + Q      +
Sbjct: 428 ERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKL 487

Query: 390 IKRSAKPSEKPRLRQIPSAEDLETDGG---------------GPGQVVDDGLEH------ 428
           + +S +  ++P      + E+L+ D                      VDD L        
Sbjct: 488 LSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKV 547

Query: 429 RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG-STGDTVLLPLAQGG---HRPLS 484
           +E      E      ++   Q    +Q  L     R  S     L  +   G   HR +S
Sbjct: 548 KEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVS 607

Query: 485 RAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHP 544
           R  SSPAA      P PA    +   S          TG+ YD +MLKHQC CG+++ HP
Sbjct: 608 RTHSSPAASV---LPHPAMDRPLQPGS---------ATGIAYDPLMLKHQCVCGNSTTHP 655

Query: 545 EHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNG 604
           EHAGRIQSIWSRLQE GL ++CE ++GRKASLEE+Q VHSE H LLYGTNPL   KLD  
Sbjct: 656 EHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPR 715

Query: 605 KLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFA 664
            L G  +Q+ F  LPCGG+GVD+DTIWNELHSS AAR A G V +LA KVAS ELKNGFA
Sbjct: 716 ILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFA 775

Query: 665 VVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDP 724
           VVRPPGHHA+ STAMGFCFFNSVAI  + L+ Q   SKILIVD DVHHGNGTQQ FY DP
Sbjct: 776 VVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADP 835

Query: 725 SVLYISLHRHDDGNFFPGSGAVDEV 749
           S+LYISLHR+D+GNFFPGSGA +EV
Sbjct: 836 SILYISLHRYDEGNFFPGSGAPNEV 860


>gi|13128864 histone deacetylase 6 [Homo sapiens]
          Length = 1215

 Score =  285 bits (730), Expect = 1e-76
 Identities = 174/380 (45%), Positives = 222/380 (58%), Gaps = 33/380 (8%)

Query: 522 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 581
           TGL+YD  M+ H C+  D S HPE   RI  I  RL+E GL  +C  L  R A+  EL +
Sbjct: 481 TGLVYDQNMMNH-CNLWD-SHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLT 538

Query: 582 VHSERHV-LLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAA 640
            HS  +V  L  T  +   +L                        + D+I+    +   A
Sbjct: 539 CHSAEYVGHLRATEKMKTRELHRESS-------------------NFDSIYICPSTFACA 579

Query: 641 RWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQS-K 699
           + A G+   L   V S E+ NG AVVRPPGHHA+   A GFCFFNSVA+A R  Q  S  
Sbjct: 580 QLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGH 639

Query: 700 ASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGF 757
           A +ILIVDWDVHHGNGTQ  F  DPSVLY+SLHR+D G FFP    GA  ++G  +G GF
Sbjct: 640 ALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGF 699

Query: 758 NVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHV 817
            VNVAW G   P MGD +YLAA+  +V+PIA EF+P+LVLVSAGFDAA G   PLGG  V
Sbjct: 700 TVNVAWNG---PRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGD--PLGGCQV 754

Query: 818 SAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQK 877
           S + + ++T  LM LA G ++L LEGG++LT+I ++  AC  +LLG   DP       + 
Sbjct: 755 SPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLG---DPPPLLTLPRP 811

Query: 878 PNLNAIRSLEAVIRVHSKYW 897
           P   A+ S+   I+VH +YW
Sbjct: 812 PLSGALASITETIQVHRRYW 831



 Score =  242 bits (617), Expect = 1e-63
 Identities = 147/384 (38%), Positives = 209/384 (54%), Gaps = 32/384 (8%)

Query: 522 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 581
           TGL+ D  + +  C   D+   PE   R+ +I  +L + GL  +C   + R A  EEL  
Sbjct: 86  TGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELML 143

Query: 582 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDT-DTIWNELHSSNAA 640
           VHS  ++ L  T       ++ G+L  L                DT D+++   +S + A
Sbjct: 144 VHSLEYIDLMETTQY----MNEGELRVL---------------ADTYDSVYLHPNSYSCA 184

Query: 641 RWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKA 700
             A+GSV  L   V   E++NG A++RPPGHHA HS   G+C FN VA+A R  QQ+ + 
Sbjct: 185 CLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRI 244

Query: 701 SKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVD--EVGAGSGEGFN 758
            ++LIVDWDVHHG GTQ TF QDPSVLY S+HR++ G F+P   A +    G G G+G+ 
Sbjct: 245 RRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYT 304

Query: 759 VNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS 818
           +NV W       M D +Y+AAF  V++P+A EF P LVLV+AGFDA +G P   G    +
Sbjct: 305 INVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPK--GEMAAT 359

Query: 819 AKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKP 878
              F  +T  LM LAGG ++L+LEGG++L A+ +   A +  LLG+    L   G    P
Sbjct: 360 PAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPG---AP 416

Query: 879 NLNAIRSLEAVIRVHSKYWGCMQR 902
             +A  S+   +     +W  + R
Sbjct: 417 CRSAQASVSCALEALEPFWEVLVR 440


>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
          Length = 669

 Score =  232 bits (592), Expect = 1e-60
 Identities = 145/383 (37%), Positives = 202/383 (52%), Gaps = 28/383 (7%)

Query: 522 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 581
           T L+Y   M   +    D     E   R+ +   RL++RGL  +C  L  R+AS EEL  
Sbjct: 3   TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62

Query: 582 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAAR 641
           VHS  +V L     +    L   +L  L  Q               D I+    + + AR
Sbjct: 63  VHSPEYVSLVRETQV----LGKEELQALSGQ--------------FDAIYFHPSTFHCAR 104

Query: 642 WAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKAS 701
            AAG+   L   V +  ++NG A+VRPPGHH   + A GFC FN+VAIA    +Q+    
Sbjct: 105 LAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLH 164

Query: 702 KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNV 759
           +IL+VDWDVHHG G Q  F  DPSVLY S HR++ G F+P       D VG G G GF V
Sbjct: 165 RILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTV 224

Query: 760 NVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA 819
           N+ W       MG+ +Y+AAF  +++P+A EF P+LVLVSAGFD+A G P   G    + 
Sbjct: 225 NLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE--GQMQATP 279

Query: 820 KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPN 879
           +CF ++TQ L  LAGG V   LEGG+ L ++ ++    V  LLG+   PLS       P 
Sbjct: 280 ECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLS---GPMAPC 336

Query: 880 LNAIRSLEAVIRVHSKYWGCMQR 902
            +A+ S+++     + +W  +Q+
Sbjct: 337 QSALESIQSARAAQAPHWKSLQQ 359



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 11/67 (16%)

Query: 776 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 835
           +L+    +V+P+A  F PDLVLV+ G     GH   L G H +      +   L  LAGG
Sbjct: 555 FLSCILGLVLPLAYGFQPDLVLVALG----PGH--GLQGPHAA-----LLAAMLRGLAGG 603

Query: 836 AVVLALE 842
            V+  LE
Sbjct: 604 RVLALLE 610


>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
          Length = 649

 Score =  197 bits (502), Expect = 3e-50
 Identities = 131/383 (34%), Positives = 186/383 (48%), Gaps = 48/383 (12%)

Query: 522 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 581
           T L+Y   M   +    D     E   R+ +   RL++RGL  +C  L  R+AS EEL  
Sbjct: 3   TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62

Query: 582 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAAR 641
           VHS  +V L     +    L   +L  L  Q               D I+    + + AR
Sbjct: 63  VHSPEYVSLVRETQV----LGKEELQALSGQ--------------FDAIYFHPSTFHCAR 104

Query: 642 WAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKAS 701
            AAG+   L   V +  ++NG A+VRPPGHH   + A GFC FN+VAIA    +Q+    
Sbjct: 105 LAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLH 164

Query: 702 KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNV 759
           +IL+VDWDVHHG G Q  F  DPSVLY S HR++ G F+P       D VG G G GF V
Sbjct: 165 RILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTV 224

Query: 760 NVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA 819
           N+ W       MG+ +Y+AAF  +++P+A E                      G    + 
Sbjct: 225 NLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQATP 259

Query: 820 KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPN 879
           +CF ++TQ L  LAGG V   LEGG+ L ++ ++    V  LLG+   PLS       P 
Sbjct: 260 ECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLS---GPMAPC 316

Query: 880 LNAIRSLEAVIRVHSKYWGCMQR 902
            +A+ S+++     + +W  +Q+
Sbjct: 317 QSALESIQSARAAQAPHWKSLQQ 339



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 11/67 (16%)

Query: 776 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 835
           +L+    +V+P+A  F PDLVLV+ G     GH   L G H +      +   L  LAGG
Sbjct: 535 FLSCILGLVLPLAYGFQPDLVLVALG----PGH--GLQGPHAA-----LLAAMLRGLAGG 583

Query: 836 AVVLALE 842
            V+  LE
Sbjct: 584 RVLALLE 590


>gi|13128860 histone deacetylase 1 [Homo sapiens]
          Length = 482

 Score =  108 bits (270), Expect = 2e-23
 Identities = 85/318 (26%), Positives = 138/318 (43%), Gaps = 61/318 (19%)

Query: 543 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 602
           HP    RI+   + L   GL  + E  R  KA+ EE+   HS+ ++       L  ++ D
Sbjct: 28  HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKF-----LRSIRPD 82

Query: 603 NGKLAGLLAQRM--------------FVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVT 648
           N        QR               F  L  GG  V +    N+  +  A  WA G   
Sbjct: 83  NMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVASAVKLNKQQTDIAVNWAGGL-- 139

Query: 649 DLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDW 708
                                 HHA  S A GFC+ N + +A  +L +  +  ++L +D 
Sbjct: 140 ----------------------HHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDI 175

Query: 709 DVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLD 768
           D+HHG+G ++ FY    V+ +S H++  G +FPG+G + ++GAG G+ + VN     G+D
Sbjct: 176 DIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGID 233

Query: 769 PPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS----AKCFGY 824
               D  Y A F+ V+  +   F P  V++  G D+  G    LG ++++    AKC  +
Sbjct: 234 ----DESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGD--RLGCFNLTIKGHAKCVEF 287

Query: 825 MTQ---QLMNLAGGAVVL 839
           +      ++ L GG   +
Sbjct: 288 VKSFNLPMLMLGGGGYTI 305


>gi|116284376 histone deacetylase 2 [Homo sapiens]
          Length = 582

 Score =  104 bits (260), Expect = 3e-22
 Identities = 77/292 (26%), Positives = 125/292 (42%), Gaps = 54/292 (18%)

Query: 543 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 602
           HP    RI+   + L   GL  + E  R  KA+ EE+   HS+ ++       L  ++ D
Sbjct: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKF-----LRSIRPD 177

Query: 603 NGKLAGLLAQRM--------------FVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVT 648
           N        QR               F  L  GG  V      N   +  A  WA G   
Sbjct: 178 NMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL-- 234

Query: 649 DLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDW 708
                                 HHA  S A GFC+ N + +A  +L +  +  ++L +D 
Sbjct: 235 ----------------------HHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDI 270

Query: 709 DVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLD 768
           D+HHG+G ++ FY    V+ +S H++  G +FPG+G + ++GAG G+ + VN     G+D
Sbjct: 271 DIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID 328

Query: 769 PPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAK 820
               D  Y   F+ ++  +   + P  V++  G D+  G    LG ++++ K
Sbjct: 329 ----DESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD--RLGCFNLTVK 374


>gi|8923769 histone deacetylase 8 [Homo sapiens]
          Length = 377

 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 65/190 (34%), Positives = 93/190 (48%), Gaps = 26/190 (13%)

Query: 671 HHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYIS 730
           HHA    A GFC+ N   +   +L++  K  +IL VD D+HHG+G +  F     V+ +S
Sbjct: 142 HHAKKDEASGFCYLNDAVLGILRLRR--KFERILYVDLDLHHGDGVEDAFSFTSKVMTVS 199

Query: 731 LHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIARE 790
           LH+   G FFPG+G V +VG G G  ++VNV    G+     D +Y      V+  + + 
Sbjct: 200 LHKFSPG-FFPGTGDVSDVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQA 254

Query: 791 FSPDLVLVSAGFDAAEGHP------APLGGYHVSAKCFGYMTQ-QLMNLAGGAVVLALEG 843
           F+P  V++  G D   G P       P+G      KC  Y+ Q QL  L  G       G
Sbjct: 255 FNPKAVVLQLGADTIAGDPMCSFNMTPVG----IGKCLKYILQWQLATLILGG------G 304

Query: 844 GHDL--TAIC 851
           G++L  TA C
Sbjct: 305 GYNLANTARC 314


>gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]
          Length = 590

 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 130/468 (27%), Positives = 187/468 (39%), Gaps = 104/468 (22%)

Query: 59  LALQRPQRLHHHL--FLAGLQQQRSVEP-MRLSMDTPMPELQVGPQEQELRQLLHKDKSK 115
           L  Q   +L  H+   LA  QQQ  +E   +L       E++   +EQ+L  L  KD+ +
Sbjct: 75  LTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGR 134

Query: 116 RSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP 175
             AVAS+ VKQKL E +L K   +  +    N           L    A  + L    PP
Sbjct: 135 ERAVASTEVKQKLQEFLLSK---SATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPP 191

Query: 176 VP--------SLP--SDPPEHFPLRKTVSEPNLKLRYKPK-KSLERRKNPLLRKE--SAP 222
           +         +LP   D  + FPLRKT SEPNLK+R + K K  ERR +PLLR++  +  
Sbjct: 192 LSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVV 251

Query: 223 PSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHG-----------PNPILGSEADSDR- 270
            S ++R  E     S  SSS+P SG SSPN+   G           P P         R 
Sbjct: 252 TSFKKRMFEV--TESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRI 309

Query: 271 ------------RTHPTLGPRGPILGSPHTPLFLPHG-------------------LEPE 299
                        T P+L      LG P  P  L                      L  +
Sbjct: 310 LIHEDSMNLLSLYTSPSL--PNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQ 367

Query: 300 AGGTLP-SRLQPILLLD---PSGSHAPLL------------TVPGLGPLPFHFAQSLMTT 343
            GG++P S   P + L+   P+ SH  LL             +   G +P H    L T 
Sbjct: 368 YGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATK 427

Query: 344 ERLSGS-------GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKP 396
           ER+S           H PL+RT+S PLP S  A         +L   + H Q +++  + 
Sbjct: 428 ERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLA---------QLVIQQQHQQFLEKQKQY 478

Query: 397 SEKPRLRQI--PSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPA 442
            ++  + ++   S E L+     PG  +++  E  +      E R P+
Sbjct: 479 QQQIHMNKLLSKSIEQLKQ----PGSHLEEAEEELQGDQAMQEDRAPS 522



 Score = 33.5 bits (75), Expect = 0.97
 Identities = 51/210 (24%), Positives = 82/210 (39%), Gaps = 38/210 (18%)

Query: 76  LQQQRSVEPMRLSMDTPMPELQVG--PQEQELRQLLHKDKSKRSAVASSVVKQKLAEVIL 133
           L++++  E   L    P+P    G  P       +  + K   S+       Q L + +L
Sbjct: 347 LKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSS------HQALLQHLL 400

Query: 134 KKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTV 193
            K+Q   ++ +     G+P     PL    AT+  +S  +     LP     H PL +T 
Sbjct: 401 LKEQMRQQKLLVAG--GVPLHPQSPL----ATKERISPGIRGTHKLP----RHRPLNRTQ 450

Query: 194 SEP-------NLKLRYKPKKSLERRK--------NPLLRKE----SAPPS-LRRRPAETL 233
           S P        L ++ + ++ LE++K        N LL K       P S L     E  
Sbjct: 451 SAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQ 510

Query: 234 GDSSPSSSSTPASGCSSPNDSEHGPNPILG 263
           GD +      P+SG S+ +DS    +  LG
Sbjct: 511 GDQAMQEDRAPSSGNSTRSDSSACVDDTLG 540


>gi|13128862 histone deacetylase 3 [Homo sapiens]
          Length = 428

 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 47/135 (34%), Positives = 74/135 (54%), Gaps = 9/135 (6%)

Query: 671 HHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYIS 730
           HHA    A GFC+ N + I   +L +     ++L +D D+HHG+G Q+ FY    V+ +S
Sbjct: 134 HHAKKFEASGFCYVNDIVIGILELLKYHP--RVLYIDIDIHHGDGVQEAFYLTDRVMTVS 191

Query: 731 LHRHDDGN-FFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAR 789
            H++  GN FFPG+G + EVGA SG  + +NV    G+D    D  Y   F+ V+  +  
Sbjct: 192 FHKY--GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGID----DQSYKHLFQPVINQVVD 245

Query: 790 EFSPDLVLVSAGFDA 804
            + P  +++  G D+
Sbjct: 246 FYQPTCIVLQCGADS 260


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 132/565 (23%), Positives = 183/565 (32%), Gaps = 66/565 (11%)

Query: 4   PGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPP-------------- 49
           P A    ++P +    P+    P P A  P   P  M     Q PP              
Sbjct: 336 PLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSL 395

Query: 50  ----VEPPPEP---------TLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTP--MP 94
               ++ PP P         T L     Q  H  L ++  Q Q S+        TP   P
Sbjct: 396 TSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSP 455

Query: 95  ELQVG---PQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGI 151
            LQ     P    L+  L    S  S+  +    Q L+ +     QA L   + P     
Sbjct: 456 PLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMP----- 510

Query: 152 PYRTLEPLETEGATRSMLSSFLPPVPSLPS-DPPEHFPLRKTVSEPNLKLRYKPKK-SLE 209
           P  T   L          S   PP+ +LPS  PP        ++ P+L+    P    L+
Sbjct: 511 PLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQ 570

Query: 210 RRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEADSD 269
              +PL    + PP      A     + P+ +S P  G  SP  S     P    +A   
Sbjct: 571 APPSPL---TTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPP---PQAPPX 624

Query: 270 RRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSR-LQPILLLDPSGSHAPLLTVPG 328
               P   P  P    P +PL  P    P+A   L    LQ      PS       + P 
Sbjct: 625 LALPPLQAPPSPPASPPLSPLATP---SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 681

Query: 329 LGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPP--PPGPMQPRLEQLKTH 386
             P+             L+   L  P S   S P+ PSAT PP  PP    P L+   + 
Sbjct: 682 SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSP 741

Query: 387 VQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQ 446
                 S   +  PR+  + +A  L+     P  +    L        +P  + P  L  
Sbjct: 742 PASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPL-------AKPPPQAPPALAT 794

Query: 447 HP-QVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHR-------PLSRAQSSPAAPASLSA 498
            P Q L        G+ P   +    + PLA    +       PL +   SP A  +L A
Sbjct: 795 PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 854

Query: 499 PEPASQARVLSSSETPARTLPFTTG 523
           P         +S   P  TL    G
Sbjct: 855 PRRPPTPGPDTSVSGPRLTLALAPG 879



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 132/519 (25%), Positives = 187/519 (36%), Gaps = 69/519 (13%)

Query: 27  RPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMR 86
           RP +  P   P    L +   PP++    P +  L  P  +H    L+ L          
Sbjct: 446 RPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASH------- 498

Query: 87  LSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQ--KLAEVILKKQQAALERTV 144
            S   P+  L + P E +        ++  +++ +  ++    LA   L+   A L  T 
Sbjct: 499 -SPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPL-TTP 556

Query: 145 HPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKP 204
           H  +P  P     PL+   A  S L++  P  PS  + PP   P    ++ P L+    P
Sbjct: 557 HLETPPCPAPC--PLQ---APPSPLTTPPPETPSSIATPPPQAP--PALASPPLQGLPSP 609

Query: 205 KKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPI--- 261
             S      P      APP L   P +     SP  +S P S  ++P  S   PN +   
Sbjct: 610 PLSPLATPPP-----QAPPXLALPPLQ--APPSP-PASPPLSPLATP--SPQAPNALAVH 659

Query: 262 LGSEADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHA 321
           L     S   + P   P  P    P +P   P    P      PS   P L + PS   +
Sbjct: 660 LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP------PSLAAPPLQVPPSPPAS 713

Query: 322 PLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPP--PPGPMQPR 379
           P ++ P   P P            L+   L  P S   S P+ PSAT PP  PP    P 
Sbjct: 714 PPMS-PSATPPP-------QAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPP 765

Query: 380 LEQLKTHVQVIKRS--AKPSEK--PRLRQIPSAEDLETDGGGPGQV---VDDGLEHRELG 432
           L+   +    +  S  AKP  +  P L   P           PGQ        L    L 
Sbjct: 766 LQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLA 825

Query: 433 HGQPEARG--PAPLQQHPQVLLWEQQRLAGRLP------RGSTGDTVLLPLAQGGHRPLS 484
              P+A     APL Q P          A R P         +G  + L LA G   P S
Sbjct: 826 TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 885

Query: 485 RAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTG 523
           R+ SS     +LS P+ A  +   S++ TP     + +G
Sbjct: 886 RSPSS-----TLSGPDLAGHSS--SATSTPEELRGYDSG 917



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 95/421 (22%), Positives = 134/421 (31%), Gaps = 97/421 (23%)

Query: 113 KSKRSAVASSVVKQKLAEVILKKQ-QAALERTVHPNSPGIPYRTLEPLETEGATRSMLSS 171
           K  R +   +V + K  E   +    A   R     +PG P   +        T   L  
Sbjct: 132 KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR 191

Query: 172 FLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAE 231
              P PS    PP   P RK+VS  +     +P                  P+ RRRP+ 
Sbjct: 192 ---PAPSARPRPPTEGP-RKSVSSASEHSTTEPS-----------------PAARRRPSA 230

Query: 232 TLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPLF 291
             G   P+S S  +S     + +  GP+                        G+P  P  
Sbjct: 231 GGGLQRPASRSLSSSATPLSSPARSGPS----------------------ARGTPRAP-- 266

Query: 292 LPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGL 351
             H  +P+  G     L+P  +  P    A     P LGPL    + S + T   SG   
Sbjct: 267 -AHPSQPKPKGL--QALRPPQVTPPRKDAA-----PALGPL----SSSPLATPSPSG--- 311

Query: 352 HWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDL 411
                 T++ P+PP   A  P     P    L T + +   S  PS  P L+ +PS    
Sbjct: 312 ------TKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPS--PSAPPSLQTLPSPPAT 363

Query: 412 ETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQ------QRLAGRLPRG 465
                 P                 P  + P  LQ  P + +         Q     L   
Sbjct: 364 PPSQAPPSMTT-------------PPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALS 410

Query: 466 STGDTVLL--PLAQGGH-------RPLSRAQSSPAAPASLSAPEPASQARVLSSSETPAR 516
           S   T  L  P  Q  H       R    + +SP+ PAS     P  QA +   +  P +
Sbjct: 411 SLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQ 470

Query: 517 T 517
           T
Sbjct: 471 T 471



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 109/450 (24%), Positives = 149/450 (33%), Gaps = 49/450 (10%)

Query: 20  PTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPP---EPTLLALQRPQRLHHHLFLAGL 76
           P  A CP     +P   P P        PP + PP    P L  L  P        L+ L
Sbjct: 562 PCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPP-------LSPL 614

Query: 77  QQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQ 136
                  P  L++  P+      P    L  L        +A+A  +++   +       
Sbjct: 615 ATPPPQAPPXLAL-PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV 673

Query: 137 QA--------ALERTVHPNSPGIPYRTLEPLE---TEGATRSMLSSFLPPVPSLP--SDP 183
           QA         +  +  P S   P     PL+   +  A+  M  S  PP  + P  + P
Sbjct: 674 QAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAP 733

Query: 184 PEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPP-SLRRRP-AETLGDSSPSSS 241
           P   P     S P       P +       P L+   +PP SL   P A+    + P+ +
Sbjct: 734 PLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALA 793

Query: 242 STPASGCSSPNDSEHGPNPILGSEA--DSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPE 299
           + P     SP  S  G  P   S +   S   T P   P  P+L +P     L     P 
Sbjct: 794 TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP--PVLAAP----LLQVPPSPP 847

Query: 300 AGGTLPSRLQPILLLDPSGSHAPLLTV---PGLGPLPFHFAQSLMTTERLSG---SGLHW 353
           A  TL +  +P      +    P LT+   PG  P P     S ++   L+G   S    
Sbjct: 848 ASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATST 907

Query: 354 PLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLET 413
           P      +  P    A  PP    P  E    H     R   P+     R  P A     
Sbjct: 908 PEELRGYDSGPEGGAAASPP----PDAELAACHPAAWSRG--PAPPLAFRGAPGAPLPWP 961

Query: 414 DGGGPGQVVDDGLEHRELGHGQPEARGPAP 443
              GPG    DGL       G PE+  PAP
Sbjct: 962 PATGPGSA--DGLCTIYETEG-PESATPAP 988



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 88/373 (23%), Positives = 118/373 (31%), Gaps = 51/373 (13%)

Query: 174 PPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETL 233
           P  P  P  PP   P    V      +  KP              ESAP   R  P  + 
Sbjct: 27  PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAP---RAGPTRSA 83

Query: 234 GDSSPSSSSTPAS---GCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPL 290
           G SS + +S P +   G  +P      P P+      S       LG +G  + +  T  
Sbjct: 84  GTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEET-- 141

Query: 291 FLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSG 350
            +  G   EA     S L      D S            GP P   + ++    R +G+ 
Sbjct: 142 -VARGKATEA--PKRSALSAGARRDTS------------GPTPGTPSPAMARRSRAAGTE 186

Query: 351 LHWPLSRTRSEPLPP--------------SATAPPPPGPMQPRL--EQLKTHVQVIKRSA 394
           +  P     + P PP              S T P P    +P       +   + +  SA
Sbjct: 187 VGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSA 246

Query: 395 KPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPA----PLQQHPQV 450
            P   P  R  PSA         P Q    GL+        P  +  A    PL   P  
Sbjct: 247 TPLSSP-ARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA 305

Query: 451 LLWEQQRLAGRLPRGSTGDTVL---LPLAQGGHRPLSRAQSSPAAPASL-SAPEPASQAR 506
                   A  +P      T L   LP +     PL  A  SP+AP SL + P P +   
Sbjct: 306 TPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATP- 364

Query: 507 VLSSSETPARTLP 519
              S   P+ T P
Sbjct: 365 --PSQAPPSMTTP 375


>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
          Length = 347

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 69/278 (24%), Positives = 113/278 (40%), Gaps = 40/278 (14%)

Query: 543 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 602
           HP  AG+   + + L+E  L S    +  R+AS E+L  VH+ R+        L+ LK  
Sbjct: 35  HPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LNELKWS 86

Query: 603 NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG 662
              +A +      + LP   V      +   L +       AG +           ++ G
Sbjct: 87  FA-VATITEIPPVIFLPNFLV---QRKVLRPLRTQTGGTIMAGKLA----------VERG 132

Query: 663 FAVVRPPG-HHADHSTAMGFCFFNSVAIACRQLQQQSKA-SKILIVDWDVHHGNGTQQTF 720
           +A+    G HH       GFC +  + +A + L ++ +  S+  I+D D H GNG ++ F
Sbjct: 133 WAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDF 192

Query: 721 YQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAF 780
             D  V  + ++     + +PG     +  A       V + W         D EYL   
Sbjct: 193 MDDKRVYIMDVYNR---HIYPG-----DRFAKQAIRRKVELEWG------TEDDEYLDKV 238

Query: 781 RIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS 818
              +    +E  PD+V+ +AG D  EG    LGG  +S
Sbjct: 239 ERNIKKSLQEHLPDVVVYNAGTDILEGD--RLGGLSIS 274


>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
          Length = 296

 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 67/279 (24%), Positives = 104/279 (37%), Gaps = 65/279 (23%)

Query: 543 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 602
           HP  AG+   + + L+E  L S    +  R+AS E+L  VH+ R++       L  L+  
Sbjct: 7   HPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKRKVLRPLRTQ 66

Query: 603 NGK--LAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELK 660
            G   +AG LA      +  GG                                      
Sbjct: 67  TGGTIMAGKLAVERGWAINVGG-------------------------------------- 88

Query: 661 NGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKA-SKILIVDWDVHHGNGTQQT 719
            GF       HH       GFC +  + +A + L ++ +  S+  I+D D H GNG ++ 
Sbjct: 89  -GF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERD 140

Query: 720 FYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAA 779
           F  D  V  + ++     + +PG     +  A       V + W         D EYL  
Sbjct: 141 FMDDKRVYIMDVYNR---HIYPG-----DRFAKQAIRRKVELEWG------TEDDEYLDK 186

Query: 780 FRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVS 818
               +    +E  PD+V+ +AG D  EG    LGG  +S
Sbjct: 187 VERNIKKSLQEHLPDVVVYNAGTDILEGD--RLGGLSIS 223


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 134/541 (24%), Positives = 186/541 (34%), Gaps = 83/541 (15%)

Query: 26   PRPCADTPGPQPQPMDLRV-GQRPPVEPPPE-PTLLALQRPQRLHHHLFLAGLQQQRSVE 83
            PRP      P+P+   L    + P + P PE P L A+  P+  H      G       E
Sbjct: 745  PRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAV--PEEPHLSPQAEGPHLSPQPE 802

Query: 84   PMRLSMDTPMPELQVGPQEQELR---QLLHKDKSKRSAVASSVVKQKLAEVILKKQQAAL 140
             + LS  T  P L   P+E  L    +  H          S   ++      L+K   + 
Sbjct: 803  ELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSP 862

Query: 141  ERTVHPNSPG-IPYRTLEPLETEGATRSMLSSFLPPVPSLPSDP-----PEHFPLRKTVS 194
                 P  PG  P     PL       S+      P  S P +P     PE  PL  +  
Sbjct: 863  RPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPS-G 921

Query: 195  EPNLKLRYKPKKSLERRKNPLLRKESAPPSLR-----RRPAETLGDSSPSS--------- 240
            EP+L  +  P   L    +P++   +APP+L        P    GDS P S         
Sbjct: 922  EPSLSPQLMPPDPLPPPLSPII-TAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILET 980

Query: 241  --SSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPL---FLPHG 295
              S  P + C+ P   E  P  IL     S       +GP  PIL  P  P     L H 
Sbjct: 981  PISPPPEANCTDP---EPVPPMILPPSPGS------PVGPASPILMEPLPPQCSPLLQHS 1031

Query: 296  LEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPL 355
            L P+   + PS+  P  L  P    +PL  +  +  +        M TE+         +
Sbjct: 1032 LVPQ--NSPPSQCSPPAL--PLSVPSPLSPIGKVVGVSDEAELHEMETEK---------V 1078

Query: 356  SRTRSEPLPPSATAP------------PPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLR 403
            S      L PSAT+P            P P P       L      +     P  +P   
Sbjct: 1079 SEPECPALEPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPG 1138

Query: 404  QIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLP 463
            Q P +   E  G     V+   L+  EL    P    P   Q   Q    E+Q    R P
Sbjct: 1139 QTPGSLASELKG---SPVL---LDPEELAPVTPMEVYPECKQTAGQGSPCEEQE-EPRAP 1191

Query: 464  RGSTGDTVLLPLAQGGHRPLSRAQSSPAAPAS---LSAPEP-----ASQARVLSSSETPA 515
               T  T++          LS+  +S + P S   L +P+P      S    +S+  +PA
Sbjct: 1192 VAPTPPTLIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPA 1251

Query: 516  R 516
            R
Sbjct: 1252 R 1252



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 119/518 (22%), Positives = 167/518 (32%), Gaps = 78/518 (15%)

Query: 37   PQPMDLRVGQRP---PVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPM 93
            P P   R+   P   P+ PPPE + ++   P      LF    +   S  P    +  P 
Sbjct: 565  PPPEASRLSPPPEESPMSPPPEESPMS---PPPEASRLFPPFEESPLSPPPEESPLSPPP 621

Query: 94   PELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPY 153
               ++ P  ++       ++S  S     V +     V+ +      E  + P     P 
Sbjct: 622  EASRLSPPPEDSPMSPPPEESPMSP-PPEVSRLSPLPVVSRLSPPPEESPLSPPPEESP- 679

Query: 154  RTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKN 213
             T  P E      S LS   PP  S  S PPE  P      +  + L  +    L   + 
Sbjct: 680  -TSPPPEA-----SRLSP--PPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEE 731

Query: 214  PLLRKESAPPSLRRRPAE------------TLGDSSPSSSSTPASGC-----SSPNDSEH 256
            P L   S  P L  RP E            +     P  S  P   C       P+ S  
Sbjct: 732  PQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQ 791

Query: 257  GPNPILGSEAD----SDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPIL 312
               P L  + +    S +   P L P       P  P   P   +PE     P   +P L
Sbjct: 792  AEGPHLSPQPEELHLSPQTEEPHLSP------VPEEPCLSP---QPEESHLSPQSEEPCL 842

Query: 313  LLDPSGSH-APLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPL--PPSATA 369
               P  SH +P L  P L P P    +            L  P       PL   P+ + 
Sbjct: 843  SPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSE 902

Query: 370  PPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQ----IPSAEDLETDGGGPGQVVDDG 425
            P  P P+ P  E+L      +  S +PS  P+L       P    + T    P       
Sbjct: 903  PGEP-PLSPLPEELP-----LSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGE 956

Query: 426  LEH--RELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPL 483
            LE+     G   PE+   AP+ + P              P  +  D   +P        L
Sbjct: 957  LEYPFGAKGDSDPESPLAAPILETP----------ISPPPEANCTDPEPVP-----PMIL 1001

Query: 484  SRAQSSPAAPAS--LSAPEPASQARVLSSSETPARTLP 519
              +  SP  PAS  L  P P   + +L  S  P  + P
Sbjct: 1002 PPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPP 1039



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 99/391 (25%), Positives = 122/391 (31%), Gaps = 59/391 (15%)

Query: 48  PPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQ 107
           PP E PP P   AL+ P                S  P    +  P  E  + P  +EL  
Sbjct: 522 PPEESPPSP---ALETP---------------LSPPPEASPLSPPFEESPLSPPPEELPT 563

Query: 108 LLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHP--NSPGIPYRTLEPLETEGAT 165
               + S+ S            E           R   P   SP  P     PL +    
Sbjct: 564 SPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPL-SPPPE 622

Query: 166 RSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPP-- 223
            S LS   PP  S  S PPE  P+    S P    R  P   + R   P      +PP  
Sbjct: 623 ASRLSP--PPEDSPMSPPPEESPM----SPPPEVSRLSPLPVVSRLSPPPEESPLSPPPE 676

Query: 224 ---------SLRRRPAETLGDSSPSSSSTPASGCSSPNDS------EHGPNPILGSEAD- 267
                    + R  P      +SP    +PAS    P DS      E  P   L  E   
Sbjct: 677 ESPTSPPPEASRLSPPPEDSPTSPPPEDSPAS--PPPEDSLMSLPLEESPLLPLPEEPQL 734

Query: 268 SDRRTHPTLGPRGP---ILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSH-APL 323
             R   P L PR     +   P  P   P   EP      P   +P L   P   H +P 
Sbjct: 735 CPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLS---PQPEEPCLCAVPEEPHLSPQ 791

Query: 324 LTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEP--LPPSATAP-PPPGPMQPRL 380
              P L P P     S  T E         P    + E   L P +  P   P P +  L
Sbjct: 792 AEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHL 851

Query: 381 EQLKTHVQVIKRSAKPSEKPRLRQIPSAEDL 411
                   +  R  KP E+P   Q P+ E+L
Sbjct: 852 SPELEKPPLSPRPEKPPEEP--GQCPAPEEL 880



 Score = 37.0 bits (84), Expect = 0.088
 Identities = 114/502 (22%), Positives = 181/502 (36%), Gaps = 102/502 (20%)

Query: 47   RPPVEPPPEPTLLALQRPQRLHHHLFLAG-----LQQQRSVEPMRLSMDTPMPELQVGPQ 101
            +P +   P  +L  LQ+ Q+L     L       LQQQ+ ++  +L       +LQ   Q
Sbjct: 3886 QPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQ 3945

Query: 102  ---EQELRQLLHKDKSKRSAVASSVVKQKL-----AEVILKKQQAALERTVHPNSPGIPY 153
               +Q+ +QL  + + ++        +Q++     +  +L  QQ   ++      PG+P 
Sbjct: 3946 QQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVA--LGPGMPA 4003

Query: 154  RTLEPLETEGA-------TRSMLSSFLPPVPSLPSDPP---EHFPLR-KTVSEPNLKLRY 202
            + L+   + GA       T    ++  P V S  ++ P   +  PL   T  E       
Sbjct: 4004 KPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPG 4063

Query: 203  KPKKSLERRKNPLL---RKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPN 259
            + K SL      LL   + +  P SL+ +P   L    P       S   +     HG  
Sbjct: 4064 EVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRL----PGQQQQQVSLLHTAGGGSHGQ- 4118

Query: 260  PILGSEADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGS 319
              LGS + S+  + P L      L  P   L           G  P  +   LL    G 
Sbjct: 4119 --LGSGSSSEASSVPHL------LAQPSVSL-----------GDQPGSMTQNLL----GP 4155

Query: 320  HAPLLTVP---GLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPM 376
              P+L  P     GP P      L + + L G G+   + + R++ L       P    +
Sbjct: 4156 QQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQ-LQGVLAKNPQLRHL 4214

Query: 377  QPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETD--------------GGGPGQVV 422
             P+ +Q    +Q +    +  +   +RQ P  ++  T               GG PG   
Sbjct: 4215 SPQQQQ---QLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQT 4271

Query: 423  DDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRP 482
                  +ELG G P  +GP  L   P  L              STG  VL P+      P
Sbjct: 4272 G---PLQELGAG-PRPQGPPRLPAPPGAL--------------STG-PVLGPVHP---TP 4309

Query: 483  LSRAQSSPAAPASLSAPEPASQ 504
               +   P  P+ L  P P+SQ
Sbjct: 4310 PPSSPQEPKRPSQL--PSPSSQ 4329



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 109/494 (22%), Positives = 161/494 (32%), Gaps = 93/494 (18%)

Query: 80   RSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQ-KLAEVILKKQQA 138
            R  + M+L    P  +     Q+ +  +  H+    +    S + KQ K+ ++  K  + 
Sbjct: 2041 RCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDIARKTDRP 2100

Query: 139  ALERTVHP------NSPGIPYRTL---EPLETEGATRSMLSSFLPPVPSLPSDP------ 183
            AL   + P      + P     T+    P    G + S      PP  S+P         
Sbjct: 2101 ALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELF 2160

Query: 184  ---PEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSP-- 238
               P   P +    +P       P   LE R        +APP+    P+ T   + P  
Sbjct: 2161 LKLPPQVPAQVPSQDP---FGLAPAYPLEPRF------PTAPPTYPPYPSPTGAPAQPPM 2211

Query: 239  -SSSSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPLFLPHGLE 297
              +SS P +G   P +    P    G+         P L PR P L +   P        
Sbjct: 2212 LGASSRPGAG--QPGEFHTTPP---GTPRHQPSTPDPFLKPRCPSLDNLAVPE------S 2260

Query: 298  PEAGGTLPSRLQPILLLDPSGSHAPLLTV---------PGLGPLPFHFAQSLMTTERLSG 348
            P  GG   S  +P+L   P G     L V         P  GP    F  S  +   L G
Sbjct: 2261 PGVGGGKAS--EPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGG 2318

Query: 349  SGLHWP--------------------LSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQ 388
              L  P                    L     EP P  A AP PP           +H  
Sbjct: 2319 LELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPP-----------SHPD 2367

Query: 389  VIKRSA--KPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQ 446
            + +  +   P  +P L   P     E+    P + +      R     Q ++   +PL  
Sbjct: 2368 IFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLT- 2426

Query: 447  HPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPA-APASLSAPEPASQA 505
             P+ L  E    +   PR  + D    P ++   RP SR   +P   P     PE A +A
Sbjct: 2427 -PRPLSAEAFCPSPVTPRFQSPD----PYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKA 2481

Query: 506  RVLSSSETPARTLP 519
              L+ +   A   P
Sbjct: 2482 GSLAHTSLGAGGFP 2495



 Score = 30.8 bits (68), Expect = 6.3
 Identities = 94/436 (21%), Positives = 142/436 (32%), Gaps = 91/436 (20%)

Query: 13   PGAHYCSPTGAGC-PRPCADTPG----------------PQPQPMDLRVGQRPPVEPPPE 55
            P  H   P   G  P   A  PG                PQPQP    +  +PP+  P +
Sbjct: 4041 PSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQ 4100

Query: 56   PTLLALQRPQRLH------HHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLL 109
                  Q+   LH      H    +G   + S  P  L+     P + +G Q   + Q L
Sbjct: 4101 QQ----QQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLA----QPSVSLGDQPGSMTQNL 4152

Query: 110  HKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNS---PGIPYRTLEP-------- 158
                                   L  QQ  LER +  N+   P  P   L+         
Sbjct: 4153 -----------------------LGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVG 4189

Query: 159  -LETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLR 217
             + T G  R+ L   L   P L      H   ++      L ++ + ++S   R+ P  +
Sbjct: 4190 IMPTVGQLRAQLQGVLAKNPQL-----RHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQ 4244

Query: 218  KESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLG 277
            +    P  +  P + L    P     P        +   GP P    +        P   
Sbjct: 4245 E----PGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRP----QGPPRLPAPPGAL 4296

Query: 278  PRGPILGSPHTPLFLPHGLEPEAGGTLP---SRLQPILLLDPSGSHAPLLTVPGLGPLPF 334
              GP+LG  H         EP+    LP   S+L     L P+    P    P L P P 
Sbjct: 4297 STGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPG 4356

Query: 335  HFA-QSLMTTERLSGSGL-HWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKR 392
              +  +    + L   GL  W      +E   P  ++  P       L+Q+  + QV+  
Sbjct: 4357 RVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVP-----GHLDQV--NGQVVPE 4409

Query: 393  SAKPSEKPRLRQIPSA 408
            +++ S K   R+ P A
Sbjct: 4410 ASQLSIKQEPREEPCA 4425


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 112/554 (20%), Positives = 176/554 (31%), Gaps = 82/554 (14%)

Query: 3   SPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQ 62
           +P A+ T   P            P+  A T   +P P  ++     P EP P  T  A  
Sbjct: 198 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 257

Query: 63  RPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASS 122
            P+                 EP   +   P P     P          K+ +  +  ++ 
Sbjct: 258 TPK-----------------EPAPTTTKEPAPTTPKEPAPTTT-----KEPAPTTTKSAP 295

Query: 123 VVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSD 182
              ++ A    KK      +   P +P  P  T  P E    T+        P P+ P +
Sbjct: 296 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT-PKEPAPTTKE-------PAPTTPKE 347

Query: 183 PPEHFPLRK---TVSEPNLKLRYKPKKSLERRKNPLLRKESAP------PSLRRRPAETL 233
           P    P +    T  EP      +P  +  +  +P   KE AP      P+  + PA T 
Sbjct: 348 PAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 407

Query: 234 GDSSPSSSSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPL--- 290
             S+P++   P    S     E  P         + ++  PT  P+ P   +P  P    
Sbjct: 408 TKSAPTTPKEP----SPTTTKEPAPTTPKEPAPTTPKKPAPTT-PKEPAPTTPKEPAPTT 462

Query: 291 ------FLPHGLEP----EAGGTLPSRLQPIL--LLDPSGSHAPLLTVP-------GLGP 331
                   P    P    E   T P +L P     L P+    P  T P          P
Sbjct: 463 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP 522

Query: 332 LPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIK 391
            P    +   TT + +    + P     + P  P+ T P  P P  P+ E   T  +   
Sbjct: 523 TPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKEPAPTTPKEPAPTTPK-ETAPTTPKGTA 579

Query: 392 RSAKPSEKPRLRQIPSAEDL--ETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQ 449
            +      P   + P+ ++L   T         D        G      + PAP      
Sbjct: 580 PTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT----- 634

Query: 450 VLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSR--AQSSPAAPASLSAPEPASQARV 507
                 +  A   P+G+   T+  P      +P  +  A ++   P S ++ +PA     
Sbjct: 635 ----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPK 690

Query: 508 LSSSETPARTLPFT 521
            ++  TP    P T
Sbjct: 691 ETAPTTPKEPAPTT 704



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 87/414 (21%), Positives = 130/414 (31%), Gaps = 44/414 (10%)

Query: 19  SPTGAGCPRPCADTPGP----QPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLA 74
           SPT    P P      P    +P P   +     P EP P  T        +        
Sbjct: 381 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK-------- 432

Query: 75  GLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILK 134
              +     P + +  TP       P+E           +     A +  K+  A    K
Sbjct: 433 ---EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKET-APTTPK 488

Query: 135 KQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLR---K 191
           K        + P +P  P  T  P E    T         P P+ P +P    P      
Sbjct: 489 KLTPTTPEKLAPTTPEKPAPTT-PEELAPTTPE------EPTPTTPEEPAPTTPKAAAPN 541

Query: 192 TVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSP 251
           T  EP      +P  +  +   P   KE+AP + +     TL + +P++   PA    +P
Sbjct: 542 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 601

Query: 252 NDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPL-FLPHGLEP----EAGGTLPS 306
             ++   +      A +  +      P+ P   +P  P    P G  P    E   T P 
Sbjct: 602 TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK 661

Query: 307 RLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPS 366
           +  P   L P+ +  P  T     P P    ++  TT          P     + P  P+
Sbjct: 662 KPAP-KELAPTTTKGPTSTTSD-KPAPTTPKETAPTT----------PKEPAPTTPKKPA 709

Query: 367 ATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEK-PRLRQIPSAEDLETDGGGPG 419
            T P  P P    +    T  +       P E  P L   P+ + LE     PG
Sbjct: 710 PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 763


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 112/554 (20%), Positives = 176/554 (31%), Gaps = 82/554 (14%)

Query: 3   SPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQ 62
           +P A+ T   P            P+  A T   +P P  ++     P EP P  T  A  
Sbjct: 239 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 298

Query: 63  RPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASS 122
            P+                 EP   +   P P     P          K+ +  +  ++ 
Sbjct: 299 TPK-----------------EPAPTTTKEPAPTTPKEPAPTTT-----KEPAPTTTKSAP 336

Query: 123 VVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSD 182
              ++ A    KK      +   P +P  P  T  P E    T+        P P+ P +
Sbjct: 337 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT-PKEPAPTTKE-------PAPTTPKE 388

Query: 183 PPEHFPLRK---TVSEPNLKLRYKPKKSLERRKNPLLRKESAP------PSLRRRPAETL 233
           P    P +    T  EP      +P  +  +  +P   KE AP      P+  + PA T 
Sbjct: 389 PAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 448

Query: 234 GDSSPSSSSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPL--- 290
             S+P++   P    S     E  P         + ++  PT  P+ P   +P  P    
Sbjct: 449 TKSAPTTPKEP----SPTTTKEPAPTTPKEPAPTTPKKPAPTT-PKEPAPTTPKEPAPTT 503

Query: 291 ------FLPHGLEP----EAGGTLPSRLQPIL--LLDPSGSHAPLLTVP-------GLGP 331
                   P    P    E   T P +L P     L P+    P  T P          P
Sbjct: 504 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP 563

Query: 332 LPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIK 391
            P    +   TT + +    + P     + P  P+ T P  P P  P+ E   T  +   
Sbjct: 564 TPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKEPAPTTPKEPAPTTPK-ETAPTTPKGTA 620

Query: 392 RSAKPSEKPRLRQIPSAEDL--ETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQ 449
            +      P   + P+ ++L   T         D        G      + PAP      
Sbjct: 621 PTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT----- 675

Query: 450 VLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSR--AQSSPAAPASLSAPEPASQARV 507
                 +  A   P+G+   T+  P      +P  +  A ++   P S ++ +PA     
Sbjct: 676 ----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPK 731

Query: 508 LSSSETPARTLPFT 521
            ++  TP    P T
Sbjct: 732 ETAPTTPKEPAPTT 745



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 87/414 (21%), Positives = 130/414 (31%), Gaps = 44/414 (10%)

Query: 19  SPTGAGCPRPCADTPGP----QPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLA 74
           SPT    P P      P    +P P   +     P EP P  T        +        
Sbjct: 422 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK-------- 473

Query: 75  GLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILK 134
              +     P + +  TP       P+E           +     A +  K+  A    K
Sbjct: 474 ---EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKET-APTTPK 529

Query: 135 KQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLR---K 191
           K        + P +P  P  T  P E    T         P P+ P +P    P      
Sbjct: 530 KLTPTTPEKLAPTTPEKPAPTT-PEELAPTTPE------EPTPTTPEEPAPTTPKAAAPN 582

Query: 192 TVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSP 251
           T  EP      +P  +  +   P   KE+AP + +     TL + +P++   PA    +P
Sbjct: 583 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 642

Query: 252 NDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPL-FLPHGLEP----EAGGTLPS 306
             ++   +      A +  +      P+ P   +P  P    P G  P    E   T P 
Sbjct: 643 TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK 702

Query: 307 RLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPS 366
           +  P   L P+ +  P  T     P P    ++  TT          P     + P  P+
Sbjct: 703 KPAP-KELAPTTTKGPTSTTSD-KPAPTTPKETAPTT----------PKEPAPTTPKKPA 750

Query: 367 ATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEK-PRLRQIPSAEDLETDGGGPG 419
            T P  P P    +    T  +       P E  P L   P+ + LE     PG
Sbjct: 751 PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 804


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 112/554 (20%), Positives = 176/554 (31%), Gaps = 82/554 (14%)

Query: 3   SPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQ 62
           +P A+ T   P            P+  A T   +P P  ++     P EP P  T  A  
Sbjct: 291 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 350

Query: 63  RPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASS 122
            P+                 EP   +   P P     P          K+ +  +  ++ 
Sbjct: 351 TPK-----------------EPAPTTTKEPAPTTPKEPAPTTT-----KEPAPTTTKSAP 388

Query: 123 VVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSD 182
              ++ A    KK      +   P +P  P  T  P E    T+        P P+ P +
Sbjct: 389 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT-PKEPAPTTKE-------PAPTTPKE 440

Query: 183 PPEHFPLRK---TVSEPNLKLRYKPKKSLERRKNPLLRKESAP------PSLRRRPAETL 233
           P    P +    T  EP      +P  +  +  +P   KE AP      P+  + PA T 
Sbjct: 441 PAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 500

Query: 234 GDSSPSSSSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPL--- 290
             S+P++   P    S     E  P         + ++  PT  P+ P   +P  P    
Sbjct: 501 TKSAPTTPKEP----SPTTTKEPAPTTPKEPAPTTPKKPAPTT-PKEPAPTTPKEPAPTT 555

Query: 291 ------FLPHGLEP----EAGGTLPSRLQPIL--LLDPSGSHAPLLTVP-------GLGP 331
                   P    P    E   T P +L P     L P+    P  T P          P
Sbjct: 556 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP 615

Query: 332 LPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIK 391
            P    +   TT + +    + P     + P  P+ T P  P P  P+ E   T  +   
Sbjct: 616 TPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKEPAPTTPKEPAPTTPK-ETAPTTPKGTA 672

Query: 392 RSAKPSEKPRLRQIPSAEDL--ETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQ 449
            +      P   + P+ ++L   T         D        G      + PAP      
Sbjct: 673 PTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT----- 727

Query: 450 VLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSR--AQSSPAAPASLSAPEPASQARV 507
                 +  A   P+G+   T+  P      +P  +  A ++   P S ++ +PA     
Sbjct: 728 ----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPK 783

Query: 508 LSSSETPARTLPFT 521
            ++  TP    P T
Sbjct: 784 ETAPTTPKEPAPTT 797



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 87/414 (21%), Positives = 130/414 (31%), Gaps = 44/414 (10%)

Query: 19  SPTGAGCPRPCADTPGP----QPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLA 74
           SPT    P P      P    +P P   +     P EP P  T        +        
Sbjct: 474 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK-------- 525

Query: 75  GLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILK 134
              +     P + +  TP       P+E           +     A +  K+  A    K
Sbjct: 526 ---EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKET-APTTPK 581

Query: 135 KQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLR---K 191
           K        + P +P  P  T  P E    T         P P+ P +P    P      
Sbjct: 582 KLTPTTPEKLAPTTPEKPAPTT-PEELAPTTPE------EPTPTTPEEPAPTTPKAAAPN 634

Query: 192 TVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSP 251
           T  EP      +P  +  +   P   KE+AP + +     TL + +P++   PA    +P
Sbjct: 635 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 694

Query: 252 NDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPL-FLPHGLEP----EAGGTLPS 306
             ++   +      A +  +      P+ P   +P  P    P G  P    E   T P 
Sbjct: 695 TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK 754

Query: 307 RLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPS 366
           +  P   L P+ +  P  T     P P    ++  TT          P     + P  P+
Sbjct: 755 KPAP-KELAPTTTKGPTSTTSD-KPAPTTPKETAPTT----------PKEPAPTTPKKPA 802

Query: 367 ATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEK-PRLRQIPSAEDLETDGGGPG 419
            T P  P P    +    T  +       P E  P L   P+ + LE     PG
Sbjct: 803 PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 856


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 112/554 (20%), Positives = 176/554 (31%), Gaps = 82/554 (14%)

Query: 3   SPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQ 62
           +P A+ T   P            P+  A T   +P P  ++     P EP P  T  A  
Sbjct: 332 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 391

Query: 63  RPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASS 122
            P+                 EP   +   P P     P          K+ +  +  ++ 
Sbjct: 392 TPK-----------------EPAPTTTKEPAPTTPKEPAPTTT-----KEPAPTTTKSAP 429

Query: 123 VVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSD 182
              ++ A    KK      +   P +P  P  T  P E    T+        P P+ P +
Sbjct: 430 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT-PKEPAPTTKE-------PAPTTPKE 481

Query: 183 PPEHFPLRK---TVSEPNLKLRYKPKKSLERRKNPLLRKESAP------PSLRRRPAETL 233
           P    P +    T  EP      +P  +  +  +P   KE AP      P+  + PA T 
Sbjct: 482 PAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT 541

Query: 234 GDSSPSSSSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPL--- 290
             S+P++   P    S     E  P         + ++  PT  P+ P   +P  P    
Sbjct: 542 TKSAPTTPKEP----SPTTTKEPAPTTPKEPAPTTPKKPAPTT-PKEPAPTTPKEPAPTT 596

Query: 291 ------FLPHGLEP----EAGGTLPSRLQPIL--LLDPSGSHAPLLTVP-------GLGP 331
                   P    P    E   T P +L P     L P+    P  T P          P
Sbjct: 597 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP 656

Query: 332 LPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIK 391
            P    +   TT + +    + P     + P  P+ T P  P P  P+ E   T  +   
Sbjct: 657 TPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKEPAPTTPKEPAPTTPK-ETAPTTPKGTA 713

Query: 392 RSAKPSEKPRLRQIPSAEDL--ETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQ 449
            +      P   + P+ ++L   T         D        G      + PAP      
Sbjct: 714 PTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT----- 768

Query: 450 VLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSR--AQSSPAAPASLSAPEPASQARV 507
                 +  A   P+G+   T+  P      +P  +  A ++   P S ++ +PA     
Sbjct: 769 ----TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPK 824

Query: 508 LSSSETPARTLPFT 521
            ++  TP    P T
Sbjct: 825 ETAPTTPKEPAPTT 838



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 87/414 (21%), Positives = 130/414 (31%), Gaps = 44/414 (10%)

Query: 19  SPTGAGCPRPCADTPGP----QPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLA 74
           SPT    P P      P    +P P   +     P EP P  T        +        
Sbjct: 515 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK-------- 566

Query: 75  GLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILK 134
              +     P + +  TP       P+E           +     A +  K+  A    K
Sbjct: 567 ---EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKET-APTTPK 622

Query: 135 KQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLR---K 191
           K        + P +P  P  T  P E    T         P P+ P +P    P      
Sbjct: 623 KLTPTTPEKLAPTTPEKPAPTT-PEELAPTTPE------EPTPTTPEEPAPTTPKAAAPN 675

Query: 192 TVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSP 251
           T  EP      +P  +  +   P   KE+AP + +     TL + +P++   PA    +P
Sbjct: 676 TPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 735

Query: 252 NDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSPHTPL-FLPHGLEP----EAGGTLPS 306
             ++   +      A +  +      P+ P   +P  P    P G  P    E   T P 
Sbjct: 736 TTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK 795

Query: 307 RLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPS 366
           +  P   L P+ +  P  T     P P    ++  TT          P     + P  P+
Sbjct: 796 KPAP-KELAPTTTKGPTSTTSD-KPAPTTPKETAPTT----------PKEPAPTTPKKPA 843

Query: 367 ATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEK-PRLRQIPSAEDLETDGGGPG 419
            T P  P P    +    T  +       P E  P L   P+ + LE     PG
Sbjct: 844 PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 897


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 119/515 (23%), Positives = 168/515 (32%), Gaps = 81/515 (15%)

Query: 28   PCADTPGPQPQPMDLRVGQRPPVEPP--PEPTLLALQRPQ----------RLHHHLFLAG 75
            P A  P P    +   +  RP + P   P PTL   + P           +L H      
Sbjct: 1326 PLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEV 1385

Query: 76   LQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKK 135
                    P+ +S    +P    GP    +      + S  ++  SS V   L+  +   
Sbjct: 1386 SASAPGAAPLTISSPLHVPSSLPGPASSPMPI---PNSSPLASPVSSTVSVPLSSSLPIS 1442

Query: 136  QQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPP----VPSLPSDPPEHFPLRK 191
                L     P S  +      PL    +  ++L+S  PP    VP+ P  PP   P   
Sbjct: 1443 VPTTLPA---PASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPG-PPSLAPSGA 1498

Query: 192  TVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSP 251
            + S   L L      SL   + P      AP S       +    + S    PAS  +SP
Sbjct: 1499 SPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASP 1558

Query: 252  NDSEHGPNPILGSE-ADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQP 310
              S   P P   S  A +   +     P  P + +P T +  P    P         L P
Sbjct: 1559 FPSAPNPAPAQASLLAPASSASQALATPLAP-MAAPQTAILAPSPAPP---------LAP 1608

Query: 311  ILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAP 370
            + +L PS   AP+L      P+P     S   T   S S +  P     +  L PS+T  
Sbjct: 1609 LPVLAPSPGAAPVLA-SSQTPVPVMAPSSTPGTSLASASPVPAP-----TPVLAPSSTQT 1662

Query: 371  PPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRE 430
              P P+   L               P+    L   P+       G  P Q +        
Sbjct: 1663 MLPAPVPSPLPS-------------PASTQTLALAPALAPT-LGGSSPSQTLS------- 1701

Query: 431  LGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQ------GGHRPLS 484
            LG G P+  GP P Q                 P  S   T    L+       G  + LS
Sbjct: 1702 LGTGNPQ--GPFPTQT------------LSLTPASSLVPTPAQTLSLAPGPPLGPTQTLS 1747

Query: 485  RAQSSPAAPASLSAPEPASQARVLSSSETPARTLP 519
             A + P APAS   P PA    +  +S + +   P
Sbjct: 1748 LAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAP 1782



 Score = 37.4 bits (85), Expect = 0.067
 Identities = 63/240 (26%), Positives = 88/240 (36%), Gaps = 47/240 (19%)

Query: 175  PVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLL--------RKESAPPSLR 226
            P  SLP+ P + F  R+     +++L      S E     LL        R+   PP   
Sbjct: 2813 PSSSLPTPPQQPFIARR-----HIELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKN 2867

Query: 227  RRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSP 286
            R PA+  G     + S+   G ++  D   GP  ++ ++   + +  P   P GP     
Sbjct: 2868 RSPADA-GRGVDEAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHR 2926

Query: 287  HTPLFLP-----HGLEPEA-------------GGTLPSRLQPILLLDPSGSHAPLLTVPG 328
              PL  P      G  P+A              G   SR QP     P  S  PL  +P 
Sbjct: 2927 PNPLLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQP----PPHPS--PLTPLPP 2980

Query: 329  LGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQ-PRLEQLKTHV 387
            L   P     + +TT  +S S    P  R R  P       PP P P Q P L++  T V
Sbjct: 2981 LLVCPTATVANTVTTVTISTS----PPKRKRGRP----PKNPPSPRPSQLPVLDRDSTSV 3032



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 89/370 (24%), Positives = 121/370 (32%), Gaps = 76/370 (20%)

Query: 219  ESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGS---------EADSD 269
            ++  P+    P   L  S+PS++  P +G S P  +   P  ++ +         +A  D
Sbjct: 1261 QAVAPTPGPTPVSVLPSSTPSTTPAP-TGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRD 1319

Query: 270  RRTH-PTLGP--RGPILGSPHT----PLFLPHGLEPEAGGTL------PSRLQPILLLDP 316
              T  P L P  R P  G P      P   P  L     GT       P+ ++P+L L  
Sbjct: 1320 GLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVH 1379

Query: 317  SGSHAPLLTVPGLGPL----PFHFAQSLMTTERL-----SGSGLHWPLSRTRSEPLPPSA 367
            S S     + PG  PL    P H   SL           + S L  P+S T S PL  S 
Sbjct: 1380 SPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSL 1439

Query: 368  TAPPP---PGPMQPRLE-------QLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGG 417
                P   P P    L         +      +  S  P   P +   P    L   G  
Sbjct: 1440 PISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGAS 1499

Query: 418  P-------GQVVDDGLEHREL-GH------------GQPEARGPA-------------PL 444
            P       G      L   +  GH            G      PA             P 
Sbjct: 1500 PSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPF 1559

Query: 445  QQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQ 504
               P     +   LA          T L P+A      L+ + + P AP  + AP P + 
Sbjct: 1560 PSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGA- 1618

Query: 505  ARVLSSSETP 514
            A VL+SS+TP
Sbjct: 1619 APVLASSQTP 1628


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 72/238 (30%), Positives = 87/238 (36%), Gaps = 44/238 (18%)

Query: 174 PPVPSLPSDP-----PEHFPLRKTVSEPNLKLRYKPKKSLERRKN--PLLRKESA----- 221
           PPVP  P  P     P  FP  +  +     +R  P  S     N  PL    S      
Sbjct: 204 PPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDK 263

Query: 222 ----PPSLRRRPA---ETLGDSSPSSS-----STPASGCSS------PNDSEHGPNPILG 263
               PP +  RP+   E +    P ++     STP    SS      P  S  GP P+  
Sbjct: 264 PPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPP 323

Query: 264 SEADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLP---SRLQPILLLDPSGSH 320
           S + +D    P L  R   L S   PL       P   G LP   S   P  + DP G  
Sbjct: 324 SSSGNDET--PRLPQRNLSLSSSTPPL-----PSPGRSGPLPPPPSERPPPPVRDPPGRS 376

Query: 321 APLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPP---SATAPPPPGP 375
            PL   P +            T +  S SG+  P S  R  PLPP   SA APPPP P
Sbjct: 377 GPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRP-PLPPDRPSAGAPPPPPP 433


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 72/238 (30%), Positives = 87/238 (36%), Gaps = 44/238 (18%)

Query: 174 PPVPSLPSDP-----PEHFPLRKTVSEPNLKLRYKPKKSLERRKN--PLLRKESA----- 221
           PPVP  P  P     P  FP  +  +     +R  P  S     N  PL    S      
Sbjct: 204 PPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDK 263

Query: 222 ----PPSLRRRPA---ETLGDSSPSSS-----STPASGCSS------PNDSEHGPNPILG 263
               PP +  RP+   E +    P ++     STP    SS      P  S  GP P+  
Sbjct: 264 PPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPP 323

Query: 264 SEADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLP---SRLQPILLLDPSGSH 320
           S + +D    P L  R   L S   PL       P   G LP   S   P  + DP G  
Sbjct: 324 SSSGNDET--PRLPQRNLSLSSSTPPL-----PSPGRSGPLPPPPSERPPPPVRDPPGRS 376

Query: 321 APLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPP---SATAPPPPGP 375
            PL   P +            T +  S SG+  P S  R  PLPP   SA APPPP P
Sbjct: 377 GPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRP-PLPPDRPSAGAPPPPPP 433


>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 85/333 (25%), Positives = 106/333 (31%), Gaps = 31/333 (9%)

Query: 4   PGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQR 63
           P   G    P      P G G P P   +  P P P+ L     P + PPP P L AL  
Sbjct: 141 PPPPGPAPGPPQDISEPPG-GSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199

Query: 64  PQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSV 123
           P  L                P+      P P     P        +      R      V
Sbjct: 200 PHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTV----GTRLFPPGGV 255

Query: 124 VKQKLAEVILKKQQAALERTVHPNSPGIPY-RTLEPLETEGATRSMLSSFLPPVPSLPSD 182
            K K ++V L  +QA   R   P SP  P    L P      T        PP P     
Sbjct: 256 TKWK-SDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPV---- 310

Query: 183 PPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSS 242
                   +T S P  + +  P+K     K    R    PPS   RPA     S      
Sbjct: 311 --------RTSSIPVQEAQEAPRKEEGATKKAPSRL-PLPPSFHIRPA-----SQVYPDR 356

Query: 243 TPASGCSSPNDSEHGPNPILG-SEADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAG 301
            P   C     +    +P LG S++ +D R      P  P L  P  PL  P    P A 
Sbjct: 357 APEPDCPGELKATAPASPRLGQSQSQADERAGTP--PPAPPLPPPAPPLPPPAPPLPPAA 414

Query: 302 GTLPSRLQPILLLDPSG-SHAPLLTVPGLGPLP 333
             LP   +      P+G +  P  + P L P P
Sbjct: 415 PPLPCAQK--AAHPPAGFTKTPKSSSPALKPKP 445



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 89/382 (23%), Positives = 123/382 (32%), Gaps = 62/382 (16%)

Query: 172 FLPPVPSL----PSDPPEHFPLRKTVSEPN-LKLRYKPKKSLERRKNPLLRKESAPPSLR 226
           F+PP P L    P  PP   P     + P+ +  R  P   + + K+ +        +L 
Sbjct: 214 FIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDV--------ALN 265

Query: 227 RRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSP 286
            R AE    S P S + P      PN   H   P       S +   PT     P+  S 
Sbjct: 266 GRQAEATRASPPRSPAEPKGSALGPNPEPHLTFP------RSFKVPPPT-----PVRTSS 314

Query: 287 HTPLFLPHGLEPEAGGT--LPSRLQ--PILLLDPSGS----HAPLLTVPG----LGPLPF 334
                       E G T   PSRL   P   + P+       AP    PG      P   
Sbjct: 315 IPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASP 374

Query: 335 HFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSA 394
              QS    +  +G+    P     + PLPP A   PP  P  P   Q   H        
Sbjct: 375 RLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLP-CAQKAAHPPAGFTKT 433

Query: 395 KPSEKPRLRQIP-------SAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQH 447
             S  P L+  P       +A     D   P Q+  + L +    +     R    L   
Sbjct: 434 PKSSSPALKPKPNPPSPENTASSAPVDWRDPSQM--EKLRNELAAYLCGSRREDRFLSHR 491

Query: 448 PQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARV 507
           P   +  Q +   + PR    +T+L               S PA       PE +     
Sbjct: 492 PGPTVAPQSKEGKKGPRLPEKETLL---------------SLPAKDTPPGVPEKSLGGSS 536

Query: 508 LSSSE-TPARTLPFTTGLIYDS 528
           L+ +E  P+ TLP    +  DS
Sbjct: 537 LTETEAAPSLTLPSVDYIPQDS 558


>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 85/333 (25%), Positives = 106/333 (31%), Gaps = 31/333 (9%)

Query: 4   PGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQR 63
           P   G    P      P G G P P   +  P P P+ L     P + PPP P L AL  
Sbjct: 141 PPPPGPAPGPPQDISEPPG-GSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSP 199

Query: 64  PQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSV 123
           P  L                P+      P P     P        +      R      V
Sbjct: 200 PHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTV----GTRLFPPGGV 255

Query: 124 VKQKLAEVILKKQQAALERTVHPNSPGIPY-RTLEPLETEGATRSMLSSFLPPVPSLPSD 182
            K K ++V L  +QA   R   P SP  P    L P      T        PP P     
Sbjct: 256 TKWK-SDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPV---- 310

Query: 183 PPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSS 242
                   +T S P  + +  P+K     K    R    PPS   RPA     S      
Sbjct: 311 --------RTSSIPVQEAQEAPRKEEGATKKAPSRL-PLPPSFHIRPA-----SQVYPDR 356

Query: 243 TPASGCSSPNDSEHGPNPILG-SEADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAG 301
            P   C     +    +P LG S++ +D R      P  P L  P  PL  P    P A 
Sbjct: 357 APEPDCPGELKATAPASPRLGQSQSQADERAGTP--PPAPPLPPPAPPLPPPAPPLPPAA 414

Query: 302 GTLPSRLQPILLLDPSG-SHAPLLTVPGLGPLP 333
             LP   +      P+G +  P  + P L P P
Sbjct: 415 PPLPCAQK--AAHPPAGFTKTPKSSSPALKPKP 445



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 89/382 (23%), Positives = 123/382 (32%), Gaps = 62/382 (16%)

Query: 172 FLPPVPSL----PSDPPEHFPLRKTVSEPN-LKLRYKPKKSLERRKNPLLRKESAPPSLR 226
           F+PP P L    P  PP   P     + P+ +  R  P   + + K+ +        +L 
Sbjct: 214 FIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDV--------ALN 265

Query: 227 RRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEADSDRRTHPTLGPRGPILGSP 286
            R AE    S P S + P      PN   H   P       S +   PT     P+  S 
Sbjct: 266 GRQAEATRASPPRSPAEPKGSALGPNPEPHLTFP------RSFKVPPPT-----PVRTSS 314

Query: 287 HTPLFLPHGLEPEAGGT--LPSRLQ--PILLLDPSGS----HAPLLTVPG----LGPLPF 334
                       E G T   PSRL   P   + P+       AP    PG      P   
Sbjct: 315 IPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASP 374

Query: 335 HFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSA 394
              QS    +  +G+    P     + PLPP A   PP  P  P   Q   H        
Sbjct: 375 RLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLP-CAQKAAHPPAGFTKT 433

Query: 395 KPSEKPRLRQIP-------SAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQH 447
             S  P L+  P       +A     D   P Q+  + L +    +     R    L   
Sbjct: 434 PKSSSPALKPKPNPPSPENTASSAPVDWRDPSQM--EKLRNELAAYLCGSRREDRFLSHR 491

Query: 448 PQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARV 507
           P   +  Q +   + PR    +T+L               S PA       PE +     
Sbjct: 492 PGPTVAPQSKEGKKGPRLPEKETLL---------------SLPAKDTPPGVPEKSLGGSS 536

Query: 508 LSSSE-TPARTLPFTTGLIYDS 528
           L+ +E  P+ TLP    +  DS
Sbjct: 537 LTETEAAPSLTLPSVDYIPQDS 558


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,124,309
Number of Sequences: 37866
Number of extensions: 2849904
Number of successful extensions: 22015
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 700
Number of HSP's that attempted gapping in prelim test: 17699
Number of HSP's gapped (non-prelim): 4386
length of query: 954
length of database: 18,247,518
effective HSP length: 112
effective length of query: 842
effective length of database: 14,006,526
effective search space: 11793494892
effective search space used: 11793494892
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.