Guide to the Human Genome
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Search of human proteins with 14211943

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14211943 lysyl oxidase-like 3 precursor [Homo sapiens]
         (753 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14211943 lysyl oxidase-like 3 precursor [Homo sapiens]            1611   0.0  
gi|4505011 lysyl oxidase-like 2 precursor [Homo sapiens]              907   0.0  
gi|67782349 lysyl oxidase-like 4 precursor [Homo sapiens]             870   0.0  
gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens]     264   2e-70
gi|148539844 deleted in malignant brain tumors 1 isoform c precu...   264   2e-70
gi|148539842 deleted in malignant brain tumors 1 isoform b precu...   264   2e-70
gi|148539840 deleted in malignant brain tumors 1 isoform a precu...   264   2e-70
gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens]     261   2e-69
gi|20149540 lysyl oxidase preproprotein [Homo sapiens]                226   6e-59
gi|50659091 scavenger receptor cysteine-rich type 1 precursor [H...   226   8e-59
gi|18152779 scavenger receptor cysteine rich domain containing, ...   224   3e-58
gi|67782346 lysyl oxidase-like 1 preproprotein [Homo sapiens]         222   1e-57
gi|44889963 CD163 antigen isoform b [Homo sapiens]                    212   1e-54
gi|44662834 CD163 antigen isoform a [Homo sapiens]                    212   1e-54
gi|4506143 neurotrypsin precursor [Homo sapiens]                      211   3e-54
gi|222352122 hypothetical protein LOC284297 [Homo sapiens]            196   7e-50
gi|5174411 CD5 molecule-like [Homo sapiens]                           169   1e-41
gi|239752563 PREDICTED: hypothetical protein [Homo sapiens]           160   5e-39
gi|194018748 CD6 molecule [Homo sapiens]                              135   1e-31
gi|20357512 macrophage scavenger receptor 1 isoform type 1 [Homo...   109   8e-24
gi|5803080 macrophage receptor with collagenous structure [Homo ...   101   3e-21
gi|5031863 galectin 3 binding protein [Homo sapiens]                  100   4e-21
gi|47271477 scavenger receptor class A, member 5 [Homo sapiens]       100   8e-21
gi|187936955 HHIP-like protein 1 isoform a [Homo sapiens]             100   8e-21
gi|20357515 macrophage scavenger receptor 1 isoform type 3 [Homo...    55   3e-07
gi|166197668 CD5 molecule [Homo sapiens]                               44   4e-04
gi|119392081 complement factor I preproprotein [Homo sapiens]          40   0.008
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...    36   0.12 
gi|14602457 transmembrane protease, serine 3 isoform 3 [Homo sap...    36   0.12 
gi|239752583 PREDICTED: hypothetical protein XP_002348171 [Homo ...    35   0.34 

>gi|14211943 lysyl oxidase-like 3 precursor [Homo sapiens]
          Length = 753

 Score = 1611 bits (4172), Expect = 0.0
 Identities = 753/753 (100%), Positives = 753/753 (100%)

Query: 1   MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEI 60
           MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEI
Sbjct: 1   MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEI 60

Query: 61  QRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQS 120
           QRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQS
Sbjct: 61  QRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQS 120

Query: 121 VTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRR 180
           VTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRR
Sbjct: 121 VTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRR 180

Query: 181 PLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHS 240
           PLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHS
Sbjct: 181 PLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHS 240

Query: 241 FGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK 300
           FGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK
Sbjct: 241 FGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK 300

Query: 301 PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGA 360
           PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGA
Sbjct: 301 PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGA 360

Query: 361 RMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLS 420
           RMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLS
Sbjct: 361 RMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLS 420

Query: 421 GGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSG 480
           GGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSG
Sbjct: 421 GGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSG 480

Query: 481 NITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQE 540
           NITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQE
Sbjct: 481 NITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQE 540

Query: 541 TAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHS 600
           TAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHS
Sbjct: 541 TAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHS 600

Query: 601 WVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQ 660
           WVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQ
Sbjct: 601 WVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQ 660

Query: 661 GITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGH 720
           GITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGH
Sbjct: 661 GITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGH 720

Query: 721 RIWVHNCHIGDAFSEEANRRFERYPGQTSNQII 753
           RIWVHNCHIGDAFSEEANRRFERYPGQTSNQII
Sbjct: 721 RIWVHNCHIGDAFSEEANRRFERYPGQTSNQII 753


>gi|4505011 lysyl oxidase-like 2 precursor [Homo sapiens]
          Length = 774

 Score =  907 bits (2344), Expect = 0.0
 Identities = 413/727 (56%), Positives = 539/727 (74%), Gaps = 9/727 (1%)

Query: 33  PEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEAT 92
           P+  A    ++ RLAG  RK  EGRVE+   G+WGT+CDDDF++ AAH++CRELG+ EA 
Sbjct: 47  PQAPANVAKIQLRLAGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAK 106

Query: 93  GWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGF 152
            WT S+ YG G G IWLDNL C+G E ++  C S GWG +DC H ED GV+C D+R+PGF
Sbjct: 107 SWTASSSYGKGEGPIWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGF 166

Query: 153 SDSNVI--EVEH-HLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHN 209
              N +  ++E+ ++QVE++RIR  +   R+  PV EG VEV+    W Q+CDK W+A N
Sbjct: 167 KFDNSLINQIENLNIQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKN 226

Query: 210 SHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTA 269
           S VVCGM GFP E+  N   Y++ A R++  +    + C GTEAH+S C L    + D  
Sbjct: 227 SRVVCGMFGFPGERTYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPM 286

Query: 270 R---CPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKAS 326
           +   C  G PAVVSCVPG V++     + ++  KP+ +  VRL+GGA+ GEGRVEVLK  
Sbjct: 287 KNVTCENGLPAVVSCVPGQVFSPDGPSRFRKAYKPE-QPLVRLRGGAYIGEGRVEVLKNG 345

Query: 327 TWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKC 386
            WGTVCD KWDL +ASVVCRELGFGSA+EA++G+R+GQG+G IHL+E++C+G E S+  C
Sbjct: 346 EWGTVCDDKWDLVSASVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDC 405

Query: 387 PHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLIC 446
              N  ++ C+H +DAGVRCN P  G + ++RL+GGR+ +EGRVEV +   G L WG++C
Sbjct: 406 KF-NAESQGCNHEEDAGVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVC 464

Query: 447 GDDWGTLEAMVACRQLGLGYANHGLQETWYWDSG-NITEVVMSGVRCTGTELSLDQCAHH 505
           G +WG +EAMV CRQLGLG+A++  QETWYW    N  +VVMSGV+C+GTELSL  C H 
Sbjct: 465 GQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHD 524

Query: 506 GTHITCKRTGTRFTAGVICSETASDLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSA 565
           G  + C + G ++ AGV CSETA DL+L++ +VQ+T Y+EDRP+ ML CA EENCL++SA
Sbjct: 525 GEDVACPQGGVQYGAGVACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASA 584

Query: 566 RSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILTPN 625
              +   G+RRLLRFSSQIHN G++DFRPK GRH+W+WH+CH HYHSM++FTHYD+L  N
Sbjct: 585 AQTDPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLN 644

Query: 626 GTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDITDVK 685
           GTKVAEGHKASFCLEDTEC+ D+ K YECANFG+QGIT+GCWD+YRHDIDCQW+DITDV 
Sbjct: 645 GTKVAEGHKASFCLEDTECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVP 704

Query: 686 PGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEANRRFERYP 745
           PG+Y+ QVVINPNFEVAESD++NN MKC  +YDGHRIW++NCHIG +FSEE  ++FE + 
Sbjct: 705 PGDYLFQVVINPNFEVAESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFS 764

Query: 746 GQTSNQI 752
           G  +NQ+
Sbjct: 765 GLLNNQL 771


>gi|67782349 lysyl oxidase-like 4 precursor [Homo sapiens]
          Length = 756

 Score =  870 bits (2248), Expect = 0.0
 Identities = 418/762 (54%), Positives = 523/762 (68%), Gaps = 26/762 (3%)

Query: 9   WSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGT 68
           WSP   L   L    LG P PS  P+    +   + RL G   KP EGR+E+   G+WGT
Sbjct: 3   WSPPATLFLFLL--LLGQPPPSR-PQSLGTT---KLRLVGPESKPEEGRLEVLHQGQWGT 56

Query: 69  ICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRG 128
           +CDD+F +Q A + CR+LGF  A  W HSAKYG G G IWLDN+ C GTE S+ +C S G
Sbjct: 57  VCDDNFAIQEATVACRQLGFEAALTWAHSAKYGQGEGPIWLDNVRCVGTESSLDQCGSNG 116

Query: 129 WGNSDCTHDEDAGVICKDQRLPGFSDSNVIEV--EHHLQVEEVRIRPAVGWGRRPLPVTE 186
           WG SDC+H ED GVIC  +R  G+    V         ++EEVR++P +   ++  PVTE
Sbjct: 117 WGVSDCSHSEDVGVICHPRRHRGYLSETVSNALGPQGRRLEEVRLKPILASAKQHSPVTE 176

Query: 187 GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYR-------------LL 233
           G VEV+    W QVCD+GW+ +NS VVCGMLGFPSE  V++ +YR             L 
Sbjct: 177 GAVEVKYEGHWRQVCDQGWTMNNSRVVCGMLGFPSEVPVDSHYYRKVWDLKMRDPKSRLK 236

Query: 234 AQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTAR--CPGGGPAVVSCVPGPVYAASS 291
           +   ++SF +H V C+GTE H++ C ++   A    R  CPGG  AVVSCV GP +    
Sbjct: 237 SLTNKNSFWIHQVTCLGTEPHMANCQVQVAPARGKLRPACPGGMHAVVSCVAGPHFRPPK 296

Query: 292 GQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFG 351
             K Q++     E RVRL+ GA  GEGRVEVL    WGTVCD +W+L +ASVVCR+LGFG
Sbjct: 297 -TKPQRKGSWAEEPRVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFG 355

Query: 352 SAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYT 411
           SAREAL GAR+GQG+G IHLSEVRC G E +L  CP    +   C H  DA VRCN+P  
Sbjct: 356 SAREALFGARLGQGLGPIHLSEVRCRGYERTLSDCPALEGSQNGCQHENDAAVRCNVPNM 415

Query: 412 GAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGL 471
           G + ++RL+GGR   EG +EVQ+   G  RWG +C ++WG  EAMVACRQLGLG+A H  
Sbjct: 416 GFQNQVRLAGGRIPEEGLLEVQVEVNGVPRWGSVCSENWGLTEAMVACRQLGLGFAIHAY 475

Query: 472 QETWYWD-SGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASD 530
           +ETW+W  +    EVVMSGVRC+GTEL+L QC  HG  + C   G RF AGV C ++A D
Sbjct: 476 KETWFWSGTPRAQEVVMSGVRCSGTELALQQCQRHGP-VHCSHGGGRFLAGVSCMDSAPD 534

Query: 531 LLLHSALVQETAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRA 590
           L++++ LVQETAY+EDRPL  LYCA EENCL+ SA   +WPYG+RRLLRFS+QI+NLGR 
Sbjct: 535 LVMNAQLVQETAYLEDRPLSQLYCAHEENCLSKSADHMDWPYGYRRLLRFSTQIYNLGRT 594

Query: 591 DFRPKAGRHSWVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSK 650
           DFRPK GR SWVWH+CH HYHS+++FTHYD+LT NG+KVAEGHKASFCLEDT C   + +
Sbjct: 595 DFRPKTGRDSWVWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPTGLQR 654

Query: 651 RYECANFGEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNA 710
           RY CANFGEQG+TVGCWD YRHDIDCQW+DITDV PGNYI QV++NP++EVAESDF+NN 
Sbjct: 655 RYACANFGEQGVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNM 714

Query: 711 MKCNCKYDGHRIWVHNCHIGDAFSEEANRRFERYPGQTSNQI 752
           ++C CKYDGHR+W+HNCH G+++   A    E+     +N I
Sbjct: 715 LQCRCKYDGHRVWLHNCHTGNSYPANAELSLEQEQRLRNNLI 756


>gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens]
          Length = 1662

 Score =  264 bits (675), Expect = 2e-70
 Identities = 192/549 (34%), Positives = 249/549 (45%), Gaps = 72/549 (13%)

Query: 26  SPSPSTGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAH 80
           +PSP T P   A + G    LA     G  R   +GRVE+   G WGT+CDD +    A+
Sbjct: 341 TPSPDTWPTSHASTAGSESSLALRLVNGGDR--CQGRVEVLYRGSWGTVCDDSWDTSDAN 398

Query: 81  ILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDA 140
           ++CR+LG   AT    +A++G G+G I LD++ CSG E  +  C   GW + +C H EDA
Sbjct: 399 VVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDA 458

Query: 141 GVICKDQRL-----PGFSDSNVIEVEHHLQVEEVRIRPA-----VGWGRRPLPVTEGLVE 190
           GVIC          PG  D         L    V    +     V  G R     +G VE
Sbjct: 459 GVICSAAHSWSTPSPGERDRTDTLPTITLPASTVGSESSLALRLVNGGDR----CQGRVE 514

Query: 191 VRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGLHGVAC 248
           V     W  VCD  W  ++++VVC  LG  +      NA F      +      L  V C
Sbjct: 515 VLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARF-----GQGSGPIVLDDVRC 569

Query: 249 VGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEAR-- 306
            G E++L  C    + +++   C     A V C      AA S    +  + P   A   
Sbjct: 570 SGNESYLWSCPHNGWLSHN---CGHSEDAGVICS-----AAQSRSTPRPDTWPTSHASTA 621

Query: 307 -------VRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSG 359
                  +RL  G    +GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   
Sbjct: 622 GSESSLALRLVNGGDRCQGRVEVLYQGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGN 681

Query: 360 ARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNL----------- 408
           AR GQG G I L +VRCSG E  LW CPH    + +C HS+DAGV C+            
Sbjct: 682 ARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSPDT 741

Query: 409 -PYTGAET-------RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACR 460
            P + A T        +RL  G  +  GRVEV   G     WG +C D W T +A V CR
Sbjct: 742 WPTSRASTAGSESTLALRLVNGGDRCRGRVEVLYQG----SWGTVCDDYWDTNDANVVCR 797

Query: 461 QLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTA 520
           QLG G+A        +        +V+  VRC+G E  L  C H+G        G    A
Sbjct: 798 QLGCGWAMSAPGNAQFGQGSG--PIVLDDVRCSGHESYLWSCPHNGW--LSHNCGHHEDA 853

Query: 521 GVICSETAS 529
           GVICS   S
Sbjct: 854 GVICSAAQS 862



 Score =  257 bits (657), Expect = 2e-68
 Identities = 182/553 (32%), Positives = 249/553 (45%), Gaps = 64/553 (11%)

Query: 18  LLCSSCLGSPSPSTG-------------PEKKAGSQG-LRFRLAGFPRKPYEGRVEIQRA 63
           ++CS+     +PS G             P    GS+  L  RL     +  +GRVE+   
Sbjct: 460 VICSAAHSWSTPSPGERDRTDTLPTITLPASTVGSESSLALRLVNGGDR-CQGRVEVLYR 518

Query: 64  GEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTE 123
           G WGT+CDD +    A+++CR+LG   A     +A++G G+G I LD++ CSG E  +  
Sbjct: 519 GSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSGPIVLDDVRCSGNESYLWS 578

Query: 124 CASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQV---EEVRIRPAVGWGRR 180
           C   GW + +C H EDAGVIC   +       +     H         + +R   G  R 
Sbjct: 579 CPHNGWLSHNCGHSEDAGVICSAAQSRSTPRPDTWPTSHASTAGSESSLALRLVNGGDR- 637

Query: 181 PLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQ 238
                +G VEV     W  VCD  W  ++++VVC  LG  +      NA F      +  
Sbjct: 638 ----CQGRVEVLYQGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARF-----GQGS 688

Query: 239 HSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQ 298
               L  V C G E++L  C    + +++       G    +    P  +  +    +  
Sbjct: 689 GPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSPDTWPTSRAS 748

Query: 299 SK-PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREAL 357
           +   +    +RL  G     GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A 
Sbjct: 749 TAGSESTLALRLVNGGDRCRGRVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAP 808

Query: 358 SGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC----------- 406
             A+ GQG G I L +VRCSG E  LW CPH    + +C H +DAGV C           
Sbjct: 809 GNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSAAQSQSTPRP 868

Query: 407 ------NLPY--TGAETRI--RLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAM 456
                 NLP    G+E+ +  RL  G  +  GRVEV   G     WG +C D W T +A 
Sbjct: 869 DTWLTTNLPALTVGSESSLALRLVNGGDRCRGRVEVLYRGS----WGTVCDDSWDTNDAN 924

Query: 457 VACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG--THITCKRT 514
           V CRQLG G+A        +        +V+  VRC+G E  L  C H G  TH      
Sbjct: 925 VVCRQLGCGWAMSAPGNARFGQGSG--PIVLDDVRCSGNESYLWSCPHKGWLTH----NC 978

Query: 515 GTRFTAGVICSET 527
           G    AGVICS T
Sbjct: 979 GHHEDAGVICSAT 991



 Score =  251 bits (642), Expect = 1e-66
 Identities = 185/565 (32%), Positives = 253/565 (44%), Gaps = 59/565 (10%)

Query: 5   SVWQWSPWGLLLCLLCSSCLGS--PSPST--GPEKKAGSQGLRFRLAGFPRKPYEGRVEI 60
           +V + SP  L   L  +   GS  PS ST      +    GL  RL     +  +GRVEI
Sbjct: 59  TVAEGSPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGR-CQGRVEI 117

Query: 61  QRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQS 120
              G WGT+CDD +    A+++CR+LG   A     +A +G G+G I LD++ CSG E  
Sbjct: 118 LYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESY 177

Query: 121 VTECASRGWGNSDCTHDEDAGVICKDQRLPGF--SDSNVIEVEHHLQVE----EVRIRPA 174
           +  C   GW + +C H EDAGVIC   +       +S  + +   +  E     + +R  
Sbjct: 178 LWSCPHNGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLV 237

Query: 175 VGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRL 232
            G  R       G VEV     W  VCD  W  ++++VVC  LG  +      NA F   
Sbjct: 238 NGGDR-----CRGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQF--- 289

Query: 233 LAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSG 292
              +      L  V C G E++L  C    +  ++       G    +    P  +  + 
Sbjct: 290 --GQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNCGHSEDAGVICSAPQSRPTPSPDTW 347

Query: 293 QKKQQQSK-PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFG 351
                 +   +    +RL  G    +GRVEVL   +WGTVCD  WD   A+VVCR+LG G
Sbjct: 348 PTSHASTAGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTSDANVVCRQLGCG 407

Query: 352 SAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYT 411
            A  A   AR GQG G I L +VRCSG E  LW CPH    + +C HS+DAGV C+  ++
Sbjct: 408 WATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDAGVICSAAHS 467

Query: 412 -------------------------GAET--RIRLSGGRSQHEGRVEVQIGGPGPLRWGL 444
                                    G+E+   +RL  G  + +GRVEV   G     WG 
Sbjct: 468 WSTPSPGERDRTDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYRG----SWGT 523

Query: 445 ICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAH 504
           +C D W T +A V CRQLG G+A        +        +V+  VRC+G E  L  C H
Sbjct: 524 VCDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSG--PIVLDDVRCSGNESYLWSCPH 581

Query: 505 HGTHITCKRTGTRFTAGVICSETAS 529
           +G        G    AGVICS   S
Sbjct: 582 NGW--LSHNCGHSEDAGVICSAAQS 604



 Score =  208 bits (530), Expect = 1e-53
 Identities = 142/415 (34%), Positives = 190/415 (45%), Gaps = 31/415 (7%)

Query: 18  LLCSSCLG--SPSPSTGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTIC 70
           ++CS+     +P P T P   A + G    LA     G  R   +GRVE+   G WGT+C
Sbjct: 597 VICSAAQSRSTPRPDTWPTSHASTAGSESSLALRLVNGGDR--CQGRVEVLYQGSWGTVC 654

Query: 71  DDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWG 130
           DD +    A+++CR+LG   A     +A++G G+G I LD++ CSG E  +  C   GW 
Sbjct: 655 DDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWL 714

Query: 131 NSDCTHDEDAGVICK--DQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGL 188
           + +C H EDAGVIC     R     D+           E       V  G R      G 
Sbjct: 715 SHNCGHSEDAGVICSASQSRPTPSPDTWPTSRASTAGSESTLALRLVNGGDR----CRGR 770

Query: 189 VEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGLHGV 246
           VEV     W  VCD  W  ++++VVC  LG  +      NA F      +      L  V
Sbjct: 771 VEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQF-----GQGSGPIVLDDV 825

Query: 247 ACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKP----- 301
            C G E++L  C    + +++   C     A V C      +          + P     
Sbjct: 826 RCSGHESYLWSCPHNGWLSHN---CGHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVG 882

Query: 302 -QGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGA 360
            +    +RL  G     GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   A
Sbjct: 883 SESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNA 942

Query: 361 RMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAET 415
           R GQG G I L +VRCSG E  LW CPHK     +C H +DAGV C+     + T
Sbjct: 943 RFGQGSGPIVLDDVRCSGNESYLWSCPHKGWLTHNCGHHEDAGVICSATQINSTT 997



 Score =  107 bits (266), Expect = 5e-23
 Identities = 46/94 (48%), Positives = 63/94 (67%)

Query: 56   GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
            GRVEI   G WGT+CDD +T+Q A ++CR+LG   A     +A +G G+G I LD++ CS
Sbjct: 1146 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECS 1205

Query: 116  GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRL 149
            GTE ++ +C +RGW + +C H EDAGVIC    L
Sbjct: 1206 GTESTLWQCRNRGWFSHNCNHREDAGVICSGNHL 1239



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 44/90 (48%), Positives = 57/90 (63%)

Query: 318  GRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCS 377
            GRVE+    TWGTVCD  W +  A VVCR+LG G A  AL  A  G G G I L +V CS
Sbjct: 1146 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECS 1205

Query: 378  GQELSLWKCPHKNITAEDCSHSQDAGVRCN 407
            G E +LW+C ++   + +C+H +DAGV C+
Sbjct: 1206 GTESTLWQCRNRGWFSHNCNHREDAGVICS 1235



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 41/98 (41%), Positives = 50/98 (51%), Gaps = 8/98 (8%)

Query: 428  GRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVM 487
            GRVE+  GG     WG +C D W   EA V CRQLG G A   L    Y+ SG+   + +
Sbjct: 1146 GRVEIYHGGT----WGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNA-YFGSGS-GPITL 1199

Query: 488  SGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICS 525
              V C+GTE +L QC + G          R  AGVICS
Sbjct: 1200 DDVECSGTESTLWQCRNRGWF--SHNCNHREDAGVICS 1235



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 23/72 (31%), Positives = 28/72 (38%), Gaps = 3/72 (4%)

Query: 187  GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGV 246
            G VE+     W  VCD  W+   + VVC  LG     R  +A              L  V
Sbjct: 1146 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGC---GRAVSALGNAYFGSGSGPITLDDV 1202

Query: 247  ACVGTEAHLSLC 258
             C GTE+ L  C
Sbjct: 1203 ECSGTESTLWQC 1214


>gi|148539844 deleted in malignant brain tumors 1 isoform c precursor
            [Homo sapiens]
          Length = 2403

 Score =  264 bits (675), Expect = 2e-70
 Identities = 180/536 (33%), Positives = 245/536 (45%), Gaps = 52/536 (9%)

Query: 26   SPSPSTGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAH 80
            +PSP T P   A + G    LA     G  R   +GRVE+   G WGT+CDD +    A+
Sbjct: 830  TPSPDTWPTSHASTAGPESSLALRLVNGGDR--CQGRVEVLYRGSWGTVCDDSWDTSDAN 887

Query: 81   ILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDA 140
            ++CR+LG   AT    +A++G G+G I LD++ CSG E  +  C   GW + +C H EDA
Sbjct: 888  VVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDA 947

Query: 141  GVICKDQRL-----PGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPD 195
            GVIC          P    +  +          + +R   G  R      +G VEV    
Sbjct: 948  GVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDR-----CQGRVEVLYQG 1002

Query: 196  GWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEA 253
             W  VCD  W  ++++VVC  LG  +      NA F      +      L  V C G E+
Sbjct: 1003 SWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARF-----GQGSGPIVLDDVRCSGHES 1057

Query: 254  HLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK-PQGEARVRLKGG 312
            +L  C    + +++       G    +    P  +  +       +   +    +RL  G
Sbjct: 1058 YLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNG 1117

Query: 313  AHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLS 372
                +GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   AR GQG G I L 
Sbjct: 1118 GDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLD 1177

Query: 373  EVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNL------------PYTGAET----- 415
            +VRCSG E  LW CPH    + +C H +DAGV C+             P + A T     
Sbjct: 1178 DVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSES 1237

Query: 416  --RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQE 473
               +RL  G  + +GRVEV   G     WG +C D W T +A V CRQLG G+A      
Sbjct: 1238 SLALRLVNGGDRCQGRVEVLYRG----SWGTVCDDYWDTNDANVVCRQLGCGWATSAPGN 1293

Query: 474  TWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETAS 529
              +        +V+  VRC+G E  L  C H+G        G    AGVICS + S
Sbjct: 1294 ARFGQGSG--PIVLDDVRCSGHESYLWSCPHNGW--LSHNCGHHEDAGVICSASQS 1345



 Score =  264 bits (675), Expect = 2e-70
 Identities = 185/546 (33%), Positives = 252/546 (46%), Gaps = 58/546 (10%)

Query: 18   LLCSSCLGSPSPS--TGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTIC 70
            ++CS+    P+PS  T P   A + G    LA     G  R   +GRVE+   G WGT+C
Sbjct: 1209 VICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDR--CQGRVEVLYRGSWGTVC 1266

Query: 71   DDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWG 130
            DD +    A+++CR+LG   AT    +A++G G+G I LD++ CSG E  +  C   GW 
Sbjct: 1267 DDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWL 1326

Query: 131  NSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQV---EEVRIRPAVGWGRRPLPVTEG 187
            + +C H EDAGVIC   +       +     H         + +R   G  R      +G
Sbjct: 1327 SHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDR-----CQG 1381

Query: 188  LVEVRLPDGWSQVCDKGWSAHNSHVVCGML--GFPSEKRVNAAFYRLLAQRQQHSFGLHG 245
             VEV     W  VCD  W  ++++VVC  L  G+ +    NA F      +      L  
Sbjct: 1382 RVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARF-----GQGSGPIVLDD 1436

Query: 246  VACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASS-GQKKQQQSKPQGE 304
            V C G E++L  C    + +++       G    +    P  +  +    +   +  +  
Sbjct: 1437 VRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSRASTAGSEST 1496

Query: 305  ARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQ 364
              +RL  G     GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   A+ GQ
Sbjct: 1497 LALRLVNGGDRCRGRVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQFGQ 1556

Query: 365  GMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC-----------------N 407
            G G I L +VRCSG E  LW CPH    + +C H +DAGV C                 N
Sbjct: 1557 GSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSAAQSQSTPRPDTWLTTN 1616

Query: 408  LP--YTGAET--RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLG 463
            LP    G+E+   +RL  G  +  GRVEV   G     WG +C D W T +A V CRQLG
Sbjct: 1617 LPALTVGSESSLALRLVNGGDRCRGRVEVLYRG----SWGTVCDDSWDTNDANVVCRQLG 1672

Query: 464  LGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG--THITCKRTGTRFTAG 521
             G+A        +        +V+  VRC+G E  L  C H G  TH      G    AG
Sbjct: 1673 CGWAMSAPGNARFGQGSG--PIVLDDVRCSGNESYLWSCPHKGWLTH----NCGHHEDAG 1726

Query: 522  VICSET 527
            VICS T
Sbjct: 1727 VICSAT 1732



 Score =  263 bits (672), Expect = 4e-70
 Identities = 176/507 (34%), Positives = 234/507 (46%), Gaps = 35/507 (6%)

Query: 28  SPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELG 87
           SP    E    S  LR    G       GRVE+   G WGT+CDD +    A+++CR+LG
Sbjct: 220 SPPVPTEGSESSLALRLVNGG---DRCRGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLG 276

Query: 88  FTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQ 147
              A     +A++G G+G I LD++ CSG E  +  C   GW   +C H EDAGVIC   
Sbjct: 277 CGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNCGHSEDAGVICSAP 336

Query: 148 RLPGFSDSNVIEVEHHLQV---EEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKG 204
           +       +     H         + +R   G  R      +G VEV     W  VCD  
Sbjct: 337 QSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDR-----CQGRVEVLYRGSWGTVCDDS 391

Query: 205 WSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEF 262
           W   +++VVC  LG  + +    NA F      +      L  V C G E++L  C    
Sbjct: 392 WDTSDANVVCRQLGCGWATSAPGNARF-----GQGSGPIVLDDVRCSGYESYLWSCPHNG 446

Query: 263 YRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEV 322
           + +++       G      +P     AS+   +   +       +RL  G    +GRVEV
Sbjct: 447 WLSHNCQHSEDAGVICSDTLPTITLPASTVGSESSLA-------LRLVNGGDRCQGRVEV 499

Query: 323 LKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELS 382
           L   +WGTVCD  WD + A+VVCR+LG G A  A   AR GQG G I L +VRCSG E  
Sbjct: 500 LYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSGPIVLDDVRCSGNESY 559

Query: 383 LWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRW 442
           LW CPH    + +C HS+DAGV C+ P +    R+   G R Q  GRVEV   G     W
Sbjct: 560 LWSCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQ--GRVEVLYRG----SW 613

Query: 443 GLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQC 502
           G +C D W T +A V CRQLG G+A        +        +V+  VRC+G E  L  C
Sbjct: 614 GTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSG--PIVLDDVRCSGHESYLWSC 671

Query: 503 AHHGTHITCKRTGTRFTAGVICSETAS 529
            ++G        G    AGVICS   S
Sbjct: 672 PNNGW--LSHNCGHHEDAGVICSAAQS 696



 Score =  262 bits (670), Expect = 8e-70
 Identities = 172/504 (34%), Positives = 240/504 (47%), Gaps = 47/504 (9%)

Query: 55   EGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSC 114
            +GRVE+   G WGT+CDD +    A+++CR+LG   AT    +A++G G+G I LD++ C
Sbjct: 602  QGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 661

Query: 115  SGTEQSVTECASRGWGNSDCTHDEDAGVIC---KDQRLPGFSDSNVIEVEHHLQVEE--V 169
            SG E  +  C + GW + +C H EDAGVIC   + +  P     + I +       E  +
Sbjct: 662  SGHESYLWSCPNNGWLSHNCGHHEDAGVICSAAQSRSTPRPDTLSTITLPPSTVGSESSL 721

Query: 170  RIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNA 227
             +R   G  R      +G VEV     W  VCD  W  ++++VVC  LG  + +    NA
Sbjct: 722  TLRLVNGSDR-----CQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNA 776

Query: 228  AFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVY 287
             F      +      L  V C G E++L  C    + +++       G         P  
Sbjct: 777  RF-----GQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSVSQSRPTP 831

Query: 288  AASSGQKKQQQSK-PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCR 346
            +  +       +  P+    +RL  G    +GRVEVL   +WGTVCD  WD   A+VVCR
Sbjct: 832  SPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTSDANVVCR 891

Query: 347  ELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC 406
            +LG G A  A   AR GQG G I L +VRCSG E  LW CPH    + +C HS+DAGV C
Sbjct: 892  QLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDAGVIC 951

Query: 407  NLPYT-------------------GAET--RIRLSGGRSQHEGRVEVQIGGPGPLRWGLI 445
            +  ++                   G+E+   +RL  G  + +GRVEV   G     WG +
Sbjct: 952  SAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYQG----SWGTV 1007

Query: 446  CGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHH 505
            C D W T +A V CRQLG G+A        +        +V+  VRC+G E  L  C H+
Sbjct: 1008 CDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSG--PIVLDDVRCSGHESYLWSCPHN 1065

Query: 506  GTHITCKRTGTRFTAGVICSETAS 529
            G        G    AGVICS + S
Sbjct: 1066 GW--LSHNCGHSEDAGVICSASQS 1087



 Score =  262 bits (669), Expect = 1e-69
 Identities = 190/553 (34%), Positives = 257/553 (46%), Gaps = 43/553 (7%)

Query: 5   SVWQWSPWGLLLCLLCSSCLGS--PSPST--GPEKKAGSQGLRFRLAGFPRKPYEGRVEI 60
           +V + SP  L   L  +   GS  PS ST      +    GL  RL     +  +GRVEI
Sbjct: 59  TVAEGSPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGR-CQGRVEI 117

Query: 61  QRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQS 120
              G WGT+CDD +    A+++CR+LG   A     +A +G G+G I LD++ CSG E  
Sbjct: 118 LYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESY 177

Query: 121 VTECASRGWGNSDCTHDEDAGVICKDQRLPGF--SDSNVIEVEHHLQVE----EVRIRPA 174
           +  C   GW + +C H EDAGVIC   +       +S  + +   +  E     + +R  
Sbjct: 178 LWSCPHNGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLV 237

Query: 175 VGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGML--GFPSEKRVNAAFYRL 232
            G  R       G VEV     W  VCD  W  ++++VVC  L  G+      NA F   
Sbjct: 238 NGGDR-----CRGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQF--- 289

Query: 233 LAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSG 292
              +      L  V C G E++L  C    +  ++       G    +    P  +  + 
Sbjct: 290 --GQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNCGHSEDAGVICSAPQSRPTPSPDTW 347

Query: 293 QKKQQQSK-PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFG 351
                 +  P+    +RL  G    +GRVEVL   +WGTVCD  WD   A+VVCR+LG G
Sbjct: 348 PTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTSDANVVCRQLGCG 407

Query: 352 SAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCN---- 407
            A  A   AR GQG G I L +VRCSG E  LW CPH    + +C HS+DAGV C+    
Sbjct: 408 WATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDAGVICSDTLP 467

Query: 408 ---LPYT--GAET--RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACR 460
              LP +  G+E+   +RL  G  + +GRVEV   G     WG +C D W T +A V CR
Sbjct: 468 TITLPASTVGSESSLALRLVNGGDRCQGRVEVLYRG----SWGTVCDDSWDTNDANVVCR 523

Query: 461 QLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTA 520
           QLG G+A        +        +V+  VRC+G E  L  C H+G        G    A
Sbjct: 524 QLGCGWAMLAPGNARFGQGSG--PIVLDDVRCSGNESYLWSCPHNGW--LSHNCGHSEDA 579

Query: 521 GVICSETASDLLL 533
           GVICS   S L L
Sbjct: 580 GVICSGPESSLAL 592



 Score =  261 bits (666), Expect = 2e-69
 Identities = 181/544 (33%), Positives = 248/544 (45%), Gaps = 52/544 (9%)

Query: 18   LLCSSCLG--SPSPSTGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTIC 70
            ++CS+     +PSP T P   A + G    LA     G  R   +GRVE+   G WGT+C
Sbjct: 1080 VICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNGGDR--CQGRVEVLYRGSWGTVC 1137

Query: 71   DDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWG 130
            DD +    A+++CR+LG   A     +A++G G+G I LD++ CSG E  +  C   GW 
Sbjct: 1138 DDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWL 1197

Query: 131  NSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQV---EEVRIRPAVGWGRRPLPVTEG 187
            + +C H EDAGVIC   +       +     H         + +R   G  R      +G
Sbjct: 1198 SHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDR-----CQG 1252

Query: 188  LVEVRLPDGWSQVCDKGWSAHNSHVVCGML--GFPSEKRVNAAFYRLLAQRQQHSFGLHG 245
             VEV     W  VCD  W  ++++VVC  L  G+ +    NA F      +      L  
Sbjct: 1253 RVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARF-----GQGSGPIVLDD 1307

Query: 246  VACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK-PQGE 304
            V C G E++L  C    + +++       G    +    P  +  +       +   +  
Sbjct: 1308 VRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESS 1367

Query: 305  ARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQ 364
              +RL  G    +GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   AR GQ
Sbjct: 1368 LALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQ 1427

Query: 365  GMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNL------------PYTG 412
            G G I L +VRCSG E  LW CPH    + +C H +DAGV C+             P + 
Sbjct: 1428 GSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSR 1487

Query: 413  AET-------RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLG 465
            A T        +RL  G  +  GRVEV   G     WG +C D W T +A V CRQLG G
Sbjct: 1488 ASTAGSESTLALRLVNGGDRCRGRVEVLYQG----SWGTVCDDYWDTNDANVVCRQLGCG 1543

Query: 466  YANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICS 525
            +A        +        +V+  VRC+G E  L  C H+G        G    AGVICS
Sbjct: 1544 WAMSAPGNAQFGQGSG--PIVLDDVRCSGHESYLWSCPHNGW--LSHNCGHHEDAGVICS 1599

Query: 526  ETAS 529
               S
Sbjct: 1600 AAQS 1603



 Score =  211 bits (538), Expect = 2e-54
 Identities = 143/416 (34%), Positives = 193/416 (46%), Gaps = 33/416 (7%)

Query: 18   LLCSSCLGSPSPS--TGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTIC 70
            ++CS+    P+PS  T P   A + G    LA     G  R   +GRVE+   G WGT+C
Sbjct: 1338 VICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDR--CQGRVEVLYRGSWGTVC 1395

Query: 71   DDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWG 130
            DD +    A+++CR+LG   AT    +A++G G+G I LD++ CSG E  +  C   GW 
Sbjct: 1396 DDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWL 1455

Query: 131  NSDCTHDEDAGVIC---KDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEG 187
            + +C H EDAGVIC   + Q  P                  + +R   G  R       G
Sbjct: 1456 SHNCGHHEDAGVICSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDR-----CRG 1510

Query: 188  LVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGLHG 245
             VEV     W  VCD  W  ++++VVC  LG  +      NA F      +      L  
Sbjct: 1511 RVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQF-----GQGSGPIVLDD 1565

Query: 246  VACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKP---- 301
            V C G E++L  C    + +++   C     A V C      +          + P    
Sbjct: 1566 VRCSGHESYLWSCPHNGWLSHN---CGHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTV 1622

Query: 302  --QGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSG 359
              +    +RL  G     GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   
Sbjct: 1623 GSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGN 1682

Query: 360  ARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAET 415
            AR GQG G I L +VRCSG E  LW CPHK     +C H +DAGV C+     + T
Sbjct: 1683 ARFGQGSGPIVLDDVRCSGNESYLWSCPHKGWLTHNCGHHEDAGVICSATQINSTT 1738



 Score =  190 bits (482), Expect = 5e-48
 Identities = 128/380 (33%), Positives = 175/380 (46%), Gaps = 42/380 (11%)

Query: 186 EGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGL 243
           +G VE+     W  VCD  W  ++++VVC  LG  +      NA F      +      L
Sbjct: 112 QGRVEILYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWF-----GQGSGPIAL 166

Query: 244 HGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKP-- 301
             V C G E++L  C    + +++       G    +  P       S   +     P  
Sbjct: 167 DDVRCSGHESYLWSCPHNGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTE 226

Query: 302 --QGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSG 359
             +    +RL  G     GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   
Sbjct: 227 GSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGN 286

Query: 360 ARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYT-------- 411
           A+ GQG G I L +VRCSG E  LW CPH      +C HS+DAGV C+ P +        
Sbjct: 287 AQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNCGHSEDAGVICSAPQSRPTPSPDT 346

Query: 412 ---------GAETRI--RLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACR 460
                    G E+ +  RL  G  + +GRVEV   G     WG +C D W T +A V CR
Sbjct: 347 WPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGS----WGTVCDDSWDTSDANVVCR 402

Query: 461 QLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG--THITCKRTGTRF 518
           QLG G+A        +        +V+  VRC+G E  L  C H+G  +H  C+ +    
Sbjct: 403 QLGCGWATSAPGNARFGQGSG--PIVLDDVRCSGYESYLWSCPHNGWLSH-NCQHSED-- 457

Query: 519 TAGVICSETASDLLLHSALV 538
            AGVICS+T   + L ++ V
Sbjct: 458 -AGVICSDTLPTITLPASTV 476



 Score =  107 bits (266), Expect = 5e-23
 Identities = 46/94 (48%), Positives = 63/94 (67%)

Query: 56   GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
            GRVEI   G WGT+CDD +T+Q A ++CR+LG   A     +A +G G+G I LD++ CS
Sbjct: 1887 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECS 1946

Query: 116  GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRL 149
            GTE ++ +C +RGW + +C H EDAGVIC    L
Sbjct: 1947 GTESTLWQCRNRGWFSHNCNHREDAGVICSGNHL 1980



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 44/90 (48%), Positives = 57/90 (63%)

Query: 318  GRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCS 377
            GRVE+    TWGTVCD  W +  A VVCR+LG G A  AL  A  G G G I L +V CS
Sbjct: 1887 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECS 1946

Query: 378  GQELSLWKCPHKNITAEDCSHSQDAGVRCN 407
            G E +LW+C ++   + +C+H +DAGV C+
Sbjct: 1947 GTESTLWQCRNRGWFSHNCNHREDAGVICS 1976



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 41/98 (41%), Positives = 50/98 (51%), Gaps = 8/98 (8%)

Query: 428  GRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVM 487
            GRVE+  GG     WG +C D W   EA V CRQLG G A   L    Y+ SG+   + +
Sbjct: 1887 GRVEIYHGGT----WGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNA-YFGSGS-GPITL 1940

Query: 488  SGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICS 525
              V C+GTE +L QC + G          R  AGVICS
Sbjct: 1941 DDVECSGTESTLWQCRNRGWF--SHNCNHREDAGVICS 1976



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 23/72 (31%), Positives = 28/72 (38%), Gaps = 3/72 (4%)

Query: 187  GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGV 246
            G VE+     W  VCD  W+   + VVC  LG     R  +A              L  V
Sbjct: 1887 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGC---GRAVSALGNAYFGSGSGPITLDDV 1943

Query: 247  ACVGTEAHLSLC 258
             C GTE+ L  C
Sbjct: 1944 ECSGTESTLWQC 1955


>gi|148539842 deleted in malignant brain tumors 1 isoform b precursor
            [Homo sapiens]
          Length = 2413

 Score =  264 bits (675), Expect = 2e-70
 Identities = 180/536 (33%), Positives = 245/536 (45%), Gaps = 52/536 (9%)

Query: 26   SPSPSTGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAH 80
            +PSP T P   A + G    LA     G  R   +GRVE+   G WGT+CDD +    A+
Sbjct: 840  TPSPDTWPTSHASTAGPESSLALRLVNGGDR--CQGRVEVLYRGSWGTVCDDSWDTSDAN 897

Query: 81   ILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDA 140
            ++CR+LG   AT    +A++G G+G I LD++ CSG E  +  C   GW + +C H EDA
Sbjct: 898  VVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDA 957

Query: 141  GVICKDQRL-----PGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPD 195
            GVIC          P    +  +          + +R   G  R      +G VEV    
Sbjct: 958  GVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDR-----CQGRVEVLYQG 1012

Query: 196  GWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEA 253
             W  VCD  W  ++++VVC  LG  +      NA F      +      L  V C G E+
Sbjct: 1013 SWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARF-----GQGSGPIVLDDVRCSGHES 1067

Query: 254  HLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK-PQGEARVRLKGG 312
            +L  C    + +++       G    +    P  +  +       +   +    +RL  G
Sbjct: 1068 YLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNG 1127

Query: 313  AHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLS 372
                +GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   AR GQG G I L 
Sbjct: 1128 GDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLD 1187

Query: 373  EVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNL------------PYTGAET----- 415
            +VRCSG E  LW CPH    + +C H +DAGV C+             P + A T     
Sbjct: 1188 DVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSES 1247

Query: 416  --RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQE 473
               +RL  G  + +GRVEV   G     WG +C D W T +A V CRQLG G+A      
Sbjct: 1248 SLALRLVNGGDRCQGRVEVLYRG----SWGTVCDDYWDTNDANVVCRQLGCGWATSAPGN 1303

Query: 474  TWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETAS 529
              +        +V+  VRC+G E  L  C H+G        G    AGVICS + S
Sbjct: 1304 ARFGQGSG--PIVLDDVRCSGHESYLWSCPHNGW--LSHNCGHHEDAGVICSASQS 1355



 Score =  264 bits (675), Expect = 2e-70
 Identities = 185/546 (33%), Positives = 252/546 (46%), Gaps = 58/546 (10%)

Query: 18   LLCSSCLGSPSPS--TGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTIC 70
            ++CS+    P+PS  T P   A + G    LA     G  R   +GRVE+   G WGT+C
Sbjct: 1219 VICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDR--CQGRVEVLYRGSWGTVC 1276

Query: 71   DDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWG 130
            DD +    A+++CR+LG   AT    +A++G G+G I LD++ CSG E  +  C   GW 
Sbjct: 1277 DDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWL 1336

Query: 131  NSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQV---EEVRIRPAVGWGRRPLPVTEG 187
            + +C H EDAGVIC   +       +     H         + +R   G  R      +G
Sbjct: 1337 SHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDR-----CQG 1391

Query: 188  LVEVRLPDGWSQVCDKGWSAHNSHVVCGML--GFPSEKRVNAAFYRLLAQRQQHSFGLHG 245
             VEV     W  VCD  W  ++++VVC  L  G+ +    NA F      +      L  
Sbjct: 1392 RVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARF-----GQGSGPIVLDD 1446

Query: 246  VACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASS-GQKKQQQSKPQGE 304
            V C G E++L  C    + +++       G    +    P  +  +    +   +  +  
Sbjct: 1447 VRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSRASTAGSEST 1506

Query: 305  ARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQ 364
              +RL  G     GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   A+ GQ
Sbjct: 1507 LALRLVNGGDRCRGRVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQFGQ 1566

Query: 365  GMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC-----------------N 407
            G G I L +VRCSG E  LW CPH    + +C H +DAGV C                 N
Sbjct: 1567 GSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSAAQSQSTPRPDTWLTTN 1626

Query: 408  LP--YTGAET--RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLG 463
            LP    G+E+   +RL  G  +  GRVEV   G     WG +C D W T +A V CRQLG
Sbjct: 1627 LPALTVGSESSLALRLVNGGDRCRGRVEVLYRG----SWGTVCDDSWDTNDANVVCRQLG 1682

Query: 464  LGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG--THITCKRTGTRFTAG 521
             G+A        +        +V+  VRC+G E  L  C H G  TH      G    AG
Sbjct: 1683 CGWAMSAPGNARFGQGSG--PIVLDDVRCSGNESYLWSCPHKGWLTH----NCGHHEDAG 1736

Query: 522  VICSET 527
            VICS T
Sbjct: 1737 VICSAT 1742



 Score =  262 bits (670), Expect = 8e-70
 Identities = 178/513 (34%), Positives = 236/513 (46%), Gaps = 37/513 (7%)

Query: 28  SPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELG 87
           SP    E    S  LR    G       GRVE+   G WGT+CDD +    A+++CR+LG
Sbjct: 220 SPPVPTEGSESSLALRLVNGG---DRCRGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLG 276

Query: 88  FTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQ 147
              A     +A++G G+G I LD++ CSG E  +  C   GW   +C H EDAGVIC   
Sbjct: 277 CGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNCGHSEDAGVICSAP 336

Query: 148 RLPGFSDSNVIEVEHHLQV---EEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKG 204
           +       +     H         + +R   G  R      +G VEV     W  VCD  
Sbjct: 337 QSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDR-----CQGRVEVLYRGSWGTVCDDS 391

Query: 205 WSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEF 262
           W   +++VVC  LG  + +    NA F      +      L  V C G E++L  C    
Sbjct: 392 WDTSDANVVCRQLGCGWATSAPGNARF-----GQGSGPIVLDDVRCSGYESYLWSCPHNG 446

Query: 263 YRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKP------QGEARVRLKGGAHPG 316
           + +++   C     A V C     ++  S       + P      +    +RL  G    
Sbjct: 447 WLSHN---CQHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRC 503

Query: 317 EGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRC 376
           +GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   AR GQG G I L +VRC
Sbjct: 504 QGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSGPIVLDDVRC 563

Query: 377 SGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGG 436
           SG E  LW CPH    + +C HS+DAGV C+ P +    R+   G R Q  GRVEV   G
Sbjct: 564 SGNESYLWSCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQ--GRVEVLYRG 621

Query: 437 PGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTE 496
                WG +C D W T +A V CRQLG G+A        +        +V+  VRC+G E
Sbjct: 622 ----SWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSG--PIVLDDVRCSGHE 675

Query: 497 LSLDQCAHHGTHITCKRTGTRFTAGVICSETAS 529
             L  C ++G        G    AGVICS   S
Sbjct: 676 SYLWSCPNNGW--LSHNCGHHEDAGVICSAAQS 706



 Score =  262 bits (670), Expect = 8e-70
 Identities = 172/504 (34%), Positives = 240/504 (47%), Gaps = 47/504 (9%)

Query: 55   EGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSC 114
            +GRVE+   G WGT+CDD +    A+++CR+LG   AT    +A++G G+G I LD++ C
Sbjct: 612  QGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 671

Query: 115  SGTEQSVTECASRGWGNSDCTHDEDAGVIC---KDQRLPGFSDSNVIEVEHHLQVEE--V 169
            SG E  +  C + GW + +C H EDAGVIC   + +  P     + I +       E  +
Sbjct: 672  SGHESYLWSCPNNGWLSHNCGHHEDAGVICSAAQSRSTPRPDTLSTITLPPSTVGSESSL 731

Query: 170  RIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNA 227
             +R   G  R      +G VEV     W  VCD  W  ++++VVC  LG  + +    NA
Sbjct: 732  TLRLVNGSDR-----CQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNA 786

Query: 228  AFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVY 287
             F      +      L  V C G E++L  C    + +++       G         P  
Sbjct: 787  RF-----GQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSVSQSRPTP 841

Query: 288  AASSGQKKQQQSK-PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCR 346
            +  +       +  P+    +RL  G    +GRVEVL   +WGTVCD  WD   A+VVCR
Sbjct: 842  SPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTSDANVVCR 901

Query: 347  ELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC 406
            +LG G A  A   AR GQG G I L +VRCSG E  LW CPH    + +C HS+DAGV C
Sbjct: 902  QLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDAGVIC 961

Query: 407  NLPYT-------------------GAET--RIRLSGGRSQHEGRVEVQIGGPGPLRWGLI 445
            +  ++                   G+E+   +RL  G  + +GRVEV   G     WG +
Sbjct: 962  SAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYQG----SWGTV 1017

Query: 446  CGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHH 505
            C D W T +A V CRQLG G+A        +        +V+  VRC+G E  L  C H+
Sbjct: 1018 CDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSG--PIVLDDVRCSGHESYLWSCPHN 1075

Query: 506  GTHITCKRTGTRFTAGVICSETAS 529
            G        G    AGVICS + S
Sbjct: 1076 GW--LSHNCGHSEDAGVICSASQS 1097



 Score =  261 bits (666), Expect = 2e-69
 Identities = 181/544 (33%), Positives = 248/544 (45%), Gaps = 52/544 (9%)

Query: 18   LLCSSCLG--SPSPSTGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTIC 70
            ++CS+     +PSP T P   A + G    LA     G  R   +GRVE+   G WGT+C
Sbjct: 1090 VICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNGGDR--CQGRVEVLYRGSWGTVC 1147

Query: 71   DDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWG 130
            DD +    A+++CR+LG   A     +A++G G+G I LD++ CSG E  +  C   GW 
Sbjct: 1148 DDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWL 1207

Query: 131  NSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQV---EEVRIRPAVGWGRRPLPVTEG 187
            + +C H EDAGVIC   +       +     H         + +R   G  R      +G
Sbjct: 1208 SHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDR-----CQG 1262

Query: 188  LVEVRLPDGWSQVCDKGWSAHNSHVVCGML--GFPSEKRVNAAFYRLLAQRQQHSFGLHG 245
             VEV     W  VCD  W  ++++VVC  L  G+ +    NA F      +      L  
Sbjct: 1263 RVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARF-----GQGSGPIVLDD 1317

Query: 246  VACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK-PQGE 304
            V C G E++L  C    + +++       G    +    P  +  +       +   +  
Sbjct: 1318 VRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESS 1377

Query: 305  ARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQ 364
              +RL  G    +GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   AR GQ
Sbjct: 1378 LALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQ 1437

Query: 365  GMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNL------------PYTG 412
            G G I L +VRCSG E  LW CPH    + +C H +DAGV C+             P + 
Sbjct: 1438 GSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSR 1497

Query: 413  AET-------RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLG 465
            A T        +RL  G  +  GRVEV   G     WG +C D W T +A V CRQLG G
Sbjct: 1498 ASTAGSESTLALRLVNGGDRCRGRVEVLYQG----SWGTVCDDYWDTNDANVVCRQLGCG 1553

Query: 466  YANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICS 525
            +A        +        +V+  VRC+G E  L  C H+G        G    AGVICS
Sbjct: 1554 WAMSAPGNAQFGQGSG--PIVLDDVRCSGHESYLWSCPHNGW--LSHNCGHHEDAGVICS 1609

Query: 526  ETAS 529
               S
Sbjct: 1610 AAQS 1613



 Score =  259 bits (661), Expect = 8e-69
 Identities = 188/563 (33%), Positives = 256/563 (45%), Gaps = 53/563 (9%)

Query: 5   SVWQWSPWGLLLCLLCSSCLGS--PSPST--GPEKKAGSQGLRFRLAGFPRKPYEGRVEI 60
           +V + SP  L   L  +   GS  PS ST      +    GL  RL     +  +GRVEI
Sbjct: 59  TVAEGSPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGR-CQGRVEI 117

Query: 61  QRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQS 120
              G WGT+CDD +    A+++CR+LG   A     +A +G G+G I LD++ CSG E  
Sbjct: 118 LYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESY 177

Query: 121 VTECASRGWGNSDCTHDEDAGVICKDQRLPGF--SDSNVIEVEHHLQVE----EVRIRPA 174
           +  C   GW + +C H EDAGVIC   +       +S  + +   +  E     + +R  
Sbjct: 178 LWSCPHNGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLV 237

Query: 175 VGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGML--GFPSEKRVNAAFYRL 232
            G  R       G VEV     W  VCD  W  ++++VVC  L  G+      NA F   
Sbjct: 238 NGGDR-----CRGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQF--- 289

Query: 233 LAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSG 292
              +      L  V C G E++L  C    +  ++       G    +    P  +  + 
Sbjct: 290 --GQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNCGHSEDAGVICSAPQSRPTPSPDTW 347

Query: 293 QKKQQQSK-PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFG 351
                 +  P+    +RL  G    +GRVEVL   +WGTVCD  WD   A+VVCR+LG G
Sbjct: 348 PTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTSDANVVCRQLGCG 407

Query: 352 SAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYT 411
            A  A   AR GQG G I L +VRCSG E  LW CPH    + +C HS+DAGV C+  ++
Sbjct: 408 WATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDAGVICSAAHS 467

Query: 412 -------------------GAET--RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDW 450
                              G+E+   +RL  G  + +GRVEV   G     WG +C D W
Sbjct: 468 WSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYRG----SWGTVCDDSW 523

Query: 451 GTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHIT 510
            T +A V CRQLG G+A        +        +V+  VRC+G E  L  C H+G    
Sbjct: 524 DTNDANVVCRQLGCGWAMLAPGNARFGQGSG--PIVLDDVRCSGNESYLWSCPHNGW--L 579

Query: 511 CKRTGTRFTAGVICSETASDLLL 533
               G    AGVICS   S L L
Sbjct: 580 SHNCGHSEDAGVICSGPESSLAL 602



 Score =  211 bits (538), Expect = 2e-54
 Identities = 143/416 (34%), Positives = 193/416 (46%), Gaps = 33/416 (7%)

Query: 18   LLCSSCLGSPSPS--TGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTIC 70
            ++CS+    P+PS  T P   A + G    LA     G  R   +GRVE+   G WGT+C
Sbjct: 1348 VICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDR--CQGRVEVLYRGSWGTVC 1405

Query: 71   DDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWG 130
            DD +    A+++CR+LG   AT    +A++G G+G I LD++ CSG E  +  C   GW 
Sbjct: 1406 DDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWL 1465

Query: 131  NSDCTHDEDAGVIC---KDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEG 187
            + +C H EDAGVIC   + Q  P                  + +R   G  R       G
Sbjct: 1466 SHNCGHHEDAGVICSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDR-----CRG 1520

Query: 188  LVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGLHG 245
             VEV     W  VCD  W  ++++VVC  LG  +      NA F      +      L  
Sbjct: 1521 RVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQF-----GQGSGPIVLDD 1575

Query: 246  VACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKP---- 301
            V C G E++L  C    + +++   C     A V C      +          + P    
Sbjct: 1576 VRCSGHESYLWSCPHNGWLSHN---CGHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTV 1632

Query: 302  --QGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSG 359
              +    +RL  G     GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   
Sbjct: 1633 GSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGN 1692

Query: 360  ARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAET 415
            AR GQG G I L +VRCSG E  LW CPHK     +C H +DAGV C+     + T
Sbjct: 1693 ARFGQGSGPIVLDDVRCSGNESYLWSCPHKGWLTHNCGHHEDAGVICSATQINSTT 1748



 Score =  107 bits (266), Expect = 5e-23
 Identities = 46/94 (48%), Positives = 63/94 (67%)

Query: 56   GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
            GRVEI   G WGT+CDD +T+Q A ++CR+LG   A     +A +G G+G I LD++ CS
Sbjct: 1897 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECS 1956

Query: 116  GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRL 149
            GTE ++ +C +RGW + +C H EDAGVIC    L
Sbjct: 1957 GTESTLWQCRNRGWFSHNCNHREDAGVICSGNHL 1990



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 44/90 (48%), Positives = 57/90 (63%)

Query: 318  GRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCS 377
            GRVE+    TWGTVCD  W +  A VVCR+LG G A  AL  A  G G G I L +V CS
Sbjct: 1897 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECS 1956

Query: 378  GQELSLWKCPHKNITAEDCSHSQDAGVRCN 407
            G E +LW+C ++   + +C+H +DAGV C+
Sbjct: 1957 GTESTLWQCRNRGWFSHNCNHREDAGVICS 1986



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 41/98 (41%), Positives = 50/98 (51%), Gaps = 8/98 (8%)

Query: 428  GRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVM 487
            GRVE+  GG     WG +C D W   EA V CRQLG G A   L    Y+ SG+   + +
Sbjct: 1897 GRVEIYHGGT----WGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNA-YFGSGS-GPITL 1950

Query: 488  SGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICS 525
              V C+GTE +L QC + G          R  AGVICS
Sbjct: 1951 DDVECSGTESTLWQCRNRGWF--SHNCNHREDAGVICS 1986



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 23/72 (31%), Positives = 28/72 (38%), Gaps = 3/72 (4%)

Query: 187  GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGV 246
            G VE+     W  VCD  W+   + VVC  LG     R  +A              L  V
Sbjct: 1897 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGC---GRAVSALGNAYFGSGSGPITLDDV 1953

Query: 247  ACVGTEAHLSLC 258
             C GTE+ L  C
Sbjct: 1954 ECSGTESTLWQC 1965


>gi|148539840 deleted in malignant brain tumors 1 isoform a
           precursor [Homo sapiens]
          Length = 1785

 Score =  264 bits (675), Expect = 2e-70
 Identities = 180/536 (33%), Positives = 245/536 (45%), Gaps = 52/536 (9%)

Query: 26  SPSPSTGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAH 80
           +PSP T P   A + G    LA     G  R   +GRVE+   G WGT+CDD +    A+
Sbjct: 341 TPSPDTWPTSHASTAGPESSLALRLVNGGDR--CQGRVEVLYRGSWGTVCDDSWDTSDAN 398

Query: 81  ILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDA 140
           ++CR+LG   AT    +A++G G+G I LD++ CSG E  +  C   GW + +C H EDA
Sbjct: 399 VVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDA 458

Query: 141 GVICKDQRL-----PGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPD 195
           GVIC          P    +  +          + +R   G  R      +G VEV    
Sbjct: 459 GVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDR-----CQGRVEVLYQG 513

Query: 196 GWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEA 253
            W  VCD  W  ++++VVC  LG  +      NA F      +      L  V C G E+
Sbjct: 514 SWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARF-----GQGSGPIVLDDVRCSGHES 568

Query: 254 HLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK-PQGEARVRLKGG 312
           +L  C    + +++       G    +    P  +  +       +   +    +RL  G
Sbjct: 569 YLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNG 628

Query: 313 AHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLS 372
               +GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   AR GQG G I L 
Sbjct: 629 GDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLD 688

Query: 373 EVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNL------------PYTGAET----- 415
           +VRCSG E  LW CPH    + +C H +DAGV C+             P + A T     
Sbjct: 689 DVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSES 748

Query: 416 --RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQE 473
              +RL  G  + +GRVEV   G     WG +C D W T +A V CRQLG G+A      
Sbjct: 749 SLALRLVNGGDRCQGRVEVLYRG----SWGTVCDDYWDTNDANVVCRQLGCGWATSAPGN 804

Query: 474 TWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETAS 529
             +        +V+  VRC+G E  L  C H+G        G    AGVICS + S
Sbjct: 805 ARFGQGSG--PIVLDDVRCSGHESYLWSCPHNGW--LSHNCGHHEDAGVICSASQS 856



 Score =  262 bits (669), Expect = 1e-69
 Identities = 184/546 (33%), Positives = 251/546 (45%), Gaps = 58/546 (10%)

Query: 18   LLCSSCLG--SPSPSTGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTIC 70
            ++CS+     +PSP T P   A + G    LA     G  R   +GRVE+   G WGT+C
Sbjct: 591  VICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNGGDR--CQGRVEVLYRGSWGTVC 648

Query: 71   DDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWG 130
            DD +    A+++CR+LG   A     +A++G G+G I LD++ CSG E  +  C   GW 
Sbjct: 649  DDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWL 708

Query: 131  NSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQV---EEVRIRPAVGWGRRPLPVTEG 187
            + +C H EDAGVIC   +       +     H         + +R   G  R      +G
Sbjct: 709  SHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDR-----CQG 763

Query: 188  LVEVRLPDGWSQVCDKGWSAHNSHVVCGML--GFPSEKRVNAAFYRLLAQRQQHSFGLHG 245
             VEV     W  VCD  W  ++++VVC  L  G+ +    NA F      +      L  
Sbjct: 764  RVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARF-----GQGSGPIVLDD 818

Query: 246  VACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASS-GQKKQQQSKPQGE 304
            V C G E++L  C    + +++       G    +    P  +  +    +   +  +  
Sbjct: 819  VRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSRASTAGSEST 878

Query: 305  ARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQ 364
              +RL  G     GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   A+ GQ
Sbjct: 879  LALRLVNGGDRCRGRVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQFGQ 938

Query: 365  GMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC-----------------N 407
            G G I L +VRCSG E  LW CPH    + +C H +DAGV C                 N
Sbjct: 939  GSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSAAQSQSTPRPDTWLTTN 998

Query: 408  LP--YTGAET--RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLG 463
            LP    G+E+   +RL  G  +  GRVEV   G     WG +C D W T +A V CRQLG
Sbjct: 999  LPALTVGSESSLALRLVNGGDRCRGRVEVLYRG----SWGTVCDDSWDTNDANVVCRQLG 1054

Query: 464  LGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG--THITCKRTGTRFTAG 521
             G+A        +        +V+  VRC+G E  L  C H G  TH      G    AG
Sbjct: 1055 CGWAMSAPGNARFGQGSG--PIVLDDVRCSGNESYLWSCPHKGWLTH----NCGHHEDAG 1108

Query: 522  VICSET 527
            VICS T
Sbjct: 1109 VICSAT 1114



 Score =  257 bits (657), Expect = 2e-68
 Identities = 186/559 (33%), Positives = 255/559 (45%), Gaps = 53/559 (9%)

Query: 5   SVWQWSPWGLLLCLLCSSCLGS--PSPST--GPEKKAGSQGLRFRLAGFPRKPYEGRVEI 60
           +V + SP  L   L  +   GS  PS ST      +    GL  RL     +  +GRVEI
Sbjct: 59  TVAEGSPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGR-CQGRVEI 117

Query: 61  QRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQS 120
              G WGT+CDD +    A+++CR+LG   A     +A +G G+G I LD++ CSG E  
Sbjct: 118 LYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESY 177

Query: 121 VTECASRGWGNSDCTHDEDAGVICKDQRLPGF--SDSNVIEVEHHLQVE----EVRIRPA 174
           +  C   GW + +C H EDAGVIC   +       +S  + +   +  E     + +R  
Sbjct: 178 LWSCPHNGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLV 237

Query: 175 VGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRL 232
            G  R       G VEV     W  VCD  W  ++++VVC  LG  +      NA F   
Sbjct: 238 NGGDR-----CRGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQF--- 289

Query: 233 LAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSG 292
              +      L  V C G E++L  C    +  ++       G    +    P  +  + 
Sbjct: 290 --GQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNCGHSEDAGVICSAPQSRPTPSPDTW 347

Query: 293 QKKQQQSK-PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFG 351
                 +  P+    +RL  G    +GRVEVL   +WGTVCD  WD   A+VVCR+LG G
Sbjct: 348 PTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTSDANVVCRQLGCG 407

Query: 352 SAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYT 411
            A  A   AR GQG G I L +VRCSG E  LW CPH    + +C HS+DAGV C+  ++
Sbjct: 408 WATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDAGVICSAAHS 467

Query: 412 -------------------GAET--RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDW 450
                              G+E+   +RL  G  + +GRVEV   G     WG +C D W
Sbjct: 468 WSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYQG----SWGTVCDDSW 523

Query: 451 GTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHIT 510
            T +A V CRQLG G+A        +        +V+  VRC+G E  L  C H+G    
Sbjct: 524 DTNDANVVCRQLGCGWAMSAPGNARFGQGSG--PIVLDDVRCSGHESYLWSCPHNGW--L 579

Query: 511 CKRTGTRFTAGVICSETAS 529
               G    AGVICS + S
Sbjct: 580 SHNCGHSEDAGVICSASQS 598



 Score =  211 bits (538), Expect = 2e-54
 Identities = 143/416 (34%), Positives = 193/416 (46%), Gaps = 33/416 (7%)

Query: 18   LLCSSCLGSPSPS--TGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTIC 70
            ++CS+    P+PS  T P   A + G    LA     G  R   +GRVE+   G WGT+C
Sbjct: 720  VICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDR--CQGRVEVLYRGSWGTVC 777

Query: 71   DDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWG 130
            DD +    A+++CR+LG   AT    +A++G G+G I LD++ CSG E  +  C   GW 
Sbjct: 778  DDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWL 837

Query: 131  NSDCTHDEDAGVIC---KDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEG 187
            + +C H EDAGVIC   + Q  P                  + +R   G  R       G
Sbjct: 838  SHNCGHHEDAGVICSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDR-----CRG 892

Query: 188  LVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGLHG 245
             VEV     W  VCD  W  ++++VVC  LG  +      NA F      +      L  
Sbjct: 893  RVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQF-----GQGSGPIVLDD 947

Query: 246  VACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKP---- 301
            V C G E++L  C    + +++   C     A V C      +          + P    
Sbjct: 948  VRCSGHESYLWSCPHNGWLSHN---CGHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTV 1004

Query: 302  --QGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSG 359
              +    +RL  G     GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   
Sbjct: 1005 GSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGN 1064

Query: 360  ARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAET 415
            AR GQG G I L +VRCSG E  LW CPHK     +C H +DAGV C+     + T
Sbjct: 1065 ARFGQGSGPIVLDDVRCSGNESYLWSCPHKGWLTHNCGHHEDAGVICSATQINSTT 1120



 Score =  107 bits (266), Expect = 5e-23
 Identities = 46/94 (48%), Positives = 63/94 (67%)

Query: 56   GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
            GRVEI   G WGT+CDD +T+Q A ++CR+LG   A     +A +G G+G I LD++ CS
Sbjct: 1269 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECS 1328

Query: 116  GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRL 149
            GTE ++ +C +RGW + +C H EDAGVIC    L
Sbjct: 1329 GTESTLWQCRNRGWFSHNCNHREDAGVICSGNHL 1362



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 44/90 (48%), Positives = 57/90 (63%)

Query: 318  GRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCS 377
            GRVE+    TWGTVCD  W +  A VVCR+LG G A  AL  A  G G G I L +V CS
Sbjct: 1269 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECS 1328

Query: 378  GQELSLWKCPHKNITAEDCSHSQDAGVRCN 407
            G E +LW+C ++   + +C+H +DAGV C+
Sbjct: 1329 GTESTLWQCRNRGWFSHNCNHREDAGVICS 1358



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 41/98 (41%), Positives = 50/98 (51%), Gaps = 8/98 (8%)

Query: 428  GRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVM 487
            GRVE+  GG     WG +C D W   EA V CRQLG G A   L    Y+ SG+   + +
Sbjct: 1269 GRVEIYHGGT----WGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNA-YFGSGS-GPITL 1322

Query: 488  SGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICS 525
              V C+GTE +L QC + G          R  AGVICS
Sbjct: 1323 DDVECSGTESTLWQCRNRGWF--SHNCNHREDAGVICS 1358



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 23/72 (31%), Positives = 28/72 (38%), Gaps = 3/72 (4%)

Query: 187  GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGV 246
            G VE+     W  VCD  W+   + VVC  LG     R  +A              L  V
Sbjct: 1269 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGC---GRAVSALGNAYFGSGSGPITLDDV 1325

Query: 247  ACVGTEAHLSLC 258
             C GTE+ L  C
Sbjct: 1326 ECSGTESTLWQC 1337


>gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens]
          Length = 1788

 Score =  261 bits (667), Expect = 2e-69
 Identities = 193/556 (34%), Positives = 256/556 (46%), Gaps = 71/556 (12%)

Query: 18  LLCSSC--LGSPSPSTGPE-----KKAGSQG-LRFRLAGFPRKPYEGRVEIQRAGEWGTI 69
           ++CS+     +PSP T P         GS+  L  RL     +  +GRVE+   G WGT+
Sbjct: 460 VICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDR-CQGRVEVLYRGSWGTV 518

Query: 70  CDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGW 129
           CDD +    A+++CR+LG   A     +A++G G+G I LD++ CSG E  +  C   GW
Sbjct: 519 CDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSGPIVLDDVRCSGNESYLWSCPHNGW 578

Query: 130 GNSDCTHDEDAGVICKD-QRLPGFSDSNVIEVEHHLQV-----EEVRIRPAVGWGRRPLP 183
            + +C H EDAGVIC   Q LP           H LQ        + +R   G  R    
Sbjct: 579 LSHNCGHSEDAGVICSALQWLPTPIRPRSWPSSHALQTCKGPESSLALRLVNGGDR---- 634

Query: 184 VTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSF 241
             +G VEV     W  VCD  W  ++++VVC  LG  + +    NA F      +     
Sbjct: 635 -CQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARF-----GQGSGPI 688

Query: 242 GLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKP 301
            L  V C G E++L  C    + +++   C     A V C      AA S    +  + P
Sbjct: 689 VLDDVRCSGHESYLWSCPNNGWLSHN---CGHHEDAGVICS-----AAQSRSTPRPDTWP 740

Query: 302 QGEAR---------VRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGS 352
              A          +RL  G    +GRVEVL   +WGTVCD  WD + A+VVCR+LG G 
Sbjct: 741 TSHASTAGSESSLALRLVNGGDRCQGRVEVLYQGSWGTVCDDSWDTNDANVVCRQLGCGW 800

Query: 353 AREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNL---- 408
           A  A   AR GQG G I L +VRCSG E  LW CPH    + +C HS+DAGV C+     
Sbjct: 801 AMSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHSEDAGVICSASQSR 860

Query: 409 --------PYTGAET-------RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTL 453
                   P + A T        +RL  G  +  GRVEV   G     WG +C D W T 
Sbjct: 861 PTPSPDTWPTSRASTAGSESTLALRLVNGGDRCRGRVEVLYQG----SWGTVCDDYWDTN 916

Query: 454 EAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKR 513
           +A V CRQLG G+A        +        +V+  VRC+G E  L  C H+G       
Sbjct: 917 DANVVCRQLGCGWAMSAPGNAQFGQGSG--PIVLDDVRCSGHESYLWSCPHNGW--LSHN 972

Query: 514 TGTRFTAGVICSETAS 529
            G    AGVICS   S
Sbjct: 973 CGHHEDAGVICSAAQS 988



 Score =  260 bits (665), Expect = 3e-69
 Identities = 172/502 (34%), Positives = 234/502 (46%), Gaps = 49/502 (9%)

Query: 55   EGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSC 114
            +GRVE+   G WGT+CDD +    A+++CR+LG   AT    +A++G G+G I LD++ C
Sbjct: 636  QGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 695

Query: 115  SGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQV---EEVRI 171
            SG E  +  C + GW + +C H EDAGVIC   +       +     H         + +
Sbjct: 696  SGHESYLWSCPNNGWLSHNCGHHEDAGVICSAAQSRSTPRPDTWPTSHASTAGSESSLAL 755

Query: 172  RPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAF 229
            R   G  R      +G VEV     W  VCD  W  ++++VVC  LG  +      NA F
Sbjct: 756  RLVNGGDR-----CQGRVEVLYQGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARF 810

Query: 230  YRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAA 289
                  +      L  V C G E++L  C    + +++       G    +    P  + 
Sbjct: 811  -----GQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSP 865

Query: 290  SSGQKKQQQSK-PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCREL 348
             +    +  +   +    +RL  G     GRVEVL   +WGTVCD  WD + A+VVCR+L
Sbjct: 866  DTWPTSRASTAGSESTLALRLVNGGDRCRGRVEVLYQGSWGTVCDDYWDTNDANVVCRQL 925

Query: 349  GFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC-- 406
            G G A  A   A+ GQG G I L +VRCSG E  LW CPH    + +C H +DAGV C  
Sbjct: 926  GCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSA 985

Query: 407  ---------------NLPY--TGAETRI--RLSGGRSQHEGRVEVQIGGPGPLRWGLICG 447
                           NLP    G+E+ +  RL  G  +  GRVEV   G     WG +C 
Sbjct: 986  AQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRGRVEVLYRGS----WGTVCD 1041

Query: 448  DDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG- 506
            D W T +A V CRQLG G+A        +        +V+  VRC+G E  L  C H G 
Sbjct: 1042 DSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSG--PIVLDDVRCSGNESYLWSCPHKGW 1099

Query: 507  -THITCKRTGTRFTAGVICSET 527
             TH      G    AGVICS T
Sbjct: 1100 LTH----NCGHHEDAGVICSAT 1117



 Score =  253 bits (646), Expect = 5e-67
 Identities = 184/555 (33%), Positives = 252/555 (45%), Gaps = 53/555 (9%)

Query: 5   SVWQWSPWGLLLCLLCSSCLGS--PSPST--GPEKKAGSQGLRFRLAGFPRKPYEGRVEI 60
           +V + SP  L   L  +   GS  PS ST      +    GL  RL     +  +GRVEI
Sbjct: 59  TVAEGSPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGR-CQGRVEI 117

Query: 61  QRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQS 120
              G WGT+CDD +    A+++CR+LG   A     +A +G G+G I LD++ CSG E  
Sbjct: 118 LYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESY 177

Query: 121 VTECASRGWGNSDCTHDEDAGVICKDQRLPGF--SDSNVIEVEHHLQVE----EVRIRPA 174
           +  C   GW + +C H EDAGVIC   +       +S  + +   +  E     + +R  
Sbjct: 178 LWSCPHNGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLV 237

Query: 175 VGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRL 232
            G  R       G VEV     W  VCD  W  ++++VVC  LG  +      NA F   
Sbjct: 238 NGGDR-----CRGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQF--- 289

Query: 233 LAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSG 292
              +      L  V C G E++L  C    +  ++       G    +    P  +  + 
Sbjct: 290 --GQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNCGHSEDAGVICSAPQSRPTPSPDTW 347

Query: 293 QKKQQQSK-PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFG 351
                 +   +    +RL  G    +GRVEVL   +WGTVCD  WD   A+VVCR+LG G
Sbjct: 348 PTSHASTAGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTSDANVVCRQLGCG 407

Query: 352 SAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYT 411
            A  A   AR GQG G I L +VRCSG E  LW CPH    + +C HS+DAGV C+  ++
Sbjct: 408 WATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDAGVICSAAHS 467

Query: 412 -------------------GAET--RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDW 450
                              G+E+   +RL  G  + +GRVEV   G     WG +C D W
Sbjct: 468 WSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYRG----SWGTVCDDSW 523

Query: 451 GTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHIT 510
            T +A V CRQLG G+A        +        +V+  VRC+G E  L  C H+G    
Sbjct: 524 DTNDANVVCRQLGCGWAMLAPGNARFGQGSG--PIVLDDVRCSGNESYLWSCPHNGW--L 579

Query: 511 CKRTGTRFTAGVICS 525
               G    AGVICS
Sbjct: 580 SHNCGHSEDAGVICS 594



 Score =  208 bits (530), Expect = 1e-53
 Identities = 142/415 (34%), Positives = 190/415 (45%), Gaps = 31/415 (7%)

Query: 18   LLCSSCLG--SPSPSTGPEKKAGSQGLRFRLA-----GFPRKPYEGRVEIQRAGEWGTIC 70
            ++CS+     +P P T P   A + G    LA     G  R   +GRVE+   G WGT+C
Sbjct: 723  VICSAAQSRSTPRPDTWPTSHASTAGSESSLALRLVNGGDR--CQGRVEVLYQGSWGTVC 780

Query: 71   DDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWG 130
            DD +    A+++CR+LG   A     +A++G G+G I LD++ CSG E  +  C   GW 
Sbjct: 781  DDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWL 840

Query: 131  NSDCTHDEDAGVICK--DQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGL 188
            + +C H EDAGVIC     R     D+           E       V  G R      G 
Sbjct: 841  SHNCGHSEDAGVICSASQSRPTPSPDTWPTSRASTAGSESTLALRLVNGGDR----CRGR 896

Query: 189  VEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGLHGV 246
            VEV     W  VCD  W  ++++VVC  LG  +      NA F      +      L  V
Sbjct: 897  VEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQF-----GQGSGPIVLDDV 951

Query: 247  ACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKP----- 301
             C G E++L  C    + +++   C     A V C      +          + P     
Sbjct: 952  RCSGHESYLWSCPHNGWLSHN---CGHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVG 1008

Query: 302  -QGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGA 360
             +    +RL  G     GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   A
Sbjct: 1009 SESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNA 1068

Query: 361  RMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAET 415
            R GQG G I L +VRCSG E  LW CPHK     +C H +DAGV C+     + T
Sbjct: 1069 RFGQGSGPIVLDDVRCSGNESYLWSCPHKGWLTHNCGHHEDAGVICSATQINSTT 1123



 Score =  107 bits (266), Expect = 5e-23
 Identities = 46/94 (48%), Positives = 63/94 (67%)

Query: 56   GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
            GRVEI   G WGT+CDD +T+Q A ++CR+LG   A     +A +G G+G I LD++ CS
Sbjct: 1272 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECS 1331

Query: 116  GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRL 149
            GTE ++ +C +RGW + +C H EDAGVIC    L
Sbjct: 1332 GTESTLWQCRNRGWFSHNCNHREDAGVICSGNHL 1365



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 44/90 (48%), Positives = 57/90 (63%)

Query: 318  GRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCS 377
            GRVE+    TWGTVCD  W +  A VVCR+LG G A  AL  A  G G G I L +V CS
Sbjct: 1272 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECS 1331

Query: 378  GQELSLWKCPHKNITAEDCSHSQDAGVRCN 407
            G E +LW+C ++   + +C+H +DAGV C+
Sbjct: 1332 GTESTLWQCRNRGWFSHNCNHREDAGVICS 1361



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 41/98 (41%), Positives = 50/98 (51%), Gaps = 8/98 (8%)

Query: 428  GRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVM 487
            GRVE+  GG     WG +C D W   EA V CRQLG G A   L    Y+ SG+   + +
Sbjct: 1272 GRVEIYHGGT----WGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNA-YFGSGS-GPITL 1325

Query: 488  SGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICS 525
              V C+GTE +L QC + G          R  AGVICS
Sbjct: 1326 DDVECSGTESTLWQCRNRGWF--SHNCNHREDAGVICS 1361



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 23/72 (31%), Positives = 28/72 (38%), Gaps = 3/72 (4%)

Query: 187  GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGV 246
            G VE+     W  VCD  W+   + VVC  LG     R  +A              L  V
Sbjct: 1272 GRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGC---GRAVSALGNAYFGSGSGPITLDDV 1328

Query: 247  ACVGTEAHLSLC 258
             C GTE+ L  C
Sbjct: 1329 ECSGTESTLWQC 1340


>gi|20149540 lysyl oxidase preproprotein [Homo sapiens]
          Length = 417

 Score =  226 bits (576), Expect = 6e-59
 Identities = 106/202 (52%), Positives = 137/202 (67%), Gaps = 3/202 (1%)

Query: 530 DLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSARSANW-PYGHRRLLRFSSQIHNLG 588
           DL+     +Q + Y++   ++ L CAAEENCLAS+A  A+   Y HR LLRF  ++ N G
Sbjct: 214 DLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQG 273

Query: 589 RADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILTPNGTK-VAEGHKASFCLEDTECQED 647
            +DF P   R+SW WH CH HYHSMD F+HYD+L  N  + VAEGHKASFCLEDT C   
Sbjct: 274 TSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYG 333

Query: 648 VSKRYECANFGEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFT 707
             +R+ C     QG++ GC+D Y  DIDCQWIDITDVKPGNYIL+V +NP++ V ESD+T
Sbjct: 334 YHRRFACTAH-TQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYT 392

Query: 708 NNAMKCNCKYDGHRIWVHNCHI 729
           NN ++C+ +Y GH  +   C I
Sbjct: 393 NNVVRCDIRYTGHHAYASGCTI 414


>gi|50659091 scavenger receptor cysteine-rich type 1 precursor [Homo
           sapiens]
          Length = 1453

 Score =  226 bits (575), Expect = 8e-59
 Identities = 153/486 (31%), Positives = 222/486 (45%), Gaps = 62/486 (12%)

Query: 53  PYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNL 112
           P  G VE++  G+WGT+CDD +   A+ ++C++LG   +       +     G+IWLD++
Sbjct: 56  PCSGTVEVKFQGQWGTVCDDGWNTTASTVVCKQLGCPFSFAMFRFGQAVTRHGKIWLDDV 115

Query: 113 SCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIR 172
           SC G E ++ EC  R WG+ +C H ED GV C       + ++N+             +R
Sbjct: 116 SCYGNESALWECQHREWGSHNCYHGEDVGVNC-------YGEANL------------GLR 156

Query: 173 PAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRL 232
              G          G VEV+  + W  +CD GW+ + + VVC  LG PS    +      
Sbjct: 157 LVDGNNS-----CSGRVEVKFQERWGTICDDGWNLNTAAVVCRQLGCPSSFISSGVVNSP 211

Query: 233 LAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSG 292
              R      L  + C G E  L  C    +  +D   C       ++C     Y +S  
Sbjct: 212 AVLRP---IWLDDILCQGNELALWNCRHRGWGNHD---CSHNEDVTLTC-----YDSS-- 258

Query: 293 QKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGS 352
                      +  +RL GG +   GRVE+     WGTVC  KW+  AA VVC++LG G+
Sbjct: 259 -----------DLELRLVGGTNRCMGRVELKIQGRWGTVCHHKWNNAAADVVCKQLGCGT 307

Query: 353 AREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTG 412
           A        +  G   + L  V CSG E  LW C H      DC H  D  V C+    G
Sbjct: 308 ALHFAGLPHLQSGSDVVWLDGVSCSGNESFLWDCRHSGTVNFDCLHQNDVSVICS---DG 364

Query: 413 AETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQ 472
           A+  +RL+ G +   GRVEV+I      +W  IC  +W   +A+V C+QLG  ++  G +
Sbjct: 365 ADLELRLADGSNNCSGRVEVRIHE----QWWTICDQNWKNEQALVVCKQLGCPFSVFGSR 420

Query: 473 ETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG-THITCKRTGTRFTAGVICSETAS-D 530
                 S    ++ ++ + CTG E +L  C + G    TC R   R  AGVICS+ A  D
Sbjct: 421 RA--KPSNEARDIWINSISCTGNESALWDCTYDGKAKRTCFR---RSDAGVICSDKADLD 475

Query: 531 LLLHSA 536
           L L  A
Sbjct: 476 LRLVGA 481



 Score =  206 bits (523), Expect = 8e-53
 Identities = 128/352 (36%), Positives = 170/352 (48%), Gaps = 52/352 (14%)

Query: 56   GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
            GRVEI   G WGTICDD + L  AH++C++LG   A   T SA +G G+G IWLD+L+C+
Sbjct: 1047 GRVEIYHDGFWGTICDDGWDLSDAHVVCQKLGCGVAFNATVSAHFGEGSGPIWLDDLNCT 1106

Query: 116  GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAV 175
            G E  + +C SRGWG  DC H EDAGVIC        S+   + +    + E        
Sbjct: 1107 GMESHLWQCPSRGWGQHDCRHKEDAGVIC--------SEFTALRLYSETETESCA----- 1153

Query: 176  GWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQ 235
                       G +EV     W  V  +  +   + +VC  LG                 
Sbjct: 1154 -----------GRLEVFYNGTWGSVGRRNITTAIAGIVCRQLGC---------------- 1186

Query: 236  RQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKK 295
                  G +GV  +   A LS     F   +D  +CP    ++  C+  P     S    
Sbjct: 1187 ------GENGVVSL---APLSKTGSGFMWVDDI-QCPKTHISIWQCLSAPWERRISSPA- 1235

Query: 296  QQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSARE 355
             +++    E R+R++GG     GRVE+  A +WGTVCD  WDL  A VVC++LG GSA  
Sbjct: 1236 -EETWITCEDRIRVRGGDTECSGRVEIWHAGSWGTVCDDSWDLAEAEVVCQQLGCGSALA 1294

Query: 356  ALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCN 407
            AL  A  GQG G I L ++RC G E  LW C  K     DC H +DAGVRC+
Sbjct: 1295 ALRDASFGQGTGTIWLDDMRCKGNESFLWDCHAKPWGQSDCGHKEDAGVRCS 1346



 Score =  205 bits (522), Expect = 1e-52
 Identities = 150/508 (29%), Positives = 214/508 (42%), Gaps = 73/508 (14%)

Query: 56   GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
            GR+E+   G WGT+CDD +  +AA ++C +L    +           G G+IWLD++SC 
Sbjct: 594  GRLEVYFQGRWGTVCDDGWNSKAAAVVCSQLDCPSSIIGMGLGNASTGYGKIWLDDVSCD 653

Query: 116  GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAV 175
            G E  +  C + GWGN+DC+H ED GVIC D                     ++ +R   
Sbjct: 654  GDESDLWSCRNSGWGNNDCSHSEDVGVICSD-------------------ASDMELRLVG 694

Query: 176  GWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQ 235
            G  R       G VEV +      +C  GW  + + VVC  L   S  RV+         
Sbjct: 695  GSSR-----CAGKVEVNVQGAVGILCANGWGMNIAEVVCRQLECGSAIRVSR-------- 741

Query: 236  RQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKK 295
                            E H +  +L    +N  + C GG  ++  C+       +     
Sbjct: 742  ----------------EPHFTERTLHILMSN--SGCTGGEASLWDCIRWEWKQTACHLNM 783

Query: 296  QQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSARE 355
            +         + RL G   P  GRVEV  A TW +VCD  + LHAA+V+CREL  G A  
Sbjct: 784  EASLICSAHRQPRLVGADMPCSGRVEVKHADTWRSVCDSDFSLHAANVLCRELNCGDAIS 843

Query: 356  ALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAET 415
               G   G+G G     + +C G E  L  CP      + C HS++ GV C+       T
Sbjct: 844  LSVGDHFGKGNGLTWAEKFQCEGSETHLALCPIVQHPEDTCIHSREVGVVCS-----RYT 898

Query: 416  RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETW 475
             +RL  G+SQ +G+VE+ + G     WG +C   W   +A V CRQL  G A       +
Sbjct: 899  DVRLVNGKSQCDGQVEINVLG----HWGSLCDTHWDPEDARVLCRQLSCGTALSTTGGKY 954

Query: 476  YWDSGNITEVVMSGVRCTGTELSLDQC---------AHHGTHITCKRTGTRFTAGVICSE 526
              +      V      C G E  LD C           HG  ++   TG+       C  
Sbjct: 955  IGERS--VRVWGHRFHCLGNESLLDNCQMTVLGAPPCIHGNTVSVICTGSLTQPLFPCLA 1012

Query: 527  TASDLLLHSALVQETAYI--EDRPLHML 552
              SD  L SA+ + +A I  ED+ L ++
Sbjct: 1013 NVSDPYL-SAVPEGSALICLEDKRLRLV 1039



 Score =  204 bits (520), Expect = 2e-52
 Identities = 149/505 (29%), Positives = 208/505 (41%), Gaps = 81/505 (16%)

Query: 39  SQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSA 98
           S  L  RL G   +   GRVE++  G WGT+C   +   AA ++C++LG   A  +    
Sbjct: 257 SSDLELRLVGGTNRCM-GRVELKIQGRWGTVCHHKWNNAAADVVCKQLGCGTALHFAGLP 315

Query: 99  KYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVI 158
               G+  +WLD +SCSG E  + +C   G  N DC H  D  VIC D            
Sbjct: 316 HLQSGSDVVWLDGVSCSGNESFLWDCRHSGTVNFDCLHQNDVSVICSDG----------- 364

Query: 159 EVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG 218
                    ++ +R A G          G VEVR+ + W  +CD+ W    + VVC  LG
Sbjct: 365 --------ADLELRLADGSNN-----CSGRVEVRIHEQWWTICDQNWKNEQALVVCKQLG 411

Query: 219 FPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAV 278
            P          R     +     ++ ++C G E+ L  C+   Y       C     A 
Sbjct: 412 CPFSV---FGSRRAKPSNEARDIWINSISCTGNESALWDCT---YDGKAKRTCFRRSDAG 465

Query: 279 VSCVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDL 338
           V C                    + +  +RL G   P  GR+EV     WGTVC  +W  
Sbjct: 466 VIC------------------SDKADLDLRLVGAHSPCYGRLEVKYQGEWGTVCHDRWST 507

Query: 339 HAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSH 398
             A+VVC++LG G            +  G I L +V C G E ++W C H      +C H
Sbjct: 508 RNAAVVCKQLGCGKPMHVFGMTYFKEASGPIWLDDVSCIGNESNIWDCEHSGWGKHNCVH 567

Query: 399 SQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVA 458
            +D  V C+     A   +RL GG ++  GR+EV   G    RWG +C D W +  A V 
Sbjct: 568 REDVIVTCS---GDATWGLRLVGGSNRCSGRLEVYFQG----RWGTVCDDGWNSKAAAVV 620

Query: 459 CRQL---------GLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG-TH 508
           C QL         GLG A+ G  + W           +  V C G E  L  C + G  +
Sbjct: 621 CSQLDCPSSIIGMGLGNASTGYGKIW-----------LDDVSCDGDESDLWSCRNSGWGN 669

Query: 509 ITCKRTGTRFTAGVICSETASDLLL 533
             C  +      GVICS+ ASD+ L
Sbjct: 670 NDCSHSE---DVGVICSD-ASDMEL 690



 Score =  195 bits (495), Expect = 1e-49
 Identities = 141/462 (30%), Positives = 200/462 (43%), Gaps = 79/462 (17%)

Query: 56  GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEA---TGWTHSAKYGPGTGR-IWLDN 111
           GRVE++    WGTICDD + L  A ++CR+LG   +   +G  +S    P   R IWLD+
Sbjct: 166 GRVEVKFQERWGTICDDGWNLNTAAVVCRQLGCPSSFISSGVVNS----PAVLRPIWLDD 221

Query: 112 LSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRI 171
           + C G E ++  C  RGWGN DC+H+ED  + C D                     ++ +
Sbjct: 222 ILCQGNELALWNCRHRGWGNHDCSHNEDVTLTCYDS-------------------SDLEL 262

Query: 172 RPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYR 231
           R   G  R       G VE+++   W  VC   W+   + VVC  LG  +     A  + 
Sbjct: 263 RLVGGTNR-----CMGRVELKIQGRWGTVCHHKWNNAAADVVCKQLGCGT-----ALHFA 312

Query: 232 LLAQRQQHS--FGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAA 289
            L   Q  S    L GV+C G E+ L  C    +       C       V C  G     
Sbjct: 313 GLPHLQSGSDVVWLDGVSCSGNESFLWDCR---HSGTVNFDCLHQNDVSVICSDG----- 364

Query: 290 SSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELG 349
                         +  +RL  G++   GRVEV     W T+CD+ W    A VVC++LG
Sbjct: 365 -------------ADLELRLADGSNNCSGRVEVRIHEQWWTICDQNWKNEQALVVCKQLG 411

Query: 350 -----FGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGV 404
                FGS R     A+       I ++ + C+G E +LW C +       C    DAGV
Sbjct: 412 CPFSVFGSRR-----AKPSNEARDIWINSISCTGNESALWDCTYDGKAKRTCFRRSDAGV 466

Query: 405 RCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGL 464
            C+     A+  +RL G  S   GR+EV+  G     WG +C D W T  A V C+QLG 
Sbjct: 467 ICS---DKADLDLRLVGAHSPCYGRLEVKYQG----EWGTVCHDRWSTRNAAVVCKQLGC 519

Query: 465 GYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG 506
           G   H    T++ ++     + +  V C G E ++  C H G
Sbjct: 520 GKPMHVFGMTYFKEASG--PIWLDDVSCIGNESNIWDCEHSG 559



 Score =  194 bits (494), Expect = 2e-49
 Identities = 133/447 (29%), Positives = 199/447 (44%), Gaps = 57/447 (12%)

Query: 56  GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
           GRVE++   +W TICD ++  + A ++C++LG   +   +  AK       IW++++SC+
Sbjct: 380 GRVEVRIHEQWWTICDQNWKNEQALVVCKQLGCPFSVFGSRRAKPSNEARDIWINSISCT 439

Query: 116 GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAV 175
           G E ++ +C   G     C    DAGVIC D+     +D ++  V  H            
Sbjct: 440 GNESALWDCTYDGKAKRTCFRRSDAGVICSDK-----ADLDLRLVGAHSPCY-------- 486

Query: 176 GWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQ 235
                      G +EV+    W  VC   WS  N+ VVC  LG      V    Y    +
Sbjct: 487 -----------GRLEVKYQGEWGTVCHDRWSTRNAAVVCKQLGCGKPMHVFGMTY---FK 532

Query: 236 RQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKK 295
                  L  V+C+G E+++  C    +  ++   C      +V+C     +        
Sbjct: 533 EASGPIWLDDVSCIGNESNIWDCEHSGWGKHN---CVHREDVIVTCSGDATWG------- 582

Query: 296 QQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSARE 355
                      +RL GG++   GR+EV     WGTVCD  W+  AA+VVC +L   S+  
Sbjct: 583 -----------LRLVGGSNRCSGRLEVYFQGRWGTVCDDGWNSKAAAVVCSQLDCPSSII 631

Query: 356 ALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAET 415
            +       G G I L +V C G E  LW C +      DCSHS+D GV C+     ++ 
Sbjct: 632 GMGLGNASTGYGKIWLDDVSCDGDESDLWSCRNSGWGNNDCSHSEDVGVICS---DASDM 688

Query: 416 RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETW 475
            +RL GG S+  G+VEV + G      G++C + WG   A V CRQL  G A    +E  
Sbjct: 689 ELRLVGGSSRCAGKVEVNVQG----AVGILCANGWGMNIAEVVCRQLECGSAIRVSREPH 744

Query: 476 YWDSGNITEVVMSGVRCTGTELSLDQC 502
           + +      ++MS   CTG E SL  C
Sbjct: 745 FTE--RTLHILMSNSGCTGGEASLWDC 769



 Score =  192 bits (488), Expect = 1e-48
 Identities = 133/463 (28%), Positives = 198/463 (42%), Gaps = 56/463 (12%)

Query: 53   PYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNL 112
            P  GRVE++ A  W ++CD DF+L AA++LCREL   +A   +    +G G G  W +  
Sbjct: 803  PCSGRVEVKHADTWRSVCDSDFSLHAANVLCRELNCGDAISLSVGDHFGKGNGLTWAEKF 862

Query: 113  SCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIR 172
             C G+E  +  C         C H  + GV+C       ++D  ++  +           
Sbjct: 863  QCEGSETHLALCPIVQHPEDTCIHSREVGVVCS-----RYTDVRLVNGKSQ--------- 908

Query: 173  PAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRL 232
                         +G VE+ +   W  +CD  W   ++ V+C  L   +        Y  
Sbjct: 909  ------------CDGQVEINVLGHWGSLCDTHWDPEDARVLCRQLSCGTALSTTGGKY-- 954

Query: 233  LAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSC---VPGPVYAA 289
            + +R    +G H   C+G E+ L  C +    A     C  G    V C   +  P++  
Sbjct: 955  IGERSVRVWG-HRFHCLGNESLLDNCQMTVLGA---PPCIHGNTVSVICTGSLTQPLFPC 1010

Query: 290  SSGQKKQQQSK-PQGEA-------RVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAA 341
             +       S  P+G A       R+RL  G     GRVE+     WGT+CD  WDL  A
Sbjct: 1011 LANVSDPYLSAVPEGSALICLEDKRLRLVDGDSRCAGRVEIYHDGFWGTICDDGWDLSDA 1070

Query: 342  SVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQD 401
             VVC++LG G A  A   A  G+G G I L ++ C+G E  LW+CP +     DC H +D
Sbjct: 1071 HVVCQKLGCGVAFNATVSAHFGEGSGPIWLDDLNCTGMESHLWQCPSRGWGQHDCRHKED 1130

Query: 402  AGVRCNLPYTGAETRIRLSGGRSQHE--GRVEVQIGGPGPLRWGLICGDDWGTLEAMVAC 459
            AGV C+       T +RL          GR+EV   G     WG +   +  T  A + C
Sbjct: 1131 AGVICS-----EFTALRLYSETETESCAGRLEVFYNG----TWGSVGRRNITTAIAGIVC 1181

Query: 460  RQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQC 502
            RQLG G   +G+             + +  ++C  T +S+ QC
Sbjct: 1182 RQLGCG--ENGVVSLAPLSKTGSGFMWVDDIQCPKTHISIWQC 1222



 Score =  160 bits (406), Expect = 3e-39
 Identities = 135/484 (27%), Positives = 193/484 (39%), Gaps = 60/484 (12%)

Query: 55   EGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSC 114
            +G+VEI   G WG++CD  +  + A +LCR+L    A   T     G  + R+W     C
Sbjct: 910  DGQVEINVLGHWGSLCDTHWDPEDARVLCRQLSCGTALSTTGGKYIGERSVRVWGHRFHC 969

Query: 115  SGTEQSVTECASRGWGNSDCTHDEDAGVICKDQR-------LPGFSD---SNVIEVEHHL 164
             G E  +  C     G   C H     VIC           L   SD   S V E    +
Sbjct: 970  LGNESLLDNCQMTVLGAPPCIHGNTVSVICTGSLTQPLFPCLANVSDPYLSAVPEGSALI 1029

Query: 165  QVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKR 224
             +E+ R+R   G  R       G VE+     W  +CD GW   ++HVVC  LG      
Sbjct: 1030 CLEDKRLRLVDGDSR-----CAGRVEIYHDGFWGTICDDGWDLSDAHVVCQKLG------ 1078

Query: 225  VNAAFYRLLAQRQQHSFG---LHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSC 281
               AF   ++       G   L  + C G E+HL  C    +  +D   C     A V C
Sbjct: 1079 CGVAFNATVSAHFGEGSGPIWLDDLNCTGMESHLWQCPSRGWGQHD---CRHKEDAGVIC 1135

Query: 282  VPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAA 341
                    S     +  S+ + E+            GR+EV    TWG+V  R      A
Sbjct: 1136 --------SEFTALRLYSETETESCA----------GRLEVFYNGTWGSVGRRNITTAIA 1177

Query: 342  SVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQD 401
             +VCR+LG G             G G + + +++C    +S+W+C          S +++
Sbjct: 1178 GIVCRQLGCGENGVVSLAPLSKTGSGFMWVDDIQCPKTHISIWQCLSAPWERRISSPAEE 1237

Query: 402  AGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQ 461
              + C       E RIR+ GG ++  GRVE+   G     WG +C D W   EA V C+Q
Sbjct: 1238 TWITC-------EDRIRVRGGDTECSGRVEIWHAGS----WGTVCDDSWDLAEAEVVCQQ 1286

Query: 462  LGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAG 521
            LG G A   L++  +        + +  +RC G E  L  C  H         G +  AG
Sbjct: 1287 LGCGSALAALRDASFGQGTG--TIWLDDMRCKGNESFLWDC--HAKPWGQSDCGHKEDAG 1342

Query: 522  VICS 525
            V CS
Sbjct: 1343 VRCS 1346



 Score =  155 bits (392), Expect = 1e-37
 Identities = 121/429 (28%), Positives = 171/429 (39%), Gaps = 64/429 (14%)

Query: 42  LRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYG 101
           L  RL G    P  GR+E++  GEWGT+C D ++ + A ++C++LG  +         + 
Sbjct: 474 LDLRLVG-AHSPCYGRLEVKYQGEWGTVCHDRWSTRNAAVVCKQLGCGKPMHVFGMTYFK 532

Query: 102 PGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVE 161
             +G IWLD++SC G E ++ +C   GWG  +C H ED  V C      G          
Sbjct: 533 EASGPIWLDDVSCIGNESNIWDCEHSGWGKHNCVHREDVIVTCSGDATWGLR-------- 584

Query: 162 HHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPS 221
                        VG   R      G +EV     W  VCD GW++  + VVC  L  PS
Sbjct: 585 ------------LVGGSNR----CSGRLEVYFQGRWGTVCDDGWNSKAAAVVCSQLDCPS 628

Query: 222 EKRVNAAFYRLLAQRQQHSFG---LHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAV 278
                 +   +        +G   L  V+C G E+ L  C    +  ND   C       
Sbjct: 629 ------SIIGMGLGNASTGYGKIWLDDVSCDGDESDLWSCRNSGWGNND---CSHSEDVG 679

Query: 279 VSCVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDL 338
           V C                      +  +RL GG+    G+VEV      G +C   W +
Sbjct: 680 VIC------------------SDASDMELRLVGGSSRCAGKVEVNVQGAVGILCANGWGM 721

Query: 339 HAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSH 398
           + A VVCR+L  GSA          +    I +S   C+G E SLW C         C  
Sbjct: 722 NIAEVVCRQLECGSAIRVSREPHFTERTLHILMSNSGCTGGEASLWDCIRWEWKQTACHL 781

Query: 399 SQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVA 458
           + +A + C+     A  + RL G      GRVEV+        W  +C  D+    A V 
Sbjct: 782 NMEASLICS-----AHRQPRLVGADMPCSGRVEVKHAD----TWRSVCDSDFSLHAANVL 832

Query: 459 CRQLGLGYA 467
           CR+L  G A
Sbjct: 833 CRELNCGDA 841



 Score =  145 bits (367), Expect = 1e-34
 Identities = 130/500 (26%), Positives = 189/500 (37%), Gaps = 92/500 (18%)

Query: 56   GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
            G+VE+   G  G +C + + +  A ++CR+L    A   +    +   T  I + N  C+
Sbjct: 701  GKVEVNVQGAVGILCANGWGMNIAEVVCRQLECGSAIRVSREPHFTERTLHILMSNSGCT 760

Query: 116  GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAV 175
            G E S+ +C    W  + C  + +A +IC   R P    +++                  
Sbjct: 761  GGEASLWDCIRWEWKQTACHLNMEASLICSAHRQPRLVGADM------------------ 802

Query: 176  GWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGML--GFPSEKRVNAAFYRLL 233
                       G VEV+  D W  VCD  +S H ++V+C  L  G      V   F +  
Sbjct: 803  --------PCSGRVEVKHADTWRSVCDSDFSLHAANVLCRELNCGDAISLSVGDHFGKGN 854

Query: 234  AQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQ 293
                   F      C G+E HL+LC +      DT  C       V C            
Sbjct: 855  GLTWAEKF-----QCEGSETHLALCPI-VQHPEDT--CIHSREVGVVC------------ 894

Query: 294  KKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSA 353
                         VRL  G    +G+VE+     WG++CD  WD   A V+CR+L  G+A
Sbjct: 895  --------SRYTDVRLVNGKSQCDGQVEINVLGHWGSLCDTHWDPEDARVLCRQLSCGTA 946

Query: 354  REALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC------- 406
                 G  +G+    +      C G E  L  C    + A  C H     V C       
Sbjct: 947  LSTTGGKYIGERSVRVWGHRFHCLGNESLLDNCQMTVLGAPPCIHGNTVSVICTGSLTQP 1006

Query: 407  --------NLPYTGA-----------ETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICG 447
                    + PY  A           + R+RL  G S+  GRVE+   G     WG IC 
Sbjct: 1007 LFPCLANVSDPYLSAVPEGSALICLEDKRLRLVDGDSRCAGRVEIYHDG----FWGTICD 1062

Query: 448  DDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG- 506
            D W   +A V C++LG G A +      + +      + +  + CTG E  L QC   G 
Sbjct: 1063 DGWDLSDAHVVCQKLGCGVAFNATVSAHFGEGSG--PIWLDDLNCTGMESHLWQCPSRGW 1120

Query: 507  THITCKRTGTRFTAGVICSE 526
                C+    +  AGVICSE
Sbjct: 1121 GQHDCRH---KEDAGVICSE 1137



 Score =  122 bits (307), Expect = 9e-28
 Identities = 74/208 (35%), Positives = 103/208 (49%), Gaps = 19/208 (9%)

Query: 304 EARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMG 363
           +  +RL  G  P  G VEV     WGTVCD  W+  A++VVC++LG      + +  R G
Sbjct: 45  DLELRLVNGDGPCSGTVEVKFQGQWGTVCDDGWNTTASTVVCKQLG---CPFSFAMFRFG 101

Query: 364 QGM---GAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLS 420
           Q +   G I L +V C G E +LW+C H+   + +C H +D GV C   Y  A   +RL 
Sbjct: 102 QAVTRHGKIWLDDVSCYGNESALWECQHREWGSHNCYHGEDVGVNC---YGEANLGLRLV 158

Query: 421 GGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGL--GYANHGLQETWYWD 478
            G +   GRVEV+       RWG IC D W    A V CRQLG    + + G+  +    
Sbjct: 159 DGNNSCSGRVEVKF----QERWGTICDDGWNLNTAAVVCRQLGCPSSFISSGVVNS---- 210

Query: 479 SGNITEVVMSGVRCTGTELSLDQCAHHG 506
              +  + +  + C G EL+L  C H G
Sbjct: 211 PAVLRPIWLDDILCQGNELALWNCRHRG 238



 Score =  108 bits (269), Expect = 2e-23
 Identities = 47/101 (46%), Positives = 62/101 (61%)

Query: 56   GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
            GRVEI  AG WGT+CDD + L  A ++C++LG   A      A +G GTG IWLD++ C 
Sbjct: 1257 GRVEIWHAGSWGTVCDDSWDLAEAEVVCQQLGCGSALAALRDASFGQGTGTIWLDDMRCK 1316

Query: 116  GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSN 156
            G E  + +C ++ WG SDC H EDAGV C  Q L   + S+
Sbjct: 1317 GNESFLWDCHAKPWGQSDCGHKEDAGVRCSGQSLKSLNASS 1357



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 16/105 (15%)

Query: 410 YTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYA-- 467
           + G +  +RL  G     G VEV+  G    +WG +C D W T  + V C+QLG  ++  
Sbjct: 41  FNGTDLELRLVNGDGPCSGTVEVKFQG----QWGTVCDDGWNTTASTVVCKQLGCPFSFA 96

Query: 468 --NHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHH--GTH 508
               G   T +       ++ +  V C G E +L +C H   G+H
Sbjct: 97  MFRFGQAVTRH------GKIWLDDVSCYGNESALWECQHREWGSH 135


>gi|18152779 scavenger receptor cysteine rich domain containing,
           group B (4 domains) [Homo sapiens]
          Length = 575

 Score =  224 bits (570), Expect = 3e-58
 Identities = 165/513 (32%), Positives = 224/513 (43%), Gaps = 70/513 (13%)

Query: 45  RLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGT 104
           RL G P +   GR+E+   G WG++CDDD+ +  A+++CR+LG   A        +G G 
Sbjct: 59  RLVGGPSR-CRGRLEVMHGGSWGSVCDDDWDVVDANVVCRQLGCGLALPVPRPLAFGQGR 117

Query: 105 GRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHL 164
           G I LDN+ C G E +++EC SRGWG  +C H ED  V+C D+ LP    +  +      
Sbjct: 118 GPILLDNVECRGQEAALSECGSRGWGVHNCFHYEDVAVLC-DEFLPTQPPTRKMLTSRAP 176

Query: 165 QV------EEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG 218
                    E  +R   G       + +G VE+     W  VCD  W   ++ VVC  LG
Sbjct: 177 PTTLPNGKSEGSVRLVGGAN-----LCQGRVEILHSGLWGTVCDDDWGLPDAAVVCRQLG 231

Query: 219 FPSEKRVNA-AFYRLLAQRQQHSFGLHGVACVGTEAHLSLC-SLEF------YRANDTAR 270
             +       AF+        H   L  V C G E  L+ C SL +      +  +  A 
Sbjct: 232 CGAAMAATTNAFF---GYGTGHIL-LDNVHCEGGEPRLAACQSLGWGVHNCGHHEDAGAL 287

Query: 271 CPGGGPAVVSCVPGPVY-----------AASSGQKKQQQSK---------PQGEARVRLK 310
           C G GP  ++ +P               A   G +  +++           +   R+RL 
Sbjct: 288 CAGLGPPTLTALPSSATREDWAWQTDPSATGVGPQPSRETALLTTAAWAAGKKSGRLRLV 347

Query: 311 GGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIH 370
           GG  P  GRVEVL A  WGTVCD  WD   A V CRE G G A  A      G G G + 
Sbjct: 348 GGPGPCRGRVEVLHAGGWGTVCDDDWDFADARVACREAGCGPALGATGLGHFGYGRGPVL 407

Query: 371 LSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLP--------YTGAET------- 415
           L  V C+G E  L  C H      +C H +DAG  C  P          G+ET       
Sbjct: 408 LDNVGCAGTEARLSDCFHLGWGQHNCGHHEDAGALCAGPEELGLQVQQDGSETTRVPTPR 467

Query: 416 ----RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGL 471
                +RL  G  + EGRVE+ +G     RWG +C D W    A V CRQLG G A    
Sbjct: 468 PRDGHLRLVNGAHRCEGRVELYLG----QRWGTVCDDAWDLRAAGVLCRQLGCGQALAAP 523

Query: 472 QETWYWDSGNITEVVMSGVRCTGTELSLDQCAH 504
            E  +        +++  V+C G E +L  C+H
Sbjct: 524 GEAHFGPGRG--PILLDNVKCRGEESALLLCSH 554



 Score =  198 bits (503), Expect = 2e-50
 Identities = 137/388 (35%), Positives = 172/388 (44%), Gaps = 50/388 (12%)

Query: 55  EGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSC 114
           +GRVEI  +G WGT+CDDD+ L  A ++CR+LG   A   T +A +G GTG I LDN+ C
Sbjct: 199 QGRVEILHSGLWGTVCDDDWGLPDAAVVCRQLGCGAAMAATTNAFFGYGTGHILLDNVHC 258

Query: 115 SGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFS--DSNVIEVEHHLQVE----- 167
            G E  +  C S GWG  +C H EDAG +C     P  +   S+    +   Q +     
Sbjct: 259 EGGEPRLAACQSLGWGVHNCGHHEDAGALCAGLGPPTLTALPSSATREDWAWQTDPSATG 318

Query: 168 -------EVRIRPAVGW------GRRPLP----VTEGLVEVRLPDGWSQVCDKGWSAHNS 210
                  E  +     W      GR  L        G VEV    GW  VCD  W   ++
Sbjct: 319 VGPQPSRETALLTTAAWAAGKKSGRLRLVGGPGPCRGRVEVLHAGGWGTVCDDDWDFADA 378

Query: 211 HVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFG-------LHGVACVGTEAHLSLCSLEFY 263
            V C   G              L       FG       L  V C GTEA LS C   F+
Sbjct: 379 RVACREAGCGPA----------LGATGLGHFGYGRGPVLLDNVGCAGTEARLSDC---FH 425

Query: 264 RANDTARCPGGGPAVVSCVPGP----VYAASSGQKKQQQSKPQG-EARVRLKGGAHPGEG 318
                  C     A   C  GP    +     G +  +   P+  +  +RL  GAH  EG
Sbjct: 426 LGWGQHNCGHHEDAGALCA-GPEELGLQVQQDGSETTRVPTPRPRDGHLRLVNGAHRCEG 484

Query: 319 RVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSG 378
           RVE+     WGTVCD  WDL AA V+CR+LG G A  A   A  G G G I L  V+C G
Sbjct: 485 RVELYLGQRWGTVCDDAWDLRAAGVLCRQLGCGQALAAPGEAHFGPGRGPILLDNVKCRG 544

Query: 379 QELSLWKCPHKNITAEDCSHSQDAGVRC 406
           +E +L  C H    A +C HS+DA V C
Sbjct: 545 EESALLLCSHIRWDAHNCDHSEDASVLC 572



 Score =  143 bits (361), Expect = 5e-34
 Identities = 121/387 (31%), Positives = 156/387 (40%), Gaps = 59/387 (15%)

Query: 187 GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHS-FGLHG 245
           G +EV     W  VCD  W   +++VVC  LG      V     R LA  Q      L  
Sbjct: 69  GRLEVMHGGSWGSVCDDDWDVVDANVVCRQLGCGLALPVP----RPLAFGQGRGPILLDN 124

Query: 246 VACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPG-PVYAASSGQKKQQQSKPQG- 303
           V C G EA LS C    +  ++              +P  P        +    + P G 
Sbjct: 125 VECRGQEAALSECGSRGWGVHNCFHYEDVAVLCDEFLPTQPPTRKMLTSRAPPTTLPNGK 184

Query: 304 -EARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARM 362
            E  VRL GGA+  +GRVE+L +  WGTVCD  W L  A+VVCR+LG G+A  A + A  
Sbjct: 185 SEGSVRLVGGANLCQGRVEILHSGLWGTVCDDDWGLPDAAVVCRQLGCGAAMAATTNAFF 244

Query: 363 GQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNL-------------- 408
           G G G I L  V C G E  L  C        +C H +DAG  C                
Sbjct: 245 GYGTGHILLDNVHCEGGEPRLAACQSLGWGVHNCGHHEDAGALCAGLGPPTLTALPSSAT 304

Query: 409 ----------------PYTGAETRIRLSGG--RSQHEGRVEVQIGGPGPLR--------- 441
                           P    ET +  +      +  GR+ + +GGPGP R         
Sbjct: 305 REDWAWQTDPSATGVGPQPSRETALLTTAAWAAGKKSGRLRL-VGGPGPCRGRVEVLHAG 363

Query: 442 -WGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLD 500
            WG +C DDW   +A VACR+ G G A  G     ++  G    V++  V C GTE  L 
Sbjct: 364 GWGTVCDDDWDFADARVACREAGCGPAL-GATGLGHFGYGR-GPVLLDNVGCAGTEARLS 421

Query: 501 QCAH--HGTHITCKRTGTRFTAGVICS 525
            C H   G H      G    AG +C+
Sbjct: 422 DCFHLGWGQH----NCGHHEDAGALCA 444



 Score =  132 bits (333), Expect = 9e-31
 Identities = 85/250 (34%), Positives = 116/250 (46%), Gaps = 31/250 (12%)

Query: 298 QSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREAL 357
           Q  P     +RL GG     GR+EV+   +WG+VCD  WD+  A+VVCR+LG G A    
Sbjct: 49  QPTPLPFQELRLVGGPSRCRGRLEVMHGGSWGSVCDDDWDVVDANVVCRQLGCGLALPVP 108

Query: 358 SGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCN---------- 407
                GQG G I L  V C GQE +L +C  +     +C H +D  V C+          
Sbjct: 109 RPLAFGQGRGPILLDNVECRGQEAALSECGSRGWGVHNCFHYEDVAVLCDEFLPTQPPTR 168

Query: 408 -----------LPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAM 456
                      LP   +E  +RL GG +  +GRVE+   G     WG +C DDWG  +A 
Sbjct: 169 KMLTSRAPPTTLPNGKSEGSVRLVGGANLCQGRVEILHSG----LWGTVCDDDWGLPDAA 224

Query: 457 VACRQLGLGYANHGLQETWY-WDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTG 515
           V CRQLG G A       ++ + +G+I   ++  V C G E  L  C   G  +     G
Sbjct: 225 VVCRQLGCGAAMAATTNAFFGYGTGHI---LLDNVHCEGGEPRLAACQSLGWGV--HNCG 279

Query: 516 TRFTAGVICS 525
               AG +C+
Sbjct: 280 HHEDAGALCA 289



 Score =  127 bits (318), Expect = 5e-29
 Identities = 88/256 (34%), Positives = 112/256 (43%), Gaps = 27/256 (10%)

Query: 37  AGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTH 96
           AG +  R RL G P  P  GRVE+  AG WGT+CDDD+    A + CRE G   A G T 
Sbjct: 337 AGKKSGRLRLVGGPG-PCRGRVEVLHAGGWGTVCDDDWDFADARVACREAGCGPALGATG 395

Query: 97  SAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSN 156
              +G G G + LDN+ C+GTE  +++C   GWG  +C H EDAG +C      G     
Sbjct: 396 LGHFGYGRGPVLLDNVGCAGTEARLSDCFHLGWGQHNCGHHEDAGALCAGPEELGLQ--- 452

Query: 157 VIEVEHHLQVEEVRIRPAVGWGR--RPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVC 214
            ++ +          RP  G  R        EG VE+ L   W  VCD  W    + V+C
Sbjct: 453 -VQQDGSETTRVPTPRPRDGHLRLVNGAHRCEGRVELYLGQRWGTVCDDAWDLRAAGVLC 511

Query: 215 GMLGFPSEKRVNAAFYRLLAQRQQHSFG-------LHGVACVGTEAHLSLCSLEFYRAND 267
             LG            + LA   +  FG       L  V C G E+ L LCS   +   D
Sbjct: 512 RQLGCG----------QALAAPGEAHFGPGRGPILLDNVKCRGEESALLLCS---HIRWD 558

Query: 268 TARCPGGGPAVVSCVP 283
              C     A V C P
Sbjct: 559 AHNCDHSEDASVLCQP 574


>gi|67782346 lysyl oxidase-like 1 preproprotein [Homo sapiens]
          Length = 574

 Score =  222 bits (565), Expect = 1e-57
 Identities = 109/202 (53%), Positives = 133/202 (65%), Gaps = 3/202 (1%)

Query: 530 DLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSARSAN-WPYGHRRLLRFSSQIHNLG 588
           DL+     VQ + Y++   L+ L CAAEE CLAS+A +     Y  R LLRF  ++ N G
Sbjct: 371 DLVPDPNYVQASTYVQRAHLYSLRCAAEEKCLASTAYAPEATDYDVRVLLRFPQRVKNQG 430

Query: 589 RADFRPKAGRHSWVWHECHGHYHSMDIFTHYDIL-TPNGTKVAEGHKASFCLEDTECQED 647
            ADF P   RH+W WH CH HYHSMD F+HYD+L    G KVAEGHKASFCLED+ C   
Sbjct: 431 TADFLPNRPRHTWEWHSCHQHYHSMDEFSHYDLLDAATGKKVAEGHKASFCLEDSTCDFG 490

Query: 648 VSKRYECANFGEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFT 707
             KRY C +   QG++ GC+D Y  DIDCQWIDITDV+PGNYIL+V +NP + V ESDFT
Sbjct: 491 NLKRYACTSH-TQGLSPGCYDTYNADIDCQWIDITDVQPGNYILKVHVNPKYIVLESDFT 549

Query: 708 NNAMKCNCKYDGHRIWVHNCHI 729
           NN ++CN  Y G  +   NC I
Sbjct: 550 NNVVRCNIHYTGRYVSATNCKI 571


>gi|44889963 CD163 antigen isoform b [Homo sapiens]
          Length = 1121

 Score =  212 bits (539), Expect = 1e-54
 Identities = 151/504 (29%), Positives = 230/504 (45%), Gaps = 87/504 (17%)

Query: 10  SPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTI 69
           SP+ + + LL S+C  + S         G      RL     K   GRVE++   EWGT+
Sbjct: 25  SPFTITVVLLLSACFVTSS--------LGGTDKELRLVDGENK-CSGRVEVKVQEEWGTV 75

Query: 70  CDDDFTLQAAHILCRELGFT---EATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECAS 126
           C++ ++++A  ++C +LG     +A GW +S+    G+GRIW+D++SC G E ++ +C  
Sbjct: 76  CNNGWSMEAVSVICNQLGCPTAIKAPGWANSSA---GSGRIWMDHVSCRGNESALWDCKH 132

Query: 127 RGWG-NSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVT 185
            GWG +S+CTH +DAGV C D        SN+          E+R+        R   + 
Sbjct: 133 DGWGKHSNCTHQQDAGVTCSD-------GSNL----------EMRL-------TRGGNMC 168

Query: 186 EGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFG--- 242
            G +E++    W  VCD  ++  ++ V+C  L   S    + +           +FG   
Sbjct: 169 SGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGS----------SNFGEGS 218

Query: 243 ----LHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQ 298
                  + C G E+ L  C  + +  ++   C     A V C  G              
Sbjct: 219 GPIWFDDLICNGNESALWNCKHQGWGKHN---CDHAEDAGVICSKG-------------- 261

Query: 299 SKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALS 358
                +  +RL  G     GR+EV     WGT+CD  WD + A+V C++LG  +A  A+ 
Sbjct: 262 ----ADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIG 317

Query: 359 GARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIR 418
                +G G I L  V C G E ++W+C H       C+H++DAGV C+    G++  +R
Sbjct: 318 RVNASKGFGHIWLDSVSCQGHEPAVWQCKHHEWGKHYCNHNEDAGVTCS---DGSDLELR 374

Query: 419 LSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWD 478
           L GG S+  G VEV+I        G +C   WG  EA V CRQLG G A     + +   
Sbjct: 375 LRGGGSRCAGTVEVEI----QRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKI 430

Query: 479 SGNITEVVMSGVRCTGTELSLDQC 502
               T + +S   C G E SL  C
Sbjct: 431 QATNTWLFLSS--CNGNETSLWDC 452



 Score =  206 bits (523), Expect = 8e-53
 Identities = 136/416 (32%), Positives = 188/416 (45%), Gaps = 68/416 (16%)

Query: 20   CSSCLGSPSPSTGPEKKAGS--QGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQ 77
            C+S    P+  T PE+ A +  +  + RL     +   GRVEI   G WGTICDD + L 
Sbjct: 693  CNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGR-CAGRVEIYHEGSWGTICDDSWDLS 751

Query: 78   AAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHD 137
             AH++CR+LG  EA   T SA +G GTG IWLD + C+G E  + +C S GWG  +C H 
Sbjct: 752  DAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGWGQQNCRHK 811

Query: 138  EDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGW 197
            EDAGVIC +                 L++     R A            G +EV     W
Sbjct: 812  EDAGVICSEFM--------------SLRLTSEASREACA----------GRLEVFYNGAW 847

Query: 198  SQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSL 257
              V     S     VVC  LG   + ++N A                       +  +S+
Sbjct: 848  GTVGKSSMSETTVGVVCRQLGCADKGKINPA---------------------SLDKAMSI 886

Query: 258  CSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEA------RVRLKG 311
                     D  +CP G        P  ++   S   +++ + P  E       ++RL+ 
Sbjct: 887  PMWV-----DNVQCPKG--------PDTLWQCPSSPWEKRLASPSEETWITCDNKIRLQE 933

Query: 312  GAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHL 371
            G     GRVE+    +WGTVCD  WDL  A VVC++LG G A +A   A  GQG G I L
Sbjct: 934  GPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWL 993

Query: 372  SEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHE 427
            +EV+C G E SLW CP +     +C H +DA V C    +  +T  + + GRS  +
Sbjct: 994  NEVKCKGNESSLWDCPARRWGHSECGHKEDAAVNCT-DISVQKTPQKATTGRSSRQ 1048



 Score =  203 bits (516), Expect = 5e-52
 Identities = 140/463 (30%), Positives = 197/463 (42%), Gaps = 56/463 (12%)

Query: 53  PYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNL 112
           P  GRVE++    WG+ICD DF+L+AA +LCREL           A +G G G+IW +  
Sbjct: 486 PCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEF 545

Query: 113 SCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIR 172
            C G E  ++ C         C+H  D GV+C                    +  E+R+ 
Sbjct: 546 QCEGHESHLSLCPVAPRPEGTCSHSRDVGVVCS-------------------RYTEIRLV 586

Query: 173 PAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGML--GFPSEKRVNAAFY 230
                G+ P    EG VE++    W  +C+  W   ++HV+C  L  G        A F 
Sbjct: 587 N----GKTPC---EGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFG 639

Query: 231 RLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAAS 290
           +   Q  +H F      C GTE H+  C +    A   + CP    A V C        S
Sbjct: 640 KGNGQIWRHMFH-----CTGTEQHMGDCPVT---ALGASLCPSEQVASVICSGNQSQTLS 691

Query: 291 SGQKKQ----QQSKPQGEA-------RVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLH 339
           S         + + P+  A       ++RL  G     GRVE+    +WGT+CD  WDL 
Sbjct: 692 SCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSWGTICDDSWDLS 751

Query: 340 AASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHS 399
            A VVCR+LG G A  A   A  G+G G I L E++C+G+E  +W+C       ++C H 
Sbjct: 752 DAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGWGQQNCRHK 811

Query: 400 QDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVAC 459
           +DAGV C+        R+     R    GR+EV   G     WG +           V C
Sbjct: 812 EDAGVICS---EFMSLRLTSEASREACAGRLEVFYNG----AWGTVGKSSMSETTVGVVC 864

Query: 460 RQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQC 502
           RQLG   A+ G       D      + +  V+C     +L QC
Sbjct: 865 RQLGC--ADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQC 905



 Score =  198 bits (503), Expect = 2e-50
 Identities = 147/473 (31%), Positives = 205/473 (43%), Gaps = 67/473 (14%)

Query: 56  GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
           GR+EI+  G WGT+CDD+F +  A ++CR+L    A  ++ S+ +G G+G IW D+L C+
Sbjct: 170 GRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICN 229

Query: 116 GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAV 175
           G E ++  C  +GWG  +C H EDAGVIC                    +  ++ +R   
Sbjct: 230 GNESALWNCKHQGWGKHNCDHAEDAGVICS-------------------KGADLSLRLVD 270

Query: 176 GWGRRPLPVTE--GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLL 233
           G       VTE  G +EVR    W  +CD GW ++++ V C  LG P+      A  R+ 
Sbjct: 271 G-------VTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPT---AVTAIGRVN 320

Query: 234 AQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQ 293
           A +      L  V+C G E  +  C    +  +    C     A V+C  G         
Sbjct: 321 ASKGFGHIWLDSVSCQGHEPAVWQCKHHEWGKH---YCNHNEDAGVTCSDG--------- 368

Query: 294 KKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSA 353
                     +  +RL+GG     G VEV      G VCDR W L  A VVCR+LG GSA
Sbjct: 369 ---------SDLELRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSA 419

Query: 354 REALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGA 413
            +               L    C+G E SLW C +       C H ++A + C+     A
Sbjct: 420 LKTSYQVYSKIQATNTWLFLSSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCS-----A 474

Query: 414 ETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQE 473
               RL GG     GRVEV+ G      WG IC  D+    A V CR+L  G     L  
Sbjct: 475 HREPRLVGGDIPCSGRVEVKHGD----TWGSICDSDFSLEAASVLCRELQCGTVVSILGG 530

Query: 474 TWYWDSGNITEVVMSGVRCTGTELSLDQC-AHHGTHITCKRTGTRFTAGVICS 525
             ++  GN  ++     +C G E  L  C        TC  +      GV+CS
Sbjct: 531 A-HFGEGN-GQIWAEEFQCEGHESHLSLCPVAPRPEGTCSHSR---DVGVVCS 578



 Score =  166 bits (421), Expect = 6e-41
 Identities = 134/488 (27%), Positives = 204/488 (41%), Gaps = 58/488 (11%)

Query: 51   RKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLD 110
            + P EGRVE++  G WG++C+  + ++ AH+LC++L    A      A++G G G+IW  
Sbjct: 589  KTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRH 648

Query: 111  NLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSN----------VIEV 160
               C+GTEQ + +C     G S C  ++ A VIC   +    S  N          + E 
Sbjct: 649  MFHCTGTEQHMGDCPVTALGASLCPSEQVASVICSGNQSQTLSSCNSSSLGPTRPTIPEE 708

Query: 161  EHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFP 220
                 +E  ++R   G GR       G VE+     W  +CD  W   ++HVVC  LG  
Sbjct: 709  SAVACIESGQLRLVNGGGR-----CAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLG-- 761

Query: 221  SEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVS 280
              + +NA       +       L  + C G E+ +  C    +   +   C     A V 
Sbjct: 762  CGEAINATGSAHFGE-GTGPIWLDEMKCNGKESRIWQCHSHGWGQQN---CRHKEDAGVI 817

Query: 281  CVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHA 340
            C        S     +  S+   EA            GR+EV     WGTV         
Sbjct: 818  C--------SEFMSLRLTSEASREACA----------GRLEVFYNGAWGTVGKSSMSETT 859

Query: 341  ASVVCRELGFGSAREALSGARMGQGMG-AIHLSEVRCSGQELSLWKCPHKNITAEDCSHS 399
              VVCR+LG    +  ++ A + + M   + +  V+C     +LW+CP         S S
Sbjct: 860  VGVVCRQLGCAD-KGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRLASPS 918

Query: 400  QDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVAC 459
            ++  + C       + +IRL  G +   GRVE+  GG     WG +C D W   +A V C
Sbjct: 919  EETWITC-------DNKIRLQEGPTSCSGRVEIWHGG----SWGTVCDDSWDLDDAQVVC 967

Query: 460  RQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQC-AHHGTHITCKRTGTRF 518
            +QLG G A    +E  +        + ++ V+C G E SL  C A    H  C   G + 
Sbjct: 968  QQLGCGPALKAFKEAEFGQGTG--PIWLNEVKCKGNESSLWDCPARRWGHSEC---GHKE 1022

Query: 519  TAGVICSE 526
             A V C++
Sbjct: 1023 DAAVNCTD 1030



 Score =  164 bits (415), Expect = 3e-40
 Identities = 136/503 (27%), Positives = 193/503 (38%), Gaps = 92/503 (18%)

Query: 56  GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
           G VE++     G +CD  + L+ A ++CR+LG   A   ++           WL   SC+
Sbjct: 384 GTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLSSCN 443

Query: 116 GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAV 175
           G E S+ +C +  WG   C H E+A + C   R P     ++                  
Sbjct: 444 GNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDI------------------ 485

Query: 176 GWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRV--NAAFYRLL 233
                      G VEV+  D W  +CD  +S   + V+C  L   +   +   A F    
Sbjct: 486 --------PCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGN 537

Query: 234 AQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQ 293
            Q     F      C G E+HLSLC +          C       V C            
Sbjct: 538 GQIWAEEF-----QCEGHESHLSLCPVA---PRPEGTCSHSRDVGVVC------------ 577

Query: 294 KKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSA 353
                        +RL  G  P EGRVE+     WG++C+  WD+  A V+C++L  G A
Sbjct: 578 --------SRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVA 629

Query: 354 REALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCN------ 407
                GAR G+G G I      C+G E  +  CP   + A  C   Q A V C+      
Sbjct: 630 LSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASLCPSEQVASVICSGNQSQT 689

Query: 408 ---------------LPYTGAET-----RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICG 447
                          +P   A       ++RL  G  +  GRVE+   G     WG IC 
Sbjct: 690 LSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGS----WGTICD 745

Query: 448 DDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG- 506
           D W   +A V CRQLG G A +      + +      + +  ++C G E  + QC  HG 
Sbjct: 746 DSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTG--PIWLDEMKCNGKESRIWQCHSHGW 803

Query: 507 THITCKRTGTRFTAGVICSETAS 529
               C+    +  AGVICSE  S
Sbjct: 804 GQQNCRH---KEDAGVICSEFMS 823



 Score =  160 bits (406), Expect = 3e-39
 Identities = 112/349 (32%), Positives = 164/349 (46%), Gaps = 39/349 (11%)

Query: 187 GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGV 246
           G VEV++ + W  VC+ GWS     V+C  LG P+   + A  +   +      +  H V
Sbjct: 62  GRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTA--IKAPGWANSSAGSGRIWMDH-V 118

Query: 247 ACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEAR 306
           +C G E+ L  C  + +  +  + C     A V+C  G                      
Sbjct: 119 SCRGNESALWDCKHDGWGKH--SNCTHQQDAGVTCSDG------------------SNLE 158

Query: 307 VRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGM 366
           +RL  G +   GR+E+     WGTVCD  +++  ASV+CR+L  GSA      +  G+G 
Sbjct: 159 MRLTRGGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGS 218

Query: 367 GAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQH 426
           G I   ++ C+G E +LW C H+     +C H++DAGV C+    GA+  +RL  G ++ 
Sbjct: 219 GPIWFDDLICNGNESALWNCKHQGWGKHNCDHAEDAGVICS---KGADLSLRLVDGVTEC 275

Query: 427 EGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVV 486
            GR+EV+  G     WG IC D W + +A VAC+QLG   A   +       S     + 
Sbjct: 276 SGRLEVRFQG----EWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRV--NASKGFGHIW 329

Query: 487 MSGVRCTGTELSLDQCAHH--GTHITCKRTGTRFTAGVICSETASDLLL 533
           +  V C G E ++ QC HH  G H  C        AGV CS+  SDL L
Sbjct: 330 LDSVSCQGHEPAVWQCKHHEWGKHY-CNHNE---DAGVTCSD-GSDLEL 373



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 60/254 (23%), Positives = 100/254 (39%), Gaps = 40/254 (15%)

Query: 51   RKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLD 110
            R+   GR+E+   G WGT+     +     ++CR+LG  +      ++     +  +W+D
Sbjct: 832  REACAGRLEVFYNGAWGTVGKSSMSETTVGVVCRQLGCADKGKINPASLDKAMSIPMWVD 891

Query: 111  NLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVR 170
            N+ C     ++ +C S  W                ++RL   S+   I  ++ ++++E  
Sbjct: 892  NVQCPKGPDTLWQCPSSPW----------------EKRLASPSEETWITCDNKIRLQE-- 933

Query: 171  IRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGF-PSEKRVNAAF 229
              P    GR         VE+     W  VCD  W   ++ VVC  LG  P+ K    AF
Sbjct: 934  -GPTSCSGR---------VEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALK----AF 979

Query: 230  YRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSC----VPGP 285
                  +      L+ V C G E+ L  C     R    + C     A V+C    V   
Sbjct: 980  KEAEFGQGTGPIWLNEVKCKGNESSLWDCPA---RRWGHSECGHKEDAAVNCTDISVQKT 1036

Query: 286  VYAASSGQKKQQQS 299
               A++G+  +Q S
Sbjct: 1037 PQKATTGRSSRQSS 1050


>gi|44662834 CD163 antigen isoform a [Homo sapiens]
          Length = 1156

 Score =  212 bits (539), Expect = 1e-54
 Identities = 151/504 (29%), Positives = 230/504 (45%), Gaps = 87/504 (17%)

Query: 10  SPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTI 69
           SP+ + + LL S+C  + S         G      RL     K   GRVE++   EWGT+
Sbjct: 25  SPFTITVVLLLSACFVTSS--------LGGTDKELRLVDGENK-CSGRVEVKVQEEWGTV 75

Query: 70  CDDDFTLQAAHILCRELGFT---EATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECAS 126
           C++ ++++A  ++C +LG     +A GW +S+    G+GRIW+D++SC G E ++ +C  
Sbjct: 76  CNNGWSMEAVSVICNQLGCPTAIKAPGWANSSA---GSGRIWMDHVSCRGNESALWDCKH 132

Query: 127 RGWG-NSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVT 185
            GWG +S+CTH +DAGV C D        SN+          E+R+        R   + 
Sbjct: 133 DGWGKHSNCTHQQDAGVTCSD-------GSNL----------EMRL-------TRGGNMC 168

Query: 186 EGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFG--- 242
            G +E++    W  VCD  ++  ++ V+C  L   S    + +           +FG   
Sbjct: 169 SGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGS----------SNFGEGS 218

Query: 243 ----LHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQ 298
                  + C G E+ L  C  + +  ++   C     A V C  G              
Sbjct: 219 GPIWFDDLICNGNESALWNCKHQGWGKHN---CDHAEDAGVICSKG-------------- 261

Query: 299 SKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALS 358
                +  +RL  G     GR+EV     WGT+CD  WD + A+V C++LG  +A  A+ 
Sbjct: 262 ----ADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIG 317

Query: 359 GARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIR 418
                +G G I L  V C G E ++W+C H       C+H++DAGV C+    G++  +R
Sbjct: 318 RVNASKGFGHIWLDSVSCQGHEPAVWQCKHHEWGKHYCNHNEDAGVTCS---DGSDLELR 374

Query: 419 LSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWD 478
           L GG S+  G VEV+I        G +C   WG  EA V CRQLG G A     + +   
Sbjct: 375 LRGGGSRCAGTVEVEI----QRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKI 430

Query: 479 SGNITEVVMSGVRCTGTELSLDQC 502
               T + +S   C G E SL  C
Sbjct: 431 QATNTWLFLSS--CNGNETSLWDC 452



 Score =  206 bits (523), Expect = 8e-53
 Identities = 136/416 (32%), Positives = 188/416 (45%), Gaps = 68/416 (16%)

Query: 20   CSSCLGSPSPSTGPEKKAGS--QGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQ 77
            C+S    P+  T PE+ A +  +  + RL     +   GRVEI   G WGTICDD + L 
Sbjct: 693  CNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGR-CAGRVEIYHEGSWGTICDDSWDLS 751

Query: 78   AAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHD 137
             AH++CR+LG  EA   T SA +G GTG IWLD + C+G E  + +C S GWG  +C H 
Sbjct: 752  DAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGWGQQNCRHK 811

Query: 138  EDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGW 197
            EDAGVIC +                 L++     R A            G +EV     W
Sbjct: 812  EDAGVICSEFM--------------SLRLTSEASREACA----------GRLEVFYNGAW 847

Query: 198  SQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSL 257
              V     S     VVC  LG   + ++N A                       +  +S+
Sbjct: 848  GTVGKSSMSETTVGVVCRQLGCADKGKINPA---------------------SLDKAMSI 886

Query: 258  CSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEA------RVRLKG 311
                     D  +CP G        P  ++   S   +++ + P  E       ++RL+ 
Sbjct: 887  PMWV-----DNVQCPKG--------PDTLWQCPSSPWEKRLASPSEETWITCDNKIRLQE 933

Query: 312  GAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHL 371
            G     GRVE+    +WGTVCD  WDL  A VVC++LG G A +A   A  GQG G I L
Sbjct: 934  GPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWL 993

Query: 372  SEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHE 427
            +EV+C G E SLW CP +     +C H +DA V C    +  +T  + + GRS  +
Sbjct: 994  NEVKCKGNESSLWDCPARRWGHSECGHKEDAAVNCT-DISVQKTPQKATTGRSSRQ 1048



 Score =  203 bits (516), Expect = 5e-52
 Identities = 140/463 (30%), Positives = 197/463 (42%), Gaps = 56/463 (12%)

Query: 53  PYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNL 112
           P  GRVE++    WG+ICD DF+L+AA +LCREL           A +G G G+IW +  
Sbjct: 486 PCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEF 545

Query: 113 SCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIR 172
            C G E  ++ C         C+H  D GV+C                    +  E+R+ 
Sbjct: 546 QCEGHESHLSLCPVAPRPEGTCSHSRDVGVVCS-------------------RYTEIRLV 586

Query: 173 PAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGML--GFPSEKRVNAAFY 230
                G+ P    EG VE++    W  +C+  W   ++HV+C  L  G        A F 
Sbjct: 587 N----GKTPC---EGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFG 639

Query: 231 RLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAAS 290
           +   Q  +H F      C GTE H+  C +    A   + CP    A V C        S
Sbjct: 640 KGNGQIWRHMFH-----CTGTEQHMGDCPVT---ALGASLCPSEQVASVICSGNQSQTLS 691

Query: 291 SGQKKQ----QQSKPQGEA-------RVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLH 339
           S         + + P+  A       ++RL  G     GRVE+    +WGT+CD  WDL 
Sbjct: 692 SCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSWGTICDDSWDLS 751

Query: 340 AASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHS 399
            A VVCR+LG G A  A   A  G+G G I L E++C+G+E  +W+C       ++C H 
Sbjct: 752 DAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGWGQQNCRHK 811

Query: 400 QDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVAC 459
           +DAGV C+        R+     R    GR+EV   G     WG +           V C
Sbjct: 812 EDAGVICS---EFMSLRLTSEASREACAGRLEVFYNG----AWGTVGKSSMSETTVGVVC 864

Query: 460 RQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQC 502
           RQLG   A+ G       D      + +  V+C     +L QC
Sbjct: 865 RQLGC--ADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQC 905



 Score =  198 bits (503), Expect = 2e-50
 Identities = 147/473 (31%), Positives = 205/473 (43%), Gaps = 67/473 (14%)

Query: 56  GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
           GR+EI+  G WGT+CDD+F +  A ++CR+L    A  ++ S+ +G G+G IW D+L C+
Sbjct: 170 GRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICN 229

Query: 116 GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAV 175
           G E ++  C  +GWG  +C H EDAGVIC                    +  ++ +R   
Sbjct: 230 GNESALWNCKHQGWGKHNCDHAEDAGVICS-------------------KGADLSLRLVD 270

Query: 176 GWGRRPLPVTE--GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLL 233
           G       VTE  G +EVR    W  +CD GW ++++ V C  LG P+      A  R+ 
Sbjct: 271 G-------VTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPT---AVTAIGRVN 320

Query: 234 AQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQ 293
           A +      L  V+C G E  +  C    +  +    C     A V+C  G         
Sbjct: 321 ASKGFGHIWLDSVSCQGHEPAVWQCKHHEWGKH---YCNHNEDAGVTCSDG--------- 368

Query: 294 KKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSA 353
                     +  +RL+GG     G VEV      G VCDR W L  A VVCR+LG GSA
Sbjct: 369 ---------SDLELRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSA 419

Query: 354 REALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGA 413
            +               L    C+G E SLW C +       C H ++A + C+     A
Sbjct: 420 LKTSYQVYSKIQATNTWLFLSSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCS-----A 474

Query: 414 ETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQE 473
               RL GG     GRVEV+ G      WG IC  D+    A V CR+L  G     L  
Sbjct: 475 HREPRLVGGDIPCSGRVEVKHGD----TWGSICDSDFSLEAASVLCRELQCGTVVSILGG 530

Query: 474 TWYWDSGNITEVVMSGVRCTGTELSLDQC-AHHGTHITCKRTGTRFTAGVICS 525
             ++  GN  ++     +C G E  L  C        TC  +      GV+CS
Sbjct: 531 A-HFGEGN-GQIWAEEFQCEGHESHLSLCPVAPRPEGTCSHSR---DVGVVCS 578



 Score =  166 bits (421), Expect = 6e-41
 Identities = 134/488 (27%), Positives = 204/488 (41%), Gaps = 58/488 (11%)

Query: 51   RKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLD 110
            + P EGRVE++  G WG++C+  + ++ AH+LC++L    A      A++G G G+IW  
Sbjct: 589  KTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRH 648

Query: 111  NLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSN----------VIEV 160
               C+GTEQ + +C     G S C  ++ A VIC   +    S  N          + E 
Sbjct: 649  MFHCTGTEQHMGDCPVTALGASLCPSEQVASVICSGNQSQTLSSCNSSSLGPTRPTIPEE 708

Query: 161  EHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFP 220
                 +E  ++R   G GR       G VE+     W  +CD  W   ++HVVC  LG  
Sbjct: 709  SAVACIESGQLRLVNGGGR-----CAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLG-- 761

Query: 221  SEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVS 280
              + +NA       +       L  + C G E+ +  C    +   +   C     A V 
Sbjct: 762  CGEAINATGSAHFGE-GTGPIWLDEMKCNGKESRIWQCHSHGWGQQN---CRHKEDAGVI 817

Query: 281  CVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHA 340
            C        S     +  S+   EA            GR+EV     WGTV         
Sbjct: 818  C--------SEFMSLRLTSEASREACA----------GRLEVFYNGAWGTVGKSSMSETT 859

Query: 341  ASVVCRELGFGSAREALSGARMGQGMG-AIHLSEVRCSGQELSLWKCPHKNITAEDCSHS 399
              VVCR+LG    +  ++ A + + M   + +  V+C     +LW+CP         S S
Sbjct: 860  VGVVCRQLGCAD-KGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRLASPS 918

Query: 400  QDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVAC 459
            ++  + C       + +IRL  G +   GRVE+  GG     WG +C D W   +A V C
Sbjct: 919  EETWITC-------DNKIRLQEGPTSCSGRVEIWHGG----SWGTVCDDSWDLDDAQVVC 967

Query: 460  RQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQC-AHHGTHITCKRTGTRF 518
            +QLG G A    +E  +        + ++ V+C G E SL  C A    H  C   G + 
Sbjct: 968  QQLGCGPALKAFKEAEFGQGTG--PIWLNEVKCKGNESSLWDCPARRWGHSEC---GHKE 1022

Query: 519  TAGVICSE 526
             A V C++
Sbjct: 1023 DAAVNCTD 1030



 Score =  164 bits (415), Expect = 3e-40
 Identities = 136/503 (27%), Positives = 193/503 (38%), Gaps = 92/503 (18%)

Query: 56  GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
           G VE++     G +CD  + L+ A ++CR+LG   A   ++           WL   SC+
Sbjct: 384 GTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLSSCN 443

Query: 116 GTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAV 175
           G E S+ +C +  WG   C H E+A + C   R P     ++                  
Sbjct: 444 GNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDI------------------ 485

Query: 176 GWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRV--NAAFYRLL 233
                      G VEV+  D W  +CD  +S   + V+C  L   +   +   A F    
Sbjct: 486 --------PCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGN 537

Query: 234 AQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQ 293
            Q     F      C G E+HLSLC +          C       V C            
Sbjct: 538 GQIWAEEF-----QCEGHESHLSLCPVA---PRPEGTCSHSRDVGVVC------------ 577

Query: 294 KKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSA 353
                        +RL  G  P EGRVE+     WG++C+  WD+  A V+C++L  G A
Sbjct: 578 --------SRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVA 629

Query: 354 REALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCN------ 407
                GAR G+G G I      C+G E  +  CP   + A  C   Q A V C+      
Sbjct: 630 LSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASLCPSEQVASVICSGNQSQT 689

Query: 408 ---------------LPYTGAET-----RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICG 447
                          +P   A       ++RL  G  +  GRVE+   G     WG IC 
Sbjct: 690 LSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGS----WGTICD 745

Query: 448 DDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG- 506
           D W   +A V CRQLG G A +      + +      + +  ++C G E  + QC  HG 
Sbjct: 746 DSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTG--PIWLDEMKCNGKESRIWQCHSHGW 803

Query: 507 THITCKRTGTRFTAGVICSETAS 529
               C+    +  AGVICSE  S
Sbjct: 804 GQQNCRH---KEDAGVICSEFMS 823



 Score =  160 bits (406), Expect = 3e-39
 Identities = 112/349 (32%), Positives = 164/349 (46%), Gaps = 39/349 (11%)

Query: 187 GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGV 246
           G VEV++ + W  VC+ GWS     V+C  LG P+   + A  +   +      +  H V
Sbjct: 62  GRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTA--IKAPGWANSSAGSGRIWMDH-V 118

Query: 247 ACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEAR 306
           +C G E+ L  C  + +  +  + C     A V+C  G                      
Sbjct: 119 SCRGNESALWDCKHDGWGKH--SNCTHQQDAGVTCSDG------------------SNLE 158

Query: 307 VRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGM 366
           +RL  G +   GR+E+     WGTVCD  +++  ASV+CR+L  GSA      +  G+G 
Sbjct: 159 MRLTRGGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGS 218

Query: 367 GAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQH 426
           G I   ++ C+G E +LW C H+     +C H++DAGV C+    GA+  +RL  G ++ 
Sbjct: 219 GPIWFDDLICNGNESALWNCKHQGWGKHNCDHAEDAGVICS---KGADLSLRLVDGVTEC 275

Query: 427 EGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVV 486
            GR+EV+  G     WG IC D W + +A VAC+QLG   A   +       S     + 
Sbjct: 276 SGRLEVRFQG----EWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRV--NASKGFGHIW 329

Query: 487 MSGVRCTGTELSLDQCAHH--GTHITCKRTGTRFTAGVICSETASDLLL 533
           +  V C G E ++ QC HH  G H  C        AGV CS+  SDL L
Sbjct: 330 LDSVSCQGHEPAVWQCKHHEWGKHY-CNHNE---DAGVTCSD-GSDLEL 373



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 60/254 (23%), Positives = 100/254 (39%), Gaps = 40/254 (15%)

Query: 51   RKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLD 110
            R+   GR+E+   G WGT+     +     ++CR+LG  +      ++     +  +W+D
Sbjct: 832  REACAGRLEVFYNGAWGTVGKSSMSETTVGVVCRQLGCADKGKINPASLDKAMSIPMWVD 891

Query: 111  NLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVR 170
            N+ C     ++ +C S  W                ++RL   S+   I  ++ ++++E  
Sbjct: 892  NVQCPKGPDTLWQCPSSPW----------------EKRLASPSEETWITCDNKIRLQE-- 933

Query: 171  IRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGF-PSEKRVNAAF 229
              P    GR         VE+     W  VCD  W   ++ VVC  LG  P+ K    AF
Sbjct: 934  -GPTSCSGR---------VEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALK----AF 979

Query: 230  YRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSC----VPGP 285
                  +      L+ V C G E+ L  C     R    + C     A V+C    V   
Sbjct: 980  KEAEFGQGTGPIWLNEVKCKGNESSLWDCPA---RRWGHSECGHKEDAAVNCTDISVQKT 1036

Query: 286  VYAASSGQKKQQQS 299
               A++G+  +Q S
Sbjct: 1037 PQKATTGRSSRQSS 1050


>gi|4506143 neurotrypsin precursor [Homo sapiens]
          Length = 875

 Score =  211 bits (536), Expect = 3e-54
 Identities = 136/405 (33%), Positives = 190/405 (46%), Gaps = 50/405 (12%)

Query: 45  RLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGT 104
           RLAG     +EGRVE+  AG+WGT+CDD +    A ++CR+LG +      H A +G G+
Sbjct: 281 RLAG-GSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGS 339

Query: 105 GRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHL 164
           G + LD + C+G E S+ +C    WG  +C H EDAGV C                    
Sbjct: 340 GPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC-------------------T 380

Query: 165 QVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKR 224
            + +  IR A G G       EG +EV     W  VCD GW+  N++VVC  LGF   K+
Sbjct: 381 PLTDGVIRLAGGKGSH-----EGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQ 435

Query: 225 VNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPG 284
            +A  +    +       L  V+C G E     CS   +  +D   C       ++C PG
Sbjct: 436 ASANHF----EESTGPIWLDDVSCSGKETRFLQCSRRQWGRHD---CSHREDVSIACYPG 488

Query: 285 PVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVV 344
                  G +            VRL  G +  EGRVEV     WGT+CD  W    A+V+
Sbjct: 489 -----GEGHRLSLGFP------VRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVI 537

Query: 345 CRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGV 404
           CR+LG+     A + A  G+G G IH+  V+C+G E SL  C  ++I   +C HS+DAGV
Sbjct: 538 CRQLGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGV 597

Query: 405 RCNL------PYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWG 443
            C+         +  E+   + G R  H  +  + IGG   LR G
Sbjct: 598 ICDYFGKKASGNSNKESLSSVCGLRLLHRRQKRI-IGGKNSLRGG 641



 Score =  183 bits (465), Expect = 4e-46
 Identities = 146/487 (29%), Positives = 197/487 (40%), Gaps = 76/487 (15%)

Query: 51  RKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTG----R 106
           +  +EG VE+  +G WGT+C   +    A ++C +L      G    AK  P +G     
Sbjct: 176 KNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQL----QLGGKGIAKQTPFSGLGLIP 231

Query: 107 IWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQV 166
           I+  N+ C G E+++  C    W    C     A V C     P F              
Sbjct: 232 IYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSHGPTFP------------- 278

Query: 167 EEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVN 226
               IR A G       V EG VE+     W  VCD  W   ++ V+C  LG      + 
Sbjct: 279 ---IIRLAGG-----SSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSG---IA 327

Query: 227 AAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPV 286
            A+++           L  V C G E  +  C    +  ++   C     A VSC     
Sbjct: 328 KAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCPKSSWGEHN---CGHKEDAGVSCT---- 380

Query: 287 YAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCR 346
                         P  +  +RL GG    EGR+EV     WGTVCD  W      VVCR
Sbjct: 381 --------------PLTDGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCR 426

Query: 347 ELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC 406
           +LGF   ++A S     +  G I L +V CSG+E    +C  +     DCSH +D  + C
Sbjct: 427 QLGFKYGKQA-SANHFEESTGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIAC 485

Query: 407 NLPYTGAETR-------IRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVAC 459
              Y G E         +RL  G ++ EGRVEV I G    +WG IC D W   +A V C
Sbjct: 486 ---YPGGEGHRLSLGFPVRLMDGENKKEGRVEVFING----QWGTICDDGWTDKDAAVIC 538

Query: 460 RQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHH--GTHITCKRTGTR 517
           RQ  LGY       T  +       + +  V+CTG E SL  C     G H  C+ +   
Sbjct: 539 RQ--LGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRH-NCRHSE-- 593

Query: 518 FTAGVIC 524
             AGVIC
Sbjct: 594 -DAGVIC 599



 Score =  138 bits (347), Expect = 2e-32
 Identities = 86/224 (38%), Positives = 113/224 (50%), Gaps = 18/224 (8%)

Query: 307 VRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGM 366
           VRL+GG +  EG VEV  +  WGTVC   WD   ASV+C +L  G    A      G G+
Sbjct: 170 VRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGL 229

Query: 367 GAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQH 426
             I+ S VRC G E ++  C         C     A V C+  +      IRL+GG S H
Sbjct: 230 IPIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSHGPTFPIIRLAGGSSVH 289

Query: 427 EGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETW---YWDSGNIT 483
           EGRVE+   G    +WG +C D W   +A V CRQLGL     G+ + W   Y+  G+  
Sbjct: 290 EGRVELYHAG----QWGTVCDDQWDDADAEVICRQLGLS----GIAKAWHQAYFGEGS-G 340

Query: 484 EVVMSGVRCTGTELSLDQC--AHHGTHITCKRTGTRFTAGVICS 525
            V++  VRCTG ELS++QC  +  G H      G +  AGV C+
Sbjct: 341 PVMLDEVRCTGNELSIEQCPKSSWGEH----NCGHKEDAGVSCT 380


>gi|222352122 hypothetical protein LOC284297 [Homo sapiens]
          Length = 1573

 Score =  196 bits (498), Expect = 7e-50
 Identities = 168/563 (29%), Positives = 216/563 (38%), Gaps = 137/563 (24%)

Query: 43  RFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGP 102
           R RLA  P     GR+E+   G WGT+CDD + L+ A + CR+LG   A      A +G 
Sbjct: 19  RLRLADGPHG-CAGRLEVWHGGRWGTVCDDGWDLRDAAVACRQLGCGGALAAPGGAFFGE 77

Query: 103 GTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNV----- 157
           G G +WL  L+C G E  +  C  RGW    C+H+EDAGV+C  QR+    D +      
Sbjct: 78  GAGPVWLSELACRGNEGQLGLCHHRGWKAHICSHEEDAGVVCAGQRVANSRDDSTSPLDG 137

Query: 158 -----IEVEHHLQVEEVRI----RPA----------------VGWGRRPLPVT------- 185
                + +E     EE  +    RPA                    R PL  T       
Sbjct: 138 APWPGLLLELSPSTEEPLVTHAPRPAGNPQNASRKKSPRPKQAKSTRAPLLTTGAPRQER 197

Query: 186 ----------EGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQ 235
                      G +EV     W  VCD GW   ++ V C  LG              LA 
Sbjct: 198 LRLVSGPHRCAGRLEVWHGGRWGTVCDDGWDLRDAAVACRELGCGG----------ALAA 247

Query: 236 RQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKK 295
                FG  G   V                 D   C GG  A+  C   P   ++    +
Sbjct: 248 PGGARFG-PGAGPVWM---------------DDVGCGGGEQALRDCPRSPWGRSNCDHSE 291

Query: 296 QQQSKPQGEA-RVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAR 354
                  G A R+RL  G H   GR+EV     WG+VCD  WDL  A+V CRELG G A 
Sbjct: 292 DAGLVCTGPAPRLRLADGPHGCAGRLEVWHGGRWGSVCDDAWDLRDAAVACRELGCGGAL 351

Query: 355 EALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCN------- 407
            A  GA  G+G G I L ++RC G E +L  CP +     DC H +DAG  C+       
Sbjct: 352 AAPGGAFFGEGSGPIILDDLRCRGNETALRFCPARPWGQHDCHHREDAGAVCDGMPLGYV 411

Query: 408 ---LPYTGAETRIRLSGGR------SQHEGRVEVQ--------IGGPGP----------- 439
               P     +  R +  R      SQ  G   V         +  PGP           
Sbjct: 412 PPTAPTDSNNSTPREAASRPPSTMTSQAPGTAGVSPPPASPTVLWEPGPEAGSPQLRLVA 471

Query: 440 --------------LRWGLICGDDWGTLEAMVACRQLGLGYANHGLQE------TWYWDS 479
                          RWG +C D W   ++ V CR+LG G    G Q+       + W +
Sbjct: 472 GPSKCSGRLEVWHDQRWGTVCDDSWDMRDSAVVCRELGCG----GPQQPDPAAGRFGWGA 527

Query: 480 GNITEVVMSGVRCTGTELSLDQC 502
           G I    +  V C GTE SL  C
Sbjct: 528 GPIW---LDDVGCVGTEASLSDC 547



 Score =  173 bits (439), Expect = 5e-43
 Identities = 124/405 (30%), Positives = 165/405 (40%), Gaps = 69/405 (17%)

Query: 43  RFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGP 102
           R RL   P +   GR+E+   G WGT+CDD + L+ A + CRELG   A      A++GP
Sbjct: 197 RLRLVSGPHR-CAGRLEVWHGGRWGTVCDDGWDLRDAAVACRELGCGGALAAPGGARFGP 255

Query: 103 GTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEH 162
           G G +W+D++ C G EQ++ +C    WG S+C H EDAG++C                  
Sbjct: 256 GAGPVWMDDVGCGGGEQALRDCPRSPWGRSNCDHSEDAGLVCTG---------------- 299

Query: 163 HLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSE 222
                  R+R A G          G +EV     W  VCD  W   ++ V C  LG    
Sbjct: 300 ----PAPRLRLADG-----PHGCAGRLEVWHGGRWGSVCDDAWDLRDAAVACRELGCGGA 350

Query: 223 KRV-NAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSC 281
                 AF+            L  + C G E  L  C    +  +D       G AV   
Sbjct: 351 LAAPGGAFF----GEGSGPIILDDLRCRGNETALRFCPARPWGQHDCHHREDAG-AVCDG 405

Query: 282 VP---------------GPVYAASSGQKKQQQSKP---------------------QGEA 305
           +P                P  AAS          P                      G  
Sbjct: 406 MPLGYVPPTAPTDSNNSTPREAASRPPSTMTSQAPGTAGVSPPPASPTVLWEPGPEAGSP 465

Query: 306 RVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGA-RMGQ 364
           ++RL  G     GR+EV     WGTVCD  WD+  ++VVCRELG G  ++    A R G 
Sbjct: 466 QLRLVAGPSKCSGRLEVWHDQRWGTVCDDSWDMRDSAVVCRELGCGGPQQPDPAAGRFGW 525

Query: 365 GMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLP 409
           G G I L +V C G E SL  CP       +C+H++D GV C  P
Sbjct: 526 GAGPIWLDDVGCVGTEASLSDCPAAPWGKHNCAHNEDVGVTCTGP 570



 Score =  157 bits (398), Expect = 3e-38
 Identities = 121/394 (30%), Positives = 162/394 (41%), Gaps = 77/394 (19%)

Query: 187 GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRV-NAAFYRLLAQRQQHSFGLHG 245
           G +EV     W  VCD GW   ++ V C  LG          AF+   A        L  
Sbjct: 31  GRLEVWHGGRWGTVCDDGWDLRDAAVACRQLGCGGALAAPGGAFFGEGAG----PVWLSE 86

Query: 246 VACVGTEAHLSLCSLEFYRANDTAR-------CPG---------------GGP------- 276
           +AC G E  L LC    ++A+  +        C G               G P       
Sbjct: 87  LACRGNEGQLGLCHHRGWKAHICSHEEDAGVVCAGQRVANSRDDSTSPLDGAPWPGLLLE 146

Query: 277 -------AVVSCVPGPVYAASSGQKKQQQSKPQGEA--------------RVRLKGGAHP 315
                   +V+  P P     +  +K+     Q ++              R+RL  G H 
Sbjct: 147 LSPSTEEPLVTHAPRPAGNPQNASRKKSPRPKQAKSTRAPLLTTGAPRQERLRLVSGPHR 206

Query: 316 GEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVR 375
             GR+EV     WGTVCD  WDL  A+V CRELG G A  A  GAR G G G + + +V 
Sbjct: 207 CAGRLEVWHGGRWGTVCDDGWDLRDAAVACRELGCGGALAAPGGARFGPGAGPVWMDDVG 266

Query: 376 CSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIG 435
           C G E +L  CP       +C HS+DAG+ C    TG   R+RL+ G     GR+EV  G
Sbjct: 267 CGGGEQALRDCPRSPWGRSNCDHSEDAGLVC----TGPAPRLRLADGPHGCAGRLEVWHG 322

Query: 436 GPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGT 495
           G    RWG +C D W   +A VACR+LG G A       ++ +      +++  +RC G 
Sbjct: 323 G----RWGSVCDDAWDLRDAAVACRELGCGGALAAPGGAFFGEGSG--PIILDDLRCRGN 376

Query: 496 ELSLDQC-----AHHGTHITCKRTGTRFTAGVIC 524
           E +L  C       H  H        R  AG +C
Sbjct: 377 ETALRFCPARPWGQHDCH-------HREDAGAVC 403



 Score =  109 bits (273), Expect = 8e-24
 Identities = 91/289 (31%), Positives = 117/289 (40%), Gaps = 61/289 (21%)

Query: 10  SPWGLLLC-------LLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQR 62
           SPWG   C       L+C+     P+P             R RLA  P     GR+E+  
Sbjct: 280 SPWGRSNCDHSEDAGLVCTG----PAP-------------RLRLADGPHG-CAGRLEVWH 321

Query: 63  AGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVT 122
            G WG++CDD + L+ A + CRELG   A      A +G G+G I LD+L C G E ++ 
Sbjct: 322 GGRWGSVCDDAWDLRDAAVACRELGCGGALAAPGGAFFGEGSGPIILDDLRCRGNETALR 381

Query: 123 ECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRP-------AV 175
            C +R WG  DC H EDAG +C    L G+         ++    E   RP       A 
Sbjct: 382 FCPARPWGQHDCHHREDAGAVCDGMPL-GYVPPTAPTDSNNSTPREAASRPPSTMTSQAP 440

Query: 176 GW-GRRPLPVT-------------------------EGLVEVRLPDGWSQVCDKGWSAHN 209
           G  G  P P +                          G +EV     W  VCD  W   +
Sbjct: 441 GTAGVSPPPASPTVLWEPGPEAGSPQLRLVAGPSKCSGRLEVWHDQRWGTVCDDSWDMRD 500

Query: 210 SHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLC 258
           S VVC  LG    ++ + A  R           L  V CVGTEA LS C
Sbjct: 501 SAVVCRELGCGGPQQPDPAAGRF--GWGAGPIWLDDVGCVGTEASLSDC 547



 Score =  109 bits (272), Expect = 1e-23
 Identities = 51/119 (42%), Positives = 72/119 (60%), Gaps = 3/119 (2%)

Query: 26  SPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRE 85
           +PSPS     ++G    R RLA  P +   GR+E+  AG WGT+CDD++ L+ A + C E
Sbjct: 756 APSPSVSTTGESGL--FRVRLADGPNR-CAGRLEVWHAGRWGTVCDDNWDLRDATVACWE 812

Query: 86  LGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVIC 144
           LG  +         YGPGTG IWLD++ C G+E S+++C S  WG  +C H+ED G+ C
Sbjct: 813 LGCGKVRPRVGKTHYGPGTGPIWLDDMGCKGSEASLSDCPSGAWGKHNCDHEEDVGLTC 871



 Score =  102 bits (253), Expect = 2e-21
 Identities = 51/105 (48%), Positives = 60/105 (57%)

Query: 302 QGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGAR 361
           Q   R+RL  G H   GR+EV     WGTVCD  WDL  A+V CR+LG G A  A  GA 
Sbjct: 15  QAVERLRLADGPHGCAGRLEVWHGGRWGTVCDDGWDLRDAAVACRQLGCGGALAAPGGAF 74

Query: 362 MGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC 406
            G+G G + LSE+ C G E  L  C H+   A  CSH +DAGV C
Sbjct: 75  FGEGAGPVWLSELACRGNEGQLGLCHHRGWKAHICSHEEDAGVVC 119



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 48/120 (40%), Positives = 70/120 (58%), Gaps = 4/120 (3%)

Query: 26  SPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRE 85
           SP+    P  +AGS  LR  L   P K   GR+E+     WGT+CDD + ++ + ++CRE
Sbjct: 451 SPTVLWEPGPEAGSPQLR--LVAGPSK-CSGRLEVWHDQRWGTVCDDSWDMRDSAVVCRE 507

Query: 86  LGFTEATGWTHSA-KYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVIC 144
           LG         +A ++G G G IWLD++ C GTE S+++C +  WG  +C H+ED GV C
Sbjct: 508 LGCGGPQQPDPAAGRFGWGAGPIWLDDVGCVGTEASLSDCPAAPWGKHNCAHNEDVGVTC 567



 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 45/104 (43%), Positives = 54/104 (51%)

Query: 303 GEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARM 362
           G  RVRL  G +   GR+EV  A  WGTVCD  WDL  A+V C ELG G  R  +     
Sbjct: 768 GLFRVRLADGPNRCAGRLEVWHAGRWGTVCDDNWDLRDATVACWELGCGKVRPRVGKTHY 827

Query: 363 GQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC 406
           G G G I L ++ C G E SL  CP       +C H +D G+ C
Sbjct: 828 GPGTGPIWLDDMGCKGSEASLSDCPSGAWGKHNCDHEEDVGLTC 871



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 42/115 (36%), Positives = 54/115 (46%), Gaps = 12/115 (10%)

Query: 413 AETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQ 472
           A  R+RL+ G     GR+EV  GG    RWG +C D W   +A VACRQLG G A     
Sbjct: 16  AVERLRLADGPHGCAGRLEVWHGG----RWGTVCDDGWDLRDAAVACRQLGCGGALAAPG 71

Query: 473 ETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHG--THITCKRTGTRFTAGVICS 525
             ++ +      V +S + C G E  L  C H G   HI          AGV+C+
Sbjct: 72  GAFFGEGAG--PVWLSELACRGNEGQLGLCHHRGWKAHICSHEE----DAGVVCA 120



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 30/87 (34%), Positives = 45/87 (51%), Gaps = 6/87 (6%)

Query: 416 RIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETW 475
           R+RL+ G ++  GR+EV   G    RWG +C D+W   +A VAC +LG G     + +T 
Sbjct: 771 RVRLADGPNRCAGRLEVWHAG----RWGTVCDDNWDLRDATVACWELGCGKVRPRVGKTH 826

Query: 476 YWDSGNITEVVMSGVRCTGTELSLDQC 502
           Y        + +  + C G+E SL  C
Sbjct: 827 Y--GPGTGPIWLDDMGCKGSEASLSDC 851



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 27/88 (30%), Positives = 32/88 (36%), Gaps = 20/88 (22%)

Query: 187 GLVEVRLPDG---------------WSQVCDKGWSAHNSHVVCGMLGFPSEK-RVNAAFY 230
           GL  VRL DG               W  VCD  W   ++ V C  LG    + RV    Y
Sbjct: 768 GLFRVRLADGPNRCAGRLEVWHAGRWGTVCDDNWDLRDATVACWELGCGKVRPRVGKTHY 827

Query: 231 RLLAQRQQHSFGLHGVACVGTEAHLSLC 258
                       L  + C G+EA LS C
Sbjct: 828 ----GPGTGPIWLDDMGCKGSEASLSDC 851


>gi|5174411 CD5 molecule-like [Homo sapiens]
          Length = 347

 Score =  169 bits (427), Expect = 1e-41
 Identities = 129/408 (31%), Positives = 185/408 (45%), Gaps = 78/408 (19%)

Query: 14  LLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDD 73
           LL  L+ + C       T P   A   G+R  + G  R   EGRVE+++ G+WGT+CDD 
Sbjct: 3   LLFSLILAIC-------TRPGFLASPSGVRL-VGGLHR--CEGRVEVEQKGQWGTVCDDG 52

Query: 74  FTLQAAHILCRELGFTEATGWTHSAKYGPGTGR---IWLDNLSCSGTEQSVTECASRGWG 130
           + ++   +LCRELG   A+G      Y P   +   + + ++SC+GTE ++ +C      
Sbjct: 53  WDIKDVAVLCRELGCGAASGTPSGILYEPPAEKEQKVLIQSVSCTGTEDTLAQCEQEEV- 111

Query: 131 NSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVE 190
             DC+HDEDAG  C++   P  S S V E           +R A G G       +G VE
Sbjct: 112 -YDCSHDEDAGASCEN---PESSFSPVPE----------GVRLADGPGH-----CKGRVE 152

Query: 191 VRLPDGWSQVCDKGWSAHNSHVVCGMLGFP----SEKRVNAAFYRLLAQRQQHSFG---- 242
           V+  + W  VC  GWS   + VVC  LG      ++KR N           +H++G    
Sbjct: 153 VKHQNQWYTVCQTGWSLRAAKVVCRQLGCGRAVLTQKRCN-----------KHAYGRKPI 201

Query: 243 -LHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKP 301
            L  ++C G EA L                         C  GP    +    +    + 
Sbjct: 202 WLSQMSCSGREATLQ-----------------------DCPSGPWGKNTCNHDEDTWVEC 238

Query: 302 QGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGAR 361
           +    +RL GG +   GR+EVL    WG+VCD  W      VVC++LG G +       R
Sbjct: 239 EDPFDLRLVGGDNLCSGRLEVLHKGVWGSVCDDNWGEKEDQVVCKQLGCGKSLSPSFRDR 298

Query: 362 M--GQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCN 407
              G G+G I L  VRCSG+E SL +C H+     DC+H +D  V C+
Sbjct: 299 KCYGPGVGRIWLDNVRCSGEEQSLEQCQHRFWGFHDCTHQEDVAVICS 346



 Score =  152 bits (384), Expect = 1e-36
 Identities = 109/324 (33%), Positives = 150/324 (46%), Gaps = 35/324 (10%)

Query: 186 EGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRV-NAAFYRLLAQRQQHSFGLH 244
           EG VEV     W  VCD GW   +  V+C  LG  +     +   Y   A+++Q    + 
Sbjct: 34  EGRVEVEQKGQWGTVCDDGWDIKDVAVLCRELGCGAASGTPSGILYEPPAEKEQKVL-IQ 92

Query: 245 GVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGE 304
            V+C GTE  L+ C  E     +   C     A  SC           +  +    P  E
Sbjct: 93  SVSCTGTEDTLAQCEQE-----EVYDCSHDEDAGASC-----------ENPESSFSPVPE 136

Query: 305 ARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQ 364
             VRL  G    +GRVEV   + W TVC   W L AA VVCR+LG G  R  L+  R  +
Sbjct: 137 G-VRLADGPGHCKGRVEVKHQNQWYTVCQTGWSLRAAKVVCRQLGCG--RAVLTQKRCNK 193

Query: 365 ---GMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSG 421
              G   I LS++ CSG+E +L  CP        C+H +D  V C  P+      +RL G
Sbjct: 194 HAYGRKPIWLSQMSCSGREATLQDCPSGPWGKNTCNHDEDTWVECEDPFD-----LRLVG 248

Query: 422 GRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYA-NHGLQETWYWDSG 480
           G +   GR+EV   G     WG +C D+WG  E  V C+QLG G + +   ++   +  G
Sbjct: 249 GDNLCSGRLEVLHKGV----WGSVCDDNWGEKEDQVVCKQLGCGKSLSPSFRDRKCYGPG 304

Query: 481 NITEVVMSGVRCTGTELSLDQCAH 504
            +  + +  VRC+G E SL+QC H
Sbjct: 305 -VGRIWLDNVRCSGEEQSLEQCQH 327



 Score =  113 bits (283), Expect = 6e-25
 Identities = 72/202 (35%), Positives = 101/202 (50%), Gaps = 13/202 (6%)

Query: 307 VRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARM---G 363
           VRL GG H  EGRVEV +   WGTVCD  WD+   +V+CRELG G+A    SG       
Sbjct: 24  VRLVGGLHRCEGRVEVEQKGQWGTVCDDGWDIKDVAVLCRELGCGAASGTPSGILYEPPA 83

Query: 364 QGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLP---YTGAETRIRLS 420
           +    + +  V C+G E +L +C  + +   DCSH +DAG  C  P   ++     +RL+
Sbjct: 84  EKEQKVLIQSVSCTGTEDTLAQCEQEEV--YDCSHDEDAGASCENPESSFSPVPEGVRLA 141

Query: 421 GGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSG 480
            G    +GRVEV+       +W  +C   W    A V CRQLG G A    Q+     + 
Sbjct: 142 DGPGHCKGRVEVKHQN----QWYTVCQTGWSLRAAKVVCRQLGCGRAVL-TQKRCNKHAY 196

Query: 481 NITEVVMSGVRCTGTELSLDQC 502
               + +S + C+G E +L  C
Sbjct: 197 GRKPIWLSQMSCSGREATLQDC 218



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 36/99 (36%), Positives = 51/99 (51%), Gaps = 6/99 (6%)

Query: 406 CNLP-YTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGL 464
           C  P +  + + +RL GG  + EGRVEV+  G    +WG +C D W   +  V CR+LG 
Sbjct: 12  CTRPGFLASPSGVRLVGGLHRCEGRVEVEQKG----QWGTVCDDGWDIKDVAVLCRELGC 67

Query: 465 GYANHGLQETWYWDSGNITE-VVMSGVRCTGTELSLDQC 502
           G A+       Y       + V++  V CTGTE +L QC
Sbjct: 68  GAASGTPSGILYEPPAEKEQKVLIQSVSCTGTEDTLAQC 106


>gi|239752563 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 343

 Score =  160 bits (404), Expect = 5e-39
 Identities = 107/275 (38%), Positives = 135/275 (49%), Gaps = 34/275 (12%)

Query: 307 VRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGM 366
           +RL  G    +GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A   AR GQG 
Sbjct: 18  LRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGS 77

Query: 367 GAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCN--LPYTGAETR-------- 416
           G I L +VRCSG E  LW CPH    + +C HS+DAGV C+   P T    R        
Sbjct: 78  GPIVLDDVRCSGNESYLWSCPHNGWLSHNCGHSEDAGVICSGGPPRTPIRPRSWPSRFLC 137

Query: 417 ----------IRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGY 466
                     +RL  G  + +GRVEV   G     WG +C D W T +A V CRQLG G+
Sbjct: 138 SPIGPESSLALRLVNGGDRCQGRVEVLYRG----SWGTVCDDSWDTNDANVVCRQLGCGW 193

Query: 467 ANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSE 526
           A        +        +V+  VRC+G E  L  C ++G        G    AGVICS 
Sbjct: 194 ATSAPGNARFGQGSG--PIVLDDVRCSGHESYLWSCPNNGW--LSHNCGHHEDAGVICS- 248

Query: 527 TASDLLLHSALVQE---TAYIEDRPLHMLYCAAEE 558
             S  +      QE    A  +D PL  + CAA++
Sbjct: 249 -GSWAVAGPRRPQEMPGLARAQD-PLFWMMCAAQD 281



 Score =  134 bits (337), Expect = 3e-31
 Identities = 83/229 (36%), Positives = 111/229 (48%), Gaps = 15/229 (6%)

Query: 186 EGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLG--FPSEKRVNAAFYRLLAQRQQHSFGL 243
           +G VEV     W  VCD  W  ++++VVC  LG  +      NA F      +      L
Sbjct: 28  QGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARF-----GQGSGPIVL 82

Query: 244 HGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK--- 300
             V C G E++L  C    + +++   C     A V C  GP       +    +     
Sbjct: 83  DDVRCSGNESYLWSCPHNGWLSHN---CGHSEDAGVICSGGPPRTPIRPRSWPSRFLCSP 139

Query: 301 --PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALS 358
             P+    +RL  G    +GRVEVL   +WGTVCD  WD + A+VVCR+LG G A  A  
Sbjct: 140 IGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPG 199

Query: 359 GARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCN 407
            AR GQG G I L +VRCSG E  LW CP+    + +C H +DAGV C+
Sbjct: 200 NARFGQGSGPIVLDDVRCSGHESYLWSCPNNGWLSHNCGHHEDAGVICS 248



 Score =  107 bits (267), Expect = 4e-23
 Identities = 71/215 (33%), Positives = 102/215 (47%), Gaps = 26/215 (12%)

Query: 55  EGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSC 114
           +GRVE+   G WGT+CDD +    A+++CR+LG   A     +A++G G+G I LD++ C
Sbjct: 28  QGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSGPIVLDDVRC 87

Query: 115 SGTEQSVTECASRGWGNSDCTHDEDAGVIC---------KDQRLPGFSDSNVIEVEHHLQ 165
           SG E  +  C   GW + +C H EDAGVIC         + +  P     + I  E  L 
Sbjct: 88  SGNESYLWSCPHNGWLSHNCGHSEDAGVICSGGPPRTPIRPRSWPSRFLCSPIGPESSLA 147

Query: 166 VEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGML--GFPSEK 223
           +        V  G R     +G VEV     W  VCD  W  ++++VVC  L  G+ +  
Sbjct: 148 LR------LVNGGDR----CQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSA 197

Query: 224 RVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLC 258
             NA F      +      L  V C G E++L  C
Sbjct: 198 PGNARF-----GQGSGPIVLDDVRCSGHESYLWSC 227



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 44/109 (40%), Positives = 65/109 (59%), Gaps = 10/109 (9%)

Query: 55  EGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSC 114
           +GRVE+   G WGT+CDD +    A+++CR+LG   AT    +A++G G+G I LD++ C
Sbjct: 158 QGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 217

Query: 115 SGTEQSVTECASRGWGNSDCTHDEDAGVIC----------KDQRLPGFS 153
           SG E  +  C + GW + +C H EDAGVIC          + Q +PG +
Sbjct: 218 SGHESYLWSCPNNGWLSHNCGHHEDAGVICSGSWAVAGPRRPQEMPGLA 266


>gi|194018748 CD6 molecule [Homo sapiens]
          Length = 668

 Score =  135 bits (340), Expect = 1e-31
 Identities = 109/360 (30%), Positives = 147/360 (40%), Gaps = 63/360 (17%)

Query: 187 GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGV 246
           G VEVRL   W   C   W +  +  VC  LG    +  +             + G   V
Sbjct: 56  GTVEVRLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSV 115

Query: 247 ACVGTEAHLS--LCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGE 304
           A   T A     LCS   +R  +                   +A  S  ++ + +  +  
Sbjct: 116 AANATLAGAPALLCSGAEWRLCEVVE----------------HACRSDGRRARVTCAENR 159

Query: 305 ARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQ 364
           A +RL  G     GRVE+L+   WG+VCD  WDL  A VVCR+LG G A +AL G     
Sbjct: 160 A-LRLVDGGGACAGRVEMLEHGEWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTP 218

Query: 365 GMGAIHLSEVRCSGQELSLWKCPHKNITAED-CSHSQDAGVRCNLPYTGAETRIRLSGGR 423
           G G IH  +V CSG E  LW CP   +  +  C H +DAG  C+          RL+GG 
Sbjct: 219 GRGPIHRDQVNCSGAEAYLWDCP--GLPGQHYCGHKEDAGAVCS-----EHQSWRLTGGA 271

Query: 424 SQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYA-------NHGLQETWY 476
            + EG+VEV   G     W  +C  +W   EA V C+ LG G A        H L    Y
Sbjct: 272 DRCEGQVEVHFRGV----WNTVCDSEWYPSEAKVLCQSLGCGTAVERPKGLPHSLSGRMY 327

Query: 477 WDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSA 536
           +              C G EL+L  C+             RF    +CS++ +  +L SA
Sbjct: 328 YS-------------CNGEELTLSNCS------------WRFNNSNLCSQSLAARVLCSA 362



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 67/214 (31%), Positives = 90/214 (42%), Gaps = 40/214 (18%)

Query: 56  GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCS 115
           GRVE+   GEWG++CDD + L+ AH++CR+LG   A        + PG G I  D ++CS
Sbjct: 172 GRVEMLEHGEWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRGPIHRDQVNCS 231

Query: 116 GTEQSVTECASRGWGNSDCTHDEDAGVICKDQ---RLPGFSDSNVIEVEHHLQVEEVRIR 172
           G E  + +C     G   C H EDAG +C +    RL G +D                  
Sbjct: 232 GAEAYLWDCPGLP-GQHYCGHKEDAGAVCSEHQSWRLTGGADR----------------- 273

Query: 173 PAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRL 232
                        EG VEV     W+ VCD  W    + V+C  LG  +           
Sbjct: 274 ------------CEGQVEVHFRGVWNTVCDSEWYPSEAKVLCQSLGCGTAVERPKGLPHS 321

Query: 233 LAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRAN 266
           L+ R  +S       C G E  LS CS  F  +N
Sbjct: 322 LSGRMYYS-------CNGEELTLSNCSWRFNNSN 348



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 75/264 (28%), Positives = 98/264 (37%), Gaps = 37/264 (14%)

Query: 283 PGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAAS 342
           P P    ++   + +  +P     VRL  G+    G VEV   ++W   C   WD  AA 
Sbjct: 21  PAPPDQLNTSSAESELWEPGERLPVRLTNGSSSCSGTVEVRLEASWEPACGALWDSRAAE 80

Query: 343 VVCRELGFGSAR---------------EALSGARMGQGMGAIHLSEVRCSGQELSLWKCP 387
            VCR LG G A                 A     +           + CSG E  L +  
Sbjct: 81  AVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSVAANATLAGAPALLCSGAEWRLCE-- 138

Query: 388 HKNITAEDC-SHSQDAGVRCNLPYTGAETR-IRLSGGRSQHEGRVEVQIGGPGPLRWGLI 445
              +    C S  + A V C      AE R +RL  G     GRVE+   G     WG +
Sbjct: 139 ---VVEHACRSDGRRARVTC------AENRALRLVDGGGACAGRVEMLEHG----EWGSV 185

Query: 446 CGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHH 505
           C D W   +A V CRQLG G+A   L    +        +    V C+G E  L  C   
Sbjct: 186 CDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRG--PIHRDQVNCSGAEAYLWDCPGL 243

Query: 506 GTHITCKRTGTRFTAGVICSETAS 529
                C   G +  AG +CSE  S
Sbjct: 244 PGQHYC---GHKEDAGAVCSEHQS 264



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 48/161 (29%), Positives = 75/161 (46%), Gaps = 21/161 (13%)

Query: 23  CLGSPSPS-TGPEKKAG---SQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQA 78
           C G P     G ++ AG   S+   +RL G   +  EG+VE+   G W T+CD ++    
Sbjct: 240 CPGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADR-CEGQVEVHFRGVWNTVCDSEWYPSE 298

Query: 79  AHILCRELGFTEAT----GWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDC 134
           A +LC+ LG   A     G  HS      +GR++    SC+G E +++ C+ R   ++ C
Sbjct: 299 AKVLCQSLGCGTAVERPKGLPHSL-----SGRMY---YSCNGEELTLSNCSWRFNNSNLC 350

Query: 135 THDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAV 175
           +    A V+C   R    S  N+   E    V+ V I  +V
Sbjct: 351 SQSLAARVLCSASR----SLHNLSTPEVPASVQTVTIESSV 387


>gi|20357512 macrophage scavenger receptor 1 isoform type 1 [Homo
           sapiens]
          Length = 451

 Score =  109 bits (273), Expect = 8e-24
 Identities = 57/132 (43%), Positives = 75/132 (56%), Gaps = 8/132 (6%)

Query: 285 PVYAA---SSGQKKQQQSKPQGEA-----RVRLKGGAHPGEGRVEVLKASTWGTVCDRKW 336
           P YA    +SG K Q+  K  G       +VRL GG+ P EGRVE+L +  WGT+CD +W
Sbjct: 320 PGYAGRPGNSGPKGQKGEKGSGNTLTPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRW 379

Query: 337 DLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDC 396
           ++    VVCR LG+   +     A  GQG G I L+EV C G+E S+ +C  +      C
Sbjct: 380 EVRVGQVVCRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCFGRESSIEECKIRQWGTRAC 439

Query: 397 SHSQDAGVRCNL 408
           SHS+DAGV C L
Sbjct: 440 SHSEDAGVTCTL 451



 Score =  108 bits (269), Expect = 2e-23
 Identities = 50/122 (40%), Positives = 71/122 (58%), Gaps = 7/122 (5%)

Query: 30  STGPEKKAGSQGLRFRLAGFPRK-------PYEGRVEIQRAGEWGTICDDDFTLQAAHIL 82
           ++GP+ + G +G    L  F +        P+EGRVEI  +G+WGTICDD + ++   ++
Sbjct: 328 NSGPKGQKGEKGSGNTLTPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVV 387

Query: 83  CRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGV 142
           CR LG+        +A +G GTG IWL+ + C G E S+ EC  R WG   C+H EDAGV
Sbjct: 388 CRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGV 447

Query: 143 IC 144
            C
Sbjct: 448 TC 449



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 37/116 (31%), Positives = 54/116 (46%), Gaps = 18/116 (15%)

Query: 415 TRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQET 474
           T++RL GG   HEGRVE+   G    +WG IC D W      V CR LG       + + 
Sbjct: 348 TKVRLVGGSGPHEGRVEILHSG----QWGTICDDRWEVRVGQVVCRSLGYP-GVQAVHKA 402

Query: 475 WYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRF-----TAGVICS 525
            ++  G    + ++ V C G E S+++C         ++ GTR       AGV C+
Sbjct: 403 AHFGQGT-GPIWLNEVFCFGRESSIEEC-------KIRQWGTRACSHSEDAGVTCT 450



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 28/96 (29%), Positives = 40/96 (41%), Gaps = 6/96 (6%)

Query: 186 EGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHG 245
           EG VE+     W  +CD  W      VVC  LG+P  + V+ A +     +      L+ 
Sbjct: 360 EGRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAH---FGQGTGPIWLNE 416

Query: 246 VACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSC 281
           V C G E+ +  C +   R   T  C     A V+C
Sbjct: 417 VFCFGRESSIEECKI---RQWGTRACSHSEDAGVTC 449


>gi|5803080 macrophage receptor with collagenous structure [Homo
           sapiens]
          Length = 520

 Score =  101 bits (251), Expect = 3e-21
 Identities = 46/113 (40%), Positives = 66/113 (58%), Gaps = 6/113 (5%)

Query: 32  GPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEA 91
           G + + G   +  R+ G   +   GR E+  +G WGTICDD++    A + CR LG+++ 
Sbjct: 412 GEKGERGENSVSVRIVGSSNR---GRAEVYYSGTWGTICDDEWQNSDAIVFCRMLGYSKG 468

Query: 92  TGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVIC 144
                  K G GTG+IWLDN+ C GTE ++  C    WG+ DC+H+EDAGV C
Sbjct: 469 RALY---KVGAGTGQIWLDNVQCRGTESTLWSCTKNSWGHHDCSHEEDAGVEC 518



 Score = 89.7 bits (221), Expect = 9e-18
 Identities = 44/121 (36%), Positives = 64/121 (52%), Gaps = 5/121 (4%)

Query: 288 AASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRE 347
           +   G K ++  + +    VR+ G ++   GR EV  + TWGT+CD +W    A V CR 
Sbjct: 405 SGEQGVKGEKGERGENSVSVRIVGSSN--RGRAEVYYSGTWGTICDDEWQNSDAIVFCRM 462

Query: 348 LGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCN 407
           LG+   R      ++G G G I L  V+C G E +LW C   +    DCSH +DAGV C+
Sbjct: 463 LGYSKGRALY---KVGAGTGQIWLDNVQCRGTESTLWSCTKNSWGHHDCSHEEDAGVECS 519

Query: 408 L 408
           +
Sbjct: 520 V 520



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 35/110 (31%), Positives = 48/110 (43%), Gaps = 15/110 (13%)

Query: 417 IRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWY 476
           +R+ G  S + GR EV   G     WG IC D+W   +A+V CR LG     +      Y
Sbjct: 424 VRIVG--SSNRGRAEVYYSGT----WGTICDDEWQNSDAIVFCRMLG-----YSKGRALY 472

Query: 477 WDSGNITEVVMSGVRCTGTELSLDQCAHHG-THITCKRTGTRFTAGVICS 525
                  ++ +  V+C GTE +L  C  +   H  C        AGV CS
Sbjct: 473 KVGAGTGQIWLDNVQCRGTESTLWSCTKNSWGHHDCSH---EEDAGVECS 519



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 29/95 (30%), Positives = 40/95 (42%), Gaps = 9/95 (9%)

Query: 187 GLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGV 246
           G  EV     W  +CD  W   ++ V C MLG+   +    A Y++ A   Q    L  V
Sbjct: 433 GRAEVYYSGTWGTICDDEWQNSDAIVFCRMLGYSKGR----ALYKVGAGTGQ--IWLDNV 486

Query: 247 ACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSC 281
            C GTE+ L  C+   +  +D   C     A V C
Sbjct: 487 QCRGTESTLWSCTKNSWGHHD---CSHEEDAGVEC 518


>gi|5031863 galectin 3 binding protein [Homo sapiens]
          Length = 585

 Score =  100 bits (250), Expect = 4e-21
 Identities = 51/114 (44%), Positives = 71/114 (62%), Gaps = 4/114 (3%)

Query: 37  AGSQGLR---FRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATG 93
           AG+QG+     RLA       +GRVEI   G+WGT+CD+ + L  A ++CR LGF  AT 
Sbjct: 14  AGTQGVNDGDMRLAD-GGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQ 72

Query: 94  WTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQ 147
               A +G G+G I LD + C+GTE S+ +C S GW  S+C H+ DAGV+C ++
Sbjct: 73  ALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTNE 126



 Score =  100 bits (250), Expect = 4e-21
 Identities = 50/100 (50%), Positives = 59/100 (59%)

Query: 307 VRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGM 366
           +RL  G    +GRVE+     WGTVCD  WDL  ASVVCR LGF +A +AL  A  GQG 
Sbjct: 24  MRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGS 83

Query: 367 GAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRC 406
           G I L EV+C+G E SL  C        +C H +DAGV C
Sbjct: 84  GPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVC 123



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 11/115 (9%)

Query: 417 IRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWY 476
           +RL+ G + ++GRVE+   G    +WG +C + W   +A V CR LG   A   L    +
Sbjct: 24  MRLADGGATNQGRVEIFYRG----QWGTVCDNLWDLTDASVVCRALGFENATQALGRAAF 79

Query: 477 WDSGNITEVVMSGVRCTGTELSLDQCAHHG-THITCKRTGTRFTAGVIC-SETAS 529
                   +++  V+CTGTE SL  C   G     C+       AGV+C +ET S
Sbjct: 80  GQGSG--PIMLDEVQCTGTEASLADCKSLGWLKSNCRH---ERDAGVVCTNETRS 129



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/82 (34%), Positives = 38/82 (46%), Gaps = 4/82 (4%)

Query: 186 EGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHG 245
           +G VE+     W  VCD  W   ++ VVC  LGF   +    A  R    +      L  
Sbjct: 34  QGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGF---ENATQALGRAAFGQGSGPIMLDE 90

Query: 246 VACVGTEAHLSLC-SLEFYRAN 266
           V C GTEA L+ C SL + ++N
Sbjct: 91  VQCTGTEASLADCKSLGWLKSN 112


>gi|47271477 scavenger receptor class A, member 5 [Homo sapiens]
          Length = 495

 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 40/92 (43%), Positives = 60/92 (65%)

Query: 53  PYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNL 112
           P+EGRVE+     WGT+CDD +  +   ++CR LGF        +A++G GTGRIW+D++
Sbjct: 401 PHEGRVEVYHDRRWGTVCDDGWDKKDGDVVCRMLGFRGVEEVYRTARFGQGTGRIWMDDV 460

Query: 113 SCSGTEQSVTECASRGWGNSDCTHDEDAGVIC 144
           +C GTE+++  C+   WG ++C H EDA V C
Sbjct: 461 ACKGTEETIFRCSFSKWGVTNCGHAEDASVTC 492



 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 47/116 (40%), Positives = 60/116 (51%)

Query: 292 GQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFG 351
           G +    S  +    +RL  G+ P EGRVEV     WGTVCD  WD     VVCR LGF 
Sbjct: 378 GDRAGDASGVEAPMMIRLVNGSGPHEGRVEVYHDRRWGTVCDDGWDKKDGDVVCRMLGFR 437

Query: 352 SAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCN 407
              E    AR GQG G I + +V C G E ++++C        +C H++DA V CN
Sbjct: 438 GVEEVYRTARFGQGTGRIWMDDVACKGTEETIFRCSFSKWGVTNCGHAEDASVTCN 493



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 37/115 (32%), Positives = 49/115 (42%), Gaps = 12/115 (10%)

Query: 413 AETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQ 472
           A   IRL  G   HEGRVEV        RWG +C D W   +  V CR LG      G++
Sbjct: 389 APMMIRLVNGSGPHEGRVEVY----HDRRWGTVCDDGWDKKDGDVVCRMLGF----RGVE 440

Query: 473 ETWYWD--SGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICS 525
           E +           + M  V C GTE ++ +C+     +T    G    A V C+
Sbjct: 441 EVYRTARFGQGTGRIWMDDVACKGTEETIFRCSFSKWGVT--NCGHAEDASVTCN 493



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 34/97 (35%), Positives = 40/97 (41%), Gaps = 8/97 (8%)

Query: 186 EGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQ-QHSFGLH 244
           EG VEV     W  VCD GW   +  VVC MLGF   + V    YR     Q      + 
Sbjct: 403 EGRVEVYHDRRWGTVCDDGWDKKDGDVVCRMLGFRGVEEV----YRTARFGQGTGRIWMD 458

Query: 245 GVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSC 281
            VAC GTE  +  CS   +       C     A V+C
Sbjct: 459 DVACKGTEETIFRCSFSKW---GVTNCGHAEDASVTC 492


>gi|187936955 HHIP-like protein 1 isoform a [Homo sapiens]
          Length = 782

 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 55/150 (36%), Positives = 74/150 (49%), Gaps = 6/150 (4%)

Query: 264 RANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQ-----GEARVRLKGGAHPGEG 318
           R   TA  P   P        P      G+++ + +        GE R+    G   G G
Sbjct: 627 RGRPTAAPPAPTPRPARPTQQPGSRRGGGRRRGRLNSASRAFRDGEVRLVRPAGLSSGSG 686

Query: 319 RVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMG-AIHLSEVRCS 377
           RVEV     WGTVCD  W++  A+VVCR+LGF  A  A+  A  GQG    I L +VRC+
Sbjct: 687 RVEVFVGGRWGTVCDDSWNISGAAVVCRQLGFAYAVRAVKRAEFGQGGSLPILLDDVRCA 746

Query: 378 GQELSLWKCPHKNITAEDCSHSQDAGVRCN 407
           G E +L +C H  +   +C H +DAGV C+
Sbjct: 747 GWERNLLECQHNGVGTHNCEHDEDAGVVCS 776



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 41/93 (44%), Positives = 58/93 (62%), Gaps = 1/93 (1%)

Query: 56  GRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTG-RIWLDNLSC 114
           GRVE+   G WGT+CDD + +  A ++CR+LGF  A      A++G G    I LD++ C
Sbjct: 686 GRVEVFVGGRWGTVCDDSWNISGAAVVCRQLGFAYAVRAVKRAEFGQGGSLPILLDDVRC 745

Query: 115 SGTEQSVTECASRGWGNSDCTHDEDAGVICKDQ 147
           +G E+++ EC   G G  +C HDEDAGV+C  Q
Sbjct: 746 AGWERNLLECQHNGVGTHNCEHDEDAGVVCSHQ 778



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 46/124 (37%), Positives = 63/124 (50%), Gaps = 11/124 (8%)

Query: 410 YTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANH 469
           +   E R+    G S   GRVEV +GG    RWG +C D W    A V CRQLG  YA  
Sbjct: 668 FRDGEVRLVRPAGLSSGSGRVEVFVGG----RWGTVCDDSWNISGAAVVCRQLGFAYAVR 723

Query: 470 GLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHH--GTHITCKRTGTRFTAGVICSET 527
            ++   +   G++  +++  VRC G E +L +C H+  GTH  C+       AGV+CS  
Sbjct: 724 AVKRAEFGQGGSL-PILLDDVRCAGWERNLLECQHNGVGTH-NCEHDE---DAGVVCSHQ 778

Query: 528 ASDL 531
             DL
Sbjct: 779 NPDL 782



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 37/115 (32%), Positives = 43/115 (37%), Gaps = 12/115 (10%)

Query: 168 EVR-IRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVN 226
           EVR +RPA       L    G VEV +   W  VCD  W+   + VVC  LGF     V 
Sbjct: 672 EVRLVRPA------GLSSGSGRVEVFVGGRWGTVCDDSWNISGAAVVCRQLGF--AYAVR 723

Query: 227 AAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSC 281
           A       Q       L  V C G E +L  C    +    T  C     A V C
Sbjct: 724 AVKRAEFGQGGSLPILLDDVRCAGWERNLLECQ---HNGVGTHNCEHDEDAGVVC 775


>gi|20357515 macrophage scavenger receptor 1 isoform type 3 [Homo
           sapiens]
          Length = 388

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 22/41 (53%), Positives = 26/41 (63%)

Query: 104 TGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVIC 144
           TG IWL+ + C G E S+ EC  R WG   C+H EDAGV C
Sbjct: 346 TGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTC 386



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 20/42 (47%), Positives = 26/42 (61%)

Query: 367 GAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNL 408
           G I L+EV C G+E S+ +C  +      CSHS+DAGV C L
Sbjct: 347 GPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTCTL 388


>gi|166197668 CD5 molecule [Homo sapiens]
          Length = 495

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 75/300 (25%), Positives = 111/300 (37%), Gaps = 36/300 (12%)

Query: 186 EGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHG 245
           +G +EV L DGW  VC + W   +             +R+N      L            
Sbjct: 45  QGQLEVYLKDGWHMVCSQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSS 104

Query: 246 VACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCV-PGPVYAASSGQKKQQQSKPQGE 304
           + C G     S CS   +  ND     G     ++C+ P      ++        +P   
Sbjct: 105 IICYGQLGSFSNCS---HSRNDMCHSLG-----LTCLEPQKTTPPTTRPPPTTTPEPTAP 156

Query: 305 ARVRL---KGGAHPGEGRVEVLKASTWGTVC----DRKWDLHAASVVCRELGFGSAREAL 357
            R++L    GG H   G VE    S  GT+     D+  DL   + +C  L  GS  + L
Sbjct: 157 PRLQLVAQSGGQHCA-GVVEFYSGSLGGTISYEAQDKTQDLE--NFLCNNLQCGSFLKHL 213

Query: 358 SGARMGQGMGAIHLSEVRCSGQELSL-WKCPHKNITA-EDCSHS---QDAGVRCNLPYTG 412
                G+        E R   Q L + WK  + + T+ E C      Q +G    L  +G
Sbjct: 214 PETEAGRAQDP---GEPR-EHQPLPIQWKIQNSSCTSLEHCFRKIKPQKSGRVLALLCSG 269

Query: 413 AETRI--RLSGGRSQHEGRVEVQIGGPGPLRWGLICGDD--WGTLEAMVACRQLGLGYAN 468
            + ++  RL GG S  EG VEV+ G     +W  +C       +L     CR+   G  N
Sbjct: 270 FQPKVQSRLVGGSSICEGTVEVRQGA----QWAALCDSSSARSSLRWEEVCREQQCGSVN 325



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 30/108 (27%), Positives = 45/108 (41%), Gaps = 23/108 (21%)

Query: 302 QGEARVRLKGGAHPGEGRVEVLKASTWGTVCDR-------KWDLHAASVVCRELGFGSA- 353
           Q + + RL GG+   EG VEV + + W  +CD        +W+      VCRE   GS  
Sbjct: 271 QPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWE-----EVCREQQCGSVN 325

Query: 354 --REALSGARMGQGMGAIHLSEVRCSGQELSLWK----CPHKNITAED 395
             R   +G    +G+   H    +C      LW+    C    +T +D
Sbjct: 326 SYRVLDAGDPTSRGLFCPHQKLSQCH----ELWERNSYCKKVFVTCQD 369


>gi|119392081 complement factor I preproprotein [Homo sapiens]
          Length = 583

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 3/88 (3%)

Query: 302 QGEARVRLKGGAHPGEGRVEVLKASTWGT--VCDRKWDLHAASVVCRELGFGSAREALSG 359
           +G+  V LK G    EG VEV       T  +C   W +  A+V C +LGF    +    
Sbjct: 109 EGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRR 168

Query: 360 ARMGQ-GMGAIHLSEVRCSGQELSLWKC 386
            ++    + +     V C G E SL +C
Sbjct: 169 FKLSDLSINSTECLHVHCRGLETSLAEC 196



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 34/115 (29%), Positives = 46/115 (40%), Gaps = 9/115 (7%)

Query: 417 IRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWY 476
           + L  G +  EG VEV++       +  IC   W   EA VAC  LG        Q  + 
Sbjct: 114 VSLKHGNTDSEGIVEVKLVDQDKTMF--ICKSSWSMREANVACLDLGF-QQGADTQRRFK 170

Query: 477 WDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRT-GTRFTAGVICSETASD 530
               +I       V C G E SL +C       T +RT G +  A V+C    +D
Sbjct: 171 LSDLSINSTECLHVHCRGLETSLAECT-----FTKRRTMGYQDFADVVCYTQKAD 220



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 24/77 (31%), Positives = 34/77 (44%), Gaps = 4/77 (5%)

Query: 185 TEGLVEVRLPDGWSQ--VCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFG 242
           +EG+VEV+L D      +C   WS   ++V C  LGF         F   L+    +S  
Sbjct: 123 SEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRF--KLSDLSINSTE 180

Query: 243 LHGVACVGTEAHLSLCS 259
              V C G E  L+ C+
Sbjct: 181 CLHVHCRGLETSLAECT 197



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 25/104 (24%), Positives = 44/104 (42%), Gaps = 19/104 (18%)

Query: 55  EGRVEIQRAGEWGT--ICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNL 112
           EG VE++   +  T  IC   ++++ A++ C +LGF +               R  L +L
Sbjct: 124 EGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQR---------RFKLSDL 174

Query: 113 SCSGTEQSVTECASRGWGNSDCT--------HDEDAGVICKDQR 148
           S + TE     C       ++CT        + + A V+C  Q+
Sbjct: 175 SINSTECLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQK 218


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score = 36.2 bits (82), Expect = 0.12
 Identities = 14/33 (42%), Positives = 21/33 (63%)

Query: 320 VEVLKASTWGTVCDRKWDLHAASVVCRELGFGS 352
           ++V  A++W T+C   W  H A+V C +LGF S
Sbjct: 117 LQVFTAASWKTMCSDDWKGHYANVACAQLGFPS 149



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 12/34 (35%), Positives = 18/34 (52%)

Query: 188 LVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPS 221
           +++V     W  +C   W  H ++V C  LGFPS
Sbjct: 116 VLQVFTAASWKTMCSDDWKGHYANVACAQLGFPS 149



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 25/79 (31%), Positives = 31/79 (39%), Gaps = 14/79 (17%)

Query: 395 DCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVE---VQIGGPGPL-------RWGL 444
           DCS       RC   +   E   R  G     +G  E   V++GG   +        W  
Sbjct: 72  DCSGKY----RCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKT 127

Query: 445 ICGDDWGTLEAMVACRQLG 463
           +C DDW    A VAC QLG
Sbjct: 128 MCSDDWKGHYANVACAQLG 146



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 11/31 (35%), Positives = 19/31 (61%)

Query: 58  VEIQRAGEWGTICDDDFTLQAAHILCRELGF 88
           +++  A  W T+C DD+    A++ C +LGF
Sbjct: 117 LQVFTAASWKTMCSDDWKGHYANVACAQLGF 147


>gi|14602457 transmembrane protease, serine 3 isoform 3 [Homo
           sapiens]
          Length = 344

 Score = 36.2 bits (82), Expect = 0.12
 Identities = 14/33 (42%), Positives = 21/33 (63%)

Query: 320 VEVLKASTWGTVCDRKWDLHAASVVCRELGFGS 352
           ++V  A++W T+C   W  H A+V C +LGF S
Sbjct: 117 LQVFTAASWKTMCSDDWKGHYANVACAQLGFPS 149



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 12/34 (35%), Positives = 18/34 (52%)

Query: 188 LVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPS 221
           +++V     W  +C   W  H ++V C  LGFPS
Sbjct: 116 VLQVFTAASWKTMCSDDWKGHYANVACAQLGFPS 149



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 25/79 (31%), Positives = 31/79 (39%), Gaps = 14/79 (17%)

Query: 395 DCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVE---VQIGGPGPL-------RWGL 444
           DCS       RC   +   E   R  G     +G  E   V++GG   +        W  
Sbjct: 72  DCSGKY----RCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKT 127

Query: 445 ICGDDWGTLEAMVACRQLG 463
           +C DDW    A VAC QLG
Sbjct: 128 MCSDDWKGHYANVACAQLG 146



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 11/31 (35%), Positives = 19/31 (61%)

Query: 58  VEIQRAGEWGTICDDDFTLQAAHILCRELGF 88
           +++  A  W T+C DD+    A++ C +LGF
Sbjct: 117 LQVFTAASWKTMCSDDWKGHYANVACAQLGF 147


>gi|239752583 PREDICTED: hypothetical protein XP_002348171 [Homo
           sapiens]
          Length = 146

 Score = 34.7 bits (78), Expect = 0.34
 Identities = 12/41 (29%), Positives = 21/41 (51%)

Query: 83  CRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTE 123
           C   GFT ++ W H  +  PG G +W+  ++  G+  S  +
Sbjct: 41  CAASGFTFSSYWMHWVRQAPGKGLVWVSRINSDGSSTSYAD 81


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.452 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,958,781
Number of Sequences: 37866
Number of extensions: 1702229
Number of successful extensions: 4540
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 3796
Number of HSP's gapped (non-prelim): 215
length of query: 753
length of database: 18,247,518
effective HSP length: 110
effective length of query: 643
effective length of database: 14,082,258
effective search space: 9054891894
effective search space used: 9054891894
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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