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Search of human proteins with 9966877
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9966877 golgi associated PDZ and coiled-coil motif
containing isoform a [Homo sapiens]
(462 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9966877 golgi associated PDZ and coiled-coil motif containing... 924 0.0
gi|62868213 golgi associated PDZ and coiled-coil motif containin... 901 0.0
gi|5803177 basic beta 2 syntrophin [Homo sapiens] 85 1e-16
gi|11321640 basic beta 1 syntrophin [Homo sapiens] 83 5e-16
gi|4507137 acidic alpha 1 syntrophin [Homo sapiens] 78 2e-14
gi|9507165 syntrophin, gamma 2 [Homo sapiens] 75 2e-13
gi|8922944 lin-7 homolog C [Homo sapiens] 74 2e-13
gi|4759306 lin-7 homolog A [Homo sapiens] 74 2e-13
gi|11545920 lin-7 homolog B [Homo sapiens] 74 3e-13
gi|9507163 syntrophin, gamma 1 [Homo sapiens] 70 5e-12
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 65 2e-10
gi|112382257 InaD-like [Homo sapiens] 63 6e-10
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 60 5e-09
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 59 9e-09
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 59 9e-09
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 59 1e-08
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 57 3e-08
gi|41281808 harmonin isoform b3 [Homo sapiens] 56 8e-08
gi|71480164 harmonin isoform a [Homo sapiens] 56 8e-08
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 55 1e-07
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 55 1e-07
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 55 1e-07
gi|45827729 scribble isoform b [Homo sapiens] 55 1e-07
gi|45827731 scribble isoform a [Homo sapiens] 55 1e-07
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 55 1e-07
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 55 1e-07
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 55 1e-07
gi|87196343 PDZ domain containing 2 [Homo sapiens] 55 1e-07
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 55 2e-07
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 55 2e-07
>gi|9966877 golgi associated PDZ and coiled-coil motif containing
isoform a [Homo sapiens]
Length = 462
Score = 924 bits (2387), Expect = 0.0
Identities = 462/462 (100%), Positives = 462/462 (100%)
Query: 1 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA 60
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
Sbjct: 1 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA 60
Query: 61 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH 120
DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
Sbjct: 61 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH 120
Query: 121 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK 180
DQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK
Sbjct: 121 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK 180
Query: 181 LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL 240
LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL
Sbjct: 181 LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL 240
Query: 241 EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG 300
EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG
Sbjct: 241 EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG 300
Query: 301 ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR 360
ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
Sbjct: 301 ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR 360
Query: 361 GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG 420
GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG
Sbjct: 361 GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG 420
Query: 421 FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY 462
FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
Sbjct: 421 FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY 462
>gi|62868213 golgi associated PDZ and coiled-coil motif containing
isoform b [Homo sapiens]
Length = 454
Score = 901 bits (2329), Expect = 0.0
Identities = 454/462 (98%), Positives = 454/462 (98%), Gaps = 8/462 (1%)
Query: 1 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA 60
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
Sbjct: 1 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA 60
Query: 61 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH 120
DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
Sbjct: 61 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH 120
Query: 121 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK 180
DQLLQLHSIQLQLHAKTGQSADSGTIKAKL ERELEANKKEKMKEAQLEAEVK
Sbjct: 121 DQLLQLHSIQLQLHAKTGQSADSGTIKAKL--------ERELEANKKEKMKEAQLEAEVK 172
Query: 181 LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL 240
LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL
Sbjct: 173 LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL 232
Query: 241 EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG 300
EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG
Sbjct: 233 EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG 292
Query: 301 ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR 360
ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
Sbjct: 293 ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR 352
Query: 361 GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG 420
GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG
Sbjct: 353 GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG 412
Query: 421 FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY 462
FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
Sbjct: 413 FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY 454
>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
Length = 540
Score = 85.1 bits (209), Expect = 1e-16
Identities = 43/103 (41%), Positives = 66/103 (64%)
Query: 268 APPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRC 327
+PP + ++ P+R+V ++K++ GLGISI GG+E+ +PILIS+I PG AD+
Sbjct: 95 SPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQS 154
Query: 328 GGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYV 370
L +GDAIL+VNG +LR H +AV L + E+ EV ++
Sbjct: 155 RALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFI 197
>gi|11321640 basic beta 1 syntrophin [Homo sapiens]
Length = 538
Score = 83.2 bits (204), Expect = 5e-16
Identities = 45/84 (53%), Positives = 58/84 (69%)
Query: 287 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346
R V +LK++ GLGISI GGKE+ +PILIS+I G AD+ L+VGDAIL+VNG +LRD
Sbjct: 111 RGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRD 170
Query: 347 TKHKEAVTILSQQRGEIEFEVVYV 370
H EAV L + E+ EV Y+
Sbjct: 171 ATHDEAVQALKRAGKEVLLEVKYM 194
>gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
Length = 505
Score = 77.8 bits (190), Expect = 2e-14
Identities = 42/84 (50%), Positives = 55/84 (65%)
Query: 287 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346
R+V + K D GLGISI GG+E+ +PILIS+I G AD+ L VGDAIL+VNG +L
Sbjct: 86 RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
Query: 347 TKHKEAVTILSQQRGEIEFEVVYV 370
H EAV +L + E+ EV Y+
Sbjct: 146 ATHDEAVQVLKKTGKEVVLEVKYM 169
>gi|9507165 syntrophin, gamma 2 [Homo sapiens]
Length = 539
Score = 74.7 bits (182), Expect = 2e-13
Identities = 37/84 (44%), Positives = 53/84 (63%)
Query: 287 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346
R V L ++ GLG+SI GG EH VP++IS+I Q AD+ G L VGDA+L VNG+++ +
Sbjct: 72 RTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVEN 131
Query: 347 TKHKEAVTILSQQRGEIEFEVVYV 370
H+E V +L E+ V Y+
Sbjct: 132 ATHEEVVHLLRNAGDEVTITVEYL 155
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 74.3 bits (181), Expect = 2e-13
Identities = 39/95 (41%), Positives = 57/95 (60%)
Query: 288 KVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 347
+V+ L + EGLG +I GGKE PI IS I PG ADR GGL GD +L+VNGV++
Sbjct: 92 RVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151
Query: 348 KHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVE 382
H++AV +L +G+++ V Y ++ + E
Sbjct: 152 HHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFE 186
>gi|4759306 lin-7 homolog A [Homo sapiens]
Length = 233
Score = 74.3 bits (181), Expect = 2e-13
Identities = 57/186 (30%), Positives = 91/186 (48%), Gaps = 22/186 (11%)
Query: 210 LDKELAGRVQQIQLLGRDMKGPAH--DKLWNQLEAE-------IHLHRHKTV-IRAC--- 256
LD+++A ++ ++ L + P H L L++E ++ + H+T+ + C
Sbjct: 25 LDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEF 84
Query: 257 RGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILIS 316
R R K + A S+G R V L K D EGLG ++ GGKE PI IS
Sbjct: 85 RARATAKATVAA--------FAASEGHSHPRVVELPKTD-EGLGFNVMGGKEQNSPIYIS 135
Query: 317 EIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDS 376
I PG A+R GGL GD +L+VNGV++ H++AV +L + ++ V Y ++
Sbjct: 136 RIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEE 195
Query: 377 DDENVE 382
+ E
Sbjct: 196 MEARFE 201
>gi|11545920 lin-7 homolog B [Homo sapiens]
Length = 207
Score = 73.9 bits (180), Expect = 3e-13
Identities = 42/90 (46%), Positives = 56/90 (62%), Gaps = 1/90 (1%)
Query: 280 SQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAV 339
S+G R V L K D EGLG +I GGKE PI IS + PG ADR GGL GD +L+V
Sbjct: 85 SEGHAHPRVVELPKTD-EGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSV 143
Query: 340 NGVNLRDTKHKEAVTILSQQRGEIEFEVVY 369
NGV++ +H++AV +L +G ++ V Y
Sbjct: 144 NGVSVEGEQHEKAVELLKAAQGSVKLVVRY 173
>gi|9507163 syntrophin, gamma 1 [Homo sapiens]
Length = 517
Score = 69.7 bits (169), Expect = 5e-12
Identities = 32/84 (38%), Positives = 52/84 (61%)
Query: 287 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346
R V + ++ G G+SI GG EH +P+++S+I Q A+ G L +GDAIL +NG+N+R
Sbjct: 56 RTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRK 115
Query: 347 TKHKEAVTILSQQRGEIEFEVVYV 370
+H+E V +L E+ V ++
Sbjct: 116 CRHEEVVQVLRNAGEEVTLTVSFL 139
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 64.7 bits (156), Expect = 2e-10
Identities = 39/78 (50%), Positives = 47/78 (60%), Gaps = 2/78 (2%)
Query: 280 SQGVGPIRKVLLLK-EDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILA 338
S G G +R V L + + HEGLG SI GG EHGV I +S + PG A++ GL VGD IL
Sbjct: 132 SAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEK-EGLRVGDQILR 190
Query: 339 VNGVNLRDTKHKEAVTIL 356
VN +L H EAV L
Sbjct: 191 VNDKSLARVTHAEAVKAL 208
Score = 58.5 bits (140), Expect = 1e-08
Identities = 37/90 (41%), Positives = 51/90 (56%), Gaps = 2/90 (2%)
Query: 271 GHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGL 330
G + +L QG G +KV L+ D LG++I GG E+G+ I I+ + PG A+ GL
Sbjct: 263 GDRRSTLHLLQG-GDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEG-SGL 320
Query: 331 HVGDAILAVNGVNLRDTKHKEAVTILSQQR 360
VGD IL VNG + + H EAV +L R
Sbjct: 321 KVGDQILEVNGRSFLNILHDEAVRLLKSSR 350
Score = 50.1 bits (118), Expect = 4e-06
Identities = 32/86 (37%), Positives = 45/86 (52%), Gaps = 2/86 (2%)
Query: 275 DSLKKSQGV-GPIRKVLLLKEDHEGLGISITGGKEHGVPI-LISEIHPGQPADRCGGLHV 332
D K G+ P ++ +K+ LGI+I GG P+ I I G A CG L V
Sbjct: 801 DGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKV 860
Query: 333 GDAILAVNGVNLRDTKHKEAVTILSQ 358
G IL VNG+ LR +H+EA I+++
Sbjct: 861 GHVILEVNGLTLRGKEHREAARIIAE 886
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 62.8 bits (151), Expect = 6e-10
Identities = 38/95 (40%), Positives = 57/95 (60%), Gaps = 2/95 (2%)
Query: 289 VLLLKEDHEGLGISITGGKEHGV-PILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 347
++ + + GLG+SI GGK+ + I+I E++ A R G L GD IL VNGV+LR++
Sbjct: 1437 IIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNS 1496
Query: 348 KHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVE 382
H+EA+T L Q ++ VVY D+EN+E
Sbjct: 1497 SHEEAITALRQTPQKVRL-VVYRDEAHYRDEENLE 1530
Score = 55.1 bits (131), Expect = 1e-07
Identities = 52/174 (29%), Positives = 84/174 (48%), Gaps = 23/174 (13%)
Query: 194 AVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVI 253
A++ EVY AA+ D L Q +++ G D++ +H+ EA L + +
Sbjct: 1461 AIVIHEVYEEGAAAR--DGRLWAGDQILEVNGVDLRNSSHE------EAITALRQTPQKV 1512
Query: 254 RACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPI 313
R R++ D+++L+ I V L K+ GLG+SI G K +G +
Sbjct: 1513 RLVVYRDEAHY-------RDEENLE-------IFPVDLQKKAGRGLGLSIVG-KRNGSGV 1557
Query: 314 LISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEV 367
IS+I G AD G L GD IL+VNG ++R+ + TIL +G ++ E+
Sbjct: 1558 FISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI 1611
Score = 50.4 bits (119), Expect = 3e-06
Identities = 32/93 (34%), Positives = 45/93 (48%), Gaps = 9/93 (9%)
Query: 284 GPIRKVLLLKEDHEGLGISITGGK---------EHGVPILISEIHPGQPADRCGGLHVGD 334
GP R V + +E + LGISI GG+ E I I ++ PA + L GD
Sbjct: 1064 GPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
Query: 335 AILAVNGVNLRDTKHKEAVTILSQQRGEIEFEV 367
IL V+GV+L++ H EAV + + F V
Sbjct: 1124 KILEVSGVDLQNASHSEAVEAIKNAGNPVVFIV 1156
Score = 47.4 bits (111), Expect = 3e-05
Identities = 30/85 (35%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Query: 287 RKVLLLKEDHEGLGISITGGKEH---GVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 343
R V + +E + LGISI GG+ +P+ I+ I A R L VGD I+++NG
Sbjct: 1675 RTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQP 1734
Query: 344 LRDTKHKEAVTILSQQRGEIEFEVV 368
L H + V +L G I +VV
Sbjct: 1735 LDGLSHADVVNLLKNAYGRIILQVV 1759
Score = 46.6 bits (109), Expect = 5e-05
Identities = 28/73 (38%), Positives = 39/73 (53%), Gaps = 3/73 (4%)
Query: 284 GPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 343
G + +V L+ D GLG I GGK GV ++ I PG ADR G L GD IL + G N
Sbjct: 244 GHVEEVELIN-DGSGLGFGIVGGKTSGV--VVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
Query: 344 LRDTKHKEAVTIL 356
++ ++ +L
Sbjct: 301 VQGMTSEQVAQVL 313
Score = 43.5 bits (101), Expect = 4e-04
Identities = 22/77 (28%), Positives = 41/77 (53%), Gaps = 1/77 (1%)
Query: 289 VLLLKEDHEGLGISITGGKEHG-VPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 347
++ L++D GLG+S+ G K+ + I + I+P PA G + +GD +L +N L
Sbjct: 1239 IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGR 1298
Query: 348 KHKEAVTILSQQRGEIE 364
H+ A I+ +++
Sbjct: 1299 SHQNASAIIKTAPSKVK 1315
Score = 40.4 bits (93), Expect = 0.003
Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 298 GLGISITGGKEHG---VPILISEIHPGQPADRCGGLHVGDAILAVNGVNL-RDTKHKEAV 353
GLG S+ + V I + ++ PG ADR L D ILA+N L ++ H++A+
Sbjct: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
Query: 354 TILSQQRGEIEFEV 367
+L Q G + V
Sbjct: 204 ALLQQTTGSLRLIV 217
Score = 40.4 bits (93), Expect = 0.003
Identities = 26/73 (35%), Positives = 39/73 (53%), Gaps = 5/73 (6%)
Query: 289 VLLLKEDHEGLGISITG--GKEH---GVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 343
V L+++D + LGI I G G H I + I PG A G + V D I+AV+GVN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 344 LRDTKHKEAVTIL 356
++ + + V +L
Sbjct: 426 IQGFANHDVVEVL 438
Score = 37.0 bits (84), Expect = 0.038
Identities = 28/76 (36%), Positives = 41/76 (53%), Gaps = 4/76 (5%)
Query: 285 PIRKVLLLKEDHEGLGISITGGKEHGVP----ILISEIHPGQPADRCGGLHVGDAILAVN 340
P K++ L +D +GLG SI ++ P I+I + A+R GGL GD +++VN
Sbjct: 682 PEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
Query: 341 GVNLRDTKHKEAVTIL 356
L +T EAV IL
Sbjct: 742 EYCLDNTSLAEAVEIL 757
Score = 33.1 bits (74), Expect = 0.55
Identities = 18/44 (40%), Positives = 23/44 (52%)
Query: 315 ISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQ 358
IS I G P D G L D +L VNG+ L +EAV+ L +
Sbjct: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKE 626
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 59.7 bits (143), Expect = 5e-09
Identities = 93/370 (25%), Positives = 150/370 (40%), Gaps = 67/370 (18%)
Query: 39 KEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQL 98
K+ + FVD DL L ++ P+ + + K T + F ++ VS I H L
Sbjct: 619 KDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQ 678
Query: 99 VDLKSELTETQAEKVVLEKEVH---DQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSV 155
L Q K +LE+ +H + L L S+ LQ A+ G + ++ G S
Sbjct: 679 YYL-------QLRKDILEERMHCDDETSLLLASLALQ--------AEYGDYQPEVHGVSY 723
Query: 156 EELERELEANKKEKMKEAQLEAEVKLLRK------ENEALRRHIAVLQAEV-YGARLAAK 208
+E L A EK+ + ++ E+ L E E + V Q YG
Sbjct: 724 FRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRV 783
Query: 209 YLDKE-----LAG---------------RVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHR 248
+ +K+ L G R ++ R+ K + K L+ +
Sbjct: 784 HPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK 843
Query: 249 H----------KTVIRACRGRNDLKRPMQAPPGH----DQDSLKKSQGV--GPIRKVLL- 291
H + ++ C ++ + M+A + D D L K + P R++ L
Sbjct: 844 HGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSSPEREITLV 903
Query: 292 -LKEDHE-GLGISITGGKEHG---VPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346
LK+D + GLG I GG++ G + I IS + PG PAD G L GD +++VN V+L
Sbjct: 904 NLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEG 963
Query: 347 TKHKEAVTIL 356
H A+ IL
Sbjct: 964 VSHHAAIEIL 973
Score = 53.9 bits (128), Expect = 3e-07
Identities = 39/113 (34%), Positives = 55/113 (48%), Gaps = 15/113 (13%)
Query: 284 GPIRKVLLLKEDHEGLGISITGGKEHGVP---ILISEIHPGQPADRCGGLHVGDAILAVN 340
G I +V L K D+ LGIS+TGG V I + + P A+ G +H GD +LAVN
Sbjct: 1173 GDIFEVELAKNDNS-LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVN 1231
Query: 341 GVNLRDTKHKEAV-----------TILSQQRGEIEFEVVYVAPEVDSDDENVE 382
GV+L HK+AV +L + + E V V P+ D+N +
Sbjct: 1232 GVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1284
Score = 42.4 bits (98), Expect = 9e-04
Identities = 28/96 (29%), Positives = 49/96 (51%), Gaps = 12/96 (12%)
Query: 292 LKEDHEGLGISITGGKEHGVP-------ILISEIHPGQPADRCGGLHVGDAILAVNGVNL 344
L ++ GLG S + +++ +P + + ++ PGQPA G + VGD IL VNG +L
Sbjct: 1313 LFKNSSGLGFSFSR-EDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1371
Query: 345 RDTKHKEAVTILSQQRGEIEFEVVY----VAPEVDS 376
+ +E ++ L E+ + V PE+D+
Sbjct: 1372 KGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDT 1407
Score = 32.3 bits (72), Expect = 0.93
Identities = 18/68 (26%), Positives = 35/68 (51%), Gaps = 2/68 (2%)
Query: 289 VLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTK 348
+ L+K + LG ++T G + + + ++ PA G L GD ++ VN ++ +
Sbjct: 1598 ITLIKSEKGSLGFTVTKGNQR-IGCYVHDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMT 1655
Query: 349 HKEAVTIL 356
H +AV +L
Sbjct: 1656 HTDAVNLL 1663
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 58.9 bits (141), Expect = 9e-09
Identities = 48/137 (35%), Positives = 67/137 (48%), Gaps = 18/137 (13%)
Query: 242 AEIHLHRHKTV--IRACRGRNDLKRPMQAPPGH----DQDSLKKSQGVGPIRKVLLLKED 295
A+ H+ + ++ + A + P Q PP + L + RK++L K
Sbjct: 334 ADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGS 393
Query: 296 HEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEA--- 352
GLG +I GG E G I +S I G PAD G L GD IL+VNGVNLR+ H++A
Sbjct: 394 -TGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAA 451
Query: 353 -------VTILSQQRGE 362
VTI++Q R E
Sbjct: 452 LKRAGQSVTIVAQYRPE 468
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/88 (40%), Positives = 50/88 (56%), Gaps = 8/88 (9%)
Query: 286 IRKVLLLKEDHEGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAILAV 339
I +V LLK +GLG SI GG +H +P I I++I G A + G L +GD +LAV
Sbjct: 224 IMEVNLLKGP-KGLGFSIAGGIGNQH-IPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAV 281
Query: 340 NGVNLRDTKHKEAVTILSQQRGEIEFEV 367
N NL+D +H+EAV L + +V
Sbjct: 282 NNTNLQDVRHEEAVASLKNTSDMVYLKV 309
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/74 (37%), Positives = 41/74 (55%), Gaps = 5/74 (6%)
Query: 290 LLLKEDHEGLGISITGGKEH-GVP----ILISEIHPGQPADRCGGLHVGDAILAVNGVNL 344
++L+ + GLG SI GG ++ VP I I++I PG A G L V D +L VN V++
Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
Query: 345 RDTKHKEAVTILSQ 358
+ H AV L +
Sbjct: 192 SEVVHSRAVEALKE 205
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 58.9 bits (141), Expect = 9e-09
Identities = 40/134 (29%), Positives = 71/134 (52%), Gaps = 13/134 (9%)
Query: 235 KLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKE 294
KL ++ + L H TV A + + + PM ++DS+K ++ L +
Sbjct: 97 KLLSKPNVKALLSVHDTV--AQKNYDPVLPPMPEDIDDEEDSVK----------IIRLVK 144
Query: 295 DHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVT 354
+ E LG +I ++ G I+++ I G ADR G +HVGD + VNG+ + D + +E +
Sbjct: 145 NREPLGATIKKDEQTGA-IIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQ 203
Query: 355 ILSQQRGEIEFEVV 368
IL+Q +G I F+++
Sbjct: 204 ILAQSQGAITFKII 217
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 58.5 bits (140), Expect = 1e-08
Identities = 40/86 (46%), Positives = 50/86 (58%), Gaps = 12/86 (13%)
Query: 287 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346
RK++L K GLG +I GG E G I +S I G PAD G L GD IL+VNGVNLR+
Sbjct: 48 RKIILHKGS-TGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 105
Query: 347 TKHKEA----------VTILSQQRGE 362
H++A VTI++Q R E
Sbjct: 106 ATHEQAAAALKRAGQSVTIVAQYRPE 131
>gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
Length = 1076
Score = 57.4 bits (137), Expect = 3e-08
Identities = 34/90 (37%), Positives = 52/90 (57%), Gaps = 1/90 (1%)
Query: 273 DQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHV 332
D+D+ + + G I + LK LGI+I+G +E PI+IS + G A+R G +H+
Sbjct: 605 DEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHI 664
Query: 333 GDAILAVNGVNLRDTKHKEAVTILSQQRGE 362
GD ILA+N +L+ EA+ +L Q GE
Sbjct: 665 GDRILAINSSSLKGKPLSEAIHLL-QMAGE 693
Score = 53.9 bits (128), Expect = 3e-07
Identities = 31/93 (33%), Positives = 48/93 (51%)
Query: 289 VLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTK 348
V L+K++ LG++++GG + +S + G A R L VGD I AVNG+NL +
Sbjct: 54 VELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFR 113
Query: 349 HKEAVTILSQQRGEIEFEVVYVAPEVDSDDENV 381
H E +++L + EV Y P V +V
Sbjct: 114 HDEIISLLKNVGERVVLEVEYELPPVSVQGSSV 146
Score = 52.8 bits (125), Expect = 7e-07
Identities = 31/89 (34%), Positives = 47/89 (52%), Gaps = 4/89 (4%)
Query: 292 LKEDHEGLGISITGG----KEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 347
L ++ G I GG + P++I+ + PG PADR G + GD +L+V+G+ L T
Sbjct: 155 LHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGT 214
Query: 348 KHKEAVTILSQQRGEIEFEVVYVAPEVDS 376
H EA++IL Q E + Y +DS
Sbjct: 215 THAEAMSILKQCGQEAALLIEYDVSVMDS 243
Score = 52.0 bits (123), Expect = 1e-06
Identities = 36/118 (30%), Positives = 64/118 (54%), Gaps = 11/118 (9%)
Query: 289 VLLLKEDHEGLGISITG--GKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346
V L K+ + LGI+I+ ++ G P++IS+I G A R G L +GD +LA++ + L +
Sbjct: 522 VKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDN 581
Query: 347 TKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNP 404
++AV IL Q ++ ++ D++N + ++ SG +Y EL+ G P
Sbjct: 582 CSMEDAVQILQQCEDLVKL-------KIRKDEDNSDEQESSG--AIIYTVELKRYGGP 630
Score = 51.2 bits (121), Expect = 2e-06
Identities = 32/90 (35%), Positives = 48/90 (53%), Gaps = 10/90 (11%)
Query: 288 KVLLLKEDHEGLGISITGG----KEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 343
+V+L + G GI + G + P LIS I PA+RCG L +GD ++A+NG+
Sbjct: 420 EVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIP 479
Query: 344 LRDTKHKEAVTIL------SQQRGEIEFEV 367
D+ +EA +L S+ EIEF+V
Sbjct: 480 TEDSTFEEASQLLRDSSITSKVTLEIEFDV 509
Score = 44.3 bits (103), Expect = 2e-04
Identities = 20/56 (35%), Positives = 33/56 (58%)
Query: 313 ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV 368
I+I +I ADRCG LHVGD IL+++G ++ EA L+ +++ E++
Sbjct: 278 IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL 333
>gi|41281808 harmonin isoform b3 [Homo sapiens]
Length = 899
Score = 55.8 bits (133), Expect = 8e-08
Identities = 41/145 (28%), Positives = 76/145 (52%), Gaps = 16/145 (11%)
Query: 265 PMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPA 324
P++ +DQ + ++S+ +++V L + EGLG+S+ GG E G + IS + G A
Sbjct: 67 PLKHQVEYDQLTPRRSR---KLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQA 123
Query: 325 DRCGGLHVGDAILAVNGVNLRDTKHKEAVTIL-SQQRGEIEFEVVYVAPEVDSDDENVEY 383
D GL VGD I+ +NG ++ H+E + ++ +++ I+ + + P S DE + +
Sbjct: 124 DSV-GLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTW 182
Query: 384 EDESGHRYRLYLDEL--EGGGNPGA 406
+ Y+D+ E GG G+
Sbjct: 183 Q---------YVDQFVSESGGVRGS 198
Score = 50.8 bits (120), Expect = 3e-06
Identities = 29/74 (39%), Positives = 39/74 (52%), Gaps = 1/74 (1%)
Query: 287 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346
+KV + GLG SI+ G I IS + PG + G L +GD I+ VNGV+ +
Sbjct: 210 KKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSN 268
Query: 347 TKHKEAVTILSQQR 360
HKEAV +L R
Sbjct: 269 LDHKEAVNVLKSSR 282
Score = 43.5 bits (101), Expect = 4e-04
Identities = 40/133 (30%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 262 LKRPMQAPPGHDQDSLKKSQGVGPI----------RKVLLLKEDHEG-LGISITGGKEHG 310
LKR + QD K +G P + V LL+ EG L +++ GG +
Sbjct: 716 LKRMVVYQTAFRQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSP 775
Query: 311 V-PILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQ---QRGEIEFE 366
+ +++S ++ A+R GG+ GD I+A+NG + D EA L + Q G+
Sbjct: 776 IGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDL 835
Query: 367 VVYVAPEVDSDDE 379
VV V P + DDE
Sbjct: 836 VVAVCPPKEYDDE 848
>gi|71480164 harmonin isoform a [Homo sapiens]
Length = 552
Score = 55.8 bits (133), Expect = 8e-08
Identities = 41/145 (28%), Positives = 76/145 (52%), Gaps = 16/145 (11%)
Query: 265 PMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPA 324
P++ +DQ + ++S+ +++V L + EGLG+S+ GG E G + IS + G A
Sbjct: 67 PLKHQVEYDQLTPRRSR---KLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQA 123
Query: 325 DRCGGLHVGDAILAVNGVNLRDTKHKEAVTIL-SQQRGEIEFEVVYVAPEVDSDDENVEY 383
D GL VGD I+ +NG ++ H+E + ++ +++ I+ + + P S DE + +
Sbjct: 124 DSV-GLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTW 182
Query: 384 EDESGHRYRLYLDEL--EGGGNPGA 406
+ Y+D+ E GG G+
Sbjct: 183 Q---------YVDQFVSESGGVRGS 198
Score = 50.8 bits (120), Expect = 3e-06
Identities = 29/74 (39%), Positives = 39/74 (52%), Gaps = 1/74 (1%)
Query: 287 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346
+KV + GLG SI+ G I IS + PG + G L +GD I+ VNGV+ +
Sbjct: 210 KKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSN 268
Query: 347 TKHKEAVTILSQQR 360
HKEAV +L R
Sbjct: 269 LDHKEAVNVLKSSR 282
Score = 42.7 bits (99), Expect = 7e-04
Identities = 37/122 (30%), Positives = 59/122 (48%), Gaps = 15/122 (12%)
Query: 273 DQDSLKKSQGVGPI----------RKVLLLKEDHEG-LGISITGGKEHGV-PILISEIHP 320
+QD K +G P + V LL+ EG L +++ GG + + +++S ++
Sbjct: 427 EQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYE 486
Query: 321 GQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQ---QRGEIEFEVVYVAPEVDSD 377
A+R GG+ GD I+A+NG + D EA L + Q G+ VV V P + D
Sbjct: 487 RGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYD 546
Query: 378 DE 379
DE
Sbjct: 547 DE 548
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 55.5 bits (132), Expect = 1e-07
Identities = 35/73 (47%), Positives = 43/73 (58%), Gaps = 2/73 (2%)
Query: 284 GPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 343
G RKV+L K GLG +I GG E G I +S I G PAD G L GD IL+VNG++
Sbjct: 314 GEPRKVVLHKGS-TGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 371
Query: 344 LRDTKHKEAVTIL 356
LR H++A L
Sbjct: 372 LRGASHEQAAAAL 384
Score = 45.8 bits (107), Expect = 8e-05
Identities = 32/80 (40%), Positives = 44/80 (55%), Gaps = 12/80 (15%)
Query: 297 EGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHK 350
+GLG SI GG +H +P I +++I G A + G L VGD +L VN +L + H+
Sbjct: 150 KGLGFSIAGGVGNQH-IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 208
Query: 351 EAVTILSQQRGEIEFEVVYV 370
EAV IL EVVY+
Sbjct: 209 EAVAILKNTS-----EVVYL 223
Score = 44.7 bits (104), Expect = 2e-04
Identities = 27/74 (36%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 290 LLLKEDHEGLGISITGGKEH-----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNL 344
+ L+ + GLG SI GG ++ I I++I PG A G L V D IL VN V++
Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
Query: 345 RDTKHKEAVTILSQ 358
+ H +AV L +
Sbjct: 108 SEVSHSKAVEALKE 121
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 55.5 bits (132), Expect = 1e-07
Identities = 35/73 (47%), Positives = 43/73 (58%), Gaps = 2/73 (2%)
Query: 284 GPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 343
G RKV+L K GLG +I GG E G I +S I G PAD G L GD IL+VNG++
Sbjct: 522 GEPRKVVLHKGS-TGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 579
Query: 344 LRDTKHKEAVTIL 356
LR H++A L
Sbjct: 580 LRGASHEQAAAAL 592
Score = 45.8 bits (107), Expect = 8e-05
Identities = 32/80 (40%), Positives = 44/80 (55%), Gaps = 12/80 (15%)
Query: 297 EGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHK 350
+GLG SI GG +H +P I +++I G A + G L VGD +L VN +L + H+
Sbjct: 306 KGLGFSIAGGVGNQH-IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 364
Query: 351 EAVTILSQQRGEIEFEVVYV 370
EAV IL EVVY+
Sbjct: 365 EAVAILKNTS-----EVVYL 379
Score = 44.7 bits (104), Expect = 2e-04
Identities = 27/74 (36%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 290 LLLKEDHEGLGISITGGKEH-----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNL 344
+ L+ + GLG SI GG ++ I I++I PG A G L V D IL VN V++
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
Query: 345 RDTKHKEAVTILSQ 358
+ H +AV L +
Sbjct: 264 SEVSHSKAVEALKE 277
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 55.5 bits (132), Expect = 1e-07
Identities = 35/73 (47%), Positives = 43/73 (58%), Gaps = 2/73 (2%)
Query: 284 GPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 343
G RKV+L K GLG +I GG E G I +S I G PAD G L GD IL+VNG++
Sbjct: 417 GEPRKVVLHKGS-TGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 474
Query: 344 LRDTKHKEAVTIL 356
LR H++A L
Sbjct: 475 LRGASHEQAAAAL 487
Score = 45.8 bits (107), Expect = 8e-05
Identities = 32/80 (40%), Positives = 44/80 (55%), Gaps = 12/80 (15%)
Query: 297 EGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHK 350
+GLG SI GG +H +P I +++I G A + G L VGD +L VN +L + H+
Sbjct: 201 KGLGFSIAGGVGNQH-IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 259
Query: 351 EAVTILSQQRGEIEFEVVYV 370
EAV IL EVVY+
Sbjct: 260 EAVAILKNTS-----EVVYL 274
Score = 44.7 bits (104), Expect = 2e-04
Identities = 27/74 (36%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 290 LLLKEDHEGLGISITGGKEH-----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNL 344
+ L+ + GLG SI GG ++ I I++I PG A G L V D IL VN V++
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 345 RDTKHKEAVTILSQ 358
+ H +AV L +
Sbjct: 159 SEVSHSKAVEALKE 172
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 55.5 bits (132), Expect = 1e-07
Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 8/82 (9%)
Query: 284 GPIRK--VLLLKEDHEGLGISITGGKEH------GVPILISEIHPGQPADRCGGLHVGDA 335
GP+R+ V L GLG SI GGK I +S I G A R G L VGD
Sbjct: 855 GPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDR 914
Query: 336 ILAVNGVNLRDTKHKEAVTILS 357
+L++NGV++ + +H AV++L+
Sbjct: 915 VLSINGVDVTEARHDHAVSLLT 936
Score = 50.1 bits (118), Expect = 4e-06
Identities = 35/84 (41%), Positives = 49/84 (58%), Gaps = 10/84 (11%)
Query: 281 QGVGPIRKVLLLKEDHEGLGISITGGKEH-----GVP---ILISEIHPGQPADRCGGLHV 332
+G P+ ++ L + LG+SI GG +H GV + IS++ P A R GL V
Sbjct: 997 EGPYPVEEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLRV 1054
Query: 333 GDAILAVNGVNLRDTKHKEAVTIL 356
GD ILAVNG ++RD H+EAV+ L
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSAL 1078
Score = 44.7 bits (104), Expect = 2e-04
Identities = 31/67 (46%), Positives = 37/67 (55%), Gaps = 11/67 (16%)
Query: 298 GLGISITGGK--------EHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 349
GLGISI GGK + G I IS + PA R G + VGD +L VNGV L+ +H
Sbjct: 737 GLGISIAGGKGSTPYKGDDEG--IFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793
Query: 350 KEAVTIL 356
EAV L
Sbjct: 794 HEAVEAL 800
Score = 43.1 bits (100), Expect = 5e-04
Identities = 40/121 (33%), Positives = 52/121 (42%), Gaps = 23/121 (19%)
Query: 245 HLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISIT 304
H ++R C + L R APPG +R++ + K E LGISI
Sbjct: 1071 HQEAVSALLRPCLELSLLVRRDPAPPG--------------LRELCIQKAPGERLGISIR 1116
Query: 305 GGK--EHGVP-------ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTI 355
GG G P I IS++ P A R G L VG +L VN +L H EAV +
Sbjct: 1117 GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQL 1176
Query: 356 L 356
L
Sbjct: 1177 L 1177
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 55.5 bits (132), Expect = 1e-07
Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 8/82 (9%)
Query: 284 GPIRK--VLLLKEDHEGLGISITGGKEH------GVPILISEIHPGQPADRCGGLHVGDA 335
GP+R+ V L GLG SI GGK I +S I G A R G L VGD
Sbjct: 855 GPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDR 914
Query: 336 ILAVNGVNLRDTKHKEAVTILS 357
+L++NGV++ + +H AV++L+
Sbjct: 915 VLSINGVDVTEARHDHAVSLLT 936
Score = 50.1 bits (118), Expect = 4e-06
Identities = 35/84 (41%), Positives = 49/84 (58%), Gaps = 10/84 (11%)
Query: 281 QGVGPIRKVLLLKEDHEGLGISITGGKEH-----GVP---ILISEIHPGQPADRCGGLHV 332
+G P+ ++ L + LG+SI GG +H GV + IS++ P A R GL V
Sbjct: 997 EGPYPVEEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLRV 1054
Query: 333 GDAILAVNGVNLRDTKHKEAVTIL 356
GD ILAVNG ++RD H+EAV+ L
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSAL 1078
Score = 44.7 bits (104), Expect = 2e-04
Identities = 31/67 (46%), Positives = 37/67 (55%), Gaps = 11/67 (16%)
Query: 298 GLGISITGGK--------EHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 349
GLGISI GGK + G I IS + PA R G + VGD +L VNGV L+ +H
Sbjct: 737 GLGISIAGGKGSTPYKGDDEG--IFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793
Query: 350 KEAVTIL 356
EAV L
Sbjct: 794 HEAVEAL 800
Score = 43.1 bits (100), Expect = 5e-04
Identities = 40/121 (33%), Positives = 52/121 (42%), Gaps = 23/121 (19%)
Query: 245 HLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISIT 304
H ++R C + L R APPG +R++ + K E LGISI
Sbjct: 1071 HQEAVSALLRPCLELSLLVRRDPAPPG--------------LRELCIQKAPGERLGISIR 1116
Query: 305 GGK--EHGVP-------ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTI 355
GG G P I IS++ P A R G L VG +L VN +L H EAV +
Sbjct: 1117 GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQL 1176
Query: 356 L 356
L
Sbjct: 1177 L 1177
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 55.1 bits (131), Expect = 1e-07
Identities = 35/83 (42%), Positives = 47/83 (56%), Gaps = 11/83 (13%)
Query: 290 LLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 349
+++ GLG +I GG E G I IS I G PAD G L GD IL+VNGV+LR+ H
Sbjct: 357 IVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASH 415
Query: 350 KEA----------VTILSQQRGE 362
++A VTI++Q + E
Sbjct: 416 EQAAIALKNAGQTVTIIAQYKPE 438
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/94 (38%), Positives = 52/94 (55%), Gaps = 14/94 (14%)
Query: 285 PIRKVLLLK--EDHEGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAI 336
P KV+ +K + +GLG SI GG +H +P I +++I G A + G L +GD I
Sbjct: 197 PAEKVMEIKLIKGPKGLGFSIAGGVGNQH-IPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 255
Query: 337 LAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYV 370
LAVN V L D H++AV L ++VVY+
Sbjct: 256 LAVNSVGLEDVMHEDAVAALKN-----TYDVVYL 284
Score = 47.4 bits (111), Expect = 3e-05
Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 290 LLLKEDHEGLGISITGGKEH-----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNL 344
+ L+ + GLG SI GG ++ I I++I PG A + G L V D+IL VN V++
Sbjct: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
Query: 345 RDTKHKEAVTILSQQRGEIEFEVVYVAPEVD 375
R+ H AV L + + V+ P +
Sbjct: 169 REVTHSAAVEALKEAGSIVRLYVMRRKPPAE 199
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 55.1 bits (131), Expect = 1e-07
Identities = 35/83 (42%), Positives = 47/83 (56%), Gaps = 11/83 (13%)
Query: 290 LLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 349
+++ GLG +I GG E G I IS I G PAD G L GD IL+VNGV+LR+ H
Sbjct: 311 IVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASH 369
Query: 350 KEA----------VTILSQQRGE 362
++A VTI++Q + E
Sbjct: 370 EQAAIALKNAGQTVTIIAQYKPE 392
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/94 (38%), Positives = 52/94 (55%), Gaps = 14/94 (14%)
Query: 285 PIRKVLLLK--EDHEGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAI 336
P KV+ +K + +GLG SI GG +H +P I +++I G A + G L +GD I
Sbjct: 151 PAEKVMEIKLIKGPKGLGFSIAGGVGNQH-IPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 209
Query: 337 LAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYV 370
LAVN V L D H++AV L ++VVY+
Sbjct: 210 LAVNSVGLEDVMHEDAVAALKN-----TYDVVYL 238
Score = 47.4 bits (111), Expect = 3e-05
Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 290 LLLKEDHEGLGISITGGKEH-----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNL 344
+ L+ + GLG SI GG ++ I I++I PG A + G L V D+IL VN V++
Sbjct: 63 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122
Query: 345 RDTKHKEAVTILSQQRGEIEFEVVYVAPEVD 375
R+ H AV L + + V+ P +
Sbjct: 123 REVTHSAAVEALKEAGSIVRLYVMRRKPPAE 153
>gi|122937249 glutamate receptor interacting protein 2 [Homo
sapiens]
Length = 1141
Score = 55.1 bits (131), Expect = 1e-07
Identities = 30/87 (34%), Positives = 48/87 (55%)
Query: 286 IRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLR 345
I V L+K++ LG++I+GG + +S + PG A R L++GD I +VNG++L
Sbjct: 143 ITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLT 202
Query: 346 DTKHKEAVTILSQQRGEIEFEVVYVAP 372
+H E +T+L + EV Y P
Sbjct: 203 RLRHDEIITLLKNVGERVVLEVEYELP 229
Score = 54.7 bits (130), Expect = 2e-07
Identities = 34/90 (37%), Positives = 52/90 (57%), Gaps = 1/90 (1%)
Query: 273 DQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHV 332
D+D+ + + G + + LK LGI+I+G +E PI+IS + A+R G +HV
Sbjct: 738 DEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHV 797
Query: 333 GDAILAVNGVNLRDTKHKEAVTILSQQRGE 362
GD ILA+N V+L+ EA+ +L Q GE
Sbjct: 798 GDRILAINNVSLKGRPLSEAIHLL-QVAGE 826
Score = 50.8 bits (120), Expect = 3e-06
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 292 LKEDHEGLGISITGGKEH----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 347
L ++ G + GG P++++ + PG PADR G L VGD +L+V+G+ L
Sbjct: 248 LYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGA 307
Query: 348 KHKEAVTILSQQRGEIEFEVVY 369
H A+ L Q E F+V Y
Sbjct: 308 SHATALATLRQCSHEALFQVEY 329
Score = 49.3 bits (116), Expect = 7e-06
Identities = 38/127 (29%), Positives = 55/127 (43%), Gaps = 18/127 (14%)
Query: 259 RNDLKRPMQAPPGHDQDSLKKSQGVGP--------IRKVLLLKEDHEGLGISITGG---- 306
R + R Q H S VGP +V+L + G G+ + GG
Sbjct: 517 RTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFAT 576
Query: 307 KEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR------ 360
+ P L+ I P PA+RCG L VGD +L++NG+ D +EA +L
Sbjct: 577 ETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVV 636
Query: 361 GEIEFEV 367
E+EF+V
Sbjct: 637 LEVEFDV 643
Score = 47.0 bits (110), Expect = 4e-05
Identities = 39/143 (27%), Positives = 66/143 (46%), Gaps = 11/143 (7%)
Query: 289 VLLLKEDHEGLGISITGG-KEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 347
V L K+ LGI+I+ ++ G P++IS+I G A R G L GD +LA++ + L +
Sbjct: 656 VKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNC 715
Query: 348 KHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGAS 407
++AV IL Q ++ ++ +D + E E Y + L GG G +
Sbjct: 716 PMEDAVQILRQCEDLVKLKI------RKDEDNSDELETTGAVSYTVELKRY--GGPLGIT 767
Query: 408 CKDTSGEIK--VLQGFNKKAVTD 428
T V+ G K+ + +
Sbjct: 768 ISGTEEPFDPIVISGLTKRGLAE 790
Score = 43.5 bits (101), Expect = 4e-04
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 2/88 (2%)
Query: 284 GPIRKVLLLKEDHEGLGISITGGKEHGVPIL-ISEIHPGQPADRCGGLHVGDAILAVNGV 342
GP+ V ++K LGIS+T ++ I I P DR G LH GD IL+++G
Sbjct: 342 GPLM-VEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGT 400
Query: 343 NLRDTKHKEAVTILSQQRGEIEFEVVYV 370
++ EA +L+ ++ E++ V
Sbjct: 401 SMEHCSLLEATKLLASISEKVRLEILPV 428
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 55.1 bits (131), Expect = 1e-07
Identities = 35/88 (39%), Positives = 50/88 (56%), Gaps = 4/88 (4%)
Query: 283 VGPIRKVLLLKEDHEGLGISITGG---KEHGVPILISEIHPGQPADRCGGLHVGDAILAV 339
VG I K+ LLKE +GLGI ++GG K I+++++ G A R G L +GD +L +
Sbjct: 329 VGRIWKMELLKES-DGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVI 387
Query: 340 NGVNLRDTKHKEAVTILSQQRGEIEFEV 367
NG L H+EAV IL G ++ V
Sbjct: 388 NGHLLVGLSHEEAVAILRSATGMVQLVV 415
Score = 43.9 bits (102), Expect = 3e-04
Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 19/148 (12%)
Query: 225 GRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPM--QAPPGHDQDSLKKSQ- 281
G + G AH N L+ HK + + D RP Q PP + L +
Sbjct: 2676 GASLAGLAHG---NVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKT 2732
Query: 282 -----GVG---PIRKVLLLK--EDHEGLGISITGGKEHGV---PILISEIHPGQPADRCG 328
G+G + L ++ + GLG+S+ GGK P++I ++ G A++ G
Sbjct: 2733 IPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAG 2792
Query: 329 GLHVGDAILAVNGVNLRDTKHKEAVTIL 356
+ GD ILA+NG L H +A I+
Sbjct: 2793 IIEAGDEILAINGKPLVGLMHFDAWNIM 2820
Score = 43.1 bits (100), Expect = 5e-04
Identities = 27/73 (36%), Positives = 37/73 (50%), Gaps = 3/73 (4%)
Query: 291 LLKEDHEGLGISITGGKE---HGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 347
L KE +GLG SI GG++ + I + I P A G L GD IL VNG+ ++
Sbjct: 589 LYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648
Query: 348 KHKEAVTILSQQR 360
+EA+ Q R
Sbjct: 649 TFQEAIHTFKQIR 661
Score = 38.5 bits (88), Expect = 0.013
Identities = 22/86 (25%), Positives = 44/86 (51%), Gaps = 1/86 (1%)
Query: 274 QDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKE-HGVPILISEIHPGQPADRCGGLHV 332
Q++ +S+ + ++L +++ GLG S+ GG + I + + A + G ++
Sbjct: 2608 QEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNR 2667
Query: 333 GDAILAVNGVNLRDTKHKEAVTILSQ 358
GD +L+VNG +L H + +L Q
Sbjct: 2668 GDFLLSVNGASLAGLAHGNVLKVLHQ 2693
Score = 35.0 bits (79), Expect = 0.14
Identities = 28/75 (37%), Positives = 35/75 (46%), Gaps = 2/75 (2%)
Query: 286 IRKVLLLKEDHEGLGISITG-GKEHGVP-ILISEIHPGQPADRCGGLHVGDAILAVNGVN 343
+ +V L KE GLGI E+ P I I + PG A L GD IL VN VN
Sbjct: 726 VMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVN 785
Query: 344 LRDTKHKEAVTILSQ 358
+R + ILS+
Sbjct: 786 VRHAALSKVHAILSK 800
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 54.7 bits (130), Expect = 2e-07
Identities = 21/65 (32%), Positives = 39/65 (60%)
Query: 292 LKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKE 351
L+ +G G S+ GG+E+ + + + + PA+RCG + +GD IL +NG ++ KH
Sbjct: 1155 LERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSR 1214
Query: 352 AVTIL 356
A+ ++
Sbjct: 1215 AIELI 1219
Score = 51.6 bits (122), Expect = 1e-06
Identities = 24/69 (34%), Positives = 36/69 (52%)
Query: 300 GISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQ 359
G + G +P I I G PADRCG L VGD ILAVNG ++ + H + V ++ +
Sbjct: 1023 GTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEA 1082
Query: 360 RGEIEFEVV 368
+ ++
Sbjct: 1083 GNTVTLRII 1091
Score = 45.8 bits (107), Expect = 8e-05
Identities = 28/94 (29%), Positives = 45/94 (47%), Gaps = 6/94 (6%)
Query: 290 LLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 349
+ L G G I GG E G PI I I P AD G L GD ++ V+G + H
Sbjct: 842 IFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSH 901
Query: 350 KEAVTILSQ--QRGEIEF----EVVYVAPEVDSD 377
+ V ++ Q ++G + +VV+ P+ +++
Sbjct: 902 QLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENE 935
Score = 32.0 bits (71), Expect = 1.2
Identities = 21/105 (20%), Positives = 44/105 (41%), Gaps = 5/105 (4%)
Query: 278 KKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGG-----LHV 332
KK+ + + + + LG+++ GG EHG + + + A GG L
Sbjct: 7 KKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGE 66
Query: 333 GDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSD 377
G+ +L V GV + + + ++ + + F+ V ++ D
Sbjct: 67 GELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKD 111
Score = 32.0 bits (71), Expect = 1.2
Identities = 18/64 (28%), Positives = 29/64 (45%)
Query: 292 LKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKE 351
L++ G G ++ GG E + I + PA G + GD I++VN + H +
Sbjct: 475 LRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
Query: 352 AVTI 355
V I
Sbjct: 535 VVKI 538
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 54.7 bits (130), Expect = 2e-07
Identities = 21/65 (32%), Positives = 39/65 (60%)
Query: 292 LKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKE 351
L+ +G G S+ GG+E+ + + + + PA+RCG + +GD IL +NG ++ KH
Sbjct: 1126 LERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSR 1185
Query: 352 AVTIL 356
A+ ++
Sbjct: 1186 AIELI 1190
Score = 50.1 bits (118), Expect = 4e-06
Identities = 22/58 (37%), Positives = 33/58 (56%)
Query: 311 VPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV 368
+P I I G PADRCG L VGD ILAVNG ++ + H + V ++ + + ++
Sbjct: 1005 MPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1062
Score = 45.8 bits (107), Expect = 8e-05
Identities = 28/94 (29%), Positives = 45/94 (47%), Gaps = 6/94 (6%)
Query: 290 LLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 349
+ L G G I GG E G PI I I P AD G L GD ++ V+G + H
Sbjct: 814 IFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSH 873
Query: 350 KEAVTILSQ--QRGEIEF----EVVYVAPEVDSD 377
+ V ++ Q ++G + +VV+ P+ +++
Sbjct: 874 QLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENE 907
Score = 32.0 bits (71), Expect = 1.2
Identities = 21/105 (20%), Positives = 44/105 (41%), Gaps = 5/105 (4%)
Query: 278 KKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGG-----LHV 332
KK+ + + + + LG+++ GG EHG + + + A GG L
Sbjct: 7 KKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGE 66
Query: 333 GDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSD 377
G+ +L V GV + + + ++ + + F+ V ++ D
Sbjct: 67 GELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKD 111
Score = 32.0 bits (71), Expect = 1.2
Identities = 18/64 (28%), Positives = 29/64 (45%)
Query: 292 LKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKE 351
L++ G G ++ GG E + I + PA G + GD I++VN + H +
Sbjct: 475 LRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
Query: 352 AVTI 355
V I
Sbjct: 535 VVKI 538
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.133 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,101,513
Number of Sequences: 37866
Number of extensions: 920402
Number of successful extensions: 5816
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 195
Number of HSP's successfully gapped in prelim test: 412
Number of HSP's that attempted gapping in prelim test: 4531
Number of HSP's gapped (non-prelim): 1528
length of query: 462
length of database: 18,247,518
effective HSP length: 106
effective length of query: 356
effective length of database: 14,233,722
effective search space: 5067205032
effective search space used: 5067205032
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.