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Search of human proteins with 7706025
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7706025 PDZ domain containing 11 [Homo sapiens]
(140 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7706025 PDZ domain containing 11 [Homo sapiens] 293 2e-80
gi|13376349 PDZ domain containing 7 [Homo sapiens] 70 6e-13
gi|4759306 lin-7 homolog A [Homo sapiens] 67 5e-12
gi|11545920 lin-7 homolog B [Homo sapiens] 67 5e-12
gi|8922944 lin-7 homolog C [Homo sapiens] 66 8e-12
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 64 5e-11
gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchan... 61 3e-10
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 61 3e-10
gi|41281808 harmonin isoform b3 [Homo sapiens] 60 6e-10
gi|71480164 harmonin isoform a [Homo sapiens] 60 6e-10
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 56 8e-09
gi|45827729 scribble isoform b [Homo sapiens] 56 1e-08
gi|45827731 scribble isoform a [Homo sapiens] 56 1e-08
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 55 2e-08
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 55 2e-08
gi|10092691 tight junction protein 3 [Homo sapiens] 55 2e-08
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 54 3e-08
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 54 4e-08
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 54 4e-08
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 54 4e-08
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 54 4e-08
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 54 4e-08
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 54 4e-08
gi|5803177 basic beta 2 syntrophin [Homo sapiens] 54 4e-08
gi|9507165 syntrophin, gamma 2 [Homo sapiens] 54 5e-08
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 53 7e-08
gi|112382257 InaD-like [Homo sapiens] 53 7e-08
gi|4507137 acidic alpha 1 syntrophin [Homo sapiens] 53 7e-08
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 53 9e-08
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 53 9e-08
>gi|7706025 PDZ domain containing 11 [Homo sapiens]
Length = 140
Score = 293 bits (751), Expect = 2e-80
Identities = 140/140 (100%), Positives = 140/140 (100%)
Query: 1 MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGF 60
MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGF
Sbjct: 1 MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGF 60
Query: 61 NIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREI 120
NIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREI
Sbjct: 61 NIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREI 120
Query: 121 SMRVRFFPYNYHRQKERTVH 140
SMRVRFFPYNYHRQKERTVH
Sbjct: 121 SMRVRFFPYNYHRQKERTVH 140
>gi|13376349 PDZ domain containing 7 [Homo sapiens]
Length = 517
Score = 70.1 bits (170), Expect = 6e-13
Identities = 36/68 (52%), Positives = 45/68 (66%)
Query: 58 LGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTA 117
LGFNIRGGK LGI++SKV A G++ GDQVLA N V F DI HS+AVE+LK
Sbjct: 222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQ 281
Query: 118 REISMRVR 125
I + ++
Sbjct: 282 THIMLTIK 289
Score = 64.3 bits (155), Expect = 3e-11
Identities = 31/79 (39%), Positives = 48/79 (60%)
Query: 47 TITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIE 106
++ ++K P +LGF++RGG LGIF+SKV S A RAGL GD++ VN + +
Sbjct: 86 SVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTT 145
Query: 107 HSKAVEILKTAREISMRVR 125
AV++L ++ + M VR
Sbjct: 146 MGSAVKVLTSSSRLHMMVR 164
>gi|4759306 lin-7 homolog A [Homo sapiens]
Length = 233
Score = 67.0 bits (162), Expect = 5e-12
Identities = 38/86 (44%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Query: 45 PRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHR-AGLQEGDQVLAVNDVDFQ 103
PR + L K LGFN+ GGK I+IS++IP A R GL+ GDQ+L+VN V +
Sbjct: 106 PRVVELPKTDEG-LGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVE 164
Query: 104 DIEHSKAVEILKTARE-ISMRVRFFP 128
H KAVE+LK A++ + + VR+ P
Sbjct: 165 GEHHEKAVELLKAAKDSVKLVVRYTP 190
>gi|11545920 lin-7 homolog B [Homo sapiens]
Length = 207
Score = 67.0 bits (162), Expect = 5e-12
Identities = 40/86 (46%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Query: 45 PRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHR-AGLQEGDQVLAVNDVDFQ 103
PR + L K LGFNI GGK I+IS+VIP A R GL+ GDQ+L+VN V +
Sbjct: 91 PRVVELPKTDEG-LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVE 149
Query: 104 DIEHSKAVEILKTAR-EISMRVRFFP 128
+H KAVE+LK A+ + + VR+ P
Sbjct: 150 GEQHEKAVELLKAAQGSVKLVVRYTP 175
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 66.2 bits (160), Expect = 8e-12
Identities = 39/86 (45%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Query: 45 PRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHR-AGLQEGDQVLAVNDVDFQ 103
PR + L K LGFNI GGK I+IS++IP A R GL+ GDQ+L+VN V +
Sbjct: 91 PRVVELPKTEEG-LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVE 149
Query: 104 DIEHSKAVEILKTAR-EISMRVRFFP 128
H KAVE+LK A+ ++ + VR+ P
Sbjct: 150 GEHHEKAVELLKAAQGKVKLVVRYTP 175
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 63.5 bits (153), Expect = 5e-11
Identities = 33/80 (41%), Positives = 49/80 (61%)
Query: 46 RTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDI 105
+ + L G LG IRGG LGI+I+ V P S+A +GL+ GDQ+L VN F +I
Sbjct: 278 KKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNI 337
Query: 106 EHSKAVEILKTAREISMRVR 125
H +AV +LK++R + + V+
Sbjct: 338 LHDEAVRLLKSSRHLILTVK 357
Score = 60.8 bits (146), Expect = 3e-10
Identities = 31/80 (38%), Positives = 52/80 (65%), Gaps = 1/80 (1%)
Query: 46 RTITLKKPPGAQ-LGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQD 104
R ++L++ + LGF+IRGG +GI++S V P S A + GL+ GDQ+L VND
Sbjct: 139 RLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLAR 198
Query: 105 IEHSKAVEILKTAREISMRV 124
+ H++AV+ LK ++++ + V
Sbjct: 199 VTHAEAVKALKGSKKLVLSV 218
>gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchange
factor 2, partial [Homo sapiens]
Length = 803
Score = 60.8 bits (146), Expect = 3e-10
Identities = 35/81 (43%), Positives = 49/81 (60%), Gaps = 1/81 (1%)
Query: 46 RTITLKKPPG-AQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQD 104
R +TL KP A L F + GG GIF+ V S A AGL+ GDQ+L VN +F++
Sbjct: 384 RLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFEN 443
Query: 105 IEHSKAVEILKTAREISMRVR 125
I+ SKA+EIL+ +S+ V+
Sbjct: 444 IQLSKAMEILRNNTHLSITVK 464
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 60.8 bits (146), Expect = 3e-10
Identities = 35/81 (43%), Positives = 49/81 (60%), Gaps = 1/81 (1%)
Query: 46 RTITLKKPPG-AQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQD 104
R +TL KP A L F + GG GIF+ V S A AGL+ GDQ+L VN +F++
Sbjct: 384 RLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFEN 443
Query: 105 IEHSKAVEILKTAREISMRVR 125
I+ SKA+EIL+ +S+ V+
Sbjct: 444 IQLSKAMEILRNNTHLSITVK 464
>gi|41281808 harmonin isoform b3 [Homo sapiens]
Length = 899
Score = 60.1 bits (144), Expect = 6e-10
Identities = 28/67 (41%), Positives = 45/67 (67%)
Query: 58 LGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTA 117
LG +I G + GIFIS V P S + GL+ GDQ++ VN VDF +++H +AV +LK++
Sbjct: 222 LGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSS 281
Query: 118 REISMRV 124
R +++ +
Sbjct: 282 RSLTISI 288
Score = 53.9 bits (128), Expect = 4e-08
Identities = 29/111 (26%), Positives = 55/111 (49%), Gaps = 1/111 (0%)
Query: 15 LPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFI 74
LP ++ IP +V + ++ L + + L + LG ++RGG G+FI
Sbjct: 56 LPLFDAIRPLIPLKHQVEYDQLTPRRSRKL-KEVRLDRLHPEGLGLSVRGGLEFGCGLFI 114
Query: 75 SKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVR 125
S +I A GLQ GD+++ +N H + + +++T + +S++VR
Sbjct: 115 SHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVR 165
Score = 26.9 bits (58), Expect = 5.5
Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 4/74 (5%)
Query: 46 RTITLKKPPGAQLGFNIRGGKASQLG-IFISKVIPDSDAHR-AGLQEGDQVLAVNDVDFQ 103
R + +KK L + GG S +G + +S V A R G+ +GD+++A+N
Sbjct: 754 RLLRIKKEGSLDLA--LEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVT 811
Query: 104 DIEHSKAVEILKTA 117
D ++A L+ A
Sbjct: 812 DYTLAEAEAALQKA 825
>gi|71480164 harmonin isoform a [Homo sapiens]
Length = 552
Score = 60.1 bits (144), Expect = 6e-10
Identities = 28/67 (41%), Positives = 45/67 (67%)
Query: 58 LGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTA 117
LG +I G + GIFIS V P S + GL+ GDQ++ VN VDF +++H +AV +LK++
Sbjct: 222 LGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSS 281
Query: 118 REISMRV 124
R +++ +
Sbjct: 282 RSLTISI 288
Score = 53.9 bits (128), Expect = 4e-08
Identities = 29/111 (26%), Positives = 55/111 (49%), Gaps = 1/111 (0%)
Query: 15 LPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFI 74
LP ++ IP +V + ++ L + + L + LG ++RGG G+FI
Sbjct: 56 LPLFDAIRPLIPLKHQVEYDQLTPRRSRKL-KEVRLDRLHPEGLGLSVRGGLEFGCGLFI 114
Query: 75 SKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVR 125
S +I A GLQ GD+++ +N H + + +++T + +S++VR
Sbjct: 115 SHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVR 165
Score = 26.9 bits (58), Expect = 5.5
Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 4/74 (5%)
Query: 46 RTITLKKPPGAQLGFNIRGGKASQLG-IFISKVIPDSDAHR-AGLQEGDQVLAVNDVDFQ 103
R + +KK L + GG S +G + +S V A R G+ +GD+++A+N
Sbjct: 454 RLLRIKKEGSLDLA--LEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVT 511
Query: 104 DIEHSKAVEILKTA 117
D ++A L+ A
Sbjct: 512 DYTLAEAEAALQKA 525
>gi|54633319 PDZ domain-containing guanine nucleotide exchange
factor I [Homo sapiens]
Length = 1601
Score = 56.2 bits (134), Expect = 8e-09
Identities = 30/81 (37%), Positives = 48/81 (59%), Gaps = 1/81 (1%)
Query: 46 RTITLKKPPG-AQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQD 104
R + L+K + L F++ GG GIF+ V P S A +GL+ GDQ++ VN +F++
Sbjct: 529 RQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFEN 588
Query: 105 IEHSKAVEILKTAREISMRVR 125
I KAVEIL+ +++ V+
Sbjct: 589 ITFMKAVEILRNNTHLALTVK 609
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 55.8 bits (133), Expect = 1e-08
Identities = 37/85 (43%), Positives = 50/85 (58%), Gaps = 8/85 (9%)
Query: 47 TITLKKPPGAQLGFNIRGGKAS------QLGIFISKVIPDSDAHRAGLQEGDQVLAVNDV 100
T+T+ + G LG +I GGK S GIFIS+V + A RAG++ GD++L VN V
Sbjct: 728 TLTILRQTGG-LGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGV 786
Query: 101 DFQDIEHSKAVEILKTA-REISMRV 124
Q EH +AVE L+ A + MRV
Sbjct: 787 ALQGAEHHEAVEALRGAGTAVQMRV 811
Score = 55.8 bits (133), Expect = 1e-08
Identities = 34/83 (40%), Positives = 48/83 (57%), Gaps = 9/83 (10%)
Query: 55 GAQLGFNIRGGK--------ASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIE 106
G LG +I GG + G+FISKV+P A R+GL+ GD++LAVN D +D
Sbjct: 1011 GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDAT 1070
Query: 107 HSKAVE-ILKTAREISMRVRFFP 128
H +AV +L+ E+S+ VR P
Sbjct: 1071 HQEAVSALLRPCLELSLLVRRDP 1093
Score = 55.1 bits (131), Expect = 2e-08
Identities = 31/67 (46%), Positives = 40/67 (59%), Gaps = 7/67 (10%)
Query: 58 LGFNIRGGKAS------QLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKA 110
LGF+I GGK S GIF+S++ AHRAG LQ GD+VL++N VD + H A
Sbjct: 872 LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHA 931
Query: 111 VEILKTA 117
V +L A
Sbjct: 932 VSLLTAA 938
Score = 47.8 bits (112), Expect = 3e-06
Identities = 30/81 (37%), Positives = 44/81 (54%), Gaps = 10/81 (12%)
Query: 46 RTITLKKPPGAQLGFNIRGGKASQL---------GIFISKVIPDSDAHRAG-LQEGDQVL 95
R + ++K PG +LG +IRGG GIFISKV P A R G L+ G ++L
Sbjct: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158
Query: 96 AVNDVDFQDIEHSKAVEILKT 116
VN + H +AV++L++
Sbjct: 1159 EVNQQSLLGLTHGEAVQLLRS 1179
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 55.8 bits (133), Expect = 1e-08
Identities = 37/85 (43%), Positives = 50/85 (58%), Gaps = 8/85 (9%)
Query: 47 TITLKKPPGAQLGFNIRGGKAS------QLGIFISKVIPDSDAHRAGLQEGDQVLAVNDV 100
T+T+ + G LG +I GGK S GIFIS+V + A RAG++ GD++L VN V
Sbjct: 728 TLTILRQTGG-LGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGV 786
Query: 101 DFQDIEHSKAVEILKTA-REISMRV 124
Q EH +AVE L+ A + MRV
Sbjct: 787 ALQGAEHHEAVEALRGAGTAVQMRV 811
Score = 55.8 bits (133), Expect = 1e-08
Identities = 34/83 (40%), Positives = 48/83 (57%), Gaps = 9/83 (10%)
Query: 55 GAQLGFNIRGGK--------ASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIE 106
G LG +I GG + G+FISKV+P A R+GL+ GD++LAVN D +D
Sbjct: 1011 GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDAT 1070
Query: 107 HSKAVE-ILKTAREISMRVRFFP 128
H +AV +L+ E+S+ VR P
Sbjct: 1071 HQEAVSALLRPCLELSLLVRRDP 1093
Score = 55.1 bits (131), Expect = 2e-08
Identities = 31/67 (46%), Positives = 40/67 (59%), Gaps = 7/67 (10%)
Query: 58 LGFNIRGGKAS------QLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKA 110
LGF+I GGK S GIF+S++ AHRAG LQ GD+VL++N VD + H A
Sbjct: 872 LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHA 931
Query: 111 VEILKTA 117
V +L A
Sbjct: 932 VSLLTAA 938
Score = 47.8 bits (112), Expect = 3e-06
Identities = 30/81 (37%), Positives = 44/81 (54%), Gaps = 10/81 (12%)
Query: 46 RTITLKKPPGAQLGFNIRGGKASQL---------GIFISKVIPDSDAHRAG-LQEGDQVL 95
R + ++K PG +LG +IRGG GIFISKV P A R G L+ G ++L
Sbjct: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158
Query: 96 AVNDVDFQDIEHSKAVEILKT 116
VN + H +AV++L++
Sbjct: 1159 EVNQQSLLGLTHGEAVQLLRS 1179
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 55.1 bits (131), Expect = 2e-08
Identities = 42/138 (30%), Positives = 68/138 (49%), Gaps = 18/138 (13%)
Query: 6 PYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPP--------GAQ 57
PY Y + LP E + H + H + + L R ++L+ P
Sbjct: 483 PYSHYHLGLLPDSE-----MTSHSQ--HSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG 535
Query: 58 LGFNIRGGKASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILKT 116
LGFNI GG+ + GIF+S ++ A +G LQ GDQ+L+VN +D + H +A LK
Sbjct: 536 LGFNIVGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 594
Query: 117 A-REISMRVRFFPYNYHR 133
A + +++ ++ P +Y R
Sbjct: 595 AGQTVTIIAQYQPEDYAR 612
Score = 53.1 bits (126), Expect = 7e-08
Identities = 37/93 (39%), Positives = 50/93 (53%), Gaps = 7/93 (7%)
Query: 34 PDYNNELTQFLPRTITLKKPPGAQLGFNIRGGK-----ASQLGIFISKVIPDSDAHRAG- 87
P N ++ ITL++ + LGF+I GG GIFI+K+IP A G
Sbjct: 190 PYVNGTEIEYEFEEITLERG-NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGR 248
Query: 88 LQEGDQVLAVNDVDFQDIEHSKAVEILKTAREI 120
L+ D +L VN+VD ++ HSKAVE LK A I
Sbjct: 249 LRVNDCILRVNEVDVSEVSHSKAVEALKEAGSI 281
Score = 47.8 bits (112), Expect = 3e-06
Identities = 29/76 (38%), Positives = 44/76 (57%), Gaps = 8/76 (10%)
Query: 51 KKPPGAQLGFNIRGGKASQL-----GIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQD 104
K P G LGF+I GG +Q I+++K+I A + G LQ GD++L VN+ ++
Sbjct: 303 KGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 360
Query: 105 IEHSKAVEILKTAREI 120
+ H +AV ILK E+
Sbjct: 361 VTHEEAVAILKNTSEV 376
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 55.1 bits (131), Expect = 2e-08
Identities = 42/138 (30%), Positives = 68/138 (49%), Gaps = 18/138 (13%)
Query: 6 PYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPP--------GAQ 57
PY Y + LP E + H + H + + L R ++L+ P
Sbjct: 378 PYSHYHLGLLPDSE-----MTSHSQ--HSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG 430
Query: 58 LGFNIRGGKASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILKT 116
LGFNI GG+ + GIF+S ++ A +G LQ GDQ+L+VN +D + H +A LK
Sbjct: 431 LGFNIVGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 489
Query: 117 A-REISMRVRFFPYNYHR 133
A + +++ ++ P +Y R
Sbjct: 490 AGQTVTIIAQYQPEDYAR 507
Score = 53.1 bits (126), Expect = 7e-08
Identities = 37/93 (39%), Positives = 50/93 (53%), Gaps = 7/93 (7%)
Query: 34 PDYNNELTQFLPRTITLKKPPGAQLGFNIRGGK-----ASQLGIFISKVIPDSDAHRAG- 87
P N ++ ITL++ + LGF+I GG GIFI+K+IP A G
Sbjct: 85 PYVNGTEIEYEFEEITLERG-NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGR 143
Query: 88 LQEGDQVLAVNDVDFQDIEHSKAVEILKTAREI 120
L+ D +L VN+VD ++ HSKAVE LK A I
Sbjct: 144 LRVNDCILRVNEVDVSEVSHSKAVEALKEAGSI 176
Score = 47.8 bits (112), Expect = 3e-06
Identities = 29/76 (38%), Positives = 44/76 (57%), Gaps = 8/76 (10%)
Query: 51 KKPPGAQLGFNIRGGKASQL-----GIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQD 104
K P G LGF+I GG +Q I+++K+I A + G LQ GD++L VN+ ++
Sbjct: 198 KGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 255
Query: 105 IEHSKAVEILKTAREI 120
+ H +AV ILK E+
Sbjct: 256 VTHEEAVAILKNTSEV 271
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 54.7 bits (130), Expect = 2e-08
Identities = 29/72 (40%), Positives = 43/72 (59%), Gaps = 2/72 (2%)
Query: 43 FLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDF 102
+ P T ++ G +G + GG + +GIF+S V S A G+QEGDQ+L VNDV F
Sbjct: 410 YSPDTRVVRFLKGKSIGLRLAGG--NDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPF 467
Query: 103 QDIEHSKAVEIL 114
Q++ +AV+ L
Sbjct: 468 QNLTREEAVQFL 479
Score = 45.1 bits (105), Expect = 2e-05
Identities = 29/84 (34%), Positives = 44/84 (52%), Gaps = 2/84 (2%)
Query: 39 ELTQFLPRTITLKKPPGAQLGFNIRGGKASQLG-IFISKVIPDSDAHRAGLQEGDQVLAV 97
ELT + T TL K P G I GG+ G + +S V+P A LQ GD ++ V
Sbjct: 22 ELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAE-GRLQTGDHIVMV 80
Query: 98 NDVDFQDIEHSKAVEILKTAREIS 121
N V ++ + A++ILKT +++
Sbjct: 81 NGVSMENATSAFAIQILKTCTKMA 104
Score = 27.7 bits (60), Expect = 3.2
Identities = 18/36 (50%), Positives = 22/36 (61%), Gaps = 3/36 (8%)
Query: 72 IFISKVIPDSD--AHRAGLQEGDQVLAVNDVDFQDI 105
IFI K I DS A GLQEGD +L +N V Q++
Sbjct: 233 IFI-KHITDSGLAARHRGLQEGDLILQINGVSSQNL 267
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 54.3 bits (129), Expect = 3e-08
Identities = 34/99 (34%), Positives = 55/99 (55%), Gaps = 9/99 (9%)
Query: 26 PPHERVHHPDYNNELTQFLP---RTITLKKPPGAQLGFNIRGGKASQLG---IFISKVIP 79
PP+ P + +LTQ + + IT+KK P LG + GG+ S+ G IF++ V P
Sbjct: 446 PPY--YSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPP 503
Query: 80 DSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILKTA 117
R G ++ GD +L +N +D ++ HS+AV +LK +
Sbjct: 504 HGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542
Score = 36.2 bits (82), Expect = 0.009
Identities = 24/63 (38%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Query: 54 PGAQLGFNIRGGKASQL-GIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAV 111
P QLG +I GG + L I I +V D R G L GDQ+L VN+ + ++ H+ A
Sbjct: 241 PYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYAR 300
Query: 112 EIL 114
+L
Sbjct: 301 AVL 303
Score = 31.6 bits (70), Expect = 0.22
Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 5/86 (5%)
Query: 48 ITLKKPPGAQLGFNIRGG---KASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQ 103
I L++ GF+I GG + FI ++ + A+ G L+ GD ++AVN +
Sbjct: 601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660
Query: 104 DIEHSKAVEILKTAR-EISMRVRFFP 128
+ HS V +LK R ++++ V +P
Sbjct: 661 GMSHSALVPMLKEQRNKVTLTVICWP 686
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 53.9 bits (128), Expect = 4e-08
Identities = 31/81 (38%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 34 PDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQ 93
P+ +E P +K G +G + GG + +GIF++ V+ DS A + GL+EGDQ
Sbjct: 409 PNSTHEDGILRPSMKLVKFRKGDSVGLRLAGG--NDVGIFVAGVLEDSPAAKEGLEEGDQ 466
Query: 94 VLAVNDVDFQDIEHSKAVEIL 114
+L VN+VDF +I +AV L
Sbjct: 467 ILRVNNVDFTNIIREEAVLFL 487
Score = 43.1 bits (100), Expect = 7e-05
Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 8/86 (9%)
Query: 47 TITLKKPPGAQLGFNIRGGK------ASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDV 100
T+TL + PG G I GG+ + + I IS V+ A LQE D+V VN V
Sbjct: 23 TVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE-GQLQENDRVAMVNGV 81
Query: 101 DFQDIEHSKAVEIL-KTAREISMRVR 125
++EH+ AV+ L K+ + + +R
Sbjct: 82 SMDNVEHAFAVQQLRKSGKNAKITIR 107
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 53.9 bits (128), Expect = 4e-08
Identities = 31/81 (38%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 34 PDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQ 93
P+ +E P +K G +G + GG + +GIF++ V+ DS A + GL+EGDQ
Sbjct: 409 PNSTHEDGILRPSMKLVKFRKGDSVGLRLAGG--NDVGIFVAGVLEDSPAAKEGLEEGDQ 466
Query: 94 VLAVNDVDFQDIEHSKAVEIL 114
+L VN+VDF +I +AV L
Sbjct: 467 ILRVNNVDFTNIIREEAVLFL 487
Score = 43.1 bits (100), Expect = 7e-05
Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 8/86 (9%)
Query: 47 TITLKKPPGAQLGFNIRGGK------ASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDV 100
T+TL + PG G I GG+ + + I IS V+ A LQE D+V VN V
Sbjct: 23 TVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE-GQLQENDRVAMVNGV 81
Query: 101 DFQDIEHSKAVEIL-KTAREISMRVR 125
++EH+ AV+ L K+ + + +R
Sbjct: 82 SMDNVEHAFAVQQLRKSGKNAKITIR 107
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 53.9 bits (128), Expect = 4e-08
Identities = 43/126 (34%), Positives = 61/126 (48%), Gaps = 8/126 (6%)
Query: 2 DSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDY-NNELTQFLPRTITLKKPPGAQLGF 60
D P ++ LP N P I + + P Y N + ITL++ + LGF
Sbjct: 16 DEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERG-NSGLGF 74
Query: 61 NIRGGK-----ASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEIL 114
+I GG IFI+K+IP A + G L+ D +L VN+VD +++ HS AVE L
Sbjct: 75 SIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL 134
Query: 115 KTAREI 120
K A I
Sbjct: 135 KEAGSI 140
Score = 53.1 bits (126), Expect = 7e-08
Identities = 42/128 (32%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 9 DYPVVFLPAYENPPAWIP-PHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKA 67
DYP P +P + P + + D E PR I + + LGFNI GG+
Sbjct: 278 DYPTAMTPT--SPRRYSPVAKDLLGEEDIPRE-----PRRIVIHRG-STGLGFNIVGGED 329
Query: 68 SQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILKTA-REISMRVR 125
+ GIFIS ++ A +G L++GDQ+L+VN VD ++ H +A LK A + +++ +
Sbjct: 330 GE-GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388
Query: 126 FFPYNYHR 133
+ P Y R
Sbjct: 389 YKPEEYSR 396
Score = 52.0 bits (123), Expect = 2e-07
Identities = 31/77 (40%), Positives = 45/77 (58%), Gaps = 8/77 (10%)
Query: 50 LKKPPGAQLGFNIRGGKASQL-----GIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQ 103
+K P G LGF+I GG +Q I+++K+I AH+ G LQ GD++LAVN V +
Sbjct: 161 IKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 218
Query: 104 DIEHSKAVEILKTAREI 120
D+ H AV LK ++
Sbjct: 219 DVMHEDAVAALKNTYDV 235
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 53.9 bits (128), Expect = 4e-08
Identities = 44/125 (35%), Positives = 61/125 (48%), Gaps = 10/125 (8%)
Query: 5 IPYDDYPVVFLPAYE--NPPAWIPPHERVHHPDY-NNELTQFLPRTITLKKPPGAQLGFN 61
+P V LP NPP + + + P Y N + ITL++ + LGF+
Sbjct: 179 LPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERG-NSGLGFS 237
Query: 62 IRGGK-----ASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILK 115
I GG IFI+K+I A + G L+ D +L VN+VD +D+ HSKAVE LK
Sbjct: 238 IAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK 297
Query: 116 TAREI 120
A I
Sbjct: 298 EAGSI 302
Score = 51.6 bits (122), Expect = 2e-07
Identities = 43/132 (32%), Positives = 70/132 (53%), Gaps = 9/132 (6%)
Query: 6 PYDDY--PVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIR 63
P D++ P FL PA P + D +E+T+ PR + L + LGFNI
Sbjct: 426 PVDNHVSPSSFLGQTPASPARYSPVSKAVLGD--DEITRE-PRKVVLHRG-STGLGFNIV 481
Query: 64 GGKASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILKTA-REIS 121
GG+ + GIFIS ++ A +G L++GD++++VN VD + H +A LK A + ++
Sbjct: 482 GGEDGE-GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540
Query: 122 MRVRFFPYNYHR 133
+ ++ P Y R
Sbjct: 541 IVAQYRPEEYSR 552
Score = 49.7 bits (117), Expect = 8e-07
Identities = 30/76 (39%), Positives = 46/76 (60%), Gaps = 8/76 (10%)
Query: 50 LKKPPGAQLGFNIRGGKASQL-----GIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQ 103
+K P G LGF+I GG +Q I+++K+I AH+ G LQ GD++LAVN+V +
Sbjct: 323 IKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380
Query: 104 DIEHSKAVEILKTARE 119
++ H +AV LK +
Sbjct: 381 EVTHEEAVTALKNTSD 396
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 53.9 bits (128), Expect = 4e-08
Identities = 44/125 (35%), Positives = 61/125 (48%), Gaps = 10/125 (8%)
Query: 5 IPYDDYPVVFLPAYE--NPPAWIPPHERVHHPDY-NNELTQFLPRTITLKKPPGAQLGFN 61
+P V LP NPP + + + P Y N + ITL++ + LGF+
Sbjct: 179 LPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERG-NSGLGFS 237
Query: 62 IRGGK-----ASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILK 115
I GG IFI+K+I A + G L+ D +L VN+VD +D+ HSKAVE LK
Sbjct: 238 IAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK 297
Query: 116 TAREI 120
A I
Sbjct: 298 EAGSI 302
Score = 51.6 bits (122), Expect = 2e-07
Identities = 43/132 (32%), Positives = 70/132 (53%), Gaps = 9/132 (6%)
Query: 6 PYDDY--PVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIR 63
P D++ P FL PA P + D +E+T+ PR + L + LGFNI
Sbjct: 426 PVDNHVSPSSFLGQTPASPARYSPVSKAVLGD--DEITRE-PRKVVLHRG-STGLGFNIV 481
Query: 64 GGKASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILKTA-REIS 121
GG+ + GIFIS ++ A +G L++GD++++VN VD + H +A LK A + ++
Sbjct: 482 GGEDGE-GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540
Query: 122 MRVRFFPYNYHR 133
+ ++ P Y R
Sbjct: 541 IVAQYRPEEYSR 552
Score = 49.7 bits (117), Expect = 8e-07
Identities = 30/76 (39%), Positives = 46/76 (60%), Gaps = 8/76 (10%)
Query: 50 LKKPPGAQLGFNIRGGKASQL-----GIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQ 103
+K P G LGF+I GG +Q I+++K+I AH+ G LQ GD++LAVN+V +
Sbjct: 323 IKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380
Query: 104 DIEHSKAVEILKTARE 119
++ H +AV LK +
Sbjct: 381 EVTHEEAVTALKNTSD 396
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 53.9 bits (128), Expect = 4e-08
Identities = 34/91 (37%), Positives = 53/91 (58%), Gaps = 4/91 (4%)
Query: 45 PRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQ 103
PR + L K LGFNI GG+ + GIF+S ++ A +G LQ GDQ+L+VN +D +
Sbjct: 316 PRKVVLHKG-STGLGFNIVGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 373
Query: 104 DIEHSKAVEILKTA-REISMRVRFFPYNYHR 133
H +A LK A + +++ ++ P +Y R
Sbjct: 374 GASHEQAAAALKGAGQTVTIIAQYQPEDYAR 404
Score = 52.8 bits (125), Expect = 9e-08
Identities = 35/79 (44%), Positives = 46/79 (58%), Gaps = 7/79 (8%)
Query: 48 ITLKKPPGAQLGFNIRGGK-----ASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVD 101
ITL++ + LGF+I GG GIFI+K+IP A G L+ D +L VN+VD
Sbjct: 48 ITLERG-NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106
Query: 102 FQDIEHSKAVEILKTAREI 120
++ HSKAVE LK A I
Sbjct: 107 VSEVSHSKAVEALKEAGSI 125
Score = 47.8 bits (112), Expect = 3e-06
Identities = 29/76 (38%), Positives = 44/76 (57%), Gaps = 8/76 (10%)
Query: 51 KKPPGAQLGFNIRGGKASQL-----GIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQD 104
K P G LGF+I GG +Q I+++K+I A + G LQ GD++L VN+ ++
Sbjct: 147 KGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 204
Query: 105 IEHSKAVEILKTAREI 120
+ H +AV ILK E+
Sbjct: 205 VTHEEAVAILKNTSEV 220
>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
Length = 540
Score = 53.9 bits (128), Expect = 4e-08
Identities = 29/83 (34%), Positives = 50/83 (60%), Gaps = 2/83 (2%)
Query: 46 RTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRA-GLQEGDQVLAVNDVDFQD 104
R + + K LG +I+GG+ +++ I ISK+ P A ++ L+ GD +L+VN D +
Sbjct: 114 RRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQ 173
Query: 105 IEHSKAVEILKTA-REISMRVRF 126
H +AV+ LK A +E+ + V+F
Sbjct: 174 ATHDQAVQALKRAGKEVLLEVKF 196
>gi|9507165 syntrophin, gamma 2 [Homo sapiens]
Length = 539
Score = 53.5 bits (127), Expect = 5e-08
Identities = 29/83 (34%), Positives = 48/83 (57%), Gaps = 2/83 (2%)
Query: 46 RTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQD 104
RT+TL++ P LG +I+GG + + ISK+ D A + G L GD VL VN + ++
Sbjct: 72 RTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVEN 131
Query: 105 IEHSKAVEILKTA-REISMRVRF 126
H + V +L+ A E+++ V +
Sbjct: 132 ATHEEVVHLLRNAGDEVTITVEY 154
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 53.1 bits (126), Expect = 7e-08
Identities = 42/128 (32%), Positives = 66/128 (51%), Gaps = 12/128 (9%)
Query: 9 DYPVVFLPAYENPPAWIP-PHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKA 67
DYP P +P + P + + D E PR I + + LGFNI GG+
Sbjct: 324 DYPTAMTPT--SPRRYSPVAKDLLGEEDIPRE-----PRRIVIHRG-STGLGFNIVGGED 375
Query: 68 SQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILKTA-REISMRVR 125
+ GIFIS ++ A +G L++GDQ+L+VN VD ++ H +A LK A + +++ +
Sbjct: 376 GE-GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
Query: 126 FFPYNYHR 133
+ P Y R
Sbjct: 435 YKPEEYSR 442
Score = 52.8 bits (125), Expect = 9e-08
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 11/129 (8%)
Query: 2 DSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELT----QFLPRTITLKKPPGAQ 57
D P ++ LP N P I + + P Y ++ + ITL++ +
Sbjct: 59 DEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERG-NSG 117
Query: 58 LGFNIRGGK-----ASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAV 111
LGF+I GG IFI+K+IP A + G L+ D +L VN+VD +++ HS AV
Sbjct: 118 LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAV 177
Query: 112 EILKTAREI 120
E LK A I
Sbjct: 178 EALKEAGSI 186
Score = 52.0 bits (123), Expect = 2e-07
Identities = 31/77 (40%), Positives = 45/77 (58%), Gaps = 8/77 (10%)
Query: 50 LKKPPGAQLGFNIRGGKASQL-----GIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQ 103
+K P G LGF+I GG +Q I+++K+I AH+ G LQ GD++LAVN V +
Sbjct: 207 IKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 264
Query: 104 DIEHSKAVEILKTAREI 120
D+ H AV LK ++
Sbjct: 265 DVMHEDAVAALKNTYDV 281
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 53.1 bits (126), Expect = 7e-08
Identities = 31/83 (37%), Positives = 46/83 (55%), Gaps = 10/83 (12%)
Query: 45 PRTITLKKPPGAQLGFNIRGGKA---------SQLGIFISKVIPDSDAHRAG-LQEGDQV 94
PR + + + P LG +I GG+ GIFI +V+ DS A + L+ GD++
Sbjct: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 95 LAVNDVDFQDIEHSKAVEILKTA 117
L V+ VD Q+ HS+AVE +K A
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNA 1148
Score = 49.7 bits (117), Expect = 8e-07
Identities = 29/93 (31%), Positives = 47/93 (50%), Gaps = 4/93 (4%)
Query: 29 ERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLG---IFISKVIPDSDAHR 85
+RV P N T PRT+ + + LG +I GG+ S LG +FI+ + A R
Sbjct: 1658 KRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAAR 1717
Query: 86 A-GLQEGDQVLAVNDVDFQDIEHSKAVEILKTA 117
L+ GD+++++N + H+ V +LK A
Sbjct: 1718 TQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
Score = 42.7 bits (99), Expect = 1e-04
Identities = 31/101 (30%), Positives = 53/101 (52%), Gaps = 12/101 (11%)
Query: 24 WIPPHERVHHPDYNNELTQFLP----RTITLKKPPGAQLGFNIRGGKASQLG---IFISK 76
W P ++ + D+N+ + Q I +++P LGF++ ++ LG IF+
Sbjct: 110 WTP---KLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKD 166
Query: 77 VIPDSDAHR-AGLQEGDQVLAVNDVDF-QDIEHSKAVEILK 115
V P S A R L+E DQ+LA+N Q+I H +A+ +L+
Sbjct: 167 VQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQ 207
Score = 41.6 bits (96), Expect = 2e-04
Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 29 ERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAG- 87
+ H+ D N + P + L+K G LG +I G K + G+FIS ++ A G
Sbjct: 1519 DEAHYRDEEN--LEIFP--VDLQKKAGRGLGLSIVG-KRNGSGVFISDIVKGGAADLDGR 1573
Query: 88 LQEGDQVLAVNDVDFQDIEHSKAVEILKTAR 118
L +GDQ+L+VN D ++ ILK A+
Sbjct: 1574 LIQGDQILSVNGEDMRNASQETVATILKCAQ 1604
Score = 41.2 bits (95), Expect = 3e-04
Identities = 26/81 (32%), Positives = 43/81 (53%), Gaps = 10/81 (12%)
Query: 48 ITLKKPPGAQLGFNIRG-------GKASQLGIFISKVIPDSDA-HRAGLQEGDQVLAVND 99
+ L + G LG I G G+AS GI++ +IP S A H +Q D+++AV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEAS--GIYVKSIIPGSAAYHNGHIQVNDKIVAVDG 423
Query: 100 VDFQDIEHSKAVEILKTAREI 120
V+ Q + VE+L+ A ++
Sbjct: 424 VNIQGFANHDVVEVLRNAGQV 444
Score = 41.2 bits (95), Expect = 3e-04
Identities = 31/84 (36%), Positives = 45/84 (53%), Gaps = 8/84 (9%)
Query: 58 LGFNIRGGKASQLG-IFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILK 115
LG +I GGK + L I I +V + A R G L GDQ+L VN VD ++ H +A+ L
Sbjct: 1447 LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL- 1505
Query: 116 TAREISMRVRFFPYN---YHRQKE 136
R+ +VR Y ++R +E
Sbjct: 1506 --RQTPQKVRLVVYRDEAHYRDEE 1527
Score = 39.3 bits (90), Expect = 0.001
Identities = 21/62 (33%), Positives = 34/62 (54%), Gaps = 3/62 (4%)
Query: 55 GAQLGFNIRGGKASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEI 113
G+ LGF I GGK S G+ + ++P A R G LQ GD +L + + Q + + ++
Sbjct: 255 GSGLGFGIVGGKTS--GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQV 312
Query: 114 LK 115
L+
Sbjct: 313 LR 314
Score = 33.1 bits (74), Expect = 0.076
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 2/62 (3%)
Query: 58 LGFNIRGGK-ASQLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILK 115
LG ++ G K S++ IF+ + P+ A G ++ GD++L +N+ H A I+K
Sbjct: 1249 LGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIK 1308
Query: 116 TA 117
TA
Sbjct: 1309 TA 1310
Score = 30.0 bits (66), Expect = 0.65
Identities = 17/45 (37%), Positives = 28/45 (62%), Gaps = 1/45 (2%)
Query: 72 IFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILK 115
I I ++ D A R+G L GD++++VN+ + ++AVEILK
Sbjct: 714 IVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758
>gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
Length = 505
Score = 53.1 bits (126), Expect = 7e-08
Identities = 28/83 (33%), Positives = 49/83 (59%), Gaps = 2/83 (2%)
Query: 46 RTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRA-GLQEGDQVLAVNDVDFQD 104
R +T++K LG +I+GG+ +++ I ISK+ A + L GD +L+VN D
Sbjct: 86 RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
Query: 105 IEHSKAVEIL-KTAREISMRVRF 126
H +AV++L KT +E+ + V++
Sbjct: 146 ATHDEAVQVLKKTGKEVVLEVKY 168
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 52.8 bits (125), Expect = 9e-08
Identities = 32/76 (42%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 48 ITLKKPPGAQLGFNIRGGKAS---QLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQ 103
+ LKK LGF I GG+ LGIFIS V P A G L+ GD++++VN V +
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 104 DIEHSKAVEILKTARE 119
+ H A+EIL+ A E
Sbjct: 1154 GVSHHAAIEILQNAPE 1169
Score = 46.2 bits (108), Expect = 9e-06
Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 4/86 (4%)
Query: 35 DYNNELTQF---LPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEG 91
D N L F + ITL K LGF + G ++G ++ VI D L+ G
Sbjct: 1778 DLENHLEDFELEVELLITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDPAKSDGRLKPG 1836
Query: 92 DQVLAVNDVDFQDIEHSKAVEILKTA 117
D+++ VND D ++ H+ AV +L+ A
Sbjct: 1837 DRLIKVNDTDVTNMTHTDAVNLLRAA 1862
Score = 40.4 bits (93), Expect = 5e-04
Identities = 20/51 (39%), Positives = 30/51 (58%), Gaps = 1/51 (1%)
Query: 71 GIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEILKTAREI 120
GI++ VIP A G + +GD+VLAVN V + H +AVE L+ ++
Sbjct: 1399 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQV 1449
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 52.8 bits (125), Expect = 9e-08
Identities = 32/76 (42%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 48 ITLKKPPGAQLGFNIRGGKAS---QLGIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQ 103
+ LKK LGF I GG+ LGIFIS V P A G L+ GD++++VN V +
Sbjct: 903 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 962
Query: 104 DIEHSKAVEILKTARE 119
+ H A+EIL+ A E
Sbjct: 963 GVSHHAAIEILQNAPE 978
Score = 46.2 bits (108), Expect = 9e-06
Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 4/86 (4%)
Query: 35 DYNNELTQF---LPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEG 91
D N L F + ITL K LGF + G ++G ++ VI D L+ G
Sbjct: 1582 DLENHLEDFELEVELLITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDPAKSDGRLKPG 1640
Query: 92 DQVLAVNDVDFQDIEHSKAVEILKTA 117
D+++ VND D ++ H+ AV +L+ A
Sbjct: 1641 DRLIKVNDTDVTNMTHTDAVNLLRAA 1666
Score = 43.9 bits (102), Expect = 4e-05
Identities = 24/67 (35%), Positives = 38/67 (56%), Gaps = 4/67 (5%)
Query: 58 LGFNIRGGKASQL---GIFISKVIPDSDAHRAG-LQEGDQVLAVNDVDFQDIEHSKAVEI 113
LG ++ GG + + GI++ VIP A G + +GD+VLAVN V + H +AVE
Sbjct: 1187 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1246
Query: 114 LKTAREI 120
L+ ++
Sbjct: 1247 LRNTGQV 1253
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.139 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,995,364
Number of Sequences: 37866
Number of extensions: 256451
Number of successful extensions: 952
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 138
Number of HSP's successfully gapped in prelim test: 56
Number of HSP's that attempted gapping in prelim test: 631
Number of HSP's gapped (non-prelim): 319
length of query: 140
length of database: 18,247,518
effective HSP length: 92
effective length of query: 48
effective length of database: 14,763,846
effective search space: 708664608
effective search space used: 708664608
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 56 (26.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.