Search of human proteins with 7656967

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
         (3014 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s...  6149   0.0  
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ...  3325   0.0  
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo...  2815   0.0  
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]            574   e-163
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]            460   e-128
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]           453   e-126
gi|16933557 dachsous 1 precursor [Homo sapiens]                       414   e-115
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]      413   e-114
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]           362   2e-99
gi|47059046 dachsous 2 isoform 1 [Homo sapiens]                       360   2e-98
gi|216548385 dachsous 2 isoform 2 [Homo sapiens]                      326   2e-88
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]        291   9e-78
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]        291   9e-78
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]         288   4e-77
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]        288   4e-77
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]        284   8e-76
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]        284   8e-76
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]        284   8e-76
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s...   281   9e-75
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]        281   9e-75
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]        281   9e-75
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ...   281   9e-75
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi...   268   6e-71
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap...   268   6e-71
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi...   268   6e-71
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi...   268   6e-71
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi...   268   6e-71
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi...   268   6e-71
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi...   268   6e-71
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi...   268   6e-71

>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
            sapiens]
          Length = 3014

 Score = 6149 bits (15953), Expect = 0.0
 Identities = 3014/3014 (100%), Positives = 3014/3014 (100%)

Query: 1    MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRA 60
            MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRA
Sbjct: 1    MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRA 60

Query: 61   PRELLDVGRDGRLAGRRRVSGAGRPLPLQVRLVARSAPTALSRRLRARTHLPGCGARARL 120
            PRELLDVGRDGRLAGRRRVSGAGRPLPLQVRLVARSAPTALSRRLRARTHLPGCGARARL
Sbjct: 61   PRELLDVGRDGRLAGRRRVSGAGRPLPLQVRLVARSAPTALSRRLRARTHLPGCGARARL 120

Query: 121  CGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVR 180
            CGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVR
Sbjct: 121  CGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVR 180

Query: 181  LRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGR 240
            LRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGR
Sbjct: 181  LRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGR 240

Query: 241  GSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDS 300
            GSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDS
Sbjct: 241  GSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDS 300

Query: 301  ATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE 360
            ATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE
Sbjct: 301  ATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE 360

Query: 361  RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEA 420
            RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEA
Sbjct: 361  RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEA 420

Query: 421  AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480
            AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR
Sbjct: 421  AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480

Query: 481  VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG 540
            VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG
Sbjct: 481  VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG 540

Query: 541  RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARL 600
            RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARL
Sbjct: 541  RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARL 600

Query: 601  HYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAV 660
            HYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAV
Sbjct: 601  HYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAV 660

Query: 661  DHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVI 720
            DHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVI
Sbjct: 661  DHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVI 720

Query: 721  TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVT 780
            TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVT
Sbjct: 721  TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVT 780

Query: 781  DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPD 840
            DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPD
Sbjct: 781  DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPD 840

Query: 841  SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS 900
            SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS
Sbjct: 841  SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS 900

Query: 901  IFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDREN 960
            IFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDREN
Sbjct: 901  IFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDREN 960

Query: 961  VAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAK 1020
            VAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAK
Sbjct: 961  VAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAK 1020

Query: 1021 IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP 1080
            IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP
Sbjct: 1021 IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP 1080

Query: 1081 LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNY 1140
            LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNY
Sbjct: 1081 LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNY 1140

Query: 1141 TFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITD 1200
            TFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITD
Sbjct: 1141 TFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITD 1200

Query: 1201 DMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNV 1260
            DMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNV
Sbjct: 1201 DMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNV 1260

Query: 1261 TFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVS 1320
            TFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVS
Sbjct: 1261 TFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVS 1320

Query: 1321 VLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRS 1380
            VLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRS
Sbjct: 1321 VLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRS 1380

Query: 1381 REGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYC 1440
            REGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYC
Sbjct: 1381 REGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYC 1440

Query: 1441 EVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQ 1500
            EVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQ
Sbjct: 1441 EVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQ 1500

Query: 1501 VQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVD 1560
            VQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVD
Sbjct: 1501 VQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVD 1560

Query: 1561 DCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGC 1620
            DCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGC
Sbjct: 1561 DCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGC 1620

Query: 1621 MRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFG 1680
            MRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFG
Sbjct: 1621 MRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFG 1680

Query: 1681 GKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFR 1740
            GKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFR
Sbjct: 1681 GKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFR 1740

Query: 1741 LQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDY 1800
            LQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDY
Sbjct: 1741 LQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDY 1800

Query: 1801 GMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMNN 1860
            GMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMNN
Sbjct: 1801 GMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMNN 1860

Query: 1861 ALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMG 1920
            ALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMG
Sbjct: 1861 ALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMG 1920

Query: 1921 ACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHCAVSKGFDPDCNK 1980
            ACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHCAVSKGFDPDCNK
Sbjct: 1921 ACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHCAVSKGFDPDCNK 1980

Query: 1981 TNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGVIGRQCNRCDNPF 2040
            TNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGVIGRQCNRCDNPF
Sbjct: 1981 TNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGVIGRQCNRCDNPF 2040

Query: 2041 AEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCSGEKGWLPPE 2100
            AEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCSGEKGWLPPE
Sbjct: 2041 AEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCSGEKGWLPPE 2100

Query: 2101 LFNCTTISFVDLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTLFGNDVRTAYQLL 2160
            LFNCTTISFVDLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTLFGNDVRTAYQLL
Sbjct: 2101 LFNCTTISFVDLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTLFGNDVRTAYQLL 2160

Query: 2161 GHVLQHESWQQGFDLAATQDADFHEDVIHSGSALLAPATRAAWEQIQRSEGGTAQLLRRL 2220
            GHVLQHESWQQGFDLAATQDADFHEDVIHSGSALLAPATRAAWEQIQRSEGGTAQLLRRL
Sbjct: 2161 GHVLQHESWQQGFDLAATQDADFHEDVIHSGSALLAPATRAAWEQIQRSEGGTAQLLRRL 2220

Query: 2221 EGYFSNVARNVRRTYLRPFVIVTANMILAVDIFDKFNFTGARVPRFDTIHEEFPRELESS 2280
            EGYFSNVARNVRRTYLRPFVIVTANMILAVDIFDKFNFTGARVPRFDTIHEEFPRELESS
Sbjct: 2221 EGYFSNVARNVRRTYLRPFVIVTANMILAVDIFDKFNFTGARVPRFDTIHEEFPRELESS 2280

Query: 2281 VSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTEREAPISRRRRHPDDAGQFAVAL 2340
            VSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTEREAPISRRRRHPDDAGQFAVAL
Sbjct: 2281 VSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTEREAPISRRRRHPDDAGQFAVAL 2340

Query: 2341 VIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFAL 2400
            VIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFAL
Sbjct: 2341 VIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFAL 2400

Query: 2401 LEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNRTHVACQCSHTASFAVLMDISRR 2460
            LEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNRTHVACQCSHTASFAVLMDISRR
Sbjct: 2401 LEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNRTHVACQCSHTASFAVLMDISRR 2460

Query: 2461 ENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLSQLVFVI 2520
            ENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLSQLVFVI
Sbjct: 2461 ENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLSQLVFVI 2520

Query: 2521 GINQTENPFLCTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWG 2580
            GINQTENPFLCTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWG
Sbjct: 2521 GINQTENPFLCTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWG 2580

Query: 2581 IPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPIGAVIIINTVTSVLSAKVSCQR 2640
            IPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPIGAVIIINTVTSVLSAKVSCQR
Sbjct: 2581 IPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPIGAVIIINTVTSVLSAKVSCQR 2640

Query: 2641 KHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVNRDALSFHYLFAIFSGLQGPFVLLF 2700
            KHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVNRDALSFHYLFAIFSGLQGPFVLLF
Sbjct: 2641 KHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVNRDALSFHYLFAIFSGLQGPFVLLF 2700

Query: 2701 HCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTA 2760
            HCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTA
Sbjct: 2701 HCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTA 2760

Query: 2761 SLDSIVRDEGIQKLGVSSGLVRGSHGEPDASLMPRSCKDPPGHDSDSDSELSLDEQSSSY 2820
            SLDSIVRDEGIQKLGVSSGLVRGSHGEPDASLMPRSCKDPPGHDSDSDSELSLDEQSSSY
Sbjct: 2761 SLDSIVRDEGIQKLGVSSGLVRGSHGEPDASLMPRSCKDPPGHDSDSDSELSLDEQSSSY 2820

Query: 2821 ASSHSSDSEDDGVGAEEKWDPARGAVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKP 2880
            ASSHSSDSEDDGVGAEEKWDPARGAVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKP
Sbjct: 2821 ASSHSSDSEDDGVGAEEKWDPARGAVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKP 2880

Query: 2881 RLKVETKVSVELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLT 2940
            RLKVETKVSVELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLT
Sbjct: 2881 RLKVETKVSVELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLT 2940

Query: 2941 LTEQTLKGRLREKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGVAMNVR 3000
            LTEQTLKGRLREKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGVAMNVR
Sbjct: 2941 LTEQTLKGRLREKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGVAMNVR 3000

Query: 3001 TGSAQADGSDSEKP 3014
            TGSAQADGSDSEKP
Sbjct: 3001 TGSAQADGSDSEKP 3014


>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
            sapiens]
          Length = 2923

 Score = 3325 bits (8622), Expect = 0.0
 Identities = 1659/2825 (58%), Positives = 2068/2825 (73%), Gaps = 107/2825 (3%)

Query: 223  PEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSY 282
            PE   G  R+    T+ +    F  P+YQ  + EN+PAGT +  L A    EGE  R+ Y
Sbjct: 163  PEESLGGRRKRNVNTAPQ----FQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEY 218

Query: 283  YMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVL 342
             M+ LFD RS  +F +D  TGAV+T   LDRETK THV RV A D+  P RSA   +T+L
Sbjct: 219  TMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTIL 278

Query: 343  VKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAW----D 398
            V DTNDH PVFEQ EY+E +RENLEVGYEVLT+RA+D D+P NAN+ YR+L G+     +
Sbjct: 279  VTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSE 338

Query: 399  VFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQ 458
            VF+++  SGV+ TR  +DREE   YQL VEA+DQGR+PGP S TA V++ VED+NDN PQ
Sbjct: 339  VFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQ 398

Query: 459  FSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDV 518
            FSE+ YVVQV EDV     VLRV A+DRD+G NA +HYSI+SGN  GQFYL + +G LDV
Sbjct: 399  FSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDV 458

Query: 519  INPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENV 578
            ++PLD+E  ++Y+L ++AQDGGRPPL N SG+V+VQVLD+NDN PIFVS+PFQATVLE+V
Sbjct: 459  VSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESV 518

Query: 579  PLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGW 638
            PLGY V+H+QA+DAD+G+NARL YRL                      DFPF I+N +GW
Sbjct: 519  PLGYLVLHVQAIDADAGDNARLEYRLAGVGH-----------------DFPFTINNGTGW 561

Query: 639  ITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNE 698
            I+V AELDREEV+ YSFGVEA DHG+P +++S SVS+TVLDVNDN+P FTQP Y +RLNE
Sbjct: 562  ISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNE 621

Query: 699  DAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQY 758
            DAAVG+SV+T+ A DRDA+SVITYQ+T GNTRNRF+++SQ GGGL++LALPLDYK E+QY
Sbjct: 622  DAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQY 681

Query: 759  VLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDT 818
            VLAVTASDGTR  TA +++NVTDANTHRPVFQSSHYTV+V+EDRP GT++  +SA DEDT
Sbjct: 682  VLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDT 741

Query: 819  GENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTL 878
            GENARITY ++D +PQFRID D+G + T  ELDYE+QV+YTL I A+DNGIPQKSDTT L
Sbjct: 742  GENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYL 801

Query: 879  EILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGD 938
            EIL+ D NDNAPQFL D YQGS++ED PP TS+LQ+SATDRDSG NGR+ YTFQGGDDGD
Sbjct: 802  EILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGD 861

Query: 939  GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPM 998
            GDF +E TSG++RT RRLDRENVA Y L A AVD+G P P    +E+ VT+LD+NDN P+
Sbjct: 862  GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMP-PARTPMEVTVTVLDVNDNPPV 920

Query: 999  FEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRA 1058
            FE+DE ++FVEEN+P+G  VA++ A DPDEG NAQIMYQIVEG++   FQLD+ +G+L A
Sbjct: 921  FEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTA 980

Query: 1059 MVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNS 1118
            +V+LD+E R EYVLV+QATSAPLVSRATVH+ L+D+NDNPPVL +F+ILFNNYVTN+S+S
Sbjct: 981  LVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSS 1040

Query: 1119 FPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEV 1178
            FP G IG +PAHDPD+SDSL Y+F +GNEL L+LL+ +TGEL+LSR LDNNRPLEA+M V
Sbjct: 1041 FPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSV 1100

Query: 1179 SVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTT 1238
             VSDG+HSVTA C LRVTIITD+MLT+SIT+RLE+MS E+FLSPLL LF++ VAA L+T 
Sbjct: 1101 LVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATP 1160

Query: 1239 KDDVFVFNVQNDTDV-SSNILNVTFSALLPGGVRG--QFFPSEDLQEQIYLNRTLLTTIS 1295
             D V VFNVQ DTD    +ILNV+ S   P G  G   F PSEDLQE++YLNR+LLT IS
Sbjct: 1161 PDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLTAIS 1220

Query: 1296 TQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGF 1355
             QRVLPFDDNICLREPCENYM+CVSVLRFDSSAPF++S++VLFRPIHP+ GLRCRCPPGF
Sbjct: 1221 AQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGF 1280

Query: 1356 TGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNG 1415
            TGDYCETE+DLCYS PCG +GRCRSREGGYTC C + +TGEHCEV ARSGRC  GVCKNG
Sbjct: 1281 TGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNG 1340

Query: 1416 GTCVNLLIGGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQER 1475
            GTCVNLL+GGF C CP G++E+PYC+VTTRSFP  SF+TFRGLRQRFHFT++L+FAT+ER
Sbjct: 1341 GTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKER 1400

Query: 1476 NGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYY 1535
            +GLLLYNGRFNEKHDF+ALE++ EQVQLTFSAGE+TTTV+P VP GVSDG+WH+VQ++YY
Sbjct: 1401 DGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYY 1460

Query: 1536 NKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLT 1595
            NKP +G  GLP GPS +K+AVVTVD CDT +A+RFG  +GNYSCAAQGTQ GSKKSLDLT
Sbjct: 1461 NKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLT 1520

Query: 1596 GPLLLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDG 1655
            GPLLLGGVP+LPE FPV  RQFVGCMRNL VD +++DMA FIANNGT  GC A++N CD 
Sbjct: 1521 GPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDS 1580

Query: 1656 RRCQNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYL 1715
              C NGGTCVN+W+ + CECPL FGGK+C Q M +PQ F G S+V+W  L++ IS PWYL
Sbjct: 1581 NTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWYL 1640

Query: 1716 GLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWH 1775
             LMFRTR+ D VL++A + G ++  LQ+   ++   V        S+ L   R  DG+WH
Sbjct: 1641 SLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWH 1700

Query: 1776 HLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRR 1835
            H  + L          H + ++ DYG  + + ++G  L GL + ++ VGG       V R
Sbjct: 1701 HAQLAL---GASGGPGHAI-LSFDYGQQRAEGNLGPRLHGLHLSNITVGGIPGPAGGVAR 1756

Query: 1836 GFRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYS 1895
            GFRGC+QGVR+  TP  V +L+ ++   + V+ GC + DPC S+PCP NS C + W+ YS
Sbjct: 1757 GFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYS 1816

Query: 1896 CVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPR 1955
            C CD GY G NC + C LNPCE+   C R P +P GY CEC P++ GPYCE ++D PCPR
Sbjct: 1817 CSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYLGPYCETRIDQPCPR 1876

Query: 1956 GWWGNPVCGPCHCAVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTC 2015
            GWWG+P CGPC+C VSKGFDPDCNKT+G+C CKEN+Y+     TCL CDC+P GS SR C
Sbjct: 1877 GWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVC 1936

Query: 2016 DMATGQCACKPGVIGRQCNRCDNPFAEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAA 2075
            D   GQC CKPGVIGRQC+RCDNPFAEVTT GCEV Y+ CP+A EAGIWWP+T+FG PAA
Sbjct: 1937 DPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAA 1996

Query: 2076 VPCPKGSVGNAVRHCSGEKGWLPPELFNCTTISFVDLRAMNEKLSRNETQVDGARALQLV 2135
             PCPKGS G AVRHC   +GWLPP LFNCT+I+F +L+   E+L RNE+ +D  R+ QL 
Sbjct: 1997 APCPKGSFGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQLA 2056

Query: 2136 RALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIHSGSALL 2195
              LR+ATQHT   FG+DV+ AYQL   +L HES Q+GF L+ATQD  F E+++  GSALL
Sbjct: 2057 LLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSALL 2116

Query: 2196 APATRAAWEQIQRSEGGTAQLLRRLEGYFSNVARNVRRTYLRPFVIVTANMILAVDIFDK 2255
              A +  WE IQ++EGGTA LL+  E Y S +A+N+R TYL PF IVT N++++V   DK
Sbjct: 2117 DTANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDK 2176

Query: 2256 FNFTGARVPRFDTIHEEFPRELESSVSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGP 2315
             NF GA++PR++ +  E P +LE++V  P   FR    +  P++RPAG         PG 
Sbjct: 2177 GNFAGAKLPRYEALRGEQPPDLETTVILPESVFR----ETPPVVRPAG---------PGE 2223

Query: 2316 GTEREAPISRRRRHPDDAGQFAVALVIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMV 2375
              E E    R+RRHP+ +   AVA VIIYRTL  LLP  YDPD+RSLR+P RPIINTP+V
Sbjct: 2224 AQEPEELARRQRRHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINTPVV 2283

Query: 2376 STLVYSEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLS 2435
            S  V+ +   LPR L++PV V+F LLE EERTKP+CVFWNHS+ V GTGGWSARGCE++ 
Sbjct: 2284 SISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVF 2343

Query: 2436 RNRTHVACQCSHTASFAVLMDISRRENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRM 2495
            RN +HV+CQC+H  SFAVLMD+SRRENGE+LPLK +TY A+ ++LAALL+ F  L+L+R+
Sbjct: 2344 RNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTLLRI 2403

Query: 2496 LRSNLHSIHKHLAVALFLSQLVFVIGINQTENPFLCTVVAILLHYIYMSTFAWTLVESLH 2555
            LRSN H I ++L  AL L+QLVF++GINQ + PF CTV+AILLH++Y+ TF+W L+E+LH
Sbjct: 2404 LRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALH 2463

Query: 2556 VYRMLTEVRNIDTGPMRFYYVVGWGIPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSF 2615
            +YR LTEVR+++TGPMRFYY++GWG+PA +TGLAVGLDP+GYGNPDFCWLS+ DTLIWSF
Sbjct: 2464 LYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSF 2523

Query: 2616 AGPIGAVIIINTVTSVLSAKVSCQRKHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAV 2675
            AGP+   + ++    +L+A+ SC  +   + KKG VS L+ +F +LLL+SATWLL LL+V
Sbjct: 2524 AGPVAFAVSMSVFLYILAARASCAAQRQGFEKKGPVSGLQPSFAVLLLLSATWLLALLSV 2583

Query: 2676 NRDALSFHYLFAIFSGLQGPFVLLFHCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLT 2735
            N D L FHYLFA  + +QGPF+ L + VL++EVRK LK +   RK   + + TT++T LT
Sbjct: 2584 NSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALK-LACSRKPSPDPALTTKST-LT 2641

Query: 2736 RSLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEGIQK------LGVSSGLVRGSH---- 2785
             S NC + + DG   L    G+S  SL S  R    Q       L   S L  G      
Sbjct: 2642 SSYNCPSPYADG--RLYQPYGDSAGSLHSTSRSGKSQPSYIPFLLREESALNPGQGPPGL 2699

Query: 2786 GEPDASLMPRSCKDPPGHDSDSDSELSL-DEQSSSYASSHSSDSEDDGVGAEEK------ 2838
            G+P  SL           D+DSDS+LSL D+QS SYAS+HSSDSE++    EE+      
Sbjct: 2700 GDP-GSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGE 2758

Query: 2839 --WDPARG------AVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKPRLKVETKVSV 2890
              WD   G       +HSTPK D       A WP      +     +G P          
Sbjct: 2759 QGWDSLLGPGAERLPLHSTPK-DGGPGPGKAPWPGDFGTTAKESSGNGAP---------- 2807

Query: 2891 ELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLTLTEQTLKGRL 2950
                EE+    G+    + S G    +S+QP    KGILK K       T++E++    L
Sbjct: 2808 ----EERLRENGDALSREGSLGPLPGSSAQP---HKGILKKKCL----PTISEKS--SLL 2854

Query: 2951 REKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGV---AMNVRTGSAQAD 3007
            R  L  C  S   S  S    GGP      + P R+  ++ LNGV   AM+++ G+   D
Sbjct: 2855 RLPLEQCTGSSRGSSASEGSRGGP----PPRPPPRQSLQEQLNGVMPIAMSIKAGTVDED 2910

Query: 3008 GSDSE 3012
             S SE
Sbjct: 2911 SSGSE 2915


>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
            sapiens]
          Length = 3312

 Score = 2815 bits (7298), Expect = 0.0
 Identities = 1482/2927 (50%), Positives = 1924/2927 (65%), Gaps = 143/2927 (4%)

Query: 80   SGAGRPLPLQVRLVARSAPTALSRRLRARTHLPGCGARARLCGTGARLCGALCFPVPGGC 139
            SG   PLP    L+    P  +S +  A     G G+R R+ GT AR CG L        
Sbjct: 165  SGNSSPLPSDF-LIRHHGPKPVSSQRNA-----GTGSRKRV-GT-ARCCGELW------- 209

Query: 140  AAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVRLRLLCALRRAAGAVRVGLA 199
            A          TT  A R  PR          CLP        L  A R A  A   G A
Sbjct: 210  ATGSKGQGERATTSGAERTAPRRN--------CLPGASGSGPELDSAPRTARTAPASGSA 261

Query: 200  -LEAATAGTPSAS----------------PSPSPPLPPNLPEAR-AGPARRARRGTSGRG 241
              E+ TA  P+                  P P PP  P  PEAR    A RAR   +   
Sbjct: 262  PRESRTAPEPAPKRMRSRGLFRCRFLPQRPGPRPPGLPARPEARKVTSANRARFRRAANR 321

Query: 242  SLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
              +FP  NYQ  + ENE AGT +L++ A     GE  R+ Y +  L + RS   F ID  
Sbjct: 322  HPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQ 381

Query: 302  TGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRER 361
            +G + T + LDRE+ E H LRV A D+ +P  SATT + V V D NDHSPVFEQ++YRE 
Sbjct: 382  SGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRET 441

Query: 362  VRENLEVGYEVLTIRASDRDSPINANLRYRVLG------GAWDVFQLNESSGVVSTRAVL 415
            +REN+E GY +L +RA+D D+P NANLRYR +G       A   F+++  SG++ST   +
Sbjct: 442  LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501

Query: 416  DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLN 475
            DRE    Y+L+VEA+DQG+ PGP SAT  V+I V DENDN PQFSE+ YV QV EDV  +
Sbjct: 502  DREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPH 561

Query: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
            T VLRV ATDRD+  N  +HY+I+SGN  G F + SL+G + V+ PLDFE  ++Y+L I+
Sbjct: 562  TVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIR 621

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
            AQD GRPPL N++G+ S+QV+D+ND+ PIFVS+PFQ +VLEN PLG+ V+HIQAVDAD G
Sbjct: 622  AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681

Query: 596  ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSF 655
            ENARL Y L   A                 PD PF I++++GW++V   LDRE VEHY F
Sbjct: 682  ENARLEYSLTGVA-----------------PDTPFVINSATGWVSVSGPLDRESVEHYFF 724

Query: 656  GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
            GVEA DHGSPP+S+S SV++TVLDVNDN P FT   Y LRLNEDAAVG+SV+++ A DRD
Sbjct: 725  GVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD 784

Query: 716  ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHV 775
            ANS I+YQ+TGGNTRNRFA+S+Q G GL+TLALPLDYKQE+ + L +TASD       +V
Sbjct: 785  ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYV 844

Query: 776  LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQF 835
             IN+TDANTHRPVFQS+HY+VSV+EDRP+G++I  +SA+D+D GENARITY+++D +PQF
Sbjct: 845  HINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQF 904

Query: 836  RIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWD 895
            RID DSG +     LDYE+QV YTL I A+DNGIPQK+DTT +E+++ D NDNAPQF+  
Sbjct: 905  RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVAS 964

Query: 896  FYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRR 955
             Y G + EDAPP TS+LQ+SATDRD+  NGR+ YTFQ G+DGDGDF IEPTSG++RT RR
Sbjct: 965  HYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRR 1024

Query: 956  LDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVG 1015
            LDRE V+VY L A AVDRG P PL   V IQV + D+NDNAP+F  +E E+ V+EN+ VG
Sbjct: 1025 LDREAVSVYELTAYAVDRGVP-PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVG 1083

Query: 1016 SVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQ 1075
            SVVA+I A DPDEGPNA IMYQIVEG++   FQ+D+ +G+L A+++LD+E R+EYV+VVQ
Sbjct: 1084 SVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQ 1143

Query: 1076 ATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVS 1135
            ATSAPLVSRATVH+ LVDQNDN PVL +FQILFNNYV+N+S++FP+G+IG IPA+DPDVS
Sbjct: 1144 ATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVS 1203

Query: 1136 DSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRV 1195
            D L Y+F +GNEL+LL+++  +GEL+LSR LDNNRPL A M V+V+DG+HSVTA C LRV
Sbjct: 1204 DHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRV 1263

Query: 1196 TIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSS 1255
             IIT+++L NS+TVRLENM QE+FLSPLL  F+EGVAAVL+T  +DVF+FN+QNDTDV  
Sbjct: 1264 VIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTDVGG 1323

Query: 1256 NILNVTFSALLP----GGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREP 1311
             +LNV+FSAL P     G  G +F SE+LQEQ+Y+ R  L   S   VLPFDDN+CLREP
Sbjct: 1324 TVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCLREP 1383

Query: 1312 CENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDP 1371
            CENYMKCVSVLRFDSSAPFL+S + LFRPI PI GLRCRCPPGFTGD+CETE+DLCYS+P
Sbjct: 1384 CENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDLCYSNP 1443

Query: 1372 CGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCP 1431
            C   G C  REGGYTC C   FTGE CE+D  +GRC  GVC+NGGTC +   GGF C CP
Sbjct: 1444 CRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFRCQCP 1503

Query: 1432 P-GEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHD 1490
              G +E P CEV  RSFPP SFV FRGLRQRFH T+SL+FAT +++GLL YNGR NEKHD
Sbjct: 1504 AGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHD 1563

Query: 1491 FIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPS 1550
            F+ALE+V  QV+LT+S GE+ T V+P VP G+SDG+WH+V ++YYNKP    LG   GPS
Sbjct: 1564 FLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPS 1623

Query: 1551 GEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDF 1610
             +K+AV++VDDCD  +A++FG +IGNYSCAA G QT SKKSLDLTGPLLLGGVPNLPE+F
Sbjct: 1624 KDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPENF 1683

Query: 1611 PVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNM 1670
            PV ++ F+GCMR+L +DG+ VDMA F+ANNGT  GC A+ +FCD   C+N G C  RW  
Sbjct: 1684 PVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGS 1743

Query: 1671 YLCECPLRFGGKNCEQAMPHPQLFSGESVVSWS-DLNIIISVPWYLGLMFRTRKEDSVLM 1729
            + C+CP+ FGGK+C+  M HP  F G   +SW+   ++ +SVPWYLGL FRTR    VLM
Sbjct: 1744 FSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLM 1803

Query: 1730 EATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSE 1789
            +  +G  ++   Q+    L   V+ G      ++L  + V+DG WH L +EL+       
Sbjct: 1804 QVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRR 1863

Query: 1790 MKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDKV-SVRRGFRGCMQGVRMGG 1848
              H++ ++LD+ + Q+   +G  L GL V+ + VGG          +G  GC+QGV +G 
Sbjct: 1864 GHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLVGCIQGVWLGS 1923

Query: 1849 TPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCV 1908
            TP+    L +  + +V  + GC V + C S PCPP++ C D W+ +SC C  GY G  CV
Sbjct: 1924 TPSGSPAL-LPPSHRVNAEPGCVVTNACASGPCPPHADCRDLWQTFSCTCQPGYYGPGCV 1982

Query: 1909 DACHLNPCENMGACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHC 1968
            DAC LNPC+N G+C   PG+P GY C+C   ++G +CE+++D  CPRGWWG+P CGPC+C
Sbjct: 1983 DACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHRMDQQCPRGWWGSPTCGPCNC 2042

Query: 1969 AVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGV 2028
             V KGFDP+CNKTNGQC CKE +Y+    D+CLPCDC+P GS SR+C   +GQC C+PG 
Sbjct: 2043 DVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQCPCRPGA 2102

Query: 2029 IGRQCNRCDNPFAEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVR 2088
            +GRQCN CD+PFAEVT  GC V+Y+ CPK+  +G+WWPQTKFG  A VPCP+G++G AVR
Sbjct: 2103 LGRQCNSCDSPFAEVTASGCRVLYDACPKSLRSGVWWPQTKFGVLATVPCPRGALGAAVR 2162

Query: 2089 HCSGEKGWLPPELFNCTTISFVDLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTL 2148
             C   +GWL P+LFNCT+ +F +L  + + L  N+T +D   A +L + LR  T HT   
Sbjct: 2163 LCDEAQGWLEPDLFNCTSPAFRELSLLLDGLELNKTALDTMEAKKLAQRLREVTGHTDHY 2222

Query: 2149 FGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIHSGSALLAPATRAAWEQI-Q 2207
            F  DVR   +LL H+L  ES QQGF L ATQDA F+E+++ +GSALLAP T   W  + Q
Sbjct: 2223 FSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLWAGSALLAPETGDLWAALGQ 2282

Query: 2208 RSEG---GTAQLLRRLEGYFSNVARNVRRTYLRPFVIVTANMILAVDIFD-KFNFTGARV 2263
            R+ G   G+A L+R LE Y + +ARN+  TYL P  +VT N++L++D  +   +  GAR 
Sbjct: 2283 RAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPNIMLSIDRMEHPSSPRGAR- 2341

Query: 2264 PRFDTIHEEFPR-----ELESSVSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTE 2318
             R+   H    R     +  + V  P+   RP   +  P        TT     P    E
Sbjct: 2342 -RYPRYHSNLFRGQDAWDPHTHVLLPSQSPRPSPSEVLPTSSSIENSTTSSVVPPPAPPE 2400

Query: 2319 REAPISRRRRHPDDAGQFAVALVIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTL 2378
             E  IS             + ++++YRTLG LLP ++  +RR  RLP  P++N+P+VS  
Sbjct: 2401 PEPGIS-------------IIILLVYRTLGGLLPAQFQAERRGARLPQNPVMNSPVVSVA 2447

Query: 2379 VYSEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNR 2438
            V+     L   LE P+ +EF LL+   R+K +CV W+        G W+AR CEL+ RN 
Sbjct: 2448 VFHGRNFLRGILESPISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNG 2507

Query: 2439 THVACQCSHTASFAVLMDISRRE--NGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRML 2496
            +H  C+CS T +F VLMD S RE   G++  L + T+  V++S+AAL++   +L  +R L
Sbjct: 2508 SHARCRCSRTGTFGVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSL 2567

Query: 2497 RSNLHSIHKHLAVALFLSQLVFVIGINQTENPFLCTVVAILLHYIYMSTFAWTLVESLHV 2556
            +SN+  IH ++A AL +++L+F++GI++T N  +CT VAILLHY ++STFAW  V+ LH+
Sbjct: 2568 KSNVRGIHANVAAALGVAELLFLLGIHRTHNQLVCTAVAILLHYFFLSTFAWLFVQGLHL 2627

Query: 2557 YRMLTEVRNIDTGPMRFYYVVGWGIPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFA 2616
            YRM  E RN+D G MRFY+ +GWG+PA++ GLAVGLDP+GYGNPDFCW+S+ + LIWSFA
Sbjct: 2628 YRMQVEPRNVDRGAMRFYHALGWGVPAVLLGLAVGLDPEGYGNPDFCWISVHEPLIWSFA 2687

Query: 2617 GPIGAVIIINTVTSVLSAKVSCQRKHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVN 2676
            GP+  VI++N    +L+A+ SC        KK     LR++FLLLLL+SA+WL GLLAVN
Sbjct: 2688 GPVVLVIVMNGTMFLLAARTSCSTGQR-EAKKTSALTLRSSFLLLLLVSASWLFGLLAVN 2746

Query: 2677 RDALSFHYLFAIFSGLQGPFVLLFHCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLTR 2736
               L+FHYL A   GLQG  VLL  CVLN + R        GRK   E++    A  L  
Sbjct: 2747 HSILAFHYLHAGLCGLQGLAVLLLFCVLNADARAAWMPACLGRKAAPEEARP--APGLGP 2804

Query: 2737 SLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEGIQKLGVSSG--------LVR------ 2782
                NT   +   ++R  LG ST S  S  R    Q      G        LVR      
Sbjct: 2805 GAYNNTALFEESGLIRITLGASTVSSVSSARSGRTQDQDSQRGRSYLRDNVLVRHGSAAD 2864

Query: 2783 ------GSHGEP---DASLMPRSCKDPPGHDSDSDSELSLDEQSSSYASSHSSDSEDDGV 2833
                   +H  P   D ++  R      G DSDSDS+LSL+E+ S   S  SS+SED+G 
Sbjct: 2865 HTDHSLQAHAGPTDLDVAMFHRDA----GADSDSDSDLSLEEERS--LSIPSSESEDNGR 2918

Query: 2834 GAEEKWDPARGAVHS----TPKGDAVANHVPAGWPDQSLAESDSEDPSGKPRLKVETKVS 2889
                   P   A  S    T   D   N + + WP  +L E ++  P        E ++ 
Sbjct: 2919 TRGRFQRPLCRAAQSERLLTHPKDVDGNDLLSYWP--ALGECEAA-PCALQTWGSERRLG 2975

Query: 2890 VELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYP 2936
            ++  ++   +++ +  P   SG    L  +Q   QRKGILKN++ YP
Sbjct: 2976 LDTSKDAANNNQPD--PALTSGDETSLGRAQ--RQRKGILKNRLQYP 3018


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score =  574 bits (1479), Expect = e-163
 Identities = 493/1766 (27%), Positives = 786/1766 (44%), Gaps = 212/1766 (12%)

Query: 296  FRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQ 355
            F I+ +TG +     L+RE  + + +RV A D      + +T +T+ V D ND++P F +
Sbjct: 2818 FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGW---TVSTDVTIFVTDINDNAPRFSR 2874

Query: 356  SEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVL 415
            + Y     E  E+G +V  + A+D D   N  + Y +   + + F++N ++G +  + +L
Sbjct: 2875 TSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQS-EYFRINATTGEIFNKQIL 2933

Query: 416  DREEAA--------EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQ 467
              +            +  +V ++D+G+ P  +S T TV I + D NDN PQF +  Y   
Sbjct: 2934 KYQNVTGFSNVNINRHSFIVTSSDRGK-PSLISET-TVTINIVDSNDNAPQFLKSKYFTP 2991

Query: 468  VPEDVGLNTAVLRVQATD-RDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFED 526
            V ++V + T ++RV A D +D G N+ + Y I + N  G+F L + +G + V + L  + 
Sbjct: 2992 VTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDL 3051

Query: 527  VQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVH 586
             Q + +++ A+D G PPL +S   V + V + N + P F  S   AT+ E+  +G  V  
Sbjct: 3052 NQNFFITVTAKDKGNPPL-SSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRT 3110

Query: 587  IQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELD 646
            + A D D+  N  + Y +           S+G +         F I++S+G +T+   LD
Sbjct: 3111 VSARDRDAAMNGLIKYSI-----------SSGNEEGI------FAINSSTGILTLAKALD 3153

Query: 647  REEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV 706
             E  + +   + A+D G    +   SV++ V+DVNDN PVF    Y   + E+A  G++V
Sbjct: 3154 YELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTV 3213

Query: 707  LTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTA 764
            + L A D D+  N+VI Y +   ++ + F +    G  +IT    LD++ +Q Y L V A
Sbjct: 3214 IHLNATDADSGTNAVIAYTVQSSDS-DLFVIDPNTG--VITTQGFLDFETKQSYHLTVKA 3270

Query: 765  ---SDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGEN 821
                D  R   A V I +   N + P F S  Y   +SE  P GT +  + A+D D G +
Sbjct: 3271 FNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTD 3330

Query: 822  ARITYVI--QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDT--TT 877
              + Y+I        F+I+  +G +Y    LD E +   +L ++A++ G  + +D    T
Sbjct: 3331 GEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVT 3390

Query: 878  LEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDG 937
            + + +LDAND  P F  + Y   I E  P  T +  VSA D DS P+      F G  + 
Sbjct: 3391 VNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNE 3449

Query: 938  DGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAP 997
            +G F I P +G I     LDRE + +YNL  LAVD G+P+  + S  + VT+ DINDN P
Sbjct: 3450 NGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSA-TGSASLLVTLEDINDNGP 3508

Query: 998  MFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQ--IMYQIVEGDMRHFFQLDLLNGD 1055
            M    E E  V EN   G++V  +++ DPD  PN      Y +  G    +F L    G 
Sbjct: 3509 MLTVSEGE--VMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTA-GV 3565

Query: 1056 LRAMVELDFEVRREYVL--VVQATSAP-LVSRATVHILLVDQNDNPPVLPDFQILFNNYV 1112
            L    E+D E   ++ L  V + +  P + S  TVHI ++DQNDNP      +I  N Y 
Sbjct: 3566 LSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYY- 3624

Query: 1113 TNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLS-RDLDNNRP 1171
                N FP G++G +   DPDV DS + +   G    L  +   T +L    R  D    
Sbjct: 3625 ---GNLFPGGILGSVKPQDPDVLDSFHCSLTSG-VTSLFSIPGGTCDLNSQPRSTDGTFD 3680

Query: 1172 LEALMEVSVSDGIHSVTAFCTLRVTI--ITDDMLTNSITVRLENMSQEKFLSPLLALFVE 1229
            L  L     +DG+HS T    +RV     ++  + NSI +RL   + + FL+     F+ 
Sbjct: 3681 LTVLS----NDGVHS-TVTSNIRVFFAGFSNATVDNSILLRLGVPTVKDFLTNHYLHFLR 3735

Query: 1230 GVAAVLSTTKDDVFVFNV---QNDTDVSSNILNVTFSALLPGGVRGQFFPSEDLQEQIYL 1286
              ++ L+     V +++     N T + + +       + P GV   F   E ++E    
Sbjct: 3736 IASSQLTGLGTAVQLYSAYEENNRTFLLAAVKRNHNQYVNPSGVATFF---ESIKE---- 3788

Query: 1287 NRTLLTTISTQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPING 1346
               +L   S  +V   D + C+  PC+N   C+  L   S      S  V+     P+  
Sbjct: 3789 ---ILLRQSGVKVESVDHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQP 3845

Query: 1347 LRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGR 1406
              C+C PG+ G +CE +ID C   PC + G C +  GG++C C + FTG  CE D     
Sbjct: 3846 FLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDI--NE 3903

Query: 1407 CANGVCKNGGTCVNLLIGGFHCVCPPGEYER----------------------------- 1437
            C    CKNG  C N   G F+CVC  G   +                             
Sbjct: 3904 CLQSPCKNGAICQN-FPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYC 3962

Query: 1438 --------PYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYN--GRFNE 1487
                     +CE+ +  F   S++ F  L    ++ I + FAT + + LLLYN   +  +
Sbjct: 3963 HCPFGVFGKHCELNSYGFEELSYMEFPSLDPNNNY-IYVKFATIKSHALLLYNYDNQTGD 4021

Query: 1488 KHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPH 1547
            + +F+ALEI +E+++ +++ G  T  +       VSDG +H+V  +              
Sbjct: 4022 RAEFLALEIAEERLRFSYNLGSGTYKLT--TMKKVSDGHFHTVIAR-------------- 4065

Query: 1548 GPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDL-TGPLLLGGV--- 1603
                   A +TVD C       +        C           +LD+    + +GG+   
Sbjct: 4066 --RAGMAASLTVDSCSENQEPGY--------CTVSNVAVSDDWTLDVQPNRVTVGGIRSL 4115

Query: 1604 -PNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGG 1662
             P L     V +  FVGC+   +V+G+ ++ +  +A  G  + C      C    CQ+GG
Sbjct: 4116 EPILQRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSPCQHGG 4175

Query: 1663 TCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGE---------------SVVSWSDLNI 1707
            TC++ W+   C C     GK CE+++      S E                 +    L  
Sbjct: 4176 TCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKREYLLRQSLRG 4235

Query: 1708 IISVPW---YLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVML 1764
             +  P+    L + FRTR E+ VL+        +  ++I N  + F    G +      +
Sbjct: 4236 AMLEPFGVNSLEVKFRTRSENGVLIHIQESSNYT-TVKIKNGKVYFTSDAGIAGKVERNI 4294

Query: 1765 SGLRVTDGEWHHLLIELKNVKEDSEM-----KHLVTMTLDYGMDQNKADIGGMLPGLTVR 1819
              + V DG WH  LI          +     + ++  T D+G             GL V 
Sbjct: 4295 PEVYVADGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFG-------------GLDVL 4341

Query: 1820 SVVVGGASEDKV---SVRRGFRGCMQGVRMGGTP---TNVATLNMNNALKVRVKDGCDVD 1873
            ++ +GG   ++    +   GF GC+  +  GG     +   +L   +     VK GC   
Sbjct: 4342 TISLGGIPPNQAHRDAQTAGFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIGCRGP 4401

Query: 1874 DPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYV 1933
            + C S+PC  +  C + W  Y CV             C  +PC+N G+C   PG   G+ 
Sbjct: 4402 NICASNPCWGDLLCINQWYAYRCVPP---------GDCASHPCQNGGSC--EPGLHSGFT 4450

Query: 1934 CECGPSHYGPYCENK---LDLPCPRG 1956
            C C  SH G  CE     L + CP+G
Sbjct: 4451 CSCPDSHTGRTCEMVVACLGVLCPQG 4476



 Score =  465 bits (1197), Expect = e-130
 Identities = 334/982 (34%), Positives = 487/982 (49%), Gaps = 70/982 (7%)

Query: 250  YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDS 309
            Y V++ EN P GT +L L A     G+   V + ++    E  R  FR+D  +G +ST S
Sbjct: 588  YDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEA--ETDRRSFRLDPVSGRLSTIS 645

Query: 310  VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVG 369
             LDRE +  + L V A D  +PP+S+   I V + D ND+SPVF   +Y   ++EN   G
Sbjct: 646  SLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGG 705

Query: 370  YEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEA 429
              + T+ A+D D   N  ++Y +  G    FQ+N  SGV+STR  LDREE   YQL + A
Sbjct: 706  SYITTVSATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVA 765

Query: 430  NDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQG 489
             D G    P  A  T  I V D  DN P FS+  Y   V E+V L   V  V A+  D  
Sbjct: 766  TDGGNLQSPNQAIVT--ITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLN 823

Query: 490  QNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSG 549
             N  I Y I +G+  G F ++ ++G L   N +D E+   Y L + A  G     +    
Sbjct: 824  SN--ISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGG----TVTGDT 877

Query: 550  VVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
            +V++ V D+NDN P F+ +     V+EN   G+ +   +AVD D G N  + Y L     
Sbjct: 878  MVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSL----- 932

Query: 610  TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
                     PKN        F I+  +G I++   LD      Y   + A D G P +SS
Sbjct: 933  ------KQNPKN-------LFAINEKNGTISLLGPLD-VHAGSYQIEILASDMGVPQLSS 978

Query: 670  STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGG 727
            S  +++ V DVNDN PVF Q +YE+ L+E   V S    +QA D+D  AN  I Y +  G
Sbjct: 979  SVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEG 1038

Query: 728  NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT---RSHTAHVLINVTDANT 784
            NT + F +      G + +   LD + + +YVL V ASD      S T +V + + D N 
Sbjct: 1039 NTGDAFGIFPD---GQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVND 1095

Query: 785  HRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTM 844
            +RP+F S++YT    E++  G+ +  +SA D+D G N  + Y  +   P F +   SG +
Sbjct: 1096 NRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEI 1155

Query: 845  YTMMELDYEN------QVAYTLTIMAQDNGIPQK-SDTTTLEILILDANDNAPQFLWDFY 897
                + D E+         ++ T++A D GIPQ   D  T+ + + D NDNAP+FL DFY
Sbjct: 1156 TNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFY 1215

Query: 898  QGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD 957
            Q +I E A   T +L+VSA+D D G NG + Y+   G++ +  F I+ TSG +    +LD
Sbjct: 1216 QATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNE-ERQFAIDSTSGQVTLIGKLD 1274

Query: 958  RENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSV 1017
             E    Y+L   AVD G+  PL+++  + + ILD NDN P F K  L + V EN  +G +
Sbjct: 1275 YEATPAYSLVIQAVDSGT-IPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGEL 1333

Query: 1018 VAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQAT 1077
            V+ + A D D G NA + Y I   +    F +    G +    +LDFE +  Y L + A 
Sbjct: 1334 VSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAK 1393

Query: 1078 S---APLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGV-IGCIPAHDP- 1132
                 P  S  +V I + D NDNPP  P   I F + V N     P G  +  + AHDP 
Sbjct: 1394 DQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDI-FKSIVEN----IPIGTSVISVTAHDPD 1448

Query: 1133 -DVSDSLNYTFVQ----GNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSV 1187
             D++  L+YT +Q    GN      +D   G +  + ++D  R    L E++V     +V
Sbjct: 1449 ADINGQLSYTIIQQMPRGNH---FTIDEVKGTIYTNAEID--REFANLFELTVKANDQAV 1503

Query: 1188 ----TAFCTLRVTIITDDMLTN 1205
                  +    VTI+  D+  N
Sbjct: 1504 PIETRRYALKNVTILVTDLNDN 1525



 Score =  416 bits (1069), Expect = e-115
 Identities = 322/1000 (32%), Positives = 481/1000 (48%), Gaps = 73/1000 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            FP     + + EN   G+ I+QL A    EG    V+Y +    D+     FRID  +G 
Sbjct: 1740 FPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDS----FRIDPESGD 1795

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
            +     LDRE +  + L V+A D     +S+   I + V D NDH+P F +  Y   + E
Sbjct: 1796 LIATRRLDRERRSKYSLLVRADDGL---QSSDMRINITVSDVNDHTPKFSRPVYSFDIPE 1852

Query: 365  NLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEY 423
            +   G  V  I A+D DS +N  + Y V     D +F LN  +GV +   +LD E    Y
Sbjct: 1853 DTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYY 1912

Query: 424  QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQA 483
             L V A D G        T  VY  + D NDN P FS  +Y   + E++ + + VL    
Sbjct: 1913 ILTVRAEDGGGQ----FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNV 1968

Query: 484  TDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPP 543
            TD D G N+ + YSI SG+  GQF +   +G+L V+  LD E    Y+L ++  D  + P
Sbjct: 1969 TDADDGINSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQIP 2027

Query: 544  L--INSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLH 601
                 S+  VS+ +LDVNDN P F+S P    + EN P+   V   QA D DSG N+ + 
Sbjct: 2028 ASRFTSTAQVSIILLDVNDNPPTFLS-PKLTYIPENTPIDTVVFKAQATDPDSGPNSYIE 2086

Query: 602  YRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVD 661
            Y L++                       F I    G + +  ELDREEV +Y+  V A D
Sbjct: 2087 YTLLNPLGN------------------KFSIGTIDGEVRLTGELDREEVSNYTLTVVATD 2128

Query: 662  HGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSV 719
             G P +SSST V + VLD+NDN+P+F Q  Y++ +NE+   G+ ++ + A D D   N  
Sbjct: 2129 KGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQ 2188

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD---GTRSHTAHVL 776
            + Y +  GNT   F + S  G   IT+A PLD ++   Y L V A+D     R+ T+ V 
Sbjct: 2189 VRYGIVNGNTNQEFRIDSVTGA--ITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVS 2246

Query: 777  INVTDANTHRPVFQSSHYTVSVSEDRPVGT---SIATLSANDEDTGENARITYVI--QDP 831
            I + D N   PVF+ S Y+V+V E+  +GT   +I  + A D+D G N++++YV+   + 
Sbjct: 2247 IVLLDINDFVPVFELSPYSVNVPEN--LGTLPRTILQVVARDDDRGSNSKLSYVLFGGNE 2304

Query: 832  VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891
               F +   SG +     LD E +  + L I A D+G P  + T T+ +++ D NDN P 
Sbjct: 2305 DNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPT 2363

Query: 892  FLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIR 951
            F    Y  +I EDAP  T +L V+A+D D+  N  +         G+  F I P++G I 
Sbjct: 2364 FASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRII-----GGNSQFTINPSTGQII 2418

Query: 952  TQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEEN 1011
            T   LDRE    Y L  +  D GSP PLS+S  + VT+ D+NDN P F+       +   
Sbjct: 2419 TSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSP 2478

Query: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREY- 1070
               GS V  +   D D GPN+++ Y +  G     F +D L G + A   L+      + 
Sbjct: 2479 TLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEKFHIDPLRGAIMAAGPLNGASEVTFS 2537

Query: 1071 VLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAH 1130
            V V    S P     TV +  V++ D P V    Q  F        +S  T + G     
Sbjct: 2538 VHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQ-TFMFPENQPVSSLVTTITGSSLRG 2596

Query: 1131 DPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTA 1189
            +P     ++Y    GN      +D  TG++ +S+ LD  +  + ++ +   D G    ++
Sbjct: 2597 EP-----MSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSS 2651

Query: 1190 FCTLRVTIITDDMLTNS--------ITVRLENMSQEKFLS 1221
            +  L +T++  D+  N+        I+  LEN+S  K L+
Sbjct: 2652 YEKLDITVL--DVNDNAPIFKEDPFISEILENLSPRKILT 2689



 Score =  402 bits (1034), Expect = e-111
 Identities = 290/952 (30%), Positives = 475/952 (49%), Gaps = 57/952 (5%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            KF  P Y   + E+   G+L+  + A     G    ++Y +    ++   G F ++  TG
Sbjct: 1840 KFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVN---EDDEDGIFFLNPITG 1896

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
              +   +LD E ++ ++L V+A D      +   Y  +L  D ND+ P+F  + Y   + 
Sbjct: 1897 VFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNIL--DVNDNPPIFSLNSYSTSLM 1954

Query: 364  ENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
            ENL VG  VL    +D D  IN+ L Y +  G        + +GV+     LDRE  + Y
Sbjct: 1955 ENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLKALDRESQSFY 2014

Query: 424  QLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ 482
             L+V+ +D  + P    ++TA V I + D NDN P F     +  +PE+  ++T V + Q
Sbjct: 2015 NLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPK-LTYIPENTPIDTVVFKAQ 2073

Query: 483  ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP 542
            ATD D G N+ I Y++L+  +  +F + ++ G + +   LD E+V  Y+L++ A D G+P
Sbjct: 2074 ATDPDSGPNSYIEYTLLNP-LGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQP 2132

Query: 543  PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHY 602
             L +S+ VV V VLD+NDN PIF  + ++  + EN   G  ++ + A D D G N ++ Y
Sbjct: 2133 SLSSSTEVV-VMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRY 2191

Query: 603  RLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDH 662
             +V+           G  N        F+I + +G ITV   LDRE+   Y   V+A D 
Sbjct: 2192 GIVN-----------GNTNQE------FRIDSVTGAITVAKPLDREKTPTYHLTVQATDR 2234

Query: 663  GSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNED-AAVGSSVLTLQARDRD--ANSV 719
            GS P + +++VSI +LD+ND  PVF    Y + + E+   +  ++L + ARD D  +NS 
Sbjct: 2235 GSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSK 2294

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLIN 778
            ++Y L GGN  N F LS+    G + +   LD + ++++VL +TA+D G+ + T    IN
Sbjct: 2295 LSYVLFGGNEDNAFTLSAS---GELGVTQSLDRETKERFVLMITATDSGSPALTGTGTIN 2351

Query: 779  VT--DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFR 836
            V   D N + P F S  Y  ++ ED P GT +  ++A+D D  +NA I  +  +   QF 
Sbjct: 2352 VIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGNS--QFT 2409

Query: 837  IDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK-SDTTTLEILILDANDNAPQFLWD 895
            I+P +G + T   LD E +  YTL ++  D G P+  S +T++ + + D NDN P+F   
Sbjct: 2410 INPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHH 2469

Query: 896  FYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRR 955
             Y   I     P + +  V+ TD D GPN  L Y+  G +     F+I+P  G I     
Sbjct: 2470 PYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEK--FHIDPLRGAIMAAGP 2527

Query: 956  LDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVG 1015
            L+  +   +++    V  G   P + S  + V  ++  D   +  K++  +F  EN PV 
Sbjct: 2528 LNGASEVTFSVH---VKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMF-PENQPVS 2583

Query: 1016 SVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQ 1075
            S+V  I  +     P   + Y I  G++ + FQ+D L G +     LDFE  ++YV+ ++
Sbjct: 2584 SLVTTITGSSLRGEP---MSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIE 2640

Query: 1076 ATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDP 1132
            A      P  S   + I ++D NDN P+  +     + +++    +     I  + A D 
Sbjct: 2641 ARDGGFPPFSSYEKLDITVLDVNDNAPIFKE-----DPFISEILENLSPRKILTVSAMDK 2695

Query: 1133 DVSDS--LNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
            D   +  L+Y  V GN      ++ ATGE++  R LD  +    ++ +  SD
Sbjct: 2696 DSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSD 2747



 Score =  384 bits (986), Expect = e-106
 Identities = 325/1052 (30%), Positives = 488/1052 (46%), Gaps = 77/1052 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F   +Y+V L E+EP  +   ++ A     G    ++Y +       + G F      G 
Sbjct: 996  FDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIF----PDGQ 1051

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
            +   S LDRE ++ +VL V A D +  P SAT  +TV+++D ND+ P+F  + Y     E
Sbjct: 1052 LYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEE 1111

Query: 365  NLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREE----- 419
                G  V  + A D+D   N  +RY       D F+L+  SG ++     DRE      
Sbjct: 1112 EQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPD-FELHAISGEITNTHQFDRESLMRRR 1170

Query: 420  -AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
              A +   V A DQG  P PL   ATV++ ++D NDN P+F +  Y   + E     T V
Sbjct: 1171 GTAVFSFTVIATDQGI-PQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQV 1229

Query: 479  LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD 538
            LRV A+D D+G N  IHYSI+ GN   QF + S SG + +I  LD+E    YSL I+A D
Sbjct: 1230 LRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVD 1289

Query: 539  GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
             G  PL NS+  +++ +LD NDN P F  S     VLEN+ +G  V  + A D+DSG+NA
Sbjct: 1290 SGTIPL-NSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNA 1348

Query: 599  RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658
             L+Y +  T +                    F I  ++G I +  +LD E    Y   + 
Sbjct: 1349 DLYYSITGTNN-----------------HGTFSISPNTGSIFLAKKLDFETQSLYKLNIT 1391

Query: 659  AVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA-- 716
            A D G PP SS+ SV I V D NDN P F        + E+  +G+SV+++ A D DA  
Sbjct: 1392 AKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADI 1451

Query: 717  NSVITYQLTGGNTR-NRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT------R 769
            N  ++Y +     R N F +   +G   I     +D +    + L V A+D        R
Sbjct: 1452 NGQLSYTIIQQMPRGNHFTIDEVKG--TIYTNAEIDREFANLFELTVKANDQAVPIETRR 1509

Query: 770  SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VI 828
                +V I VTD N + P+F S +  ++      +G+ + T+ A D D G N  I Y +I
Sbjct: 1510 YALKNVTILVTDLNDNVPMFISQN-ALAADPSAVIGSVLTTIMAADPDEGANGEIEYEII 1568

Query: 829  QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDN 888
                  F +D  SG +     L   +Q+ Y L + A D G  ++  TT L I++   +  
Sbjct: 1569 NGDTDTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTIILQGLD-- 1625

Query: 889  APQFLWDFYQGSIFEDAPPSTSILQVSATDR--DSGPNGRLLYTFQGGDDGDGD-FYIEP 945
             P F    Y   + E  P  T+++ + A        P    + + +  +   G  F I  
Sbjct: 1626 GPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGR 1685

Query: 946  TSGVIRTQRRLDRENVA-VYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDEL 1004
             +G+I+T   LDRE  A +Y +   A+++ +  P +   E+++T+ DINDN P+F  D L
Sbjct: 1686 HTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDML 1745

Query: 1005 ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDF 1064
            +L VEEN   GS + ++ A D DEG NA + Y I+ G     F++D  +GDL A   LD 
Sbjct: 1746 DLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDLIATRRLDR 1804

Query: 1065 EVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVI 1124
            E R +Y L+V+A      S   ++I + D ND+ P        F+       ++ P  ++
Sbjct: 1805 ERRSKYSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFD----IPEDTIPGSLV 1860

Query: 1125 GCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
              I A D D  V+  + Y   + +E  +  L+P TG   L+R LD       ++ V   D
Sbjct: 1861 AAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAED 1920

Query: 1183 GIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDV 1242
            G      F T+RV     D+  N     L + S     + L+     G           V
Sbjct: 1921 G---GGQFTTIRVYFNILDVNDNPPIFSLNSYS-----TSLMENLPVG---------STV 1963

Query: 1243 FVFNVQNDTDVSSNILNVTFSALLPGGVRGQF 1274
             VFNV   TD    I +    ++  G   GQF
Sbjct: 1964 LVFNV---TDADDGINSQLTYSIASGDSLGQF 1992



 Score =  377 bits (968), Expect = e-104
 Identities = 293/896 (32%), Positives = 435/896 (48%), Gaps = 93/896 (10%)

Query: 248  PNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVST 307
            P     + E +P GTL+  +    T  G   R+S          S   F I+S+TGA+ T
Sbjct: 45   PRQVFQVLEEQPPGTLVGTIQ---TRPGFTYRLS---------ESHALFAINSSTGALYT 92

Query: 308  DSVLDRETKETHVLRVKAVDYSTPPRSATTYIT---VLVKDTNDHSPVFEQSEYRERVRE 364
             S +DRE+  + V+ +  +       SA TY T   VLV+D ND++PVF         +E
Sbjct: 93   TSTIDRESLPSDVINLVVLS------SAPTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKE 146

Query: 365  NLEVGYEVLTIRASDRDSPINA--NLRYRVLGG------AWDVFQLNESSGV---VSTRA 413
            +   G +V+   A+D D   N   +  YR++ G        D+       G    + ++ 
Sbjct: 147  DSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKG 206

Query: 414  VLDREEAAEYQLLVEANDQG--RNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPED 471
             LDRE   +YQLLVE  D+G  +  G L    T    V+D NDN P F   +Y   VPED
Sbjct: 207  GLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVT----VQDINDNPPVFGSSHYQAGVPED 262

Query: 472  VGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYS 531
              + ++VL+V A D D+G NA I Y +        F +   +G++ V  PLDFE  ++YS
Sbjct: 263  AVVGSSVLQVAAADADEGTNADIRYRLQDEGT--PFQMDPETGLITVREPLDFEARRQYS 320

Query: 532  LSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI-----FVSSPFQATVLENVPLGYPVVH 586
            L+++A D G P L   +  + +Q+LDVNDN+P+     F ++   A+V EN  +G  V  
Sbjct: 321  LTVQAMDRGVPSLTGRAEAL-IQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVAL 379

Query: 587  IQAVDADS-GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSS----GWITV 641
            +   DADS   N  +  ++       LGG               F++ +S       I V
Sbjct: 380  LTVTDADSPAANGNISVQI-------LGGNE----------QRHFEVQSSKVPNLSLIKV 422

Query: 642  CAELDREEVEHYSFGVEAVD-HGSPP------MSSSTSVSITVLDVNDNDPVFTQPTYEL 694
             + LDRE +  Y+  V   D +G+PP       SS  S+ I V D+ND+ PVF+Q  Y +
Sbjct: 423  ASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRV 482

Query: 695  RLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALP--L 750
             L+E+A  GS V  + A D D+  N+ + Y +  GN    F +S     GL+T      L
Sbjct: 483  NLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEH--SGLVTTGSSGGL 540

Query: 751  DYKQEQQYVLAVTASD---GTRSHTAHVLINVTDANTHRPVF-QSSHYTVSVSEDRPVGT 806
            D +   Q VL ++A D     +   A +++ + D N  +PVF Q   Y VSV E+ P GT
Sbjct: 541  DRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGT 600

Query: 807  SIATLSANDEDTGENARITYVIQDPVP---QFRIDPDSGTMYTMMELDYENQVAYTLTIM 863
             +  L A D D G+N  + + +Q+       FR+DP SG + T+  LD E Q  Y+L ++
Sbjct: 601  ELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVL 660

Query: 864  AQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGP 923
            A D G P +S    + + +LD NDN+P F    Y   I E+ P  + I  VSATD D G 
Sbjct: 661  ATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGT 720

Query: 924  NGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASV 983
            NG + Y+   GD     F +   SGVI T+  LDRE    Y L  +A D G+    + ++
Sbjct: 721  NGTVKYSISAGD--RSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAI 778

Query: 984  EIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDM 1043
             + +T+LD  DN P+F +      V EN  +G  V  + A+  D   N+ I Y I  GD 
Sbjct: 779  -VTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMD--LNSNISYLITTGDQ 835

Query: 1044 RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPP 1099
            +  F ++ + G L     +D E +  Y L V A+   +     V+I + D NDN P
Sbjct: 836  KGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGDTMVNITVKDLNDNSP 891



 Score =  367 bits (943), Expect = e-101
 Identities = 275/841 (32%), Positives = 404/841 (48%), Gaps = 79/841 (9%)

Query: 399  VFQLNESSGVVSTRAVLDREEAAEYQL-LVEANDQGRNPGPLSATATVYIEVEDENDNYP 457
            +F +N S+G + T + +DRE      + LV  +     P        V + V D NDN P
Sbjct: 80   LFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYP------TEVRVLVRDLNDNAP 133

Query: 458  QFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIH--YSILSGNVAGQFYL------ 509
             F + + VV   ED      V+   ATD D G N   H  Y I+ GN AG+F L      
Sbjct: 134  VFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNP 193

Query: 510  HSLSGILDVINP--LDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVS 567
                  L +++   LD E   +Y L ++ +D G P        V+V V D+NDN P+F S
Sbjct: 194  SGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKR-RGYLQVNVTVQDINDNPPVFGS 252

Query: 568  SPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPD 627
            S +QA V E+  +G  V+ + A DAD G NA + YRL D  +                  
Sbjct: 253  SHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGT------------------ 294

Query: 628  FPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPV- 686
             PFQ+   +G ITV   LD E    YS  V+A+D G P ++      I +LDVNDNDPV 
Sbjct: 295  -PFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVV 353

Query: 687  ----FTQPTYELRLNEDAAVGSSVLTLQARDRD---ANSVITYQLTGGNTRNRFALSSQR 739
                F   +    ++E+A VG+ V  L   D D   AN  I+ Q+ GGN +  F + S +
Sbjct: 354  KFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSK 413

Query: 740  --GGGLITLALPLDYKQEQQYVLAVTASDG----------TRSHTAHVLINVTDANTHRP 787
                 LI +A  LD ++   Y L V+ SD            RS  A ++I V D N H P
Sbjct: 414  VPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPP 473

Query: 788  VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY--VIQDPVPQFRIDPDSGTMY 845
            VF    Y V++SE+ P G+ ++ +SA D D+G NA + Y  V  + +  F I   SG + 
Sbjct: 474  VFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVT 533

Query: 846  TMME--LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLW-DFYQGSIF 902
            T     LD E      L I A+D G+  K     L + +LD ND  P F   + Y  S+ 
Sbjct: 534  TGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVV 593

Query: 903  EDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVA 962
            E+AP  T +L + ATD D G NG + ++ Q  +     F ++P SG + T   LDRE  A
Sbjct: 594  ENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQA 653

Query: 963  VYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIR 1022
             Y+L  LA D GSP P S+   I V++LDINDN+P+F   +    ++EN P GS +  + 
Sbjct: 654  FYSLLVLATDLGSP-PQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVS 712

Query: 1023 ANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV 1082
            A DPD G N  + Y I  GD R  FQ++  +G +   + LD E +  Y L + AT    +
Sbjct: 713  ATDPDLGTNGTVKYSISAGD-RSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNL 771

Query: 1083 ---SRATVHILLVDQNDNPPVLPDFQ---ILFNNYVTNKSNSFPTGVIGCIPAHDPDVSD 1136
               ++A V I ++D  DNPPV        ++F N             +G + A   D++ 
Sbjct: 772  QSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYH-------VGSVSASTMDLNS 824

Query: 1137 SLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVT 1196
            +++Y    G++  +  ++  TG+L  +  +D        ++V  S G  +VT    + +T
Sbjct: 825  NISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGG--TVTGDTMVNIT 882

Query: 1197 I 1197
            +
Sbjct: 883  V 883



 Score =  358 bits (918), Expect = 6e-98
 Identities = 267/942 (28%), Positives = 450/942 (47%), Gaps = 67/942 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F    Y   + E+ P GT +L ++A    +  +  V   + G         F I+ +TG 
Sbjct: 2364 FASKAYFTTIPEDAPTGTDVLLVNAS-DADASKNAVIRIIGG------NSQFTINPSTGQ 2416

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTP-PRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
            + T ++LDRETK+ + L V   D  +P P S++T + V V D ND+ P F+   Y   + 
Sbjct: 2417 IITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIP 2476

Query: 364  ENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
                 G  V  +  +D D   N+ L Y + G   + F ++   G +     L+   A+E 
Sbjct: 2477 SPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNG--ASEV 2534

Query: 424  QLLVEANDQGRNPGPLSATATV-YIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ 482
               V   D G  P   S T TV ++   D    +P+   +      PE+  +++ V  + 
Sbjct: 2535 TFSVHVKDGGSFPKTDSTTVTVRFVNKAD----FPKVRAKEQTFMFPENQPVSSLVTTIT 2590

Query: 483  ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP 542
             +     +   + Y I SGN+   F +  L+G + +  PLDFE +QKY + I+A+DGG P
Sbjct: 2591 GSSL---RGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP 2647

Query: 543  PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHY 602
            P  +S   + + VLDVNDN PIF   PF + +LEN+     ++ + A+D DSG N +L Y
Sbjct: 2648 PF-SSYEKLDITVLDVNDNAPIFKEDPFISEILENLS-PRKILTVSAMDKDSGPNGQLDY 2705

Query: 603  RLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDH 662
             +V+                    +  F I++++G I     LDRE+V HY   +++ D 
Sbjct: 2706 EIVNG-----------------NMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDK 2748

Query: 663  GSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVI 720
            GSP  S+S  V I +LD NDN P F+Q  +   + E++ +G +V  +   D D   N++ 
Sbjct: 2749 GSPSQSTSVKVMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAIS 2807

Query: 721  TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVT 780
             Y +   +    F ++   G   I ++ PL+ +   +Y + V+A D   + +  V I VT
Sbjct: 2808 RYSIMDASL--PFTINPSTGD--IVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVT 2863

Query: 781  DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPD 840
            D N + P F  + Y +   E   +G+ +  + A D D G N ++ Y I+     FRI+  
Sbjct: 2864 DINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINAT 2923

Query: 841  SGTMYTMMELDYENQVAY--------TLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
            +G ++    L Y+N   +        +  + + D G P     TT+ I I+D+NDNAPQF
Sbjct: 2924 TGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQF 2983

Query: 893  LWDFYQGSIFEDAPPSTSILQVSA-TDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIR 951
            L   Y   + ++    T +++V+A  D+D G N  + Y F   D+  G F ++  +G I 
Sbjct: 2984 LKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEY-FISNDNHLGKFKLDNDTGWIS 3042

Query: 952  TQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEEN 1011
                L  +    + +   A D+G+P PLS+   + +T+ + N + P F +  +   + E+
Sbjct: 3043 VASSLISDLNQNFFITVTAKDKGNP-PLSSQATVHITVTEENYHTPEFSQSHMSATIPES 3101

Query: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
            + +GS+V  + A D D   N  I Y I  G+    F ++   G L     LD+E+ +++ 
Sbjct: 3102 HSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHE 3161

Query: 1072 LVVQATSAPLVSR---ATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCI 1127
            + + A     V+R    +V + ++D NDN PV      L ++Y      + P+G  +  +
Sbjct: 3162 MTISAIDGGWVARTGYCSVTVNVIDVNDNSPV-----FLSDDYFPTVLENAPSGTTVIHL 3216

Query: 1128 PAHDPDVSDS--LNYTFVQGNELRLLLLDPATGELQLSRDLD 1167
             A D D   +  + YT VQ ++  L ++DP TG +     LD
Sbjct: 3217 NATDADSGTNAVIAYT-VQSSDSDLFVIDPNTGVITTQGFLD 3257



 Score =  343 bits (879), Expect = 2e-93
 Identities = 296/1000 (29%), Positives = 453/1000 (45%), Gaps = 77/1000 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRID----- 299
            FP P+  V   E+  +G  ++   A  +  G    V +    +      G FR+D     
Sbjct: 135  FPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNG-VDHRSYRIIRGNEAGRFRLDITLNP 193

Query: 300  SATGA---VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
            S  GA   + +   LDRE    + L V+  D   P R     + V V+D ND+ PVF  S
Sbjct: 194  SGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSS 253

Query: 357  EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
             Y+  V E+  VG  VL + A+D D   NA++RYR L      FQ++  +G+++ R  LD
Sbjct: 254  HYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYR-LQDEGTPFQMDPETGLITVREPLD 312

Query: 417  REEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYP-----QFSEQNYVVQVPED 471
             E   +Y L V+A D+G     L+  A   I++ D NDN P      F   +    V E+
Sbjct: 313  FEARRQYSLTVQAMDRG--VPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDEN 370

Query: 472  VGLNTAVLRVQATDRDQ-GQNAAIHYSILSGNVAGQFYLHSLS----GILDVINPLDFED 526
              + T V  +  TD D    N  I   IL GN    F + S       ++ V + LD E 
Sbjct: 371  AQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRER 430

Query: 527  VQKYSLSIKAQDG-GRPP---LINSSGVVSVQVL--DVNDNEPIFVSSPFQATVLENVPL 580
            +  Y+L++   D  G PP   +   S V S+ +   D+ND+ P+F    ++  + E  P 
Sbjct: 431  IPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPP 490

Query: 581  GYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWIT 640
            G  V  I A D DSG NA L Y +V       G G              F I   SG +T
Sbjct: 491  GSYVSGISATDGDSGLNANLRYSIVS------GNGLGW-----------FHISEHSGLVT 533

Query: 641  VCAE--LDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPT-YELRLN 697
              +   LDRE        + A D G  P  S   + +T+LDVND  PVF+QP  Y++ + 
Sbjct: 534  TGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVV 593

Query: 698  EDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQE 755
            E+A  G+ +L L+A D D   N  + + L    T  R        G L T++  LD +++
Sbjct: 594  ENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTIS-SLDREEQ 652

Query: 756  QQYVLAVTASD---GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLS 812
              Y L V A+D     +S  A + +++ D N + PVF    Y   + E+ P G+ I T+S
Sbjct: 653  AFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVS 712

Query: 813  ANDEDTGENARITYVIQ-DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQ 871
            A D D G N  + Y I      +F+++  SG + T M LD E + AY L I+A D G  Q
Sbjct: 713  ATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQ 772

Query: 872  KSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTF 931
              +   + I +LD  DN P F    Y   +FE+      +  VSA+  D   N  + Y  
Sbjct: 773  SPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDL--NSNISYLI 830

Query: 932  QGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILD 991
              GD   G F I   +G + T   +DRE  + Y L  +A    S   ++    + +T+ D
Sbjct: 831  TTGDQ-KGMFAINQVTGQLTTANVIDREEQSFYQLKVVA----SGGTVTGDTMVNITVKD 885

Query: 992  INDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDL 1051
            +NDN+P F +    + V EN   G  + + +A DPDEG N  ++Y + + + ++ F ++ 
Sbjct: 886  LNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINE 944

Query: 1052 LNGDLRAMVELDFEVRREYV-LVVQATSAPLVSRATVHILLV-DQNDNPPVLPDFQILFN 1109
             NG +  +  LD       + ++      P +S + +  + V D NDN PV         
Sbjct: 945  KNGTISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQL----- 999

Query: 1110 NYVTNKSNSFPTGV-IGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDL 1166
            +Y    S S P       + A D D   +  + YT  +GN      + P  G+L +  +L
Sbjct: 1000 SYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFP-DGQLYIKSEL 1058

Query: 1167 DNN-RPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTN 1205
            D   +    LM V+    +  ++A  T+ VT+I +D+  N
Sbjct: 1059 DRELQDRYVLMVVASDRAVEPLSA--TVNVTVILEDVNDN 1096



 Score =  325 bits (832), Expect = 5e-88
 Identities = 242/807 (29%), Positives = 400/807 (49%), Gaps = 58/807 (7%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +F   +Y +   E    G+ + Q+ A    EG   +V Y+++   +     YFRI++ TG
Sbjct: 2871 RFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSE-----YFRINATTG 2925

Query: 304  AVSTDSVLDRETK--------ETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQ 355
             +    +L  +            H   V + D   P   + T +T+ + D+ND++P F +
Sbjct: 2926 EIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLK 2985

Query: 356  SEYRERVRENLEVGYEVLTIRA-SDRDSPINANLRYRVLG-GAWDVFQLNESSGVVSTRA 413
            S+Y   V +N++VG +++ + A  D+D  +N+ + Y +        F+L+  +G +S  +
Sbjct: 2986 SKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVAS 3045

Query: 414  VLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVG 473
             L  +    + + V A D+G NP PLS+ ATV+I V +EN + P+FS+ +    +PE   
Sbjct: 3046 SLISDLNQNFFITVTAKDKG-NP-PLSSQATVHITVTEENYHTPEFSQSHMSATIPESHS 3103

Query: 474  LNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
            + + V  V A DRD   N  I YSI SGN  G F ++S +GIL +   LD+E  QK+ ++
Sbjct: 3104 IGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMT 3163

Query: 534  IKAQDGGRPPLINSSGV--VSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVD 591
            I A DGG    +  +G   V+V V+DVNDN P+F+S  +  TVLEN P G  V+H+ A D
Sbjct: 3164 ISAIDGG---WVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATD 3220

Query: 592  ADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVE 651
            ADSG NA + Y +  + S                    F I  ++G IT    LD E  +
Sbjct: 3221 ADSGTNAVIAYTVQSSDSDL------------------FVIDPNTGVITTQGFLDFETKQ 3262

Query: 652  HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA 711
             Y   V+A +       S  +V+I +   N+  P F    Y   ++E A  G+ V  + A
Sbjct: 3263 SYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFA 3322

Query: 712  RDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD--- 766
             DRD   +  + Y + G + +  F ++ +   G I ++  LD ++E++  L V A +   
Sbjct: 3323 SDRDLGTDGEVHYLIFGNSRKKGFQINKKT--GQIYVSGILDREKEERVSLKVLAKNFGS 3380

Query: 767  --GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGEN-AR 823
              G       V + V DAN   P+F  + Y+V +SE  P+GT +  +SA D D+  + +R
Sbjct: 3381 IRGADIDEVTVNVTVLDAN-DPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSR 3439

Query: 824  ITYVI--QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEIL 881
             +Y I   +    F I+P +G +    ELD E    Y L+++A D+G P  + + +L + 
Sbjct: 3440 FSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVT 3499

Query: 882  ILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN-GRLLYTFQGGDDGDGD 940
            + D NDN P  +    +G + E+  P T ++ + +TD D  PN G   Y           
Sbjct: 3500 LEDINDNGP--MLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSY 3557

Query: 941  FYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE 1000
            F +  T+GV+ T R +DRE +A + L  +  D G P  +S++  + +T++D NDN     
Sbjct: 3558 FSLS-TAGVLSTTREIDREQIADFYLSVVTKDSGVP-QMSSTGTVHITVIDQNDNPSQSR 3615

Query: 1001 KDELELFVEENNPVGSVVAKIRANDPD 1027
              E+ +    N   G ++  ++  DPD
Sbjct: 3616 TVEIFVNYYGNLFPGGILGSVKPQDPD 3642



 Score = 62.4 bits (150), Expect = 7e-09
 Identities = 41/129 (31%), Positives = 56/129 (43%), Gaps = 29/129 (22%)

Query: 1870 CDVD-DPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINC---VDACHLNPCENMGACVRS 1925
            C++D D C  SPC     CH+    +SC C  G+ G  C   ++ C  +PC+N   C   
Sbjct: 3859 CEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNF 3918

Query: 1926 PGS-----PQGYV----------CECGPSHYGPYCENKLD---LPCPRGWWGNPVCGPCH 1967
            PGS       GY           CEC P   G  C++ +D     CP G +G       H
Sbjct: 3919 PGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGK------H 3972

Query: 1968 CAV-SKGFD 1975
            C + S GF+
Sbjct: 3973 CELNSYGFE 3981



 Score = 49.7 bits (117), Expect = 4e-05
 Identities = 44/181 (24%), Positives = 68/181 (37%), Gaps = 45/181 (24%)

Query: 1909 DACHLNPCENMGACVRS------------------PGSP-QGYVCECGPSHYGPYCENKL 1949
            D+C   PC+N G+C+R                      P Q ++C+C P + G +CE  +
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDI 3863

Query: 1950 D----LPCPRGWWGNPVCGPCHCAVSKGF-----DPDCNK------TNG----------Q 1984
            D     PC  G   + + G   C+   GF     + D N+       NG           
Sbjct: 3864 DECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGSFN 3923

Query: 1985 CQCKENYYKLLAQDTCLPCDCFP-HGSHSRTCDMATGQCACKPGVIGRQCNRCDNPFAEV 2043
            C CK  Y   + + +   C+C P     S    + +  C C  GV G+ C      F E+
Sbjct: 3924 CVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCELNSYGFEEL 3983

Query: 2044 T 2044
            +
Sbjct: 3984 S 3984


>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
          Length = 4557

 Score =  460 bits (1183), Expect = e-128
 Identities = 403/1422 (28%), Positives = 632/1422 (44%), Gaps = 147/1422 (10%)

Query: 294  GYFRIDSATGAVSTDSVLDRETKETHVLRVKA-VDYSTPPRSATTYITVLVKDTNDHSPV 352
            G F I+  TG +  D  LDRET      +V A +         T  + + V D ND+ PV
Sbjct: 2754 GIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPV 2813

Query: 353  FEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGA-----WDVFQLNESSG 407
            FE S Y   + E + VG ++  +RA D D   N  + Y +   +      + F ++ ++G
Sbjct: 2814 FETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTG 2873

Query: 408  VVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQ 467
             +ST   LD E    +   V A+D G     LS+TA V + V D NDN P F+++ Y   
Sbjct: 2874 WISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTALVSVRVTDINDNAPVFAQEVYRGN 2932

Query: 468  VPEDVGLNTAVLRVQATDRDQGQ-NAAIHYSILSGNVAGQFYLHSLSGILDVI--NPLDF 524
            V E       V  +   DRD    N  + Y I  GN  G+F L  +     V    PLD 
Sbjct: 2933 VKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDR 2992

Query: 525  EDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV 584
            E+   Y L+I A DG    L  +  +V V V DVNDN P+     + A + E++P    +
Sbjct: 2993 EEQDIYFLNITATDG----LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKII 3048

Query: 585  VHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE 644
            + + A DAD G N  + Y L        G G++            F +   SG +   A 
Sbjct: 3049 LKVSAKDADIGSNGYIRYSLY-------GSGNS-----------EFFLDPESGELKTLAL 3090

Query: 645  LDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGS 704
            LDRE +  YS   +A D G     S+  + + + DVNDN PVF+   Y   + E+ A  +
Sbjct: 3091 LDRERIPVYSLMAKATDGGGRFCQSN--IHLILEDVNDNPPVFSSDHYNTCVYENTATKA 3148

Query: 705  SVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAV 762
             +  +QA D D   N  + Y L   +    F++ S    G+I L  PLD +Q+  Y ++V
Sbjct: 3149 LLTRVQAVDPDIGINRKVVYSLAD-SAGGVFSIDSS--SGIIILEQPLDREQQSSYNISV 3205

Query: 763  TASDGTR----SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDT 818
             A+D +     S    V I V D N + PVF+   Y V+V ED   GT +  + A  +D 
Sbjct: 3206 RATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDI 3265

Query: 819  GENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTT 876
            G NA ITY+I+    Q  F+I+P +G +     LDYE    + L + A+D G P  S   
Sbjct: 3266 GTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVA 3325

Query: 877  TLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDD 936
            T+ I + D NDN P+F  D Y   I EDA    S++ + A D DS PNG++ ++   GD 
Sbjct: 3326 TVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDR 3385

Query: 937  GDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNA 996
             D +F ++P  G+++ +++LDRE V+ Y+L   AVD G P  +S++  + + I D+NDN+
Sbjct: 3386 -DNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPA-MSSTATVNIDISDVNDNS 3443

Query: 997  PMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQ-IMYQIVEGDMRHFFQLDLLNGD 1055
            P+F        ++EN PVG+ + ++   D D   N     + I+ G+    F LD  +G 
Sbjct: 3444 PVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDP-HGI 3502

Query: 1056 LRAMVELDFEVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYV 1112
            LR+ V        EYVL VQA  +     VS   + + +++++ + P     +I    ++
Sbjct: 3503 LRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEI----FI 3558

Query: 1113 TNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPL 1172
                + FP GVIG I A D D+ D L +  ++  +  L  ++   G++     LD+ +  
Sbjct: 3559 VTMEDDFPGGVIGKIHATDQDMYDVLTFA-LKSEQKSLFKVNSHDGKIIALGGLDSGK-- 3615

Query: 1173 EALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVA 1232
              ++ VSVSDG   V     + V  +  +ML N++T+R EN+S E F+   +  F   + 
Sbjct: 3616 -YVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLR 3674

Query: 1233 -AVLSTTKDDVFVFNVQNDTDVSSNILNVTFSALLPGGVRGQFFPSEDLQEQIYLNRTLL 1291
             AVL+  +D + + ++Q      +N L++ F+  +      +F+    L +++   R  L
Sbjct: 3675 NAVLTQKQDSLRIISIQ--PVAGTNQLDMLFAVEMHS---SEFYKPAYLIQKLSNARRHL 3729

Query: 1292 TTISTQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTT-VLFRPIHPINGLRCR 1350
              I   R+    +  C    C+    C   L  DS A    ST  + F        +RC 
Sbjct: 3730 ENI--MRISAILEKNCSGLDCQE-QHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCT 3786

Query: 1351 CPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANG 1410
            C     G  C    D C   PC  + +C S E                            
Sbjct: 3787 C----NGGLCPGSNDPCVEKPCPGDMQCVSYEASRR------------------------ 3818

Query: 1411 VCKNGGTCVNLLIGGFHCVCPPGEYERPYCE-VTTRSFPPQSFVTFR--GLRQRFHFTIS 1467
                           F C CPPG+     C   T+ SF   S++ +R     +   F ++
Sbjct: 3819 --------------PFLCQCPPGKLGE--CSGHTSLSFAGNSYIKYRLSENSKEEDFKLA 3862

Query: 1468 LTFATQERNGLLLYNGRFNEKHDFIALEIVDEQV--QLTFSAGETTTTVAPKVPSGVSDG 1525
            L   T + NG+++Y       +  I L+IVD ++  QL   +G     ++ +    V+DG
Sbjct: 3863 LRLRTLQSNGIIMY----TRANPCIILKIVDGKLWFQLDCGSGPGILGISGR---AVNDG 3915

Query: 1526 RWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQ 1585
             WHSV ++     N   L L       + A +      T  ++ FG  +          Q
Sbjct: 3916 SWHSVFLEL--NRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALV----------Q 3963

Query: 1586 TGSKKSL-DLTGPLLLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTRE 1644
              + +SL D     +L G     +   ++N +       L +  K    A  +     + 
Sbjct: 3964 ADNIRSLTDTRVTQVLSGFQGCLDSVILNNNE-------LPLQNKRSSFAEVVGLTELKL 4016

Query: 1645 GCAARRNFCDGRRCQNGGTCVN-RWNMYLCECPLRFGGKNCE 1685
            GC    + C    CQ+GG+C       Y C C  +F G+NCE
Sbjct: 4017 GCVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCE 4058



 Score =  406 bits (1044), Expect = e-112
 Identities = 302/984 (30%), Positives = 480/984 (48%), Gaps = 71/984 (7%)

Query: 249  NYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTD 308
            +Y V + E+ P GT+I  L  H    G   +V Y +   ++    G F ID A+GA+   
Sbjct: 940  SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYN----GRFEIDKASGAIRLS 995

Query: 309  SVLDRETKETHVLRVKAVDYSTPPR-SATTYITVLVKDTND--HSPVFEQSEYRERVREN 365
              LD E ++ + L V+A D   P   S+ +++ V V D N+  H+P F        V+EN
Sbjct: 996  KELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKEN 1055

Query: 366  LEVGYEVLTIRASDRDSPINANLRYRVLGGAW-DVFQLNESSGVVSTRAVLDREEAAEYQ 424
              +G  VL + A D DS  +  ++Y +  G+    F +++ SGV++   +LDRE    Y 
Sbjct: 1056 SRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYW 1115

Query: 425  LLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQAT 484
            L V A D+G    PL +T  VYIEVED NDN P  SE  Y   V E+   + +V+++QA 
Sbjct: 1116 LTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAE 1173

Query: 485  DRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN-PLDFEDVQKYSLSIKAQDGGRPP 543
            D D   N  + Y I SGN    F ++  +G++   +  LD E   ++ L +   DGG  P
Sbjct: 1174 DPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSP 1233

Query: 544  LINSSGVVSVQVLDVNDNEPIFVSSPFQATVLEN--VPLGYPVVHIQAVDADSGENARLH 601
              ++  VV VQVLD NDN+P F    +Q  + E      G P+    A D D G NA + 
Sbjct: 1234 KQSTIWVV-VQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEIS 1292

Query: 602  YRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVD 661
            Y +VD                    D  F I   +G ++   +      +  +  ++AVD
Sbjct: 1293 YSIVDG-----------------NDDGKFFIDPKTGMVSSRKQFTAGSYDILT--IKAVD 1333

Query: 662  HGSPPMSSSTSVSITVLDVNDNDPV---FTQPTYELRLNEDAAVGSSVLTLQARDRDANS 718
            +G P  SS+  + I  +      P+   F +P Y   + E   V   V  +  +   AN+
Sbjct: 1334 NGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQP--ANT 1391

Query: 719  VITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLIN 778
             + + + GGN  + F   +++G G I +A PLD +Q   Y ++V  +DGT      V I 
Sbjct: 1392 PLWFDIVGGNFDSAF--DAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIK 1449

Query: 779  VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVP----- 833
            V D N + P F   +Y V++SED    T I  + A D D  E  +++Y +   +      
Sbjct: 1450 VLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD--EKHKLSYTVHSSIDSISMR 1507

Query: 834  QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
            +FRIDP +G +YT   LD+E Q  + L IM +D   P + +   + + + DAND++P F 
Sbjct: 1508 KFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFT 1567

Query: 894  WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ 953
               Y+ S+FE A   +++LQV+A D+D G N  L+YT + G+ G+  F IEP  G+I   
Sbjct: 1568 NPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGN-MFKIEPVLGIITIC 1626

Query: 954  RRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNP 1013
            +  D   +  + L     D+GSP P+SA+  +++++   +++ P F   + +  V EN  
Sbjct: 1627 KEPDMTTMGQFVLSIKVTDQGSP-PMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVD 1685

Query: 1014 VGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLV 1073
            +G+ V  I A        + ++Y++ +GD+   F ++  +G +     LD+E    Y L+
Sbjct: 1686 IGTSVILISAIS-----QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLI 1740

Query: 1074 VQATS-APLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIG------- 1125
            +QAT+ A + S ATV+I +VD+NDN PV      LF+ Y  + S + P   I        
Sbjct: 1741 IQATNMAGMASNATVNIQIVDENDNAPV-----FLFSQYSGSLSEAAPINSIVRSLDNSP 1795

Query: 1126 -CIPAHDPDVSDS--LNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
              I A D D + +  L Y  V+    +   +D +TG ++   +LD+         V V D
Sbjct: 1796 LVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRD 1855

Query: 1183 -GIHSVTAFCTLRVTIITDDMLTN 1205
             G   +TA   + V I   D+  N
Sbjct: 1856 SGSPQLTAESPVEVNIEVTDVNDN 1879



 Score =  390 bits (1001), Expect = e-107
 Identities = 302/976 (30%), Positives = 476/976 (48%), Gaps = 72/976 (7%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +F  PNY V + E+    T ILQ+ A  T   E+ ++SY +    D  S   FRID +TG
Sbjct: 1459 EFSQPNYDVTISEDVLPDTEILQIEA--TDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
             + T   LD E ++ H+L +   D   P R     + V V+D NDHSP F    Y   V 
Sbjct: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576

Query: 364  ENLEVGYEVLTIRASDRDSPINANLRYRV-LGGAWDVFQLNESSGVVSTRAVLDREEAAE 422
            E+  +G  VL + A D+D   NA L Y +  G   ++F++    G+++     D     +
Sbjct: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQ 1636

Query: 423  YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ 482
            + L ++  DQG    P+SATA V I V   ++++P+F  ++Y  +V E+V + T+V+ + 
Sbjct: 1637 FVLSIKVTDQG--SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILIS 1694

Query: 483  ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP 542
            A  +     + + Y +  G++ G F ++  SG++     LD+E    Y L I+A +    
Sbjct: 1695 AISQ-----STLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG- 1748

Query: 543  PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV-------VHIQAVDADSG 595
              + S+  V++Q++D NDN P+F+ S +  ++ E  P+   V       + I+A DADS 
Sbjct: 1749 --MASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSN 1806

Query: 596  ENARLHYRLVD-TASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
             NA L Y++V+ TA  F                  F + +S+G I   A LD E + H+ 
Sbjct: 1807 RNALLVYQIVESTAKKF------------------FTVDSSTGAIRTIANLDHETIAHFH 1848

Query: 655  FGVEAVDHGSPPMS--SSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQAR 712
            F V   D GSP ++  S   V+I V DVNDN PVFTQ  +E  L     VG  VL + A 
Sbjct: 1849 FHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSAT 1908

Query: 713  DRDAN--SVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRS 770
            D D+     +TY L  G+  + F + S  G     L +  +   +  Y+L V  SDG   
Sbjct: 1909 DPDSEVPPELTYSLMEGSL-DHFLIDSNSG----VLTIKNNNLSKDHYMLIVKVSDGKFY 1963

Query: 771  HTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD 830
             T+ V I V +A      F  S Y+ S+SE+    T +A ++A       N  + Y I +
Sbjct: 1964 STSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL--NEPLKYSILN 2021

Query: 831  PVPQFRIDPDSGTMYTM-MELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
            P  +F+I   SG + T  +  D E Q  Y L + A       +     + + I D NDN+
Sbjct: 2022 PGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNS 2081

Query: 890  PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG- 948
            P F+   Y  ++  DA P T I QV+A D+D GPNG + Y  Q   D  G F I P SG 
Sbjct: 2082 PVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQ---DDYGHFEINPNSGN 2138

Query: 949  -VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELF 1007
             +++     D  N+  Y +  LA D G P+ LS SVE+ +TI  +N   P+F+K      
Sbjct: 2139 VILKEAFNSDLSNIE-YGVTILAKDGGKPS-LSTSVELPITI--VNKAMPVFDKPFYTAS 2194

Query: 1008 VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVR 1067
            V E+  + + +  I A  P+      I+Y I++GD    F +D   G L+ +  LD+EV 
Sbjct: 2195 VNEDIRMNTPILSINATSPE---GQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVT 2251

Query: 1068 REYVLVVQATSAPLVSRA--TVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIG 1125
              Y L ++A+ A   +RA  TV +L+ D NDNPP+   F     N   ++++   T V+ 
Sbjct: 2252 SAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPI---FDQPTYNTTLSEASLIGTPVLQ 2308

Query: 1126 CIPAH-DPDVSDSLNYTFVQG--NELRLLLLDPATGELQLSRDLDNNRPLEALMEV-SVS 1181
             +    D + +  ++Y  VQ   N      +D ++G +  +R LD+       ++V S+ 
Sbjct: 2309 VVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSID 2368

Query: 1182 DGIHSVTAFCTLRVTI 1197
             G  S+++   + + I
Sbjct: 2369 SGFPSLSSEVLVHIYI 2384



 Score =  375 bits (963), Expect = e-103
 Identities = 278/969 (28%), Positives = 469/969 (48%), Gaps = 44/969 (4%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F    Y   + EN  AGT ++ + A     G   ++SY    + ++ ++  F IDS  G 
Sbjct: 2496 FSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISY---AIINDFAKDRFLIDS-NGQ 2551

Query: 305  VSTDSVLDRETK-ETHV-LRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
            V T   LDRE   E  V + V+A+D     R+    + V+V D ND++P F   EYR  V
Sbjct: 2552 VITTERLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASV 2609

Query: 363  RENLEVGYEVLTIRASDRDSPINANLRYRVLGGAW----DVFQLNESSGVVSTRAVLDRE 418
            R ++  G+ V  ++A D D   N+ + Y +   A     D+ +++  +G + T+   ++ 
Sbjct: 2610 RADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQL 2669

Query: 419  EAAEYQLLVEANDQGRNPGPLS-ATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTA 477
            +       V+A D G    P+  +   VYI V       P F++  Y   + ED  + + 
Sbjct: 2670 KNTVLSFFVKAVDGGI---PVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726

Query: 478  VLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQ 537
            V  ++         + ++      N  G F +   +G + +   LD E    +   + A 
Sbjct: 2727 VDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786

Query: 538  DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597
                   I  +  V ++VLD+NDN+P+F +S +   ++E +P+G  +  ++A+D D G N
Sbjct: 2787 IPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGAN 2846

Query: 598  ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGV 657
             ++ Y L   +             P    +  F I +++GWI+   +LD E    ++F V
Sbjct: 2847 GQVTYSLHSDSQ------------PEKVME-AFNIDSNTGWISTLKDLDHETDPTFTFSV 2893

Query: 658  EAVDHGSP-PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA 716
             A D G    +SS+  VS+ V D+NDN PVF Q  Y   + E    G  V  L   DRD 
Sbjct: 2894 VASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDT 2953

Query: 717  NSV---ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTA 773
            + V   ++Y +TGGN R RFAL   +    + +  PLD +++  Y L +TA+DG     A
Sbjct: 2954 SDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQA 3013

Query: 774  HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPV- 832
             V ++V+D N + PV     YT  + ED P    I  +SA D D G N  I Y +     
Sbjct: 3014 MVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGN 3073

Query: 833  PQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
             +F +DP+SG + T+  LD E    Y+L   A D G   +   + + +++ D NDN P F
Sbjct: 3074 SEFFLDPESGELKTLALLDRERIPVYSLMAKATDGG--GRFCQSNIHLILEDVNDNPPVF 3131

Query: 893  LWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRT 952
              D Y   ++E+      + +V A D D G N +++Y+    D   G F I+ +SG+I  
Sbjct: 3132 SSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSL--ADSAGGVFSIDSSSGIIIL 3189

Query: 953  QRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENN 1012
            ++ LDRE  + YN+   A D+     LS+   + +T+LDINDN P+FE+ +  + V E+ 
Sbjct: 3190 EQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDT 3249

Query: 1013 PVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVL 1072
              G+ V  + A   D G NA+I Y I  G+ +  F+++   G +     LD+E+ + + L
Sbjct: 3250 SPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYL 3309

Query: 1073 VVQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPA 1129
            VV+A    +  L + ATV+I L D NDNPP     Q +++  ++  +    + ++     
Sbjct: 3310 VVEAKDGGTPALSAVATVNINLTDVNDNPPKFS--QDVYSAVISEDALVGDSVILLIAED 3367

Query: 1130 HDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPL-EALMEVSVSDGIHSVT 1188
             D   +  ++++ V G+      +DP  G +++ + LD  R    +L+  +V  GI +++
Sbjct: 3368 VDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMS 3427

Query: 1189 AFCTLRVTI 1197
            +  T+ + I
Sbjct: 3428 STATVNIDI 3436



 Score =  372 bits (956), Expect = e-102
 Identities = 291/973 (29%), Positives = 469/973 (48%), Gaps = 74/973 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F  P Y+ ++FE+   G+ +LQ+ A    +GE   + Y +E      +   F+I+   G 
Sbjct: 1566 FTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEA---GNTGNMFKIEPVLGI 1622

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
            ++     D  T    VL +K  D  +PP SAT  + + V  +++  P F   +Y+  V E
Sbjct: 1623 ITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNE 1682

Query: 365  NLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEY 423
            N+++G  V+ I A  +     + L Y V  G  + +F +N  SGV++T+  LD E  + Y
Sbjct: 1683 NVDIGTSVILISAISQ-----STLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSY 1737

Query: 424  QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV----- 478
            QL+++A     N   +++ ATV I++ DENDN P F    Y   + E   +N+ V     
Sbjct: 1738 QLIIQAT----NMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDN 1793

Query: 479  --LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKA 536
              L ++ATD D  +NA + Y I+       F + S +G +  I  LD E +  +   +  
Sbjct: 1794 SPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHV 1853

Query: 537  QDGGRPPLINSSGV-VSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
            +D G P L   S V V+++V DVNDN P+F  + F+  +L    +G  V+ + A D DS 
Sbjct: 1854 RDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSE 1913

Query: 596  ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSF 655
                L Y L++        GS             F I ++SG +T+  + +    +HY  
Sbjct: 1914 VPPELTYSLME--------GSLD----------HFLIDSNSGVLTI--KNNNLSKDHYML 1953

Query: 656  GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
             V+  D       S++ V+I V +  D+   FTQ  Y   ++E+    + V  + A    
Sbjct: 1954 IVKVSD---GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNR 2010

Query: 716  ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTAS---DGTRSHT 772
             N  + Y +   N  N+F + S   G + T  +P D ++++ Y L V AS   D  R   
Sbjct: 2011 LNEPLKYSIL--NPGNKFKIKS-TSGVIQTTGVPFDREEQELYELVVEASRELDHLRVAR 2067

Query: 773  AHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPV 832
              V +N+ D N + PVF    Y  +V  D   GT I  ++A D+D G N  +TYV+QD  
Sbjct: 2068 VVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDY 2127

Query: 833  PQFRIDPDSGTMYTMMELDYE-NQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891
              F I+P+SG +      + + + + Y +TI+A+D G P  S  T++E+ I   N   P 
Sbjct: 2128 GHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLS--TSVELPITIVNKAMPV 2185

Query: 892  FLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGR-LLYTFQGGDDGDGDFYIEPTSGVI 950
            F   FY  S+ ED   +T IL ++AT     P G+ ++Y    GD     F I+  +GV+
Sbjct: 2186 FDKPFYTASVNEDIRMNTPILSINAT----SPEGQGIIYIIIDGDPFK-QFNIDFDTGVL 2240

Query: 951  RTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEE 1010
            +    LD E  + Y L   A D  + T   A V + + + D+NDN P+F++      + E
Sbjct: 2241 KVVSPLDYEVTSAYKLTIRASD--ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSE 2298

Query: 1011 NNPVGSVVAKIRANDPDEGPNAQIMYQIVEG--DMRHFFQLDLLNGDLRAMVELDFEVRR 1068
             + +G+ V ++ + D D   N  + YQIV+   +   +F +D  +G +     LD E+ +
Sbjct: 2299 ASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQ 2358

Query: 1069 EYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VI 1124
               L V++  +    L S   VHI + D NDNPPV    Q+++ +YV   S   P G  +
Sbjct: 2359 HCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFN--QLIYESYV---SELAPRGHFV 2413

Query: 1125 GCIPAHDPDVS--DSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
             C+ A D D S  D L Y+ + GN+    L+D  +G + LS            + VSVSD
Sbjct: 2414 TCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD 2473

Query: 1183 GIHSVTAFCTLRV 1195
            G+ + TA   +RV
Sbjct: 2474 GLFTSTAQVHIRV 2486



 Score =  371 bits (953), Expect = e-102
 Identities = 295/978 (30%), Positives = 460/978 (47%), Gaps = 102/978 (10%)

Query: 243  LKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSAT 302
            ++F    Y V++ E  P G ++    A   +  E   V Y +    D     YF+I+  +
Sbjct: 374  IRFEKEVYDVSISEFSPPGVVV----AIVKLSPEPIDVEYKLSPGEDAV---YFKINPRS 426

Query: 303  GAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
            G + T   L+   KE + L V     +         +T+ ++D NDH+P F+Q  Y   V
Sbjct: 427  GLIVTARPLNTVKKEVYKLEV-----TNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYV 481

Query: 363  RENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAE 422
             E++ VG  VLT+ ASD+D   N  + Y +       F +N+ +GV+ST   LD E + E
Sbjct: 482  NESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPE 541

Query: 423  -YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRV 481
             Y+ +V A+D G +P    +   V I + + NDN P F +      +  D  +   +  V
Sbjct: 542  IYRFIVRASDWG-SPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAV 600

Query: 482  QATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQK--YSLSIKAQDG 539
             A D D+ +   + Y I+SGN  G FYL+  SG+L +   L    ++   ++L I A DG
Sbjct: 601  SAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDG 658

Query: 540  GR---PPLINSS---GVVS-----------------------------------VQVLDV 558
                 P  IN S   G VS                                   +    +
Sbjct: 659  ENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSI 718

Query: 559  NDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSA 617
            N   P F  S P    V E++P+G  ++ I+A DADSG N ++ + + D           
Sbjct: 719  NRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISD----------- 767

Query: 618  GPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITV 677
                     D  F I   +G + V   +DRE  + Y   +   D G+P  SS   ++I V
Sbjct: 768  ------GNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINV 821

Query: 678  LDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRFAL 735
             D NDN PVF Q +Y + + E + +G+ ++ ++ARD+D  +N  +TY +       +FA+
Sbjct: 822  EDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAI 879

Query: 736  SSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRS-----HTAHVLINVTDANTHRPVFQ 790
            +S    G++ +A  LD + +  Y L + A D   S         + + + D N   P F 
Sbjct: 880  NSST--GIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFI 937

Query: 791  SSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRIDPDSGTMYTMME 849
             S Y+V V ED PVGT IA L  +D D G   ++ Y ++ D   +F ID  SG +    E
Sbjct: 938  PSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKE 997

Query: 850  LDYENQVAYTLTIMAQDNGIP-QKSDTTTLEILILDANDN--APQFLWDFYQGSIFEDAP 906
            LDYE Q  Y LT+ A+D G P   S  + +E+ ++D N+N   P F      GS+ E++ 
Sbjct: 998  LDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSR 1057

Query: 907  PSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNL 966
              TS+LQV+A D DSG +G + Y+ + G  G G F I+  SGVI     LDRE +  Y L
Sbjct: 1058 IGTSVLQVTARDEDSGRDGEIQYSIRDG-SGLGRFSIDDESGVITAADILDRETMGSYWL 1116

Query: 967  WALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDP 1026
               A DRG   PL +++E+ + + D+NDNAP+  +      V EN+P    V +I+A DP
Sbjct: 1117 TVYATDRG-VVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDP 1175

Query: 1027 DEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMV-ELDFEVRREYVLVVQATS---APLV 1082
            D   N ++ Y+I  G+ ++FF +++  G +     +LD E + E+ L V  T    +P  
Sbjct: 1176 DSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ 1235

Query: 1083 SRATVHILLVDQNDNPPVLPD--FQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNY 1140
            S   V + ++D+NDN P  P+  +QI        K                P+    ++Y
Sbjct: 1236 STIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNA--EISY 1293

Query: 1141 TFVQGNELRLLLLDPATG 1158
            + V GN+     +DP TG
Sbjct: 1294 SIVDGNDDGKFFIDPKTG 1311



 Score =  365 bits (938), Expect = e-100
 Identities = 288/853 (33%), Positives = 419/853 (49%), Gaps = 63/853 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFD-ERSRGYFRIDSATG 303
            F   +Y   + E  P GT + Q+ A     G   +V+Y +      E+    F IDS TG
Sbjct: 2814 FETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTG 2873

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTP-PRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
             +ST   LD ET  T    V A D       S+T  ++V V D ND++PVF Q  YR  V
Sbjct: 2874 WISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNV 2933

Query: 363  RENLEVGYEVLTIRASDRD-SPINANLRYRVLGG---AWDVFQLNESSGVVSTRAVLDRE 418
            +E+   G  V  +   DRD S +N  + Y + GG         L +S   V  +  LDRE
Sbjct: 2934 KESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE 2993

Query: 419  EAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
            E   Y L + A D     G     A V + V D NDN P   +  Y   +PED+  N  +
Sbjct: 2994 EQDIYFLNITATD-----GLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKII 3048

Query: 479  LRVQATDRDQGQNAAIHYSIL-SGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQ 537
            L+V A D D G N  I YS+  SGN   +F+L   SG L  +  LD E +  YSL  KA 
Sbjct: 3049 LKVSAKDADIGSNGYIRYSLYGSGN--SEFFLDPESGELKTLALLDRERIPVYSLMAKAT 3106

Query: 538  DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597
            DGG     ++  ++   + DVNDN P+F S  +   V EN      +  +QAVD D G N
Sbjct: 3107 DGGGRFCQSNIHLI---LEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGIN 3163

Query: 598  ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGV 657
             ++ Y L D+A     GG              F I +SSG I +   LDRE+   Y+  V
Sbjct: 3164 RKVVYSLADSA-----GGV-------------FSIDSSSGIIILEQPLDREQQSSYNISV 3205

Query: 658  EAVDHG-SPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD- 715
             A D      +SS T+V+ITVLD+NDN PVF +  Y + + ED + G+ VL + A  +D 
Sbjct: 3206 RATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDI 3265

Query: 716  -ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSH 771
              N+ ITY +  GN + +F ++ + GG  I+++  LDY+  +++ L V A DG     S 
Sbjct: 3266 GTNAEITYLIRSGNEQGKFKINPKTGG--ISVSEVLDYELCKRFYLVVEAKDGGTPALSA 3323

Query: 772  TAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ-- 829
             A V IN+TD N + P F    Y+  +SED  VG S+  L A D D+  N +I + I   
Sbjct: 3324 VATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNG 3383

Query: 830  DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
            D   +F +DP  G +    +LD E    Y+L + A D+GIP  S T T+ I I D NDN+
Sbjct: 3384 DRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNS 3443

Query: 890  PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNG-RLLYTFQGGDDGDGDFYIEPTSG 948
            P F    Y   I E+ P  TSILQ+  TDRDS  NG    ++   G++ + +F ++P  G
Sbjct: 3444 PVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNE-EEEFVLDP-HG 3501

Query: 949  VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFV 1008
            ++R+           Y L   A D G P  +S +  I+V +++ + + P     E+ +  
Sbjct: 3502 ILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-IRVRVIEESTHKPTAIPLEIFIVT 3560

Query: 1009 EENNPVGSVVAKIRANDPDEGPNAQIMYQI----VEGDMRHFFQLDLLNGDLRAMVELDF 1064
             E++  G V+ KI A D D       MY +    ++ + +  F+++  +G + A+  LD 
Sbjct: 3561 MEDDFPGGVIGKIHATDQD-------MYDVLTFALKSEQKSLFKVNSHDGKIIALGGLD- 3612

Query: 1065 EVRREYVLVVQAT 1077
                +YVL V  +
Sbjct: 3613 --SGKYVLNVSVS 3623



 Score =  359 bits (921), Expect = 3e-98
 Identities = 285/978 (29%), Positives = 469/978 (47%), Gaps = 73/978 (7%)

Query: 252  VALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVL 311
            VA+ E+ P G  IL++ A+    G   +V + +    D  +   F ID  TG +     +
Sbjct: 733  VAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS---DGNTDSCFNIDMETGQLKVLMPM 789

Query: 312  DRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYE 371
            DRE  + ++L +   D   P +S+   +T+ V+D ND+SPVF Q  Y   + E+  +G E
Sbjct: 790  DREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTE 849

Query: 372  VLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEAND 431
            ++ + A D+D   N  + Y VL      F +N S+G+V     LDRE  A Y L +EA D
Sbjct: 850  IIQVEARDKDLGSNGEVTYSVLTDT-QQFAINSSTGIVYVADQLDRESKANYSLKIEARD 908

Query: 432  QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
            +  +   L +  T+ + ++D ND  P F   +Y V+V ED+ + T +  ++  D D G  
Sbjct: 909  KAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLG 968

Query: 492  AAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVV 551
              + YS+++ +  G+F +   SG + +   LD+E  Q Y+L+++A+D GRP  ++S   V
Sbjct: 969  GQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFV 1027

Query: 552  SVQVLDVNDN--EPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
             V+V+DVN+N   P F       +V EN  +G  V+ + A D DSG +  + Y + D   
Sbjct: 1028 EVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRD--- 1084

Query: 610  TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
                G   G           F I + SG IT    LDRE +  Y   V A D G  P+ S
Sbjct: 1085 ----GSGLG----------RFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYS 1130

Query: 670  STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGG 727
            +  V I V DVNDN P+ ++P Y   + E++    SV+ +QA D D  +N  +TY++T G
Sbjct: 1131 TIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSG 1190

Query: 728  NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANT 784
            N +N FA++  + G + T +  LD +Q+ ++ L VT +DG    +  T  V++ V D N 
Sbjct: 1191 NPQNFFAINI-KTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDEND 1249

Query: 785  HRPVFQSSHYTVSVSE-DRPV-GTSIATLSANDEDTGENARITYVIQD--PVPQFRIDPD 840
            ++P F    Y + + E DR   G  I    A D D G NA I+Y I D     +F IDP 
Sbjct: 1250 NKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPK 1309

Query: 841  SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAP---QFLWDFY 897
            +G + +  +    +     LTI A DNG PQKS T  L I  +     +P    F   FY
Sbjct: 1310 TGMVSSRKQFTAGSY--DILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFY 1367

Query: 898  QGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD 957
              ++ E    S  + ++         N  L +   GG + D  F  E   G I   + LD
Sbjct: 1368 NFTVME----SDRVTEIVGVVSVQPANTPLWFDIVGG-NFDSAFDAEKGVGTIVIAKPLD 1422

Query: 958  RENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSV 1017
             E  ++YN+ ++ V  G+     A  ++ + +LD NDN P F +   ++ + E+    + 
Sbjct: 1423 AEQRSIYNM-SVEVTDGTNV---AVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTE 1478

Query: 1018 VAKIRANDPDEGPN-AQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA 1076
            + +I A D DE    +  ++  ++      F++D   G L     LD E + +++L +  
Sbjct: 1479 ILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMV 1538

Query: 1077 TSAPLVSR---ATVHILLVDQNDNPPVLPDFQILFNNYVTN---KSNSFPTGVIGC---- 1126
                   R   A V + + D ND+ P           Y TN   +++ F +  +G     
Sbjct: 1539 RDQEFPYRRNLARVIVNVEDANDHSP-----------YFTNPLYEASVFESAALGSAVLQ 1587

Query: 1127 IPAHDPDVSDS--LNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-G 1183
            + A D D  ++  L YT   GN   +  ++P  G + + ++ D     + ++ + V+D G
Sbjct: 1588 VTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647

Query: 1184 IHSVTAFCTLRVTIITDD 1201
               ++A   +R+++   D
Sbjct: 1648 SPPMSATAIVRISVTMSD 1665



 Score =  354 bits (909), Expect = 6e-97
 Identities = 286/985 (29%), Positives = 457/985 (46%), Gaps = 75/985 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F  P Y   L E    GT +LQ+      + E  ++ +Y        S  YF IDS++G 
Sbjct: 2287 FDQPTYNTTLSEASLIGTPVLQV-VSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGL 2345

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
            + T  +LD E  +   L+V+++D   P  S+   + + + D ND+ PVF Q  Y   V E
Sbjct: 2346 ILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSE 2405

Query: 365  NLEVGYEVLTIRASDRDSPINANLRYRVL-GGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
                G+ V  ++ASD DS     L Y +L G     F ++  SGV++      +     Y
Sbjct: 2406 LAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLY 2465

Query: 424  QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQA 483
             L V  +D     G  ++TA V+I V   N   P FS+  YV +V E+V   T V+ V+A
Sbjct: 2466 SLNVSVSD-----GLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRA 2520

Query: 484  TDRDQGQNAAIHYSILSGNVAGQFYLHSLSGI-----LDVINPLDFEDVQKYSLSIKAQD 538
            TD D G    I Y+I++     +F + S   +     LD  NPL+ +     S+ ++A D
Sbjct: 2521 TDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGD----VSIFVRALD 2576

Query: 539  GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
            GG      +   V V V+D NDN P F++  ++A+V  +V  G+ V  +QA+D D G N+
Sbjct: 2577 GGGR---TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANS 2633

Query: 599  RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658
            R+ Y L   AS  +                  +I   +GW+      ++ +    SF V+
Sbjct: 2634 RITYSLYSEASVSVAD--------------LLEIDPDNGWMVTKGNFNQLKNTVLSFFVK 2679

Query: 659  AVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANS 718
            AVD G P   S   V I VL      P FTQ  Y   + ED A+GS+V TL+        
Sbjct: 2680 AVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLR-------- 2731

Query: 719  VITYQLTGGNTRNRFALSSQRGG--------GLITLALPLDYKQEQQYVLAVTASDGTRS 770
            ++  Q    +T N     + +GG        G I L   LD +    +   V A+     
Sbjct: 2732 ILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDK 2791

Query: 771  ----HTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY 826
                 T  V I V D N ++PVF++S Y   + E  PVGT +  + A D D G N ++TY
Sbjct: 2792 VDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTY 2851

Query: 827  VI-QDPVPQ-----FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP-QKSDTTTLE 879
             +  D  P+     F ID ++G + T+ +LD+E    +T +++A D G     S T  + 
Sbjct: 2852 SLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVS 2911

Query: 880  ILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRD-SGPNGRLLYTFQGGDD-G 937
            + + D NDNAP F  + Y+G++ E  PP   +  +S  DRD S  N ++ Y   GG+  G
Sbjct: 2912 VRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRG 2971

Query: 938  DGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAP 997
                 +  +   +  +R LDRE   +Y L   A D    T       ++V++ D+NDN+P
Sbjct: 2972 RFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVT----QAMVEVSVSDVNDNSP 3027

Query: 998  MFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLR 1057
            + ++      + E+ P   ++ K+ A D D G N  I Y +       FF LD  +G+L+
Sbjct: 3028 VCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELK 3086

Query: 1058 AMVELDFEVRREYVLVVQAT-SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKS 1116
             +  LD E    Y L+ +AT       ++ +H++L D NDNPPV       +N  V    
Sbjct: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDH--YNTCV--YE 3142

Query: 1117 NSFPTGVIGCIPAHDPDVSDSLNYTFVQGNEL-RLLLLDPATGELQLSRDLDNNRPLEAL 1175
            N+    ++  + A DPD+  +    +   +    +  +D ++G + L + LD  +     
Sbjct: 3143 NTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYN 3202

Query: 1176 MEVSVSDGI--HSVTAFCTLRVTII 1198
            + V  +D     S+++  T+ +T++
Sbjct: 3203 ISVRATDQSPGQSLSSLTTVTITVL 3227



 Score =  335 bits (860), Expect = 3e-91
 Identities = 279/935 (29%), Positives = 433/935 (46%), Gaps = 69/935 (7%)

Query: 296  FRIDSATGAVSTDSV-LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
            F+I S +G + T  V  DRE +E + L V+A       R A   + V ++D ND+SPVF 
Sbjct: 2026 FKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFV 2085

Query: 355  QSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAV 414
               Y   V+ + E G  +  + A D+D   N  + Y VL   +  F++N +SG V  +  
Sbjct: 2086 GLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEA 2144

Query: 415  LDREEA-AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVG 473
             + + +  EY + + A D G+     S + +V + +   N   P F +  Y   V ED+ 
Sbjct: 2145 FNSDLSNIEYGVTILAKDGGKP----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIR 2200

Query: 474  LNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
            +NT +L + AT   +GQ   I Y I+ G+   QF +   +G+L V++PLD+E    Y L+
Sbjct: 2201 MNTPILSINATS-PEGQG--IIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLT 2257

Query: 534  IKAQDGGRPPLINSSGVVSVQVL--DVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVD 591
            I+A D     L  +   V+V +L  DVNDN PIF    +  T+ E   +G PV+ + ++D
Sbjct: 2258 IRASDA----LTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSID 2313

Query: 592  ADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVE 651
            ADS  N  +HY++V                   + D+ F I +SSG I     LD E V+
Sbjct: 2314 ADSENNKMVHYQIVQDTYN--------------STDY-FHIDSSSGLILTARMLDHELVQ 2358

Query: 652  HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA 711
            H +  V ++D G P +SS   V I + DVNDN PVF Q  YE  ++E A  G  V  +QA
Sbjct: 2359 HCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQA 2418

Query: 712  RDRDANSV--ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR 769
             D D++    + Y +  GN R  F + S+   G+ITL+     + E  Y L V+ SDG  
Sbjct: 2419 SDADSSDFDRLEYSILSGNDRTSFLMDSK--SGVITLSNHRKQRMEPLYSLNVSVSDGLF 2476

Query: 770  SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
            + TA V I V  AN + P F  S Y   V E+   GT +  + A D D G   +I+Y I 
Sbjct: 2477 TSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAII 2536

Query: 830  DPVPQFRIDPDS-GTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDN 888
            +   + R   DS G + T   LD EN +   ++I  +      ++   T+ ++++D NDN
Sbjct: 2537 NDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDN 2596

Query: 889  APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYT-FQGGDDGDGDFY-IEPT 946
            APQF+   Y+ S+  D      + QV A D D G N R+ Y+ +        D   I+P 
Sbjct: 2597 APQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPD 2656

Query: 947  SGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL 1006
            +G + T+   ++    V + +  AVD G P   S  + + + +L      P F + +   
Sbjct: 2657 NGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSL-IPVYIHVLPPETFLPSFTQSQYSF 2715

Query: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRH-----FFQLDLLNGDLRAMVE 1061
             + E+  +GS V  +R       P+  + +  V G+         F ++   G ++    
Sbjct: 2716 TIAEDTAIGSTVDTLRIL-----PSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKR 2770

Query: 1062 LDFEVRREYVLVVQAT----SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSN 1117
            LD E    +   V AT       +V    V I ++D NDN PV        ++Y T    
Sbjct: 2771 LDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFET-----SSYDTIIME 2825

Query: 1118 SFPTGV-IGCIPAHDPD------VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNR 1170
              P G  +  + A D D      V+ SL+        +    +D  TG +   +DLD+  
Sbjct: 2826 GMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHET 2885

Query: 1171 PLEALMEVSVSD----GIHSVTAFCTLRVTIITDD 1201
                   V  SD       S TA  ++RVT I D+
Sbjct: 2886 DPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDN 2920



 Score =  333 bits (855), Expect = 1e-90
 Identities = 294/1022 (28%), Positives = 449/1022 (43%), Gaps = 61/1022 (5%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +F    Y+ ++  +   G L+ Q+ A    +G   R++Y +             ID   G
Sbjct: 2599 QFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNG 2658

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
             + T    ++         VKAVD   P + +   + + V       P F QS+Y   + 
Sbjct: 2659 WMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIA 2718

Query: 364  ENLEVGYEVLTIRASDRD----SPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREE 419
            E+  +G  V T+R         S +N        GG   +F + + +G +     LDRE 
Sbjct: 2719 EDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGG---IFVIEQETGTIKLDKRLDRET 2775

Query: 420  AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVL 479
            +  +   V A     +   +  T  V I+V D NDN P F   +Y   + E + + T + 
Sbjct: 2776 SPAFHFKVAATIP-LDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLT 2834

Query: 480  RVQATDRDQGQNAAIHYSILSGN----VAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
            +V+A D D G N  + YS+ S +    V   F + S +G +  +  LD E    ++ S+ 
Sbjct: 2835 QVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVV 2894

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
            A D G    ++S+ +VSV+V D+NDN P+F    ++  V E+ P G  V  +   D D+ 
Sbjct: 2895 ASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTS 2954

Query: 596  E-NARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
            + N ++ Y +         GG+       P   F   +  S   + V   LDREE + Y 
Sbjct: 2955 DVNRQVSYHIT--------GGN-------PRGRFALGLVQSEWKVYVKRPLDREEQDIYF 2999

Query: 655  FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
              + A D       +   V ++V DVNDN PV  Q  Y   L ED      +L + A+D 
Sbjct: 3000 LNITATDG---LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDA 3056

Query: 715  D--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-RSH 771
            D  +N  I Y L G      F       G L TLAL LD ++   Y L   A+DG  R  
Sbjct: 3057 DIGSNGYIRYSLYGSGNSEFFL--DPESGELKTLAL-LDRERIPVYSLMAKATDGGGRFC 3113

Query: 772  TAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDP 831
             +++ + + D N + PVF S HY   V E+      +  + A D D G N ++ Y + D 
Sbjct: 3114 QSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADS 3173

Query: 832  VPQ-FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK-SDTTTLEILILDANDNA 889
                F ID  SG +     LD E Q +Y +++ A D    Q  S  TT+ I +LD NDN 
Sbjct: 3174 AGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNP 3233

Query: 890  PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
            P F    Y  ++ ED  P T +L V AT +D G N  + Y  + G++  G F I P +G 
Sbjct: 3234 PVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNE-QGKFKINPKTGG 3292

Query: 950  IRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVE 1009
            I     LD E    + L   A D G+P  LSA   + + + D+NDN P F +D     + 
Sbjct: 3293 ISVSEVLDYELCKRFYLVVEAKDGGTPA-LSAVATVNINLTDVNDNPPKFSQDVYSAVIS 3351

Query: 1010 ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE 1069
            E+  VG  V  + A D D  PN QI + IV GD  + F +D + G ++   +LD E    
Sbjct: 3352 EDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSG 3411

Query: 1070 YVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGV-IG 1125
            Y L+VQA  +    + S ATV+I + D NDN PV         NY      + P G  I 
Sbjct: 3412 YSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTP-----ANYTAVIQENKPVGTSIL 3466

Query: 1126 CIPAHDPDV---SDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
             +   D D        +++ + GNE    +LDP  G L+ +    +   LE ++ V   D
Sbjct: 3467 QLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDP-HGILRSAVVFQHTESLEYVLCVQAKD 3525

Query: 1183 -GIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDD 1241
             G     +   +RV +I +       T +   +  E F+  +   F  GV   +  T  D
Sbjct: 3526 SGKPQQVSHTYIRVRVIEES------THKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQD 3579

Query: 1242 VF 1243
            ++
Sbjct: 3580 MY 3581



 Score =  327 bits (839), Expect = 8e-89
 Identities = 279/948 (29%), Positives = 437/948 (46%), Gaps = 67/948 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F   +Y V + E+   GT I+Q+ A     G    V+Y +  L D +    F I+S+TG 
Sbjct: 831  FIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSV--LTDTQQ---FAINSSTGI 885

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYIT--VLVKDTNDHSPVFEQSEYRERV 362
            V     LDRE+K  + L+++A D +   +   + +T  V + D ND SP F  S Y  +V
Sbjct: 886  VYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKV 945

Query: 363  RENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAE 422
             E+L VG  +  +   D D  +   +RY ++      F+++++SG +     LD E+   
Sbjct: 946  LEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQF 1005

Query: 423  YQLLVEANDQGRNPGPLSATATVYIEVEDENDNY--PQFSEQNYVVQVPEDVGLNTAVLR 480
            Y L V A D+GR P  LS+ + V +EV D N+N   P F +   V  V E+  + T+VL+
Sbjct: 1006 YNLTVRAKDKGR-PVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQ 1064

Query: 481  VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG 540
            V A D D G++  I YSI  G+  G+F +   SG++   + LD E +  Y L++ A D G
Sbjct: 1065 VTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRG 1124

Query: 541  RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARL 600
              PL  S+  V ++V DVNDN P+     +   V+EN P    V+ IQA D DS  N +L
Sbjct: 1125 VVPLY-STIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKL 1183

Query: 601  HYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCA-ELDREEVEHYSFGVEA 659
             YR+           S  P+N        F I+  +G IT  + +LDRE+   +   V  
Sbjct: 1184 TYRIT----------SGNPQN-------FFAINIKTGLITTTSRKLDREQQAEHFLEVTV 1226

Query: 660  VDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNE--DAAVGSSVLTLQARDRD-- 715
             D G  P  S+  V + VLD NDN P F +  Y+++L E      G  +    A DRD  
Sbjct: 1227 TDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEG 1286

Query: 716  ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR---SHT 772
             N+ I+Y +  GN   +F +  + G     ++    +      +L + A D  R   S T
Sbjct: 1287 PNAEISYSIVDGNDDGKFFIDPKTG----MVSSRKQFTAGSYDILTIKAVDNGRPQKSST 1342

Query: 773  AHVLINVTDANTHRPV---FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
            A + I         P+   F    Y  +V E   V   +  +S    +T     I     
Sbjct: 1343 ARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNF 1402

Query: 830  DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
            D    F  +   GT+     LD E +  Y +++   D         T + I +LD NDN 
Sbjct: 1403 DSA--FDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDG---TNVAVTQVFIKVLDNNDNG 1457

Query: 890  PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG--DFYIEPTS 947
            P+F    Y  +I ED  P T ILQ+ ATDRD     +L YT     D      F I+P++
Sbjct: 1458 PEFSQPNYDVTISEDVLPDTEILQIEATDRDE--KHKLSYTVHSSIDSISMRKFRIDPST 1515

Query: 948  GVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELF 1007
            GV+ T  RLD E    + L  +  D+  P   + +  + V + D ND++P F     E  
Sbjct: 1516 GVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLA-RVIVNVEDANDHSPYFTNPLYEAS 1574

Query: 1008 VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVR 1067
            V E+  +GS V ++ A D D+G NA+++Y I  G+  + F+++ + G +    E D    
Sbjct: 1575 VFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTM 1634

Query: 1068 REYVLVVQAT---SAPLVSRATVHILLVDQNDNPP--VLPDFQILFNNYVTNKSNSFPTG 1122
             ++VL ++ T   S P+ + A V I +   +++ P  +  D+Q   N  V   ++     
Sbjct: 1635 GQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILIS 1694

Query: 1123 VIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNR 1170
             I            +L Y    G+   +  ++P +G +   + LD  R
Sbjct: 1695 AIS---------QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYER 1733



 Score =  321 bits (822), Expect = 8e-87
 Identities = 258/929 (27%), Positives = 426/929 (45%), Gaps = 108/929 (11%)

Query: 321  LRVKAVDYSTPPRSATTYITVLVKDTNDHSPV-FEQSEYRERVRENLEVGYEVLTIRASD 379
            L ++A D  +P + +      +   T D  P+ FE+  Y   + E    G  V  ++ S 
Sbjct: 343  LTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLS- 401

Query: 380  RDSPINANLRYRVLGGAWDV-FQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGP 438
               P   ++ Y++  G   V F++N  SG++ T   L+  +   Y+L V   +     G 
Sbjct: 402  ---PEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKE-----GD 453

Query: 439  LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI 498
            L A  T  I +ED ND+ P+F +  Y   V E V + T+VL V A+D+D+G+N  I YSI
Sbjct: 454  LKAQVT--ISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSI 511

Query: 499  LSGNVAGQFYLHSLSGILDVINPLDFEDVQK-YSLSIKAQDGGRPPLINSSGVVSVQVLD 557
             S N+   F ++  +G++     LDFE   + Y   ++A D G P    S   V++++ +
Sbjct: 512  ASLNLL-PFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGN 570

Query: 558  VNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSA 617
            VNDN P+F     Q  +  + P+G  +  + A+D D  E  +  Y+++        G   
Sbjct: 571  VNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVK--YKIIS-------GNEL 621

Query: 618  GPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITV 677
            G           F ++  SG + +   L    +++ +F +         ++   S++I+V
Sbjct: 622  GF----------FYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671

Query: 678  L--------------------------------------------DVNDNDPVFTQP-TY 692
            L                                             +N   P F +    
Sbjct: 672  LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731

Query: 693  ELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPL 750
            ++ + ED  VG+++L ++A D D+  N  + + ++ GNT + F +  + G   + + +P+
Sbjct: 732  DVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQ--LKVLMPM 789

Query: 751  DYKQEQQYVLAVTASD---GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTS 807
            D +    Y+L +T  D     +S    + INV DAN + PVF    Y+V++ E   +GT 
Sbjct: 790  DREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTE 849

Query: 808  IATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDN 867
            I  + A D+D G N  +TY +     QF I+  +G +Y   +LD E++  Y+L I A+D 
Sbjct: 850  IIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDK 909

Query: 868  GI--PQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNG 925
                 Q     TL++ + D ND +P F+   Y   + ED P  T I  +   D D G  G
Sbjct: 910  AESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGG 969

Query: 926  RLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEI 985
            ++ Y+    +D +G F I+  SG IR  + LD E    YNL   A D+G P  LS+   +
Sbjct: 970  QVRYSLV--NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFV 1027

Query: 986  QVTILDINDN--APMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDM 1043
            +V ++D+N+N   P F    +   V+EN+ +G+ V ++ A D D G + +I Y I +G  
Sbjct: 1028 EVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSG 1087

Query: 1044 RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATS---APLVSRATVHILLVDQNDNPPV 1100
               F +D  +G + A   LD E    Y L V AT     PL S   V+I + D NDN P+
Sbjct: 1088 LGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPL 1147

Query: 1101 LPD---FQILFNNYVTNKSNSFPTGVIGCIPAHDPDVS--DSLNYTFVQGNELRLLLLDP 1155
              +   + ++  N   + S       +  I A DPD S  + L Y    GN      ++ 
Sbjct: 1148 TSEPIYYPVVMENSPKDVS-------VIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINI 1200

Query: 1156 ATGEL-QLSRDLDNNRPLEALMEVSVSDG 1183
             TG +   SR LD  +  E  +EV+V+DG
Sbjct: 1201 KTGLITTTSRKLDREQQAEHFLEVTVTDG 1229



 Score =  310 bits (794), Expect = 1e-83
 Identities = 274/979 (27%), Positives = 449/979 (45%), Gaps = 97/979 (9%)

Query: 248  PNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVST 307
            P Y   + EN P    ++Q+ A        E+++Y    +     + +F I+  TG ++T
Sbjct: 1151 PIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTY---RITSGNPQNFFAINIKTGLITT 1207

Query: 308  DS-VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV--RE 364
             S  LDRE +  H L V   D    P+ +T ++ V V D ND+ P F +  Y+ ++  R+
Sbjct: 1208 TSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERD 1267

Query: 365  NLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEY 423
              + G  +    A DRD   NA + Y ++ G  D  F ++  +G+VS+R    +  A  Y
Sbjct: 1268 RKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSR---KQFTAGSY 1324

Query: 424  QLL-VEANDQGRNPGPLSATATVYIEVEDENDNYP---QFSEQNYVVQVPEDVGLNTAVL 479
             +L ++A D GR     S+TA ++IE   +    P    F E  Y   V E    +  V 
Sbjct: 1325 DILTIKAVDNGR--PQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVME----SDRVT 1378

Query: 480  RVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDG 539
             +      Q  N  + + I+ GN    F      G + +  PLD E    Y++S++  DG
Sbjct: 1379 EIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDG 1438

Query: 540  GRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENAR 599
                +      V ++VLD NDN P F    +  T+ E+V     ++ I+A D D  E  +
Sbjct: 1439 TNVAVTQ----VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD--EKHK 1492

Query: 600  LHYRL---VDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFG 656
            L Y +   +D+ S                    F+I  S+G +     LD E  + +   
Sbjct: 1493 LSYTVHSSIDSISM-----------------RKFRIDPSTGVLYTAERLDHEAQDKHILN 1535

Query: 657  VEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD- 715
            +   D   P   +   V + V D ND+ P FT P YE  + E AA+GS+VL + A D+D 
Sbjct: 1536 IMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDK 1595

Query: 716  -ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD---GTRSH 771
              N+ + Y +  GNT N F +      G+IT+    D     Q+VL++  +D      S 
Sbjct: 1596 GENAELIYTIEAGNTGNMFKIEPVL--GIITICKEPDMTTMGQFVLSIKVTDQGSPPMSA 1653

Query: 772  TAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDP 831
            TA V I+VT ++   P F    Y   V+E+  +GTS+  +SA  + T     + Y ++D 
Sbjct: 1654 TAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST-----LIYEVKDG 1708

Query: 832  VPQ--FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
                 F I+P SG + T   LDYE   +Y L I A    +   +   T+ I I+D NDNA
Sbjct: 1709 DINGIFTINPYSGVITTQKALDYERTSSYQLIIQA--TNMAGMASNATVNIQIVDENDNA 1766

Query: 890  PQFLWDFYQGSIFEDAPPST-------SILQVSATDRDSGPNGRLLYTFQGGDDGDGDFY 942
            P FL+  Y GS+ E AP ++       S L + ATD DS  N  L+Y           F 
Sbjct: 1767 PVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV-ESTAKKFFT 1825

Query: 943  IEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSAS-VEIQVTILDINDNAPMFEK 1001
            ++ ++G IRT   LD E +A ++      D GSP   + S VE+ + + D+NDN P+F +
Sbjct: 1826 VDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQ 1885

Query: 1002 DELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVE 1061
               E  +     VG  V K+ A DPD     ++ Y ++EG + HF  +D  +G L   ++
Sbjct: 1886 AVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFL-IDSNSGVL--TIK 1942

Query: 1062 LDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVT-NKSNSFP 1120
             +   +  Y+L+V+ +     S + V I++ +  D+   L   Q  ++  ++ N +N   
Sbjct: 1943 NNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSG--LHFTQSFYSTSISENNTNITK 2000

Query: 1121 TGVIGCIPAHDPDVSDSLNYTFVQ-GNELRL-----------LLLDPATGEL-----QLS 1163
              ++  +      +++ L Y+ +  GN+ ++           +  D    EL     + S
Sbjct: 2001 VAIVNAVGNR---LNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEAS 2057

Query: 1164 RDLDNNRPLEALMEVSVSD 1182
            R+LD+ R    ++ V++ D
Sbjct: 2058 RELDHLRVARVVVRVNIED 2076



 Score =  305 bits (780), Expect = 6e-82
 Identities = 283/979 (28%), Positives = 444/979 (45%), Gaps = 75/979 (7%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            KF   +YQ  + EN   GT ++ + A       +  + Y ++   D    G F I+  +G
Sbjct: 1670 KFIHKDYQAEVNENVDIGTSVILISAI-----SQSTLIYEVK---DGDINGIFTINPYSG 1721

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
             ++T   LD E   ++ L ++A + +    +AT  I ++  D ND++PVF  S+Y   + 
Sbjct: 1722 VITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIV--DENDNAPVFLFSQYSGSLS 1779

Query: 364  ENLEVGYEV-------LTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTRAVL 415
            E   +   V       L IRA+D DS  NA L Y+++   A   F ++ S+G + T A L
Sbjct: 1780 EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANL 1839

Query: 416  DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNY--VVQVPEDVG 473
            D E  A +   V   D G       +   V IEV D NDN P F++  +  ++ +P  VG
Sbjct: 1840 DHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVG 1899

Query: 474  LNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
            +   VL+V ATD D      + YS++ G++   F + S SG+L + N    +D   Y L 
Sbjct: 1900 VE--VLKVSATDPDSEVPPELTYSLMEGSL-DHFLIDSNSGVLTIKNNNLSKD--HYMLI 1954

Query: 534  IKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDAD 593
            +K  DG       S+ +V++ V +  D+   F  S +  ++ EN      V  + AV   
Sbjct: 1955 VKVSDG----KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAV--G 2008

Query: 594  SGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI-TVCAELDREEVEH 652
            +  N  L Y +++                   P   F+I ++SG I T     DREE E 
Sbjct: 2009 NRLNEPLKYSILN-------------------PGNKFKIKSTSGVIQTTGVPFDREEQEL 2049

Query: 653  YSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQAR 712
            Y   VEA         +   V + + D+NDN PVF    Y   +  DA  G+ +  + A 
Sbjct: 2050 YELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAI 2109

Query: 713  DRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRS 770
            D+D   N  +TY L   +    F ++   G  ++  A   D    +  V  +    G  S
Sbjct: 2110 DKDKGPNGEVTYVLQ--DDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPS 2167

Query: 771  HTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI-- 828
             +  V + +T  N   PVF    YT SV+ED  + T I +++A    + E   I Y+I  
Sbjct: 2168 LSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT---SPEGQGIIYIIID 2224

Query: 829  QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDN 888
             DP  QF ID D+G +  +  LDYE   AY LTI A D     +++  T+++L+ D NDN
Sbjct: 2225 GDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAE-VTVDLLVNDVNDN 2283

Query: 889  APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTF-QGGDDGDGDFYIEPTS 947
             P F    Y  ++ E +   T +LQV + D DS  N  + Y   Q   +    F+I+ +S
Sbjct: 2284 PPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSS 2343

Query: 948  GVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELF 1007
            G+I T R LD E V    L   ++D G P+ LS+ V + + I D+NDN P+F +   E +
Sbjct: 2344 GLILTARMLDHELVQHCTLKVRSIDSGFPS-LSSEVLVHIYISDVNDNPPVFNQLIYESY 2402

Query: 1008 VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVR 1067
            V E  P G  V  ++A+D D     ++ Y I+ G+ R  F +D  +G +         + 
Sbjct: 2403 VSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRME 2462

Query: 1068 REYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG--VIG 1125
              Y L V  +     S A VHI ++  N   P         + YV     +   G  VI 
Sbjct: 2463 PLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQ-----STYVAEVRENVAAGTKVIH 2517

Query: 1126 CIPAH-DPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVS--D 1182
                  DP     ++Y  +        L+D + G++  +  LD   PLE  + + V   D
Sbjct: 2518 VRATDGDPGTYGQISYAIINDFAKDRFLID-SNGQVITTERLDRENPLEGDVSIFVRALD 2576

Query: 1183 GIHSVTAFCTLRVTIITDD 1201
            G    T FCT+RV ++ ++
Sbjct: 2577 G-GGRTTFCTVRVIVVDEN 2594



 Score =  298 bits (764), Expect = 4e-80
 Identities = 292/1088 (26%), Positives = 473/1088 (43%), Gaps = 141/1088 (12%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F    Y V + E+ P  T + Q+ A     G      YY +   D      F +   +G 
Sbjct: 158  FSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD-----LFSVHPTSGV 212

Query: 305  VSTDSVLDRETKETHVLRVKAVD-----YSTPPRSATTYITVLVKDTNDHSPVFEQSEYR 359
            +S    L+ + K  + L + AVD     Y     S+T  + V ++  N+H+P      + 
Sbjct: 213  ISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHV 272

Query: 360  ERVRENLEVGYEVLTIRASDRDSPINANLRYR--VLGGAWDVFQLNESSGVVSTRAVLDR 417
                E  E  Y V+T+   D D   N  +     V G   D F L +    ++   + +R
Sbjct: 273  PFSLEK-EPTYAVVTV--DDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKER 329

Query: 418  EEAA------EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPE- 470
            ++         Y L ++A D+G +P   SA   VYI     +    +F ++ Y V + E 
Sbjct: 330  KQIDWESFPYGYNLTLQAKDKG-SPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEF 388

Query: 471  -DVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQK 529
               G+  A++++     D      + Y +  G  A  F ++  SG++    PL+    + 
Sbjct: 389  SPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEV 442

Query: 530  YSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQA 589
            Y L +  ++G      +    V++ + D ND+ P F    + A V E+VP+G  V+ + A
Sbjct: 443  YKLEVTNKEG------DLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSA 496

Query: 590  VDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREE 649
             D D GEN  + Y +   AS  L                PF I+  +G I+   ELD E 
Sbjct: 497  SDKDKGENGYITYSI---ASLNL---------------LPFVINQFTGVISTTEELDFES 538

Query: 650  V-EHYSFGVEAVDHGSPPM-SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL 707
              E Y F V A D GSP    S  +V+I + +VNDN P+F +   +  ++ D  VG  + 
Sbjct: 539  SPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHIT 598

Query: 708  TLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG 767
             + A D D   ++ Y++  GN    F L+   G   +  +L     +   + L +TA+DG
Sbjct: 599  AVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDG 658

Query: 768  TR--------------------------------------SHTAHVLINVTDA------- 782
                                                       A+  +N+ D        
Sbjct: 659  ENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSI 718

Query: 783  NTHRPVFQSSHYT-VSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDP 839
            N   P F  S  + V+V ED PVG +I  + A D D+G N ++ + I D      F ID 
Sbjct: 719  NRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDM 778

Query: 840  DSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQG 899
            ++G +  +M +D E+   Y L I   D G PQKS    L I + DANDN+P F+ D Y  
Sbjct: 779  ETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSV 838

Query: 900  SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRE 959
            +I E +   T I+QV A D+D G NG + Y+          F I  ++G++    +LDRE
Sbjct: 839  NILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQ---QFAINSSTGIVYVADQLDRE 895

Query: 960  NVAVYNLWALAVDRG-SPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVV 1018
            + A Y+L   A D+  S   L + V ++V + D+ND +P F      + V E+ PVG+V+
Sbjct: 896  SKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI 955

Query: 1019 AKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA-- 1076
            A +  +DPD G   Q+ Y +V  D    F++D  +G +R   ELD+E ++ Y L V+A  
Sbjct: 956  AWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD 1014

Query: 1077 ----TSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDP 1132
                 S   VS   V ++ V++N + P  PDF ++ +     +++   T V+  + A D 
Sbjct: 1015 KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGS---VKENSRIGTSVLQ-VTARDE 1070

Query: 1133 DV--SDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTA 1189
            D      + Y+   G+ L    +D  +G +  +  LD        + V  +D G+  V  
Sbjct: 1071 DSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGV--VPL 1128

Query: 1190 FCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQ- 1248
            + T+ V I  +D+  N+       ++ E    P+          V+  +  DV V  +Q 
Sbjct: 1129 YSTIEVYIEVEDVNDNA------PLTSEPIYYPV----------VMENSPKDVSVIQIQA 1172

Query: 1249 NDTDVSSN 1256
             D D SSN
Sbjct: 1173 EDPDSSSN 1180



 Score =  281 bits (720), Expect = 5e-75
 Identities = 200/626 (31%), Positives = 310/626 (49%), Gaps = 44/626 (7%)

Query: 250  YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDS 309
            Y   L E+ P+  +IL++ A     G    + Y + G         F +D  +G + T +
Sbjct: 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYG----SGNSEFFLDPESGELKTLA 3089

Query: 310  VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVG 369
            +LDRE    + L  KA D     R   + I ++++D ND+ PVF    Y   V EN    
Sbjct: 3090 LLDRERIPVYSLMAKATDGGG--RFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATK 3147

Query: 370  YEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEA 429
              +  ++A D D  IN  + Y +   A  VF ++ SSG++     LDRE+ + Y + V A
Sbjct: 3148 ALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRA 3207

Query: 430  NDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
             DQ  +PG  LS+  TV I V D NDN P F  ++Y+V VPED    T VL V AT +D 
Sbjct: 3208 TDQ--SPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDI 3265

Query: 489  GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
            G NA I Y I SGN  G+F ++  +G + V   LD+E  +++ L ++A+DGG P L ++ 
Sbjct: 3266 GTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPAL-SAV 3324

Query: 549  GVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTA 608
              V++ + DVNDN P F    + A + E+  +G  V+ + A D DS  N ++H+ +V+  
Sbjct: 3325 ATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVN-- 3382

Query: 609  STFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMS 668
                     G +      D  F +    G + V  +LDRE V  YS  V+AVD G P MS
Sbjct: 3383 ---------GDR------DNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMS 3427

Query: 669  SSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA---NSVITYQLT 725
            S+ +V+I + DVNDN PVFT   Y   + E+  VG+S+L L   DRD+       ++ + 
Sbjct: 3428 STATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSIL 3487

Query: 726  GGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR----SHTAHVLINVTD 781
             GN    F L      G++  A+   + +  +YVL V A D  +    SHT ++ + V +
Sbjct: 3488 SGNEEEEFVLDPH---GILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHT-YIRVRVIE 3543

Query: 782  ANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ-DPVPQFRIDPD 840
             +TH+P        +   ED   G  I  + A D+D  +   +T+ ++ +    F+++  
Sbjct: 3544 ESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYD--VLTFALKSEQKSLFKVNSH 3601

Query: 841  SGTMYTMMELDYENQVAYTLTIMAQD 866
             G +  +  LD      Y L +   D
Sbjct: 3602 DGKIIALGGLD---SGKYVLNVSVSD 3624



 Score =  236 bits (602), Expect = 3e-61
 Identities = 263/1024 (25%), Positives = 434/1024 (42%), Gaps = 146/1024 (14%)

Query: 235  RGTSGRGSLKFPMPN--YQVALFENEPAGTLI------------LQLHAHYTI-EGEEER 279
            +G  G G L F   +  Y   ++EN  A T +            L     Y I  G+EE 
Sbjct: 31   QGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEG 90

Query: 280  VSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYI 339
                 E +  +    + RI +  G     ++L+RE ++ ++L VK          A T +
Sbjct: 91   FFKAEEVIIADFC--FLRIRTKGG---NSAILNREIQDNYLLIVKG-SVRGEDLEAWTKV 144

Query: 340  TVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV 399
             + V D ND  P+F  + Y   + E+  +   V  + A+D D   N    Y       D+
Sbjct: 145  NIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEF-YYYFKNKVDL 203

Query: 400  FQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGR----NPGPLSATATVYIEVEDENDN 455
            F ++ +SGV+S    L+ +E   Y L + A D+G     N G +S+TA +Y+ +E  N++
Sbjct: 204  FSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNG-VSSTAKLYVHIERINEH 262

Query: 456  YPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIH-YSILSGNVAGQFYLHSLSG 514
             P     + V  VP  +        V   D D G N  I   SI++G+   QF+L     
Sbjct: 263  APTI---HVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGK 319

Query: 515  ILDVI-----NPLDFEDV-QKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI-FVS 567
             L+         +D+E     Y+L+++A+D G P   ++   V +      D  PI F  
Sbjct: 320  WLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIG-NPTRDTVPIRFEK 378

Query: 568  SPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPD 627
              +  ++ E  P G  V  ++     S E   + Y+L                  +P  D
Sbjct: 379  EVYDVSISEFSPPGVVVAIVKL----SPEPIDVEYKL------------------SPGED 416

Query: 628  -FPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPV 686
               F+I+  SG I     L+  + E Y   V      +        V+I++ D ND+ P 
Sbjct: 417  AVYFKINPRSGLIVTARPLNTVKKEVYKLEVT-----NKEGDLKAQVTISIEDANDHTPE 471

Query: 687  FTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLI 744
            F QP Y+  +NE   VG+SVLT+ A D+D   N  ITY +    + N       +  G+I
Sbjct: 472  FQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIA---SLNLLPFVINQFTGVI 528

Query: 745  TLALPLDYKQEQQ-YVLAVTASDGTRSHTAHVLINVT----DANTHRPVFQSSHYTVSVS 799
            +    LD++   + Y   V ASD    +     +NVT    + N + P+F+       +S
Sbjct: 529  STTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVIS 588

Query: 800  EDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYE--NQVA 857
             D PVG  I  +SA D D  E  +   +  + +  F ++PDSG +     L         
Sbjct: 589  YDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGN 648

Query: 858  YTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF------------------------- 892
            + L I A D      +D  ++ I +L    ++  F                         
Sbjct: 649  FALRITATDG--ENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKL 706

Query: 893  -----LWDFY----QGSIF-----------EDAPPSTSILQVSATDRDSGPNGRLLYTFQ 932
                   DFY    QG  F           ED P   +IL++ A D DSG NG++L+T  
Sbjct: 707  NLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTIS 766

Query: 933  GGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDI 992
             G+  D  F I+  +G ++    +DRE+  +Y L     D G+P   S  + + + + D 
Sbjct: 767  DGNT-DSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRL-LTINVEDA 824

Query: 993  NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLL 1052
            NDN+P+F +D   + + E++ +G+ + ++ A D D G N ++ Y ++    +  F ++  
Sbjct: 825  NDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINSS 882

Query: 1053 NGDLRAMVELDFEVRREYVLVVQA-----TSAPLVSRATVHILLVDQND-NPPVLPDFQI 1106
             G +    +LD E +  Y L ++A     +   L S  T+ + L D ND +P  +P    
Sbjct: 883  TGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIP---- 938

Query: 1107 LFNNYVTNKSNSFPTG-VIGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLS 1163
              ++Y        P G VI  +  HDPD  +   + Y+ V     R   +D A+G ++LS
Sbjct: 939  --SSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR-FEIDKASGAIRLS 995

Query: 1164 RDLD 1167
            ++LD
Sbjct: 996  KELD 999



 Score =  234 bits (597), Expect = 1e-60
 Identities = 239/934 (25%), Positives = 406/934 (43%), Gaps = 133/934 (14%)

Query: 349  HSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGV 408
            ++ V+E S  R  V     +G  ++ +         + +++YR++ G  + F   E   +
Sbjct: 49   NATVYENSAARTYVNSQSRMGITLIDL---------SWDIKYRIVSGDEEGFFKAEEVII 99

Query: 409  VS-----------TRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYP 457
                           A+L+RE    Y L+V+ + +G +   L A   V I+V D ND  P
Sbjct: 100  ADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED---LEAWTKVNIQVLDMNDLRP 156

Query: 458  QFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILD 517
             FS   Y V + E   L T+V +V ATD D G N   +Y     N    F +H  SG++ 
Sbjct: 157  LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF--KNKVDLFSVHPTSGVIS 214

Query: 518  VINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVS-----VQVLDVNDNEP---IFVSSP 569
            +   L++++  +Y L I A D G   L  ++GV S     V +  +N++ P   +    P
Sbjct: 215  LSGRLNYDEKNRYDLEILAVDRGM-KLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273

Query: 570  FQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFP 629
            F    LE  P  Y VV +   D D G N       +++ S   G            P   
Sbjct: 274  FS---LEKEPT-YAVVTVD--DLDDGANGE-----IESVSIVAG-----------DPLDQ 311

Query: 630  FQIHNSSGWITVCAELDREEVE------HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDN 683
            F +     W+      +R++++       Y+  ++A D GSP   S+           D 
Sbjct: 312  FFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDT 371

Query: 684  DPV-FTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGG 742
             P+ F +  Y++ ++E +  G  V  ++      +  + Y+L+ G     F ++ +   G
Sbjct: 372  VPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID--VEYKLSPGEDAVYFKINPR--SG 427

Query: 743  LITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDR 802
            LI  A PL+  +++ Y L VT  +G     A V I++ DAN H P FQ   Y   V+E  
Sbjct: 428  LIVTARPLNTVKKEVYKLEVTNKEGDLK--AQVTISIEDANDHTPEFQQPLYDAYVNESV 485

Query: 803  PVGTSIATLSANDEDTGENARITYVIQD-PVPQFRIDPDSGTMYTMMELDYENQ-VAYTL 860
            PVGTS+ T+SA+D+D GEN  ITY I    +  F I+  +G + T  ELD+E+    Y  
Sbjct: 486  PVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRF 545

Query: 861  TIMAQDNGIPQKSDT-TTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDR 919
             + A D G P + ++   + I I + NDN+P F     QG I  D P    I  VSA D 
Sbjct: 546  IVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDI 605

Query: 920  DSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPL 979
            D      + Y    G++  G FY+ P SGV++ ++ L    +   N +AL +       L
Sbjct: 606  DE--LELVKYKIISGNE-LGFFYLNPDSGVLQLKKSLTNSGIKNGN-FALRITATDGENL 661

Query: 980  SASVEIQVTIL--------------------------------------------DINDN 995
            +  + I +++L                                             IN  
Sbjct: 662  ADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQ 721

Query: 996  APMFEKD-ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNG 1054
             P F+K    ++ V+E+ PVG+ + KI+A D D G N ++++ I +G+    F +D+  G
Sbjct: 722  GPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETG 781

Query: 1055 DLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLV---DQNDNPPVLPDFQILFNNY 1111
             L+ ++ +D E    Y+L +         +++  +L +   D NDN PV      + ++Y
Sbjct: 782  QLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPV-----FIQDSY 836

Query: 1112 VTN--KSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNN 1169
              N  +S+   T +I  + A D D+  +   T+    + +   ++ +TG + ++  LD  
Sbjct: 837  SVNILESSGIGTEIIQ-VEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRE 895

Query: 1170 RPLEALMEVSVSDGIHS-VTAFCTLRVTIITDDM 1202
                  +++   D   S    F  + + +  DD+
Sbjct: 896  SKANYSLKIEARDKAESGQQLFSVVTLKVFLDDV 929



 Score =  161 bits (408), Expect = 8e-39
 Identities = 163/602 (27%), Positives = 276/602 (45%), Gaps = 52/602 (8%)

Query: 643  AELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAV 702
            A L+RE  ++Y   V+    G   + + T V+I VLD+ND  P+F+  TY + + E   +
Sbjct: 115  AILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL 173

Query: 703  GSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAV 762
             +SV  + A D D  S   +     N  + F++      G+I+L+  L+Y ++ +Y L +
Sbjct: 174  RTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYDEKNRYDLEI 231

Query: 763  TASD-GTR-------SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSAN 814
             A D G +       S TA + +++   N H P      +     E  P    +     +
Sbjct: 232  LAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLD 291

Query: 815  DEDTGENARITYVIQDPVPQFRIDPDSGTM--YTMME---LDYEN-QVAYTLTIMAQDNG 868
            D   GE   ++ V  DP+ QF +  +   +  Y + E   +D+E+    Y LT+ A+D G
Sbjct: 292  DGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKG 351

Query: 869  IPQKSDTTTLEILILDANDNAP-QFLWDFYQGSIFEDAPPST--SILQVSATDRDSGPNG 925
             PQK        +     D  P +F  + Y  SI E +PP    +I+++S    D     
Sbjct: 352  SPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID----- 406

Query: 926  RLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEI 985
             + Y    G+D    F I P SG+I T R L+     VY L          T     ++ 
Sbjct: 407  -VEYKLSPGEDAVY-FKINPRSGLIVTARPLNTVKKEVYKL--------EVTNKEGDLKA 456

Query: 986  QVTIL--DINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDM 1043
            QVTI   D ND+ P F++   + +V E+ PVG+ V  + A+D D+G N  I Y I   ++
Sbjct: 457  QVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNL 516

Query: 1044 RHFFQLDLLNGDLRAMVELDFEVRRE-YVLVVQATS--APL--VSRATVHILLVDQNDNP 1098
              F  ++   G +    ELDFE   E Y  +V+A+   +P    S   V I + + NDN 
Sbjct: 517  LPFV-INQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNS 575

Query: 1099 PVLPDFQILFNNYVTNKSNSFPTGV-IGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPAT 1157
            P+    ++     +   S  FP G  I  + A D D  + + Y  + GNEL    L+P +
Sbjct: 576  PLFE--KVACQGVI---SYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDS 630

Query: 1158 GELQLSRDLDNN--RPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMS 1215
            G LQL + L N+  +     + ++ +DG  ++    ++ ++++   + + S + R   ++
Sbjct: 631  GVLQLKKSLTNSGIKNGNFALRITATDG-ENLADPMSINISVLHGKVSSKSFSCRETRVA 689

Query: 1216 QE 1217
            Q+
Sbjct: 690  QK 691



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 45/134 (33%), Positives = 56/134 (41%), Gaps = 25/134 (18%)

Query: 1307 CLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDL 1366
            C R PC++   C  +                     P  G +C C   FTG  CE+EI  
Sbjct: 4025 CKRSPCQHGGSCTGL---------------------PSGGYQCTCLSQFTGRNCESEITA 4063

Query: 1367 CYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGF 1426
            C+ +PC   G C      + C C    TG  CE D     C    C+NGG+CVN + G F
Sbjct: 4064 CFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEEDI--NECEREECENGGSCVN-VFGSF 4120

Query: 1427 HCVCPPGEYERPYC 1440
             C C PG Y   YC
Sbjct: 4121 LCNCTPG-YVGQYC 4133



 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 81/328 (24%), Positives = 136/328 (41%), Gaps = 42/328 (12%)

Query: 1646 CAARRNFCDGRRCQNGGTCVN---RWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSW 1702
            C    + C  + C     CV+       +LC+CP    GK  E +      F+G S + +
Sbjct: 3792 CPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCP---PGKLGECSGHTSLSFAGNSYIKY 3848

Query: 1703 SDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESV 1762
                      + L L  RT + + ++M  T   P    L+I++  L F++  G S    +
Sbjct: 3849 RLSENSKEEDFKLALRLRTLQSNGIIMY-TRANPCII-LKIVDGKLWFQLDCG-SGPGIL 3905

Query: 1763 MLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYG-MDQNKADI--------GGML 1813
             +SG  V DG WH + +EL         ++  +++LD   +++ +A +          + 
Sbjct: 3906 GISGRAVNDGSWHSVFLELN--------RNFTSLSLDDSYVERRRAPLYFQTLSTESSIY 3957

Query: 1814 PGLTVRSVVVGGASEDKVS-VRRGFRGCMQGVRMGGTPTNVATLNMNNALKV---RVKDG 1869
             G  V++  +   ++ +V+ V  GF+GC+  V +      +     + A  V    +K G
Sbjct: 3958 FGALVQADNIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLG 4017

Query: 1870 CDV-DDPCTSSPCPPNSRCHDAWE-DYSCVCDKGYLGINC---VDACHLNPCENMGACVR 1924
            C +  D C  SPC     C       Y C C   + G NC   + AC  NPC N G+C  
Sbjct: 4018 CVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSC-- 4075

Query: 1925 SPGSPQG--YVCECGPSHYGPYCENKLD 1950
                P G  ++C C     G  CE  ++
Sbjct: 4076 ---DPIGNTFICNCKAGLTGVTCEEDIN 4100



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 32/113 (28%), Positives = 53/113 (46%), Gaps = 9/113 (7%)

Query: 1616 QFVGCMRNLSVDGKNVDMAG--FIAN---NGTREGCAARRNFCDGRRCQNGGTCVNRWNM 1670
            +   C  N   +G + D  G  FI N     T   C    N C+   C+NGG+CVN +  
Sbjct: 4060 EITACFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGS 4119

Query: 1671 YLCECPLRFGGKNCE-QAMPHPQLFSGESVVSWSDL---NIIISVPWYLGLMF 1719
            +LC C   + G+ C  + +  P + +G S V   +L    +++ V + L ++F
Sbjct: 4120 FLCNCTPGYVGQYCGLRPVVVPNIQAGHSYVGKEELIGIAVVLFVIFILVVLF 4172



 Score = 32.7 bits (73), Expect = 5.6
 Identities = 18/58 (31%), Positives = 20/58 (34%), Gaps = 22/58 (37%)

Query: 1303 DDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYC 1360
            D N C RE CEN   CV+V                           C C PG+ G YC
Sbjct: 4098 DINECEREECENGGSCVNV----------------------FGSFLCNCTPGYVGQYC 4133


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score =  453 bits (1165), Expect = e-126
 Identities = 418/1508 (27%), Positives = 658/1508 (43%), Gaps = 191/1508 (12%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYM-EGLFDERSRGY-FRIDSA 301
            KF  P Y   + E+ P GT I  + A ++       V Y + +G   E +R   F ID  
Sbjct: 2702 KFSEPFYTFTVSEDVPIGTEIDLIRAEHS-----GTVLYSLVKGNTPESNRDESFVIDRQ 2756

Query: 302  TGAVSTDSVLDRETKETHVLRVKA-VDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE 360
            +G +  +  LD ET + +   + A          A+  +++ VKD ND+SPVFE S Y  
Sbjct: 2757 SGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEA 2816

Query: 361  RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG----AWDVFQLNESSGVVSTRAVLD 416
             + ENL  G  V+ IRASD DS  N  + Y +         + F +N  +G ++T   LD
Sbjct: 2817 FIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELD 2876

Query: 417  REEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNT 476
             E+   YQ+ V A+D G     LS+TA V + V D ND+ P+F+ + Y   V ED     
Sbjct: 2877 HEKRDNYQIKVVASDHGEKI-QLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGG 2935

Query: 477  AVLRVQATDRDQGQ-NAAIHYSILSGNVAGQFYLHSLSGILDVI--NPLDFEDVQKYSLS 533
             +  +  TD D  + N  + Y I  G+  GQF + ++     V    PLD E    Y L+
Sbjct: 2936 VIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLT 2995

Query: 534  IKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDAD 593
            I A DG      +S  +V V+VLD NDN P+   + +  T+ E+V  G  ++ I A DAD
Sbjct: 2996 ITATDG----TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDAD 3051

Query: 594  SGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHY 653
               NA + Y       T LG G+             F+++  +G +     LDREE   Y
Sbjct: 3052 IRSNAEITY-------TLLGSGAE-----------KFKLNPDTGELKTSTPLDREEQAVY 3093

Query: 654  SFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARD 713
               V A D G        S+ +T+ DVNDN P F+   Y + + E+   G+ +  +QA D
Sbjct: 3094 HLLVRATDGGG--RFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATD 3151

Query: 714  RDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---- 767
             DA  N  I Y L   +   +F+++     G+I L  PLD + +  Y L++ A D     
Sbjct: 3152 ADAGLNRKILYSLID-SADGQFSINEL--SGIIQLEKPLDRELQAVYTLSLKAVDQGLPR 3208

Query: 768  TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYV 827
              + T  V+++V D N + PVF+   Y  +VSED  VGT +  + A   D   NA ITY 
Sbjct: 3209 RLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYS 3268

Query: 828  I--QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDA 885
            I   +   +F ID  +G ++ +  LDYE+   Y LT+ A D G P  SD  T+ + + D 
Sbjct: 3269 IISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDI 3328

Query: 886  NDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEP 945
            NDN P F  D Y   I EDA    S++ V A D D   N  + Y+   G+ G   F I+P
Sbjct: 3329 NDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSS-FTIDP 3387

Query: 946  TSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELE 1005
              G ++  + LDRE ++ Y L   A D GSP P   +  + + + D+NDNAP+F +    
Sbjct: 3388 VRGEVKVTKLLDRETISGYTLTVQASDNGSP-PRVNTTTVNIDVSDVNDNAPVFSRGNYS 3446

Query: 1006 LFVEENNPVGSVVAKIRANDPDEGPNAQ-IMYQIVEGDMRHFFQLDLLNGDLRAMVELDF 1064
            + ++EN PVG  V ++   D D   N     + IV G+    F+++   G L     +  
Sbjct: 3447 VIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIKR 3505

Query: 1065 EVRREYVLVVQATS--APLVSRAT-VHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT 1121
            + +  Y+L V+      P +S  T + I +++++  PP +   +I    ++T+    +  
Sbjct: 3506 KEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEI----FITSSGEEYSG 3561

Query: 1122 GVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVS 1181
            GVIG I A D DV D+L Y+     +  L  +    G+L   + LD     + L+ VSV+
Sbjct: 3562 GVIGKIHATDQDVYDTLTYSLDPQMD-NLFSVSSTGGKLIAHKKLDIG---QYLLNVSVT 3617

Query: 1182 DGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDD 1241
            DG  +  A  T+ +  +T +ML ++I +R  N++ E+F+      F   +  +L   ++D
Sbjct: 3618 DGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRALRNILGVRRND 3677

Query: 1242 VFVFNVQNDTDVSSNILNVTFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLP 1301
            + + ++Q+        L+V      PG  +     ++ L  +I  + T +  I   R+L 
Sbjct: 3678 IQIVSLQSSEPHPH--LDVLLFVEKPGSAQ---ISTKQLLHKINSSVTDIEEIIGVRILN 3732

Query: 1302 FDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVL--FRPIHPINGL----RCRCPPGF 1355
                +C    C  +  C   +  D S     ST  L    P H    +      RCPP  
Sbjct: 3733 VFQKLCAGLDCP-WKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCKEGRCPPVH 3791

Query: 1356 TGDYCETEIDLCYSDPCGANGRCRSR--EGGYTCECFEDFTGEHCEVDARSGRCANGVCK 1413
             G         C  DPC     C S   E  +TC C             R G+C      
Sbjct: 3792 HG---------CEDDPCPEGSECVSDPWEEKHTCVC----------PSGRFGQC------ 3826

Query: 1414 NGGTCVNLLIGGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFR--GLRQRFHFTISLTFA 1471
                              PG         ++ +    S+V +R      +    +++   
Sbjct: 3827 ------------------PGS--------SSMTLTGNSYVKYRLTENENKLEMKLTMRLR 3860

Query: 1472 TQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQ 1531
            T   + +++Y        D+  LEI   ++Q  F  G     V+ +    V+DG+WH+V 
Sbjct: 3861 TYSTHAVVMY----ARGTDYSILEIHHGRLQYKFDCGSGPGIVSVQ-SIQVNDGQWHAVA 3915

Query: 1532 VQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKS 1591
            ++                     A + +D   T                A GT  G+ K+
Sbjct: 3916 LEV----------------NGNYARLVLDQVHT----------------ASGTAPGTLKT 3943

Query: 1592 LDLTGPLLLGGVPNLPEDFPVHNRQ------FVGCMRNLSVDGKNVDM-------AGFIA 1638
            L+L   +  GG  ++ +    H R       F GCM ++ ++G+ + +       A    
Sbjct: 3944 LNLDNYVFFGG--HIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEE 4001

Query: 1639 NNGTREGC-AARRNFCDGRRCQNGGTC-VNRWNMYLCECPLRFGGKNCEQAM----PHPQ 1692
            +     GC       C    CQNGG C  +    Y C+C   + G +CE ++      P 
Sbjct: 4002 SVDVSPGCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPC 4061

Query: 1693 LFSGESVV 1700
            L+ G  VV
Sbjct: 4062 LYGGTCVV 4069



 Score =  449 bits (1156), Expect = e-125
 Identities = 314/956 (32%), Positives = 484/956 (50%), Gaps = 51/956 (5%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F    Y+V L EN P  TL++++       G    V+Y++   F  + R Y    +  G 
Sbjct: 2492 FLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDF-AKDRFYI---NERGQ 2547

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
            + T   LDRET    V+ V+ +      + A   + V++ D ND++P F  ++Y   +  
Sbjct: 2548 IFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGS 2607

Query: 365  NLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV---FQLNESSGVVSTRAVLDREEAA 421
            +   G  V+ + ASD D   NA++ Y +   +  V    ++N+ SGV++T+  L   E  
Sbjct: 2608 SAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENE 2667

Query: 422  EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRV 481
             +   V A D G +P   S    VY+++       P+FSE  Y   V EDV + T +  +
Sbjct: 2668 FFTFFVRAVDNG-SPSKESVVL-VYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLI 2725

Query: 482  QATDRDQGQNAAIHYSILSGNVAGQ-----FYLHSLSGILDVINPLDFEDVQKYSLSIKA 536
            +A       +  + YS++ GN         F +   SG L +   LD E  + Y  SI A
Sbjct: 2726 RAE-----HSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILA 2780

Query: 537  QDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE 596
            +       + +S  VS+QV D NDN P+F SSP++A ++EN+P G  V+ I+A DADSG 
Sbjct: 2781 RCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGT 2840

Query: 597  NARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFG 656
            N ++ Y L  + S  +                 F I+  +GWIT   ELD E+ ++Y   
Sbjct: 2841 NGQVMYSLDQSQSVEVIES--------------FAINMETGWITTLKELDHEKRDNYQIK 2886

Query: 657  VEAVDHGSPPMSSSTS-VSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
            V A DHG     SST+ V +TV DVND+ P FT   Y+  ++ED   G  +  L   D D
Sbjct: 2887 VVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDAD 2946

Query: 716  ANSV---ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHT 772
            +  +   +TY +TGG+   +FA+ + +    + +  PLD ++   Y+L +TA+DGT S  
Sbjct: 2947 SEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSK 3006

Query: 773  AHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDP 831
            A V + V DAN + PV + + Y+ ++ ED   G  I  +SA D D   NA ITY ++   
Sbjct: 3007 AIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSG 3066

Query: 832  VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNG--IPQKSDTTTLEILILDANDNA 889
              +F+++PD+G + T   LD E Q  Y L + A D G    Q S   TLE    D NDNA
Sbjct: 3067 AEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLE----DVNDNA 3122

Query: 890  PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
            P+F  D Y  ++FE+  P T + +V ATD D+G N ++LY+    D  DG F I   SG+
Sbjct: 3123 PEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLI--DSADGQFSINELSGI 3180

Query: 950  IRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVE 1009
            I+ ++ LDRE  AVY L   AVD+G P  L+A+  + V++LDINDN P+FE  E    V 
Sbjct: 3181 IQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVS 3240

Query: 1010 ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE 1069
            E+  VG+ V ++ A   D   NA+I Y I+ G+    F +D   G +  +  LD+E   E
Sbjct: 3241 EDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHE 3300

Query: 1070 YVLVVQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGC 1126
            Y L V+AT   +  L   ATV++ + D NDN PV    Q  +   ++  +    + +   
Sbjct: 3301 YYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFS--QDTYTTVISEDAVLEQSVITVM 3358

Query: 1127 IPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
                D   +  ++Y+ + GN+     +DP  GE+++++ LD        + V  SD
Sbjct: 3359 ADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414



 Score =  421 bits (1082), Expect = e-117
 Identities = 328/1059 (30%), Positives = 512/1059 (48%), Gaps = 87/1059 (8%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F  PNY+V + E+ P GT+I+ L AH    G+  +V Y +     +   G F +D  +GA
Sbjct: 927  FIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLL----DHGEGNFDVDKLSGA 982

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPR-SATTYITVLVKDTND--HSPVFEQSEYRER 361
            V     LD E K+ + L V+A D   P   S+T Y+ V V D N+  H PVF     +  
Sbjct: 983  VRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042

Query: 362  VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAW-DVFQLNESSGVVSTRAVLDREEA 420
            V+E+  VG  V+T+ A D D+  +  +RY +  G+   VF++ E +GV+ T   LDRE  
Sbjct: 1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDREST 1102

Query: 421  AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480
            + Y L V A DQG    PLS+   +YIEVED NDN PQ SE  Y  ++ E+   + +V++
Sbjct: 1103 SHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQ 1160

Query: 481  VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN-PLDFEDVQKYSLSIKAQDG 539
            ++A D D   N  + Y I SGN  G F +H  +G++   +  LD E   ++ L +   D 
Sbjct: 1161 IEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN 1220

Query: 540  GRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGY-------PVVHIQAVDA 592
            G PP    + V+ V++LD NDN+P F+   ++  + E             P+ H+ A D 
Sbjct: 1221 GSPPKSTIARVI-VKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279

Query: 593  DSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEH 652
            D G NA + Y + D       G   G           F I   +G   V ++      E+
Sbjct: 1280 DEGPNAEISYSIED-------GNEHGK----------FFIEPKTG--VVSSKRFSAAGEY 1320

Query: 653  YSFGVEAVDHGSPPMSSSTSVSITVLDVNDN--DPV-FTQPTYELRLNEDAAVGSSVLTL 709
                ++AVD+G P  SS+T + I  +       +P+ F +  +   + E   V   +  +
Sbjct: 1321 DILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVI 1380

Query: 710  QARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR 769
                      + + +TGGN  + F +   +G G I +A PLD +Q+  Y L V A+DGT 
Sbjct: 1381 SVEP--PGIPLWFDITGGNYDSHFDVD--KGTGTIIVAKPLDAEQKSNYNLTVEATDGTT 1436

Query: 770  SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
            +    V I V D N HRP F +S Y V + ED    T I  +SA D+D  E  ++ Y +Q
Sbjct: 1437 TILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD--EKNKLIYTLQ 1494

Query: 830  ---DPVP--QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILD 884
               DP+   +FR+DP +G++YT  +LD+E    +TLT+M +D  +P K +   + + + D
Sbjct: 1495 SSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554

Query: 885  ANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIE 944
             ND+AP F    Y+G ++E A   + +LQV+A D+D G N  +LY+ + G+ G+  F I+
Sbjct: 1555 TNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGN-SFMID 1613

Query: 945  PTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDEL 1004
            P  G I+T + LDR N A Y+L   A D+GSP P+S    +++ +   ++ +P F   E 
Sbjct: 1614 PVLGSIKTAKELDRSNQAEYDLMVKATDKGSP-PMSEITSVRIFVTIADNASPKFTSKEY 1672

Query: 1005 ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDF 1064
             + + E   +GS V  + A+       + ++Y+I +G+    F ++  +G +     LDF
Sbjct: 1673 SVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDF 1727

Query: 1065 EVRREYVLVVQATS-APLVSRATVHILLVDQNDNPPVL--PDFQILFN-----NYVTNKS 1116
            E    Y L++Q T+ A L +  TV + L D+NDN PV    ++  L +     N V    
Sbjct: 1728 ETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTD 1787

Query: 1117 NSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALM 1176
             + P  VI    A D D +  L Y  V+ +      +D +TG +     LD         
Sbjct: 1788 RNVPL-VIRAADA-DKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHF 1845

Query: 1177 EVSVSD-GIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVL 1235
             V V D G   + A     VT+   D+          N     F  PL        A++L
Sbjct: 1846 TVQVHDMGTPRLFAEYAANVTVHVIDI----------NDCPPVFAKPLYE------ASLL 1889

Query: 1236 STTKDDVFVFNVQNDTDVSSNILNVTFSALLPGGVRGQF 1274
              T   V V  V N TD  S+  +    ++  G +  +F
Sbjct: 1890 LPTYKGVKVITV-NATDADSSAFSQLIYSITEGNIGEKF 1927



 Score =  366 bits (939), Expect = e-100
 Identities = 297/1038 (28%), Positives = 496/1038 (47%), Gaps = 73/1038 (7%)

Query: 256  ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315
            EN+P G+ ++ +++     G   ++ Y + G  ++     F ID  TG +   S LDRET
Sbjct: 728  ENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSC---FMIDMETGMLKILSPLDRET 784

Query: 316  KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTI 375
             + + L +   D   P ++A   + V+V D ND+ P F Q  Y   V E+ EV  E++ +
Sbjct: 785  TDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQV 844

Query: 376  RASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRN 435
             A+D+D   N ++ Y ++    D F ++  +GVV+    LDRE   E+ L +EA DQ R 
Sbjct: 845  EATDKDLGPNGHVTYSIVTDT-DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQARE 903

Query: 436  PGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIH 495
               L +T  V + +ED NDN P F   NY V+V ED+   T ++ ++A D D GQ+  + 
Sbjct: 904  EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVR 963

Query: 496  YSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQV 555
            YS+L  +  G F +  LSG + ++  LDFE  Q Y+L+++A+D G+P  ++S+  V V+V
Sbjct: 964  YSLLD-HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEV 1022

Query: 556  LDVNDN--EPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLG 613
            +DVN+N   P+F S   + TV E+ P+G  V+ + A D D+  +  + Y + D       
Sbjct: 1023 VDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRD------- 1075

Query: 614  GGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSV 673
            G   G           F+I   +G I     LDRE   HY   V A D G  P+SS   +
Sbjct: 1076 GSGVG----------VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEI 1125

Query: 674  SITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRN 731
             I V DVNDN P  ++P Y   + E++    SV+ ++A D D  +N  + Y++T GN + 
Sbjct: 1126 YIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQG 1185

Query: 732  RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPV 788
             F++   + G + T +  LD +Q+ +++L VT +D     +S  A V++ + D N ++P 
Sbjct: 1186 FFSI-HPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQ 1244

Query: 789  FQSSHYTVSVSE----DRPVGT---SIATLSANDEDTGENARITYVIQD--PVPQFRIDP 839
            F    Y + + E    DR        +  + A D+D G NA I+Y I+D     +F I+P
Sbjct: 1245 FLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEP 1304

Query: 840  DSGTMYTMMELDYENQVAY-TLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ---FLWD 895
             +G + +     +     Y  L+I A DNG PQKS TT L I  +     + +   F   
Sbjct: 1305 KTGVVSSKR---FSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEES 1361

Query: 896  FYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRR 955
            F+  ++ E  P +  I  +S       P G  L+    G + D  F ++  +G I   + 
Sbjct: 1362 FFTFTVMESDPVAHMIGVISVE-----PPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKP 1416

Query: 956  LDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVG 1015
            LD E  + YNL   A D G+ T L+   ++ + ++D ND+ P F   + E+ + E+    
Sbjct: 1417 LDAEQKSNYNLTVEATD-GTTTILT---QVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPE 1472

Query: 1016 SVVAKIRANDPDEGPNAQIMYQIVEGDMR-HFFQLDLLNGDLRAMVELDFEVRREYVLVV 1074
            + + +I A D DE        Q     +    F+LD   G L    +LD E   ++ L V
Sbjct: 1473 TEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTV 1532

Query: 1075 QATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCIPAHDPD 1133
                  +  +     ++V+ +D     P F    ++Y      S   G V+  + A D D
Sbjct: 1533 MVRDQDVPVKRNFARIVVNVSDTNDHAPWFTA--SSYKGRVYESAAVGSVVLQVTALDKD 1590

Query: 1134 VSDSLN--YTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTAF 1190
               +    Y+   GN     ++DP  G ++ +++LD +   E  + V  +D G   ++  
Sbjct: 1591 KGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEI 1650

Query: 1191 CTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAA-----VLSTTKD----D 1241
             ++R+ +   D  +   T +  ++   + +S  +  FV  V A     V+   KD    D
Sbjct: 1651 TSVRIFVTIADNASPKFTSKEYSVELSETVS--IGSFVGMVTAHSQSSVVYEIKDGNTGD 1708

Query: 1242 VFVFNVQNDTDVSSNILN 1259
             F  N  + T ++   L+
Sbjct: 1709 AFDINPHSGTIITQKALD 1726



 Score =  357 bits (917), Expect = 8e-98
 Identities = 287/1018 (28%), Positives = 471/1018 (46%), Gaps = 55/1018 (5%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +F    Y+V +  +   GT ++++ A    EG    ++Y +E    E  +    I+  +G
Sbjct: 2595 QFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEA-DSESVKENLEINKLSG 2653

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
             ++T   L     E     V+AVD  +P + +   + V +       P F +  Y   V 
Sbjct: 2654 VITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVS 2713

Query: 364  ENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV-FQLNESSGVVSTRAVLDREEAAE 422
            E++ +G E+  IRA    + + + ++        D  F ++  SG +     LD E    
Sbjct: 2714 EDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKW 2773

Query: 423  YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ 482
            YQ  + A    ++   + A+  V I+V+D NDN P F    Y   + E++   + V++++
Sbjct: 2774 YQFSILARCT-QDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIR 2832

Query: 483  ATDRDQGQNAAIHYSI---LSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDG 539
            A+D D G N  + YS+    S  V   F ++  +G +  +  LD E    Y + + A D 
Sbjct: 2833 ASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH 2892

Query: 540  GRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE-NA 598
            G    ++S+ +V V V DVND+ P F +  ++ TV E+ P G  +  +   DADS E N 
Sbjct: 2893 GEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINR 2952

Query: 599  RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658
            ++ Y        F+ GG        P   F  +   +   + V   LDRE+ ++Y   + 
Sbjct: 2953 QVTY--------FITGGD-------PLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTIT 2997

Query: 659  AVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--A 716
            A D      SS   V + VLD NDN PV  +  Y   + ED   G  ++ + A D D  +
Sbjct: 2998 ATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRS 3054

Query: 717  NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-RSHTAHV 775
            N+ ITY L G     +F L+   G   +  + PLD +++  Y L V A+DG  R   A +
Sbjct: 3055 NAEITYTLLGSGAE-KFKLNPDTGE--LKTSTPLDREEQAVYHLLVRATDGGGRFCQASI 3111

Query: 776  LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVP-Q 834
            ++ + D N + P F +  Y ++V E+   GT +  + A D D G N +I Y + D    Q
Sbjct: 3112 VLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQ 3171

Query: 835  FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTT-TLEILILDANDNAPQFL 893
            F I+  SG +     LD E Q  YTL++ A D G+P++   T T+ + +LD NDN P F 
Sbjct: 3172 FSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFE 3231

Query: 894  WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ 953
            +  Y  ++ ED    T +LQV A  RD   N  + Y+   G++  G F I+  +G +   
Sbjct: 3232 YREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNE-HGKFSIDSKTGAVFII 3290

Query: 954  RRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNP 1013
              LD E+   Y L   A D G+P+ LS    + V + DINDN P+F +D     + E+  
Sbjct: 3291 ENLDYESSHEYYLTVEATDGGTPS-LSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAV 3349

Query: 1014 VGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLV 1073
            +   V  + A+D D   N+ I Y I++G+    F +D + G+++    LD E    Y L 
Sbjct: 3350 LEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLT 3409

Query: 1074 VQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGV-IGCIPA 1129
            VQA+   S P V+  TV+I + D NDN PV         NY      + P G  +  +  
Sbjct: 3410 VQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSR-----GNYSVIIQENKPVGFSVLQLVV 3464

Query: 1130 HDPDVSDS---LNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIH 1185
             D D S +     +T V GN+ +   ++P  G L  S  +        L++V V+D G  
Sbjct: 3465 TDEDSSHNGPPFFFTIVTGNDEKAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVADNGKP 3523

Query: 1186 SVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVF 1243
             +++   + + +I + +   +I      +  E F++     +  GV   +  T  DV+
Sbjct: 3524 QLSSLTYIDIRVIEESIYPPAI------LPLEIFITSSGEEYSGGVIGKIHATDQDVY 3575



 Score =  353 bits (905), Expect = 2e-96
 Identities = 323/1127 (28%), Positives = 502/1127 (44%), Gaps = 120/1127 (10%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +F    Y+ A  EN P GT ++ L A    EGE   V+Y +  L    +   F ID  TG
Sbjct: 462  EFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANL----NHVPFAIDHFTG 517

Query: 304  AVSTDSVLDRETK-ETHVLRVKAVDYSTPPRSATTYI-TVLVKDTNDHSPVFEQSEYRER 361
            AVST   LD E     + LR++A D+  P R     + T+ + + ND++P+FE+      
Sbjct: 518  AVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGT 577

Query: 362  VRENLEVGYEVLTIRASDRDSPINANLRYRV-LGGAWDVFQLNESSGVVST-RAVLDR-- 417
            +  +L VG ++ T+ A D D      ++Y++  G   D F LN +SGV+S  R+++D   
Sbjct: 578  IPRDLGVGEQITTVSAIDADEL--QLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLG 635

Query: 418  EEAAEYQLLVEANDQGRNPGPLSATATVYI------------------------------ 447
             + + + L + A D      PL    TV                                
Sbjct: 636  AKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHN 695

Query: 448  --EVED-------ENDNYPQF-SEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYS 497
              EVED        N + PQF S     +QV E+  + ++V+ + +TD D G N  + Y+
Sbjct: 696  QGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYA 755

Query: 498  ILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLD 557
            +  GN    F +   +G+L +++PLD E   KY+L+I   D G P    +  ++ V V+D
Sbjct: 756  VSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKA-AWRLLHVVVVD 814

Query: 558  VNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSA 617
             NDN P F+   +   V E+  +   ++ ++A D D G N  + Y +V    T       
Sbjct: 815  ANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT------- 867

Query: 618  GPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG--SPPMSSSTSVSI 675
                        F I + +G + +   LDRE    +S  +EA D     P + S+  V +
Sbjct: 868  ------------FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKV 915

Query: 676  TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733
            ++ DVNDN P F  P Y +++ ED   G+ ++ L+A D D   +  + Y L      N  
Sbjct: 916  SLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN-- 973

Query: 734  ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR----SHTAHVLINVTDA--NTHRP 787
                 +  G + +   LD++++Q Y L V A D  +    S T +V + V D   N H P
Sbjct: 974  -FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPP 1032

Query: 788  VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD--PVPQFRIDPDSGTMY 845
            VF S     +V ED PVG+ + T+SA+DED   +  I Y I+D   V  F+I  ++G + 
Sbjct: 1033 VFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIE 1092

Query: 846  TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905
            T   LD E+   Y LT+ A D G+   S    + I + D NDNAPQ     Y   I E++
Sbjct: 1093 TSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENS 1152

Query: 906  PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVI-RTQRRLDRENVAVY 964
            P   S++Q+ A D DS  N +L+Y    G+   G F I P +G+I  T R+LDRE    +
Sbjct: 1153 PKDVSVVQIEAFDPDSSSNDKLMYKITSGNP-QGFFSIHPKTGLITTTSRKLDREQQDEH 1211

Query: 965  NLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF-------EKDELELFVEENNPVGSV 1017
             L     D GSP P S    + V ILD NDN P F          E E    E N     
Sbjct: 1212 ILEVTVTDNGSP-PKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREP 1270

Query: 1018 VAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREY-VLVVQA 1076
            +  + A D DEGPNA+I Y I +G+    F ++   G    +    F    EY +L ++A
Sbjct: 1271 LYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG---VVSSKRFSAAGEYDILSIKA 1327

Query: 1077 --TSAPLVSRAT-VHILLVDQNDNPPVLP-DFQILFNNYVTNKSNSFPTGVIGCIPAHDP 1132
                 P  S  T +HI  + +   P + P  F+  F  +   +S+     +IG I    P
Sbjct: 1328 VDNGRPQKSSTTRLHIEWISK-PKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPP 1385

Query: 1133 DVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCT 1192
             +   L +    GN      +D  TG + +++ LD  +     + V  +DG  ++     
Sbjct: 1386 GI--PLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVF 1443

Query: 1193 LRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTD 1252
            ++V I T+D      T + E +  E        L +  V       + +  ++ +Q+  D
Sbjct: 1444 IKV-IDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAV----DQDEKNKLIYTLQSSRD 1498

Query: 1253 VSSNILNVTFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRV 1299
                 L++    L P    G  + SE L  +     TL   +  Q V
Sbjct: 1499 P----LSLKKFRLDP--ATGSLYTSEKLDHEAVHQHTLTVMVRDQDV 1539



 Score =  341 bits (875), Expect = 6e-93
 Identities = 278/980 (28%), Positives = 472/980 (48%), Gaps = 67/980 (6%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F   +Y V L E    GT ++Q+ A  +       +SY M G    +S  +F +DS+TG 
Sbjct: 2283 FAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHS-KSHDHFHVDSSTGL 2341

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
            +S    LD E    H + V+AVD   P  S+   +TV V D ND+ P+FEQ  Y  R+ E
Sbjct: 2342 ISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401

Query: 365  NLEVGYEVLTIRASDRDSPINANLRYRVL-GGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
            +   G+ V  ++A D DS     L+Y +L G     F ++ ++G+++   +        Y
Sbjct: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFY 2461

Query: 424  QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQA 483
             L +  +D     G   ++  V++ V   N + P F +  Y V++ E+  L+T V+ V+ 
Sbjct: 2462 SLNLSVSD-----GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKT 2516

Query: 484  TDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK--AQDGGR 541
            TD D G    + Y I++     +FY++   G +  +  LD E   +  +S++  A+D G 
Sbjct: 2517 TDGDSGIYGHVTYHIVNDFAKDRFYINE-RGQIFTLEKLDRETPAEKVISVRLMAKDAGG 2575

Query: 542  PPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLH 601
                 +   V+V + D NDN P F ++ ++  +  +   G  VV + A DAD G NA + 
Sbjct: 2576 KVAFCT---VNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADIT 2632

Query: 602  YRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVD 661
            Y +   + +                    +I+  SG IT    L   E E ++F V AVD
Sbjct: 2633 YAIEADSESVKEN---------------LEINKLSGVITTKESLIGLENEFFTFFVRAVD 2677

Query: 662  HGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVIT 721
            +GSP   S   V + +L      P F++P Y   ++ED  +G+ +  ++A   + +  + 
Sbjct: 2678 NGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA---EHSGTVL 2734

Query: 722  YQLTGGNT--RNR-FALSSQRGGGLITLALPLDYKQEQQYVLAV----TASDGTRSHTAH 774
            Y L  GNT   NR  +    R  G + L   LD++  + Y  ++    T  D     +  
Sbjct: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVD 2794

Query: 775  VLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ----- 829
            V I V DAN + PVF+SS Y   + E+ P G+ +  + A+D D+G N ++ Y +      
Sbjct: 2795 VSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSV 2854

Query: 830  DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP-QKSDTTTLEILILDANDN 888
            + +  F I+ ++G + T+ ELD+E +  Y + ++A D+G   Q S T  +++ + D ND+
Sbjct: 2855 EVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDS 2914

Query: 889  APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG 948
             P+F  + Y+G++ ED P    I  +S TD DS    R +  F  G D  G F +E    
Sbjct: 2915 PPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQN 2974

Query: 949  --VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL 1006
               +  ++ LDRE    Y L   A D       S+   ++V +LD NDN+P+ EK     
Sbjct: 2975 EWKVYVKKPLDREKRDNYLLTITATD----GTFSSKAIVEVKVLDANDNSPVCEKTLYSD 3030

Query: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV 1066
             + E+   G ++ +I A D D   NA+I Y ++ G     F+L+   G+L+    LD E 
Sbjct: 3031 TIPEDVLPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTSTPLDREE 3089

Query: 1067 RREYVLVVQAT-SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNY-VTNKSNSFPTGVI 1124
            +  Y L+V+AT       +A++ + L D NDN P     +   + Y +T   N+ P  ++
Sbjct: 3090 QAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAP-----EFSADPYAITVFENTEPGTLL 3144

Query: 1125 GCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVS--- 1179
              + A D D  ++  + Y+ +   + +   ++  +G +QL + LD  R L+A+  +S   
Sbjct: 3145 TRVQATDADAGLNRKILYSLIDSADGQ-FSINELSGIIQLEKPLD--RELQAVYTLSLKA 3201

Query: 1180 VSDGI-HSVTAFCTLRVTII 1198
            V  G+   +TA  T+ V+++
Sbjct: 3202 VDQGLPRRLTATGTVIVSVL 3221



 Score =  331 bits (849), Expect = 6e-90
 Identities = 292/1032 (28%), Positives = 466/1032 (45%), Gaps = 117/1032 (11%)

Query: 198  LALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFEN 257
            L L+A   GTP    S    +    P+ +AGP +  +       S +F  PN  V + + 
Sbjct: 334  LTLQAKDKGTPPQFSSVKV-IHVTSPQFKAGPVKFEKDVYRAEIS-EFAPPNTPVVMVKA 391

Query: 258  EPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKE 317
             PA +     H  Y  +    +                F ++  TG +S    + R+   
Sbjct: 392  IPAYS-----HLRYVFKSTPGKAK--------------FSLNYNTGLISILEPVKRQQAA 432

Query: 318  THVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRA 377
               L V     +T  R A+T + V V   N + P F Q+ Y+    EN+ +G  V+++ A
Sbjct: 433  HFELEV-----TTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSA 487

Query: 378  SDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAE-YQLLVEANDQGRNP 436
             D D   N  + Y +       F ++  +G VST   LD E     Y L + A+D G  P
Sbjct: 488  VDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGL-P 546

Query: 437  GPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHY 496
                      I + + NDN P F + N    +P D+G+   +  V A D D+ Q   + Y
Sbjct: 547  YRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ--LVQY 604

Query: 497  SILSGNVAGQFYLHSLSGILDVINPLD---FEDVQKYSLSIKAQDG---GRPPLINSSGV 550
             I +GN    F L+  SG+L +   L       V  +SL I A DG     P  IN +  
Sbjct: 605  QIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVA 664

Query: 551  VSVQVLD-------------------------------------VNDNEPIFVSS-PFQA 572
             S ++++                                     VN + P F S+ P   
Sbjct: 665  ASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGI 724

Query: 573  TVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQI 632
             V EN P+G  V+ + + D D+G N +L Y         + GG+          D  F I
Sbjct: 725  QVKENQPVGSSVIFMNSTDLDTGFNGKLVYA--------VSGGN---------EDSCFMI 767

Query: 633  HNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTY 692
               +G + + + LDRE  + Y+  +   D G P  ++   + + V+D NDN P F Q +Y
Sbjct: 768  DMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESY 827

Query: 693  ELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPL 750
             + ++ED  V S ++ ++A D+D   N  +TY +      + F++ S    G++ +A PL
Sbjct: 828  FVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV--TDTDTFSIDSVT--GVVNIARPL 883

Query: 751  DYKQEQQYVLAVTASDGTRSH-----TAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVG 805
            D + + ++ L + A D  R       T  V +++ D N + P F   +Y V V ED P G
Sbjct: 884  DRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEG 943

Query: 806  TSIATLSANDEDTGENARITYVIQD-PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMA 864
            T I  L A+D D G++ ++ Y + D     F +D  SG +  + +LD+E +  Y LT+ A
Sbjct: 944  TVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA 1003

Query: 865  QDNGIP-QKSDTTTLEILILDANDN--APQFLWDFYQGSIFEDAPPSTSILQVSATDRDS 921
            +D G P   S T  +E+ ++D N+N   P F     +G++ EDAP  + ++ VSA D D+
Sbjct: 1004 KDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDA 1063

Query: 922  GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981
              +G + Y+ + G  G G F I   +GVI T  RLDRE+ + Y L   A D+G   PLS+
Sbjct: 1064 RRDGEIRYSIRDG-SGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQG-VVPLSS 1121

Query: 982  SVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEG 1041
             +EI + + D+NDNAP   +      + EN+P    V +I A DPD   N ++MY+I  G
Sbjct: 1122 FIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSG 1181

Query: 1042 DMRHFFQLDLLNGDLRAMV-ELDFEVRREYVLVVQAT---SAPLVSRATVHILLVDQNDN 1097
            + + FF +    G +     +LD E + E++L V  T   S P  + A V + ++D+NDN
Sbjct: 1182 NPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDN 1241

Query: 1098 -PPVLPDFQ--ILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDS--LNYTFVQGNELRLLL 1152
             P  L  F    L      ++  +     +  + A D D   +  ++Y+   GNE     
Sbjct: 1242 KPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFF 1301

Query: 1153 LDPATGELQLSR 1164
            ++P TG +   R
Sbjct: 1302 IEPKTGVVSSKR 1313



 Score =  291 bits (744), Expect = 9e-78
 Identities = 241/863 (27%), Positives = 398/863 (46%), Gaps = 63/863 (7%)

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSA--TTYITVLVKDTNDHSPV 352
            YF IDS+TGA+ T   LD E        V+  D  TP   A     +TV V D ND  PV
Sbjct: 1819 YFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPV 1878

Query: 353  FEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVL-GGAWDVFQLNESSGVVST 411
            F +  Y   +      G +V+T+ A+D DS   + L Y +  G   + F ++  +G ++ 
Sbjct: 1879 FAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTV 1938

Query: 412  RAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPED 471
            +        + Y+L V A+D     G  +   +V I V++  +++ +F++  Y   V E+
Sbjct: 1939 QNTTQLR--SRYELTVRASD-----GRFAGLTSVKINVKESKESHLKFTQDVYSAVVKEN 1991

Query: 472  VGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN-PLDFEDVQKY 530
                  +  + A       N  + Y IL  N   +F +   SG+L     P D E  + +
Sbjct: 1992 STEAETLAVITAIGNPI--NEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFDREQQEAF 2047

Query: 531  SLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAV 590
             + ++  +  +P  + +  VV V V D NDN P+FV+ P+ A V  +  +G+ + ++ AV
Sbjct: 2048 DVVVEVTEEHKPSAV-AHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAV 2106

Query: 591  DADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEV 650
            D DSG N  +HY L +    F      GP                 G I++  + + + +
Sbjct: 2107 DRDSGRNGEVHYYLKEHHEHF----QIGP----------------LGEISLKKQFELDTL 2146

Query: 651  -EHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTL 709
             + Y   V A D G+P  S+   V ITV+  N   PVF +P Y   + E   V S V+ +
Sbjct: 2147 NKEYLVTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFYSAEIAESIQVHSPVVHV 2204

Query: 710  QARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR 769
            QA   +   V  Y +T G+  ++F ++     G+I +  PLD++    Y L++ A+D   
Sbjct: 2205 QANSPEGLKVF-YSITDGDPFSQFTINFNT--GVINVIAPLDFEAHPAYKLSIRATDSLT 2261

Query: 770  SHTAHVLIN--VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYV 827
               A V ++  V D N + PVF    Y V++SE   +GTS+  + A D D+  N  I+Y 
Sbjct: 2262 GAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQ 2321

Query: 828  I----QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILIL 883
            +          F +D  +G +  +  LDYE    +T+ + A D G+P  S    + + + 
Sbjct: 2322 MFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVT 2381

Query: 884  DANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYI 943
            D NDN P F    Y+  I E AP    +  V A D DS    +L Y+   G+D    F I
Sbjct: 2382 DLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGND-HKHFVI 2440

Query: 944  EPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDE 1003
            +  +G+I T   L R  +  +    L+V  G      +S ++ VT++  N ++P F ++E
Sbjct: 2441 DSATGII-TLSNLHRHALKPFYSLNLSVSDG---VFRSSTQVHVTVIGGNLHSPAFLQNE 2496

Query: 1004 LELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELD 1063
             E+ + EN P+ ++V +++  D D G    + Y IV    +  F ++   G +  + +LD
Sbjct: 2497 YEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLD 2555

Query: 1064 FEVRREYVLVVQATSAPL---VSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFP 1120
             E   E V+ V+  +      V+  TV+++L D NDN P     Q     Y  N  +S  
Sbjct: 2556 RETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAP-----QFRATKYEVNIGSSAA 2610

Query: 1121 TGV-IGCIPAHDPDVSDSLNYTF 1142
             G  +  + A D D   + + T+
Sbjct: 2611 KGTSVVKVLASDADEGSNADITY 2633



 Score =  258 bits (659), Expect = 6e-68
 Identities = 255/998 (25%), Positives = 429/998 (42%), Gaps = 127/998 (12%)

Query: 243  LKFPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEER---VSYYMEGLF--DERSRG 294
            L+F    Y V + EN  A T +   +++  + T    E R   VS   E LF  +E   G
Sbjct: 32   LQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILG 91

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
             F            ++L+RE K+ + L VKA++ +T    A T + V V DTND  P+F 
Sbjct: 92   DFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVE-ARTKVRVQVLDTNDLRPLFS 150

Query: 355  QSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAV 414
             + Y   + EN  +   +  + A+D D   N    Y       D+F ++ +SGV+     
Sbjct: 151  PTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYS-FKDRTDMFAIHPTSGVIVLTGR 209

Query: 415  LDREEAAEYQLLVEANDQGR---NPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPED 471
            LD  E   Y++ + A D+G        +S+ A + + +E  N+  P  +    V   P +
Sbjct: 210  LDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA---VTLSPSE 266

Query: 472  VGLNTAVLRVQATDRDQGQNAAI-HYSILSGNVAGQF-YLHSLSGI----LDVINPLDFE 525
            +  + A   V   D DQG N  I   SI++G++  QF  + S  G     +  I  +D++
Sbjct: 267  LDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWD 326

Query: 526  DVQ-KYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV 584
                 Y+L+++A+D G PP  +S  V+ V           F    ++A + E  P   PV
Sbjct: 327  SHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV 386

Query: 585  VHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE 644
            V ++A+ A S      H R V  ++     G A            F ++ ++G I++   
Sbjct: 387  VMVKAIPAYS------HLRYVFKSTP----GKA-----------KFSLNYNTGLISILEP 425

Query: 645  LDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGS 704
            + R++  H+   V   D       +ST V + VL  N N P FTQ  Y+   +E+  +G+
Sbjct: 426  VKRQQAAHFELEVTTSDR-----KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGT 480

Query: 705  SVLTLQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK-QEQQYVLA 761
            +V++L A D D   N  +TY +      N    +     G ++ +  LDY+   + Y L 
Sbjct: 481  TVMSLSAVDPDEGENGYVTYSIA---NLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLR 537

Query: 762  VTASDGTRSHTAHV----LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDED 817
            + ASD    +   V     I + + N + P+F+  +   ++  D  VG  I T+SA D D
Sbjct: 538  IRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD 597

Query: 818  TGENARITYVIQDPVPQFRIDPDSGTMYTMMEL---------------------DYENQV 856
              +  +      + +  F ++P+SG +     L                     ++   +
Sbjct: 598  ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPL 657

Query: 857  AYTLTIMAQDNGIPQKSDTTTLEILILD-----------------------ANDNAPQFL 893
               +T+ A    +  + + T +  ++ +                        N + PQF 
Sbjct: 658  YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717

Query: 894  WDFYQG-SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRT 952
                 G  + E+ P  +S++ +++TD D+G NG+L+Y   GG++ D  F I+  +G+++ 
Sbjct: 718  STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNE-DSCFMIDMETGMLKI 776

Query: 953  QRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENN 1012
               LDRE    Y L     D G P   +  + + V ++D NDN P F ++   + V E+ 
Sbjct: 777  LSPLDRETTDKYTLNITVYDLGIPQKAAWRL-LHVVVVDANDNPPEFLQESYFVEVSEDK 835

Query: 1013 PVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVL 1072
             V S + ++ A D D GPN  + Y IV       F +D + G +     LD E++ E+ L
Sbjct: 836  EVHSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDRELQHEHSL 893

Query: 1073 VVQA-----TSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGC 1126
             ++A         L S   V + L D NDNPP       +  NY        P G VI  
Sbjct: 894  KIEARDQAREEPQLFSTVVVKVSLEDVNDNPPT-----FIPPNYRVKVREDLPEGTVIMW 948

Query: 1127 IPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSR 1164
            + AHDPD+         Q  ++R  LLD   G   + +
Sbjct: 949  LEAHDPDLG--------QSGQVRYSLLDHGEGNFDVDK 978



 Score =  167 bits (424), Expect = 1e-40
 Identities = 171/638 (26%), Positives = 284/638 (44%), Gaps = 73/638 (11%)

Query: 627  DFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPV 686
            DF F    + G  T  A L+RE  +HY+  V+A++  +  + + T V + VLD ND  P+
Sbjct: 92   DFCFLRIRTKGGNT--AILNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPL 148

Query: 687  FTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITL 746
            F+  +Y + L E+ A+ +S+  + A D D  +   +  +  +  + FA+      G+I L
Sbjct: 149  FSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPT--SGVIVL 206

Query: 747  ALPLDYKQEQQYVLAVTASD-GTR-------SHTAHVLINVTDANTHRPVFQSSHYTVSV 798
               LDY + + Y + + A+D G +       S  A + +++  AN   PV  +   T+S 
Sbjct: 207  TGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA--VTLSP 264

Query: 799  SE-DRPVGTSIATLSANDEDT-GENARITYVIQDPVPQFR-IDPDSGTMYTMME----LD 851
            SE DR    +I T+   D+   G+ A ++ V  D + QFR +    G+    ++    +D
Sbjct: 265  SELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGID 324

Query: 852  YENQ-VAYTLTIMAQDNGIP-QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPST 909
            +++    Y LT+ A+D G P Q S    + +          +F  D Y+  I E APP+T
Sbjct: 325  WDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNT 384

Query: 910  SILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWAL 969
             ++ V A    S     L Y F+    G   F +   +G+I     + R+  A + L   
Sbjct: 385  PVVMVKAIPAYS----HLRYVFKS-TPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVT 439

Query: 970  AVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEG 1029
              DR       AS ++ V +L  N N P F +   +   +EN P+G+ V  + A DPDEG
Sbjct: 440  TSDR------KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEG 493

Query: 1030 PNAQIMYQIVEGDMRHF-FQLDLLNGDLRAMVELDFEVR-REYVLVVQATSAPLVSRATV 1087
             N  + Y I   ++ H  F +D   G +     LD+E+  R Y L ++A+   L  R  V
Sbjct: 494  ENGYVTYSIA--NLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREV 551

Query: 1088 HIL----LVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGV-----IGCIPAHDPDVSDSL 1138
             +L    L + NDN P+             N   + P  +     I  + A D D    +
Sbjct: 552  EVLATITLNNLNDNTPLFEKI---------NCEGTIPRDLGVGEQITTVSAIDADELQLV 602

Query: 1139 NYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTII 1198
             Y    GNEL    L+P +G L L R              S+ DG+ +  +F +LR+T  
Sbjct: 603  QYQIEAGNELDFFSLNPNSGVLSLKR--------------SLMDGLGAKVSFHSLRITAT 648

Query: 1199 TDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLS 1236
              +     + + +   +  K ++  L     GVA +L+
Sbjct: 649  DGENFATPLYINITVAASHKLVN--LQCEETGVAKMLA 684



 Score = 96.7 bits (239), Expect = 3e-19
 Identities = 115/478 (24%), Positives = 183/478 (38%), Gaps = 51/478 (10%)

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALP--------LDYKQEQQYVLAVTASDGTRSH 771
            + Y++  G++ N F       G    L +         L+ + +  Y L V A +   + 
Sbjct: 70   VRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNV 129

Query: 772  TAH--VLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
             A   V + V D N  RP+F  + Y+VS+ E+  + TSIA +SA D D G N    Y  +
Sbjct: 130  EARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFK 189

Query: 830  DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK-----SDTTTLEILILD 884
            D    F I P SG +     LDY     Y + I+A D G+        S    L + I  
Sbjct: 190  DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQ 249

Query: 885  ANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLL-YTFQGGD-------- 935
            AN+ AP         S   D  P+ +I  V+  D D G NG +   +   GD        
Sbjct: 250  ANECAPVITAVTLSPSEL-DRDPAYAI--VTVDDCDQGANGDIASLSIVAGDLLQQFRTV 306

Query: 936  ---DGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDI 992
                G  ++ ++   G+              YNL   A D+G+P   S+   I VT    
Sbjct: 307  RSFPGSKEYKVKAIGGIDWDSHPFG------YNLTLQAKDKGTPPQFSSVKVIHVTSPQF 360

Query: 993  NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLL 1052
                  FEKD     + E  P  + V  ++A        + + Y       +  F L+  
Sbjct: 361  KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIP----AYSHLRYVFKSTPGKAKFSLNYN 416

Query: 1053 NGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYV 1112
             G +  +  +  +    + L V  +     ++  V +L    N NPP     +     Y 
Sbjct: 417  TGLISILEPVKRQQAAHFELEVTTSDRKASTKVLVKVL--GANSNPP-----EFTQTAYK 469

Query: 1113 TNKSNSFPTG-VIGCIPAHDPDVSDS--LNYTFVQGNELRLLLLDPATGELQLSRDLD 1167
                 + P G  +  + A DPD  ++  + Y+    N +    +D  TG +  S +LD
Sbjct: 470  AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLD 526



 Score = 86.7 bits (213), Expect = 3e-16
 Identities = 108/419 (25%), Positives = 159/419 (37%), Gaps = 54/419 (12%)

Query: 1643 REG-CAARRNFCDGRRCQNGGTCVNR-WN-MYLCECPL-RFGGKNCEQAMPHPQLFSGES 1698
            +EG C    + C+   C  G  CV+  W   + C CP  RFG      +M      +G S
Sbjct: 3783 KEGRCPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMT----LTGNS 3838

Query: 1699 VVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSD 1758
             V +        +   L +  RT    +V+M A   G     L+I +  LQ++   G S 
Sbjct: 3839 YVKYRLTENENKLEMKLTMRLRTYSTHAVVMYAR--GTDYSILEIHHGRLQYKFDCG-SG 3895

Query: 1759 VESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTV 1818
               V +  ++V DG+WH + +E+          +   + LD  +        G L  L +
Sbjct: 3896 PGIVSVQSIQVNDGQWHAVALEVNG--------NYARLVLDQ-VHTASGTAPGTLKTLNL 3946

Query: 1819 RSVVVGGASEDKVSVR--------RGFRGCMQGVRMGGTPTNVATLNMNNA---LKVRVK 1867
             + V  G    +   R         GFRGCM  + + G    + +   + A     V V 
Sbjct: 3947 DNYVFFGGHIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVS 4006

Query: 1868 DGC--DVDDPCTSSPCPPNSRCHDA-WEDYSCVCDKGYLGINC---VDACHLNPCENMGA 1921
             GC     + C S+PC     C+ +    Y C C   Y+G +C   V+ C   PC   G 
Sbjct: 4007 PGCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGT 4066

Query: 1922 CVRSPGSPQGYVCECGPSHYG------PYCENKLDLPCPRGWWGNPVCGPCHCAVSKGFD 1975
            CV   G   G+VC+C   + G      PYC+   D PC  G           C    GF 
Sbjct: 4067 CVVDNG---GFVCQCRGLYTGQRCQLSPYCK---DEPCKNGGTCFDSLDGAVCQCDSGFR 4120

Query: 1976 PD-CNKTNGQCQCKENYYKLLAQDT--CLPCDCFPHGSHSRTC-DMATGQCACKPGVIG 2030
             + C     +C      +  L ++T     C+C  H    R C D A  Q    P  IG
Sbjct: 4121 GERCQSDIDECSGNPCLHGALCENTHGSYHCNC-SHEYRGRHCEDAAPNQYVSTPWNIG 4178



 Score = 72.4 bits (176), Expect = 6e-12
 Identities = 34/91 (37%), Positives = 47/91 (51%), Gaps = 4/91 (4%)

Query: 1343 PINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDA 1402
            P  G  C+C   + G +CE  ++ C S PC   G C    GG+ C+C   +TG+ C++  
Sbjct: 4032 PAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQL-- 4089

Query: 1403 RSGRCANGVCKNGGTCVNLLIGGFHCVCPPG 1433
             S  C +  CKNGGTC + L G   C C  G
Sbjct: 4090 -SPYCKDEPCKNGGTCFDSLDGAV-CQCDSG 4118



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 30/93 (32%), Positives = 42/93 (45%), Gaps = 22/93 (23%)

Query: 1307 CLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDL 1366
            C  EPC+N   C     FDS                 ++G  C+C  GF G+ C+++ID 
Sbjct: 4093 CKDEPCKNGGTC-----FDS-----------------LDGAVCQCDSGFRGERCQSDIDE 4130

Query: 1367 CYSDPCGANGRCRSREGGYTCECFEDFTGEHCE 1399
            C  +PC     C +  G Y C C  ++ G HCE
Sbjct: 4131 CSGNPCLHGALCENTHGSYHCNCSHEYRGRHCE 4163



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 43/152 (28%), Positives = 60/152 (39%), Gaps = 22/152 (14%)

Query: 1307 CLREPCEN------------YMKCVSVL---RFDSSAPFLSSTTVLFRPIHPIN--GLRC 1349
            C   PC+N            Y KC ++      + S    SS   L+     ++  G  C
Sbjct: 4017 CASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVC 4076

Query: 1350 RCPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCAN 1409
            +C   +TG  C+     C  +PC   G C     G  C+C   F GE C+ D     C+ 
Sbjct: 4077 QCRGLYTGQRCQLS-PYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDI--DECSG 4133

Query: 1410 GVCKNGGTCVNLLIGGFHCVCPPGEYERPYCE 1441
              C +G  C N   G +HC C   EY   +CE
Sbjct: 4134 NPCLHGALCEN-THGSYHCNC-SHEYRGRHCE 4163



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 22/74 (29%), Positives = 30/74 (40%), Gaps = 16/74 (21%)

Query: 1644 EGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWS 1703
            E C +  + C G  C +G  C N    Y C C   + G++CE A P              
Sbjct: 4122 ERCQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDAAP-------------- 4167

Query: 1704 DLNIIISVPWYLGL 1717
              N  +S PW +GL
Sbjct: 4168 --NQYVSTPWNIGL 4179



 Score = 37.0 bits (84), Expect = 0.30
 Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 2/57 (3%)

Query: 1631 VDMAGFIAN-NGTREGCAARRN-FCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCE 1685
            VD  GF+    G   G   + + +C    C+NGGTC +  +  +C+C   F G+ C+
Sbjct: 4069 VDNGGFVCQCRGLYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQ 4125



 Score = 36.2 bits (82), Expect = 0.50
 Identities = 45/198 (22%), Positives = 84/198 (42%), Gaps = 27/198 (13%)

Query: 1003 ELELFVEENNPVGSVVAK-IRANDPDEGPNAQIMYQIVEGDMRHFFQL-DLLNGD---LR 1057
            E  + V+EN+   + V   ++       P  ++ Y+IV GD  + F+  + + GD   LR
Sbjct: 38   EYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDFCFLR 97

Query: 1058 AMVE------LDFEVRREYVLVVQA--TSAPLVSRATVHILLVDQNDNPPVLPDFQILFN 1109
               +      L+ EV+  Y L+V+A   +  + +R  V + ++D ND  P+         
Sbjct: 98   IRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSP------ 151

Query: 1110 NYVTNKSNSFPTGV-----IGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSR 1164
               T+ S S P        I  + A D D+  +  + +   +   +  + P +G + L+ 
Sbjct: 152  ---TSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTG 208

Query: 1165 DLDNNRPLEALMEVSVSD 1182
             LD        ME+  +D
Sbjct: 209  RLDYLETKLYEMEILAAD 226


>gi|16933557 dachsous 1 precursor [Homo sapiens]
          Length = 3298

 Score =  414 bits (1065), Expect = e-115
 Identities = 335/1018 (32%), Positives = 483/1018 (47%), Gaps = 86/1018 (8%)

Query: 175  PGGSVRLRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRAR 234
            P   VR RLL   R+      + L         P      + P    L EA   PA  +R
Sbjct: 1468 PNSDVRYRLL---RQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASR 1524

Query: 235  RGTSGRGSLK------------FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSY 282
            R  + R S +            F  P+ +V L E++P G   L + A     GE  RVSY
Sbjct: 1525 R-RAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSY 1582

Query: 283  YMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVL 342
             +    D    G+FR+ S+TGA+S    LDRE +  HVL V A D+ +PPRSAT  +TV 
Sbjct: 1583 RLASGGD----GHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVS 1638

Query: 343  VKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQL 402
            V D ND +P F+Q EY   +REN   G  +LT+RA+D D   N  + Y   G + + F L
Sbjct: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYG--GVSSESFSL 1696

Query: 403  NESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQ 462
            +  +GV++T   LDREE  E  L V A D+G    P     TV + VEDEND+ P F   
Sbjct: 1697 DPDTGVLTTLRALDREEQEEINLTVYAQDRG--SPPQLTHVTVRVAVEDENDHAPTFGSA 1754

Query: 463  NYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPL 522
            +  ++VPE     T  + ++A+D D G N  + Y IL G+ +G F L   SG    + PL
Sbjct: 1755 HLSLEVPEGQDPQTLTM-LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPL 1813

Query: 523  DFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGY 582
            D E    + L I+A+DGG+P L +++ +++V VLD ND+ P F    +   V E+VP G 
Sbjct: 1814 DREVEPAFQLRIEARDGGQPAL-SATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGT 1872

Query: 583  PVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVC 642
             ++ +QA D D+G N  + Y        +LG G+AG           F +  SSG +   
Sbjct: 1873 LLLQLQAHDPDAGANGHVTY--------YLGAGTAG----------AFLLEPSSGELRTA 1914

Query: 643  AELDREEVEHYSFGVEAVDHGSP-PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAA 701
            A LDRE+   Y+F V AVD  +  P+S++ SV+ITV DVND+ P F      LRL     
Sbjct: 1915 AALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGP 1974

Query: 702  VGS----SVLTLQARDRD--ANSVITYQLTG----GNTRNRFALSSQRGGGLITLA---L 748
              S    ++ TL+A DRD  AN+ I Y+L G    G T + +        G I +A   +
Sbjct: 1975 SFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYT-------GEIRVARSPV 2027

Query: 749  PLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSI 808
             L  +    +++A       RS T  +++ +       P F  +    ++ E+ P GT I
Sbjct: 2028 ALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI 2087

Query: 809  ATLSANDEDTGENARITYVI--QDPVPQFRIDPDSG--TMYTMMELDYENQVAYTLTIMA 864
             +  A     G N  ITY I   +    F I P +G  T+ +   LD+E      L + A
Sbjct: 2088 VSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQA 2146

Query: 865  QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924
            +  G       T L + + DANDNAP+FL   Y   + E  P    +LQV A D D G  
Sbjct: 2147 ESGG---AFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSG 2203

Query: 925  GRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVE 984
            G++ Y+        G F+++PT+G I T   LDRE  A   L  +A DRGSP  L  S  
Sbjct: 2204 GQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPA-LVGSAT 2262

Query: 985  IQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMR 1044
            + V ++D NDN P   +   EL V E+  +GS +A++  ND D GP   + Y +     +
Sbjct: 2263 LTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQ 2319

Query: 1045 HFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPD- 1103
              F +    G +     LDFE    Y L + A   P   RA + +L+ D NDN P     
Sbjct: 2320 DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQS 2379

Query: 1104 -FQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGEL 1160
             +Q++   +        P   I  + A D D   + + ++   +      +DP  G L
Sbjct: 2380 LYQVMLLEHTP------PGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTL 2431



 Score =  414 bits (1065), Expect = e-115
 Identities = 306/991 (30%), Positives = 492/991 (49%), Gaps = 72/991 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            FP+P Y V + E+ PAGTL+LQL AH    G    V+YY+       + G F ++ ++G 
Sbjct: 1855 FPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGA----GTAGAFLLEPSSGE 1910

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTP-PRSATTYITVLVKDTNDHSPVFEQSEYRERV- 362
            + T + LDRE   ++   V AVD +   P S T  +T+ V+D NDH+P F  S  R R+ 
Sbjct: 1911 LRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLP 1970

Query: 363  RENLEVGYEVL---TIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREE 419
            R         L   T+RA DRD+  NA++ YR+ G       ++  +G +          
Sbjct: 1971 RPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALG 2030

Query: 420  AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVL 479
              +  L + A D GR     SAT  + + ++ E +  P+F   +    + E+    T ++
Sbjct: 2031 PRDRVLFIVATDLGRPAR--SATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIV 2088

Query: 480  RVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP--LDFEDVQKYSLSIKAQ 537
              +A     G N  I YSILSGN  G F +   +G + V +   LDFE   +  L ++A+
Sbjct: 2089 SPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAE 2147

Query: 538  DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597
             GG         V+++ + D NDN P F+   + A + E+ PL  P++ ++A D D G  
Sbjct: 2148 SGGAFAFT----VLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSG 2203

Query: 598  ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGV 657
             ++ Y L  +              PA      F +  ++G IT  A LDRE        +
Sbjct: 2204 GQISYSLAAS-------------QPARGL---FHVDPTTGTITTTAILDREIWAETRLVL 2247

Query: 658  EAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDAN 717
             A D GSP +  S ++++ V+D NDN P   QP +ELR++EDA +GS +  +   D D+ 
Sbjct: 2248 MATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSG 2306

Query: 718  SVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLI 777
             V+ Y L+    ++ F++   R GG ++L  PLD++Q  +Y L + A DG     A++ +
Sbjct: 2307 PVLWYVLSPSGPQDPFSVG--RYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTV 2364

Query: 778  NVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRI 837
             V D N + P F  S Y V + E  P G++I ++SA D D+G N  I+Y +  P   F +
Sbjct: 2365 LVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSV 2424

Query: 838  DPDSGTMYTM---MELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLW 894
            DP++GT++T+   + L ++   A  + + A+D+G P ++   T+ + + D ND+AP F  
Sbjct: 2425 DPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTL 2484

Query: 895  DFYQGSIFEDAPPSTSILQVSATDRD-SGPNGRLLYTFQGGDDGDGDFYIEP-------- 945
              Y+ ++ ED PP +++L + ATD D S  +  + Y+   G+ G   F +EP        
Sbjct: 2485 SHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWG-RVFQLEPRLAEAGES 2543

Query: 946  ------TSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF 999
                    G +     LD E++  YNL   A DRG P P S+ V + VT+LD+NDN P+F
Sbjct: 2544 AGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQP-PQSSVVPVTVTVLDVNDNPPVF 2602

Query: 1000 EKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAM 1059
             +    + V E+ PVG+ +  + A+D D GP+  + + +  GD    F+LD  +G LR  
Sbjct: 2603 TRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLA 2662

Query: 1060 VELDFEVRREYVLVVQAT--SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSN 1117
              LD E +  + LVVQA   +    + A V I + D ND+ P  P      N   T+ + 
Sbjct: 2663 HALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFP-----LNLLSTSVAE 2717

Query: 1118 SFPTG-VIGCIPAHDPDVS--DSLNYTFVQ---GNELR-LLLLDPATGELQLSRDLDNNR 1170
            + P G ++  + A D D      L Y+ ++   G E R    L+ +TGEL+     D   
Sbjct: 2718 NQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEH 2777

Query: 1171 PLEALMEVSVSDGIHSVTAFCTLRVTIITDD 1201
                 + V  +D   +++A  T+ V +  +D
Sbjct: 2778 TESFRLLVGAADA-GNLSASVTVSVLVTGED 2807



 Score =  354 bits (909), Expect = 6e-97
 Identities = 315/1035 (30%), Positives = 477/1035 (46%), Gaps = 87/1035 (8%)

Query: 236  GTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGY 295
            GT G    +F  P Y+V L     AGT +LQ+ A     G    ++Y++     E +   
Sbjct: 992  GTRGLAP-RFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAA---EGASSP 1044

Query: 296  FRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPP---RSATTYITVLVKDTNDHSPV 352
            F ++  +G +   + LDRE +E ++L+V AV  S      ++ T  + V + + N+HSP 
Sbjct: 1045 FGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPR 1104

Query: 353  FEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD--VFQLNESSGVVS 410
              +      V EN   G  V  + A+DRDS  N  L Y +   + D   F+++  +G V+
Sbjct: 1105 LSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVT 1164

Query: 411  TRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYV----- 465
            T   LDRE+ + YQLLV+  D G  P   S T TV++ V D NDN P F + +       
Sbjct: 1165 TLQTLDREQQSSYQLLVQVQDGGSPPR--STTGTVHVAVLDLNDNSPTFLQASGAAGGGL 1222

Query: 466  -VQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDF 524
             +QVP+ V   T V  +QA D D+G+N  I Y+ L+G  +  F LH  SG L    PL  
Sbjct: 1223 PIQVPDRVPPGTLVTTLQAKDPDEGENGTILYT-LTGPGSELFSLHPHSGELLTAAPLIR 1281

Query: 525  EDVQKYSLSIKAQDGGRPPLINSSGVVSVQVL----------DVNDNEPIF-VSSPFQAT 573
             +   Y L++ A D G PP  ++S  + VQVL          D+ + +P   V      T
Sbjct: 1282 AERPHYVLTLSAHDQGSPPR-SASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVT 1340

Query: 574  VLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIH 633
              E +  G  +  + A +  +G  A  +        T +GG           P+  F + 
Sbjct: 1341 AAEGLRPGSLLGSVAAPEP-AGVGALTY--------TLVGGAD---------PEGTFALD 1382

Query: 634  NSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYE 693
             +SG + +   LD E    +       +      +    V + V D N++ P F +    
Sbjct: 1383 AASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLA 1442

Query: 694  LRLNEDAAVGSSVLTLQARDRDA---NSVITYQLTGGNTRNRFALSSQRGGGLITLALPL 750
            L L E+   G+++ T +A D D    NS + Y+L         AL      G ++    L
Sbjct: 1443 LALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVP-ALRLDARTGALSAPRGL 1501

Query: 751  DYKQEQQYVLAVTASD----GTRSHTAHVL--INVTDANTHRPVFQSSHYTVSVSEDRPV 804
            D +     +L V A+D     +R   A V   + VTD N + PVF S    V + ED+P 
Sbjct: 1502 DRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPP 1560

Query: 805  GTSIATLSANDEDTGENARITYVIQDPVP-QFRIDPDSGTMYTMMELDYENQVAYTLTIM 863
            G +   + A D D GE AR++Y +       FR+   +G +  +  LD E +  + LT++
Sbjct: 1561 GPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVV 1620

Query: 864  AQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGP 923
            A D+G P +S T  L + + D ND AP F    Y   + E+ PP TS+L + ATD D G 
Sbjct: 1621 ASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGA 1680

Query: 924  NGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASV 983
            NG++ Y    G      F ++P +GV+ T R LDRE     NL   A DRGSP  L+  V
Sbjct: 1681 NGQVTY----GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLT-HV 1735

Query: 984  EIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDM 1043
             ++V + D ND+AP F    L L V E       +  +RA+DPD G N Q+ Y+I++GD 
Sbjct: 1736 TVRVAVEDENDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRILDGDP 1794

Query: 1044 RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPV 1100
               F LDL +G+   M  LD EV   + L ++A       L +   + + ++D ND+ P 
Sbjct: 1795 SGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPA 1854

Query: 1101 LPDFQILFNNYVTNKSNSFPTGVIGC-IPAHDPDVSDSLNYTFVQG-NELRLLLLDPATG 1158
             P        Y        P G +   + AHDPD   + + T+  G       LL+P++G
Sbjct: 1855 FP-----VPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSG 1909

Query: 1159 ELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDM-------LTNSITVRL 1211
            EL+ +  LD  +       VS  DG  +     T+ VTI   D+        T+ + +RL
Sbjct: 1910 ELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRL 1969

Query: 1212 ENMSQEKFLSPLLAL 1226
                   F +P LAL
Sbjct: 1970 PRPG-PSFSTPTLAL 1983



 Score =  343 bits (880), Expect = 1e-93
 Identities = 303/989 (30%), Positives = 451/989 (45%), Gaps = 70/989 (7%)

Query: 256  ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315
            E +PAGTLI  + A     G    + Y++             ID  +G V T  VLDRE 
Sbjct: 53   EEQPAGTLIGDISAGLPA-GTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQ 111

Query: 316  KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTI 375
            ++ +  R  AV     P  AT  +TV V D NDH+P F Q+    +V E+   G      
Sbjct: 112  RDRY--RFTAVT----PDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLE 165

Query: 376  RASDRDSPINANLRYRVLG-GAWDVFQLNESSGVVST-------RAVLDREEAAEYQLLV 427
             A D D+       Y + G GA + F+L    G   T          LDRE  + Y L +
Sbjct: 166  PARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQL 225

Query: 428  EANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRD 487
            EA D G    P  A A + + + D ND+ P F++  Y   V E +   + VL+V A+D D
Sbjct: 226  EAYDGG--SPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDAD 283

Query: 488  QGQNAAIHYSI--LSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLI 545
             G N A+ Y I        G F + + +G+L +  PLDFE  + + L ++A+DGG  P +
Sbjct: 284  AGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPEL 343

Query: 546  NSSGVVSVQVLDVNDNEP----IFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLH 601
             S+  V+V V D NDN+P    IF+S+     V E  P G  V  I   D D G+ A ++
Sbjct: 344  GSA-FVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVN 402

Query: 602  YRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVD 661
              L      F             T D    +      + V   LDREE + Y+  V A D
Sbjct: 403  VSLEGGEGHF----------ALSTQDSVIYL------VCVARRLDREERDAYNLRVTATD 446

Query: 662  HGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELR-LNEDAAVGSSVLTLQARDRD--ANS 718
             GSPP+ +  +  + V DVNDN P F +  Y    L E A  GS V+ + ARD D   N 
Sbjct: 447  SGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNG 506

Query: 719  VITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHV 775
             +TY L  G   + F++      G+IT A  LDY+ E Q  L V A+DG     + +A V
Sbjct: 507  QVTYSLAPGAHTHWFSIDPT--SGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATV 564

Query: 776  LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI-----QD 830
             + + D N + P FQ + Y  S+ E    GT    ++A D D+G    ++Y +       
Sbjct: 565  SVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSS 624

Query: 831  PVPQFRIDPDSGTMYTMMELDY-ENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
              P FRID  SG + T   LD  +   ++  T+ A D G         +++ + D NDN 
Sbjct: 625  GSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNP 682

Query: 890  PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
            PQF    Y  SI   +PP T++L++ A D D G +GRL Y    G +    F ++  SG+
Sbjct: 683  PQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAG-NSPPLFTLDEQSGL 741

Query: 950  IRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVE 1009
            +     L R   +V  L  +  + G       S  + ++I+      P+FE+ +    V 
Sbjct: 742  LTVAWPLARRANSVVQL-EIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVP 800

Query: 1010 ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE 1069
            E+   G+ V  ++A++P  G  A +   +  GD R  F LD ++G L+ +  LD E+   
Sbjct: 801  EDVAPGTSVGIVQAHNP-PGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGP 859

Query: 1070 YV-LVVQATSA--PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGC 1126
             + L V+A S   P  + A V +LL D NDN P  P  +    + V    N+ P   I  
Sbjct: 860  VLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPE----DTVLLPPNTAPGTPIYT 915

Query: 1127 IPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGI 1184
            + A DPD  V+  + +T + G       +DP TG ++L R L  +      +E+   DG 
Sbjct: 916  LRALDPDSGVNSRVTFTLLAGGG-GAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDG- 973

Query: 1185 HSVTAFCTLRVTIITDDMLTNSITVRLEN 1213
             S       R+ ++  D+ T  +  R  +
Sbjct: 974  GSPPRTSHFRLRVVVQDVGTRGLAPRFNS 1002



 Score =  336 bits (861), Expect = 2e-91
 Identities = 293/966 (30%), Positives = 429/966 (44%), Gaps = 61/966 (6%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F    Y   + E+   G+ +LQ+ A     G    V+Y +     E   G F ID+ TG 
Sbjct: 255  FNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGD-GPFSIDAHTGL 313

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSP----VFEQSEYRE 360
            +  +  LD E +  H L V+A D    P   + ++TV V+D ND+ P    +F  ++   
Sbjct: 314  LQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSP 373

Query: 361  RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAV---LDR 417
            +V E    G  V  I  SD D    A++   + GG    F L+    V+    V   LDR
Sbjct: 374  QVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGH-FALSTQDSVIYLVCVARRLDR 432

Query: 418  EEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL-NT 476
            EE   Y L V A D G    PL A A   + V D NDN P F  Q Y  +   +V L  +
Sbjct: 433  EERDAYNLRVTATDSG--SPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGS 490

Query: 477  AVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKA 536
             V+RV A D DQG N  + YS+  G     F +   SGI+     LD+E   +  L + A
Sbjct: 491  FVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVA 550

Query: 537  QDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE 596
             DGG PPL  SS  VSV + DVNDNEP F  + + A++ E    G   + + A DADSG 
Sbjct: 551  TDGGLPPLA-SSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGP 609

Query: 597  NARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREE-VEHYSF 655
               L Y         LG G     +P      PF+I   SG +     LDR++    + F
Sbjct: 610  FGLLSYS--------LGAGLGSSGSP------PFRIDAHSGDVCTTRTLDRDQGPSSFDF 655

Query: 656  GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
             V AVD G   + S   V + + D NDN P F    Y   ++  +  G++VL L+A D D
Sbjct: 656  TVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPD 713

Query: 716  ANS--VITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRS 770
              S   ++Y +  GN+   F L  Q   GL+T+A PL  +      L + A DG      
Sbjct: 714  QGSHGRLSYHILAGNSPPLFTLDEQ--SGLLTVAWPLARRANSVVQLEIGAEDGGGLQAE 771

Query: 771  HTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ- 829
             +A V I++       P+F+   Y  SV ED   GTS+  + A++   G  A +T  +  
Sbjct: 772  PSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHN-PPGRLAPVTLSLSG 830

Query: 830  -DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDN 888
             DP   F +D  SG + T+  LD E         +   +G+P       + +L+ D NDN
Sbjct: 831  GDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDN 890

Query: 889  APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG 948
            +P F        +  +  P T I  + A D DSG N R+ +T   G  G G F ++PT+G
Sbjct: 891  SPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAG--GGGAFTVDPTTG 948

Query: 949  VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDN--APMFEKDELEL 1006
             +R  R L       + L   A D GSP P ++   ++V + D+     AP F      +
Sbjct: 949  HVRLMRPLGPSGGPAHELELEARDGGSP-PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV 1007

Query: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV 1066
             +      G+ V +++A  PD GP   I Y +        F L+  +G L     LD E 
Sbjct: 1008 DLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREA 1064

Query: 1067 RREYVLVVQATS------APLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFP 1120
            +  Y+L V A S            ATV + +++QN++ P L +       ++    N  P
Sbjct: 1065 QELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDP----TFLAVAENQPP 1120

Query: 1121 TGVIGCIPAHDPDVSDS--LNYTFVQ-GNELRLLLLDPATGELQLSRDLDNNRPLEALME 1177
               +G + A D D   +  L Y+  Q   + +   + P TGE+   + LD  +     + 
Sbjct: 1121 GTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLL 1180

Query: 1178 VSVSDG 1183
            V V DG
Sbjct: 1181 VQVQDG 1186



 Score =  326 bits (835), Expect = 2e-88
 Identities = 282/927 (30%), Positives = 417/927 (44%), Gaps = 57/927 (6%)

Query: 294  GYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVF 353
            G F +D+A+G +     LD E            +      +    + V V+D N+H+P F
Sbjct: 1377 GTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAF 1436

Query: 354  EQSEYRERVRENLEVGYEVLTIRASDRDSP-INANLRYRVLGGAWDV--FQLNESSGVVS 410
             +      + EN E G  + T RASD D P  N+++RYR+L     V   +L+  +G +S
Sbjct: 1437 ARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALS 1496

Query: 411  TRAVLDREEAAEYQLLVEANDQGRNPG-PLSATATVYIEVEDENDNYPQFSEQNYVVQVP 469
                LDRE      LLVEA D+  N     +A  +  + V DENDN P F+  +  V++P
Sbjct: 1497 APRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSR-VRLP 1555

Query: 470  EDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQK 529
            ED     A L V A D D G+ A + Y + SG   G F LHS +G L V+ PLD E   +
Sbjct: 1556 EDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGALSVVRPLDREQRAE 1614

Query: 530  YSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQA 589
            + L++ A D G PP  +++ V++V V DVND  P F    +   + EN P G  ++ ++A
Sbjct: 1615 HVLTVVASDHGSPPR-SATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRA 1673

Query: 590  VDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREE 649
             D D G N ++ Y  V + S                    F +   +G +T    LDREE
Sbjct: 1674 TDPDVGANGQVTYGGVSSES--------------------FSLDPDTGVLTTLRALDREE 1713

Query: 650  VEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTL 709
             E  +  V A D GSPP  +  +V + V D ND+ P F      L + E      ++  L
Sbjct: 1714 QEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPE-GQDPQTLTML 1772

Query: 710  QARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG 767
            +A D D  AN  + Y++  G+    F L      G      PLD + E  + L + A DG
Sbjct: 1773 RASDPDVGANGQLQYRILDGDPSGAFVL--DLASGEFGTMRPLDREVEPAFQLRIEARDG 1830

Query: 768  TR---SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARI 824
             +   S T  + + V DAN H P F    Y+V V ED P GT +  L A+D D G N  +
Sbjct: 1831 GQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHV 1890

Query: 825  TYVI-QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP-QKSDTTTLEILI 882
            TY +       F ++P SG + T   LD E   +YT ++ A D       S T ++ I +
Sbjct: 1891 TYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITV 1950

Query: 883  LDANDNAPQFLWDFYQGSIFEDAP----PSTSILQVSATDRDSGPNGRLLYTFQGGDDGD 938
             D ND+AP F     +  +    P    P+ ++  + A DRD+G N  +LY   G     
Sbjct: 1951 RDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPG 2010

Query: 939  GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPM 998
                ++  +G IR  R           L+ +A D G P   SA+  I V +    +  P 
Sbjct: 2011 TT--VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPA-RSATGVIIVGLQGEAERGPR 2067

Query: 999  FEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNG--DL 1056
            F +   E  + EN P G+ +   RA     G N  I Y I+ G+ +  F +    G   +
Sbjct: 2068 FPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITV 2126

Query: 1057 RAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKS 1116
            R+   LDFEV     LV+QA S    +   + + L D NDN P     + L  +YV    
Sbjct: 2127 RSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAP-----RFLRPHYVAFLP 2181

Query: 1117 NSFP-TGVIGCIPAHDPDVSD--SLNYTFVQGNELR-LLLLDPATGELQLSRDLDNNRPL 1172
             S P  G +  + A D D      ++Y+       R L  +DP TG +  +  LD     
Sbjct: 2182 ESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWA 2241

Query: 1173 EALMEVSVSD-GIHSVTAFCTLRVTII 1198
            E  + +  +D G  ++    TL V +I
Sbjct: 2242 ETRLVLMATDRGSPALVGSATLTVMVI 2268



 Score =  323 bits (829), Expect = 1e-87
 Identities = 287/963 (29%), Positives = 427/963 (44%), Gaps = 80/963 (8%)

Query: 248  PNYQVALFENEPA------GTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
            P +   L+  EP       G+ ++++ A    +G   +V+Y    L       +F ID  
Sbjct: 470  PAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTY---SLAPGAHTHWFSIDPT 526

Query: 302  TGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRER 361
            +G ++T + LD E +    L V A D   PP +++  ++V ++D ND+ P F+++ Y   
Sbjct: 527  SGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNAS 586

Query: 362  VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV----FQLNESSGVVSTRAVLDR 417
            + E  + G   L + A+D DS     L Y +  G        F+++  SG V T   LDR
Sbjct: 587  LPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDR 646

Query: 418  EEA-AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNT 476
            ++  + +   V A D G     L +   V + + DENDN PQF  + Y   +       T
Sbjct: 647  DQGPSSFDFTVTAVDGGG----LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGT 702

Query: 477  AVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKA 536
            AVLR++A D DQG +  + Y IL+GN    F L   SG+L V  PL         L I A
Sbjct: 703  AVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGA 762

Query: 537  QDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE 596
            +DGG       S  V + ++      PIF    +  +V E+V  G  V  +QA +     
Sbjct: 763  EDGGGLQA-EPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPG-- 819

Query: 597  NARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFG 656
                  RL     +  GG   G           F +   SG +     LDRE +      
Sbjct: 820  ------RLAPVTLSLSGGDPRGL----------FSLDAVSGLLQTLRPLDRELLGPVLEL 863

Query: 657  VEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA 716
                  G PP  +   V + + DVNDN P F  P   + L  + A G+ + TL+A D D+
Sbjct: 864  EVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDS 923

Query: 717  --NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG-TRSHTA 773
              NS +T+ L  G      A +     G + L  PL       + L + A DG +   T+
Sbjct: 924  GVNSRVTFTLLAGGGG---AFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTS 980

Query: 774  HVLINVT--DANTH--RPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI- 828
            H  + V   D  T    P F S  Y V +      GT +  + A   D G    ITY + 
Sbjct: 981  HFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLA 1037

Query: 829  -QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNG---IPQKSDTTTLEILILD 884
             +     F ++P SG ++    LD E Q  Y L +MA       + Q++ T T+ + IL+
Sbjct: 1038 AEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILN 1097

Query: 885  ANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIE 944
             N+++P+   D    ++ E+ PP TS+ +V ATDRDSGPNGRL Y+ Q   +    F I 
Sbjct: 1098 QNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIH 1157

Query: 945  PTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDE- 1003
            P +G + T + LDRE  + Y L     D GSP P S +  + V +LD+NDN+P F +   
Sbjct: 1158 PQTGEVTTLQTLDREQQSSYQLLVQVQDGGSP-PRSTTGTVHVAVLDLNDNSPTFLQASG 1216

Query: 1004 -----LELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRA 1058
                 L + V +  P G++V  ++A DPDEG N  I+Y +  G     F L   +G+L  
Sbjct: 1217 AAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT-GPGSELFSLHPHSGELLT 1275

Query: 1059 MVELDFEVRREYVLVVQATSAPLVSRATVHILLV-------------DQNDNPPVLPDFQ 1105
               L    R  YVL + A       R+    LLV             D  +  P  P   
Sbjct: 1276 AAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPV 1335

Query: 1106 ILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELR-LLLLDPATGELQLSR 1164
            +L    VT      P  ++G + A +P    +L YT V G +      LD A+G L L+R
Sbjct: 1336 VL---TVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLAR 1392

Query: 1165 DLD 1167
             LD
Sbjct: 1393 PLD 1395



 Score =  318 bits (815), Expect = 5e-86
 Identities = 288/977 (29%), Positives = 431/977 (44%), Gaps = 74/977 (7%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +F    Y  +L E    GT  LQ+ A     G    +SY +           FRID+ +G
Sbjct: 577  QFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSG 636

Query: 304  AVSTDSVLDRET-KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
             V T   LDR+    +    V AVD       +  Y+ V + D ND+ P F   EY   +
Sbjct: 637  DVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKVFLSDENDNPPQFYPREYAASI 694

Query: 363  RENLEVGYEVLTIRASDRDSPINANLRYRVL-GGAWDVFQLNESSGVVSTRAVLDREEAA 421
                  G  VL +RA D D   +  L Y +L G +  +F L+E SG+++    L R   +
Sbjct: 695  SAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANS 754

Query: 422  EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRV 481
              QL + A D G        +A V I +       P F +  YV  VPEDV   T+V  V
Sbjct: 755  VVQLEIGAEDGGGLQA--EPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIV 812

Query: 482  QATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGR 541
            QA     G+ A +  S+  G+  G F L ++SG+L  + PLD E +    L ++ + G  
Sbjct: 813  QA-HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPV-LELEVRAGSG 870

Query: 542  PPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLH 601
             P   +   V V + DVNDN P F +      +  N   G P+  ++A+D DSG N+R+ 
Sbjct: 871  VPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVT 930

Query: 602  YRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVD 661
            + L+       GGG A            F +  ++G + +   L       +   +EA D
Sbjct: 931  FTLL------AGGGGA------------FTVDPTTGHVRLMRPLGPSGGPAHELELEARD 972

Query: 662  HGSPPMSSSTSVSITVLDVNDND--PVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSV 719
             GSPP +S   + + V DV      P F  PTY + L      G+ VL +QA+  D    
Sbjct: 973  GGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP- 1031

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSH------TA 773
            ITY L      + F L  Q   G + +   LD + ++ Y+L V A  G+++       TA
Sbjct: 1032 ITYHLAAEGASSPFGLEPQ--SGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTA 1089

Query: 774  HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ---D 830
             V +++ + N H P        ++V+E++P GTS+  + A D D+G N R+TY +Q   +
Sbjct: 1090 TVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSE 1149

Query: 831  PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAP 890
                FRI P +G + T+  LD E Q +Y L +  QD G P +S T T+ + +LD NDN+P
Sbjct: 1150 DSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSP 1209

Query: 891  QFLWDFYQG------SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIE 944
             FL             + +  PP T +  + A D D G NG +LYT  G   G   F + 
Sbjct: 1210 TFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTG--PGSELFSLH 1267

Query: 945  PTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILD---INDNAP-MFE 1000
            P SG + T   L R     Y L   A D+GSP P SAS+++ V +L    + +  P + E
Sbjct: 1268 PHSGELLTAAPLIRAERPHYVLTLSAHDQGSP-PRSASLQLLVQVLPSARLAEPPPDLAE 1326

Query: 1001 KDE-------LELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEG-DMRHFFQLDLL 1052
            +D        L +   E    GS++  + A +P  G  A + Y +V G D    F LD  
Sbjct: 1327 RDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEP-AGVGA-LTYTLVGGADPEGTFALDAA 1384

Query: 1053 NGDLRAMVELDFEVRREYVLVVQATSAPLVSRA---TVHILLVDQNDNPPVLPDFQILFN 1109
            +G L     LDFE    +  +      P  + A    V + + D+N++ P      +   
Sbjct: 1385 SGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLA-- 1442

Query: 1110 NYVTNKSNSFPTGVIGCIPAHD---PDVSDSLNYTFV-QGNELRLLLLDPATGELQLSRD 1165
              +    N  P   +    A D   P  +  + Y  + Q   +  L LD  TG L   R 
Sbjct: 1443 --LALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRG 1500

Query: 1166 LDNNRPLEALMEVSVSD 1182
            LD       L+ V  +D
Sbjct: 1501 LDRETTPALLLLVEATD 1517



 Score =  308 bits (789), Expect = 5e-83
 Identities = 247/860 (28%), Positives = 396/860 (46%), Gaps = 78/860 (9%)

Query: 235  RGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRG 294
            +G + RG  +FP  + +  + EN P GT I+   A +   G    ++Y    +     +G
Sbjct: 2059 QGEAERGP-RFPRASSEATIRENAPPGTPIVSPRAVHA-GGTNGPITY---SILSGNEKG 2113

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
             F I  +TGA++  S    + + +  LR+  +   +    A T +T+ ++D ND++P F 
Sbjct: 2114 TFSIQPSTGAITVRSAEGLDFEVSPRLRL-VLQAESGGAFAFTVLTLTLQDANDNAPRFL 2172

Query: 355  QSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG--AWDVFQLNESSGVVSTR 412
            +  Y   + E+  +   +L + A D D      + Y +     A  +F ++ ++G ++T 
Sbjct: 2173 RPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTT 2232

Query: 413  AVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDV 472
            A+LDRE  AE +L++ A D+G +P  L  +AT+ + V D NDN P    Q + ++V ED 
Sbjct: 2233 AILDREIWAETRLVLMATDRG-SPA-LVGSATLTVMVIDTNDNRPTIP-QPWELRVSEDA 2289

Query: 473  GLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSL 532
             L + + +V   D D G    + Y +        F +    G + +  PLDFE   +Y L
Sbjct: 2290 LLGSEIAQVTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQL 2347

Query: 533  SIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDA 592
             + A DG      N    ++V V DVNDN P F  S +Q  +LE+ P G  ++ + A D 
Sbjct: 2348 QLLAHDGPHEGRAN----LTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDR 2403

Query: 593  DSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQI-------HNSSGWITVCAEL 645
            DSG N  + Y L   A  F    S  P N        F I       H+ SG + V    
Sbjct: 2404 DSGANGHISYHLASPADGF----SVDPNNGTL-----FTIVGTVALGHDGSGAVDVV--- 2451

Query: 646  DREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSS 705
                       +EA DHG+P  ++  +V + + D ND+ P FT   Y + + ED   GS+
Sbjct: 2452 -----------LEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGST 2500

Query: 706  VLTLQARDRD---ANSVITYQLTGGNTRNRFALSSQ------------RGGGLITLALPL 750
            +LTL+A D D   +++ + Y +  GN    F L  +            R  G + L  PL
Sbjct: 2501 LLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPL 2560

Query: 751  DYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTS 807
            D++   QY L V A+D     +S    V + V D N + PVF  + Y V+V ED PVG  
Sbjct: 2561 DFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAE 2620

Query: 808  IATLSANDEDTGENARITYVIQ--DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQ 865
            +  + A+D D G +  + + +   DP   F +D  SGT+     LD E Q  + L + A 
Sbjct: 2621 LLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAA 2680

Query: 866  DN-GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924
            D  G        T+E+   D ND+ P F  +    S+ E+ PP T +  + A D D+G  
Sbjct: 2681 DPAGAHFALAPVTIEVQ--DVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAF 2738

Query: 925  GRLLYTFQG---GDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981
            GRL Y+      G +G   F +  ++G +R +   D E+   + L   A D G+   LSA
Sbjct: 2739 GRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN---LSA 2795

Query: 982  SVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEG 1041
            SV + V +   ++  P+F        V E    G  +  ++A D D G +  ++Y +   
Sbjct: 2796 SVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATS 2855

Query: 1042 DMRHFFQLDLLNGDLRAMVE 1061
                +F ++   G L   V+
Sbjct: 2856 S--PYFGINQTTGALYLRVD 2873



 Score =  300 bits (769), Expect = 1e-80
 Identities = 267/919 (29%), Positives = 406/919 (44%), Gaps = 60/919 (6%)

Query: 311  LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370
            LDRE +  ++L+++A D  +PPR A   + V + D NDH+P F QS Y   V E+L  G 
Sbjct: 213  LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGS 272

Query: 371  EVLTIRASDRDSPINANLRYRV---LGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLV 427
             VL + ASD D+ +N  + Y +          F ++  +G++     LD E+   ++L+V
Sbjct: 273  PVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVV 332

Query: 428  EANDQGRNPGPLSATATVYIEVEDENDNYPQ----FSEQNYVVQVPEDVGLNTAVLRVQA 483
            +A D G +P   SA  TV+  V D NDN P     F   +   QV E       V R+  
Sbjct: 333  QARDGGAHPELGSAFVTVH--VRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISV 390

Query: 484  TDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVI---NPLDFEDVQKYSLSIKAQDGG 540
            +D D G  A ++ S+  G   G F L +   ++ ++     LD E+   Y+L + A D G
Sbjct: 391  SDPDDGDFAHVNVSLEGGE--GHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSG 448

Query: 541  RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPL-GYPVVHIQAVDADSGENAR 599
             PPL   +  V + V DVNDN P F    ++   L  V L G  VV + A D D G N +
Sbjct: 449  SPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQ 507

Query: 600  LHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEA 659
            + Y L   A T                   F I  +SG IT  A LD E        V A
Sbjct: 508  VTYSLAPGAHTHW-----------------FSIDPTSGIITTAASLDYELEPQPQLIVVA 550

Query: 660  VDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDAN-- 717
             D G PP++SS +VS+ + DVNDN+P F +  Y   L E    G+  L + A D D+   
Sbjct: 551  TDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPF 610

Query: 718  SVITYQL---TGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTA 773
             +++Y L    G +    F + +  G    T  L  D +    +   VTA D G      
Sbjct: 611  GLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRD-QGPSSFDFTVTAVDGGGLKSMV 669

Query: 774  HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI--QDP 831
            +V + ++D N + P F    Y  S+S   P GT++  L A+D D G + R++Y I   + 
Sbjct: 670  YVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNS 729

Query: 832  VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891
             P F +D  SG +     L         L I A+D G  Q   +  ++I I+      P 
Sbjct: 730  PPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPI 789

Query: 892  FLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRL--LYTFQGGDDGDGDFYIEPTSGV 949
            F    Y  S+ ED  P TS+  V A      P GRL  +     G D  G F ++  SG+
Sbjct: 790  FEQLQYVFSVPEDVAPGTSVGIVQA----HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGL 845

Query: 950  IRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVE 1009
            ++T R LDRE +       +    G P P  A   ++V + D+NDN+P F   E  + + 
Sbjct: 846  LQTLRPLDRELLGPVLELEVRAGSGVP-PAFAVARVRVLLDDVNDNSPAFPAPEDTVLLP 904

Query: 1010 ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE 1069
             N   G+ +  +RA DPD G N+++ + ++ G     F +D   G +R M  L       
Sbjct: 905  PNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPA 963

Query: 1070 YVLVVQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGC 1126
            + L ++A    S P  S   + +++ D      + P F             +  T V+  
Sbjct: 964  HELELEARDGGSPPRTSHFRLRVVVQDVGTR-GLAPRFNSPTYRVDLPSGTTAGTQVLQ- 1021

Query: 1127 IPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDG--- 1183
            + A  PD    + Y            L+P +G L +   LD       +++V    G   
Sbjct: 1022 VQAQAPD-GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKA 1080

Query: 1184 -IHSVTAFCTLRVTIITDD 1201
             +   T   T+RV+I+  +
Sbjct: 1081 ELGQQTGTATVRVSILNQN 1099



 Score =  297 bits (760), Expect = 1e-79
 Identities = 245/795 (30%), Positives = 372/795 (46%), Gaps = 80/795 (10%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +F  P+Y   L E+ P    +LQ+ A    +G   ++SY +     + +RG F +D  TG
Sbjct: 2170 RFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAA--SQPARGLFHVDPTTG 2227

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
             ++T ++LDRE      L + A D  +P    +  +TV+V DTND+ P   Q  +  RV 
Sbjct: 2228 TITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVS 2286

Query: 364  ENLEVGYEVLTIRASDRDSPINANLRYRVLG--GAWDVFQLNESSGVVSTRAVLDREEAA 421
            E+  +G E+  +  +D DS     + + VL   G  D F +    G VS    LD E+  
Sbjct: 2287 EDALLGSEIAQVTGNDVDS---GPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCD 2343

Query: 422  EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRV 481
             YQL + A+D     GP    A + + VED NDN P FS+  Y V + E     +A+L V
Sbjct: 2344 RYQLQLLAHD-----GPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSV 2398

Query: 482  QATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN---PLDFEDVQKYSLSIKAQD 538
             ATDRD G N  I Y + S   A  F +   +G L  I     L  +      + ++A+D
Sbjct: 2399 SATDRDSGANGHISYHLASP--ADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD 2456

Query: 539  GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDAD-SGEN 597
             G P    +   V VQ+ D ND+ P F  S ++  V E++P G  ++ ++A DAD S  +
Sbjct: 2457 HGAPGRA-ARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSH 2515

Query: 598  ARLHYRLVD---------TASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE 648
            A + Y ++                 G SAGP   A             G + +   LD E
Sbjct: 2516 AAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRA------------LGCLVLLEPLDFE 2563

Query: 649  EVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708
             +  Y+  V A D G PP SS   V++TVLDVNDN PVFT+ +Y + + ED  VG+ +L 
Sbjct: 2564 SLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLH 2623

Query: 709  LQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
            ++A D D   + ++ + ++ G+    F L      G + LA  LD + + ++ L V A+D
Sbjct: 2624 VEASDADPGPHGLVRFTVSSGDPSGLFELDES--SGTLRLAHALDCETQARHQLVVQAAD 2681

Query: 767  GTRSH--TAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARI 824
               +H   A V I V D N H P F  +  + SV+E++P GT + TL A D D G   R+
Sbjct: 2682 PAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRL 2741

Query: 825  TYVIQDPVP------QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTL 878
             Y + +  P       F ++  +G +   +  DYE+  ++ L + A D G    S + T+
Sbjct: 2742 RYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAG--NLSASVTV 2799

Query: 879  EILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYT------FQ 932
             +L+   ++  P FL   +   + E A    S+  V ATD D G +G +LY+      + 
Sbjct: 2800 SVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYF 2859

Query: 933  GGDDGDGDFYIE-----PTSGVI------RTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981
            G +   G  Y+      P SG        RT+R   RE         L V    P P S 
Sbjct: 2860 GINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRE-------LRLEVIARGPLPGSR 2912

Query: 982  SVEIQVTILDINDNA 996
            S  + VT+ DI   A
Sbjct: 2913 SATVPVTV-DITHTA 2926


>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
          Length = 3354

 Score =  413 bits (1062), Expect = e-114
 Identities = 329/1008 (32%), Positives = 496/1008 (49%), Gaps = 67/1008 (6%)

Query: 254  LFENEPAGTLILQLHAHYTIEGEEERVSYYME-GLFDERSRGYFRIDSATGAVSTDSVLD 312
            + E  PAG  I Q+ A    EG    VSY M  G+     R  F I+S++G V T + LD
Sbjct: 899  VLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM----PRMDFLINSSSGVVVTTTELD 954

Query: 313  RETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEV 372
            RE    + LRV A D  TP +S+T+ +T+ V D ND +P F  + Y   V E++   + V
Sbjct: 955  RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014

Query: 373  LTIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEYQLLVEAND 431
            + +  +D D  +NA L Y + GG  D  F +     VV T   LDRE  A Y L++EA D
Sbjct: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAID 1074

Query: 432  QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
             G      + TATV++ V D NDN P F + +Y   VPED+    ++L+++ATD D+G+ 
Sbjct: 1075 NGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF 1134

Query: 492  AAIHYSILSGNVAGQFYLHSLSGIL-DVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGV 550
              + Y IL GN    F +H  +G+L     PLD E    + L ++A +    P+ +S  V
Sbjct: 1135 GRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRV 1194

Query: 551  VSVQVLDVNDNEPIFVSSPFQATVL-ENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
            + V V D+ND  P+F    +    L E   +G  V+ +QA D DSG+   ++YR++  A 
Sbjct: 1195 I-VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGA- 1252

Query: 610  TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
                             +  F+I  S+G I     LD E    Y   V A D   P    
Sbjct: 1253 -----------------EGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQG 1295

Query: 670  STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTG-GN 728
              SV IT+L+  D    F+  +YE  + E+ A+G+ ++ +QA   D  + ITY+     +
Sbjct: 1296 FCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTS 1355

Query: 729  TRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG--TRSHTAHVLINVTDANTHR 786
            T+ +         G+IT+   +D ++   Y L V A DG      T  V I V D N + 
Sbjct: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNS 1415

Query: 787  PVFQ-SSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQFRI---DPD 840
            P F  +S   VS+ ED PVG  +AT+ A D D G N ++ + +   +    F I   +  
Sbjct: 1416 PRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDS 1475

Query: 841  SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDF-YQG 899
             G ++    LD E    Y L ++A D G P +     L++ ILD NDN P     F Y  
Sbjct: 1476 IGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNV 1535

Query: 900  SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ-RRLDR 958
            S+ E+    T+++QV ATDRD G N  L Y    G+  D  F ++  SG I T+    DR
Sbjct: 1536 SVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNK-DMAFRMDRISGEIATRPAPPDR 1594

Query: 959  ENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEEN-NPVGSV 1017
            E  + Y+L A   D G+PT LSA+  + VTI+D NDNAPMF++   E+ ++E  + + + 
Sbjct: 1595 ERQSFYHLVATVEDEGTPT-LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTS 1653

Query: 1018 VAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRR-EYVLVVQA 1076
            +  I+A D DEGPN  + Y IV G++ + F++D   G + A  ELD+E+    Y L+V A
Sbjct: 1654 LITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTA 1713

Query: 1077 T------SAPLVSRATVHILLVDQNDNPPVLP-DFQILFNNYVTNKSNSFPTGVIGCIPA 1129
            T      S  L S  TV + + D NDN P  P D++  F       +   P   +    A
Sbjct: 1714 TDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPF-----EVTEGQPGPRVWTFLA 1768

Query: 1130 HDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIH-- 1185
            HD D   +  + Y+ + G+ L   ++ P  G L++ +D++ +R   A   +++       
Sbjct: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828

Query: 1186 ---SVTAFCTLRVTIITDD-----MLTNSITVRLENMSQEKFLSPLLA 1225
               S T    +RV  I D+      L  +IT+  EN     F++ +LA
Sbjct: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITIS-ENSPVSSFVAHVLA 1875



 Score =  399 bits (1024), Expect = e-110
 Identities = 293/915 (32%), Positives = 458/915 (50%), Gaps = 89/915 (9%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHY-TIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            F    YQ  + EN PAGT +  L+     ++ +++  +     L   +S G F I+S+TG
Sbjct: 1959 FTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS-GLFDINSSTG 2017

Query: 304  AVSTDS--VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRER 361
             V+  S  ++DRE     +L +  +       ++T ++ + + D ND+ P F  +     
Sbjct: 2018 VVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVH 2077

Query: 362  VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVST-RAVLDREEA 420
            + EN   G+ VL + A+D DS +N  L YR+  GA D F ++  +GV+    A +DREE 
Sbjct: 2078 LLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQ 2137

Query: 421  AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480
              Y+L V A D+G  P  LS TA V I ++D ND+ P+F      V V E     T +  
Sbjct: 2138 ESYRLTVVATDRGTVP--LSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN 2195

Query: 481  VQATDRDQGQNAAIHYSI-----------LSGNVAGQFYLHSLSGILDVINPLDFEDVQK 529
            + A D D   N  + Y I           L  N    F ++  +G + V +P++ E V  
Sbjct: 2196 ITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVAT 2253

Query: 530  YSLSIKAQDGGRPPLINSSGV----VSVQVLDVNDNEPIFVSSPFQAT-----VLENVPL 580
            Y +++   D        S  V    ++V VLDVNDN P F   PF  T     +LE    
Sbjct: 2254 YEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF--KPFGITYYMERILEGATP 2311

Query: 581  GYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWIT 640
            G  ++ + AVD D G N  + Y L+D                   P +     +S+G + 
Sbjct: 2312 GTTLIAVAAVDPDKGLNGLVTYTLLDLVP----------------PGYVQLEDSSAGKVI 2355

Query: 641  VCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDA 700
                +D EEV   +F V A D+GSPP ++   V + ++D+NDN+P+F QP+Y+  + ED 
Sbjct: 2356 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415

Query: 701  AVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVL 760
             VG+ +LT+ A D D+ +    + + G+  ++FA++   G   I +   LD +++  Y+L
Sbjct: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGD--IYVLSSLDREKKDHYIL 2473

Query: 761  AVTASD-------GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
               A D         R ++  V+I V D N  RP F    ++ SV E+ P GTS+ T+ A
Sbjct: 2474 TALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMA 2533

Query: 814  NDEDTGENARITYVIQDP-VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK 872
             D+D G N  +TY ++ P V  F +D DSG + T   L  ++   ++LT++A D G P  
Sbjct: 2534 TDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPL 2591

Query: 873  SDTTTLEILILDANDNAPQFLWDFYQGSIF---EDAPPSTSILQVSATDRDSGPNGRLLY 929
              TT L + ++D NDN P F+     G+I    E+ P  +++ +V ATD+D G NG + Y
Sbjct: 2592 WGTTMLLVEVIDVNDNRPVFVRP-PNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRY 2650

Query: 930  TF-QGGDDGDGDFY-IEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQV 987
            +F +   + D +F+ I+P SG+I+T +RLDRE+ AVY+L  +A D G P P      +QV
Sbjct: 2651 SFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQV 2710

Query: 988  TILDINDNAPMFEKDELE------LFVEENNPVGSVVAKIR-ANDPDEGPNAQIMYQIVE 1040
             + DI+DN P+F +          L V E++P G++V  +  A D DEGPNA + Y I  
Sbjct: 2711 ALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAA 2770

Query: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATS-------------APLVSRAT- 1086
            G+    F L   +G L  + +LD E    +  +V+A+S               LV+  T 
Sbjct: 2771 GNEEKNFHLQ-PDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTL 2829

Query: 1087 --VHILLVDQNDNPP 1099
              V ++L D ND PP
Sbjct: 2830 QEVRVVLEDINDQPP 2844



 Score =  387 bits (993), Expect = e-106
 Identities = 298/994 (29%), Positives = 487/994 (48%), Gaps = 73/994 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHA---HYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
            F  P Y V++ EN  AG  +L L+A     + E  +E + Y +EG         FRI++ 
Sbjct: 671  FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ------FRINAR 724

Query: 302  TGAVSTDSVLDRETKETHVLRVKAVD----YSTPPRSATTYITVLVKDTNDHSPVFEQSE 357
            +G ++T S+LDRETK  ++L V+AVD    ++     AT  IT+L  D ND+ P ++ + 
Sbjct: 725  SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLL--DINDNHPTWKDAP 782

Query: 358  YRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVV-STRAVLD 416
            Y   + E      +V T+ A D D   N  L Y +       + LN ++G + +T A+LD
Sbjct: 783  YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-KFYSLNSTTGKIRTTHAMLD 841

Query: 417  REEAAEYQ------LLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPE 470
            RE    ++      ++V   D GR P   +++ATV++ + D NDN P F    +V +V E
Sbjct: 842  RENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 901

Query: 471  DVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKY 530
             +    ++ +V A D D+G N  + Y +  G     F ++S SG++     LD E + +Y
Sbjct: 902  GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEY 961

Query: 531  SLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAV 590
             L + A D G P   +S+  +++ VLDVND  P F  + +  +V E+VP  + VV +   
Sbjct: 962  QLRVVASDAGTPTK-SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT 1020

Query: 591  DADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEV 650
            D D G NA L Y        F+ GG+          D  F +      +     LDRE  
Sbjct: 1021 DNDVGLNAELSY--------FITGGNV---------DGKFSVGYRDAVVRTVVGLDRETT 1063

Query: 651  EHYSFGVEAVDHG--SPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708
              Y   +EA+D+G      + + +V +TVLDVNDN P+F Q +YE  + ED   G S+L 
Sbjct: 1064 AAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQ 1123

Query: 709  LQARDRDANSV--ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
            L+A D D      + Y++  GN  N F +     G L+    PLD ++   +VL V A +
Sbjct: 1124 LKATDADEGEFGRVWYRILHGNHGNNFRIHVS-NGLLMRGPRPLDRERNSSHVLIVEAYN 1182

Query: 767  ---GTRSHTAHVLINVTDANTHRPVFQSSHYT-VSVSEDRPVGTSIATLSANDEDTGENA 822
               G    +  V++ V D N   PVF    Y+ + + E   +GTS+  + A D D+G+  
Sbjct: 1183 HDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGG 1242

Query: 823  RITY-VIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEIL 881
             + Y ++     +F ID  +G + T+  LDYE + +Y + + A D   P      ++ I 
Sbjct: 1243 LVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYIT 1302

Query: 882  ILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQG--GDDGDG 939
            +L+  D A QF    Y+ +I E+    T I++V A   D+    ++ Y F          
Sbjct: 1303 LLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKA 1360

Query: 940  DFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF 999
             F I+  +GVI  Q  +DRE    Y L  +A D G    + ++V++ +T+LD NDN+P F
Sbjct: 1361 LFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG--PKVDSTVKVYITVLDENDNSPRF 1418

Query: 1000 E-KDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLN---GD 1055
            +   +  + + E+ PVG  VA ++A DPD G N Q+++ +  G++   F++   N   G+
Sbjct: 1419 DFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGE 1478

Query: 1056 LRAMVELDFEVRREYVLVVQATSAPLVSRATVHIL---LVDQNDNPPVLPDFQILFNNYV 1112
            +     LD E    Y+L V A+      R   HIL   ++D NDNPPV+   +  F   V
Sbjct: 1479 VFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVI---ESPFGYNV 1535

Query: 1113 TNKSNSFPTGVIGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNR 1170
            +   N      +  + A D D  ++  L+Y   +GN+     +D  +GE+  +R    +R
Sbjct: 1536 SVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEI-ATRPAPPDR 1594

Query: 1171 PLEA---LMEVSVSDGIHSVTAFCTLRVTIITDD 1201
              ++   L+     +G  +++A   + VTI+ ++
Sbjct: 1595 ERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEN 1628



 Score =  380 bits (976), Expect = e-104
 Identities = 310/963 (32%), Positives = 474/963 (49%), Gaps = 62/963 (6%)

Query: 250  YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDS 309
            Y V++ E+ P    ++ L+      G    +SY++ G       G F +      V T  
Sbjct: 1000 YNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG---GNVDGKFSVGYRDAVVRTVV 1056

Query: 310  VLDRETKETHVLRVKAVDYSTPPR----SATTYITVLVKDTNDHSPVFEQSEYRERVREN 365
             LDRET   ++L ++A+D     +    +AT ++TVL  D ND+ P+F QS Y   V E+
Sbjct: 1057 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL--DVNDNRPIFLQSSYEASVPED 1114

Query: 366  LEVGYEVLTIRASDRDSPINANLRYRVL-GGAWDVFQLNESSGVVSTRA-VLDREEAAEY 423
            +  G+ +L ++A+D D      + YR+L G   + F+++ S+G++      LDRE  + +
Sbjct: 1115 IPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSH 1174

Query: 424  QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYV-VQVPEDVGLNTAVLRVQ 482
             L+VEA +   + GP+ ++  V + VED ND  P F++Q Y  + + E  G+ T+V+ VQ
Sbjct: 1175 VLIVEAYNH--DLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQ 1232

Query: 483  ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP 542
            ATDRD G    ++Y ILSG   G+F +   +G++  +N LD+E    Y +++ A D   P
Sbjct: 1233 ATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQA-P 1290

Query: 543  PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHY 602
            P       V + +L+  D    F ++ ++A +LEN+ LG  +V +QA   D+    ++ Y
Sbjct: 1291 PFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN--QITY 1348

Query: 603  RLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDH 662
            R     ST                   F+I   +G ITV   +DRE+ + Y+  V A D 
Sbjct: 1349 RFNAYTST--------------QAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DD 1393

Query: 663  GSPPMSSSTSVSITVLDVNDNDPVFTQPTYE-LRLNEDAAVGSSVLTLQARDRDA--NSV 719
            G P + S+  V ITVLD NDN P F   +   + + ED  VG  V T++A D DA  N  
Sbjct: 1394 GGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453

Query: 720  ITYQLTGGNTRNRFALSSQRGG-GLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLI 777
            + + L  GN    F + +     G + +A PLD ++   Y+L V ASD GT       ++
Sbjct: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513

Query: 778  NVT--DANTHRPVFQSSH-YTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ 834
             VT  D N + PV +S   Y VSV+E+   GT++  + A D D G N+ ++Y I +    
Sbjct: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573

Query: 835  --FRIDPDSGTMYTM-MELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891
              FR+D  SG + T     D E Q  Y L    +D G P  S TT + + I+D NDNAP 
Sbjct: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPM 1633

Query: 892  FLWDFYQGSIFEDAPPS--TSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
            F    Y+  + ++ P +  TS++ + A D D GPNG + Y    G+  +  F I+   GV
Sbjct: 1634 FQQPHYE-VLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVN-TFRIDRHMGV 1691

Query: 950  IRTQRRLDRE-NVAVYNLWALAVDRGSPTP--LSASVEIQVTILDINDNAPMFEKDELEL 1006
            I   + LD E +   Y L   A D+       L+++  + V + DINDN P F +D    
Sbjct: 1692 ITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGP 1751

Query: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAM--VELDF 1064
            F       G  V    A+D D GPN Q+ Y I++GD    F +  + G LR    VELD 
Sbjct: 1752 FEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDR 1811

Query: 1065 EVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT 1121
            E    Y L + A      PL S   V I ++D NDN PVL +  +     +T   NS  +
Sbjct: 1812 ETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPM----NITISENSPVS 1867

Query: 1122 GVIGCIPAHDPDVSDSLNYTF--VQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVS 1179
              +  + A D D   +   TF    GN  R   ++  TG + ++R LD  R  E  + +S
Sbjct: 1868 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTIS 1927

Query: 1180 VSD 1182
            V D
Sbjct: 1928 VKD 1930



 Score =  365 bits (938), Expect = e-100
 Identities = 296/968 (30%), Positives = 472/968 (48%), Gaps = 80/968 (8%)

Query: 250  YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYM-EGLFDERSRGYFRIDSATGAVST- 307
            Y V++ EN   GT ++Q+ A     G    +SYY+ EG  D      FR+D  +G ++T 
Sbjct: 1533 YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA----FRMDRISGEIATR 1588

Query: 308  DSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLE 367
             +  DRE +  + L     D  TP  SATT++ V + D ND++P+F+Q  Y   + E  +
Sbjct: 1589 PAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPD 1648

Query: 368  -VGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTRAVLDREEA-AEYQ 424
             +   ++TI+A D D   N  + Y ++ G   + F+++   GV++    LD E +   Y 
Sbjct: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708

Query: 425  LLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ- 482
            L+V A DQ       L++T TV + V D NDN P F       + P +V       RV  
Sbjct: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD---YEGPFEVTEGQPGPRVWT 1765

Query: 483  --ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP--LDFEDVQKYSLSIKAQD 538
              A DRD G N  + YSI+ G+  G+F +  + G+L V     LD E +  Y+L+I A+D
Sbjct: 1766 FLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARD 1825

Query: 539  GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
             G PPL +S+ +V ++VLD+NDN+P+ ++ P   T+ EN P+   V H+ A DADSG NA
Sbjct: 1826 RGMPPL-SSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNA 1884

Query: 599  RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658
            RL + +           +AG +  A      F I+ ++G +TV   LDRE +  Y   + 
Sbjct: 1885 RLTFNI-----------TAGNRERA------FFINATTGIVTVNRPLDRERIPEYKLTIS 1927

Query: 659  AVDHGSPPMSSSTSVSITVL---DVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA---- 711
              D+   P  +     + ++   D NDN P+FT+ TY+  + E++  G+ +  L      
Sbjct: 1928 VKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILA 1987

Query: 712  --RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVT--ASD- 766
               D+D  +V+TYQL G  +   F ++S  G   +   + +D +     +L +   A D 
Sbjct: 1988 LDADQDIYAVVTYQLLGAQS-GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDI 2046

Query: 767  GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY 826
            G  + TAH+LI + D N +RP F  +  TV + E+ P G S+  ++A DED+G N  + Y
Sbjct: 2047 GLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVY 2106

Query: 827  VIQDPVP-QFRIDPDSGTMYT-MMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILD 884
             I+     +F I   +G +      +D E Q +Y LT++A D G    S T  + ILI D
Sbjct: 2107 RIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDD 2166

Query: 885  ANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQG---GDDGD--- 938
             ND+ P+FL      S+ E A P T I  ++A D D  P  +L Y   G    DD D   
Sbjct: 2167 INDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP--KLEYHIVGIVAKDDTDRLV 2224

Query: 939  ----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTP-LSASV---EIQVTIL 990
                  F +   +G +  +  ++RE VA Y +    +D  S  P  S SV   ++ V +L
Sbjct: 2225 PNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVL 2284

Query: 991  DINDNAPMFEKDELELFVE---ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFF 1047
            D+NDN P F+   +  ++E   E    G+ +  + A DPD+G N  + Y +++     + 
Sbjct: 2285 DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYV 2344

Query: 1048 QL-DLLNGDLRAMVELDFEVRREYVLVVQAT---SAPLVSRATVHILLVDQNDNPPVLPD 1103
            QL D   G + A   +D+E        V+A+   S P  +   V++ +VD NDN P+   
Sbjct: 2345 QLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404

Query: 1104 FQILFNNYVTNKSNSFPTG-VIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQL 1162
                  +Y        P G +I  + A D D  +     +  G+      ++P TG++ +
Sbjct: 2405 -----PSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYV 2459

Query: 1163 SRDLDNNR 1170
               LD  +
Sbjct: 2460 LSSLDREK 2467



 Score =  364 bits (935), Expect = e-100
 Identities = 297/974 (30%), Positives = 453/974 (46%), Gaps = 69/974 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F    Y  AL ENEP+ T +++L A         +++Y +       S     +    G 
Sbjct: 561  FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620

Query: 305  VSTDSVLDRETKETHV--LRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
            +S    LD E     +  L V A+D   PP ++T  +T+ V D ND+ P F +  Y   V
Sbjct: 621  ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 680

Query: 363  RENLEVGYEVLTIRASDRDSPI---NANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREE 419
             EN+  G  VL + A+D D        ++ Y + G     F++N  SG ++T ++LDRE 
Sbjct: 681  VENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST--QFRINARSGEITTTSLLDRET 738

Query: 420  AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVL 479
             +EY L+V A D G      +  ATV I + D NDN+P + +  Y + + E    ++ V 
Sbjct: 739  KSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVT 798

Query: 480  RVQATDRDQGQNAAIHYSILSGNVAGQFY-LHSLSG-------ILDVINPLDFEDVQKYS 531
             V A D D G+N  + YSI   N   +FY L+S +G       +LD  NP   E      
Sbjct: 799  TVVAVDPDLGENGTLVYSIQPPN---KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855

Query: 532  LSIKAQDGGRPPL-INSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAV 590
            + +   D GRPPL   SS  V V +LD+NDN+P F + PF A VLE +P G  +  + A+
Sbjct: 856  IVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAI 915

Query: 591  DADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEV 650
            D D G N  + YR+                 P   P   F I++SSG +    ELDRE +
Sbjct: 916  DLDEGLNGLVSYRM-----------------PVGMPRMDFLINSSSGVVVTTTELDRERI 958

Query: 651  EHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQ 710
              Y   V A D G+P  SS+++++I VLDVND  P F    Y + ++ED      V+ L 
Sbjct: 959  AEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLN 1018

Query: 711  ARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG- 767
              D D   N+ ++Y +TGGN   +F++  +    ++   + LD +    Y+L + A D  
Sbjct: 1019 CTDNDVGLNAELSYFITGGNVDGKFSVGYR--DAVVRTVVGLDRETTAAYMLILEAIDNG 1076

Query: 768  ----TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENAR 823
                  + TA V + V D N +RP+F  S Y  SV ED P G SI  L A D D GE  R
Sbjct: 1077 PVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGR 1136

Query: 824  ITYVI--QDPVPQFRIDPDSG-TMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
            + Y I   +    FRI   +G  M     LD E   ++ L + A ++ +     +  + +
Sbjct: 1137 VWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIV 1196

Query: 881  LILDANDNAPQFLWDFYQG-SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
             + D ND AP F    Y    + E A   TS++ V ATDRDSG  G + Y    G   +G
Sbjct: 1197 YVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG--AEG 1254

Query: 940  DFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF 999
             F I+ ++G+I T   LD E    Y +   A D+  P        + +T+L+  D A  F
Sbjct: 1255 KFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFN-QGFCSVYITLLNELDEAVQF 1313

Query: 1000 EKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQI---VEGDMRHFFQLDLLNGDL 1056
                 E  + EN  +G+ + +++A   D     QI Y+         +  F++D + G +
Sbjct: 1314 SNASYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVI 1371

Query: 1057 RAMVELDFEVRREYVLVVQA-TSAPLV-SRATVHILLVDQNDNPPVLPDFQILFNNYVTN 1114
                 +D E    Y L V A    P V S   V+I ++D+NDN P   DF    ++   +
Sbjct: 1372 TVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRF-DFT---SDSAVS 1427

Query: 1115 KSNSFPTGV-IGCIPAHDPDVSDS--LNYTFVQGN---ELRLLLLDPATGELQLSRDLDN 1168
                 P G  +  + A DPD   +  + ++   GN      ++  + + GE+ ++R LD 
Sbjct: 1428 IPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDR 1487

Query: 1169 NRPLEALMEVSVSD 1182
                  +++V  SD
Sbjct: 1488 EELDHYILQVVASD 1501



 Score =  360 bits (924), Expect = 1e-98
 Identities = 303/993 (30%), Positives = 477/993 (48%), Gaps = 76/993 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F  P Y ++L+EN   GT +L + A     G    VSY+     D+  R  F +D  TG 
Sbjct: 460  FSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS---DDPDR--FSLDKDTGL 514

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
            +   + LD E  +   L + A D      +    I VL  D ND+ P F++  Y   +RE
Sbjct: 515  IMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRE 572

Query: 365  NLEVGYEVLTIRASDRDSPINANLRYRVLG----GAWDVFQLNESSGVVSTRAVLDREEA 420
            N     +++ +RA+D DSP N  + Y ++     G++    L E  GV+S    LD E+ 
Sbjct: 573  NEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQI 632

Query: 421  AE--YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
            +     L V A D G NP PL++T  V IEV DENDN P FS+  Y V V E++     V
Sbjct: 633  SNGLIYLTVMAMDAG-NP-PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATV 690

Query: 479  LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD 538
            L + ATD D+ +       I S   + QF +++ SG +   + LD E   +Y L ++A D
Sbjct: 691  LFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVD 750

Query: 539  GGRPPLINSS-GVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597
            GG      +    V++ +LD+NDN P +  +P+   ++E  P    V  + AVD D GEN
Sbjct: 751  GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGEN 810

Query: 598  ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI-TVCAELDREEVEHY--- 653
              L Y +                     P+  + +++++G I T  A LDRE  + +   
Sbjct: 811  GTLVYSI-------------------QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851

Query: 654  ---SFGVEAVDHGSPPM--SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708
                  V   D G PP+  +SS +V + +LD+NDNDP F    +   + E    G S+  
Sbjct: 852  LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQ 911

Query: 709  LQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
            + A D D   N +++Y++  G  R  F ++S    G++     LD ++  +Y L V ASD
Sbjct: 912  VVAIDLDEGLNGLVSYRMPVGMPRMDFLINS--SSGVVVTTTELDRERIAEYQLRVVASD 969

Query: 767  G---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENAR 823
                T+S T+ + I+V D N   P F  + Y VSVSED P    +  L+  D D G NA 
Sbjct: 970  AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAE 1029

Query: 824  ITYVIQ--DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK--SDTTTLE 879
            ++Y I   +   +F +      + T++ LD E   AY L + A DNG   K  + T T+ 
Sbjct: 1030 LSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVF 1089

Query: 880  ILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
            + +LD NDN P FL   Y+ S+ ED P   SILQ+ ATD D G  GR+ Y    G+ G+ 
Sbjct: 1090 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGN- 1148

Query: 940  DFYIEPTSGVI-RTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPM 998
            +F I  ++G++ R  R LDRE  + + L   A +     P+ +SV + V + DIND AP+
Sbjct: 1149 NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNH-DLGPMRSSVRVIVYVEDINDEAPV 1207

Query: 999  FEKDEL-ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLR 1057
            F + +   L + E   +G+ V  ++A D D G    + Y+I+ G     F++D   G + 
Sbjct: 1208 FTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLII 1266

Query: 1058 AMVELDFEVRREYVLVVQAT-SAPLVSR--ATVHILLVDQNDNPPVLPDFQILFNN--YV 1112
             +  LD+E +  Y++ V AT  AP  ++   +V+I L+++ D         + F+N  Y 
Sbjct: 1267 TVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDE-------AVQFSNASYE 1319

Query: 1113 TNKSNSFPTGV-IGCIPAHDPDVSDSLNYTF---VQGNELRLLLLDPATGELQLSRDLDN 1168
                 +   G  I  + A+  D  + + Y F          L  +D  TG + +   +D 
Sbjct: 1320 AAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDR 1379

Query: 1169 NRPLEALMEVSVSDGIHSVTAFCTLRVTIITDD 1201
             +     + V   DG   V +   + +T++ ++
Sbjct: 1380 EKGDFYTLTVVADDGGPKVDSTVKVYITVLDEN 1412



 Score =  358 bits (920), Expect = 3e-98
 Identities = 296/962 (30%), Positives = 449/962 (46%), Gaps = 87/962 (9%)

Query: 256  ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA--VSTDSVLDR 313
            E +P G  +    AH    G   +V Y    + D    G F I    G   V  D  LDR
Sbjct: 1756 EGQP-GPRVWTFLAHDRDSGPNGQVEY---SIMDGDPLGEFVISPVEGVLRVRKDVELDR 1811

Query: 314  ETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVL 373
            ET   + L + A D   PP S+T  + + V D ND+ PV         + EN  V   V 
Sbjct: 1812 ETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVA 1871

Query: 374  TIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQ 432
             + ASD DS  NA L + +  G  +  F +N ++G+V+    LDRE   EY+L +   D 
Sbjct: 1872 HVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN 1931

Query: 433  GRNPGPLSATATVY-IEVEDENDNYPQFSEQNYVVQVPED--VGLNTAVLR--VQATDRD 487
              NP        +  I + DENDN+P F++  Y  +V E+   G    VL   + A D D
Sbjct: 1932 PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDAD 1991

Query: 488  QGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYS-----LSIKAQDGGRP 542
            Q   A + Y +L G  +G F ++S +G++ V + +   D + +S     L + A+D G  
Sbjct: 1992 QDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVII-DREAFSPPILELLLLAEDIG-- 2047

Query: 543  PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHY 602
             L+NS+  + + +LD NDN P F  +     +LEN P G+ V+ + A D DSG N  L Y
Sbjct: 2048 -LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVY 2106

Query: 603  RLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVC-AELDREEVEHYSFGVEAVD 661
            R+            AG ++        F IH  +G I V  A +DREE E Y   V A D
Sbjct: 2107 RI-----------EAGAQDR-------FLIHLVTGVIRVGNATIDREEQESYRLTVVATD 2148

Query: 662  HGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVIT 721
             G+ P+S +  V+I + D+ND+ P F  P   + + E A  G+ +  + A D D N  + 
Sbjct: 2149 RGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLE 2208

Query: 722  YQLTG-----------GNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAV--TASD-- 766
            Y + G            N  + FA++   G  ++   +  +     +  L+V   ASD  
Sbjct: 2209 YHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLP 2268

Query: 767  --GTRSHTAHVLINVTDANTHRPVFQS---SHYTVSVSEDRPVGTSIATLSANDEDTGEN 821
                    A + +NV D N + P F+    ++Y   + E    GT++  ++A D D G N
Sbjct: 2269 ERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLN 2328

Query: 822  ARITYVIQDPVPQFRI---DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTL 878
              +TY + D VP   +   D  +G +     +DYE       T+ A DNG P ++    +
Sbjct: 2329 GLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPV 2388

Query: 879  EILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGD 938
             + I+D NDN P F    YQ ++FED P  T IL V+ATD DSG    + Y+     DG+
Sbjct: 2389 YLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL---GDGE 2445

Query: 939  GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA---SVEIQVTILDINDN 995
              F I PT+G I     LDRE    Y L ALA D       +    SV++ + +LD+ND 
Sbjct: 2446 SKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDC 2505

Query: 996  APMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGD 1055
             P F K +    V EN P G+ V  + A D DEGPN ++ Y + EG     F +D+ +G 
Sbjct: 2506 RPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGL 2564

Query: 1056 LRAMVELDFEVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVL---PDFQIL-F 1108
            +     L  +   ++ L V AT     PL     + + ++D NDN PV    P+  IL  
Sbjct: 2565 VTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHI 2622

Query: 1109 NNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQ--GN-ELRLLLLDPATGELQLSRD 1165
               +  +SN +           D  ++ ++ Y+F++  GN +    ++DP +G +Q ++ 
Sbjct: 2623 REEIPLRSNVYEVYATD----KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678

Query: 1166 LD 1167
            LD
Sbjct: 2679 LD 2680



 Score =  334 bits (857), Expect = 7e-91
 Identities = 278/915 (30%), Positives = 443/915 (48%), Gaps = 88/915 (9%)

Query: 362  VRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTRAVLDREEA 420
            + E+  VG  V  + A D D   N  L + V G  A   F +   +GVV  R  LDRE  
Sbjct: 42   ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98

Query: 421  AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480
            +E+ +    +D   + G +  T  V I+V D NDN P F  Q Y V++PE+  + T +  
Sbjct: 99   SEFTVEFSVSD---HQGVI--TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI 153

Query: 481  VQATDRDQGQNAAIHYSILSGNVAGQFY-LHSLSGILDVINPLDFEDVQKYSLSIKAQDG 539
            V ATD D G   ++ YS        QF+ + S  GI+ VI  LD+E  Q Y L++ A D 
Sbjct: 154  VNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210

Query: 540  GRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENAR 599
             +   +++   +++ + DV D +PIF++ P+   + E+ P G  V  I A+D D G    
Sbjct: 211  DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270

Query: 600  LHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREE-VEHYSF--- 655
            + Y +V   +  +                 F +   SG +T+   LDRE  +  + F   
Sbjct: 271  IGYTIVSGNTNSI-----------------FALDYISGVLTLNGLLDRENPLYSHGFILT 313

Query: 656  --GVEAVDHGSPPMSS-STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV-LTLQA 711
              G E  D  +P  ++ +T+ +I V+D+NDN P F    Y + + E A VG ++ L +Q 
Sbjct: 314  VKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQV 373

Query: 712  RDRDAN----SVITYQLTGGNTRNRFALSSQRGGGL----ITLALPLDYKQEQQYVLAVT 763
             D+D N    S+    L G N+ + F +S     G     I +A+PLDY+   +Y   + 
Sbjct: 374  VDKDENLGLNSMFEVYLVGNNSHH-FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLF 432

Query: 764  ASDGTRSHTAHVLINVT--DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGEN 821
            A++    H  +  + +T  + N +RP+F    Y +S+ E+  VGTS+ T+ A D D G  
Sbjct: 433  ANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTF 492

Query: 822  ARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEIL 881
              ++Y   D   +F +D D+G +  +  LDYE    +TLTI+A+D G   +  T  + I 
Sbjct: 493  GEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRIN 550

Query: 882  ILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG-- 939
            +LD NDN P F  D Y G++ E+ P  T ++++ ATD DS PN ++ Y+           
Sbjct: 551  VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610

Query: 940  DFYIEPTSGVIRTQRRLDRENVA--VYNLWALAVDRGSPTPLSASVEIQVTILDINDNAP 997
            D  +    GVI   R LD E ++  +  L  +A+D G+P PL+++V + + + D NDN P
Sbjct: 611  DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-PLNSTVPVTIEVFDENDNPP 669

Query: 998  MFEKDELELFVEENNPVGSVVAKIRANDPD---EGPNAQIMYQIVEGDMRHFFQLDLLNG 1054
             F K    + V EN   G+ V  + A D D   E     I+Y + EG  +  F+++  +G
Sbjct: 670  TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ--FRINARSG 726

Query: 1055 DLRAMVELDFEVRREYVLVVQATSAPL-----VSRATVHILLVDQNDNPPVLPDFQILFN 1109
            ++     LD E + EY+L+V+A    +        ATV+I L+D NDN P   D     N
Sbjct: 727  EITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYIN 786

Query: 1110 NYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSR---DL 1166
                   +S  T V+    A DPD+ ++    +      +   L+  TG+++ +    D 
Sbjct: 787  LVEMTPPDSDVTTVV----AVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDR 842

Query: 1167 DNNRPLEA-LME---VSVSD-GIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLS 1221
            +N  P EA LM    VSV+D G   + A  +  V +   D+  N  T   +N+       
Sbjct: 843  ENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT--FQNL------- 893

Query: 1222 PLLALFVEGVAAVLS 1236
            P +A  +EG+ A +S
Sbjct: 894  PFVAEVLEGIPAGVS 908



 Score =  330 bits (847), Expect = 1e-89
 Identities = 300/988 (30%), Positives = 454/988 (45%), Gaps = 76/988 (7%)

Query: 256  ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315
            E+ P G+ + QL A    + + + + + + G  +E SR +F ++  TG V     LDRET
Sbjct: 44   EDTPVGSSVTQLLAQ---DMDNDPLVFGVSG--EEASR-FFAVEPDTGVVWLRQPLDRET 97

Query: 316  KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTI 375
            K    +     D+       T  + + V D ND++P F    Y  R+ EN  VG  +  +
Sbjct: 98   KSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154

Query: 376  RASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRN 435
             A+D D     ++ Y     +   F ++ + G+V+    LD E    YQL V A DQ + 
Sbjct: 155  NATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKT 213

Query: 436  PGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIH 495
              PLS  A + I + D  D  P F    Y   + E     T V  + A D+D+G+   I 
Sbjct: 214  -RPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272

Query: 496  YSILSGNVAGQFYLHSLSGILDVINPLDFED---VQKYSLSIKA---QDGGRPPLINSSG 549
            Y+I+SGN    F L  +SG+L +   LD E+      + L++K     D   P     + 
Sbjct: 273  YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332

Query: 550  VVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV-VHIQAVDADSGENARLHYRLVDTA 608
              ++ V+D+NDN P F SS +   + E   +G+ + + IQ VD D  EN  L+       
Sbjct: 333  TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD--ENLGLN----SMF 386

Query: 609  STFLGGGSAGPKNPAPTPDFPFQIHNSSG-WITVCAELDREEVEHYSFGVEAVDHGSPPM 667
              +L G ++     +PT      +   +   I V   LD E V+ Y F + A +   P  
Sbjct: 387  EVYLVGNNSHHFIISPT-----SVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDH 440

Query: 668  SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGG 727
                 V IT+++ NDN P+F+QP Y + L E+  VG+SVLT+ A D DA +         
Sbjct: 441  VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS 500

Query: 728  NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVTDANTHR 786
            +  +RF+L   +  GLI L   LDY+  Q++ L + A D G    T  V INV D N + 
Sbjct: 501  DDPDRFSL--DKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNV 558

Query: 787  PVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVP-----QFRIDPDS 841
            P FQ   Y  ++ E+ P  T +  L A DED+  N +ITY I             +    
Sbjct: 559  PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY 618

Query: 842  GTMYTMMELDYE---NQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQ 898
            G +     LDYE   N + Y LT+MA D G P  + T  + I + D NDN P F    Y 
Sbjct: 619  GVISVSRPLDYEQISNGLIY-LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYF 677

Query: 899  GSIFEDAPPSTSILQVSATDRD-SGPNGR--LLYTFQGGDDGDGDFYIEPTSGVIRTQRR 955
             S+ E+     ++L ++ATD D S   G+  ++Y+ +G       F I   SG I T   
Sbjct: 678  VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST----QFRINARSGEITTTSL 733

Query: 956  LDRENVAVYNLWALAVDRG-SPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPV 1014
            LDRE  + Y L   AVD G      +    + +T+LDINDN P ++     + + E  P 
Sbjct: 734  LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793

Query: 1015 GSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLR---AMVEL------DFE 1065
             S V  + A DPD G N  ++Y I   +   F+ L+   G +R   AM++       + E
Sbjct: 794  DSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851

Query: 1066 VRREYVLVVQATSAP---LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG 1122
            + R+ V+ V     P     S ATV + L+D NDN P    FQ L   +V       P G
Sbjct: 852  LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT---FQNL--PFVAEVLEGIPAG 906

Query: 1123 V-IGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVS 1179
            V I  + A D D  ++  ++Y    G      L++ ++G +  + +LD  R  E  + V 
Sbjct: 907  VSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVV 966

Query: 1180 VSDG---IHSVTAFCTLRVTIITDDMLT 1204
             SD      S T+  T+ V  + D+  T
Sbjct: 967  ASDAGTPTKSSTSTLTIHVLDVNDETPT 994



 Score =  314 bits (804), Expect = 1e-84
 Identities = 268/879 (30%), Positives = 418/879 (47%), Gaps = 74/879 (8%)

Query: 245  FPMPNYQVALFEN-EPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            F  P+Y+V L E  +   T ++ + A    EG    V+Y    +        FRID   G
Sbjct: 1634 FQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTY---AIVAGNIVNTFRIDRHMG 1690

Query: 304  AVSTDSVLDRETKE-THVLRVKAVDYS---TPPRSATTYITVLVKDTNDHSPVFEQS-EY 358
             ++    LD E     + L V A D     +   ++TT + V V D ND+ P F +  E 
Sbjct: 1691 VITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEG 1750

Query: 359  RERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTR--AVL 415
               V E  + G  V T  A DRDS  N  + Y ++ G     F ++   GV+  R    L
Sbjct: 1751 PFEVTEG-QPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVEL 1809

Query: 416  DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLN 475
            DRE  A Y L + A D+G  P  LS+T  V I V D NDN P        + + E+  ++
Sbjct: 1810 DRETIAFYNLTICARDRGMPP--LSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVS 1867

Query: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
            + V  V A+D D G NA + ++I +GN    F++++ +GI+ V  PLD E + +Y L+I 
Sbjct: 1868 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTIS 1927

Query: 536  AQDGGRPPLI--NSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVV----HIQA 589
             +D    P I      ++ + + D NDN P+F  S +QA V+EN P G P+      I A
Sbjct: 1928 VKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILA 1987

Query: 590  VDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE--LDR 647
            +DAD    A + Y+L+   S                    F I++S+G +TV +   +DR
Sbjct: 1988 LDADQDIYAVVTYQLLGAQSGL------------------FDINSSTGVVTVRSGVIIDR 2029

Query: 648  EEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL 707
            E        +  +      ++S+  + IT+LD NDN P F+  T  + L E+   G SVL
Sbjct: 2030 EAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVL 2089

Query: 708  TLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTAS 765
             + A D D+  N  + Y++  G  ++RF +    G   +  A  +D ++++ Y L V A+
Sbjct: 2090 QVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNA-TIDREEQESYRLTVVAT 2147

Query: 766  D-GT--RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENA 822
            D GT   S TA V I + D N  RP F +   TVSV E    GT IA ++A D D   N 
Sbjct: 2148 DRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NP 2205

Query: 823  RITY-------------VIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNG- 868
            ++ Y             ++ +    F ++ ++G++     ++ E    Y +T+   DN  
Sbjct: 2206 KLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNAS 2265

Query: 869  -IPQKS---DTTTLEILILDANDNAPQFL---WDFYQGSIFEDAPPSTSILQVSATDRDS 921
             +P++S       L + +LD NDN PQF      +Y   I E A P T+++ V+A D D 
Sbjct: 2266 DLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDK 2325

Query: 922  GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981
            G NG + YT             + ++G +   R +D E V   N    A D GSP P +A
Sbjct: 2326 GLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP-PRAA 2384

Query: 982  SVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEG 1041
             + + + I+DINDN P+F++   +  V E+ PVG+++  + A D D G  A I Y + +G
Sbjct: 2385 EIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG 2444

Query: 1042 DMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP 1080
            + +  F ++   GD+  +  LD E +  Y+L   A   P
Sbjct: 2445 ESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 2481



 Score =  313 bits (802), Expect = 2e-84
 Identities = 255/844 (30%), Positives = 396/844 (46%), Gaps = 89/844 (10%)

Query: 252  VALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVST-DSV 310
            V L EN P G  +LQ+ A     G    + Y +E    +R    F I   TG +   ++ 
Sbjct: 2076 VHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR----FLIHLVTGVIRVGNAT 2131

Query: 311  LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370
            +DRE +E++ L V A D  T P S T  +T+L+ D ND  P F        V E+ E G 
Sbjct: 2132 IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGT 2191

Query: 371  EVLTIRASDRDSPINANLRYRVLG------------GAWDVFQLNESSGVVSTRAVLDRE 418
             +  I A D D  +N  L Y ++G               D F +N ++G V  ++ ++RE
Sbjct: 2192 VIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRE 2249

Query: 419  EAAEYQLLVEANDQGRNPGPLSAT---ATVYIEVEDENDNYPQFSEQN---YVVQVPEDV 472
              A Y++ +   D   +    S +   A + + V D NDN PQF       Y+ ++ E  
Sbjct: 2250 LVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGA 2309

Query: 473  GLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN-PLDFEDVQKYS 531
               T ++ V A D D+G N  + Y++L     G   L   S    + N  +D+E+V   +
Sbjct: 2310 TPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLN 2369

Query: 532  LSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVD 591
             +++A D G PP      V  ++++D+NDN PIF    +Q  V E+VP+G  ++ + A D
Sbjct: 2370 FTVRASDNGSPPRAAEIPVY-LEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATD 2428

Query: 592  ADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVE 651
            ADSG  A + Y L D  S F                    I+ ++G I V + LDRE+ +
Sbjct: 2429 ADSGNFALIEYSLGDGESKFA-------------------INPTTGDIYVLSSLDREKKD 2469

Query: 652  HYSFGVEAVDH----GSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL 707
            HY     A D+     S    +S  V I VLDVND  P F++P +   + E+   G+SV+
Sbjct: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI 2529

Query: 708  TLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTAS 765
            T+ A D+D   N  +TY L G       A       GL+T   PL  +  +++ L V A+
Sbjct: 2530 TMMATDQDEGPNGELTYSLEGPGVE---AFHVDMDSGLVTTQRPL--QSYEKFSLTVVAT 2584

Query: 766  DGTRSH---TAHVLINVTDANTHRPVF--QSSHYTVSVSEDRPVGTSIATLSANDEDTGE 820
            DG       T  +L+ V D N +RPVF    +   + + E+ P+ +++  + A D+D G 
Sbjct: 2585 DGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGL 2644

Query: 821  NARITYVIQDPVPQ-----FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDT 875
            N  + Y             F IDP SG + T   LD E+Q  Y+L ++A D G P   +T
Sbjct: 2645 NGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYET 2704

Query: 876  TT-LEILILDANDNAPQFLW------DFYQGSIFEDAPPSTSILQVS-ATDRDSGPNGRL 927
               L++ + D +DN P F+        +   ++ E +P  T +  V+ A D D GPN  +
Sbjct: 2705 MQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIV 2764

Query: 928  LYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTP--------- 978
             Y    G++ + +F+++P  G +   R LDRE  A+++    A    S TP         
Sbjct: 2765 YYFIAAGNE-EKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLD 2822

Query: 979  LSASV---EIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIM 1035
            L A +   E++V + DIND  P F K E    V  +  VGS + ++ A D D G N+ + 
Sbjct: 2823 LVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882

Query: 1036 YQIV 1039
            Y I+
Sbjct: 2883 YSIL 2886



 Score =  183 bits (465), Expect = 2e-45
 Identities = 150/521 (28%), Positives = 238/521 (45%), Gaps = 33/521 (6%)

Query: 685  PVFTQPTYE--LRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGG 742
            P FT   ++  L ++ED  VGSSV  L A+D D N  + + ++G      FA+    G  
Sbjct: 29   PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTG-- 85

Query: 743  LITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDR 802
            ++ L  PLD + + ++ +  + SD     T  V I V D N + P F +  Y+V + E+ 
Sbjct: 86   VVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145

Query: 803  PVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTI 862
            PVGT I  ++A D D G    + Y  Q P   F ID   G +  + ELDYE   AY LT+
Sbjct: 146  PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTV 205

Query: 863  MAQDNGIPQKSDT-TTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDS 921
             A D    +   T   L I+I D  D  P F+   Y  +I+E +PP T++  ++A D+D 
Sbjct: 206  NATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265

Query: 922  GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAV------DRGS 975
            G    + YT   G+  +  F ++  SGV+     LDREN    + + L V      D  +
Sbjct: 266  GRPRGIGYTIVSGNT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324

Query: 976  PTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVG-SVVAKIRANDPDEGPNAQI 1034
            P+  + +    + ++DINDNAP F   E  + + E   VG ++   I+  D DE      
Sbjct: 325  PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384

Query: 1035 MYQI-VEGDMRHFFQLDLLNGD------LRAMVELDFEV--RREYVLVVQATSAPLVSRA 1085
            M+++ + G+  H F +   +        +R  + LD+E   R ++ L    +    V  A
Sbjct: 385  MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYA 444

Query: 1086 TVHILLVDQNDNPPVL--PDFQI-LFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTF 1142
             V I L+++NDN P+   P + I L+ N     S       +  + A D D       ++
Sbjct: 445  KVKITLINENDNRPIFSQPLYNISLYENVTVGTS-------VLTVLATDNDAGTFGEVSY 497

Query: 1143 VQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDG 1183
               ++     LD  TG + L   LD        + +   DG
Sbjct: 498  FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDG 538



 Score =  161 bits (407), Expect = 1e-38
 Identities = 120/387 (31%), Positives = 189/387 (48%), Gaps = 33/387 (8%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +F  P +  +++ENEPAGT ++ + A    EG    ++Y +EG   E     F +D  +G
Sbjct: 2508 QFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA----FHVDMDSG 2563

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE--R 361
             V+T   L  ++ E   L V A D   PP   TT + V V D ND+ PVF +        
Sbjct: 2564 LVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILH 2621

Query: 362  VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGA----WDVFQLNESSGVVSTRAVLDR 417
            +RE + +   V  + A+D+D  +N  +RY  L  A    W+ F ++  SG++ T   LDR
Sbjct: 2622 IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDR 2681

Query: 418  EEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQF------SEQNYVVQVPED 471
            E  A Y L++ A+D G+ P P      + + +ED +DN P F      S Q  ++ VPE 
Sbjct: 2682 ESQAVYSLILVASDLGQ-PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEH 2740

Query: 472  VGLNTAVLRVQ-ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKY 530
                T V  V  A D D+G NA ++Y I +GN    F+L    G L V+  LD E    +
Sbjct: 2741 SPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIF 2799

Query: 531  SLSIKAQDG-------GRPPLINSSGVVSVQVL-----DVNDNEPIFVSSPFQATVLENV 578
            S  +KA          G  P ++    +++Q +     D+ND  P F  + + A V  + 
Sbjct: 2800 SFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDA 2859

Query: 579  PLGYPVVHIQAVDADSGENARLHYRLV 605
             +G  ++ + A+DAD G N+ + Y ++
Sbjct: 2860 KVGSELIQVLALDADIGNNSLVFYSIL 2886



 Score = 75.9 bits (185), Expect = 6e-13
 Identities = 80/291 (27%), Positives = 127/291 (43%), Gaps = 30/291 (10%)

Query: 256  ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315
            E  P  + + +++A    EG    V Y        R   +F ID  +G + T   LDRE+
Sbjct: 2624 EEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRES 2683

Query: 316  KETHVLRVKAVDYSTP-PRSATTYITVLVKDTNDHSPVFEQS-----EYRE-RVRENLEV 368
            +  + L + A D   P P      + V ++D +D+ P+F +      +Y+   V E+   
Sbjct: 2684 QAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPR 2743

Query: 369  GYEVLTIR-ASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLV 427
            G  V  +  A D D   NA + Y +  G  +     +  G +     LDRE  A +  +V
Sbjct: 2744 GTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIV 2803

Query: 428  EANDQG-----RNPGP---LSATAT---VYIEVEDENDNYPQFSEQNYVVQVPEDVGLNT 476
            +A+        R P P   L A  T   V + +ED ND  P+F++  Y   V  D  + +
Sbjct: 2804 KASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGS 2863

Query: 477  AVLRVQATDRDQGQNAAIHYSIL-----------SGNVAGQFYLHSLSGIL 516
             +++V A D D G N+ + YSIL           S +V   F + S+ GIL
Sbjct: 2864 ELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGIL 2914


>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
          Length = 4349

 Score =  362 bits (930), Expect = 2e-99
 Identities = 281/990 (28%), Positives = 454/990 (45%), Gaps = 113/990 (11%)

Query: 242  SLKFPMPNYQVALFENEPAGTLILQLHA-------HYTIEGEEERVSYYMEGLFDERSRG 294
            SLKF    Y+V L E  P G+ ++ +          Y ++   E V              
Sbjct: 359  SLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSENVG------------- 405

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
             F++++ TG ++T  ++D   +  + L ++     T P  A+T + + + D N+H+P+F 
Sbjct: 406  -FKLNARTGLITTTKLMDFHDRAHYQLHIR-----TSPGQASTVVVIDIVDCNNHAPLFN 459

Query: 355  QSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAV 414
            +S Y   + EN+  G  VL + A+DRD   N  + Y + G     F ++   G++ST   
Sbjct: 460  RSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKP 519

Query: 415  LDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVG 473
            +D E     Y   V A+D G +P       ++++++ + NDN P F E N    + +D  
Sbjct: 520  MDYELMKRIYTFRVRASDWG-SPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWP 578

Query: 474  LNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP---LDFEDVQKY 530
            +  +++ + A D D+ QN  + Y I+SGN    F L+  SG++ +  P   L       Y
Sbjct: 579  VGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSY 636

Query: 531  SLSIKAQDGGR-------------------PPLINSSGVV-------------------- 551
            SL I A DG                     P   + +GV+                    
Sbjct: 637  SLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSD 696

Query: 552  ----SVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVD 606
                S+    +N   P F    P    VLE+VP+  P+  + A D D+G N +L Y + D
Sbjct: 697  EEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIAD 756

Query: 607  TASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPP 666
                   G   G           F I   +G +TV A LD E    Y   V   D G+P 
Sbjct: 757  -------GNEEG----------CFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQ 799

Query: 667  MSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTG 726
             SS   +++ V D NDN P F    Y+L ++ED  VG+++  L  +D D+      + T 
Sbjct: 800  KSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTL 859

Query: 727  GNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSH----TAHVLINVTD 781
             +   +F+L    G  ++T    LD + E +Y+L V A D  ++ H       ++I + D
Sbjct: 860  LSPTEKFSLHPLTGELVVT--GHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLED 917

Query: 782  ANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPV-PQFRIDPD 840
             N + P   + H  + V ED P GT +  L A+D D G    + YV+ D     FR+D  
Sbjct: 918  VNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLM 977

Query: 841  SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTT-LEILILDANDN--APQFLWDFY 897
            +G +    ELD+E +  Y L++ A D G P    T   +E+++LD N+N   P F    +
Sbjct: 978  TGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVH 1037

Query: 898  QGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD 957
            QG + E++P  T ++ V+A D DSG +G L Y  + G  G   F I   +G+I+T   LD
Sbjct: 1038 QGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAG-TGLAAFSINQDTGMIQTLAPLD 1096

Query: 958  RENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSV 1017
            RE  + Y L  LAVDRGS  PLS+  E+ + + D NDN P   +      ++E+ PVG+ 
Sbjct: 1097 REFASYYWLTVLAVDRGS-VPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTS 1155

Query: 1018 VAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVL---VV 1074
            V ++ A DPD     ++ + I  G+   FF +  + G L    +LD E + E++L   V+
Sbjct: 1156 VLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215

Query: 1075 QATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDV 1134
                  L S + V + ++D NDNPP+      LFN  +  + +    G +  + A D D 
Sbjct: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFS--HKLFNVRLPERLSPVSPGPVYRLVASDLDE 1273

Query: 1135 SDSLNYTF-VQGNELRLLLLDPATGELQLS 1163
              +   T+ ++ ++     +D  TG +  S
Sbjct: 1274 GLNGRVTYSIEDSDEEAFSIDLVTGVVSSS 1303



 Score =  348 bits (894), Expect = 4e-95
 Identities = 274/936 (29%), Positives = 450/936 (48%), Gaps = 66/936 (7%)

Query: 256  ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315
            E+ P GT++  L A     G    V Y +     + + G FR+D  TGA+  +  LD E 
Sbjct: 936  EDLPPGTVLTFLDASDPDLGPAGEVRYVLM----DGAHGTFRVDLMTGALILERELDFER 991

Query: 316  KETHVLRVKAVDYSTP-PRSATTYITVLVKDTND--HSPVFEQSEYRERVRENLEVGYEV 372
            +  + L + A D   P  R    ++ V+V D N+  H P F    ++ +V+EN   G +V
Sbjct: 992  RAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV 1051

Query: 373  LTIRASDRDSPINANLRYRVLGGAW-DVFQLNESSGVVSTRAVLDREEAAEYQLLVEAND 431
            + + A D DS ++  L+Y +  G     F +N+ +G++ T A LDRE A+ Y L V A D
Sbjct: 1052 IVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVD 1111

Query: 432  QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
            +G  P  LS+   VYIEV D NDN PQ S+  +   + ED  + T+VL++ A D D    
Sbjct: 1112 RGSVP--LSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSK 1169

Query: 492  AAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVV 551
              + ++I SGN  G F +H ++G+L     LD E+  ++ L +   D G P L ++S VV
Sbjct: 1170 GKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVV 1229

Query: 552  SVQVLDVNDNEPIFVSSPFQATVLENV-PLG-YPVVHIQAVDADSGENARLHYRLVDTAS 609
             V +LDVNDN PIF    F   + E + P+   PV  + A D D G N R+ Y + D+  
Sbjct: 1230 -VGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDS-- 1286

Query: 610  TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
                         A + D    + +SS   T          E+    ++A D G PP+S+
Sbjct: 1287 ----------DEEAFSIDLVTGVVSSSSTFTA--------GEYNILTIKATDSGQPPLSA 1328

Query: 670  STSVSITVLDVNDNDPV---FTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTG 726
            S  + I  +       +   F +  Y   + E   V   V  +    R    +  + ++G
Sbjct: 1329 SVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRP--GLFWFNISG 1386

Query: 727  GNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHV-LINVTDANTH 785
            G+    F +  ++  G I +A PLD ++   Y L V  +DG+R+    V +  + + N H
Sbjct: 1387 GDKDMDFDI--EKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIATQVHIFMIANINHH 1444

Query: 786  RPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARIT-YVIQDP--VPQFRIDPDSG 842
            RP F  + Y V V +D   G  +  + A D+D G++   T +  QDP     F++DP SG
Sbjct: 1445 RPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSG 1504

Query: 843  TMYTMMELDY-ENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSI 901
             + T+ +LD       +TLT+M +D  IP K +   + I + D N + P+F    Y+ S+
Sbjct: 1505 VLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASV 1564

Query: 902  FEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
             +   P T +LQV A D D G N  + Y+   G + +G F I    G+I   ++LD+ N 
Sbjct: 1565 PDTIAPGTELLQVRAMDADRGVNAEVHYSLLKG-NSEGFFNINALLGIITLAQKLDQANH 1623

Query: 962  AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKI 1021
            A + L   A D+GSP     +  I + +   + +AP+F K E  + + E+ PVGS +  +
Sbjct: 1624 APHTLTVKAEDQGSPQWHDLATVI-IHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLV 1682

Query: 1022 RANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATS-AP 1080
             A  P E     + Y++ EG+    F ++  +G +    +LD E    Y L ++ ++ A 
Sbjct: 1683 SAMSPSE-----VTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAG 1737

Query: 1081 LVSRATVHILLVDQNDNPPV---------LPDFQILFNNYVTNKSNSFPTGVIGCIPAHD 1131
              +   V + ++D+NDN P+         + +   L++  +   +N F   VI    + D
Sbjct: 1738 AFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPF---VIHASDS-D 1793

Query: 1132 PDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLD 1167
             + +  L Y  ++   L+   +DP+ G L +  ++D
Sbjct: 1794 KEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMD 1829



 Score =  335 bits (860), Expect = 3e-91
 Identities = 280/997 (28%), Positives = 456/997 (45%), Gaps = 60/997 (6%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSR-GYFRIDSAT 302
            KF  P Y  +  E+ P G+ I  + A   +  ++  +   + G   E ++ G F +D  T
Sbjct: 2690 KFSEPLYTFSAPEDLPEGSEIGIVKA---VAAQDPVIYSLVRGTTPESNKDGVFSLDPDT 2746

Query: 303  GAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
            G +     +D E+ + + + V A         +   + + V D ND+ PVFE   Y+  +
Sbjct: 2747 GVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVL 2806

Query: 363  RENLEVGYEVLTIRASDRDSPINANLRYRVLG----GAWDVFQLNESSGVVSTRAVLDRE 418
             EN+ VG  V+ + A D+D+  +  + YR+         ++F ++  SG ++T   LD E
Sbjct: 2807 TENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCE 2866

Query: 419  EAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
                Y   V A D G+    LS+ A V + + DENDN P+F+ + Y   V E+      V
Sbjct: 2867 TCQTYHFHVVAYDHGQTI-QLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELV 2925

Query: 479  LRVQATDRD-QGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN--PLDFEDVQKYSLSIK 535
              ++  D D   QN  +   I  G+  GQF +  +     + +   LD E   KY L + 
Sbjct: 2926 ATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVT 2985

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
            A DG       +S  V + VLDVNDN P      +   V E+V  G+ ++ + A D D+ 
Sbjct: 2986 ASDGK----FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTD 3041

Query: 596  ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSF 655
             NA++ Y L        G G+             F++   +G +T    LDRE  + ++ 
Sbjct: 3042 TNAQITYSLH-------GPGA-----------HEFKLDPHTGELTTLTALDRERKDVFNL 3083

Query: 656  GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
              +A D G    S    +++ V DVNDN P F      + + ++  V + V  + ARD D
Sbjct: 3084 VAKATDGGG--RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPD 3141

Query: 716  --ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTR--- 769
              AN+ + Y L   +    F++ +  G  +I L  PL  + +    L V ASD GT    
Sbjct: 3142 QGANAQVVYSLPD-SAEGHFSIDATTG--VIRLEKPLQVRPQAPLELTVRASDLGTPIPL 3198

Query: 770  SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
            S    V ++V     + PVF ++ ++V V ED P GT +  L+       E      V  
Sbjct: 3199 STLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSG 3258

Query: 830  DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNA 889
            +   +FR+D  +G +Y    LD+E    Y L+I          SD TT+ + I D N++ 
Sbjct: 3259 NEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHR 3318

Query: 890  PQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
            PQF  D Y   + E+A     IL VSATD D   N  + Y+  GG+   G F I P  G 
Sbjct: 3319 PQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQ-LGHFTIHPKKGE 3377

Query: 950  IRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVE 1009
            ++  + LDRE  + Y+L   A D G P PL    +I + + D+NDN P F +      V+
Sbjct: 3378 LQVAKALDREQASSYSLKLRATDSGQP-PLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQ 3436

Query: 1010 ENNPVGSVVAKIRANDPDEGPNA-QIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRR 1068
            EN+P+GS V ++  +DPD   N     ++I +G+    F++   +G L     L    + 
Sbjct: 3437 ENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRV-TPDGWLVTAEGLSRRAQE 3495

Query: 1069 EYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIG 1125
             Y L +QA+ +   PL S  +V + + +Q+   P     +I    ++T   + F  G++G
Sbjct: 3496 WYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEI----FITVGEDEFQGGMVG 3551

Query: 1126 CIPAHDPDVSDSLNYTFVQGNEL-RLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGI 1184
             I A D D  D+L Y+  +   L R   +    G++  ++ L           V+VSDG 
Sbjct: 3552 KIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRG---HYSFNVTVSDGT 3608

Query: 1185 HSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLS 1221
             + TA   + V  +  + L  ++ +    ++ E+ +S
Sbjct: 3609 FTTTAGVHVYVWHVGQEALQQAMWMGFYQLTPEELVS 3645



 Score =  323 bits (827), Expect = 2e-87
 Identities = 292/959 (30%), Positives = 445/959 (46%), Gaps = 74/959 (7%)

Query: 252  VALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVL 311
            + + E+ P  T + +L A     G   ++ Y +    D    G F I+  TG ++  + L
Sbjct: 722  IDVLESVPINTPLARLAATDPDAGFNGKLVYVIA---DGNEEGCFDIELETGLLTVAAPL 778

Query: 312  DRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYE 371
            D E    ++L V   D  TP +S+   +TV VKD ND++P F    Y+  + E+ EVG  
Sbjct: 779  DYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTT 838

Query: 372  VLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEAND 431
            +  +   D DS  N  +RY +L    + F L+  +G +     LDRE    Y L VEA D
Sbjct: 839  IAELTTKDADSEDNGRVRYTLLSPT-EKFSLHPLTGELVVTGHLDRESEPRYILKVEARD 897

Query: 432  QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
            Q      L +   + I +ED NDN PQ   ++  ++VPED+   T +  + A+D D G  
Sbjct: 898  QPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPA 957

Query: 492  AAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVV 551
              + Y ++ G   G F +  ++G L +   LDFE    Y+LS+ A DGGRP    +   V
Sbjct: 958  GEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHV 1016

Query: 552  SVQVLDVNDN--EPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
             V VLDVN+N   P F S   Q  V EN P G  V+ + A D DSG +  L Y       
Sbjct: 1017 EVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQY------- 1069

Query: 610  TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
             FL  G         T    F I+  +G I   A LDRE   +Y   V AVD GS P+SS
Sbjct: 1070 -FLRAG---------TGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSS 1119

Query: 670  STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANS--VITYQLTGG 727
             T V I V D NDN P  +Q  +   + EDA VG+SVL L A D D++S   +T+ +T G
Sbjct: 1120 VTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSG 1179

Query: 728  NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANT 784
            N    F +      GL++ A  LD + + +++L VT  D    +   T+ V++ + D N 
Sbjct: 1180 NYMGFFMIHPVT--GLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVND 1237

Query: 785  HRPVFQSSHYTVSVSED-RPVGTS-IATLSANDEDTGENARITYVIQDPVPQ-FRIDPDS 841
            + P+F    + V + E   PV    +  L A+D D G N R+TY I+D   + F ID  +
Sbjct: 1238 NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVT 1297

Query: 842  GTM---YTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI--LILDANDNAP-QFLWD 895
            G +    T    +Y       LTI A D+G P  S +  L I  +      + P  F   
Sbjct: 1298 GVVSSSSTFTAGEYN-----ILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352

Query: 896  FYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRR 955
            +Y  ++ E  P +  +  +S      G  G   +   GGD  D DF IE T+G I   R 
Sbjct: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDK-DMDFDIEKTTGSIVIARP 1407

Query: 956  LDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVG 1015
            LD    + YNL  + V  GS T ++  V I   I +IN + P F +   E+ V ++   G
Sbjct: 1408 LDTRRRSNYNL-TVEVTDGSRT-IATQVHI-FMIANINHHRPQFLETRYEVRVPQDTVPG 1464

Query: 1016 SVVAKIRANDPDEGPNAQIMYQI---VEGDMRHFFQLDLLNGDLRAMVELDF---EVRRE 1069
              + +++A D D+G +  ++Y I    +      FQLD  +G L  + +LD      +  
Sbjct: 1465 VELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHT 1522

Query: 1070 YVLVVQATSAPLVSR---ATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGV-IG 1125
              ++V+    P+       T+H+   D N +PP          +Y  +  ++   G  + 
Sbjct: 1523 LTVMVRDQEIPIKRNFVWVTIHV--EDGNLHPPRFTQL-----HYEASVPDTIAPGTELL 1575

Query: 1126 CIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
             + A D D  V+  ++Y+ ++GN      ++   G + L++ LD        + V   D
Sbjct: 1576 QVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAED 1634



 Score =  318 bits (815), Expect = 5e-86
 Identities = 257/879 (29%), Positives = 409/879 (46%), Gaps = 67/879 (7%)

Query: 242  SLKFPMPNYQVALFEN--EPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRID 299
            SL+F    Y  A+ EN  +    +IL    ++      + +SY++    D      F + 
Sbjct: 1965 SLQFDQDVYWAAVKENLQDRKALVILGAQGNHL----NDTLSYFLLNGTD-----MFHMV 2015

Query: 300  SATGAVSTDSV-LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEY 358
             + G + T  V  DRE ++TH L V+  D  TP R A   + V ++D ND+ P F+   Y
Sbjct: 2016 QSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPY 2075

Query: 359  RERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDRE 418
               +++  E G  +  + A+D D   N  + Y      +  F+++   G +S +   D +
Sbjct: 2076 YTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQ 2134

Query: 419  EAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
               +Y L V A D G     L +   V + V ++++  P F    Y V+VPE++ L T +
Sbjct: 2135 ALNKYHLKVIARDGGTPS--LQSEEEVLVTVRNKSN--PLFQSPYYKVRVPENITLYTPI 2190

Query: 479  LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD 538
            L  QA   +      + Y+I+       F     +G+L V  PLD+E   K+  +++A D
Sbjct: 2191 LHTQARSPE---GLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATD 2247

Query: 539  GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
                    S   V V V DVNDN P F    +  ++ E +P   PV+ + A D DSG N 
Sbjct: 2248 TALGSF--SEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNR 2305

Query: 599  RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658
             + Y++V+  S                  F FQI+ S+G ++   ELD E  +H+   V 
Sbjct: 2306 DVSYQIVEDGSD--------------VSKF-FQINGSTGEMSTVQELDYEAQQHFHVKVR 2350

Query: 659  AVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA-- 716
            A+D G PP++  T V + V D+NDN P F QP YE  ++E A  G  VL +QA D D+  
Sbjct: 2351 AMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRD 2410

Query: 717  NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVL 776
             S + Y +  GN    F ++S    G+I++        +  Y L V ASDG    T  V 
Sbjct: 2411 TSRLEYLILSGNQDRHFFINS--SSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVY 2468

Query: 777  INVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPV--PQ 834
            IN T+AN + P FQ   Y   ++E+  VGT +  L A D+D+G    I Y I + +   +
Sbjct: 2469 INTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEK 2528

Query: 835  FRIDPDSGTMYTMMELDYENQV--AYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
            F I+P +G + T+ +LD EN       + +MA+D G   +    T++I++ D NDN PQF
Sbjct: 2529 FSINP-NGQIATLQKLDRENSTERVIAIKVMARDGG--GRVAFCTVKIILTDENDNPPQF 2585

Query: 893  LWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRT 952
                Y  SI  +    + ++QV A D D G N  + Y+    D       I P +GV++ 
Sbjct: 2586 KASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKV 2645

Query: 953  QRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENN 1012
            +  L        + +  A D G P   ++ V +++ ++    + P F +        E+ 
Sbjct: 2646 KDSLVGLENQTLDFFIKAQD-GGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDL 2704

Query: 1013 PVGS---VVAKIRANDPDEGPNAQIMYQIVEG-----DMRHFFQLDLLNGDLRAMVELDF 1064
            P GS   +V  + A DP       ++Y +V G     +    F LD   G ++    +D 
Sbjct: 2705 PEGSEIGIVKAVAAQDP-------VIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDH 2757

Query: 1065 EVRREYVLVVQA---TSAPLVSRATVHILLVDQNDNPPV 1100
            E  + Y + V A    +  +VS  +V+I + D NDN PV
Sbjct: 2758 ESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPV 2796



 Score =  296 bits (758), Expect = 2e-79
 Identities = 270/979 (27%), Positives = 435/979 (44%), Gaps = 74/979 (7%)

Query: 250  YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDS 309
            +Q  + EN P+GT ++ + A     G +  + Y++           F I+  TG + T +
Sbjct: 1037 HQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRA---GTGLAAFSINQDTGMIQTLA 1093

Query: 310  VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVG 369
             LDRE    + L V AVD  + P S+ T + + V D ND+ P   Q+ +   ++E+  VG
Sbjct: 1094 PLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG 1153

Query: 370  YEVLTIRASDRDSPINANLRYRVLGGAW-DVFQLNESSGVVSTRAVLDREEAAEYQLLVE 428
              VL + A D DS     L + +  G +   F ++  +G++ST   LDRE   E+ L V 
Sbjct: 1154 TSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVT 1213

Query: 429  ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTA--VLRVQATDR 486
              D G     L +T+ V + + D NDN P FS + + V++PE +   +   V R+ A+D 
Sbjct: 1214 VLDNGEPS--LKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDL 1271

Query: 487  DQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLIN 546
            D+G N  + YSI   +    F +  ++G+  V +   F   +   L+IKA D G+PPL  
Sbjct: 1272 DEGLNGRVTYSIEDSDEEA-FSIDLVTGV--VSSSSTFTAGEYNILTIKATDSGQPPL-- 1326

Query: 547  SSGVVSVQVLDVNDNEPIFVSSPFQATVLE-NVPLGYPVVHIQAVDADSGENARLHYRLV 605
             S  V + +  +    P  +   F  T     V    PV H+  V +  G      + + 
Sbjct: 1327 -SASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNI- 1384

Query: 606  DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP 665
                      S G K      D  F I  ++G I +   LD     +Y+  VE  D GS 
Sbjct: 1385 ----------SGGDK------DMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD-GSR 1427

Query: 666  PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLT 725
             +++   + + + ++N + P F +  YE+R+ +D   G  +L +QA D+D    + Y + 
Sbjct: 1428 TIATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIH 1486

Query: 726  GGNTRNRFALSS-QRGGGLITLALPLDYKQ-EQQYVLAVTASDGT---RSHTAHVLINVT 780
            G       +L       G++     LD      Q+ L V   D     + +   V I+V 
Sbjct: 1487 GSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVE 1546

Query: 781  DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRID 838
            D N H P F   HY  SV +    GT +  + A D D G NA + Y +     +  F I+
Sbjct: 1547 DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNIN 1606

Query: 839  PDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQ 898
               G +    +LD  N   +TLT+ A+D G PQ  D  T+ I +  ++ +AP F    Y 
Sbjct: 1607 ALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYF 1666

Query: 899  GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDR 958
              I E  P  + IL VSA          + Y  + G+  DG F +   SG+I TQ++LD 
Sbjct: 1667 VEIPESIPVGSPILLVSAMSPSE-----VTYELREGNK-DGVFSMNSYSGLISTQKKLDH 1720

Query: 959  ENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVV 1018
            E ++ Y L    +   +       V + V I+D NDNAPMF K      + E  P+ S++
Sbjct: 1721 EKISSYQL---KIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMI 1777

Query: 1019 AK-------IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
                     I A+D D+  N+ ++Y+I+E +   FF++D   G L  + E+D+E    + 
Sbjct: 1778 MDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQ 1837

Query: 1072 LVVQATS-------APLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVI 1124
              V           AP  ++  +H+   D ND+PP   + QI     V       P   +
Sbjct: 1838 FCVYVHDQGSPVLFAPRPAQVIIHVR--DVNDSPPRFSE-QIY---EVAIVGPIHPGMEL 1891

Query: 1125 GCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGI 1184
              + A D D    +NY+   GN    + + P TG + +         L   + +  SDG+
Sbjct: 1892 LMVRASDED--SEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLG--LSRKLTIRASDGL 1947

Query: 1185 HSVTAFCTLRVTIITDDML 1203
            +  TA   + +T + D  L
Sbjct: 1948 YQDTALVKISLTQVLDKSL 1966



 Score =  286 bits (733), Expect = 2e-76
 Identities = 255/969 (26%), Positives = 416/969 (42%), Gaps = 82/969 (8%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +F   +Y+ ++ +    GT +LQ+ A     G    V Y    L    S G+F I++  G
Sbjct: 1554 RFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHY---SLLKGNSEGFFNINALLG 1610

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
             ++    LD+     H L VKA D  +P       + + V  ++  +P+F +SEY   + 
Sbjct: 1611 IITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIP 1670

Query: 364  ENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
            E++ VG  +L + A    S +   LR    G    VF +N  SG++ST+  LD E+ + Y
Sbjct: 1671 ESIPVGSPILLVSAMS-PSEVTYELRE---GNKDGVFSMNSYSGLISTQKKLDHEKISSY 1726

Query: 424  QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR--- 480
            QL +    +G N         V +++ DENDN P F +  +V Q+ E   L + ++    
Sbjct: 1727 QLKI----RGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNN 1782

Query: 481  ----VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKA 536
                + A+D D+  N+ + Y IL       F +    G L +++ +D+E +  +   +  
Sbjct: 1783 NPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYV 1842

Query: 537  QDGGRPPLI-NSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
             D G P L       V + V DVND+ P F    ++  ++  +  G  ++ ++A D DS 
Sbjct: 1843 HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSE 1902

Query: 596  ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVC----AELDREEVE 651
             N  +     D A T                     IH  +G I+V       L R+   
Sbjct: 1903 VNYSIKTGNADEAVT---------------------IHPVTGSISVLNPAFLGLSRKLTI 1941

Query: 652  HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA 711
              S G+            +  V I++  V D    F Q  Y   + E+     +++ L A
Sbjct: 1942 RASDGL---------YQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA 1992

Query: 712  RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG-TRS 770
            +    N  ++Y L  G          Q  G L T  +  D +Q+  + LAV   D  T  
Sbjct: 1993 QGNHLNDTLSYFLLNGTDMFHMV---QSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQ 2049

Query: 771  HTAHVLINVT--DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI 828
              A  L+ V+  D N + P F+   Y   + +    G  +  +SA DED G N  +TY  
Sbjct: 2050 RVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF 2109

Query: 829  QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDN 888
             +    FRIDP  G +      DY+    Y L ++A+D G P  S  +  E+L+   N +
Sbjct: 2110 AEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTP--SLQSEEEVLVTVRNKS 2167

Query: 889  APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNG-RLLYTFQGGDDGDGDFYIEPTS 947
             P F   +Y+  + E+    T IL   A      P G RL+Y     ++    F  +  +
Sbjct: 2168 NPLFQSPYYKVRVPENITLYTPILHTQA----RSPEGLRLIYNIV-EEEPLMLFTTDFKT 2222

Query: 948  GVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELF 1007
            GV+     LD E+   +     A D    +   A+VE+ V   D+NDN P F +      
Sbjct: 2223 GVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVE--DVNDNPPTFSQLVYTTS 2280

Query: 1008 VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE--GDMRHFFQLDLLNGDLRAMVELDFE 1065
            + E  P  + V ++ A+D D G N  + YQIVE   D+  FFQ++   G++  + ELD+E
Sbjct: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYE 2340

Query: 1066 VRREYVLVVQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG 1122
             ++ + + V+A      PL     V + + D NDNPP     Q     Y  N S     G
Sbjct: 2341 AQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQ-----YEANVSELATCG 2395

Query: 1123 -VIGCIPAHDPDVSDS--LNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVS 1179
             ++  + A DPD  D+  L Y  + GN+ R   ++ ++G + +      +      + V 
Sbjct: 2396 HLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVG 2455

Query: 1180 VSDGIHSVT 1188
             SDG+   T
Sbjct: 2456 ASDGVFRAT 2464



 Score =  279 bits (714), Expect = 3e-74
 Identities = 264/1044 (25%), Positives = 471/1044 (45%), Gaps = 88/1044 (8%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +FP   YQ+ + E+   GT I +L        +  RV Y +    ++     F +   TG
Sbjct: 819  RFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK-----FSLHPLTG 873

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRS--ATTYITVLVKDTNDHSPVFEQSEYRER 361
             +     LDRE++  ++L+V+A D  +      + T + + ++D ND+SP       R +
Sbjct: 874  ELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLK 933

Query: 362  VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAA 421
            V E+L  G  +  + ASD D      +RY ++ GA   F+++  +G +     LD E  A
Sbjct: 934  VPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRA 993

Query: 422  EYQLLVEANDQGRNPGPLSATATVYIEV----EDENDNYPQFSEQNYVVQVPEDVGLNTA 477
             Y L + A+D GR   PL+     ++EV     +EN + P F+   +  QV E+    T 
Sbjct: 994  GYNLSLWASDGGR---PLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQ 1050

Query: 478  VLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQ 537
            V+ V A D D G +  + Y + +G     F ++  +G++  + PLD E    Y L++ A 
Sbjct: 1051 VIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAV 1110

Query: 538  DGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597
            D G  PL +S   V ++V D NDN P    + F  ++ E+ P+G  V+ + A D DS   
Sbjct: 1111 DRGSVPL-SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSK 1169

Query: 598  ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGV 657
             +L + +  T+  ++G                F IH  +G ++   +LDRE  + +   V
Sbjct: 1170 GKLTFNI--TSGNYMGF---------------FMIHPVTGLLSTAQQLDRENKDEHILEV 1212

Query: 658  EAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGS--SVLTLQARDRD 715
              +D+G P + S++ V + +LDVNDN P+F+   + +RL E  +  S   V  L A D D
Sbjct: 1213 TVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLD 1272

Query: 716  --ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHT 772
               N  +TY +   +    F++    G     ++    +   +  +L + A+D G    +
Sbjct: 1273 EGLNGRVTYSIEDSD-EEAFSIDLVTG----VVSSSSTFTAGEYNILTIKATDSGQPPLS 1327

Query: 773  AHVLINVTDANTHRP-----VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYV 827
            A V +++      RP      F  ++Y+ +V E  PV   +  +S      G      + 
Sbjct: 1328 ASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE----GRPGLFWFN 1383

Query: 828  IQ--DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI-LILD 884
            I   D    F I+  +G++     LD   +  Y LT+   D     ++  T + I +I +
Sbjct: 1384 ISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG---SRTIATQVHIFMIAN 1440

Query: 885  ANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGD--FY 942
             N + PQFL   Y+  + +D  P   +L+V A D+D G +  L+YT  G  D      F 
Sbjct: 1441 INHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSASLFQ 1498

Query: 943  IEPTSGVIRTQRRLD-RENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEK 1001
            ++P+SGV+ T  +LD     + + L  +  D+  P   +  V + + + D N + P F +
Sbjct: 1499 LDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRN-FVWVTIHVEDGNLHPPRFTQ 1557

Query: 1002 DELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVE 1061
               E  V +    G+ + ++RA D D G NA++ Y +++G+   FF ++ L G +    +
Sbjct: 1558 LHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQK 1617

Query: 1062 LDFEVRREYVLVVQAT---SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNS 1118
            LD      + L V+A    S      ATV I +   + + P+        + Y      S
Sbjct: 1618 LDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSK-----SEYFVEIPES 1672

Query: 1119 FPTG-VIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALME 1177
             P G  I  + A  P     + Y   +GN+  +  ++  +G +   + LD+ +     ++
Sbjct: 1673 IPVGSPILLVSAMSP---SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLK 1729

Query: 1178 VSVSDGIHSVTAFCTLRVTI-ITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLS 1236
            +    G +   AF  + V + I D+     + ++   + Q    +PL ++ ++       
Sbjct: 1730 IR---GSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMD------- 1779

Query: 1237 TTKDDVFVFNVQNDTDVSSNILNV 1260
               ++ FV +  +D+D  +N L V
Sbjct: 1780 -KNNNPFVIHA-SDSDKEANSLLV 1801



 Score =  276 bits (707), Expect = 2e-73
 Identities = 244/912 (26%), Positives = 415/912 (45%), Gaps = 72/912 (7%)

Query: 274  EGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTP-- 331
            + ++E  S  +  + +  +  +F+ID + G ++  S +D E+  +    V   D  +P  
Sbjct: 1791 DSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVL 1850

Query: 332  --PRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLR 389
              PR A   + + V+D ND  P F +  Y   +   +  G E+L +RASD DS +N +++
Sbjct: 1851 FAPRPAQ--VIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIK 1908

Query: 390  YRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEV 449
                G A +   ++  +G +S   +         +L + A+D     G    TA V I +
Sbjct: 1909 ---TGNADEAVTIHPVTGSIS--VLNPAFLGLSRKLTIRASD-----GLYQDTALVKISL 1958

Query: 450  EDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYL 509
                D   QF +  Y   V E++    A++ + A  +    N  + Y +L+G     F++
Sbjct: 1959 TQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNHLNDTLSYFLLNG--TDMFHM 2014

Query: 510  HSLSGILDVIN-PLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS 568
               +G+L       D E    + L+++ +D   P  + + G+V V + DVNDN P F   
Sbjct: 2015 VQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRV-AQGLVRVSIEDVNDNPPKFKHL 2073

Query: 569  PFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDF 628
            P+   + +    G  +  + A D D G N  + Y   +  +                   
Sbjct: 2074 PYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTY------------------ 2115

Query: 629  PFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFT 688
             F+I    G I++    D + +  Y   V A D G+P + S   V +TV   N ++P+F 
Sbjct: 2116 -FRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR--NKSNPLFQ 2172

Query: 689  QPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLAL 748
             P Y++R+ E+  + + +L  QAR  +   +I Y +        F    +   G++T+  
Sbjct: 2173 SPYYKVRVPENITLYTPILHTQARSPEGLRLI-YNIVEEEPLMLFTTDFKT--GVLTVTG 2229

Query: 749  PLDYKQEQQYVLAVTASD---GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVG 805
            PLDY+ + ++V  V A+D   G+ S  A V + V D N + P F    YT S+SE  P  
Sbjct: 2230 PLDYESKTKHVFTVRATDTALGSFSE-ATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQ 2288

Query: 806  TSIATLSANDEDTGENARITYVI----QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLT 861
            T +  L A+D+D+G N  ++Y I     D    F+I+  +G M T+ ELDYE Q  + + 
Sbjct: 2289 TPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVK 2348

Query: 862  IMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDS 921
            + A D G P  +  T + + + D NDN P+F    Y+ ++ E A     +L+V A D DS
Sbjct: 2349 VRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDS 2408

Query: 922  GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981
                RL Y    G+  D  F+I  +SG+I       +   + YNL   A D        A
Sbjct: 2409 RDTSRLEYLILSGNQ-DRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASD----GVFRA 2463

Query: 982  SVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEG 1041
            +V + +   + N  +P F++   E  + EN  VG+ V  + A D D GP   I Y I+  
Sbjct: 2464 TVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINK 2523

Query: 1042 DMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATS---APLVSRATVHILLVDQNDNP 1098
                 F ++  NG +  + +LD E   E V+ ++  +      V+  TV I+L D+NDNP
Sbjct: 2524 LASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNP 2582

Query: 1099 PVLPDFQILFNNY-VTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNE---LRLLLLD 1154
            P     Q   + Y V+ +SN      +  + A+D D   + + T+    E     ++ ++
Sbjct: 2583 P-----QFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEIN 2637

Query: 1155 PATGELQLSRDL 1166
            P TG +++   L
Sbjct: 2638 PVTGVVKVKDSL 2649



 Score =  265 bits (678), Expect = 4e-70
 Identities = 268/997 (26%), Positives = 425/997 (42%), Gaps = 122/997 (12%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F  P+Y+V + E+ P  + I ++ A     G+     Y     F+ RS   F I   +G 
Sbjct: 148  FSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYY----AFNTRSE-MFAIHPTSGV 202

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTND--HSPVFEQSEYRE 360
            V+    L+   +  H L+V AVD          +  +  LV         P    S    
Sbjct: 203  VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVT 262

Query: 361  RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-------AWDVFQLNESSGVVSTRA 413
                N    Y  + + A+   + + +     V+GG       A   +  +    +VS + 
Sbjct: 263  PPDSNDGTTYATVLVDANSSGAEVES---VEVVGGDPGKHFKAIKSYARSNEFSLVSVKD 319

Query: 414  VLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVG 473
            +   E    + L ++A       GP   +      +     +  +F +  Y VQ+ E   
Sbjct: 320  INWMEYLHGFNLSLQARS---GSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSP 376

Query: 474  LNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
              + V+ V+ T         +  S  S NV   F L++ +G++     +DF D   Y L 
Sbjct: 377  PGSRVVMVRVTPAFPNLQYVLKPS--SENVG--FKLNARTGLITTTKLMDFHDRAHYQLH 432

Query: 534  IKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDAD 593
            I+   G       +S VV + ++D N++ P+F  S +  T+ EN+P G  V+ + A D D
Sbjct: 433  IRTSPG------QASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRD 486

Query: 594  SGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEH- 652
             GEN  + Y +            AGPK        PF I    G I+    +D E ++  
Sbjct: 487  HGENGYVTYSI------------AGPKA------LPFSIDPYLGIISTSKPMDYELMKRI 528

Query: 653  YSFGVEAVDHGSP-PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA 711
            Y+F V A D GSP       S+ + + ++NDN P+F +      + +D  VG S++T+ A
Sbjct: 529  YTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSA 588

Query: 712  RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALP---LDYKQEQQYVLAVTASDGT 768
             D D    + Y++  GN    F L+     G+I+L  P   L   Q   Y L +TASDG 
Sbjct: 589  IDVDELQNLKYEIVSGNELEYFDLN--HFSGVISLKRPFINLTAGQPTSYSLKITASDG- 645

Query: 769  RSHTAHVLINVT---DANTHRPV------------------------------------F 789
            +++ +   +N+T   D +   PV                                    +
Sbjct: 646  KNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTY 705

Query: 790  QSSHYT----------VSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRI 837
            Q +HYT          + V E  P+ T +A L+A D D G N ++ YVI D   +  F I
Sbjct: 706  QINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDI 765

Query: 838  DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFY 897
            + ++G +     LDYE    Y L +   D G PQKS    L + + D NDNAP+F    Y
Sbjct: 766  ELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGY 825

Query: 898  QGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD 957
            Q +I ED    T+I +++  D DS  NGR+ YT     +    F + P +G +     LD
Sbjct: 826  QLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTE---KFSLHPLTGELVVTGHLD 882

Query: 958  RENVAVYNLWALAVDRGSP-TPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGS 1016
            RE+   Y L   A D+ S    L +  ++ +T+ D+NDN+P    +   L V E+ P G+
Sbjct: 883  RESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGT 942

Query: 1017 VVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA 1076
            V+  + A+DPD GP  ++ Y +++G     F++DL+ G L    ELDFE R  Y L + A
Sbjct: 943  VLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWA 1001

Query: 1077 TSA--PLVSRATVH--ILLVDQNDN--PPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAH 1130
            +    PL  R   H  ++++D N+N  PP    F  +    V   S S    ++      
Sbjct: 1002 SDGGRPLARRTLCHVEVIVLDVNENLHPPHFASF--VHQGQVQENSPSGTQVIVVAAQDD 1059

Query: 1131 DPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLD 1167
            D  +   L Y    G  L    ++  TG +Q    LD
Sbjct: 1060 DSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLD 1096



 Score =  253 bits (646), Expect = 2e-66
 Identities = 245/931 (26%), Positives = 411/931 (44%), Gaps = 76/931 (8%)

Query: 274  EGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPR 333
            EG   RV+Y +E   +E     F ID  TG VS+ S       E ++L +KA D   PP 
Sbjct: 1273 EGLNGRVTYSIEDSDEEA----FSIDLVTGVVSSSSTFT--AGEYNILTIKATDSGQPPL 1326

Query: 334  SATTYITVLVKDTNDHSPV---FEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRY 390
            SA+  + +        S +   F+++ Y   V E   V + V  I    R      N+  
Sbjct: 1327 SASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLFWFNIS- 1385

Query: 391  RVLGGAWDV-FQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEV 449
               GG  D+ F + +++G +     LD    + Y L VE  D  R      AT      +
Sbjct: 1386 ---GGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRT----IATQVHIFMI 1438

Query: 450  EDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNA--AIHYSILSGNVAGQF 507
             + N + PQF E  Y V+VP+D      +LRVQA D+D+G++    IH S   G+ A  F
Sbjct: 1439 ANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGS-ASLF 1497

Query: 508  YLHSLSGILDVINPLDF-EDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
             L   SG+L  +  LD      +++L++  +D    P+  +   V++ V D N + P F 
Sbjct: 1498 QLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQ-EIPIKRNFVWVTIHVEDGNLHPPRFT 1556

Query: 567  SSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTP 626
               ++A+V + +  G  ++ ++A+DAD G NA +HY L       L G S G        
Sbjct: 1557 QLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSL-------LKGNSEGF------- 1602

Query: 627  DFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPV 686
               F I+   G IT+  +LD+     ++  V+A D GSP      +V I V   + + P+
Sbjct: 1603 ---FNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPI 1659

Query: 687  FTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITL 746
            F++  Y + + E   VGS +L + A    + S +TY+L  GN    F+++S    GLI+ 
Sbjct: 1660 FSKSEYFVEIPESIPVGSPILLVSAM---SPSEVTYELREGNKDGVFSMNSY--SGLIST 1714

Query: 747  ALPLDYKQEQQYVLAVTASDGTRSHT-AHVLINVTDANTHRPVFQSSHYTVSVSEDRPVG 805
               LD+++   Y L +  S+   + T   V++++ D N + P+F  S +   +SE  P+ 
Sbjct: 1715 QKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY 1774

Query: 806  TSIA-------TLSANDEDTGENARITYVIQDP--VPQFRIDPDSGTMYTMMELDYENQV 856
            + I         + A+D D   N+ + Y I +P  +  F+IDP  GT+  + E+DYE+  
Sbjct: 1775 SMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMP 1834

Query: 857  AYTLTIMAQDNGIPQKSDTTTLEILI--LDANDNAPQFLWDFYQGSIFEDAPPSTSILQV 914
            ++   +   D G P        +++I   D ND+ P+F    Y+ +I     P   +L V
Sbjct: 1835 SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMV 1894

Query: 915  SATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRG 974
             A+D DS  N    Y+ + G+  D    I P +G I         N A   L      R 
Sbjct: 1895 RASDEDSEVN----YSIKTGN-ADEAVTIHPVTGSISVL------NPAFLGLSRKLTIRA 1943

Query: 975  SPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQI 1034
            S      +  +++++  + D +  F++D     V+EN      +  + A       N  +
Sbjct: 1944 SDGLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQG--NHLNDTL 2001

Query: 1035 MYQIVEG-DMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL-VSRATVHILLV 1092
             Y ++ G DM H  Q   +        + + +   E  + V+    P  V++  V + + 
Sbjct: 2002 SYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIE 2061

Query: 1093 DQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLL 1152
            D NDNPP           Y   +  + P  V+  + A D D+  +   T+    +     
Sbjct: 2062 DVNDNPPKFKHLPY----YTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFR 2117

Query: 1153 LDPATGELQLSRDLDNNRPLEALMEVSVSDG 1183
            +DP  G++ L +  D     +  ++V   DG
Sbjct: 2118 IDPYLGDISLKKPFDYQALNKYHLKVIARDG 2148



 Score =  221 bits (564), Expect = 6e-57
 Identities = 240/973 (24%), Positives = 406/973 (41%), Gaps = 121/973 (12%)

Query: 306  STDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVREN 365
            S  ++L+RE ++++ L ++A +  T    A T + V + D ND  P+F    YR  + E+
Sbjct: 102  SNTALLNREVRDSYTLIIQATE-KTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISED 160

Query: 366  LEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQL 425
            + +   +  + A+D D   NA   Y       ++F ++ +SGVV+    L+     +++L
Sbjct: 161  MPLKSPICKVTATDADLGQNAEF-YYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHEL 219

Query: 426  LVEANDQGR---NPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ 482
             V A D+ R         + A + + VE      P  +    VV  P D    T    V 
Sbjct: 220  QVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIAS---VVVTPPDSNDGTTYATVL 276

Query: 483  ATDRDQGQNAAIHYSILSGNVAGQF-----YLHSLSGILDVINPLDF-EDVQKYSLSIKA 536
                  G        ++ G+    F     Y  S    L  +  +++ E +  ++LS++A
Sbjct: 277  VDANSSGAEVE-SVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQA 335

Query: 537  QDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE 596
            + G  P     S +    +     +   F  + ++  + E  P G  VV ++   A    
Sbjct: 336  RSGSGPYFY--SQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA---- 389

Query: 597  NARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFG 656
               L Y L  ++                  +  F+++  +G IT    +D  +  HY   
Sbjct: 390  FPNLQYVLKPSSE-----------------NVGFKLNARTGLITTTKLMDFHDRAHYQLH 432

Query: 657  VEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD- 715
            +      + P  +ST V I ++D N++ P+F + +Y+  L+E+   G+SVL + A DRD 
Sbjct: 433  IR-----TSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDH 487

Query: 716  -ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK-QEQQYVLAVTASDG----TR 769
              N  +TY + G         S     G+I+ + P+DY+  ++ Y   V ASD      R
Sbjct: 488  GENGYVTYSIAGPKA---LPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRR 544

Query: 770  SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
                 + + + + N ++P+F+  + T S+ +D PVG SI T+SA D D  +N +   V  
Sbjct: 545  EKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSG 604

Query: 830  DPVPQFRIDPDSGTM---YTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILIL--- 883
            + +  F ++  SG +      + L      +Y+L I A D      +  TTL I ++   
Sbjct: 605  NELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG--KNYASPTTLNITVVKDP 662

Query: 884  -------------------------------------------DANDNAPQFLWDFYQG- 899
                                                         N   PQF   F Q  
Sbjct: 663  HFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSI 722

Query: 900  SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRE 959
             + E  P +T + +++ATD D+G NG+L+Y    G++ +G F IE  +G++     LD E
Sbjct: 723  DVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNE-EGCFDIELETGLLTVAAPLDYE 781

Query: 960  NVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVA 1019
                Y L     D G+P   S  + + V + D NDNAP F     +L + E+  VG+ +A
Sbjct: 782  ATNFYILNVTVYDLGTPQKSSWKL-LTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIA 840

Query: 1020 KIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSA 1079
            ++   D D   N ++ Y ++    +  F L  L G+L     LD E    Y+L V+A   
Sbjct: 841  ELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLDRESEPRYILKVEARDQ 898

Query: 1080 P-----LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDV 1134
            P     L S   + I L D NDN P      I  +N +    +  P  V+  + A DPD+
Sbjct: 899  PSKGHQLFSVTDLIITLEDVNDNSPQC----ITEHNRLKVPEDLPPGTVLTFLDASDPDL 954

Query: 1135 --SDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCT 1192
              +  + Y  + G       +D  TG L L R+LD  R     + +  SDG   +     
Sbjct: 955  GPAGEVRYVLMDGAH-GTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTL 1013

Query: 1193 LRVTIITDDMLTN 1205
              V +I  D+  N
Sbjct: 1014 CHVEVIVLDVNEN 1026



 Score =  209 bits (532), Expect = 3e-53
 Identities = 232/869 (26%), Positives = 363/869 (41%), Gaps = 114/869 (13%)

Query: 388  LRYRVLGGAWDVFQLNESSGVV-------------STRAVLDREEAAEYQLLVEANDQGR 434
            +RYR++ G  DV  + ++   V             S  A+L+RE    Y L+++A ++  
Sbjct: 69   VRYRIISG--DVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTL 126

Query: 435  NPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAI 494
                L A   V + + D+ND  P FS  +Y V + ED+ L + + +V ATD D GQNA  
Sbjct: 127  E---LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEF 183

Query: 495  HYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQ 554
            +Y+      +  F +H  SG++ V   L+     K+ L + A D  R  +   +G  S+ 
Sbjct: 184  YYAF--NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMR-KISEGNGFGSLA 240

Query: 555  VLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGG 614
             L V+  EP     P  A+V+   P          V  D+  +        +  S  + G
Sbjct: 241  ALVVH-VEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSG------AEVESVEVVG 293

Query: 615  GSAGP-----KNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
            G  G      K+ A + +F         W+        E +  ++  ++A   GS P   
Sbjct: 294  GDPGKHFKAIKSYARSNEFSLVSVKDINWM--------EYLHGFNLSLQA-RSGSGPYFY 344

Query: 670  STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNT 729
            S      +     +   F +  Y ++L+E +  GS V+ ++      N  + Y L   + 
Sbjct: 345  SQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN--LQYVLKPSSE 402

Query: 730  RNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVF 789
               F L+++   GLIT    +D+     Y L +  S G  S    V+I++ D N H P+F
Sbjct: 403  NVGFKLNART--GLITTTKLMDFHDRAHYQLHIRTSPGQASTV--VVIDIVDCNNHAPLF 458

Query: 790  QSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDP-VPQFRIDPDSGTMYTMM 848
              S Y  ++ E+ P GTS+  ++A D D GEN  +TY I  P    F IDP  G + T  
Sbjct: 459  NRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSK 518

Query: 849  ELDYE-NQVAYTLTIMAQDNGIP-QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAP 906
             +DYE  +  YT  + A D G P ++    ++ + + + NDN P F      GSI +D P
Sbjct: 519  PMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWP 578

Query: 907  PSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR---RLDRENVAV 963
               SI+ +SA D D   N  L Y    G++ +  F +   SGVI  +R    L       
Sbjct: 579  VGKSIMTMSAIDVDELQN--LKYEIVSGNELE-YFDLNHFSGVISLKRPFINLTAGQPTS 635

Query: 964  YNLWALAVD---RGSPTPLSASV------EIQVT-------------------------- 988
            Y+L   A D     SPT L+ +V      E+ VT                          
Sbjct: 636  YSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESS 695

Query: 989  --------ILDINDNAPMFEKD-ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
                       IN   P FE      + V E+ P+ + +A++ A DPD G N +++Y I 
Sbjct: 696  DEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIA 755

Query: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLV---DQND 1096
            +G+    F ++L  G L     LD+E    Y+L V         +++  +L V   D ND
Sbjct: 756  DGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWND 815

Query: 1097 NPPVLPDFQILFNNYVTNKSNSFPTG-VIGCIPAHDPDVSDS--LNYTFVQGNELRLLLL 1153
            N P  P        Y    S     G  I  +   D D  D+  + YT +   E     L
Sbjct: 816  NAPRFPP-----GGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTE--KFSL 868

Query: 1154 DPATGELQLSRDLDNNRPLEALMEVSVSD 1182
             P TGEL ++  LD       +++V   D
Sbjct: 869  HPLTGELVVTGHLDRESEPRYILKVEARD 897



 Score =  157 bits (397), Expect = 2e-37
 Identities = 191/766 (24%), Positives = 320/766 (41%), Gaps = 115/766 (15%)

Query: 493  AIHYSILSGNVAGQF----YLHSLSGILDVINP------LDFEDVQKYSLSIKAQDGGRP 542
            A+ Y I+SG+VA  F    Y+      L +         L+ E    Y+L I+A +  + 
Sbjct: 68   AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATE--KT 125

Query: 543  PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHY 602
              + +   V V +LD ND +P+F    ++ T+ E++PL  P+  + A DAD G+NA  +Y
Sbjct: 126  LELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYY 185

Query: 603  RLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDH 662
               +T S                    F IH +SG +TV  +L+      +   V AVD 
Sbjct: 186  AF-NTRSEM------------------FAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDR 226

Query: 663  GSPPMSSSTSVSITVLDVNDNDPVFTQPTYE--LRLNEDAAVGSSVLTLQARDRDANS-- 718
                   +   S+  L V+    +   P     +    D+  G++  T+     DANS  
Sbjct: 227  MRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLV---DANSSG 283

Query: 719  --VITYQLTGGNTRNRF-ALSSQRGGGLITLALPLDYKQEQQ---YVLAVTASDGTRSHT 772
              V + ++ GG+    F A+ S       +L    D    +    + L++ A  G+  + 
Sbjct: 284  AEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYF 343

Query: 773  AHVL--INVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD 830
               +   ++  +      F+ + Y V +SE  P G+ +  +      T     + YV++ 
Sbjct: 344  YSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRV----TPAFPNLQYVLKP 399

Query: 831  PVPQ--FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDN 888
                  F+++  +G + T   +D+ ++  Y L I            +T + I I+D N++
Sbjct: 400  SSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPG-----QASTVVVIDIVDCNNH 454

Query: 889  APQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG 948
            AP F    Y G++ E+ PP TS+L V+ATDRD G NG + Y+  G       F I+P  G
Sbjct: 455  APLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAG--PKALPFSIDPYLG 512

Query: 949  VIRTQRRLDRENV-AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELF 1007
            +I T + +D E +  +Y     A D GSP      V I + + ++NDN PMFE+      
Sbjct: 513  IISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGS 572

Query: 1008 VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDL---RAMVELDF 1064
            + ++ PVG  +  + A D DE  N  + Y+IV G+   +F L+  +G +   R  + L  
Sbjct: 573  IRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTA 630

Query: 1065 EVRREYVLVVQATSAP-LVSRATVHILLV-DQNDNPPV---------------------- 1100
                 Y L + A+      S  T++I +V D +   PV                      
Sbjct: 631  GQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQ 690

Query: 1101 -----------LPDFQILFNNYVTNKSNSFPTGV-----------IGCIPAHDPDV--SD 1136
                       L  +QI  N+Y     + FP  +           +  + A DPD   + 
Sbjct: 691  NQESSDEEFTSLSTYQI--NHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNG 748

Query: 1137 SLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
             L Y    GNE     ++  TG L ++  LD       ++ V+V D
Sbjct: 749  KLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYD 794



 Score = 59.7 bits (143), Expect = 4e-08
 Identities = 26/67 (38%), Positives = 36/67 (53%), Gaps = 2/67 (2%)

Query: 1346 GLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSG 1405
            G  C+CPP F+G +CE   + C   PC   G C     G +C C   +TG+ CE++AR  
Sbjct: 3969 GYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARG- 4027

Query: 1406 RCANGVC 1412
             C+ G C
Sbjct: 4028 -CSEGHC 4033



 Score = 55.8 bits (133), Expect = 6e-07
 Identities = 57/227 (25%), Positives = 97/227 (42%), Gaps = 31/227 (13%)

Query: 1489 HDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHG 1548
            H    L+ +  Q  L F+    T +V+ K+ SGV    +H +   Y N  +  H+     
Sbjct: 3795 HIHFYLKTLQPQAILLFT--NETASVSLKLASGVPQLEYHCLGGFYGNLSSQRHV----- 3847

Query: 1549 PSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPE 1608
             +  +   + V++ D ++ +     +GN S        G +    L    LLGG+  L  
Sbjct: 3848 -NDHEWHSILVEEMDASIRLMVDS-MGNTSLVVPENCRGLRPERHL----LLGGLILLHS 3901

Query: 1609 DFPVHNRQFVGCMRNLSVDGKNVDM-------AGFIANNGTREGCAARRNFCDGRRCQNG 1661
               V ++ F GC+  + V+ + +D+       AG +      + C    ++C    C NG
Sbjct: 3902 SSNV-SQGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQ-CCLHSDYCSQNTCLNG 3959

Query: 1662 GTCVNRWNM---YLCECPLRFGGKNCEQAMPH----PQLFSGESVVS 1701
            G C   W     Y+C+CP +F GK+CEQ   +    P L  G  ++S
Sbjct: 3960 GKC--SWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILS 4004



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 67/290 (23%), Positives = 111/290 (38%), Gaps = 43/290 (14%)

Query: 1694 FSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVS 1753
            FSG+S V +       +  W++    +T +  ++L+        S +L      L++   
Sbjct: 3778 FSGQSYVRY---RAPAARNWHIHFYLKTLQPQAILLFTNETASVSLKLASGVPQLEYHCL 3834

Query: 1754 HGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGML 1813
             G       + S   V D EWH +L+E        EM   + + +D  M      +    
Sbjct: 3835 GG---FYGNLSSQRHVNDHEWHSILVE--------EMDASIRLMVD-SMGNTSLVVPENC 3882

Query: 1814 PGL-TVRSVVVGG--ASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMNNA--LKVRVKD 1868
             GL   R +++GG        +V +GF GC+  V +     ++       A  L+ +   
Sbjct: 3883 RGLRPERHLLLGGLILLHSSSNVSQGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALT 3942

Query: 1869 GCDV-DDPCTSSPCPPNSRCHDAW---EDYSCVCDKGYLGINCV---DACHLNPCENMGA 1921
             C +  D C+ + C    +C  +W     Y C C   + G +C    + C   PC   G 
Sbjct: 3943 QCCLHSDYCSQNTCLNGGKC--SWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCLEGGT 4000

Query: 1922 CVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHCAVS 1971
            C+    SP+G  C C   + G  CE +      RG      C   HC V+
Sbjct: 4001 CIL---SPKGASCNCPHPYTGDRCEME-----ARG------CSEGHCLVT 4036



 Score = 32.3 bits (72), Expect = 7.3
 Identities = 14/38 (36%), Positives = 19/38 (50%), Gaps = 1/38 (2%)

Query: 1404 SGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYCE 1441
            S  C+   C NGG C      G+ C CPP ++   +CE
Sbjct: 3948 SDYCSQNTCLNGGKCSWTHGAGYVCKCPP-QFSGKHCE 3984


>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
          Length = 2916

 Score =  360 bits (923), Expect = 2e-98
 Identities = 298/973 (30%), Positives = 455/973 (46%), Gaps = 78/973 (8%)

Query: 242  SLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
            S  FP   YQ ++ E+   GT++L L A    EG   +  Y+   L DE S G F ID  
Sbjct: 1475 SPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYF---LTDEAS-GAFTIDPM 1530

Query: 302  TGAVSTDSVLDRETKETHVLRVKAVDYSTP-PRSATTYITVLVKDTNDHSPVFEQSEYRE 360
            +G + T + LDRE +  H     A D S    RS T  I V V D ND+ PV EQ+ +  
Sbjct: 1531 SGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590

Query: 361  RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEA 420
             +          + +RA D D   N  + +        +F +++ +G +       +  +
Sbjct: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVFS-FAETQSMFSIDKYTGEIQ----FQQNPS 1645

Query: 421  AEY---QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTA 477
            +EY    L ++  DQG      +    +++E ED   +   FS   Y   V E+    T+
Sbjct: 1646 SEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKIS---FSHHLYKGLVTENCEAGTS 1702

Query: 478  VLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP--LDFEDVQKYSLSIK 535
            ++ V+A   D  Q+ ++ YSI SGN  G   L S SG L V  P  LDFE   +  L + 
Sbjct: 1703 IVTVKAFAPDSIQD-SMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVL 1761

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595
            A+  G          V+V + D NDN P F  S +QA+V E+      V+ + A D DSG
Sbjct: 1762 AESSGHRAYCK----VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSG 1817

Query: 596  ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSF 655
             N  + Y ++           +G +  A      FQI   SG IT  A LD E    YS 
Sbjct: 1818 LNGLIEYSIL-----------SGNQEEA------FQIDALSGVITTKAILDYELTSSYSL 1860

Query: 656  GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
             V+A D G P +S++T + + V D+NDN P F  P+  + + ED+  G  V  +   D D
Sbjct: 1861 IVQATDKGMPRLSNTTVIKVQVTDINDNAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVD 1919

Query: 716  ANSVITYQLT-GGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAH 774
             NS   +      N   +FA+   +  G++ L   LD+++  +Y L +  SD        
Sbjct: 1920 LNSAFIFSFAKESNPGTKFAI--DQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGA 1977

Query: 775  VLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ 834
            +++ V D N + PVF    Y V+V E  PVG S+ TLSA D ++ EN  I+Y I     +
Sbjct: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKE 2035

Query: 835  FRIDPDSGTMYTMMELDYENQVAYT-LTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
            F IDP +GT++T+  +   + ++ T   + A D G P     T +EI I D N+ AP+F 
Sbjct: 2036 FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFT 2095

Query: 894  WDFYQGSIFEDAPPSTSILQVSATDRD-SGPNGRLLYTFQGGDDGDGDFYIE-------- 944
               Y  S+ EDA   ++++  S  D D +  N  + Y+   G +   +F++E        
Sbjct: 2096 VKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISG-NSQNNFHVETKFFHSEY 2154

Query: 945  --PTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKD 1002
                 G +     LDRE  A + L  LA D G P PLS++  I + +LD+NDN P F   
Sbjct: 2155 PYKQVGYLVLLHSLDREASASHELVILASDSGCP-PLSSTAVISIQVLDVNDNPPNFSSL 2213

Query: 1003 ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVEL 1062
                 V+E+ P+GS +  + AND D G +A+I+Y I+ G+ +  F L+   G L  +  L
Sbjct: 2214 SYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPL 2273

Query: 1063 DFEVRREYVLVVQATSAPL--VSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFP 1120
            D+E   ++ L VQA+ A     S A V + ++D ND+ P     Q +F+++      + P
Sbjct: 2274 DYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAP-----QFMFSSFSCIVPENLP 2328

Query: 1121 -TGVIGCIPAHDPDVS--DSLNYTFV--------QGNELRLLLLDPATGELQLSRDLDNN 1169
             +  I  I A D D      L Y+ V           +  L L+DP TG++   + LD  
Sbjct: 2329 ISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYE 2388

Query: 1170 RPLEALMEVSVSD 1182
               +  + V   D
Sbjct: 2389 NGNKYCLTVQAKD 2401



 Score =  354 bits (909), Expect = 6e-97
 Identities = 299/1004 (29%), Positives = 469/1004 (46%), Gaps = 84/1004 (8%)

Query: 248  PNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVST 307
            PN  V   E+   G+L+  + AH   EG   +V+Y    +        F +D ++G ++T
Sbjct: 1169 PNAHVK--EDVTVGSLVHHITAHDPDEGRNGKVTY---SILSGNENMTFMLDESSGLLTT 1223

Query: 308  DSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLE 367
               LD E K  H+L V A+D  TP  S++  +TV V D ND +PVF+Q  Y   V+EN  
Sbjct: 1224 TCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQN 1283

Query: 368  VGYEVLTIRASDRDSPINANLRYRVLGGA-WDVFQLNESSGVVSTRAVLDREEAAEYQLL 426
             G  V  + A DRDS +N+ L++ ++ GA +++F++N  +G V T  +LDRE    + L 
Sbjct: 1284 PGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLR 1343

Query: 427  VEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDR 486
            V   D G     LS+T T+   VEDEND+ P+F   +Y ++V E+      V  V A+D 
Sbjct: 1344 VLVRDGGF--PSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQE-PEVVYTVLASDM 1400

Query: 487  DQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLIN 546
            D G N A+ Y I+ GN    F ++ +SG L     LD E +  ++L I   D G PP   
Sbjct: 1401 DAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--R 1458

Query: 547  SSGV-VSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLV 605
            SS + + V+VLD ND+ P F +  +Q++V E+  +G  V+ + AVD D G N +  Y L 
Sbjct: 1459 SSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT 1518

Query: 606  DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVD---H 662
            D AS                    F I   SG +     LDRE    ++F   A D    
Sbjct: 1519 DEASG------------------AFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQ 1560

Query: 663  GSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITY 722
            GS   S++  + + V DVNDNDPV  Q  +++ L+ ++    + + ++A D D     T 
Sbjct: 1561 GS--RSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTV 1618

Query: 723  QLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYV-----LAVTASDGTRSHTAHVLI 777
              +   T++ F++    G       +        +Y      L VT        T  +L+
Sbjct: 1619 VFSFAETQSMFSIDKYTG------EIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLV 1672

Query: 778  NVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI----QDPVP 833
               +    +  F    Y   V+E+   GTSI T+ A   D+ +++ + Y I    +D V 
Sbjct: 1673 IHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDS-MKYSIFSGNEDGVL 1731

Query: 834  QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
                     T+     LD+E +    L ++A+ +G         + +LI D NDN+P F 
Sbjct: 1732 SLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSPCFE 1788

Query: 894  WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ 953
               YQ S+ E    +  ++QV ATD DSG NG + Y+   G+  +  F I+  SGVI T+
Sbjct: 1789 QSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEA-FQIDALSGVITTK 1847

Query: 954  RRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNP 1013
              LD E  + Y+L   A D+G P  LS +  I+V + DINDNAP F   E     E++ P
Sbjct: 1848 AILDYELTSSYSLIVQATDKGMPR-LSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP 1906

Query: 1014 VGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLV 1073
             G +V  +  +D D   +A I     E +    F +D   G +  +  LDFE   EY L+
Sbjct: 1907 -GVIVTHVSVHDVDLN-SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELL 1964

Query: 1074 VQATSAPLVSRATVHILLVDQNDNPPVL-PDFQILFNNYVTNKSNSFPTGV-IGCIPAHD 1131
            +Q + +   +   + + ++D NDNPPV   DF      Y      S P G  +  + A D
Sbjct: 1965 IQISDSVHYTEGALVVRVLDVNDNPPVFSQDF------YQVTVPESIPVGYSVLTLSATD 2018

Query: 1132 PDVSDSLNYTFVQGNE--------------LRLLLLDPATGELQLSRDLDNNRP-LEA-- 1174
             + +++++Y  +  ++                +LLLD  +    L    D   P L A  
Sbjct: 2019 LESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALT 2078

Query: 1175 LMEVSVSDGIHSVTAFCTLRVTI-ITDDMLTNSITVRLENMSQE 1217
            L+E+ + D  +    F      + +++D L  S  V   N+  +
Sbjct: 2079 LVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHD 2122



 Score =  333 bits (854), Expect = 2e-90
 Identities = 280/905 (30%), Positives = 412/905 (45%), Gaps = 73/905 (8%)

Query: 292  SRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSP 351
            ++  F ID  TG +        E      L++K  D   P R+ TT + V+  +  D   
Sbjct: 1625 TQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPART-TTGLLVIHMEGEDVKI 1682

Query: 352  VFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVS 410
             F    Y+  V EN E G  ++T++A   DS I  +++Y +  G  D V  L   SG ++
Sbjct: 1683 SFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLT 1741

Query: 411  TRA--VLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
             +    LD E   E QL+V A   G       A   V + ++DENDN P F +  Y   V
Sbjct: 1742 VKEPKFLDFEVRNEVQLIVLAESSGHR-----AYCKVAVLIQDENDNSPCFEQSIYQASV 1796

Query: 469  PEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQ 528
             E    N  V++V ATD D G N  I YSILSGN    F + +LSG++     LD+E   
Sbjct: 1797 SESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTS 1856

Query: 529  KYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQ 588
             YSL ++A D G P L N++ V+ VQV D+NDN P F+ S       +++P G  V H+ 
Sbjct: 1857 SYSLIVQATDKGMPRLSNTT-VIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHVS 1914

Query: 589  AVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE 648
              D D           +++A  F     A   NP       F I  ++G + +   LD E
Sbjct: 1915 VHDVD-----------LNSAFIF---SFAKESNPGTK----FAIDQNTGVVVLVKTLDFE 1956

Query: 649  EVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708
            E+  Y   ++  D       +  ++ + VLDVNDN PVF+Q  Y++ + E   VG SVLT
Sbjct: 1957 EMTEYELLIQISDSVH---YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLT 2013

Query: 709  LQARDRDANSVITYQLTGGNTRNRFALSSQRGGGL-ITLALPLDYKQEQQYVLAVTASDG 767
            L A D ++N  I+Y++   +    F++  + G    I+  L LD     Q++  V ASDG
Sbjct: 2014 LSATDLESNENISYRILSSS--KEFSIDPKNGTIFTISPVLLLDTISTTQFL--VEASDG 2069

Query: 768  ----TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDED-TGENA 822
                 R+ T  V I + D N + P F    Y +S+SED  VG+++ T S  D D T EN 
Sbjct: 2070 GNPDLRALTL-VEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENT 2128

Query: 823  RITYVIQDPVPQFRIDPDS------------GTMYTMMELDYENQVAYTLTIMAQDNGIP 870
             + Y I     Q     ++            G +  +  LD E   ++ L I+A D+G P
Sbjct: 2129 YVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCP 2188

Query: 871  QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYT 930
              S T  + I +LD NDN P F    Y   + E  P  + I  VSA DRD+G +  ++Y 
Sbjct: 2189 PLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYN 2248

Query: 931  FQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTIL 990
               G++  G FY+E  +GV+   + LD E +  + L   A D       S +V + V++L
Sbjct: 2249 IISGNE-KGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD-AEKKHFSFAV-VFVSVL 2305

Query: 991  DINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDM------- 1043
            D ND+AP F        V EN P+ S +  I A D D GP  ++ Y IV           
Sbjct: 2306 DDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSY 2365

Query: 1044 -RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA-TSAPLVSRATVHILLVDQNDNPPVL 1101
                F +D L GD+ A   LD+E   +Y L VQA       +   V + +   ++  P+ 
Sbjct: 2366 DHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIF 2425

Query: 1102 PDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQ 1161
               Q  F     NK       +IG + A D D        +  G       ++   G + 
Sbjct: 2426 TQDQYFFTLPEKNKDRQ----LIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIY 2481

Query: 1162 LSRDL 1166
            L R L
Sbjct: 2482 LIRAL 2486



 Score =  302 bits (774), Expect = 3e-81
 Identities = 278/1003 (27%), Positives = 436/1003 (43%), Gaps = 63/1003 (6%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +F  P Y   ++E+ P  + I  + A   +   E        G       G F I    G
Sbjct: 376  EFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLG----GKFSIHPRLG 431

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
             + T   LD ET+   VL V+A    + P  ++T + + V D ND+ P F ++    R+ 
Sbjct: 432  TIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRIS 490

Query: 364  ENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
            +    G  +   RA DRDS  N  +RY +      VF ++ + GV+     L   E  E 
Sbjct: 491  QTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQREL 550

Query: 424  QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQA 483
             L + A DQG +P       TV IE  + + ++  F    Y V+V E +   T +L+ QA
Sbjct: 551  TLTLRAEDQGVHPQAALLVLTVVIEKREHSPSW-TFEHLVYQVEVSESLSPMTQMLQTQA 609

Query: 484  TDRDQGQNAA-IHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP 542
                  + A+ + YS+     +  F +   +G + +    D+E  Q Y+  + A      
Sbjct: 610  HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 669

Query: 543  PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLEN-VPLGYPVVHIQAVDADSGENARLH 601
             L N S  V V+V D NDN P F+       V E+ VP G  +  I A+D DSG+N +L 
Sbjct: 670  FLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDSGKNGQLL 728

Query: 602  YRLVDTASTFLGGGSAGPKNPA------------PTPDFPFQIHN-------------SS 636
            Y L+     F    + GP                   DF F                   
Sbjct: 729  YFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGE 788

Query: 637  GWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQ--PTYEL 694
            G +     LDRE   H+   V   D GSPP +++ +V ++V D+NDN P F Q  P  EL
Sbjct: 789  GELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKEL 848

Query: 695  RLN--EDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPL 750
             +   E   V   V T+ A+D D   N+ +TY ++  ++ + F + +  G    T  L  
Sbjct: 849  HVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSY 908

Query: 751  DYKQEQQYVLAVTASD---GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTS 807
            DY+    Y ++V A+D         A V I V   +  R +   +   + + E+      
Sbjct: 909  DYR--PSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966

Query: 808  IATLSAND---EDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMA 864
            ++ + ++D   +        + V  D    F ID  +G ++   ELDYE    Y   ++ 
Sbjct: 967  MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVIT 1026

Query: 865  QDNGIP-QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRD-SG 922
             D+      S T  L I + D ND++P F  +    S+ E+ P  T +   +A D D S 
Sbjct: 1027 TDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSF 1086

Query: 923  PNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTP--LS 980
             N R+ Y  +  + G   F I P+ G + T  RLDRE++    L   A D+         
Sbjct: 1087 LNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL 1146

Query: 981  ASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE 1040
             S+  Q+ ILD+ND+ P F        V+E+  VGS+V  I A+DPDEG N ++ Y I+ 
Sbjct: 1147 RSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILS 1205

Query: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQAT---SAPLVSRATVHILLVDQNDN 1097
            G+    F LD  +G L     LD+E++ +++L V A    +  L S  T+ + ++D ND 
Sbjct: 1206 GNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDE 1265

Query: 1098 PPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDP 1155
             PV    Q L+   V  K N  P   +  + A D D  V+  L +  + G    L  ++ 
Sbjct: 1266 APVFK--QHLYEASV--KENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINS 1321

Query: 1156 ATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTAFCTLRVTI 1197
             TGE+  +  LD        + V V D G  S+++  T+  T+
Sbjct: 1322 DTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTV 1364



 Score =  290 bits (741), Expect = 2e-77
 Identities = 269/984 (27%), Positives = 428/984 (43%), Gaps = 74/984 (7%)

Query: 244  KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
            +F + +Y + + EN+    +   L +     G    V Y+   + D  +   F I+  +G
Sbjct: 1373 EFIVSSYDIEVLENQEPEVVYTVLASDMDA-GNNRAVEYH---IIDGNTDECFTINEMSG 1428

Query: 304  AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
             +ST   LDRE      L +   D   PPRS+  ++ V V D NDHSP F    Y+  VR
Sbjct: 1429 ELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVR 1488

Query: 364  ENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
            E+ EVG  VL + A D+D  +N    Y +   A   F ++  SG + T   LDRE  +++
Sbjct: 1489 EDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQH 1548

Query: 424  QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQA 483
                 A D     G  S T  + + V D NDN P   +  + V +  +   N   + V+A
Sbjct: 1549 TFSAVARDCSIQ-GSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRA 1607

Query: 484  TDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPP 543
             D D G N  + +S         F +   +G +        E    + L +K  D G P 
Sbjct: 1608 DDLDLGPNGTVVFSF--AETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPA 1664

Query: 544  LINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYR 603
               ++G++ +  ++  D +  F    ++  V EN   G  +V ++A   DS +++  +  
Sbjct: 1665 R-TTTGLLVIH-MEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKY-- 1720

Query: 604  LVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE--LDREEVEHYSFGVEAVD 661
                 S F G             D    + + SG +TV     LD E        V A  
Sbjct: 1721 -----SIFSG-----------NEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES 1764

Query: 662  HGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSV 719
             G     +   V++ + D NDN P F Q  Y+  ++E     + V+ + A D D+  N +
Sbjct: 1765 SGH---RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGL 1821

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD---GTRSHTAHVL 776
            I Y +  GN    F + +    G+IT    LDY+    Y L V A+D      S+T  + 
Sbjct: 1822 IEYSILSGNQEEAFQIDAL--SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIK 1879

Query: 777  INVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ-DPVPQF 835
            + VTD N + P F  S   V ++ED   G  +  +S +D D       ++  + +P  +F
Sbjct: 1880 VQVTDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKF 1938

Query: 836  RIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWD 895
             ID ++G +  +  LD+E    Y L I   D+          L + +LD NDN P F  D
Sbjct: 1939 AIDQNTGVVVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQD 1995

Query: 896  FYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRT-QR 954
            FYQ ++ E  P   S+L +SATD +S  N  + Y          +F I+P +G I T   
Sbjct: 1996 FYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSK---EFSIDPKNGTIFTISP 2050

Query: 955  RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPV 1014
             L  + ++       A D G+P  L A   +++ I D+N+ AP F      L + E+  V
Sbjct: 2051 VLLLDTISTTQFLVEASDGGNP-DLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALV 2109

Query: 1015 GSVVAKIRANDPD-EGPNAQIMYQIVEGDMRHFFQLDL----------LNGDLRAMVELD 1063
            GS +      D D    N  + Y I+ G+ ++ F ++             G L  +  LD
Sbjct: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169

Query: 1064 FEVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFP 1120
             E    + LV+ A+ +   PL S A + I ++D NDNP   P+F  L  +Y T+   S P
Sbjct: 2170 REASASHELVILASDSGCPPLSSTAVISIQVLDVNDNP---PNFSSL--SYHTHVKESTP 2224

Query: 1121 TGV-IGCIPAHDPDVSD--SLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALME 1177
             G  I  + A+D D      + Y  + GNE     L+  TG L L + LD  +  +  + 
Sbjct: 2225 LGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLT 2284

Query: 1178 VSVSDGIHSVTAFCTLRVTIITDD 1201
            V  SD      +F  + V+++ D+
Sbjct: 2285 VQASDAEKKHFSFAVVFVSVLDDN 2308



 Score =  244 bits (624), Expect = 7e-64
 Identities = 267/1043 (25%), Positives = 442/1043 (42%), Gaps = 135/1043 (12%)

Query: 285  EGLFDERSRGYFRIDSATGAVSTDSVLDRETKE-THVLRVKAVDYSTPPR---------- 333
            +G     +   FRID   G +     +DRE    T+ L V+A D                
Sbjct: 98   DGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGL 157

Query: 334  SATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVL 393
            SA  ++ V ++D ND+ PVF  S Y   + +  + G E++ + A+D+DS I   + Y ++
Sbjct: 158  SAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI 217

Query: 394  -GGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDE 452
             G    +F ++ ++G+ S    +    A  +    E  +      PL       +E ++E
Sbjct: 218  PGNVSSLFTIDSTTGLYSPEVEI--LSAVNFSADKEVMNSLEMFLPLLRHFKK-VERDEE 274

Query: 453  NDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSL 512
                   + + + ++      L+   L+VQ         AA  Y      + G+      
Sbjct: 275  AAEKKFEASRGWFMRFKGRRHLH--YLKVQDEAASADGEAAARYVANLAKILGE------ 326

Query: 513  SGILDVINPLDFEDVQKYSLSIKAQDGGR-PPLINSSGVVSVQVLDVNDNEPIFVSSPFQ 571
             GI+ +  PL   +    SL + AQDGG    +IN+   V++ +         F    + 
Sbjct: 327  -GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINAD--VTIHIFQTTLAPAEFERPKYT 383

Query: 572  ATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQ 631
              V E+VP   P+  ++A +  +     + YR+   +S  LGG               F 
Sbjct: 384  FLVYEDVPEDSPIGTVKAREPLNSSEP-IFYRI---SSGDLGG--------------KFS 425

Query: 632  IHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPT 691
            IH   G I     LD E        V+A   GS P  SST V+ITV+DVNDN P F + +
Sbjct: 426  IHPRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTS 484

Query: 692  YELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALP 749
             E+R+++    G+++   +A DRD+  N +I Y +        FA+   R  G++ L   
Sbjct: 485  DEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAID--RALGVLFLNGS 541

Query: 750  LDYKQEQQYVLAVTASD-GTRSHTAHVLINVT-DANTHRPVFQSSH--YTVSVSEDRPVG 805
            L   ++++  L + A D G     A +++ V  +   H P +   H  Y V VSE     
Sbjct: 542  LGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPM 601

Query: 806  TSIATLSANDEDTGENAR-ITYVIQDPVPQ--FRIDPDSGTMYTMMELDYENQVAYTLTI 862
            T +    A+       A  + Y ++  V    F I P +G +Y   + DYE+   Y   +
Sbjct: 602  TQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRV 661

Query: 863  MA--QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRD 920
             A   ++G  Q   TT + + + D NDN+P FL D     + E   P   I +++A D D
Sbjct: 662  FAWIPEDGFLQNVSTTVI-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 720

Query: 921  SGPNGRLLY-------------------------------TFQGGDDGDGD--------- 940
            SG NG+LLY                                F G D              
Sbjct: 721  SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLK 780

Query: 941  -FYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF 999
              + E   G +     LDRE+   + +  L  DRGSP P +A++ + V++ DINDN P F
Sbjct: 781  SLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSP-PRNATMAVYVSVTDINDNRPFF 839

Query: 1000 EK----DELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGD 1055
             +     EL + V E  PV  +V  + A DPDEG NA++ Y +   D    F++D  NG+
Sbjct: 840  PQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGE 899

Query: 1056 LRAMVELDFEVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNN-- 1110
            +R    L ++ R  Y + V AT     PL  +A V+I ++      P+     I+  N  
Sbjct: 900  IRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVI------PLSKGRAIMSQNIR 953

Query: 1111 YVTNKSNSFPTGVIGCIPAHD---PDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLD 1167
            ++    N  PT ++  I + D      +  L+++ V  ++     +D +TG+L LS++LD
Sbjct: 954  HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013

Query: 1168 NNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALF 1227
                   L  V  +D   +++   T+ ++I  +D          +N     F   L+ + 
Sbjct: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVED----------QNDHSPSFQDELIVIS 1063

Query: 1228 VEGVAAVLSTTKDDVFVFNVQND 1250
            VE    + +     V+VFN ++D
Sbjct: 1064 VEENVPIGTL----VYVFNAKDD 1082



 Score =  205 bits (521), Expect = 6e-52
 Identities = 225/902 (24%), Positives = 370/902 (41%), Gaps = 119/902 (13%)

Query: 375  IRASDRDSPINANLRYRVLGG-----AWDVFQLNESSGVVSTRAVLDRE-EAAEYQLLVE 428
            + ASD DS +   + Y +  G     A   F+++   G +     +DRE + A Y LLVE
Sbjct: 79   VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138

Query: 429  ANDQGRN--------PGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480
            A D             G LSA A V +++ED NDN+P F+   YV  + ++    T ++ 
Sbjct: 139  AKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIIN 198

Query: 481  VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGI----LDVINPLDFEDVQKYSLSIKA 536
            V ATD+D G    + Y ++ GNV+  F + S +G+    +++++ ++F   ++   S++ 
Sbjct: 199  VLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEM 258

Query: 537  QDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSP-FQATVLENVPLGYPVVHIQAVDADSG 595
                  PL+     V     D    E  F +S  +         L Y  V  +A  AD G
Sbjct: 259  F----LPLLRHFKKVE---RDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASAD-G 310

Query: 596  ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSF 655
            E A    R V   +  LG                       G I +   L   E    S 
Sbjct: 311  EAAA---RYVANLAKILG----------------------EGIIYLTLPLSHLESTTLSL 345

Query: 656  GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARD-R 714
             V A D G      +  V+I +         F +P Y   + ED    S + T++AR+  
Sbjct: 346  MVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPL 405

Query: 715  DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAH 774
            +++  I Y+++ G+   +F++  +   G I    PLD++ +   VL V A  G+    + 
Sbjct: 406  NSSEPIFYRISSGDLGGKFSIHPRL--GTIRTRKPLDHETQPVVVLTVQAQLGSAPACSS 463

Query: 775  VLINVT--DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPV 832
              +N+T  D N + P F  +   + +S+  P GT++    A D D+G N  I Y I  P 
Sbjct: 464  TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ 523

Query: 833  P-QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891
            P  F ID   G ++    L    Q   TLT+ A+D G+  ++    L + +++  +++P 
Sbjct: 524  PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPS 582

Query: 892  FLWD--FYQGSIFEDAPPSTSILQVSATDRDSGPN---GRLLYTFQGGDDGDGDFYIEPT 946
            + ++   YQ  + E   P T +LQ  A     GP      L Y+ +   D    F I P 
Sbjct: 583  WTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSVD-SAMFGIRPY 639

Query: 947  SGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL 1006
            +G I  +R+ D E+   YN    A         + S  + V + D NDN+P F  D L L
Sbjct: 640  TGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFL 699

Query: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQL----------------- 1049
             VEE+     V+ KI A D D G N Q++Y ++      FF++                 
Sbjct: 700  KVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGPAGTIYVITWAD 757

Query: 1050 ---------------------------DLLNGDLRAMVELDFEVRREY---VLVVQATSA 1079
                                       +L  G+L   V LD E R  +   VLV    S 
Sbjct: 758  GAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSP 817

Query: 1080 PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLN 1139
            P  +   V++ + D NDN P  P        +V          ++  + A DPD  ++  
Sbjct: 818  PRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAE 877

Query: 1140 YTFVQGNE--LRLLLLDPATGELQLSRDLD-NNRPLEALMEVSVSDGIHSVTAFCTLRVT 1196
             T+   +E       +D   GE++ +  L  + RP   +  ++   G+  +     + + 
Sbjct: 878  VTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQ 937

Query: 1197 II 1198
            +I
Sbjct: 938  VI 939



 Score =  202 bits (515), Expect = 3e-51
 Identities = 176/571 (30%), Positives = 272/571 (47%), Gaps = 47/571 (8%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F    YQV + E+ P G  +L L A  T     E +SY +     E     F ID   G 
Sbjct: 1992 FSQDFYQVTVPESIPVGYSVLTLSA--TDLESNENISYRILSSSKE-----FSIDPKNGT 2044

Query: 305  VSTDS-VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
            + T S VL  +T  T    V+A D   P   A T + + ++D N+++P F    Y   + 
Sbjct: 2045 IFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLS 2104

Query: 364  ENLEVGYEVLTIRASDRD-SPINANLRYRVLGG-AWDVFQLN----------ESSGVVST 411
            E+  VG  ++T    D D +  N  + Y ++ G + + F +           +  G +  
Sbjct: 2105 EDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVL 2164

Query: 412  RAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPED 471
               LDRE +A ++L++ A+D G  P  LS+TA + I+V D NDN P FS  +Y   V E 
Sbjct: 2165 LHSLDREASASHELVILASDSGCPP--LSSTAVISIQVLDVNDNPPNFSSLSYHTHVKES 2222

Query: 472  VGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYS 531
              L + +  V A DRD G +A I Y+I+SGN  G FYL   +G+L +I PLD+E + K++
Sbjct: 2223 TPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFT 2282

Query: 532  LSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVD 591
            L+++A D  +     S  VV V VLD ND+ P F+ S F   V EN+P+   +  I A+D
Sbjct: 2283 LTVQASDAEKKHF--SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALD 2340

Query: 592  ADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVE 651
             D+G    L Y +V  +  FL  G +   +        F I   +G I     LD E   
Sbjct: 2341 FDAGPYGELTYSIV--SPCFLTHGMSYDHD-------LFLIDPLTGDIHAKQILDYENGN 2391

Query: 652  HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA 711
             Y   V+A D G    ++S  V + +  +++ +P+FTQ  Y   L E       +  ++A
Sbjct: 2392 KYCLTVQAKDKGD--ATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEA 2449

Query: 712  RDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQ------EQQYVLAVT 763
             D DA  + VI Y L  G +   F+++   G   +  ALPL   Q       +  ++A +
Sbjct: 2450 SDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHS 2507

Query: 764  ASDGTRSHTAHVLINVTDANTHRP--VFQSS 792
                ++  +  V +NV+ ++   P  VF SS
Sbjct: 2508 PKSDSKFASCTVFVNVSFSSEGTPLAVFASS 2538



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 44/163 (26%), Positives = 73/163 (44%), Gaps = 13/163 (7%)

Query: 913  QVSATDRDSGPNGRLLYTFQGGD---DGDGDFYIEPTSGVIRTQRRLDRE-NVAVYNLWA 968
            +V+A+D DSG  G + Y+   G    +    F I+P  G I   + +DRE + A Y+L  
Sbjct: 78   EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137

Query: 969  LAVDRGSPTP---------LSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVA 1019
             A D               LSA   ++V + D+NDN P+F        + +    G+ + 
Sbjct: 138  EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197

Query: 1020 KIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVEL 1062
             + A D D G    + Y+++ G++   F +D   G     VE+
Sbjct: 198  NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI 240



 Score = 37.4 bits (85), Expect = 0.23
 Identities = 42/171 (24%), Positives = 71/171 (41%), Gaps = 26/171 (15%)

Query: 1009 EENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRH----FFQLDLLNGDLRAMVELDF 1064
            +E N       ++ A+D D G    I Y + +G + +     F++D  +G +    ++D 
Sbjct: 67   QEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDR 126

Query: 1065 EVR-REYVLVVQATSAP-------------LVSRATVHILLVDQNDNPPVLPDFQILFNN 1110
            E     Y L+V+A                 L ++A V + L D NDN PV        + 
Sbjct: 127  ERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNP-----ST 181

Query: 1111 YVTNKSNSFPTG--VIGCIPA-HDPDVSDSLNYTFVQGNELRLLLLDPATG 1158
            YVT+ S+    G  +I  +    D  +  ++ Y  + GN   L  +D  TG
Sbjct: 182  YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 232


>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
          Length = 1369

 Score =  326 bits (835), Expect = 2e-88
 Identities = 247/766 (32%), Positives = 376/766 (49%), Gaps = 57/766 (7%)

Query: 296  FRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQ 355
            F IDS +GA+ST   LDRE +E   L+V A D   PP SAT  +++ V D ND+ P+F +
Sbjct: 606  FAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWR 665

Query: 356  SEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-----AWDVFQLNESSGVVS 410
              Y   + E+  VG+  L + ASD DS +   + Y +  G     A   F+++   G + 
Sbjct: 666  QVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQIC 725

Query: 411  TRAVLDRE-EAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVP 469
                +DRE + A Y LLVEA D G     LSA A V +++ED NDN+P F+   YV  + 
Sbjct: 726  VSQDIDRERDPATYDLLVEAKDGGG----LSAQAFVRVDLEDVNDNHPVFNPSTYVTSIS 781

Query: 470  EDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQK 529
            ++    T ++ V ATD+D G    + Y ++ GNV+  F + S +GI+ +  PL   +   
Sbjct: 782  DETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTT 841

Query: 530  YSLSIKAQD-GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQ 588
             SL + AQD GG   +IN+   V++ +         F    +   V E+VP   P+  ++
Sbjct: 842  LSLMVSAQDGGGLTAVINAD--VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 899

Query: 589  AVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE 648
            A +     +  + YR+   +S  LGG               F IH   G I     LD E
Sbjct: 900  ARE-PLNSSEPIFYRI---SSGDLGG--------------KFSIHPRLGTIRTRKPLDHE 941

Query: 649  EVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708
                    V+A   GS P  SST V+ITV+DVNDN P F + + E+R+++    G+++  
Sbjct: 942  TQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYL 1000

Query: 709  LQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
             +A DRD+  N +I Y +        FA+   R  G++ L   L   ++++  L + A D
Sbjct: 1001 ARAEDRDSGRNGLIRYSIASPQP-GVFAI--DRALGVLFLNGSLGAGEQRELTLTLRAED 1057

Query: 767  -GTRSHTAHVLINVT-DANTHRPVFQSSH--YTVSVSEDRPVGTSIATLSANDEDTGENA 822
             G     A +++ V  +   H P +   H  Y V VSE     T +    A+       A
Sbjct: 1058 QGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAA 1117

Query: 823  R-ITYVIQDPV--PQFRIDPDSGTMYTMMELDYENQVAYTLTIMA--QDNGIPQKSDTTT 877
              + Y ++  V    F I P +G +Y   + DYE+   Y   + A   ++G  Q   TT 
Sbjct: 1118 SPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTV 1177

Query: 878  LEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDG 937
            + + + D NDN+P FL D     + E   P   I +++A D DSG NG+LLY        
Sbjct: 1178 I-VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL----S 1232

Query: 938  DGDFY-IEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNA 996
            DG F+ + P +G +     LDRE+   + +  L  DRGSP P +A++ + V++ DINDN 
Sbjct: 1233 DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSP-PRNATMAVYVSVTDINDNR 1291

Query: 997  PMFEK----DELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQI 1038
            P F +     EL + V E  PV  +V  + A DPDEG NA++ Y +
Sbjct: 1292 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337



 Score =  309 bits (791), Expect = 3e-83
 Identities = 280/914 (30%), Positives = 404/914 (44%), Gaps = 75/914 (8%)

Query: 311  LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370
            LDRE    H L+++A D   P R+    + + V D ND+ PVFEQ EYR  VRE+ + G 
Sbjct: 254  LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGA 313

Query: 371  EVLTIRASDRDSPINANLRYRVL----------GGAWD---VFQLNESSGVVSTRAVLDR 417
            EV  +RA+DRD   N  +RY V           GGA      F + E SGVV     LDR
Sbjct: 314  EVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDR 373

Query: 418  EEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQ----FSEQNYVVQVPEDVG 473
            E  A +QL+VEA D G  P    AT  V I V D NDN P     F  +  V +V E   
Sbjct: 374  EAQAWHQLVVEARDGGAEPE--VATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGAR 431

Query: 474  LNTAVLRVQATDRDQG------------------------QNAAIHYSILSGNVAGQFYL 509
                V RV  +D D                          +     +++L G   G F+ 
Sbjct: 432  PGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFF- 490

Query: 510  HSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSP 569
                  L V  PLD E    Y L + A D G PPL ++   + ++V D+ND  P+F    
Sbjct: 491  ------LCVEGPLDRESRDLYELLLVATDAGSPPL-STEETLLLRVADLNDQPPLFSQQH 543

Query: 570  FQATVLENVPLGYPVVHIQAVDAD--SGENARLHYRLVDTASTFLGGGSAGPKNPAPTPD 627
            ++A+V E    G  V+ + A DAD    ++A L Y +V  ++    G             
Sbjct: 544  YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG 603

Query: 628  FPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVF 687
              F I + SG I+    LDRE  E     V A D G PP+S++  VSITV DVNDN+P+F
Sbjct: 604  PSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIF 663

Query: 688  TQPTYELRLNEDAAVGSSVLTLQARDRDAN--SVITYQLTGG--NTRNRFALSSQRGGGL 743
             +  Y   + E A VG   L + A D D+     I Y L  G  +     A       G 
Sbjct: 664  WRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQ 723

Query: 744  ITLALPLDYKQE-QQYVLAVTASD-GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSED 801
            I ++  +D +++   Y L V A D G  S  A V +++ D N + PVF  S Y  S+S++
Sbjct: 724  ICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDE 783

Query: 802  RPVGTSIATLSANDEDTGENARITY-VIQDPVPQ-FRIDPDSGTMYTMMELDYENQVAYT 859
               GT I  + A D+D+G    + Y +I   V   F ID  +G +Y  + L +      +
Sbjct: 784  TQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLS 843

Query: 860  LTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATD- 918
            L + AQD G         + I I        +F    Y   ++ED P  + I  V A + 
Sbjct: 844  LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP 903

Query: 919  -RDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPT 977
               S P   + Y    GD G G F I P  G IRT++ LD E   V  L  +    GS  
Sbjct: 904  LNSSEP---IFYRISSGDLG-GKFSIHPRLGTIRTRKPLDHETQPVVVL-TVQAQLGS-A 957

Query: 978  PLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQ 1037
            P  +S E+ +T++D+NDN P F +   E+ + +  P G+ +   RA D D G N  I Y 
Sbjct: 958  PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 1017

Query: 1038 IVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHIL--LVDQN 1095
            I        F +D   G L     L    +RE  L ++A    +  +A + +L  ++++ 
Sbjct: 1018 IA-SPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKR 1076

Query: 1096 DNPPVLPDFQILFNNYVTNKSNSFPTGVI--GCIPAHDPDVSDSLNYTFVQGNELRLLLL 1153
            ++ P    F+ L      ++S S  T ++     P      +  L Y+     +  +  +
Sbjct: 1077 EHSPSW-TFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGI 1135

Query: 1154 DPATGELQLSRDLD 1167
             P TG + L R  D
Sbjct: 1136 RPYTGWIYLRRQFD 1149



 Score =  292 bits (748), Expect = 3e-78
 Identities = 293/1028 (28%), Positives = 437/1028 (42%), Gaps = 101/1028 (9%)

Query: 249  NYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYM-EGLFDERSRGYFRIDSATGAVST 307
            N  +++ E  P  TL+  + A      ++E   +++ E   D      F +   TG + T
Sbjct: 68   NLTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRT 127

Query: 308  DSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLE 367
               LDRE ++ +      +        A   + + V D NDHSP F     +  V E   
Sbjct: 128  ARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSP 181

Query: 368  VGYEVLTIRASDRDSPINA---------------------NLRYRVLGGAWDVFQLNESS 406
             G       A D D+ + +                      LRYR  G          SS
Sbjct: 182  PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241

Query: 407  GVVSTRAV----LDREEAAEYQLLVEANDQG--RNPGPLSATATVYIEVEDENDNYPQFS 460
             +     V    LDREEAA ++L +EA D G  R  G LS    V + V DENDN P F 
Sbjct: 242  PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLS----VELRVLDENDNPPVFE 297

Query: 461  EQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAG------------QFY 508
            +  Y   V ED      V RV+ATDRD G N  + YS+ +  V G             F 
Sbjct: 298  QDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFA 357

Query: 509  LHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEP----I 564
            +  LSG++ V  PLD E    + L ++A+DGG  P + ++  VS+ VLDVNDN P    +
Sbjct: 358  VEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEV-ATVRVSIAVLDVNDNRPAIHVL 416

Query: 565  FVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAP 624
            F++    A V E    G  V  +   DAD   +              LG GS        
Sbjct: 417  FLTEGGVARVSEGARPGDYVARVSVSDADG--DWEKEDEATGELGVGLGDGSISLSLEGG 474

Query: 625  TPDFPFQIHNSSGWITVCAE--LDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVND 682
              DF        G   +C E  LDRE  + Y   + A D GSPP+S+  ++ + V D+ND
Sbjct: 475  EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLND 534

Query: 683  NDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA----NSVITY---QLTG----GNTRN 731
              P+F+Q  Y+  ++E AA G+ V+ + A D D     ++ + Y   QL+     G+ ++
Sbjct: 535  QPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQS 594

Query: 732  RFALSSQRG--------GGLITLALPLDYKQEQQYVLAVTASD---GTRSHTAHVLINVT 780
            +   +++ G         G I+    LD + ++   L V A D      S T  V I V 
Sbjct: 595  KMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVD 654

Query: 781  DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD-----PVPQ- 834
            D N + P+F    Y  +++E  PVG     ++A+D D+G    I Y + D       PQ 
Sbjct: 655  DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQA 714

Query: 835  FRIDPDSGTMYTMMELDYENQVA-YTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
            FRIDP  G +    ++D E   A Y L + A+D G    S    + + + D NDN P F 
Sbjct: 715  FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDLEDVNDNHPVFN 772

Query: 894  WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ 953
               Y  SI ++  P T I+ V ATD+DSG  G + Y    G +    F I+ T+G+I   
Sbjct: 773  PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG-NVSSLFTIDSTTGIIYLT 831

Query: 954  RRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNP 1013
              L        +L   A D G  T +  + ++ + I         FE+ +    V E+ P
Sbjct: 832  LPLSHLESTTLSLMVSAQDGGGLTAV-INADVTIHIFQTTLAPAEFERPKYTFLVYEDVP 890

Query: 1014 VGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLV 1073
              S +  ++A +P    +  I Y+I  GD+   F +    G +R    LD E +   VL 
Sbjct: 891  EDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLT 949

Query: 1074 VQAT--SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHD 1131
            VQA   SAP  S   V+I ++D NDN P      +  ++ +     + P   +    A D
Sbjct: 950  VQAQLGSAPACSSTEVNITVMDVNDNHPAF----LRTSDEIRISQTTPPGTALYLARAED 1005

Query: 1132 PDVS-DSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTA 1189
             D   + L    +   +  +  +D A G L L+  L      E  + +   D G+H   A
Sbjct: 1006 RDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAA 1065

Query: 1190 FCTLRVTI 1197
               L V I
Sbjct: 1066 LLVLTVVI 1073



 Score =  291 bits (745), Expect = 7e-78
 Identities = 250/869 (28%), Positives = 388/869 (44%), Gaps = 67/869 (7%)

Query: 311  LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370
            LDRE+++ + L + A D  +PP S    + + V D ND  P+F Q  Y+  V E    G 
Sbjct: 497  LDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGT 556

Query: 371  EVLTIRASDRDSP--INANLRYRVL------------------GGAWDVFQLNESSGVVS 410
             V+ + ASD D     +A LRY V+                        F ++  SG +S
Sbjct: 557  VVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIS 616

Query: 411  TRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPE 470
            T   LDRE     +L V A D G  P  LSAT  V I V+D NDN P F  Q Y   + E
Sbjct: 617  TIRTLDREVQEAVELKVVAQDLGEPP--LSATCLVSITVDDVNDNEPIFWRQVYNATIAE 674

Query: 471  DVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQ----FYLHSLSGILDVINPLDFE- 525
               +    L+V A+D D G    I YS+  G ++ +    F +    G + V   +D E 
Sbjct: 675  HAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRER 734

Query: 526  DVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVV 585
            D   Y L ++A+DGG    +++   V V + DVNDN P+F  S +  ++ +    G  ++
Sbjct: 735  DPATYDLLVEAKDGGG---LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 791

Query: 586  HIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAEL 645
            ++ A D DSG    + Y L+             P N +      F I +++G I +   L
Sbjct: 792  NVLATDQDSGIYGTVAYELI-------------PGNVSSL----FTIDSTTGIIYLTLPL 834

Query: 646  DREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSS 705
               E    S  V A D G      +  V+I +         F +P Y   + ED    S 
Sbjct: 835  SHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSP 894

Query: 706  VLTLQARDR-DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTA 764
            + T++AR+  +++  I Y+++ G+   +F++  + G   I    PLD++ +   VL V A
Sbjct: 895  IGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG--TIRTRKPLDHETQPVVVLTVQA 952

Query: 765  SDGTRSHTAHVLINVT--DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENA 822
              G+    +   +N+T  D N + P F  +   + +S+  P GT++    A D D+G N 
Sbjct: 953  QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 1012

Query: 823  RITYVIQDPVPQ-FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEIL 881
             I Y I  P P  F ID   G ++    L    Q   TLT+ A+D G+  ++    L ++
Sbjct: 1013 LIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVV 1072

Query: 882  ILDANDNAPQFLWDF--YQGSIFEDAPPSTSILQVSATDRDSGPN---GRLLYTFQGGDD 936
            I +  +++P + ++   YQ  + E   P T +LQ  A     GP      L Y+ +   D
Sbjct: 1073 I-EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSVD 1129

Query: 937  GDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNA 996
                F I P +G I  +R+ D E+   YN    A         + S  + V + D NDN+
Sbjct: 1130 S-AMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNS 1188

Query: 997  PMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDL 1056
            P F  D L L VEE+     V+ KI A D D G N Q++Y ++      FF+++   G+L
Sbjct: 1189 PTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNTGEL 1246

Query: 1057 RAMVELDFEVRREY---VLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVT 1113
               V LD E R  +   VLV    S P  +   V++ + D NDN P  P        +V 
Sbjct: 1247 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 1306

Query: 1114 NKSNSFPTGVIGCIPAHDPDVSDSLNYTF 1142
                     ++  + A DPD  ++   T+
Sbjct: 1307 VLEGQPVNMLVTTVFAKDPDEGNNAEVTY 1335



 Score =  290 bits (741), Expect = 2e-77
 Identities = 316/1123 (28%), Positives = 467/1123 (41%), Gaps = 129/1123 (11%)

Query: 138  GCAAAQHSALAAPTTLPA----------CRCP-PRPRPRCPGRPICLPPGGSVRLRLLCA 186
            G  + Q   L  P+ LP            R P P P P  PG    L P   V LR L  
Sbjct: 197  GLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLD- 255

Query: 187  LRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFP 246
             R  A A R  L +EA   G P  +   S  L   L E    P               F 
Sbjct: 256  -REEAAAHR--LQIEAWDGGRPRRTGLLSVELRV-LDENDNPPV--------------FE 297

Query: 247  MPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYME-----------GLFDERSRGY 295
               Y+ A+ E+   G  + ++ A     G    V Y +            G   + +  Y
Sbjct: 298  QDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAA--Y 355

Query: 296  FRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQ 355
            F ++  +G V     LDRE +  H L V+A D    P  AT  +++ V D ND+ P    
Sbjct: 356  FAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHV 415

Query: 356  SEYRE----RVRENLEVGYEVLTIRASDRDSPI---------------NANLRYRVLGGA 396
                E    RV E    G  V  +  SD D                  + ++   + GG 
Sbjct: 416  LFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGE 475

Query: 397  WDVFQL-NESSGV--VSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDEN 453
             D   L     GV  +     LDRE    Y+LL+ A D G    PLS   T+ + V D N
Sbjct: 476  GDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAG--SPPLSTEETLLLRVADLN 533

Query: 454  DNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ--GQNAAIHYSIL------------ 499
            D  P FS+Q+Y   V E     T V+ V A+D D+    +A + Y+++            
Sbjct: 534  DQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQ 593

Query: 500  -----SGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQ 554
                 +      F + S SG +  I  LD E  +   L + AQD G PPL +++ +VS+ 
Sbjct: 594  SKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPL-SATCLVSIT 652

Query: 555  VLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGG 614
            V DVNDNEPIF    + AT+ E+ P+G+  + + A DADSG    + Y L D   ++   
Sbjct: 653  VDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSY--- 709

Query: 615  GSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE-EVEHYSFGVEAVDHGSPPMSSSTSV 673
                    AP     F+I    G I V  ++DRE +   Y   VEA D G   +S+   V
Sbjct: 710  -------EAPQ---AFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG--LSAQAFV 757

Query: 674  SITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDAN--SVITYQLTGGNTRN 731
             + + DVNDN PVF   TY   ++++   G+ ++ + A D+D+     + Y+L  GN  +
Sbjct: 758  RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS 817

Query: 732  RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPV 788
             F + S    G+I L LPL + +     L V+A DG   T    A V I++         
Sbjct: 818  LFTIDSTT--GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875

Query: 789  FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQFRIDPDSGTMYT 846
            F+   YT  V ED P  + I T+ A  E    +  I Y I   D   +F I P  GT+ T
Sbjct: 876  FERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRT 934

Query: 847  MMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAP 906
               LD+E Q    LT+ AQ    P  S +T + I ++D NDN P FL    +  I +  P
Sbjct: 935  RKPLDHETQPVVVLTVQAQLGSAPACS-STEVNITVMDVNDNHPAFLRTSDEIRISQTTP 993

Query: 907  PSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNL 966
            P T++    A DRDSG NG + Y+        G F I+   GV+     L         L
Sbjct: 994  PGTALYLARAEDRDSGRNGLIRYSI--ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTL 1051

Query: 967  WALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDP 1026
               A D+G      A++ +   +++  +++P +  + L   VE +  +  +   ++    
Sbjct: 1052 TLRAEDQG--VHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAH 1109

Query: 1027 DEGPN---AQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA---TSAP 1080
              GP    + + Y +        F +    G +    + D+E  + Y   V A       
Sbjct: 1110 PLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF 1169

Query: 1081 LVSRATVHILLV-DQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLN 1139
            L + +T  I+ V D+NDN P      +LF   +  + +  P GVIG I A D D   +  
Sbjct: 1170 LQNVSTTVIVRVWDENDNSPTFL-HDVLF---LKVEESPVPQGVIGKITAIDMDSGKNGQ 1225

Query: 1140 YTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
              +   ++ +   ++P TGEL     LD        M V V+D
Sbjct: 1226 LLYFLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTD 1268



 Score =  255 bits (652), Expect = 4e-67
 Identities = 253/891 (28%), Positives = 374/891 (41%), Gaps = 112/891 (12%)

Query: 398  DVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYP 457
            D F ++  +G++ T   LDRE    Y  +            L A   V I V D ND+ P
Sbjct: 114  DDFHVHPDTGIIRTARRLDRERRDHYSFVAATL--------LGAVVQVEIRVNDVNDHSP 165

Query: 458  QFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI-----LSGNVAGQFY---- 508
            +F   +  + V E     TA     A D D G  +   Y++     L  + AG F+    
Sbjct: 166  RFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRY 225

Query: 509  -----LHS--LSGILDVINPLDF--------EDVQKYSLSIKAQDGGRPPLINSSGVVSV 553
                 L S  L G    + PLD         E+   + L I+A DGGRP     +G++SV
Sbjct: 226  RTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP---RRTGLLSV 282

Query: 554  Q--VLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTF 611
            +  VLD NDN P+F    ++A V E+   G  V  ++A D D G N  + Y +   A   
Sbjct: 283  ELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSV--RARQV 340

Query: 612  LGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSST 671
             G GS G    A      F +   SG + V   LDRE    +   VEA D G+ P  ++ 
Sbjct: 341  PGAGSGGG---ALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATV 397

Query: 672  SVSITVLDVNDNDP----VFTQPTYELRLNEDAAVGSSVLTLQARDRDAN---------- 717
             VSI VLDVNDN P    +F       R++E A  G  V  +   D D +          
Sbjct: 398  RVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGE 457

Query: 718  -------SVITYQLTGGNTRNRFALSSQRGGGLITLAL--PLDYKQEQQYVLAVTASDGT 768
                     I+  L GG     FAL      G+  L +  PLD +    Y L + A+D  
Sbjct: 458  LGVGLGDGSISLSLEGGE--GDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAG 515

Query: 769  R---SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENAR 823
                S    +L+ V D N   P+F   HY  SVSE    GT +  +SA+D D    ++A 
Sbjct: 516  SPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAW 575

Query: 824  ITYVI-------------------QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMA 864
            + Y +                    +  P F ID +SG + T+  LD E Q A  L ++A
Sbjct: 576  LRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVA 635

Query: 865  QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924
            QD G P  S T  + I + D NDN P F    Y  +I E AP     LQV+A+D DSG  
Sbjct: 636  QDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLY 695

Query: 925  GRLLYTFQGG---DDGDGDFYIEPTSGVIRTQRRLDRE-NVAVYNLWALAVDRGSPTPLS 980
            G + Y+   G    +    F I+P  G I   + +DRE + A Y+L   A D G    LS
Sbjct: 696  GFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG---LS 752

Query: 981  ASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE 1040
            A   ++V + D+NDN P+F        + +    G+ +  + A D D G    + Y+++ 
Sbjct: 753  AQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIP 812

Query: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQA-----TSAPLVSRATVHILLVDQN 1095
            G++   F +D   G +   + L         L+V A      +A + +  T+HI      
Sbjct: 813  GNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLA 872

Query: 1096 DNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDP-DVSDSLNYTFVQGNELRLLLLD 1154
                  P +  L    V   S       IG + A +P + S+ + Y    G+      + 
Sbjct: 873  PAEFERPKYTFLVYEDVPEDS------PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIH 926

Query: 1155 PATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTN 1205
            P  G ++  + LD+    + ++ ++V   + S  A  +  V I   D+  N
Sbjct: 927  PRLGTIRTRKPLDHE--TQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDN 975



 Score =  142 bits (357), Expect = 7e-33
 Identities = 151/604 (25%), Positives = 251/604 (41%), Gaps = 47/604 (7%)

Query: 245  FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
            F    Y  ++ +    GT I+ + A     G    V+Y    L        F IDS TG 
Sbjct: 771  FNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYE---LIPGNVSSLFTIDSTTGI 827

Query: 305  VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
            +     L      T  L V A D           +T+ +  T      FE+ +Y   V E
Sbjct: 828  IYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYE 887

Query: 365  NLEVGYEVLTIRASDRDSPINAN--LRYRVLGG-AWDVFQLNESSGVVSTRAVLDREEAA 421
            ++     + T++A +   P+N++  + YR+  G     F ++   G + TR  LD E   
Sbjct: 888  DVPEDSPIGTVKARE---PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP 944

Query: 422  EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRV 481
               L V+A        P  ++  V I V D NDN+P F   +  +++ +     TA+   
Sbjct: 945  VVVLTVQAQ---LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 1001

Query: 482  QATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGR 541
            +A DRD G+N  I YSI S    G F +    G+L +   L   + ++ +L+++A+D G 
Sbjct: 1002 RAEDRDSGRNGLIRYSIASPQ-PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 1060

Query: 542  PPLINSSGVVSVQVLDVNDNEP--IFVSSPFQATVLENVPLGYPVVHIQAVDADSGENAR 599
             P   ++ +V   V++  ++ P   F    +Q  V E++     ++  QA        A 
Sbjct: 1061 HP--QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS 1118

Query: 600  -LHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658
             L Y L  +  + +                 F I   +GWI +  + D E  + Y+F V 
Sbjct: 1119 PLRYSLEPSVDSAM-----------------FGIRPYTGWIYLRRQFDYESTQTYNFRVF 1161

Query: 659  A-VDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDAN 717
            A +       + ST+V + V D NDN P F      L++ E       +  + A D D+ 
Sbjct: 1162 AWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSG 1221

Query: 718  S---VITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVT-ASDGTRSHTA 773
                ++ + L+ G     F ++   G  +  +AL  +++   +  + VT      R+ T 
Sbjct: 1222 KNGQLLYFLLSDGKF---FKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278

Query: 774  HVLINVTDANTHRPVFQS----SHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ 829
             V ++VTD N +RP F          V V E +PV   + T+ A D D G NA +TY + 
Sbjct: 1279 AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338

Query: 830  DPVP 833
               P
Sbjct: 1339 SARP 1342



 Score = 99.0 bits (245), Expect = 6e-20
 Identities = 101/380 (26%), Positives = 159/380 (41%), Gaps = 27/380 (7%)

Query: 251  QVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSV 310
            ++ + +  P GT +    A     G    + Y +         G F ID A G +  +  
Sbjct: 985  EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS----PQPGVFAIDRALGVLFLNGS 1040

Query: 311  LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSP--VFEQSEYRERVRENLEV 368
            L    +    L ++A D    P++A   +TV++ +  +HSP   FE   Y+  V E+L  
Sbjct: 1041 LGAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSP 1099

Query: 369  GYEVLTIRASDRD-----SPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
              ++L  +A         SP+  +L   V      +F +   +G +  R   D E    Y
Sbjct: 1100 MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSA---MFGIRPYTGWIYLRRQFDYESTQTY 1156

Query: 424  QLLVEANDQGRNPGPL-SATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ 482
               V A       G L + + TV + V DENDN P F      ++V E       + ++ 
Sbjct: 1157 NFRVFAWIP--EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKIT 1214

Query: 483  ATDRDQGQNAAIHYSILSGNVAGQFY-LHSLSGILDVINPLDFEDVQKYSLSIKAQDGGR 541
            A D D G+N  + Y +LS    G+F+ ++  +G L     LD E    + +++   D G 
Sbjct: 1215 AIDMDSGKNGQLLYFLLSD---GKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGS 1271

Query: 542  PPLINSSGVVSVQVLDVNDNEPIFVS----SPFQATVLENVPLGYPVVHIQAVDADSGEN 597
            PP  N++  V V V D+NDN P F            VLE  P+   V  + A D D G N
Sbjct: 1272 PPR-NATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 1330

Query: 598  ARLHYRLVDTASTFLGGGSA 617
            A + Y +       L G +A
Sbjct: 1331 AEVTYSVSSARPMPLKGKTA 1350


>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
          Length = 1237

 Score =  291 bits (744), Expect = 9e-78
 Identities = 210/690 (30%), Positives = 330/690 (47%), Gaps = 58/690 (8%)

Query: 447  IEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQ 506
            IEV+D NDN P F+     + +PE+  + +      A+DRD G N    Y + +G  A +
Sbjct: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215

Query: 507  FY-------LHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVN 559
             +              L V+  LD E    Y L+IK QDGG PP   SS ++ V VLD N
Sbjct: 216  LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRA-SSALLRVTVLDTN 274

Query: 560  DNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGP 619
            DN P F    ++A + EN P+G+ V+ ++A D+D G NA + Y       TF        
Sbjct: 275  DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEY-------TF-------- 319

Query: 620  KNPAP-TPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVL 678
             + AP       ++  ++G ITV   +DRE++    F V A D G+ P S+   V +TV 
Sbjct: 320  -HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVK 378

Query: 679  DVNDNDP--------VFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGN 728
            D+NDN P        + T       ++ED A  ++V  +Q  DRD   N+ +T  +  G+
Sbjct: 379  DMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTC-VVAGD 437

Query: 729  TRNRFALSSQRGGG-----LITLALPLDYKQEQQYVLAVTASDGTR---SHTAHVLINVT 780
               +   +S+ G        +    PLDY++ + Y + + A D      S T  + + V 
Sbjct: 438  VPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVV 497

Query: 781  DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ----FR 836
            D N + PVF  S   V+  E+   G  IA ++A+D D+G NA + Y + +P P     F 
Sbjct: 498  DVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL-EPEPAAKGLFT 556

Query: 837  IDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDF 896
            I P++G +     LD E + +Y L ++A D G P    T T+ + +LD NDN P+F+   
Sbjct: 557  ISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSG 616

Query: 897  YQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRL 956
            Y  S+ E+ P  + +  V+  D D G N ++  +    +  +GDF I+  +G I +    
Sbjct: 617  YNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV---EQDNGDFVIQNGTGTILSSLSF 673

Query: 957  DRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF--EKDELELFVEENNPV 1014
            DRE  + Y     AVD G P P SA V + + +LD NDNAP      +     +     +
Sbjct: 674  DREQQSTYTFQLKAVDGGVP-PRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL 732

Query: 1015 GSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVV 1074
            G  V+++ A D D G NA+++Y I  G+    FQ+   +G +    E++      + LVV
Sbjct: 733  GETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVV 792

Query: 1075 QAT---SAPLVSRATVHILLVDQNDNPPVL 1101
            + +     P    A VH+ + +   N  +L
Sbjct: 793  KVSDRGKPPRYGTALVHLYVNETLANRTLL 822



 Score =  279 bits (713), Expect = 3e-74
 Identities = 193/597 (32%), Positives = 291/597 (48%), Gaps = 47/597 (7%)

Query: 311 LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370
           LDRE  +++ L +K  D  +PPR+++  + V V DTND++P FE+  Y   + EN  +G+
Sbjct: 238 LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 297

Query: 371 EVLTIRASDRDSPINANLRYRVLGGAWDV---FQLNESSGVVSTRAVLDREEAAEYQLLV 427
            V+ ++A+D D   NA + Y        V    +L+ ++G+++ +  +DRE+ +  +  V
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSV 357

Query: 428 EANDQGRNPGPLSATATVYIEVEDENDNYPQF--------SEQNYVVQVPEDVGLNTAVL 479
            A D+G N  P SA A V + V+D NDN P          + Q+ +  + EDV   TAV 
Sbjct: 358 LAKDRGTN--PKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVA 415

Query: 480 RVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSG-------ILDVINPLDFEDVQKYSL 532
            VQ +DRD+G+NAA+   +++G+V  Q    S +G        L    PLD+E V+ Y++
Sbjct: 416 LVQVSDRDEGENAAV-TCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTI 474

Query: 533 SIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDA 592
            I A D G PPL +S+  + VQV+DVNDN P+F  S  +    EN   G  +  I A DA
Sbjct: 475 EIVAVDSGNPPL-SSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDA 533

Query: 593 DSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEH 652
           DSG NA L Y L                 P P     F I   +G I V   LDRE+ E 
Sbjct: 534 DSGSNAELVYSL----------------EPEPAAKGLFTISPETGEIQVKTSLDREQRES 577

Query: 653 YSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQAR 712
           Y   V A D GSP +  + +V + VLD NDNDP F    Y   + E+    S V  +   
Sbjct: 578 YELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVI 637

Query: 713 DRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TR 769
           D D       QL+       F +  Q G G I  +L  D +Q+  Y   + A DG    R
Sbjct: 638 DGDKGENAQVQLSVEQDNGDFVI--QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPR 695

Query: 770 SHTAHVLINVTDANTHRPVFQSSHYTVS--VSEDRPVGTSIATLSANDEDTGENARITYV 827
           S    V INV D N + P   +   T    ++    +G +++ ++A D D+G NA + Y 
Sbjct: 696 SAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS 755

Query: 828 IQ--DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILI 882
           I   +P   F+I   SG +    E++  +   + L +   D G P +  T  + + +
Sbjct: 756 IAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812



 Score =  270 bits (689), Expect = 2e-71
 Identities = 233/779 (29%), Positives = 347/779 (44%), Gaps = 102/779 (13%)

Query: 256 ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAV-STDSVLDRE 314
           E +P  TLI  L A Y                  E    Y R+D  TG + +T++ +DRE
Sbjct: 66  EEQPPNTLIGSLAADYGFPDVGHLYKL-------EVGAPYLRVDGKTGDIFTTETSIDRE 118

Query: 315 -TKETH----------VLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
             +E               V   D             + V+D ND++P F        + 
Sbjct: 119 GLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIP 178

Query: 364 ENLEVGYEVLTIRASDRDSPINANLRYRVLGG--AWDVFQL------NESSGVVSTRAVL 415
           EN  +G       ASDRD+  N    Y +  G  A ++F L       E    +     L
Sbjct: 179 ENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNL 238

Query: 416 DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLN 475
           DRE    Y L ++  D G    P +++A + + V D NDN P+F   +Y  ++ E+  + 
Sbjct: 239 DRERWDSYDLTIKVQDGG--SPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIG 296

Query: 476 TAVLRVQATDRDQGQNAAIHYSILSGN--VAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
            +V++V+A D DQG NA I Y+       V     L   +G++ V  P+D ED+     S
Sbjct: 297 HSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFS 356

Query: 534 IKAQDGGRPPLINSSGVVSVQVLDVNDNEP--------IFVSSPFQATVLENVPLGYPVV 585
           + A+D G  P    + VV V V D+NDN P        +       A + E+V     V 
Sbjct: 357 VLAKDRGTNPKSARAQVV-VTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVA 415

Query: 586 HIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSG-------- 637
            +Q  D D GENA         A T +  G           D PFQ+  +S         
Sbjct: 416 LVQVSDRDEGENA---------AVTCVVAG-----------DVPFQLRQASETGSDSKKK 455

Query: 638 -WITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRL 696
            ++     LD E+V+ Y+  + AVD G+PP+SS+ S+ + V+DVNDN PVFTQ   E+  
Sbjct: 456 YFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAF 515

Query: 697 NEDAAVGSSVLTLQARDRD--ANSVITYQL-TGGNTRNRFALSSQRGGGLITLALPLDYK 753
            E+   G  +  + A D D  +N+ + Y L      +  F +S + G   I +   LD +
Sbjct: 516 PENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE--IQVKTSLDRE 573

Query: 754 QEQQYVLAVTASD-GTRS--HTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIAT 810
           Q + Y L V A+D G+ S   TA VL+NV D N + P F  S Y  SV E+ P  + +  
Sbjct: 574 QRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGM 633

Query: 811 LSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP 870
           ++  D D GENA++   ++     F I   +GT+ + +  D E Q  YT  + A D G+P
Sbjct: 634 VTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVP 693

Query: 871 QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTS-------------ILQVSAT 917
            +S    + I +LD NDNAP           +  AP +TS             + QV+A 
Sbjct: 694 PRSAYVGVTINVLDENDNAP-----------YITAPSNTSHKLLTPQTRLGETVSQVAAE 742

Query: 918 DRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSP 976
           D DSG N  L+Y+  GG+   G F I   SG I  ++ ++R +  ++ L     DRG P
Sbjct: 743 DFDSGVNAELIYSIAGGNP-YGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP 800



 Score =  266 bits (681), Expect = 2e-70
 Identities = 206/673 (30%), Positives = 312/673 (46%), Gaps = 53/673 (7%)

Query: 540  GRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENAR 599
            G P L+       ++V D+NDN P F S      + EN  +G       A D D+G N  
Sbjct: 147  GSPRLLEGQ----IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGV 202

Query: 600  LHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQI----HNSSGWITVCAELDREEVEHYSF 655
              Y L            AGP+       F  Q+          + V   LDRE  + Y  
Sbjct: 203  ASYEL-----------QAGPEAQEL---FGLQVAEDQEEKQPQLIVMGNLDRERWDSYDL 248

Query: 656  GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
             ++  D GSPP +SS  + +TVLD NDN P F +P+YE  L+E++ +G SV+ ++A D D
Sbjct: 249  TIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSD 308

Query: 716  --ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GT--RS 770
              AN+ I Y         R  L   R  GLIT+  P+D +       +V A D GT  +S
Sbjct: 309  QGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKS 368

Query: 771  HTAHVLINVTDANTHRPVFQS------SHYT--VSVSEDRPVGTSIATLSANDEDTGENA 822
              A V++ V D N + P  +       +H     ++SED    T++A +  +D D GENA
Sbjct: 369  ARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENA 428

Query: 823  RITYVIQDPVP-QFRIDPDSGT-------MYTMMELDYENQVAYTLTIMAQDNGIPQKSD 874
             +T V+   VP Q R   ++G+       + T   LDYE    YT+ I+A D+G P  S 
Sbjct: 429  AVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSS 488

Query: 875  TTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGG 934
            T +L++ ++D NDNAP F     + +  E+  P   I +++A+D DSG N  L+Y+ +  
Sbjct: 489  TNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE 548

Query: 935  DDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIND 994
                G F I P +G I+ +  LDRE    Y L  +A DRGSP+ L  +  + V +LD ND
Sbjct: 549  PAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPS-LQGTATVLVNVLDCND 607

Query: 995  NAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE--GDMRHFFQLDLL 1052
            N P F        V EN P  S V  +   D D+G NAQ+   + +  GD    F +   
Sbjct: 608  NDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD----FVIQNG 663

Query: 1053 NGDLRAMVELDFEVRREYVLVVQATSAPLVSRAT---VHILLVDQNDNPPVLPDFQILFN 1109
             G + + +  D E +  Y   ++A    +  R+    V I ++D+NDN P +       +
Sbjct: 664  TGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSH 723

Query: 1110 NYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNN 1169
              +T ++    T         D  V+  L Y+   GN   L  +   +G + L ++++  
Sbjct: 724  KLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERR 783

Query: 1170 RPLEALMEVSVSD 1182
                  + V VSD
Sbjct: 784  HHGLHRLVVKVSD 796



 Score =  233 bits (594), Expect = 2e-60
 Identities = 177/567 (31%), Positives = 262/567 (46%), Gaps = 54/567 (9%)

Query: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
           KF  P+Y+  L EN P G  ++Q+ A+ + +G    + Y       E  R   R+D  TG
Sbjct: 279 KFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA-PEVVRRLLRLDRNTG 337

Query: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE--------Q 355
            ++    +DRE   T    V A D  T P+SA   + V VKD ND++P  E         
Sbjct: 338 LITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTH 397

Query: 356 SEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGV------- 408
            +    + E++     V  ++ SDRD   NA +   V G     FQL ++S         
Sbjct: 398 QDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDV--PFQLRQASETGSDSKKK 455

Query: 409 --VSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVV 466
             + T   LD E+  +Y + + A D G NP PLS+T ++ ++V D NDN P F++    V
Sbjct: 456 YFLQTTTPLDYEKVKDYTIEIVAVDSG-NP-PLSSTNSLKVQVVDVNDNAPVFTQSVTEV 513

Query: 467 QVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVA-GQFYLHSLSGILDVINPLDFE 525
             PE+      +  + A+D D G NA + YS+     A G F +   +G + V   LD E
Sbjct: 514 AFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDRE 573

Query: 526 DVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVV 585
             + Y L + A D G P L   +  V V VLD NDN+P F+ S +  +V+EN+P   PV 
Sbjct: 574 QRESYELKVVAADRGSPSL-QGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVG 632

Query: 586 HIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAEL 645
            +  +D D GENA++   +      F+                   I N +G I      
Sbjct: 633 MVTVIDGDKGENAQVQLSVEQDNGDFV-------------------IQNGTGTILSSLSF 673

Query: 646 DREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQP--TYELRLNEDAAVG 703
           DRE+   Y+F ++AVD G PP S+   V+I VLD NDN P  T P  T    L     +G
Sbjct: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLG 733

Query: 704 SSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLA 761
            +V  + A D D+  N+ + Y + GGN    F + S    G ITL   ++ +    + L 
Sbjct: 734 ETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSH--SGAITLEKEIERRHHGLHRLV 791

Query: 762 VTASDGTR-----SHTAHVLINVTDAN 783
           V  SD  +     +   H+ +N T AN
Sbjct: 792 VKVSDRGKPPRYGTALVHLYVNETLAN 818


>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
          Length = 1060

 Score =  291 bits (744), Expect = 9e-78
 Identities = 210/690 (30%), Positives = 330/690 (47%), Gaps = 58/690 (8%)

Query: 447  IEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQ 506
            IEV+D NDN P F+     + +PE+  + +      A+DRD G N    Y + +G  A +
Sbjct: 156  IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215

Query: 507  FY-------LHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVN 559
             +              L V+  LD E    Y L+IK QDGG PP   SS ++ V VLD N
Sbjct: 216  LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRA-SSALLRVTVLDTN 274

Query: 560  DNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGP 619
            DN P F    ++A + EN P+G+ V+ ++A D+D G NA + Y       TF        
Sbjct: 275  DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEY-------TF-------- 319

Query: 620  KNPAP-TPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVL 678
             + AP       ++  ++G ITV   +DRE++    F V A D G+ P S+   V +TV 
Sbjct: 320  -HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVK 378

Query: 679  DVNDNDP--------VFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGN 728
            D+NDN P        + T       ++ED A  ++V  +Q  DRD   N+ +T  +  G+
Sbjct: 379  DMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTC-VVAGD 437

Query: 729  TRNRFALSSQRGGG-----LITLALPLDYKQEQQYVLAVTASDGTR---SHTAHVLINVT 780
               +   +S+ G        +    PLDY++ + Y + + A D      S T  + + V 
Sbjct: 438  VPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVV 497

Query: 781  DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ----FR 836
            D N + PVF  S   V+  E+   G  IA ++A+D D+G NA + Y + +P P     F 
Sbjct: 498  DVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL-EPEPAAKGLFT 556

Query: 837  IDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDF 896
            I P++G +     LD E + +Y L ++A D G P    T T+ + +LD NDN P+F+   
Sbjct: 557  ISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSG 616

Query: 897  YQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRL 956
            Y  S+ E+ P  + +  V+  D D G N ++  +    +  +GDF I+  +G I +    
Sbjct: 617  YNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV---EQDNGDFVIQNGTGTILSSLSF 673

Query: 957  DRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF--EKDELELFVEENNPV 1014
            DRE  + Y     AVD G P P SA V + + +LD NDNAP      +     +     +
Sbjct: 674  DREQQSTYTFQLKAVDGGVP-PRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRL 732

Query: 1015 GSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVV 1074
            G  V+++ A D D G NA+++Y I  G+    FQ+   +G +    E++      + LVV
Sbjct: 733  GETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVV 792

Query: 1075 QAT---SAPLVSRATVHILLVDQNDNPPVL 1101
            + +     P    A VH+ + +   N  +L
Sbjct: 793  KVSDRGKPPRYGTALVHLYVNETLANRTLL 822



 Score =  279 bits (713), Expect = 3e-74
 Identities = 193/597 (32%), Positives = 291/597 (48%), Gaps = 47/597 (7%)

Query: 311 LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370
           LDRE  +++ L +K  D  +PPR+++  + V V DTND++P FE+  Y   + EN  +G+
Sbjct: 238 LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 297

Query: 371 EVLTIRASDRDSPINANLRYRVLGGAWDV---FQLNESSGVVSTRAVLDREEAAEYQLLV 427
            V+ ++A+D D   NA + Y        V    +L+ ++G+++ +  +DRE+ +  +  V
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSV 357

Query: 428 EANDQGRNPGPLSATATVYIEVEDENDNYPQF--------SEQNYVVQVPEDVGLNTAVL 479
            A D+G N  P SA A V + V+D NDN P          + Q+ +  + EDV   TAV 
Sbjct: 358 LAKDRGTN--PKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVA 415

Query: 480 RVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSG-------ILDVINPLDFEDVQKYSL 532
            VQ +DRD+G+NAA+   +++G+V  Q    S +G        L    PLD+E V+ Y++
Sbjct: 416 LVQVSDRDEGENAAV-TCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTI 474

Query: 533 SIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDA 592
            I A D G PPL +S+  + VQV+DVNDN P+F  S  +    EN   G  +  I A DA
Sbjct: 475 EIVAVDSGNPPL-SSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDA 533

Query: 593 DSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEH 652
           DSG NA L Y L                 P P     F I   +G I V   LDRE+ E 
Sbjct: 534 DSGSNAELVYSL----------------EPEPAAKGLFTISPETGEIQVKTSLDREQRES 577

Query: 653 YSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQAR 712
           Y   V A D GSP +  + +V + VLD NDNDP F    Y   + E+    S V  +   
Sbjct: 578 YELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVI 637

Query: 713 DRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TR 769
           D D       QL+       F +  Q G G I  +L  D +Q+  Y   + A DG    R
Sbjct: 638 DGDKGENAQVQLSVEQDNGDFVI--QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPR 695

Query: 770 SHTAHVLINVTDANTHRPVFQSSHYTVS--VSEDRPVGTSIATLSANDEDTGENARITYV 827
           S    V INV D N + P   +   T    ++    +G +++ ++A D D+G NA + Y 
Sbjct: 696 SAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS 755

Query: 828 IQ--DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILI 882
           I   +P   F+I   SG +    E++  +   + L +   D G P +  T  + + +
Sbjct: 756 IAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812



 Score =  270 bits (689), Expect = 2e-71
 Identities = 233/779 (29%), Positives = 347/779 (44%), Gaps = 102/779 (13%)

Query: 256 ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAV-STDSVLDRE 314
           E +P  TLI  L A Y                  E    Y R+D  TG + +T++ +DRE
Sbjct: 66  EEQPPNTLIGSLAADYGFPDVGHLYKL-------EVGAPYLRVDGKTGDIFTTETSIDRE 118

Query: 315 -TKETH----------VLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR 363
             +E               V   D             + V+D ND++P F        + 
Sbjct: 119 GLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIP 178

Query: 364 ENLEVGYEVLTIRASDRDSPINANLRYRVLGG--AWDVFQL------NESSGVVSTRAVL 415
           EN  +G       ASDRD+  N    Y +  G  A ++F L       E    +     L
Sbjct: 179 ENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNL 238

Query: 416 DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLN 475
           DRE    Y L ++  D G    P +++A + + V D NDN P+F   +Y  ++ E+  + 
Sbjct: 239 DRERWDSYDLTIKVQDGG--SPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIG 296

Query: 476 TAVLRVQATDRDQGQNAAIHYSILSGN--VAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
            +V++V+A D DQG NA I Y+       V     L   +G++ V  P+D ED+     S
Sbjct: 297 HSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFS 356

Query: 534 IKAQDGGRPPLINSSGVVSVQVLDVNDNEP--------IFVSSPFQATVLENVPLGYPVV 585
           + A+D G  P    + VV V V D+NDN P        +       A + E+V     V 
Sbjct: 357 VLAKDRGTNPKSARAQVV-VTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVA 415

Query: 586 HIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSG-------- 637
            +Q  D D GENA         A T +  G           D PFQ+  +S         
Sbjct: 416 LVQVSDRDEGENA---------AVTCVVAG-----------DVPFQLRQASETGSDSKKK 455

Query: 638 -WITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRL 696
            ++     LD E+V+ Y+  + AVD G+PP+SS+ S+ + V+DVNDN PVFTQ   E+  
Sbjct: 456 YFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAF 515

Query: 697 NEDAAVGSSVLTLQARDRD--ANSVITYQL-TGGNTRNRFALSSQRGGGLITLALPLDYK 753
            E+   G  +  + A D D  +N+ + Y L      +  F +S + G   I +   LD +
Sbjct: 516 PENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE--IQVKTSLDRE 573

Query: 754 QEQQYVLAVTASD-GTRS--HTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIAT 810
           Q + Y L V A+D G+ S   TA VL+NV D N + P F  S Y  SV E+ P  + +  
Sbjct: 574 QRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGM 633

Query: 811 LSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP 870
           ++  D D GENA++   ++     F I   +GT+ + +  D E Q  YT  + A D G+P
Sbjct: 634 VTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVP 693

Query: 871 QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTS-------------ILQVSAT 917
            +S    + I +LD NDNAP           +  AP +TS             + QV+A 
Sbjct: 694 PRSAYVGVTINVLDENDNAP-----------YITAPSNTSHKLLTPQTRLGETVSQVAAE 742

Query: 918 DRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSP 976
           D DSG N  L+Y+  GG+   G F I   SG I  ++ ++R +  ++ L     DRG P
Sbjct: 743 DFDSGVNAELIYSIAGGNP-YGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP 800



 Score =  266 bits (681), Expect = 2e-70
 Identities = 206/673 (30%), Positives = 312/673 (46%), Gaps = 53/673 (7%)

Query: 540  GRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENAR 599
            G P L+       ++V D+NDN P F S      + EN  +G       A D D+G N  
Sbjct: 147  GSPRLLEGQ----IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGV 202

Query: 600  LHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQI----HNSSGWITVCAELDREEVEHYSF 655
              Y L            AGP+       F  Q+          + V   LDRE  + Y  
Sbjct: 203  ASYEL-----------QAGPEAQEL---FGLQVAEDQEEKQPQLIVMGNLDRERWDSYDL 248

Query: 656  GVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715
             ++  D GSPP +SS  + +TVLD NDN P F +P+YE  L+E++ +G SV+ ++A D D
Sbjct: 249  TIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSD 308

Query: 716  --ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GT--RS 770
              AN+ I Y         R  L   R  GLIT+  P+D +       +V A D GT  +S
Sbjct: 309  QGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKS 368

Query: 771  HTAHVLINVTDANTHRPVFQS------SHYT--VSVSEDRPVGTSIATLSANDEDTGENA 822
              A V++ V D N + P  +       +H     ++SED    T++A +  +D D GENA
Sbjct: 369  ARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENA 428

Query: 823  RITYVIQDPVP-QFRIDPDSGT-------MYTMMELDYENQVAYTLTIMAQDNGIPQKSD 874
             +T V+   VP Q R   ++G+       + T   LDYE    YT+ I+A D+G P  S 
Sbjct: 429  AVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSS 488

Query: 875  TTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGG 934
            T +L++ ++D NDNAP F     + +  E+  P   I +++A+D DSG N  L+Y+ +  
Sbjct: 489  TNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPE 548

Query: 935  DDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIND 994
                G F I P +G I+ +  LDRE    Y L  +A DRGSP+ L  +  + V +LD ND
Sbjct: 549  PAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPS-LQGTATVLVNVLDCND 607

Query: 995  NAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE--GDMRHFFQLDLL 1052
            N P F        V EN P  S V  +   D D+G NAQ+   + +  GD    F +   
Sbjct: 608  NDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD----FVIQNG 663

Query: 1053 NGDLRAMVELDFEVRREYVLVVQATSAPLVSRAT---VHILLVDQNDNPPVLPDFQILFN 1109
             G + + +  D E +  Y   ++A    +  R+    V I ++D+NDN P +       +
Sbjct: 664  TGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSH 723

Query: 1110 NYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNN 1169
              +T ++    T         D  V+  L Y+   GN   L  +   +G + L ++++  
Sbjct: 724  KLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERR 783

Query: 1170 RPLEALMEVSVSD 1182
                  + V VSD
Sbjct: 784  HHGLHRLVVKVSD 796



 Score =  233 bits (594), Expect = 2e-60
 Identities = 177/567 (31%), Positives = 262/567 (46%), Gaps = 54/567 (9%)

Query: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
           KF  P+Y+  L EN P G  ++Q+ A+ + +G    + Y       E  R   R+D  TG
Sbjct: 279 KFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA-PEVVRRLLRLDRNTG 337

Query: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE--------Q 355
            ++    +DRE   T    V A D  T P+SA   + V VKD ND++P  E         
Sbjct: 338 LITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTH 397

Query: 356 SEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGV------- 408
            +    + E++     V  ++ SDRD   NA +   V G     FQL ++S         
Sbjct: 398 QDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDV--PFQLRQASETGSDSKKK 455

Query: 409 --VSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVV 466
             + T   LD E+  +Y + + A D G NP PLS+T ++ ++V D NDN P F++    V
Sbjct: 456 YFLQTTTPLDYEKVKDYTIEIVAVDSG-NP-PLSSTNSLKVQVVDVNDNAPVFTQSVTEV 513

Query: 467 QVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVA-GQFYLHSLSGILDVINPLDFE 525
             PE+      +  + A+D D G NA + YS+     A G F +   +G + V   LD E
Sbjct: 514 AFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDRE 573

Query: 526 DVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVV 585
             + Y L + A D G P L   +  V V VLD NDN+P F+ S +  +V+EN+P   PV 
Sbjct: 574 QRESYELKVVAADRGSPSL-QGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVG 632

Query: 586 HIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAEL 645
            +  +D D GENA++   +      F+                   I N +G I      
Sbjct: 633 MVTVIDGDKGENAQVQLSVEQDNGDFV-------------------IQNGTGTILSSLSF 673

Query: 646 DREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQP--TYELRLNEDAAVG 703
           DRE+   Y+F ++AVD G PP S+   V+I VLD NDN P  T P  T    L     +G
Sbjct: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLG 733

Query: 704 SSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLA 761
            +V  + A D D+  N+ + Y + GGN    F + S    G ITL   ++ +    + L 
Sbjct: 734 ETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSH--SGAITLEKEIERRHHGLHRLV 791

Query: 762 VTASDGTR-----SHTAHVLINVTDAN 783
           V  SD  +     +   H+ +N T AN
Sbjct: 792 VKVSDRGKPPRYGTALVHLYVNETLAN 818


>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
          Length = 1203

 Score =  288 bits (738), Expect = 4e-77
 Identities = 214/729 (29%), Positives = 357/729 (48%), Gaps = 55/729 (7%)

Query: 359  RERVRENLEVGY--EVLTIRASDRDSPINANLRYRVLGGAWD--VFQLNESSG-VVSTRA 413
            RE + EN+ +G   + L I   +  +  +A+L YR++  A D  + +++ S+G + +T  
Sbjct: 31   REELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSN 90

Query: 414  VLDREEAAEYQLLVEANDQGRN------PGPLSATATVYIEVEDENDNYPQFSEQNYVVQ 467
             +DRE+        E N+          P        + I V+D NDN P F      + 
Sbjct: 91   RIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINIS 150

Query: 468  VPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSG-NVAGQFYLHSLSGI----LDVINPL 522
            +PE+  +N+      ATD D G N   HY +L+G +V G   + +  G     L V   L
Sbjct: 151  IPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNL 210

Query: 523  DFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGY 582
            D E    Y + IK +DGG P   +S+ ++ V V DVNDN P+F     +  + EN P+G 
Sbjct: 211  DREQKDTYVMKIKVEDGGTPQK-SSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGT 269

Query: 583  PVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVC 642
             V+ + A DAD G NA + Y         + G        AP     F ++N++G ITV 
Sbjct: 270  SVIQLHATDADIGSNAEIRY---------IFGAQV-----APATKRLFALNNTTGLITVQ 315

Query: 643  AELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDP------VFTQPTYELRL 696
              LDREE   +   V A D  S P  ++ ++++T  DVNDN P      + +     + L
Sbjct: 316  RSLDREETAIHKVTVLASDGSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGTVYL 373

Query: 697  NEDAAVGSSV--LTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQ 754
            +E   V + +  +T+  +D D N  +   +      +  A+   +   L+  +  LDY+ 
Sbjct: 374  SEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQY--LLETSSLLDYEG 431

Query: 755  EQQYVLAVTASDGTR---SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATL 811
             +++   + ASD  +   + TA V + + D N + P+F      +SVSE+   G  + T+
Sbjct: 432  TKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTI 491

Query: 812  SANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQ 871
            SA DED+G+NA I Y +      F +D  +G +      D E Q  +  T+ A+DNG P 
Sbjct: 492  SATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP 551

Query: 872  KSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTF 931
                  + + +LD NDN+P+F  + +Q  + E+ P  +++  ++ TD D+G N  +  + 
Sbjct: 552  LQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSI 611

Query: 932  QGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILD 991
               +D   +F ++P SGVI++    DRE  + Y     A D G P P S++ ++ + ++D
Sbjct: 612  LNDND---NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP-PRSSTAKVTINVMD 667

Query: 992  INDNAPMF----EKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFF 1047
            +NDN+P+          +L      P GSVVA++ A D D G NA++ Y IV G+ +  F
Sbjct: 668  VNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLF 726

Query: 1048 QLDLLNGDL 1056
            ++D + G++
Sbjct: 727  RIDPVTGNI 735



 Score =  264 bits (675), Expect = 9e-70
 Identities = 203/687 (29%), Positives = 327/687 (47%), Gaps = 62/687 (9%)

Query: 339 ITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD 398
           I ++VKDTND++P+F        + EN  +        A+D D+  N    Y +L G   
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQ-S 186

Query: 399 VFQLN-------ESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVED 451
           VF L+       E    +  +  LDRE+   Y + ++  D G      S+TA + + V D
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQK--SSTAILQVTVSD 244

Query: 452 ENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQ----F 507
            NDN P F E    V +PE+  + T+V+++ ATD D G NA I Y I    VA      F
Sbjct: 245 VNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRY-IFGAQVAPATKRLF 303

Query: 508 YLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI--- 564
            L++ +G++ V   LD E+   + +++ A DG   P   +   V++ V DVNDN P    
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP---ARATVTINVTDVNDNPPNIDL 360

Query: 565 -FVSSPFQATVL--ENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKN 621
            ++ SP   TV   E  P+   +  I   D D+  N ++   +                 
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI----------------- 403

Query: 622 PAPTPDFPFQ---IHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVL 678
                + PF    ++++   +   + LD E  + +SF + A D G P ++ +  V + + 
Sbjct: 404 ---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLE 460

Query: 679 DVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALS 736
           D NDN P+F QP  EL ++E+   G  + T+ A D D+  N+ I YQL  G   + F L 
Sbjct: 461 DENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLD 518

Query: 737 SQRGGGLITLALPLDYKQEQQYVLAVTASD-GTR--SHTAHVLINVTDANTHRPVFQSSH 793
             R  G++T +   D +++++++  VTA D GT      A V++ V D N + P F  +H
Sbjct: 519 --RKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNH 576

Query: 794 YTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYE 853
           +   VSE+ P  +++  ++  D D GEN  +T  I +    F +DP SG + + +  D E
Sbjct: 577 FQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDRE 636

Query: 854 NQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAP----PST 909
            Q +YT  + A D G P +S T  + I ++D NDN+P  +      S F+  P    P +
Sbjct: 637 QQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FKLVPLSAIPGS 695

Query: 910 SILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWAL 969
            + +V A D D+G N  L YT   G++  G F I+P +G I  + +    +V ++ L   
Sbjct: 696 VVAEVFAVDVDTGMNAELKYTIVSGNN-KGLFRIDPVTGNITLEEKPAPTDVGLHRLVVN 754

Query: 970 AVDRGSPTPLSASVEIQVTILDINDNA 996
             D G P  L   V + + + D   NA
Sbjct: 755 ISDLGYPKSLHTLVLVFLYVNDTAGNA 781



 Score =  262 bits (669), Expect = 4e-69
 Identities = 195/604 (32%), Positives = 291/604 (48%), Gaps = 46/604 (7%)

Query: 311 LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370
           LDRE K+T+V+++K  D  TP +S+T  + V V D ND+ PVF++ +    + EN  VG 
Sbjct: 210 LDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGT 269

Query: 371 EVLTIRASDRDSPINANLRY----RVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLL 426
            V+ + A+D D   NA +RY    +V      +F LN ++G+++ +  LDREE A +++ 
Sbjct: 270 SVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVT 329

Query: 427 VEANDQGRNPGPLSATATVYIEVEDENDNYPQ------FSEQNYVVQVPEDVGLNTAVLR 480
           V A+D    P    A ATV I V D NDN P        S  N  V + E   +NT +  
Sbjct: 330 VLASDGSSTP----ARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIAL 385

Query: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG 540
           +  +D+D   N  +   I          ++    +L+  + LD+E  +++S  I A D G
Sbjct: 386 ITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSG 445

Query: 541 RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARL 600
           +P L N + +V V++ D NDN PIF     + +V EN   G  +  I A D DSG+NA +
Sbjct: 446 KPSL-NQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504

Query: 601 HYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAV 660
            Y+L   AS                    F +   +G +T     DREE E + F V A 
Sbjct: 505 VYQLGPNASF-------------------FDLDRKTGVLTASRVFDREEQERFIFTVTAR 545

Query: 661 DHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVI 720
           D+G+PP+ S  +V +TVLD NDN P FT   ++  ++E+    S+V  +   D DA    
Sbjct: 546 DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605

Query: 721 TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLI 777
              L+  N  + F L      G+I   +  D +Q+  Y   V A+DG    RS TA V I
Sbjct: 606 AVTLSILNDNDNFVLDPY--SGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTI 663

Query: 778 NVTDANTHRPVFQSSHYTVS---VSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ 834
           NV D N + PV  S     S   V      G+ +A + A D DTG NA + Y I     +
Sbjct: 664 NVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNK 723

Query: 835 --FRIDPDSGTMYTMMELDYENQVA-YTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891
             FRIDP +G + T+ E      V  + L +   D G P+   T  L  L ++       
Sbjct: 724 GLFRIDPVTGNI-TLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNAS 782

Query: 892 FLWD 895
           +++D
Sbjct: 783 YIYD 786



 Score =  260 bits (665), Expect = 1e-68
 Identities = 206/636 (32%), Positives = 304/636 (47%), Gaps = 50/636 (7%)

Query: 551  VSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAST 610
            + + V D NDN P+F S     ++ EN  +        A D D+G N   HY L++  S 
Sbjct: 128  IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187

Query: 611  FLGGGSAGPKNPAPTPDFPFQIHNSSGW--ITVCAELDREEVEHYSFGVEAVDHGSPPMS 668
            F         +   TP+          W  + V   LDRE+ + Y   ++  D G+P  S
Sbjct: 188  F-------GLDIVETPE-------GEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKS 233

Query: 669  SSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQL-- 724
            S+  + +TV DVNDN PVF +   E+ + E+A VG+SV+ L A D D  +N+ I Y    
Sbjct: 234  STAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGA 293

Query: 725  -TGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHT-AHVLINVTDA 782
                 T+  FAL++  G  LIT+   LD ++   + + V ASDG+ +   A V INVTD 
Sbjct: 294  QVAPATKRLFALNNTTG--LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDV 351

Query: 783  NTHRP------VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFR 836
            N + P      +    + TV +SE  PV T IA ++ +D+DT  N ++   I+  VP F 
Sbjct: 352  NDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP-FH 410

Query: 837  IDPDSGTMY---TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
            +       Y   T   LDYE    ++  I+A D+G P  + T  + + + D NDN P F 
Sbjct: 411  LKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFN 470

Query: 894  WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ 953
                + S+ E+      +  +SATD DSG N  ++Y  Q G +    F ++  +GV+   
Sbjct: 471  QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY--QLGPNASF-FDLDRKTGVLTAS 527

Query: 954  RRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNP 1013
            R  DRE    +     A D G+P PL +   + VT+LD NDN+P F  +  + FV EN P
Sbjct: 528  RVFDREEQERFIFTVTARDNGTP-PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLP 586

Query: 1014 VGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLV 1073
              S V  I   D D G N  +   I+  +    F LD  +G +++ V  D E +  Y   
Sbjct: 587  KYSTVGVITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFD 644

Query: 1074 VQATSA---PLVSRATVHILLVDQNDNPPVL--PDFQILFNNYVTNKSNSFPTGVIGCIP 1128
            V+AT     P  S A V I ++D NDN PV+  P     F     +   + P  V+  + 
Sbjct: 645  VKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS---AIPGSVVAEVF 701

Query: 1129 AHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQL 1162
            A D D  ++  L YT V GN   L  +DP TG + L
Sbjct: 702  AVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737



 Score =  214 bits (546), Expect = 8e-55
 Identities = 192/693 (27%), Positives = 307/693 (44%), Gaps = 50/693 (7%)

Query: 576  ENVPLGY--PVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIH 633
            ENVP+G     ++I  ++A +G +A L YRLV  A      G A     + +    F   
Sbjct: 36   ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKA------GDAPLVKVSSSTGEIFTTS 89

Query: 634  NSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYE 693
            N      +CA     E     F +E V   +        + I V D NDN P+F  P   
Sbjct: 90   NRIDREKLCAGASYAEENECFFELEVVILPND-FFRLIKIKIIVKDTNDNAPMFPSPVIN 148

Query: 694  LRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGL---ITLAL 748
            + + E+  + S      A D D   N V  Y+L  G +     +     G     + +  
Sbjct: 149  ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQ 208

Query: 749  PLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVG 805
             LD +Q+  YV+ +   DG    +S TA + + V+D N +RPVF+     V + E+ PVG
Sbjct: 209  NLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVG 268

Query: 806  TSIATLSANDEDTGENARITYVIQDPVPQ-----FRIDPDSGTMYTMMELDYENQVAYTL 860
            TS+  L A D D G NA I Y+    V       F ++  +G +     LD E    + +
Sbjct: 269  TSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKV 328

Query: 861  TIMAQDNGIPQKSDTTTLEILILDANDNAP----QFLWDFYQGSIF--EDAPPSTSILQV 914
            T++A D        T T+ +   D NDN P    +++     G+++  E  P +T I  +
Sbjct: 329  TVLASDGSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALI 386

Query: 915  SATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG---VIRTQRRLDRENVAVYNLWALAV 971
            + +D+D+  NG+++   +     +  F+++       ++ T   LD E    ++   +A 
Sbjct: 387  TVSDKDTDVNGKVICFIER----EVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVAS 442

Query: 972  DRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPN 1031
            D G P+ L+ +  ++V + D NDN P+F +  +EL V ENN  G  +  I A D D G N
Sbjct: 443  DSGKPS-LNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKN 501

Query: 1032 AQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQAT---SAPLVSRATVH 1088
            A I+YQ+  G    FF LD   G L A    D E +  ++  V A    + PL S+A V 
Sbjct: 502  ADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVI 559

Query: 1089 ILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT-GVIGCIPAHDPDVSDSLNYTFVQGNE 1147
            + ++D+NDN P     +   N++    S + P    +G I   D D  ++   T    N+
Sbjct: 560  VTVLDENDNSP-----KFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILND 614

Query: 1148 LRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSI 1207
                +LDP +G ++ +   D  +      +V  +DG     +  T +VTI   D+  NS 
Sbjct: 615  NDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRS-STAKVTINVMDVNDNSP 673

Query: 1208 TVRLENMSQEKFLSPLLALFVEGVAAVLSTTKD 1240
             V     +    L PL A+    VA V +   D
Sbjct: 674  VVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVD 706



 Score =  204 bits (519), Expect = 1e-51
 Identities = 168/574 (29%), Positives = 257/574 (44%), Gaps = 45/574 (7%)

Query: 251 QVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSV 310
           +V + EN P GT ++QLHA     G    + Y         ++  F +++ TG ++    
Sbjct: 258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRS 317

Query: 311 LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSP------VFEQSEYRERVRE 364
           LDRE    H + V A D S+ P  AT  +T+ V D ND+ P      +         + E
Sbjct: 318 LDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYIISPINGTVYLSE 375

Query: 365 NLEVGYEVLTIRASDRDSPINAN-LRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
              V  ++  I  SD+D+ +N   + +      + +  + ++  ++ T ++LD E   E+
Sbjct: 376 KDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435

Query: 424 QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQA 483
              + A+D G+    L+ TA V +++EDENDN P F++    + V E+      +  + A
Sbjct: 436 SFKIVASDSGK--PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISA 493

Query: 484 TDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPP 543
           TD D G+NA I Y +  G  A  F L   +G+L      D E+ +++  ++ A+D G PP
Sbjct: 494 TDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP 551

Query: 544 LINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYR 603
           L  S   V V VLD NDN P F  + FQ  V EN+P    V  I   DAD+GEN  +   
Sbjct: 552 L-QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLS 610

Query: 604 LVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG 663
           +++    F+                   +   SG I      DRE+   Y+F V+A D G
Sbjct: 611 ILNDNDNFV-------------------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651

Query: 664 SPPMSSSTSVSITVLDVNDNDPVFTQP---TYELRLNEDAAVGSSVLTLQARDRDA--NS 718
            PP SS+  V+I V+DVNDN PV   P   T    +   A  GS V  + A D D   N+
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711

Query: 719 VITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLIN 778
            + Y +  GN +  F +    G   ITL           + L V  SD     + H L+ 
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN--ITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVL 769

Query: 779 V-----TDANTHRPVFQSSHYTVSVSEDRPVGTS 807
           V       A     ++     T+    DR +G S
Sbjct: 770 VFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDS 803



 Score =  171 bits (434), Expect = 8e-42
 Identities = 127/395 (32%), Positives = 190/395 (48%), Gaps = 36/395 (9%)

Query: 249 NYQVALFENEPAGT---LILQLHAHYTIEGE-----EERVSYYMEGLFDERSRGYFRIDS 300
           N  V L E +P  T   LI        + G+     E  V ++++ ++D +         
Sbjct: 368 NGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQY-------- 419

Query: 301 ATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE 360
               + T S+LD E  +    ++ A D   P  + T  + V ++D ND+ P+F Q     
Sbjct: 420 ---LLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476

Query: 361 RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEA 420
            V EN   G  + TI A+D DS  NA++ Y+ LG     F L+  +GV++   V DREE 
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQ-LGPNASFFDLDRKTGVLTASRVFDREEQ 535

Query: 421 AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480
             +   V A D G    PL + A V + V DENDN P+F+  ++   V E++   + V  
Sbjct: 536 ERFIFTVTARDNG--TPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593

Query: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG 540
           +  TD D G+N A+  SIL+ N    F L   SG++      D E    Y+  +KA DGG
Sbjct: 594 ITVTDADAGENKAVTLSILNDN--DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651

Query: 541 RPPLINSSGVVSVQVLDVNDNEPIFVSSP----FQATVLENVPLGYPVVHIQAVDADSGE 596
           +PP  +S+  V++ V+DVNDN P+ +S P    F+   L  +P G  V  + AVD D+G 
Sbjct: 652 QPPR-SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGM 709

Query: 597 NARLHYRLVDTASTFL------GGGSAGPKNPAPT 625
           NA L Y +V   +  L       G     + PAPT
Sbjct: 710 NAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPT 744



 Score =  122 bits (307), Expect = 4e-27
 Identities = 96/321 (29%), Positives = 149/321 (46%), Gaps = 13/321 (4%)

Query: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
           F  P  ++++ EN   G  +  + A     G+   + Y +       +  +F +D  TG 
Sbjct: 469 FNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP-----NASFFDLDRKTGV 523

Query: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
           ++   V DRE +E  +  V A D  TPP  +   + V V D ND+SP F  + ++  V E
Sbjct: 524 LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583

Query: 365 NLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQ 424
           NL     V  I  +D D+  N  +   +L    D F L+  SGV+ +    DRE+ + Y 
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDN-DNFVLDPYSGVIKSNVSFDREQQSSYT 642

Query: 425 LLVEANDQGRNPGPLSATATVYIEVEDENDNYPQF----SEQNYVVQVPEDVGLNTAVLR 480
             V+A D G+   P S+TA V I V D NDN P      S  ++ + VP      + V  
Sbjct: 643 FDVKATDGGQ--PPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL-VPLSAIPGSVVAE 699

Query: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG 540
           V A D D G NA + Y+I+SGN  G F +  ++G + +       DV  + L +   D G
Sbjct: 700 VFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLG 759

Query: 541 RPPLINSSGVVSVQVLDVNDN 561
            P  +++  +V + V D   N
Sbjct: 760 YPKSLHTLVLVFLYVNDTAGN 780


>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
          Length = 1237

 Score =  288 bits (738), Expect = 4e-77
 Identities = 214/729 (29%), Positives = 357/729 (48%), Gaps = 55/729 (7%)

Query: 359  RERVRENLEVGY--EVLTIRASDRDSPINANLRYRVLGGAWD--VFQLNESSG-VVSTRA 413
            RE + EN+ +G   + L I   +  +  +A+L YR++  A D  + +++ S+G + +T  
Sbjct: 31   REELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSN 90

Query: 414  VLDREEAAEYQLLVEANDQGRN------PGPLSATATVYIEVEDENDNYPQFSEQNYVVQ 467
             +DRE+        E N+          P        + I V+D NDN P F      + 
Sbjct: 91   RIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINIS 150

Query: 468  VPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSG-NVAGQFYLHSLSGI----LDVINPL 522
            +PE+  +N+      ATD D G N   HY +L+G +V G   + +  G     L V   L
Sbjct: 151  IPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNL 210

Query: 523  DFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGY 582
            D E    Y + IK +DGG P   +S+ ++ V V DVNDN P+F     +  + EN P+G 
Sbjct: 211  DREQKDTYVMKIKVEDGGTPQK-SSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGT 269

Query: 583  PVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVC 642
             V+ + A DAD G NA + Y         + G        AP     F ++N++G ITV 
Sbjct: 270  SVIQLHATDADIGSNAEIRY---------IFGAQV-----APATKRLFALNNTTGLITVQ 315

Query: 643  AELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDP------VFTQPTYELRL 696
              LDREE   +   V A D  S P  ++ ++++T  DVNDN P      + +     + L
Sbjct: 316  RSLDREETAIHKVTVLASDGSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGTVYL 373

Query: 697  NEDAAVGSSV--LTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQ 754
            +E   V + +  +T+  +D D N  +   +      +  A+   +   L+  +  LDY+ 
Sbjct: 374  SEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQY--LLETSSLLDYEG 431

Query: 755  EQQYVLAVTASDGTR---SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATL 811
             +++   + ASD  +   + TA V + + D N + P+F      +SVSE+   G  + T+
Sbjct: 432  TKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTI 491

Query: 812  SANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQ 871
            SA DED+G+NA I Y +      F +D  +G +      D E Q  +  T+ A+DNG P 
Sbjct: 492  SATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP 551

Query: 872  KSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTF 931
                  + + +LD NDN+P+F  + +Q  + E+ P  +++  ++ TD D+G N  +  + 
Sbjct: 552  LQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSI 611

Query: 932  QGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILD 991
               +D   +F ++P SGVI++    DRE  + Y     A D G P P S++ ++ + ++D
Sbjct: 612  LNDND---NFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP-PRSSTAKVTINVMD 667

Query: 992  INDNAPMF----EKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFF 1047
            +NDN+P+          +L      P GSVVA++ A D D G NA++ Y IV G+ +  F
Sbjct: 668  VNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLF 726

Query: 1048 QLDLLNGDL 1056
            ++D + G++
Sbjct: 727  RIDPVTGNI 735



 Score =  264 bits (675), Expect = 9e-70
 Identities = 203/687 (29%), Positives = 327/687 (47%), Gaps = 62/687 (9%)

Query: 339 ITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD 398
           I ++VKDTND++P+F        + EN  +        A+D D+  N    Y +L G   
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQ-S 186

Query: 399 VFQLN-------ESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVED 451
           VF L+       E    +  +  LDRE+   Y + ++  D G      S+TA + + V D
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQK--SSTAILQVTVSD 244

Query: 452 ENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQ----F 507
            NDN P F E    V +PE+  + T+V+++ ATD D G NA I Y I    VA      F
Sbjct: 245 VNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRY-IFGAQVAPATKRLF 303

Query: 508 YLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI--- 564
            L++ +G++ V   LD E+   + +++ A DG   P   +   V++ V DVNDN P    
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP---ARATVTINVTDVNDNPPNIDL 360

Query: 565 -FVSSPFQATVL--ENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKN 621
            ++ SP   TV   E  P+   +  I   D D+  N ++   +                 
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI----------------- 403

Query: 622 PAPTPDFPFQ---IHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVL 678
                + PF    ++++   +   + LD E  + +SF + A D G P ++ +  V + + 
Sbjct: 404 ---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLE 460

Query: 679 DVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALS 736
           D NDN P+F QP  EL ++E+   G  + T+ A D D+  N+ I YQL  G   + F L 
Sbjct: 461 DENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLD 518

Query: 737 SQRGGGLITLALPLDYKQEQQYVLAVTASD-GTR--SHTAHVLINVTDANTHRPVFQSSH 793
             R  G++T +   D +++++++  VTA D GT      A V++ V D N + P F  +H
Sbjct: 519 --RKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNH 576

Query: 794 YTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYE 853
           +   VSE+ P  +++  ++  D D GEN  +T  I +    F +DP SG + + +  D E
Sbjct: 577 FQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDRE 636

Query: 854 NQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAP----PST 909
            Q +YT  + A D G P +S T  + I ++D NDN+P  +      S F+  P    P +
Sbjct: 637 QQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FKLVPLSAIPGS 695

Query: 910 SILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWAL 969
            + +V A D D+G N  L YT   G++  G F I+P +G I  + +    +V ++ L   
Sbjct: 696 VVAEVFAVDVDTGMNAELKYTIVSGNN-KGLFRIDPVTGNITLEEKPAPTDVGLHRLVVN 754

Query: 970 AVDRGSPTPLSASVEIQVTILDINDNA 996
             D G P  L   V + + + D   NA
Sbjct: 755 ISDLGYPKSLHTLVLVFLYVNDTAGNA 781



 Score =  262 bits (669), Expect = 4e-69
 Identities = 195/604 (32%), Positives = 291/604 (48%), Gaps = 46/604 (7%)

Query: 311 LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370
           LDRE K+T+V+++K  D  TP +S+T  + V V D ND+ PVF++ +    + EN  VG 
Sbjct: 210 LDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGT 269

Query: 371 EVLTIRASDRDSPINANLRY----RVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLL 426
            V+ + A+D D   NA +RY    +V      +F LN ++G+++ +  LDREE A +++ 
Sbjct: 270 SVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVT 329

Query: 427 VEANDQGRNPGPLSATATVYIEVEDENDNYPQ------FSEQNYVVQVPEDVGLNTAVLR 480
           V A+D    P    A ATV I V D NDN P        S  N  V + E   +NT +  
Sbjct: 330 VLASDGSSTP----ARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIAL 385

Query: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG 540
           +  +D+D   N  +   I          ++    +L+  + LD+E  +++S  I A D G
Sbjct: 386 ITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSG 445

Query: 541 RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARL 600
           +P L N + +V V++ D NDN PIF     + +V EN   G  +  I A D DSG+NA +
Sbjct: 446 KPSL-NQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504

Query: 601 HYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAV 660
            Y+L   AS                    F +   +G +T     DREE E + F V A 
Sbjct: 505 VYQLGPNASF-------------------FDLDRKTGVLTASRVFDREEQERFIFTVTAR 545

Query: 661 DHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVI 720
           D+G+PP+ S  +V +TVLD NDN P FT   ++  ++E+    S+V  +   D DA    
Sbjct: 546 DNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENK 605

Query: 721 TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLI 777
              L+  N  + F L      G+I   +  D +Q+  Y   V A+DG    RS TA V I
Sbjct: 606 AVTLSILNDNDNFVLDPY--SGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTI 663

Query: 778 NVTDANTHRPVFQSSHYTVS---VSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ 834
           NV D N + PV  S     S   V      G+ +A + A D DTG NA + Y I     +
Sbjct: 664 NVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNK 723

Query: 835 --FRIDPDSGTMYTMMELDYENQVA-YTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891
             FRIDP +G + T+ E      V  + L +   D G P+   T  L  L ++       
Sbjct: 724 GLFRIDPVTGNI-TLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNAS 782

Query: 892 FLWD 895
           +++D
Sbjct: 783 YIYD 786



 Score =  260 bits (665), Expect = 1e-68
 Identities = 206/636 (32%), Positives = 304/636 (47%), Gaps = 50/636 (7%)

Query: 551  VSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAST 610
            + + V D NDN P+F S     ++ EN  +        A D D+G N   HY L++  S 
Sbjct: 128  IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187

Query: 611  FLGGGSAGPKNPAPTPDFPFQIHNSSGW--ITVCAELDREEVEHYSFGVEAVDHGSPPMS 668
            F         +   TP+          W  + V   LDRE+ + Y   ++  D G+P  S
Sbjct: 188  F-------GLDIVETPE-------GEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKS 233

Query: 669  SSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQL-- 724
            S+  + +TV DVNDN PVF +   E+ + E+A VG+SV+ L A D D  +N+ I Y    
Sbjct: 234  STAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGA 293

Query: 725  -TGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHT-AHVLINVTDA 782
                 T+  FAL++  G  LIT+   LD ++   + + V ASDG+ +   A V INVTD 
Sbjct: 294  QVAPATKRLFALNNTTG--LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDV 351

Query: 783  NTHRP------VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFR 836
            N + P      +    + TV +SE  PV T IA ++ +D+DT  N ++   I+  VP F 
Sbjct: 352  NDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVP-FH 410

Query: 837  IDPDSGTMY---TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
            +       Y   T   LDYE    ++  I+A D+G P  + T  + + + D NDN P F 
Sbjct: 411  LKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFN 470

Query: 894  WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ 953
                + S+ E+      +  +SATD DSG N  ++Y  Q G +    F ++  +GV+   
Sbjct: 471  QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY--QLGPNASF-FDLDRKTGVLTAS 527

Query: 954  RRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNP 1013
            R  DRE    +     A D G+P PL +   + VT+LD NDN+P F  +  + FV EN P
Sbjct: 528  RVFDREEQERFIFTVTARDNGTP-PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLP 586

Query: 1014 VGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLV 1073
              S V  I   D D G N  +   I+  +    F LD  +G +++ V  D E +  Y   
Sbjct: 587  KYSTVGVITVTDADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFD 644

Query: 1074 VQATSA---PLVSRATVHILLVDQNDNPPVL--PDFQILFNNYVTNKSNSFPTGVIGCIP 1128
            V+AT     P  S A V I ++D NDN PV+  P     F     +   + P  V+  + 
Sbjct: 645  VKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS---AIPGSVVAEVF 701

Query: 1129 AHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQL 1162
            A D D  ++  L YT V GN   L  +DP TG + L
Sbjct: 702  AVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737



 Score =  214 bits (546), Expect = 8e-55
 Identities = 192/693 (27%), Positives = 307/693 (44%), Gaps = 50/693 (7%)

Query: 576  ENVPLGY--PVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIH 633
            ENVP+G     ++I  ++A +G +A L YRLV  A      G A     + +    F   
Sbjct: 36   ENVPIGNIPKDLNISHINAATGTSASLVYRLVSKA------GDAPLVKVSSSTGEIFTTS 89

Query: 634  NSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYE 693
            N      +CA     E     F +E V   +        + I V D NDN P+F  P   
Sbjct: 90   NRIDREKLCAGASYAEENECFFELEVVILPND-FFRLIKIKIIVKDTNDNAPMFPSPVIN 148

Query: 694  LRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGL---ITLAL 748
            + + E+  + S      A D D   N V  Y+L  G +     +     G     + +  
Sbjct: 149  ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQ 208

Query: 749  PLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVG 805
             LD +Q+  YV+ +   DG    +S TA + + V+D N +RPVF+     V + E+ PVG
Sbjct: 209  NLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVG 268

Query: 806  TSIATLSANDEDTGENARITYVIQDPVPQ-----FRIDPDSGTMYTMMELDYENQVAYTL 860
            TS+  L A D D G NA I Y+    V       F ++  +G +     LD E    + +
Sbjct: 269  TSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKV 328

Query: 861  TIMAQDNGIPQKSDTTTLEILILDANDNAP----QFLWDFYQGSIF--EDAPPSTSILQV 914
            T++A D        T T+ +   D NDN P    +++     G+++  E  P +T I  +
Sbjct: 329  TVLASDGSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALI 386

Query: 915  SATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG---VIRTQRRLDRENVAVYNLWALAV 971
            + +D+D+  NG+++   +     +  F+++       ++ T   LD E    ++   +A 
Sbjct: 387  TVSDKDTDVNGKVICFIER----EVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVAS 442

Query: 972  DRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPN 1031
            D G P+ L+ +  ++V + D NDN P+F +  +EL V ENN  G  +  I A D D G N
Sbjct: 443  DSGKPS-LNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKN 501

Query: 1032 AQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQAT---SAPLVSRATVH 1088
            A I+YQ+  G    FF LD   G L A    D E +  ++  V A    + PL S+A V 
Sbjct: 502  ADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVI 559

Query: 1089 ILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT-GVIGCIPAHDPDVSDSLNYTFVQGNE 1147
            + ++D+NDN P     +   N++    S + P    +G I   D D  ++   T    N+
Sbjct: 560  VTVLDENDNSP-----KFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILND 614

Query: 1148 LRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSI 1207
                +LDP +G ++ +   D  +      +V  +DG     +  T +VTI   D+  NS 
Sbjct: 615  NDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRS-STAKVTINVMDVNDNSP 673

Query: 1208 TVRLENMSQEKFLSPLLALFVEGVAAVLSTTKD 1240
             V     +    L PL A+    VA V +   D
Sbjct: 674  VVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVD 706



 Score =  204 bits (519), Expect = 1e-51
 Identities = 168/574 (29%), Positives = 257/574 (44%), Gaps = 45/574 (7%)

Query: 251 QVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSV 310
           +V + EN P GT ++QLHA     G    + Y         ++  F +++ TG ++    
Sbjct: 258 EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRS 317

Query: 311 LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSP------VFEQSEYRERVRE 364
           LDRE    H + V A D S+ P  AT  +T+ V D ND+ P      +         + E
Sbjct: 318 LDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYIISPINGTVYLSE 375

Query: 365 NLEVGYEVLTIRASDRDSPINAN-LRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEY 423
              V  ++  I  SD+D+ +N   + +      + +  + ++  ++ T ++LD E   E+
Sbjct: 376 KDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435

Query: 424 QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQA 483
              + A+D G+    L+ TA V +++EDENDN P F++    + V E+      +  + A
Sbjct: 436 SFKIVASDSGK--PSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISA 493

Query: 484 TDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPP 543
           TD D G+NA I Y +  G  A  F L   +G+L      D E+ +++  ++ A+D G PP
Sbjct: 494 TDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP 551

Query: 544 LINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYR 603
           L  S   V V VLD NDN P F  + FQ  V EN+P    V  I   DAD+GEN  +   
Sbjct: 552 L-QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLS 610

Query: 604 LVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG 663
           +++    F+                   +   SG I      DRE+   Y+F V+A D G
Sbjct: 611 ILNDNDNFV-------------------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651

Query: 664 SPPMSSSTSVSITVLDVNDNDPVFTQP---TYELRLNEDAAVGSSVLTLQARDRDA--NS 718
            PP SS+  V+I V+DVNDN PV   P   T    +   A  GS V  + A D D   N+
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711

Query: 719 VITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLIN 778
            + Y +  GN +  F +    G   ITL           + L V  SD     + H L+ 
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN--ITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVL 769

Query: 779 V-----TDANTHRPVFQSSHYTVSVSEDRPVGTS 807
           V       A     ++     T+    DR +G S
Sbjct: 770 VFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDS 803



 Score =  171 bits (434), Expect = 8e-42
 Identities = 127/395 (32%), Positives = 190/395 (48%), Gaps = 36/395 (9%)

Query: 249 NYQVALFENEPAGT---LILQLHAHYTIEGE-----EERVSYYMEGLFDERSRGYFRIDS 300
           N  V L E +P  T   LI        + G+     E  V ++++ ++D +         
Sbjct: 368 NGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQY-------- 419

Query: 301 ATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE 360
               + T S+LD E  +    ++ A D   P  + T  + V ++D ND+ P+F Q     
Sbjct: 420 ---LLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476

Query: 361 RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEA 420
            V EN   G  + TI A+D DS  NA++ Y+ LG     F L+  +GV++   V DREE 
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQ-LGPNASFFDLDRKTGVLTASRVFDREEQ 535

Query: 421 AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480
             +   V A D G    PL + A V + V DENDN P+F+  ++   V E++   + V  
Sbjct: 536 ERFIFTVTARDNG--TPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593

Query: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG 540
           +  TD D G+N A+  SIL+ N    F L   SG++      D E    Y+  +KA DGG
Sbjct: 594 ITVTDADAGENKAVTLSILNDN--DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651

Query: 541 RPPLINSSGVVSVQVLDVNDNEPIFVSSP----FQATVLENVPLGYPVVHIQAVDADSGE 596
           +PP  +S+  V++ V+DVNDN P+ +S P    F+   L  +P G  V  + AVD D+G 
Sbjct: 652 QPPR-SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGM 709

Query: 597 NARLHYRLVDTASTFL------GGGSAGPKNPAPT 625
           NA L Y +V   +  L       G     + PAPT
Sbjct: 710 NAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPT 744



 Score =  122 bits (307), Expect = 4e-27
 Identities = 96/321 (29%), Positives = 149/321 (46%), Gaps = 13/321 (4%)

Query: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
           F  P  ++++ EN   G  +  + A     G+   + Y +       +  +F +D  TG 
Sbjct: 469 FNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP-----NASFFDLDRKTGV 523

Query: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
           ++   V DRE +E  +  V A D  TPP  +   + V V D ND+SP F  + ++  V E
Sbjct: 524 LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583

Query: 365 NLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQ 424
           NL     V  I  +D D+  N  +   +L    D F L+  SGV+ +    DRE+ + Y 
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDN-DNFVLDPYSGVIKSNVSFDREQQSSYT 642

Query: 425 LLVEANDQGRNPGPLSATATVYIEVEDENDNYPQF----SEQNYVVQVPEDVGLNTAVLR 480
             V+A D G+   P S+TA V I V D NDN P      S  ++ + VP      + V  
Sbjct: 643 FDVKATDGGQ--PPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL-VPLSAIPGSVVAE 699

Query: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG 540
           V A D D G NA + Y+I+SGN  G F +  ++G + +       DV  + L +   D G
Sbjct: 700 VFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLG 759

Query: 541 RPPLINSSGVVSVQVLDVNDN 561
            P  +++  +V + V D   N
Sbjct: 760 YPKSLHTLVLVFLYVNDTAGN 780


>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
          Length = 1340

 Score =  284 bits (727), Expect = 8e-76
 Identities = 218/680 (32%), Positives = 330/680 (48%), Gaps = 55/680 (8%)

Query: 557  DVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGS 616
            D+NDN P+F ++    ++ EN  +        AVD D G N   +Y L+ + + F     
Sbjct: 163  DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIF----- 217

Query: 617  AGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSIT 676
                +   TP+      +    + V  ELDREE + Y   V+  D G P  SS+  + ++
Sbjct: 218  --GLDVIETPE-----GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 270

Query: 677  VLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQ---LTGGNTRN 731
            V D NDN PVF +   E+ + E+A VG+SV  L A D D   N+ I +    L     R 
Sbjct: 271  VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330

Query: 732  RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG-TRSHTAHVLINVTDANTHRP--- 787
             F L++  G  LIT+  PLD ++   + L V ASDG      A VL+NVTD N + P   
Sbjct: 331  LFHLNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 388

Query: 788  ---VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTM 844
               +    + TV +SE+ P+ T IA ++  D+D   N R+T      +P FR+ P     
Sbjct: 389  IRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQ 447

Query: 845  YTMME---LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSI 901
            + +     LDYE+   Y + ++A D G P  + +  L I + D NDNAP F   F   SI
Sbjct: 448  FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 507

Query: 902  FEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
             E+  P   +++VSATD DSGPN  + Y    G D   +F ++  +G++   ++LDRE  
Sbjct: 508  PENNSPGIQLMKVSATDADSGPNAEINYLL--GPDAPPEFSLDRRTGMLTVVKKLDREKE 565

Query: 962  AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKI 1021
              Y    LA D G P PL+++V + V+I+D NDN+P+F  +E + +V EN P    V  I
Sbjct: 566  DKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLI 624

Query: 1022 RANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL 1081
               DPD G N+ +   I+  D    F +D   G +R  +  D E +  Y   V+A     
Sbjct: 625  TVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 682

Query: 1082 VSR---ATVHILLVDQNDNPPV--LPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPD--V 1134
            VSR   A V I +VD NDN PV  +P +     +Y     ++ P  V+  + A D D  +
Sbjct: 683  VSRSSSAKVTINVVDVNDNKPVFIVPPYNY---SYELVLPSTNPGTVVFQVIAVDNDTGM 739

Query: 1135 SDSLNYTFVQGNELRLLLLDPATGELQLSR-----DLDNNRPLEALMEVSVSDGIHSVTA 1189
            +  + Y+ V GN   L  +D  TG + L       DL  +R L    ++   D + SV  
Sbjct: 740  NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 799

Query: 1190 FCTLRVTIITDDMLTNSITV 1209
                 V +  ++ +TN+  +
Sbjct: 800  -----VNLFVNESVTNATLI 814



 Score =  280 bits (716), Expect = 2e-74
 Identities = 220/754 (29%), Positives = 355/754 (47%), Gaps = 59/754 (7%)

Query: 297  RIDSATGAV-STDSVLDRET------KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDH 349
            RI+  TG + +T + +DRE       ++ H      V            I  L++D ND+
Sbjct: 108  RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 167

Query: 350  SPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG----AWDVFQLNES 405
            +P+F  +     + EN  +  +     A D D  IN    Y ++        DV +  E 
Sbjct: 168  APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 227

Query: 406  SGV--VSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQN 463
              +  +  +  LDREE   Y + V+  D G      S+TA + + V D NDN+P F E  
Sbjct: 228  DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR--SSTAILQVSVTDTNDNHPVFKETE 285

Query: 464  YVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI--LSGNVAGQ-FYLHSLSGILDVIN 520
              V +PE+  + T+V ++ ATD D G+NA IH+S   L  N+A + F+L++ +G++ +  
Sbjct: 286  IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345

Query: 521  PLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI----FVSSPFQATVL- 575
            PLD E+   + L + A DGG  P   +  +V V V DVNDN P     ++ +P   TV+ 
Sbjct: 346  PLDREETPNHKLLVLASDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVL 402

Query: 576  -ENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHN 634
             EN+PL   +  I   D D+  N R+      T  T        P    P     F + N
Sbjct: 403  SENIPLNTKIALITVTDKDADHNGRV------TCFT----DHEIPFRLRPVFSNQFLLEN 452

Query: 635  SSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYEL 694
            +       A LD E  + Y+  + A D G PP++ S  + I V D NDN PVFTQ    +
Sbjct: 453  A-------AYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTV 505

Query: 695  RLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDY 752
             + E+ + G  ++ + A D D+  N+ I Y L G +    F+L   R  G++T+   LD 
Sbjct: 506  SIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLD--RRTGMLTVVKKLDR 562

Query: 753  KQEQQYVLAVTASD-GTRSHTAHV--LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIA 809
            ++E +Y+  + A D G    T++V   +++ D N + PVF  + Y   V E+ P   ++ 
Sbjct: 563  EKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVG 622

Query: 810  TLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGI 869
             ++  D D G+N+ +T  I D    F ID  +G +   +  D E Q +YT  + A+D G 
Sbjct: 623  LITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 682

Query: 870  PQKSDTTTLEILILDANDNAPQFLWDFYQGS---IFEDAPPSTSILQVSATDRDSGPNGR 926
              +S +  + I ++D NDN P F+   Y  S   +     P T + QV A D D+G N  
Sbjct: 683  VSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAE 742

Query: 927  LLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQ 986
            + Y+  GG+  D  F I+  +G I    + D  ++ ++ +   A D G P  L + V + 
Sbjct: 743  VRYSIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVN 801

Query: 987  VTILDINDNAPMFE---KDELELFVEENNPVGSV 1017
            + + +   NA +     +  +E  V  N  +  V
Sbjct: 802  LFVNESVTNATLINELVRKSIEAPVTPNTEIADV 835



 Score =  224 bits (572), Expect = 8e-58
 Identities = 171/538 (31%), Positives = 258/538 (47%), Gaps = 47/538 (8%)

Query: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
           F     +V++ EN P GT + QLHA     GE  ++ +    L    +R  F +++ TG 
Sbjct: 281 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 340

Query: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR- 363
           ++    LDRE    H L V A D    P  A   + V V D ND+ P  +       V  
Sbjct: 341 ITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVND 398

Query: 364 -----ENLEVGYEVLTIRASDRDSPINANLR----YRVLGGAWDVFQLNESSGVVSTRAV 414
                EN+ +  ++  I  +D+D+  N  +     + +      VF    +  ++   A 
Sbjct: 399 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLENAAY 455

Query: 415 LDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL 474
           LD E   EY + + A D G+   PL+ +A ++I+V+DENDN P F++    V +PE+   
Sbjct: 456 LDYESTKEYAIKLLAADAGK--PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 513

Query: 475 NTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSI 534
              +++V ATD D G NA I+Y +L  +   +F L   +G+L V+  LD E   KY  +I
Sbjct: 514 GIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTI 572

Query: 535 KAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADS 594
            A+D G PPL  S+  V V ++D NDN P+F  + ++  V EN+P    V  I   D D 
Sbjct: 573 LAKDNGVPPL-TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 631

Query: 595 GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
           G+N+ +   ++D                    +  F I + +G I      DRE+ E Y+
Sbjct: 632 GDNSAVTLSILD-------------------ENDDFTIDSQTGVIRPNISFDREKQESYT 672

Query: 655 FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQP----TYELRLNEDAAVGSSVLTLQ 710
           F V+A D G    SSS  V+I V+DVNDN PVF  P    +YEL L      G+ V  + 
Sbjct: 673 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVL-PSTNPGTVVFQVI 731

Query: 711 ARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
           A D D   N+ + Y + GGNTR+ FA+  + G   ITL    D      + + V A+D
Sbjct: 732 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGN--ITLMEKCDVTDLGLHRVLVKAND 787



 Score =  179 bits (454), Expect = 4e-44
 Identities = 137/438 (31%), Positives = 216/438 (49%), Gaps = 30/438 (6%)

Query: 249 NYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTD 308
           N  V L EN P  T I  +           RV+ + +     R R  F   S    +   
Sbjct: 397 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLENA 453

Query: 309 SVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEV 368
           + LD E+ + + +++ A D   PP + +  + + VKD ND++PVF QS     + EN   
Sbjct: 454 AYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 513

Query: 369 GYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVE 428
           G +++ + A+D DS  NA + Y +   A   F L+  +G+++    LDRE+  +Y   + 
Sbjct: 514 GIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTIL 573

Query: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
           A D G    PL++  TV++ + D+NDN P F+   Y   VPE++  +  V  +  TD D 
Sbjct: 574 AKDNG--VPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 631

Query: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
           G N+A+  SIL  N    F + S +G++      D E  + Y+  +KA+DGGR    +SS
Sbjct: 632 GDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR-SSS 688

Query: 549 GVVSVQVLDVNDNEPIFVSSPFQAT---VLENVPLGYPVVHIQAVDADSGENARLHYRLV 605
             V++ V+DVNDN+P+F+  P+  +   VL +   G  V  + AVD D+G NA + Y +V
Sbjct: 689 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 748

Query: 606 DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP 665
                   GG+        T D  F I   +G IT+  + D  ++  +   V+A D G P
Sbjct: 749 --------GGN--------TRDL-FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791

Query: 666 PMSSSTSVSITVLDVNDN 683
              S  SV I  L VN++
Sbjct: 792 --DSLFSVVIVNLFVNES 807



 Score =  103 bits (257), Expect = 3e-21
 Identities = 108/387 (27%), Positives = 170/387 (43%), Gaps = 34/387 (8%)

Query: 790  QSSHYTV--SVSEDRPVGTSIATLSAN-----DEDTGENARITYVIQDPVPQFRIDPDSG 842
            Q  +YT+   + E+  +G  +  L+ +        T    ++ Y   D VP  RI+ D+G
Sbjct: 56   QEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGD-VPLIRIEEDTG 114

Query: 843  TMYTM-MELDYENQVA---------YTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
             ++T    +D E   A         Y + +    + I +      +  LI D NDNAP F
Sbjct: 115  EIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFR---LVKIRFLIEDINDNAPLF 171

Query: 893  LWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG---- 948
                   SI E++  ++     +A D D G NG   Y      +  G   IE   G    
Sbjct: 172  PATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMP 231

Query: 949  VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFV 1008
             +  Q+ LDRE    Y +     D G P   S ++ +QV++ D NDN P+F++ E+E+ +
Sbjct: 232  QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTNDNHPVFKETEIEVSI 290

Query: 1009 EENNPVGSVVAKIRANDPDEGPNAQIMY---QIVEGDMRHFFQLDLLNGDLRAMVELDFE 1065
             EN PVG+ V ++ A D D G NA+I +    +V    R  F L+   G +     LD E
Sbjct: 291  PENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDRE 350

Query: 1066 VRREYVLVVQATSAPLV-SRATVHILLVDQNDNPPVLPDFQILFN--NYVTNKSNSFPTG 1122
                + L+V A+   L+ +RA V + + D NDN P + D + + N  N     S + P  
Sbjct: 351  ETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSI-DIRYIVNPVNDTVVLSENIPLN 409

Query: 1123 V-IGCIPAHDPDVSDSLNYTFVQGNEL 1148
              I  I   D D   +   T    +E+
Sbjct: 410  TKIALITVTDKDADHNGRVTCFTDHEI 436


>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
          Length = 1048

 Score =  284 bits (727), Expect = 8e-76
 Identities = 218/680 (32%), Positives = 330/680 (48%), Gaps = 55/680 (8%)

Query: 557  DVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGS 616
            D+NDN P+F ++    ++ EN  +        AVD D G N   +Y L+ + + F     
Sbjct: 163  DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIF----- 217

Query: 617  AGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSIT 676
                +   TP+      +    + V  ELDREE + Y   V+  D G P  SS+  + ++
Sbjct: 218  --GLDVIETPE-----GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 270

Query: 677  VLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQ---LTGGNTRN 731
            V D NDN PVF +   E+ + E+A VG+SV  L A D D   N+ I +    L     R 
Sbjct: 271  VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330

Query: 732  RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG-TRSHTAHVLINVTDANTHRP--- 787
             F L++  G  LIT+  PLD ++   + L V ASDG      A VL+NVTD N + P   
Sbjct: 331  LFHLNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 388

Query: 788  ---VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTM 844
               +    + TV +SE+ P+ T IA ++  D+D   N R+T      +P FR+ P     
Sbjct: 389  IRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQ 447

Query: 845  YTMME---LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSI 901
            + +     LDYE+   Y + ++A D G P  + +  L I + D NDNAP F   F   SI
Sbjct: 448  FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 507

Query: 902  FEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
             E+  P   +++VSATD DSGPN  + Y    G D   +F ++  +G++   ++LDRE  
Sbjct: 508  PENNSPGIQLMKVSATDADSGPNAEINYLL--GPDAPPEFSLDRRTGMLTVVKKLDREKE 565

Query: 962  AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKI 1021
              Y    LA D G P PL+++V + V+I+D NDN+P+F  +E + +V EN P    V  I
Sbjct: 566  DKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLI 624

Query: 1022 RANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL 1081
               DPD G N+ +   I+  D    F +D   G +R  +  D E +  Y   V+A     
Sbjct: 625  TVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 682

Query: 1082 VSR---ATVHILLVDQNDNPPV--LPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPD--V 1134
            VSR   A V I +VD NDN PV  +P +     +Y     ++ P  V+  + A D D  +
Sbjct: 683  VSRSSSAKVTINVVDVNDNKPVFIVPPYNY---SYELVLPSTNPGTVVFQVIAVDNDTGM 739

Query: 1135 SDSLNYTFVQGNELRLLLLDPATGELQLSR-----DLDNNRPLEALMEVSVSDGIHSVTA 1189
            +  + Y+ V GN   L  +D  TG + L       DL  +R L    ++   D + SV  
Sbjct: 740  NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 799

Query: 1190 FCTLRVTIITDDMLTNSITV 1209
                 V +  ++ +TN+  +
Sbjct: 800  -----VNLFVNESVTNATLI 814



 Score =  280 bits (716), Expect = 2e-74
 Identities = 220/754 (29%), Positives = 355/754 (47%), Gaps = 59/754 (7%)

Query: 297  RIDSATGAV-STDSVLDRET------KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDH 349
            RI+  TG + +T + +DRE       ++ H      V            I  L++D ND+
Sbjct: 108  RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 167

Query: 350  SPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG----AWDVFQLNES 405
            +P+F  +     + EN  +  +     A D D  IN    Y ++        DV +  E 
Sbjct: 168  APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 227

Query: 406  SGV--VSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQN 463
              +  +  +  LDREE   Y + V+  D G      S+TA + + V D NDN+P F E  
Sbjct: 228  DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR--SSTAILQVSVTDTNDNHPVFKETE 285

Query: 464  YVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI--LSGNVAGQ-FYLHSLSGILDVIN 520
              V +PE+  + T+V ++ ATD D G+NA IH+S   L  N+A + F+L++ +G++ +  
Sbjct: 286  IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 345

Query: 521  PLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI----FVSSPFQATVL- 575
            PLD E+   + L + A DGG  P   +  +V V V DVNDN P     ++ +P   TV+ 
Sbjct: 346  PLDREETPNHKLLVLASDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVL 402

Query: 576  -ENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHN 634
             EN+PL   +  I   D D+  N R+      T  T        P    P     F + N
Sbjct: 403  SENIPLNTKIALITVTDKDADHNGRV------TCFT----DHEIPFRLRPVFSNQFLLEN 452

Query: 635  SSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYEL 694
            +       A LD E  + Y+  + A D G PP++ S  + I V D NDN PVFTQ    +
Sbjct: 453  A-------AYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTV 505

Query: 695  RLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDY 752
             + E+ + G  ++ + A D D+  N+ I Y L G +    F+L   R  G++T+   LD 
Sbjct: 506  SIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLD--RRTGMLTVVKKLDR 562

Query: 753  KQEQQYVLAVTASD-GTRSHTAHV--LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIA 809
            ++E +Y+  + A D G    T++V   +++ D N + PVF  + Y   V E+ P   ++ 
Sbjct: 563  EKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVG 622

Query: 810  TLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGI 869
             ++  D D G+N+ +T  I D    F ID  +G +   +  D E Q +YT  + A+D G 
Sbjct: 623  LITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 682

Query: 870  PQKSDTTTLEILILDANDNAPQFLWDFYQGS---IFEDAPPSTSILQVSATDRDSGPNGR 926
              +S +  + I ++D NDN P F+   Y  S   +     P T + QV A D D+G N  
Sbjct: 683  VSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAE 742

Query: 927  LLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQ 986
            + Y+  GG+  D  F I+  +G I    + D  ++ ++ +   A D G P  L + V + 
Sbjct: 743  VRYSIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVN 801

Query: 987  VTILDINDNAPMFE---KDELELFVEENNPVGSV 1017
            + + +   NA +     +  +E  V  N  +  V
Sbjct: 802  LFVNESVTNATLINELVRKSIEAPVTPNTEIADV 835



 Score =  224 bits (572), Expect = 8e-58
 Identities = 171/538 (31%), Positives = 258/538 (47%), Gaps = 47/538 (8%)

Query: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
           F     +V++ EN P GT + QLHA     GE  ++ +    L    +R  F +++ TG 
Sbjct: 281 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 340

Query: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR- 363
           ++    LDRE    H L V A D    P  A   + V V D ND+ P  +       V  
Sbjct: 341 ITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVND 398

Query: 364 -----ENLEVGYEVLTIRASDRDSPINANLR----YRVLGGAWDVFQLNESSGVVSTRAV 414
                EN+ +  ++  I  +D+D+  N  +     + +      VF    +  ++   A 
Sbjct: 399 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLENAAY 455

Query: 415 LDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL 474
           LD E   EY + + A D G+   PL+ +A ++I+V+DENDN P F++    V +PE+   
Sbjct: 456 LDYESTKEYAIKLLAADAGK--PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 513

Query: 475 NTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSI 534
              +++V ATD D G NA I+Y +L  +   +F L   +G+L V+  LD E   KY  +I
Sbjct: 514 GIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTI 572

Query: 535 KAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADS 594
            A+D G PPL  S+  V V ++D NDN P+F  + ++  V EN+P    V  I   D D 
Sbjct: 573 LAKDNGVPPL-TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 631

Query: 595 GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
           G+N+ +   ++D                    +  F I + +G I      DRE+ E Y+
Sbjct: 632 GDNSAVTLSILD-------------------ENDDFTIDSQTGVIRPNISFDREKQESYT 672

Query: 655 FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQP----TYELRLNEDAAVGSSVLTLQ 710
           F V+A D G    SSS  V+I V+DVNDN PVF  P    +YEL L      G+ V  + 
Sbjct: 673 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVL-PSTNPGTVVFQVI 731

Query: 711 ARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
           A D D   N+ + Y + GGNTR+ FA+  + G   ITL    D      + + V A+D
Sbjct: 732 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGN--ITLMEKCDVTDLGLHRVLVKAND 787



 Score =  179 bits (454), Expect = 4e-44
 Identities = 137/438 (31%), Positives = 216/438 (49%), Gaps = 30/438 (6%)

Query: 249 NYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTD 308
           N  V L EN P  T I  +           RV+ + +     R R  F   S    +   
Sbjct: 397 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLENA 453

Query: 309 SVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEV 368
           + LD E+ + + +++ A D   PP + +  + + VKD ND++PVF QS     + EN   
Sbjct: 454 AYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 513

Query: 369 GYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVE 428
           G +++ + A+D DS  NA + Y +   A   F L+  +G+++    LDRE+  +Y   + 
Sbjct: 514 GIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTIL 573

Query: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
           A D G    PL++  TV++ + D+NDN P F+   Y   VPE++  +  V  +  TD D 
Sbjct: 574 AKDNG--VPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 631

Query: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
           G N+A+  SIL  N    F + S +G++      D E  + Y+  +KA+DGGR    +SS
Sbjct: 632 GDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR-SSS 688

Query: 549 GVVSVQVLDVNDNEPIFVSSPFQAT---VLENVPLGYPVVHIQAVDADSGENARLHYRLV 605
             V++ V+DVNDN+P+F+  P+  +   VL +   G  V  + AVD D+G NA + Y +V
Sbjct: 689 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 748

Query: 606 DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP 665
                   GG+        T D  F I   +G IT+  + D  ++  +   V+A D G P
Sbjct: 749 --------GGN--------TRDL-FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 791

Query: 666 PMSSSTSVSITVLDVNDN 683
              S  SV I  L VN++
Sbjct: 792 --DSLFSVVIVNLFVNES 807



 Score =  103 bits (257), Expect = 3e-21
 Identities = 108/387 (27%), Positives = 170/387 (43%), Gaps = 34/387 (8%)

Query: 790  QSSHYTV--SVSEDRPVGTSIATLSAN-----DEDTGENARITYVIQDPVPQFRIDPDSG 842
            Q  +YT+   + E+  +G  +  L+ +        T    ++ Y   D VP  RI+ D+G
Sbjct: 56   QEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGD-VPLIRIEEDTG 114

Query: 843  TMYTM-MELDYENQVA---------YTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
             ++T    +D E   A         Y + +    + I +      +  LI D NDNAP F
Sbjct: 115  EIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFR---LVKIRFLIEDINDNAPLF 171

Query: 893  LWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG---- 948
                   SI E++  ++     +A D D G NG   Y      +  G   IE   G    
Sbjct: 172  PATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMP 231

Query: 949  VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFV 1008
             +  Q+ LDRE    Y +     D G P   S ++ +QV++ D NDN P+F++ E+E+ +
Sbjct: 232  QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTNDNHPVFKETEIEVSI 290

Query: 1009 EENNPVGSVVAKIRANDPDEGPNAQIMY---QIVEGDMRHFFQLDLLNGDLRAMVELDFE 1065
             EN PVG+ V ++ A D D G NA+I +    +V    R  F L+   G +     LD E
Sbjct: 291  PENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDRE 350

Query: 1066 VRREYVLVVQATSAPLV-SRATVHILLVDQNDNPPVLPDFQILFN--NYVTNKSNSFPTG 1122
                + L+V A+   L+ +RA V + + D NDN P + D + + N  N     S + P  
Sbjct: 351  ETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSI-DIRYIVNPVNDTVVLSENIPLN 409

Query: 1123 V-IGCIPAHDPDVSDSLNYTFVQGNEL 1148
              I  I   D D   +   T    +E+
Sbjct: 410  TKIALITVTDKDADHNGRVTCFTDHEI 436


>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
          Length = 1037

 Score =  284 bits (727), Expect = 8e-76
 Identities = 218/680 (32%), Positives = 330/680 (48%), Gaps = 55/680 (8%)

Query: 557  DVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGS 616
            D+NDN P+F ++    ++ EN  +        AVD D G N   +Y L+ + + F     
Sbjct: 152  DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIF----- 206

Query: 617  AGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSIT 676
                +   TP+      +    + V  ELDREE + Y   V+  D G P  SS+  + ++
Sbjct: 207  --GLDVIETPE-----GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 259

Query: 677  VLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQ---LTGGNTRN 731
            V D NDN PVF +   E+ + E+A VG+SV  L A D D   N+ I +    L     R 
Sbjct: 260  VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 319

Query: 732  RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG-TRSHTAHVLINVTDANTHRP--- 787
             F L++  G  LIT+  PLD ++   + L V ASDG      A VL+NVTD N + P   
Sbjct: 320  LFHLNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 377

Query: 788  ---VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTM 844
               +    + TV +SE+ P+ T IA ++  D+D   N R+T      +P FR+ P     
Sbjct: 378  IRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQ 436

Query: 845  YTMME---LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSI 901
            + +     LDYE+   Y + ++A D G P  + +  L I + D NDNAP F   F   SI
Sbjct: 437  FLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 496

Query: 902  FEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
             E+  P   +++VSATD DSGPN  + Y    G D   +F ++  +G++   ++LDRE  
Sbjct: 497  PENNSPGIQLMKVSATDADSGPNAEINYLL--GPDAPPEFSLDRRTGMLTVVKKLDREKE 554

Query: 962  AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKI 1021
              Y    LA D G P PL+++V + V+I+D NDN+P+F  +E + +V EN P    V  I
Sbjct: 555  DKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLI 613

Query: 1022 RANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL 1081
               DPD G N+ +   I+  D    F +D   G +R  +  D E +  Y   V+A     
Sbjct: 614  TVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 671

Query: 1082 VSR---ATVHILLVDQNDNPPV--LPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPD--V 1134
            VSR   A V I +VD NDN PV  +P +     +Y     ++ P  V+  + A D D  +
Sbjct: 672  VSRSSSAKVTINVVDVNDNKPVFIVPPYNY---SYELVLPSTNPGTVVFQVIAVDNDTGM 728

Query: 1135 SDSLNYTFVQGNELRLLLLDPATGELQLSR-----DLDNNRPLEALMEVSVSDGIHSVTA 1189
            +  + Y+ V GN   L  +D  TG + L       DL  +R L    ++   D + SV  
Sbjct: 729  NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 788

Query: 1190 FCTLRVTIITDDMLTNSITV 1209
                 V +  ++ +TN+  +
Sbjct: 789  -----VNLFVNESVTNATLI 803



 Score =  280 bits (716), Expect = 2e-74
 Identities = 220/754 (29%), Positives = 355/754 (47%), Gaps = 59/754 (7%)

Query: 297  RIDSATGAV-STDSVLDRET------KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDH 349
            RI+  TG + +T + +DRE       ++ H      V            I  L++D ND+
Sbjct: 97   RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 156

Query: 350  SPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG----AWDVFQLNES 405
            +P+F  +     + EN  +  +     A D D  IN    Y ++        DV +  E 
Sbjct: 157  APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 216

Query: 406  SGV--VSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQN 463
              +  +  +  LDREE   Y + V+  D G      S+TA + + V D NDN+P F E  
Sbjct: 217  DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR--SSTAILQVSVTDTNDNHPVFKETE 274

Query: 464  YVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI--LSGNVAGQ-FYLHSLSGILDVIN 520
              V +PE+  + T+V ++ ATD D G+NA IH+S   L  N+A + F+L++ +G++ +  
Sbjct: 275  IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 334

Query: 521  PLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI----FVSSPFQATVL- 575
            PLD E+   + L + A DGG  P   +  +V V V DVNDN P     ++ +P   TV+ 
Sbjct: 335  PLDREETPNHKLLVLASDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVL 391

Query: 576  -ENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHN 634
             EN+PL   +  I   D D+  N R+      T  T        P    P     F + N
Sbjct: 392  SENIPLNTKIALITVTDKDADHNGRV------TCFT----DHEIPFRLRPVFSNQFLLEN 441

Query: 635  SSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYEL 694
            +       A LD E  + Y+  + A D G PP++ S  + I V D NDN PVFTQ    +
Sbjct: 442  A-------AYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTV 494

Query: 695  RLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDY 752
             + E+ + G  ++ + A D D+  N+ I Y L G +    F+L   R  G++T+   LD 
Sbjct: 495  SIPENNSPGIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLD--RRTGMLTVVKKLDR 551

Query: 753  KQEQQYVLAVTASD-GTRSHTAHV--LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIA 809
            ++E +Y+  + A D G    T++V   +++ D N + PVF  + Y   V E+ P   ++ 
Sbjct: 552  EKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVG 611

Query: 810  TLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGI 869
             ++  D D G+N+ +T  I D    F ID  +G +   +  D E Q +YT  + A+D G 
Sbjct: 612  LITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 671

Query: 870  PQKSDTTTLEILILDANDNAPQFLWDFYQGS---IFEDAPPSTSILQVSATDRDSGPNGR 926
              +S +  + I ++D NDN P F+   Y  S   +     P T + QV A D D+G N  
Sbjct: 672  VSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAE 731

Query: 927  LLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQ 986
            + Y+  GG+  D  F I+  +G I    + D  ++ ++ +   A D G P  L + V + 
Sbjct: 732  VRYSIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVN 790

Query: 987  VTILDINDNAPMFE---KDELELFVEENNPVGSV 1017
            + + +   NA +     +  +E  V  N  +  V
Sbjct: 791  LFVNESVTNATLINELVRKSIEAPVTPNTEIADV 824



 Score =  224 bits (572), Expect = 8e-58
 Identities = 171/538 (31%), Positives = 258/538 (47%), Gaps = 47/538 (8%)

Query: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
           F     +V++ EN P GT + QLHA     GE  ++ +    L    +R  F +++ TG 
Sbjct: 270 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 329

Query: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR- 363
           ++    LDRE    H L V A D    P  A   + V V D ND+ P  +       V  
Sbjct: 330 ITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVND 387

Query: 364 -----ENLEVGYEVLTIRASDRDSPINANLR----YRVLGGAWDVFQLNESSGVVSTRAV 414
                EN+ +  ++  I  +D+D+  N  +     + +      VF    +  ++   A 
Sbjct: 388 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLENAAY 444

Query: 415 LDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL 474
           LD E   EY + + A D G+   PL+ +A ++I+V+DENDN P F++    V +PE+   
Sbjct: 445 LDYESTKEYAIKLLAADAGK--PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 502

Query: 475 NTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSI 534
              +++V ATD D G NA I+Y +L  +   +F L   +G+L V+  LD E   KY  +I
Sbjct: 503 GIQLMKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTI 561

Query: 535 KAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADS 594
            A+D G PPL  S+  V V ++D NDN P+F  + ++  V EN+P    V  I   D D 
Sbjct: 562 LAKDNGVPPL-TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 620

Query: 595 GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
           G+N+ +   ++D                    +  F I + +G I      DRE+ E Y+
Sbjct: 621 GDNSAVTLSILD-------------------ENDDFTIDSQTGVIRPNISFDREKQESYT 661

Query: 655 FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQP----TYELRLNEDAAVGSSVLTLQ 710
           F V+A D G    SSS  V+I V+DVNDN PVF  P    +YEL L      G+ V  + 
Sbjct: 662 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVL-PSTNPGTVVFQVI 720

Query: 711 ARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
           A D D   N+ + Y + GGNTR+ FA+  + G   ITL    D      + + V A+D
Sbjct: 721 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGN--ITLMEKCDVTDLGLHRVLVKAND 776



 Score =  179 bits (454), Expect = 4e-44
 Identities = 137/438 (31%), Positives = 216/438 (49%), Gaps = 30/438 (6%)

Query: 249 NYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTD 308
           N  V L EN P  T I  +           RV+ + +     R R  F   S    +   
Sbjct: 386 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLENA 442

Query: 309 SVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEV 368
           + LD E+ + + +++ A D   PP + +  + + VKD ND++PVF QS     + EN   
Sbjct: 443 AYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 502

Query: 369 GYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVE 428
           G +++ + A+D DS  NA + Y +   A   F L+  +G+++    LDRE+  +Y   + 
Sbjct: 503 GIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTIL 562

Query: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
           A D G    PL++  TV++ + D+NDN P F+   Y   VPE++  +  V  +  TD D 
Sbjct: 563 AKDNG--VPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 620

Query: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
           G N+A+  SIL  N    F + S +G++      D E  + Y+  +KA+DGGR    +SS
Sbjct: 621 GDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR-SSS 677

Query: 549 GVVSVQVLDVNDNEPIFVSSPFQAT---VLENVPLGYPVVHIQAVDADSGENARLHYRLV 605
             V++ V+DVNDN+P+F+  P+  +   VL +   G  V  + AVD D+G NA + Y +V
Sbjct: 678 AKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 737

Query: 606 DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP 665
                   GG+        T D  F I   +G IT+  + D  ++  +   V+A D G P
Sbjct: 738 --------GGN--------TRDL-FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 780

Query: 666 PMSSSTSVSITVLDVNDN 683
              S  SV I  L VN++
Sbjct: 781 --DSLFSVVIVNLFVNES 796



 Score =  103 bits (257), Expect = 3e-21
 Identities = 108/387 (27%), Positives = 170/387 (43%), Gaps = 34/387 (8%)

Query: 790  QSSHYTV--SVSEDRPVGTSIATLSAN-----DEDTGENARITYVIQDPVPQFRIDPDSG 842
            Q  +YT+   + E+  +G  +  L+ +        T    ++ Y   D VP  RI+ D+G
Sbjct: 45   QEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGD-VPLIRIEEDTG 103

Query: 843  TMYTM-MELDYENQVA---------YTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
             ++T    +D E   A         Y + +    + I +      +  LI D NDNAP F
Sbjct: 104  EIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFR---LVKIRFLIEDINDNAPLF 160

Query: 893  LWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG---- 948
                   SI E++  ++     +A D D G NG   Y      +  G   IE   G    
Sbjct: 161  PATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMP 220

Query: 949  VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFV 1008
             +  Q+ LDRE    Y +     D G P   S ++ +QV++ D NDN P+F++ E+E+ +
Sbjct: 221  QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI-LQVSVTDTNDNHPVFKETEIEVSI 279

Query: 1009 EENNPVGSVVAKIRANDPDEGPNAQIMY---QIVEGDMRHFFQLDLLNGDLRAMVELDFE 1065
             EN PVG+ V ++ A D D G NA+I +    +V    R  F L+   G +     LD E
Sbjct: 280  PENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDRE 339

Query: 1066 VRREYVLVVQATSAPLV-SRATVHILLVDQNDNPPVLPDFQILFN--NYVTNKSNSFPTG 1122
                + L+V A+   L+ +RA V + + D NDN P + D + + N  N     S + P  
Sbjct: 340  ETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSI-DIRYIVNPVNDTVVLSENIPLN 398

Query: 1123 V-IGCIPAHDPDVSDSLNYTFVQGNEL 1148
              I  I   D D   +   T    +E+
Sbjct: 399  TKIALITVTDKDADHNGRVTCFTDHEI 425


>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
            sapiens]
          Length = 1021

 Score =  281 bits (718), Expect = 9e-75
 Identities = 229/714 (32%), Positives = 341/714 (47%), Gaps = 61/714 (8%)

Query: 557  DVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGS 616
            D+NDN P+F ++    ++ EN  +        AVD D G N   +Y L+ + + F     
Sbjct: 131  DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIF----- 185

Query: 617  AGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSIT 676
                +   TP+      +    + V  ELDREE + Y   V+  D G P  SS+  + ++
Sbjct: 186  --GLDVIETPE-----GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238

Query: 677  VLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQ---LTGGNTRN 731
            V D NDN PVF +   E+ + E+A VG+SV  L A D D   N+ I +    L     R 
Sbjct: 239  VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298

Query: 732  RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG-TRSHTAHVLINVTDANTHRP--- 787
             F L++  G  LIT+  PLD ++   + L V ASDG      A VL+NVTD N + P   
Sbjct: 299  LFHLNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 356

Query: 788  ---VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTM 844
               +    + TV +SE+ P+ T IA ++  D+D   N R+T      +P FR+ P     
Sbjct: 357  IRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQ 415

Query: 845  Y---TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSI 901
            +   T   LDYE+   Y + ++A D G P  + +  L I + D NDNAP F   F   SI
Sbjct: 416  FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 475

Query: 902  FEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
             E+  P   + +VSA D DSGPN ++ Y    G D   +F ++  +G++   ++LDRE  
Sbjct: 476  PENNSPGIQLTKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKE 533

Query: 962  AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKI 1021
              Y    LA D G P PL+++V + V+I+D NDN+P+F  +E   +V EN P    V  I
Sbjct: 534  DKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLI 592

Query: 1022 RANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL 1081
               DPD G N+ +   I+  D    F +D   G +R  +  D E +  Y   V+A     
Sbjct: 593  TVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 650

Query: 1082 VSR---ATVHILLVDQNDNPPVLPDFQILFNN--YVTNKSNSFPTGVIGCIPAHDPD--V 1134
            VSR   A V I +VD NDN PV   F +  +N  Y     ++ P  V+  + A D D  +
Sbjct: 651  VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707

Query: 1135 SDSLNYTFVQGNELRLLLLDPATGELQLSR-----DLDNNRPLEALMEVSVSDGIHSVTA 1189
            +  + Y+ V GN   L  +D  TG + L       DL  +R L    ++   D + SV  
Sbjct: 708  NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767

Query: 1190 FCTLRVTIITDDMLTNSITV-RLENMSQEKFLSPLLALFVEGVAAVLSTTKDDV 1242
                 V +  ++ +TN+  +  L   S E  ++P        +A V S T D V
Sbjct: 768  -----VNLFVNESVTNATLINELVRKSTEAPVTPNTE-----IADVSSPTSDYV 811



 Score =  275 bits (703), Expect = 5e-73
 Identities = 212/738 (28%), Positives = 349/738 (47%), Gaps = 62/738 (8%)

Query: 297  RIDSATGAV-STDSVLDRET------KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDH 349
            RI+  TG + +T + +DRE       ++ H      V            I  L++D ND+
Sbjct: 76   RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 135

Query: 350  SPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG----AWDVFQLNES 405
            +P+F  +     + EN  +  +     A D D  IN    Y ++        DV +  E 
Sbjct: 136  APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195

Query: 406  SGV--VSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQN 463
              +  +  +  LDREE   Y + V+  D G      S+TA + + V D NDN+P F E  
Sbjct: 196  DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR--SSTAILQVSVTDTNDNHPVFKETE 253

Query: 464  YVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI--LSGNVAGQ-FYLHSLSGILDVIN 520
              V +PE+  + T+V ++ ATD D G+NA IH+S   L  N+A + F+L++ +G++ +  
Sbjct: 254  IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313

Query: 521  PLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI----FVSSPFQATVL- 575
            PLD E+   + L + A DGG  P   +  +V V V DVNDN P     ++ +P   TV+ 
Sbjct: 314  PLDREETPNHKLLVLASDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVL 370

Query: 576  -ENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIH- 633
             EN+PL   +  I   D D+  N R+      T  T                + PF++  
Sbjct: 371  SENIPLNTKIALITVTDKDADHNGRV------TCFT--------------DHEIPFRLRP 410

Query: 634  --NSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPT 691
              ++   +   A LD E  + Y+  + A D G PP++ S  + I V D NDN PVFTQ  
Sbjct: 411  VFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF 470

Query: 692  YELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALP 749
              + + E+ + G  +  + A D D+  N+ I Y L G +    F+L  + G  ++T+   
Sbjct: 471  VTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTG--MLTVVKK 527

Query: 750  LDYKQEQQYVLAVTASD-GTRSHTAHV--LINVTDANTHRPVFQSSHYTVSVSEDRPVGT 806
            LD ++E +Y+  + A D G    T++V   +++ D N + PVF  + Y   V E+ P   
Sbjct: 528  LDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHG 587

Query: 807  SIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQD 866
            ++  ++  D D G+N+ +T  I D    F ID  +G +   +  D E Q +YT  + A+D
Sbjct: 588  TVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAED 647

Query: 867  NGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS---IFEDAPPSTSILQVSATDRDSGP 923
             G   +S +  + I ++D NDN P F+      S   +     P T + QV A D D+G 
Sbjct: 648  GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707

Query: 924  NGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASV 983
            N  + Y+  GG+  D  F I+  +G I    + D  ++ ++ +   A D G P  L + V
Sbjct: 708  NAEVRYSIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVV 766

Query: 984  EIQVTILDINDNAPMFEK 1001
             + + + +   NA +  +
Sbjct: 767  IVNLFVNESVTNATLINE 784



 Score =  223 bits (567), Expect = 3e-57
 Identities = 171/538 (31%), Positives = 256/538 (47%), Gaps = 47/538 (8%)

Query: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
           F     +V++ EN P GT + QLHA     GE  ++ +    L    +R  F +++ TG 
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308

Query: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR- 363
           ++    LDRE    H L V A D    P  A   + V V D ND+ P  +       V  
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366

Query: 364 -----ENLEVGYEVLTIRASDRDSPINANLR----YRVLGGAWDVFQLNESSGVVSTRAV 414
                EN+ +  ++  I  +D+D+  N  +     + +      VF    +  ++ T A 
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLETAAY 423

Query: 415 LDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL 474
           LD E   EY + + A D G+   PL+ +A ++I+V+DENDN P F++    V +PE+   
Sbjct: 424 LDYESTKEYAIKLLAADAGK--PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 481

Query: 475 NTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSI 534
              + +V A D D G NA I+Y +L  +   +F L   +G+L V+  LD E   KY  +I
Sbjct: 482 GIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTI 540

Query: 535 KAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADS 594
            A+D G PPL  S+  V V ++D NDN P+F  + +   V EN+P    V  I   D D 
Sbjct: 541 LAKDNGVPPL-TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 595 GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
           G+N+ +   ++D                    +  F I + +G I      DRE+ E Y+
Sbjct: 600 GDNSAVTLSILD-------------------ENDDFTIDSQTGVIRPNISFDREKQESYT 640

Query: 655 FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQP----TYELRLNEDAAVGSSVLTLQ 710
           F V+A D G    SSS  V+I V+DVNDN PVF  P    +YEL L      G+ V  + 
Sbjct: 641 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL-PSTNPGTVVFQVI 699

Query: 711 ARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
           A D D   N+ + Y + GGNTR+ FA+  + G   ITL    D      + + V A+D
Sbjct: 700 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGN--ITLMEKCDVTDLGLHRVLVKAND 755



 Score =  176 bits (446), Expect = 3e-43
 Identities = 138/438 (31%), Positives = 214/438 (48%), Gaps = 30/438 (6%)

Query: 249 NYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTD 308
           N  V L EN P  T I  +           RV+ + +     R R  F   S    + T 
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLETA 421

Query: 309 SVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEV 368
           + LD E+ + + +++ A D   PP + +  + + VKD ND++PVF QS     + EN   
Sbjct: 422 AYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 481

Query: 369 GYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVE 428
           G ++  + A D DS  NA + Y +   A   F L+  +G+++    LDRE+  +Y   + 
Sbjct: 482 GIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTIL 541

Query: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
           A D G    PL++  TV++ + D+NDN P F+   Y   VPE++  +  V  +  TD D 
Sbjct: 542 AKDNG--VPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
           G N+A+  SIL  N    F + S +G++      D E  + Y+  +KA+DGGR    +SS
Sbjct: 600 GDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR-SSS 656

Query: 549 GVVSVQVLDVNDNEPIFVSSPFQAT---VLENVPLGYPVVHIQAVDADSGENARLHYRLV 605
             V++ V+DVNDN+P+F+  P   +   VL +   G  V  + AVD D+G NA + Y +V
Sbjct: 657 AKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 716

Query: 606 DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP 665
                   GG+        T D  F I   +G IT+  + D  ++  +   V+A D G P
Sbjct: 717 --------GGN--------TRDL-FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759

Query: 666 PMSSSTSVSITVLDVNDN 683
              S  SV I  L VN++
Sbjct: 760 --DSLFSVVIVNLFVNES 775



 Score =  103 bits (257), Expect = 3e-21
 Identities = 102/352 (28%), Positives = 156/352 (44%), Gaps = 27/352 (7%)

Query: 818  TGENARITYVIQDPVPQFRIDPDSGTMYTM-MELDYENQVA---------YTLTIMAQDN 867
            T    ++ Y   D VP  RI+ D+G ++T    +D E   A         Y + +    +
Sbjct: 59   TAMQFKLVYKTGD-VPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD 117

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRL 927
             I +      +  LI D NDNAP F       SI E++  ++     +A D D G NG  
Sbjct: 118  EIFR---LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQ 174

Query: 928  LYTFQGGDDGDGDFYIEPTSG----VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASV 983
             Y      +  G   IE   G     +  Q+ LDRE    Y +     D G P   S ++
Sbjct: 175  NYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234

Query: 984  EIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMY---QIVE 1040
             +QV++ D NDN P+F++ E+E+ + EN PVG+ V ++ A D D G NA+I +    +V 
Sbjct: 235  -LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293

Query: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV-SRATVHILLVDQNDNPP 1099
               R  F L+   G +     LD E    + L+V A+   L+ +RA V + + D NDN P
Sbjct: 294  NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 353

Query: 1100 VLPDFQILFN--NYVTNKSNSFPTGV-IGCIPAHDPDVSDSLNYTFVQGNEL 1148
             + D + + N  N     S + P    I  I   D D   +   T    +E+
Sbjct: 354  SI-DIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI 404


>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
          Length = 1337

 Score =  281 bits (718), Expect = 9e-75
 Identities = 229/714 (32%), Positives = 341/714 (47%), Gaps = 61/714 (8%)

Query: 557  DVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGS 616
            D+NDN P+F ++    ++ EN  +        AVD D G N   +Y L+ + + F     
Sbjct: 131  DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIF----- 185

Query: 617  AGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSIT 676
                +   TP+      +    + V  ELDREE + Y   V+  D G P  SS+  + ++
Sbjct: 186  --GLDVIETPE-----GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238

Query: 677  VLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQ---LTGGNTRN 731
            V D NDN PVF +   E+ + E+A VG+SV  L A D D   N+ I +    L     R 
Sbjct: 239  VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298

Query: 732  RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG-TRSHTAHVLINVTDANTHRP--- 787
             F L++  G  LIT+  PLD ++   + L V ASDG      A VL+NVTD N + P   
Sbjct: 299  LFHLNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 356

Query: 788  ---VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTM 844
               +    + TV +SE+ P+ T IA ++  D+D   N R+T      +P FR+ P     
Sbjct: 357  IRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQ 415

Query: 845  Y---TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSI 901
            +   T   LDYE+   Y + ++A D G P  + +  L I + D NDNAP F   F   SI
Sbjct: 416  FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 475

Query: 902  FEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
             E+  P   + +VSA D DSGPN ++ Y    G D   +F ++  +G++   ++LDRE  
Sbjct: 476  PENNSPGIQLTKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKE 533

Query: 962  AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKI 1021
              Y    LA D G P PL+++V + V+I+D NDN+P+F  +E   +V EN P    V  I
Sbjct: 534  DKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLI 592

Query: 1022 RANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL 1081
               DPD G N+ +   I+  D    F +D   G +R  +  D E +  Y   V+A     
Sbjct: 593  TVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 650

Query: 1082 VSR---ATVHILLVDQNDNPPVLPDFQILFNN--YVTNKSNSFPTGVIGCIPAHDPD--V 1134
            VSR   A V I +VD NDN PV   F +  +N  Y     ++ P  V+  + A D D  +
Sbjct: 651  VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707

Query: 1135 SDSLNYTFVQGNELRLLLLDPATGELQLSR-----DLDNNRPLEALMEVSVSDGIHSVTA 1189
            +  + Y+ V GN   L  +D  TG + L       DL  +R L    ++   D + SV  
Sbjct: 708  NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767

Query: 1190 FCTLRVTIITDDMLTNSITV-RLENMSQEKFLSPLLALFVEGVAAVLSTTKDDV 1242
                 V +  ++ +TN+  +  L   S E  ++P        +A V S T D V
Sbjct: 768  -----VNLFVNESVTNATLINELVRKSTEAPVTPNTE-----IADVSSPTSDYV 811



 Score =  275 bits (703), Expect = 5e-73
 Identities = 212/738 (28%), Positives = 349/738 (47%), Gaps = 62/738 (8%)

Query: 297  RIDSATGAV-STDSVLDRET------KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDH 349
            RI+  TG + +T + +DRE       ++ H      V            I  L++D ND+
Sbjct: 76   RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 135

Query: 350  SPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG----AWDVFQLNES 405
            +P+F  +     + EN  +  +     A D D  IN    Y ++        DV +  E 
Sbjct: 136  APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195

Query: 406  SGV--VSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQN 463
              +  +  +  LDREE   Y + V+  D G      S+TA + + V D NDN+P F E  
Sbjct: 196  DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR--SSTAILQVSVTDTNDNHPVFKETE 253

Query: 464  YVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI--LSGNVAGQ-FYLHSLSGILDVIN 520
              V +PE+  + T+V ++ ATD D G+NA IH+S   L  N+A + F+L++ +G++ +  
Sbjct: 254  IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313

Query: 521  PLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI----FVSSPFQATVL- 575
            PLD E+   + L + A DGG  P   +  +V V V DVNDN P     ++ +P   TV+ 
Sbjct: 314  PLDREETPNHKLLVLASDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVL 370

Query: 576  -ENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIH- 633
             EN+PL   +  I   D D+  N R+      T  T                + PF++  
Sbjct: 371  SENIPLNTKIALITVTDKDADHNGRV------TCFT--------------DHEIPFRLRP 410

Query: 634  --NSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPT 691
              ++   +   A LD E  + Y+  + A D G PP++ S  + I V D NDN PVFTQ  
Sbjct: 411  VFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF 470

Query: 692  YELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALP 749
              + + E+ + G  +  + A D D+  N+ I Y L G +    F+L  + G  ++T+   
Sbjct: 471  VTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTG--MLTVVKK 527

Query: 750  LDYKQEQQYVLAVTASD-GTRSHTAHV--LINVTDANTHRPVFQSSHYTVSVSEDRPVGT 806
            LD ++E +Y+  + A D G    T++V   +++ D N + PVF  + Y   V E+ P   
Sbjct: 528  LDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHG 587

Query: 807  SIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQD 866
            ++  ++  D D G+N+ +T  I D    F ID  +G +   +  D E Q +YT  + A+D
Sbjct: 588  TVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAED 647

Query: 867  NGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS---IFEDAPPSTSILQVSATDRDSGP 923
             G   +S +  + I ++D NDN P F+      S   +     P T + QV A D D+G 
Sbjct: 648  GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707

Query: 924  NGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASV 983
            N  + Y+  GG+  D  F I+  +G I    + D  ++ ++ +   A D G P  L + V
Sbjct: 708  NAEVRYSIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVV 766

Query: 984  EIQVTILDINDNAPMFEK 1001
             + + + +   NA +  +
Sbjct: 767  IVNLFVNESVTNATLINE 784



 Score =  223 bits (567), Expect = 3e-57
 Identities = 171/538 (31%), Positives = 256/538 (47%), Gaps = 47/538 (8%)

Query: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
           F     +V++ EN P GT + QLHA     GE  ++ +    L    +R  F +++ TG 
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308

Query: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR- 363
           ++    LDRE    H L V A D    P  A   + V V D ND+ P  +       V  
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366

Query: 364 -----ENLEVGYEVLTIRASDRDSPINANLR----YRVLGGAWDVFQLNESSGVVSTRAV 414
                EN+ +  ++  I  +D+D+  N  +     + +      VF    +  ++ T A 
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLETAAY 423

Query: 415 LDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL 474
           LD E   EY + + A D G+   PL+ +A ++I+V+DENDN P F++    V +PE+   
Sbjct: 424 LDYESTKEYAIKLLAADAGK--PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 481

Query: 475 NTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSI 534
              + +V A D D G NA I+Y +L  +   +F L   +G+L V+  LD E   KY  +I
Sbjct: 482 GIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTI 540

Query: 535 KAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADS 594
            A+D G PPL  S+  V V ++D NDN P+F  + +   V EN+P    V  I   D D 
Sbjct: 541 LAKDNGVPPL-TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 595 GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
           G+N+ +   ++D                    +  F I + +G I      DRE+ E Y+
Sbjct: 600 GDNSAVTLSILD-------------------ENDDFTIDSQTGVIRPNISFDREKQESYT 640

Query: 655 FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQP----TYELRLNEDAAVGSSVLTLQ 710
           F V+A D G    SSS  V+I V+DVNDN PVF  P    +YEL L      G+ V  + 
Sbjct: 641 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL-PSTNPGTVVFQVI 699

Query: 711 ARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
           A D D   N+ + Y + GGNTR+ FA+  + G   ITL    D      + + V A+D
Sbjct: 700 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGN--ITLMEKCDVTDLGLHRVLVKAND 755



 Score =  176 bits (446), Expect = 3e-43
 Identities = 138/438 (31%), Positives = 214/438 (48%), Gaps = 30/438 (6%)

Query: 249 NYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTD 308
           N  V L EN P  T I  +           RV+ + +     R R  F   S    + T 
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLETA 421

Query: 309 SVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEV 368
           + LD E+ + + +++ A D   PP + +  + + VKD ND++PVF QS     + EN   
Sbjct: 422 AYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 481

Query: 369 GYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVE 428
           G ++  + A D DS  NA + Y +   A   F L+  +G+++    LDRE+  +Y   + 
Sbjct: 482 GIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTIL 541

Query: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
           A D G    PL++  TV++ + D+NDN P F+   Y   VPE++  +  V  +  TD D 
Sbjct: 542 AKDNG--VPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
           G N+A+  SIL  N    F + S +G++      D E  + Y+  +KA+DGGR    +SS
Sbjct: 600 GDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR-SSS 656

Query: 549 GVVSVQVLDVNDNEPIFVSSPFQAT---VLENVPLGYPVVHIQAVDADSGENARLHYRLV 605
             V++ V+DVNDN+P+F+  P   +   VL +   G  V  + AVD D+G NA + Y +V
Sbjct: 657 AKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 716

Query: 606 DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP 665
                   GG+        T D  F I   +G IT+  + D  ++  +   V+A D G P
Sbjct: 717 --------GGN--------TRDL-FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759

Query: 666 PMSSSTSVSITVLDVNDN 683
              S  SV I  L VN++
Sbjct: 760 --DSLFSVVIVNLFVNES 775



 Score =  103 bits (257), Expect = 3e-21
 Identities = 102/352 (28%), Positives = 156/352 (44%), Gaps = 27/352 (7%)

Query: 818  TGENARITYVIQDPVPQFRIDPDSGTMYTM-MELDYENQVA---------YTLTIMAQDN 867
            T    ++ Y   D VP  RI+ D+G ++T    +D E   A         Y + +    +
Sbjct: 59   TAMQFKLVYKTGD-VPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD 117

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRL 927
             I +      +  LI D NDNAP F       SI E++  ++     +A D D G NG  
Sbjct: 118  EIFR---LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQ 174

Query: 928  LYTFQGGDDGDGDFYIEPTSG----VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASV 983
             Y      +  G   IE   G     +  Q+ LDRE    Y +     D G P   S ++
Sbjct: 175  NYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234

Query: 984  EIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMY---QIVE 1040
             +QV++ D NDN P+F++ E+E+ + EN PVG+ V ++ A D D G NA+I +    +V 
Sbjct: 235  -LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293

Query: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV-SRATVHILLVDQNDNPP 1099
               R  F L+   G +     LD E    + L+V A+   L+ +RA V + + D NDN P
Sbjct: 294  NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 353

Query: 1100 VLPDFQILFN--NYVTNKSNSFPTGV-IGCIPAHDPDVSDSLNYTFVQGNEL 1148
             + D + + N  N     S + P    I  I   D D   +   T    +E+
Sbjct: 354  SI-DIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI 404


>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
          Length = 1347

 Score =  281 bits (718), Expect = 9e-75
 Identities = 229/714 (32%), Positives = 341/714 (47%), Gaps = 61/714 (8%)

Query: 557  DVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGS 616
            D+NDN P+F ++    ++ EN  +        AVD D G N   +Y L+ + + F     
Sbjct: 131  DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIF----- 185

Query: 617  AGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSIT 676
                +   TP+      +    + V  ELDREE + Y   V+  D G P  SS+  + ++
Sbjct: 186  --GLDVIETPE-----GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238

Query: 677  VLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQ---LTGGNTRN 731
            V D NDN PVF +   E+ + E+A VG+SV  L A D D   N+ I +    L     R 
Sbjct: 239  VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298

Query: 732  RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG-TRSHTAHVLINVTDANTHRP--- 787
             F L++  G  LIT+  PLD ++   + L V ASDG      A VL+NVTD N + P   
Sbjct: 299  LFHLNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 356

Query: 788  ---VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTM 844
               +    + TV +SE+ P+ T IA ++  D+D   N R+T      +P FR+ P     
Sbjct: 357  IRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQ 415

Query: 845  Y---TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSI 901
            +   T   LDYE+   Y + ++A D G P  + +  L I + D NDNAP F   F   SI
Sbjct: 416  FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 475

Query: 902  FEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
             E+  P   + +VSA D DSGPN ++ Y    G D   +F ++  +G++   ++LDRE  
Sbjct: 476  PENNSPGIQLTKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKE 533

Query: 962  AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKI 1021
              Y    LA D G P PL+++V + V+I+D NDN+P+F  +E   +V EN P    V  I
Sbjct: 534  DKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLI 592

Query: 1022 RANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL 1081
               DPD G N+ +   I+  D    F +D   G +R  +  D E +  Y   V+A     
Sbjct: 593  TVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 650

Query: 1082 VSR---ATVHILLVDQNDNPPVLPDFQILFNN--YVTNKSNSFPTGVIGCIPAHDPD--V 1134
            VSR   A V I +VD NDN PV   F +  +N  Y     ++ P  V+  + A D D  +
Sbjct: 651  VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707

Query: 1135 SDSLNYTFVQGNELRLLLLDPATGELQLSR-----DLDNNRPLEALMEVSVSDGIHSVTA 1189
            +  + Y+ V GN   L  +D  TG + L       DL  +R L    ++   D + SV  
Sbjct: 708  NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767

Query: 1190 FCTLRVTIITDDMLTNSITV-RLENMSQEKFLSPLLALFVEGVAAVLSTTKDDV 1242
                 V +  ++ +TN+  +  L   S E  ++P        +A V S T D V
Sbjct: 768  -----VNLFVNESVTNATLINELVRKSTEAPVTPNTE-----IADVSSPTSDYV 811



 Score =  275 bits (703), Expect = 5e-73
 Identities = 212/738 (28%), Positives = 349/738 (47%), Gaps = 62/738 (8%)

Query: 297  RIDSATGAV-STDSVLDRET------KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDH 349
            RI+  TG + +T + +DRE       ++ H      V            I  L++D ND+
Sbjct: 76   RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 135

Query: 350  SPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG----AWDVFQLNES 405
            +P+F  +     + EN  +  +     A D D  IN    Y ++        DV +  E 
Sbjct: 136  APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195

Query: 406  SGV--VSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQN 463
              +  +  +  LDREE   Y + V+  D G      S+TA + + V D NDN+P F E  
Sbjct: 196  DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR--SSTAILQVSVTDTNDNHPVFKETE 253

Query: 464  YVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI--LSGNVAGQ-FYLHSLSGILDVIN 520
              V +PE+  + T+V ++ ATD D G+NA IH+S   L  N+A + F+L++ +G++ +  
Sbjct: 254  IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313

Query: 521  PLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI----FVSSPFQATVL- 575
            PLD E+   + L + A DGG  P   +  +V V V DVNDN P     ++ +P   TV+ 
Sbjct: 314  PLDREETPNHKLLVLASDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVL 370

Query: 576  -ENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIH- 633
             EN+PL   +  I   D D+  N R+      T  T                + PF++  
Sbjct: 371  SENIPLNTKIALITVTDKDADHNGRV------TCFT--------------DHEIPFRLRP 410

Query: 634  --NSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPT 691
              ++   +   A LD E  + Y+  + A D G PP++ S  + I V D NDN PVFTQ  
Sbjct: 411  VFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF 470

Query: 692  YELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALP 749
              + + E+ + G  +  + A D D+  N+ I Y L G +    F+L  + G  ++T+   
Sbjct: 471  VTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTG--MLTVVKK 527

Query: 750  LDYKQEQQYVLAVTASD-GTRSHTAHV--LINVTDANTHRPVFQSSHYTVSVSEDRPVGT 806
            LD ++E +Y+  + A D G    T++V   +++ D N + PVF  + Y   V E+ P   
Sbjct: 528  LDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHG 587

Query: 807  SIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQD 866
            ++  ++  D D G+N+ +T  I D    F ID  +G +   +  D E Q +YT  + A+D
Sbjct: 588  TVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAED 647

Query: 867  NGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS---IFEDAPPSTSILQVSATDRDSGP 923
             G   +S +  + I ++D NDN P F+      S   +     P T + QV A D D+G 
Sbjct: 648  GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707

Query: 924  NGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASV 983
            N  + Y+  GG+  D  F I+  +G I    + D  ++ ++ +   A D G P  L + V
Sbjct: 708  NAEVRYSIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVV 766

Query: 984  EIQVTILDINDNAPMFEK 1001
             + + + +   NA +  +
Sbjct: 767  IVNLFVNESVTNATLINE 784



 Score =  223 bits (567), Expect = 3e-57
 Identities = 171/538 (31%), Positives = 256/538 (47%), Gaps = 47/538 (8%)

Query: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
           F     +V++ EN P GT + QLHA     GE  ++ +    L    +R  F +++ TG 
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308

Query: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR- 363
           ++    LDRE    H L V A D    P  A   + V V D ND+ P  +       V  
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366

Query: 364 -----ENLEVGYEVLTIRASDRDSPINANLR----YRVLGGAWDVFQLNESSGVVSTRAV 414
                EN+ +  ++  I  +D+D+  N  +     + +      VF    +  ++ T A 
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLETAAY 423

Query: 415 LDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL 474
           LD E   EY + + A D G+   PL+ +A ++I+V+DENDN P F++    V +PE+   
Sbjct: 424 LDYESTKEYAIKLLAADAGK--PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 481

Query: 475 NTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSI 534
              + +V A D D G NA I+Y +L  +   +F L   +G+L V+  LD E   KY  +I
Sbjct: 482 GIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTI 540

Query: 535 KAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADS 594
            A+D G PPL  S+  V V ++D NDN P+F  + +   V EN+P    V  I   D D 
Sbjct: 541 LAKDNGVPPL-TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 595 GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
           G+N+ +   ++D                    +  F I + +G I      DRE+ E Y+
Sbjct: 600 GDNSAVTLSILD-------------------ENDDFTIDSQTGVIRPNISFDREKQESYT 640

Query: 655 FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQP----TYELRLNEDAAVGSSVLTLQ 710
           F V+A D G    SSS  V+I V+DVNDN PVF  P    +YEL L      G+ V  + 
Sbjct: 641 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL-PSTNPGTVVFQVI 699

Query: 711 ARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
           A D D   N+ + Y + GGNTR+ FA+  + G   ITL    D      + + V A+D
Sbjct: 700 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGN--ITLMEKCDVTDLGLHRVLVKAND 755



 Score =  176 bits (446), Expect = 3e-43
 Identities = 138/438 (31%), Positives = 214/438 (48%), Gaps = 30/438 (6%)

Query: 249 NYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTD 308
           N  V L EN P  T I  +           RV+ + +     R R  F   S    + T 
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLETA 421

Query: 309 SVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEV 368
           + LD E+ + + +++ A D   PP + +  + + VKD ND++PVF QS     + EN   
Sbjct: 422 AYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 481

Query: 369 GYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVE 428
           G ++  + A D DS  NA + Y +   A   F L+  +G+++    LDRE+  +Y   + 
Sbjct: 482 GIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTIL 541

Query: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
           A D G    PL++  TV++ + D+NDN P F+   Y   VPE++  +  V  +  TD D 
Sbjct: 542 AKDNG--VPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
           G N+A+  SIL  N    F + S +G++      D E  + Y+  +KA+DGGR    +SS
Sbjct: 600 GDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR-SSS 656

Query: 549 GVVSVQVLDVNDNEPIFVSSPFQAT---VLENVPLGYPVVHIQAVDADSGENARLHYRLV 605
             V++ V+DVNDN+P+F+  P   +   VL +   G  V  + AVD D+G NA + Y +V
Sbjct: 657 AKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 716

Query: 606 DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP 665
                   GG+        T D  F I   +G IT+  + D  ++  +   V+A D G P
Sbjct: 717 --------GGN--------TRDL-FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759

Query: 666 PMSSSTSVSITVLDVNDN 683
              S  SV I  L VN++
Sbjct: 760 --DSLFSVVIVNLFVNES 775



 Score =  103 bits (257), Expect = 3e-21
 Identities = 102/352 (28%), Positives = 156/352 (44%), Gaps = 27/352 (7%)

Query: 818  TGENARITYVIQDPVPQFRIDPDSGTMYTM-MELDYENQVA---------YTLTIMAQDN 867
            T    ++ Y   D VP  RI+ D+G ++T    +D E   A         Y + +    +
Sbjct: 59   TAMQFKLVYKTGD-VPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD 117

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRL 927
             I +      +  LI D NDNAP F       SI E++  ++     +A D D G NG  
Sbjct: 118  EIFR---LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQ 174

Query: 928  LYTFQGGDDGDGDFYIEPTSG----VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASV 983
             Y      +  G   IE   G     +  Q+ LDRE    Y +     D G P   S ++
Sbjct: 175  NYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234

Query: 984  EIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMY---QIVE 1040
             +QV++ D NDN P+F++ E+E+ + EN PVG+ V ++ A D D G NA+I +    +V 
Sbjct: 235  -LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293

Query: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV-SRATVHILLVDQNDNPP 1099
               R  F L+   G +     LD E    + L+V A+   L+ +RA V + + D NDN P
Sbjct: 294  NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 353

Query: 1100 VLPDFQILFN--NYVTNKSNSFPTGV-IGCIPAHDPDVSDSLNYTFVQGNEL 1148
             + D + + N  N     S + P    I  I   D D   +   T    +E+
Sbjct: 354  SI-DIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI 404


>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
            sapiens]
          Length = 1025

 Score =  281 bits (718), Expect = 9e-75
 Identities = 229/714 (32%), Positives = 341/714 (47%), Gaps = 61/714 (8%)

Query: 557  DVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGS 616
            D+NDN P+F ++    ++ EN  +        AVD D G N   +Y L+ + + F     
Sbjct: 131  DINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIF----- 185

Query: 617  AGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSIT 676
                +   TP+      +    + V  ELDREE + Y   V+  D G P  SS+  + ++
Sbjct: 186  --GLDVIETPE-----GDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238

Query: 677  VLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQ---LTGGNTRN 731
            V D NDN PVF +   E+ + E+A VG+SV  L A D D   N+ I +    L     R 
Sbjct: 239  VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298

Query: 732  RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG-TRSHTAHVLINVTDANTHRP--- 787
             F L++  G  LIT+  PLD ++   + L V ASDG      A VL+NVTD N + P   
Sbjct: 299  LFHLNATTG--LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 356

Query: 788  ---VFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTM 844
               +    + TV +SE+ P+ T IA ++  D+D   N R+T      +P FR+ P     
Sbjct: 357  IRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIP-FRLRPVFSNQ 415

Query: 845  Y---TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSI 901
            +   T   LDYE+   Y + ++A D G P  + +  L I + D NDNAP F   F   SI
Sbjct: 416  FLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSI 475

Query: 902  FEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
             E+  P   + +VSA D DSGPN ++ Y    G D   +F ++  +G++   ++LDRE  
Sbjct: 476  PENNSPGIQLTKVSAMDADSGPNAKINYLL--GPDAPPEFSLDCRTGMLTVVKKLDREKE 533

Query: 962  AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKI 1021
              Y    LA D G P PL+++V + V+I+D NDN+P+F  +E   +V EN P    V  I
Sbjct: 534  DKYLFTILAKDNGVP-PLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLI 592

Query: 1022 RANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL 1081
               DPD G N+ +   I+  D    F +D   G +R  +  D E +  Y   V+A     
Sbjct: 593  TVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGR 650

Query: 1082 VSR---ATVHILLVDQNDNPPVLPDFQILFNN--YVTNKSNSFPTGVIGCIPAHDPD--V 1134
            VSR   A V I +VD NDN PV   F +  +N  Y     ++ P  V+  + A D D  +
Sbjct: 651  VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707

Query: 1135 SDSLNYTFVQGNELRLLLLDPATGELQLSR-----DLDNNRPLEALMEVSVSDGIHSVTA 1189
            +  + Y+ V GN   L  +D  TG + L       DL  +R L    ++   D + SV  
Sbjct: 708  NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767

Query: 1190 FCTLRVTIITDDMLTNSITV-RLENMSQEKFLSPLLALFVEGVAAVLSTTKDDV 1242
                 V +  ++ +TN+  +  L   S E  ++P        +A V S T D V
Sbjct: 768  -----VNLFVNESVTNATLINELVRKSTEAPVTPNTE-----IADVSSPTSDYV 811



 Score =  275 bits (703), Expect = 5e-73
 Identities = 212/738 (28%), Positives = 349/738 (47%), Gaps = 62/738 (8%)

Query: 297  RIDSATGAV-STDSVLDRET------KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDH 349
            RI+  TG + +T + +DRE       ++ H      V            I  L++D ND+
Sbjct: 76   RIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDN 135

Query: 350  SPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG----AWDVFQLNES 405
            +P+F  +     + EN  +  +     A D D  IN    Y ++        DV +  E 
Sbjct: 136  APLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEG 195

Query: 406  SGV--VSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQN 463
              +  +  +  LDREE   Y + V+  D G      S+TA + + V D NDN+P F E  
Sbjct: 196  DKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR--SSTAILQVSVTDTNDNHPVFKETE 253

Query: 464  YVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI--LSGNVAGQ-FYLHSLSGILDVIN 520
              V +PE+  + T+V ++ ATD D G+NA IH+S   L  N+A + F+L++ +G++ +  
Sbjct: 254  IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKE 313

Query: 521  PLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPI----FVSSPFQATVL- 575
            PLD E+   + L + A DGG  P   +  +V V V DVNDN P     ++ +P   TV+ 
Sbjct: 314  PLDREETPNHKLLVLASDGGLMP---ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVL 370

Query: 576  -ENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIH- 633
             EN+PL   +  I   D D+  N R+      T  T                + PF++  
Sbjct: 371  SENIPLNTKIALITVTDKDADHNGRV------TCFT--------------DHEIPFRLRP 410

Query: 634  --NSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPT 691
              ++   +   A LD E  + Y+  + A D G PP++ S  + I V D NDN PVFTQ  
Sbjct: 411  VFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF 470

Query: 692  YELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALP 749
              + + E+ + G  +  + A D D+  N+ I Y L G +    F+L  + G  ++T+   
Sbjct: 471  VTVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTG--MLTVVKK 527

Query: 750  LDYKQEQQYVLAVTASD-GTRSHTAHV--LINVTDANTHRPVFQSSHYTVSVSEDRPVGT 806
            LD ++E +Y+  + A D G    T++V   +++ D N + PVF  + Y   V E+ P   
Sbjct: 528  LDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHG 587

Query: 807  SIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQD 866
            ++  ++  D D G+N+ +T  I D    F ID  +G +   +  D E Q +YT  + A+D
Sbjct: 588  TVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAED 647

Query: 867  NGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS---IFEDAPPSTSILQVSATDRDSGP 923
             G   +S +  + I ++D NDN P F+      S   +     P T + QV A D D+G 
Sbjct: 648  GGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707

Query: 924  NGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASV 983
            N  + Y+  GG+  D  F I+  +G I    + D  ++ ++ +   A D G P  L + V
Sbjct: 708  NAEVRYSIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVV 766

Query: 984  EIQVTILDINDNAPMFEK 1001
             + + + +   NA +  +
Sbjct: 767  IVNLFVNESVTNATLINE 784



 Score =  223 bits (567), Expect = 3e-57
 Identities = 171/538 (31%), Positives = 256/538 (47%), Gaps = 47/538 (8%)

Query: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
           F     +V++ EN P GT + QLHA     GE  ++ +    L    +R  F +++ TG 
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGL 308

Query: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVR- 363
           ++    LDRE    H L V A D    P  A   + V V D ND+ P  +       V  
Sbjct: 309 ITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366

Query: 364 -----ENLEVGYEVLTIRASDRDSPINANLR----YRVLGGAWDVFQLNESSGVVSTRAV 414
                EN+ +  ++  I  +D+D+  N  +     + +      VF    +  ++ T A 
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLETAAY 423

Query: 415 LDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL 474
           LD E   EY + + A D G+   PL+ +A ++I+V+DENDN P F++    V +PE+   
Sbjct: 424 LDYESTKEYAIKLLAADAGK--PPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 481

Query: 475 NTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSI 534
              + +V A D D G NA I+Y +L  +   +F L   +G+L V+  LD E   KY  +I
Sbjct: 482 GIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTI 540

Query: 535 KAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADS 594
            A+D G PPL  S+  V V ++D NDN P+F  + +   V EN+P    V  I   D D 
Sbjct: 541 LAKDNGVPPL-TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 595 GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
           G+N+ +   ++D                    +  F I + +G I      DRE+ E Y+
Sbjct: 600 GDNSAVTLSILD-------------------ENDDFTIDSQTGVIRPNISFDREKQESYT 640

Query: 655 FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQP----TYELRLNEDAAVGSSVLTLQ 710
           F V+A D G    SSS  V+I V+DVNDN PVF  P    +YEL L      G+ V  + 
Sbjct: 641 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVL-PSTNPGTVVFQVI 699

Query: 711 ARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
           A D D   N+ + Y + GGNTR+ FA+  + G   ITL    D      + + V A+D
Sbjct: 700 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGN--ITLMEKCDVTDLGLHRVLVKAND 755



 Score =  176 bits (446), Expect = 3e-43
 Identities = 138/438 (31%), Positives = 214/438 (48%), Gaps = 30/438 (6%)

Query: 249 NYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTD 308
           N  V L EN P  T I  +           RV+ + +     R R  F   S    + T 
Sbjct: 365 NDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVF---SNQFLLETA 421

Query: 309 SVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEV 368
           + LD E+ + + +++ A D   PP + +  + + VKD ND++PVF QS     + EN   
Sbjct: 422 AYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSP 481

Query: 369 GYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVE 428
           G ++  + A D DS  NA + Y +   A   F L+  +G+++    LDRE+  +Y   + 
Sbjct: 482 GIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTIL 541

Query: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
           A D G    PL++  TV++ + D+NDN P F+   Y   VPE++  +  V  +  TD D 
Sbjct: 542 AKDNG--VPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDY 599

Query: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
           G N+A+  SIL  N    F + S +G++      D E  + Y+  +KA+DGGR    +SS
Sbjct: 600 GDNSAVTLSILDEN--DDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR-SSS 656

Query: 549 GVVSVQVLDVNDNEPIFVSSPFQAT---VLENVPLGYPVVHIQAVDADSGENARLHYRLV 605
             V++ V+DVNDN+P+F+  P   +   VL +   G  V  + AVD D+G NA + Y +V
Sbjct: 657 AKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIV 716

Query: 606 DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP 665
                   GG+        T D  F I   +G IT+  + D  ++  +   V+A D G P
Sbjct: 717 --------GGN--------TRDL-FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 759

Query: 666 PMSSSTSVSITVLDVNDN 683
              S  SV I  L VN++
Sbjct: 760 --DSLFSVVIVNLFVNES 775



 Score =  103 bits (257), Expect = 3e-21
 Identities = 102/352 (28%), Positives = 156/352 (44%), Gaps = 27/352 (7%)

Query: 818  TGENARITYVIQDPVPQFRIDPDSGTMYTM-MELDYENQVA---------YTLTIMAQDN 867
            T    ++ Y   D VP  RI+ D+G ++T    +D E   A         Y + +    +
Sbjct: 59   TAMQFKLVYKTGD-VPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPD 117

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRL 927
             I +      +  LI D NDNAP F       SI E++  ++     +A D D G NG  
Sbjct: 118  EIFR---LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQ 174

Query: 928  LYTFQGGDDGDGDFYIEPTSG----VIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASV 983
             Y      +  G   IE   G     +  Q+ LDRE    Y +     D G P   S ++
Sbjct: 175  NYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234

Query: 984  EIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMY---QIVE 1040
             +QV++ D NDN P+F++ E+E+ + EN PVG+ V ++ A D D G NA+I +    +V 
Sbjct: 235  -LQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVS 293

Query: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV-SRATVHILLVDQNDNPP 1099
               R  F L+   G +     LD E    + L+V A+   L+ +RA V + + D NDN P
Sbjct: 294  NIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVP 353

Query: 1100 VLPDFQILFN--NYVTNKSNSFPTGV-IGCIPAHDPDVSDSLNYTFVQGNEL 1148
             + D + + N  N     S + P    I  I   D D   +   T    +E+
Sbjct: 354  SI-DIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI 404


>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
          Length = 1955

 Score =  268 bits (685), Expect = 6e-71
 Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)

Query: 245  FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
            F MP+YQ  + E+ P G  I   L L +   I   ++ +    +         Y  + + 
Sbjct: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454

Query: 302  TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
            T    T  +     +DRE ++T+   + A D      S    + + V D ND++P F + 
Sbjct: 455  TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 512

Query: 357  EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
             Y   V  ++  G  V+ + A D D   N  + Y +L GA   F +N+++G+++    ++
Sbjct: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 572

Query: 417  REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475
                  Y L V+A D        ++  TVYIEV    N + P+F +  Y +++ E + + 
Sbjct: 573  MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 632

Query: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
              +L +QATDR+     +I Y+I +G+    F L   +GIL +   LD E   +Y L I 
Sbjct: 633  AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 689

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594
            A DG   P   S+  V++ V DVNDN P+F    P   +V+E     + V  ++A D D+
Sbjct: 690  ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 746

Query: 595  GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
            G N ++HY L +  + F                       S+G I    +L+RE  ++Y 
Sbjct: 747  GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 786

Query: 655  FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
              V A D    P  S+ +++I VLD++DN PVFT  TY + + E+   G+++L ++A+D 
Sbjct: 787  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846

Query: 715  DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768
            D  + ++Y++     ++ FAL    G   ++L   LDY+    QE      V A D  GT
Sbjct: 847  DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 904

Query: 769  R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825
                 A V + V D N + PVF    Y   V+ D   GT I T+ A D D      +R+ 
Sbjct: 905  MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964

Query: 826  YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
            Y + D     P   F ++ DSG + T + L+ E    + L ++A D+G P  S + T++I
Sbjct: 965  YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024

Query: 881  LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
            L+L   +  P+F  + Y+   + E A   T +  +SA    +  N  ++Y+   G++ D 
Sbjct: 1025 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1078

Query: 940  DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992
             F I   +GVI     LD E    Y       +L  +  +   P+  S + ++ + I D 
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1137

Query: 993  NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047
            N++ P+F+K      V E+  + + V +++A D D G  + + Y+++     EG  +  F
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1195

Query: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
             ++   G ++  + L   +RR Y    V+        L  +A V + +V+Q D
Sbjct: 1196 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247



 Score =  265 bits (677), Expect = 5e-70
 Identities = 244/864 (28%), Positives = 392/864 (45%), Gaps = 105/864 (12%)

Query: 306  STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
            ST  VLDR+        V  V           Y  + ++V+D ND+SP F+   Y   V 
Sbjct: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157

Query: 364  ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412
            E   VG  + T       A+D D   N  + Y +        + D F++    +G +  R
Sbjct: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217

Query: 413  AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465
              L+ E+   Y ++++AND+ +N     + T T+ ++V D +D  P F     V      
Sbjct: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277

Query: 466  -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506
                       ++ PE++        +QA D+D+          I YSIL G        
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337

Query: 507  FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
            F++H  +  L ++ P++ +  QK+ L IKA+     PL   +G + +++LD N+  P F 
Sbjct: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 396

Query: 567  SSPFQATVLENVPLGYPV---------VHIQAVDAD--SGENARLHYRLVDTASTFLGGG 615
               +Q  +LE+ P+G  +         + I A+D D    ++  LH  L D  S F    
Sbjct: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 616  SAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSI 675
            +                   + ++T+   +DREE + Y+F + A D      S    V+I
Sbjct: 457  T-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNI 497

Query: 676  TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733
             V+D NDN P F + +Y++ +  D   G SV+ L A D D  +N  ITY++  G  +  F
Sbjct: 498  QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDF 556

Query: 734  ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV 788
             ++  +  GLIT+A  ++    + Y L V A+D       R+    V I V   N   P 
Sbjct: 557  IIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614

Query: 789  -FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMY 845
             F    Y++ +SE   VG  +  L A D    E   ITY I++  PQ  F +   +G + 
Sbjct: 615  RFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILT 671

Query: 846  TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905
                LD E+   Y L I A D G P  + T T+ I++ D NDNAP F     +     + 
Sbjct: 672  LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730

Query: 906  PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYN 965
              +  + QV ATD D+G NG++ Y+         + +   ++G I T  +L+RE    Y 
Sbjct: 731  EANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYE 786

Query: 966  LWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRAND 1025
            L  +A D G+  P  +++ + + +LDI+DN+P+F      + VEEN P G+ + +I A D
Sbjct: 787  LVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845

Query: 1026 PDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA----- 1076
             D G N  + Y+I   +++HFF L    G+L  +  LD+E           +V+A     
Sbjct: 846  VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903

Query: 1077 TSAPLVSRATVHILLVDQNDNPPV 1100
            T  P +  ATV +++ D ND PPV
Sbjct: 904  TMPPGI--ATVTVIVKDMNDYPPV 925



 Score =  252 bits (644), Expect = 3e-66
 Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
            +F +   T  +S    ++R+  +   L +KA   +  P  A   + + + D N+ SP F 
Sbjct: 337  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396

Query: 355  QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
               Y+  + E+  VG  +         L I A D+D     +    + L     VF + +
Sbjct: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 405  SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
             +G+     +L   DREE   Y   + A D  +   P+     V I+V D NDN P F E
Sbjct: 457  -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 511

Query: 462  QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
             +Y V V  D+    +V+++ A D D+G N  I Y IL G   G F ++  +G++ +   
Sbjct: 512  ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 570

Query: 522  LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579
            ++    + Y+L+++A D   P    NS   V ++VL  N+ + P F    +   + E + 
Sbjct: 571  VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630

Query: 580  LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
            +G  ++++QA D +            D+ +  +  G          P   F +  ++G +
Sbjct: 631  VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 670

Query: 640  TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698
            T+   LDRE  + Y   + A D G P  +S+ +V+I V DVNDN PVF  P     L+  
Sbjct: 671  TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 728

Query: 699  DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756
            +    + V  ++A D DA  N  + Y L  GN  N F ++S    G I  A+ L+ +   
Sbjct: 729  EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 783

Query: 757  QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
             Y L V A+DG    R  T  + I V D + + PVF +S YTV V E+ P GT+I  + A
Sbjct: 784  YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843

Query: 814  NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867
             D D G N  ++Y I+ P  +  F + P +G +  +  LDYE     + + T  + A D 
Sbjct: 844  KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925
                     T+ +++ D ND  P F    Y+G +  DA   T I  V A D D    P  
Sbjct: 902  YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961

Query: 926  RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980
            R+ Y     DD         F +E  SG + T+  L+ E   ++ L  +A D G P  +S
Sbjct: 962  RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 1017

Query: 981  ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
            +S  +++ +L   +  P F ++E     V E    G++V  I A       N  I+Y IV
Sbjct: 1018 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1072

Query: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089
             G+    F ++ + G +     LD+E R  YVL VQA S  +V          + A V+I
Sbjct: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132

Query: 1090 LLVDQNDNPPV 1100
             + D+N++PPV
Sbjct: 1133 EIQDENNHPPV 1143



 Score =  226 bits (575), Expect = 3e-58
 Identities = 239/862 (27%), Positives = 379/862 (43%), Gaps = 109/862 (12%)

Query: 410  STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
            ST  VLDR+     + ++V+     +  G +     V I V D NDN P F  ++Y   V
Sbjct: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 156

Query: 469  PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSIL------SGNVAGQFYLHSLSGILD 517
             E   + T +         ATD D G N  I Y I       + N   +  L  L+G + 
Sbjct: 157  NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-MLTGNIV 215

Query: 518  VINPLDFEDVQKYSLSIKAQDGGRPPLIN----SSGVVSVQVLDVNDNEPIFVSSPFQAT 573
            +   L++ED  +Y + I+A D  R   +N    ++  ++V VLD +D  P+F+       
Sbjct: 216  LRKRLNYEDKTRYFVIIQAND--RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273

Query: 574  VLENVPLGY--------------PVV---HIQAVDAD------SGENARLHYRLVDTAST 610
              +  PL Y              P++    IQA+D D      S     L+  LV T   
Sbjct: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT--- 330

Query: 611  FLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSS 670
                       P   P F F +H  +  +++   ++R+  + +   ++A      P+ + 
Sbjct: 331  -----------PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF 378

Query: 671  TSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV-- 719
              + I +LD N+  P FT P+Y+  + E A VG+++         L + A D+D      
Sbjct: 379  AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLIN 778
                L   +  + F ++       +TL  P+D +++Q Y  ++TA DG + S    V I 
Sbjct: 439  PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQ 498

Query: 779  VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRI 837
            V DAN + P F    Y V V  D   G S+  L+A D D G N  ITY ++      F I
Sbjct: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 558

Query: 838  DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLW 894
            +  +G +     ++      Y LT+ A DN  P  +++   T+ I +L  N+ + P+F  
Sbjct: 559  NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 618

Query: 895  DFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR 954
              Y   I E       +L + ATDR+      + Y  + GD     F +  T+G++   +
Sbjct: 619  LMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGK 674

Query: 955  RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEEN 1011
             LDRE+   Y L   A D G P   S +  + + + D+NDNAP+F+      L +  EE 
Sbjct: 675  ALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
            N   + V +++A DPD G N Q+ Y +  G+  + F++   NG +   V+L+ EVR  Y 
Sbjct: 733  N---AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYE 786

Query: 1072 LVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCI 1127
            LVV AT     P  S  T+ I ++D +DN PV  +     + Y      + P G  I  I
Sbjct: 787  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQI 841

Query: 1128 PAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIH 1185
             A D D+  +++Y            L P TGEL L R LD     EA    E S++  + 
Sbjct: 842  EAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVE 897

Query: 1186 SVTAFCTL-----RVTIITDDM 1202
            +   + T+      VT+I  DM
Sbjct: 898  AFDIYGTMPPGIATVTVIVKDM 919


>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
          Length = 1932

 Score =  268 bits (685), Expect = 6e-71
 Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)

Query: 245  FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
            F MP+YQ  + E+ P G  I   L L +   I   ++ +    +         Y  + + 
Sbjct: 373  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 432

Query: 302  TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
            T    T  +     +DRE ++T+   + A D      S    + + V D ND++P F + 
Sbjct: 433  TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 490

Query: 357  EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
             Y   V  ++  G  V+ + A D D   N  + Y +L GA   F +N+++G+++    ++
Sbjct: 491  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 550

Query: 417  REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475
                  Y L V+A D        ++  TVYIEV    N + P+F +  Y +++ E + + 
Sbjct: 551  MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 610

Query: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
              +L +QATDR+     +I Y+I +G+    F L   +GIL +   LD E   +Y L I 
Sbjct: 611  AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 667

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594
            A DG   P   S+  V++ V DVNDN P+F    P   +V+E     + V  ++A D D+
Sbjct: 668  ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 724

Query: 595  GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
            G N ++HY L +  + F                       S+G I    +L+RE  ++Y 
Sbjct: 725  GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 764

Query: 655  FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
              V A D    P  S+ +++I VLD++DN PVFT  TY + + E+   G+++L ++A+D 
Sbjct: 765  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 824

Query: 715  DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768
            D  + ++Y++     ++ FAL    G   ++L   LDY+    QE      V A D  GT
Sbjct: 825  DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 882

Query: 769  R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825
                 A V + V D N + PVF    Y   V+ D   GT I T+ A D D      +R+ 
Sbjct: 883  MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 942

Query: 826  YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
            Y + D     P   F ++ DSG + T + L+ E    + L ++A D+G P  S + T++I
Sbjct: 943  YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1002

Query: 881  LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
            L+L   +  P+F  + Y+   + E A   T +  +SA    +  N  ++Y+   G++ D 
Sbjct: 1003 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1056

Query: 940  DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992
             F I   +GVI     LD E    Y       +L  +  +   P+  S + ++ + I D 
Sbjct: 1057 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1115

Query: 993  NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047
            N++ P+F+K      V E+  + + V +++A D D G  + + Y+++     EG  +  F
Sbjct: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1173

Query: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
             ++   G ++  + L   +RR Y    V+        L  +A V + +V+Q D
Sbjct: 1174 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225



 Score =  265 bits (677), Expect = 5e-70
 Identities = 244/864 (28%), Positives = 392/864 (45%), Gaps = 105/864 (12%)

Query: 306  STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
            ST  VLDR+        V  V           Y  + ++V+D ND+SP F+   Y   V 
Sbjct: 76   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 135

Query: 364  ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412
            E   VG  + T       A+D D   N  + Y +        + D F++    +G +  R
Sbjct: 136  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195

Query: 413  AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465
              L+ E+   Y ++++AND+ +N     + T T+ ++V D +D  P F     V      
Sbjct: 196  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 255

Query: 466  -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506
                       ++ PE++        +QA D+D+          I YSIL G        
Sbjct: 256  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 315

Query: 507  FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
            F++H  +  L ++ P++ +  QK+ L IKA+     PL   +G + +++LD N+  P F 
Sbjct: 316  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 374

Query: 567  SSPFQATVLENVPLGYPV---------VHIQAVDAD--SGENARLHYRLVDTASTFLGGG 615
               +Q  +LE+ P+G  +         + I A+D D    ++  LH  L D  S F    
Sbjct: 375  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 434

Query: 616  SAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSI 675
            +                   + ++T+   +DREE + Y+F + A D      S    V+I
Sbjct: 435  T-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNI 475

Query: 676  TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733
             V+D NDN P F + +Y++ +  D   G SV+ L A D D  +N  ITY++  G  +  F
Sbjct: 476  QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDF 534

Query: 734  ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV 788
             ++  +  GLIT+A  ++    + Y L V A+D       R+    V I V   N   P 
Sbjct: 535  IIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 592

Query: 789  -FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMY 845
             F    Y++ +SE   VG  +  L A D    E   ITY I++  PQ  F +   +G + 
Sbjct: 593  RFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILT 649

Query: 846  TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905
                LD E+   Y L I A D G P  + T T+ I++ D NDNAP F     +     + 
Sbjct: 650  LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 708

Query: 906  PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYN 965
              +  + QV ATD D+G NG++ Y+         + +   ++G I T  +L+RE    Y 
Sbjct: 709  EANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYE 764

Query: 966  LWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRAND 1025
            L  +A D G+  P  +++ + + +LDI+DN+P+F      + VEEN P G+ + +I A D
Sbjct: 765  LVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 823

Query: 1026 PDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA----- 1076
             D G N  + Y+I   +++HFF L    G+L  +  LD+E           +V+A     
Sbjct: 824  VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 881

Query: 1077 TSAPLVSRATVHILLVDQNDNPPV 1100
            T  P +  ATV +++ D ND PPV
Sbjct: 882  TMPPGI--ATVTVIVKDMNDYPPV 903



 Score =  252 bits (644), Expect = 3e-66
 Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
            +F +   T  +S    ++R+  +   L +KA   +  P  A   + + + D N+ SP F 
Sbjct: 315  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 374

Query: 355  QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
               Y+  + E+  VG  +         L I A D+D     +    + L     VF + +
Sbjct: 375  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 434

Query: 405  SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
             +G+     +L   DREE   Y   + A D  +   P+     V I+V D NDN P F E
Sbjct: 435  -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 489

Query: 462  QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
             +Y V V  D+    +V+++ A D D+G N  I Y IL G   G F ++  +G++ +   
Sbjct: 490  ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 548

Query: 522  LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579
            ++    + Y+L+++A D   P    NS   V ++VL  N+ + P F    +   + E + 
Sbjct: 549  VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 608

Query: 580  LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
            +G  ++++QA D +            D+ +  +  G          P   F +  ++G +
Sbjct: 609  VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 648

Query: 640  TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698
            T+   LDRE  + Y   + A D G P  +S+ +V+I V DVNDN PVF  P     L+  
Sbjct: 649  TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 706

Query: 699  DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756
            +    + V  ++A D DA  N  + Y L  GN  N F ++S    G I  A+ L+ +   
Sbjct: 707  EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 761

Query: 757  QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
             Y L V A+DG    R  T  + I V D + + PVF +S YTV V E+ P GT+I  + A
Sbjct: 762  YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 821

Query: 814  NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867
             D D G N  ++Y I+ P  +  F + P +G +  +  LDYE     + + T  + A D 
Sbjct: 822  KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 879

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925
                     T+ +++ D ND  P F    Y+G +  DA   T I  V A D D    P  
Sbjct: 880  YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 939

Query: 926  RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980
            R+ Y     DD         F +E  SG + T+  L+ E   ++ L  +A D G P  +S
Sbjct: 940  RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 995

Query: 981  ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
            +S  +++ +L   +  P F ++E     V E    G++V  I A       N  I+Y IV
Sbjct: 996  SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1050

Query: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089
             G+    F ++ + G +     LD+E R  YVL VQA S  +V          + A V+I
Sbjct: 1051 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1110

Query: 1090 LLVDQNDNPPV 1100
             + D+N++PPV
Sbjct: 1111 EIQDENNHPPV 1121



 Score =  226 bits (575), Expect = 3e-58
 Identities = 239/862 (27%), Positives = 379/862 (43%), Gaps = 109/862 (12%)

Query: 410  STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
            ST  VLDR+     + ++V+     +  G +     V I V D NDN P F  ++Y   V
Sbjct: 76   STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 134

Query: 469  PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSIL------SGNVAGQFYLHSLSGILD 517
             E   + T +         ATD D G N  I Y I       + N   +  L  L+G + 
Sbjct: 135  NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-MLTGNIV 193

Query: 518  VINPLDFEDVQKYSLSIKAQDGGRPPLIN----SSGVVSVQVLDVNDNEPIFVSSPFQAT 573
            +   L++ED  +Y + I+A D  R   +N    ++  ++V VLD +D  P+F+       
Sbjct: 194  LRKRLNYEDKTRYFVIIQAND--RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 251

Query: 574  VLENVPLGY--------------PVV---HIQAVDAD------SGENARLHYRLVDTAST 610
              +  PL Y              P++    IQA+D D      S     L+  LV T   
Sbjct: 252  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT--- 308

Query: 611  FLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSS 670
                       P   P F F +H  +  +++   ++R+  + +   ++A      P+ + 
Sbjct: 309  -----------PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF 356

Query: 671  TSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV-- 719
              + I +LD N+  P FT P+Y+  + E A VG+++         L + A D+D      
Sbjct: 357  AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 416

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLIN 778
                L   +  + F ++       +TL  P+D +++Q Y  ++TA DG + S    V I 
Sbjct: 417  PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQ 476

Query: 779  VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRI 837
            V DAN + P F    Y V V  D   G S+  L+A D D G N  ITY ++      F I
Sbjct: 477  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 536

Query: 838  DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLW 894
            +  +G +     ++      Y LT+ A DN  P  +++   T+ I +L  N+ + P+F  
Sbjct: 537  NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 596

Query: 895  DFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR 954
              Y   I E       +L + ATDR+      + Y  + GD     F +  T+G++   +
Sbjct: 597  LMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGK 652

Query: 955  RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEEN 1011
             LDRE+   Y L   A D G P   S +  + + + D+NDNAP+F+      L +  EE 
Sbjct: 653  ALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710

Query: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
            N   + V +++A DPD G N Q+ Y +  G+  + F++   NG +   V+L+ EVR  Y 
Sbjct: 711  N---AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYE 764

Query: 1072 LVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCI 1127
            LVV AT     P  S  T+ I ++D +DN PV  +     + Y      + P G  I  I
Sbjct: 765  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQI 819

Query: 1128 PAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIH 1185
             A D D+  +++Y            L P TGEL L R LD     EA    E S++  + 
Sbjct: 820  EAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVE 875

Query: 1186 SVTAFCTL-----RVTIITDDM 1202
            +   + T+      VT+I  DM
Sbjct: 876  AFDIYGTMPPGIATVTVIVKDM 897


>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
          Length = 1677

 Score =  268 bits (685), Expect = 6e-71
 Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)

Query: 245  FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
            F MP+YQ  + E+ P G  I   L L +   I   ++ +    +         Y  + + 
Sbjct: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454

Query: 302  TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
            T    T  +     +DRE ++T+   + A D      S    + + V D ND++P F + 
Sbjct: 455  TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 512

Query: 357  EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
             Y   V  ++  G  V+ + A D D   N  + Y +L GA   F +N+++G+++    ++
Sbjct: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 572

Query: 417  REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475
                  Y L V+A D        ++  TVYIEV    N + P+F +  Y +++ E + + 
Sbjct: 573  MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 632

Query: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
              +L +QATDR+     +I Y+I +G+    F L   +GIL +   LD E   +Y L I 
Sbjct: 633  AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 689

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594
            A DG   P   S+  V++ V DVNDN P+F    P   +V+E     + V  ++A D D+
Sbjct: 690  ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 746

Query: 595  GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
            G N ++HY L +  + F                       S+G I    +L+RE  ++Y 
Sbjct: 747  GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 786

Query: 655  FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
              V A D    P  S+ +++I VLD++DN PVFT  TY + + E+   G+++L ++A+D 
Sbjct: 787  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846

Query: 715  DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768
            D  + ++Y++     ++ FAL    G   ++L   LDY+    QE      V A D  GT
Sbjct: 847  DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 904

Query: 769  R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825
                 A V + V D N + PVF    Y   V+ D   GT I T+ A D D      +R+ 
Sbjct: 905  MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964

Query: 826  YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
            Y + D     P   F ++ DSG + T + L+ E    + L ++A D+G P  S + T++I
Sbjct: 965  YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024

Query: 881  LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
            L+L   +  P+F  + Y+   + E A   T +  +SA    +  N  ++Y+   G++ D 
Sbjct: 1025 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1078

Query: 940  DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992
             F I   +GVI     LD E    Y       +L  +  +   P+  S + ++ + I D 
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1137

Query: 993  NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047
            N++ P+F+K      V E+  + + V +++A D D G  + + Y+++     EG  +  F
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1195

Query: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
             ++   G ++  + L   +RR Y    V+        L  +A V + +V+Q D
Sbjct: 1196 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247



 Score =  265 bits (677), Expect = 5e-70
 Identities = 244/864 (28%), Positives = 392/864 (45%), Gaps = 105/864 (12%)

Query: 306  STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
            ST  VLDR+        V  V           Y  + ++V+D ND+SP F+   Y   V 
Sbjct: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157

Query: 364  ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412
            E   VG  + T       A+D D   N  + Y +        + D F++    +G +  R
Sbjct: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217

Query: 413  AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465
              L+ E+   Y ++++AND+ +N     + T T+ ++V D +D  P F     V      
Sbjct: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277

Query: 466  -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506
                       ++ PE++        +QA D+D+          I YSIL G        
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337

Query: 507  FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
            F++H  +  L ++ P++ +  QK+ L IKA+     PL   +G + +++LD N+  P F 
Sbjct: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 396

Query: 567  SSPFQATVLENVPLGYPV---------VHIQAVDAD--SGENARLHYRLVDTASTFLGGG 615
               +Q  +LE+ P+G  +         + I A+D D    ++  LH  L D  S F    
Sbjct: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 616  SAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSI 675
            +                   + ++T+   +DREE + Y+F + A D      S    V+I
Sbjct: 457  T-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNI 497

Query: 676  TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733
             V+D NDN P F + +Y++ +  D   G SV+ L A D D  +N  ITY++  G  +  F
Sbjct: 498  QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDF 556

Query: 734  ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV 788
             ++  +  GLIT+A  ++    + Y L V A+D       R+    V I V   N   P 
Sbjct: 557  IIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614

Query: 789  -FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMY 845
             F    Y++ +SE   VG  +  L A D    E   ITY I++  PQ  F +   +G + 
Sbjct: 615  RFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILT 671

Query: 846  TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905
                LD E+   Y L I A D G P  + T T+ I++ D NDNAP F     +     + 
Sbjct: 672  LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730

Query: 906  PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYN 965
              +  + QV ATD D+G NG++ Y+         + +   ++G I T  +L+RE    Y 
Sbjct: 731  EANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYE 786

Query: 966  LWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRAND 1025
            L  +A D G+  P  +++ + + +LDI+DN+P+F      + VEEN P G+ + +I A D
Sbjct: 787  LVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845

Query: 1026 PDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA----- 1076
             D G N  + Y+I   +++HFF L    G+L  +  LD+E           +V+A     
Sbjct: 846  VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903

Query: 1077 TSAPLVSRATVHILLVDQNDNPPV 1100
            T  P +  ATV +++ D ND PPV
Sbjct: 904  TMPPGI--ATVTVIVKDMNDYPPV 925



 Score =  252 bits (644), Expect = 3e-66
 Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
            +F +   T  +S    ++R+  +   L +KA   +  P  A   + + + D N+ SP F 
Sbjct: 337  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396

Query: 355  QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
               Y+  + E+  VG  +         L I A D+D     +    + L     VF + +
Sbjct: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 405  SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
             +G+     +L   DREE   Y   + A D  +   P+     V I+V D NDN P F E
Sbjct: 457  -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 511

Query: 462  QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
             +Y V V  D+    +V+++ A D D+G N  I Y IL G   G F ++  +G++ +   
Sbjct: 512  ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 570

Query: 522  LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579
            ++    + Y+L+++A D   P    NS   V ++VL  N+ + P F    +   + E + 
Sbjct: 571  VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630

Query: 580  LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
            +G  ++++QA D +            D+ +  +  G          P   F +  ++G +
Sbjct: 631  VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 670

Query: 640  TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698
            T+   LDRE  + Y   + A D G P  +S+ +V+I V DVNDN PVF  P     L+  
Sbjct: 671  TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 728

Query: 699  DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756
            +    + V  ++A D DA  N  + Y L  GN  N F ++S    G I  A+ L+ +   
Sbjct: 729  EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 783

Query: 757  QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
             Y L V A+DG    R  T  + I V D + + PVF +S YTV V E+ P GT+I  + A
Sbjct: 784  YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843

Query: 814  NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867
             D D G N  ++Y I+ P  +  F + P +G +  +  LDYE     + + T  + A D 
Sbjct: 844  KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925
                     T+ +++ D ND  P F    Y+G +  DA   T I  V A D D    P  
Sbjct: 902  YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961

Query: 926  RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980
            R+ Y     DD         F +E  SG + T+  L+ E   ++ L  +A D G P  +S
Sbjct: 962  RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 1017

Query: 981  ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
            +S  +++ +L   +  P F ++E     V E    G++V  I A       N  I+Y IV
Sbjct: 1018 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1072

Query: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089
             G+    F ++ + G +     LD+E R  YVL VQA S  +V          + A V+I
Sbjct: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132

Query: 1090 LLVDQNDNPPV 1100
             + D+N++PPV
Sbjct: 1133 EIQDENNHPPV 1143



 Score =  226 bits (575), Expect = 3e-58
 Identities = 239/862 (27%), Positives = 379/862 (43%), Gaps = 109/862 (12%)

Query: 410  STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
            ST  VLDR+     + ++V+     +  G +     V I V D NDN P F  ++Y   V
Sbjct: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 156

Query: 469  PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSIL------SGNVAGQFYLHSLSGILD 517
             E   + T +         ATD D G N  I Y I       + N   +  L  L+G + 
Sbjct: 157  NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-MLTGNIV 215

Query: 518  VINPLDFEDVQKYSLSIKAQDGGRPPLIN----SSGVVSVQVLDVNDNEPIFVSSPFQAT 573
            +   L++ED  +Y + I+A D  R   +N    ++  ++V VLD +D  P+F+       
Sbjct: 216  LRKRLNYEDKTRYFVIIQAND--RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273

Query: 574  VLENVPLGY--------------PVV---HIQAVDAD------SGENARLHYRLVDTAST 610
              +  PL Y              P++    IQA+D D      S     L+  LV T   
Sbjct: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT--- 330

Query: 611  FLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSS 670
                       P   P F F +H  +  +++   ++R+  + +   ++A      P+ + 
Sbjct: 331  -----------PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF 378

Query: 671  TSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV-- 719
              + I +LD N+  P FT P+Y+  + E A VG+++         L + A D+D      
Sbjct: 379  AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLIN 778
                L   +  + F ++       +TL  P+D +++Q Y  ++TA DG + S    V I 
Sbjct: 439  PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQ 498

Query: 779  VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRI 837
            V DAN + P F    Y V V  D   G S+  L+A D D G N  ITY ++      F I
Sbjct: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 558

Query: 838  DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLW 894
            +  +G +     ++      Y LT+ A DN  P  +++   T+ I +L  N+ + P+F  
Sbjct: 559  NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 618

Query: 895  DFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR 954
              Y   I E       +L + ATDR+      + Y  + GD     F +  T+G++   +
Sbjct: 619  LMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGK 674

Query: 955  RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEEN 1011
             LDRE+   Y L   A D G P   S +  + + + D+NDNAP+F+      L +  EE 
Sbjct: 675  ALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
            N   + V +++A DPD G N Q+ Y +  G+  + F++   NG +   V+L+ EVR  Y 
Sbjct: 733  N---AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYE 786

Query: 1072 LVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCI 1127
            LVV AT     P  S  T+ I ++D +DN PV  +     + Y      + P G  I  I
Sbjct: 787  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQI 841

Query: 1128 PAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIH 1185
             A D D+  +++Y            L P TGEL L R LD     EA    E S++  + 
Sbjct: 842  EAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVE 897

Query: 1186 SVTAFCTL-----RVTIITDDM 1202
            +   + T+      VT+I  DM
Sbjct: 898  AFDIYGTMPPGIATVTVIVKDM 919


>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
          Length = 1682

 Score =  268 bits (685), Expect = 6e-71
 Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)

Query: 245  FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
            F MP+YQ  + E+ P G  I   L L +   I   ++ +    +         Y  + + 
Sbjct: 400  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 459

Query: 302  TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
            T    T  +     +DRE ++T+   + A D      S    + + V D ND++P F + 
Sbjct: 460  TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 517

Query: 357  EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
             Y   V  ++  G  V+ + A D D   N  + Y +L GA   F +N+++G+++    ++
Sbjct: 518  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 577

Query: 417  REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475
                  Y L V+A D        ++  TVYIEV    N + P+F +  Y +++ E + + 
Sbjct: 578  MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 637

Query: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
              +L +QATDR+     +I Y+I +G+    F L   +GIL +   LD E   +Y L I 
Sbjct: 638  AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 694

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594
            A DG   P   S+  V++ V DVNDN P+F    P   +V+E     + V  ++A D D+
Sbjct: 695  ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 751

Query: 595  GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
            G N ++HY L +  + F                       S+G I    +L+RE  ++Y 
Sbjct: 752  GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 791

Query: 655  FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
              V A D    P  S+ +++I VLD++DN PVFT  TY + + E+   G+++L ++A+D 
Sbjct: 792  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 851

Query: 715  DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768
            D  + ++Y++     ++ FAL    G   ++L   LDY+    QE      V A D  GT
Sbjct: 852  DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 909

Query: 769  R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825
                 A V + V D N + PVF    Y   V+ D   GT I T+ A D D      +R+ 
Sbjct: 910  MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 969

Query: 826  YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
            Y + D     P   F ++ DSG + T + L+ E    + L ++A D+G P  S + T++I
Sbjct: 970  YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1029

Query: 881  LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
            L+L   +  P+F  + Y+   + E A   T +  +SA    +  N  ++Y+   G++ D 
Sbjct: 1030 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1083

Query: 940  DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992
             F I   +GVI     LD E    Y       +L  +  +   P+  S + ++ + I D 
Sbjct: 1084 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1142

Query: 993  NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047
            N++ P+F+K      V E+  + + V +++A D D G  + + Y+++     EG  +  F
Sbjct: 1143 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1200

Query: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
             ++   G ++  + L   +RR Y    V+        L  +A V + +V+Q D
Sbjct: 1201 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252



 Score =  265 bits (677), Expect = 5e-70
 Identities = 244/864 (28%), Positives = 392/864 (45%), Gaps = 105/864 (12%)

Query: 306  STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
            ST  VLDR+        V  V           Y  + ++V+D ND+SP F+   Y   V 
Sbjct: 103  STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 162

Query: 364  ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412
            E   VG  + T       A+D D   N  + Y +        + D F++    +G +  R
Sbjct: 163  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222

Query: 413  AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465
              L+ E+   Y ++++AND+ +N     + T T+ ++V D +D  P F     V      
Sbjct: 223  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282

Query: 466  -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506
                       ++ PE++        +QA D+D+          I YSIL G        
Sbjct: 283  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342

Query: 507  FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
            F++H  +  L ++ P++ +  QK+ L IKA+     PL   +G + +++LD N+  P F 
Sbjct: 343  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 401

Query: 567  SSPFQATVLENVPLGYPV---------VHIQAVDAD--SGENARLHYRLVDTASTFLGGG 615
               +Q  +LE+ P+G  +         + I A+D D    ++  LH  L D  S F    
Sbjct: 402  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 461

Query: 616  SAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSI 675
            +                   + ++T+   +DREE + Y+F + A D      S    V+I
Sbjct: 462  T-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNI 502

Query: 676  TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733
             V+D NDN P F + +Y++ +  D   G SV+ L A D D  +N  ITY++  G  +  F
Sbjct: 503  QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDF 561

Query: 734  ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV 788
             ++  +  GLIT+A  ++    + Y L V A+D       R+    V I V   N   P 
Sbjct: 562  IIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 619

Query: 789  -FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMY 845
             F    Y++ +SE   VG  +  L A D    E   ITY I++  PQ  F +   +G + 
Sbjct: 620  RFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILT 676

Query: 846  TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905
                LD E+   Y L I A D G P  + T T+ I++ D NDNAP F     +     + 
Sbjct: 677  LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 735

Query: 906  PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYN 965
              +  + QV ATD D+G NG++ Y+         + +   ++G I T  +L+RE    Y 
Sbjct: 736  EANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYE 791

Query: 966  LWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRAND 1025
            L  +A D G+  P  +++ + + +LDI+DN+P+F      + VEEN P G+ + +I A D
Sbjct: 792  LVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 850

Query: 1026 PDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA----- 1076
             D G N  + Y+I   +++HFF L    G+L  +  LD+E           +V+A     
Sbjct: 851  VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 908

Query: 1077 TSAPLVSRATVHILLVDQNDNPPV 1100
            T  P +  ATV +++ D ND PPV
Sbjct: 909  TMPPGI--ATVTVIVKDMNDYPPV 930



 Score =  252 bits (644), Expect = 3e-66
 Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
            +F +   T  +S    ++R+  +   L +KA   +  P  A   + + + D N+ SP F 
Sbjct: 342  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 401

Query: 355  QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
               Y+  + E+  VG  +         L I A D+D     +    + L     VF + +
Sbjct: 402  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 461

Query: 405  SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
             +G+     +L   DREE   Y   + A D  +   P+     V I+V D NDN P F E
Sbjct: 462  -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 516

Query: 462  QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
             +Y V V  D+    +V+++ A D D+G N  I Y IL G   G F ++  +G++ +   
Sbjct: 517  ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 575

Query: 522  LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579
            ++    + Y+L+++A D   P    NS   V ++VL  N+ + P F    +   + E + 
Sbjct: 576  VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 635

Query: 580  LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
            +G  ++++QA D +            D+ +  +  G          P   F +  ++G +
Sbjct: 636  VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 675

Query: 640  TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698
            T+   LDRE  + Y   + A D G P  +S+ +V+I V DVNDN PVF  P     L+  
Sbjct: 676  TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 733

Query: 699  DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756
            +    + V  ++A D DA  N  + Y L  GN  N F ++S    G I  A+ L+ +   
Sbjct: 734  EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 788

Query: 757  QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
             Y L V A+DG    R  T  + I V D + + PVF +S YTV V E+ P GT+I  + A
Sbjct: 789  YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 848

Query: 814  NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867
             D D G N  ++Y I+ P  +  F + P +G +  +  LDYE     + + T  + A D 
Sbjct: 849  KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 906

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925
                     T+ +++ D ND  P F    Y+G +  DA   T I  V A D D    P  
Sbjct: 907  YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 966

Query: 926  RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980
            R+ Y     DD         F +E  SG + T+  L+ E   ++ L  +A D G P  +S
Sbjct: 967  RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 1022

Query: 981  ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
            +S  +++ +L   +  P F ++E     V E    G++V  I A       N  I+Y IV
Sbjct: 1023 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1077

Query: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089
             G+    F ++ + G +     LD+E R  YVL VQA S  +V          + A V+I
Sbjct: 1078 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1137

Query: 1090 LLVDQNDNPPV 1100
             + D+N++PPV
Sbjct: 1138 EIQDENNHPPV 1148



 Score =  226 bits (575), Expect = 3e-58
 Identities = 239/862 (27%), Positives = 379/862 (43%), Gaps = 109/862 (12%)

Query: 410  STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
            ST  VLDR+     + ++V+     +  G +     V I V D NDN P F  ++Y   V
Sbjct: 103  STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 161

Query: 469  PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSIL------SGNVAGQFYLHSLSGILD 517
             E   + T +         ATD D G N  I Y I       + N   +  L  L+G + 
Sbjct: 162  NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-MLTGNIV 220

Query: 518  VINPLDFEDVQKYSLSIKAQDGGRPPLIN----SSGVVSVQVLDVNDNEPIFVSSPFQAT 573
            +   L++ED  +Y + I+A D  R   +N    ++  ++V VLD +D  P+F+       
Sbjct: 221  LRKRLNYEDKTRYFVIIQAND--RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 278

Query: 574  VLENVPLGY--------------PVV---HIQAVDAD------SGENARLHYRLVDTAST 610
              +  PL Y              P++    IQA+D D      S     L+  LV T   
Sbjct: 279  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT--- 335

Query: 611  FLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSS 670
                       P   P F F +H  +  +++   ++R+  + +   ++A      P+ + 
Sbjct: 336  -----------PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF 383

Query: 671  TSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV-- 719
              + I +LD N+  P FT P+Y+  + E A VG+++         L + A D+D      
Sbjct: 384  AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 443

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLIN 778
                L   +  + F ++       +TL  P+D +++Q Y  ++TA DG + S    V I 
Sbjct: 444  PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQ 503

Query: 779  VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRI 837
            V DAN + P F    Y V V  D   G S+  L+A D D G N  ITY ++      F I
Sbjct: 504  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 563

Query: 838  DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLW 894
            +  +G +     ++      Y LT+ A DN  P  +++   T+ I +L  N+ + P+F  
Sbjct: 564  NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 623

Query: 895  DFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR 954
              Y   I E       +L + ATDR+      + Y  + GD     F +  T+G++   +
Sbjct: 624  LMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGK 679

Query: 955  RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEEN 1011
             LDRE+   Y L   A D G P   S +  + + + D+NDNAP+F+      L +  EE 
Sbjct: 680  ALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 737

Query: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
            N   + V +++A DPD G N Q+ Y +  G+  + F++   NG +   V+L+ EVR  Y 
Sbjct: 738  N---AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYE 791

Query: 1072 LVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCI 1127
            LVV AT     P  S  T+ I ++D +DN PV  +     + Y      + P G  I  I
Sbjct: 792  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQI 846

Query: 1128 PAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIH 1185
             A D D+  +++Y            L P TGEL L R LD     EA    E S++  + 
Sbjct: 847  EAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVE 902

Query: 1186 SVTAFCTL-----RVTIITDDM 1202
            +   + T+      VT+I  DM
Sbjct: 903  AFDIYGTMPPGIATVTVIVKDM 924


>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
          Length = 1539

 Score =  268 bits (685), Expect = 6e-71
 Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)

Query: 245  FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
            F MP+YQ  + E+ P G  I   L L +   I   ++ +    +         Y  + + 
Sbjct: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454

Query: 302  TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
            T    T  +     +DRE ++T+   + A D      S    + + V D ND++P F + 
Sbjct: 455  TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 512

Query: 357  EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
             Y   V  ++  G  V+ + A D D   N  + Y +L GA   F +N+++G+++    ++
Sbjct: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 572

Query: 417  REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475
                  Y L V+A D        ++  TVYIEV    N + P+F +  Y +++ E + + 
Sbjct: 573  MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 632

Query: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
              +L +QATDR+     +I Y+I +G+    F L   +GIL +   LD E   +Y L I 
Sbjct: 633  AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 689

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594
            A DG   P   S+  V++ V DVNDN P+F    P   +V+E     + V  ++A D D+
Sbjct: 690  ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 746

Query: 595  GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
            G N ++HY L +  + F                       S+G I    +L+RE  ++Y 
Sbjct: 747  GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 786

Query: 655  FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
              V A D    P  S+ +++I VLD++DN PVFT  TY + + E+   G+++L ++A+D 
Sbjct: 787  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846

Query: 715  DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768
            D  + ++Y++     ++ FAL    G   ++L   LDY+    QE      V A D  GT
Sbjct: 847  DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 904

Query: 769  R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825
                 A V + V D N + PVF    Y   V+ D   GT I T+ A D D      +R+ 
Sbjct: 905  MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964

Query: 826  YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
            Y + D     P   F ++ DSG + T + L+ E    + L ++A D+G P  S + T++I
Sbjct: 965  YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024

Query: 881  LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
            L+L   +  P+F  + Y+   + E A   T +  +SA    +  N  ++Y+   G++ D 
Sbjct: 1025 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1078

Query: 940  DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992
             F I   +GVI     LD E    Y       +L  +  +   P+  S + ++ + I D 
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1137

Query: 993  NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047
            N++ P+F+K      V E+  + + V +++A D D G  + + Y+++     EG  +  F
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1195

Query: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
             ++   G ++  + L   +RR Y    V+        L  +A V + +V+Q D
Sbjct: 1196 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247



 Score =  265 bits (677), Expect = 5e-70
 Identities = 244/864 (28%), Positives = 392/864 (45%), Gaps = 105/864 (12%)

Query: 306  STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
            ST  VLDR+        V  V           Y  + ++V+D ND+SP F+   Y   V 
Sbjct: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157

Query: 364  ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412
            E   VG  + T       A+D D   N  + Y +        + D F++    +G +  R
Sbjct: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217

Query: 413  AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465
              L+ E+   Y ++++AND+ +N     + T T+ ++V D +D  P F     V      
Sbjct: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277

Query: 466  -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506
                       ++ PE++        +QA D+D+          I YSIL G        
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337

Query: 507  FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
            F++H  +  L ++ P++ +  QK+ L IKA+     PL   +G + +++LD N+  P F 
Sbjct: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 396

Query: 567  SSPFQATVLENVPLGYPV---------VHIQAVDAD--SGENARLHYRLVDTASTFLGGG 615
               +Q  +LE+ P+G  +         + I A+D D    ++  LH  L D  S F    
Sbjct: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 616  SAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSI 675
            +                   + ++T+   +DREE + Y+F + A D      S    V+I
Sbjct: 457  T-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNI 497

Query: 676  TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733
             V+D NDN P F + +Y++ +  D   G SV+ L A D D  +N  ITY++  G  +  F
Sbjct: 498  QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDF 556

Query: 734  ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV 788
             ++  +  GLIT+A  ++    + Y L V A+D       R+    V I V   N   P 
Sbjct: 557  IIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614

Query: 789  -FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMY 845
             F    Y++ +SE   VG  +  L A D    E   ITY I++  PQ  F +   +G + 
Sbjct: 615  RFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILT 671

Query: 846  TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905
                LD E+   Y L I A D G P  + T T+ I++ D NDNAP F     +     + 
Sbjct: 672  LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730

Query: 906  PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYN 965
              +  + QV ATD D+G NG++ Y+         + +   ++G I T  +L+RE    Y 
Sbjct: 731  EANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYE 786

Query: 966  LWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRAND 1025
            L  +A D G+  P  +++ + + +LDI+DN+P+F      + VEEN P G+ + +I A D
Sbjct: 787  LVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845

Query: 1026 PDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA----- 1076
             D G N  + Y+I   +++HFF L    G+L  +  LD+E           +V+A     
Sbjct: 846  VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903

Query: 1077 TSAPLVSRATVHILLVDQNDNPPV 1100
            T  P +  ATV +++ D ND PPV
Sbjct: 904  TMPPGI--ATVTVIVKDMNDYPPV 925



 Score =  252 bits (644), Expect = 3e-66
 Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
            +F +   T  +S    ++R+  +   L +KA   +  P  A   + + + D N+ SP F 
Sbjct: 337  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396

Query: 355  QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
               Y+  + E+  VG  +         L I A D+D     +    + L     VF + +
Sbjct: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 405  SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
             +G+     +L   DREE   Y   + A D  +   P+     V I+V D NDN P F E
Sbjct: 457  -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 511

Query: 462  QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
             +Y V V  D+    +V+++ A D D+G N  I Y IL G   G F ++  +G++ +   
Sbjct: 512  ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 570

Query: 522  LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579
            ++    + Y+L+++A D   P    NS   V ++VL  N+ + P F    +   + E + 
Sbjct: 571  VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630

Query: 580  LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
            +G  ++++QA D +            D+ +  +  G          P   F +  ++G +
Sbjct: 631  VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 670

Query: 640  TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698
            T+   LDRE  + Y   + A D G P  +S+ +V+I V DVNDN PVF  P     L+  
Sbjct: 671  TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 728

Query: 699  DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756
            +    + V  ++A D DA  N  + Y L  GN  N F ++S    G I  A+ L+ +   
Sbjct: 729  EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 783

Query: 757  QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
             Y L V A+DG    R  T  + I V D + + PVF +S YTV V E+ P GT+I  + A
Sbjct: 784  YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843

Query: 814  NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867
             D D G N  ++Y I+ P  +  F + P +G +  +  LDYE     + + T  + A D 
Sbjct: 844  KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925
                     T+ +++ D ND  P F    Y+G +  DA   T I  V A D D    P  
Sbjct: 902  YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961

Query: 926  RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980
            R+ Y     DD         F +E  SG + T+  L+ E   ++ L  +A D G P  +S
Sbjct: 962  RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 1017

Query: 981  ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
            +S  +++ +L   +  P F ++E     V E    G++V  I A       N  I+Y IV
Sbjct: 1018 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1072

Query: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089
             G+    F ++ + G +     LD+E R  YVL VQA S  +V          + A V+I
Sbjct: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132

Query: 1090 LLVDQNDNPPV 1100
             + D+N++PPV
Sbjct: 1133 EIQDENNHPPV 1143



 Score =  226 bits (575), Expect = 3e-58
 Identities = 239/862 (27%), Positives = 379/862 (43%), Gaps = 109/862 (12%)

Query: 410  STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
            ST  VLDR+     + ++V+     +  G +     V I V D NDN P F  ++Y   V
Sbjct: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 156

Query: 469  PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSIL------SGNVAGQFYLHSLSGILD 517
             E   + T +         ATD D G N  I Y I       + N   +  L  L+G + 
Sbjct: 157  NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-MLTGNIV 215

Query: 518  VINPLDFEDVQKYSLSIKAQDGGRPPLIN----SSGVVSVQVLDVNDNEPIFVSSPFQAT 573
            +   L++ED  +Y + I+A D  R   +N    ++  ++V VLD +D  P+F+       
Sbjct: 216  LRKRLNYEDKTRYFVIIQAND--RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273

Query: 574  VLENVPLGY--------------PVV---HIQAVDAD------SGENARLHYRLVDTAST 610
              +  PL Y              P++    IQA+D D      S     L+  LV T   
Sbjct: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT--- 330

Query: 611  FLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSS 670
                       P   P F F +H  +  +++   ++R+  + +   ++A      P+ + 
Sbjct: 331  -----------PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF 378

Query: 671  TSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV-- 719
              + I +LD N+  P FT P+Y+  + E A VG+++         L + A D+D      
Sbjct: 379  AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLIN 778
                L   +  + F ++       +TL  P+D +++Q Y  ++TA DG + S    V I 
Sbjct: 439  PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQ 498

Query: 779  VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRI 837
            V DAN + P F    Y V V  D   G S+  L+A D D G N  ITY ++      F I
Sbjct: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 558

Query: 838  DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLW 894
            +  +G +     ++      Y LT+ A DN  P  +++   T+ I +L  N+ + P+F  
Sbjct: 559  NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 618

Query: 895  DFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR 954
              Y   I E       +L + ATDR+      + Y  + GD     F +  T+G++   +
Sbjct: 619  LMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGK 674

Query: 955  RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEEN 1011
             LDRE+   Y L   A D G P   S +  + + + D+NDNAP+F+      L +  EE 
Sbjct: 675  ALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
            N   + V +++A DPD G N Q+ Y +  G+  + F++   NG +   V+L+ EVR  Y 
Sbjct: 733  N---AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYE 786

Query: 1072 LVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCI 1127
            LVV AT     P  S  T+ I ++D +DN PV  +     + Y      + P G  I  I
Sbjct: 787  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQI 841

Query: 1128 PAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIH 1185
             A D D+  +++Y            L P TGEL L R LD     EA    E S++  + 
Sbjct: 842  EAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVE 897

Query: 1186 SVTAFCTL-----RVTIITDDM 1202
            +   + T+      VT+I  DM
Sbjct: 898  AFDIYGTMPPGIATVTVIVKDM 919


>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
          Length = 1935

 Score =  268 bits (685), Expect = 6e-71
 Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)

Query: 245  FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
            F MP+YQ  + E+ P G  I   L L +   I   ++ +    +         Y  + + 
Sbjct: 373  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 432

Query: 302  TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
            T    T  +     +DRE ++T+   + A D      S    + + V D ND++P F + 
Sbjct: 433  TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 490

Query: 357  EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
             Y   V  ++  G  V+ + A D D   N  + Y +L GA   F +N+++G+++    ++
Sbjct: 491  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 550

Query: 417  REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475
                  Y L V+A D        ++  TVYIEV    N + P+F +  Y +++ E + + 
Sbjct: 551  MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 610

Query: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
              +L +QATDR+     +I Y+I +G+    F L   +GIL +   LD E   +Y L I 
Sbjct: 611  AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 667

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594
            A DG   P   S+  V++ V DVNDN P+F    P   +V+E     + V  ++A D D+
Sbjct: 668  ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 724

Query: 595  GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
            G N ++HY L +  + F                       S+G I    +L+RE  ++Y 
Sbjct: 725  GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 764

Query: 655  FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
              V A D    P  S+ +++I VLD++DN PVFT  TY + + E+   G+++L ++A+D 
Sbjct: 765  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 824

Query: 715  DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768
            D  + ++Y++     ++ FAL    G   ++L   LDY+    QE      V A D  GT
Sbjct: 825  DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 882

Query: 769  R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825
                 A V + V D N + PVF    Y   V+ D   GT I T+ A D D      +R+ 
Sbjct: 883  MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 942

Query: 826  YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
            Y + D     P   F ++ DSG + T + L+ E    + L ++A D+G P  S + T++I
Sbjct: 943  YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1002

Query: 881  LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
            L+L   +  P+F  + Y+   + E A   T +  +SA    +  N  ++Y+   G++ D 
Sbjct: 1003 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1056

Query: 940  DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992
             F I   +GVI     LD E    Y       +L  +  +   P+  S + ++ + I D 
Sbjct: 1057 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1115

Query: 993  NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047
            N++ P+F+K      V E+  + + V +++A D D G  + + Y+++     EG  +  F
Sbjct: 1116 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1173

Query: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
             ++   G ++  + L   +RR Y    V+        L  +A V + +V+Q D
Sbjct: 1174 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225



 Score =  265 bits (677), Expect = 5e-70
 Identities = 244/864 (28%), Positives = 392/864 (45%), Gaps = 105/864 (12%)

Query: 306  STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
            ST  VLDR+        V  V           Y  + ++V+D ND+SP F+   Y   V 
Sbjct: 76   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 135

Query: 364  ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412
            E   VG  + T       A+D D   N  + Y +        + D F++    +G +  R
Sbjct: 136  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195

Query: 413  AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465
              L+ E+   Y ++++AND+ +N     + T T+ ++V D +D  P F     V      
Sbjct: 196  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 255

Query: 466  -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506
                       ++ PE++        +QA D+D+          I YSIL G        
Sbjct: 256  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 315

Query: 507  FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
            F++H  +  L ++ P++ +  QK+ L IKA+     PL   +G + +++LD N+  P F 
Sbjct: 316  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 374

Query: 567  SSPFQATVLENVPLGYPV---------VHIQAVDAD--SGENARLHYRLVDTASTFLGGG 615
               +Q  +LE+ P+G  +         + I A+D D    ++  LH  L D  S F    
Sbjct: 375  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 434

Query: 616  SAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSI 675
            +                   + ++T+   +DREE + Y+F + A D      S    V+I
Sbjct: 435  T-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNI 475

Query: 676  TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733
             V+D NDN P F + +Y++ +  D   G SV+ L A D D  +N  ITY++  G  +  F
Sbjct: 476  QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDF 534

Query: 734  ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV 788
             ++  +  GLIT+A  ++    + Y L V A+D       R+    V I V   N   P 
Sbjct: 535  IIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 592

Query: 789  -FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMY 845
             F    Y++ +SE   VG  +  L A D    E   ITY I++  PQ  F +   +G + 
Sbjct: 593  RFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILT 649

Query: 846  TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905
                LD E+   Y L I A D G P  + T T+ I++ D NDNAP F     +     + 
Sbjct: 650  LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 708

Query: 906  PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYN 965
              +  + QV ATD D+G NG++ Y+         + +   ++G I T  +L+RE    Y 
Sbjct: 709  EANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYE 764

Query: 966  LWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRAND 1025
            L  +A D G+  P  +++ + + +LDI+DN+P+F      + VEEN P G+ + +I A D
Sbjct: 765  LVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 823

Query: 1026 PDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA----- 1076
             D G N  + Y+I   +++HFF L    G+L  +  LD+E           +V+A     
Sbjct: 824  VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 881

Query: 1077 TSAPLVSRATVHILLVDQNDNPPV 1100
            T  P +  ATV +++ D ND PPV
Sbjct: 882  TMPPGI--ATVTVIVKDMNDYPPV 903



 Score =  252 bits (644), Expect = 3e-66
 Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
            +F +   T  +S    ++R+  +   L +KA   +  P  A   + + + D N+ SP F 
Sbjct: 315  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 374

Query: 355  QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
               Y+  + E+  VG  +         L I A D+D     +    + L     VF + +
Sbjct: 375  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 434

Query: 405  SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
             +G+     +L   DREE   Y   + A D  +   P+     V I+V D NDN P F E
Sbjct: 435  -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 489

Query: 462  QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
             +Y V V  D+    +V+++ A D D+G N  I Y IL G   G F ++  +G++ +   
Sbjct: 490  ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 548

Query: 522  LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579
            ++    + Y+L+++A D   P    NS   V ++VL  N+ + P F    +   + E + 
Sbjct: 549  VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 608

Query: 580  LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
            +G  ++++QA D +            D+ +  +  G          P   F +  ++G +
Sbjct: 609  VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 648

Query: 640  TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698
            T+   LDRE  + Y   + A D G P  +S+ +V+I V DVNDN PVF  P     L+  
Sbjct: 649  TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 706

Query: 699  DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756
            +    + V  ++A D DA  N  + Y L  GN  N F ++S    G I  A+ L+ +   
Sbjct: 707  EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 761

Query: 757  QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
             Y L V A+DG    R  T  + I V D + + PVF +S YTV V E+ P GT+I  + A
Sbjct: 762  YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 821

Query: 814  NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867
             D D G N  ++Y I+ P  +  F + P +G +  +  LDYE     + + T  + A D 
Sbjct: 822  KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 879

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925
                     T+ +++ D ND  P F    Y+G +  DA   T I  V A D D    P  
Sbjct: 880  YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 939

Query: 926  RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980
            R+ Y     DD         F +E  SG + T+  L+ E   ++ L  +A D G P  +S
Sbjct: 940  RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 995

Query: 981  ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
            +S  +++ +L   +  P F ++E     V E    G++V  I A       N  I+Y IV
Sbjct: 996  SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1050

Query: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089
             G+    F ++ + G +     LD+E R  YVL VQA S  +V          + A V+I
Sbjct: 1051 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1110

Query: 1090 LLVDQNDNPPV 1100
             + D+N++PPV
Sbjct: 1111 EIQDENNHPPV 1121



 Score =  226 bits (575), Expect = 3e-58
 Identities = 239/862 (27%), Positives = 379/862 (43%), Gaps = 109/862 (12%)

Query: 410  STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
            ST  VLDR+     + ++V+     +  G +     V I V D NDN P F  ++Y   V
Sbjct: 76   STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 134

Query: 469  PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSIL------SGNVAGQFYLHSLSGILD 517
             E   + T +         ATD D G N  I Y I       + N   +  L  L+G + 
Sbjct: 135  NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-MLTGNIV 193

Query: 518  VINPLDFEDVQKYSLSIKAQDGGRPPLIN----SSGVVSVQVLDVNDNEPIFVSSPFQAT 573
            +   L++ED  +Y + I+A D  R   +N    ++  ++V VLD +D  P+F+       
Sbjct: 194  LRKRLNYEDKTRYFVIIQAND--RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 251

Query: 574  VLENVPLGY--------------PVV---HIQAVDAD------SGENARLHYRLVDTAST 610
              +  PL Y              P++    IQA+D D      S     L+  LV T   
Sbjct: 252  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT--- 308

Query: 611  FLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSS 670
                       P   P F F +H  +  +++   ++R+  + +   ++A      P+ + 
Sbjct: 309  -----------PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF 356

Query: 671  TSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV-- 719
              + I +LD N+  P FT P+Y+  + E A VG+++         L + A D+D      
Sbjct: 357  AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 416

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLIN 778
                L   +  + F ++       +TL  P+D +++Q Y  ++TA DG + S    V I 
Sbjct: 417  PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQ 476

Query: 779  VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRI 837
            V DAN + P F    Y V V  D   G S+  L+A D D G N  ITY ++      F I
Sbjct: 477  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 536

Query: 838  DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLW 894
            +  +G +     ++      Y LT+ A DN  P  +++   T+ I +L  N+ + P+F  
Sbjct: 537  NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 596

Query: 895  DFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR 954
              Y   I E       +L + ATDR+      + Y  + GD     F +  T+G++   +
Sbjct: 597  LMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGK 652

Query: 955  RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEEN 1011
             LDRE+   Y L   A D G P   S +  + + + D+NDNAP+F+      L +  EE 
Sbjct: 653  ALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710

Query: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
            N   + V +++A DPD G N Q+ Y +  G+  + F++   NG +   V+L+ EVR  Y 
Sbjct: 711  N---AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYE 764

Query: 1072 LVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCI 1127
            LVV AT     P  S  T+ I ++D +DN PV  +     + Y      + P G  I  I
Sbjct: 765  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQI 819

Query: 1128 PAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIH 1185
             A D D+  +++Y            L P TGEL L R LD     EA    E S++  + 
Sbjct: 820  EAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVE 875

Query: 1186 SVTAFCTL-----RVTIITDDM 1202
            +   + T+      VT+I  DM
Sbjct: 876  AFDIYGTMPPGIATVTVIVKDM 897


>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
          Length = 1915

 Score =  268 bits (685), Expect = 6e-71
 Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)

Query: 245  FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
            F MP+YQ  + E+ P G  I   L L +   I   ++ +    +         Y  + + 
Sbjct: 358  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 417

Query: 302  TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
            T    T  +     +DRE ++T+   + A D      S    + + V D ND++P F + 
Sbjct: 418  TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 475

Query: 357  EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
             Y   V  ++  G  V+ + A D D   N  + Y +L GA   F +N+++G+++    ++
Sbjct: 476  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 535

Query: 417  REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475
                  Y L V+A D        ++  TVYIEV    N + P+F +  Y +++ E + + 
Sbjct: 536  MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 595

Query: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
              +L +QATDR+     +I Y+I +G+    F L   +GIL +   LD E   +Y L I 
Sbjct: 596  AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 652

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594
            A DG   P   S+  V++ V DVNDN P+F    P   +V+E     + V  ++A D D+
Sbjct: 653  ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 709

Query: 595  GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
            G N ++HY L +  + F                       S+G I    +L+RE  ++Y 
Sbjct: 710  GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 749

Query: 655  FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
              V A D    P  S+ +++I VLD++DN PVFT  TY + + E+   G+++L ++A+D 
Sbjct: 750  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 809

Query: 715  DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768
            D  + ++Y++     ++ FAL    G   ++L   LDY+    QE      V A D  GT
Sbjct: 810  DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 867

Query: 769  R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825
                 A V + V D N + PVF    Y   V+ D   GT I T+ A D D      +R+ 
Sbjct: 868  MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 927

Query: 826  YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
            Y + D     P   F ++ DSG + T + L+ E    + L ++A D+G P  S + T++I
Sbjct: 928  YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 987

Query: 881  LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
            L+L   +  P+F  + Y+   + E A   T +  +SA    +  N  ++Y+   G++ D 
Sbjct: 988  LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1041

Query: 940  DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992
             F I   +GVI     LD E    Y       +L  +  +   P+  S + ++ + I D 
Sbjct: 1042 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1100

Query: 993  NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047
            N++ P+F+K      V E+  + + V +++A D D G  + + Y+++     EG  +  F
Sbjct: 1101 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1158

Query: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
             ++   G ++  + L   +RR Y    V+        L  +A V + +V+Q D
Sbjct: 1159 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210



 Score =  252 bits (644), Expect = 3e-66
 Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
            +F +   T  +S    ++R+  +   L +KA   +  P  A   + + + D N+ SP F 
Sbjct: 300  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 359

Query: 355  QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
               Y+  + E+  VG  +         L I A D+D     +    + L     VF + +
Sbjct: 360  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 419

Query: 405  SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
             +G+     +L   DREE   Y   + A D  +   P+     V I+V D NDN P F E
Sbjct: 420  -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 474

Query: 462  QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
             +Y V V  D+    +V+++ A D D+G N  I Y IL G   G F ++  +G++ +   
Sbjct: 475  ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 533

Query: 522  LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579
            ++    + Y+L+++A D   P    NS   V ++VL  N+ + P F    +   + E + 
Sbjct: 534  VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 593

Query: 580  LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
            +G  ++++QA D +            D+ +  +  G          P   F +  ++G +
Sbjct: 594  VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 633

Query: 640  TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698
            T+   LDRE  + Y   + A D G P  +S+ +V+I V DVNDN PVF  P     L+  
Sbjct: 634  TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 691

Query: 699  DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756
            +    + V  ++A D DA  N  + Y L  GN  N F ++S    G I  A+ L+ +   
Sbjct: 692  EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 746

Query: 757  QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
             Y L V A+DG    R  T  + I V D + + PVF +S YTV V E+ P GT+I  + A
Sbjct: 747  YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 806

Query: 814  NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867
             D D G N  ++Y I+ P  +  F + P +G +  +  LDYE     + + T  + A D 
Sbjct: 807  KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 864

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925
                     T+ +++ D ND  P F    Y+G +  DA   T I  V A D D    P  
Sbjct: 865  YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 924

Query: 926  RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980
            R+ Y     DD         F +E  SG + T+  L+ E   ++ L  +A D G P  +S
Sbjct: 925  RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 980

Query: 981  ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
            +S  +++ +L   +  P F ++E     V E    G++V  I A       N  I+Y IV
Sbjct: 981  SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1035

Query: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089
             G+    F ++ + G +     LD+E R  YVL VQA S  +V          + A V+I
Sbjct: 1036 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1095

Query: 1090 LLVDQNDNPPV 1100
             + D+N++PPV
Sbjct: 1096 EIQDENNHPPV 1106



 Score =  250 bits (639), Expect = 1e-65
 Identities = 239/845 (28%), Positives = 376/845 (44%), Gaps = 104/845 (12%)

Query: 306  STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
            ST  VLDR+        V  V           Y  + ++V+D ND+SP F+   Y   V 
Sbjct: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157

Query: 364  ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGGAWD---VFQLNESSGVVSTRA-- 413
            E   VG  + T       A+D D   N  + Y +     D      LNE     +T    
Sbjct: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQNLNERRTTTTTLTVD 217

Query: 414  VLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVG 473
            VLD ++     L        R+  PL+  A +           P+       ++ PE++ 
Sbjct: 218  VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAI-----------PE-------LRTPEELN 259

Query: 474  LNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ---FYLHSLSGILDVINPLDFE 525
                   +QA D+D+          I YSIL G        F++H  +  L ++ P++ +
Sbjct: 260  PIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD 319

Query: 526  DVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV- 584
              QK+ L IKA+     PL   +G + +++LD N+  P F    +Q  +LE+ P+G  + 
Sbjct: 320  FHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 378

Query: 585  --------VHIQAVDAD--SGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHN 634
                    + I A+D D    ++  LH  L D  S F    +                  
Sbjct: 379  DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT-----------------G 421

Query: 635  SSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYEL 694
             + ++T+   +DREE + Y+F + A D      S    V+I V+D NDN P F + +Y++
Sbjct: 422  ITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDV 479

Query: 695  RLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDY 752
             +  D   G SV+ L A D D  +N  ITY++  G  +  F ++  +  GLIT+A  ++ 
Sbjct: 480  YVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEM 536

Query: 753  KQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV-FQSSHYTVSVSEDRPVGT 806
               + Y L V A+D       R+    V I V   N   P  F    Y++ +SE   VG 
Sbjct: 537  IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 596

Query: 807  SIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYENQVAYTLTIMA 864
             +  L A D    E   ITY I++  PQ  F +   +G +     LD E+   Y L I A
Sbjct: 597  VLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 653

Query: 865  QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924
             D G P  + T T+ I++ D NDNAP F     +     +   +  + QV ATD D+G N
Sbjct: 654  SD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 712

Query: 925  GRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVE 984
            G++ Y+         + +   ++G I T  +L+RE    Y L  +A D G+  P  +++ 
Sbjct: 713  GQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLT 767

Query: 985  IQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMR 1044
            + + +LDI+DN+P+F      + VEEN P G+ + +I A D D G N  + Y+I   +++
Sbjct: 768  LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVK 825

Query: 1045 HFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA-----TSAPLVSRATVHILLVDQN 1095
            HFF L    G+L  +  LD+E           +V+A     T  P +  ATV +++ D N
Sbjct: 826  HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI--ATVTVIVKDMN 883

Query: 1096 DNPPV 1100
            D PPV
Sbjct: 884  DYPPV 888



 Score =  211 bits (538), Expect = 7e-54
 Identities = 230/852 (26%), Positives = 361/852 (42%), Gaps = 126/852 (14%)

Query: 410  STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
            ST  VLDR+     + ++V+     +  G +     V I V D NDN P F  ++Y   V
Sbjct: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 156

Query: 469  PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLD 523
             E   + T +         ATD D G N  I Y I                     NP D
Sbjct: 157  NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ-------------------YNPDD 197

Query: 524  FEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGY- 582
             +  Q  +               ++  ++V VLD +D  P+F+         +  PL Y 
Sbjct: 198  PDRAQNLN-----------ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQ 246

Query: 583  -------------PVV---HIQAVDAD------SGENARLHYRLVDTASTFLGGGSAGPK 620
                         P++    IQA+D D      S     L+  LV T             
Sbjct: 247  AAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT------------- 293

Query: 621  NPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDV 680
             P   P F F +H  +  +++   ++R+  + +   ++A      P+ +   + I +LD 
Sbjct: 294  -PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDE 351

Query: 681  NDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV--ITYQLTGGNT 729
            N+  P FT P+Y+  + E A VG+++         L + A D+D          L   + 
Sbjct: 352  NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 411

Query: 730  RNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLINVTDANTHRPV 788
             + F ++       +TL  P+D +++Q Y  ++TA DG + S    V I V DAN + P 
Sbjct: 412  TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT 471

Query: 789  FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRIDPDSGTMYTM 847
            F    Y V V  D   G S+  L+A D D G N  ITY ++      F I+  +G +   
Sbjct: 472  FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIA 531

Query: 848  MELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLWDFYQGSIFED 904
              ++      Y LT+ A DN  P  +++   T+ I +L  N+ + P+F    Y   I E 
Sbjct: 532  PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEA 591

Query: 905  APPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVY 964
                  +L + ATDR+      + Y  + GD     F +  T+G++   + LDRE+   Y
Sbjct: 592  MRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRY 647

Query: 965  NLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEENNPVGSVVAKI 1021
             L   A D G P   S +  + + + D+NDNAP+F+      L +  EE N   + V ++
Sbjct: 648  ILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN---AFVGQV 702

Query: 1022 RANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSA-- 1079
            +A DPD G N Q+ Y +  G+  + F++   NG +   V+L+ EVR  Y LVV AT    
Sbjct: 703  KATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAV 759

Query: 1080 -PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCIPAHDPDVSDS 1137
             P  S  T+ I ++D +DN PV  +     + Y      + P G  I  I A D D+  +
Sbjct: 760  HPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQIEAKDVDLGAN 814

Query: 1138 LNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIHSVTAFCTL-- 1193
            ++Y            L P TGEL L R LD     EA    E S++  + +   + T+  
Sbjct: 815  VSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVEAFDIYGTMPP 870

Query: 1194 ---RVTIITDDM 1202
                VT+I  DM
Sbjct: 871  GIATVTVIVKDM 882


>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
          Length = 1952

 Score =  268 bits (685), Expect = 6e-71
 Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)

Query: 245  FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
            F MP+YQ  + E+ P G  I   L L +   I   ++ +    +         Y  + + 
Sbjct: 395  FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454

Query: 302  TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
            T    T  +     +DRE ++T+   + A D      S    + + V D ND++P F + 
Sbjct: 455  TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 512

Query: 357  EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
             Y   V  ++  G  V+ + A D D   N  + Y +L GA   F +N+++G+++    ++
Sbjct: 513  SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 572

Query: 417  REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475
                  Y L V+A D        ++  TVYIEV    N + P+F +  Y +++ E + + 
Sbjct: 573  MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 632

Query: 476  TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
              +L +QATDR+     +I Y+I +G+    F L   +GIL +   LD E   +Y L I 
Sbjct: 633  AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 689

Query: 536  AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594
            A DG   P   S+  V++ V DVNDN P+F    P   +V+E     + V  ++A D D+
Sbjct: 690  ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 746

Query: 595  GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
            G N ++HY L +  + F                       S+G I    +L+RE  ++Y 
Sbjct: 747  GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 786

Query: 655  FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
              V A D    P  S+ +++I VLD++DN PVFT  TY + + E+   G+++L ++A+D 
Sbjct: 787  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846

Query: 715  DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768
            D  + ++Y++     ++ FAL    G   ++L   LDY+    QE      V A D  GT
Sbjct: 847  DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 904

Query: 769  R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825
                 A V + V D N + PVF    Y   V+ D   GT I T+ A D D      +R+ 
Sbjct: 905  MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964

Query: 826  YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
            Y + D     P   F ++ DSG + T + L+ E    + L ++A D+G P  S + T++I
Sbjct: 965  YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024

Query: 881  LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
            L+L   +  P+F  + Y+   + E A   T +  +SA    +  N  ++Y+   G++ D 
Sbjct: 1025 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1078

Query: 940  DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992
             F I   +GVI     LD E    Y       +L  +  +   P+  S + ++ + I D 
Sbjct: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1137

Query: 993  NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047
            N++ P+F+K      V E+  + + V +++A D D G  + + Y+++     EG  +  F
Sbjct: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1195

Query: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
             ++   G ++  + L   +RR Y    V+        L  +A V + +V+Q D
Sbjct: 1196 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247



 Score =  265 bits (677), Expect = 5e-70
 Identities = 244/864 (28%), Positives = 392/864 (45%), Gaps = 105/864 (12%)

Query: 306  STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
            ST  VLDR+        V  V           Y  + ++V+D ND+SP F+   Y   V 
Sbjct: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157

Query: 364  ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412
            E   VG  + T       A+D D   N  + Y +        + D F++    +G +  R
Sbjct: 158  ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217

Query: 413  AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465
              L+ E+   Y ++++AND+ +N     + T T+ ++V D +D  P F     V      
Sbjct: 218  KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277

Query: 466  -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506
                       ++ PE++        +QA D+D+          I YSIL G        
Sbjct: 278  RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337

Query: 507  FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
            F++H  +  L ++ P++ +  QK+ L IKA+     PL   +G + +++LD N+  P F 
Sbjct: 338  FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 396

Query: 567  SSPFQATVLENVPLGYPV---------VHIQAVDAD--SGENARLHYRLVDTASTFLGGG 615
               +Q  +LE+ P+G  +         + I A+D D    ++  LH  L D  S F    
Sbjct: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 616  SAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSI 675
            +                   + ++T+   +DREE + Y+F + A D      S    V+I
Sbjct: 457  T-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNI 497

Query: 676  TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733
             V+D NDN P F + +Y++ +  D   G SV+ L A D D  +N  ITY++  G  +  F
Sbjct: 498  QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDF 556

Query: 734  ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV 788
             ++  +  GLIT+A  ++    + Y L V A+D       R+    V I V   N   P 
Sbjct: 557  IIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614

Query: 789  -FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMY 845
             F    Y++ +SE   VG  +  L A D    E   ITY I++  PQ  F +   +G + 
Sbjct: 615  RFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILT 671

Query: 846  TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905
                LD E+   Y L I A D G P  + T T+ I++ D NDNAP F     +     + 
Sbjct: 672  LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730

Query: 906  PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYN 965
              +  + QV ATD D+G NG++ Y+         + +   ++G I T  +L+RE    Y 
Sbjct: 731  EANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYE 786

Query: 966  LWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRAND 1025
            L  +A D G+  P  +++ + + +LDI+DN+P+F      + VEEN P G+ + +I A D
Sbjct: 787  LVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845

Query: 1026 PDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA----- 1076
             D G N  + Y+I   +++HFF L    G+L  +  LD+E           +V+A     
Sbjct: 846  VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903

Query: 1077 TSAPLVSRATVHILLVDQNDNPPV 1100
            T  P +  ATV +++ D ND PPV
Sbjct: 904  TMPPGI--ATVTVIVKDMNDYPPV 925



 Score =  252 bits (644), Expect = 3e-66
 Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)

Query: 295  YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
            +F +   T  +S    ++R+  +   L +KA   +  P  A   + + + D N+ SP F 
Sbjct: 337  FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396

Query: 355  QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
               Y+  + E+  VG  +         L I A D+D     +    + L     VF + +
Sbjct: 397  MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456

Query: 405  SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
             +G+     +L   DREE   Y   + A D  +   P+     V I+V D NDN P F E
Sbjct: 457  -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 511

Query: 462  QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
             +Y V V  D+    +V+++ A D D+G N  I Y IL G   G F ++  +G++ +   
Sbjct: 512  ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 570

Query: 522  LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579
            ++    + Y+L+++A D   P    NS   V ++VL  N+ + P F    +   + E + 
Sbjct: 571  VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630

Query: 580  LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
            +G  ++++QA D +            D+ +  +  G          P   F +  ++G +
Sbjct: 631  VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 670

Query: 640  TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698
            T+   LDRE  + Y   + A D G P  +S+ +V+I V DVNDN PVF  P     L+  
Sbjct: 671  TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 728

Query: 699  DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756
            +    + V  ++A D DA  N  + Y L  GN  N F ++S    G I  A+ L+ +   
Sbjct: 729  EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 783

Query: 757  QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
             Y L V A+DG    R  T  + I V D + + PVF +S YTV V E+ P GT+I  + A
Sbjct: 784  YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843

Query: 814  NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867
             D D G N  ++Y I+ P  +  F + P +G +  +  LDYE     + + T  + A D 
Sbjct: 844  KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901

Query: 868  GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925
                     T+ +++ D ND  P F    Y+G +  DA   T I  V A D D    P  
Sbjct: 902  YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961

Query: 926  RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980
            R+ Y     DD         F +E  SG + T+  L+ E   ++ L  +A D G P  +S
Sbjct: 962  RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 1017

Query: 981  ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
            +S  +++ +L   +  P F ++E     V E    G++V  I A       N  I+Y IV
Sbjct: 1018 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1072

Query: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089
             G+    F ++ + G +     LD+E R  YVL VQA S  +V          + A V+I
Sbjct: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132

Query: 1090 LLVDQNDNPPV 1100
             + D+N++PPV
Sbjct: 1133 EIQDENNHPPV 1143



 Score =  226 bits (575), Expect = 3e-58
 Identities = 239/862 (27%), Positives = 379/862 (43%), Gaps = 109/862 (12%)

Query: 410  STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
            ST  VLDR+     + ++V+     +  G +     V I V D NDN P F  ++Y   V
Sbjct: 98   STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 156

Query: 469  PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSIL------SGNVAGQFYLHSLSGILD 517
             E   + T +         ATD D G N  I Y I       + N   +  L  L+G + 
Sbjct: 157  NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-MLTGNIV 215

Query: 518  VINPLDFEDVQKYSLSIKAQDGGRPPLIN----SSGVVSVQVLDVNDNEPIFVSSPFQAT 573
            +   L++ED  +Y + I+A D  R   +N    ++  ++V VLD +D  P+F+       
Sbjct: 216  LRKRLNYEDKTRYFVIIQAND--RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273

Query: 574  VLENVPLGY--------------PVV---HIQAVDAD------SGENARLHYRLVDTAST 610
              +  PL Y              P++    IQA+D D      S     L+  LV T   
Sbjct: 274  TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT--- 330

Query: 611  FLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSS 670
                       P   P F F +H  +  +++   ++R+  + +   ++A      P+ + 
Sbjct: 331  -----------PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF 378

Query: 671  TSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV-- 719
              + I +LD N+  P FT P+Y+  + E A VG+++         L + A D+D      
Sbjct: 379  AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438

Query: 720  ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLIN 778
                L   +  + F ++       +TL  P+D +++Q Y  ++TA DG + S    V I 
Sbjct: 439  PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQ 498

Query: 779  VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRI 837
            V DAN + P F    Y V V  D   G S+  L+A D D G N  ITY ++      F I
Sbjct: 499  VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 558

Query: 838  DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLW 894
            +  +G +     ++      Y LT+ A DN  P  +++   T+ I +L  N+ + P+F  
Sbjct: 559  NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 618

Query: 895  DFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR 954
              Y   I E       +L + ATDR+      + Y  + GD     F +  T+G++   +
Sbjct: 619  LMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGK 674

Query: 955  RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEEN 1011
             LDRE+   Y L   A D G P   S +  + + + D+NDNAP+F+      L +  EE 
Sbjct: 675  ALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732

Query: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
            N   + V +++A DPD G N Q+ Y +  G+  + F++   NG +   V+L+ EVR  Y 
Sbjct: 733  N---AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYE 786

Query: 1072 LVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCI 1127
            LVV AT     P  S  T+ I ++D +DN PV  +     + Y      + P G  I  I
Sbjct: 787  LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQI 841

Query: 1128 PAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIH 1185
             A D D+  +++Y            L P TGEL L R LD     EA    E S++  + 
Sbjct: 842  EAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVE 897

Query: 1186 SVTAFCTL-----RVTIITDDM 1202
            +   + T+      VT+I  DM
Sbjct: 898  AFDIYGTMPPGIATVTVIVKDM 919


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 128,405,531
Number of Sequences: 37866
Number of extensions: 6754658
Number of successful extensions: 45792
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 399
Number of HSP's successfully gapped in prelim test: 492
Number of HSP's that attempted gapping in prelim test: 24029
Number of HSP's gapped (non-prelim): 7788
length of query: 3014
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2894
effective length of database: 13,703,598
effective search space: 39658212612
effective search space used: 39658212612
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.