Guide to the Human Genome
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Search of human proteins with 72256200

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|72256200 B-cell CLL/lymphoma 9 [Homo sapiens]
         (1426 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|72256200 B-cell CLL/lymphoma 9 [Homo sapiens]                     2967   0.0  
gi|32698936 B-cell CLL/lymphoma 9-like [Homo sapiens]                 683   0.0  
gi|15890086 type IV collagen alpha 5 isoform 2 precursor [Homo s...   129   2e-29
gi|15890088 type IV collagen alpha 5 isoform 3 precursor [Homo s...   127   8e-29
gi|4502955 type IV collagen alpha 5 isoform 1 precursor [Homo sa...   126   1e-28
gi|148536825 alpha 1 type IV collagen preproprotein [Homo sapiens]    115   2e-25
gi|89142737 alpha 3 type IV collagen isoform 5 precursor [Homo s...   113   1e-24
gi|89142735 alpha 3 type IV collagen isoform 4 precursor [Homo s...   113   1e-24
gi|89142733 alpha 3 type IV collagen isoform 2 precursor [Homo s...   113   1e-24
gi|89142730 alpha 3 type IV collagen isoform 1 precursor [Homo s...   113   1e-24
gi|116256356 alpha 4 type IV collagen precursor [Homo sapiens]        112   2e-24
gi|32140760 collagen, type XXVII, alpha 1 [Homo sapiens]              112   2e-24
gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Ho...   112   3e-24
gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Ho...   112   3e-24
gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Ho...   112   3e-24
gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens]      112   3e-24
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom...   106   1e-22
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom...   105   4e-22
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]     105   4e-22
gi|110735435 collagen, type V, alpha 3 preproprotein [Homo sapiens]   103   9e-22
gi|32895368 alpha 1 type VIII collagen precursor [Homo sapiens]       102   2e-21
gi|17738302 alpha 1 type VIII collagen precursor [Homo sapiens]       102   2e-21
gi|148536823 type IV alpha 6 collagen isoform A precursor [Homo ...   101   4e-21
gi|16357503 type IV alpha 6 collagen isoform B precursor [Homo s...   101   4e-21
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]     101   6e-21
gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]               101   6e-21
gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]       99   4e-20
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    99   4e-20
gi|18105032 type X collagen alpha 1 precursor [Homo sapiens]           94   1e-18
gi|163965366 nascent polypeptide-associated complex alpha subuni...    91   8e-18

>gi|72256200 B-cell CLL/lymphoma 9 [Homo sapiens]
          Length = 1426

 Score = 2967 bits (7692), Expect = 0.0
 Identities = 1426/1426 (100%), Positives = 1426/1426 (100%)

Query: 1    MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQ 60
            MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQ
Sbjct: 1    MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQ 60

Query: 61   PSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDS 120
            PSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDS
Sbjct: 61   PSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDS 120

Query: 121  DIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVF 180
            DIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVF
Sbjct: 121  DIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVF 180

Query: 181  STEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPA 240
            STEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPA
Sbjct: 181  STEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPA 240

Query: 241  PANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPP 300
            PANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPP
Sbjct: 241  PANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPP 300

Query: 301  DGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRE 360
            DGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRE
Sbjct: 301  DGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRE 360

Query: 361  RSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGP 420
            RSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGP
Sbjct: 361  RSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGP 420

Query: 421  GPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFY 480
            GPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFY
Sbjct: 421  GPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFY 480

Query: 481  EEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINM 540
            EEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINM
Sbjct: 481  EEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINM 540

Query: 541  PHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIP 600
            PHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIP
Sbjct: 541  PHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIP 600

Query: 601  DGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNR 660
            DGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNR
Sbjct: 601  DGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNR 660

Query: 661  MIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDV 720
            MIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDV
Sbjct: 661  MIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDV 720

Query: 721  NLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMG 780
            NLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMG
Sbjct: 721  NLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMG 780

Query: 781  PRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRG 840
            PRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRG
Sbjct: 781  PRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRG 840

Query: 841  LGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPA 900
            LGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPA
Sbjct: 841  LGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPA 900

Query: 901  AAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPA 960
            AAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPA
Sbjct: 901  AAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPA 960

Query: 961  MLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPS 1020
            MLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPS
Sbjct: 961  MLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPS 1020

Query: 1021 STPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPM 1080
            STPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPM
Sbjct: 1021 STPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPM 1080

Query: 1081 GMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQG 1140
            GMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQG
Sbjct: 1081 GMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQG 1140

Query: 1141 FPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGG 1200
            FPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGG
Sbjct: 1141 FPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGG 1200

Query: 1201 PDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGR 1260
            PDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGR
Sbjct: 1201 PDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGR 1260

Query: 1261 KQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPA 1320
            KQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPA
Sbjct: 1261 KQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPA 1320

Query: 1321 FLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGM 1380
            FLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGM
Sbjct: 1321 FLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGM 1380

Query: 1381 MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF 1426
            MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
Sbjct: 1381 MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF 1426


>gi|32698936 B-cell CLL/lymphoma 9-like [Homo sapiens]
          Length = 1499

 Score =  683 bits (1763), Expect = 0.0
 Identities = 570/1591 (35%), Positives = 758/1591 (47%), Gaps = 272/1591 (17%)

Query: 5    NPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPS-- 62
            +P+ R +P G+   SP+        PP    P      ++K +N GK G   +QSQ    
Sbjct: 12   HPRRREAP-GSPPLSPRGHC-----PPAPAKPM---HPENKLTNHGKTGNGGAQSQHQNV 62

Query: 63   ----PCDSKS-----GGHTPKALPGPGGSMGLKNGAG-----NGAKGKGKRERSISADSF 108
                 C+  S     G H  KA      +  LKN        +  KGK KR+RS+S DS 
Sbjct: 63   NQGPTCNVGSKGVGAGNHGAKANQISPSNSSLKNPQAGVPPFSSLKGKVKRDRSVSVDSG 122

Query: 109  DQRDPGTPNDDSDIKE----------------------CNSADHIKSQDSQHTPHSMTPS 146
            +QR+ GTP+ DS+ KE                      C+  D  +        H+    
Sbjct: 123  EQREAGTPSLDSEAKEVAPRSKRRCVLERKQPYSGDEWCSGPDSEEDDKPIGATHNC--- 179

Query: 147  NATAPRSSTPSHGQTTATE--------------PTPAQ----------------KTPAKV 176
            N   P  + P  G    T+              P P                  K P++ 
Sbjct: 180  NVADPAMAAPQLGPGQTTQLPLSESSVPGAPHGPPPGLRPDAPGGGGGGGGVPGKPPSQF 239

Query: 177  VYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQ 236
            VYVF+T +AN AAEAVL+G+ ++I+++H QN+   K +++              PK  P 
Sbjct: 240  VYVFTTHLANTAAEAVLQGRADSILAYHQQNVPRAKLDQA--------------PKVPPT 285

Query: 237  QPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIP-SVGSPASS 295
              P P +     +  ++  P PP P PAP  A P  P +         L P SVG  A+S
Sbjct: 286  PEPLPLSTPSAGTPQSQPPPLPPPPPPAPGSAPPALPPEGPPEDSSQDLAPNSVG--AAS 343

Query: 296  TPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENP----DGL 351
            T     GT PN+     A  P+  G + SSA    P P  +     P  G+      +GL
Sbjct: 344  TGGGTGGTHPNTPTATTANNPLPPGGDPSSA----PGPALLGEAAAPGNGQRSLVGSEGL 399

Query: 352  SQEQLEHRERSLQTLRDIQRMLFP--DEKEFT-----GAQSGGP--------QQNPGVLD 396
            S+EQLEHRERSLQTLRDI+R+L    + + F      GA  GGP        QQ P    
Sbjct: 400  SKEQLEHRERSLQTLRDIERLLLRSGETEPFLKGPPGGAGEGGPPAQAPPPPQQPPTAPP 459

Query: 397  GPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVP-FSPDEMVPPSMNSQSG 455
               KK E P+Q+M++Q+QSLG             GP    +VP   P   +   MN    
Sbjct: 460  SGLKKYEEPLQSMISQTQSLG-------------GPPLEHEVPGHPPGGDMGQQMNMMIQ 506

Query: 456  TIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCS-LQDMMVHQHGPRGV-VRG 513
             +G D L   TPEQ+AW KLQ+E+YEEKRRK+EQ+ +     LQDMM    G  G+ VRG
Sbjct: 507  RLGQDSL---TPEQVAWRKLQEEYYEEKRRKEEQIGLHGSRPLQDMM----GMGGMMVRG 559

Query: 514  PPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPN--MPGSQM-RLPGFAGMIN 570
            PPPPY   P + W PG        +++   +  RG  P P    PG+Q+ R+PGF GM +
Sbjct: 560  PPPPYHSKPGDQWPPGMGAQLRGPMDVQDPMQLRGGPPFPGPRFPGNQIQRVPGFGGMQS 619

Query: 571  SEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIF-SGPGRGERFPNPQGLSE 629
              ME P   N   RP   G+ W +D+P +    NF      +  G G  ERF  P+ + E
Sbjct: 620  MPMEVPM--NAMQRPVRPGMGWTEDLPPMGGPSNFAQNTMPYPGGQGEAERFMTPR-VRE 676

Query: 630  EMFQQQLAEKQ-LGL--PPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEG-- 684
            E+ + QL EK+ +G+  P GMA  G+  SMEM RM+  + R M+P    +FP     G  
Sbjct: 677  ELLRHQLLEKRSMGMQRPLGMAGSGMGQSMEMERMMQ-AHRQMDPA---MFPGQMAGGEG 732

Query: 685  ----PLSPSRGDFPKGIPPQMGPG--RELEFGMVPSG--MKGDVNLNVNMGSNSQMIPQK 736
                P+    G     + P MG    RE++  M P    M  +VN+N+NM  N QM PQ+
Sbjct: 733  LAGTPMGMEFGGGRGLLSPPMGQSGLREVDPPMGPGNLNMNMNVNMNMNMNLNVQMTPQQ 792

Query: 737  --------------MREAGAGPEEMLKLRPGGSD--MLPAQQKMVPLPFGEHPQQEYGMG 780
                          M   G  PEEM ++R   S   M   Q+ ++P  F    QQ +  G
Sbjct: 793  QMLMSQKMRGPGDLMGPQGLSPEEMARVRAQNSSGVMGGPQKMLMPSQFPNQGQQGFSGG 852

Query: 781  PRPFLPMSQGPGSNSGLRNLREPIGPDQRT-------NSRLSHMPPLPLNPSSNPT-SLN 832
              P+  MSQ  G      N ++   PDQ +        +RLSHMP   L P+SNP  +++
Sbjct: 853  QGPYQAMSQDMG------NTQDMFSPDQSSMPMSNVGTTRLSHMP---LPPASNPPGTVH 903

Query: 833  TAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQL 892
            +AP   RGLGR+P D++++ +Q+ SPG+  LKSPT+ QV SP++ SPS NLKSPQTPSQ+
Sbjct: 904  SAP--NRGLGRRPSDLTISINQMGSPGMGHLKSPTLSQVHSPLVTSPSANLKSPQTPSQM 961

Query: 893  AGMLAGPAA--AASIKSPPVLGSAAA------SPVHLKSPSLPAPSPGWTSSPKPPLQSP 944
              +   P+A     +KSP VLGS+ +      SP  LKSPS+  PSPGW +SPK  + SP
Sbjct: 962  VPL---PSANPPGPLKSPQVLGSSLSVRSPTGSPSRLKSPSMAVPSPGWVASPKTAMPSP 1018

Query: 945  GIPPNHKAPLTMASPAMLGNVESGGPPPP----TASQPASVNIPGSLPSSTPYTMPPEPT 1000
            G+  N + PL M S   L N+E G  PP     ++S P +    G +  S P+T  P+PT
Sbjct: 1019 GVSQNKQPPLNMNSSTTLSNMEQGTLPPSGPRSSSSAPPANPPSGLMNPSLPFTSSPDPT 1078

Query: 1001 LSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINT 1060
             SQNPLS+MM++MSK+AMPSSTPLYH+AIKT+A+SDD+  P R P LP      G G   
Sbjct: 1079 PSQNPLSLMMTQMSKYAMPSSTPLYHNAIKTIATSDDELLPDR-PLLPPPPPPQGSGPGI 1137

Query: 1061 QNPRISGPNPVVPMPTLSPMGMT----QPLSHS---NQMPSPNAVGPNIPPHGVPMGPGL 1113
             N + S  + +      SPMGM     QPLSH      +PSP  +G NIP H    G G 
Sbjct: 1138 SNSQPSQMH-LNSAAAQSPMGMNLPGQQPLSHEPPPAMLPSPTPLGSNIPLHPNAQGTGG 1196

Query: 1114 MSHNPIM----GHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQG---SFP 1166
               N +M    G  S   P  P         FPP    P     P  G  GG G    +P
Sbjct: 1197 PPQNSMMMAPGGPDSLNAPCGPVPSSSQMMPFPPRLQQPHGAMAPTGGGGGGPGLQQHYP 1256

Query: 1167 GGMGFPGEG-PLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIR 1225
             GM  P E  P   P  +P           G  G      VL   + SV  DP+L EVIR
Sbjct: 1257 SGMALPPEDLPNQPPGPMPPQQHLMGKAMAGRMGDAYPPGVL-PGVASVLNDPELSEVIR 1315

Query: 1226 PGATGIPEFDLSRIIPSEKPSQTLQYFPRGE-VPGRKQPQGPGPGFSHMQGMMGEQAPRM 1284
            P  TGIPEFDLSRIIPSEKPS TLQYFP+ E  P + QP  P     ++Q MM EQ P  
Sbjct: 1316 PTPTGIPEFDLSRIIPSEKPSSTLQYFPKSENQPPKAQP--PNLHLMNLQNMMAEQTPSR 1373

Query: 1285 GLALPGMGGPGPVGTPDIPLGTAPSM--PGHNPM--RPPAFLQQGMM--GPHHRMMSPAQ 1338
               LPG  G        +  G   SM  PG   +  R     QQGM+  G H  +MSP Q
Sbjct: 1374 PPNLPGQQG--------VQRGLNMSMCHPGQMSLLGRTGVPPQQGMVPHGLHQGVMSPPQ 1425

Query: 1339 STMPGQPTLMSNPAAAVGMIPGKDRGPAG-LYTHPGPVGSPGMMMSMQGMMG--PQQNIM 1395
              M  Q  ++            K RG  G +Y+ P     P M+     +MG  PQQN+M
Sbjct: 1426 GLMTQQNFMLM-----------KQRGVGGEVYSQP-----PHMLSPQGSLMGPPPQQNLM 1469

Query: 1396 IPPQMRPRGMAADVGMGGFSQGPGNPGNMMF 1426
            +   +R R ++ D  M G+   PG   N+ F
Sbjct: 1470 VSHPLRQRSVSLDSQM-GYLPAPGGMANLPF 1499


>gi|15890086 type IV collagen alpha 5 isoform 2 precursor [Homo
            sapiens]
          Length = 1691

 Score =  129 bits (324), Expect = 2e-29
 Identities = 329/1225 (26%), Positives = 411/1225 (33%), Gaps = 261/1225 (21%)

Query: 256  PTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVT 315
            P PP  A    P  P  P +R   G E       G P  S P PP   G    P      
Sbjct: 385  PGPPGAAVMGPPGPPGFPGERGQKGDE-------GPPGISIPGPPGLDGQPGAPGLPG-P 436

Query: 316  PVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFP 375
            P   G +   +D    P PP   G P        GL  EQ    ++       I      
Sbjct: 437  PGPAGPHIPPSDEICEPGPPGPPGSP-----GDKGLQGEQGVKGDKGDTCFNCI------ 485

Query: 376  DEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGH 435
                  G    GP   PG+   P     GP  ++    Q   KG    T      GP+G 
Sbjct: 486  ------GTGISGPPGQPGLPGLP-----GPPGSLGFPGQKGEKGQAGAT------GPKGL 528

Query: 436  RDVPFSP-------------DEMVPPSMNSQSGTIGPDHLDHM-----TPEQIAWLKLQQ 477
              +P +P             D +  P M    G +G      +     TP Q     L  
Sbjct: 529  PGIPGAPGAPGFPGSKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGLPGLPG 588

Query: 478  EFYEEK--RRKQEQVVVQQCSLQDMM--VHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEP 533
               E      K E+       L  +   +   GP G   GPP P      +G A    +P
Sbjct: 589  PKGEPGGITFKGERGPPGNPGLPGLPGNIGPMGPPGF--GPPGPVGEKGIQGVAGNPGQP 646

Query: 534  FSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWP 593
               GI  P   P + +   P  PG    LPG  G  + ++  P  P    +PGL G+   
Sbjct: 647  ---GIPGPKGDPGQTIT-QPGKPG----LPGNPGR-DGDVGLPGDPGLPGQPGLPGIPGS 697

Query: 594  DDVPKIPD-GRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGI 652
               P IP  G   PPG   F G       P P G               G P  + +EG 
Sbjct: 698  KGEPGIPGIGLPGPPGPKGFPG------IPGPPGAP-------------GTPGRIGLEGP 738

Query: 653  R--PSMEMNRMIPGSQRHMEPGNNPIFPRIP-VEGPLSPSRGDFPKGIPPQMGPGRELEF 709
               P     +  PG      PG     P +P  +G L P +GD  +G P   GP      
Sbjct: 739  PGPPGFPGPKGEPGFALPGPPGP----PGLPGFKGALGP-KGD--RGFPGPPGPPGRTGL 791

Query: 710  GMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPF 769
              +P G KGDV      G N Q  P        GP  +    PG     P     +P P 
Sbjct: 792  DGLP-GPKGDV------GPNGQPGPM-------GPPGL----PGIGVQGPPGPPGIPGPI 833

Query: 770  GEH-----PQQEYGMGPRPFLPMSQGPGSNS--GLRNLREPIGPDQRTNSRLSHMPPLPL 822
            G+      P ++   GP P L +   PG     G+     PIGP           P LP 
Sbjct: 834  GQPGLHGIPGEKGDPGP-PGLDVPGPPGERGSPGIPGAPGPIGPPGS--------PGLPG 884

Query: 823  NPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGN 882
               ++            G    P  + + G      G+  LK     Q Q P L  P+G 
Sbjct: 885  KAGASGFPGTKGEMGMMGPPGPPGPLGIPGRS----GVPGLKGDDGLQGQ-PGLPGPTGE 939

Query: 883  LKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQ 942
              S   P      L GP        P +LGS          P LP   PG  S PK    
Sbjct: 940  KGSKGEPG-----LPGPPGPMD---PNLLGSKGEKG----EPGLPG-IPG-VSGPKGYQG 985

Query: 943  SPGIPPNHKAPLTMASPAMLGNVESGGPPPPTAS-----QPASVNIPGSLPSSTPYTMPP 997
             PG P           P + G     GPP P  +     QP  +  PG L  +      P
Sbjct: 986  LPGDP---------GQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPG-LKGTIGDMGFP 1035

Query: 998  EPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARS----PNLPSMNNM 1053
             P   + P             PS  P    +        D   P  S    P LP     
Sbjct: 1036 GPQGVEGPPG-----------PSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGE 1084

Query: 1054 PGMGINTQNPRISGP--NPVVPMPTLSPMGMTQPLSHSNQMPS-PNAVGPNIPP--HGVP 1108
            PG+     NP I G   +P +P    +P    QP      +P  P   GP  P    G P
Sbjct: 1085 PGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQP-----GLPGFPGTPGPPGPKGISGPP 1139

Query: 1109 MGPGLMSHNPIMGHGSQEPPMVPQGRMGFP--QGFPPVQSPPQQVPFPHNGPSGGQGSFP 1166
              PGL      +G G       P G  G P   G P              GP+G +G  P
Sbjct: 1140 GNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIP--------------GPAGQKGE-P 1184

Query: 1167 GGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRP 1226
            G  GF   GP G P  L     D  L  PG PG P         +P    +P       P
Sbjct: 1185 GQPGFGNPGPPGLP-GLSGQKGDGGL--PGIPGNP--------GLPGPKGEPGFHGF--P 1231

Query: 1227 GATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGP--GPGFSHMQGMMGEQAPRM 1284
            G  G P        P   P   L+  P+G  PG   PQGP   PG +  QG+ G + P  
Sbjct: 1232 GVQGPPG-------PPGSPGPALE-GPKGN-PG---PQGPPGRPGPTGFQGLPGPEGPP- 1278

Query: 1285 GLALPGMGG-PGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPG 1343
               LPG GG  G  G P  P    P +PG    + P  L QG  G       P  + M G
Sbjct: 1279 --GLPGNGGIKGEKGNPGQP--GLPGLPGLKGDQGPPGL-QGNPG------RPGLNGMKG 1327

Query: 1344 QPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMM--MSMQGMMGPQ-QNIMIPPQM 1400
             P L   P       PG  +GP+G+    GP G PG++      G+ GP  Q+I+I    
Sbjct: 1328 DPGLPGVPG-----FPGM-KGPSGVPGSAGPEGEPGLIGPPGPPGLPGPSGQSIIIKGDA 1381

Query: 1401 RPRGMAADVGMGGF--SQGP-GNPG 1422
             P G+    G+ G    QGP G PG
Sbjct: 1382 GPPGIPGQPGLKGLPGPQGPQGLPG 1406



 Score =  115 bits (288), Expect = 3e-25
 Identities = 261/987 (26%), Positives = 330/987 (33%), Gaps = 208/987 (21%)

Query: 506  GPRGVVRGPP--PPYQMTPSEGWAPGGTEPFSDGINMPHSLP-------PRGMAPHPNMP 556
            GP+G+ RGPP  P +  TP     PG      DG   P  +P        RG    P  P
Sbjct: 87   GPKGI-RGPPGLPGFPGTPGLPGMPG-----HDGAPGPQGIPGCNGTKGERGFPGSPGFP 140

Query: 557  GSQ-----MRLPGFAG----MINSEMEGPNV-PNPASRPGLSGVSWPDDVPKIPDGRNFP 606
            G Q       +PG  G    +I S + GP   P     PG+ G+  P  +P    G   P
Sbjct: 141  GLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPGIQGLPGPTGIP----GPIGP 196

Query: 607  PGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEK-QLGL-----PPGMAMEGIRP-SMEMN 659
            PG     GP      P P+G     FQ    EK + GL     PPG   E  RP  +E  
Sbjct: 197  PGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQ 256

Query: 660  RMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDF----PKGIPPQMG-PGRELEFGM--V 712
            +   G      P   P      + GP  P  G+      +G P + G PG++ E G   +
Sbjct: 257  KGDQGLPGDRGPPGPP-----GIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGI 311

Query: 713  PSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPG-----------GSDMLPAQ 761
            P G+ GD       G + +   QK      GP  ++  RPG           G   LP +
Sbjct: 312  P-GLPGDPGYPGEPGRDGEK-GQKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGE 369

Query: 762  QKMVPLPFGEHPQQEYG------MGPR--PFLPMSQGPGSNSGLRNLREPIGP--DQRTN 811
            +     P  + P    G      MGP   P  P  +G   + G   +  P  P  D +  
Sbjct: 370  KGERGFPGIQGPPGLPGPPGAAVMGPPGPPGFPGERGQKGDEGPPGISIPGPPGLDGQPG 429

Query: 812  SRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQV 871
            +     PP P  P   P+      P   G    P D  + G Q    G+   K  T    
Sbjct: 430  APGLPGPPGPAGPHIPPSD-EICEPGPPGPPGSPGDKGLQGEQ----GVKGDKGDTCFNC 484

Query: 872  QSPMLGSPSGNLKSPQTPSQLAGM-------LAGPAAAASIKSPPVLGSAAASPVHLKSP 924
                +  P G    P  P     +         G A A   K  P +  A  +P    S 
Sbjct: 485  IGTGISGPPGQPGLPGLPGPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSK 544

Query: 925  SLPAPS---PGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASV 981
              P      PG     K  L SPG P           P + G     G P      P   
Sbjct: 545  GEPGDILTFPGMKGD-KGELGSPGAP---------GLPGLPGTPGQDGLP----GLPGPK 590

Query: 982  NIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPP 1041
              PG +        P  P L   P +I       F  P   P+    I+ VA +      
Sbjct: 591  GEPGGITFKGERGPPGNPGLPGLPGNIGPMGPPGFGPPG--PVGEKGIQGVAGNPGQ--- 645

Query: 1042 ARSPNLPSMNNMPGMGINTQN-PRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVG- 1099
               P +P     PG  I     P + G NP                     +  P   G 
Sbjct: 646  ---PGIPGPKGDPGQTITQPGKPGLPG-NP----------------GRDGDVGLPGDPGL 685

Query: 1100 PNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPS 1159
            P  P  G+P  PG      I G G   PP         P+GFP +  PP     P  G  
Sbjct: 686  PGQP--GLPGIPGSKGEPGIPGIGLPGPPG--------PKGFPGIPGPPGAPGTP--GRI 733

Query: 1160 GGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPD 1219
            G +G  PG  GFPG  P G P         A    PG PG P     LG      F  P 
Sbjct: 734  GLEGP-PGPPGFPG--PKGEPGF-------ALPGPPGPPGLPGFKGALGPKGDRGFPGPP 783

Query: 1220 LQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGE 1279
                  PG TG+                         +PG K   GP           G+
Sbjct: 784  GP----PGRTGLDG-----------------------LPGPKGDVGPN----------GQ 806

Query: 1280 QAPRMGLALPGMGGPGPVGTPDI--PLGT--APSMPGHNPMRPPAFLQQGMMGPHHRMMS 1335
              P     LPG+G  GP G P I  P+G      +PG      P  L   + GP     S
Sbjct: 807  PGPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLD--VPGPPGERGS 864

Query: 1336 PAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIM 1395
            P    +PG P  +  P +    +PGK    AG    PG  G  GMM    G  GP   + 
Sbjct: 865  PG---IPGAPGPIGPPGSP--GLPGK----AGASGFPGTKGEMGMM----GPPGPPGPLG 911

Query: 1396 IPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            IP +    G+  D G+ G    PG PG
Sbjct: 912  IPGRSGVPGLKGDDGLQG---QPGLPG 935



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 135/476 (28%), Positives = 174/476 (36%), Gaps = 112/476 (23%)

Query: 1041 PARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGP 1100
            P   P +P M   PG  I +  P   G NP  P     P G+ Q L     +P P  +GP
Sbjct: 145  PPGPPGIPGMKGEPGSIIMSSLPGPKG-NPGYP----GPPGI-QGLPGPTGIPGP--IGP 196

Query: 1101 NIPPH--GVPMGPGLMSHNPIMG------------HGSQEPPMVP--------------- 1131
              PP   G P  PGL      MG             G Q PP  P               
Sbjct: 197  PGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQ 256

Query: 1132 QGRMGFP-----QGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPG-EGPLGRPSNLPQ 1185
            +G  G P      G P ++ PP   P    G  G QG  PG  G PG +G  G+P  +P 
Sbjct: 257  KGDQGLPGDRGPPGPPGIRGPPGP-PGGEKGEKGEQGE-PGKRGKPGKDGENGQPG-IPG 313

Query: 1186 SSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRI----IP 1241
               D     PG PG P      G    +    P    + RPG TGI   +   I    +P
Sbjct: 314  LPGD-----PGYPGEPGRDGEKGQKGDTGPPGPPGLVIPRPG-TGITIGEKGNIGLPGLP 367

Query: 1242 SEKPSQTLQYFPRGE-VPGRKQPQG------PGP-GFSHMQGMMGEQAPRMGLALPGMGG 1293
             EK  +    FP  +  PG   P G      PGP GF   +G  G++ P  G+++PG  G
Sbjct: 368  GEKGERG---FPGIQGPPGLPGPPGAAVMGPPGPPGFPGERGQKGDEGPP-GISIPGPPG 423

Query: 1294 ----PGPVGTPDIPLGTAPSMPGHN------PMRPPAFL-------QQGMMGPH----HR 1332
                PG  G P  P    P +P  +      P  PP          +QG+ G        
Sbjct: 424  LDGQPGAPGLPGPPGPAGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFN 483

Query: 1333 MMSPAQSTMPGQPTL--MSNPAAAVGMIPGKD--------RGPAGLYT---------HPG 1373
             +    S  PGQP L  +  P  ++G  PG+          GP GL            PG
Sbjct: 484  CIGTGISGPPGQPGLPGLPGPPGSLGF-PGQKGEKGQAGATGPKGLPGIPGAPGAPGFPG 542

Query: 1374 PVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGP---GNPGNMMF 1426
              G PG +++  GM G +  +  P      G+    G  G    P   G PG + F
Sbjct: 543  SKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGLPGLPGPKGEPGGITF 598



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 100/329 (30%), Positives = 119/329 (36%), Gaps = 73/329 (22%)

Query: 1111 PGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMG 1170
            PGL  H  + G    E P  P+G+ G   G P    PP   P    GP G  G FPG  G
Sbjct: 53   PGLEGHPGLPGFPGPEGPPGPRGQKG-DDGIP---GPPG--PKGIRGPPGLPG-FPGTPG 105

Query: 1171 FPG-EGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGAT 1229
             PG  G  G P        +    + G PG P                P LQ    PG  
Sbjct: 106  LPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGF--------------PGLQGP--PGPP 149

Query: 1230 GIPEF--DLSRIIPSEKPSQTLQYFPRGEVPGRKQPQG----PGPGFSHMQGMMGEQAPR 1283
            GIP    +   II S  P       P+G  PG   P G    PGP  + + G +G   P 
Sbjct: 150  GIPGMKGEPGSIIMSSLPG------PKGN-PGYPGPPGIQGLPGP--TGIPGPIGPPGP- 199

Query: 1284 MGLALPG-MGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFL-QQGMMGPHHRMMSPAQSTM 1341
                 PG MG PGP G P  P G      G N   P     +QG+ GP            
Sbjct: 200  -----PGLMGPPGPPGLPG-PKGNM----GLNFQGPKGEKGEQGLQGP------------ 237

Query: 1342 PGQPTLMSNPAAAVGM--------IPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQN 1393
            PG P  +S     + +        +PG DRGP G     GP G PG     +G  G    
Sbjct: 238  PGPPGQISEQKRPIDVEFQKGDQGLPG-DRGPPGPPGIRGPPGPPGGEKGEKGEQGEPGK 296

Query: 1394 IMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
               P +    G     G+ G    PG PG
Sbjct: 297  RGKPGKDGENGQPGIPGLPGDPGYPGEPG 325



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 167/707 (23%), Positives = 233/707 (32%), Gaps = 156/707 (22%)

Query: 235  PQQPPAPANQDQNSSQNTRLQPTPP-IPAPAPKPAAPPRPLDRESPGVENKLIP------ 287
            P   P P           +  P PP IP P  +P     P ++  PG     +P      
Sbjct: 803  PNGQPGPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLDVPGPPGER 862

Query: 288  -SVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPP--PVSSGEPPTL 344
             S G P +  P+ P G+         +  P ++G       P  P P   P  SG P   
Sbjct: 863  GSPGIPGAPGPIGPPGSPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLK 922

Query: 345  GENPDGLSQEQL---EHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGV-----LD 396
            G+  DGL  +        E+  +    +     P +    G++  G +  PG+     + 
Sbjct: 923  GD--DGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSK--GEKGEPGLPGIPGVS 978

Query: 397  GP---QKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQ 453
            GP   Q  P  P Q  ++    L   PGP        GP+G+  +P  P  + PP +   
Sbjct: 979  GPKGYQGLPGDPGQPGLSGQPGL---PGPP-------GPKGNPGLPGQPGLIGPPGL--- 1025

Query: 454  SGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRG 513
             GTIG    D   P                                      GP+G V G
Sbjct: 1026 KGTIG----DMGFP--------------------------------------GPQG-VEG 1042

Query: 514  PPPPYQMTPSEGWAPG-------GTEPFSDGINMPHSLPPRGMAPHPNMPGS-------- 558
            PP P    P +  +PG         +P    I +P    P+G    P  PG+        
Sbjct: 1043 PPGP-SGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVG 1101

Query: 559  QMRLPGFAGMINSEMEG--PNVPNPASRPGLSGVSWPDDVPKIP-----------DGRNF 605
               LPG  G   ++ +   P  P     PG  G+S P   P +P            G+  
Sbjct: 1102 DPGLPGLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPG 1161

Query: 606  PPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEK-QLGLP--PGMAMEGIRPSMEMNRMI 662
            PPG+    G    +  P P G   E  Q         GLP   G   +G  P +  N  +
Sbjct: 1162 PPGE---KGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGL 1218

Query: 663  PGSQRHMEPGNNPIFPRIP-VEGPLSPSRG-----DFPKGIP-PQMGPGRELEFGMV--- 712
            PG      P   P F   P V+GP  P        + PKG P PQ  PGR    G     
Sbjct: 1219 PG------PKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGPTGFQGLP 1272

Query: 713  ----PSGMKGDVNLNVNMGSNSQM----IPQKMREAGAGPEEMLKLRPGGSDM------- 757
                P G+ G+  +    G+  Q     +P    + G    +    RPG + M       
Sbjct: 1273 GPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLP 1332

Query: 758  ----LPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSR 813
                 P  +    +P    P+ E G+   P  P   GP   S +  ++   GP       
Sbjct: 1333 GVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPGPSGQSII--IKGDAGPPGIPGQP 1390

Query: 814  LSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGI 860
                 P P  P   P    T PP   G    P     AG +   PG+
Sbjct: 1391 GLKGLPGPQGPQGLPGP--TGPPGDPGRNGLP-GFDGAGGRKGDPGL 1434



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 197/811 (24%), Positives = 258/811 (31%), Gaps = 135/811 (16%)

Query: 231  PKPLPQQPPAPANQDQNSSQNTRLQPTPP-IPAPAPKP--AAPPRPLDRESPGVENKLIP 287
            PK  P  P  P              P PP  P P  +P  A P  P     PG +  L P
Sbjct: 714  PKGFPGIPGPPGAPGTPGRIGLEGPPGPPGFPGPKGEPGFALPGPPGPPGLPGFKGALGP 773

Query: 288  SVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGEN 347
                     P PP  TG +  P  +       G N        P  P +    PP     
Sbjct: 774  KGDRGFPGPPGPPGRTGLDGLPGPKG----DVGPNGQPGPMGPPGLPGIGVQGPPGPPGI 829

Query: 348  PDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQS------GGPQQNPGVLDGPQKK 401
            P  + Q  L                  P EK   G          G + +PG+   P   
Sbjct: 830  PGPIGQPGLHG---------------IPGEKGDPGPPGLDVPGPPGERGSPGIPGAP--G 872

Query: 402  PEGPIQAMMAQSQSLGKG-PGPRTDVG--APFGPQGHRDVPFSPDEMVPPSMNSQSGTIG 458
            P GP  +     ++   G PG + ++G   P GP G   +   P     P +    G  G
Sbjct: 873  PIGPPGSPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGI---PGRSGVPGLKGDDGLQG 929

Query: 459  PDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQD-MMVHQHGPRGVVRGPPPP 517
               L   T               EK  K E  +       D  ++   G +G    P  P
Sbjct: 930  QPGLPGPT--------------GEKGSKGEPGLPGPPGPMDPNLLGSKGEKGEPGLPGIP 975

Query: 518  YQMTPSEGWAPGGTEPFSDGINMPHSLP-PRGMAPHPNMPGSQMRL--PGFAGMINSEME 574
                P +G+     +P   G++    LP P G   +P +PG    +  PG  G I  +M 
Sbjct: 976  GVSGP-KGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGLKGTI-GDMG 1033

Query: 575  GPNVPNPASRPGLSGVSWPDDVPKIP--DGRNFPPGQGIFSGPG----RGE----RFPNP 624
             P        PG SGV      P +P   G    PG      PG    +GE     +P  
Sbjct: 1034 FPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGN 1093

Query: 625  QGLSEEMFQQQLAEKQLGLP--PGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPV 682
             G+   +    L     GLP  PG   +   P        PG +    P  NP  P  P 
Sbjct: 1094 PGIKGSVGDPGLP----GLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEP- 1148

Query: 683  EGPLSPSRGDFPKGIPPQMG-PGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAG 741
             GP+         G P + G PG++   G  P+G KG+             +P    + G
Sbjct: 1149 -GPVGGGGHPGQPGPPGEKGKPGQDGIPG--PAGQKGEPGQPGFGNPGPPGLPGLSGQKG 1205

Query: 742  AGPEEMLKLRPG--------GSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGS 793
             G    +   PG        G    P  Q     P    P  E   GP+   P  QGP  
Sbjct: 1206 DGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALE---GPKG-NPGPQGPPG 1261

Query: 794  N---SGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISV 850
                +G + L  P GP           P LP N        N   P   GL     D   
Sbjct: 1262 RPGPTGFQGLPGPEGP-----------PGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGP 1310

Query: 851  AGSQVH--SPGINPLK-SPTMHQVQS-PMLGSPSG-----------NLKSPQTPSQLAG- 894
             G Q +   PG+N +K  P +  V   P +  PSG            L  P  P  L G 
Sbjct: 1311 PGLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPGP 1370

Query: 895  -----MLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPN 949
                 ++ G A    I   P L         L  P  P   PG T  P  P ++ G+P  
Sbjct: 1371 SGQSIIIKGDAGPPGIPGQPGLKG-------LPGPQGPQGLPGPTGPPGDPGRN-GLPGF 1422

Query: 950  HKAPLTMASPAMLGNVES---GGPPPPTASQ 977
              A      P + G   +    GPP P   Q
Sbjct: 1423 DGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQ 1453



 Score = 37.7 bits (86), Expect = 0.080
 Identities = 31/92 (33%), Positives = 38/92 (41%), Gaps = 16/92 (17%)

Query: 1343 GQPTLMSNPAAAVGMIPGK------------DRGPAGLYTHPGPVGSPGMMMSMQGMMGP 1390
            GQP   +  AA  G  PG             +RG  GL  HPG  G PG      G  G 
Sbjct: 21   GQP---AEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPG-PEGPPGPRGQ 76

Query: 1391 QQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            + +  IP    P+G+    G+ GF   PG PG
Sbjct: 77   KGDDGIPGPPGPKGIRGPPGLPGFPGTPGLPG 108



 Score = 33.5 bits (75), Expect = 1.5
 Identities = 29/98 (29%), Positives = 36/98 (36%), Gaps = 16/98 (16%)

Query: 36  PSGNPQLDSKFSNQGKQG--GSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGA 93
           P GNP        QG  G  G      P       G   P  LPGP G+MGL      G 
Sbjct: 169 PKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGE 228

Query: 94  KGK-------------GKRERSISADSFDQRDPGTPND 118
           KG+              +++R I  + F + D G P D
Sbjct: 229 KGEQGLQGPPGPPGQISEQKRPIDVE-FQKGDQGLPGD 265


>gi|15890088 type IV collagen alpha 5 isoform 3 precursor [Homo
            sapiens]
          Length = 1688

 Score =  127 bits (319), Expect = 8e-29
 Identities = 327/1245 (26%), Positives = 408/1245 (32%), Gaps = 250/1245 (20%)

Query: 256  PTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVT 315
            P PP  A    P  P  P +R   G E       G P  S P PP   G    P      
Sbjct: 385  PGPPGAAVMGPPGPPGFPGERGQKGDE-------GPPGISIPGPPGLDGQPGAPGLPG-P 436

Query: 316  PVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFP 375
            P   G +   +D    P PP   G P        GL  EQ    ++       I      
Sbjct: 437  PGPAGPHIPPSDEICEPGPPGPPGSP-----GDKGLQGEQGVKGDKGDTCFNCI------ 485

Query: 376  DEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGH 435
                  G    GP   PG+   P     GP  ++    Q   KG    T      GP+G 
Sbjct: 486  ------GTGISGPPGQPGLPGLP-----GPPGSLGFPGQKGEKGQAGAT------GPKGL 528

Query: 436  RDVPFSP-------------DEMVPPSMNSQSGTIGPDHLDHM-----TPEQIAWLKLQQ 477
              +P +P             D +  P M    G +G      +     TP Q     L  
Sbjct: 529  PGIPGAPGAPGFPGSKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGLPGLPG 588

Query: 478  EFYEEK--RRKQEQVVVQQCSLQDMM--VHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEP 533
               E      K E+       L  +   +   GP G   GPP P      +G A    +P
Sbjct: 589  PKGEPGGITFKGERGPPGNPGLPGLPGNIGPMGPPGF--GPPGPVGEKGIQGVAGNPGQP 646

Query: 534  FSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWP 593
               GI  P   P + +   P  PG    LPG  G  + ++  P  P    +PGL G+   
Sbjct: 647  ---GIPGPKGDPGQTIT-QPGKPG----LPGNPGR-DGDVGLPGDPGLPGQPGLPGIPGS 697

Query: 594  DDVPKIPD-GRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGI 652
               P IP  G   PPG   F G       P P G               G P  + +EG 
Sbjct: 698  KGEPGIPGIGLPGPPGPKGFPG------IPGPPGAP-------------GTPGRIGLEGP 738

Query: 653  R--PSMEMNRMIPGSQRHMEPGNNPIFPRIP-VEGPLSPSRGDFPKGIPPQMGPGRELEF 709
               P     +  PG      PG     P +P  +G L P +GD  +G P   GP      
Sbjct: 739  PGPPGFPGPKGEPGFALPGPPGP----PGLPGFKGALGP-KGD--RGFPGPPGPPGRTGL 791

Query: 710  GMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPF 769
              +P G KGDV      G N Q  P        GP  +    PG     P     +P P 
Sbjct: 792  DGLP-GPKGDV------GPNGQPGPM-------GPPGL----PGIGVQGPPGPPGIPGPI 833

Query: 770  GEH-----PQQEYGMGPRPFLPMSQGPGSNS--GLRNLREPIGPDQRTNSRLSHMPPLPL 822
            G+      P ++   GP P L +   PG     G+     PIGP           P LP 
Sbjct: 834  GQPGLHGIPGEKGDPGP-PGLDVPGPPGERGSPGIPGAPGPIGPPGS--------PGLPG 884

Query: 823  NPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGN 882
               ++            G    P  + + G      G+  LK     Q Q P L  P+G 
Sbjct: 885  KAGASGFPGTKGEMGMMGPPGPPGPLGIPGRS----GVPGLKGDDGLQGQ-PGLPGPTGE 939

Query: 883  LKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQ 942
              S   P      L GP        P +LGS          P LP   PG  S PK    
Sbjct: 940  KGSKGEPG-----LPGPPGPMD---PNLLGSKGEKG----EPGLPG-IPG-VSGPKGYQG 985

Query: 943  SPGIPPNHKAPLTMASPAMLGNVESGGPPPPTAS-----QPASVNIPGSLPSSTPYTMPP 997
             PG P           P + G     GPP P  +     QP  +  PG L  +      P
Sbjct: 986  LPGDP---------GQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPG-LKGTIGDMGFP 1035

Query: 998  EPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARS----PNLPSMNNM 1053
             P   + P             PS  P    +        D   P  S    P LP     
Sbjct: 1036 GPQGVEGPPG-----------PSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGE 1084

Query: 1054 PGMGINTQNPRISGP--NPVVPMPTLSPMGMTQPLSHSNQMPS-PNAVGPNIPP--HGVP 1108
            PG+     NP I G   +P +P    +P    QP      +P  P   GP  P    G P
Sbjct: 1085 PGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQP-----GLPGFPGTPGPPGPKGISGPP 1139

Query: 1109 MGPGLMSHNPIMGHGSQEPPMVPQGRMGFP--QGFPPV---QSPPQQVPFPHNGPSG--- 1160
              PGL      +G G       P G  G P   G P     +  P Q  F + GP G   
Sbjct: 1140 GNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPG 1199

Query: 1161 -----GQGSFPGGMGFPG-EGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSV 1214
                 G G  PG  G PG  GP G P              PG PG P      GN  P  
Sbjct: 1200 LSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPG-PALEGPKGNPGPQG 1258

Query: 1215 FTD-PDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGP-----GP 1268
                P  Q +  PG  G P    +  I  EK +      P   +PG K  QGP      P
Sbjct: 1259 PPGRPGFQGL--PGPEGPPGLPGNGGIKGEKGNPGQPGLPG--LPGLKGDQGPPGLQGNP 1314

Query: 1269 GFSHMQGMMGEQAPRMGLALPGMGGP-------GPVGTPDI--PLGTAPSMPGHNPMRPP 1319
            G   + GM G+         PGM GP       GP G P +  P G  P +PG +     
Sbjct: 1315 GRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGP-PGLPGPSGQ--- 1370

Query: 1320 AFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPG 1379
            + + +G  GP           +PGQP L   P           +GP GL    GP G PG
Sbjct: 1371 SIIIKGDAGP---------PGIPGQPGLKGLPGP---------QGPQGLPGPTGPPGDPG 1412

Query: 1380 M--MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
               +    G  G + +  +P Q   RG+    G  G    PG PG
Sbjct: 1413 RNGLPGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQGPPGPPG 1457



 Score =  120 bits (300), Expect = 1e-26
 Identities = 318/1316 (24%), Positives = 417/1316 (31%), Gaps = 205/1316 (15%)

Query: 231  PKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPR-PLDRESPGVENKLIPSV 289
            PK  P  P  P  Q             PP P     P  PP  P  + + G+ N   P  
Sbjct: 169  PKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGL-NFQGPKG 227

Query: 290  GSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEP-PTLGENP 348
                     PP   G  S           +G      D + PP PP   G P P  GE  
Sbjct: 228  EKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGD-RGPPGPPGIRGPPGPPGGEK- 285

Query: 349  DGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQA 408
             G   EQ E  +R                K     ++G P   PG+   P    E     
Sbjct: 286  -GEKGEQGEPGKRG---------------KPGKDGENGQPGI-PGLPGDPGYPGEPGRDG 328

Query: 409  MMAQSQSLGKG--PG---PRTDVGAPFGPQGHRDVPFSPDEMVP---PSMNSQSGTIGPD 460
               Q    G    PG   PR   G   G +G+  +P  P E      P +    G  GP 
Sbjct: 329  EKGQKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPGPP 388

Query: 461  HLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM 520
                M P           F  E+ +K ++                GP G+    PP    
Sbjct: 389  GAAVMGPPG------PPGFPGERGQKGDE----------------GPPGISIPGPPGLDG 426

Query: 521  TPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPG-----SQMRLPGFAGMINSEMEG 575
             P     PG   P    I     +   G    P  PG      +  + G  G       G
Sbjct: 427  QPGAPGLPGPPGPAGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIG 486

Query: 576  PNVPNPASRPGLSGVSWPDDVPKIPD--------GRNFPPG-QGIFSGPGRGERFPNPQG 626
              +  P  +PGL G+  P      P         G   P G  GI   PG    FP  +G
Sbjct: 487  TGISGPPGQPGLPGLPGPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPG-APGFPGSKG 545

Query: 627  LSEEM--FQQQLAEK-QLGLPPGMAMEGI--RPSMEMNRMIPGSQRHMEPGNNPIFPRIP 681
               ++  F     +K +LG P    + G+   P  +    +PG +   EPG       I 
Sbjct: 546  EPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGLPGLPGPKG--EPGG------IT 597

Query: 682  VEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQM-IPQKMREA 740
             +G   P       G+P  +GP     FG  P G  G+  +    G+  Q  IP    + 
Sbjct: 598  FKGERGPPGNPGLPGLPGNIGPMGPPGFG--PPGPVGEKGIQGVAGNPGQPGIPGPKGDP 655

Query: 741  GAGPEEM----LKLRPG--------GSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMS 788
            G    +     L   PG        G   LP Q  +  +P  +      G+G    LP  
Sbjct: 656  GQTITQPGKPGLPGNPGRDGDVGLPGDPGLPGQPGLPGIPGSKGEPGIPGIG----LPGP 711

Query: 789  QGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDI 848
             GP    G+       G   R        PP    P   P      PP   GL      +
Sbjct: 712  PGPKGFPGIPGPPGAPGTPGRIGLEGPPGPPGFPGPKGEPGFALPGPPGPPGLPGFKGAL 771

Query: 849  SVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGM-LAGPAAAASIKS 907
               G +       P     +  +  P           P  P  L G+ + GP     I  
Sbjct: 772  GPKGDRGFPGPPGPPGRTGLDGLPGPKGDVGPNGQPGPMGPPGLPGIGVQGPPGPPGIPG 831

Query: 908  P---PVLGSAAASPVHLKSPSLPAP-------SPGWTSSPKP--PLQSPGIPPNHKAPLT 955
            P   P L            P L  P       SPG   +P P  P  SPG+P    A   
Sbjct: 832  PIGQPGLHGIPGEKGDPGPPGLDVPGPPGERGSPGIPGAPGPIGPPGSPGLPGKAGASGF 891

Query: 956  MASPAMLGNVESGGPPPPTASQPASVNIPG-----------SLPSST-PYTMPPEPTLSQ 1003
              +   +G +   GPP P    P    +PG            LP  T       EP L  
Sbjct: 892  PGTKGEMGMMGPPGPPGPLGI-PGRSGVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPG 950

Query: 1004 NPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGM---GINT 1060
             P  +  + +          L    I  V+           P  P ++  PG+       
Sbjct: 951  PPGPMDPNLLGSKGEKGEPGL--PGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPK 1008

Query: 1061 QNPRISGPNPVVPMPTL----------SPMGMTQPLSHSNQMPSPNAVG----------P 1100
             NP + G   ++  P L           P G+  P   S     P + G          P
Sbjct: 1009 GNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDP 1068

Query: 1101 NIPPHGVPMGPGLMSHNPIMGH-------GSQEPPMVP--------QGRMGFPQGFPPVQ 1145
             I   G+P  PG      + G+       GS   P +P        +G+ G P GFP   
Sbjct: 1069 GISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLP-GFPGTP 1127

Query: 1146 SPPQQVPFPHNGPSGGQGSFPGGMGFPGE-GPLGRPSNLPQSSADAALCKPGGPGGPDSF 1204
             PP        GP G  G  PG  G PGE GP+G   +  Q        KPG  G P   
Sbjct: 1128 GPP--------GPKGISGP-PGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPA 1178

Query: 1205 TVLGNSMPSVFTDPDLQEVI----RPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGR 1260
               G      F +P    +     + G  G+P    +  +P  K       FP  + P  
Sbjct: 1179 GQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGP-P 1237

Query: 1261 KQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGG-PGPVGTPDIPLGTA-------PSMPG 1312
              P  PGP     +G  G Q P      PG  G PGP G P +P           P  PG
Sbjct: 1238 GPPGSPGPALEGPKGNPGPQGPP---GRPGFQGLPGPEGPPGLPGNGGIKGEKGNPGQPG 1294

Query: 1313 HNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHP 1372
              P  P     QG  G       P  + M G P L   P       PG  +GP+G+    
Sbjct: 1295 -LPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVPG-----FPGM-KGPSGVPGSA 1347

Query: 1373 GPVGSPGMM--MSMQGMMGPQ-QNIMIPPQMRPRGMAADVGMGGF--SQGP-GNPG 1422
            GP G PG++      G+ GP  Q+I+I     P G+    G+ G    QGP G PG
Sbjct: 1348 GPEGEPGLIGPPGPPGLPGPSGQSIIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPG 1403



 Score =  115 bits (288), Expect = 3e-25
 Identities = 261/987 (26%), Positives = 330/987 (33%), Gaps = 208/987 (21%)

Query: 506  GPRGVVRGPP--PPYQMTPSEGWAPGGTEPFSDGINMPHSLP-------PRGMAPHPNMP 556
            GP+G+ RGPP  P +  TP     PG      DG   P  +P        RG    P  P
Sbjct: 87   GPKGI-RGPPGLPGFPGTPGLPGMPG-----HDGAPGPQGIPGCNGTKGERGFPGSPGFP 140

Query: 557  GSQ-----MRLPGFAG----MINSEMEGPNV-PNPASRPGLSGVSWPDDVPKIPDGRNFP 606
            G Q       +PG  G    +I S + GP   P     PG+ G+  P  +P    G   P
Sbjct: 141  GLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPGIQGLPGPTGIP----GPIGP 196

Query: 607  PGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEK-QLGL-----PPGMAMEGIRP-SMEMN 659
            PG     GP      P P+G     FQ    EK + GL     PPG   E  RP  +E  
Sbjct: 197  PGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQ 256

Query: 660  RMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDF----PKGIPPQMG-PGRELEFGM--V 712
            +   G      P   P      + GP  P  G+      +G P + G PG++ E G   +
Sbjct: 257  KGDQGLPGDRGPPGPP-----GIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGI 311

Query: 713  PSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPG-----------GSDMLPAQ 761
            P G+ GD       G + +   QK      GP  ++  RPG           G   LP +
Sbjct: 312  P-GLPGDPGYPGEPGRDGEK-GQKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGE 369

Query: 762  QKMVPLPFGEHPQQEYG------MGPR--PFLPMSQGPGSNSGLRNLREPIGP--DQRTN 811
            +     P  + P    G      MGP   P  P  +G   + G   +  P  P  D +  
Sbjct: 370  KGERGFPGIQGPPGLPGPPGAAVMGPPGPPGFPGERGQKGDEGPPGISIPGPPGLDGQPG 429

Query: 812  SRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQV 871
            +     PP P  P   P+      P   G    P D  + G Q    G+   K  T    
Sbjct: 430  APGLPGPPGPAGPHIPPSD-EICEPGPPGPPGSPGDKGLQGEQ----GVKGDKGDTCFNC 484

Query: 872  QSPMLGSPSGNLKSPQTPSQLAGM-------LAGPAAAASIKSPPVLGSAAASPVHLKSP 924
                +  P G    P  P     +         G A A   K  P +  A  +P    S 
Sbjct: 485  IGTGISGPPGQPGLPGLPGPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSK 544

Query: 925  SLPAPS---PGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASV 981
              P      PG     K  L SPG P           P + G     G P      P   
Sbjct: 545  GEPGDILTFPGMKGD-KGELGSPGAP---------GLPGLPGTPGQDGLP----GLPGPK 590

Query: 982  NIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPP 1041
              PG +        P  P L   P +I       F  P   P+    I+ VA +      
Sbjct: 591  GEPGGITFKGERGPPGNPGLPGLPGNIGPMGPPGFGPPG--PVGEKGIQGVAGNPGQ--- 645

Query: 1042 ARSPNLPSMNNMPGMGINTQN-PRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVG- 1099
               P +P     PG  I     P + G NP                     +  P   G 
Sbjct: 646  ---PGIPGPKGDPGQTITQPGKPGLPG-NP----------------GRDGDVGLPGDPGL 685

Query: 1100 PNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPS 1159
            P  P  G+P  PG      I G G   PP         P+GFP +  PP     P  G  
Sbjct: 686  PGQP--GLPGIPGSKGEPGIPGIGLPGPPG--------PKGFPGIPGPPGAPGTP--GRI 733

Query: 1160 GGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPD 1219
            G +G  PG  GFPG  P G P         A    PG PG P     LG      F  P 
Sbjct: 734  GLEGP-PGPPGFPG--PKGEPGF-------ALPGPPGPPGLPGFKGALGPKGDRGFPGPP 783

Query: 1220 LQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGE 1279
                  PG TG+                         +PG K   GP           G+
Sbjct: 784  GP----PGRTGLDG-----------------------LPGPKGDVGPN----------GQ 806

Query: 1280 QAPRMGLALPGMGGPGPVGTPDI--PLGT--APSMPGHNPMRPPAFLQQGMMGPHHRMMS 1335
              P     LPG+G  GP G P I  P+G      +PG      P  L   + GP     S
Sbjct: 807  PGPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLD--VPGPPGERGS 864

Query: 1336 PAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIM 1395
            P    +PG P  +  P +    +PGK    AG    PG  G  GMM    G  GP   + 
Sbjct: 865  PG---IPGAPGPIGPPGSP--GLPGK----AGASGFPGTKGEMGMM----GPPGPPGPLG 911

Query: 1396 IPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            IP +    G+  D G+ G    PG PG
Sbjct: 912  IPGRSGVPGLKGDDGLQG---QPGLPG 935



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 135/476 (28%), Positives = 174/476 (36%), Gaps = 112/476 (23%)

Query: 1041 PARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGP 1100
            P   P +P M   PG  I +  P   G NP  P     P G+ Q L     +P P  +GP
Sbjct: 145  PPGPPGIPGMKGEPGSIIMSSLPGPKG-NPGYP----GPPGI-QGLPGPTGIPGP--IGP 196

Query: 1101 NIPPH--GVPMGPGLMSHNPIMG------------HGSQEPPMVP--------------- 1131
              PP   G P  PGL      MG             G Q PP  P               
Sbjct: 197  PGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQ 256

Query: 1132 QGRMGFP-----QGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPG-EGPLGRPSNLPQ 1185
            +G  G P      G P ++ PP   P    G  G QG  PG  G PG +G  G+P  +P 
Sbjct: 257  KGDQGLPGDRGPPGPPGIRGPPGP-PGGEKGEKGEQGE-PGKRGKPGKDGENGQPG-IPG 313

Query: 1186 SSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRI----IP 1241
               D     PG PG P      G    +    P    + RPG TGI   +   I    +P
Sbjct: 314  LPGD-----PGYPGEPGRDGEKGQKGDTGPPGPPGLVIPRPG-TGITIGEKGNIGLPGLP 367

Query: 1242 SEKPSQTLQYFPRGE-VPGRKQPQG------PGP-GFSHMQGMMGEQAPRMGLALPGMGG 1293
             EK  +    FP  +  PG   P G      PGP GF   +G  G++ P  G+++PG  G
Sbjct: 368  GEKGERG---FPGIQGPPGLPGPPGAAVMGPPGPPGFPGERGQKGDEGPP-GISIPGPPG 423

Query: 1294 ----PGPVGTPDIPLGTAPSMPGHN------PMRPPAFL-------QQGMMGPH----HR 1332
                PG  G P  P    P +P  +      P  PP          +QG+ G        
Sbjct: 424  LDGQPGAPGLPGPPGPAGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFN 483

Query: 1333 MMSPAQSTMPGQPTL--MSNPAAAVGMIPGKD--------RGPAGLYT---------HPG 1373
             +    S  PGQP L  +  P  ++G  PG+          GP GL            PG
Sbjct: 484  CIGTGISGPPGQPGLPGLPGPPGSLGF-PGQKGEKGQAGATGPKGLPGIPGAPGAPGFPG 542

Query: 1374 PVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGP---GNPGNMMF 1426
              G PG +++  GM G +  +  P      G+    G  G    P   G PG + F
Sbjct: 543  SKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGLPGLPGPKGEPGGITF 598



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 100/329 (30%), Positives = 119/329 (36%), Gaps = 73/329 (22%)

Query: 1111 PGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMG 1170
            PGL  H  + G    E P  P+G+ G   G P    PP   P    GP G  G FPG  G
Sbjct: 53   PGLEGHPGLPGFPGPEGPPGPRGQKG-DDGIP---GPPG--PKGIRGPPGLPG-FPGTPG 105

Query: 1171 FPG-EGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGAT 1229
             PG  G  G P        +    + G PG P                P LQ    PG  
Sbjct: 106  LPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGF--------------PGLQGP--PGPP 149

Query: 1230 GIPEF--DLSRIIPSEKPSQTLQYFPRGEVPGRKQPQG----PGPGFSHMQGMMGEQAPR 1283
            GIP    +   II S  P       P+G  PG   P G    PGP  + + G +G   P 
Sbjct: 150  GIPGMKGEPGSIIMSSLPG------PKGN-PGYPGPPGIQGLPGP--TGIPGPIGPPGP- 199

Query: 1284 MGLALPG-MGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFL-QQGMMGPHHRMMSPAQSTM 1341
                 PG MG PGP G P  P G      G N   P     +QG+ GP            
Sbjct: 200  -----PGLMGPPGPPGLPG-PKGNM----GLNFQGPKGEKGEQGLQGP------------ 237

Query: 1342 PGQPTLMSNPAAAVGM--------IPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQN 1393
            PG P  +S     + +        +PG DRGP G     GP G PG     +G  G    
Sbjct: 238  PGPPGQISEQKRPIDVEFQKGDQGLPG-DRGPPGPPGIRGPPGPPGGEKGEKGEQGEPGK 296

Query: 1394 IMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
               P +    G     G+ G    PG PG
Sbjct: 297  RGKPGKDGENGQPGIPGLPGDPGYPGEPG 325



 Score = 37.7 bits (86), Expect = 0.080
 Identities = 31/92 (33%), Positives = 38/92 (41%), Gaps = 16/92 (17%)

Query: 1343 GQPTLMSNPAAAVGMIPGK------------DRGPAGLYTHPGPVGSPGMMMSMQGMMGP 1390
            GQP   +  AA  G  PG             +RG  GL  HPG  G PG      G  G 
Sbjct: 21   GQP---AEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPG-PEGPPGPRGQ 76

Query: 1391 QQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            + +  IP    P+G+    G+ GF   PG PG
Sbjct: 77   KGDDGIPGPPGPKGIRGPPGLPGFPGTPGLPG 108



 Score = 33.5 bits (75), Expect = 1.5
 Identities = 29/98 (29%), Positives = 36/98 (36%), Gaps = 16/98 (16%)

Query: 36  PSGNPQLDSKFSNQGKQG--GSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGA 93
           P GNP        QG  G  G      P       G   P  LPGP G+MGL      G 
Sbjct: 169 PKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGE 228

Query: 94  KGK-------------GKRERSISADSFDQRDPGTPND 118
           KG+              +++R I  + F + D G P D
Sbjct: 229 KGEQGLQGPPGPPGQISEQKRPIDVE-FQKGDQGLPGD 265


>gi|4502955 type IV collagen alpha 5 isoform 1 precursor [Homo
            sapiens]
          Length = 1685

 Score =  126 bits (317), Expect = 1e-28
 Identities = 326/1244 (26%), Positives = 408/1244 (32%), Gaps = 251/1244 (20%)

Query: 256  PTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVT 315
            P PP  A    P  P  P +R   G E       G P  S P PP   G    P      
Sbjct: 385  PGPPGAAVMGPPGPPGFPGERGQKGDE-------GPPGISIPGPPGLDGQPGAPGLPG-P 436

Query: 316  PVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFP 375
            P   G +   +D    P PP   G P        GL  EQ    ++       I      
Sbjct: 437  PGPAGPHIPPSDEICEPGPPGPPGSP-----GDKGLQGEQGVKGDKGDTCFNCI------ 485

Query: 376  DEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGH 435
                  G    GP   PG+   P     GP  ++    Q   KG    T      GP+G 
Sbjct: 486  ------GTGISGPPGQPGLPGLP-----GPPGSLGFPGQKGEKGQAGAT------GPKGL 528

Query: 436  RDVPFSP-------------DEMVPPSMNSQSGTIGPDHLDHM-----TPEQIAWLKLQQ 477
              +P +P             D +  P M    G +G      +     TP Q     L  
Sbjct: 529  PGIPGAPGAPGFPGSKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGLPGLPG 588

Query: 478  EFYEEK--RRKQEQVVVQQCSLQDMM--VHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEP 533
               E      K E+       L  +   +   GP G   GPP P      +G A    +P
Sbjct: 589  PKGEPGGITFKGERGPPGNPGLPGLPGNIGPMGPPGF--GPPGPVGEKGIQGVAGNPGQP 646

Query: 534  FSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWP 593
               GI  P   P + +   P  PG    LPG  G  + ++  P  P    +PGL G+   
Sbjct: 647  ---GIPGPKGDPGQTIT-QPGKPG----LPGNPGR-DGDVGLPGDPGLPGQPGLPGIPGS 697

Query: 594  DDVPKIPD-GRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGI 652
               P IP  G   PPG   F G       P P G               G P  + +EG 
Sbjct: 698  KGEPGIPGIGLPGPPGPKGFPG------IPGPPGAP-------------GTPGRIGLEGP 738

Query: 653  R--PSMEMNRMIPGSQRHMEPGNNPIFPRIP-VEGPLSPSRGDFPKGIPPQMGPGRELEF 709
               P     +  PG      PG     P +P  +G L P +GD  +G P   GP      
Sbjct: 739  PGPPGFPGPKGEPGFALPGPPGP----PGLPGFKGALGP-KGD--RGFPGPPGPPGRTGL 791

Query: 710  GMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPF 769
              +P G KGDV      G N Q  P        GP  +    PG     P     +P P 
Sbjct: 792  DGLP-GPKGDV------GPNGQPGPM-------GPPGL----PGIGVQGPPGPPGIPGPI 833

Query: 770  GEH-----PQQEYGMGPRPFLPMSQGPGSNS--GLRNLREPIGPDQRTNSRLSHMPPLPL 822
            G+      P ++   GP P L +   PG     G+     PIGP           P LP 
Sbjct: 834  GQPGLHGIPGEKGDPGP-PGLDVPGPPGERGSPGIPGAPGPIGPPGS--------PGLPG 884

Query: 823  NPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGN 882
               ++            G    P  + + G      G+  LK     Q Q P L  P+G 
Sbjct: 885  KAGASGFPGTKGEMGMMGPPGPPGPLGIPGRS----GVPGLKGDDGLQGQ-PGLPGPTGE 939

Query: 883  LKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQ 942
              S   P      L GP        P +LGS          P LP   PG  S PK    
Sbjct: 940  KGSKGEPG-----LPGPPGPMD---PNLLGSKGEKG----EPGLPG-IPG-VSGPKGYQG 985

Query: 943  SPGIPPNHKAPLTMASPAMLGNVESGGPPPPTAS-----QPASVNIPGSLPSSTPYTMPP 997
             PG P           P + G     GPP P  +     QP  +  PG L  +      P
Sbjct: 986  LPGDP---------GQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPG-LKGTIGDMGFP 1035

Query: 998  EPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARS----PNLPSMNNM 1053
             P   + P             PS  P    +        D   P  S    P LP     
Sbjct: 1036 GPQGVEGPPG-----------PSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGE 1084

Query: 1054 PGMGINTQNPRISGP--NPVVPMPTLSPMGMTQPLSHSNQMPS-PNAVGPNIPP--HGVP 1108
            PG+     NP I G   +P +P    +P    QP      +P  P   GP  P    G P
Sbjct: 1085 PGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQP-----GLPGFPGTPGPPGPKGISGPP 1139

Query: 1109 MGPGLMSHNPIMGHGSQEPPMVPQGRMGFP--QGFPPV---QSPPQQVPFPHNGPSG--- 1160
              PGL      +G G       P G  G P   G P     +  P Q  F + GP G   
Sbjct: 1140 GNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPG 1199

Query: 1161 -----GQGSFPGGMGFPG-EGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSV 1214
                 G G  PG  G PG  GP G P              PG PG P      GN  P  
Sbjct: 1200 LSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPG-PALEGPKGNPGPQ- 1257

Query: 1215 FTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGP-----GPG 1269
               P  +  + PG  G P    +  I  EK +      P   +PG K  QGP      PG
Sbjct: 1258 --GPPGRPGL-PGPEGPPGLPGNGGIKGEKGNPGQPGLPG--LPGLKGDQGPPGLQGNPG 1312

Query: 1270 FSHMQGMMGEQAPRMGLALPGMGGP-------GPVGTPDI--PLGTAPSMPGHNPMRPPA 1320
               + GM G+         PGM GP       GP G P +  P G  P +PG +     +
Sbjct: 1313 RPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGP-PGLPGPSGQ---S 1368

Query: 1321 FLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGM 1380
             + +G  GP           +PGQP L   P           +GP GL    GP G PG 
Sbjct: 1369 IIIKGDAGP---------PGIPGQPGLKGLPGP---------QGPQGLPGPTGPPGDPGR 1410

Query: 1381 --MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
              +    G  G + +  +P Q   RG+    G  G    PG PG
Sbjct: 1411 NGLPGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQGPPGPPG 1454



 Score =  120 bits (300), Expect = 1e-26
 Identities = 318/1316 (24%), Positives = 417/1316 (31%), Gaps = 208/1316 (15%)

Query: 231  PKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPR-PLDRESPGVENKLIPSV 289
            PK  P  P  P  Q             PP P     P  PP  P  + + G+ N   P  
Sbjct: 169  PKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGL-NFQGPKG 227

Query: 290  GSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEP-PTLGENP 348
                     PP   G  S           +G      D + PP PP   G P P  GE  
Sbjct: 228  EKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGD-RGPPGPPGIRGPPGPPGGEK- 285

Query: 349  DGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQA 408
             G   EQ E  +R                K     ++G P   PG+   P    E     
Sbjct: 286  -GEKGEQGEPGKRG---------------KPGKDGENGQPGI-PGLPGDPGYPGEPGRDG 328

Query: 409  MMAQSQSLGKG--PG---PRTDVGAPFGPQGHRDVPFSPDEMVP---PSMNSQSGTIGPD 460
               Q    G    PG   PR   G   G +G+  +P  P E      P +    G  GP 
Sbjct: 329  EKGQKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPGPP 388

Query: 461  HLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM 520
                M P           F  E+ +K ++                GP G+    PP    
Sbjct: 389  GAAVMGPPG------PPGFPGERGQKGDE----------------GPPGISIPGPPGLDG 426

Query: 521  TPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPG-----SQMRLPGFAGMINSEMEG 575
             P     PG   P    I     +   G    P  PG      +  + G  G       G
Sbjct: 427  QPGAPGLPGPPGPAGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIG 486

Query: 576  PNVPNPASRPGLSGVSWPDDVPKIPD--------GRNFPPG-QGIFSGPGRGERFPNPQG 626
              +  P  +PGL G+  P      P         G   P G  GI   PG    FP  +G
Sbjct: 487  TGISGPPGQPGLPGLPGPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPG-APGFPGSKG 545

Query: 627  LSEEM--FQQQLAEK-QLGLPPGMAMEGI--RPSMEMNRMIPGSQRHMEPGNNPIFPRIP 681
               ++  F     +K +LG P    + G+   P  +    +PG +   EPG       I 
Sbjct: 546  EPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGLPGLPGPKG--EPGG------IT 597

Query: 682  VEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQM-IPQKMREA 740
             +G   P       G+P  +GP     FG  P G  G+  +    G+  Q  IP    + 
Sbjct: 598  FKGERGPPGNPGLPGLPGNIGPMGPPGFG--PPGPVGEKGIQGVAGNPGQPGIPGPKGDP 655

Query: 741  GAGPEEM----LKLRPG--------GSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMS 788
            G    +     L   PG        G   LP Q  +  +P  +      G+G    LP  
Sbjct: 656  GQTITQPGKPGLPGNPGRDGDVGLPGDPGLPGQPGLPGIPGSKGEPGIPGIG----LPGP 711

Query: 789  QGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDI 848
             GP    G+       G   R        PP    P   P      PP   GL      +
Sbjct: 712  PGPKGFPGIPGPPGAPGTPGRIGLEGPPGPPGFPGPKGEPGFALPGPPGPPGLPGFKGAL 771

Query: 849  SVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGM-LAGPAAAASIKS 907
               G +       P     +  +  P           P  P  L G+ + GP     I  
Sbjct: 772  GPKGDRGFPGPPGPPGRTGLDGLPGPKGDVGPNGQPGPMGPPGLPGIGVQGPPGPPGIPG 831

Query: 908  P---PVLGSAAASPVHLKSPSLPAP-------SPGWTSSPKP--PLQSPGIPPNHKAPLT 955
            P   P L            P L  P       SPG   +P P  P  SPG+P    A   
Sbjct: 832  PIGQPGLHGIPGEKGDPGPPGLDVPGPPGERGSPGIPGAPGPIGPPGSPGLPGKAGASGF 891

Query: 956  MASPAMLGNVESGGPPPPTASQPASVNIPG-----------SLPSST-PYTMPPEPTLSQ 1003
              +   +G +   GPP P    P    +PG            LP  T       EP L  
Sbjct: 892  PGTKGEMGMMGPPGPPGPLGI-PGRSGVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPG 950

Query: 1004 NPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGM---GINT 1060
             P  +  + +          L    I  V+           P  P ++  PG+       
Sbjct: 951  PPGPMDPNLLGSKGEKGEPGL--PGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPK 1008

Query: 1061 QNPRISGPNPVVPMPTL----------SPMGMTQPLSHSNQMPSPNAVG----------P 1100
             NP + G   ++  P L           P G+  P   S     P + G          P
Sbjct: 1009 GNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDP 1068

Query: 1101 NIPPHGVPMGPGLMSHNPIMGH-------GSQEPPMVP--------QGRMGFPQGFPPVQ 1145
             I   G+P  PG      + G+       GS   P +P        +G+ G P GFP   
Sbjct: 1069 GISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLP-GFPGTP 1127

Query: 1146 SPPQQVPFPHNGPSGGQGSFPGGMGFPGE-GPLGRPSNLPQSSADAALCKPGGPGGPDSF 1204
             PP        GP G  G  PG  G PGE GP+G   +  Q        KPG  G P   
Sbjct: 1128 GPP--------GPKGISGP-PGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPA 1178

Query: 1205 TVLGNSMPSVFTDPDLQEVI----RPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGR 1260
               G      F +P    +     + G  G+P    +  +P  K       FP  + P  
Sbjct: 1179 GQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGP-P 1237

Query: 1261 KQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGG-PGPVGTPDIPLGTA-------PSMPG 1312
              P  PGP     +G  G Q P      PG  G PGP G P +P           P  PG
Sbjct: 1238 GPPGSPGPALEGPKGNPGPQGP------PGRPGLPGPEGPPGLPGNGGIKGEKGNPGQPG 1291

Query: 1313 HNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHP 1372
              P  P     QG  G       P  + M G P L   P       PG  +GP+G+    
Sbjct: 1292 -LPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVPG-----FPGM-KGPSGVPGSA 1344

Query: 1373 GPVGSPGMM--MSMQGMMGPQ-QNIMIPPQMRPRGMAADVGMGGF--SQGP-GNPG 1422
            GP G PG++      G+ GP  Q+I+I     P G+    G+ G    QGP G PG
Sbjct: 1345 GPEGEPGLIGPPGPPGLPGPSGQSIIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPG 1400



 Score =  115 bits (288), Expect = 3e-25
 Identities = 261/987 (26%), Positives = 330/987 (33%), Gaps = 208/987 (21%)

Query: 506  GPRGVVRGPP--PPYQMTPSEGWAPGGTEPFSDGINMPHSLP-------PRGMAPHPNMP 556
            GP+G+ RGPP  P +  TP     PG      DG   P  +P        RG    P  P
Sbjct: 87   GPKGI-RGPPGLPGFPGTPGLPGMPG-----HDGAPGPQGIPGCNGTKGERGFPGSPGFP 140

Query: 557  GSQ-----MRLPGFAG----MINSEMEGPNV-PNPASRPGLSGVSWPDDVPKIPDGRNFP 606
            G Q       +PG  G    +I S + GP   P     PG+ G+  P  +P    G   P
Sbjct: 141  GLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPGIQGLPGPTGIP----GPIGP 196

Query: 607  PGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEK-QLGL-----PPGMAMEGIRP-SMEMN 659
            PG     GP      P P+G     FQ    EK + GL     PPG   E  RP  +E  
Sbjct: 197  PGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQ 256

Query: 660  RMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDF----PKGIPPQMG-PGRELEFGM--V 712
            +   G      P   P      + GP  P  G+      +G P + G PG++ E G   +
Sbjct: 257  KGDQGLPGDRGPPGPP-----GIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGI 311

Query: 713  PSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPG-----------GSDMLPAQ 761
            P G+ GD       G + +   QK      GP  ++  RPG           G   LP +
Sbjct: 312  P-GLPGDPGYPGEPGRDGEK-GQKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGE 369

Query: 762  QKMVPLPFGEHPQQEYG------MGPR--PFLPMSQGPGSNSGLRNLREPIGP--DQRTN 811
            +     P  + P    G      MGP   P  P  +G   + G   +  P  P  D +  
Sbjct: 370  KGERGFPGIQGPPGLPGPPGAAVMGPPGPPGFPGERGQKGDEGPPGISIPGPPGLDGQPG 429

Query: 812  SRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQV 871
            +     PP P  P   P+      P   G    P D  + G Q    G+   K  T    
Sbjct: 430  APGLPGPPGPAGPHIPPSD-EICEPGPPGPPGSPGDKGLQGEQ----GVKGDKGDTCFNC 484

Query: 872  QSPMLGSPSGNLKSPQTPSQLAGM-------LAGPAAAASIKSPPVLGSAAASPVHLKSP 924
                +  P G    P  P     +         G A A   K  P +  A  +P    S 
Sbjct: 485  IGTGISGPPGQPGLPGLPGPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSK 544

Query: 925  SLPAPS---PGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASV 981
              P      PG     K  L SPG P           P + G     G P      P   
Sbjct: 545  GEPGDILTFPGMKGD-KGELGSPGAP---------GLPGLPGTPGQDGLP----GLPGPK 590

Query: 982  NIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPP 1041
              PG +        P  P L   P +I       F  P   P+    I+ VA +      
Sbjct: 591  GEPGGITFKGERGPPGNPGLPGLPGNIGPMGPPGFGPPG--PVGEKGIQGVAGNPGQ--- 645

Query: 1042 ARSPNLPSMNNMPGMGINTQN-PRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVG- 1099
               P +P     PG  I     P + G NP                     +  P   G 
Sbjct: 646  ---PGIPGPKGDPGQTITQPGKPGLPG-NP----------------GRDGDVGLPGDPGL 685

Query: 1100 PNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPS 1159
            P  P  G+P  PG      I G G   PP         P+GFP +  PP     P  G  
Sbjct: 686  PGQP--GLPGIPGSKGEPGIPGIGLPGPPG--------PKGFPGIPGPPGAPGTP--GRI 733

Query: 1160 GGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPD 1219
            G +G  PG  GFPG  P G P         A    PG PG P     LG      F  P 
Sbjct: 734  GLEGP-PGPPGFPG--PKGEPGF-------ALPGPPGPPGLPGFKGALGPKGDRGFPGPP 783

Query: 1220 LQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGE 1279
                  PG TG+                         +PG K   GP           G+
Sbjct: 784  GP----PGRTGLDG-----------------------LPGPKGDVGPN----------GQ 806

Query: 1280 QAPRMGLALPGMGGPGPVGTPDI--PLGT--APSMPGHNPMRPPAFLQQGMMGPHHRMMS 1335
              P     LPG+G  GP G P I  P+G      +PG      P  L   + GP     S
Sbjct: 807  PGPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLD--VPGPPGERGS 864

Query: 1336 PAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIM 1395
            P    +PG P  +  P +    +PGK    AG    PG  G  GMM    G  GP   + 
Sbjct: 865  PG---IPGAPGPIGPPGSP--GLPGK----AGASGFPGTKGEMGMM----GPPGPPGPLG 911

Query: 1396 IPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            IP +    G+  D G+ G    PG PG
Sbjct: 912  IPGRSGVPGLKGDDGLQG---QPGLPG 935



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 135/476 (28%), Positives = 174/476 (36%), Gaps = 112/476 (23%)

Query: 1041 PARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGP 1100
            P   P +P M   PG  I +  P   G NP  P     P G+ Q L     +P P  +GP
Sbjct: 145  PPGPPGIPGMKGEPGSIIMSSLPGPKG-NPGYP----GPPGI-QGLPGPTGIPGP--IGP 196

Query: 1101 NIPPH--GVPMGPGLMSHNPIMG------------HGSQEPPMVP--------------- 1131
              PP   G P  PGL      MG             G Q PP  P               
Sbjct: 197  PGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQ 256

Query: 1132 QGRMGFP-----QGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPG-EGPLGRPSNLPQ 1185
            +G  G P      G P ++ PP   P    G  G QG  PG  G PG +G  G+P  +P 
Sbjct: 257  KGDQGLPGDRGPPGPPGIRGPPGP-PGGEKGEKGEQGE-PGKRGKPGKDGENGQPG-IPG 313

Query: 1186 SSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRI----IP 1241
               D     PG PG P      G    +    P    + RPG TGI   +   I    +P
Sbjct: 314  LPGD-----PGYPGEPGRDGEKGQKGDTGPPGPPGLVIPRPG-TGITIGEKGNIGLPGLP 367

Query: 1242 SEKPSQTLQYFPRGE-VPGRKQPQG------PGP-GFSHMQGMMGEQAPRMGLALPGMGG 1293
             EK  +    FP  +  PG   P G      PGP GF   +G  G++ P  G+++PG  G
Sbjct: 368  GEKGERG---FPGIQGPPGLPGPPGAAVMGPPGPPGFPGERGQKGDEGPP-GISIPGPPG 423

Query: 1294 ----PGPVGTPDIPLGTAPSMPGHN------PMRPPAFL-------QQGMMGPH----HR 1332
                PG  G P  P    P +P  +      P  PP          +QG+ G        
Sbjct: 424  LDGQPGAPGLPGPPGPAGPHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFN 483

Query: 1333 MMSPAQSTMPGQPTL--MSNPAAAVGMIPGKD--------RGPAGLYT---------HPG 1373
             +    S  PGQP L  +  P  ++G  PG+          GP GL            PG
Sbjct: 484  CIGTGISGPPGQPGLPGLPGPPGSLGF-PGQKGEKGQAGATGPKGLPGIPGAPGAPGFPG 542

Query: 1374 PVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGP---GNPGNMMF 1426
              G PG +++  GM G +  +  P      G+    G  G    P   G PG + F
Sbjct: 543  SKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGTPGQDGLPGLPGPKGEPGGITF 598



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 100/329 (30%), Positives = 119/329 (36%), Gaps = 73/329 (22%)

Query: 1111 PGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMG 1170
            PGL  H  + G    E P  P+G+ G   G P    PP   P    GP G  G FPG  G
Sbjct: 53   PGLEGHPGLPGFPGPEGPPGPRGQKG-DDGIP---GPPG--PKGIRGPPGLPG-FPGTPG 105

Query: 1171 FPG-EGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGAT 1229
             PG  G  G P        +    + G PG P                P LQ    PG  
Sbjct: 106  LPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGF--------------PGLQGP--PGPP 149

Query: 1230 GIPEF--DLSRIIPSEKPSQTLQYFPRGEVPGRKQPQG----PGPGFSHMQGMMGEQAPR 1283
            GIP    +   II S  P       P+G  PG   P G    PGP  + + G +G   P 
Sbjct: 150  GIPGMKGEPGSIIMSSLPG------PKGN-PGYPGPPGIQGLPGP--TGIPGPIGPPGP- 199

Query: 1284 MGLALPG-MGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFL-QQGMMGPHHRMMSPAQSTM 1341
                 PG MG PGP G P  P G      G N   P     +QG+ GP            
Sbjct: 200  -----PGLMGPPGPPGLPG-PKGNM----GLNFQGPKGEKGEQGLQGP------------ 237

Query: 1342 PGQPTLMSNPAAAVGM--------IPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQN 1393
            PG P  +S     + +        +PG DRGP G     GP G PG     +G  G    
Sbjct: 238  PGPPGQISEQKRPIDVEFQKGDQGLPG-DRGPPGPPGIRGPPGPPGGEKGEKGEQGEPGK 296

Query: 1394 IMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
               P +    G     G+ G    PG PG
Sbjct: 297  RGKPGKDGENGQPGIPGLPGDPGYPGEPG 325



 Score = 37.7 bits (86), Expect = 0.080
 Identities = 31/92 (33%), Positives = 38/92 (41%), Gaps = 16/92 (17%)

Query: 1343 GQPTLMSNPAAAVGMIPGK------------DRGPAGLYTHPGPVGSPGMMMSMQGMMGP 1390
            GQP   +  AA  G  PG             +RG  GL  HPG  G PG      G  G 
Sbjct: 21   GQP---AEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPG-PEGPPGPRGQ 76

Query: 1391 QQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            + +  IP    P+G+    G+ GF   PG PG
Sbjct: 77   KGDDGIPGPPGPKGIRGPPGLPGFPGTPGLPG 108



 Score = 33.5 bits (75), Expect = 1.5
 Identities = 29/98 (29%), Positives = 36/98 (36%), Gaps = 16/98 (16%)

Query: 36  PSGNPQLDSKFSNQGKQG--GSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGA 93
           P GNP        QG  G  G      P       G   P  LPGP G+MGL      G 
Sbjct: 169 PKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGE 228

Query: 94  KGK-------------GKRERSISADSFDQRDPGTPND 118
           KG+              +++R I  + F + D G P D
Sbjct: 229 KGEQGLQGPPGPPGQISEQKRPIDVE-FQKGDQGLPGD 265


>gi|148536825 alpha 1 type IV collagen preproprotein [Homo sapiens]
          Length = 1669

 Score =  115 bits (289), Expect = 2e-25
 Identities = 302/1238 (24%), Positives = 379/1238 (30%), Gaps = 268/1238 (21%)

Query: 233  PLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPK---PAAPPRPLDRESPGVENKLIPSV 289
            P+P Q  AP    +   +  R  P   +P P+ +   P  P  P     PG  N ++   
Sbjct: 376  PVPGQAGAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNGIV--- 432

Query: 290  GSPASSTPLPPDGTGPNSTPNNRAVTPV--SQGSNSSSA---------DPKAPPPPPVSS 338
                   P PP   GP   P           +G    S           P  P  PP   
Sbjct: 433  ----ECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEI 488

Query: 339  GEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGP 398
            G P   G   D           R L           P      G    GPQ  PG++  P
Sbjct: 489  GFPGQPGAKGD-----------RGL-----------PGRDGVAGVP--GPQGTPGLIGQP 524

Query: 399  QKKPEGPIQAMMAQSQSLGKG-------PGPRTDVGAPFGPQGHRDVPF---SPD----- 443
              K E P +          KG       PG     G+P G  GH  +P    SP      
Sbjct: 525  GAKGE-PGEFYFDLRLKGDKGDPGFPGQPGMTGRAGSP-GRDGHPGLPGPKGSPGSVGLK 582

Query: 444  -EMVPPS---MNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQD 499
             E  PP         G  GP       P      K Q  F                    
Sbjct: 583  GERGPPGGVGFPGSRGDTGPPGPPGYGPAGPIGDKGQAGFPGGP---------------- 626

Query: 500  MMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQ 559
                  G  G+      P ++ P  G  P G E        P     RG    P  PG  
Sbjct: 627  ------GSPGLPGPKGEPGKIVPLPG--PPGAEGLPGSPGFPGPQGDRGFPGTPGRPG-- 676

Query: 560  MRLPGFAGMINSEMEG-PNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGR- 617
              LPG  G +     G P  P P    GL G   P   P  P     P   G+    G  
Sbjct: 677  --LPGEKGAVGQPGIGFPGPPGPKGVDGLPGDMGPPGTPGRPGFNGLPGNPGVQGQKGEP 734

Query: 618  GERFPNPQGLSE-EMFQQQLAEK-QLGLP--PGMAMEGIRPSMEMNRMIPGSQRHMEPGN 673
            G   P  +GL           EK  +G+P  PG       P ++  R  PG         
Sbjct: 735  GVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLPGSVG 794

Query: 674  NPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEF----GMVPSGMKGDVNLNVNMGSN 729
            +P  P I   G   P  G  P G+    G   E  F    G+   G KGD          
Sbjct: 795  SPGVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKGD--------KG 846

Query: 730  SQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQ 789
            +Q +P    ++G          PG    LP QQ    +P     + E G+   P  P S 
Sbjct: 847  AQGLPGITGQSGL---------PG----LPGQQGAPGIPGFPGSKGEMGVMGTPGQPGSP 893

Query: 790  GPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDIS 849
            GP    GL        P ++ +    H  P    P  +P        V  GL  KP    
Sbjct: 894  GPVGAPGL--------PGEKGD----HGFPGSSGPRGDPGLKGDKGDV--GLPGKP---- 935

Query: 850  VAGSQVHSPGINPLKSPTMHQVQSPMLG--SPSGNLKSPQTPSQLA--GMLAGPAAAASI 905
                 +    +  +K     Q +   +G     G+   P TP      G    P      
Sbjct: 936  ---GSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGDPGTPGVPGKDGQAGQPGQPGPK 992

Query: 906  KSPPVLGSAAASPVHLKSPSLPAP--SPGWTSSPKPPLQS--PGIPPNHKAPLTMASPAM 961
              P + G+  A       P LP P  S G    P  P +   PGIP    +P        
Sbjct: 993  GDPGISGTPGA-------PGLPGPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLPGDKGA 1045

Query: 962  LGNVESGGPP----------------------PPTASQPASVNIPGSLPSSTPYTMPPEP 999
             G     GPP                      P    +  S+ IPG         MP  P
Sbjct: 1046 KGEKGQAGPPGIGIPGLRGEKGDQGIAGFPGSPGEKGEKGSIGIPG---------MPGSP 1096

Query: 1000 TLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGIN 1059
             L  +P S+          P S  L  +                   LP ++ +PG+   
Sbjct: 1097 GLKGSPGSV--------GYPGSPGLPGEK--------------GDKGLPGLDGIPGVKGE 1134

Query: 1060 TQNPRISGPNPVVPMPTLSPMGMT-QPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNP 1118
               P   GP          P G   +P S      +     P +P  G P  PG      
Sbjct: 1135 AGLPGTPGPT--------GPAGQKGEPGSDGIPGSAGEKGEPGLPGRGFPGFPGAKGDKG 1186

Query: 1119 IMGH----GSQEPPMVP--QGRMGF-----PQGFPPVQSPPQQVPFPHNGPSGGQGSFPG 1167
              G     G    P +P  +G  GF     PQG P +   P        G  G QG  PG
Sbjct: 1187 SKGEVGFPGLAGSPGIPGSKGEQGFMGPPGPQGQPGLPGSPGHATEGPKGDRGPQGQ-PG 1245

Query: 1168 GMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPG 1227
              G PG  P+G P              PG PG P         +P    DP  Q +  PG
Sbjct: 1246 LPGLPG--PMGPPGLPGIDGVKGDKGNPGWPGAP--------GVPGPKGDPGFQGM--PG 1293

Query: 1228 ATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLA 1287
              G P    S+              P G VPG + P+G  PG   ++G  G+Q       
Sbjct: 1294 IGGSPGITGSKG----------DMGPPG-VPGFQGPKGL-PGLQGIKGDQGDQGVPGAKG 1341

Query: 1288 LPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQ-QGMMGPHHRMMSPAQSTMPGQPT 1346
            LPG   PGP G  DI  G  P +PG  P  PP     QG+ GP  +        +PG P 
Sbjct: 1342 LPGP--PGPPGPYDIIKGE-PGLPG--PEGPPGLKGLQGLPGPKGQQGVTGLVGIPGPPG 1396

Query: 1347 LMS---NPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMM 1381
            +      P     M P    GP G    PGP G PG M
Sbjct: 1397 IPGFDGAPGQKGEMGPAGPTGPRGFPGPPGPDGLPGSM 1434



 Score =  103 bits (256), Expect = 2e-21
 Identities = 237/941 (25%), Positives = 302/941 (32%), Gaps = 159/941 (16%)

Query: 546  PRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNF 605
            P G + +P  PG    LPG  G      +GP  P P   PG +G        K   G   
Sbjct: 95   PPGASGYPGNPG----LPGIPGQ-----DGP--PGPPGIPGCNGT-------KGERGPLG 136

Query: 606  PPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGS 665
            PPG   F+G       P  +G   E+         LG  PGM ++G        R  PG 
Sbjct: 137  PPGLPGFAGNPGPPGLPGMKGDPGEI---------LGHVPGMLLKG-------ERGFPGI 180

Query: 666  QRHMEPGNNPIFPRIP-VEGPLSPSRGDFPKGIPPQMGP-GRELEFGMV---PSGMKGDV 720
                 PG  P  P +P ++GP+ P     P G P   GP G + + G+    P G KGD 
Sbjct: 181  -----PGT-PGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPKGDKGDQ 234

Query: 721  NLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEH--PQQEYG 778
             ++   G   Q   Q+  +     E+  K  PG   M    +K  P   G    P ++  
Sbjct: 235  GVSGPPGVPGQAQVQEKGDFATKGEKGQKGEPGFQGMPGVGEKGEPGKPGPRGKPGKDGD 294

Query: 779  MGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQ 838
             G +   P   G     GL   + P G            PP P             P + 
Sbjct: 295  KGEKGS-PGFPGEPGYPGLIGRQGPQGEKGEAG------PPGP-------------PGIV 334

Query: 839  RGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAG 898
             G G  PL          +PG  P   P            P G    P  P      + G
Sbjct: 335  IGTG--PLGEKGERGYPGTPG--PRGEP-----------GPKGFPGLPGQPGPPGLPVPG 379

Query: 899  PAAAASIKSPPVLGSAAASPVHLKSPSLPAPS-----PGWTSSPKPPLQ----------S 943
             A A               P      SLP PS     PG   SP PP Q           
Sbjct: 380  QAGAPGFPGERGEKGDRGFP----GTSLPGPSGRDGLPGPPGSPGPPGQPGYTNGIVECQ 435

Query: 944  PGIPPNHKAPLTMASPAMLGNVESGGP---------------PPPTASQPASVNIPGSLP 988
            PG P +   P     P  +G +   G                PP     P  +  PG   
Sbjct: 436  PGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPG 495

Query: 989  SSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLP 1048
            +     +P    ++  P             P +     +    +    D   P   P  P
Sbjct: 496  AKGDRGLPGRDGVAGVPGP--QGTPGLIGQPGAKGEPGEFYFDLRLKGDKGDPG-FPGQP 552

Query: 1049 SMNNMPGMGINTQNPRISGPNPVVPMPTLS-----PMGMTQPLSHSNQ-MPSPNAVGPNI 1102
             M    G      +P + GP        L      P G+  P S  +   P P   GP  
Sbjct: 553  GMTGRAGSPGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGPAG 612

Query: 1103 P-----PHGVPMGPGLMSHNPIMGHGSQEPPMV-PQGRMGFPQGFPPVQSPPQQVPFPHN 1156
            P       G P GPG        G   +  P+  P G  G P G P    P     FP  
Sbjct: 613  PIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLPGPPGAEGLP-GSPGFPGPQGDRGFPGT 671

Query: 1157 GPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFT 1216
                G     G +G PG G  G P           +  PG PG P    + GN  P V  
Sbjct: 672  PGRPGLPGEKGAVGQPGIGFPGPPGPKGVDGLPGDMGPPGTPGRPGFNGLPGN--PGVQG 729

Query: 1217 DPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGM 1276
                  V  PG  G+P        P EK S  +       VPG     GP PG   ++G 
Sbjct: 730  QKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVP-----GVPGEHGAIGP-PGLQGIRGE 783

Query: 1277 MGEQAPRMGLALPGMGGPGPVGTPDIPLGTAP----SMPGHNPMRP-PAFLQQGMMGPHH 1331
             G       +  PG+ G GP G    P G  P      PG    +  P F    M GP  
Sbjct: 784  PGPPGLPGSVGSPGVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKG 843

Query: 1332 RMMSPA------QSTMPGQPTLMSNPAAAVGMIPG--KDRGPAGLYTHPGPVGSPGMMMS 1383
               +        QS +PG P     P      IPG    +G  G+   PG  GSPG +  
Sbjct: 844  DKGAQGLPGITGQSGLPGLPGQQGAPG-----IPGFPGSKGEMGVMGTPGQPGSPGPV-G 897

Query: 1384 MQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNM 1424
              G+ G + +   P    PRG     G  G    PG PG+M
Sbjct: 898  APGLPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPGKPGSM 938



 Score =  102 bits (254), Expect = 3e-21
 Identities = 319/1296 (24%), Positives = 414/1296 (31%), Gaps = 247/1296 (19%)

Query: 235  PQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPAS 294
            P  PP     +    +   L P P +P  A  P  P  P  +  PG     +P +     
Sbjct: 116  PPGPPGIPGCNGTKGERGPLGP-PGLPGFAGNPGPPGLPGMKGDPGEILGHVPGMLLKGE 174

Query: 295  -STPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQ 353
               P  P   GP   P  +   PV     +    P  PP PP   G+     + P G   
Sbjct: 175  RGFPGIPGTPGPPGLPGLQG--PVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPKGDKG 232

Query: 354  EQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQS 413
            +Q       +     +Q     ++ +F      G +  PG    P    +G         
Sbjct: 233  DQGVSGPPGVPGQAQVQ-----EKGDFATKGEKGQKGEPGFQGMPGVGEKG--------- 278

Query: 414  QSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWL 473
               GK PGPR   G   G +G +  P  P E   P +  + G  G               
Sbjct: 279  -EPGK-PGPRGKPGKD-GDKGEKGSPGFPGEPGYPGLIGRQGPQG--------------- 320

Query: 474  KLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPP-------PYQMTPSEGW 526
                        K E                 GP G+V G  P        Y  TP    
Sbjct: 321  -----------EKGE-------------AGPPGPPGIVIGTGPLGEKGERGYPGTPGPRG 356

Query: 527  APGGTE-PFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPN----VPNP 581
             PG    P   G   P  LP  G A  P  PG +    G  G   + + GP+    +P P
Sbjct: 357  EPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGE-KGDRGFPGTSLPGPSGRDGLPGP 415

Query: 582  ASRPGLSGVSWPDDVPKIPDGRNFPPGQ----GIFSGPG----------RGERF------ 621
               PG  G   P     I + +  PPG     GI   PG          +GE        
Sbjct: 416  PGSPGPPGQ--PGYTNGIVECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDID 473

Query: 622  -----PNPQGLSEEMF--QQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNN 674
                 P PQG   E+    Q  A+   GLP    + G+        +I       EPG  
Sbjct: 474  GYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGPQGTPGLIGQPGAKGEPGEF 533

Query: 675  PIFPRIPVEGPLSPSRGDFPKGIPPQMG-------PGRELEFGMV-PSGMKGDVNLNVNM 726
                R      L   +GD   G P Q G       PGR+   G+  P G  G V L    
Sbjct: 534  YFDLR------LKGDKGD--PGFPGQPGMTGRAGSPGRDGHPGLPGPKGSPGSVGLKGER 585

Query: 727  GSNSQM-IPQKMREAG---------AGP--EEMLKLRPGG--SDMLPAQQ----KMVPLP 768
            G    +  P    + G         AGP  ++     PGG  S  LP  +    K+VPLP
Sbjct: 586  GPPGGVGFPGSRGDTGPPGPPGYGPAGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLP 645

Query: 769  FGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSS-- 826
                P    G+   P  P  QG     G             T  R    P LP    +  
Sbjct: 646  ---GPPGAEGLPGSPGFPGPQGDRGFPG-------------TPGR----PGLPGEKGAVG 685

Query: 827  NPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSP 886
             P      PP  +G+   P D+   G+    PG N L      Q Q    G P   L   
Sbjct: 686  QPGIGFPGPPGPKGVDGLPGDMGPPGTPGR-PGFNGLPGNPGVQGQK---GEPGVGLPGL 741

Query: 887  QTPSQLAGMLAGPAAAASIKSPPVLGS-AAASPVHLKS-PSLPAPS--PGWTSSPKPP-L 941
            +    L G+   P    SI  P V G   A  P  L+     P P   PG   SP  P +
Sbjct: 742  KGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLPGSVGSPGVPGI 801

Query: 942  QSPGI--PPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGS--LPSSTPYTMPP 997
              PG   PP  + P  ++ P  +   E G P  P    P      G+  LP  T  +  P
Sbjct: 802  GPPGARGPPGGQGPPGLSGPPGIKG-EKGFPGFPGLDMPGPKGDKGAQGLPGITGQSGLP 860

Query: 998  EPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSM---NNMP 1054
                 Q    I     SK  M          +           P  +P LP     +  P
Sbjct: 861  GLPGQQGAPGIPGFPGSKGEM---------GVMGTPGQPGSPGPVGAPGLPGEKGDHGFP 911

Query: 1055 GMGINTQNPRISGPNPVVPMP----TLSPMGMTQPLSHSNQMPSPNAVGP--NIPPHGVP 1108
            G      +P + G    V +P    ++  + M               +GP       G P
Sbjct: 912  GSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGDP 971

Query: 1109 MGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGG 1168
              PG+   +   G   Q  P    G  G P G P +  P   V               GG
Sbjct: 972  GTPGVPGKDGQAGQPGQPGPKGDPGISGTP-GAPGLPGPKGSV---------------GG 1015

Query: 1169 MGFPG----EGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVI 1224
            MG PG    +G  G P   PQ S       PG PG   +    G + P     P L+   
Sbjct: 1016 MGLPGTPGEKGVPGIPG--PQGS-------PGLPGDKGAKGEKGQAGPPGIGIPGLRG-- 1064

Query: 1225 RPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRM 1284
              G  GI  F  S     EK S  +   P    PG K   G   G+    G+ GE+  + 
Sbjct: 1065 EKGDQGIAGFPGSPGEKGEKGSIGIPGMPGS--PGLKGSPG-SVGYPGSPGLPGEKGDK- 1120

Query: 1285 GLALPGMGG-PGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPG 1343
               LPG+ G PG  G   +P    P+ P      P +    G  G       P +   PG
Sbjct: 1121 --GLPGLDGIPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAGEKGEPGLPGRG-FPG 1177

Query: 1344 QPTLMSNPAAA--VGM--------IPGKDRGPAGLYTHPGPVGSPGMMMSM-------QG 1386
             P    +  +   VG         IPG  +G  G    PGP G PG+  S        +G
Sbjct: 1178 FPGAKGDKGSKGEVGFPGLAGSPGIPGS-KGEQGFMGPPGPQGQPGLPGSPGHATEGPKG 1236

Query: 1387 MMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
              GPQ    +P    P G     G+ G     GNPG
Sbjct: 1237 DRGPQGQPGLPGLPGPMGPPGLPGIDGVKGDKGNPG 1272



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 260/1044 (24%), Positives = 325/1044 (31%), Gaps = 210/1044 (20%)

Query: 513  GPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAG----- 567
            GPP P  +    G   G   P       P  LP  G A +P  PG    LPG  G     
Sbjct: 115  GPPGPPGIPGCNG-TKGERGPLG-----PPGLP--GFAGNPGPPG----LPGMKGDPGEI 162

Query: 568  -------MINSEMEGPNVPN---PASRPGLSGVSWPDDV--PKIPDGRNFPPGQ----GI 611
                   ++  E   P +P    P   PGL G   P     P  P G   PPG+    G+
Sbjct: 163  LGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGL 222

Query: 612  -FSGPGRGERFPNPQGLSEEMFQQQLAEK----------QLGLPPGMAMEGI----RPSM 656
             F GP   +      G      Q Q+ EK          Q G P    M G+     P  
Sbjct: 223  SFQGPKGDKGDQGVSGPPGVPGQAQVQEKGDFATKGEKGQKGEPGFQGMPGVGEKGEPGK 282

Query: 657  EMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRE--LEFGMVPS 714
               R  PG         +P FP  P    L   +G  P+G   + GP     +  G  P 
Sbjct: 283  PGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQG--PQGEKGEAGPPGPPGIVIGTGPL 340

Query: 715  GMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQ 774
            G KG+       G           E G      L  +PG   +    Q   P   GE  +
Sbjct: 341  GEKGERGYPGTPGPRG--------EPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGE 392

Query: 775  QEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTA 834
            +     P   LP   G     G      P G    TN  +   P  P      P  +   
Sbjct: 393  KGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNGIVECQPGPP--GDQGPPGIPGQ 450

Query: 835  PPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPS-------------- 880
            P     +G K       G       I+  + P   Q     +G P               
Sbjct: 451  PGFIGEIGEK----GQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRD 506

Query: 881  --GNLKSPQTPSQLAGM---------------LAGPAAAASIKSPPVLGSAAASPVHLKS 923
                +  PQ    L G                L G          P +   A SP     
Sbjct: 507  GVAGVPGPQGTPGLIGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMTGRAGSPGRDGH 566

Query: 924  PSLPAP-----------------------SPGWTSSPKPPLQSPGIPPNHKA----PLTM 956
            P LP P                       S G T  P PP   P  P   K     P   
Sbjct: 567  PGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGPAGPIGDKGQAGFPGGP 626

Query: 957  ASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKF 1016
             SP + G     G   P    P +  +PGS     P      P     P   +       
Sbjct: 627  GSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPGFPGPQGDRGFPGTPGRP--GLPGEKGAV 684

Query: 1017 AMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGP--NPVVPM 1074
              P          K V     D  P  +P  P  N +PG      NP + G    P V +
Sbjct: 685  GQPGIGFPGPPGPKGVDGLPGDMGPPGTPGRPGFNGLPG------NPGVQGQKGEPGVGL 738

Query: 1075 PTLSPMGMTQPLSHSNQMPSPNAVG-PNIP-PHGVPMGPGLMSHNPIMGHGSQEPPMVPQ 1132
            P L   G+              ++G P +P  HG    PGL         G   PP +P 
Sbjct: 739  PGLK--GLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGI-----RGEPGPPGLP- 790

Query: 1133 GRMGFPQGFPPVQSPPQQVPFPHNGPSG--------GQGSFPG--GMGFPG----EGPLG 1178
            G +G P G P +  P  + P    GP G        G+  FPG  G+  PG    +G  G
Sbjct: 791  GSVGSP-GVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKGDKGAQG 849

Query: 1179 RPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSR 1238
             P    QS       + G PG P  F      M  + T         PG  G P    + 
Sbjct: 850  LPGITGQSGLPGLPGQQGAPGIP-GFPGSKGEMGVMGT---------PGQPGSPGPVGAP 899

Query: 1239 IIPSEKPSQTL--QYFPRGEVPGRKQPQG----PG-PG------FSHMQGMMGEQAPRMG 1285
             +P EK          PRG+ PG K  +G    PG PG         M+G  G+Q  +  
Sbjct: 900  GLPGEKGDHGFPGSSGPRGD-PGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQ 958

Query: 1286 LALPG-MGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQ 1344
            +   G  G  G  GTP +P     +             Q G  GP      P  S  PG 
Sbjct: 959  IGPIGEKGSRGDPGTPGVPGKDGQAG------------QPGQPGPKG---DPGISGTPGA 1003

Query: 1345 PTLMSNPAAAVGM-IPGKDRGPAGLYTHPGPVGSPGM-----MMSMQGMMGPQQNIMIPP 1398
            P L     +  GM +PG   G  G+   PGP GSPG+         +G  GP   I IP 
Sbjct: 1004 PGLPGPKGSVGGMGLPGTP-GEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGP-PGIGIPG 1061

Query: 1399 QMRPRGMAADVGMGGFSQGPGNPG 1422
                RG   D G+ GF   PG  G
Sbjct: 1062 L---RGEKGDQGIAGFPGSPGEKG 1082



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 98/346 (28%), Positives = 122/346 (35%), Gaps = 83/346 (23%)

Query: 1132 QGRMGFP--QGFPPVQSPPQQ--------VPFPHN--GPSGGQG--SFPGGMGFPG-EGP 1176
            QG +GFP  QG    Q PP Q        +P      GP G  G    PG  G PG +GP
Sbjct: 57   QGVIGFPGMQGPEGPQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLPGIPGQDGP 116

Query: 1177 LGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDL 1236
             G P  +P  +       P GP G   F   GN  P     P L     PG  G P   L
Sbjct: 117  PG-PPGIPGCNGTKGERGPLGPPGLPGFA--GNPGP-----PGL-----PGMKGDPGEIL 163

Query: 1237 SRI----IPSEKPSQTLQYFPRGE-VPGRKQPQGPGPGFSHMQGMMGEQAP-----RMGL 1286
              +    +  E+    +   P    +PG + P GP PGF+   G  G   P     +MGL
Sbjct: 164  GHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGP-PGFTGPPGPPGPPGPPGEKGQMGL 222

Query: 1287 ALPG----MGGPGPVGTPDIPLGTA----------------------PSMPG----HNPM 1316
            +  G     G  G  G P +P G A                        MPG      P 
Sbjct: 223  SFQGPKGDKGDQGVSGPPGVP-GQAQVQEKGDFATKGEKGQKGEPGFQGMPGVGEKGEPG 281

Query: 1317 RPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVG 1376
            +P    + G  G      SP     PG P L+              +GP G     GP G
Sbjct: 282  KPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGR------------QGPQGEKGEAGPPG 329

Query: 1377 SPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
             PG+++   G +G +     P    PRG     G  G    PG PG
Sbjct: 330  PPGIVIG-TGPLGEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPG 374



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 56/192 (29%), Positives = 72/192 (37%), Gaps = 49/192 (25%)

Query: 1265 GPGPGFSHMQGMMGEQAPRMGL-------ALPGMGGP-GPVGTPDIPLGTA-PSMPGHNP 1315
            G G G     G+ G++  R GL         PGM GP GP G P     T  P +PG   
Sbjct: 33   GSGCGKCDCHGVKGQKGER-GLPGLQGVIGFPGMQGPEGPQGPPGQKGDTGEPGLPG--- 88

Query: 1316 MRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPG-----KDRGPAG--- 1367
                    +G  GP      P    +PG P     P    G IPG      +RGP G   
Sbjct: 89   -------TKGTRGPPGASGYPGNPGLPGIPG-QDGPPGPPG-IPGCNGTKGERGPLGPPG 139

Query: 1368 ---LYTHPGPVGSPGMMMSMQGMMGPQQNIMI--------------PPQMRPRGMAADVG 1410
                  +PGP G PGM      ++G    +++              PP +   G+   VG
Sbjct: 140  LPGFAGNPGPPGLPGMKGDPGEILGHVPGMLLKGERGFPGIPGTPGPPGL--PGLQGPVG 197

Query: 1411 MGGFSQGPGNPG 1422
              GF+  PG PG
Sbjct: 198  PPGFTGPPGPPG 209



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 148/641 (23%), Positives = 201/641 (31%), Gaps = 132/641 (20%)

Query: 21   KSKQEVMVRP--PTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPG 78
            K +  VM  P  P    P G P L  +  + G  G S  +  P       G      LPG
Sbjct: 878  KGEMGVMGTPGQPGSPGPVGAPGLPGEKGDHGFPGSSGPRGDPG----LKGDKGDVGLPG 933

Query: 79   PGGSMG-LKNGAGNGAKGKGKRERSIS--ADSFDQRDPGTPNDDSDIKECNSADHIKSQD 135
              GSM  +  G+  G KG    +  I    +   + DPGTP              +  +D
Sbjct: 934  KPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGDPGTPG-------------VPGKD 980

Query: 136  SQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKG 195
             Q               S TP            A   P     V    +     E  + G
Sbjct: 981  GQAGQPGQPGPKGDPGISGTPG-----------APGLPGPKGSVGGMGLPGTPGEKGVPG 1029

Query: 196  QVETIVSFHIQNISNNKTERSTA-PLNTQISALRNDP--KPLPQQPPAPANQDQNSSQNT 252
                  S  +      K E+  A P    I  LR +   + +   P +P  + +  S   
Sbjct: 1030 IPGPQGSPGLPGDKGAKGEKGQAGPPGIGIPGLRGEKGDQGIAGFPGSPGEKGEKGSIGI 1089

Query: 253  RLQPTPPIPAPAP-------KPAAPPRPLDRESPGVENKLIPSVGSPAS--STPLPPDGT 303
               P  P    +P        P  P    D+  PG++   IP V   A    TP P    
Sbjct: 1090 PGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDG--IPGVKGEAGLPGTPGPTGPA 1147

Query: 304  GPNSTPNNRAVTPVSQGSNSSSADPKAP----PPPPVSSGEPPTLGE-NPDGLSQEQLEH 358
            G    P +  +     GS     +P  P    P  P + G+  + GE    GL+      
Sbjct: 1148 GQKGEPGSDGIP----GSAGEKGEPGLPGRGFPGFPGAKGDKGSKGEVGFPGLAGSPGIP 1203

Query: 359  RERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGK 418
              +               E+ F G    GPQ  PG+   P    EGP      Q Q    
Sbjct: 1204 GSKG--------------EQGFMGPP--GPQGQPGLPGSPGHATEGPKGDRGPQGQPGLP 1247

Query: 419  G-PGPRTDVGAPF-----GPQGHRDVPFSPDEMVP---------------PSMNSQSGTI 457
            G PGP    G P      G +G+   P +P    P               P +    G +
Sbjct: 1248 GLPGPMGPPGLPGIDGVKGDKGNPGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDM 1307

Query: 458  GPDHLDHMT-PEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPP 516
            GP  +     P+ +  L+        K  + +Q V     L        GP G    PP 
Sbjct: 1308 GPPGVPGFQGPKGLPGLQ------GIKGDQGDQGVPGAKGLP-------GPPG----PPG 1350

Query: 517  PYQMTPSEGWAPGGTEPFSDGINMPHSLP-PR------GMAPHPNMPGSQMRLPGFAGMI 569
            PY +   E   PG   P   G+     LP P+      G+   P  PG    +PGF G  
Sbjct: 1351 PYDIIKGEPGLPGPEGP--PGLKGLQGLPGPKGQQGVTGLVGIPGPPG----IPGFDGAP 1404

Query: 570  NSEME-GP-------NVPNPASRPGLSGVSWPDDVPKIPDG 602
              + E GP         P P    GL G   P   P +  G
Sbjct: 1405 GQKGEMGPAGPTGPRGFPGPPGPDGLPGSMGPPGTPSVDHG 1445



 Score = 34.7 bits (78), Expect = 0.67
 Identities = 34/124 (27%), Positives = 47/124 (37%), Gaps = 21/124 (16%)

Query: 6    PKVRSSPSGNTQSSPKSKQEVMVRP-----PTVMSPSGNPQLDSKFSNQGKQGGSASQSQ 60
            P +  SP G+    PK  +    +P     P  M P G P +D    ++G  G   +   
Sbjct: 1221 PGLPGSP-GHATEGPKGDRGPQGQPGLPGLPGPMGPPGLPGIDGVKGDKGNPGWPGAPGV 1279

Query: 61   PSPCDSKSGGHTPKALPGPGGSMGLKNGAGN----------GAKGKGKRERSISADSFDQ 110
            P P     G    + +PG GGS G+    G+          G KG    +  I  D  DQ
Sbjct: 1280 PGP----KGDPGFQGMPGIGGSPGITGSKGDMGPPGVPGFQGPKGLPGLQ-GIKGDQGDQ 1334

Query: 111  RDPG 114
              PG
Sbjct: 1335 GVPG 1338


>gi|89142737 alpha 3 type IV collagen isoform 5 precursor [Homo
            sapiens]
          Length = 1424

 Score =  113 bits (283), Expect = 1e-24
 Identities = 249/963 (25%), Positives = 327/963 (33%), Gaps = 250/963 (25%)

Query: 506  GPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGF 565
            G +GV   P PP +  P    +     P   G        P G   HP   G     PG 
Sbjct: 628  GTQGVPGAPGPPGEAGPRGELSVSTPVPGPPG--------PPGPPGHPGPQGP----PGI 675

Query: 566  AGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDG-RNFPPGQGIFSGPGR-GER-FP 622
             G +  +   P +P P   PG+ G+ +P   P  P G + FP  +G    PG+ GE   P
Sbjct: 676  PGSLG-KCGDPGLPGPDGEPGIPGIGFPG--PPGPKGDQGFPGTKGSLGCPGKMGEPGLP 732

Query: 623  NPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPG--NNPIFPRI 680
               GL          E  + +P G    G  P    N     S  H E G    P  P  
Sbjct: 733  GKPGLPGAK-----GEPAVAMPGGPGTPGF-PGERGN-----SGEHGEIGLPGLPGLPGT 781

Query: 681  PVEGPLSPSRGDFPKGIPP--QMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMR 738
            P    L   RGD  +  PP  Q  PGR +E    P G +G   LN   G       Q+ R
Sbjct: 782  PGNEGLDGPRGDPGQPGPPGEQGPPGRCIEG---PRGAQGLPGLNGLKG-------QQGR 831

Query: 739  EAGAGPEEMLKLR-------PG--GSDMLPAQQ-KMVPLPFGEHPQQEYGMGPRPFLPMS 788
                GP+    +        PG  GS  +P  Q +M PL    +P     +GP       
Sbjct: 832  RGKTGPKGDPGIPGLDRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNPGILGP------- 884

Query: 789  QGPGSNS--GLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPL 846
              PG +   G+      IGP           P  P NP +         P QRG      
Sbjct: 885  --PGEDGVIGMMGFPGAIGP-----------PGPPGNPGT---------PGQRG------ 916

Query: 847  DISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIK 906
                      SPGI  +K     Q  +P      G+  +P  PS+++ ++         K
Sbjct: 917  ----------SPGIPGVKG----QRGTPGAKGEQGDKGNPG-PSEISHVIGD-------K 954

Query: 907  SPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVE 966
              P L   A +P    +  +P                PG+      P     P   G++ 
Sbjct: 955  GEPGLKGFAGNPGEKGNRGVPG--------------MPGLKGLKGLPGPAGPPGPRGDLG 1000

Query: 967  SGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYH 1026
            S G P     +P    IPGS                          M    MP S     
Sbjct: 1001 STGNP----GEPGLRGIPGS--------------------------MGNMGMPGS----- 1025

Query: 1027 DAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRIS-GPNPVVPMPTLSPMGMTQP 1085
               K    +      A  P LP ++ + G   +   P  S G  P  P PT  P G+   
Sbjct: 1026 ---KGKRGTLGFPGRAGRPGLPGIHGLQG---DKGEPGYSEGTRPGPPGPTGDP-GLPGD 1078

Query: 1086 LSHSNQMPSPNAVGPNIP--PHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQ---- 1139
            +    +M  P   G   P  P G P  PG          G    P  P G +GF      
Sbjct: 1079 MGKKGEMGQPGPPGHLGPAGPEGAPGSPG--------SPGLPGKPG-PHGDLGFKGIKGL 1129

Query: 1140 -GFPPVQSPPQQVPFPHN-GPSG-----GQGSFPGGMGFPGEGPLGRPSNLPQSSADAAL 1192
             G P ++ PP    FP + GP G     G+   PG  G  GE  L R    P+ +  A  
Sbjct: 1130 LGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQG 1189

Query: 1193 CK-----PGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEK-PS 1246
             K     PG PG P     +G++ P              G TGI  F     +P    P 
Sbjct: 1190 AKGDRGAPGFPGLPGRKGAMGDAGPR-------------GPTGIEGFPGPPGLPGAIIPG 1236

Query: 1247 QTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGT 1306
            QT    P G       P  PGP  SH+ G+ G++          MG PGP G P    GT
Sbjct: 1237 QTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKG--------SMGHPGPKGPP----GT 1284

Query: 1307 APSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPG---QPTLMSNPAAAVGMIPGKDR 1363
            A                 G MGP  R+ +P    +PG    P     P      + G+  
Sbjct: 1285 A-----------------GDMGPPGRLGAPGTPGLPGPRGDPGFQGFPG-----VKGEKG 1322

Query: 1364 GPA--GLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNP 1421
             P   G    PGP+G  G    ++G  G  + I +P    P G   + GM G    PG P
Sbjct: 1323 NPGFLGSIGPPGPIGPKGPP-GVRGDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPPGPP 1381

Query: 1422 GNM 1424
            GN+
Sbjct: 1382 GNL 1384



 Score =  110 bits (276), Expect = 7e-24
 Identities = 251/990 (25%), Positives = 332/990 (33%), Gaps = 199/990 (20%)

Query: 516  PPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGS--QMRLPGFAGMINSE- 572
            P +  +P     PG T P+   + +P     +G    P +PG+     +PG AG+   + 
Sbjct: 99   PGFSGSPGLPGTPGNTGPYGL-VGVPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKG 157

Query: 573  ---MEGPNVPNPASRPGLSGVSWPDDVPKIPD--GRNFPPGQ-GIFSGPGR-GERFPNPQ 625
                E     +    PGL G   P  +P  P   G   PPG  G F  PG  G R P   
Sbjct: 158  APAKEEDIELDAKGDPGLPGAPGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGP--- 214

Query: 626  GLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGP 685
                   +  + E+ +G      ++G+                  P   P    + + GP
Sbjct: 215  -------KGHMGERVIGHKGERGVKGLTG----------------PPGPPGTVIVTLTGP 251

Query: 686  -----LSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNS--------QM 732
                 L   +GD  KG   + GP         PSG+ G+     + GS          Q 
Sbjct: 252  DNRTDLKGEKGD--KGAMGEPGPPG-------PSGLPGE-----SYGSEKGAPGDPGLQG 297

Query: 733  IPQKMREAGAGPEEMLKLRPG-----GSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPM 787
             P K    G    E +K   G     G D +  Q+  +  P    P + Y          
Sbjct: 298  KPGKDGVPGFPGSEGVKGNRGFPGLMGEDGIKGQKGDIGPPGFRGPTEYYDTYQEKGDEG 357

Query: 788  SQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLD 847
            + GP    G R  + P GP           P +P +P S+   L  AP      G K   
Sbjct: 358  TPGPPGPRGARGPQGPSGP-----------PGVPGSPGSSRPGLRGAPGWPGLKGSK--- 403

Query: 848  ISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKS 907
                  +   PG + + +P          GSP G   SP  P    G    P      K 
Sbjct: 404  -----GERGRPGKDAMGTP----------GSP-GCAGSPGLPGS-PGPPGPPGDIVFRKG 446

Query: 908  PPVLGSAAASPVHLKSPSLPAPS-----PGWTSSPKPPLQSP-------------GIPPN 949
            PP        P +L SP +P        PG   +  P +  P             GIP  
Sbjct: 447  PP---GDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGLPGLHGVKGIPGR 503

Query: 950  HKAPLTMASPAMLGNVESGGPP--PPTASQPASVNIPG-SLPSSTPYTMPPEPTLSQNPL 1006
              A     SP   GN    G P  P     P      G +L       +P +P L   P 
Sbjct: 504  QGAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQPEGQVGVPGDPGLRGQPG 563

Query: 1007 SIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPAR-----SPNLPSMNNMPGMGINTQ 1061
               +  +         P     +       D  PP       SP        PG G   +
Sbjct: 564  RKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGSPGPAGPAGPPGYGPQGE 623

Query: 1062 NPRISGPNPVVPMPTLSPMGMTQPLSH-SNQMPSPNAVGPNIPP-HGVPMGPGLMSHNPI 1119
             P + G   V   P   P G   P    S   P P   GP  PP H  P GP  +  +  
Sbjct: 624  -PGLQGTQGVPGAP--GPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGS-- 678

Query: 1120 MGHGSQEPPMVPQGRMGFPQ-GFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLG 1178
            +G         P G  G P  GFP    P     FP  G  G  G  PG MG PG    G
Sbjct: 679  LGKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGFP--GTKGSLGC-PGKMGEPGLP--G 733

Query: 1179 RPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIP------ 1232
            +P  LP +  + A+  PGGPG P      GNS        +  E+  PG  G+P      
Sbjct: 734  KPG-LPGAKGEPAVAMPGGPGTPGFPGERGNS-------GEHGEIGLPGLPGLPGTPGNE 785

Query: 1233 EFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQG-PG-PGFSHMQGMMGEQAPRMGLALPG 1290
              D  R  P +      Q  P   + G +  QG PG  G    QG  G+  P+    +PG
Sbjct: 786  GLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPG 845

Query: 1291 M---GGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTL 1347
            +   G PG  G+P I        PGH          QG MGP        Q   PG P +
Sbjct: 846  LDRSGFPGETGSPGI--------PGH----------QGEMGP------LGQRGYPGNPGI 881

Query: 1348 MSNPA--AAVGMI--PGK--DRGPAGLYTHPGPVGSPGM--------MMSMQGMMGPQQN 1393
            +  P     +GM+  PG     GP G    PG  GSPG+            +G  G + N
Sbjct: 882  LGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGN 941

Query: 1394 IMIPPQMRPRGMAADVGMGGFSQGPGNPGN 1423
                      G   + G+ GF+  PG  GN
Sbjct: 942  PGPSEISHVIGDKGEPGLKGFAGNPGEKGN 971



 Score =  107 bits (267), Expect = 8e-23
 Identities = 309/1274 (24%), Positives = 408/1274 (32%), Gaps = 241/1274 (18%)

Query: 290  GSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLG-ENP 348
            G+PA    +  D  G    P   A  P           P  PP PP   G P  +G   P
Sbjct: 157  GAPAKEEDIELDAKGDPGLPG--APGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGP 214

Query: 349  DG-LSQEQLEHR-ERSLQTLRD--------IQRMLFPDEKEFTGAQSG-----------G 387
             G + +  + H+ ER ++ L          I  +  PD +     + G           G
Sbjct: 215  KGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGEKGDKGAMGEPGPPG 274

Query: 388  PQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVP 447
            P   PG   G +K   G           L   PG     G P G +G +     P  M  
Sbjct: 275  PSGLPGESYGSEKGAPG--------DPGLQGKPGKDGVPGFP-GSEGVKGNRGFPGLMGE 325

Query: 448  PSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGP 507
              +  Q G IGP      T           E+Y+  + K ++        +     Q GP
Sbjct: 326  DGIKGQKGDIGPPGFRGPT-----------EYYDTYQEKGDEGTPGPPGPRGARGPQ-GP 373

Query: 508  RGVVRGPPPPYQMTPSEGWAPGGT----------EPFSDGINMPHSLPPRGMAPHPNMPG 557
             G    P  P    P    APG             P  D +  P S    G A  P +PG
Sbjct: 374  SGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGS---PGCAGSPGLPG 430

Query: 558  S------------------QMRLPGFAGMINSE-MEGPN------------VPNPASRPG 586
            S                     LPG+ G      ++GP             +P P   PG
Sbjct: 431  SPGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPG 490

Query: 587  LSGVSWPDDVPK------IPDGRNFPPGQGIFSGPGRGERFPNPQG---LSEEMFQQQLA 637
            L G+     +P       +      P   G+   PG    FP  QG   L  E  +    
Sbjct: 491  LPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPG----FPGAQGDPGLKGEKGETLQP 546

Query: 638  EKQLGLP--PGM-------AMEGIR--------PSMEMNRMIPGSQRHMEPGNNPIFPRI 680
            E Q+G+P  PG+        ++GI         P  +    + G +    P  +P  P  
Sbjct: 547  EGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGS 606

Query: 681  PVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREA 740
            P  GP  P+    P G  PQ  PG +   G+   G  G        G  S   P      
Sbjct: 607  P--GPAGPAG---PPGYGPQGEPGLQGTQGV--PGAPGPPGEAGPRGELSVSTPVPGPPG 659

Query: 741  GAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNL 800
              GP       P G   +P        P    P  E G+ P    P   GP  + G    
Sbjct: 660  PPGPPG--HPGPQGPPGIPGSLGKCGDPGLPGPDGEPGI-PGIGFPGPPGPKGDQGFPGT 716

Query: 801  REPIG-PDQRTNSRLSHMPPLPLNPSSNPTSLNTAP-----PVQRGLGRKPLDISVAG-- 852
            +  +G P +     L   P LP        ++   P     P +RG   +  +I + G  
Sbjct: 717  KGSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLP 776

Query: 853  SQVHSPGINPLKSPTMHQVQSPMLGS---PSGNLKSPQTPSQLAGMLA-----GPAAAAS 904
                +PG   L  P     Q    G    P   ++ P+    L G+       G      
Sbjct: 777  GLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTG 836

Query: 905  IKSPPVLGSAAAS--PVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPA-- 960
             K  P +     S  P    SP +P            PL   G P N   P  +  P   
Sbjct: 837  PKGDPGIPGLDRSGFPGETGSPGIPGHQ-----GEMGPLGQRGYPGN---PGILGPPGED 888

Query: 961  ----MLGNVESGGPPPP-----TASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMS 1011
                M+G   + GPP P     T  Q  S  IPG            E     NP     S
Sbjct: 889  GVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPGP---S 945

Query: 1012 RMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGP--- 1068
             +S        P     +K  A +  +      P +P +  + G+      P   G    
Sbjct: 946  EISHVIGDKGEP----GLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGPPGPRGDLGS 1001

Query: 1069 --NPVVP----MP-TLSPMGMTQPLSHSNQMPSPNAVG-PNIPP-HGVPMGPGLMSHNPI 1119
              NP  P    +P ++  MGM         +  P   G P +P  HG+    G     P 
Sbjct: 1002 TGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGIHGLQGDKG----EPG 1057

Query: 1120 MGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPG-EGPLG 1178
               G++  P  P G  G P          Q  P  H GP+G +G+ PG  G PG  G  G
Sbjct: 1058 YSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGA-PGSPGSPGLPGKPG 1116

Query: 1179 RPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIP-EFDLS 1237
               +L        L  PG  G P      G+  P        ++ I PG  G   E  L 
Sbjct: 1117 PHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGI-PGPAGEKGETGLL 1175

Query: 1238 RIIPSEKPSQTLQYFPRGEVPGRKQPQG----PG-PGFSHMQGMMGEQAPRMGLALPGMG 1292
            R  P           PRG  PG +  +G    PG PG    +G MG+  PR    + G  
Sbjct: 1176 RAPPG----------PRGN-PGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEGF- 1223

Query: 1293 GPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPA 1352
             PGP G P         +PG          Q G  GP      P     PG P     P 
Sbjct: 1224 -PGPPGLP------GAIIPG----------QTGNRGP------PGSRGSPGAPGPPGPPG 1260

Query: 1353 AAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMG 1412
            + V  I G D+G  G   HPGP G PG      G MGP   +  P      G   D G  
Sbjct: 1261 SHVIGIKG-DKGSMG---HPGPKGPPGTA----GDMGPPGRLGAPGTPGLPGPRGDPGFQ 1312

Query: 1413 GFSQGPGNPGNMMF 1426
            GF    G  GN  F
Sbjct: 1313 GFPGVKGEKGNPGF 1326



 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 192/808 (23%), Positives = 260/808 (32%), Gaps = 162/808 (20%)

Query: 254  LQPTPPIPAPAPKPAAPPRPLDRESPGVENKL-------IP----SVGSPASSTPLPPDG 302
            L  + P+P P   P  P  P  +  PG+   L       +P      G P    P PP  
Sbjct: 648  LSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFPGPPGP 707

Query: 303  TGPNSTPNNRAVTPVSQGSNSSSADPKAPPPP--PVSSGEPPTL---GENPDGLSQEQLE 357
             G    P  +     S G      +P  P  P  P + GEP      G    G   E+  
Sbjct: 708  KGDQGFPGTKG----SLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGN 763

Query: 358  HRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQ--NPGVLDGPQKKPEGP--------IQ 407
              E     L  +  +      E      G P Q   PG    P +  EGP        + 
Sbjct: 764  SGEHGEIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLN 823

Query: 408  AMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTP 467
             +  Q    GK  GP+ D G P       D    P E   P +    G +GP        
Sbjct: 824  GLKGQQGRRGK-TGPKGDPGIP-----GLDRSGFPGETGSPGIPGHQGEMGP-------- 869

Query: 468  EQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM-TPSEGW 526
                   L Q  Y           +     +D ++   G  G +  P PP    TP +  
Sbjct: 870  -------LGQRGYPGNPG------ILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRG 916

Query: 527  APG-----------------------GTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLP 563
            +PG                       G    S  I        +G A +P   G++  +P
Sbjct: 917  SPGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNR-GVP 975

Query: 564  GFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFP--------PG----QGI 611
            G  G+   +     +P PA  PG  G       P  P  R  P        PG    +G 
Sbjct: 976  GMPGLKGLK----GLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGT 1031

Query: 612  FSGPGRGER--FPNPQGLSEEMFQQQLAEKQLGLPPGMAME-GIRPSM----EMNRMIPG 664
               PGR  R   P   GL  +  +   +E     PPG   + G+   M    EM +  PG
Sbjct: 1032 LGFPGRAGRPGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQ--PG 1089

Query: 665  SQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMV-----PSGMKGD 719
               H+ P         P   P SP       G+P + GP  +L F  +     P G++G 
Sbjct: 1090 PPGHLGPAG-------PEGAPGSPG----SPGLPGKPGPHGDLGFKGIKGLLGPPGIRGP 1138

Query: 720  VNLNVNMGSNSQM--IPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEY 777
              L    GS   M     + R+   GP        G + +L A       P  +  + + 
Sbjct: 1139 PGLPGFPGSPGPMGIRGDQGRDGIPGPAG----EKGETGLLRAPPGPRGNPGAQGAKGDR 1194

Query: 778  GMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSS--NPTSLNTAP 835
            G    P LP  +G   ++G      P GP     + +   P  P  P +     + N  P
Sbjct: 1195 GAPGFPGLPGRKGAMGDAG------PRGP-----TGIEGFPGPPGLPGAIIPGQTGNRGP 1243

Query: 836  PVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGS-----PSGNLKSPQTPS 890
            P  RG    P      GS  H  GI   K    H       G+     P G L +P TP 
Sbjct: 1244 PGSRGSPGAPGPPGPPGS--HVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLGAPGTPG 1301

Query: 891  QLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAP-----SPGWTSSPKPPLQSPG 945
                 L GP      +  P +     +P  L S   P P      PG    P   L+   
Sbjct: 1302 -----LPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRGDP-GTLKIIS 1355

Query: 946  IPPNHKAPLTMASPAMLGNVESGGPPPP 973
            +P +   P T   P M G  E G P PP
Sbjct: 1356 LPGSPGPPGTPGEPGMQG--EPGPPGPP 1381



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 236/982 (24%), Positives = 304/982 (30%), Gaps = 209/982 (21%)

Query: 260  IPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPV-- 317
            +P P  + A      D+  PG       S GSP  + P  P G GP   P  +    V  
Sbjct: 579  LPGPKGELALSGEKGDQGPPGDPG----SPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPG 634

Query: 318  ---------SQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRD 368
                      +G  S S     PP PP   G P   G  P G+     +  +  L     
Sbjct: 635  APGPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQG--PPGIPGSLGKCGDPGLPG--- 689

Query: 369  IQRMLFPD-EKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKG--PGPRTD 425
                  PD E    G    GP    G    P  K        M +    GK   PG + +
Sbjct: 690  ------PDGEPGIPGIGFPGPPGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGE 743

Query: 426  --VGAPFGP-----QGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHM-----TPEQIAWL 473
              V  P GP      G R       E+  P +    GT G + LD        P      
Sbjct: 744  PAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQ 803

Query: 474  KLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEP 533
                   E  R  Q    +     Q     + GP+G    P       P E  +PG   P
Sbjct: 804  GPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGSPG--IP 861

Query: 534  FSDGINMPHSLPPRGMAPHPNMPG--------SQMRLPGFAGMINSEMEGPNVPNPASRP 585
               G      + P G   +P  PG          + + GF G I     GP  P P   P
Sbjct: 862  GHQG-----EMGPLGQRGYPGNPGILGPPGEDGVIGMMGFPGAI-----GP--PGPPGNP 909

Query: 586  GLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPP 645
            G  G      +P +   R  P  +G     G     P P  +S  +  +          P
Sbjct: 910  GTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGN----PGPSEISHVIGDKG--------EP 957

Query: 646  GMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGR 705
            G+      P  + NR +PG      PG   +                  KG+P   G   
Sbjct: 958  GLKGFAGNPGEKGNRGVPGM-----PGLKGL------------------KGLPGPAG--- 991

Query: 706  ELEFGMVPSGMKGDVNLNVNMGS-NSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKM 764
                   P G +GD+    N G    + IP  M   G    +  +    G+   P +   
Sbjct: 992  -------PPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKR----GTLGFPGRAGR 1040

Query: 765  VPLP-----FGEHPQQEYGMGPRPFLPMSQG----PGSNSGLRNLREPIGPDQRTNSRLS 815
              LP      G+  +  Y  G RP  P   G    PG       + +P GP         
Sbjct: 1041 PGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQP-GPPGHLG---- 1095

Query: 816  HMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPM 875
                 P  P   P S     P   GL  KP      G +    GI  L  P       P 
Sbjct: 1096 -----PAGPEGAPGS-----PGSPGLPGKPGPHGDLGFK----GIKGLLGP-------PG 1134

Query: 876  LGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTS 935
            +  P G    P +P  +   + G      I  P   G    + + L++P  P  +PG   
Sbjct: 1135 IRGPPGLPGFPGSPGPMG--IRGDQGRDGIPGP--AGEKGETGL-LRAPPGPRGNPG-AQ 1188

Query: 936  SPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQ--PASVNIPGS-LPSSTP 992
              K    +PG P           P   G +   GP  PT  +  P    +PG+ +P  T 
Sbjct: 1189 GAKGDRGAPGFP---------GLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGAIIPGQTG 1239

Query: 993  YTMPPEPTLSQNPLSIMMSRMSKFAM-PSSTPLYH-DAIKTVASSDDDSPPARSPNLPSM 1050
               PP             SR S  A  P   P  H   IK    S     P   P     
Sbjct: 1240 NRGPPG------------SRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGD 1287

Query: 1051 NNMPGMGINTQNPRISGP-NPVVPMPTLSP--------MGMTQPLSHSNQMPSPNAVGPN 1101
               PG        R+  P  P +P P   P         G          +  P  +GP 
Sbjct: 1288 MGPPG--------RLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPK 1339

Query: 1102 IPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGG 1161
             PP GV   PG +    I   GS  PP  P G  G  QG P    PP  +     GP G 
Sbjct: 1340 GPP-GVRGDPGTL--KIISLPGSPGPPGTP-GEPGM-QGEPGPPGPPGNL-----GPCGP 1389

Query: 1162 QGSFPGGMGFPG-EGPLGRPSN 1182
            +G  PG  G PG  GP G   N
Sbjct: 1390 RGK-PGKDGKPGTPGPAGEKGN 1410



 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 80/277 (28%), Positives = 103/277 (37%), Gaps = 46/277 (16%)

Query: 1161 GQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLG-NSMPSVFTDPD 1219
            G+  FPG  G PG+     P  LP          PG PG   S  V G + +P     P 
Sbjct: 49   GEKGFPGPPGSPGQKGFTGPEGLPGPQGPKGF--PGLPGLTGSKGVRGISGLPGFSGSPG 106

Query: 1220 LQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGE 1279
            L     PG TG   + L   +P    S+  Q FP   +PG     G  PG + ++G  G 
Sbjct: 107  LPGT--PGNTG--PYGLVG-VPGCSGSKGEQGFP--GLPGTLGYPGI-PGAAGLKGQKGA 158

Query: 1280 QAPRMGLALPGMGGPGPVGTPDIPLGT--APSMPGH-NPMRPPAFLQ-QGMMGPHHRMMS 1335
             A    + L   G PG  G P  P G    P  PG   P  PP F    G MGP      
Sbjct: 159  PAKEEDIELDAKGDPGLPGAPG-PQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPR----- 212

Query: 1336 PAQSTMPGQPTLMSNPAAAVG--MIPGK-DRGPAGLYTHPGPVGS-------PGMMMSMQ 1385
                           P   +G  +I  K +RG  GL   PGP G+       P     ++
Sbjct: 213  --------------GPKGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLK 258

Query: 1386 GMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            G  G +  +  P    P G+  +   G     PG+PG
Sbjct: 259  GEKGDKGAMGEPGPPGPSGLPGE-SYGSEKGAPGDPG 294



 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 83/301 (27%), Positives = 113/301 (37%), Gaps = 45/301 (14%)

Query: 1153 FPHNGPSGGQGSFPGGMGFPG-EGPLGRP--------------SNLPQSSADAALCKPGG 1197
            FP    S GQ  F G  G PG +GP G P              S LP  S    L  PG 
Sbjct: 53   FPGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGFSGSPGL--PGT 110

Query: 1198 PGGPDSFTVLGNSMPSVFTDPDLQEVI-RPGATGIPEFDLSRIIPSEK----PSQTLQYF 1252
            PG    + ++G  +P        Q     PG  G P    +  +  +K      + ++  
Sbjct: 111  PGNTGPYGLVG--VPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKGAPAKEEDIELD 168

Query: 1253 PRGE--VPGRKQPQG-PG-PGFSHMQGMMGEQAPRMGLALPGMGGP----GPVGTPDIPL 1304
             +G+  +PG   PQG PG PGF    G +G   P      PG  GP    G +G   I  
Sbjct: 169  AKGDPGLPGAPGPQGLPGPPGF---PGPVGPPGPPGFFGFPGAMGPRGPKGHMGERVIGH 225

Query: 1305 GTAPSMPG-HNPMRPPAFLQQGMMGPHHRMMSPAQS------TMPGQPTLMSNPAAAVGM 1357
                 + G   P  PP  +   + GP +R     +         PG P     P  + G 
Sbjct: 226  KGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGEKGDKGAMGEPGPPGPSGLPGESYGS 285

Query: 1358 IPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQG 1417
              G   G  GL   PG  G PG   S +G+ G +    +  +   +G   D+G  GF +G
Sbjct: 286  EKGAP-GDPGLQGKPGKDGVPGFPGS-EGVKGNRGFPGLMGEDGIKGQKGDIGPPGF-RG 342

Query: 1418 P 1418
            P
Sbjct: 343  P 343



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 99/398 (24%), Positives = 140/398 (35%), Gaps = 70/398 (17%)

Query: 1047 LPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHG 1106
            LP  +  PG+      P  +GP  +V +P  S            +   P   G    P G
Sbjct: 98   LPGFSGSPGL---PGTPGNTGPYGLVGVPGCS--------GSKGEQGFPGLPGTLGYP-G 145

Query: 1107 VPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFP 1166
            +P   GL           ++  +  +G  G P G P  Q  P    FP  GP G  G  P
Sbjct: 146  IPGAAGLKGQKGAPAK-EEDIELDAKGDPGLP-GAPGPQGLPGPPGFP--GPVGPPGP-P 200

Query: 1167 GGMGFPGE-GPLGRPSNLPQS----SADAALCKPGGPGGPDSFTVLGNSMPSVFTD---- 1217
            G  GFPG  GP G   ++ +       +  +    GP GP    ++  + P   TD    
Sbjct: 201  GFFGFPGAMGPRGPKGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGE 260

Query: 1218 -PDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGM 1276
              D   +  PG  G          PS  P ++  Y      PG    QG  PG   + G 
Sbjct: 261  KGDKGAMGEPGPPG----------PSGLPGES--YGSEKGAPGDPGLQGK-PGKDGVPGF 307

Query: 1277 MGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSP 1336
             G +  +     PG+ G   +      +G            PP F  +G    +      
Sbjct: 308  PGSEGVKGNRGFPGLMGEDGIKGQKGDIG------------PPGF--RGPTEYYDTYQEK 353

Query: 1337 AQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGL-----YTHPGPVGSPGM--MMSMQGMMG 1389
                 PG P     P  A G  P    GP G+      + PG  G+PG   +   +G  G
Sbjct: 354  GDEGTPGPP----GPRGARG--PQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERG 407

Query: 1390 -PQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF 1426
             P ++ M  P     G A   G+ G    PG PG+++F
Sbjct: 408  RPGKDAMGTPGSP--GCAGSPGLPGSPGPPGPPGDIVF 443



 Score = 36.2 bits (82), Expect = 0.23
 Identities = 29/90 (32%), Positives = 39/90 (43%), Gaps = 15/90 (16%)

Query: 1347 LMSNPAAAVGMIPGKDRGPA---------GLYTHPGPVGSPGMM-----MSMQGMMGPQQ 1392
            L + PAA+ G +  KD+G           G    PGP GSPG         + G  GP+ 
Sbjct: 21   LAAAPAASKGCVC-KDKGQCFCDGAKGEKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKG 79

Query: 1393 NIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
               +P     +G+    G+ GFS  PG PG
Sbjct: 80   FPGLPGLTGSKGVRGISGLPGFSGSPGLPG 109



 Score = 35.8 bits (81), Expect = 0.30
 Identities = 64/253 (25%), Positives = 83/253 (32%), Gaps = 49/253 (19%)

Query: 234  LPQQPPAP-ANQDQNSSQNTRLQPT-PPIPAP--APKPAAPPRPLDRES----PGVENKL 285
            L + PP P  N     ++  R  P  P +P    A   A P  P   E     PG+   +
Sbjct: 1174 LLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGAI 1233

Query: 286  IPSV----GSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEP 341
            IP      G P S     P   GP   P +  +       +     PK PP      G P
Sbjct: 1234 IPGQTGNRGPPGSRGS--PGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPP 1291

Query: 342  PTLG-ENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLD---- 396
              LG     GL   + +                 P  + F G +  G + NPG L     
Sbjct: 1292 GRLGAPGTPGLPGPRGD-----------------PGFQGFPGVK--GEKGNPGFLGSIGP 1332

Query: 397  ----GPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVP----- 447
                GP+  P         +  SL   PGP    G P G QG    P  P  + P     
Sbjct: 1333 PGPIGPKGPPGVRGDPGTLKIISLPGSPGPPGTPGEP-GMQGEPGPPGPPGNLGPCGPRG 1391

Query: 448  -PSMNSQSGTIGP 459
             P  + + GT GP
Sbjct: 1392 KPGKDGKPGTPGP 1404



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 1/70 (1%)

Query: 27   MVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLK 86
            ++ PP +  P G P         G +G       P P   K      +A PGP G+ G +
Sbjct: 1129 LLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQ 1188

Query: 87   NGAGN-GAKG 95
               G+ GA G
Sbjct: 1189 GAKGDRGAPG 1198



 Score = 31.2 bits (69), Expect = 7.5
 Identities = 19/70 (27%), Positives = 29/70 (41%), Gaps = 1/70 (1%)

Query: 36  PSGNPQLDSKFSNQGKQGGSASQSQPSPC-DSKSGGHTPKALPGPGGSMGLKNGAGNGAK 94
           P G   L  +  +QG  G   S   P P   +   G+ P+  PG  G+ G+    G   +
Sbjct: 582 PKGELALSGEKGDQGPPGDPGSPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGE 641

Query: 95  GKGKRERSIS 104
              + E S+S
Sbjct: 642 AGPRGELSVS 651


>gi|89142735 alpha 3 type IV collagen isoform 4 precursor [Homo
            sapiens]
          Length = 1494

 Score =  113 bits (283), Expect = 1e-24
 Identities = 249/963 (25%), Positives = 327/963 (33%), Gaps = 250/963 (25%)

Query: 506  GPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGF 565
            G +GV   P PP +  P    +     P   G        P G   HP   G     PG 
Sbjct: 628  GTQGVPGAPGPPGEAGPRGELSVSTPVPGPPG--------PPGPPGHPGPQGP----PGI 675

Query: 566  AGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDG-RNFPPGQGIFSGPGR-GER-FP 622
             G +  +   P +P P   PG+ G+ +P   P  P G + FP  +G    PG+ GE   P
Sbjct: 676  PGSLG-KCGDPGLPGPDGEPGIPGIGFPG--PPGPKGDQGFPGTKGSLGCPGKMGEPGLP 732

Query: 623  NPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPG--NNPIFPRI 680
               GL          E  + +P G    G  P    N     S  H E G    P  P  
Sbjct: 733  GKPGLPGAK-----GEPAVAMPGGPGTPGF-PGERGN-----SGEHGEIGLPGLPGLPGT 781

Query: 681  PVEGPLSPSRGDFPKGIPP--QMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMR 738
            P    L   RGD  +  PP  Q  PGR +E    P G +G   LN   G       Q+ R
Sbjct: 782  PGNEGLDGPRGDPGQPGPPGEQGPPGRCIEG---PRGAQGLPGLNGLKG-------QQGR 831

Query: 739  EAGAGPEEMLKLR-------PG--GSDMLPAQQ-KMVPLPFGEHPQQEYGMGPRPFLPMS 788
                GP+    +        PG  GS  +P  Q +M PL    +P     +GP       
Sbjct: 832  RGKTGPKGDPGIPGLDRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNPGILGP------- 884

Query: 789  QGPGSNS--GLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPL 846
              PG +   G+      IGP           P  P NP +         P QRG      
Sbjct: 885  --PGEDGVIGMMGFPGAIGP-----------PGPPGNPGT---------PGQRG------ 916

Query: 847  DISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIK 906
                      SPGI  +K     Q  +P      G+  +P  PS+++ ++         K
Sbjct: 917  ----------SPGIPGVKG----QRGTPGAKGEQGDKGNPG-PSEISHVIGD-------K 954

Query: 907  SPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVE 966
              P L   A +P    +  +P                PG+      P     P   G++ 
Sbjct: 955  GEPGLKGFAGNPGEKGNRGVPG--------------MPGLKGLKGLPGPAGPPGPRGDLG 1000

Query: 967  SGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYH 1026
            S G P     +P    IPGS                          M    MP S     
Sbjct: 1001 STGNP----GEPGLRGIPGS--------------------------MGNMGMPGS----- 1025

Query: 1027 DAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRIS-GPNPVVPMPTLSPMGMTQP 1085
               K    +      A  P LP ++ + G   +   P  S G  P  P PT  P G+   
Sbjct: 1026 ---KGKRGTLGFPGRAGRPGLPGIHGLQG---DKGEPGYSEGTRPGPPGPTGDP-GLPGD 1078

Query: 1086 LSHSNQMPSPNAVGPNIP--PHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQ---- 1139
            +    +M  P   G   P  P G P  PG          G    P  P G +GF      
Sbjct: 1079 MGKKGEMGQPGPPGHLGPAGPEGAPGSPG--------SPGLPGKPG-PHGDLGFKGIKGL 1129

Query: 1140 -GFPPVQSPPQQVPFPHN-GPSG-----GQGSFPGGMGFPGEGPLGRPSNLPQSSADAAL 1192
             G P ++ PP    FP + GP G     G+   PG  G  GE  L R    P+ +  A  
Sbjct: 1130 LGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQG 1189

Query: 1193 CK-----PGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEK-PS 1246
             K     PG PG P     +G++ P              G TGI  F     +P    P 
Sbjct: 1190 AKGDRGAPGFPGLPGRKGAMGDAGPR-------------GPTGIEGFPGPPGLPGAIIPG 1236

Query: 1247 QTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGT 1306
            QT    P G       P  PGP  SH+ G+ G++          MG PGP G P    GT
Sbjct: 1237 QTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKG--------SMGHPGPKGPP----GT 1284

Query: 1307 APSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPG---QPTLMSNPAAAVGMIPGKDR 1363
            A                 G MGP  R+ +P    +PG    P     P      + G+  
Sbjct: 1285 A-----------------GDMGPPGRLGAPGTPGLPGPRGDPGFQGFPG-----VKGEKG 1322

Query: 1364 GPA--GLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNP 1421
             P   G    PGP+G  G    ++G  G  + I +P    P G   + GM G    PG P
Sbjct: 1323 NPGFLGSIGPPGPIGPKGPP-GVRGDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPPGPP 1381

Query: 1422 GNM 1424
            GN+
Sbjct: 1382 GNL 1384



 Score =  110 bits (276), Expect = 7e-24
 Identities = 251/990 (25%), Positives = 332/990 (33%), Gaps = 199/990 (20%)

Query: 516  PPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGS--QMRLPGFAGMINSE- 572
            P +  +P     PG T P+   + +P     +G    P +PG+     +PG AG+   + 
Sbjct: 99   PGFSGSPGLPGTPGNTGPYGL-VGVPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKG 157

Query: 573  ---MEGPNVPNPASRPGLSGVSWPDDVPKIPD--GRNFPPGQ-GIFSGPGR-GERFPNPQ 625
                E     +    PGL G   P  +P  P   G   PPG  G F  PG  G R P   
Sbjct: 158  APAKEEDIELDAKGDPGLPGAPGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGP--- 214

Query: 626  GLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGP 685
                   +  + E+ +G      ++G+                  P   P    + + GP
Sbjct: 215  -------KGHMGERVIGHKGERGVKGLTG----------------PPGPPGTVIVTLTGP 251

Query: 686  -----LSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNS--------QM 732
                 L   +GD  KG   + GP         PSG+ G+     + GS          Q 
Sbjct: 252  DNRTDLKGEKGD--KGAMGEPGPPG-------PSGLPGE-----SYGSEKGAPGDPGLQG 297

Query: 733  IPQKMREAGAGPEEMLKLRPG-----GSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPM 787
             P K    G    E +K   G     G D +  Q+  +  P    P + Y          
Sbjct: 298  KPGKDGVPGFPGSEGVKGNRGFPGLMGEDGIKGQKGDIGPPGFRGPTEYYDTYQEKGDEG 357

Query: 788  SQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLD 847
            + GP    G R  + P GP           P +P +P S+   L  AP      G K   
Sbjct: 358  TPGPPGPRGARGPQGPSGP-----------PGVPGSPGSSRPGLRGAPGWPGLKGSK--- 403

Query: 848  ISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKS 907
                  +   PG + + +P          GSP G   SP  P    G    P      K 
Sbjct: 404  -----GERGRPGKDAMGTP----------GSP-GCAGSPGLPGS-PGPPGPPGDIVFRKG 446

Query: 908  PPVLGSAAASPVHLKSPSLPAPS-----PGWTSSPKPPLQSP-------------GIPPN 949
            PP        P +L SP +P        PG   +  P +  P             GIP  
Sbjct: 447  PP---GDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGLPGLHGVKGIPGR 503

Query: 950  HKAPLTMASPAMLGNVESGGPP--PPTASQPASVNIPG-SLPSSTPYTMPPEPTLSQNPL 1006
              A     SP   GN    G P  P     P      G +L       +P +P L   P 
Sbjct: 504  QGAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQPEGQVGVPGDPGLRGQPG 563

Query: 1007 SIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPAR-----SPNLPSMNNMPGMGINTQ 1061
               +  +         P     +       D  PP       SP        PG G   +
Sbjct: 564  RKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGSPGPAGPAGPPGYGPQGE 623

Query: 1062 NPRISGPNPVVPMPTLSPMGMTQPLSH-SNQMPSPNAVGPNIPP-HGVPMGPGLMSHNPI 1119
             P + G   V   P   P G   P    S   P P   GP  PP H  P GP  +  +  
Sbjct: 624  -PGLQGTQGVPGAP--GPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGS-- 678

Query: 1120 MGHGSQEPPMVPQGRMGFPQ-GFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLG 1178
            +G         P G  G P  GFP    P     FP  G  G  G  PG MG PG    G
Sbjct: 679  LGKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGFP--GTKGSLGC-PGKMGEPGLP--G 733

Query: 1179 RPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIP------ 1232
            +P  LP +  + A+  PGGPG P      GNS        +  E+  PG  G+P      
Sbjct: 734  KPG-LPGAKGEPAVAMPGGPGTPGFPGERGNS-------GEHGEIGLPGLPGLPGTPGNE 785

Query: 1233 EFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQG-PG-PGFSHMQGMMGEQAPRMGLALPG 1290
              D  R  P +      Q  P   + G +  QG PG  G    QG  G+  P+    +PG
Sbjct: 786  GLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPG 845

Query: 1291 M---GGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTL 1347
            +   G PG  G+P I        PGH          QG MGP        Q   PG P +
Sbjct: 846  LDRSGFPGETGSPGI--------PGH----------QGEMGP------LGQRGYPGNPGI 881

Query: 1348 MSNPA--AAVGMI--PGK--DRGPAGLYTHPGPVGSPGM--------MMSMQGMMGPQQN 1393
            +  P     +GM+  PG     GP G    PG  GSPG+            +G  G + N
Sbjct: 882  LGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGN 941

Query: 1394 IMIPPQMRPRGMAADVGMGGFSQGPGNPGN 1423
                      G   + G+ GF+  PG  GN
Sbjct: 942  PGPSEISHVIGDKGEPGLKGFAGNPGEKGN 971



 Score =  107 bits (267), Expect = 8e-23
 Identities = 309/1274 (24%), Positives = 408/1274 (32%), Gaps = 241/1274 (18%)

Query: 290  GSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLG-ENP 348
            G+PA    +  D  G    P   A  P           P  PP PP   G P  +G   P
Sbjct: 157  GAPAKEEDIELDAKGDPGLPG--APGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGP 214

Query: 349  DG-LSQEQLEHR-ERSLQTLRD--------IQRMLFPDEKEFTGAQSG-----------G 387
             G + +  + H+ ER ++ L          I  +  PD +     + G           G
Sbjct: 215  KGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGEKGDKGAMGEPGPPG 274

Query: 388  PQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVP 447
            P   PG   G +K   G           L   PG     G P G +G +     P  M  
Sbjct: 275  PSGLPGESYGSEKGAPG--------DPGLQGKPGKDGVPGFP-GSEGVKGNRGFPGLMGE 325

Query: 448  PSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGP 507
              +  Q G IGP      T           E+Y+  + K ++        +     Q GP
Sbjct: 326  DGIKGQKGDIGPPGFRGPT-----------EYYDTYQEKGDEGTPGPPGPRGARGPQ-GP 373

Query: 508  RGVVRGPPPPYQMTPSEGWAPGGT----------EPFSDGINMPHSLPPRGMAPHPNMPG 557
             G    P  P    P    APG             P  D +  P S    G A  P +PG
Sbjct: 374  SGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGS---PGCAGSPGLPG 430

Query: 558  S------------------QMRLPGFAGMINSE-MEGPN------------VPNPASRPG 586
            S                     LPG+ G      ++GP             +P P   PG
Sbjct: 431  SPGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPG 490

Query: 587  LSGVSWPDDVPK------IPDGRNFPPGQGIFSGPGRGERFPNPQG---LSEEMFQQQLA 637
            L G+     +P       +      P   G+   PG    FP  QG   L  E  +    
Sbjct: 491  LPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPG----FPGAQGDPGLKGEKGETLQP 546

Query: 638  EKQLGLP--PGM-------AMEGIR--------PSMEMNRMIPGSQRHMEPGNNPIFPRI 680
            E Q+G+P  PG+        ++GI         P  +    + G +    P  +P  P  
Sbjct: 547  EGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGS 606

Query: 681  PVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREA 740
            P  GP  P+    P G  PQ  PG +   G+   G  G        G  S   P      
Sbjct: 607  P--GPAGPAG---PPGYGPQGEPGLQGTQGV--PGAPGPPGEAGPRGELSVSTPVPGPPG 659

Query: 741  GAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNL 800
              GP       P G   +P        P    P  E G+ P    P   GP  + G    
Sbjct: 660  PPGPPG--HPGPQGPPGIPGSLGKCGDPGLPGPDGEPGI-PGIGFPGPPGPKGDQGFPGT 716

Query: 801  REPIG-PDQRTNSRLSHMPPLPLNPSSNPTSLNTAP-----PVQRGLGRKPLDISVAG-- 852
            +  +G P +     L   P LP        ++   P     P +RG   +  +I + G  
Sbjct: 717  KGSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLP 776

Query: 853  SQVHSPGINPLKSPTMHQVQSPMLGS---PSGNLKSPQTPSQLAGMLA-----GPAAAAS 904
                +PG   L  P     Q    G    P   ++ P+    L G+       G      
Sbjct: 777  GLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTG 836

Query: 905  IKSPPVLGSAAAS--PVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPA-- 960
             K  P +     S  P    SP +P            PL   G P N   P  +  P   
Sbjct: 837  PKGDPGIPGLDRSGFPGETGSPGIPGHQ-----GEMGPLGQRGYPGN---PGILGPPGED 888

Query: 961  ----MLGNVESGGPPPP-----TASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMS 1011
                M+G   + GPP P     T  Q  S  IPG            E     NP     S
Sbjct: 889  GVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPGP---S 945

Query: 1012 RMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGP--- 1068
             +S        P     +K  A +  +      P +P +  + G+      P   G    
Sbjct: 946  EISHVIGDKGEP----GLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGPPGPRGDLGS 1001

Query: 1069 --NPVVP----MP-TLSPMGMTQPLSHSNQMPSPNAVG-PNIPP-HGVPMGPGLMSHNPI 1119
              NP  P    +P ++  MGM         +  P   G P +P  HG+    G     P 
Sbjct: 1002 TGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGIHGLQGDKG----EPG 1057

Query: 1120 MGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPG-EGPLG 1178
               G++  P  P G  G P          Q  P  H GP+G +G+ PG  G PG  G  G
Sbjct: 1058 YSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGA-PGSPGSPGLPGKPG 1116

Query: 1179 RPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIP-EFDLS 1237
               +L        L  PG  G P      G+  P        ++ I PG  G   E  L 
Sbjct: 1117 PHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGI-PGPAGEKGETGLL 1175

Query: 1238 RIIPSEKPSQTLQYFPRGEVPGRKQPQG----PG-PGFSHMQGMMGEQAPRMGLALPGMG 1292
            R  P           PRG  PG +  +G    PG PG    +G MG+  PR    + G  
Sbjct: 1176 RAPPG----------PRGN-PGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEGF- 1223

Query: 1293 GPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPA 1352
             PGP G P         +PG          Q G  GP      P     PG P     P 
Sbjct: 1224 -PGPPGLP------GAIIPG----------QTGNRGP------PGSRGSPGAPGPPGPPG 1260

Query: 1353 AAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMG 1412
            + V  I G D+G  G   HPGP G PG      G MGP   +  P      G   D G  
Sbjct: 1261 SHVIGIKG-DKGSMG---HPGPKGPPGTA----GDMGPPGRLGAPGTPGLPGPRGDPGFQ 1312

Query: 1413 GFSQGPGNPGNMMF 1426
            GF    G  GN  F
Sbjct: 1313 GFPGVKGEKGNPGF 1326



 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 192/808 (23%), Positives = 260/808 (32%), Gaps = 162/808 (20%)

Query: 254  LQPTPPIPAPAPKPAAPPRPLDRESPGVENKL-------IP----SVGSPASSTPLPPDG 302
            L  + P+P P   P  P  P  +  PG+   L       +P      G P    P PP  
Sbjct: 648  LSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFPGPPGP 707

Query: 303  TGPNSTPNNRAVTPVSQGSNSSSADPKAPPPP--PVSSGEPPTL---GENPDGLSQEQLE 357
             G    P  +     S G      +P  P  P  P + GEP      G    G   E+  
Sbjct: 708  KGDQGFPGTKG----SLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGN 763

Query: 358  HRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQ--NPGVLDGPQKKPEGP--------IQ 407
              E     L  +  +      E      G P Q   PG    P +  EGP        + 
Sbjct: 764  SGEHGEIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLN 823

Query: 408  AMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTP 467
             +  Q    GK  GP+ D G P       D    P E   P +    G +GP        
Sbjct: 824  GLKGQQGRRGK-TGPKGDPGIP-----GLDRSGFPGETGSPGIPGHQGEMGP-------- 869

Query: 468  EQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM-TPSEGW 526
                   L Q  Y           +     +D ++   G  G +  P PP    TP +  
Sbjct: 870  -------LGQRGYPGNPG------ILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRG 916

Query: 527  APG-----------------------GTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLP 563
            +PG                       G    S  I        +G A +P   G++  +P
Sbjct: 917  SPGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNR-GVP 975

Query: 564  GFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFP--------PG----QGI 611
            G  G+   +     +P PA  PG  G       P  P  R  P        PG    +G 
Sbjct: 976  GMPGLKGLK----GLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGT 1031

Query: 612  FSGPGRGER--FPNPQGLSEEMFQQQLAEKQLGLPPGMAME-GIRPSM----EMNRMIPG 664
               PGR  R   P   GL  +  +   +E     PPG   + G+   M    EM +  PG
Sbjct: 1032 LGFPGRAGRPGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQ--PG 1089

Query: 665  SQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMV-----PSGMKGD 719
               H+ P         P   P SP       G+P + GP  +L F  +     P G++G 
Sbjct: 1090 PPGHLGPAG-------PEGAPGSPG----SPGLPGKPGPHGDLGFKGIKGLLGPPGIRGP 1138

Query: 720  VNLNVNMGSNSQM--IPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEY 777
              L    GS   M     + R+   GP        G + +L A       P  +  + + 
Sbjct: 1139 PGLPGFPGSPGPMGIRGDQGRDGIPGPAG----EKGETGLLRAPPGPRGNPGAQGAKGDR 1194

Query: 778  GMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSS--NPTSLNTAP 835
            G    P LP  +G   ++G      P GP     + +   P  P  P +     + N  P
Sbjct: 1195 GAPGFPGLPGRKGAMGDAG------PRGP-----TGIEGFPGPPGLPGAIIPGQTGNRGP 1243

Query: 836  PVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGS-----PSGNLKSPQTPS 890
            P  RG    P      GS  H  GI   K    H       G+     P G L +P TP 
Sbjct: 1244 PGSRGSPGAPGPPGPPGS--HVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLGAPGTPG 1301

Query: 891  QLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAP-----SPGWTSSPKPPLQSPG 945
                 L GP      +  P +     +P  L S   P P      PG    P   L+   
Sbjct: 1302 -----LPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRGDP-GTLKIIS 1355

Query: 946  IPPNHKAPLTMASPAMLGNVESGGPPPP 973
            +P +   P T   P M G  E G P PP
Sbjct: 1356 LPGSPGPPGTPGEPGMQG--EPGPPGPP 1381



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 239/999 (23%), Positives = 307/999 (30%), Gaps = 209/999 (20%)

Query: 260  IPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPV-- 317
            +P P  + A      D+  PG       S GSP  + P  P G GP   P  +    V  
Sbjct: 579  LPGPKGELALSGEKGDQGPPGDPG----SPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPG 634

Query: 318  ---------SQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRD 368
                      +G  S S     PP PP   G P   G  P G+     +  +  L     
Sbjct: 635  APGPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQG--PPGIPGSLGKCGDPGLPG--- 689

Query: 369  IQRMLFPD-EKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKG--PGPRTD 425
                  PD E    G    GP    G    P  K        M +    GK   PG + +
Sbjct: 690  ------PDGEPGIPGIGFPGPPGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGE 743

Query: 426  --VGAPFGP-----QGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHM-----TPEQIAWL 473
              V  P GP      G R       E+  P +    GT G + LD        P      
Sbjct: 744  PAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQ 803

Query: 474  KLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEP 533
                   E  R  Q    +     Q     + GP+G    P       P E  +PG   P
Sbjct: 804  GPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGSPG--IP 861

Query: 534  FSDGINMPHSLPPRGMAPHPNMPG--------SQMRLPGFAGMINSEMEGPNVPNPASRP 585
               G      + P G   +P  PG          + + GF G I     GP  P P   P
Sbjct: 862  GHQG-----EMGPLGQRGYPGNPGILGPPGEDGVIGMMGFPGAI-----GP--PGPPGNP 909

Query: 586  GLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPP 645
            G  G      +P +   R  P  +G     G     P P  +S  +  +          P
Sbjct: 910  GTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGN----PGPSEISHVIGDKG--------EP 957

Query: 646  GMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGR 705
            G+      P  + NR +PG      PG   +                  KG+P   G   
Sbjct: 958  GLKGFAGNPGEKGNRGVPGM-----PGLKGL------------------KGLPGPAG--- 991

Query: 706  ELEFGMVPSGMKGDVNLNVNMGS-NSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKM 764
                   P G +GD+    N G    + IP  M   G    +  +    G+   P +   
Sbjct: 992  -------PPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKR----GTLGFPGRAGR 1040

Query: 765  VPLP-----FGEHPQQEYGMGPRPFLPMSQG----PGSNSGLRNLREPIGPDQRTNSRLS 815
              LP      G+  +  Y  G RP  P   G    PG       + +P GP         
Sbjct: 1041 PGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQP-GPPGHLG---- 1095

Query: 816  HMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPM 875
                 P  P   P S     P   GL  KP      G +    GI  L  P       P 
Sbjct: 1096 -----PAGPEGAPGS-----PGSPGLPGKPGPHGDLGFK----GIKGLLGP-------PG 1134

Query: 876  LGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTS 935
            +  P G    P +P  +   + G      I  P   G    + + L++P  P  +PG   
Sbjct: 1135 IRGPPGLPGFPGSPGPMG--IRGDQGRDGIPGP--AGEKGETGL-LRAPPGPRGNPG-AQ 1188

Query: 936  SPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQ--PASVNIPGS-LPSSTP 992
              K    +PG P           P   G +   GP  PT  +  P    +PG+ +P  T 
Sbjct: 1189 GAKGDRGAPGFP---------GLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGAIIPGQTG 1239

Query: 993  YTMPPEPTLSQNPLSIMMSRMSKFAM-PSSTPLYH-DAIKTVASSDDDSPPARSPNLPSM 1050
               PP             SR S  A  P   P  H   IK    S     P   P     
Sbjct: 1240 NRGPPG------------SRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGD 1287

Query: 1051 NNMPGMGINTQNPRISGP-NPVVPMPTLSP--------MGMTQPLSHSNQMPSPNAVGPN 1101
               PG        R+  P  P +P P   P         G          +  P  +GP 
Sbjct: 1288 MGPPG--------RLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPK 1339

Query: 1102 IPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGG 1161
             PP GV   PG +    I   GS  PP  P G  G  QG P    PP  +     GP G 
Sbjct: 1340 GPP-GVRGDPGTL--KIISLPGSPGPPGTP-GEPGM-QGEPGPPGPPGNL-----GPCGP 1389

Query: 1162 QGSFPGGMGFPG-EGPLGRPSNLPQSSADAALCKPGGPG 1199
            +G  PG  G PG  GP G   N             G PG
Sbjct: 1390 RGK-PGKDGKPGTPGPAGEKGNKGSKGEPGPAGSDGLPG 1427



 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 80/277 (28%), Positives = 103/277 (37%), Gaps = 46/277 (16%)

Query: 1161 GQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLG-NSMPSVFTDPD 1219
            G+  FPG  G PG+     P  LP          PG PG   S  V G + +P     P 
Sbjct: 49   GEKGFPGPPGSPGQKGFTGPEGLPGPQGPKGF--PGLPGLTGSKGVRGISGLPGFSGSPG 106

Query: 1220 LQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGE 1279
            L     PG TG   + L   +P    S+  Q FP   +PG     G  PG + ++G  G 
Sbjct: 107  LPGT--PGNTG--PYGLVG-VPGCSGSKGEQGFP--GLPGTLGYPGI-PGAAGLKGQKGA 158

Query: 1280 QAPRMGLALPGMGGPGPVGTPDIPLGT--APSMPGH-NPMRPPAFLQ-QGMMGPHHRMMS 1335
             A    + L   G PG  G P  P G    P  PG   P  PP F    G MGP      
Sbjct: 159  PAKEEDIELDAKGDPGLPGAPG-PQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPR----- 212

Query: 1336 PAQSTMPGQPTLMSNPAAAVG--MIPGK-DRGPAGLYTHPGPVGS-------PGMMMSMQ 1385
                           P   +G  +I  K +RG  GL   PGP G+       P     ++
Sbjct: 213  --------------GPKGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLK 258

Query: 1386 GMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            G  G +  +  P    P G+  +   G     PG+PG
Sbjct: 259  GEKGDKGAMGEPGPPGPSGLPGE-SYGSEKGAPGDPG 294



 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 83/301 (27%), Positives = 113/301 (37%), Gaps = 45/301 (14%)

Query: 1153 FPHNGPSGGQGSFPGGMGFPG-EGPLGRP--------------SNLPQSSADAALCKPGG 1197
            FP    S GQ  F G  G PG +GP G P              S LP  S    L  PG 
Sbjct: 53   FPGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGFSGSPGL--PGT 110

Query: 1198 PGGPDSFTVLGNSMPSVFTDPDLQEVI-RPGATGIPEFDLSRIIPSEK----PSQTLQYF 1252
            PG    + ++G  +P        Q     PG  G P    +  +  +K      + ++  
Sbjct: 111  PGNTGPYGLVG--VPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKGAPAKEEDIELD 168

Query: 1253 PRGE--VPGRKQPQG-PG-PGFSHMQGMMGEQAPRMGLALPGMGGP----GPVGTPDIPL 1304
             +G+  +PG   PQG PG PGF    G +G   P      PG  GP    G +G   I  
Sbjct: 169  AKGDPGLPGAPGPQGLPGPPGF---PGPVGPPGPPGFFGFPGAMGPRGPKGHMGERVIGH 225

Query: 1305 GTAPSMPG-HNPMRPPAFLQQGMMGPHHRMMSPAQS------TMPGQPTLMSNPAAAVGM 1357
                 + G   P  PP  +   + GP +R     +         PG P     P  + G 
Sbjct: 226  KGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGEKGDKGAMGEPGPPGPSGLPGESYGS 285

Query: 1358 IPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQG 1417
              G   G  GL   PG  G PG   S +G+ G +    +  +   +G   D+G  GF +G
Sbjct: 286  EKGAP-GDPGLQGKPGKDGVPGFPGS-EGVKGNRGFPGLMGEDGIKGQKGDIGPPGF-RG 342

Query: 1418 P 1418
            P
Sbjct: 343  P 343



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 99/398 (24%), Positives = 140/398 (35%), Gaps = 70/398 (17%)

Query: 1047 LPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHG 1106
            LP  +  PG+      P  +GP  +V +P  S            +   P   G    P G
Sbjct: 98   LPGFSGSPGL---PGTPGNTGPYGLVGVPGCS--------GSKGEQGFPGLPGTLGYP-G 145

Query: 1107 VPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFP 1166
            +P   GL           ++  +  +G  G P G P  Q  P    FP  GP G  G  P
Sbjct: 146  IPGAAGLKGQKGAPAK-EEDIELDAKGDPGLP-GAPGPQGLPGPPGFP--GPVGPPGP-P 200

Query: 1167 GGMGFPGE-GPLGRPSNLPQS----SADAALCKPGGPGGPDSFTVLGNSMPSVFTD---- 1217
            G  GFPG  GP G   ++ +       +  +    GP GP    ++  + P   TD    
Sbjct: 201  GFFGFPGAMGPRGPKGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGE 260

Query: 1218 -PDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGM 1276
              D   +  PG  G          PS  P ++  Y      PG    QG  PG   + G 
Sbjct: 261  KGDKGAMGEPGPPG----------PSGLPGES--YGSEKGAPGDPGLQGK-PGKDGVPGF 307

Query: 1277 MGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSP 1336
             G +  +     PG+ G   +      +G            PP F  +G    +      
Sbjct: 308  PGSEGVKGNRGFPGLMGEDGIKGQKGDIG------------PPGF--RGPTEYYDTYQEK 353

Query: 1337 AQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGL-----YTHPGPVGSPGM--MMSMQGMMG 1389
                 PG P     P  A G  P    GP G+      + PG  G+PG   +   +G  G
Sbjct: 354  GDEGTPGPP----GPRGARG--PQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERG 407

Query: 1390 -PQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF 1426
             P ++ M  P     G A   G+ G    PG PG+++F
Sbjct: 408  RPGKDAMGTPGSP--GCAGSPGLPGSPGPPGPPGDIVF 443



 Score = 36.2 bits (82), Expect = 0.23
 Identities = 29/90 (32%), Positives = 39/90 (43%), Gaps = 15/90 (16%)

Query: 1347 LMSNPAAAVGMIPGKDRGPA---------GLYTHPGPVGSPGMM-----MSMQGMMGPQQ 1392
            L + PAA+ G +  KD+G           G    PGP GSPG         + G  GP+ 
Sbjct: 21   LAAAPAASKGCVC-KDKGQCFCDGAKGEKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKG 79

Query: 1393 NIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
               +P     +G+    G+ GFS  PG PG
Sbjct: 80   FPGLPGLTGSKGVRGISGLPGFSGSPGLPG 109



 Score = 35.8 bits (81), Expect = 0.30
 Identities = 64/253 (25%), Positives = 83/253 (32%), Gaps = 49/253 (19%)

Query: 234  LPQQPPAP-ANQDQNSSQNTRLQPT-PPIPAP--APKPAAPPRPLDRES----PGVENKL 285
            L + PP P  N     ++  R  P  P +P    A   A P  P   E     PG+   +
Sbjct: 1174 LLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGAI 1233

Query: 286  IPSV----GSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEP 341
            IP      G P S     P   GP   P +  +       +     PK PP      G P
Sbjct: 1234 IPGQTGNRGPPGSRGS--PGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPP 1291

Query: 342  PTLG-ENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLD---- 396
              LG     GL   + +                 P  + F G +  G + NPG L     
Sbjct: 1292 GRLGAPGTPGLPGPRGD-----------------PGFQGFPGVK--GEKGNPGFLGSIGP 1332

Query: 397  ----GPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVP----- 447
                GP+  P         +  SL   PGP    G P G QG    P  P  + P     
Sbjct: 1333 PGPIGPKGPPGVRGDPGTLKIISLPGSPGPPGTPGEP-GMQGEPGPPGPPGNLGPCGPRG 1391

Query: 448  -PSMNSQSGTIGP 459
             P  + + GT GP
Sbjct: 1392 KPGKDGKPGTPGP 1404



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 1/70 (1%)

Query: 27   MVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLK 86
            ++ PP +  P G P         G +G       P P   K      +A PGP G+ G +
Sbjct: 1129 LLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQ 1188

Query: 87   NGAGN-GAKG 95
               G+ GA G
Sbjct: 1189 GAKGDRGAPG 1198



 Score = 31.2 bits (69), Expect = 7.5
 Identities = 19/70 (27%), Positives = 29/70 (41%), Gaps = 1/70 (1%)

Query: 36  PSGNPQLDSKFSNQGKQGGSASQSQPSPC-DSKSGGHTPKALPGPGGSMGLKNGAGNGAK 94
           P G   L  +  +QG  G   S   P P   +   G+ P+  PG  G+ G+    G   +
Sbjct: 582 PKGELALSGEKGDQGPPGDPGSPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGE 641

Query: 95  GKGKRERSIS 104
              + E S+S
Sbjct: 642 AGPRGELSVS 651


>gi|89142733 alpha 3 type IV collagen isoform 2 precursor [Homo
            sapiens]
          Length = 1637

 Score =  113 bits (283), Expect = 1e-24
 Identities = 249/963 (25%), Positives = 327/963 (33%), Gaps = 250/963 (25%)

Query: 506  GPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGF 565
            G +GV   P PP +  P    +     P   G        P G   HP   G     PG 
Sbjct: 628  GTQGVPGAPGPPGEAGPRGELSVSTPVPGPPG--------PPGPPGHPGPQGP----PGI 675

Query: 566  AGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDG-RNFPPGQGIFSGPGR-GER-FP 622
             G +  +   P +P P   PG+ G+ +P   P  P G + FP  +G    PG+ GE   P
Sbjct: 676  PGSLG-KCGDPGLPGPDGEPGIPGIGFPG--PPGPKGDQGFPGTKGSLGCPGKMGEPGLP 732

Query: 623  NPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPG--NNPIFPRI 680
               GL          E  + +P G    G  P    N     S  H E G    P  P  
Sbjct: 733  GKPGLPGAK-----GEPAVAMPGGPGTPGF-PGERGN-----SGEHGEIGLPGLPGLPGT 781

Query: 681  PVEGPLSPSRGDFPKGIPP--QMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMR 738
            P    L   RGD  +  PP  Q  PGR +E    P G +G   LN   G       Q+ R
Sbjct: 782  PGNEGLDGPRGDPGQPGPPGEQGPPGRCIEG---PRGAQGLPGLNGLKG-------QQGR 831

Query: 739  EAGAGPEEMLKLR-------PG--GSDMLPAQQ-KMVPLPFGEHPQQEYGMGPRPFLPMS 788
                GP+    +        PG  GS  +P  Q +M PL    +P     +GP       
Sbjct: 832  RGKTGPKGDPGIPGLDRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNPGILGP------- 884

Query: 789  QGPGSNS--GLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPL 846
              PG +   G+      IGP           P  P NP +         P QRG      
Sbjct: 885  --PGEDGVIGMMGFPGAIGP-----------PGPPGNPGT---------PGQRG------ 916

Query: 847  DISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIK 906
                      SPGI  +K     Q  +P      G+  +P  PS+++ ++         K
Sbjct: 917  ----------SPGIPGVKG----QRGTPGAKGEQGDKGNPG-PSEISHVIGD-------K 954

Query: 907  SPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVE 966
              P L   A +P    +  +P                PG+      P     P   G++ 
Sbjct: 955  GEPGLKGFAGNPGEKGNRGVPG--------------MPGLKGLKGLPGPAGPPGPRGDLG 1000

Query: 967  SGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYH 1026
            S G P     +P    IPGS                          M    MP S     
Sbjct: 1001 STGNP----GEPGLRGIPGS--------------------------MGNMGMPGS----- 1025

Query: 1027 DAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRIS-GPNPVVPMPTLSPMGMTQP 1085
               K    +      A  P LP ++ + G   +   P  S G  P  P PT  P G+   
Sbjct: 1026 ---KGKRGTLGFPGRAGRPGLPGIHGLQG---DKGEPGYSEGTRPGPPGPTGDP-GLPGD 1078

Query: 1086 LSHSNQMPSPNAVGPNIP--PHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQ---- 1139
            +    +M  P   G   P  P G P  PG          G    P  P G +GF      
Sbjct: 1079 MGKKGEMGQPGPPGHLGPAGPEGAPGSPG--------SPGLPGKPG-PHGDLGFKGIKGL 1129

Query: 1140 -GFPPVQSPPQQVPFPHN-GPSG-----GQGSFPGGMGFPGEGPLGRPSNLPQSSADAAL 1192
             G P ++ PP    FP + GP G     G+   PG  G  GE  L R    P+ +  A  
Sbjct: 1130 LGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQG 1189

Query: 1193 CK-----PGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEK-PS 1246
             K     PG PG P     +G++ P              G TGI  F     +P    P 
Sbjct: 1190 AKGDRGAPGFPGLPGRKGAMGDAGPR-------------GPTGIEGFPGPPGLPGAIIPG 1236

Query: 1247 QTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGT 1306
            QT    P G       P  PGP  SH+ G+ G++          MG PGP G P    GT
Sbjct: 1237 QTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKG--------SMGHPGPKGPP----GT 1284

Query: 1307 APSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPG---QPTLMSNPAAAVGMIPGKDR 1363
            A                 G MGP  R+ +P    +PG    P     P      + G+  
Sbjct: 1285 A-----------------GDMGPPGRLGAPGTPGLPGPRGDPGFQGFPG-----VKGEKG 1322

Query: 1364 GPA--GLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNP 1421
             P   G    PGP+G  G    ++G  G  + I +P    P G   + GM G    PG P
Sbjct: 1323 NPGFLGSIGPPGPIGPKGPP-GVRGDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPPGPP 1381

Query: 1422 GNM 1424
            GN+
Sbjct: 1382 GNL 1384



 Score =  110 bits (276), Expect = 7e-24
 Identities = 251/990 (25%), Positives = 332/990 (33%), Gaps = 199/990 (20%)

Query: 516  PPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGS--QMRLPGFAGMINSE- 572
            P +  +P     PG T P+   + +P     +G    P +PG+     +PG AG+   + 
Sbjct: 99   PGFSGSPGLPGTPGNTGPYGL-VGVPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKG 157

Query: 573  ---MEGPNVPNPASRPGLSGVSWPDDVPKIPD--GRNFPPGQ-GIFSGPGR-GERFPNPQ 625
                E     +    PGL G   P  +P  P   G   PPG  G F  PG  G R P   
Sbjct: 158  APAKEEDIELDAKGDPGLPGAPGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGP--- 214

Query: 626  GLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGP 685
                   +  + E+ +G      ++G+                  P   P    + + GP
Sbjct: 215  -------KGHMGERVIGHKGERGVKGLTG----------------PPGPPGTVIVTLTGP 251

Query: 686  -----LSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNS--------QM 732
                 L   +GD  KG   + GP         PSG+ G+     + GS          Q 
Sbjct: 252  DNRTDLKGEKGD--KGAMGEPGPPG-------PSGLPGE-----SYGSEKGAPGDPGLQG 297

Query: 733  IPQKMREAGAGPEEMLKLRPG-----GSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPM 787
             P K    G    E +K   G     G D +  Q+  +  P    P + Y          
Sbjct: 298  KPGKDGVPGFPGSEGVKGNRGFPGLMGEDGIKGQKGDIGPPGFRGPTEYYDTYQEKGDEG 357

Query: 788  SQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLD 847
            + GP    G R  + P GP           P +P +P S+   L  AP      G K   
Sbjct: 358  TPGPPGPRGARGPQGPSGP-----------PGVPGSPGSSRPGLRGAPGWPGLKGSK--- 403

Query: 848  ISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKS 907
                  +   PG + + +P          GSP G   SP  P    G    P      K 
Sbjct: 404  -----GERGRPGKDAMGTP----------GSP-GCAGSPGLPGS-PGPPGPPGDIVFRKG 446

Query: 908  PPVLGSAAASPVHLKSPSLPAPS-----PGWTSSPKPPLQSP-------------GIPPN 949
            PP        P +L SP +P        PG   +  P +  P             GIP  
Sbjct: 447  PP---GDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGLPGLHGVKGIPGR 503

Query: 950  HKAPLTMASPAMLGNVESGGPP--PPTASQPASVNIPG-SLPSSTPYTMPPEPTLSQNPL 1006
              A     SP   GN    G P  P     P      G +L       +P +P L   P 
Sbjct: 504  QGAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQPEGQVGVPGDPGLRGQPG 563

Query: 1007 SIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPAR-----SPNLPSMNNMPGMGINTQ 1061
               +  +         P     +       D  PP       SP        PG G   +
Sbjct: 564  RKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGSPGPAGPAGPPGYGPQGE 623

Query: 1062 NPRISGPNPVVPMPTLSPMGMTQPLSH-SNQMPSPNAVGPNIPP-HGVPMGPGLMSHNPI 1119
             P + G   V   P   P G   P    S   P P   GP  PP H  P GP  +  +  
Sbjct: 624  -PGLQGTQGVPGAP--GPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGS-- 678

Query: 1120 MGHGSQEPPMVPQGRMGFPQ-GFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLG 1178
            +G         P G  G P  GFP    P     FP  G  G  G  PG MG PG    G
Sbjct: 679  LGKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGFP--GTKGSLGC-PGKMGEPGLP--G 733

Query: 1179 RPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIP------ 1232
            +P  LP +  + A+  PGGPG P      GNS        +  E+  PG  G+P      
Sbjct: 734  KPG-LPGAKGEPAVAMPGGPGTPGFPGERGNS-------GEHGEIGLPGLPGLPGTPGNE 785

Query: 1233 EFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQG-PG-PGFSHMQGMMGEQAPRMGLALPG 1290
              D  R  P +      Q  P   + G +  QG PG  G    QG  G+  P+    +PG
Sbjct: 786  GLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPG 845

Query: 1291 M---GGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTL 1347
            +   G PG  G+P I        PGH          QG MGP        Q   PG P +
Sbjct: 846  LDRSGFPGETGSPGI--------PGH----------QGEMGP------LGQRGYPGNPGI 881

Query: 1348 MSNPA--AAVGMI--PGK--DRGPAGLYTHPGPVGSPGM--------MMSMQGMMGPQQN 1393
            +  P     +GM+  PG     GP G    PG  GSPG+            +G  G + N
Sbjct: 882  LGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGN 941

Query: 1394 IMIPPQMRPRGMAADVGMGGFSQGPGNPGN 1423
                      G   + G+ GF+  PG  GN
Sbjct: 942  PGPSEISHVIGDKGEPGLKGFAGNPGEKGN 971



 Score =  107 bits (267), Expect = 8e-23
 Identities = 309/1274 (24%), Positives = 408/1274 (32%), Gaps = 241/1274 (18%)

Query: 290  GSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLG-ENP 348
            G+PA    +  D  G    P   A  P           P  PP PP   G P  +G   P
Sbjct: 157  GAPAKEEDIELDAKGDPGLPG--APGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGP 214

Query: 349  DG-LSQEQLEHR-ERSLQTLRD--------IQRMLFPDEKEFTGAQSG-----------G 387
             G + +  + H+ ER ++ L          I  +  PD +     + G           G
Sbjct: 215  KGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGEKGDKGAMGEPGPPG 274

Query: 388  PQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVP 447
            P   PG   G +K   G           L   PG     G P G +G +     P  M  
Sbjct: 275  PSGLPGESYGSEKGAPG--------DPGLQGKPGKDGVPGFP-GSEGVKGNRGFPGLMGE 325

Query: 448  PSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGP 507
              +  Q G IGP      T           E+Y+  + K ++        +     Q GP
Sbjct: 326  DGIKGQKGDIGPPGFRGPT-----------EYYDTYQEKGDEGTPGPPGPRGARGPQ-GP 373

Query: 508  RGVVRGPPPPYQMTPSEGWAPGGT----------EPFSDGINMPHSLPPRGMAPHPNMPG 557
             G    P  P    P    APG             P  D +  P S    G A  P +PG
Sbjct: 374  SGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGS---PGCAGSPGLPG 430

Query: 558  S------------------QMRLPGFAGMINSE-MEGPN------------VPNPASRPG 586
            S                     LPG+ G      ++GP             +P P   PG
Sbjct: 431  SPGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPG 490

Query: 587  LSGVSWPDDVPK------IPDGRNFPPGQGIFSGPGRGERFPNPQG---LSEEMFQQQLA 637
            L G+     +P       +      P   G+   PG    FP  QG   L  E  +    
Sbjct: 491  LPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPG----FPGAQGDPGLKGEKGETLQP 546

Query: 638  EKQLGLP--PGM-------AMEGIR--------PSMEMNRMIPGSQRHMEPGNNPIFPRI 680
            E Q+G+P  PG+        ++GI         P  +    + G +    P  +P  P  
Sbjct: 547  EGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGS 606

Query: 681  PVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREA 740
            P  GP  P+    P G  PQ  PG +   G+   G  G        G  S   P      
Sbjct: 607  P--GPAGPAG---PPGYGPQGEPGLQGTQGV--PGAPGPPGEAGPRGELSVSTPVPGPPG 659

Query: 741  GAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNL 800
              GP       P G   +P        P    P  E G+ P    P   GP  + G    
Sbjct: 660  PPGPPG--HPGPQGPPGIPGSLGKCGDPGLPGPDGEPGI-PGIGFPGPPGPKGDQGFPGT 716

Query: 801  REPIG-PDQRTNSRLSHMPPLPLNPSSNPTSLNTAP-----PVQRGLGRKPLDISVAG-- 852
            +  +G P +     L   P LP        ++   P     P +RG   +  +I + G  
Sbjct: 717  KGSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLP 776

Query: 853  SQVHSPGINPLKSPTMHQVQSPMLGS---PSGNLKSPQTPSQLAGMLA-----GPAAAAS 904
                +PG   L  P     Q    G    P   ++ P+    L G+       G      
Sbjct: 777  GLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTG 836

Query: 905  IKSPPVLGSAAAS--PVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPA-- 960
             K  P +     S  P    SP +P            PL   G P N   P  +  P   
Sbjct: 837  PKGDPGIPGLDRSGFPGETGSPGIPGHQ-----GEMGPLGQRGYPGN---PGILGPPGED 888

Query: 961  ----MLGNVESGGPPPP-----TASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMS 1011
                M+G   + GPP P     T  Q  S  IPG            E     NP     S
Sbjct: 889  GVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPGP---S 945

Query: 1012 RMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGP--- 1068
             +S        P     +K  A +  +      P +P +  + G+      P   G    
Sbjct: 946  EISHVIGDKGEP----GLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGPPGPRGDLGS 1001

Query: 1069 --NPVVP----MP-TLSPMGMTQPLSHSNQMPSPNAVG-PNIPP-HGVPMGPGLMSHNPI 1119
              NP  P    +P ++  MGM         +  P   G P +P  HG+    G     P 
Sbjct: 1002 TGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGIHGLQGDKG----EPG 1057

Query: 1120 MGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPG-EGPLG 1178
               G++  P  P G  G P          Q  P  H GP+G +G+ PG  G PG  G  G
Sbjct: 1058 YSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGA-PGSPGSPGLPGKPG 1116

Query: 1179 RPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIP-EFDLS 1237
               +L        L  PG  G P      G+  P        ++ I PG  G   E  L 
Sbjct: 1117 PHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGI-PGPAGEKGETGLL 1175

Query: 1238 RIIPSEKPSQTLQYFPRGEVPGRKQPQG----PG-PGFSHMQGMMGEQAPRMGLALPGMG 1292
            R  P           PRG  PG +  +G    PG PG    +G MG+  PR    + G  
Sbjct: 1176 RAPPG----------PRGN-PGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEGF- 1223

Query: 1293 GPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPA 1352
             PGP G P         +PG          Q G  GP      P     PG P     P 
Sbjct: 1224 -PGPPGLP------GAIIPG----------QTGNRGP------PGSRGSPGAPGPPGPPG 1260

Query: 1353 AAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMG 1412
            + V  I G D+G  G   HPGP G PG      G MGP   +  P      G   D G  
Sbjct: 1261 SHVIGIKG-DKGSMG---HPGPKGPPGTA----GDMGPPGRLGAPGTPGLPGPRGDPGFQ 1312

Query: 1413 GFSQGPGNPGNMMF 1426
            GF    G  GN  F
Sbjct: 1313 GFPGVKGEKGNPGF 1326



 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 192/808 (23%), Positives = 260/808 (32%), Gaps = 162/808 (20%)

Query: 254  LQPTPPIPAPAPKPAAPPRPLDRESPGVENKL-------IP----SVGSPASSTPLPPDG 302
            L  + P+P P   P  P  P  +  PG+   L       +P      G P    P PP  
Sbjct: 648  LSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFPGPPGP 707

Query: 303  TGPNSTPNNRAVTPVSQGSNSSSADPKAPPPP--PVSSGEPPTL---GENPDGLSQEQLE 357
             G    P  +     S G      +P  P  P  P + GEP      G    G   E+  
Sbjct: 708  KGDQGFPGTKG----SLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGN 763

Query: 358  HRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQ--NPGVLDGPQKKPEGP--------IQ 407
              E     L  +  +      E      G P Q   PG    P +  EGP        + 
Sbjct: 764  SGEHGEIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLN 823

Query: 408  AMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTP 467
             +  Q    GK  GP+ D G P       D    P E   P +    G +GP        
Sbjct: 824  GLKGQQGRRGK-TGPKGDPGIP-----GLDRSGFPGETGSPGIPGHQGEMGP-------- 869

Query: 468  EQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM-TPSEGW 526
                   L Q  Y           +     +D ++   G  G +  P PP    TP +  
Sbjct: 870  -------LGQRGYPGNPG------ILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRG 916

Query: 527  APG-----------------------GTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLP 563
            +PG                       G    S  I        +G A +P   G++  +P
Sbjct: 917  SPGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNR-GVP 975

Query: 564  GFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFP--------PG----QGI 611
            G  G+   +     +P PA  PG  G       P  P  R  P        PG    +G 
Sbjct: 976  GMPGLKGLK----GLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGT 1031

Query: 612  FSGPGRGER--FPNPQGLSEEMFQQQLAEKQLGLPPGMAME-GIRPSM----EMNRMIPG 664
               PGR  R   P   GL  +  +   +E     PPG   + G+   M    EM +  PG
Sbjct: 1032 LGFPGRAGRPGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQ--PG 1089

Query: 665  SQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMV-----PSGMKGD 719
               H+ P         P   P SP       G+P + GP  +L F  +     P G++G 
Sbjct: 1090 PPGHLGPAG-------PEGAPGSPG----SPGLPGKPGPHGDLGFKGIKGLLGPPGIRGP 1138

Query: 720  VNLNVNMGSNSQM--IPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEY 777
              L    GS   M     + R+   GP        G + +L A       P  +  + + 
Sbjct: 1139 PGLPGFPGSPGPMGIRGDQGRDGIPGPAG----EKGETGLLRAPPGPRGNPGAQGAKGDR 1194

Query: 778  GMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSS--NPTSLNTAP 835
            G    P LP  +G   ++G      P GP     + +   P  P  P +     + N  P
Sbjct: 1195 GAPGFPGLPGRKGAMGDAG------PRGP-----TGIEGFPGPPGLPGAIIPGQTGNRGP 1243

Query: 836  PVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGS-----PSGNLKSPQTPS 890
            P  RG    P      GS  H  GI   K    H       G+     P G L +P TP 
Sbjct: 1244 PGSRGSPGAPGPPGPPGS--HVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLGAPGTPG 1301

Query: 891  QLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAP-----SPGWTSSPKPPLQSPG 945
                 L GP      +  P +     +P  L S   P P      PG    P   L+   
Sbjct: 1302 -----LPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRGDP-GTLKIIS 1355

Query: 946  IPPNHKAPLTMASPAMLGNVESGGPPPP 973
            +P +   P T   P M G  E G P PP
Sbjct: 1356 LPGSPGPPGTPGEPGMQG--EPGPPGPP 1381



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 239/999 (23%), Positives = 307/999 (30%), Gaps = 209/999 (20%)

Query: 260  IPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPV-- 317
            +P P  + A      D+  PG       S GSP  + P  P G GP   P  +    V  
Sbjct: 579  LPGPKGELALSGEKGDQGPPGDPG----SPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPG 634

Query: 318  ---------SQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRD 368
                      +G  S S     PP PP   G P   G  P G+     +  +  L     
Sbjct: 635  APGPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQG--PPGIPGSLGKCGDPGLPG--- 689

Query: 369  IQRMLFPD-EKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKG--PGPRTD 425
                  PD E    G    GP    G    P  K        M +    GK   PG + +
Sbjct: 690  ------PDGEPGIPGIGFPGPPGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGE 743

Query: 426  --VGAPFGP-----QGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHM-----TPEQIAWL 473
              V  P GP      G R       E+  P +    GT G + LD        P      
Sbjct: 744  PAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQ 803

Query: 474  KLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEP 533
                   E  R  Q    +     Q     + GP+G    P       P E  +PG   P
Sbjct: 804  GPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGSPG--IP 861

Query: 534  FSDGINMPHSLPPRGMAPHPNMPG--------SQMRLPGFAGMINSEMEGPNVPNPASRP 585
               G      + P G   +P  PG          + + GF G I     GP  P P   P
Sbjct: 862  GHQG-----EMGPLGQRGYPGNPGILGPPGEDGVIGMMGFPGAI-----GP--PGPPGNP 909

Query: 586  GLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPP 645
            G  G      +P +   R  P  +G     G     P P  +S  +  +          P
Sbjct: 910  GTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGN----PGPSEISHVIGDKG--------EP 957

Query: 646  GMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGR 705
            G+      P  + NR +PG      PG   +                  KG+P   G   
Sbjct: 958  GLKGFAGNPGEKGNRGVPGM-----PGLKGL------------------KGLPGPAG--- 991

Query: 706  ELEFGMVPSGMKGDVNLNVNMGS-NSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKM 764
                   P G +GD+    N G    + IP  M   G    +  +    G+   P +   
Sbjct: 992  -------PPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKR----GTLGFPGRAGR 1040

Query: 765  VPLP-----FGEHPQQEYGMGPRPFLPMSQG----PGSNSGLRNLREPIGPDQRTNSRLS 815
              LP      G+  +  Y  G RP  P   G    PG       + +P GP         
Sbjct: 1041 PGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQP-GPPGHLG---- 1095

Query: 816  HMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPM 875
                 P  P   P S     P   GL  KP      G +    GI  L  P       P 
Sbjct: 1096 -----PAGPEGAPGS-----PGSPGLPGKPGPHGDLGFK----GIKGLLGP-------PG 1134

Query: 876  LGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTS 935
            +  P G    P +P  +   + G      I  P   G    + + L++P  P  +PG   
Sbjct: 1135 IRGPPGLPGFPGSPGPMG--IRGDQGRDGIPGP--AGEKGETGL-LRAPPGPRGNPG-AQ 1188

Query: 936  SPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQ--PASVNIPGS-LPSSTP 992
              K    +PG P           P   G +   GP  PT  +  P    +PG+ +P  T 
Sbjct: 1189 GAKGDRGAPGFP---------GLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGAIIPGQTG 1239

Query: 993  YTMPPEPTLSQNPLSIMMSRMSKFAM-PSSTPLYH-DAIKTVASSDDDSPPARSPNLPSM 1050
               PP             SR S  A  P   P  H   IK    S     P   P     
Sbjct: 1240 NRGPPG------------SRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGD 1287

Query: 1051 NNMPGMGINTQNPRISGP-NPVVPMPTLSP--------MGMTQPLSHSNQMPSPNAVGPN 1101
               PG        R+  P  P +P P   P         G          +  P  +GP 
Sbjct: 1288 MGPPG--------RLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPK 1339

Query: 1102 IPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGG 1161
             PP GV   PG +    I   GS  PP  P G  G  QG P    PP  +     GP G 
Sbjct: 1340 GPP-GVRGDPGTL--KIISLPGSPGPPGTP-GEPGM-QGEPGPPGPPGNL-----GPCGP 1389

Query: 1162 QGSFPGGMGFPG-EGPLGRPSNLPQSSADAALCKPGGPG 1199
            +G  PG  G PG  GP G   N             G PG
Sbjct: 1390 RGK-PGKDGKPGTPGPAGEKGNKGSKGEPGPAGSDGLPG 1427



 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 80/277 (28%), Positives = 103/277 (37%), Gaps = 46/277 (16%)

Query: 1161 GQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLG-NSMPSVFTDPD 1219
            G+  FPG  G PG+     P  LP          PG PG   S  V G + +P     P 
Sbjct: 49   GEKGFPGPPGSPGQKGFTGPEGLPGPQGPKGF--PGLPGLTGSKGVRGISGLPGFSGSPG 106

Query: 1220 LQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGE 1279
            L     PG TG   + L   +P    S+  Q FP   +PG     G  PG + ++G  G 
Sbjct: 107  LPGT--PGNTG--PYGLVG-VPGCSGSKGEQGFP--GLPGTLGYPGI-PGAAGLKGQKGA 158

Query: 1280 QAPRMGLALPGMGGPGPVGTPDIPLGT--APSMPGH-NPMRPPAFLQ-QGMMGPHHRMMS 1335
             A    + L   G PG  G P  P G    P  PG   P  PP F    G MGP      
Sbjct: 159  PAKEEDIELDAKGDPGLPGAPG-PQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPR----- 212

Query: 1336 PAQSTMPGQPTLMSNPAAAVG--MIPGK-DRGPAGLYTHPGPVGS-------PGMMMSMQ 1385
                           P   +G  +I  K +RG  GL   PGP G+       P     ++
Sbjct: 213  --------------GPKGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLK 258

Query: 1386 GMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            G  G +  +  P    P G+  +   G     PG+PG
Sbjct: 259  GEKGDKGAMGEPGPPGPSGLPGE-SYGSEKGAPGDPG 294



 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 83/301 (27%), Positives = 113/301 (37%), Gaps = 45/301 (14%)

Query: 1153 FPHNGPSGGQGSFPGGMGFPG-EGPLGRP--------------SNLPQSSADAALCKPGG 1197
            FP    S GQ  F G  G PG +GP G P              S LP  S    L  PG 
Sbjct: 53   FPGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGFSGSPGL--PGT 110

Query: 1198 PGGPDSFTVLGNSMPSVFTDPDLQEVI-RPGATGIPEFDLSRIIPSEK----PSQTLQYF 1252
            PG    + ++G  +P        Q     PG  G P    +  +  +K      + ++  
Sbjct: 111  PGNTGPYGLVG--VPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKGAPAKEEDIELD 168

Query: 1253 PRGE--VPGRKQPQG-PG-PGFSHMQGMMGEQAPRMGLALPGMGGP----GPVGTPDIPL 1304
             +G+  +PG   PQG PG PGF    G +G   P      PG  GP    G +G   I  
Sbjct: 169  AKGDPGLPGAPGPQGLPGPPGF---PGPVGPPGPPGFFGFPGAMGPRGPKGHMGERVIGH 225

Query: 1305 GTAPSMPG-HNPMRPPAFLQQGMMGPHHRMMSPAQS------TMPGQPTLMSNPAAAVGM 1357
                 + G   P  PP  +   + GP +R     +         PG P     P  + G 
Sbjct: 226  KGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGEKGDKGAMGEPGPPGPSGLPGESYGS 285

Query: 1358 IPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQG 1417
              G   G  GL   PG  G PG   S +G+ G +    +  +   +G   D+G  GF +G
Sbjct: 286  EKGAP-GDPGLQGKPGKDGVPGFPGS-EGVKGNRGFPGLMGEDGIKGQKGDIGPPGF-RG 342

Query: 1418 P 1418
            P
Sbjct: 343  P 343



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 99/398 (24%), Positives = 140/398 (35%), Gaps = 70/398 (17%)

Query: 1047 LPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHG 1106
            LP  +  PG+      P  +GP  +V +P  S            +   P   G    P G
Sbjct: 98   LPGFSGSPGL---PGTPGNTGPYGLVGVPGCS--------GSKGEQGFPGLPGTLGYP-G 145

Query: 1107 VPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFP 1166
            +P   GL           ++  +  +G  G P G P  Q  P    FP  GP G  G  P
Sbjct: 146  IPGAAGLKGQKGAPAK-EEDIELDAKGDPGLP-GAPGPQGLPGPPGFP--GPVGPPGP-P 200

Query: 1167 GGMGFPGE-GPLGRPSNLPQS----SADAALCKPGGPGGPDSFTVLGNSMPSVFTD---- 1217
            G  GFPG  GP G   ++ +       +  +    GP GP    ++  + P   TD    
Sbjct: 201  GFFGFPGAMGPRGPKGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGE 260

Query: 1218 -PDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGM 1276
              D   +  PG  G          PS  P ++  Y      PG    QG  PG   + G 
Sbjct: 261  KGDKGAMGEPGPPG----------PSGLPGES--YGSEKGAPGDPGLQGK-PGKDGVPGF 307

Query: 1277 MGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSP 1336
             G +  +     PG+ G   +      +G            PP F  +G    +      
Sbjct: 308  PGSEGVKGNRGFPGLMGEDGIKGQKGDIG------------PPGF--RGPTEYYDTYQEK 353

Query: 1337 AQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGL-----YTHPGPVGSPGM--MMSMQGMMG 1389
                 PG P     P  A G  P    GP G+      + PG  G+PG   +   +G  G
Sbjct: 354  GDEGTPGPP----GPRGARG--PQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERG 407

Query: 1390 -PQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF 1426
             P ++ M  P     G A   G+ G    PG PG+++F
Sbjct: 408  RPGKDAMGTPGSP--GCAGSPGLPGSPGPPGPPGDIVF 443



 Score = 36.2 bits (82), Expect = 0.23
 Identities = 29/90 (32%), Positives = 39/90 (43%), Gaps = 15/90 (16%)

Query: 1347 LMSNPAAAVGMIPGKDRGPA---------GLYTHPGPVGSPGMM-----MSMQGMMGPQQ 1392
            L + PAA+ G +  KD+G           G    PGP GSPG         + G  GP+ 
Sbjct: 21   LAAAPAASKGCVC-KDKGQCFCDGAKGEKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKG 79

Query: 1393 NIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
               +P     +G+    G+ GFS  PG PG
Sbjct: 80   FPGLPGLTGSKGVRGISGLPGFSGSPGLPG 109



 Score = 35.8 bits (81), Expect = 0.30
 Identities = 64/253 (25%), Positives = 83/253 (32%), Gaps = 49/253 (19%)

Query: 234  LPQQPPAP-ANQDQNSSQNTRLQPT-PPIPAP--APKPAAPPRPLDRES----PGVENKL 285
            L + PP P  N     ++  R  P  P +P    A   A P  P   E     PG+   +
Sbjct: 1174 LLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGAI 1233

Query: 286  IPSV----GSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEP 341
            IP      G P S     P   GP   P +  +       +     PK PP      G P
Sbjct: 1234 IPGQTGNRGPPGSRGS--PGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPP 1291

Query: 342  PTLG-ENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLD---- 396
              LG     GL   + +                 P  + F G +  G + NPG L     
Sbjct: 1292 GRLGAPGTPGLPGPRGD-----------------PGFQGFPGVK--GEKGNPGFLGSIGP 1332

Query: 397  ----GPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVP----- 447
                GP+  P         +  SL   PGP    G P G QG    P  P  + P     
Sbjct: 1333 PGPIGPKGPPGVRGDPGTLKIISLPGSPGPPGTPGEP-GMQGEPGPPGPPGNLGPCGPRG 1391

Query: 448  -PSMNSQSGTIGP 459
             P  + + GT GP
Sbjct: 1392 KPGKDGKPGTPGP 1404



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 1/70 (1%)

Query: 27   MVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLK 86
            ++ PP +  P G P         G +G       P P   K      +A PGP G+ G +
Sbjct: 1129 LLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQ 1188

Query: 87   NGAGN-GAKG 95
               G+ GA G
Sbjct: 1189 GAKGDRGAPG 1198



 Score = 31.2 bits (69), Expect = 7.5
 Identities = 19/70 (27%), Positives = 29/70 (41%), Gaps = 1/70 (1%)

Query: 36  PSGNPQLDSKFSNQGKQGGSASQSQPSPC-DSKSGGHTPKALPGPGGSMGLKNGAGNGAK 94
           P G   L  +  +QG  G   S   P P   +   G+ P+  PG  G+ G+    G   +
Sbjct: 582 PKGELALSGEKGDQGPPGDPGSPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGE 641

Query: 95  GKGKRERSIS 104
              + E S+S
Sbjct: 642 AGPRGELSVS 651


>gi|89142730 alpha 3 type IV collagen isoform 1 precursor [Homo
            sapiens]
          Length = 1670

 Score =  113 bits (283), Expect = 1e-24
 Identities = 249/963 (25%), Positives = 327/963 (33%), Gaps = 250/963 (25%)

Query: 506  GPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGF 565
            G +GV   P PP +  P    +     P   G        P G   HP   G     PG 
Sbjct: 628  GTQGVPGAPGPPGEAGPRGELSVSTPVPGPPG--------PPGPPGHPGPQGP----PGI 675

Query: 566  AGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDG-RNFPPGQGIFSGPGR-GER-FP 622
             G +  +   P +P P   PG+ G+ +P   P  P G + FP  +G    PG+ GE   P
Sbjct: 676  PGSLG-KCGDPGLPGPDGEPGIPGIGFPG--PPGPKGDQGFPGTKGSLGCPGKMGEPGLP 732

Query: 623  NPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPG--NNPIFPRI 680
               GL          E  + +P G    G  P    N     S  H E G    P  P  
Sbjct: 733  GKPGLPGAK-----GEPAVAMPGGPGTPGF-PGERGN-----SGEHGEIGLPGLPGLPGT 781

Query: 681  PVEGPLSPSRGDFPKGIPP--QMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMR 738
            P    L   RGD  +  PP  Q  PGR +E    P G +G   LN   G       Q+ R
Sbjct: 782  PGNEGLDGPRGDPGQPGPPGEQGPPGRCIEG---PRGAQGLPGLNGLKG-------QQGR 831

Query: 739  EAGAGPEEMLKLR-------PG--GSDMLPAQQ-KMVPLPFGEHPQQEYGMGPRPFLPMS 788
                GP+    +        PG  GS  +P  Q +M PL    +P     +GP       
Sbjct: 832  RGKTGPKGDPGIPGLDRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNPGILGP------- 884

Query: 789  QGPGSNS--GLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPL 846
              PG +   G+      IGP           P  P NP +         P QRG      
Sbjct: 885  --PGEDGVIGMMGFPGAIGP-----------PGPPGNPGT---------PGQRG------ 916

Query: 847  DISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIK 906
                      SPGI  +K     Q  +P      G+  +P  PS+++ ++         K
Sbjct: 917  ----------SPGIPGVKG----QRGTPGAKGEQGDKGNPG-PSEISHVIGD-------K 954

Query: 907  SPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVE 966
              P L   A +P    +  +P                PG+      P     P   G++ 
Sbjct: 955  GEPGLKGFAGNPGEKGNRGVPG--------------MPGLKGLKGLPGPAGPPGPRGDLG 1000

Query: 967  SGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYH 1026
            S G P     +P    IPGS                          M    MP S     
Sbjct: 1001 STGNP----GEPGLRGIPGS--------------------------MGNMGMPGS----- 1025

Query: 1027 DAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRIS-GPNPVVPMPTLSPMGMTQP 1085
               K    +      A  P LP ++ + G   +   P  S G  P  P PT  P G+   
Sbjct: 1026 ---KGKRGTLGFPGRAGRPGLPGIHGLQG---DKGEPGYSEGTRPGPPGPTGDP-GLPGD 1078

Query: 1086 LSHSNQMPSPNAVGPNIP--PHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQ---- 1139
            +    +M  P   G   P  P G P  PG          G    P  P G +GF      
Sbjct: 1079 MGKKGEMGQPGPPGHLGPAGPEGAPGSPG--------SPGLPGKPG-PHGDLGFKGIKGL 1129

Query: 1140 -GFPPVQSPPQQVPFPHN-GPSG-----GQGSFPGGMGFPGEGPLGRPSNLPQSSADAAL 1192
             G P ++ PP    FP + GP G     G+   PG  G  GE  L R    P+ +  A  
Sbjct: 1130 LGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQG 1189

Query: 1193 CK-----PGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEK-PS 1246
             K     PG PG P     +G++ P              G TGI  F     +P    P 
Sbjct: 1190 AKGDRGAPGFPGLPGRKGAMGDAGPR-------------GPTGIEGFPGPPGLPGAIIPG 1236

Query: 1247 QTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGT 1306
            QT    P G       P  PGP  SH+ G+ G++          MG PGP G P    GT
Sbjct: 1237 QTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKG--------SMGHPGPKGPP----GT 1284

Query: 1307 APSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPG---QPTLMSNPAAAVGMIPGKDR 1363
            A                 G MGP  R+ +P    +PG    P     P      + G+  
Sbjct: 1285 A-----------------GDMGPPGRLGAPGTPGLPGPRGDPGFQGFPG-----VKGEKG 1322

Query: 1364 GPA--GLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNP 1421
             P   G    PGP+G  G    ++G  G  + I +P    P G   + GM G    PG P
Sbjct: 1323 NPGFLGSIGPPGPIGPKGPP-GVRGDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPPGPP 1381

Query: 1422 GNM 1424
            GN+
Sbjct: 1382 GNL 1384



 Score =  110 bits (276), Expect = 7e-24
 Identities = 251/990 (25%), Positives = 332/990 (33%), Gaps = 199/990 (20%)

Query: 516  PPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGS--QMRLPGFAGMINSE- 572
            P +  +P     PG T P+   + +P     +G    P +PG+     +PG AG+   + 
Sbjct: 99   PGFSGSPGLPGTPGNTGPYGL-VGVPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKG 157

Query: 573  ---MEGPNVPNPASRPGLSGVSWPDDVPKIPD--GRNFPPGQ-GIFSGPGR-GERFPNPQ 625
                E     +    PGL G   P  +P  P   G   PPG  G F  PG  G R P   
Sbjct: 158  APAKEEDIELDAKGDPGLPGAPGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGP--- 214

Query: 626  GLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGP 685
                   +  + E+ +G      ++G+                  P   P    + + GP
Sbjct: 215  -------KGHMGERVIGHKGERGVKGLTG----------------PPGPPGTVIVTLTGP 251

Query: 686  -----LSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNS--------QM 732
                 L   +GD  KG   + GP         PSG+ G+     + GS          Q 
Sbjct: 252  DNRTDLKGEKGD--KGAMGEPGPPG-------PSGLPGE-----SYGSEKGAPGDPGLQG 297

Query: 733  IPQKMREAGAGPEEMLKLRPG-----GSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPM 787
             P K    G    E +K   G     G D +  Q+  +  P    P + Y          
Sbjct: 298  KPGKDGVPGFPGSEGVKGNRGFPGLMGEDGIKGQKGDIGPPGFRGPTEYYDTYQEKGDEG 357

Query: 788  SQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLD 847
            + GP    G R  + P GP           P +P +P S+   L  AP      G K   
Sbjct: 358  TPGPPGPRGARGPQGPSGP-----------PGVPGSPGSSRPGLRGAPGWPGLKGSK--- 403

Query: 848  ISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKS 907
                  +   PG + + +P          GSP G   SP  P    G    P      K 
Sbjct: 404  -----GERGRPGKDAMGTP----------GSP-GCAGSPGLPGS-PGPPGPPGDIVFRKG 446

Query: 908  PPVLGSAAASPVHLKSPSLPAPS-----PGWTSSPKPPLQSP-------------GIPPN 949
            PP        P +L SP +P        PG   +  P +  P             GIP  
Sbjct: 447  PP---GDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGLPGLHGVKGIPGR 503

Query: 950  HKAPLTMASPAMLGNVESGGPP--PPTASQPASVNIPG-SLPSSTPYTMPPEPTLSQNPL 1006
              A     SP   GN    G P  P     P      G +L       +P +P L   P 
Sbjct: 504  QGAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQPEGQVGVPGDPGLRGQPG 563

Query: 1007 SIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPAR-----SPNLPSMNNMPGMGINTQ 1061
               +  +         P     +       D  PP       SP        PG G   +
Sbjct: 564  RKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGSPGPAGPAGPPGYGPQGE 623

Query: 1062 NPRISGPNPVVPMPTLSPMGMTQPLSH-SNQMPSPNAVGPNIPP-HGVPMGPGLMSHNPI 1119
             P + G   V   P   P G   P    S   P P   GP  PP H  P GP  +  +  
Sbjct: 624  -PGLQGTQGVPGAP--GPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGS-- 678

Query: 1120 MGHGSQEPPMVPQGRMGFPQ-GFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLG 1178
            +G         P G  G P  GFP    P     FP  G  G  G  PG MG PG    G
Sbjct: 679  LGKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGFP--GTKGSLGC-PGKMGEPGLP--G 733

Query: 1179 RPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIP------ 1232
            +P  LP +  + A+  PGGPG P      GNS        +  E+  PG  G+P      
Sbjct: 734  KPG-LPGAKGEPAVAMPGGPGTPGFPGERGNS-------GEHGEIGLPGLPGLPGTPGNE 785

Query: 1233 EFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQG-PG-PGFSHMQGMMGEQAPRMGLALPG 1290
              D  R  P +      Q  P   + G +  QG PG  G    QG  G+  P+    +PG
Sbjct: 786  GLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPG 845

Query: 1291 M---GGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTL 1347
            +   G PG  G+P I        PGH          QG MGP        Q   PG P +
Sbjct: 846  LDRSGFPGETGSPGI--------PGH----------QGEMGP------LGQRGYPGNPGI 881

Query: 1348 MSNPA--AAVGMI--PGK--DRGPAGLYTHPGPVGSPGM--------MMSMQGMMGPQQN 1393
            +  P     +GM+  PG     GP G    PG  GSPG+            +G  G + N
Sbjct: 882  LGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGN 941

Query: 1394 IMIPPQMRPRGMAADVGMGGFSQGPGNPGN 1423
                      G   + G+ GF+  PG  GN
Sbjct: 942  PGPSEISHVIGDKGEPGLKGFAGNPGEKGN 971



 Score =  107 bits (267), Expect = 8e-23
 Identities = 309/1274 (24%), Positives = 408/1274 (32%), Gaps = 241/1274 (18%)

Query: 290  GSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLG-ENP 348
            G+PA    +  D  G    P   A  P           P  PP PP   G P  +G   P
Sbjct: 157  GAPAKEEDIELDAKGDPGLPG--APGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGP 214

Query: 349  DG-LSQEQLEHR-ERSLQTLRD--------IQRMLFPDEKEFTGAQSG-----------G 387
             G + +  + H+ ER ++ L          I  +  PD +     + G           G
Sbjct: 215  KGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGEKGDKGAMGEPGPPG 274

Query: 388  PQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVP 447
            P   PG   G +K   G           L   PG     G P G +G +     P  M  
Sbjct: 275  PSGLPGESYGSEKGAPG--------DPGLQGKPGKDGVPGFP-GSEGVKGNRGFPGLMGE 325

Query: 448  PSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGP 507
              +  Q G IGP      T           E+Y+  + K ++        +     Q GP
Sbjct: 326  DGIKGQKGDIGPPGFRGPT-----------EYYDTYQEKGDEGTPGPPGPRGARGPQ-GP 373

Query: 508  RGVVRGPPPPYQMTPSEGWAPGGT----------EPFSDGINMPHSLPPRGMAPHPNMPG 557
             G    P  P    P    APG             P  D +  P S    G A  P +PG
Sbjct: 374  SGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGS---PGCAGSPGLPG 430

Query: 558  S------------------QMRLPGFAGMINSE-MEGPN------------VPNPASRPG 586
            S                     LPG+ G      ++GP             +P P   PG
Sbjct: 431  SPGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPG 490

Query: 587  LSGVSWPDDVPK------IPDGRNFPPGQGIFSGPGRGERFPNPQG---LSEEMFQQQLA 637
            L G+     +P       +      P   G+   PG    FP  QG   L  E  +    
Sbjct: 491  LPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPG----FPGAQGDPGLKGEKGETLQP 546

Query: 638  EKQLGLP--PGM-------AMEGIR--------PSMEMNRMIPGSQRHMEPGNNPIFPRI 680
            E Q+G+P  PG+        ++GI         P  +    + G +    P  +P  P  
Sbjct: 547  EGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGS 606

Query: 681  PVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREA 740
            P  GP  P+    P G  PQ  PG +   G+   G  G        G  S   P      
Sbjct: 607  P--GPAGPAG---PPGYGPQGEPGLQGTQGV--PGAPGPPGEAGPRGELSVSTPVPGPPG 659

Query: 741  GAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNL 800
              GP       P G   +P        P    P  E G+ P    P   GP  + G    
Sbjct: 660  PPGPPG--HPGPQGPPGIPGSLGKCGDPGLPGPDGEPGI-PGIGFPGPPGPKGDQGFPGT 716

Query: 801  REPIG-PDQRTNSRLSHMPPLPLNPSSNPTSLNTAP-----PVQRGLGRKPLDISVAG-- 852
            +  +G P +     L   P LP        ++   P     P +RG   +  +I + G  
Sbjct: 717  KGSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLP 776

Query: 853  SQVHSPGINPLKSPTMHQVQSPMLGS---PSGNLKSPQTPSQLAGMLA-----GPAAAAS 904
                +PG   L  P     Q    G    P   ++ P+    L G+       G      
Sbjct: 777  GLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTG 836

Query: 905  IKSPPVLGSAAAS--PVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPA-- 960
             K  P +     S  P    SP +P            PL   G P N   P  +  P   
Sbjct: 837  PKGDPGIPGLDRSGFPGETGSPGIPGHQ-----GEMGPLGQRGYPGN---PGILGPPGED 888

Query: 961  ----MLGNVESGGPPPP-----TASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMS 1011
                M+G   + GPP P     T  Q  S  IPG            E     NP     S
Sbjct: 889  GVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPGP---S 945

Query: 1012 RMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGP--- 1068
             +S        P     +K  A +  +      P +P +  + G+      P   G    
Sbjct: 946  EISHVIGDKGEP----GLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGPPGPRGDLGS 1001

Query: 1069 --NPVVP----MP-TLSPMGMTQPLSHSNQMPSPNAVG-PNIPP-HGVPMGPGLMSHNPI 1119
              NP  P    +P ++  MGM         +  P   G P +P  HG+    G     P 
Sbjct: 1002 TGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGIHGLQGDKG----EPG 1057

Query: 1120 MGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPG-EGPLG 1178
               G++  P  P G  G P          Q  P  H GP+G +G+ PG  G PG  G  G
Sbjct: 1058 YSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGA-PGSPGSPGLPGKPG 1116

Query: 1179 RPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIP-EFDLS 1237
               +L        L  PG  G P      G+  P        ++ I PG  G   E  L 
Sbjct: 1117 PHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGI-PGPAGEKGETGLL 1175

Query: 1238 RIIPSEKPSQTLQYFPRGEVPGRKQPQG----PG-PGFSHMQGMMGEQAPRMGLALPGMG 1292
            R  P           PRG  PG +  +G    PG PG    +G MG+  PR    + G  
Sbjct: 1176 RAPPG----------PRGN-PGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEGF- 1223

Query: 1293 GPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPA 1352
             PGP G P         +PG          Q G  GP      P     PG P     P 
Sbjct: 1224 -PGPPGLP------GAIIPG----------QTGNRGP------PGSRGSPGAPGPPGPPG 1260

Query: 1353 AAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMG 1412
            + V  I G D+G  G   HPGP G PG      G MGP   +  P      G   D G  
Sbjct: 1261 SHVIGIKG-DKGSMG---HPGPKGPPGTA----GDMGPPGRLGAPGTPGLPGPRGDPGFQ 1312

Query: 1413 GFSQGPGNPGNMMF 1426
            GF    G  GN  F
Sbjct: 1313 GFPGVKGEKGNPGF 1326



 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 192/808 (23%), Positives = 260/808 (32%), Gaps = 162/808 (20%)

Query: 254  LQPTPPIPAPAPKPAAPPRPLDRESPGVENKL-------IP----SVGSPASSTPLPPDG 302
            L  + P+P P   P  P  P  +  PG+   L       +P      G P    P PP  
Sbjct: 648  LSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFPGPPGP 707

Query: 303  TGPNSTPNNRAVTPVSQGSNSSSADPKAPPPP--PVSSGEPPTL---GENPDGLSQEQLE 357
             G    P  +     S G      +P  P  P  P + GEP      G    G   E+  
Sbjct: 708  KGDQGFPGTKG----SLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGN 763

Query: 358  HRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQ--NPGVLDGPQKKPEGP--------IQ 407
              E     L  +  +      E      G P Q   PG    P +  EGP        + 
Sbjct: 764  SGEHGEIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLN 823

Query: 408  AMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTP 467
             +  Q    GK  GP+ D G P       D    P E   P +    G +GP        
Sbjct: 824  GLKGQQGRRGK-TGPKGDPGIP-----GLDRSGFPGETGSPGIPGHQGEMGP-------- 869

Query: 468  EQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM-TPSEGW 526
                   L Q  Y           +     +D ++   G  G +  P PP    TP +  
Sbjct: 870  -------LGQRGYPGNPG------ILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRG 916

Query: 527  APG-----------------------GTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLP 563
            +PG                       G    S  I        +G A +P   G++  +P
Sbjct: 917  SPGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNR-GVP 975

Query: 564  GFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFP--------PG----QGI 611
            G  G+   +     +P PA  PG  G       P  P  R  P        PG    +G 
Sbjct: 976  GMPGLKGLK----GLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGT 1031

Query: 612  FSGPGRGER--FPNPQGLSEEMFQQQLAEKQLGLPPGMAME-GIRPSM----EMNRMIPG 664
               PGR  R   P   GL  +  +   +E     PPG   + G+   M    EM +  PG
Sbjct: 1032 LGFPGRAGRPGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQ--PG 1089

Query: 665  SQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMV-----PSGMKGD 719
               H+ P         P   P SP       G+P + GP  +L F  +     P G++G 
Sbjct: 1090 PPGHLGPAG-------PEGAPGSPG----SPGLPGKPGPHGDLGFKGIKGLLGPPGIRGP 1138

Query: 720  VNLNVNMGSNSQM--IPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEY 777
              L    GS   M     + R+   GP        G + +L A       P  +  + + 
Sbjct: 1139 PGLPGFPGSPGPMGIRGDQGRDGIPGPAG----EKGETGLLRAPPGPRGNPGAQGAKGDR 1194

Query: 778  GMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSS--NPTSLNTAP 835
            G    P LP  +G   ++G      P GP     + +   P  P  P +     + N  P
Sbjct: 1195 GAPGFPGLPGRKGAMGDAG------PRGP-----TGIEGFPGPPGLPGAIIPGQTGNRGP 1243

Query: 836  PVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGS-----PSGNLKSPQTPS 890
            P  RG    P      GS  H  GI   K    H       G+     P G L +P TP 
Sbjct: 1244 PGSRGSPGAPGPPGPPGS--HVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLGAPGTPG 1301

Query: 891  QLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAP-----SPGWTSSPKPPLQSPG 945
                 L GP      +  P +     +P  L S   P P      PG    P   L+   
Sbjct: 1302 -----LPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRGDP-GTLKIIS 1355

Query: 946  IPPNHKAPLTMASPAMLGNVESGGPPPP 973
            +P +   P T   P M G  E G P PP
Sbjct: 1356 LPGSPGPPGTPGEPGMQG--EPGPPGPP 1381



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 239/999 (23%), Positives = 307/999 (30%), Gaps = 209/999 (20%)

Query: 260  IPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPV-- 317
            +P P  + A      D+  PG       S GSP  + P  P G GP   P  +    V  
Sbjct: 579  LPGPKGELALSGEKGDQGPPGDPG----SPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPG 634

Query: 318  ---------SQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRD 368
                      +G  S S     PP PP   G P   G  P G+     +  +  L     
Sbjct: 635  APGPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQG--PPGIPGSLGKCGDPGLPG--- 689

Query: 369  IQRMLFPD-EKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKG--PGPRTD 425
                  PD E    G    GP    G    P  K        M +    GK   PG + +
Sbjct: 690  ------PDGEPGIPGIGFPGPPGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGE 743

Query: 426  --VGAPFGP-----QGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHM-----TPEQIAWL 473
              V  P GP      G R       E+  P +    GT G + LD        P      
Sbjct: 744  PAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQ 803

Query: 474  KLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEP 533
                   E  R  Q    +     Q     + GP+G    P       P E  +PG   P
Sbjct: 804  GPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGSPG--IP 861

Query: 534  FSDGINMPHSLPPRGMAPHPNMPG--------SQMRLPGFAGMINSEMEGPNVPNPASRP 585
               G      + P G   +P  PG          + + GF G I     GP  P P   P
Sbjct: 862  GHQG-----EMGPLGQRGYPGNPGILGPPGEDGVIGMMGFPGAI-----GP--PGPPGNP 909

Query: 586  GLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPP 645
            G  G      +P +   R  P  +G     G     P P  +S  +  +          P
Sbjct: 910  GTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGN----PGPSEISHVIGDKG--------EP 957

Query: 646  GMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGR 705
            G+      P  + NR +PG      PG   +                  KG+P   G   
Sbjct: 958  GLKGFAGNPGEKGNRGVPGM-----PGLKGL------------------KGLPGPAG--- 991

Query: 706  ELEFGMVPSGMKGDVNLNVNMGS-NSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKM 764
                   P G +GD+    N G    + IP  M   G    +  +    G+   P +   
Sbjct: 992  -------PPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKR----GTLGFPGRAGR 1040

Query: 765  VPLP-----FGEHPQQEYGMGPRPFLPMSQG----PGSNSGLRNLREPIGPDQRTNSRLS 815
              LP      G+  +  Y  G RP  P   G    PG       + +P GP         
Sbjct: 1041 PGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQP-GPPGHLG---- 1095

Query: 816  HMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPM 875
                 P  P   P S     P   GL  KP      G +    GI  L  P       P 
Sbjct: 1096 -----PAGPEGAPGS-----PGSPGLPGKPGPHGDLGFK----GIKGLLGP-------PG 1134

Query: 876  LGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTS 935
            +  P G    P +P  +   + G      I  P   G    + + L++P  P  +PG   
Sbjct: 1135 IRGPPGLPGFPGSPGPMG--IRGDQGRDGIPGP--AGEKGETGL-LRAPPGPRGNPG-AQ 1188

Query: 936  SPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQ--PASVNIPGS-LPSSTP 992
              K    +PG P           P   G +   GP  PT  +  P    +PG+ +P  T 
Sbjct: 1189 GAKGDRGAPGFP---------GLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGAIIPGQTG 1239

Query: 993  YTMPPEPTLSQNPLSIMMSRMSKFAM-PSSTPLYH-DAIKTVASSDDDSPPARSPNLPSM 1050
               PP             SR S  A  P   P  H   IK    S     P   P     
Sbjct: 1240 NRGPPG------------SRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGD 1287

Query: 1051 NNMPGMGINTQNPRISGP-NPVVPMPTLSP--------MGMTQPLSHSNQMPSPNAVGPN 1101
               PG        R+  P  P +P P   P         G          +  P  +GP 
Sbjct: 1288 MGPPG--------RLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPK 1339

Query: 1102 IPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGG 1161
             PP GV   PG +    I   GS  PP  P G  G  QG P    PP  +     GP G 
Sbjct: 1340 GPP-GVRGDPGTL--KIISLPGSPGPPGTP-GEPGM-QGEPGPPGPPGNL-----GPCGP 1389

Query: 1162 QGSFPGGMGFPG-EGPLGRPSNLPQSSADAALCKPGGPG 1199
            +G  PG  G PG  GP G   N             G PG
Sbjct: 1390 RGK-PGKDGKPGTPGPAGEKGNKGSKGEPGPAGSDGLPG 1427



 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 80/277 (28%), Positives = 103/277 (37%), Gaps = 46/277 (16%)

Query: 1161 GQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLG-NSMPSVFTDPD 1219
            G+  FPG  G PG+     P  LP          PG PG   S  V G + +P     P 
Sbjct: 49   GEKGFPGPPGSPGQKGFTGPEGLPGPQGPKGF--PGLPGLTGSKGVRGISGLPGFSGSPG 106

Query: 1220 LQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGE 1279
            L     PG TG   + L   +P    S+  Q FP   +PG     G  PG + ++G  G 
Sbjct: 107  LPGT--PGNTG--PYGLVG-VPGCSGSKGEQGFP--GLPGTLGYPGI-PGAAGLKGQKGA 158

Query: 1280 QAPRMGLALPGMGGPGPVGTPDIPLGT--APSMPGH-NPMRPPAFLQ-QGMMGPHHRMMS 1335
             A    + L   G PG  G P  P G    P  PG   P  PP F    G MGP      
Sbjct: 159  PAKEEDIELDAKGDPGLPGAPG-PQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPR----- 212

Query: 1336 PAQSTMPGQPTLMSNPAAAVG--MIPGK-DRGPAGLYTHPGPVGS-------PGMMMSMQ 1385
                           P   +G  +I  K +RG  GL   PGP G+       P     ++
Sbjct: 213  --------------GPKGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLK 258

Query: 1386 GMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            G  G +  +  P    P G+  +   G     PG+PG
Sbjct: 259  GEKGDKGAMGEPGPPGPSGLPGE-SYGSEKGAPGDPG 294



 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 83/301 (27%), Positives = 113/301 (37%), Gaps = 45/301 (14%)

Query: 1153 FPHNGPSGGQGSFPGGMGFPG-EGPLGRP--------------SNLPQSSADAALCKPGG 1197
            FP    S GQ  F G  G PG +GP G P              S LP  S    L  PG 
Sbjct: 53   FPGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGFSGSPGL--PGT 110

Query: 1198 PGGPDSFTVLGNSMPSVFTDPDLQEVI-RPGATGIPEFDLSRIIPSEK----PSQTLQYF 1252
            PG    + ++G  +P        Q     PG  G P    +  +  +K      + ++  
Sbjct: 111  PGNTGPYGLVG--VPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKGAPAKEEDIELD 168

Query: 1253 PRGE--VPGRKQPQG-PG-PGFSHMQGMMGEQAPRMGLALPGMGGP----GPVGTPDIPL 1304
             +G+  +PG   PQG PG PGF    G +G   P      PG  GP    G +G   I  
Sbjct: 169  AKGDPGLPGAPGPQGLPGPPGF---PGPVGPPGPPGFFGFPGAMGPRGPKGHMGERVIGH 225

Query: 1305 GTAPSMPG-HNPMRPPAFLQQGMMGPHHRMMSPAQS------TMPGQPTLMSNPAAAVGM 1357
                 + G   P  PP  +   + GP +R     +         PG P     P  + G 
Sbjct: 226  KGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGEKGDKGAMGEPGPPGPSGLPGESYGS 285

Query: 1358 IPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQG 1417
              G   G  GL   PG  G PG   S +G+ G +    +  +   +G   D+G  GF +G
Sbjct: 286  EKGAP-GDPGLQGKPGKDGVPGFPGS-EGVKGNRGFPGLMGEDGIKGQKGDIGPPGF-RG 342

Query: 1418 P 1418
            P
Sbjct: 343  P 343



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 99/398 (24%), Positives = 140/398 (35%), Gaps = 70/398 (17%)

Query: 1047 LPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHG 1106
            LP  +  PG+      P  +GP  +V +P  S            +   P   G    P G
Sbjct: 98   LPGFSGSPGL---PGTPGNTGPYGLVGVPGCS--------GSKGEQGFPGLPGTLGYP-G 145

Query: 1107 VPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFP 1166
            +P   GL           ++  +  +G  G P G P  Q  P    FP  GP G  G  P
Sbjct: 146  IPGAAGLKGQKGAPAK-EEDIELDAKGDPGLP-GAPGPQGLPGPPGFP--GPVGPPGP-P 200

Query: 1167 GGMGFPGE-GPLGRPSNLPQS----SADAALCKPGGPGGPDSFTVLGNSMPSVFTD---- 1217
            G  GFPG  GP G   ++ +       +  +    GP GP    ++  + P   TD    
Sbjct: 201  GFFGFPGAMGPRGPKGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGE 260

Query: 1218 -PDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGM 1276
              D   +  PG  G          PS  P ++  Y      PG    QG  PG   + G 
Sbjct: 261  KGDKGAMGEPGPPG----------PSGLPGES--YGSEKGAPGDPGLQGK-PGKDGVPGF 307

Query: 1277 MGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSP 1336
             G +  +     PG+ G   +      +G            PP F  +G    +      
Sbjct: 308  PGSEGVKGNRGFPGLMGEDGIKGQKGDIG------------PPGF--RGPTEYYDTYQEK 353

Query: 1337 AQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGL-----YTHPGPVGSPGM--MMSMQGMMG 1389
                 PG P     P  A G  P    GP G+      + PG  G+PG   +   +G  G
Sbjct: 354  GDEGTPGPP----GPRGARG--PQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERG 407

Query: 1390 -PQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF 1426
             P ++ M  P     G A   G+ G    PG PG+++F
Sbjct: 408  RPGKDAMGTPGSP--GCAGSPGLPGSPGPPGPPGDIVF 443



 Score = 36.2 bits (82), Expect = 0.23
 Identities = 29/90 (32%), Positives = 39/90 (43%), Gaps = 15/90 (16%)

Query: 1347 LMSNPAAAVGMIPGKDRGPA---------GLYTHPGPVGSPGMM-----MSMQGMMGPQQ 1392
            L + PAA+ G +  KD+G           G    PGP GSPG         + G  GP+ 
Sbjct: 21   LAAAPAASKGCVC-KDKGQCFCDGAKGEKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKG 79

Query: 1393 NIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
               +P     +G+    G+ GFS  PG PG
Sbjct: 80   FPGLPGLTGSKGVRGISGLPGFSGSPGLPG 109



 Score = 35.8 bits (81), Expect = 0.30
 Identities = 64/253 (25%), Positives = 83/253 (32%), Gaps = 49/253 (19%)

Query: 234  LPQQPPAP-ANQDQNSSQNTRLQPT-PPIPAP--APKPAAPPRPLDRES----PGVENKL 285
            L + PP P  N     ++  R  P  P +P    A   A P  P   E     PG+   +
Sbjct: 1174 LLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGAI 1233

Query: 286  IPSV----GSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEP 341
            IP      G P S     P   GP   P +  +       +     PK PP      G P
Sbjct: 1234 IPGQTGNRGPPGSRGS--PGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPP 1291

Query: 342  PTLG-ENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLD---- 396
              LG     GL   + +                 P  + F G +  G + NPG L     
Sbjct: 1292 GRLGAPGTPGLPGPRGD-----------------PGFQGFPGVK--GEKGNPGFLGSIGP 1332

Query: 397  ----GPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVP----- 447
                GP+  P         +  SL   PGP    G P G QG    P  P  + P     
Sbjct: 1333 PGPIGPKGPPGVRGDPGTLKIISLPGSPGPPGTPGEP-GMQGEPGPPGPPGNLGPCGPRG 1391

Query: 448  -PSMNSQSGTIGP 459
             P  + + GT GP
Sbjct: 1392 KPGKDGKPGTPGP 1404



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 1/70 (1%)

Query: 27   MVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLK 86
            ++ PP +  P G P         G +G       P P   K      +A PGP G+ G +
Sbjct: 1129 LLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQ 1188

Query: 87   NGAGN-GAKG 95
               G+ GA G
Sbjct: 1189 GAKGDRGAPG 1198



 Score = 31.2 bits (69), Expect = 7.5
 Identities = 19/70 (27%), Positives = 29/70 (41%), Gaps = 1/70 (1%)

Query: 36  PSGNPQLDSKFSNQGKQGGSASQSQPSPC-DSKSGGHTPKALPGPGGSMGLKNGAGNGAK 94
           P G   L  +  +QG  G   S   P P   +   G+ P+  PG  G+ G+    G   +
Sbjct: 582 PKGELALSGEKGDQGPPGDPGSPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGE 641

Query: 95  GKGKRERSIS 104
              + E S+S
Sbjct: 642 AGPRGELSVS 651


>gi|116256356 alpha 4 type IV collagen precursor [Homo sapiens]
          Length = 1690

 Score =  112 bits (281), Expect = 2e-24
 Identities = 311/1246 (24%), Positives = 415/1246 (33%), Gaps = 303/1246 (24%)

Query: 258  PPIPAPAP-KPAAPPRPLDRESPGVE-----NKLIPSVGSPA----SSTPLPPDGTGPNS 307
            P  P  AP KP  P  P    +PG++     + +  SVG+P          PP G GP  
Sbjct: 425  PGRPDSAPGKPGKPGSPGLPGAPGLQGLPGSSVIYCSVGNPGPQGIKGKVGPPGGRGPKG 484

Query: 308  TPNNRAVT---------------PVSQGSNSSSADP-----KAPPPPPVSSGEPPTLGEN 347
               N  +                P  QGS      P     K  P PP + G P   G++
Sbjct: 485  EKGNEGLCACEPGPMGPPGPPGLPGRQGSKGDLGLPGWLGTKGDPGPPGAEGPPGLPGKH 544

Query: 348  -PDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPI 406
               G    +    +  +  ++  +    PD       Q G   ++    +     P G  
Sbjct: 545  GASGPPGNKGAKGDMVVSRVKGHKGERGPDGPPGFPGQPGSHGRDGHAGEKGDPGPPGDH 604

Query: 407  QAMMAQSQSLGKG-PGPRTDVG--APFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLD 463
            +     +   GKG PGP    G   P GP G    P  P E   P +    G  GPD L 
Sbjct: 605  E----DATPGGKGFPGPLGPPGKAGPVGPPG-LGFPGPPGERGHPGVPGHPGVRGPDGLK 659

Query: 464  HMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPS 523
                + I+                       C++      +HGP G   GPP P      
Sbjct: 660  GQKGDTIS-----------------------CNVT--YPGRHGPPGF-DGPPGPKGFPGP 693

Query: 524  EGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPG--SQMRLPGFAGMINSEMEGPNVPNP 581
            +G APG +   SDG       P  G A  P  PG    M  PGF G   S   GP  P P
Sbjct: 694  QG-APGLSG--SDGHKGRPGTP--GTAEIPGPPGFRGDMGDPGFGGEKGSSPVGP--PGP 746

Query: 582  ASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSG-PG----RGERFPNPQGLSEEMFQQQL 636
               PG++G       P    G   PPG+   SG PG    RG+  P   G          
Sbjct: 747  PGSPGVNGQKGIPGDPAF--GHLGPPGKRGLSGVPGIKGPRGD--PGCPG---------- 792

Query: 637  AEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKG 696
            AE   G+P  + ++G +          G + H        FP +P  GP   S      G
Sbjct: 793  AEGPAGIPGFLGLKGPK----------GREGHAG------FPGVP--GPPGHSCERGAPG 834

Query: 697  IPPQMG-PGRELEFGMVPS-GMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGG 754
            IP Q G PG     G     G  GDV                      GP       P G
Sbjct: 835  IPGQPGLPGYPGSPGAPGGKGQPGDV----------------------GPPG-----PAG 867

Query: 755  SDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRL 814
               LP     +P   G H       GP P LP   GP  + GL     P GP  R     
Sbjct: 868  MKGLPG----LPGRPGAH-------GP-PGLPGIPGPFGDDGLPGPPGPKGP--RGLPGF 913

Query: 815  SHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQ--VHSPGINPLKSPTMHQVQ 872
               P     P +         P ++G+   P D  + G++  +  PG +  +   + Q  
Sbjct: 914  PGFPGERGKPGAEGCPGAKGEPGEKGMSGLPGDRGLRGAKGAIGPPG-DEGEMAIISQKG 972

Query: 873  SPMLGSPSGNLKSP-QTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAP-S 930
            +P    P G+   P +   +    + G         PP  G     P     P  P P  
Sbjct: 973  TPGEPGPPGDDGFPGERGDKGTPGMQGRRGEPGRYGPP--GFHRGEPGEKGQPGPPGPPG 1030

Query: 931  PGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGP------------PPPTASQP 978
            P  ++  +  +  PG+P +   P +   P   G   + GP            PP    +P
Sbjct: 1031 PPGSTGLRGFIGFPGLPGDQGEPGSPGPPGFSGIDGARGPKGNKGDPASHFGPPGPKGEP 1090

Query: 979  ASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDD 1038
             S   PG   +S    +P      Q P                            S    
Sbjct: 1091 GSPGCPGHFGASGEQGLPG----IQGPRG--------------------------SPGRP 1120

Query: 1039 SPPARS--PNLPSMNNMPGM-------------GINTQNPRISGPNPVVPMPTLSPMGMT 1083
             PP  S  P  P  + MPG+             G+   +P I GP P +  P+ SP G+ 
Sbjct: 1121 GPPGSSGPPGCPGDHGMPGLRGQPGEMGDPGPRGLQG-DPGIPGP-PGIKGPSGSP-GLN 1177

Query: 1084 QPLSHSNQMPSPNAVG-PNIPPHGVPMG-PGLMSHNPIMGHGSQEPPMVPQGRMGFPQGF 1141
                   Q  +  A G  ++ P G P+G PGL       G     PP  P+G+ G P G 
Sbjct: 1178 GLHGLKGQKGTKGASGLHDVGPPG-PVGIPGLKGERGDPGSPGISPPG-PRGKKG-PPGP 1234

Query: 1142 PPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGP 1201
            P    PP        GP+G  G  P  +  PG      P +      D     PG PG P
Sbjct: 1235 PGSSGPP--------GPAGATGRAPKDIPDPGP-----PGDQGPPGPDGPRGAPGPPGLP 1281

Query: 1202 DSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRK 1261
             S  +L                  PG  G+P                         PG  
Sbjct: 1282 GSVDLLRGE---------------PGDCGLPG-----------------------PPGPP 1303

Query: 1262 QPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGP----GPVGTPDIPLGTAPSMPGHNPMR 1317
             P GP PG+    G  G+   +  +  PG  GP    GP G   +P    P   G   + 
Sbjct: 1304 GPPGP-PGYKGFPGCDGKDGQKGPVGFPGPQGPHGFPGPPGEKGLP--GPPGRKGPTGLP 1360

Query: 1318 PPAFLQQGMMGPHHRMMS-PAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVG 1376
             P    +G  GP   +   P    +PG P  M  P  A+G+ PG  RGP+G    PG  G
Sbjct: 1361 GP----RGEPGPPADVDDCPRIPGLPGAPG-MRGPEGAMGL-PGM-RGPSG----PGCKG 1409

Query: 1377 SPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
             PG+    +G+ G      +P    P G   D G  G+  GPG PG
Sbjct: 1410 EPGLD-GRRGVDG------VPGSPGPPGRKGDTGEDGYPGGPGPPG 1448



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 127/461 (27%), Positives = 162/461 (35%), Gaps = 130/461 (28%)

Query: 1068 PNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGP--------NIPPHGVPMGPGLMSHNPI 1119
            P P  P   + P+G   P+  S +       GP        +  P GVP  PGL   + I
Sbjct: 67   PGPPGPQGPIGPLGAPGPIGLSGEKGMRGDRGPPGAAGDKGDKGPTGVPGFPGL---DGI 123

Query: 1120 MGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGE-GPLG 1178
             GH     P  P+G+ G                  HNG  G  G FPGG G  G  GPLG
Sbjct: 124  PGHPG---PPGPRGKPGMSG---------------HNGSRGDPG-FPGGRGALGPGGPLG 164

Query: 1179 RPSNLPQSSADAALC-----------KPGGPGGPDSFTVLGNSMPSVFT-DPDL----QE 1222
             P    +      +             PG PG P S+   G + P+ +  +P L     +
Sbjct: 165  HPGEKGEKGNSVFILGAVKGIQGDRGDPGLPGLPGSWGAGGPAGPTGYPGEPGLVGPPGQ 224

Query: 1223 VIRPGATGIPEF-------DLSRIIPSEKPSQTLQYFP------RGE------------- 1256
              RPG  G P         D   +     P  TL   P      +GE             
Sbjct: 225  PGRPGLKGNPGVGVKGQMGDPGEVGQQGSPGPTLLVEPPDFCLYKGEKGIKGIPGMVGLP 284

Query: 1257 -VPGRKQPQGPG----------------------PGFSHMQGMMG--EQAPRMGLALP-- 1289
              PGRK   G G                      PGF  ++G +G        GL  P  
Sbjct: 285  GPPGRKGESGIGAKGEKGIPGFPGPRGDPGSYGSPGFPGLKGELGLVGDPGLFGLIGPKG 344

Query: 1290 ---GMGGPGPVG---TPDIPLGTAPSMPGH----------NPMRPPAFLQQ------GMM 1327
                 G PGP G   TP +PL   P  PG            P  PP  L +      GM+
Sbjct: 345  DPGNRGHPGPPGVLVTPPLPLKGPPGDPGFPGRYGETGDVGPPGPPGLLGRPGEACAGMI 404

Query: 1328 GPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPG--MMMSMQ 1385
            GP      P    +PG+  +   P +A G  PGK   P GL   PG  G PG  ++    
Sbjct: 405  GPPGPQGFPGLPGLPGEAGIPGRPDSAPGK-PGKPGSP-GLPGAPGLQGLPGSSVIYCSV 462

Query: 1386 GMMGPQ--QNIMIPPQMR-PRGMAADVGMGGFSQGP-GNPG 1422
            G  GPQ  +  + PP  R P+G   + G+     GP G PG
Sbjct: 463  GNPGPQGIKGKVGPPGGRGPKGEKGNEGLCACEPGPMGPPG 503



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 238/1001 (23%), Positives = 322/1001 (32%), Gaps = 196/1001 (19%)

Query: 495  CSLQDMMVHQHGPRGVVRGPP-PPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHP 553
            C  +D  V    P    RGPP PP    P       G    S    M     P G A   
Sbjct: 47   CGGRDCSVCHCVPEKGSRGPPGPPGPQGPIGPLGAPGPIGLSGEKGMRGDRGPPGAAGDK 106

Query: 554  NMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFS 613
               G    +PGF G+ +     P  P P  +PG+SG +     P       FP G+G   
Sbjct: 107  GDKGPT-GVPGFPGL-DGIPGHPGPPGPRGKPGMSGHNGSRGDP------GFPGGRGAL- 157

Query: 614  GPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGN 673
            GPG       P G   E  ++  +   LG   G+  +   P +     +PGS     P  
Sbjct: 158  GPG------GPLGHPGEKGEKGNSVFILGAVKGIQGDRGDPGLPG---LPGSWGAGGPAG 208

Query: 674  NPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMI 733
               +P  P  G + P         P Q  PGR    G    G+KG +     +G      
Sbjct: 209  PTGYPGEP--GLVGP---------PGQ--PGRPGLKGNPGVGVKGQMGDPGEVGQQGSPG 255

Query: 734  PQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGS 793
            P  + E    P+  L     G   +P    MV LP     + E G+G +    +   PG 
Sbjct: 256  PTLLVEP---PDFCLYKGEKGIKGIPG---MVGLPGPPGRKGESGIGAKGEKGIPGFPGP 309

Query: 794  NSGLRNLREPIGPDQRTNSRLSHMPPL-----PLNPSSN-----PTSLNTAPPVQRGLGR 843
                 +   P  P  +    L   P L     P     N     P  +   PP+   L  
Sbjct: 310  RGDPGSYGSPGFPGLKGELGLVGDPGLFGLIGPKGDPGNRGHPGPPGVLVTPPLP--LKG 367

Query: 844  KPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAA 903
             P D    G    +  + P   P +       LG P             AGM+  P    
Sbjct: 368  PPGDPGFPGRYGETGDVGPPGPPGL-------LGRPG---------EACAGMIGPPGPQG 411

Query: 904  SIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLG 963
                P + G A         P  P  +PG    P  P   PG P     P +      +G
Sbjct: 412  FPGLPGLPGEAGI-------PGRPDSAPGKPGKPGSP-GLPGAPGLQGLPGSSVIYCSVG 463

Query: 964  NVE----SGGPPPPTASQPASVNIPGSLPSSTPYTM-PPEPTLSQNPLSIMMSRMSKFAM 1018
            N       G   PP    P        L +  P  M PP P      L           +
Sbjct: 464  NPGPQGIKGKVGPPGGRGPKGEKGNEGLCACEPGPMGPPGPP----GLPGRQGSKGDLGL 519

Query: 1019 PSSTPLYHDAIKTVASSDDDSPPARS--PNLPSMNNMPGMGINTQNPRISGPNPVVPMPT 1076
            P            + +  D  PP     P LP  +   G              P      
Sbjct: 520  PG----------WLGTKGDPGPPGAEGPPGLPGKHGASG--------------PPGNKGA 555

Query: 1077 LSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMG 1136
               M +++   H  +       GP+ PP G P  PG    +   GH  ++    P G   
Sbjct: 556  KGDMVVSRVKGHKGER------GPDGPP-GFPGQPGSHGRD---GHAGEKGDPGPPG--- 602

Query: 1137 FPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGE-GPLGRPSNLPQSSADAALCKP 1195
                              H   + G   FPG +G PG+ GP+G P  L           P
Sbjct: 603  -----------------DHEDATPGGKGFPGPLGPPGKAGPVG-PPGLGFPGPPGERGHP 644

Query: 1196 GGPG-----GPD------------SFTVLGNSMPSVFTDPDLQEVI--RPGATGIPEFDL 1236
            G PG     GPD            + T  G   P  F  P   +      GA G+   D 
Sbjct: 645  GVPGHPGVRGPDGLKGQKGDTISCNVTYPGRHGPPGFDGPPGPKGFPGPQGAPGLSGSDG 704

Query: 1237 SRIIPSEKPSQTLQYFP--RGEV--PG-----RKQPQGP-----GPGFSHMQGMMGEQA- 1281
             +  P    +  +   P  RG++  PG        P GP      PG +  +G+ G+ A 
Sbjct: 705  HKGRPGTPGTAEIPGPPGFRGDMGDPGFGGEKGSSPVGPPGPPGSPGVNGQKGIPGDPAF 764

Query: 1282 ----PRMGLALPGMGG-PGPVGTPDIPLGTAPS-MPGHNPMRPPAFLQ-----QGMMGPH 1330
                P     L G+ G  GP G P  P    P+ +PG   ++ P   +      G+ GP 
Sbjct: 765  GHLGPPGKRGLSGVPGIKGPRGDPGCPGAEGPAGIPGFLGLKGPKGREGHAGFPGVPGPP 824

Query: 1331 HRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDR-------GPAGLYTHPGPVGSPGM--M 1381
                      +PGQP L   P +  G   GK +       GPAG+   PG  G PG    
Sbjct: 825  GHSCERGAPGIPGQPGLPGYPGSP-GAPGGKGQPGDVGPPGPAGMKGLPGLPGRPGAHGP 883

Query: 1382 MSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
              + G+ GP  +  +P    P+G     G  GF    G PG
Sbjct: 884  PGLPGIPGPFGDDGLPGPPGPKGPRGLPGFPGFPGERGKPG 924



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 210/880 (23%), Positives = 269/880 (30%), Gaps = 204/880 (23%)

Query: 387  GPQQNPGVL--DGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAP-FGPQGHRDVPFSPD 443
            GPQ  PG+   DG + +P  P  A       +   PG R D+G P FG +        P 
Sbjct: 692  GPQGAPGLSGSDGHKGRPGTPGTA------EIPGPPGFRGDMGDPGFGGEKGSSPVGPPG 745

Query: 444  EMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVH 503
                P +N Q G  G     H+ P               KR       ++          
Sbjct: 746  PPGSPGVNGQKGIPGDPAFGHLGPPG-------------KRGLSGVPGIKGPRGDPGCPG 792

Query: 504  QHGPRGV-----VRGP--------------PPPYQMT------PSEGWAPG--GTEPFSD 536
              GP G+     ++GP              PP +         P +   PG  G+     
Sbjct: 793  AEGPAGIPGFLGLKGPKGREGHAGFPGVPGPPGHSCERGAPGIPGQPGLPGYPGSPGAPG 852

Query: 537  GINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDV 596
            G   P  + P G A    +PG    LPG  G  +     P +P P    GL G   P   
Sbjct: 853  GKGQPGDVGPPGPAGMKGLPG----LPGRPGA-HGPPGLPGIPGPFGDDGLPGPPGPKGP 907

Query: 597  PKIPDGRNFPPGQGIFSGPG----RGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGI 652
              +P    FP  +G     G    +GE  P  +G+S             GLP    + G 
Sbjct: 908  RGLPGFPGFPGERGKPGAEGCPGAKGE--PGEKGMS-------------GLPGDRGLRGA 952

Query: 653  RPSMEMNRMIPGSQRHM---EPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMG----PGR 705
            + ++      PG +  M        P  P  P +      RGD  KG P   G    PGR
Sbjct: 953  KGAIGP----PGDEGEMAIISQKGTPGEPGPPGDDGFPGERGD--KGTPGMQGRRGEPGR 1006

Query: 706  ELEFGM--------------VPSGMKGDVNLNVNMGSNSQMIPQKMREAGA-GPEEMLKL 750
                G                P G  G   L   +G     +P    E G+ GP     +
Sbjct: 1007 YGPPGFHRGEPGEKGQPGPPGPPGPPGSTGLRGFIGFPG--LPGDQGEPGSPGPPGFSGI 1064

Query: 751  ----RPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGP 806
                 P G+   PA     P P GE           P  P   G     GL  ++ P G 
Sbjct: 1065 DGARGPKGNKGDPASHFGPPGPKGEPGS--------PGCPGHFGASGEQGLPGIQGPRGS 1116

Query: 807  DQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSP 866
              R     S  PP        P           GL  +P        ++  PG   L+  
Sbjct: 1117 PGRPGPPGSSGPPGCPGDHGMP-----------GLRGQP-------GEMGDPGPRGLQG- 1157

Query: 867  TMHQVQSPMLGSPSGNLKSPQTPSQLAGM--LAGPAAAASIKSPPVLGSAAASPVHLKSP 924
                   P +  P G +K P     L G+  L G             G+  AS +H   P
Sbjct: 1158 ------DPGIPGPPG-IKGPSGSPGLNGLHGLKGQK-----------GTKGASGLHDVGP 1199

Query: 925  SLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPP---TASQPASV 981
              P   PG       P  SPGI P    P         G   S GPP P   T   P  +
Sbjct: 1200 PGPVGIPGLKGERGDP-GSPGISP----PGPRGKKGPPGPPGSSGPPGPAGATGRAPKDI 1254

Query: 982  NIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPP 1041
              PG  P       P  P  +  P            +P S  L               PP
Sbjct: 1255 PDPGP-PGDQGPPGPDGPRGAPGPP----------GLPGSVDLLRGEPGDCGLPGPPGPP 1303

Query: 1042 ARSPNLPSMNNMPGM-GINTQNPRISGPNPVVPMPTLSP---MGMTQPLSHSNQMPSPNA 1097
               P  P     PG  G + Q   +  P P  P     P    G+  P         P  
Sbjct: 1304 G-PPGPPGYKGFPGCDGKDGQKGPVGFPGPQGPHGFPGPPGEKGLPGPPGRKGPTGLPGP 1362

Query: 1098 VGPNIPP---------HGVPMGPGLMSHNPIMGHGSQEPPMVP--------QGRMGFPQG 1140
             G   PP          G+P  PG+      MG      P  P         GR G   G
Sbjct: 1363 RGEPGPPADVDDCPRIPGLPGAPGMRGPEGAMGLPGMRGPSGPGCKGEPGLDGRRGV-DG 1421

Query: 1141 FPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRP 1180
             P    PP +      G +G  G +PGG G P  GP+G P
Sbjct: 1422 VPGSPGPPGR-----KGDTGEDG-YPGGPGPP--GPIGDP 1453



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 93/331 (28%), Positives = 119/331 (35%), Gaps = 74/331 (22%)

Query: 1123 GSQEPPMVP--QGRMGFPQGFP-PVQSPPQQVPFPHNGPSGGQGS-----------FPGG 1168
            GS+ PP  P  QG +G P G P P+    ++      GP G  G            FPG 
Sbjct: 62   GSRGPPGPPGPQGPIG-PLGAPGPIGLSGEKGMRGDRGPPGAAGDKGDKGPTGVPGFPGL 120

Query: 1169 MGFPGE----GPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVI 1224
             G PG     GP G+P     S  + +   PG PGG                        
Sbjct: 121  DGIPGHPGPPGPRGKPG---MSGHNGSRGDPGFPGGR----------------------- 154

Query: 1225 RPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRM 1284
              GA G P   L    P EK  +    F  G V G +  +G  PG   + G  G   P  
Sbjct: 155  --GALG-PGGPLGH--PGEKGEKGNSVFILGAVKGIQGDRGD-PGLPGLPGSWGAGGPAG 208

Query: 1285 GLALPGMGG-PGPVGTPDIP-LGTAPSMPGHNPMRPPAFL-QQGMMGPHHRMMSPAQSTM 1341
                PG  G  GP G P  P L   P +     M  P  + QQG  GP   +  P     
Sbjct: 209  PTGYPGEPGLVGPPGQPGRPGLKGNPGVGVKGQMGDPGEVGQQGSPGPTLLVEPPDFCLY 268

Query: 1342 PGQPTLMSNPAAAVGMI--PGKD-------RGPAGLYTHPGPVGSPGMMMSMQGMMGPQQ 1392
             G+  +   P   VG+   PG+        +G  G+   PGP G PG   S  G  G + 
Sbjct: 269  KGEKGIKGIPGM-VGLPGPPGRKGESGIGAKGEKGIPGFPGPRGDPGSYGS-PGFPGLKG 326

Query: 1393 NIMIPPQMRPRGMAADVGMGGFSQGPGNPGN 1423
             +         G+  D G+ G     G+PGN
Sbjct: 327  EL---------GLVGDPGLFGLIGPKGDPGN 348



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 66/258 (25%), Positives = 79/258 (30%), Gaps = 57/258 (22%)

Query: 228  RNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIP 287
            R DP      PP P           R +  PP P   P  + PP P    + G   K IP
Sbjct: 1212 RGDPGSPGISPPGP-----------RGKKGPPGP---PGSSGPPGPAG--ATGRAPKDIP 1255

Query: 288  SVGSPASSTPLPPDG----TGPNSTPNNRAVTPVSQGSNS--SSADPKAPPPPPVSSGEP 341
              G P    P  PDG     GP   P +  +     G         P  PP PP   G P
Sbjct: 1256 DPGPPGDQGPPGPDGPRGAPGPPGLPGSVDLLRGEPGDCGLPGPPGPPGPPGPPGYKGFP 1315

Query: 342  PTLGEN----PDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDG 397
               G++    P G    Q  H               FP      G      ++ P  L G
Sbjct: 1316 GCDGKDGQKGPVGFPGPQGPHG--------------FPGPPGEKGLPGPPGRKGPTGLPG 1361

Query: 398  PQKKPEGPIQA-MMAQSQSLGKGPGPRTDVGA--------PFGP--------QGHRDVPF 440
            P+ +P  P       +   L   PG R   GA        P GP         G R V  
Sbjct: 1362 PRGEPGPPADVDDCPRIPGLPGAPGMRGPEGAMGLPGMRGPSGPGCKGEPGLDGRRGVDG 1421

Query: 441  SPDEMVPPSMNSQSGTIG 458
             P    PP     +G  G
Sbjct: 1422 VPGSPGPPGRKGDTGEDG 1439



 Score = 34.7 bits (78), Expect = 0.67
 Identities = 38/136 (27%), Positives = 50/136 (36%), Gaps = 34/136 (25%)

Query: 6    PKVRSSPSGNTQSSPKSKQ--EVMVRPPTVMSPSGNPQLDSKFSNQGKQG-----GSASQ 58
            P +R  P       P+  Q    +  PP +  PSG+P L+     +G++G     G    
Sbjct: 1138 PGLRGQPGEMGDPGPRGLQGDPGIPGPPGIKGPSGSPGLNGLHGLKGQKGTKGASGLHDV 1197

Query: 59   SQPSPC----------DSKSGGHTP------KALPGPGGSMGLKNGAGNGAKGKGKRERS 102
              P P           D  S G +P      K  PGP GS G    A  GA G+  +   
Sbjct: 1198 GPPGPVGIPGLKGERGDPGSPGISPPGPRGKKGPPGPPGSSGPPGPA--GATGRAPK--- 1252

Query: 103  ISADSFDQRDPGTPND 118
                  D  DPG P D
Sbjct: 1253 ------DIPDPGPPGD 1262



 Score = 32.3 bits (72), Expect = 3.3
 Identities = 33/136 (24%), Positives = 45/136 (33%), Gaps = 32/136 (23%)

Query: 12  PSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGK---QGGSASQSQPSPCDSKS 68
           P G      K  + +    P  M P G P L  +  ++G     G   ++  P P     
Sbjct: 477 PGGRGPKGEKGNEGLCACEPGPMGPPGPPGLPGRQGSKGDLGLPGWLGTKGDPGP----P 532

Query: 69  GGHTPKALPGPGGSMGLKNGAGNGAKG----------KGKR-------------ERSISA 105
           G   P  LPG  G+ G       GAKG          KG+R                   
Sbjct: 533 GAEGPPGLPGKHGASG--PPGNKGAKGDMVVSRVKGHKGERGPDGPPGFPGQPGSHGRDG 590

Query: 106 DSFDQRDPGTPNDDSD 121
            + ++ DPG P D  D
Sbjct: 591 HAGEKGDPGPPGDHED 606



 Score = 31.6 bits (70), Expect = 5.7
 Identities = 23/90 (25%), Positives = 30/90 (33%), Gaps = 7/90 (7%)

Query: 30  PPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGA 89
           PP    P G P        +GK G          C    G    K + G  G  GL+   
Sbjct: 901 PPGPKGPRGLPGFPGFPGERGKPGAEG-------CPGAKGEPGEKGMSGLPGDRGLRGAK 953

Query: 90  GNGAKGKGKRERSISADSFDQRDPGTPNDD 119
           G       + E +I +      +PG P DD
Sbjct: 954 GAIGPPGDEGEMAIISQKGTPGEPGPPGDD 983


>gi|32140760 collagen, type XXVII, alpha 1 [Homo sapiens]
          Length = 1860

 Score =  112 bits (281), Expect = 2e-24
 Identities = 351/1469 (23%), Positives = 471/1469 (32%), Gaps = 229/1469 (15%)

Query: 51   KQGGSAS--QSQPSPCDSKSGGHTPKALPGPGGSMGLKN------GAGNGAKGKGKRERS 102
            KQ G A   QS   P  S+  G  P         +GL+N        G+   G+G R   
Sbjct: 234  KQCGQADTYQSPLGPLFSQDSGR-PFTFQSDLALLGLENLTTATPALGSLPAGRGPRGTV 292

Query: 103  ISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTP---HSMTPSNATAPRSSTPSHG 159
                      P TP         N   H+       TP     ++ SNA  P       G
Sbjct: 293  A---------PATPTKPQRTSPTNPHQHMAVGGPAQTPLLPAKLSASNALDPMLPASVGG 343

Query: 160  QTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAP 219
             T    P  AQ +           +  K +            S  I  I +    + TAP
Sbjct: 344  STRTPRPAAAQPSQKITATKIPKSLPTKPSAP----------STSIVPIKSPHPTQKTAP 393

Query: 220  LNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESP 279
             +   SAL    +  P   P PA   + + +  +  P  P P P      PP     + P
Sbjct: 394  SSFTKSALPTQKQVPPTSRPVPARVSRPAEKPIQRNPGMPRPPPPSTRPLPPTTSSSKKP 453

Query: 280  -----GVENKLIPSVGSPAS---STPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAP 331
                   E K+      PAS   ST  PP  T  +S+P   A TP   GS  S+  P   
Sbjct: 454  IPTLARTEAKITSHASKPASARTSTHKPPPFTALSSSP---APTP---GSTRSTRPPATM 507

Query: 332  PPPPVSSGEP------PTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFP--DEKEFTGA 383
             PP   +  P      PT G  P G S++ +          +   R   P    K     
Sbjct: 508  VPPTSGTSTPRTAPAVPTPGSAPTG-SKKPIGSEASKKAGPKSSPRKPVPLRPGKAARDV 566

Query: 384  QSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPD 443
                    P     PQ   +     ++A +Q L   P P +   + F   G    PF P 
Sbjct: 567  PLSDLTTRPSPRQ-PQPSQQTTPALVLAPAQFLSSSPRPTSSGYSIFHLAG--STPF-PL 622

Query: 444  EMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVH 503
             M PP      G  GP  L  +     A                                
Sbjct: 623  LMGPPGPKGDCGLPGPPGLPGLPGIPGA-------------------------------- 650

Query: 504  QHGPRGV--------VRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNM 555
              GPRG         + GPP         G +PG      DG      LP  G++ +P  
Sbjct: 651  -RGPRGPPGPYGNPGLPGPPGAKGQKGDPGLSPGKAH---DGAKGDMGLP--GLSGNPGP 704

Query: 556  PGSQMR--LPGFAGMINSEME-GPN-VPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGI 611
            PG +     PG AG    + + GP   P     PG  G+  P   P     R +    G+
Sbjct: 705  PGRKGHKGYPGPAGHPGEQGQPGPEGSPGAKGYPGRQGLPGPVGDPGPKGSRGYIGLPGL 764

Query: 612  FSGPGR-GER-FPNPQGLSEEMFQQQLAEKQLGLP--PGMAMEGIRPSMEMNRMIPGSQR 667
            F  PG  GER  P   G   +M          G+P  PG+  E   P ++ N   PG   
Sbjct: 765  FGLPGSDGERGLPGVPGKRGKM----------GMPGFPGVFGERGPPGLDGN---PGELG 811

Query: 668  HMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMG----PGRELEFGM--VPSGMKGDVN 721
               PG   +   I   G L P     PKG+   MG    PG + + G   VP G+ GD  
Sbjct: 812  L--PGPPGVPGLIGDLGVLGPIGYPGPKGMKGLMGSVGEPGLKGDKGEQGVP-GVSGDPG 868

Query: 722  LNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYG--- 778
               + GS  Q +P      G  P  + K+   GS   P        P    P  + G   
Sbjct: 869  FQGDKGS--QGLPGFPGARGK-PGPLGKVGDKGSIGFPGPPGPEGFPGDIGPPGDNGPEG 925

Query: 779  MGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPP---LPLNPSSNPTSLNTAP 835
            M  +P      GP    G      P+GP       L   P     P  P  +        
Sbjct: 926  MKGKPGARGLPGPRGQLGPEGDEGPMGPPGAPG--LEGQPGRKGFPGRPGLDGVKGEPGD 983

Query: 836  PVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGM 895
            P + G   +   +   G  V  PGI   K      +  P +  P G++  P  P  +   
Sbjct: 984  PGRPGPVGEQGFMGFIGL-VGEPGIVGEKGDR-GMMGPPGVPGPKGSMGHPGMPGGMGTP 1041

Query: 896  -LAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPL 954
               GP      + PP +  A       + P  PA   G      PP   P   P      
Sbjct: 1042 GEPGPQGPPGSRGPPGMRGAKGRRGP-RGPDGPAGEQGSRGLKGPP--GPQGRPGRPGQQ 1098

Query: 955  TMASPAMLGNVESGGPP--PPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSR 1012
             +A     G++ S G P  P  +  P +  +PG           P P   Q P+      
Sbjct: 1099 GVAGER--GHLGSRGFPGIPGPSGPPGTKGLPGE----------PGPQGPQGPIG-PPGE 1145

Query: 1013 MSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPN-PV 1071
            M     P +       +   A    D  P  +P    +    G       P + G + P+
Sbjct: 1146 MGPKGPPGAVG--EPGLPGEAGMKGDLGPLGTPGEQGLIGQRG------EPGLEGDSGPM 1197

Query: 1072 VPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVP 1131
             P       G   P     +      +G + PP G P   G+       G   ++     
Sbjct: 1198 GPDGLKGDRGDPGPDGEHGEKGQEGLMGEDGPP-GPPGVTGVRGPEGKSGKQGEKGRTGA 1256

Query: 1132 QGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSF-----PGGMGFPGE------------ 1174
            +G  G+      +  P    P    GP G +GS      PG MG  GE            
Sbjct: 1257 KGAKGYQGQLGEMGVPGDPGPPGTPGPKGSRGSLGPTGAPGRMGAQGEPGLAGYDGHKGI 1316

Query: 1175 -GPLGRPSNLPQSSADAALCKPGGPGGP--DSFTVLGNSMPSVFTDPDL--QEVI----- 1224
             GPLG P    +        K  GP GP  D   V          DP    QE +     
Sbjct: 1317 VGPLGPPGPKGEKGEQGEDGKAEGPPGPPGDRGPVGDRGDRGEPGDPGYPGQEGVQGLRG 1376

Query: 1225 RPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRM 1284
            +PG  G P     R  P  K S+        E P  KQ +   PG   +QG+ G   PR 
Sbjct: 1377 KPGQQGQPGHPGPRGWPGPKGSKG------AEGPKGKQGKAGAPGRRGVQGLQGLPGPRG 1430

Query: 1285 GLALPGMGG-PGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPG 1343
             +   G+ G  GP G P    G A           P     G MGP  +  +P  + +PG
Sbjct: 1431 VVGRQGLEGIAGPDGLPGRD-GQAGQQGEQGDDGDP-----GPMGPAGKRGNPGVAGLPG 1484

Query: 1344 Q--PTLMSNPAAAVGMI--PGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQ 1399
               P      +   G +  PGK RG  G    PG  G PG     +G  G    +  P  
Sbjct: 1485 AQGPPGFKGESGLPGQLGPPGK-RGTEGRTGLPGNQGEPGS----KGQPGDSGEMGFPGM 1539

Query: 1400 ---MRPRGMAADVGMGGFSQGPGNPGNMM 1425
                 P+G   D+G  G  QGP  P  +M
Sbjct: 1540 AGLFGPKGPPGDIGFKGI-QGPRGPPGLM 1567



 Score = 32.7 bits (73), Expect = 2.6
 Identities = 27/96 (28%), Positives = 34/96 (35%), Gaps = 6/96 (6%)

Query: 33   VMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAG-- 90
            +  P G P  D +   QG+QG         P   K G      LPG  G  G K  +G  
Sbjct: 1440 IAGPDGLPGRDGQAGQQGEQGDDGDPGPMGPA-GKRGNPGVAGLPGAQGPPGFKGESGLP 1498

Query: 91   --NGAKGKGKRERSISADSFDQRDPGTPNDDSDIKE 124
               G  GK   E        +Q +PG+     D  E
Sbjct: 1499 GQLGPPGKRGTEGRTGLPG-NQGEPGSKGQPGDSGE 1533


>gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Homo
            sapiens]
          Length = 1818

 Score =  112 bits (280), Expect = 3e-24
 Identities = 264/1034 (25%), Positives = 347/1034 (33%), Gaps = 166/1034 (16%)

Query: 506  GPRGVVRGPPPPYQMTPSEG--WAPGGT----EPFSDGINMPHSLP----------PRGM 549
            GPRGV +GPP P       G   A GG     EP + G      LP           RG 
Sbjct: 574  GPRGV-QGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGP 632

Query: 550  APHPNMPGSQ-MR----------LPGFAGMINSEMEGPN-VPNPASRPGLSGVSWPDDVP 597
               P  PG   MR          LPG AG     + GP   P    +PG++GV  P   P
Sbjct: 633  QGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRG--LLGPRGTPGAPGQPGMAGVDGPPG-P 689

Query: 598  KI---PDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRP 654
            K    P G   PPGQ    GP   +  P PQG           EK     PG+A  G+ P
Sbjct: 690  KGNMGPQGEPGPPGQQGNPGP---QGLPGPQGPIGPP-----GEKGPQGKPGLA--GL-P 738

Query: 655  SMEMNRMIPGSQRHM-EPGN-NPIFPRIPV--EGPLSPSRGDFPKGIPPQMGPGRELEFG 710
              +     PG +    E G   P  P+ P+   GP      D  +G+    G   E  F 
Sbjct: 739  GADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGF- 797

Query: 711  MVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLR--PGGSDMLPAQQKMVPLP 768
                G KGD+ L  + G   Q+ P+   +   GP+        PG S     + K+    
Sbjct: 798  ---PGFKGDMGLKGDRGEVGQIGPRG-EDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPG 853

Query: 769  FGEHPQQEYGMGPRPFLPMSQGPGSNS-----------GLRNLREPIGPDQRTNSRLSHM 817
               +P ++   GP+        PG+N            G R  R P GP     +R    
Sbjct: 854  LPGYPGRQ---GPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTG 910

Query: 818  PPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQ--VHSPGINPLKSPTMHQVQSPM 875
             P P   S         PP +RG       +   G +     PG + L      + ++  
Sbjct: 911  KPGPKGTSGGDGP--PGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGF 968

Query: 876  LGSPS----GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSP 931
             G       G +  PQ P+   G + G         PP  G         K  +   P P
Sbjct: 969  QGKTGPPGPGGVVGPQGPTGETGPI-GERGHPGPPGPP--GEQGLPGAAGKEGAKGDPGP 1025

Query: 932  GWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSST 991
               S    P    G P     P    +P + G     GPP P  S        GS  ++ 
Sbjct: 1026 QGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGER----GSAGTAG 1081

Query: 992  PYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMN 1051
            P  +P  P   Q P      + +        P   D ++        + PA SP      
Sbjct: 1082 PIGLPGRPG-PQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDK 1140

Query: 1052 NM---PGMGINTQNPRISGPN--PVVPMPTLSP--------------MGMTQPLSHSNQM 1092
                 PG   +  +   +GP   P +  P  +P               GM          
Sbjct: 1141 GEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGAR 1200

Query: 1093 PSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVP 1152
              P   GP I   G+P  PG    N  +G      P  P+G  G P G    Q PP  V 
Sbjct: 1201 GFPGPPGP-IGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQG-PNGADGPQGPPGSVG 1258

Query: 1153 FPHNGPSGGQGSFPGGMGFPGE----GPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLG 1208
                    G+    G  G PGE    GP G      ++    A   PG  G P      G
Sbjct: 1259 SVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKG 1318

Query: 1209 NSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEK-----PSQTLQYFPRGEV--PGRK 1261
            N  P  F          PG  G P       +  +K     P Q     P GE   PG  
Sbjct: 1319 NPGPVGFPGD-------PGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPP 1371

Query: 1262 QPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGP-GPVGTPDIPLGTAPSMPGHNPMR--P 1318
              +GP PG +  +G  GE+  +      G  G  GPVG P  P G     PG   +R  P
Sbjct: 1372 GKRGP-PGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVG-PQGPAGK----PGPEGLRGIP 1425

Query: 1319 PAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAA--------VGMI--PGK-----DR 1363
                +QG+ G   +   P     PG P L  +P +         +G+I  PG+     DR
Sbjct: 1426 GPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDR 1485

Query: 1364 GPAGLYTHPG------------PVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGM 1411
            G  G    PG            P+G PG    + G  GP+ N        P G   D G+
Sbjct: 1486 GLPGTQGSPGAKGDGGIPGPAGPLGPPGPP-GLPGPQGPKGN---KGSTGPAGQKGDSGL 1541

Query: 1412 GGFSQGPGNPGNMM 1425
             G    PG PG ++
Sbjct: 1542 PGPPGSPGPPGEVI 1555



 Score =  107 bits (268), Expect = 6e-23
 Identities = 280/1140 (24%), Positives = 371/1140 (32%), Gaps = 189/1140 (16%)

Query: 420  PGPRTDVG--APFGPQGHRDVPFSPDEMVP---PSMNSQSGTIGPDHLDHMTPEQIAWLK 474
            PGP    G   P G QG    P  P +  P   P +    G  GP     M P +     
Sbjct: 456  PGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDG 515

Query: 475  LQQEFYEEKRRKQEQVVVQQCSL----------------------------QDMMVHQHG 506
             +       +  Q Q ++QQ  +                            +       G
Sbjct: 516  SKGPTI-SAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGESGDPGPQG 574

Query: 507  PRGVVRGPPPPYQMTPSEG--WAPGGT----EPFSDGINMPHSLP----------PRGMA 550
            PRG V+GPP P       G   A GG     EP + G      LP           RG  
Sbjct: 575  PRG-VQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQ 633

Query: 551  PHPNMPGSQ-MR----------LPGFAGMINSEMEGP-NVPNPASRPGLSGVSWPDDVPK 598
              P  PG   MR          LPG AG     + GP   P    +PG++GV  P   PK
Sbjct: 634  GPPGPPGDDGMRGEDGEIGPRGLPGEAG--PRGLLGPRGTPGAPGQPGMAGVDGPPG-PK 690

Query: 599  ---IPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPS 655
                P G   PPGQ    GP   +  P PQG           EK     PG+A  G+ P 
Sbjct: 691  GNMGPQGEPGPPGQQGNPGP---QGLPGPQGPIGPP-----GEKGPQGKPGLA--GL-PG 739

Query: 656  MEMNRMIPG--SQRHMEPGNNPIFPRIPV--EGPLSPSRGDFPKGIPPQMGPGRELEFGM 711
             +     PG   Q   +    P  P+ P+   GP      D  +G+    G   E  F  
Sbjct: 740  ADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGF-- 797

Query: 712  VPSGMKGDVNLNVNMGSNSQMIPQ-----KMREAGAGPEEMLKLRPGGSDMLPAQQKMVP 766
               G KGD+ L  + G   Q+ P+     +  +  AGP       PG S     + K+  
Sbjct: 798  --PGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTG----DPGPSGQAGEKGKLGV 851

Query: 767  LPFGEHPQQEYGMGPRPFLPMSQGPGSNS-----------GLRNLREPIGPDQRTNSRLS 815
                 +P ++   GP+        PG+N            G R  R P GP     +R  
Sbjct: 852  PGLPGYPGRQ---GPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGP 908

Query: 816  HMPPLPLNPSSNPTSLNTAPPVQRGL--GRKPLDISVAGSQVHSPGINPLKSPTMHQVQS 873
               P P   S         PP +RG    + P+           PG + L      + ++
Sbjct: 909  TGKPGPKGTSGGDGP--PGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGET 966

Query: 874  PMLGSPS----GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAP 929
               G       G +  PQ P+   G + G         PP  G         K  +   P
Sbjct: 967  GFQGKTGPPGPGGVVGPQGPTGETGPI-GERGHPGPPGPP--GEQGLPGAAGKEGAKGDP 1023

Query: 930  SPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPS 989
             P   S    P    G P     P    +P + G     GPP P  S        GS  +
Sbjct: 1024 GPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGER----GSAGT 1079

Query: 990  STPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPS 1049
            + P  +P  P   Q P      + +        P   D ++        + PA SP    
Sbjct: 1080 AGPIGLPGRPG-PQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDG 1138

Query: 1050 MN---NMPGMGINTQNPRISGP--NPVVPMPTLSP--------------MGMTQPLSHSN 1090
                   PG   +  +   +GP   P +  P  +P               GM        
Sbjct: 1139 DKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEG 1198

Query: 1091 QMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQ 1150
                P   GP I   G+P  PG    N  +G      P  P+G  G P G    Q PP  
Sbjct: 1199 ARGFPGPPGP-IGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQG-PNGADGPQGPPGS 1256

Query: 1151 VPFPHNGPSGGQGSFPGGMGFPGE----GPLGRPSNLPQSSADAALCKPGGPGGPDSFTV 1206
            V         G+    G  G PGE    GP G      ++    A   PG  G P     
Sbjct: 1257 VGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGP 1316

Query: 1207 LGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEK-----PSQTLQYFPRGEV--PG 1259
             GN  P  F          PG  G P       +  +K     P Q     P GE   PG
Sbjct: 1317 KGNPGPVGFPGD-------PGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPG 1369

Query: 1260 RKQPQGPGPGFSHMQGMMGEQAPRMGLALPG-MGGPGPVGTPDIPLGTAPSMPGHNPMR- 1317
                +GP PG +  +G  GE+  +      G  G  GPVG P  P G     PG   +R 
Sbjct: 1370 PPGKRGP-PGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVG-PQGPAG----KPGPEGLRG 1423

Query: 1318 -PPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAA--------AVGMI-PGKDRGPAG 1367
             P    +QG+ G   +   P     PG P L  +P +         +G+I P  ++G  G
Sbjct: 1424 IPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKG 1483

Query: 1368 LYTHPGPVGSPGM-----MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
                PG  GSPG      +    G +GP     +P    P+G     G  G     G PG
Sbjct: 1484 DRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPG 1543



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 268/1077 (24%), Positives = 351/1077 (32%), Gaps = 186/1077 (17%)

Query: 454  SGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQ----DMMV------- 502
            SGT  P+ ++ +  E+     L  E Y+ +R+  E  + +   +     D++V       
Sbjct: 338  SGTNEPNPVEEIFTEEY----LTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGDLGEY 393

Query: 503  --HQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQM 560
              +++         PP  +  P     P  T+     IN   +   +G    P +    M
Sbjct: 394  DFYEYKEYEDKPTSPPNEEFGPG---VPAETDITETSINGHGAYGEKGQKGEPAVVEPGM 450

Query: 561  RLPGFAGMINSE--MEGPNVPNPASRPGLSGVSWPDDVPKIP--DGRNFPPGQGI---FS 613
             + G  G       M  P +  P   PG  G   P   P +P  DG   PPG  +   F 
Sbjct: 451  LVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFR 510

Query: 614  GPGRGERFPNPQGLSEEMFQQQLAEKQLGL--PPG-MAMEGIRPSMEMNRMIPGSQRHM- 669
              G G + P      E   Q  L + ++ L  PPG M + G RP         G++    
Sbjct: 511  YGGDGSKGPTISA-QEAQAQAILQQARIALRGPPGPMGLTG-RPGPVGGPGSSGAKGESG 568

Query: 670  EPGNNPIFPRIPVEGPLSPS-----RG----DFPKGIPPQMGPGRELEFGMVPSGMKGDV 720
            +PG  P  PR  V+GP  P+     RG    D  +G+P + G   +  F  +P G+ GD 
Sbjct: 569  DPG--PQGPR-GVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLP-GLPGDK 624

Query: 721  NLNVNMGSNSQMIP---QKMR----EAG-------AGPEEMLKLRPGGSDMLPAQQKMVP 766
                  G      P     MR    E G       AGP  +L   P G+   P Q  M  
Sbjct: 625  GHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLG--PRGTPGAPGQPGMAG 682

Query: 767  LPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSR----LSHMPPL-- 820
            +     P+   G    P  P  QG     GL   + PIGP      +    L+ +P    
Sbjct: 683  VDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADG 742

Query: 821  -PLNPSSNPTSLN---TAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPML 876
             P +P     S       PP  +G    P    V G+     G+  LK     + +    
Sbjct: 743  PPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGAD----GVRGLKGSKGEKGEDGFP 798

Query: 877  GSPSG-NLKSPQTPSQLAGMLA-----GPAAAASIKSPPVLGSAAASPVHLKSPSLPAPS 930
            G      LK  +      G        GP   A     P     A     L  P LP   
Sbjct: 799  GFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPG-Y 857

Query: 931  PGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSS 990
            PG    PK     PG P  +            G     GP  P  S+ A        P  
Sbjct: 858  PG-RQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKG 916

Query: 991  TP-YTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARS--PNL 1047
            T     PP P   + P          F  P   P                PP +   P  
Sbjct: 917  TSGGDGPPGPPGERGPQG--PQGPVGFPGPKGPP---------------GPPGKDGLPGH 959

Query: 1048 PSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGV 1107
            P      G    T  P   GP  VV      P G T P+        P   G      G+
Sbjct: 960  PGQRGETGFQGKTGPP---GPGGVV--GPQGPTGETGPIGERGHPGPPGPPG----EQGL 1010

Query: 1108 PMGPGLMSHNPIMGHGSQEPPMVPQGRMGFP--QGFPPVQSPPQQVPFPHNGPSGGQG-- 1163
            P   G        G         P G  GFP  +G P  Q  P        G  GG+G  
Sbjct: 1011 PGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAP--------GLKGGEGPQ 1062

Query: 1164 SFPGGMGFPGE-------GPLGRPSNL-PQSSADAALCK-------PGGPGGPDSFT--- 1205
              PG +G PGE       GP+G P    PQ     A  K       P GP G D      
Sbjct: 1063 GPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPV 1122

Query: 1206 -VLGNSMP--SVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQ 1262
             + G + P  S   D D  E+  PG  G  + D     P   P        +G V     
Sbjct: 1123 GLPGPAGPAGSPGEDGDKGEIGEPGQKG-SKGDKGENGPPGPPGL------QGPVGAPGI 1175

Query: 1263 PQGPG-PGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHN----PMR 1317
              G G PG    QGM G++        P  G PGP+G   +P    P   G N    PM 
Sbjct: 1176 AGGDGEPGPRGQQGMFGQKGDEGARGFP--GPPGPIGLQGLP--GPPGEKGENGDVGPMG 1231

Query: 1318 PPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPG-KDRGPAGLYTHPGPVG 1376
            PP     G  GP      P  +  P        P  +VG + G  ++G  G   +PGP G
Sbjct: 1232 PPG--PPGPRGP----QGPNGADGP------QGPPGSVGSVGGVGEKGEPGEAGNPGPPG 1279

Query: 1377 SPGM-----------MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
              G+                G  GP      P    P+G    VG  G    PG PG
Sbjct: 1280 EAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPG 1336



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 183/717 (25%), Positives = 234/717 (32%), Gaps = 121/717 (16%)

Query: 261  PAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQG 320
            P P  K   P  P  R   G + K     G P     + P G    + P      P    
Sbjct: 948  PGPPGKDGLPGHPGQRGETGFQGK----TGPPGPGGVVGPQGPTGETGPIGERGHP---- 999

Query: 321  SNSSSADPKAPPPPPVSSGEPPTLGEN-------PDGLSQEQLEHRERSLQTLRDIQRML 373
                      PP PP   G P   G+        P G+S +      R            
Sbjct: 1000 ---------GPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRG----------- 1039

Query: 374  FPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQ 433
            FP E+   GAQ G P    G  +GPQ  P GP+ +   +  +   GP        P GP 
Sbjct: 1040 FPGERGLPGAQ-GAPGLKGG--EGPQGPP-GPVGSPGERGSAGTAGPIGLPGRPGPQGPP 1095

Query: 434  GHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQ 493
            G      +P E  P     + G  GP  L    P   A         E+  + +     Q
Sbjct: 1096 GPAGEKGAPGEKGPQGPAGRDGVQGPVGLP--GPAGPAGSP-----GEDGDKGEIGEPGQ 1148

Query: 494  QCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDG-INMPHSLPPRGMAPH 552
            + S  D    ++GP     GPP       + G A G  EP   G   M       G    
Sbjct: 1149 KGSKGDK--GENGP----PGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGF 1202

Query: 553  PNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIF 612
            P  PG  + L G  G    + E  +V  P   PG  G   P   P   DG   PPG  + 
Sbjct: 1203 PGPPG-PIGLQGLPGPPGEKGENGDV-GPMGPPGPPGPRGPQG-PNGADGPQGPPG-SVG 1258

Query: 613  SGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPG 672
            S  G GE+              +  E     PPG A  G           P  +R  +  
Sbjct: 1259 SVGGVGEK-------------GEPGEAGNPGPPGEAGVG----------GPKGERGEKGE 1295

Query: 673  NNPIFPRIPVEGPLSPSRGDFPKGIPPQMG----PGRELEFGMV-PSGMKGDVNLNVNMG 727
              P     P  G   P   D PKG P  +G    PG   E G     G+ GD   + + G
Sbjct: 1296 AGPPGAAGP-PGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPG 1354

Query: 728  SNSQMIPQKMREAGAGPEEMLKLRPG--GSDMLPAQQKMVPLPFGEHPQQEYG-MGPRPF 784
                  P    EAG       +  PG  G++    ++        E P  + G +GP   
Sbjct: 1355 QPGP--PGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGP--- 1409

Query: 785  LPMSQGPGSN---SGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGL 841
                QGP       GLR +  P+G      +     PP P+ P   P           GL
Sbjct: 1410 ----QGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLP-----------GL 1454

Query: 842  GRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAA 901
               P      G + H PG+  L  P   Q +    G P G   SP       G + GPA 
Sbjct: 1455 KGDP---GSKGEKGH-PGLIGLIGPPGEQGEKGDRGLP-GTQGSPGAKGD--GGIPGPAG 1507

Query: 902  AASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMAS 958
                  PP L      P   K  + PA   G +  P PP  SPG P     PL + S
Sbjct: 1508 PLGPPGPPGL-PGPQGPKGNKGSTGPAGQKGDSGLPGPP-GSPGPPGEVIQPLPILS 1562



 Score = 35.0 bits (79), Expect = 0.52
 Identities = 97/409 (23%), Positives = 128/409 (31%), Gaps = 87/409 (21%)

Query: 231  PKPLPQQ--PPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKL--I 286
            P P+  Q  P  P  + +N        P PP P     P     P  +  PG    +  +
Sbjct: 1206 PGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGP--QGPPGSVGSVGGV 1263

Query: 287  PSVGSPASS-TPLPPDGTGPNSTPNNR----------AVTPVSQGSNSSSADPKAPPPPP 335
               G P  +  P PP   G       R          A  P           PK  P P 
Sbjct: 1264 GEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPV 1323

Query: 336  VSSGEPPTLGE----NPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQS-GGPQQ 390
               G+P   GE      DG+  ++ E  +              P +    G     GP  
Sbjct: 1324 GFPGDPGPPGEPGPAGQDGVGGDKGEDGD--------------PGQPGPPGPSGEAGPPG 1369

Query: 391  NPGVLDGPQKK-PEGPIQAMMAQSQSLGKGP-------GPRTDVGAPFGPQGHRDVPFSP 442
             PG    P     EG      A+ ++  +GP       GP+   G P GP+G R +P   
Sbjct: 1370 PPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKP-GPEGLRGIPGPV 1428

Query: 443  DEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMV 502
             E   P    Q G  GP     M P  +  LK       EK       ++     Q    
Sbjct: 1429 GEQGLPGAAGQDGPPGP-----MGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQG--- 1480

Query: 503  HQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRL 562
             + G RG+           P    +PG      DG  +P    P G    P +PG Q   
Sbjct: 1481 -EKGDRGL-----------PGTQGSPGAK---GDG-GIPGPAGPLGPPGPPGLPGPQ--- 1521

Query: 563  PGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGI 611
             G  G   S         PA + G SG+  P   P        PPG+ I
Sbjct: 1522 -GPKGNKGS-------TGPAGQKGDSGLPGPPGSPG-------PPGEVI 1555


>gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Homo
            sapiens]
          Length = 1767

 Score =  112 bits (280), Expect = 3e-24
 Identities = 264/1034 (25%), Positives = 347/1034 (33%), Gaps = 166/1034 (16%)

Query: 506  GPRGVVRGPPPPYQMTPSEG--WAPGGT----EPFSDGINMPHSLP----------PRGM 549
            GPRGV +GPP P       G   A GG     EP + G      LP           RG 
Sbjct: 523  GPRGV-QGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGP 581

Query: 550  APHPNMPGSQ-MR----------LPGFAGMINSEMEGPN-VPNPASRPGLSGVSWPDDVP 597
               P  PG   MR          LPG AG     + GP   P    +PG++GV  P   P
Sbjct: 582  QGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRG--LLGPRGTPGAPGQPGMAGVDGPPG-P 638

Query: 598  KI---PDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRP 654
            K    P G   PPGQ    GP   +  P PQG           EK     PG+A  G+ P
Sbjct: 639  KGNMGPQGEPGPPGQQGNPGP---QGLPGPQGPIGPP-----GEKGPQGKPGLA--GL-P 687

Query: 655  SMEMNRMIPGSQRHM-EPGN-NPIFPRIPV--EGPLSPSRGDFPKGIPPQMGPGRELEFG 710
              +     PG +    E G   P  P+ P+   GP      D  +G+    G   E  F 
Sbjct: 688  GADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGF- 746

Query: 711  MVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLR--PGGSDMLPAQQKMVPLP 768
                G KGD+ L  + G   Q+ P+   +   GP+        PG S     + K+    
Sbjct: 747  ---PGFKGDMGLKGDRGEVGQIGPRG-EDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPG 802

Query: 769  FGEHPQQEYGMGPRPFLPMSQGPGSNS-----------GLRNLREPIGPDQRTNSRLSHM 817
               +P ++   GP+        PG+N            G R  R P GP     +R    
Sbjct: 803  LPGYPGRQ---GPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTG 859

Query: 818  PPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQ--VHSPGINPLKSPTMHQVQSPM 875
             P P   S         PP +RG       +   G +     PG + L      + ++  
Sbjct: 860  KPGPKGTSGGDGP--PGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGF 917

Query: 876  LGSPS----GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSP 931
             G       G +  PQ P+   G + G         PP  G         K  +   P P
Sbjct: 918  QGKTGPPGPGGVVGPQGPTGETGPI-GERGHPGPPGPP--GEQGLPGAAGKEGAKGDPGP 974

Query: 932  GWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSST 991
               S    P    G P     P    +P + G     GPP P  S        GS  ++ 
Sbjct: 975  QGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGER----GSAGTAG 1030

Query: 992  PYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMN 1051
            P  +P  P   Q P      + +        P   D ++        + PA SP      
Sbjct: 1031 PIGLPGRPG-PQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDK 1089

Query: 1052 NM---PGMGINTQNPRISGPN--PVVPMPTLSP--------------MGMTQPLSHSNQM 1092
                 PG   +  +   +GP   P +  P  +P               GM          
Sbjct: 1090 GEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGAR 1149

Query: 1093 PSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVP 1152
              P   GP I   G+P  PG    N  +G      P  P+G  G P G    Q PP  V 
Sbjct: 1150 GFPGPPGP-IGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQG-PNGADGPQGPPGSVG 1207

Query: 1153 FPHNGPSGGQGSFPGGMGFPGE----GPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLG 1208
                    G+    G  G PGE    GP G      ++    A   PG  G P      G
Sbjct: 1208 SVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKG 1267

Query: 1209 NSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEK-----PSQTLQYFPRGEV--PGRK 1261
            N  P  F          PG  G P       +  +K     P Q     P GE   PG  
Sbjct: 1268 NPGPVGFPGD-------PGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPP 1320

Query: 1262 QPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGP-GPVGTPDIPLGTAPSMPGHNPMR--P 1318
              +GP PG +  +G  GE+  +      G  G  GPVG P  P G     PG   +R  P
Sbjct: 1321 GKRGP-PGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVG-PQGPAGK----PGPEGLRGIP 1374

Query: 1319 PAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAA--------VGMI--PGK-----DR 1363
                +QG+ G   +   P     PG P L  +P +         +G+I  PG+     DR
Sbjct: 1375 GPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDR 1434

Query: 1364 GPAGLYTHPG------------PVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGM 1411
            G  G    PG            P+G PG    + G  GP+ N        P G   D G+
Sbjct: 1435 GLPGTQGSPGAKGDGGIPGPAGPLGPPGPP-GLPGPQGPKGN---KGSTGPAGQKGDSGL 1490

Query: 1412 GGFSQGPGNPGNMM 1425
             G    PG PG ++
Sbjct: 1491 PGPPGSPGPPGEVI 1504



 Score =  107 bits (268), Expect = 6e-23
 Identities = 280/1140 (24%), Positives = 371/1140 (32%), Gaps = 189/1140 (16%)

Query: 420  PGPRTDVG--APFGPQGHRDVPFSPDEMVP---PSMNSQSGTIGPDHLDHMTPEQIAWLK 474
            PGP    G   P G QG    P  P +  P   P +    G  GP     M P +     
Sbjct: 405  PGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDG 464

Query: 475  LQQEFYEEKRRKQEQVVVQQCSL----------------------------QDMMVHQHG 506
             +       +  Q Q ++QQ  +                            +       G
Sbjct: 465  SKGPTI-SAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGESGDPGPQG 523

Query: 507  PRGVVRGPPPPYQMTPSEG--WAPGGT----EPFSDGINMPHSLP----------PRGMA 550
            PRG V+GPP P       G   A GG     EP + G      LP           RG  
Sbjct: 524  PRG-VQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQ 582

Query: 551  PHPNMPGSQ-MR----------LPGFAGMINSEMEGP-NVPNPASRPGLSGVSWPDDVPK 598
              P  PG   MR          LPG AG     + GP   P    +PG++GV  P   PK
Sbjct: 583  GPPGPPGDDGMRGEDGEIGPRGLPGEAG--PRGLLGPRGTPGAPGQPGMAGVDGPPG-PK 639

Query: 599  ---IPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPS 655
                P G   PPGQ    GP   +  P PQG           EK     PG+A  G+ P 
Sbjct: 640  GNMGPQGEPGPPGQQGNPGP---QGLPGPQGPIGPP-----GEKGPQGKPGLA--GL-PG 688

Query: 656  MEMNRMIPG--SQRHMEPGNNPIFPRIPV--EGPLSPSRGDFPKGIPPQMGPGRELEFGM 711
             +     PG   Q   +    P  P+ P+   GP      D  +G+    G   E  F  
Sbjct: 689  ADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGF-- 746

Query: 712  VPSGMKGDVNLNVNMGSNSQMIPQ-----KMREAGAGPEEMLKLRPGGSDMLPAQQKMVP 766
               G KGD+ L  + G   Q+ P+     +  +  AGP       PG S     + K+  
Sbjct: 747  --PGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTG----DPGPSGQAGEKGKLGV 800

Query: 767  LPFGEHPQQEYGMGPRPFLPMSQGPGSNS-----------GLRNLREPIGPDQRTNSRLS 815
                 +P ++   GP+        PG+N            G R  R P GP     +R  
Sbjct: 801  PGLPGYPGRQ---GPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGP 857

Query: 816  HMPPLPLNPSSNPTSLNTAPPVQRGL--GRKPLDISVAGSQVHSPGINPLKSPTMHQVQS 873
               P P   S         PP +RG    + P+           PG + L      + ++
Sbjct: 858  TGKPGPKGTSGGDGP--PGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGET 915

Query: 874  PMLGSPS----GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAP 929
               G       G +  PQ P+   G + G         PP  G         K  +   P
Sbjct: 916  GFQGKTGPPGPGGVVGPQGPTGETGPI-GERGHPGPPGPP--GEQGLPGAAGKEGAKGDP 972

Query: 930  SPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPS 989
             P   S    P    G P     P    +P + G     GPP P  S        GS  +
Sbjct: 973  GPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGER----GSAGT 1028

Query: 990  STPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPS 1049
            + P  +P  P   Q P      + +        P   D ++        + PA SP    
Sbjct: 1029 AGPIGLPGRPG-PQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDG 1087

Query: 1050 MN---NMPGMGINTQNPRISGP--NPVVPMPTLSP--------------MGMTQPLSHSN 1090
                   PG   +  +   +GP   P +  P  +P               GM        
Sbjct: 1088 DKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEG 1147

Query: 1091 QMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQ 1150
                P   GP I   G+P  PG    N  +G      P  P+G  G P G    Q PP  
Sbjct: 1148 ARGFPGPPGP-IGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQG-PNGADGPQGPPGS 1205

Query: 1151 VPFPHNGPSGGQGSFPGGMGFPGE----GPLGRPSNLPQSSADAALCKPGGPGGPDSFTV 1206
            V         G+    G  G PGE    GP G      ++    A   PG  G P     
Sbjct: 1206 VGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGP 1265

Query: 1207 LGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEK-----PSQTLQYFPRGEV--PG 1259
             GN  P  F          PG  G P       +  +K     P Q     P GE   PG
Sbjct: 1266 KGNPGPVGFPGD-------PGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPG 1318

Query: 1260 RKQPQGPGPGFSHMQGMMGEQAPRMGLALPG-MGGPGPVGTPDIPLGTAPSMPGHNPMR- 1317
                +GP PG +  +G  GE+  +      G  G  GPVG P  P G     PG   +R 
Sbjct: 1319 PPGKRGP-PGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVG-PQGPAG----KPGPEGLRG 1372

Query: 1318 -PPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAA--------AVGMI-PGKDRGPAG 1367
             P    +QG+ G   +   P     PG P L  +P +         +G+I P  ++G  G
Sbjct: 1373 IPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKG 1432

Query: 1368 LYTHPGPVGSPGM-----MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
                PG  GSPG      +    G +GP     +P    P+G     G  G     G PG
Sbjct: 1433 DRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPG 1492



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 268/1077 (24%), Positives = 351/1077 (32%), Gaps = 186/1077 (17%)

Query: 454  SGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQ----DMMV------- 502
            SGT  P+ ++ +  E+     L  E Y+ +R+  E  + +   +     D++V       
Sbjct: 287  SGTNEPNPVEEIFTEEY----LTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGDLGEY 342

Query: 503  --HQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQM 560
              +++         PP  +  P     P  T+     IN   +   +G    P +    M
Sbjct: 343  DFYEYKEYEDKPTSPPNEEFGPG---VPAETDITETSINGHGAYGEKGQKGEPAVVEPGM 399

Query: 561  RLPGFAGMINSE--MEGPNVPNPASRPGLSGVSWPDDVPKIP--DGRNFPPGQGI---FS 613
             + G  G       M  P +  P   PG  G   P   P +P  DG   PPG  +   F 
Sbjct: 400  LVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFR 459

Query: 614  GPGRGERFPNPQGLSEEMFQQQLAEKQLGL--PPG-MAMEGIRPSMEMNRMIPGSQRHM- 669
              G G + P      E   Q  L + ++ L  PPG M + G RP         G++    
Sbjct: 460  YGGDGSKGPTISA-QEAQAQAILQQARIALRGPPGPMGLTG-RPGPVGGPGSSGAKGESG 517

Query: 670  EPGNNPIFPRIPVEGPLSPS-----RG----DFPKGIPPQMGPGRELEFGMVPSGMKGDV 720
            +PG  P  PR  V+GP  P+     RG    D  +G+P + G   +  F  +P G+ GD 
Sbjct: 518  DPG--PQGPR-GVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLP-GLPGDK 573

Query: 721  NLNVNMGSNSQMIP---QKMR----EAG-------AGPEEMLKLRPGGSDMLPAQQKMVP 766
                  G      P     MR    E G       AGP  +L   P G+   P Q  M  
Sbjct: 574  GHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLG--PRGTPGAPGQPGMAG 631

Query: 767  LPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSR----LSHMPPL-- 820
            +     P+   G    P  P  QG     GL   + PIGP      +    L+ +P    
Sbjct: 632  VDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADG 691

Query: 821  -PLNPSSNPTSLN---TAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPML 876
             P +P     S       PP  +G    P    V G+     G+  LK     + +    
Sbjct: 692  PPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGAD----GVRGLKGSKGEKGEDGFP 747

Query: 877  GSPSG-NLKSPQTPSQLAGMLA-----GPAAAASIKSPPVLGSAAASPVHLKSPSLPAPS 930
            G      LK  +      G        GP   A     P     A     L  P LP   
Sbjct: 748  GFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPG-Y 806

Query: 931  PGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSS 990
            PG    PK     PG P  +            G     GP  P  S+ A        P  
Sbjct: 807  PG-RQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKG 865

Query: 991  TP-YTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARS--PNL 1047
            T     PP P   + P          F  P   P                PP +   P  
Sbjct: 866  TSGGDGPPGPPGERGPQG--PQGPVGFPGPKGPP---------------GPPGKDGLPGH 908

Query: 1048 PSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGV 1107
            P      G    T  P   GP  VV      P G T P+        P   G      G+
Sbjct: 909  PGQRGETGFQGKTGPP---GPGGVV--GPQGPTGETGPIGERGHPGPPGPPG----EQGL 959

Query: 1108 PMGPGLMSHNPIMGHGSQEPPMVPQGRMGFP--QGFPPVQSPPQQVPFPHNGPSGGQG-- 1163
            P   G        G         P G  GFP  +G P  Q  P        G  GG+G  
Sbjct: 960  PGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAP--------GLKGGEGPQ 1011

Query: 1164 SFPGGMGFPGE-------GPLGRPSNL-PQSSADAALCK-------PGGPGGPDSFT--- 1205
              PG +G PGE       GP+G P    PQ     A  K       P GP G D      
Sbjct: 1012 GPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPV 1071

Query: 1206 -VLGNSMP--SVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQ 1262
             + G + P  S   D D  E+  PG  G  + D     P   P        +G V     
Sbjct: 1072 GLPGPAGPAGSPGEDGDKGEIGEPGQKG-SKGDKGENGPPGPPGL------QGPVGAPGI 1124

Query: 1263 PQGPG-PGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHN----PMR 1317
              G G PG    QGM G++        P  G PGP+G   +P    P   G N    PM 
Sbjct: 1125 AGGDGEPGPRGQQGMFGQKGDEGARGFP--GPPGPIGLQGLP--GPPGEKGENGDVGPMG 1180

Query: 1318 PPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPG-KDRGPAGLYTHPGPVG 1376
            PP     G  GP      P  +  P        P  +VG + G  ++G  G   +PGP G
Sbjct: 1181 PPG--PPGPRGP----QGPNGADGP------QGPPGSVGSVGGVGEKGEPGEAGNPGPPG 1228

Query: 1377 SPGM-----------MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
              G+                G  GP      P    P+G    VG  G    PG PG
Sbjct: 1229 EAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPG 1285



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 183/717 (25%), Positives = 234/717 (32%), Gaps = 121/717 (16%)

Query: 261  PAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQG 320
            P P  K   P  P  R   G + K     G P     + P G    + P      P    
Sbjct: 897  PGPPGKDGLPGHPGQRGETGFQGK----TGPPGPGGVVGPQGPTGETGPIGERGHP---- 948

Query: 321  SNSSSADPKAPPPPPVSSGEPPTLGEN-------PDGLSQEQLEHRERSLQTLRDIQRML 373
                      PP PP   G P   G+        P G+S +      R            
Sbjct: 949  ---------GPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRG----------- 988

Query: 374  FPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQ 433
            FP E+   GAQ G P    G  +GPQ  P GP+ +   +  +   GP        P GP 
Sbjct: 989  FPGERGLPGAQ-GAPGLKGG--EGPQGPP-GPVGSPGERGSAGTAGPIGLPGRPGPQGPP 1044

Query: 434  GHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQ 493
            G      +P E  P     + G  GP  L    P   A         E+  + +     Q
Sbjct: 1045 GPAGEKGAPGEKGPQGPAGRDGVQGPVGLP--GPAGPAGSP-----GEDGDKGEIGEPGQ 1097

Query: 494  QCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDG-INMPHSLPPRGMAPH 552
            + S  D    ++GP     GPP       + G A G  EP   G   M       G    
Sbjct: 1098 KGSKGDK--GENGP----PGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGF 1151

Query: 553  PNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIF 612
            P  PG  + L G  G    + E  +V  P   PG  G   P   P   DG   PPG  + 
Sbjct: 1152 PGPPG-PIGLQGLPGPPGEKGENGDV-GPMGPPGPPGPRGPQG-PNGADGPQGPPG-SVG 1207

Query: 613  SGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPG 672
            S  G GE+              +  E     PPG A  G           P  +R  +  
Sbjct: 1208 SVGGVGEK-------------GEPGEAGNPGPPGEAGVG----------GPKGERGEKGE 1244

Query: 673  NNPIFPRIPVEGPLSPSRGDFPKGIPPQMG----PGRELEFGMV-PSGMKGDVNLNVNMG 727
              P     P  G   P   D PKG P  +G    PG   E G     G+ GD   + + G
Sbjct: 1245 AGPPGAAGP-PGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPG 1303

Query: 728  SNSQMIPQKMREAGAGPEEMLKLRPG--GSDMLPAQQKMVPLPFGEHPQQEYG-MGPRPF 784
                  P    EAG       +  PG  G++    ++        E P  + G +GP   
Sbjct: 1304 QPGP--PGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGP--- 1358

Query: 785  LPMSQGPGSN---SGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGL 841
                QGP       GLR +  P+G      +     PP P+ P   P           GL
Sbjct: 1359 ----QGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLP-----------GL 1403

Query: 842  GRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAA 901
               P      G + H PG+  L  P   Q +    G P G   SP       G + GPA 
Sbjct: 1404 KGDP---GSKGEKGH-PGLIGLIGPPGEQGEKGDRGLP-GTQGSPGAKGD--GGIPGPAG 1456

Query: 902  AASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMAS 958
                  PP L      P   K  + PA   G +  P PP  SPG P     PL + S
Sbjct: 1457 PLGPPGPPGL-PGPQGPKGNKGSTGPAGQKGDSGLPGPP-GSPGPPGEVIQPLPILS 1511



 Score = 35.0 bits (79), Expect = 0.52
 Identities = 97/409 (23%), Positives = 128/409 (31%), Gaps = 87/409 (21%)

Query: 231  PKPLPQQ--PPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKL--I 286
            P P+  Q  P  P  + +N        P PP P     P     P  +  PG    +  +
Sbjct: 1155 PGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGP--QGPPGSVGSVGGV 1212

Query: 287  PSVGSPASS-TPLPPDGTGPNSTPNNR----------AVTPVSQGSNSSSADPKAPPPPP 335
               G P  +  P PP   G       R          A  P           PK  P P 
Sbjct: 1213 GEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPV 1272

Query: 336  VSSGEPPTLGE----NPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQS-GGPQQ 390
               G+P   GE      DG+  ++ E  +              P +    G     GP  
Sbjct: 1273 GFPGDPGPPGEPGPAGQDGVGGDKGEDGD--------------PGQPGPPGPSGEAGPPG 1318

Query: 391  NPGVLDGPQKK-PEGPIQAMMAQSQSLGKGP-------GPRTDVGAPFGPQGHRDVPFSP 442
             PG    P     EG      A+ ++  +GP       GP+   G P GP+G R +P   
Sbjct: 1319 PPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKP-GPEGLRGIPGPV 1377

Query: 443  DEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMV 502
             E   P    Q G  GP     M P  +  LK       EK       ++     Q    
Sbjct: 1378 GEQGLPGAAGQDGPPGP-----MGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQG--- 1429

Query: 503  HQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRL 562
             + G RG+           P    +PG      DG  +P    P G    P +PG Q   
Sbjct: 1430 -EKGDRGL-----------PGTQGSPGAK---GDG-GIPGPAGPLGPPGPPGLPGPQ--- 1470

Query: 563  PGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGI 611
             G  G   S         PA + G SG+  P   P        PPG+ I
Sbjct: 1471 -GPKGNKGS-------TGPAGQKGDSGLPGPPGSPG-------PPGEVI 1504


>gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Homo
            sapiens]
          Length = 1806

 Score =  112 bits (280), Expect = 3e-24
 Identities = 264/1034 (25%), Positives = 347/1034 (33%), Gaps = 166/1034 (16%)

Query: 506  GPRGVVRGPPPPYQMTPSEG--WAPGGT----EPFSDGINMPHSLP----------PRGM 549
            GPRGV +GPP P       G   A GG     EP + G      LP           RG 
Sbjct: 562  GPRGV-QGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGP 620

Query: 550  APHPNMPGSQ-MR----------LPGFAGMINSEMEGPN-VPNPASRPGLSGVSWPDDVP 597
               P  PG   MR          LPG AG     + GP   P    +PG++GV  P   P
Sbjct: 621  QGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRG--LLGPRGTPGAPGQPGMAGVDGPPG-P 677

Query: 598  KI---PDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRP 654
            K    P G   PPGQ    GP   +  P PQG           EK     PG+A  G+ P
Sbjct: 678  KGNMGPQGEPGPPGQQGNPGP---QGLPGPQGPIGPP-----GEKGPQGKPGLA--GL-P 726

Query: 655  SMEMNRMIPGSQRHM-EPGN-NPIFPRIPV--EGPLSPSRGDFPKGIPPQMGPGRELEFG 710
              +     PG +    E G   P  P+ P+   GP      D  +G+    G   E  F 
Sbjct: 727  GADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGF- 785

Query: 711  MVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLR--PGGSDMLPAQQKMVPLP 768
                G KGD+ L  + G   Q+ P+   +   GP+        PG S     + K+    
Sbjct: 786  ---PGFKGDMGLKGDRGEVGQIGPRG-EDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPG 841

Query: 769  FGEHPQQEYGMGPRPFLPMSQGPGSNS-----------GLRNLREPIGPDQRTNSRLSHM 817
               +P ++   GP+        PG+N            G R  R P GP     +R    
Sbjct: 842  LPGYPGRQ---GPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTG 898

Query: 818  PPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQ--VHSPGINPLKSPTMHQVQSPM 875
             P P   S         PP +RG       +   G +     PG + L      + ++  
Sbjct: 899  KPGPKGTSGGDGP--PGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGF 956

Query: 876  LGSPS----GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSP 931
             G       G +  PQ P+   G + G         PP  G         K  +   P P
Sbjct: 957  QGKTGPPGPGGVVGPQGPTGETGPI-GERGHPGPPGPP--GEQGLPGAAGKEGAKGDPGP 1013

Query: 932  GWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSST 991
               S    P    G P     P    +P + G     GPP P  S        GS  ++ 
Sbjct: 1014 QGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGER----GSAGTAG 1069

Query: 992  PYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMN 1051
            P  +P  P   Q P      + +        P   D ++        + PA SP      
Sbjct: 1070 PIGLPGRPG-PQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDK 1128

Query: 1052 NM---PGMGINTQNPRISGPN--PVVPMPTLSP--------------MGMTQPLSHSNQM 1092
                 PG   +  +   +GP   P +  P  +P               GM          
Sbjct: 1129 GEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGAR 1188

Query: 1093 PSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVP 1152
              P   GP I   G+P  PG    N  +G      P  P+G  G P G    Q PP  V 
Sbjct: 1189 GFPGPPGP-IGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQG-PNGADGPQGPPGSVG 1246

Query: 1153 FPHNGPSGGQGSFPGGMGFPGE----GPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLG 1208
                    G+    G  G PGE    GP G      ++    A   PG  G P      G
Sbjct: 1247 SVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKG 1306

Query: 1209 NSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEK-----PSQTLQYFPRGEV--PGRK 1261
            N  P  F          PG  G P       +  +K     P Q     P GE   PG  
Sbjct: 1307 NPGPVGFPGD-------PGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPP 1359

Query: 1262 QPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGP-GPVGTPDIPLGTAPSMPGHNPMR--P 1318
              +GP PG +  +G  GE+  +      G  G  GPVG P  P G     PG   +R  P
Sbjct: 1360 GKRGP-PGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVG-PQGPAGK----PGPEGLRGIP 1413

Query: 1319 PAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAA--------VGMI--PGK-----DR 1363
                +QG+ G   +   P     PG P L  +P +         +G+I  PG+     DR
Sbjct: 1414 GPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDR 1473

Query: 1364 GPAGLYTHPG------------PVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGM 1411
            G  G    PG            P+G PG    + G  GP+ N        P G   D G+
Sbjct: 1474 GLPGTQGSPGAKGDGGIPGPAGPLGPPGPP-GLPGPQGPKGN---KGSTGPAGQKGDSGL 1529

Query: 1412 GGFSQGPGNPGNMM 1425
             G    PG PG ++
Sbjct: 1530 PGPPGSPGPPGEVI 1543



 Score =  107 bits (268), Expect = 6e-23
 Identities = 280/1140 (24%), Positives = 371/1140 (32%), Gaps = 189/1140 (16%)

Query: 420  PGPRTDVG--APFGPQGHRDVPFSPDEMVP---PSMNSQSGTIGPDHLDHMTPEQIAWLK 474
            PGP    G   P G QG    P  P +  P   P +    G  GP     M P +     
Sbjct: 444  PGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDG 503

Query: 475  LQQEFYEEKRRKQEQVVVQQCSL----------------------------QDMMVHQHG 506
             +       +  Q Q ++QQ  +                            +       G
Sbjct: 504  SKGPTI-SAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGESGDPGPQG 562

Query: 507  PRGVVRGPPPPYQMTPSEG--WAPGGT----EPFSDGINMPHSLP----------PRGMA 550
            PRG V+GPP P       G   A GG     EP + G      LP           RG  
Sbjct: 563  PRG-VQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQ 621

Query: 551  PHPNMPGSQ-MR----------LPGFAGMINSEMEGP-NVPNPASRPGLSGVSWPDDVPK 598
              P  PG   MR          LPG AG     + GP   P    +PG++GV  P   PK
Sbjct: 622  GPPGPPGDDGMRGEDGEIGPRGLPGEAG--PRGLLGPRGTPGAPGQPGMAGVDGPPG-PK 678

Query: 599  ---IPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPS 655
                P G   PPGQ    GP   +  P PQG           EK     PG+A  G+ P 
Sbjct: 679  GNMGPQGEPGPPGQQGNPGP---QGLPGPQGPIGPP-----GEKGPQGKPGLA--GL-PG 727

Query: 656  MEMNRMIPG--SQRHMEPGNNPIFPRIPV--EGPLSPSRGDFPKGIPPQMGPGRELEFGM 711
             +     PG   Q   +    P  P+ P+   GP      D  +G+    G   E  F  
Sbjct: 728  ADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGF-- 785

Query: 712  VPSGMKGDVNLNVNMGSNSQMIPQ-----KMREAGAGPEEMLKLRPGGSDMLPAQQKMVP 766
               G KGD+ L  + G   Q+ P+     +  +  AGP       PG S     + K+  
Sbjct: 786  --PGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTG----DPGPSGQAGEKGKLGV 839

Query: 767  LPFGEHPQQEYGMGPRPFLPMSQGPGSNS-----------GLRNLREPIGPDQRTNSRLS 815
                 +P ++   GP+        PG+N            G R  R P GP     +R  
Sbjct: 840  PGLPGYPGRQ---GPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGP 896

Query: 816  HMPPLPLNPSSNPTSLNTAPPVQRGL--GRKPLDISVAGSQVHSPGINPLKSPTMHQVQS 873
               P P   S         PP +RG    + P+           PG + L      + ++
Sbjct: 897  TGKPGPKGTSGGDGP--PGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGET 954

Query: 874  PMLGSPS----GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAP 929
               G       G +  PQ P+   G + G         PP  G         K  +   P
Sbjct: 955  GFQGKTGPPGPGGVVGPQGPTGETGPI-GERGHPGPPGPP--GEQGLPGAAGKEGAKGDP 1011

Query: 930  SPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPS 989
             P   S    P    G P     P    +P + G     GPP P  S        GS  +
Sbjct: 1012 GPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGER----GSAGT 1067

Query: 990  STPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPS 1049
            + P  +P  P   Q P      + +        P   D ++        + PA SP    
Sbjct: 1068 AGPIGLPGRPG-PQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDG 1126

Query: 1050 MN---NMPGMGINTQNPRISGP--NPVVPMPTLSP--------------MGMTQPLSHSN 1090
                   PG   +  +   +GP   P +  P  +P               GM        
Sbjct: 1127 DKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEG 1186

Query: 1091 QMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQ 1150
                P   GP I   G+P  PG    N  +G      P  P+G  G P G    Q PP  
Sbjct: 1187 ARGFPGPPGP-IGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQG-PNGADGPQGPPGS 1244

Query: 1151 VPFPHNGPSGGQGSFPGGMGFPGE----GPLGRPSNLPQSSADAALCKPGGPGGPDSFTV 1206
            V         G+    G  G PGE    GP G      ++    A   PG  G P     
Sbjct: 1245 VGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGP 1304

Query: 1207 LGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEK-----PSQTLQYFPRGEV--PG 1259
             GN  P  F          PG  G P       +  +K     P Q     P GE   PG
Sbjct: 1305 KGNPGPVGFPGD-------PGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPG 1357

Query: 1260 RKQPQGPGPGFSHMQGMMGEQAPRMGLALPG-MGGPGPVGTPDIPLGTAPSMPGHNPMR- 1317
                +GP PG +  +G  GE+  +      G  G  GPVG P  P G     PG   +R 
Sbjct: 1358 PPGKRGP-PGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVG-PQGPAG----KPGPEGLRG 1411

Query: 1318 -PPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAA--------AVGMI-PGKDRGPAG 1367
             P    +QG+ G   +   P     PG P L  +P +         +G+I P  ++G  G
Sbjct: 1412 IPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKG 1471

Query: 1368 LYTHPGPVGSPGM-----MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
                PG  GSPG      +    G +GP     +P    P+G     G  G     G PG
Sbjct: 1472 DRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPG 1531



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 268/1077 (24%), Positives = 351/1077 (32%), Gaps = 186/1077 (17%)

Query: 454  SGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQ----DMMV------- 502
            SGT  P+ ++ +  E+     L  E Y+ +R+  E  + +   +     D++V       
Sbjct: 326  SGTNEPNPVEEIFTEEY----LTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGDLGEY 381

Query: 503  --HQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQM 560
              +++         PP  +  P     P  T+     IN   +   +G    P +    M
Sbjct: 382  DFYEYKEYEDKPTSPPNEEFGPG---VPAETDITETSINGHGAYGEKGQKGEPAVVEPGM 438

Query: 561  RLPGFAGMINSE--MEGPNVPNPASRPGLSGVSWPDDVPKIP--DGRNFPPGQGI---FS 613
             + G  G       M  P +  P   PG  G   P   P +P  DG   PPG  +   F 
Sbjct: 439  LVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFR 498

Query: 614  GPGRGERFPNPQGLSEEMFQQQLAEKQLGL--PPG-MAMEGIRPSMEMNRMIPGSQRHM- 669
              G G + P      E   Q  L + ++ L  PPG M + G RP         G++    
Sbjct: 499  YGGDGSKGPTISA-QEAQAQAILQQARIALRGPPGPMGLTG-RPGPVGGPGSSGAKGESG 556

Query: 670  EPGNNPIFPRIPVEGPLSPS-----RG----DFPKGIPPQMGPGRELEFGMVPSGMKGDV 720
            +PG  P  PR  V+GP  P+     RG    D  +G+P + G   +  F  +P G+ GD 
Sbjct: 557  DPG--PQGPR-GVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLP-GLPGDK 612

Query: 721  NLNVNMGSNSQMIP---QKMR----EAG-------AGPEEMLKLRPGGSDMLPAQQKMVP 766
                  G      P     MR    E G       AGP  +L   P G+   P Q  M  
Sbjct: 613  GHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLG--PRGTPGAPGQPGMAG 670

Query: 767  LPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSR----LSHMPPL-- 820
            +     P+   G    P  P  QG     GL   + PIGP      +    L+ +P    
Sbjct: 671  VDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADG 730

Query: 821  -PLNPSSNPTSLN---TAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPML 876
             P +P     S       PP  +G    P    V G+     G+  LK     + +    
Sbjct: 731  PPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGAD----GVRGLKGSKGEKGEDGFP 786

Query: 877  GSPSG-NLKSPQTPSQLAGMLA-----GPAAAASIKSPPVLGSAAASPVHLKSPSLPAPS 930
            G      LK  +      G        GP   A     P     A     L  P LP   
Sbjct: 787  GFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPG-Y 845

Query: 931  PGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSS 990
            PG    PK     PG P  +            G     GP  P  S+ A        P  
Sbjct: 846  PG-RQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKG 904

Query: 991  TP-YTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARS--PNL 1047
            T     PP P   + P          F  P   P                PP +   P  
Sbjct: 905  TSGGDGPPGPPGERGPQG--PQGPVGFPGPKGPP---------------GPPGKDGLPGH 947

Query: 1048 PSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGV 1107
            P      G    T  P   GP  VV      P G T P+        P   G      G+
Sbjct: 948  PGQRGETGFQGKTGPP---GPGGVV--GPQGPTGETGPIGERGHPGPPGPPG----EQGL 998

Query: 1108 PMGPGLMSHNPIMGHGSQEPPMVPQGRMGFP--QGFPPVQSPPQQVPFPHNGPSGGQG-- 1163
            P   G        G         P G  GFP  +G P  Q  P        G  GG+G  
Sbjct: 999  PGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAP--------GLKGGEGPQ 1050

Query: 1164 SFPGGMGFPGE-------GPLGRPSNL-PQSSADAALCK-------PGGPGGPDSFT--- 1205
              PG +G PGE       GP+G P    PQ     A  K       P GP G D      
Sbjct: 1051 GPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPV 1110

Query: 1206 -VLGNSMP--SVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQ 1262
             + G + P  S   D D  E+  PG  G  + D     P   P        +G V     
Sbjct: 1111 GLPGPAGPAGSPGEDGDKGEIGEPGQKG-SKGDKGENGPPGPPGL------QGPVGAPGI 1163

Query: 1263 PQGPG-PGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHN----PMR 1317
              G G PG    QGM G++        P  G PGP+G   +P    P   G N    PM 
Sbjct: 1164 AGGDGEPGPRGQQGMFGQKGDEGARGFP--GPPGPIGLQGLP--GPPGEKGENGDVGPMG 1219

Query: 1318 PPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPG-KDRGPAGLYTHPGPVG 1376
            PP     G  GP      P  +  P        P  +VG + G  ++G  G   +PGP G
Sbjct: 1220 PPG--PPGPRGP----QGPNGADGP------QGPPGSVGSVGGVGEKGEPGEAGNPGPPG 1267

Query: 1377 SPGM-----------MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
              G+                G  GP      P    P+G    VG  G    PG PG
Sbjct: 1268 EAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPG 1324



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 183/717 (25%), Positives = 234/717 (32%), Gaps = 121/717 (16%)

Query: 261  PAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQG 320
            P P  K   P  P  R   G + K     G P     + P G    + P      P    
Sbjct: 936  PGPPGKDGLPGHPGQRGETGFQGK----TGPPGPGGVVGPQGPTGETGPIGERGHP---- 987

Query: 321  SNSSSADPKAPPPPPVSSGEPPTLGEN-------PDGLSQEQLEHRERSLQTLRDIQRML 373
                      PP PP   G P   G+        P G+S +      R            
Sbjct: 988  ---------GPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRG----------- 1027

Query: 374  FPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQ 433
            FP E+   GAQ G P    G  +GPQ  P GP+ +   +  +   GP        P GP 
Sbjct: 1028 FPGERGLPGAQ-GAPGLKGG--EGPQGPP-GPVGSPGERGSAGTAGPIGLPGRPGPQGPP 1083

Query: 434  GHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQ 493
            G      +P E  P     + G  GP  L    P   A         E+  + +     Q
Sbjct: 1084 GPAGEKGAPGEKGPQGPAGRDGVQGPVGLP--GPAGPAGSP-----GEDGDKGEIGEPGQ 1136

Query: 494  QCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDG-INMPHSLPPRGMAPH 552
            + S  D    ++GP     GPP       + G A G  EP   G   M       G    
Sbjct: 1137 KGSKGDK--GENGP----PGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGF 1190

Query: 553  PNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIF 612
            P  PG  + L G  G    + E  +V  P   PG  G   P   P   DG   PPG  + 
Sbjct: 1191 PGPPG-PIGLQGLPGPPGEKGENGDV-GPMGPPGPPGPRGPQG-PNGADGPQGPPG-SVG 1246

Query: 613  SGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPG 672
            S  G GE+              +  E     PPG A  G           P  +R  +  
Sbjct: 1247 SVGGVGEK-------------GEPGEAGNPGPPGEAGVG----------GPKGERGEKGE 1283

Query: 673  NNPIFPRIPVEGPLSPSRGDFPKGIPPQMG----PGRELEFGMV-PSGMKGDVNLNVNMG 727
              P     P  G   P   D PKG P  +G    PG   E G     G+ GD   + + G
Sbjct: 1284 AGPPGAAGP-PGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPG 1342

Query: 728  SNSQMIPQKMREAGAGPEEMLKLRPG--GSDMLPAQQKMVPLPFGEHPQQEYG-MGPRPF 784
                  P    EAG       +  PG  G++    ++        E P  + G +GP   
Sbjct: 1343 QPGP--PGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGP--- 1397

Query: 785  LPMSQGPGSN---SGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGL 841
                QGP       GLR +  P+G      +     PP P+ P   P           GL
Sbjct: 1398 ----QGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLP-----------GL 1442

Query: 842  GRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAA 901
               P      G + H PG+  L  P   Q +    G P G   SP       G + GPA 
Sbjct: 1443 KGDP---GSKGEKGH-PGLIGLIGPPGEQGEKGDRGLP-GTQGSPGAKGD--GGIPGPAG 1495

Query: 902  AASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMAS 958
                  PP L      P   K  + PA   G +  P PP  SPG P     PL + S
Sbjct: 1496 PLGPPGPPGL-PGPQGPKGNKGSTGPAGQKGDSGLPGPP-GSPGPPGEVIQPLPILS 1550



 Score = 35.0 bits (79), Expect = 0.52
 Identities = 97/409 (23%), Positives = 128/409 (31%), Gaps = 87/409 (21%)

Query: 231  PKPLPQQ--PPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKL--I 286
            P P+  Q  P  P  + +N        P PP P     P     P  +  PG    +  +
Sbjct: 1194 PGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGP--QGPPGSVGSVGGV 1251

Query: 287  PSVGSPASS-TPLPPDGTGPNSTPNNR----------AVTPVSQGSNSSSADPKAPPPPP 335
               G P  +  P PP   G       R          A  P           PK  P P 
Sbjct: 1252 GEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPV 1311

Query: 336  VSSGEPPTLGE----NPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQS-GGPQQ 390
               G+P   GE      DG+  ++ E  +              P +    G     GP  
Sbjct: 1312 GFPGDPGPPGEPGPAGQDGVGGDKGEDGD--------------PGQPGPPGPSGEAGPPG 1357

Query: 391  NPGVLDGPQKK-PEGPIQAMMAQSQSLGKGP-------GPRTDVGAPFGPQGHRDVPFSP 442
             PG    P     EG      A+ ++  +GP       GP+   G P GP+G R +P   
Sbjct: 1358 PPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKP-GPEGLRGIPGPV 1416

Query: 443  DEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMV 502
             E   P    Q G  GP     M P  +  LK       EK       ++     Q    
Sbjct: 1417 GEQGLPGAAGQDGPPGP-----MGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQG--- 1468

Query: 503  HQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRL 562
             + G RG+           P    +PG      DG  +P    P G    P +PG Q   
Sbjct: 1469 -EKGDRGL-----------PGTQGSPGAK---GDG-GIPGPAGPLGPPGPPGLPGPQ--- 1509

Query: 563  PGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGI 611
             G  G   S         PA + G SG+  P   P        PPG+ I
Sbjct: 1510 -GPKGNKGS-------TGPAGQKGDSGLPGPPGSPG-------PPGEVI 1543


>gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens]
          Length = 1838

 Score =  112 bits (279), Expect = 3e-24
 Identities = 319/1347 (23%), Positives = 428/1347 (31%), Gaps = 248/1347 (18%)

Query: 230  DPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKL---- 285
            DP+ L ++P  P+ +   +++ T   P    P P     A P P   E  G E  +    
Sbjct: 282  DPEDLGKEP-TPSKKPVEAAKETTEVPEELTPTPTE---AAPMPETSEGAGKEEDVGIGD 337

Query: 286  IPSVGSPASSTPLPPD----GTGPNST-----PNNRAVTPVSQGSNSSSADPKAPPPPPV 336
               V S    TP P D    G G  +      P   A  P S    S+S++P APPP   
Sbjct: 338  YDYVPSEDYYTPSPYDDLTYGEGEENPDQPTDPGAGAEIPTSTADTSNSSNP-APPP--- 393

Query: 337  SSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLD 396
                    GE  D L  E  E      +T+R++    +    + T + S      P   D
Sbjct: 394  --------GEGADDLEGEFTE------ETIRNLDENYYDPYYDPTSSPSEIGPGMPANQD 439

Query: 397  GPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGT 456
               +   GP      + +     PG   +   P GP+G   +P  P  M P       G 
Sbjct: 440  TIYEGIGGPRGEKGQKGEPAIIEPGMLIE--GPPGPEGPAGLPGPPGTMGPTGQVGDPGE 497

Query: 457  IGP------DHLDHMTPEQIAWLKLQQEF-----------YEEKRRKQEQVVVQQCSL-- 497
             GP         D +       L L   F               +  Q Q ++QQ  L  
Sbjct: 498  RGPPGRPGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQAQAILQQARLAL 557

Query: 498  --------------------------QDMMVHQHGPRGVVRGPPPPYQMTPSEGWA---- 527
                                      +   V   GPRG V+GPP P       G A    
Sbjct: 558  RGPAGPMGLTGRPGPVGPPGSGGLKGEPGDVGPQGPRG-VQGPPGPAGKPGRRGRAGSDG 616

Query: 528  ----PGGTEPFSD-GINMPHSLPPR-------GMAPHPNMPGSQMRL------------- 562
                PG T P  D G +    LP         G +  P  PG                  
Sbjct: 617  ARGMPGQTGPKGDRGFDGLAGLPGEKGHRGDPGPSGPPGPPGDDGERGDDGEVGPRGLPG 676

Query: 563  -PGFAGMINSEMEGPNVPNPASRPGLSGV-SWPDDVPKI-PDGRNFPPGQGIFSGPGRGE 619
             PG  G++    +GP  P P   PG++G+   P     + P G   PPGQ    G    +
Sbjct: 677  EPGPRGLLGP--KGP--PGPPGPPGVTGMDGQPGPKGNVGPQGEPGPPGQ---QGNPGAQ 729

Query: 620  RFPNPQGLSEEMFQQQLAEKQLGLP--PGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIF 677
              P PQG      +    +  LG P  PGM      P        PG     + G  P  
Sbjct: 730  GLPGPQGAIGPPGE----KGPLGKPGLPGMPGADGPPGHPGKEGPPGE----KGGQGPPG 781

Query: 678  PRIPV--EGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGS------N 729
            P+ P+   GP      D  +G+    G   E  F     G KGD+ +  + G        
Sbjct: 782  PQGPIGYPGPRGVKGADGIRGLKGTKGEKGEDGF----PGFKGDMGIKGDRGEIGPPGPR 837

Query: 730  SQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQ 789
             +  P+  +  G    +   L P G         +   P  + P+   G    P  P + 
Sbjct: 838  GEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYPGRQGPKGSIGF---PGFPGAN 894

Query: 790  G-------PGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLG 842
            G       PG   G R  R P GP      R     P P   S         PP +RG  
Sbjct: 895  GEKGGRGTPG-KPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGGDGP--AGPPGERGPN 951

Query: 843  --RKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLG--SPSG--NLKSPQTPSQLAGML 896
              + P            PG + L      + ++   G   P G   +  PQ P+   G +
Sbjct: 952  GPQGPTGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPM 1011

Query: 897  AGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTM 956
             G         PP  G      +  K  +   P P        P    G P +   P  +
Sbjct: 1012 -GERGHPGPPGPP--GEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRGFPGDRGLPGPV 1068

Query: 957  ASPAMLGNVESGGPPPPTASQ----PASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSR 1012
             +  + GN    GPP P  S     PA    P  +P       PP P   +        +
Sbjct: 1069 GALGLKGNEGPPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGAPGEKGPQ 1128

Query: 1013 MSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVV 1072
                  P+        +     +    PP    +   +      G          P P  
Sbjct: 1129 -----GPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGPPGPTG 1183

Query: 1073 PMPTLSPMGMTQPLSHSNQMPSPNA----------VGPNIPP--------HGVPMGPGLM 1114
            P     P+G   P S ++  P P             GP   P         G+P  PG  
Sbjct: 1184 PQ---GPIGQPGP-SGADGEPGPRGQQGLFGQKGDEGPRGFPGPPGPVGLQGLPGPPGEK 1239

Query: 1115 SHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGE 1174
                 +G      P  P+G  G P    P Q PP  +  P      G+    G  G PGE
Sbjct: 1240 GETGDVGQMGPPGPPGPRGPSGAPGADGP-QGPPGGIGNPGAVGEKGEPGEAGEPGLPGE 1298

Query: 1175 ----GPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFT-DPDLQEVIRPGAT 1229
                GP G      +S    A   PG  G P      G+  P  F  DP       P   
Sbjct: 1299 GGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQ 1358

Query: 1230 GIPEFDLSRIIPSEKPSQTLQYFPRGE-----VPGRKQPQGP-GPGFSHMQGMMGEQAPR 1283
              P  D        +P QT    P GE      PG++ P GP GP     +G  GE+  +
Sbjct: 1359 DGPPGDKG---DDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGP-----EGRQGEKGAK 1410

Query: 1284 MGLALPG-MGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMP 1342
                L G  G  GP+G    P G AP  PG + +R       G+ GP      P      
Sbjct: 1411 GEAGLEGPPGKTGPIG----PQG-APGKPGPDGLR-------GIPGPVGEQGLPGSPGPD 1458

Query: 1343 GQPTLMSNPAAAVGMIPG--KDRGPAGLYTHP---GPVGSPGMM--MSMQGMMGPQQNIM 1395
            G P  M  P      +PG   D GP G   HP   G +G PG       +G+ GPQ +  
Sbjct: 1459 GPPGPMGPPG-----LPGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGS-- 1511

Query: 1396 IPPQMRPRGMAADVGMGGFSQGPGNPG 1422
                  P+G     G  G    PG PG
Sbjct: 1512 ----SGPKGEQGITGPSGPIGPPGPPG 1534



 Score =  105 bits (262), Expect = 3e-22
 Identities = 255/983 (25%), Positives = 322/983 (32%), Gaps = 203/983 (20%)

Query: 506  GPRGVVR-----GPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLP-PRGMAPHPNMPGSQ 559
            GPRG++      GPP P  +T  +G      +P   G   P   P P G   +P   G  
Sbjct: 679  GPRGLLGPKGPPGPPGPPGVTGMDG------QPGPKGNVGPQGEPGPPGQQGNPGAQG-- 730

Query: 560  MRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGE 619
              LPG  G I      P    P  +PGL G+   D  P  P G+  PPG+    GP   +
Sbjct: 731  --LPGPQGAIGP----PGEKGPLGKPGLPGMPGADGPPGHP-GKEGPPGEKGGQGPPGPQ 783

Query: 620  R---FPNPQGLSEEMFQQQLAEKQLGLP--PGMAMEGIRPSMEMNRMIPGSQRHMEPGNN 674
                +P P+G+         A+   GL    G   E   P  + +  I G +  + P   
Sbjct: 784  GPIGYPGPRGVKG-------ADGIRGLKGTKGEKGEDGFPGFKGDMGIKGDRGEIGPPG- 835

Query: 675  PIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPS--------GMKGDVNLNVNM 726
               PR   +GP  P     P G P  +GP  E     VP         G KG +      
Sbjct: 836  ---PR-GEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYPGRQGPKGSIGFPGFP 891

Query: 727  GSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLP 786
            G+N +       + G G       +PG     P  Q+    P GE        GPR  + 
Sbjct: 892  GANGE-------KGGRGTPG----KPG-----PRGQRGPTGPRGER-------GPRG-IT 927

Query: 787  MSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNT-APPVQRGLGRKP 845
               GP  NSG      P GP           P  P  P+  P       PP + GL   P
Sbjct: 928  GKPGPKGNSGGDG---PAGPPGERG------PNGPQGPTGFPGPKGPPGPPGKDGLPGHP 978

Query: 846  LDISVAGSQVHS-----PGINPLKSPT-----MHQVQSPMLGSPSGN-----------LK 884
                  G Q  +     PG+   + PT     M +   P    P G             K
Sbjct: 979  GQRGETGFQGKTGPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTK 1038

Query: 885  SPQTPSQLAGM--------------LAGPAAAASIKS---PPVLGSAAASPVHLKSPSLP 927
                P+ L G               L GP  A  +K    PP     A SP   + P+  
Sbjct: 1039 GDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGE-RGPAGA 1097

Query: 928  APSPGWTSSPKPPLQSPGIP------PNHKAPLTMAS-PAMLGNVESGGP-----PPPTA 975
            A   G    P P  Q P  P      P  K P   A    + G V   GP     PP   
Sbjct: 1098 AGPIGIPGRPGP--QGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGED 1155

Query: 976  SQPASVNIPGSLPSSTPYTM--PPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVA 1033
                 +  PG   S        PP PT  Q P+          +     P          
Sbjct: 1156 GDKGEIGEPGQKGSKGDKGEQGPPGPTGPQGPIG-----QPGPSGADGEPGPRGQQGLFG 1210

Query: 1034 SSDDDSP-----PARSPNLPSMNNMPG-MGINTQNPRISGPNPVVPMPTLSPMGMTQPLS 1087
               D+ P     P     L  +   PG  G      ++  P P  P       G   P  
Sbjct: 1211 QKGDEGPRGFPGPPGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQG 1270

Query: 1088 HSNQMPSPNAVG----------PNIPPHGVPMGP-GLMSHNPIMGHGSQEPPMVPQGRMG 1136
                + +P AVG          P +P  G P GP G        G      P  P+G  G
Sbjct: 1271 PPGGIGNPGAVGEKGEPGEAGEPGLPGEGGPPGPKGERGEKGESGPSGAAGPPGPKGPPG 1330

Query: 1137 F--------PQGFPPVQSPPQQV-PFPHNGPSGGQGSF--PGGMGFPGEGPLGRPSNLPQ 1185
                     P GFP    PP +  P   +GP G +G    PG  G PG      P+  P 
Sbjct: 1331 DDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPG------PTGEPG 1384

Query: 1186 SSADAALCKPGGPGGPDSFTVLGNSMPSVFTD--PDLQEVIRP-GATGIPEFDLSRIIPS 1242
             S       P GP GP+       +      +  P     I P GA G P  D  R IP 
Sbjct: 1385 PSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPG 1444

Query: 1243 EKPSQTLQYFPRGEVPGRKQPQGP-GP-GFSHMQGMMGEQAPRMGLALPGM----GGPGP 1296
                Q L        PG   P GP GP G   + G+ G+  P+     PG+    G PG 
Sbjct: 1445 PVGEQGL--------PGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHPGLIGLIGPPGE 1496

Query: 1297 VGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVG 1356
             G           +PG      P   +QG+ GP   +  P    +PG P     P  A G
Sbjct: 1497 QGEKG-----DRGLPGPQGSSGPKG-EQGITGPSGPIGPPGPPGLPGPP----GPKGAKG 1546

Query: 1357 MIPGKDRGPAGLYTHPGPVGSPG 1379
                   GP G   HPGP G PG
Sbjct: 1547 S--SGPTGPKGEAGHPGPPGPPG 1567



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 187/768 (24%), Positives = 235/768 (30%), Gaps = 164/768 (21%)

Query: 241  PANQDQNSSQNTRLQPTPP-IPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLP 299
            P  +  N  Q     P P   P P  K   P  P  R   G + K  P         P P
Sbjct: 945  PGERGPNGPQGPTGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGP---------PGP 995

Query: 300  PDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGEN-------PDGLS 352
            P   GP          P  +           PP PP   G P   G+        P GL 
Sbjct: 996  PGVVGPQG--------PTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTKGDPGPAGLP 1047

Query: 353  QEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSG-------GPQQNPGVLDGP-QKKPEG 404
             +      R            FP ++   G           GP   PG    P ++ P G
Sbjct: 1048 GKDGPPGLRG-----------FPGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAG 1096

Query: 405  PIQAMMAQSQSLGKGP-GPRTDVGAPF--GPQGH--RD-------VPFSPDEMVPPSMNS 452
                +    +   +GP GP  + GAP   GPQG   RD       +P     + PP  + 
Sbjct: 1097 AAGPIGIPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDG 1156

Query: 453  QSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVR 512
              G IG        P Q             K  K EQ        Q   + Q GP G   
Sbjct: 1157 DKGEIGE-------PGQKG----------SKGDKGEQGPPGPTGPQGP-IGQPGPSGADG 1198

Query: 513  GPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSE 572
             P P  Q          G   F      P    P G+   P  PG +    G  G +  +
Sbjct: 1199 EPGPRGQQGLFGQKGDEGPRGF------PGPPGPVGLQGLPGPPGEK----GETGDVG-Q 1247

Query: 573  MEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMF 632
            M  P  P P    G  G           DG   PPG       G G    NP  + E+  
Sbjct: 1248 MGPPGPPGPRGPSGAPGA----------DGPQGPPG-------GIG----NPGAVGEKGE 1286

Query: 633  QQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGD 692
              +  E      PG+  EG  P  +  R   G          P        GP  P   D
Sbjct: 1287 PGEAGE------PGLPGEGGPPGPKGERGEKGESGPSGAAGPP--------GPKGPPGDD 1332

Query: 693  FPKGIPPQMG----PGRELEFGMV----PSGMKGDVNLNVNMGSNSQMIPQKMREAGAG- 743
             PKG P  +G    PG   E G      P G KGD       GS     P    E G   
Sbjct: 1333 GPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGS-----PGPTGEPGPSG 1387

Query: 744  -PEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYG-MGPRPFLPMSQGPGSNSGLRNLR 801
             P +     P G +    ++        E P  + G +GP+   P   GP    GLR + 
Sbjct: 1388 PPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQG-APGKPGP---DGLRGIP 1443

Query: 802  EPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGIN 861
             P+G      S     PP P+ P   P     + P               G + H PG+ 
Sbjct: 1444 GPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGP--------------KGEKGH-PGLI 1488

Query: 862  PLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGM--LAGPAAAASIKSPPVLGSAAASPV 919
             L  P   Q +    G P      PQ  S   G   + GP+       PP L      P 
Sbjct: 1489 GLIGPPGEQGEKGDRGLP-----GPQGSSGPKGEQGITGPSGPIGPPGPPGL-PGPPGPK 1542

Query: 920  HLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVES 967
              K  S P    G    P PP   PG P     PL + +     N+++
Sbjct: 1543 GAKGSSGPTGPKGEAGHPGPP-GPPGPPGEVIQPLPIQASRTRRNIDA 1589



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 66/244 (27%), Positives = 85/244 (34%), Gaps = 43/244 (17%)

Query: 233  PLPQQPPAPANQD-------------QNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESP 279
            P P   P PA QD             Q  S     +P P  P     P  P  P  R+  
Sbjct: 1347 PGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGRQGE 1406

Query: 280  GVENKLIPSVGSPASSTPLPPDGTGPNSTPNN-RAVT-PVSQGSNSSSADPKAPPPPPVS 337
                      G P  + P+ P G      P+  R +  PV +     S  P  PP P   
Sbjct: 1407 KGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGP 1466

Query: 338  SGEPPTLGENPD----------GLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSG- 386
             G P   G++            GL     E  E+  + L   Q    P  ++     SG 
Sbjct: 1467 PGLPGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSSGPKGEQGITGPSGP 1526

Query: 387  -GPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGP-GPRTDVGAPFGPQGHRDVPFSPDE 444
             GP   PG L GP   P+G      A+  S   GP GP+ + G P GP G    P  P E
Sbjct: 1527 IGPPGPPG-LPGP-PGPKG------AKGSS---GPTGPKGEAGHP-GPPG---PPGPPGE 1571

Query: 445  MVPP 448
            ++ P
Sbjct: 1572 VIQP 1575



 Score = 35.4 bits (80), Expect = 0.40
 Identities = 38/156 (24%), Positives = 52/156 (33%), Gaps = 31/156 (19%)

Query: 1296 PVGTPDIPLGTAPSMPGHNPMRPPAF----------------LQQGMMGPHHRMMSPAQS 1339
            P    +IP  TA +    NP  PP                  L +    P++   S    
Sbjct: 370  PGAGAEIPTSTADTSNSSNPAPPPGEGADDLEGEFTEETIRNLDENYYDPYYDPTSSPSE 429

Query: 1340 TMPGQPTLMSNPAAAVGMIPGKDRGPAG----------LYTHPGPVGSPGMMMSMQGMMG 1389
              PG P         +G  P  ++G  G          +   PGP G  G+     G MG
Sbjct: 430  IGPGMPANQDTIYEGIGG-PRGEKGQKGEPAIIEPGMLIEGPPGPEGPAGLP-GPPGTMG 487

Query: 1390 PQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMM 1425
            P   +  P +  P G     G+ G    PG PG M+
Sbjct: 488  PTGQVGDPGERGPPGRP---GLPGADGLPGPPGTML 520



 Score = 31.2 bits (69), Expect = 7.5
 Identities = 22/79 (27%), Positives = 31/79 (39%), Gaps = 1/79 (1%)

Query: 12   PSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGH 71
            P G T  +    +     PP      G P L  K   +G  G +    +  P   + G  
Sbjct: 1001 PQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLR-GFP 1059

Query: 72   TPKALPGPGGSMGLKNGAG 90
              + LPGP G++GLK   G
Sbjct: 1060 GDRGLPGPVGALGLKGNEG 1078



 Score = 30.8 bits (68), Expect = 9.7
 Identities = 20/61 (32%), Positives = 25/61 (40%), Gaps = 1/61 (1%)

Query: 30   PPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGA 89
            PP  M P G P L      +G++G         P   + G    + LPGP GS G K   
Sbjct: 1460 PPGPMGPPGLPGLKGDSGPKGEKGHPGLIGLIGP-PGEQGEKGDRGLPGPQGSSGPKGEQ 1518

Query: 90   G 90
            G
Sbjct: 1519 G 1519


>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1487

 Score =  106 bits (265), Expect = 1e-22
 Identities = 306/1242 (24%), Positives = 400/1242 (32%), Gaps = 196/1242 (15%)

Query: 258  PPIPAPAPKPAAPPRPLDRES-PGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTP 316
            P  P      +  P P  ++  PG    ++   G P    P    G   +         P
Sbjct: 87   PICPTDLATASGQPGPKGQKGEPGDIKDIVGPKGPPGPQGPAGEQGPRGDRGDKGEKGAP 146

Query: 317  VSQGSNSSSADPKAPPPP-PVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFP 375
              +G +     P  P PP P     PP LG N         + +    Q L  +Q  + P
Sbjct: 147  GPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQ-LGVMQGPMGP 205

Query: 376  DEKEFTGAQSGGP-----QQNPGV-----LDGPQ--KKPEGPIQAMMAQSQSLGKGPGPR 423
                     +G P     Q NPG      + GP   + P GP           GK PG  
Sbjct: 206  MGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGP-PGKPGDDGEAGK-PGKA 263

Query: 424  TDVGAPFGPQGHRDVPFSPD------------------EMVPPSMNSQSGTIGPDHLDHM 465
             + G P GPQG R  P +P                   E   P +  +SG+ G    ++ 
Sbjct: 264  GERGPP-GPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPG----ENG 318

Query: 466  TPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPY------Q 519
            +P  +    L  E    +         +    Q       GP G   GP  P       +
Sbjct: 319  SPGPMGPRGLPGE--RGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGE 376

Query: 520  MTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPN---MPGSQ--MRLPGFAGMINSEME 574
              P+    P G +        P S  P G + +P    +PG++     PG AG       
Sbjct: 377  AGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAG------- 429

Query: 575  GPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPG--RGERFP-NPQGLSEEM 631
             P  P P   PG  G + P      P G+   PG   F G    +GE  P  PQG     
Sbjct: 430  APGFPGPRGPPGPQGATGPLG----PKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPA 485

Query: 632  FQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRG 691
             ++     + G P G+   G  P  E  R  PG++    PG + +       G   PS  
Sbjct: 486  GEEGKRGAR-GEPGGVGPIG--PPGE--RGAPGNRGF--PGQDGLAGPKGAPGERGPSGL 538

Query: 692  DFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLR 751
              PKG      PGR  E G+   G +G      + G   ++ P         P E  +  
Sbjct: 539  AGPKGANGD--PGRPGEPGL--PGARGLTGRPGDAGPQGKVGPS------GAPGEDGRPG 588

Query: 752  PGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQG----PGSNSGLRNLREPIGPD 807
            P G      Q  ++  P  +    E G      LP + G    PG + G      P GP 
Sbjct: 589  PPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKD-GETGAAGPPGPA 647

Query: 808  QRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPT 867
                 R     P P      P      PP   G G KP D  V G +  +PG   L  P 
Sbjct: 648  GPAGERGEQGAPGPSGFQGLP-----GPPGPPGEGGKPGDQGVPG-EAGAPG---LVGPR 698

Query: 868  MHQVQSPMLGSPSGNLKSPQTPSQLAGM--------LAGPAAAASIKSPPVLGSAAASPV 919
              +      GSP    +  Q P  L G          +GPA     + PP L      P 
Sbjct: 699  GERGFPGERGSPGA--QGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGL---QGMPG 753

Query: 920  HLKSPSLPAPSPGWTS-SPKPPLQSPGIPPNHKAPLTMASPAMLG-NVESG--GPPPPTA 975
               +  +  P         K P  +PG          +  P   G N E G  GPP P  
Sbjct: 754  ERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAG 813

Query: 976  SQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASS 1035
            S  A        P     T PP P              + FA P                
Sbjct: 814  SAGAR-----GAPGERGETGPPGP--------------AGFAGPPGA------------- 841

Query: 1036 DDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSP 1095
             D  P A+     +           Q P    P P  P     P G             P
Sbjct: 842  -DGQPGAKGEQGEAGQKGDAGAPGPQGPS-GAPGPQGPTGVTGPKGARGAQGPPGATGFP 899

Query: 1096 NAVGPNIPP--HGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPF 1153
             A G   PP  +G P  PG    +   G         P GR G P    P   P ++   
Sbjct: 900  GAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEP 959

Query: 1154 PHNGPSGGQGSFPGGMGFPGE-GPLGRPSN--------LPQSSADAALCKPGGPGGPDSF 1204
              +GPSG +G  PG  G  G+ G +G P          LP  S +    K G PG     
Sbjct: 960  GDDGPSGAEGP-PGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPG--KQGAPGASGDR 1016

Query: 1205 TVLGNSMPSVFTDP--DLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQ 1262
               G   P   T P  +      PGA G P  D +  +  +          RGE      
Sbjct: 1017 GPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGD----------RGETGAVGA 1066

Query: 1263 PQGPGP-GFSHMQGMMGEQAPRMGLALPGMGGP-GPVGTPDIPLGTAPSMPGHNPMRPPA 1320
            P  PGP G     G  G+Q  R      G  GP GP G   I     P         P  
Sbjct: 1067 PGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPG- 1125

Query: 1321 FLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGM 1380
              ++G+ G  HR  +  Q  +PG P    +  A+    P   RGP      PGPVG  G 
Sbjct: 1126 --ERGLKG--HRGFTGLQG-LPGPPGPSGDQGASGPAGPSGPRGP------PGPVGPSGK 1174

Query: 1381 MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
                 G+ GP    + PP   PRG + + G  G    PG PG
Sbjct: 1175 D-GANGIPGP----IGPPG--PRGRSGETGPAGPPGNPGPPG 1209



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 223/957 (23%), Positives = 307/957 (32%), Gaps = 154/957 (16%)

Query: 9    RSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKS 68
            R+ P+G   +     Q     PP  + P+G P        +G+ G       P+      
Sbjct: 334  RTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAG-------PTGARGPE 386

Query: 69   GGHTPKALPGPGGSMGLKNGAGN-------GAKGKGKRERSISADSFD--------QRDP 113
            G   P+  PG  GS G    +GN       GAKG         A  F         Q   
Sbjct: 387  GAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGAT 446

Query: 114  GTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNATAP------RSSTPSHGQTTATEPT 167
            G         E   A     Q  +  P    P  A  P      R +    G      P 
Sbjct: 447  GPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPP 506

Query: 168  PAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISAL 227
              +  P    +     +A        +G    +      N    +      P    ++  
Sbjct: 507  GERGAPGNRGFPGQDGLAGPKGAPGERGP-SGLAGPKGANGDPGRPGEPGLPGARGLTGR 565

Query: 228  RNDPKPLPQQPPAPANQDQN-----SSQNTRLQP-TPPIPAPAPKPAAPPRPLDRESPGV 281
              D  P  +  P+ A  +         Q  R QP     P P      P +  ++  PG 
Sbjct: 566  PGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGA 625

Query: 282  EN-KLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGE 340
               + +P       +   PP   GP      +     + G +     P  PP PP   G+
Sbjct: 626  PGLRGLPGKDGETGAAG-PPGPAGPAGERGEQG----APGPSGFQGLP-GPPGPPGEGGK 679

Query: 341  PPTLGENPDGLSQEQLEHR-ERSLQTLRDIQRMLFPDEKEFTGAQS-GGPQQNPGV--LD 396
            P   G   +  +   +  R ER            FP E+   GAQ   GP+  PG    D
Sbjct: 680  PGDQGVPGEAGAPGLVGPRGERG-----------FPGERGSPGAQGLQGPRGLPGTPGTD 728

Query: 397  GPQ--KKPEGP--------IQAMMAQSQSLG-KGP-GPRTDVG----------------- 427
            GP+    P GP        +Q M  +  + G  GP G R DVG                 
Sbjct: 729  GPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLT 788

Query: 428  APFGPQGHRDVPFSPDEMVPPSMNSQSGTIG-PDHLDHMTPEQIAWLKLQQEFYEEKRRK 486
             P GP G         E+ PP     +G  G P       P   A          +   K
Sbjct: 789  GPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAK 848

Query: 487  QEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGI-NMPHSLP 545
             EQ    Q         Q GP G   GP  P  +T  +G       P + G       + 
Sbjct: 849  GEQGEAGQKGDAGAPGPQ-GPSGAP-GPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVG 906

Query: 546  PRGMAPHPNMPGSQMRLPGFAGMINSEM----EGPNVPNPASRPGLSGVSWP-------- 593
            P G   +P  PG     PG +G    +      GP  P  A  PGL G + P        
Sbjct: 907  PPGSNGNPGPPGP----PGPSGKDGPKGARGDSGP--PGRAGEPGLQGPAGPPGEKGEPG 960

Query: 594  DDVPKIPDGRNFPPG----QGIFSGPG-RGER-FPNPQGLSEEMFQQQL--AEKQLGLPP 645
            DD P   +G   P G    +GI   PG RGER FP   G S E  +Q    A    G P 
Sbjct: 961  DDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPG 1020

Query: 646  GMAMEGIR-PSMEMNRM-IPGSQRHMEPGNNP---IFPRIPVEGPLSPSRGDFPKGIPPQ 700
             +   G+  P+ E  R   PG+     PG +    +       G +       P G P  
Sbjct: 1021 PVGPPGLTGPAGEPGREGSPGADG--PPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGP 1078

Query: 701  MGP-GRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMR----EAGAGPEEMLKLRPGGS 755
             GP G++ + G   +G +G +  +   G+     PQ  R    EAG   E  LK   G +
Sbjct: 1079 AGPTGKQGDRG--EAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFT 1136

Query: 756  DMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLS 815
             +     + +P P G  P  + G         + GP   SG R    P+GP  +  +   
Sbjct: 1137 GL-----QGLPGPPG--PSGDQG---------ASGPAGPSGPRGPPGPVGPSGKDGANGI 1180

Query: 816  HMPPLPLNPSSNPTSL-------NTAPPVQRGLGRKPLDISV-AGSQVHSPGINPLK 864
              P  P  P              N  PP   G     +D+S  AG      G +PL+
Sbjct: 1181 PGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPDPLQ 1237



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 66/245 (26%), Positives = 82/245 (33%), Gaps = 62/245 (25%)

Query: 1219 DLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGE---------VPGRKQPQGPGPG 1269
            D+++ + P    IP  +   I P++  + + Q  P+G+         + G K P GP   
Sbjct: 71   DVKDCLSPE---IPFGECCPICPTDLATASGQPGPKGQKGEPGDIKDIVGPKGPPGP--- 124

Query: 1270 FSHMQGMMGEQAPRMGLALPG-MGGPGPVGTPDIPLGTA--PSMPGH-NPMRPPAF---- 1321
                QG  GEQ PR      G  G PGP G    P GT   P  PG   P  PP      
Sbjct: 125  ----QGPAGEQGPRGDRGDKGEKGAPGPRGRDGEP-GTPGNPGPPGPPGPPGPPGLGGNF 179

Query: 1322 ------------------LQQGMMGPHHRMMSPAQSTMPGQPTLMSNPA------AAVGM 1357
                              + QG MGP      P  +  PG      NP        +  M
Sbjct: 180  AAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPM 239

Query: 1358 IPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQG 1417
             P    GP G     G  G PG      G  GP      P     RG     G+ G    
Sbjct: 240  GPRGPPGPPGKPGDDGEAGKPG----KAGERGP------PGPQGARGFPGTPGLPGVKGH 289

Query: 1418 PGNPG 1422
             G PG
Sbjct: 290  RGYPG 294



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 67/273 (24%), Positives = 96/273 (35%), Gaps = 47/273 (17%)

Query: 504  QHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSD-------GINMPHSLPPRGMAPHPNMP 556
            Q G RG    P P  +  P +  APG +            G+  P   P R  +P  + P
Sbjct: 988  QRGERGFPGLPGPSGE--PGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGP 1045

Query: 557  GSQMRLPGFAGMINSEME-----GPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGI 611
              +    G AG+     E      P  P P   PG +G +      +   G   P G   
Sbjct: 1046 PGR---DGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQG-DRGEAGAQGPMGP-- 1099

Query: 612  FSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMI----PGSQR 667
             SGP        PQG   +       + + G P    ++G R    +  +     P   +
Sbjct: 1100 -SGPAGARGIQGPQGPRGD-------KGEAGEPGERGLKGHRGFTGLQGLPGPPGPSGDQ 1151

Query: 668  HMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGP----GRELEFGMV-------PSGM 716
                   P  PR P  GP+ PS  D   GIP  +GP    GR  E G         P G 
Sbjct: 1152 GASGPAGPSGPRGP-PGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGP 1210

Query: 717  KGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLK 749
             G     ++M + + + P   RE G  P + ++
Sbjct: 1211 PGPPGPGIDMSAFAGLGP---REKGPDPLQYMR 1240



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 70/271 (25%), Positives = 91/271 (33%), Gaps = 55/271 (20%)

Query: 234  LPQQPPAPANQDQNSSQNTRLQPTPPIP----APAPKPAAPPRPLDRESPGVENKL---- 285
            LP     P  Q    +   R  P P  P     PA +P     P     PG +       
Sbjct: 997  LPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKG 1056

Query: 286  ----IPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEP 341
                  +VG+P +  P PP   GP          P  +  +   A  + P  P   +G  
Sbjct: 1057 DRGETGAVGAPGA--PGPPGSPGPAG--------PTGKQGDRGEAGAQGPMGPSGPAGAR 1106

Query: 342  PTLG-ENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQS----GGPQQNPGVLD 396
               G + P G   E  E  ER L+  R            FTG Q      GP  + G   
Sbjct: 1107 GIQGPQGPRGDKGEAGEPGERGLKGHRG-----------FTGLQGLPGPPGPSGDQGA-S 1154

Query: 397  GPQ--KKPEGPIQAMMAQSQSLGKG-------PGPRTDVG--APFGPQGHRDVPFSPDEM 445
            GP     P GP   +    +    G       PGPR   G   P GP G+   P  P   
Sbjct: 1155 GPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPP 1214

Query: 446  VPP-SMNSQSG----TIGPDHLDHMTPEQIA 471
             P   M++ +G      GPD L +M  +Q A
Sbjct: 1215 GPGIDMSAFAGLGPREKGPDPLQYMRADQAA 1245



 Score = 32.3 bits (72), Expect = 3.3
 Identities = 28/95 (29%), Positives = 35/95 (36%), Gaps = 7/95 (7%)

Query: 30  PPTVMSPSGNPQLDSKFSNQGKQG--GSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKN 87
           PP    P G P L   F+ Q   G    A  +Q        G   P+  PGP G+ G + 
Sbjct: 163 PPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQG 222

Query: 88  GAGN-GAKGKGKRERSISADSFDQRDPGTPNDDSD 121
             GN G  G    E  +S     +  PG P    D
Sbjct: 223 FQGNPGEPG----EPGVSGPMGPRGPPGPPGKPGD 253



 Score = 30.8 bits (68), Expect = 9.7
 Identities = 40/185 (21%), Positives = 57/185 (30%), Gaps = 38/185 (20%)

Query: 3   SSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQG-----GSAS 57
           +  PK  S P+G               PP    P G   +  +    G  G     G   
Sbjct: 727 TDGPKGASGPAG---------------PPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVG 771

Query: 58  QSQPSPCDSKSGGHT---PKALPGPGGSMGLKNGAGN-------GAKGK-GKRERS---- 102
           +  P     K GG     P   PGP G+ G K   G        GA+G  G+R  +    
Sbjct: 772 EKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPG 831

Query: 103 ---ISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHG 159
               +        PG   +  +  +   A     Q     P    P+  T P+ +  + G
Sbjct: 832 PAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQG 891

Query: 160 QTTAT 164
              AT
Sbjct: 892 PPGAT 896


>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
            sapiens]
          Length = 1418

 Score =  105 bits (261), Expect = 4e-22
 Identities = 302/1220 (24%), Positives = 393/1220 (32%), Gaps = 195/1220 (15%)

Query: 279  PGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPP-PVS 337
            PG    ++   G P    P    G   +         P  +G +     P  P PP P  
Sbjct: 40   PGDIKDIVGPKGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGNPGPPGPPG 99

Query: 338  SGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGP-----QQNP 392
               PP LG N         + +    Q L  +Q  + P         +G P     Q NP
Sbjct: 100  PPGPPGLGGNFAAQMAGGFDEKAGGAQ-LGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNP 158

Query: 393  GV-----LDGPQ--KKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPD-- 443
            G      + GP   + P GP           GK PG   + G P GPQG R  P +P   
Sbjct: 159  GEPGEPGVSGPMGPRGPPGP-PGKPGDDGEAGK-PGKAGERGPP-GPQGARGFPGTPGLP 215

Query: 444  ----------------EMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQ 487
                            E   P +  +SG+ G    ++ +P  +    L  E    +    
Sbjct: 216  GVKGHRGYPGLDGAKGEAGAPGVKGESGSPG----ENGSPGPMGPRGLPGE--RGRTGPA 269

Query: 488  EQVVVQQCSLQDMMVHQHGPRGVVRGPPPPY------QMTPSEGWAPGGTEPFSDGINMP 541
                 +    Q       GP G   GP  P       +  P+    P G +        P
Sbjct: 270  GAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTP 329

Query: 542  HSLPPRGMAPHPN---MPGSQ--MRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDV 596
             S  P G + +P    +PG++     PG AG        P  P P   PG  G + P   
Sbjct: 330  GSPGPAGASGNPGTDGIPGAKGSAGAPGIAG-------APGFPGPRGPPGPQGATGPLG- 381

Query: 597  PKIPDGRNFPPGQGIFSGPG--RGERFP-NPQGLSEEMFQQQLAEKQLGLPPGMAMEGIR 653
               P G+   PG   F G    +GE  P  PQG      ++     + G P G+   G  
Sbjct: 382  ---PKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGAR-GEPGGVGPIG-- 435

Query: 654  PSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVP 713
            P  E  R  PG++    PG + +       G   PS    PKG      PGR  E G+  
Sbjct: 436  PPGE--RGAPGNRGF--PGQDGLAGPKGAPGERGPSGLAGPKGANGD--PGRPGEPGL-- 487

Query: 714  SGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHP 773
             G +G      + G   ++ P         P E  +  P G      Q  ++  P  +  
Sbjct: 488  PGARGLTGRPGDAGPQGKVGPS------GAPGEDGRPGPPGPQGARGQPGVMGFPGPKGA 541

Query: 774  QQEYGMGPRPFLPMSQG----PGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPT 829
              E G      LP + G    PG + G      P GP      R     P P      P 
Sbjct: 542  NGEPGKAGEKGLPGAPGLRGLPGKD-GETGAAGPPGPAGPAGERGEQGAPGPSGFQGLP- 599

Query: 830  SLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTP 889
                 PP   G G KP D  V G +  +PG   L  P   +      GSP    +  Q P
Sbjct: 600  ----GPPGPPGEGGKPGDQGVPG-EAGAPG---LVGPRGERGFPGERGSPGA--QGLQGP 649

Query: 890  SQLAGM--------LAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTS-SPKPP 940
              L G          +GPA     + PP L      P    +  +  P         K P
Sbjct: 650  RGLPGTPGTDGPKGASGPAGPPGAQGPPGL---QGMPGERGAAGIAGPKGDRGDVGEKGP 706

Query: 941  LQSPGIPPNHKAPLTMASPAMLG-NVESG--GPPPPTASQPASVNIPGSLPSSTPYTMPP 997
              +PG          +  P   G N E G  GPP P  S  A        P     T PP
Sbjct: 707  EGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGAR-----GAPGERGETGPP 761

Query: 998  EPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMG 1057
             P              + FA P                 D  P A+     +        
Sbjct: 762  GP--------------AGFAGPPGA--------------DGQPGAKGEQGEAGQKGDAGA 793

Query: 1058 INTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPP--HGVPMGPGLMS 1115
               Q P    P P  P     P G             P A G   PP  +G P  PG   
Sbjct: 794  PGPQGPS-GAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPG 852

Query: 1116 HNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGE- 1174
             +   G         P GR G P    P   P ++     +GPSG +G  PG  G  G+ 
Sbjct: 853  PSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGP-PGPQGLAGQR 911

Query: 1175 GPLGRPSN--------LPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDP--DLQEVI 1224
            G +G P          LP  S +    K G PG        G   P   T P  +     
Sbjct: 912  GIVGLPGQRGERGFPGLPGPSGEPG--KQGAPGASGDRGPPGPVGPPGLTGPAGEPGREG 969

Query: 1225 RPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGP-GFSHMQGMMGEQAPR 1283
             PGA G P  D +  +  +          RGE      P  PGP G     G  G+Q  R
Sbjct: 970  SPGADGPPGRDGAAGVKGD----------RGETGAVGAPGAPGPPGSPGPAGPTGKQGDR 1019

Query: 1284 MGLALPGMGGP-GPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMP 1342
                  G  GP GP G   I     P         P    ++G+ G  HR  +  Q  +P
Sbjct: 1020 GEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPG---ERGLKG--HRGFTGLQG-LP 1073

Query: 1343 GQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRP 1402
            G P    +  A+    P   RGP      PGPVG  G      G+ GP    + PP   P
Sbjct: 1074 GPPGPSGDQGASGPAGPSGPRGP------PGPVGPSGKD-GANGIPGP----IGPPG--P 1120

Query: 1403 RGMAADVGMGGFSQGPGNPG 1422
            RG + + G  G    PG PG
Sbjct: 1121 RGRSGETGPAGPPGNPGPPG 1140



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 223/957 (23%), Positives = 307/957 (32%), Gaps = 154/957 (16%)

Query: 9    RSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKS 68
            R+ P+G   +     Q     PP  + P+G P        +G+ G       P+      
Sbjct: 265  RTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAG-------PTGARGPE 317

Query: 69   GGHTPKALPGPGGSMGLKNGAGN-------GAKGKGKRERSISADSFD--------QRDP 113
            G   P+  PG  GS G    +GN       GAKG         A  F         Q   
Sbjct: 318  GAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGAT 377

Query: 114  GTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNATAP------RSSTPSHGQTTATEPT 167
            G         E   A     Q  +  P    P  A  P      R +    G      P 
Sbjct: 378  GPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPP 437

Query: 168  PAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISAL 227
              +  P    +     +A        +G    +      N    +      P    ++  
Sbjct: 438  GERGAPGNRGFPGQDGLAGPKGAPGERGP-SGLAGPKGANGDPGRPGEPGLPGARGLTGR 496

Query: 228  RNDPKPLPQQPPAPANQDQN-----SSQNTRLQP-TPPIPAPAPKPAAPPRPLDRESPGV 281
              D  P  +  P+ A  +         Q  R QP     P P      P +  ++  PG 
Sbjct: 497  PGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGA 556

Query: 282  EN-KLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGE 340
               + +P       +   PP   GP      +     + G +     P  PP PP   G+
Sbjct: 557  PGLRGLPGKDGETGAAG-PPGPAGPAGERGEQG----APGPSGFQGLP-GPPGPPGEGGK 610

Query: 341  PPTLGENPDGLSQEQLEHR-ERSLQTLRDIQRMLFPDEKEFTGAQS-GGPQQNPGV--LD 396
            P   G   +  +   +  R ER            FP E+   GAQ   GP+  PG    D
Sbjct: 611  PGDQGVPGEAGAPGLVGPRGERG-----------FPGERGSPGAQGLQGPRGLPGTPGTD 659

Query: 397  GPQ--KKPEGP--------IQAMMAQSQSLG-KGP-GPRTDVG----------------- 427
            GP+    P GP        +Q M  +  + G  GP G R DVG                 
Sbjct: 660  GPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLT 719

Query: 428  APFGPQGHRDVPFSPDEMVPPSMNSQSGTIG-PDHLDHMTPEQIAWLKLQQEFYEEKRRK 486
             P GP G         E+ PP     +G  G P       P   A          +   K
Sbjct: 720  GPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAK 779

Query: 487  QEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGI-NMPHSLP 545
             EQ    Q         Q GP G   GP  P  +T  +G       P + G       + 
Sbjct: 780  GEQGEAGQKGDAGAPGPQ-GPSGAP-GPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVG 837

Query: 546  PRGMAPHPNMPGSQMRLPGFAGMINSEM----EGPNVPNPASRPGLSGVSWP-------- 593
            P G   +P  PG     PG +G    +      GP  P  A  PGL G + P        
Sbjct: 838  PPGSNGNPGPPGP----PGPSGKDGPKGARGDSGP--PGRAGEPGLQGPAGPPGEKGEPG 891

Query: 594  DDVPKIPDGRNFPPG----QGIFSGPG-RGER-FPNPQGLSEEMFQQQL--AEKQLGLPP 645
            DD P   +G   P G    +GI   PG RGER FP   G S E  +Q    A    G P 
Sbjct: 892  DDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPG 951

Query: 646  GMAMEGIR-PSMEMNRM-IPGSQRHMEPGNNP---IFPRIPVEGPLSPSRGDFPKGIPPQ 700
             +   G+  P+ E  R   PG+     PG +    +       G +       P G P  
Sbjct: 952  PVGPPGLTGPAGEPGREGSPGADG--PPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGP 1009

Query: 701  MGP-GRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMR----EAGAGPEEMLKLRPGGS 755
             GP G++ + G   +G +G +  +   G+     PQ  R    EAG   E  LK   G +
Sbjct: 1010 AGPTGKQGDRG--EAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFT 1067

Query: 756  DMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLS 815
             +     + +P P G  P  + G         + GP   SG R    P+GP  +  +   
Sbjct: 1068 GL-----QGLPGPPG--PSGDQG---------ASGPAGPSGPRGPPGPVGPSGKDGANGI 1111

Query: 816  HMPPLPLNPSSNPTSL-------NTAPPVQRGLGRKPLDISV-AGSQVHSPGINPLK 864
              P  P  P              N  PP   G     +D+S  AG      G +PL+
Sbjct: 1112 PGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPDPLQ 1168



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 67/273 (24%), Positives = 96/273 (35%), Gaps = 47/273 (17%)

Query: 504  QHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSD-------GINMPHSLPPRGMAPHPNMP 556
            Q G RG    P P  +  P +  APG +            G+  P   P R  +P  + P
Sbjct: 919  QRGERGFPGLPGPSGE--PGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGP 976

Query: 557  GSQMRLPGFAGMINSEME-----GPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGI 611
              +    G AG+     E      P  P P   PG +G +      +   G   P G   
Sbjct: 977  PGR---DGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQG-DRGEAGAQGPMGP-- 1030

Query: 612  FSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMI----PGSQR 667
             SGP        PQG   +       + + G P    ++G R    +  +     P   +
Sbjct: 1031 -SGPAGARGIQGPQGPRGD-------KGEAGEPGERGLKGHRGFTGLQGLPGPPGPSGDQ 1082

Query: 668  HMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGP----GRELEFGMV-------PSGM 716
                   P  PR P  GP+ PS  D   GIP  +GP    GR  E G         P G 
Sbjct: 1083 GASGPAGPSGPRGP-PGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGP 1141

Query: 717  KGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLK 749
             G     ++M + + + P   RE G  P + ++
Sbjct: 1142 PGPPGPGIDMSAFAGLGP---REKGPDPLQYMR 1171



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 70/271 (25%), Positives = 91/271 (33%), Gaps = 55/271 (20%)

Query: 234  LPQQPPAPANQDQNSSQNTRLQPTPPIP----APAPKPAAPPRPLDRESPGVENKL---- 285
            LP     P  Q    +   R  P P  P     PA +P     P     PG +       
Sbjct: 928  LPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKG 987

Query: 286  ----IPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEP 341
                  +VG+P +  P PP   GP          P  +  +   A  + P  P   +G  
Sbjct: 988  DRGETGAVGAPGA--PGPPGSPGPAG--------PTGKQGDRGEAGAQGPMGPSGPAGAR 1037

Query: 342  PTLG-ENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQS----GGPQQNPGVLD 396
               G + P G   E  E  ER L+  R            FTG Q      GP  + G   
Sbjct: 1038 GIQGPQGPRGDKGEAGEPGERGLKGHRG-----------FTGLQGLPGPPGPSGDQGA-S 1085

Query: 397  GPQ--KKPEGPIQAMMAQSQSLGKG-------PGPRTDVG--APFGPQGHRDVPFSPDEM 445
            GP     P GP   +    +    G       PGPR   G   P GP G+   P  P   
Sbjct: 1086 GPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPP 1145

Query: 446  VPP-SMNSQSG----TIGPDHLDHMTPEQIA 471
             P   M++ +G      GPD L +M  +Q A
Sbjct: 1146 GPGIDMSAFAGLGPREKGPDPLQYMRADQAA 1176



 Score = 32.3 bits (72), Expect = 3.3
 Identities = 28/95 (29%), Positives = 35/95 (36%), Gaps = 7/95 (7%)

Query: 30  PPTVMSPSGNPQLDSKFSNQGKQG--GSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKN 87
           PP    P G P L   F+ Q   G    A  +Q        G   P+  PGP G+ G + 
Sbjct: 94  PPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQG 153

Query: 88  GAGN-GAKGKGKRERSISADSFDQRDPGTPNDDSD 121
             GN G  G    E  +S     +  PG P    D
Sbjct: 154 FQGNPGEPG----EPGVSGPMGPRGPPGPPGKPGD 184



 Score = 30.8 bits (68), Expect = 9.7
 Identities = 40/185 (21%), Positives = 57/185 (30%), Gaps = 38/185 (20%)

Query: 3   SSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQG-----GSAS 57
           +  PK  S P+G               PP    P G   +  +    G  G     G   
Sbjct: 658 TDGPKGASGPAG---------------PPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVG 702

Query: 58  QSQPSPCDSKSGGHT---PKALPGPGGSMGLKNGAGN-------GAKGK-GKRERS---- 102
           +  P     K GG     P   PGP G+ G K   G        GA+G  G+R  +    
Sbjct: 703 EKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPG 762

Query: 103 ---ISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHG 159
               +        PG   +  +  +   A     Q     P    P+  T P+ +  + G
Sbjct: 763 PAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQG 822

Query: 160 QTTAT 164
              AT
Sbjct: 823 PPGAT 827


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score =  105 bits (261), Expect = 4e-22
 Identities = 330/1314 (25%), Positives = 411/1314 (31%), Gaps = 343/1314 (26%)

Query: 235  PQQPPAPANQDQNSS-QNTRLQPTPP-IPAPAPKPAAPPRPLDRESPGVENKLIPSVGSP 292
            PQ P AP         Q  +  P PP IP     P  P +P    SPG           P
Sbjct: 89   PQPPTAPTRPPNGQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGP 148

Query: 293  ASSTPL-----------------------PPDGTGPNSTPNNRAV--TPVSQG--SNSSS 325
             + +P                        PP   GP  T  +     +P  QG       
Sbjct: 149  QNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQ 208

Query: 326  ADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRML----FPD----- 376
            A P  PP PP + G     G+  DG S       ER L     I+       FP      
Sbjct: 209  AGPSGPPGPPGAIGPSGPAGK--DGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHR 266

Query: 377  -------EKEFTGA-----QSGGPQQN--PGVLDGPQKKPEGPIQAMMAQSQSLGKGPGP 422
                   EK  TGA     ++G P +N  PG + GP+  P    +  +  +       G 
Sbjct: 267  GFDGRNGEKGETGAPGLKGENGLPGENGAPGPM-GPRGAPGERGRPGLPGAAGARGNDGA 325

Query: 423  RTDVGAPF--GPQGHRDVPFSPD---EMVP---PSMNS---QSGTIGPD-HLDHMTPEQI 470
            R   G P   GP G    P SP    E+ P   P  N    Q G  GP  H     P   
Sbjct: 326  RGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGP 385

Query: 471  AWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGV--------VRGPPPPYQMTP 522
              +        E                       GP G+         RGPP P     
Sbjct: 386  PGINGSPGGKGEM----------------------GPAGIPGAPGLMGARGPPGPAGANG 423

Query: 523  SEGWAPGGTEPFSDGIN-MPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEG-----P 576
            + G   G  EP  +G    P     RG A  P +PG++    G  G   S  E      P
Sbjct: 424  APGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAK----GEDGKDGSPGEPGANGLP 479

Query: 577  NVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQL 636
                    PG  G + P+ +P    G   P G+    GP        P+G + E  +   
Sbjct: 480  GAAGERGAPGFRGPAGPNGIP----GEKGPAGERGAPGPA------GPRGAAGEPGRD-- 527

Query: 637  AEKQLGLPPGMAMEGIR-----PSMEMNRMIPGSQ----RHMEPGNNPIFPRIPVEGPLS 687
                 G+P G  M G+      P  +     PGSQ    R   PG +    +  V G   
Sbjct: 528  -----GVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPG 582

Query: 688  PSRGDF----------PKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKM 737
            P   D           P G  PQ  PG+  E G  P G  G      + G      PQ +
Sbjct: 583  PKGNDGAPGKNGERGGPGGPGPQGPPGKNGETG--PQGPPGPTGPGGDKGDTGPPGPQGL 640

Query: 738  REA-GAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEH--PQQEYGMGPRPFLPMSQGPGSN 794
            +   G G        P G +  P +    P P G+   P    G G     P  +GP   
Sbjct: 641  QGLPGTGG-------PPGENGKPGE----PGPKGDAGAPGAPGGKGDAG-APGERGPPGL 688

Query: 795  SGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQ 854
            +G   LR   GP      + +  PP P   +  P  L   P  + GLG            
Sbjct: 689  AGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTP-GLQGMPGERGGLG------------ 735

Query: 855  VHSPGINPLKSPTMHQVQSPMLGSPSG----NLKSPQTPSQLAGMLAGPAAAASIKSPPV 910
              SPG    K            G P G     +     P    G +  P  A     P  
Sbjct: 736  --SPGPKGDK------------GEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQ---PGD 778

Query: 911  LGSAAASPVHLKSPSLPAP--SPG--WTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVE 966
             G   A  +    P +  P  SPG    + P  P   PG P  +  P         G   
Sbjct: 779  KGEGGAPGL----PGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKG 834

Query: 967  SGGPP----PPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSST 1022
             GGPP    PP  S PA    PG          P  P  +  P            +P   
Sbjct: 835  EGGPPGVAGPPGGSGPAGP--PGPQGVKGERGSPGGPGAAGFP--------GARGLPGPP 884

Query: 1023 PLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQ---NPRISGPNPVVPMPTLSP 1079
                       S+ +  PP  S + P  +  PG   NT    +P +SGP      P    
Sbjct: 885  ----------GSNGNPGPPGPSGS-PGKDGPPGPAGNTGAPGSPGVSGPKGDAGQP---- 929

Query: 1080 MGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMG-HGSQEPPMVPQGRMGFP 1138
                       +  SP A GP       P  PG +    I G  G   PP +P      P
Sbjct: 930  ----------GEKGSPGAQGP-------PGAPGPLGIAGITGARGLAGPPGMPG-----P 967

Query: 1139 QGFPPVQSPPQQVPFPH-NGPSGGQGSFPGGMGFPG-EGPLGRPSNLPQSSADAALCKPG 1196
            +G P  Q    +   P  NG SG +G  PG  G PG  G  G P       +D    + G
Sbjct: 968  RGSPGPQGVKGESGKPGANGLSGERGP-PGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDG 1026

Query: 1197 GPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGE 1256
             PGG                  D  E   PGA G P            P       P G+
Sbjct: 1027 SPGGKG----------------DRGENGSPGAPGAPGH----------PGPPGPVGPAGK 1060

Query: 1257 VPGRKQ--PQGPG--PGFSHMQGMMGEQAPRMGLALPGMGGPGPV----GTPDIPLGTAP 1308
               R +  P GP   PG +  +G  G Q PR      G  G   +    G P  P   AP
Sbjct: 1061 SGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNP--GAP 1118

Query: 1309 SMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGL 1368
              PG      PA  QQG +G      SP  +  P  P   S P       PGKD    G 
Sbjct: 1119 GSPG------PAG-QQGAIG------SPGPAG-PRGPVGPSGP-------PGKD----GT 1153

Query: 1369 YTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
              HPGP+G PG                      PRG   + G  G    PG PG
Sbjct: 1154 SGHPGPIGPPG----------------------PRGNRGERGSEGSPGHPGQPG 1185



 Score = 97.4 bits (241), Expect = 8e-20
 Identities = 286/1111 (25%), Positives = 354/1111 (31%), Gaps = 195/1111 (17%)

Query: 417  GKGP-GPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKL 475
            G+GP GP+ D G P G  G    P  P +   P      G+ GP  +    P        
Sbjct: 101  GQGPQGPKGDPGPP-GIPGRNGDPGIPGQPGSP------GSPGPPGICESCPTGPQNYSP 153

Query: 476  QQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFS 535
            Q + Y+ K      V V        +    GP G   GPP P    P     PG   P S
Sbjct: 154  QYDSYDVK----SGVAVGG------LAGYPGPAGPP-GPPGP----PGTSGHPGS--PGS 196

Query: 536  DGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDD 595
             G   P   P +     P  P   +   G AG  + E   P  P     PG  G+  P  
Sbjct: 197  PGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGK-DGESGRPGRPGERGLPGPPGIKGPAG 255

Query: 596  VPKIP--------DGRNFPPGQGIFSGPG-RGER-FPNPQGLSEEMFQQQLAEKQLGLPP 645
            +P  P        DGRN   G+     PG +GE   P   G    M  +  A  + G P 
Sbjct: 256  IPGFPGMKGHRGFDGRNGEKGET--GAPGLKGENGLPGENGAPGPMGPRG-APGERGRPG 312

Query: 646  GMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIP-VEGPLSPSRGDFPKGIPPQMG-P 703
                 G R + +  R   G      P     FP  P  +G + P+      G P Q G P
Sbjct: 313  LPGAAGARGN-DGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEP 371

Query: 704  GRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAG-----------AGPEEMLKLRP 752
            G +   G    G  G   +N + G   +M P  +  A            AG      LR 
Sbjct: 372  GPQGHAGA--QGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGLRG 429

Query: 753  GGSDMLPAQQKMVPLPFGEHPQQ----------EYGMGPRPFLPMSQG-PGS--NSGLRN 799
            G  +      K  P P GE  +           E G    P  P + G PG+    G   
Sbjct: 430  GAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPG 489

Query: 800  LREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAP--PVQRGLGRKPLDISVAGSQVHS 857
             R P GP    N       P     +  P     A   P + G+   P    + GS    
Sbjct: 490  FRGPAGP----NGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSP-GG 544

Query: 858  PGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAAS 917
            PG +    P   Q +S   G P      P  P    G++  P    +  +P   G     
Sbjct: 545  PGSDGKPGPPGSQGESGRPGPPG-----PSGPRGQPGVMGFPGPKGNDGAPGKNGERGGP 599

Query: 918  PVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQ 977
                  P  P    G T    PP   P  P   K       P  L  +   G PP    +
Sbjct: 600  GG--PGPQGPPGKNGETGPQGPP--GPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGK 655

Query: 978  PAS------VNIPGSLPSSTPYTMPPE---PTLSQNPLSIMMSRMSKFAMPSSTPLYHDA 1028
            P           PG+         P E   P L+  P               + P   + 
Sbjct: 656  PGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAP----------GLRGGAGPPGPEG 705

Query: 1029 IKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVP----MPTLS-PMGMT 1083
             K  A        A +P L  M    G G+ +  P+     P  P    +P    P G T
Sbjct: 706  GKGAAGPPGPPGAAGTPGLQGMPGERG-GLGSPGPKGDKGEPGGPGADGVPGKDGPRGPT 764

Query: 1084 QPLSHSNQMPSPNAVG----PNIP-------------------PHGVPMGPGLMSHNPIM 1120
             P+        P   G    P +P                   P G P  PG   +    
Sbjct: 765  GPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPG--QNGEPG 822

Query: 1121 GHGSQEPPMV-----PQGRMGFPQGFPPVQSP-PQQVPFPHNGPSG-GQGSFPGGMGFPG 1173
            G G +  P       P G  G P G  P   P PQ V      P G G   FPG  G PG
Sbjct: 823  GKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPG 882

Query: 1174 E-GPLGRPSNLPQSSADAALCKPG--GPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATG 1230
              G  G P     S +      PG  GP GP   T    S               PG +G
Sbjct: 883  PPGSNGNPGPPGPSGS------PGKDGPPGPAGNTGAPGS---------------PGVSG 921

Query: 1231 IPEFDLSRIIPSEKPSQTLQYFPRGEVP----------GRKQPQG-PGP-GFSHMQGMMG 1278
             P+ D  +  P EK S   Q  P    P          G   P G PGP G    QG+ G
Sbjct: 922  -PKGDAGQ--PGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKG 978

Query: 1279 EQAPRMGLALPG-MGGPGPVGTPDIPLGTA-----PSMPGHNPMRPPAFLQQGMMGPHHR 1332
            E        L G  G PGP G P +  GTA        PG + + P      G  G    
Sbjct: 979  ESGKPGANGLSGERGPPGPQGLPGLA-GTAGEPGRDGNPGSDGL-PGRDGSPGGKGDRGE 1036

Query: 1333 MMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQ 1392
              SP     PG P     P   VG  P    G  G     GP G+PG   S +G  GPQ 
Sbjct: 1037 NGSPGAPGAPGHP----GPPGPVG--PAGKSGDRGESGPAGPAGAPGPAGS-RGAPGPQG 1089

Query: 1393 NIMIPPQMRPRGMAADVGMGGFSQGPGNPGN 1423
                  +   RG A   G  GF   PG PG+
Sbjct: 1090 PRGDKGETGERGAAGIKGHRGFPGNPGAPGS 1120



 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 131/509 (25%), Positives = 171/509 (33%), Gaps = 72/509 (14%)

Query: 937  PKPPLQSPGIPPNHKAPL-TMASPAMLGNVESGGPP--PPTASQPASVNIPGSLPS--ST 991
            P+PP  +P  PPN + P      P   G     G P  P     P S   PG   S  + 
Sbjct: 89   PQPPT-APTRPPNGQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTG 147

Query: 992  PYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMN 1051
            P    P+         + +  ++ +  P+  P                PP  S + P   
Sbjct: 148  PQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPP------------GPPGPPGTSGH-PGSP 194

Query: 1052 NMPGMGINTQNPRISGPN-PVVPMPTLSPMGMTQPLSHSNQMPSPNAVG-PNIP----PH 1105
              PG       P  +GP+ P  P   + P G       S +   P   G P  P    P 
Sbjct: 195  GSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPA 254

Query: 1106 GVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSF 1165
            G+P  PG+  H    G   ++      G  G   G P     P        GP G +G+ 
Sbjct: 255  GIPGFPGMKGHRGFDGRNGEKGETGAPGLKG-ENGLPGENGAP--------GPMGPRGA- 304

Query: 1166 PGGMGFPG-EGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVI 1224
            PG  G PG  G  G   N     +D    +PG PG P +    G+        P      
Sbjct: 305  PGERGRPGLPGAAGARGNDGARGSDG---QPGPPGPPGTAGFPGSPGAKGEVGP----AG 357

Query: 1225 RPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRM 1284
             PG+ G P              Q  +  P+G   G + P GP PG +   G  GE  P  
Sbjct: 358  SPGSNGAP-------------GQRGEPGPQGHA-GAQGPPGP-PGINGSPGGKGEMGPAG 402

Query: 1285 GLALPGM----GGPGPVGTPDIP-LGTAPSMPGHN-----PMRPPAFLQQGMMGPHHRMM 1334
                PG+    G PGP G    P L      PG N     P       + G+ G      
Sbjct: 403  IPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKG 462

Query: 1335 SPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNI 1394
               +   PG+P     P AA        RGPAG    PG  G  G      G  GP+   
Sbjct: 463  EDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGER-GAPGPAGPRGAA 521

Query: 1395 MIPPQMRPRGMAADVGMGGFSQGPGNPGN 1423
              P +    G+    GM G    PG PG+
Sbjct: 522  GEPGR---DGVPGGPGMRGMPGSPGGPGS 547



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 247/1044 (23%), Positives = 307/1044 (29%), Gaps = 272/1044 (26%)

Query: 229  NDPKPLPQQPPAPA----------------NQDQNSSQNTRLQPTPPIPAPAPKPAAPPR 272
            +D +P P  PP  A                +   N +   R +P P   A A  P  PP 
Sbjct: 328  SDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPG 387

Query: 273  PLDRESPGVENKLIPSVGSPASSTPL----PPDGTGPNSTP-----------NNRAVTPV 317
                 SPG + ++ P+ G P +   +    PP   G N  P           N     P 
Sbjct: 388  I--NGSPGGKGEMGPA-GIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPG 444

Query: 318  SQGSNSSSADPKAP-----------PPPPVSSGEPPTLGEN----------PDGLSQEQL 356
             +G    +  P  P           P  P ++G P   GE           P+G+  E+ 
Sbjct: 445  PRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKG 504

Query: 357  EHRERSLQ-------TLRDIQRMLFPDEKEFTG--AQSGGP----QQNPGVLDGPQKKPE 403
               ER             +  R   P      G     GGP    +  P    G   +P 
Sbjct: 505  PAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPG 564

Query: 404  GPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLD 463
             P  +       +   PGP+ + GAP G  G R  P  P    PP  N ++G  GP    
Sbjct: 565  PPGPSGPRGQPGVMGFPGPKGNDGAP-GKNGERGGPGGPGPQGPPGKNGETGPQGPP--- 620

Query: 464  HMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGV-----VRGPPPP- 517
                                                      GP G        GPP P 
Sbjct: 621  ------------------------------------------GPTGPGGDKGDTGPPGPQ 638

Query: 518  -YQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGP 576
              Q  P  G  PG           P    P+G A  P  PG +    G AG       GP
Sbjct: 639  GLQGLPGTGGPPGEN-------GKPGEPGPKGDAGAPGAPGGK----GDAGAPGE--RGP 685

Query: 577  NVPNPASRPGLSGVSWPDDVPKIPDGRNFPPG-QGIFSGPG----RGER----FPNPQGL 627
              P  A  PGL G + P   P+   G   PPG  G    PG     GER     P P+G 
Sbjct: 686  --PGLAGAPGLRGGAGPPG-PEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKG- 741

Query: 628  SEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLS 687
                          G P G   +G          +PG      P   PI P  P   P  
Sbjct: 742  ------------DKGEPGGPGADG----------VPGKDGPRGP-TGPIGPPGPAGQPGD 778

Query: 688  PSRGDFPKGIP----PQMGPGRELEFGMV-PSGMKGDVNLNVNMGSNSQM-IPQKMREAG 741
               G  P G+P    P+  PG   E G   P+G  G    N   G   +   P +  E G
Sbjct: 779  KGEGGAP-GLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGG 837

Query: 742  ----AGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGL 797
                AGP       PGGS            P G  P    G+      P   G     G 
Sbjct: 838  PPGVAGP-------PGGSG-----------PAG--PPGPQGVKGERGSPGGPGAAGFPGA 877

Query: 798  RNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHS 857
            R L  P G         S+  P P  PS +P      PP   G                +
Sbjct: 878  RGLPGPPG---------SNGNPGPPGPSGSPG--KDGPPGPAG-------------NTGA 913

Query: 858  PGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAAS 917
            PG   +  P     Q    GSP G    P  P  L   +AG   A  +  PP +     S
Sbjct: 914  PGSPGVSGPKGDAGQPGEKGSP-GAQGPPGAPGPLG--IAGITGARGLAGPPGMPGPRGS 970

Query: 918  P----VHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPP-- 971
            P    V  +S    A        P  P   PG+        T   P   GN  S G P  
Sbjct: 971  PGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAG------TAGEPGRDGNPGSDGLPGR 1024

Query: 972  --PPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSR-MSKFAMPSSTPLYHDA 1028
               P        N     P +  +  PP P     P      R  S  A P+  P     
Sbjct: 1025 DGSPGGKGDRGENGSPGAPGAPGHPGPPGPV---GPAGKSGDRGESGPAGPAGAP----- 1076

Query: 1029 IKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSH 1088
                 +    +P  + P               +  R    NP  P       G   P   
Sbjct: 1077 ---GPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAP-------GSPGPAGQ 1126

Query: 1089 SNQMPSPNAVGPNIP--PHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQS 1146
               + SP   GP  P  P G P   G   H   +G          +G  G P G P    
Sbjct: 1127 QGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSP-GHPGQPG 1185

Query: 1147 PPQQVPFPHNGPSGGQGSFPGGMG 1170
            PP        GP G  G   GG+G
Sbjct: 1186 PP--------GPPGAPGPCCGGVG 1201



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 225/1011 (22%), Positives = 304/1011 (30%), Gaps = 226/1011 (22%)

Query: 36   PSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKG 95
            P G P ++     +G+ G +     P       G   P    G  G+ GL+ GAG   K 
Sbjct: 382  PPGPPGINGSPGGKGEMGPAGIPGAPG----LMGARGPPGPAGANGAPGLRGGAGEPGKN 437

Query: 96   KGKRERSISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSN---ATAPR 152
              K E     +  +   PG P               K +D +        +N     A  
Sbjct: 438  GAKGEPGPRGERGEAGIPGVPG-------------AKGEDGKDGSPGEPGANGLPGAAGE 484

Query: 153  SSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNK 212
               P           P +K PA                A  +G             +  +
Sbjct: 485  RGAPGFRGPAGPNGIPGEKGPA--------GERGAPGPAGPRG-------------AAGE 523

Query: 213  TERSTAPLNTQISALRNDP-KPLPQQPPAPANQDQNSSQNTRLQPTPPIPA-PAPKPAAP 270
              R   P    +  +   P  P     P P       SQ    +P PP P+ P  +P   
Sbjct: 524  PGRDGVPGGPGMRGMPGSPGGPGSDGKPGPP-----GSQGESGRPGPPGPSGPRGQPGVM 578

Query: 271  PRPLDRESPGVENKLIPSVGSPASSTPLPPDG----TGPNSTPNNRAVTPVSQGSNSSSA 326
              P  + + G   K     G P    P  P G    TGP   P      P   G +    
Sbjct: 579  GFPGPKGNDGAPGK-NGERGGPGGPGPQGPPGKNGETGPQGPPG-----PTGPGGDKGDT 632

Query: 327  DPKAPP---------PPPVSSGEPPTLGENPD----------GLSQEQLEHRERSLQTLR 367
             P  P           PP  +G+P   G   D          G +    E     L    
Sbjct: 633  GPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAP 692

Query: 368  DIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVG 427
             ++    P   E  G  + GP   PG    P       +Q M  +   LG  PGP+ D G
Sbjct: 693  GLRGGAGPPGPE-GGKGAAGPPGPPGAAGTP------GLQGMPGERGGLG-SPGPKGDKG 744

Query: 428  APFGPQGH----RDVPFSPDEMV-PPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEE 482
             P GP       +D P  P   + PP    Q G  G      +    IA           
Sbjct: 745  EPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGL--PGIA----------- 791

Query: 483  KRRKQEQVVVQQCSLQDMMVHQHGPRGV-----VRGPPPP--YQMTPSEGWAPGGT---- 531
                                   GPRG        GPP P  +   P +   PGG     
Sbjct: 792  -----------------------GPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERG 828

Query: 532  EPFSDGINMPHSL--PPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSG 589
             P   G   P  +  PP G  P    PG Q         +  E   P  P  A  PG  G
Sbjct: 829  APGEKGEGGPPGVAGPPGGSGP-AGPPGPQ--------GVKGERGSPGGPGAAGFPGARG 879

Query: 590  VSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAM 649
            +  P       +G   PPG      PG+ +  P P G               G P    +
Sbjct: 880  LPGPPG----SNGNPGPPGPS--GSPGK-DGPPGPAG-------------NTGAPGSPGV 919

Query: 650  EGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRG-DFPKGIP-PQMGPGREL 707
             G  P  +  +  PG +        P  P       ++ +RG   P G+P P+  PG   
Sbjct: 920  SG--PKGDAGQ--PGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPG--- 972

Query: 708  EFGMVPSGMKGD---VNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKM 764
                 P G+KG+      N   G      PQ +        E  +    GSD LP +   
Sbjct: 973  -----PQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGS 1027

Query: 765  VPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNP 824
               P G+  + E G    P  P   GP           P+GP  ++  R    P  P   
Sbjct: 1028 ---PGGKGDRGENGSPGAPGAPGHPGPPG---------PVGPAGKSGDRGESGPAGPAG- 1074

Query: 825  SSNPTSLNTAPPVQ--RGLGRKPLDISVAGSQVHS--PGINPLKSPTMHQVQSPMLGSPS 880
            +  P     AP  Q  RG   +  +   AG + H   PG NP          +P    P+
Sbjct: 1075 APGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPG-NP---------GAPGSPGPA 1124

Query: 881  GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSL--------PAPSPG 932
            G   +  +P       AGP        PP     +  P  +  P             SPG
Sbjct: 1125 GQQGAIGSPGP-----AGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPG 1179

Query: 933  WTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNI 983
                P PP   PG P      +  A+ A +G  ++GG  P    +P    I
Sbjct: 1180 HPGQPGPP-GPPGAPGPCCGGVGAAAIAGIGGEKAGGFAPYYGDEPMDFKI 1229



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 166/723 (22%), Positives = 217/723 (30%), Gaps = 150/723 (20%)

Query: 9    RSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKS 68
            R  P G   S P+ +  VM  P     P GN     K   +G  GG   Q  P     K+
Sbjct: 562  RPGPPG--PSGPRGQPGVMGFP----GPKGNDGAPGKNGERGGPGGPGPQGPPG----KN 611

Query: 69   GGHTPKALPGPGGSMGLKNGAG-------NGAKGKGKRERSISADSFDQRDPGTPNDDSD 121
            G   P+  PGP G  G K   G        G  G G        ++    +PG P  D+ 
Sbjct: 612  GETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTG----GPPGENGKPGEPG-PKGDAG 666

Query: 122  IKECNSADHIKSQDSQHTPHSM--TPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYV 179
                           +  P  +   P          P  G+  A  P P        +  
Sbjct: 667  APGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQG 726

Query: 180  FSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERS-TAPLNTQISALRNDPKPLPQQP 238
               E     +    KG            +      R  T P+     A +   K     P
Sbjct: 727  MPGERGGLGSPGP-KGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAP 785

Query: 239  PAPANQDQNSSQNTRLQPTPPIPAPAP----KPAAPPRPLDRESPGVENKLIPSVGSPAS 294
              P       S   R +  PP PA  P    +   P    +R +PG + +     G P  
Sbjct: 786  GLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGE-----GGPPG 840

Query: 295  STPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAP--------PPPPVSSGEPPTLGE 346
                PP G+GP   P  + V    +G   S   P A         P PP S+G P   G 
Sbjct: 841  VAG-PPGGSGPAGPPGPQGV----KGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPG- 894

Query: 347  NPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPI 406
             P G   +                     D        +G P  +PGV  GP+     P 
Sbjct: 895  -PSGSPGK---------------------DGPPGPAGNTGAP-GSPGV-SGPKGDAGQPG 930

Query: 407  QAMMAQSQSLGKG-PGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHM 465
            +          KG PG +   GAP GP G   +  +     PP M    G+ GP  +   
Sbjct: 931  E----------KGSPGAQGPPGAP-GPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGE 979

Query: 466  TPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEG 525
            + +  A                                 +G  G  RGPP P  +    G
Sbjct: 980  SGKPGA---------------------------------NGLSG-ERGPPGPQGL---PG 1002

Query: 526  WAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRP 585
             A    EP  DG      LP R  +P       +   PG  G        P  P P    
Sbjct: 1003 LAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGH----PGPPGPVGPA 1058

Query: 586  GLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPP 645
            G SG            G + P G     GP      P PQG   +       + + G   
Sbjct: 1059 GKSG----------DRGESGPAGPAGAPGPAGSRGAPGPQGPRGD-------KGETGERG 1101

Query: 646  GMAMEGIRPSMEMNRMIPGS-----QRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQ 700
               ++G R     N   PGS     Q+       P  PR PV GP  P   D   G P  
Sbjct: 1102 AAGIKGHR-GFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPV-GPSGPPGKDGTSGHPGP 1159

Query: 701  MGP 703
            +GP
Sbjct: 1160 IGP 1162


>gi|110735435 collagen, type V, alpha 3 preproprotein [Homo sapiens]
          Length = 1745

 Score =  103 bits (258), Expect = 9e-22
 Identities = 310/1281 (24%), Positives = 416/1281 (32%), Gaps = 258/1281 (20%)

Query: 264  APKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGT---GPNSTPNNRAVTPVSQG 320
            +P P +       + P  E    P+   P + TPL    T   G N+T   R++ P S G
Sbjct: 274  SPPPDSAENQTSTDIPKTET---PAPNLPPTPTPLVVTSTVTTGLNATILERSLDPDS-G 329

Query: 321  SNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEF 380
            +   + + KA        G+  T+G  PD  + E     +  +                F
Sbjct: 330  TELGTLETKAARED--EEGDDSTMG--PDFRAAEYPSRTQFQI----------------F 369

Query: 381  TGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPF 440
             GA   G +  P V++  Q+  EGP  A           PGP+  VG P GP G    P 
Sbjct: 370  PGAGEKGAKGEPAVIEKGQQF-EGPPGA-----------PGPQGVVG-PSGPPGPPGFPG 416

Query: 441  SPDEMVP---PSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSL 497
             P    P   P +    G  GP     M P Q A    +      ++  Q Q V+QQ  L
Sbjct: 417  DPGPPGPAGLPGIPGIDGIRGPPGTVIMMPFQFAGGSFKGPPVSFQQA-QAQAVLQQTQL 475

Query: 498  QDMMVHQHGPRGVVRGPPPP----YQMTPSEGWAPGGTEPFSDGINMPHSLPPR-GMAPH 552
               M    GP G+   P P     +     E  A G   P   G+  PH  P R G    
Sbjct: 476  S--MKGPPGPVGLTGRPGPVGLPGHPGLKGEEGAEGPQGP--RGLQGPHGPPGRVGKMGR 531

Query: 553  PNMPGSQMR--------------LPGFAGMINSEMEGPNV--PNPASRPGLSGVSWPDDV 596
            P   G++                LPG  G      +  +V  P P    G  G   P   
Sbjct: 532  PGADGARGLPGDTGPKGDRGFDGLPGLPGEKGQRGDFGHVGQPGPPGEDGERGAEGPPG- 590

Query: 597  PKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSM 656
               P G+   PG     GP RG   P  +     +     A+  +G PPG      +   
Sbjct: 591  ---PTGQAGEPGPRGLLGP-RGSPGPTGRPGVTGIDGAPGAKGNVG-PPGEPGPPGQQGN 645

Query: 657  EMNRMIPGSQR------HMEPGNNPIFPRIP-VEGPLSPSRGDFPKGIPPQMGPGRELEF 709
              ++ +PG Q          P  NP  P +P  +GPL     + P G     GP      
Sbjct: 646  HGSQGLPGPQGLIGTPGEKGPPGNPGIPGLPGSDGPLGHPGHEGPTGEKGAQGPPGSAG- 704

Query: 710  GMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKM-VPLP 768
               P G  G   +    G+          E G   E+      G   +   Q K   P P
Sbjct: 705  ---PPGYPGPRGVKGTSGNRGLQ-----GEKGEKGEDGFPGFKGDVGLKGDQGKPGAPGP 756

Query: 769  FGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNP 828
             GE        GP       +GP   +G      P  P          +P LP  P    
Sbjct: 757  RGED-------GP-------EGPKGQAGQAGEEGP--PGSAGEKGKLGVPGLPGYPGRPG 800

Query: 829  TSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGS-----PSGNL 883
               +   P   G    P+       +   PG+   + P   + +    G+     P G++
Sbjct: 801  PKGSIGFPGPLG----PIGEKGKSGKTGQPGLEGERGPPGSRGERGQPGATGQPGPKGDV 856

Query: 884  KSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSP-----GWTSSPK 938
                 P      + G      ++ PP        P H      P         G+     
Sbjct: 857  GQDGAPG-----IPGEKGLPGLQGPPGFPGPKGPPGHQGKDGRPGHPGQRGELGFQGQTG 911

Query: 939  PPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPG--SLPSSTPYTMP 996
            PP  +  + P  K          +G +   GPP P    P    +PG      +     P
Sbjct: 912  PPGPAGVLGPQGKT-------GEVGPLGERGPPGPPGP-PGEQGLPGLEGREGAKGELGP 963

Query: 997  PEPTLSQNPLSIMMSRMSKFAM--PSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMP 1054
            P P   + P  +      K     P  T L  D         + SP  R P  P+     
Sbjct: 964  PGPLGKEGPAGLRGFPGPKGGPGDPGPTGLKGDKGPPGPVGANGSPGERGPLGPA----G 1019

Query: 1055 GMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGV-PMGP-- 1111
            G+G+  Q+       PV P       G   P   + +   P  +GP  PP    P G   
Sbjct: 1020 GIGLPGQS---GSEGPVGPAGKKGSRGERGPPGPTGKDGIPGPLGPLGPPGAAGPSGEEG 1076

Query: 1112 -----GLMSHNPIMGH-GSQEPPMVP-----------------QGRMGFP---------- 1138
                 G   H    G  G   PP  P                 QGR G P          
Sbjct: 1077 DKGDVGAPGHKGSKGDKGDAGPPGQPGIRGPAGHPGPPGADGAQGRRGPPGLFGQKGDDG 1136

Query: 1139 -QGFPPVQSPP--QQVPFPHN-----------------------GPSGGQGS--FPGGMG 1170
             +GF  V  PP  Q +P P                         GP+G +G+   PGG+G
Sbjct: 1137 VRGFVGVIGPPGLQGLPGPPGEKGEVGDVGSMGPHGAPGPRGPQGPTGSEGTPGLPGGVG 1196

Query: 1171 FPGE-GPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGAT 1229
             PG  G  G   +        A   PG PG        G+S PS    P       PG  
Sbjct: 1197 QPGAVGEKGERGDAGDPGPPGA---PGIPGPKGDIGEKGDSGPSGAAGP-------PGKK 1246

Query: 1230 GIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALP 1289
            G P  D ++              P G +PG   P G  PG S + G  GE+        P
Sbjct: 1247 GPPGEDGAKGSVG----------PTG-LPGDLGPPGD-PGVSGIDGSPGEKGD------P 1288

Query: 1290 G-MGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQ--PT 1346
            G +GGPGP G    P   AP  PG    R P+    G MG   R         PG   P 
Sbjct: 1289 GDVGGPGPPGASGEP--GAPGPPGK---RGPS----GHMGREGREGEKGAKGEPGPDGPP 1339

Query: 1347 LMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMM-----MSMQGMMGPQQNIMIPPQMR 1401
              + P  A G  PG+  GP GL   PGPVG PG++     M   G +GP     +     
Sbjct: 1340 GRTGPMGARGP-PGRV-GPEGLRGIPGPVGEPGLLGAPGQMGPPGPLGPSGLPGLKGDTG 1397

Query: 1402 PRGMAADVGMGGFSQGPGNPG 1422
            P+G    +G+ G    PG  G
Sbjct: 1398 PKGEKGHIGLIGLIGPPGEAG 1418



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 125/494 (25%), Positives = 176/494 (35%), Gaps = 115/494 (23%)

Query: 967  SGGPPPPTASQPASVNIPGSLPSSTPY-TMPPEPT---LSQNPLSIMMSRMSKFAMPSST 1022
            +  PPP +A    S +IP    + TP   +PP PT   ++    + + + + + ++   +
Sbjct: 272  TSSPPPDSAENQTSTDIP---KTETPAPNLPPTPTPLVVTSTVTTGLNATILERSLDPDS 328

Query: 1023 PLYHDAIKTVASSDDDS-------PPARSPNLPSMNNM---PGMG---------INTQNP 1063
                  ++T A+ +D+        P  R+   PS       PG G         +  +  
Sbjct: 329  GTELGTLETKAAREDEEGDDSTMGPDFRAAEYPSRTQFQIFPGAGEKGAKGEPAVIEKGQ 388

Query: 1064 RISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHG 1123
            +  GP P  P     P G+  P         P   GP   P G+P  PG+         G
Sbjct: 389  QFEGP-PGAP----GPQGVVGPSGPPGPPGFPGDPGPP-GPAGLPGIPGI--------DG 434

Query: 1124 SQEPP----MVPQGRMGFPQGFPPV-------QSPPQQVPFPHNGPSGGQG--SFPGGMG 1170
             + PP    M+P    G     PPV       Q+  QQ      GP G  G    PG +G
Sbjct: 435  IRGPPGTVIMMPFQFAGGSFKGPPVSFQQAQAQAVLQQTQLSMKGPPGPVGLTGRPGPVG 494

Query: 1171 FPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATG 1230
             PG   L              L  P GP G                   + ++ RPGA G
Sbjct: 495  LPGHPGLKGEEGAEGPQGPRGLQGPHGPPGR------------------VGKMGRPGADG 536

Query: 1231 IPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPG 1290
                                   RG +PG   P+G   GF  + G+ GE+  R       
Sbjct: 537  A----------------------RG-LPGDTGPKGDR-GFDGLPGLPGEKGQRGDFG--H 570

Query: 1291 MGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSN 1350
            +G PGP G         P  P      P     +G++GP     SP  +  PG   +   
Sbjct: 571  VGQPGPPGEDGERGAEGPPGPTGQAGEPGP---RGLLGPRG---SPGPTGRPGVTGIDGA 624

Query: 1351 PAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVG 1410
            P A   +      GP G    PGP G  G   S QG+ GPQ  I  P +  P G     G
Sbjct: 625  PGAKGNV------GPPG---EPGPPGQQGNHGS-QGLPGPQGLIGTPGEKGPPGNPGIPG 674

Query: 1411 MGGFSQGP-GNPGN 1423
            + G S GP G+PG+
Sbjct: 675  LPG-SDGPLGHPGH 687



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 240/984 (24%), Positives = 309/984 (31%), Gaps = 236/984 (23%)

Query: 235  PQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPAS 294
            P +P  P  Q  + SQ     P P      P    PP      +PG+        G P S
Sbjct: 634  PGEPGPPGQQGNHGSQGL---PGPQGLIGTPGEKGPPG-----NPGIP-------GLPGS 678

Query: 295  STPLP-PDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQ 353
              PL  P   GP            +QG   S+  P  P P  V      T G    GL  
Sbjct: 679  DGPLGHPGHEGPTGEKG-------AQGPPGSAGPPGYPGPRGVKG----TSGNR--GLQG 725

Query: 354  EQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKK--PEGPI-QAMM 410
            E+ E  E             FP  K   G +  G Q  PG   GP+ +  PEGP  QA  
Sbjct: 726  EKGEKGEDG-----------FPGFKGDVGLK--GDQGKPGA-PGPRGEDGPEGPKGQAGQ 771

Query: 411  AQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQI 470
            A  +      G +  +G P        +P  P    P       G +GP        E+ 
Sbjct: 772  AGEEGPPGSAGEKGKLGVP-------GLPGYPGRPGPKGSIGFPGPLGP------IGEKG 818

Query: 471  AWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPG- 529
               K  Q   E +R        +    Q     Q GP+G V     P    P E   PG 
Sbjct: 819  KSGKTGQPGLEGERGPPGSRGERG---QPGATGQPGPKGDVGQDGAPG--IPGEKGLPGL 873

Query: 530  -GTEPFSDGINMPHSLPPRGMAPHPNMPGS-----QMRLPGFAGMIN-----------SE 572
             G   F      P      G   HP   G      Q   PG AG++             E
Sbjct: 874  QGPPGFPGPKGPPGHQGKDGRPGHPGQRGELGFQGQTGPPGPAGVLGPQGKTGEVGPLGE 933

Query: 573  MEGPNVPNPASRPGLSGVSWPDDV-----PKIPDGRNFPPGQGIFSGPGRGERFPNPQGL 627
               P  P P    GL G+   +       P  P G+  P G   F GP  G   P P GL
Sbjct: 934  RGPPGPPGPPGEQGLPGLEGREGAKGELGPPGPLGKEGPAGLRGFPGPKGGPGDPGPTGL 993

Query: 628  SEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFP-RIPVEGPL 686
              +             PPG    G   S       PG +  + P      P +   EGP+
Sbjct: 994  KGDKG-----------PPGPV--GANGS-------PGERGPLGPAGGIGLPGQSGSEGPV 1033

Query: 687  SP-----SRGDF-------PKGIPPQMGP-GRELEFGMVPSGM---KGDVNLNVNMGSNS 730
             P     SRG+          GIP  +GP G     G  PSG    KGDV    + GS  
Sbjct: 1034 GPAGKKGSRGERGPPGPTGKDGIPGPLGPLGPPGAAG--PSGEEGDKGDVGAPGHKGSKG 1091

Query: 731  QMIPQKMREAGAGPEEMLKLR-------PGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRP 783
                    +  AGP     +R       P G+D    ++    L FG+        G R 
Sbjct: 1092 D-------KGDAGPPGQPGIRGPAGHPGPPGADGAQGRRGPPGL-FGQKGDD----GVRG 1139

Query: 784  FLPMSQGPGSNSGLRNLREPIGPDQRTN---SRLSHMPPLPLNPSSNPTSLNTAPPVQRG 840
            F+ +   PG    L+ L  P G         S   H  P P  P   PT     P +  G
Sbjct: 1140 FVGVIGPPG----LQGLPGPPGEKGEVGDVGSMGPHGAPGPRGPQG-PTGSEGTPGLPGG 1194

Query: 841  LGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNL--KSPQTPSQLAGMLAG 898
            +G+ P  +   G +  +    P  +P         +  P G++  K    PS       G
Sbjct: 1195 VGQ-PGAVGEKGERGDAGDPGPPGAPG--------IPGPKGDIGEKGDSGPS-------G 1238

Query: 899  PAAAASIKSPPVLGSAAAS------PVHLKSPSLPAPS-----------PGWTSSPKPPL 941
             A     K PP    A  S      P  L  P  P  S           PG    P PP 
Sbjct: 1239 AAGPPGKKGPPGEDGAKGSVGPTGLPGDLGPPGDPGVSGIDGSPGEKGDPGDVGGPGPPG 1298

Query: 942  QS--PGIP--PNHKAPLTMAS-------------------PAMLGNVESGGPPPPTASQ- 977
             S  PG P  P  + P                        P   G + + GPP     + 
Sbjct: 1299 ASGEPGAPGPPGKRGPSGHMGREGREGEKGAKGEPGPDGPPGRTGPMGARGPPGRVGPEG 1358

Query: 978  ----PASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVA 1033
                P  V  PG L    P  M P   L  + L  +                H  +  + 
Sbjct: 1359 LRGIPGPVGEPGLL--GAPGQMGPPGPLGPSGLPGLKGDTGPKGEKG-----HIGLIGLI 1411

Query: 1034 SSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLS---PMGMTQPLSHSN 1090
                ++       LP +   PG       P+   P P  P+ +L    P G+  PL    
Sbjct: 1412 GPPGEAGEKGDQGLPGVQGPPG-------PK-GDPGPPGPIGSLGHPGPPGVAGPLGQKG 1463

Query: 1091 QMPSPNAVGP--NIPPHGVPMGPG 1112
               SP ++GP  +  P G P  PG
Sbjct: 1464 SKGSPGSMGPRGDTGPAGPPGPPG 1487



 Score = 34.7 bits (78), Expect = 0.67
 Identities = 33/148 (22%), Positives = 49/148 (33%), Gaps = 16/148 (10%)

Query: 12  PSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGH 71
           P G T  + +     ++ P     P+G P +       G +G      +P P   + G H
Sbjct: 588 PPGPTGQAGEPGPRGLLGPRGSPGPTGRPGVTGIDGAPGAKGNVGPPGEPGP-PGQQGNH 646

Query: 72  TPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDIKECNSADHI 131
             + LPGP G +G       G KG             +   PG P  D  +         
Sbjct: 647 GSQGLPGPQGLIGTP-----GEKG----------PPGNPGIPGLPGSDGPLGHPGHEGPT 691

Query: 132 KSQDSQHTPHSMTPSNATAPRSSTPSHG 159
             + +Q  P S  P     PR    + G
Sbjct: 692 GEKGAQGPPGSAGPPGYPGPRGVKGTSG 719


>gi|32895368 alpha 1 type VIII collagen precursor [Homo sapiens]
          Length = 744

 Score =  102 bits (255), Expect = 2e-21
 Identities = 124/412 (30%), Positives = 160/412 (38%), Gaps = 82/412 (19%)

Query: 1040 PPARSPNLPSMNNMPG-MGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAV 1098
            P    P +P M   PG MG+      I     + PM    P G           P P+  
Sbjct: 155  PGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGP----------PGPHG- 203

Query: 1099 GPNIPPHGVPMGPGLMSH-NPIMGHGSQEPP-----MVPQGRMGFPQ-GFPPVQSPPQQV 1151
               +P  G P GPGL     P    G +  P       P+G  GF   G P V+ PP   
Sbjct: 204  ---LPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGMH 260

Query: 1152 PFPHNGPSGGQG-SFPGGMGFPG-EGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGN 1209
              P  GP G  G   PG  GFPG +GPLG               KPG PG P     +G 
Sbjct: 261  GPP--GPVGLPGVGKPGVTGFPGPQGPLG---------------KPGAPGEPGPQGPIG- 302

Query: 1210 SMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGE-VPGRKQPQGPGP 1268
             +P V   P +  + +PG  GIP        P  K  Q L   P    +PG  +P  PGP
Sbjct: 303  -VPGVQGPPGIPGIGKPGQDGIPG---QPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGP 358

Query: 1269 ----GFSHMQGMMGEQAPRMGLALPGMGGP-GPVGTPDIPLGTAPSMPGHNPMRPPAFLQ 1323
                G   + G +G +  +  +  PG+GGP G  G P IP           PM PP  + 
Sbjct: 359  KGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIP----------GPMGPPGAI- 407

Query: 1324 QGMMGPHHR--MMSPAQSTMP-GQPTLMSNPAAAVGMIPG--KDRGPAGLYTHPGPVGSP 1378
             G  GP     ++ P     P G+P L   P       PG   + GP G+   PGP+G  
Sbjct: 408  -GFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGK-----PGFLGEVGPPGMRGLPGPIGPK 461

Query: 1379 GM--------MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            G         +  + G++GP+    IP     +G     G+GG S   G PG
Sbjct: 462  GEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPG 513



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 155/595 (26%), Positives = 201/595 (33%), Gaps = 124/595 (20%)

Query: 868  MHQVQ-SPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSL 926
            M ++Q +P +G  +   K  + P        GP      + PP              P L
Sbjct: 90   MKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPP------------GPPGL 137

Query: 927  PAPS-PGWTSSPKPP----LQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTA-----S 976
            P    PG    P P     +  PG+P     P  M  P   G +   G   P        
Sbjct: 138  PGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQG 197

Query: 977  QPASVNIPG-SLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASS 1035
             P    +PG   P        P P   + P  +          P    L           
Sbjct: 198  PPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGL----------PGPQGL----------- 236

Query: 1036 DDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSP 1095
                   R P       MPG       P + GP   V +P +   G+T        +  P
Sbjct: 237  -------RGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKP 289

Query: 1096 NAVGPNIP--PHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFP-----QGFPPVQSPP 1148
             A G   P  P GVP   G+     I G G      +P G+ GFP     QG P +  PP
Sbjct: 290  GAPGEPGPQGPIGVP---GVQGPPGIPGIGKPGQDGIP-GQPGFPGGKGEQGLPGLPGPP 345

Query: 1149 Q-----QVPFPHNGPSG--GQGSFPGGMGFPGE-GPLGRPS--NLPQSSADAALCKPGGP 1198
                  +  FP  GP G  G G  PG +G  GE GP+G P     P       +  P GP
Sbjct: 346  GLPGIGKPGFP--GPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGP 403

Query: 1199 GGPDSFT-------VLG-NSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQ 1250
             G   F        ++G    P    +P LQ     G  G P F L  + P         
Sbjct: 404  PGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQ-----GFPGKPGF-LGEVGPPGMRGLPGP 457

Query: 1251 YFPRGEVPGRKQPQGPG-PGFSHMQG---MMGEQAPRMGLALPGMGGP-GPVGTPDIPLG 1305
              P+GE   +  P  PG PG    +G   + G+Q  +    +PG+GGP GP+G P IP  
Sbjct: 458  IGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGP 517

Query: 1306 TA-PSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRG 1364
               P +PG  P   P   + G+ G H           PG+P        A+G      +G
Sbjct: 518  KGEPGLPG--PPGFPGIGKPGVAGLHGP---------PGKP-------GALG-----PQG 554

Query: 1365 PAGLYTHPGPVGSPGMMMSM------QGMMGPQQNIMIPPQMRPRGMAADVGMGG 1413
              GL   PGP G PG    M      QG   P   + I     P    A  G  G
Sbjct: 555  QPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNG 609



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 119/452 (26%), Positives = 145/452 (32%), Gaps = 101/452 (22%)

Query: 533 PFSDGINMPHSLPPRGMAPHPNMPG--------SQMRLPGFAGMINSEMEG----PNVPN 580
           P   G   PH LP  G    P +PG            LPG  G+   + +     P  P 
Sbjct: 193 PGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPG 252

Query: 581 PASRPGLSGVSWPDDVPKI--PDGRNFPPGQGIFSGPGR-GERFPNPQG-LSEEMFQ--- 633
               PG+ G   P  +P +  P    FP  QG    PG  GE  P PQG +     Q   
Sbjct: 253 VKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGE--PGPQGPIGVPGVQGPP 310

Query: 634 ---------QQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEG 684
                    Q     Q G P G   +G+ P +     +PG  +   PG         V G
Sbjct: 311 GIPGIGKPGQDGIPGQPGFPGGKGEQGL-PGLPGPPGLPGIGKPGFPGPKGDRGMGGVPG 369

Query: 685 PLSPSRGDFPKGIPPQMGPGRELEFGMVPS--GMKGDVNLNVNMGSNSQMIPQKMREAGA 742
            L P     P G P   GP  E     +P   G  G +      G    + PQ       
Sbjct: 370 ALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQ------- 422

Query: 743 GPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLRE 802
           GP       PG                   P+ E G+   P  P   G     G+R L  
Sbjct: 423 GP-------PG-------------------PKGEPGLQGFPGKPGFLGEVGPPGMRGLPG 456

Query: 803 PIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINP 862
           PIGP      +   +P LP  P          P  + G+   P D  + G     PGI  
Sbjct: 457 PIGPKGEAGQK--GVPGLPGVPGL------LGPKGEPGI---PGDQGLQG----PPGI-- 499

Query: 863 LKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGM-LAGPAAAASIKSPPVLG--SAAASPV 919
                      P +G PSG +  P  P       L GP     I  P V G       P 
Sbjct: 500 -----------PGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPG 548

Query: 920 HL---KSPSLPAPSPGWTSSPKPPLQSPGIPP 948
            L     P LP P PG    P PP   P  PP
Sbjct: 549 ALGPQGQPGLPGP-PGPPGPPGPPAVMPPTPP 579



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 153/633 (24%), Positives = 200/633 (31%), Gaps = 130/633 (20%)

Query: 615  PGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNN 674
            P    + P  Q L +++    LA+   GL  G  M  ++   E   + P   + ++P   
Sbjct: 42   PQMPPQIPQYQPLGQQVPHMPLAKD--GLAMGKEMPHLQYGKEYPHL-PQYMKEIQPAPR 98

Query: 675  PIFPRIPVEG---PLSPSRGDF-PKGIP-PQMGPGRELEFGMVPSGMKGDVNLNVNMGSN 729
                 +P +G   PL+  RG+  P+G P P+  PG     G    G+KG        G  
Sbjct: 99   MGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVG 158

Query: 730  SQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPL-------PFGEHPQQEYGMGPR 782
               +P    + GA         PG    +  + ++ P+       P G H     G    
Sbjct: 159  KPGMPGMPGKPGAMG------MPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGG 212

Query: 783  PFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLG 842
            P LP   GP  + G + L  P G       +   MP  P             PP   G+ 
Sbjct: 213  PGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKG---------PP---GMH 260

Query: 843  RKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSG-NLKSPQTPSQLAGMLAGPAA 901
              P  + + G  V  PG+     P     Q P LG P       PQ P  + G+  GP  
Sbjct: 261  GPPGPVGLPG--VGKPGVTGFPGP-----QGP-LGKPGAPGEPGPQGPIGVPGV-QGPPG 311

Query: 902  AASIKSP-----PVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSP------GIPPNH 950
               I  P     P              P LP P PG     KP    P      G  P  
Sbjct: 312  IPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGP-PGLPGIGKPGFPGPKGDRGMGGVPGA 370

Query: 951  KAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMM 1010
              P     P  +G    GGPP     +P    IPG +        PP       P     
Sbjct: 371  LGPRGEKGP--IGAPGIGGPP----GEPGLPGIPGPMG-------PPGAIGFPGPKG--- 414

Query: 1011 SRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISG-PN 1069
                    P   P                 P   P L      PG       P + G P 
Sbjct: 415  --EGGIVGPQGPP----------------GPKGEPGLQGFPGKPGFLGEVGPPGMRGLPG 456

Query: 1070 PVVPMPTLSPMGMTQPLSHSNQMPS-PNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPP 1128
            P+ P       G+         +P  P  +GP   P G+P   GL     I G G     
Sbjct: 457  PIGPKGEAGQKGVPG-------LPGVPGLLGPKGEP-GIPGDQGLQGPPGIPGIGG---- 504

Query: 1129 MVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPG---------EGPLGR 1179
              P G +G P G P              GP G  G  PG  GFPG          GP G+
Sbjct: 505  --PSGPIG-PPGIP--------------GPKGEPG-LPGPPGFPGIGKPGVAGLHGPPGK 546

Query: 1180 PSNLPQSSADAALCKPGGPGGPDSFTVLGNSMP 1212
            P  L           PG PG P    V+  + P
Sbjct: 547  PGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPP 579



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 104/420 (24%), Positives = 139/420 (33%), Gaps = 75/420 (17%)

Query: 233 PLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSP 292
           P PQ PP P              P  P P     P   P P     P  +       G P
Sbjct: 193 PGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDK----GFGMP 248

Query: 293 -ASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGL 351
            A     PP   GP   P    +  V +   +    P+ P   P + GEP   G  P G+
Sbjct: 249 GAPGVKGPPGMHGP---PGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQG--PIGV 303

Query: 352 SQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMA 411
              Q       +  +    +   P +  F G +  G Q  PG L GP   P         
Sbjct: 304 PGVQ---GPPGIPGIGKPGQDGIPGQPGFPGGK--GEQGLPG-LPGPPGLPGIGKPGFPG 357

Query: 412 QSQSLGKGP-----GPRTD---VGAPF--GPQGHRDVPFSPDEMVPPSM------NSQSG 455
                G G      GPR +   +GAP   GP G   +P  P  M PP          + G
Sbjct: 358 PKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGG 417

Query: 456 TIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPP 515
            +GP                     +     + +  +Q    +   + + GP G+ RG P
Sbjct: 418 IVGP---------------------QGPPGPKGEPGLQGFPGKPGFLGEVGPPGM-RGLP 455

Query: 516 PPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQ-----MRLPGFAGMIN 570
            P      +G A     P   G+  P  L P+G    P +PG Q       +PG  G  +
Sbjct: 456 GPIG---PKGEAGQKGVPGLPGV--PGLLGPKG---EPGIPGDQGLQGPPGIPGIGGP-S 506

Query: 571 SEMEGPNVPNPASRPGLSGVSWPDDVPKIPD----GRNFPPGQGIFSGPGRGERFPNPQG 626
             +  P +P P   PGL G   P   P I      G + PPG+    GP      P P G
Sbjct: 507 GPIGPPGIPGPKGEPGLPG---PPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPG 563



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 103/404 (25%), Positives = 133/404 (32%), Gaps = 96/404 (23%)

Query: 238 PPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRES---PGVENKL-IPSVGSPA 293
           PP P              P P    P  KP AP  P  +     PGV+    IP +G P 
Sbjct: 262 PPGPVGLPGVGKPGVTGFPGPQ--GPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKP- 318

Query: 294 SSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSS-GEPPTLGENPDGLS 352
                     G +  P      P   G       P  P PP +   G+P   G   D   
Sbjct: 319 ----------GQDGIPGQ----PGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGD--- 361

Query: 353 QEQLEHRERSLQTLRDIQRMLFP-DEKEFTGAQS-GGPQQNPGV--LDGPQKKPEGPIQA 408
                      + +  +   L P  EK   GA   GGP   PG+  + GP   P G I  
Sbjct: 362 -----------RGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPP-GAIGF 409

Query: 409 MMAQSQSLGKGP-GPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTP 467
              + +    GP GP    G P G QG    P    E+ PP M    G IGP        
Sbjct: 410 PGPKGEGGIVGPQGPPGPKGEP-GLQGFPGKPGFLGEVGPPGMRGLPGPIGP-------- 460

Query: 468 EQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGV--------VRGPPPPYQ 519
                          K    ++ V     +  ++    GP+G         ++GPP    
Sbjct: 461 ---------------KGEAGQKGVPGLPGVPGLL----GPKGEPGIPGDQGLQGPPG--- 498

Query: 520 MTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVP 579
             P  G   G   P   GI  P   P  G+   P  PG  +  PG AG ++     P   
Sbjct: 499 -IPGIGGPSGPIGP--PGIPGPKGEP--GLPGPPGFPG--IGKPGVAG-LHGPPGKPGAL 550

Query: 580 NPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPN 623
            P  +PGL G       P  P G   PP     + P +GE  P+
Sbjct: 551 GPQGQPGLPG-------PPGPPGPPGPPAVMPPTPPPQGEYLPD 587



 Score = 36.6 bits (83), Expect = 0.18
 Identities = 25/72 (34%), Positives = 28/72 (38%), Gaps = 5/72 (6%)

Query: 24  QEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSM 83
           Q+  + P  +  P G P         GK GG     QP P     G   PK LPGP G  
Sbjct: 183 QKGEIGPMGIPGPQGPPGPHG-LPGIGKPGGPGLPGQPGP----KGDRGPKGLPGPQGLR 237

Query: 84  GLKNGAGNGAKG 95
           G K   G G  G
Sbjct: 238 GPKGDKGFGMPG 249



 Score = 32.0 bits (71), Expect = 4.4
 Identities = 27/95 (28%), Positives = 33/95 (34%), Gaps = 12/95 (12%)

Query: 258 PPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPV 317
           P IP P  +P  P  P     PG+    +  +  P    P  P   GP   P      P 
Sbjct: 512 PGIPGPKGEPGLPGPP---GFPGIGKPGVAGLHGP----PGKPGALGPQGQPG----LPG 560

Query: 318 SQGSNSSSADPKAPPPPPVSSGE-PPTLGENPDGL 351
             G       P   PP P   GE  P +G   DG+
Sbjct: 561 PPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGV 595


>gi|17738302 alpha 1 type VIII collagen precursor [Homo sapiens]
          Length = 744

 Score =  102 bits (255), Expect = 2e-21
 Identities = 124/412 (30%), Positives = 160/412 (38%), Gaps = 82/412 (19%)

Query: 1040 PPARSPNLPSMNNMPG-MGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAV 1098
            P    P +P M   PG MG+      I     + PM    P G           P P+  
Sbjct: 155  PGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGP----------PGPHG- 203

Query: 1099 GPNIPPHGVPMGPGLMSH-NPIMGHGSQEPP-----MVPQGRMGFPQ-GFPPVQSPPQQV 1151
               +P  G P GPGL     P    G +  P       P+G  GF   G P V+ PP   
Sbjct: 204  ---LPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGMH 260

Query: 1152 PFPHNGPSGGQG-SFPGGMGFPG-EGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGN 1209
              P  GP G  G   PG  GFPG +GPLG               KPG PG P     +G 
Sbjct: 261  GPP--GPVGLPGVGKPGVTGFPGPQGPLG---------------KPGAPGEPGPQGPIG- 302

Query: 1210 SMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGE-VPGRKQPQGPGP 1268
             +P V   P +  + +PG  GIP        P  K  Q L   P    +PG  +P  PGP
Sbjct: 303  -VPGVQGPPGIPGIGKPGQDGIPG---QPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGP 358

Query: 1269 ----GFSHMQGMMGEQAPRMGLALPGMGGP-GPVGTPDIPLGTAPSMPGHNPMRPPAFLQ 1323
                G   + G +G +  +  +  PG+GGP G  G P IP           PM PP  + 
Sbjct: 359  KGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIP----------GPMGPPGAI- 407

Query: 1324 QGMMGPHHR--MMSPAQSTMP-GQPTLMSNPAAAVGMIPG--KDRGPAGLYTHPGPVGSP 1378
             G  GP     ++ P     P G+P L   P       PG   + GP G+   PGP+G  
Sbjct: 408  -GFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGK-----PGFLGEVGPPGMRGLPGPIGPK 461

Query: 1379 GM--------MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            G         +  + G++GP+    IP     +G     G+GG S   G PG
Sbjct: 462  GEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPG 513



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 155/595 (26%), Positives = 201/595 (33%), Gaps = 124/595 (20%)

Query: 868  MHQVQ-SPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSL 926
            M ++Q +P +G  +   K  + P        GP      + PP              P L
Sbjct: 90   MKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPP------------GPPGL 137

Query: 927  PAPS-PGWTSSPKPP----LQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTA-----S 976
            P    PG    P P     +  PG+P     P  M  P   G +   G   P        
Sbjct: 138  PGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQG 197

Query: 977  QPASVNIPG-SLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASS 1035
             P    +PG   P        P P   + P  +          P    L           
Sbjct: 198  PPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGL----------PGPQGL----------- 236

Query: 1036 DDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSP 1095
                   R P       MPG       P + GP   V +P +   G+T        +  P
Sbjct: 237  -------RGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKP 289

Query: 1096 NAVGPNIP--PHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFP-----QGFPPVQSPP 1148
             A G   P  P GVP   G+     I G G      +P G+ GFP     QG P +  PP
Sbjct: 290  GAPGEPGPQGPIGVP---GVQGPPGIPGIGKPGQDGIP-GQPGFPGGKGEQGLPGLPGPP 345

Query: 1149 Q-----QVPFPHNGPSG--GQGSFPGGMGFPGE-GPLGRPS--NLPQSSADAALCKPGGP 1198
                  +  FP  GP G  G G  PG +G  GE GP+G P     P       +  P GP
Sbjct: 346  GLPGIGKPGFP--GPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGP 403

Query: 1199 GGPDSFT-------VLG-NSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQ 1250
             G   F        ++G    P    +P LQ     G  G P F L  + P         
Sbjct: 404  PGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQ-----GFPGKPGF-LGEVGPPGMRGLPGP 457

Query: 1251 YFPRGEVPGRKQPQGPG-PGFSHMQG---MMGEQAPRMGLALPGMGGP-GPVGTPDIPLG 1305
              P+GE   +  P  PG PG    +G   + G+Q  +    +PG+GGP GP+G P IP  
Sbjct: 458  IGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGP 517

Query: 1306 TA-PSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRG 1364
               P +PG  P   P   + G+ G H           PG+P        A+G      +G
Sbjct: 518  KGEPGLPG--PPGFPGIGKPGVAGLHGP---------PGKP-------GALG-----PQG 554

Query: 1365 PAGLYTHPGPVGSPGMMMSM------QGMMGPQQNIMIPPQMRPRGMAADVGMGG 1413
              GL   PGP G PG    M      QG   P   + I     P    A  G  G
Sbjct: 555  QPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNG 609



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 119/452 (26%), Positives = 145/452 (32%), Gaps = 101/452 (22%)

Query: 533 PFSDGINMPHSLPPRGMAPHPNMPG--------SQMRLPGFAGMINSEMEG----PNVPN 580
           P   G   PH LP  G    P +PG            LPG  G+   + +     P  P 
Sbjct: 193 PGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPG 252

Query: 581 PASRPGLSGVSWPDDVPKI--PDGRNFPPGQGIFSGPGR-GERFPNPQG-LSEEMFQ--- 633
               PG+ G   P  +P +  P    FP  QG    PG  GE  P PQG +     Q   
Sbjct: 253 VKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGE--PGPQGPIGVPGVQGPP 310

Query: 634 ---------QQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEG 684
                    Q     Q G P G   +G+ P +     +PG  +   PG         V G
Sbjct: 311 GIPGIGKPGQDGIPGQPGFPGGKGEQGL-PGLPGPPGLPGIGKPGFPGPKGDRGMGGVPG 369

Query: 685 PLSPSRGDFPKGIPPQMGPGRELEFGMVPS--GMKGDVNLNVNMGSNSQMIPQKMREAGA 742
            L P     P G P   GP  E     +P   G  G +      G    + PQ       
Sbjct: 370 ALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQ------- 422

Query: 743 GPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLRE 802
           GP       PG                   P+ E G+   P  P   G     G+R L  
Sbjct: 423 GP-------PG-------------------PKGEPGLQGFPGKPGFLGEVGPPGMRGLPG 456

Query: 803 PIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINP 862
           PIGP      +   +P LP  P          P  + G+   P D  + G     PGI  
Sbjct: 457 PIGPKGEAGQK--GVPGLPGVPGL------LGPKGEPGI---PGDQGLQG----PPGI-- 499

Query: 863 LKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGM-LAGPAAAASIKSPPVLG--SAAASPV 919
                      P +G PSG +  P  P       L GP     I  P V G       P 
Sbjct: 500 -----------PGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPG 548

Query: 920 HL---KSPSLPAPSPGWTSSPKPPLQSPGIPP 948
            L     P LP P PG    P PP   P  PP
Sbjct: 549 ALGPQGQPGLPGP-PGPPGPPGPPAVMPPTPP 579



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 153/633 (24%), Positives = 200/633 (31%), Gaps = 130/633 (20%)

Query: 615  PGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNN 674
            P    + P  Q L +++    LA+   GL  G  M  ++   E   + P   + ++P   
Sbjct: 42   PQMPPQIPQYQPLGQQVPHMPLAKD--GLAMGKEMPHLQYGKEYPHL-PQYMKEIQPAPR 98

Query: 675  PIFPRIPVEG---PLSPSRGDF-PKGIP-PQMGPGRELEFGMVPSGMKGDVNLNVNMGSN 729
                 +P +G   PL+  RG+  P+G P P+  PG     G    G+KG        G  
Sbjct: 99   MGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVG 158

Query: 730  SQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPL-------PFGEHPQQEYGMGPR 782
               +P    + GA         PG    +  + ++ P+       P G H     G    
Sbjct: 159  KPGMPGMPGKPGAMG------MPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGG 212

Query: 783  PFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLG 842
            P LP   GP  + G + L  P G       +   MP  P             PP   G+ 
Sbjct: 213  PGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKG---------PP---GMH 260

Query: 843  RKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSG-NLKSPQTPSQLAGMLAGPAA 901
              P  + + G  V  PG+     P     Q P LG P       PQ P  + G+  GP  
Sbjct: 261  GPPGPVGLPG--VGKPGVTGFPGP-----QGP-LGKPGAPGEPGPQGPIGVPGV-QGPPG 311

Query: 902  AASIKSP-----PVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSP------GIPPNH 950
               I  P     P              P LP P PG     KP    P      G  P  
Sbjct: 312  IPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGP-PGLPGIGKPGFPGPKGDRGMGGVPGA 370

Query: 951  KAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMM 1010
              P     P  +G    GGPP     +P    IPG +        PP       P     
Sbjct: 371  LGPRGEKGP--IGAPGIGGPP----GEPGLPGIPGPMG-------PPGAIGFPGPKG--- 414

Query: 1011 SRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISG-PN 1069
                    P   P                 P   P L      PG       P + G P 
Sbjct: 415  --EGGIVGPQGPP----------------GPKGEPGLQGFPGKPGFLGEVGPPGMRGLPG 456

Query: 1070 PVVPMPTLSPMGMTQPLSHSNQMPS-PNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPP 1128
            P+ P       G+         +P  P  +GP   P G+P   GL     I G G     
Sbjct: 457  PIGPKGEAGQKGVPG-------LPGVPGLLGPKGEP-GIPGDQGLQGPPGIPGIGG---- 504

Query: 1129 MVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPG---------EGPLGR 1179
              P G +G P G P              GP G  G  PG  GFPG          GP G+
Sbjct: 505  --PSGPIG-PPGIP--------------GPKGEPG-LPGPPGFPGIGKPGVAGLHGPPGK 546

Query: 1180 PSNLPQSSADAALCKPGGPGGPDSFTVLGNSMP 1212
            P  L           PG PG P    V+  + P
Sbjct: 547  PGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPP 579



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 104/420 (24%), Positives = 139/420 (33%), Gaps = 75/420 (17%)

Query: 233 PLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSP 292
           P PQ PP P              P  P P     P   P P     P  +       G P
Sbjct: 193 PGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDK----GFGMP 248

Query: 293 -ASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGL 351
            A     PP   GP   P    +  V +   +    P+ P   P + GEP   G  P G+
Sbjct: 249 GAPGVKGPPGMHGP---PGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQG--PIGV 303

Query: 352 SQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMA 411
              Q       +  +    +   P +  F G +  G Q  PG L GP   P         
Sbjct: 304 PGVQ---GPPGIPGIGKPGQDGIPGQPGFPGGK--GEQGLPG-LPGPPGLPGIGKPGFPG 357

Query: 412 QSQSLGKGP-----GPRTD---VGAPF--GPQGHRDVPFSPDEMVPPSM------NSQSG 455
                G G      GPR +   +GAP   GP G   +P  P  M PP          + G
Sbjct: 358 PKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGG 417

Query: 456 TIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPP 515
            +GP                     +     + +  +Q    +   + + GP G+ RG P
Sbjct: 418 IVGP---------------------QGPPGPKGEPGLQGFPGKPGFLGEVGPPGM-RGLP 455

Query: 516 PPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQ-----MRLPGFAGMIN 570
            P      +G A     P   G+  P  L P+G    P +PG Q       +PG  G  +
Sbjct: 456 GPIG---PKGEAGQKGVPGLPGV--PGLLGPKG---EPGIPGDQGLQGPPGIPGIGGP-S 506

Query: 571 SEMEGPNVPNPASRPGLSGVSWPDDVPKIPD----GRNFPPGQGIFSGPGRGERFPNPQG 626
             +  P +P P   PGL G   P   P I      G + PPG+    GP      P P G
Sbjct: 507 GPIGPPGIPGPKGEPGLPG---PPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPG 563



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 103/404 (25%), Positives = 133/404 (32%), Gaps = 96/404 (23%)

Query: 238 PPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRES---PGVENKL-IPSVGSPA 293
           PP P              P P    P  KP AP  P  +     PGV+    IP +G P 
Sbjct: 262 PPGPVGLPGVGKPGVTGFPGPQ--GPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKP- 318

Query: 294 SSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSS-GEPPTLGENPDGLS 352
                     G +  P      P   G       P  P PP +   G+P   G   D   
Sbjct: 319 ----------GQDGIPGQ----PGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGD--- 361

Query: 353 QEQLEHRERSLQTLRDIQRMLFP-DEKEFTGAQS-GGPQQNPGV--LDGPQKKPEGPIQA 408
                      + +  +   L P  EK   GA   GGP   PG+  + GP   P G I  
Sbjct: 362 -----------RGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPP-GAIGF 409

Query: 409 MMAQSQSLGKGP-GPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTP 467
              + +    GP GP    G P G QG    P    E+ PP M    G IGP        
Sbjct: 410 PGPKGEGGIVGPQGPPGPKGEP-GLQGFPGKPGFLGEVGPPGMRGLPGPIGP-------- 460

Query: 468 EQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGV--------VRGPPPPYQ 519
                          K    ++ V     +  ++    GP+G         ++GPP    
Sbjct: 461 ---------------KGEAGQKGVPGLPGVPGLL----GPKGEPGIPGDQGLQGPPG--- 498

Query: 520 MTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVP 579
             P  G   G   P   GI  P   P  G+   P  PG  +  PG AG ++     P   
Sbjct: 499 -IPGIGGPSGPIGP--PGIPGPKGEP--GLPGPPGFPG--IGKPGVAG-LHGPPGKPGAL 550

Query: 580 NPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPN 623
            P  +PGL G       P  P G   PP     + P +GE  P+
Sbjct: 551 GPQGQPGLPG-------PPGPPGPPGPPAVMPPTPPPQGEYLPD 587



 Score = 36.6 bits (83), Expect = 0.18
 Identities = 25/72 (34%), Positives = 28/72 (38%), Gaps = 5/72 (6%)

Query: 24  QEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSM 83
           Q+  + P  +  P G P         GK GG     QP P     G   PK LPGP G  
Sbjct: 183 QKGEIGPMGIPGPQGPPGPHG-LPGIGKPGGPGLPGQPGP----KGDRGPKGLPGPQGLR 237

Query: 84  GLKNGAGNGAKG 95
           G K   G G  G
Sbjct: 238 GPKGDKGFGMPG 249



 Score = 32.0 bits (71), Expect = 4.4
 Identities = 27/95 (28%), Positives = 33/95 (34%), Gaps = 12/95 (12%)

Query: 258 PPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPV 317
           P IP P  +P  P  P     PG+    +  +  P    P  P   GP   P      P 
Sbjct: 512 PGIPGPKGEPGLPGPP---GFPGIGKPGVAGLHGP----PGKPGALGPQGQPG----LPG 560

Query: 318 SQGSNSSSADPKAPPPPPVSSGE-PPTLGENPDGL 351
             G       P   PP P   GE  P +G   DG+
Sbjct: 561 PPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGV 595


>gi|148536823 type IV alpha 6 collagen isoform A precursor [Homo
            sapiens]
          Length = 1691

 Score =  101 bits (252), Expect = 4e-21
 Identities = 333/1366 (24%), Positives = 460/1366 (33%), Gaps = 282/1366 (20%)

Query: 235  PQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPL-DRESPGVENKLIPSVGSPA 293
            P  PP P   D N     + +         P PA PP    + E  G       S G P 
Sbjct: 206  PPGPPGPLGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPG 265

Query: 294  SSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPP-----------PPVSSGEPP 342
                  P  +GP   P     T   +G       P  P P           PP   G+  
Sbjct: 266  PKGF--PGISGPPGFPG--LGTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKG 321

Query: 343  TLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEK-EFTGAQSGGPQQNPGVLDGPQKK 401
            TLG    GL+  Q       ++  +    +  PD   +  GA   G   +PGV   P  K
Sbjct: 322  TLGF--PGLNGFQ------GIEGQKGDIGLPGPDVFIDIDGAVISGNPGDPGVPGLPGLK 373

Query: 402  PEGPIQAMMAQSQSLG----------------------KGPGPRTDVGAPFGPQGHRDVP 439
             +  IQ +   S   G                      +G   RT +GA  G  G   +P
Sbjct: 374  GDEGIQGLRGPSGVPGLPALSGVPGALGPQGFPGLKGDQGNPGRTTIGAA-GLPGRDGLP 432

Query: 440  FSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQD 499
              P    PPS   ++ T+      H        L+ +Q        K  +     C+  D
Sbjct: 433  GPPGPPGPPSPEFETETL------HNKESGFPGLRGEQGPKGNLGLKGIKGDSGFCAC-D 485

Query: 500  MMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLP----------PRGM 549
              V   GP G   GPP P+ +    G      +  S G   P   P          P+G 
Sbjct: 486  GGVPNTGPPGEP-GPPGPWGLIGLPGLKGARGDRGSGGAQGPAGAPGLVGPLGPSGPKGK 544

Query: 550  APHP------NMPGSQ--MRLPGFAGMINSEMEG--PNVPNPASRPGLSGVSWPDD--VP 597
               P       MPG +      GF G+I    +   P +P     PG  G  +P +  +P
Sbjct: 545  KGEPILSTIQGMPGDRGDSGSQGFRGVIGEPGKDGVPGLPGLPGLPGDGGQGFPGEKGLP 604

Query: 598  KIPDGRNFPPGQGIFSGPGRG-ERFPNPQGLSEEMFQQQLAEKQLGLP--PGMAMEGIRP 654
             +P  +  P   G+   PG G    P P+GL  +  +  L  +Q GLP   G+ +  I P
Sbjct: 605  GLPGEKGHPGPPGL---PGNGLPGLPGPRGLPGDKGKDGLPGQQ-GLPGSKGITLPCIIP 660

Query: 655  SMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGD--------------FP-----K 695
                    PG+     P  +   P  P +   S S+G+              FP     K
Sbjct: 661  GSYGPSGFPGTPGFPGPKGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEK 720

Query: 696  GIPPQMG-PGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPG- 753
            G+P   G PG++   G+   GM G   L  + G+   +      E GA  E+ L+   G 
Sbjct: 721  GLPGFPGLPGKD---GL--PGMIGSPGLPGSKGATGDIFGA---ENGAPGEQGLQGLTGH 772

Query: 754  ----GSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQR 809
                G   LP  + +   P    P+ E G    P      G   +SG   ++   G    
Sbjct: 773  KGFLGDSGLPGLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGA 832

Query: 810  TNSRLSHMPPLPLNPSSNPTSLNTAPP---VQRGL-GRKPLDISVAGSQVHSPGINPLK- 864
                    P +  +P    T     PP   V++GL G K L          +PG+  LK 
Sbjct: 833  PG-----FPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKGLP--------GNPGLVGLKG 879

Query: 865  SPTMHQVQS-PMLGSPSGNLKS------PQTPSQLAGMLAGPAAAASIKSPP----VLGS 913
            SP    V   P L  P G   S      P  P      L G      +K  P     +G 
Sbjct: 880  SPGSPGVAGLPALSGPKGEKGSVGFVGFPGIPG-----LPGIPGTRGLKGIPGSTGKMGP 934

Query: 914  AAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLG----NVESGG 969
            +  +    +      P P    SP+ P+ +  +  +  +  +  S    G      E+G 
Sbjct: 935  SGRAGTPGEKGDRGNPGPVGIPSPRRPMSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGR 994

Query: 970  PPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAI 1029
            P PP    P +  +PG +   +    PP            M       +  S+ +     
Sbjct: 995  PGPP--GLPGAPGLPGIIKGVSGKPGPPG----------FMGIRGLPGLKGSSGI--TGF 1040

Query: 1030 KTVASSDDDSPPARSPNLPSMNNMPGM-GINTQNPRISGPNPVVPMPTLSPMGMTQ---- 1084
              +           SP LP  + +PG+ G N Q   ISG       P  S    T+    
Sbjct: 1041 PGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPGESGFKGTKGRDG 1100

Query: 1085 ---------------PLSHSNQMPSPNAVG-PNIPP-HGVPMGPGLMSHNPIMGHGSQEP 1127
                            +  S  +  P A G P +    G P  PG   H   +G      
Sbjct: 1101 LIGNIGFPGNKGEDGKVGVSGDVGLPGAPGFPGVAGMRGEPGLPGSSGHQGAIGPLGSPG 1160

Query: 1128 PMVPQGRMGFP-----QGFPPVQSPPQQ-------VPFPHN--GPSGGQGSFPG-GMGFP 1172
             + P+G  GFP      G P  +            VP P    GP G +G +PG G+G P
Sbjct: 1161 LIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKG-YPGIGIGAP 1219

Query: 1173 GE-GPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGI 1231
            G+ G  G+  +            PG PG          S+PS+          +PG  G 
Sbjct: 1220 GKPGLRGQKGDRGFPGLQGPAGLPGAPG---------ISLPSLIAG-------QPGDPGR 1263

Query: 1232 PEFDLSRIIPSEK-----PSQTLQYFPRGE-----VPGRKQPQGPG--PGFSHMQGMMGE 1279
            P  D  R  P        P  +      G+     +PG K P+G    PGFS + G +G 
Sbjct: 1264 PGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGDQGIPGFSGLPGELGL 1323

Query: 1280 QAPRMGLALPG-MGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQ 1338
            +  R     PG MG PG VG P  P    P M G    R  + LQ     P     + A 
Sbjct: 1324 KGMR---GEPGFMGTPGKVGPPGDP--GFPGMKGKAGPRGSSGLQGD---PGQTPTAEAV 1375

Query: 1339 STMPGQ---------PTLMSNPAAA--VGM--------IPGKDRGPAGLYTHPGPVGSPG 1379
               PG          P L  +P A   VG+        IPGKD GP+GL   PG +G PG
Sbjct: 1376 QVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKD-GPSGLPGPPGALGDPG 1434

Query: 1380 MMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMM 1425
                + G+ GP      P Q  P GM            PG PG  M
Sbjct: 1435 ----LPGLQGPPGFEGAPGQQGPFGM------------PGMPGQSM 1464



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 113/404 (27%), Positives = 144/404 (35%), Gaps = 88/404 (21%)

Query: 1068 PNPVVPMPTLSPMGMTQPLSHSN---QMPSPNAVGPNIPPHGV-PMG-PGLMSHNPIMGH 1122
            P P+       P G T     S    +   P  +GP  P     PMG PG +  N I GH
Sbjct: 52   PGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIPGH 111

Query: 1123 GSQEPPMVP---------QGRMGF--PQGFPPVQSPPQQVPFPHNGPSGGQ-----GSFP 1166
              Q  P  P         QG +GF  P G+P +  PP     P    S G      GSF 
Sbjct: 112  PGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPP---GLPGQKGSKGDPVLAPGSFK 168

Query: 1167 GGMGFPG----------EGPLGRPSNLPQSSADAALCKPGGPG--GPDSFTVLG-NSMPS 1213
            G  G PG          +G  G P  +  +        PG PG  GPD    LG      
Sbjct: 169  GMKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKG 228

Query: 1214 VFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPG------ 1267
            V  D  L     PG  G P        PS    + +  FP+G+   + +P   G      
Sbjct: 229  VKGDVGL-----PGPAGPP--------PSTGELEFMG-FPKGKKGSKGEPGPKGFPGISG 274

Query: 1268 -PGFSHMQGMMGEQAPRMGLALPGMGGP-GPVGTPDI--PLGT-----APSMPGHNPMRP 1318
             PGF  + G  GE+  +    +PG+ GP GP+G+  +  P G          PG N    
Sbjct: 275  PPGFPGL-GTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGF-- 331

Query: 1319 PAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSP 1378
                 QG+ G            +PG    +    A +   PG D G  GL   PG  G  
Sbjct: 332  -----QGIEG------QKGDIGLPGPDVFIDIDGAVISGNPG-DPGVPGL---PGLKGDE 376

Query: 1379 GMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            G    +QG+ GP     +P      G     G  G     GNPG
Sbjct: 377  G----IQGLRGPSGVPGLPALSGVPGALGPQGFPGLKGDQGNPG 416



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 156/632 (24%), Positives = 198/632 (31%), Gaps = 161/632 (25%)

Query: 918  PVHLKSPSLPAPSPGWTSSPK-------PPLQSPGIPPNHKAPLTMASPAMLG-NVESGG 969
            P+ ++ P+ P    G T           P L  P  P   K P  M  P  LG N   G 
Sbjct: 54   PIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGP--MGVPGFLGINGIPGH 111

Query: 970  PPPPTASQP----------ASVNIPGSLPSSTPYTMPP-----------EPTLSQNPLSI 1008
            P  P    P           +V  PG  P   P  + P           +P L+      
Sbjct: 112  PGQPGPRGPPGLDGCNGTQGAVGFPG--PDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKG 169

Query: 1009 M-----MSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNP 1063
            M     +  +     P   P +  A+          PP     L    NM G+G   +  
Sbjct: 170  MKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNM-GLGFQGEKG 228

Query: 1064 ---RISGPNPVVPMPT---LSPMGMTQPLSHSNQMPSPNAV-GPNIPP------------ 1104
                +  P P  P P+   L  MG  +    S   P P    G + PP            
Sbjct: 229  VKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPKGFPGISGPPGFPGLGTTGEKG 288

Query: 1105 ----HGVPMGPGLMSHNPIMGHGSQEPP--MVPQGRMGFP--QGFPPVQSPPQQVPFPHN 1156
                 G+P  PG     P+   G Q PP     +G +GFP   GF  ++     +  P  
Sbjct: 289  EKGEKGIPGLPG--PRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLP-- 344

Query: 1157 GP-----------SGGQGSFPGGMGFPG----------EGPLGRPSNLPQSSADAALCKP 1195
            GP           SG  G  PG  G PG           GP G P     S    AL   
Sbjct: 345  GPDVFIDIDGAVISGNPGD-PGVPGLPGLKGDEGIQGLRGPSGVPGLPALSGVPGALGPQ 403

Query: 1196 GGPG------GPDSFTVLGNSMPSVFTDPDLQEVIRPGATG--IPEFDLSRIIPSEK--P 1245
            G PG       P   T+    +P     P       PG  G   PEF+   +   E   P
Sbjct: 404  GFPGLKGDQGNPGRTTIGAAGLPGRDGLPG-----PPGPPGPPSPEFETETLHNKESGFP 458

Query: 1246 SQTLQYFPRGE------------------VPGRKQPQGPGP----GFSHMQGMMGEQAPR 1283
                +  P+G                   VP    P  PGP    G   + G+ G +  R
Sbjct: 459  GLRGEQGPKGNLGLKGIKGDSGFCACDGGVPNTGPPGEPGPPGPWGLIGLPGLKGARGDR 518

Query: 1284 MGLALPGMGGP-GPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMS------- 1335
                  G GG  GP G P +     PS P      P     QGM G      S       
Sbjct: 519  ------GSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVI 572

Query: 1336 --PAQSTMPGQPTLMSNPAAAVGMIPGKDRGPA--GLYTHPGPVGSPGMMMSMQGMMGPQ 1391
              P +  +PG P L   P       PG+   P   G   HPGP G PG    + G+ GP 
Sbjct: 573  GEPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGN--GLPGLPGP- 629

Query: 1392 QNIMIPPQMRPRGMAADVGMGGFSQGPGNPGN 1423
                       RG+  D G  G     G PG+
Sbjct: 630  -----------RGLPGDKGKDGLPGQQGLPGS 650



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 75/284 (26%), Positives = 99/284 (34%), Gaps = 67/284 (23%)

Query: 1158 PSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTD 1217
            P GGQ        FP +G  GRP  +             GP GP  FT     +  +  +
Sbjct: 30   PCGGQDCSGSCQCFPEKGARGRPGPIGIQ----------GPTGPQGFTG-STGLSGLKGE 78

Query: 1218 PDLQEVIRP-------GATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGF 1270
                 ++ P       G  G+P F     IP                PG+  P+GP PG 
Sbjct: 79   RGFPGLLGPYGPKGDKGPMGVPGFLGINGIPGH--------------PGQPGPRGP-PGL 123

Query: 1271 SHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPH 1330
                G  G            +G PGP G P + LG  P +PG    +    L  G     
Sbjct: 124  DGCNGTQG-----------AVGFPGPDGYPGL-LG-PPGLPGQKGSKGDPVLAPGSF--- 167

Query: 1331 HRMMSPAQSTMPGQPTL--MSNPAAAVGMIPGK--DRGPAGLYTHPGPVGSPG----MMM 1382
                       PG P L  ++ P  A G  PG     GP GL   PGP G  G    M +
Sbjct: 168  -----KGMKGDPGLPGLDGITGPQGAPG-FPGAVGPAGPPGLQGPPGPPGPLGPDGNMGL 221

Query: 1383 SMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQG----PGNPG 1422
              QG  G + ++ +P    P     ++   GF +G     G PG
Sbjct: 222  GFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPG 265



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 63/236 (26%), Positives = 83/236 (35%), Gaps = 40/236 (16%)

Query: 493 QQCSLQDMMVHQHGPRGV-----VRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPR 547
           Q CS       + G RG      ++GP  P   T S G +    E    G+  P+     
Sbjct: 34  QDCSGSCQCFPEKGARGRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYG---- 89

Query: 548 GMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPP 607
                P      M +PGF G IN     P  P P   PGL G +        P    +P 
Sbjct: 90  -----PKGDKGPMGVPGFLG-INGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYP- 142

Query: 608 GQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQR 667
             G+   PG     P  +G   +            L PG + +G    M+ +  +PG   
Sbjct: 143 --GLLGPPG----LPGQKGSKGDPV----------LAPG-SFKG----MKGDPGLPGLDG 181

Query: 668 HMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMV-PSGMKGDVNL 722
              P   P FP     GP  P     P G P  +GP   +  G     G+KGDV L
Sbjct: 182 ITGPQGAPGFP--GAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKGVKGDVGL 235



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 71/315 (22%), Positives = 105/315 (33%), Gaps = 32/315 (10%)

Query: 529  GGTEPFSDGINMPHSLP-PRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGL 587
            G   P   G+  P  LP P+G   +P +       PG  G    +   P +  PA  PG 
Sbjct: 1187 GTPGPSITGVPGPAGLPGPKGEKGYPGIGIGAPGKPGLRGQ-KGDRGFPGLQGPAGLPGA 1245

Query: 588  SGVSWPDDV---------PKI--------PDGRNFPPGQGIFSGPGRGERFPNPQGLSEE 630
             G+S P  +         P +        P G   PPG     G      FP   G    
Sbjct: 1246 PGISLPSLIAGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGP 1305

Query: 631  MFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSR 690
               Q +     GLP  + ++G+R          G+   + P  +P FP +  +G   P  
Sbjct: 1306 KGDQGIPGFS-GLPGELGLKGMRGEPGFM----GTPGKVGPPGDPGFPGM--KGKAGPRG 1358

Query: 691  GDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKL 750
                +G P Q      ++    P G+ G   +    G      P  ++ +   P    K 
Sbjct: 1359 SSGLQGDPGQTPTAEAVQVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKD 1418

Query: 751  RPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRT 810
             P G    P       LP  + P    G       P  QGP    G+      +G     
Sbjct: 1419 GPSGLPGPPGALGDPGLPGLQGPPGFEGA------PGQQGPFGMPGMPGQSMRVGYTLVK 1472

Query: 811  NSRLSHMPPLPLNPS 825
            +S+   +PP P+  S
Sbjct: 1473 HSQSEQVPPCPIGMS 1487



 Score = 34.3 bits (77), Expect = 0.88
 Identities = 23/66 (34%), Positives = 27/66 (40%), Gaps = 3/66 (4%)

Query: 31   PTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAG 90
            P ++ P G P         G  G   +   P P  S +G   P  LPGP G  G   G G
Sbjct: 1159 PGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGP--SITGVPGPAGLPGPKGEKGYP-GIG 1215

Query: 91   NGAKGK 96
             GA GK
Sbjct: 1216 IGAPGK 1221


>gi|16357503 type IV alpha 6 collagen isoform B precursor [Homo
            sapiens]
          Length = 1690

 Score =  101 bits (252), Expect = 4e-21
 Identities = 333/1366 (24%), Positives = 460/1366 (33%), Gaps = 282/1366 (20%)

Query: 235  PQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPL-DRESPGVENKLIPSVGSPA 293
            P  PP P   D N     + +         P PA PP    + E  G       S G P 
Sbjct: 205  PPGPPGPLGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPG 264

Query: 294  SSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPP-----------PPVSSGEPP 342
                  P  +GP   P     T   +G       P  P P           PP   G+  
Sbjct: 265  PKGF--PGISGPPGFPG--LGTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKG 320

Query: 343  TLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEK-EFTGAQSGGPQQNPGVLDGPQKK 401
            TLG    GL+  Q       ++  +    +  PD   +  GA   G   +PGV   P  K
Sbjct: 321  TLGF--PGLNGFQ------GIEGQKGDIGLPGPDVFIDIDGAVISGNPGDPGVPGLPGLK 372

Query: 402  PEGPIQAMMAQSQSLG----------------------KGPGPRTDVGAPFGPQGHRDVP 439
             +  IQ +   S   G                      +G   RT +GA  G  G   +P
Sbjct: 373  GDEGIQGLRGPSGVPGLPALSGVPGALGPQGFPGLKGDQGNPGRTTIGAA-GLPGRDGLP 431

Query: 440  FSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQD 499
              P    PPS   ++ T+      H        L+ +Q        K  +     C+  D
Sbjct: 432  GPPGPPGPPSPEFETETL------HNKESGFPGLRGEQGPKGNLGLKGIKGDSGFCAC-D 484

Query: 500  MMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLP----------PRGM 549
              V   GP G   GPP P+ +    G      +  S G   P   P          P+G 
Sbjct: 485  GGVPNTGPPGEP-GPPGPWGLIGLPGLKGARGDRGSGGAQGPAGAPGLVGPLGPSGPKGK 543

Query: 550  APHP------NMPGSQ--MRLPGFAGMINSEMEG--PNVPNPASRPGLSGVSWPDD--VP 597
               P       MPG +      GF G+I    +   P +P     PG  G  +P +  +P
Sbjct: 544  KGEPILSTIQGMPGDRGDSGSQGFRGVIGEPGKDGVPGLPGLPGLPGDGGQGFPGEKGLP 603

Query: 598  KIPDGRNFPPGQGIFSGPGRG-ERFPNPQGLSEEMFQQQLAEKQLGLP--PGMAMEGIRP 654
             +P  +  P   G+   PG G    P P+GL  +  +  L  +Q GLP   G+ +  I P
Sbjct: 604  GLPGEKGHPGPPGL---PGNGLPGLPGPRGLPGDKGKDGLPGQQ-GLPGSKGITLPCIIP 659

Query: 655  SMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGD--------------FP-----K 695
                    PG+     P  +   P  P +   S S+G+              FP     K
Sbjct: 660  GSYGPSGFPGTPGFPGPKGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEK 719

Query: 696  GIPPQMG-PGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPG- 753
            G+P   G PG++   G+   GM G   L  + G+   +      E GA  E+ L+   G 
Sbjct: 720  GLPGFPGLPGKD---GL--PGMIGSPGLPGSKGATGDIFGA---ENGAPGEQGLQGLTGH 771

Query: 754  ----GSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQR 809
                G   LP  + +   P    P+ E G    P      G   +SG   ++   G    
Sbjct: 772  KGFLGDSGLPGLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGA 831

Query: 810  TNSRLSHMPPLPLNPSSNPTSLNTAPP---VQRGL-GRKPLDISVAGSQVHSPGINPLK- 864
                    P +  +P    T     PP   V++GL G K L          +PG+  LK 
Sbjct: 832  PG-----FPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKGLP--------GNPGLVGLKG 878

Query: 865  SPTMHQVQS-PMLGSPSGNLKS------PQTPSQLAGMLAGPAAAASIKSPP----VLGS 913
            SP    V   P L  P G   S      P  P      L G      +K  P     +G 
Sbjct: 879  SPGSPGVAGLPALSGPKGEKGSVGFVGFPGIPG-----LPGIPGTRGLKGIPGSTGKMGP 933

Query: 914  AAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLG----NVESGG 969
            +  +    +      P P    SP+ P+ +  +  +  +  +  S    G      E+G 
Sbjct: 934  SGRAGTPGEKGDRGNPGPVGIPSPRRPMSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGR 993

Query: 970  PPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAI 1029
            P PP    P +  +PG +   +    PP            M       +  S+ +     
Sbjct: 994  PGPP--GLPGAPGLPGIIKGVSGKPGPPG----------FMGIRGLPGLKGSSGI--TGF 1039

Query: 1030 KTVASSDDDSPPARSPNLPSMNNMPGM-GINTQNPRISGPNPVVPMPTLSPMGMTQ---- 1084
              +           SP LP  + +PG+ G N Q   ISG       P  S    T+    
Sbjct: 1040 PGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPGESGFKGTKGRDG 1099

Query: 1085 ---------------PLSHSNQMPSPNAVG-PNIPP-HGVPMGPGLMSHNPIMGHGSQEP 1127
                            +  S  +  P A G P +    G P  PG   H   +G      
Sbjct: 1100 LIGNIGFPGNKGEDGKVGVSGDVGLPGAPGFPGVAGMRGEPGLPGSSGHQGAIGPLGSPG 1159

Query: 1128 PMVPQGRMGFP-----QGFPPVQSPPQQ-------VPFPHN--GPSGGQGSFPG-GMGFP 1172
             + P+G  GFP      G P  +            VP P    GP G +G +PG G+G P
Sbjct: 1160 LIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKG-YPGIGIGAP 1218

Query: 1173 GE-GPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGI 1231
            G+ G  G+  +            PG PG          S+PS+          +PG  G 
Sbjct: 1219 GKPGLRGQKGDRGFPGLQGPAGLPGAPG---------ISLPSLIAG-------QPGDPGR 1262

Query: 1232 PEFDLSRIIPSEK-----PSQTLQYFPRGE-----VPGRKQPQGPG--PGFSHMQGMMGE 1279
            P  D  R  P        P  +      G+     +PG K P+G    PGFS + G +G 
Sbjct: 1263 PGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGDQGIPGFSGLPGELGL 1322

Query: 1280 QAPRMGLALPG-MGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQ 1338
            +  R     PG MG PG VG P  P    P M G    R  + LQ     P     + A 
Sbjct: 1323 KGMR---GEPGFMGTPGKVGPPGDP--GFPGMKGKAGPRGSSGLQGD---PGQTPTAEAV 1374

Query: 1339 STMPGQ---------PTLMSNPAAA--VGM--------IPGKDRGPAGLYTHPGPVGSPG 1379
               PG          P L  +P A   VG+        IPGKD GP+GL   PG +G PG
Sbjct: 1375 QVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKD-GPSGLPGPPGALGDPG 1433

Query: 1380 MMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMM 1425
                + G+ GP      P Q  P GM            PG PG  M
Sbjct: 1434 ----LPGLQGPPGFEGAPGQQGPFGM------------PGMPGQSM 1463



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 113/404 (27%), Positives = 144/404 (35%), Gaps = 88/404 (21%)

Query: 1068 PNPVVPMPTLSPMGMTQPLSHSN---QMPSPNAVGPNIPPHGV-PMG-PGLMSHNPIMGH 1122
            P P+       P G T     S    +   P  +GP  P     PMG PG +  N I GH
Sbjct: 51   PGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIPGH 110

Query: 1123 GSQEPPMVP---------QGRMGF--PQGFPPVQSPPQQVPFPHNGPSGGQ-----GSFP 1166
              Q  P  P         QG +GF  P G+P +  PP     P    S G      GSF 
Sbjct: 111  PGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPP---GLPGQKGSKGDPVLAPGSFK 167

Query: 1167 GGMGFPG----------EGPLGRPSNLPQSSADAALCKPGGPG--GPDSFTVLG-NSMPS 1213
            G  G PG          +G  G P  +  +        PG PG  GPD    LG      
Sbjct: 168  GMKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKG 227

Query: 1214 VFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPG------ 1267
            V  D  L     PG  G P        PS    + +  FP+G+   + +P   G      
Sbjct: 228  VKGDVGL-----PGPAGPP--------PSTGELEFMG-FPKGKKGSKGEPGPKGFPGISG 273

Query: 1268 -PGFSHMQGMMGEQAPRMGLALPGMGGP-GPVGTPDI--PLGT-----APSMPGHNPMRP 1318
             PGF  + G  GE+  +    +PG+ GP GP+G+  +  P G          PG N    
Sbjct: 274  PPGFPGL-GTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGF-- 330

Query: 1319 PAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSP 1378
                 QG+ G            +PG    +    A +   PG D G  GL   PG  G  
Sbjct: 331  -----QGIEG------QKGDIGLPGPDVFIDIDGAVISGNPG-DPGVPGL---PGLKGDE 375

Query: 1379 GMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            G    +QG+ GP     +P      G     G  G     GNPG
Sbjct: 376  G----IQGLRGPSGVPGLPALSGVPGALGPQGFPGLKGDQGNPG 415



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 156/632 (24%), Positives = 198/632 (31%), Gaps = 161/632 (25%)

Query: 918  PVHLKSPSLPAPSPGWTSSPK-------PPLQSPGIPPNHKAPLTMASPAMLG-NVESGG 969
            P+ ++ P+ P    G T           P L  P  P   K P  M  P  LG N   G 
Sbjct: 53   PIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGP--MGVPGFLGINGIPGH 110

Query: 970  PPPPTASQP----------ASVNIPGSLPSSTPYTMPP-----------EPTLSQNPLSI 1008
            P  P    P           +V  PG  P   P  + P           +P L+      
Sbjct: 111  PGQPGPRGPPGLDGCNGTQGAVGFPG--PDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKG 168

Query: 1009 M-----MSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNP 1063
            M     +  +     P   P +  A+          PP     L    NM G+G   +  
Sbjct: 169  MKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNM-GLGFQGEKG 227

Query: 1064 ---RISGPNPVVPMPT---LSPMGMTQPLSHSNQMPSPNAV-GPNIPP------------ 1104
                +  P P  P P+   L  MG  +    S   P P    G + PP            
Sbjct: 228  VKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPKGFPGISGPPGFPGLGTTGEKG 287

Query: 1105 ----HGVPMGPGLMSHNPIMGHGSQEPP--MVPQGRMGFP--QGFPPVQSPPQQVPFPHN 1156
                 G+P  PG     P+   G Q PP     +G +GFP   GF  ++     +  P  
Sbjct: 288  EKGEKGIPGLPG--PRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLP-- 343

Query: 1157 GP-----------SGGQGSFPGGMGFPG----------EGPLGRPSNLPQSSADAALCKP 1195
            GP           SG  G  PG  G PG           GP G P     S    AL   
Sbjct: 344  GPDVFIDIDGAVISGNPGD-PGVPGLPGLKGDEGIQGLRGPSGVPGLPALSGVPGALGPQ 402

Query: 1196 GGPG------GPDSFTVLGNSMPSVFTDPDLQEVIRPGATG--IPEFDLSRIIPSEK--P 1245
            G PG       P   T+    +P     P       PG  G   PEF+   +   E   P
Sbjct: 403  GFPGLKGDQGNPGRTTIGAAGLPGRDGLPG-----PPGPPGPPSPEFETETLHNKESGFP 457

Query: 1246 SQTLQYFPRGE------------------VPGRKQPQGPGP----GFSHMQGMMGEQAPR 1283
                +  P+G                   VP    P  PGP    G   + G+ G +  R
Sbjct: 458  GLRGEQGPKGNLGLKGIKGDSGFCACDGGVPNTGPPGEPGPPGPWGLIGLPGLKGARGDR 517

Query: 1284 MGLALPGMGGP-GPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMS------- 1335
                  G GG  GP G P +     PS P      P     QGM G      S       
Sbjct: 518  ------GSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVI 571

Query: 1336 --PAQSTMPGQPTLMSNPAAAVGMIPGKDRGPA--GLYTHPGPVGSPGMMMSMQGMMGPQ 1391
              P +  +PG P L   P       PG+   P   G   HPGP G PG    + G+ GP 
Sbjct: 572  GEPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGN--GLPGLPGP- 628

Query: 1392 QNIMIPPQMRPRGMAADVGMGGFSQGPGNPGN 1423
                       RG+  D G  G     G PG+
Sbjct: 629  -----------RGLPGDKGKDGLPGQQGLPGS 649



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 75/284 (26%), Positives = 99/284 (34%), Gaps = 67/284 (23%)

Query: 1158 PSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTD 1217
            P GGQ        FP +G  GRP  +             GP GP  FT     +  +  +
Sbjct: 29   PCGGQDCSGSCQCFPEKGARGRPGPIGIQ----------GPTGPQGFTG-STGLSGLKGE 77

Query: 1218 PDLQEVIRP-------GATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGF 1270
                 ++ P       G  G+P F     IP                PG+  P+GP PG 
Sbjct: 78   RGFPGLLGPYGPKGDKGPMGVPGFLGINGIPGH--------------PGQPGPRGP-PGL 122

Query: 1271 SHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPH 1330
                G  G            +G PGP G P + LG  P +PG    +    L  G     
Sbjct: 123  DGCNGTQG-----------AVGFPGPDGYPGL-LG-PPGLPGQKGSKGDPVLAPGSF--- 166

Query: 1331 HRMMSPAQSTMPGQPTL--MSNPAAAVGMIPGK--DRGPAGLYTHPGPVGSPG----MMM 1382
                       PG P L  ++ P  A G  PG     GP GL   PGP G  G    M +
Sbjct: 167  -----KGMKGDPGLPGLDGITGPQGAPG-FPGAVGPAGPPGLQGPPGPPGPLGPDGNMGL 220

Query: 1383 SMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQG----PGNPG 1422
              QG  G + ++ +P    P     ++   GF +G     G PG
Sbjct: 221  GFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPG 264



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 63/236 (26%), Positives = 83/236 (35%), Gaps = 40/236 (16%)

Query: 493 QQCSLQDMMVHQHGPRGV-----VRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPR 547
           Q CS       + G RG      ++GP  P   T S G +    E    G+  P+     
Sbjct: 33  QDCSGSCQCFPEKGARGRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYG---- 88

Query: 548 GMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPP 607
                P      M +PGF G IN     P  P P   PGL G +        P    +P 
Sbjct: 89  -----PKGDKGPMGVPGFLG-INGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYP- 141

Query: 608 GQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQR 667
             G+   PG     P  +G   +            L PG + +G    M+ +  +PG   
Sbjct: 142 --GLLGPPG----LPGQKGSKGDPV----------LAPG-SFKG----MKGDPGLPGLDG 180

Query: 668 HMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMV-PSGMKGDVNL 722
              P   P FP     GP  P     P G P  +GP   +  G     G+KGDV L
Sbjct: 181 ITGPQGAPGFP--GAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKGVKGDVGL 234



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 71/315 (22%), Positives = 105/315 (33%), Gaps = 32/315 (10%)

Query: 529  GGTEPFSDGINMPHSLP-PRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGL 587
            G   P   G+  P  LP P+G   +P +       PG  G    +   P +  PA  PG 
Sbjct: 1186 GTPGPSITGVPGPAGLPGPKGEKGYPGIGIGAPGKPGLRGQ-KGDRGFPGLQGPAGLPGA 1244

Query: 588  SGVSWPDDV---------PKI--------PDGRNFPPGQGIFSGPGRGERFPNPQGLSEE 630
             G+S P  +         P +        P G   PPG     G      FP   G    
Sbjct: 1245 PGISLPSLIAGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGP 1304

Query: 631  MFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSR 690
               Q +     GLP  + ++G+R          G+   + P  +P FP +  +G   P  
Sbjct: 1305 KGDQGIPGFS-GLPGELGLKGMRGEPGFM----GTPGKVGPPGDPGFPGM--KGKAGPRG 1357

Query: 691  GDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKL 750
                +G P Q      ++    P G+ G   +    G      P  ++ +   P    K 
Sbjct: 1358 SSGLQGDPGQTPTAEAVQVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKD 1417

Query: 751  RPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRT 810
             P G    P       LP  + P    G       P  QGP    G+      +G     
Sbjct: 1418 GPSGLPGPPGALGDPGLPGLQGPPGFEGA------PGQQGPFGMPGMPGQSMRVGYTLVK 1471

Query: 811  NSRLSHMPPLPLNPS 825
            +S+   +PP P+  S
Sbjct: 1472 HSQSEQVPPCPIGMS 1486



 Score = 34.3 bits (77), Expect = 0.88
 Identities = 23/66 (34%), Positives = 27/66 (40%), Gaps = 3/66 (4%)

Query: 31   PTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAG 90
            P ++ P G P         G  G   +   P P  S +G   P  LPGP G  G   G G
Sbjct: 1158 PGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGP--SITGVPGPAGLPGPKGEKGYP-GIG 1214

Query: 91   NGAKGK 96
             GA GK
Sbjct: 1215 IGAPGK 1220


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score =  101 bits (251), Expect = 6e-21
 Identities = 311/1226 (25%), Positives = 377/1226 (30%), Gaps = 265/1226 (21%)

Query: 267  PAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSA 326
            P     P D+E+ GVE                P   TGP   P   A  P   G      
Sbjct: 96   PDGSESPTDQETTGVEG---------------PKGDTGPRG-PRGPAGPPGRDGIPGQPG 139

Query: 327  DPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSG 386
             P  PP PP   G PP LG N       QL +                 DEK   G    
Sbjct: 140  LP-GPPGPPGPPG-PPGLGGN----FAPQLSYGY---------------DEKSTGGISVP 178

Query: 387  GPQ--QNPGVLDGPQKKPEGPIQAMMAQSQSLGK----GP-GPRTDVGAPF--GPQGHRD 437
            GP     P  L GP   P GP Q         G+    GP GPR   G P   G  G   
Sbjct: 179  GPMGPSGPRGLPGPPGAP-GP-QGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAG 236

Query: 438  VPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQ-IAWLKLQQEFYEEKRRKQEQVVVQQCS 496
             P  P E  PP      G  G   L  M   +  + L   +        K E     +  
Sbjct: 237  KPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENG 296

Query: 497  LQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPF----SDGINMPHSLP-PRGMAP 551
                M    GPRG+           P E   PG   P     +DG       P P G A 
Sbjct: 297  APGQM----GPRGL-----------PGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAG 341

Query: 552  HPNMPGSQMRLPGFAGMINSE-MEGPN-------VPNPASRPGLSGVSWPDDVPKIPDGR 603
             P  PG+ +   G AG       EGP         P PA   G +G    D  P      
Sbjct: 342  PPGFPGA-VGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGAN 400

Query: 604  NFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIP 663
              P   GI   PG    FP  +G S          +  G PPG       P    ++   
Sbjct: 401  GAP---GIAGAPG----FPGARGPS--------GPQGPGGPPGPKGNSGEPGAPGSKGDT 445

Query: 664  GSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMV-PSGMKGDVNL 722
            G++   EPG       + V+GP  P+  +  +G   + GP      G+  P G +G    
Sbjct: 446  GAKG--EPGP------VGVQGPPGPAGEEGKRGARGEPGPT-----GLPGPPGERG---- 488

Query: 723  NVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPR 782
                G  S+  P    +  AGP+             PA ++  P P G  P+   G   R
Sbjct: 489  ----GPGSRGFPGA--DGVAGPKG------------PAGERGSPGPAG--PKGSPGEAGR 528

Query: 783  PFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLG 842
            P      G     GL       GPD +T       PP P      P      PP  RG  
Sbjct: 529  PG---EAGLPGAKGLTGSPGSPGPDGKTG------PPGPAGQDGRPGP--PGPPGARG-- 575

Query: 843  RKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSP--SGNLKSPQTPSQLAGMLAGPA 900
                            G+     P          G P  +G    P  P  +    AG  
Sbjct: 576  --------------QAGVMGFPGP------KGAAGEPGKAGERGVPGPPGAVGP--AGKD 613

Query: 901  AAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKP--PLQSPGIPPNHKAPLTMAS 958
              A  + PP      A P   +    PA SPG+   P P  P    G P     P  + +
Sbjct: 614  GEAGAQGPP----GPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGA 669

Query: 959  PAMLGNVESGGPP-------PPTASQPASVN-IPGSLPSSTPYTMPPEPTLSQNP-LSIM 1009
            P   G     G P       PP  + P   N  PG+  +      P  P     P L  M
Sbjct: 670  PGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGM 729

Query: 1010 MSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPN 1069
                    +P       DA    A         R    P     PG      +   SGP+
Sbjct: 730  PGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPI--GPPGPAGAPGDKGESGPS 787

Query: 1070 PVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPN--IPPHGVPMGPGLMSHNPIMGHGSQEP 1127
                     P G T           P   GP     P G    PG        G      
Sbjct: 788  --------GPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAG 839

Query: 1128 PMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSF--PGGMGFPGEGPLGRPSNLPQ 1185
            P  P G  G P     V +P         G  G +GS   PG  GFPG      P   P 
Sbjct: 840  PPGPAGPAGPPGPIGNVGAP---------GAKGARGSAGPPGATGFPGAAGRVGP---PG 887

Query: 1186 SSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKP 1245
             S +A    P GP G +     G   P   T P      RPG  G          P   P
Sbjct: 888  PSGNAGPPGPPGPAGKE-----GGKGPRGETGP----AGRPGEVG----------PPGPP 928

Query: 1246 SQTLQYFPRGEV--PGRKQPQG----PGP-GFSHMQGMMGEQAPRMGLALPGMGGPGPVG 1298
                   P GE   PG   P G    PGP G +  +G++G    R     PG+  PGP G
Sbjct: 929  G------PAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGL--PGPSG 980

Query: 1299 TPDI--PLGTAPSMPGHNPMRPPAFL----QQGMMGPHHRMMSPAQSTMPGQP-----TL 1347
             P    P G +       PM PP       + G  G      SP +   PG       T 
Sbjct: 981  EPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETG 1040

Query: 1348 MSNPAAAVGM--IPGK--------DRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIP 1397
             + P  A G    PG         DRG  G     GPVG  G      G  GP+ +    
Sbjct: 1041 PAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGAR-GPAGPQGPRGDKGET 1099

Query: 1398 PQMRPRGMAADVGMGGFSQGPGNPGN 1423
             +   RG+    G  G    PG PG+
Sbjct: 1100 GEQGDRGIKGHRGFSGLQGPPGPPGS 1125



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 301/1247 (24%), Positives = 395/1247 (31%), Gaps = 238/1247 (19%)

Query: 213  TERSTAPLNTQISALRNDPKPL-PQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPP 271
            +E  T    T +   + D  P  P+ P  P  +D    Q       P +P P P P  PP
Sbjct: 99   SESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQ-------PGLPGP-PGPPGPP 150

Query: 272  RP-------LDRESPGVENKLIPSVGSPASSTPLPPDGT-GPNSTPNNRAVT--PVSQGS 321
             P         + S G + K    +  P    P  P G  GP   P  +     P   G 
Sbjct: 151  GPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGE 210

Query: 322  NSSSAD--PKAPPPPPVSSGEPPTLGE-NPDGLSQEQLEHRERSLQTLRDIQRMLFPDEK 378
              +S    P+ PP PP  +G+    G+    G          R L     +  M     +
Sbjct: 211  PGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGM--KGHR 268

Query: 379  EFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDV 438
             F+G         P    GP+ +P  P +            PG R   GAP GP G R  
Sbjct: 269  GFSGLDGAKGDAGPA---GPKGEPGSPGENGAPGQMGPRGLPGERGRPGAP-GPAGARGN 324

Query: 439  PFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQ 498
              +     PP     +G  GP       P     +  + E   +  R  E          
Sbjct: 325  DGATGAAGPPG---PTGPAGP-------PGFPGAVGAKGEAGPQGPRGSE---------- 364

Query: 499  DMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGT-----EPFSDGINMPHSLP-------- 545
                   GP+GV   P PP    P+    P G      +P + G N    +         
Sbjct: 365  -------GPQGVRGEPGPP---GPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGA 414

Query: 546  --------------PRGMAPHPNMPGSQ--MRLPGFAGMINSEMEGPNVPNPASR----- 584
                          P+G +  P  PGS+      G  G +   ++GP  P PA       
Sbjct: 415  RGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVG--VQGP--PGPAGEEGKRG 470

Query: 585  ----PGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPG-RGER-FPNPQGLSEEMFQQQLAE 638
                PG +G+  P      P  R FP   G+    G  GER  P P G            
Sbjct: 471  ARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAG------------ 518

Query: 639  KQLGLPPGMAMEGIRPSMEMNRMIPGSQRHM-EPGNNPIFPRIPVEGPLSPSRGDFPKGI 697
                 P G   E  RP       +PG++     PG+     +    GP        P G 
Sbjct: 519  -----PKGSPGEAGRPG---EAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGP 570

Query: 698  PPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDM 757
            P   G    + F   P G  G+              P K  E G  P     + P G D 
Sbjct: 571  PGARGQAGVMGFPG-PKGAAGE--------------PGKAGERGV-PGPPGAVGPAGKDG 614

Query: 758  LPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHM 817
                Q   P P G  P  E G          QGP  + G + L  P GP           
Sbjct: 615  EAGAQGP-PGPAG--PAGERG---------EQGPAGSPGFQGLPGPAGPPGEAGKPGEQG 662

Query: 818  PPLPLN-PSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPML 876
             P  L  P  +        P +RG+   P      G+   +PG +  K            
Sbjct: 663  VPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGAN-GAPGNDGAKGDAGAPGAPGSQ 721

Query: 877  GSPSGNLKSPQTPSQLAGML--------AGPAAAASIKSPPVLG-SAAASPVHLKSPSLP 927
            G+P   L+        AG+         AGP  A    SP   G      P+    P  P
Sbjct: 722  GAPG--LQGMPGERGAAGLPGPKGDRGDAGPKGADG--SPGKDGVRGLTGPI---GPPGP 774

Query: 928  APSPG-----WTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVN 982
            A +PG       S P  P  + G P +   P         G       PP    QP +  
Sbjct: 775  AGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAG-------PPGADGQPGAKG 827

Query: 983  IPGSLPSSTPYTMPPE--PTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSP 1040
             PG   +      P    P     P+  + +  +K A  S+ P    A     ++    P
Sbjct: 828  EPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGP--PGATGFPGAAGRVGP 885

Query: 1041 PARSPNL-PSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVG 1099
            P  S N  P     P      + PR        P      +G   P   + +  SP A G
Sbjct: 886  PGPSGNAGPPGPPGPAGKEGGKGPR----GETGPAGRPGEVGPPGPPGPAGEKGSPGADG 941

Query: 1100 PNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFP-PVQSPPQQVPFPHNGP 1158
            P   P G P   G+     ++G   Q      +G  GFP G P P   P +Q P   +G 
Sbjct: 942  PAGAP-GTPGPQGIAGQRGVVGLPGQ------RGERGFP-GLPGPSGEPGKQGP---SGA 990

Query: 1159 SGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDP 1218
            SG +G  PG MG PG    G P    +  A  A   PG  G P +    G + P+    P
Sbjct: 991  SGERGP-PGPMGPPGLA--GPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPA--GPP 1045

Query: 1219 DLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVP-----GRKQPQGPGPGFSHM 1273
                   PGA G P      + P+ K     +  P G        G + P GP  G    
Sbjct: 1046 GA-----PGAPGAP----GPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGP-QGPRGD 1095

Query: 1274 QGMMGEQAPRMGLALPGMGG-PGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHR 1332
            +G  GEQ  R      G  G  GP G P  P    PS               G  GP   
Sbjct: 1096 KGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPS---------------GASGPAGP 1140

Query: 1333 MMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPG 1379
               P  +  PG+  L   P       P    G AG    PGP G PG
Sbjct: 1141 RGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPG 1187



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 284/1264 (22%), Positives = 382/1264 (30%), Gaps = 261/1264 (20%)

Query: 4    SNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSP 63
            + P+    P+G         Q  +  PP    P G P L   F+ Q   G     +    
Sbjct: 117  TGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGIS 176

Query: 64   CDSKSGGHTPKALPGPGGSMGLKNGAG-NGAKGKGKRERSISADSFDQRDPGTPNDDSDI 122
                 G   P+ LPGP G+ G +   G  G  G    E   S     +  PG P  + D 
Sbjct: 177  VPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPG----EPGASGPMGPRGPPGPPGKNGDD 232

Query: 123  KECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFST 182
             E         +     P        TA       H   +  +       PA        
Sbjct: 233  GEAGKPGR-PGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAG-----PK 286

Query: 183  EMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPA 242
                   E    GQ+                ER          A  ND       PP P 
Sbjct: 287  GEPGSPGENGAPGQM---------GPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPT 337

Query: 243  NQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESP-GVENKLIP--------SVGSPA 293
                         P  P    A   A P  P   E P GV  +  P          G+P 
Sbjct: 338  GPAG--------PPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPG 389

Query: 294  SSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSA--DPKAPPPPPVSSGEPPTLGENPDGL 351
            +     P   G N  P   A  P   G+   S    P  PP P  +SGEP   G   D  
Sbjct: 390  ADG--QPGAKGANGAP-GIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTG 446

Query: 352  SQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMA 411
            ++ +             +Q    P  +E  G +    +  P  L GP  +  GP      
Sbjct: 447  AKGE--------PGPVGVQGPPGPAGEE--GKRGARGEPGPTGLPGPPGERGGPGSRGFP 496

Query: 412  QSQSLGKGPGPRTDVGA--PFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQ 469
             +  +    GP  + G+  P GP+G       P E   P     +G+ G    D  T   
Sbjct: 497  GADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPP 556

Query: 470  IAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPG 529
                                                GP G    P PP          P 
Sbjct: 557  ------------------------------------GPAGQDGRPGPP---------GPP 571

Query: 530  GTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSG 589
            G    +  +  P    P+G A  P   G +  +PG           P    PA + G +G
Sbjct: 572  GARGQAGVMGFP---GPKGAAGEPGKAG-ERGVPG----------PPGAVGPAGKDGEAG 617

Query: 590  VSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAM 649
               P   P  P G      QG    PG  +  P P G                 PPG A 
Sbjct: 618  AQGPPG-PAGPAGER--GEQGPAGSPG-FQGLPGPAG-----------------PPGEA- 655

Query: 650  EGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMG----PGR 705
                                +PG   +   +   GP S +RG+  +G P + G    PG 
Sbjct: 656  -------------------GKPGEQGVPGDLGAPGP-SGARGE--RGFPGERGVQGPPG- 692

Query: 706  ELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMV 765
                   P+G +G      N G+          +AGA      +  PG   M P ++   
Sbjct: 693  -------PAGPRGANGAPGNDGAKG--------DAGAPGAPGSQGAPGLQGM-PGERGAA 736

Query: 766  PLPFGEHPQQEYG-MGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNP 824
             LP    P+ + G  GP+     + G     G+R L  PIGP     +        P  P
Sbjct: 737  GLP---GPKGDRGDAGPKG----ADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGP 789

Query: 825  SSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSP-SGNL 883
             + PT    AP   RG    P     AG     PG +          Q    G P     
Sbjct: 790  -AGPTGARGAPG-DRGEPGPPGPAGFAG----PPGADG---------QPGAKGEPGDAGA 834

Query: 884  KSPQTPSQLAGMLAGPAAAASIKSPPVLGS--AAASPVHLKSPSL------PAPSPGWTS 935
            K    P   AG    P    ++ +P   G+  +A  P     P        P PS G   
Sbjct: 835  KGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPS-GNAG 893

Query: 936  SPKPPLQSPGIPPNHKAPLTMASPA-MLGNVESGGPPPPTASQPASVNIPGSLPSSTPYT 994
             P PP   P      K P     PA   G V   GPP P A +  S    G  P+  P T
Sbjct: 894  PPGPP--GPAGKEGGKGPRGETGPAGRPGEVGPPGPPGP-AGEKGSPGADG--PAGAPGT 948

Query: 995  MPPEPTLSQNPLSIMMSRMSKFAMPS-STPLYHDAIKTVASSDDDSPPARSPNLPSMNNM 1053
              P+    Q  +  +  +  +   P    P      +  + +  +  P      P +   
Sbjct: 949  PGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGP 1008

Query: 1054 PGMGINTQNPRISG-PNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGV----- 1107
            PG       P   G P            G T P        +P A GP + P G      
Sbjct: 1009 PGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGP-VGPAGKSGDRG 1067

Query: 1108 ---PMGPGLMSHNPIMGHGSQEP--PMVPQGRMGFP-----------QGFPPVQSPP--- 1148
               P GP      P+   G++ P  P  P+G  G             +GF  +Q PP   
Sbjct: 1068 ETGPAGPA----GPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPP 1123

Query: 1149 ----QQVPFPHNGPSGGQGSFPGGMGFPGE-------GPLGRPSNLPQSSADAALCKPGG 1197
                +Q P   +GP+G +G  PG  G PG+       GP+G P    + + DA    P G
Sbjct: 1124 GSPGEQGPSGASGPAGPRGP-PGSAGAPGKDGLNGLPGPIGPPGPRGR-TGDAGPVGPPG 1181

Query: 1198 PGGP 1201
            P GP
Sbjct: 1182 PPGP 1185



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 97/338 (28%), Positives = 115/338 (34%), Gaps = 35/338 (10%)

Query: 1101 NIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSG 1160
            N P   VP G       P+   GS+ P       +  P+G    + P      P      
Sbjct: 80   NCPGAEVPEGECC----PVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIP 135

Query: 1161 GQGSFPGGMGFPGE-GPLGRPSNL-PQ--------SSADAALCKPGGPGGPDSFT-VLGN 1209
            GQ   PG  G PG  GP G   N  PQ        S+   ++  P GP GP       G 
Sbjct: 136  GQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGA 195

Query: 1210 SMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEV--PGRKQPQGPG 1267
              P  F  P   E   PGA+G        + P   P    +    GE   PGR   +GP 
Sbjct: 196  PGPQGFQGPP-GEPGEPGASG-------PMGPRGPPGPPGKNGDDGEAGKPGRPGERGP- 246

Query: 1268 PGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTA-PSMPGHNPMRPPAFLQQGM 1326
            PG    +G+ G         LPGM G       D   G A P+ P   P  P      G 
Sbjct: 247  PGPQGARGLPGTAG------LPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQ 300

Query: 1327 MGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMM--MSM 1384
            MGP        +   PG      N  A     P    GPAG    PG VG+ G       
Sbjct: 301  MGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP 360

Query: 1385 QGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            +G  GPQ     P    P G A   G  G    PG  G
Sbjct: 361  RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKG 398



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 200/872 (22%), Positives = 259/872 (29%), Gaps = 133/872 (15%)

Query: 30   PPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGA 89
            P     P+GNP  D +   +G  G       P       G   P    GPGG  G K  +
Sbjct: 378  PAGAAGPAGNPGADGQPGAKGANGAPGIAGAPG----FPGARGPSGPQGPGGPPGPKGNS 433

Query: 90   GNGAKGKGKRERSISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNAT 149
            G                     +PG P    D         +  Q          P+   
Sbjct: 434  G---------------------EPGAPGSKGDTGAKGEPGPVGVQGPPG------PAGEE 466

Query: 150  APRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNIS 209
              R +    G T    P   +  P    +  +  +A     A  +G             +
Sbjct: 467  GKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEA 526

Query: 210  NNKTERSTAPLNTQISALRNDPKPLPQQ-PPAPANQDQNSSQNTRLQPTPPIPA------ 262
                E    P    ++     P P  +  PP PA QD         +P PP P       
Sbjct: 527  GRPGEAGL-PGAKGLTGSPGSPGPDGKTGPPGPAGQDG--------RPGPPGPPGARGQA 577

Query: 263  -----PAPKPAA--PPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNR--A 313
                 P PK AA  P +  +R  PG    + P+     +    PP   GP      +  A
Sbjct: 578  GVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPA 637

Query: 314  VTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPD-GLSQEQLEHRERSLQTLRDIQRM 372
             +P  QG          P  PP  +G+P   G   D G         ER     R +Q  
Sbjct: 638  GSPGFQGL-------PGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGP 690

Query: 373  LFPDEKEFTGAQSG--GPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVG--- 427
              P          G  G + + G    P  +    +Q M  +  + G  PGP+ D G   
Sbjct: 691  PGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGL-PGPKGDRGDAG 749

Query: 428  -----------------APFGPQGHRDVPFSPDEMVPPSMNSQSGTIG-PDHLDHMTPEQ 469
                              P GP G    P    E  P      +G  G P       P  
Sbjct: 750  PKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPG 809

Query: 470  IAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVV--RGPPPPYQMTPSEGW- 526
             A          +   K E                 GP G     GPP P     + G  
Sbjct: 810  PAGFAGPPGADGQPGAKGEPGDAGAKG-------DAGPPGPAGPAGPPGPIGNVGAPGAK 862

Query: 527  ------APGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINS-------EM 573
                   P G   F           P G A  P  PG   +  G      +       E+
Sbjct: 863  GARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEV 922

Query: 574  EGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPG-RGER-FPNPQGLSEEM 631
              P  P PA   G  G   P   P  P  +     +G+   PG RGER FP   G S E 
Sbjct: 923  GPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEP 982

Query: 632  FQQ--QLAEKQLGLPPGMAMEGIR--PSMEMNRMIPGSQRHMEPGNNPIFPRIPVE-GPL 686
             +Q    A  + G P  M   G+   P        PG++       +P       E GP 
Sbjct: 983  GKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPA 1042

Query: 687  SPSRGDFPKGIPPQMGP-GRELEFGMV-PSGMKGDVNLNVNMGSNSQMIPQKMR----EA 740
             P       G P  +GP G+  + G   P+G  G V     +G+     PQ  R    E 
Sbjct: 1043 GPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVG---PVGARGPAGPQGPRGDKGET 1099

Query: 741  GAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYG-MGPRPFLPMSQGPGSNSGLRN 799
            G   +  +K   G S  L         P  + P    G  GPR   P S G     GL  
Sbjct: 1100 GEQGDRGIKGHRGFSG-LQGPPGPPGSPGEQGPSGASGPAGPRG-PPGSAGAPGKDGLNG 1157

Query: 800  LREPIGPD---QRTNSRLSHMPPLPLNPSSNP 828
            L  PIGP     RT       PP P  P   P
Sbjct: 1158 LPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPP 1189



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 61/234 (26%), Positives = 74/234 (31%), Gaps = 33/234 (14%)

Query: 234  LPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRE-SPGVENKLIPSVGSP 292
            LP     P  Q  + +   R    PP P   P  A PP    RE +PG E       GSP
Sbjct: 975  LPGPSGEPGKQGPSGASGER---GPPGPMGPPGLAGPPGESGREGAPGAEGSPGRD-GSP 1030

Query: 293  ASSTPL-------PPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPP--PVSSGEPPT 343
             +           PP   G    P    V P  +  +     P  P  P  PV +   P 
Sbjct: 1031 GAKGDRGETGPAGPPGAPGAPGAPG--PVGPAGKSGDRGETGPAGPAGPVGPVGA-RGPA 1087

Query: 344  LGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPE 403
              + P G   E  E  +R ++  R    +  P      G      +Q P    GP     
Sbjct: 1088 GPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPP-----GPPGSPGEQGPSGASGPAGPRG 1142

Query: 404  GPIQAMMAQSQSLGKGPGP--------RTDVGAPFGPQGHRDVPFSPDEMVPPS 449
             P  A       L   PGP        RT    P GP G    P  P    PPS
Sbjct: 1143 PPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPG---PPS 1193


>gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]
          Length = 1626

 Score =  101 bits (251), Expect = 6e-21
 Identities = 297/1239 (23%), Positives = 392/1239 (31%), Gaps = 249/1239 (20%)

Query: 332  PPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQN 391
            PPPP     PPT G    G               L+ I       EK   G    GP   
Sbjct: 451  PPPPPPPQRPPTPGSEQIGF--------------LKTINCSCPAGEKGEMGV--AGPMGL 494

Query: 392  PGVLDGPQKKPEGPIQAM--------MAQSQSLGKGP------GPRTDVGAPFGP--QGH 435
            PG        P+G I A+          +   +G GP      G +  +G P  P   G 
Sbjct: 495  PG--------PKGDIGAIGPVGAPGPKGEKGDVGIGPFGQGEKGEKGSLGLPGPPGRDGS 546

Query: 436  RDVPFSPDEMVPPSMNSQSGTIGPDHLDHM--TPEQIAWLKLQQEFYEEKRRKQEQVVVQ 493
            + +   P E+  P +  + G  GP     +   P ++    LQ E  E+  R ++     
Sbjct: 547  KGMRGEPGELGEPGLPGEVGMRGPQGPPGLPGPPGRVGAPGLQGERGEKGTRGEK----G 602

Query: 494  QCSLQDM--------MVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLP 545
            +  L              + GP GV         + P+      G+    +G+      P
Sbjct: 603  ERGLDGFPGKPGDTGQQGRPGPSGVAGPQGEKGDVGPAGPPGVPGSVVQQEGLKGEQGAP 662

Query: 546  -PRGMAPHPNMPGSQMRL--------PGFAGM--INSEMEGPNVP------NPASRPGLS 588
             PRG    P  PG++  +        PG  G+     +M  P +P       P   PG+ 
Sbjct: 663  GPRGHQGAPGPPGARGPIGPEGRDGPPGLQGLRGKKGDMGPPGIPGLLGLQGPPGPPGVP 722

Query: 589  GVSWPDDVPKIP--------------------DGRNFPPG-QGIFSGPG-RGE-RFPNPQ 625
            G   P   P +P                    DG N PPG  G    PG RGE   P   
Sbjct: 723  GPPGPGGSPGLPGEIGFPGKPGPPGPTGPPGKDGPNGPPGPPGTKGEPGERGEDGLPGKP 782

Query: 626  GLSEEMFQQQLAEK-----QLGLPPGMAMEGIR--------------PSMEMNRMIPGSQ 666
            GL  E+ +Q LA +     + GLP      G+R              P ++ +R   G  
Sbjct: 783  GLRGEIGEQGLAGRPGEKGEAGLPGAPGFPGVRGEKGDQGEKGELGLPGLKGDRGEKGEA 842

Query: 667  RHME----PGNNPIF---PRIPVEGPLSPSRGDFPKGIPPQMG-PGRELEFGMVPSGMKG 718
                    PG   +F   PR+P E      +GD   G+P + G  GR  E G  P G  G
Sbjct: 843  GPAGPPGLPGTTSLFTPHPRMPGEQGPKGEKGD--PGLPGEPGLQGRPGELG--PQGPTG 898

Query: 719  DVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYG 778
                    G++    P      GA P  +    P G         +   P  +  + E G
Sbjct: 899  PPGAKGQEGAHG--APGAAGNPGA-PGHVGAPGPSGPPGSVGAPGLRGTPGKDGERGEKG 955

Query: 779  MGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQ 838
                   P   GP  + G   L  P G  +     L   P LP      P     A    
Sbjct: 956  AAGEEGSPGPVGPRGDPGAPGLPGPPGKGKDGEPGLRGSPGLP-----GPLGTKAACGKV 1010

Query: 839  RGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAG 898
            RG     L          +PGI    SP          G P   +  P  PS   G    
Sbjct: 1011 RGSENCALGGQCVKGDRGAPGIP--GSPGSR-------GDPGIGVAGPPGPSGPPGDKGS 1061

Query: 899  PAAAASIKSPPVLGSAAASPVHLKSPSLPAP-SPGWTSSPKPPLQSPGIPP--------- 948
            P +      P   G A             AP +PG    P  P  S  + P         
Sbjct: 1062 PGSRGLPGFPGPQGPAGRD---------GAPGNPGERGPPGKPGLSSLLSPGDINLLAKD 1112

Query: 949  --NHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPL 1006
              N   P     P + G     G P     +P      G    + P  +P  P ++  P 
Sbjct: 1113 VCNDCPPGPPGLPGLPGFKGDKGVP----GKPGREGTEGKKGEAGPPGLPGPPGIA-GPQ 1167

Query: 1007 SIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRIS 1066
                 R +   +       H  +        +  P  +  +      P  GI     +  
Sbjct: 1168 GSQGERGADGEVGQKGDQGHPGVPGFMGPPGNPGPPGADGIAGAAGPP--GIQGSPGKEG 1225

Query: 1067 GPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVG----PNIP-PHGVPMGPGLMSHNPIMG 1121
             P P  P       G         +   P   G    P +P P G    PG   H    G
Sbjct: 1226 PPGPQGPSGLPGIPGEEGKEGRDGKPGPPGEPGKAGEPGLPGPEGARGPPGFKGHT---G 1282

Query: 1122 HGSQEPPMVPQGRMGFP--QGFPPVQSPP----QQVPFPHNGPSGGQGSFPGGMGFPGEG 1175
                  P    G MG P  +G P           Q P    GP G  GS PG  G P  G
Sbjct: 1283 DSGAPGPRGESGAMGLPGQEGLPGKDGDTGPTGPQGPQGPRGPPGKNGS-PGSPGEP--G 1339

Query: 1176 PLGRPSNLPQSSADAALCKPG--GPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPE 1233
            P G P        + +   PG  GP GP          P     P  + V  PG  G P 
Sbjct: 1340 PSGTPGQKGSKGENGSPGLPGFLGPRGPP-------GEPGEKGVPGKEGV--PGKPGEPG 1390

Query: 1234 FDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPG-PGFSHMQGMMGEQAPRMGLALPG-- 1290
            F   R  P  K         +G   G+ QP  PG PG     G+MG Q       LPG  
Sbjct: 1391 FKGERGDPGIKGD-------KGPPGGKGQPGDPGIPGHKGHTGLMGPQ------GLPGEN 1437

Query: 1291 --MGGPGPVGTPDIP--LGTAPSMPGHNPM-------------------RPPAFLQ--QG 1325
              +G PGP G P  P   G +PSM     +                    PPA+++  QG
Sbjct: 1438 GPVGPPGPPGQPGFPGLRGESPSMETLRRLIQEELGKQLETRLAYLLAQMPPAYMKSSQG 1497

Query: 1326 MMGPHHRMMSPAQSTMPGQPTLMSNPA-AAVGMIPGKDRGPAGLYTHPGPVGSPGMM-MS 1383
              GP      P +  +PG+   M  P     G + G   GP G     G  G PG   + 
Sbjct: 1498 RPGPPG---PPGKDGLPGRAGPMGEPGRPGQGGLEGPS-GPIGPKGERGAKGDPGAPGVG 1553

Query: 1384 MQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            ++G MGP     IP Q    G A D G+ G     G  G
Sbjct: 1554 LRGEMGPPG---IPGQPGEPGYAKD-GLPGIPGPQGETG 1588



 Score = 97.8 bits (242), Expect = 6e-20
 Identities = 304/1255 (24%), Positives = 399/1255 (31%), Gaps = 327/1255 (26%)

Query: 231  PKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVG 290
            P P PQ+PP P ++     +          PA          P+    P  +   I  VG
Sbjct: 453  PPPPPQRPPTPGSEQIGFLKTINCS----CPAGEKGEMGVAGPMGLPGPKGDIGAIGPVG 508

Query: 291  SPA-----SSTPLPPDGTGPNSTPNNRAVT--PVSQGSNSSSADP--------------K 329
            +P          + P G G      +  +   P   GS     +P              +
Sbjct: 509  APGPKGEKGDVGIGPFGQGEKGEKGSLGLPGPPGRDGSKGMRGEPGELGEPGLPGEVGMR 568

Query: 330  APPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQ 389
             P  PP   G P  +G    GL  E+ E   R  +  R +    FP +   TG Q G P 
Sbjct: 569  GPQGPPGLPGPPGRVGA--PGLQGERGEKGTRGEKGERGLDG--FPGKPGDTG-QQGRP- 622

Query: 390  QNPGVLDGPQKK-----PEGP--IQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSP 442
              P  + GPQ +     P GP  +   + Q + L      + + GAP GP+GH+  P  P
Sbjct: 623  -GPSGVAGPQGEKGDVGPAGPPGVPGSVVQQEGL------KGEQGAP-GPRGHQGAPGPP 674

Query: 443  DEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMV 502
                        G IGP+  D   P  +  L+ ++                     DM  
Sbjct: 675  ---------GARGPIGPEGRDG--PPGLQGLRGKKG--------------------DM-- 701

Query: 503  HQHGPRGV-----VRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPG 557
               GP G+     ++GPP P          PG                     P P  PG
Sbjct: 702  ---GPPGIPGLLGLQGPPGP----------PG--------------------VPGPPGPG 728

Query: 558  SQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGR 617
                LPG  G        P  P P   PG  G          P+G   PPG     G   
Sbjct: 729  GSPGLPGEIGFPGK----PGPPGPTGPPGKDG----------PNGPPGPPGTKGEPGERG 774

Query: 618  GERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIF 677
             +  P   GL  E+ +Q LA               RP  +    +PG+         P F
Sbjct: 775  EDGLPGKPGLRGEIGEQGLAG--------------RPGEKGEAGLPGA---------PGF 811

Query: 678  PRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKM 737
            P +  E      +GD           G + E G+   G+KGD                + 
Sbjct: 812  PGVRGE------KGD----------QGEKGELGL--PGLKGDRG--------------EK 839

Query: 738  REAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPR-----PFLPMSQGPG 792
             EAG          P G   LP    +    F  HP+     GP+     P LP   G  
Sbjct: 840  GEAG----------PAGPPGLPGTTSL----FTPHPRMPGEQGPKGEKGDPGLPGEPGLQ 885

Query: 793  SNSGLRNLREPIGPDQRTNSRLSHMPPLPLN------------PSSNPTSLNTAPPVQRG 840
               G    + P GP        +H  P                PS  P S+    P  RG
Sbjct: 886  GRPGELGPQGPTGPPGAKGQEGAHGAPGAAGNPGAPGHVGAPGPSGPPGSVGA--PGLRG 943

Query: 841  LGRKPLDISVAGS--QVHSPG-INPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLA 897
               K  +    G+  +  SPG + P   P      +P L  P G  K  +   + +  L 
Sbjct: 944  TPGKDGERGEKGAAGEEGSPGPVGPRGDPG-----APGLPGPPGKGKDGEPGLRGSPGLP 998

Query: 898  GP----AAAASIKSPP--VLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHK 951
            GP    AA   ++      LG          +P +P  SPG  S   P +   G P    
Sbjct: 999  GPLGTKAACGKVRGSENCALGGQCVKGDR-GAPGIPG-SPG--SRGDPGIGVAGPPGPSG 1054

Query: 952  APLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMS 1011
             P    SP   G     GP  P     A    PG+     P   P +P LS         
Sbjct: 1055 PPGDKGSPGSRGLPGFPGPQGPAGRDGA----PGNPGERGP---PGKPGLSS-------- 1099

Query: 1012 RMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPV 1071
                   P    L     K V +     PP   P LP      G+          G    
Sbjct: 1100 ----LLSPGDINLL---AKDVCNDCPPGPPGL-PGLPGFKGDKGVPGKPGREGTEGKKGE 1151

Query: 1072 VPMPTL-SPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMV 1130
               P L  P G+  P     +  +   VG      G P  PG M        G+  PP  
Sbjct: 1152 AGPPGLPGPPGIAGPQGSQGERGADGEVGQK-GDQGHPGVPGFMGPP-----GNPGPPGA 1205

Query: 1131 P--QGRMGFP--QGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQS 1186
                G  G P  QG P  + PP        GPSG  G  PG  G  G      P   P  
Sbjct: 1206 DGIAGAAGPPGIQGSPGKEGPPGP-----QGPSGLPG-IPGEEGKEGRDGKPGPPGEPGK 1259

Query: 1187 SADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPS 1246
            + +  L  P G  GP  F   G++  S    P  +     GA G+P              
Sbjct: 1260 AGEPGLPGPEGARGPPGFK--GHTGDSGAPGPRGES----GAMGLP-------------- 1299

Query: 1247 QTLQYFPRGEVPGRKQPQGP-GPGFSHMQGMMGEQAPRMGLALPGM-GGPGPVGTP---- 1300
                   +  +PG+    GP GP     QG  G + P      PG  G PGP GTP    
Sbjct: 1300 ------GQEGLPGKDGDTGPTGP-----QGPQGPRGPPGKNGSPGSPGEPGPSGTPGQKG 1348

Query: 1301 DIPLGTAPSMPGH-NPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIP 1359
                  +P +PG   P  PP   + G  G   +   P +   PG      +P      I 
Sbjct: 1349 SKGENGSPGLPGFLGPRGPPG--EPGEKGVPGKEGVPGKPGEPGFKGERGDPG-----IK 1401

Query: 1360 GKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGF 1414
            G D+GP G    PG  G PG      G+MGPQ    +P +  P G     G  GF
Sbjct: 1402 G-DKGPPGGKGQPGDPGIPG-HKGHTGLMGPQG---LPGENGPVGPPGPPGQPGF 1451



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 113/444 (25%), Positives = 152/444 (34%), Gaps = 89/444 (20%)

Query: 1031 TVASSDDDSPPARSPNLPSMNNMPGMG-INTQNPRISGPNPVVPMPTLSPMGMTQPLSHS 1089
            TV +     PP + P  P    +  +  IN   P          M    PMG+  P    
Sbjct: 446  TVVTEPPPPPPPQRPPTPGSEQIGFLKTINCSCPA----GEKGEMGVAGPMGLPGPKGDI 501

Query: 1090 NQMPSPNAVGPN-------IPPHG-----------VPMGPGLMSHNPIMGHGSQ--EPPM 1129
              +    A GP        I P G           +P  PG      + G   +  EP +
Sbjct: 502  GAIGPVGAPGPKGEKGDVGIGPFGQGEKGEKGSLGLPGPPGRDGSKGMRGEPGELGEPGL 561

Query: 1130 VPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSAD 1189
              +  M  PQG P +  PP +V  P  G  G +G   G  G  GE  L      P  +  
Sbjct: 562  PGEVGMRGPQGPPGLPGPPGRVGAP--GLQGERGE-KGTRGEKGERGLDGFPGKPGDTGQ 618

Query: 1190 AALCKPGGPGGPDSFT-VLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQT 1248
                 P G  GP      +G + P       +Q+    G  G P                
Sbjct: 619  QGRPGPSGVAGPQGEKGDVGPAGPPGVPGSVVQQEGLKGEQGAPG--------------- 663

Query: 1249 LQYFPRGE-----VPGRKQPQGP-----GPGFSHMQGMMGEQAPRMGLALPGM----GGP 1294
                PRG       PG + P GP      PG   ++G  G+  P     +PG+    G P
Sbjct: 664  ----PRGHQGAPGPPGARGPIGPEGRDGPPGLQGLRGKKGDMGPP---GIPGLLGLQGPP 716

Query: 1295 GPVGTPDIP-LGTAPSMPGH----------NPMRPPA-FLQQGMMGPHHRMMSP---AQS 1339
            GP G P  P  G +P +PG            P  PP      G  GP      P    + 
Sbjct: 717  GPPGVPGPPGPGGSPGLPGEIGFPGKPGPPGPTGPPGKDGPNGPPGPPGTKGEPGERGED 776

Query: 1340 TMPGQPTLMSN-PAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPP 1398
             +PG+P L        +   PG ++G AGL   PG  G PG +   +G  G +  + +P 
Sbjct: 777  GLPGKPGLRGEIGEQGLAGRPG-EKGEAGL---PGAPGFPG-VRGEKGDQGEKGELGLPG 831

Query: 1399 QMRPRGMAADVGMGGFSQGPGNPG 1422
                RG   + G  G    PG PG
Sbjct: 832  LKGDRGEKGEAGPAG---PPGLPG 852



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 221/944 (23%), Positives = 293/944 (31%), Gaps = 195/944 (20%)

Query: 292  PASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGEN---- 347
            PA    LP  GT    TP+ R   P  QG      DP  P  P +  G P  LG      
Sbjct: 844  PAGPPGLP--GTTSLFTPHPRM--PGEQGPKGEKGDPGLPGEPGLQ-GRPGELGPQGPTG 898

Query: 348  PDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQ 407
            P G   ++  H                P      GA   GP   PG +  P  +      
Sbjct: 899  PPGAKGQEGAHGAPGAAGN--------PGAPGHVGAP--GPSGPPGSVGAPGLRGTPGKD 948

Query: 408  AMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSM--NSQSGTIGPDHLDHM 465
                +  + G+   P        GP G R  P +P    PP    + + G  G   L   
Sbjct: 949  GERGEKGAAGEEGSP--------GPVGPRGDPGAPGLPGPPGKGKDGEPGLRGSPGLPGP 1000

Query: 466  TPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDM----MVHQHGPRGV----VRGPPPP 517
               + A  K+        R  +   +  QC   D     +    G RG     V GPP P
Sbjct: 1001 LGTKAACGKV--------RGSENCALGGQCVKGDRGAPGIPGSPGSRGDPGIGVAGPPGP 1052

Query: 518  YQMTPSEGWAPGGTEPFSDGI-NMPHSLPPRGMAPHPNMPG----------SQMRLPGFA 566
                P +  +PG     S G+   P    P G    P  PG          S +  PG  
Sbjct: 1053 -SGPPGDKGSPG-----SRGLPGFPGPQGPAGRDGAPGNPGERGPPGKPGLSSLLSPGDI 1106

Query: 567  GMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQG 626
             ++  ++     P P   PGL G      VP  P GR    G+   +GP      P P G
Sbjct: 1107 NLLAKDVCNDCPPGPPGLPGLPGFKGDKGVPGKP-GREGTEGKKGEAGP---PGLPGPPG 1162

Query: 627  LSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPL 686
            ++      Q ++ + G    +  +G       ++  PG    M P  NP  P     G  
Sbjct: 1163 IAGP----QGSQGERGADGEVGQKG-------DQGHPGVPGFMGPPGNPGPP-----GAD 1206

Query: 687  SPSRGDFPKGIPPQMGPGRELEFG-MVPSGMKGDVNLNVNMGSNSQMIPQ----KMREAG 741
              +    P GI  Q  PG+E   G   PSG+ G        G + +  P     K  E G
Sbjct: 1207 GIAGAAGPPGI--QGSPGKEGPPGPQGPSGLPGIPGEEGKEGRDGKPGPPGEPGKAGEPG 1264

Query: 742  AGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLR 801
                E  +  PG            P P GE      G+  +  LP   G    +G +  +
Sbjct: 1265 LPGPEGARGPPGFKGH--TGDSGAPGPRGESGAM--GLPGQEGLPGKDGDTGPTGPQGPQ 1320

Query: 802  EPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGIN 861
             P GP  +  S     P  P  P  + T      P Q+G          +  +  SPG+ 
Sbjct: 1321 GPRGPPGKNGS-----PGSPGEPGPSGT------PGQKG----------SKGENGSPGLP 1359

Query: 862  PLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHL 921
                P     +    G P G    P  P +       P        P + G         
Sbjct: 1360 GFLGPRGPPGEPGEKGVP-GKEGVPGKPGE-------PGFKGERGDPGIKGD-------- 1403

Query: 922  KSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASV 981
            K P      PG    P      PGIP  HK    +  P  L        PP    QP   
Sbjct: 1404 KGP------PGGKGQPG----DPGIP-GHKGHTGLMGPQGLPGENGPVGPPGPPGQPGFP 1452

Query: 982  NIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPP 1041
             + G  PS     M     L Q  L   +     + +    P Y      + SS     P
Sbjct: 1453 GLRGESPS-----METLRRLIQEELGKQLETRLAYLLAQMPPAY------MKSSQGRPGP 1501

Query: 1042 ARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPN 1101
               P  P  + +PG       P   G   +       P G   P         P A G  
Sbjct: 1502 ---PGPPGKDGLPGRAGPMGEPGRPGQGGLE-----GPSGPIGPKGERGAKGDPGAPGVG 1553

Query: 1102 I----PPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNG 1157
            +     P G+P  PG             EP     G  G P             P    G
Sbjct: 1554 LRGEMGPPGIPGQPG-------------EPGYAKDGLPGIPG------------PQGETG 1588

Query: 1158 PSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGP 1201
            P+G  G  PG  G PG+     PS     ++ AA  +PG   GP
Sbjct: 1589 PAGHPG-LPGPPGPPGQCD---PSQCAYFASLAA--RPGNVKGP 1626



 Score = 47.8 bits (112), Expect = 8e-05
 Identities = 100/424 (23%), Positives = 143/424 (33%), Gaps = 80/424 (18%)

Query: 233  PLPQQPPA-PANQDQNSSQNTRLQPTPP-IPAPAPKPAAPPRPLDRESPGVENKLIPSVG 290
            P PQ P   P    +   +    +P PP  P  A +P  P     R  PG +        
Sbjct: 1227 PGPQGPSGLPGIPGEEGKEGRDGKPGPPGEPGKAGEPGLPGPEGARGPPGFKGH------ 1280

Query: 291  SPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSAD--PKAPPPPPVSSGEPPTLGE-N 347
            +  S  P P   +G    P    + P   G    +    P+ P  PP  +G P + GE  
Sbjct: 1281 TGDSGAPGPRGESGAMGLPGQEGL-PGKDGDTGPTGPQGPQGPRGPPGKNGSPGSPGEPG 1339

Query: 348  PDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKK--PEGP 405
            P G   ++    E              P    F G +  GP   PG    P K+  P  P
Sbjct: 1340 PSGTPGQKGSKGENG-----------SPGLPGFLGPR--GPPGEPGEKGVPGKEGVPGKP 1386

Query: 406  IQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDE------MVPPSMNSQSGTIGP 459
             +      +     PG + D G P G +G    P  P        M P  +  ++G +GP
Sbjct: 1387 GEPGFKGERG---DPGIKGDKGPP-GGKGQPGDPGIPGHKGHTGLMGPQGLPGENGPVGP 1442

Query: 460  ---------DHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGV 510
                       L   +P      +L QE   ++   +   ++ Q     M   Q  P   
Sbjct: 1443 PGPPGQPGFPGLRGESPSMETLRRLIQEELGKQLETRLAYLLAQMPPAYMKSSQGRP--- 1499

Query: 511  VRGPPPPYQMTPSEGWAPGGTEPFSD-------GINMPHS-LPPRGMAPHPNMPGSQMRL 562
              GPP P    P +   PG   P  +       G+  P   + P+G       PG+    
Sbjct: 1500 --GPPGP----PGKDGLPGRAGPMGEPGRPGQGGLEGPSGPIGPKGERGAKGDPGA---- 1549

Query: 563  PGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFP 622
            PG    +  EM  P +P     PG +     D +P IP     P G+   +GP      P
Sbjct: 1550 PGVG--LRGEMGPPGIPGQPGEPGYA----KDGLPGIPG----PQGE---TGPAGHPGLP 1596

Query: 623  NPQG 626
             P G
Sbjct: 1597 GPPG 1600



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 65/232 (28%), Positives = 90/232 (38%), Gaps = 30/232 (12%)

Query: 1205 TVLGNSM-PSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQP 1263
            TV+G  +  SV  D DLQ ++    +   E +    IPS     T+   P    P ++ P
Sbjct: 402  TVIGKRLYDSVPIDFDLQRIVIYCDSRHAELETCCDIPSGPCQVTVVTEPPPPPPPQRPP 461

Query: 1264 QGPGP---GF------SHMQGMMGEQAPRMGLALPG----MGGPGPVGTPDIPLGTAPSM 1310
              PG    GF      S   G  GE      + LPG    +G  GPVG P  P G    +
Sbjct: 462  T-PGSEQIGFLKTINCSCPAGEKGEMGVAGPMGLPGPKGDIGAIGPVGAPG-PKGEKGDV 519

Query: 1311 PGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYT 1370
             G  P       ++G +G            M G+P  +  P     +     +GP GL  
Sbjct: 520  -GIGPFGQGEKGEKGSLGLPGPPGRDGSKGMRGEPGELGEPGLPGEVGMRGPQGPPGLPG 578

Query: 1371 HPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
             PG VG+PG    +QG  G         +   RG   + G+ GF   PG+ G
Sbjct: 579  PPGRVGAPG----LQGERG---------EKGTRGEKGERGLDGFPGKPGDTG 617



 Score = 30.8 bits (68), Expect = 9.7
 Identities = 24/92 (26%), Positives = 32/92 (34%), Gaps = 7/92 (7%)

Query: 30   PPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGA 89
            PP    PSG P +  +   +G+ G      +P     K+G      LPGP G+ G     
Sbjct: 1226 PPGPQGPSGLPGIPGEEGKEGRDGKPGPPGEP----GKAG---EPGLPGPEGARGPPGFK 1278

Query: 90   GNGAKGKGKRERSISADSFDQRDPGTPNDDSD 121
            G+         R  S         G P  D D
Sbjct: 1279 GHTGDSGAPGPRGESGAMGLPGQEGLPGKDGD 1310


>gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]
          Length = 1499

 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 293/1177 (24%), Positives = 376/1177 (31%), Gaps = 270/1177 (22%)

Query: 384  QSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPD 443
            Q G P   P V+ G + +P GP     +Q     +GP  R     P G  G   VP  P 
Sbjct: 114  QKGEPGLVP-VVTGIRGRP-GPAGPPGSQGPRGERGPKGRPGPRGPQGIDGEPGVPGQPG 171

Query: 444  EMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVH 503
               PP   S  G   PD L      Q+A L       +EK     QV +   S+  +   
Sbjct: 172  APGPPGHPSHPG---PDGLSRPFSAQMAGL-------DEKSGLGSQVGLMPGSVGPV--- 218

Query: 504  QHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLP 563
              GPRG       P  +   +G A G T P                   P  PG     P
Sbjct: 219  --GPRG-------PQGLQGQQGGA-GPTGP-------------------PGEPGD----P 245

Query: 564  GFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPN 623
            G  G I S   GP    P  +PG  G            GRN  PG+  F+G      FP 
Sbjct: 246  GPMGPIGSR--GPE--GPPGKPGEDG----------EPGRNGNPGEVGFAGSPGARGFPG 291

Query: 624  PQGLSEEMFQQQLAEKQLGLPPGMAMEGIR-PSMEMNRMIPGSQRHMEPGNNPIFPRIPV 682
              GL              GL      +G+  P  E+    PGS+    P        +  
Sbjct: 292  APGLP-------------GLKGHRGHKGLEGPKGEVGA--PGSKGEAGPTGP-----MGA 331

Query: 683  EGPLSP-----SRGDF-PKGIPPQMG----PGRELEFGMVPSGMKGDVNLNVNMGSNSQM 732
             GPL P      RG   P+G P Q G    PG+    G  P G+ G      N G   + 
Sbjct: 332  MGPLGPRGMPGERGRLGPQGAPGQRGAHGMPGKPGPMG--PLGIPGSSGFPGNPGMKGEA 389

Query: 733  IPQKMREAGAGPEEMLKLR--------------PG--GSDMLPAQQKMVPLPFGEHPQQE 776
             P   R    GPE     R              PG  G+D  P  +     P    P   
Sbjct: 390  GPTGAR----GPEGPQGQRGETGPPGPVGSPGLPGAIGTDGTPGAKGPTGSPGTSGPPGS 445

Query: 777  YG----------MGPR-----------PFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLS 815
             G           GP+           P      GP    G   ++ PIGP      R  
Sbjct: 446  AGPPGSPGPQGSTGPQGIRGQPGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGKR-- 503

Query: 816  HMPPLPLNPSSNPTSLNTAPPV-QRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSP 874
                    P  +P ++    PV +RG          A      PG + L  P   Q +  
Sbjct: 504  -------GPRGDPGTVGPPGPVGERG----------APGNRGFPGSDGLPGPKGAQGERG 546

Query: 875  MLGS--PSGNLKSPQTPSQ--LAGMLA--------------GPAAAASIKSPPVLGSAAA 916
             +GS  P G+   P  P +  L G                 GP  A      P  G   +
Sbjct: 547  PVGSSGPKGSQGDPGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRP--GPPGS 604

Query: 917  SPVHLKSPSLPAPSP-GWTSSPKPPLQS--PGIPPNHKAPLT---------MASPAMLGN 964
              +  +  S+  P P G +  P  P ++   G+P    AP           +  P + G 
Sbjct: 605  IGIRGQPGSMGLPGPKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGE 664

Query: 965  VESGGPPPPTASQ--PASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMS--KFAMPS 1020
                GPP PT  Q  P     PG         +P +P  +  PL     R +  +   P 
Sbjct: 665  RGEQGPPGPTGFQGLPGPPGPPGEGGKPGDQGVPGDPG-AVGPLGPRGERGNPGERGEPG 723

Query: 1021 STPLYHDAIKTVASSDDDSPPARSPN---LPSMNNMPGM-GINTQNPRISGPNPVVPMPT 1076
             T L  +  K +A       P  SP     P     PG+ G+  +      P P      
Sbjct: 724  ITGLPGE--KGMAGGHGPDGPKGSPGPSGTPGDTGPPGLQGMPGERGIAGTPGPKGDRGG 781

Query: 1077 LSPMGMTQPLSHSNQMPSPNAVGPNIPP-----HGVPMGPGLMSHNPIMGHGSQEPPMVP 1131
            +   G      +      P  +GP  P       G P   GL+      G+        P
Sbjct: 782  IGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGP 841

Query: 1132 QGRMGF-----PQGFPPVQSPPQQV-----------------PFPHN-----GPSGGQGS 1164
             G +GF     P G P V+  P +                  P PH      G  GG+G+
Sbjct: 842  TGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGT 901

Query: 1165 F--PGGMGFPGE-------GPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVF 1215
               PG  GFPG        GP G P              PG  G P S   +G+  P+  
Sbjct: 902  QGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDPGSHGRVGDRGPA-- 959

Query: 1216 TDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEV--PGRKQPQGPGPGFSHM 1273
              P       PG  G P  D  +  P   P        RG V  PG++  +G  PG    
Sbjct: 960  GPPG-----GPGDKGDPGED-GQPGPDGPPGPAGTTGQRGIVGMPGQRGERGM-PGLPGP 1012

Query: 1274 QGMMGEQAPRMGLALPGMGGPGPVGTPDI--PLGT-APSMPGHN---PMRPPAFLQQGMM 1327
             G  G+  P    A    G PGPVG P    P+G   P  P  N   P R  A  ++G  
Sbjct: 1013 AGTPGKVGPTG--ATGDKGPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDR 1070

Query: 1328 GPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGM--MMSMQ 1385
            G       P     PG P     P  A G     D G  G     GP+G PG      + 
Sbjct: 1071 GDPGPAGLPGSQGAPGTP----GPVGAPG-----DAGQRGDPGSRGPIGPPGRAGKRGLP 1121

Query: 1386 GMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            G  GP+ +         RG     G  G    PG PG
Sbjct: 1122 GPQGPRGDKGDHGDRGDRGQKGHRGFTGLQGLPGPPG 1158



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 320/1255 (25%), Positives = 396/1255 (31%), Gaps = 267/1255 (21%)

Query: 282  ENKLIPSV----GSPASSTPLPPDGT----GPNSTPNNRAVTPVSQGSNSSSADPKAPPP 333
            E  L+P V    G P  + P    G     GP   P  R    +  G       P AP P
Sbjct: 117  EPGLVPVVTGIRGRPGPAGPPGSQGPRGERGPKGRPGPRGPQGID-GEPGVPGQPGAPGP 175

Query: 334  PPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPG 393
            P    G P   G  PDGLS      R  S Q       M   DEK   G+Q G    + G
Sbjct: 176  P----GHPSHPG--PDGLS------RPFSAQ-------MAGLDEKSGLGSQVGLMPGSVG 216

Query: 394  VLDGPQKKPEGPIQAMMAQSQSLGKGP-GPRTDVG-----APFGPQGHRDVPFSPDEMVP 447
                    P GP      Q Q  G GP GP  + G      P G +G    P  P E   
Sbjct: 217  --------PVGPRGPQGLQGQQGGAGPTGPPGEPGDPGPMGPIGSRGPEGPPGKPGEDGE 268

Query: 448  PSMNSQSGTIG----PDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVH 503
            P  N   G +G    P          +  LK  +     +  K E  V    S  +    
Sbjct: 269  PGRNGNPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGE--VGAPGSKGE--AG 324

Query: 504  QHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGIN----MPHSLPPRGMAPHPNMPGSQ 559
              GP G + GP  P  M    G       P   G +     P  + P G+      PG+ 
Sbjct: 325  PTGPMGAM-GPLGPRGMPGERGRLGPQGAPGQRGAHGMPGKPGPMGPLGIPGSSGFPGNP 383

Query: 560  MRLPGFAGMINSE-MEGPN-------VPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGI 611
              + G AG   +   EGP         P P   PGL G    D  P    G   P G   
Sbjct: 384  -GMKGEAGPTGARGPEGPQGQRGETGPPGPVGSPGLPGAIGTDGTP----GAKGPTGSPG 438

Query: 612  FSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEP 671
             SGP      P   G                 PPG                PG Q    P
Sbjct: 439  TSGP------PGSAG-----------------PPGS---------------PGPQGSTGP 460

Query: 672  GN---NPIFPRIP-VEGPLSPSRGDFPKGIPPQMGP-GRELEFGMVPSGMKGDVNLNVNM 726
                  P  P +P  +G   P     P GI   +GP G E + G  P G  G V      
Sbjct: 461  QGIRGQPGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGKRG--PRGDPGTVGP---- 514

Query: 727  GSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLP----AQQKMVPL----PFGEHPQQEYG 778
                   P  + E GA           GSD LP    AQ +  P+    P G   Q + G
Sbjct: 515  -------PGPVGERGAPGNRGFP----GSDGLPGPKGAQGERGPVGSSGPKGS--QGDPG 561

Query: 779  MGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNT-APPV 837
                P LP ++G   N G++     +GP           PP  +     P S+    P  
Sbjct: 562  RPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKG 621

Query: 838  QRGLGRKPLDISVAG--SQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGM 895
              G   KP +   AG   Q  +PG +    P+   V  P L    G    P         
Sbjct: 622  SSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPS-GPVGPPGLAGERGEQGPP--------- 671

Query: 896  LAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLT 955
              GP     +  PP        P     P  P         P  P    G P     P  
Sbjct: 672  --GPTGFQGLPGPPGPPGEGGKPGDQGVPGDPG-----AVGPLGPRGERGNPGERGEPGI 724

Query: 956  MASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSK 1015
               P   G     GP  P  S P     PG         MP E  ++  P      R   
Sbjct: 725  TGLPGEKGMAGGHGPDGPKGS-PGPSGTPGDTGPPGLQGMPGERGIAGTP-GPKGDRGGI 782

Query: 1016 FAMPSSTPLYHDAIKTVASSDDDSPPAR------SPNLPSMNNMPGMGINTQNPRISGPN 1069
                +     +D  + +        PA        P    +   PG   N  +   +GP 
Sbjct: 783  GEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPT 842

Query: 1070 PVVPM-----PTLSPMGMTQPLSHSNQ----MPSPNAVGPNIPPHGVPMGPGLMSHNPIM 1120
              V       P   P    +P     +     P P  +  +  PHG    PGL       
Sbjct: 843  GAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKG----- 897

Query: 1121 GHGSQEPPMVPQGRMGFPQGFPPVQSP-PQQVPFPHNGPSG--GQGSFPGGMGFPGE--- 1174
            G G+Q PP    G  GFP     V  P P   P P  GP G  G+   PG  G PG    
Sbjct: 898  GRGTQGPP----GATGFPGSAGRVGPPGPAGAPGPA-GPLGEPGKEGPPGLRGDPGSHGR 952

Query: 1175 ----GPLGRPSNLPQSSADAALCKPG--GPGGPDSFT----VLGNSMPSVFTDPDLQEVI 1224
                GP G P             +PG  GP GP   T    ++G  MP    +  +  + 
Sbjct: 953  VGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVG--MPGQRGERGMPGL- 1009

Query: 1225 RPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEV--PGRKQPQG-PGP-------GFSHMQ 1274
             PG  G P     ++ P+     T    P G V  PG   P G PGP       G     
Sbjct: 1010 -PGPAGTP----GKVGPT---GATGDKGPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRD 1061

Query: 1275 GMMGEQAPRMG---LALPGMGG----PGPVGTPDIPLGTAPSMPGHNPMRPPAFL-QQGM 1326
            G +GE+  R       LPG  G    PGPVG P    G         P+ PP    ++G+
Sbjct: 1062 GAVGERGDRGDPGPAGLPGSQGAPGTPGPVGAPG-DAGQRGDPGSRGPIGPPGRAGKRGL 1120

Query: 1327 MGPH-------------------HRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAG 1367
             GP                    HR  +  Q  +PG P       +A    P   RGP  
Sbjct: 1121 PGPQGPRGDKGDHGDRGDRGQKGHRGFTGLQG-LPGPPGPNGEQGSAGIPGPFGPRGP-- 1177

Query: 1368 LYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
                PGPVG  G   +  G +GP         + P G+   VG  G    PG PG
Sbjct: 1178 ----PGPVGPSGKEGN-PGPLGP---------IGPPGVRGSVGEAGPEGPPGEPG 1218



 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 309/1263 (24%), Positives = 387/1263 (30%), Gaps = 308/1263 (24%)

Query: 256  PTPPIPAPAPKPAAPPRPLDRESPGVENK--LIPSVG-SPASSTPLPPDG---------- 302
            P PP     P P    RP   +  G++ K  L   VG  P S  P+ P G          
Sbjct: 173  PGPPGHPSHPGPDGLSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPVGPRGPQGLQGQQGG 232

Query: 303  ---TGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHR 359
               TGP   P +    P   G   S   P+ PP  P   GEP   G              
Sbjct: 233  AGPTGPPGEPGD----PGPMGPIGSRG-PEGPPGKPGEDGEPGRNGN------------- 274

Query: 360  ERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKG 419
                           P E  F G  S G +  PG    P  K     + +      +G  
Sbjct: 275  ---------------PGEVGFAG--SPGARGFPGAPGLPGLKGHRGHKGLEGPKGEVG-A 316

Query: 420  PGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEF 479
            PG + + G P GP G      +   + P  M  + G +GP       P Q          
Sbjct: 317  PGSKGEAG-PTGPMG------AMGPLGPRGMPGERGRLGPQG----APGQRG-------- 357

Query: 480  YEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGT----EPFS 535
                                     HG  G   GP  P  +  S G+ PG      E   
Sbjct: 358  ------------------------AHGMPG-KPGPMGPLGIPGSSGF-PGNPGMKGEAGP 391

Query: 536  DGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDD 595
             G   P    P+G       PG  +  PG  G I ++   P    P   PG SG      
Sbjct: 392  TGARGPEG--PQGQRGETGPPG-PVGSPGLPGAIGTD-GTPGAKGPTGSPGTSGPPGSAG 447

Query: 596  VPKIPDGRNFPPGQGIFSGPG-------RGER----FPNPQGL-------SEEMFQQQLA 637
             P  P  +     QGI   PG       +GE      P P G+        EE  +    
Sbjct: 448  PPGSPGPQGSTGPQGIRGQPGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGKRGPRG 507

Query: 638  EKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGI 697
            +     PPG   E   P    NR  PGS     P           +G   P     PKG 
Sbjct: 508  DPGTVGPPGPVGERGAPG---NRGFPGSDGLPGPKG--------AQGERGPVGSSGPKG- 555

Query: 698  PPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDM 757
              Q  PGR  E      G+ G   L  N G   Q    K+   GA P E  +  P GS  
Sbjct: 556  -SQGDPGRPGE-----PGLPGARGLTGNPG--VQGPEGKLGPLGA-PGEDGRPGPPGSIG 606

Query: 758  LPAQQKMVPLPFGEHPQQEYGMGPRP------FLPMSQGPGSNSGLRNLREPIGPDQRTN 811
            +  Q   + LP    P+   G   +P       +P  +G     G      P+GP     
Sbjct: 607  IRGQPGSMGLP---GPKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAG 663

Query: 812  SRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAG-----------------SQ 854
             R    PP P      P      PP   G G KP D  V G                  +
Sbjct: 664  ERGEQGPPGPTGFQGLP-----GPPGPPGEGGKPGDQGVPGDPGAVGPLGPRGERGNPGE 718

Query: 855  VHSPGINPLKSPT----MHQVQSPMLGSPSGNLKSPQT-PSQLAGMLAGPAAAASIKSPP 909
               PGI  L         H    P  GSP  +     T P  L GM  G    A    P 
Sbjct: 719  RGEPGITGLPGEKGMAGGHGPDGPK-GSPGPSGTPGDTGPPGLQGM-PGERGIAGTPGPK 776

Query: 910  ----VLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNV 965
                 +G   A        +   P P     P  P    G P        +  P   GN 
Sbjct: 777  GDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRG---LVGPPGSRGNP 833

Query: 966  ESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLY 1025
             S G   PT          G++  + P     +P +   P             P      
Sbjct: 834  GSRGENGPT----------GAVGFAGPQGPDGQPGVKGEP-----------GEPGQ---- 868

Query: 1026 HDAIKTVASSDDDSPPARSPNLPSMNNMPGM--GINTQNP-----------RISGPNPV- 1071
                K  A S      A SP     N +PG+  G  TQ P           R+  P P  
Sbjct: 869  ----KGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAG 924

Query: 1072 --VPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPM 1129
               P   L   G   P        S   VG    P G P GPG        G    + P 
Sbjct: 925  APGPAGPLGEPGKEGPPGLRGDPGSHGRVGDR-GPAGPPGGPGDKGDPGEDGQPGPDGPP 983

Query: 1130 VP------QGRMGFP-----QGFPPVQSP---PQQVPFPHNGPSGGQGSF--PGGMGFPG 1173
             P      +G +G P     +G P +  P   P +V     GP+G  G    PG +G PG
Sbjct: 984  GPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKV-----GPTGATGDKGPPGPVGPPG 1038

Query: 1174 -EGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIP 1232
              GP+G P              P GP G D       ++       D      PG+ G P
Sbjct: 1039 SNGPVGEPG-------------PEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAP 1085

Query: 1233 EFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPG-- 1290
                    P   P    Q   RG+ PG + P GP PG +  +G+ G Q PR      G  
Sbjct: 1086 ----GTPGPVGAPGDAGQ---RGD-PGSRGPIGP-PGRAGKRGLPGPQGPRGDKGDHGDR 1136

Query: 1291 --------------MGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSP 1336
                           G PGP G P+   G+A       P  PP     G +GP  +  +P
Sbjct: 1137 GDRGQKGHRGFTGLQGLPGPPG-PNGEQGSAGIPGPFGPRGPP-----GPVGPSGKEGNP 1190

Query: 1337 AQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQG-MMGPQQNIM 1395
                  G P +  +   A         GP G    PGP G PG + +  G +MG     M
Sbjct: 1191 GPLGPIGPPGVRGSVGEA------GPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDESM 1244

Query: 1396 IPP 1398
              P
Sbjct: 1245 PDP 1247



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 146/549 (26%), Positives = 185/549 (33%), Gaps = 137/549 (24%)

Query: 931  PGWTSSPKPPLQSPGIPPNHKAPLTMASP---AMLGNVESGGPPPPTASQPASVN----- 982
            PG   +P PP       P+H  P  ++ P    M G  E  G        P SV      
Sbjct: 167  PGQPGAPGPPGH-----PSHPGPDGLSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPVGPR 221

Query: 983  ----IPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDD 1038
                + G    + P   P EP     P+  + SR      P   P             +D
Sbjct: 222  GPQGLQGQQGGAGPTGPPGEPG-DPGPMGPIGSRG-----PEGPP---------GKPGED 266

Query: 1039 SPPARSPN--------------LPSMNNMPGMGINTQNPRISGPNPVVPMP-------TL 1077
              P R+ N               P    +PG+  +  +  + GP   V  P         
Sbjct: 267  GEPGRNGNPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGEVGAPGSKGEAGPT 326

Query: 1078 SPMGMTQPLSHSNQMPSPNAVGPNIPP-----HGVPMGPGLMSHNPIMGHGSQEPPMVPQ 1132
             PMG   PL           +GP   P     HG+P  PG M             P+   
Sbjct: 327  GPMGAMGPLGPRGMPGERGRLGPQGAPGQRGAHGMPGKPGPMG------------PLGIP 374

Query: 1133 GRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSF-----PGGMGFPG-EGPLGRPSNLPQS 1186
            G  GFP G P ++   +  P    GP G QG       PG +G PG  G +G        
Sbjct: 375  GSSGFP-GNPGMKG--EAGPTGARGPEGPQGQRGETGPPGPVGSPGLPGAIGTDGT---P 428

Query: 1187 SADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIR--PGATGIPEFDLSRIIPSEK 1244
             A      PG  G P S    G+  P   T P   + IR  PG  G+P F          
Sbjct: 429  GAKGPTGSPGTSGPPGSAGPPGSPGPQGSTGP---QGIRGQPGDPGVPGFKG-------- 477

Query: 1245 PSQTLQYFPRGEVPGRKQPQGP-GPGFSHMQGMMGEQAPRMGLALPG-MGGPGPVGTPDI 1302
                 +  P+GE PG    QGP GP      G  G++ PR     PG +G PGPVG    
Sbjct: 478  -----EAGPKGE-PGPHGIQGPIGP-----PGEEGKRGPRGD---PGTVGPPGPVGERGA 523

Query: 1303 PLGTAPSMPGHNPMRPPAFLQQ-----GMMGPHHRMMSPAQSTMPGQPT---LMSNPAAA 1354
            P       PG + +  P   Q      G  GP      P +   PG P    L  NP   
Sbjct: 524  PGNRG--FPGSDGLPGPKGAQGERGPVGSSGPKGSQGDPGRPGEPGLPGARGLTGNPGV- 580

Query: 1355 VGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGF 1414
                    +GP G     GP+G+PG      G  GP  +I I  Q    G+    G  G 
Sbjct: 581  --------QGPEGKL---GPLGAPGE----DGRPGPPGSIGIRGQPGSMGLPGPKGSSGD 625

Query: 1415 SQGPGNPGN 1423
               PG  GN
Sbjct: 626  PGKPGEAGN 634



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 86/299 (28%), Positives = 106/299 (35%), Gaps = 32/299 (10%)

Query: 1143 PVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPD 1202
            PV  P +  P     P GG  +F  G     +G  G P  +P  +      +PG  G P 
Sbjct: 85   PVTPPGECCPVCSQTPGGGNTNFGRGR----KGQKGEPGLVPVVTGIRG--RPGPAGPPG 138

Query: 1203 SFTVLGNSMPSVFTDPDLQEVI--RPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGR 1260
            S    G   P     P   + I   PG  G P        PS      L      ++ G 
Sbjct: 139  SQGPRGERGPKGRPGPRGPQGIDGEPGVPGQPGAPGPPGHPSHPGPDGLSRPFSAQMAGL 198

Query: 1261 KQPQGPGPGFSHMQGMMGEQAPRMGLALPGM-GGPGPVGTPDIPLGTAPSMP--GHNPMR 1317
             +  G G     M G +G   PR    L G  GG GP G P  P    P  P     P  
Sbjct: 199  DEKSGLGSQVGLMPGSVGPVGPRGPQGLQGQQGGAGPTGPPGEPGDPGPMGPIGSRGPEG 258

Query: 1318 PPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKD--RGPAGLYTHPGPV 1375
            PP   + G  G   R  +P +    G P     P A    +PG    RG  GL    G V
Sbjct: 259  PPG--KPGEDGEPGRNGNPGEVGFAGSPGARGFPGAPG--LPGLKGHRGHKGLEGPKGEV 314

Query: 1376 GSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQG----------PGNPGNM 1424
            G+PG     +G  GP   +     + PRGM  + G  G  QG          PG PG M
Sbjct: 315  GAPGS----KGEAGPTGPMGAMGPLGPRGMPGERGRLG-PQGAPGQRGAHGMPGKPGPM 368



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 149/626 (23%), Positives = 192/626 (30%), Gaps = 139/626 (22%)

Query: 235  PQQPPAPANQ--DQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSP 292
            P  PP  A +  +Q     T  Q  P  P P   P    +P D+  PG           P
Sbjct: 655  PVGPPGLAGERGEQGPPGPTGFQGLPGPPGP---PGEGGKPGDQGVPG----------DP 701

Query: 293  ASSTPLPPDGTGPNSTPNNRAVTPVS----QGSNSSSADPKAPPPPPVSSGEPPTLGENP 348
             +  PL P G   N  P  R    ++    +   +    P  P   P  SG P   G  P
Sbjct: 702  GAVGPLGPRGERGN--PGERGEPGITGLPGEKGMAGGHGPDGPKGSPGPSGTPGDTG--P 757

Query: 349  DGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSG-----GPQQNPGVLDGPQKKPE 403
             GL     E         +  +  +     E T    G     GP   PG      +K E
Sbjct: 758  PGLQGMPGERGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGE 817

Query: 404  GPIQAMMAQSQSLGKGPGPRTDVG--------APFGPQGHRDVPFSPDEMVPPSMNSQSG 455
               + ++    S G  PG R + G         P GP G   V   P E   P     +G
Sbjct: 818  PGPRGLVGPPGSRGN-PGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGE---PGQKGDAG 873

Query: 456  TIGPDHLDHMT----PEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGV- 510
            + GP  L        P  +  LK         R  Q              V   GP G  
Sbjct: 874  SPGPQGLAGSPGPHGPNGVPGLK-------GGRGTQGPPGATGFPGSAGRVGPPGPAGAP 926

Query: 511  ----------------VRGPPPPYQMTPSEGWA--PGGT----EPFSDGINMPHSLP-PR 547
                            +RG P  +      G A  PGG     +P  DG   P   P P 
Sbjct: 927  GPAGPLGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPA 986

Query: 548  GMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWP-----DDVPKIPDG 602
            G      + G    +PG  G    E   P +P PA  PG  G +          P  P G
Sbjct: 987  GTTGQRGIVG----MPGQRG----ERGMPGLPGPAGTPGKVGPTGATGDKGPPGPVGPPG 1038

Query: 603  RNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMI 662
             N P G+    GP   +  P   G         + E+     PG A             +
Sbjct: 1039 SNGPVGEPGPEGPAGNDGTPGRDG--------AVGERGDRGDPGPA------------GL 1078

Query: 663  PGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMV-PSGMKGDVN 721
            PGSQ    PG        PV  P    +   P    P   PGR  + G+  P G +GD  
Sbjct: 1079 PGSQG--APGTPG-----PVGAPGDAGQRGDPGSRGPIGPPGRAGKRGLPGPQGPRGDKG 1131

Query: 722  LNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGP 781
             + + G       QK      G + +                  P P G + +Q     P
Sbjct: 1132 DHGDRGDRG----QKGHRGFTGLQGL------------------PGPPGPNGEQGSAGIP 1169

Query: 782  RPFLPMS-QGPGSNSGLRNLREPIGP 806
             PF P    GP   SG      P+GP
Sbjct: 1170 GPFGPRGPPGPVGPSGKEGNPGPLGP 1195



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 77/342 (22%), Positives = 106/342 (30%), Gaps = 80/342 (23%)

Query: 230  DPKPLPQQPPAPANQDQN-------SSQNTRLQPTPPIPAPAPKPAAPPRPLDRESP--- 279
            D +P P  PP PA              +  R  P  P PA  P    P      + P   
Sbjct: 974  DGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGPPGP 1033

Query: 280  -GVENKLIPSVGSPASSTPLPPDGT----------------GPNSTPNNRAVT----PV- 317
             G      P VG P    P   DGT                GP   P ++       PV 
Sbjct: 1034 VGPPGSNGP-VGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPGPVG 1092

Query: 318  SQGSNSSSADP--KAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFP 375
            + G      DP  + P  PP  +G+    G  P G   ++ +H +R  +  +        
Sbjct: 1093 APGDAGQRGDPGSRGPIGPPGRAGKRGLPG--PQGPRGDKGDHGDRGDRGQKG------- 1143

Query: 376  DEKEFTGAQS----GGP--QQNPGVLDGP--QKKPEGPIQAMMAQSQSLGKGPGPRTDVG 427
              + FTG Q      GP  +Q    + GP   + P GP+            GP  +    
Sbjct: 1144 -HRGFTGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPV------------GPSGKEGNP 1190

Query: 428  APFGPQGHRDVPFSPDEMVPPSMNSQSGTIGP---------------DHLDHMTPEQIAW 472
             P GP G   V  S  E  P     + G  GP                H D   P+ +  
Sbjct: 1191 GPLGPIGPPGVRGSVGEAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDESMPDPLPE 1250

Query: 473  LKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGP 514
                Q   ++K +    V     SL   +     P G  + P
Sbjct: 1251 FTEDQAAPDDKNKTDPGVHATLKSLSSQIETMRSPDGSKKHP 1292


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 242/986 (24%), Positives = 330/986 (33%), Gaps = 171/986 (17%)

Query: 507  PRGVVRGPPPPYQMTPSEGWAPG-----GTEPFSD------GINMPHSLP---------- 545
            P G  R PPP   +TP+     G     G +P ++      G  +P S P          
Sbjct: 29   PPGSPRPPPP---VTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGT 85

Query: 546  -PRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSG-----VSWPDDVPKI 599
              R  A  P   G   R P         +  P   +  +RPG  G     +S  + V + 
Sbjct: 86   SSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR- 144

Query: 600  PDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQ-QLAEKQLGLPPGMAMEGIRPSMEM 658
                  P    + +G  R    P P   S  M ++ + A  ++GLP        RP  E 
Sbjct: 145  GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG 204

Query: 659  NRM-IPGSQRHMEPGNNPIFPRIPVEG-------PLSPSRGDFPKGIPPQMGPGRELEFG 710
             R  +  +  H     +P   R P  G         S S    P   P + GP       
Sbjct: 205  PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSAR-GTP 263

Query: 711  MVPSGMKGDVNLNVNMGSNSQMIPQKMREAGA-GPEEMLKLR---PGGSDMLPA---QQK 763
              P+         +      Q+ P +   A A GP     L    P G+   P       
Sbjct: 264  RAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNA 323

Query: 764  MVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPP-LPL 822
              PLP    P       P P  P S  P +   L+ L  P           S  PP +  
Sbjct: 324  ATPLPATLPPSPPLAT-PLPLAPPS--PSAPPSLQTLPSPPATPP------SQAPPSMTT 374

Query: 823  NPSSNPTSLNTAPPVQ-------RGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPM 875
             P   P SL T PP+Q         L   P  ++++  Q        L SPT+    S +
Sbjct: 375  PPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQ----ATTSLGSPTLQATHSFL 430

Query: 876  LGSP---SGNLKSPQTPSQLAGMLAGPAAAASI-KSPPVLGSAAASPVHLKSP----SLP 927
              SP     +L SP  P+          A  S+  SPP+  S + +   L SP     L 
Sbjct: 431  TMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQ 490

Query: 928  APSPGWTSSPKPPL----------QSPGIPPNHKAPLTMASPAMLGNVESGGPPP-PTAS 976
            A S   + SP+ PL          QS   PP+ + P    +   L N+ S  PPP  TAS
Sbjct: 491  ALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTAS 550

Query: 977  QPAS---VNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVA 1033
             P +   +  P   P+  P   PP P  +  P        S  A P   P    A+ +  
Sbjct: 551  APLTTPHLETP-PCPAPCPLQAPPSPLTTPPP-----ETPSSIATP--PPQAPPALASPP 602

Query: 1034 SSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHS---- 1089
                 SPP      P     P + +    P +  P      P LSP+    P + +    
Sbjct: 603  LQGLPSPPLSPLATPPPQAPPXLAL----PPLQAPPSPPASPPLSPLATPSPQAPNALAV 658

Query: 1090 -------NQMPSPNAVGPNIPPHGVPMGPGL---------MSHNPIMGHGS--QEPPMVP 1131
                   +  PSP    P  PP   P+ P           ++  P+    S    PPM P
Sbjct: 659  HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 718

Query: 1132 QGRMGFPQGFPPVQSPPQQVP--FPHNGPSGGQGSFPGGM-----GFPGEGPLGRPSNLP 1184
                  PQ  PP+ +PP QVP   P + P     + P  +       P + P   P++LP
Sbjct: 719  SATPP-PQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLP 777

Query: 1185 QS-------SADAALCKP---GGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEF 1234
             S        A  AL  P     P  P SF       PS            P A  +   
Sbjct: 778  MSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 837

Query: 1235 DLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGP 1294
             L ++ PS   S TLQ          ++P  PGP  S          PR+ LAL     P
Sbjct: 838  PLLQVPPSPPASPTLQ--------APRRPPTPGPDTS-------VSGPRLTLALAPGPPP 882

Query: 1295 GPVGTPDIPLGTAPSMPGH--NPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPA 1352
             P  +P   L + P + GH  +    P  L+    GP       A S  P       +PA
Sbjct: 883  PPSRSPSSTL-SGPDLAGHSSSATSTPEELRGYDSGPEG---GAAASPPPDAELAACHPA 938

Query: 1353 AAVGMIPGKDRGPAGLYTHPGPVGSP 1378
            A         RGPA      G  G+P
Sbjct: 939  A-------WSRGPAPPLAFRGAPGAP 957



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 265/1192 (22%), Positives = 373/1192 (31%), Gaps = 217/1192 (18%)

Query: 210  NNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKP-- 267
            +NK +++ A    +  A R      P+ P +P             +P PP+   A +   
Sbjct: 2    DNKRDKAKAGAAARTPAARAPGLLTPRPPGSP-------------RPPPPVTPAALRVLG 48

Query: 268  ---AAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSS 324
               A   +PL   + G+    IP     A  T          ++  N A  P + G    
Sbjct: 49   AAGAVGRKPLAERAGGIGGATIPESAPRAGPT------RSAGTSSRNPASRPPASGRGER 102

Query: 325  SADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQ 384
            +   K   P PVSS    +    P  L Q+ L      +     + R    +  + +   
Sbjct: 103  APPAKNTSPGPVSSPGRASGTTRPGPLGQKGLR-----ISAEETVARGKATEAPKRSALS 157

Query: 385  SGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDE 444
            +G  +   G   G       P  AM  +S++ G      T+VG P      R  P +   
Sbjct: 158  AGARRDTSGPTPGT------PSPAMARRSRAAG------TEVGLPRPAPSARPRPPTEGP 205

Query: 445  MVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQ 504
                S  S+  T  P       P     L+         R     +      L       
Sbjct: 206  RKSVSSASEHSTTEPSPAARRRPSAGGGLQ---------RPASRSLSSSATPLSSPARSG 256

Query: 505  HGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPG 564
               RG  R P  P Q  P    A          +  P   PPR  A            P 
Sbjct: 257  PSARGTPRAPAHPSQPKPKGLQA----------LRPPQVTPPRKDAA-----------PA 295

Query: 565  FAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNP 624
               + +S +  P+     +RP       P D    P     PP   + +          P
Sbjct: 296  LGPLSSSPLATPSPSGTKARPVP-----PPDNAATPLPATLPPSPPLAT----------P 340

Query: 625  QGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEG 684
              L+        + + L  PP        PSM    M         P +    P I V  
Sbjct: 341  LPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPM-------QAPPSLQTIPPIQVPH 393

Query: 685  PLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMK-GDVNLNVNMGSNSQMIPQKMREAGAG 743
             L+          P    P   L    + +    G   L     S   M P++ + +   
Sbjct: 394  SLTS---------PSLQAPPSPLALSSLQATTSLGSPTLQATH-SFLTMSPRQTQASLTS 443

Query: 744  PEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREP 803
            P       P   D  P Q    PL     P  +  + P    P+S  P +   L+ L   
Sbjct: 444  PSRPASTPP---DSPPLQ---APLSLPASPPLQTSLSPA-VSPLSS-PLTIHPLQALSSL 495

Query: 804  IGPDQRTNSRLSHMPPLPLNPSSNPTSLNT------APPVQRGLGRKPLDISVAGSQVHS 857
                 +       MPPL    S  P SL T       PP++      P  +  A + + +
Sbjct: 496  ASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTT 555

Query: 858  PGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAAS 917
            P +     P    +Q+P   SP      P+TPS +A     P A  ++ SPP+ G  +  
Sbjct: 556  PHLETPPCPAPCPLQAPP--SPL-TTPPPETPSSIA--TPPPQAPPALASPPLQGLPSPP 610

Query: 918  PVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQ 977
               L +P   AP         PPLQ+P  PP       +A+P+         P  P A  
Sbjct: 611  LSPLATPPPQAPPX----LALPPLQAPPSPPASPPLSPLATPS---------PQAPNALA 657

Query: 978  PASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYH--DAIKTVASS 1035
               +  P S P S P   P  P  S  P+S           PS+TP      ++      
Sbjct: 658  VHLLQAPFSPPPSPPVQAPFSPPASP-PVS-----------PSATPPSQAPPSLAAPPLQ 705

Query: 1036 DDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSP 1095
               SPPA  P  PS                + P P  P P  +P     P   ++   SP
Sbjct: 706  VPPSPPASPPMSPS----------------ATPPPQAPPPLAAPPLQVPPSPPASPPMSP 749

Query: 1096 NAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPH 1155
            +A  P       P  P L++  P+     Q PP  P      P   PP Q+PP     P 
Sbjct: 750  SATPP-------PRVPPLLAAPPL-----QVPPSPPASLPMSPLAKPPPQAPPALATPPL 797

Query: 1156 NGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVF 1215
                    S      FPG+ P    ++LP S     L  P     P     L    PS  
Sbjct: 798  QALPSPPAS------FPGQAPFSPSASLPMS----PLATPPPQAPPVLAAPLLQVPPSPP 847

Query: 1216 TDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQG--PGPGFS-H 1272
              P LQ   RP   G P+  +S       P  TL   P    P  + P     GP  + H
Sbjct: 848  ASPTLQAPRRPPTPG-PDTSVS------GPRLTLALAPGPPPPPSRSPSSTLSGPDLAGH 900

Query: 1273 MQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTA-PSMPGHNPMRPPAFLQQGMMGPHH 1331
                        G      GG      PD  L    P+     P  P AF  +G  G   
Sbjct: 901  SSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAF--RGAPG--- 955

Query: 1332 RMMSPAQSTMPGQPTLMSNPAAAVGMIP-GKDRGPAGLYTHPG---PVGSPG 1379
                   + +P  P   + P +A G+    +  GP      PG   P  SPG
Sbjct: 956  -------APLPWPPA--TGPGSADGLCTIYETEGPESATPAPGALDPGPSPG 998



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 230/1027 (22%), Positives = 331/1027 (32%), Gaps = 235/1027 (22%)

Query: 13  SGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHT 72
           +G T+S+  S +    RPP               S +G++   A  + P P  S  G  +
Sbjct: 77  AGPTRSAGTSSRNPASRPPA--------------SGRGERAPPAKNTSPGPVSSP-GRAS 121

Query: 73  PKALPGPGGSMGLKNGAGNG-AKGKGKRERSISADSFDQR------DPGTPNDDSDIKEC 125
               PGP G  GL+  A    A+GK       SA S   R       PGTP+     +  
Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181

Query: 126 NSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMA 185
            +   +       +     P+    PR S  S  + + TEP+PA +         +    
Sbjct: 182 AAGTEVGLPRPAPSARPRPPTEG--PRKSVSSASEHSTTEPSPAARRRPS-----AGGGL 234

Query: 186 NKAAEAVLKGQVETIVSFHIQNISNNKTERSTA----PLNTQISALRNDPKPLPQQPPAP 241
            + A   L      + S      S   T R+ A    P    + ALR      P++  AP
Sbjct: 235 QRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAP 294

Query: 242 ANQDQNSS-------QNTRLQPTPP-----IPAPAPKPAAPP--RPLDRESPGVENKLIP 287
           A    +SS         T+ +P PP      P PA  P +PP   PL    P       P
Sbjct: 295 ALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPS------P 348

Query: 288 SVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVS---SGEPPTL 344
           S      + P PP  T P+  P +    P+        A P     PP+    S   P+L
Sbjct: 349 SAPPSLQTLPSPP-ATPPSQAPPSMTTPPMQ-------APPSLQTIPPIQVPHSLTSPSL 400

Query: 345 GENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEG 404
              P  L          +L +L+    +  P  +      +  P+Q    L  P +    
Sbjct: 401 QAPPSPL----------ALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPAST 450

Query: 405 PIQAMMAQSQ-SLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLD 463
           P  +   Q+  SL   P  +T +     P        SP  + P    S   +  P    
Sbjct: 451 PPDSPPLQAPLSLPASPPLQTSLSPAVSPLS------SPLTIHPLQALSSLASHSP---- 500

Query: 464 HMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPS 523
                               +     +++     Q  +              PP +  PS
Sbjct: 501 --------------------QAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPS 540

Query: 524 EGWAPGGTEPFSDGINMPHSLPPRGMAPHP-NMPGSQMRLPGFAGMINSEMEGPNVPNPA 582
              AP   +  S  +  PH   P   AP P   P S +  P            P  P+  
Sbjct: 541 --LAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTP-----------PPETPSSI 587

Query: 583 SRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLG 642
           + P           P+ P     PP QG+ S P      P PQ           A   L 
Sbjct: 588 ATP----------PPQAPPALASPPLQGLPSPPLSPLATPPPQ-----------APPXLA 626

Query: 643 LPPGMAMEGIRPSMEMNRMIPGSQR-------HMEPGNNPIFPRIPVEGPLSP--SRGDF 693
           LPP  A      S  ++ +   S +       H+        P  PV+ P SP  S    
Sbjct: 627 LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 686

Query: 694 PKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPG 753
           P   PP   P         PS                           A P ++    P 
Sbjct: 687 PSATPPSQAP---------PS-------------------------LAAPPLQVPPSPPA 712

Query: 754 GSDMLPA--QQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTN 811
              M P+       P P    P Q       P  P +  P S S     R P        
Sbjct: 713 SPPMSPSATPPPQAPPPLAAPPLQV------PPSPPASPPMSPSATPPPRVP-------- 758

Query: 812 SRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQV 871
             L   PPL + P S P SL  +P     L + P     A           L +P +  +
Sbjct: 759 -PLLAAPPLQV-PPSPPASLPMSP-----LAKPPPQAPPA-----------LATPPLQAL 800

Query: 872 QSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSP 931
            SP    P    ++P +PS  A +   P A    ++PPVL    A+P+    PS PA   
Sbjct: 801 PSPPASFPG---QAPFSPS--ASLPMSPLATPPPQAPPVL----AAPLLQVPPSPPA--- 848

Query: 932 GWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSST 991
                  P LQ+P  PP      +++ P +   +  G PPPP+ S  ++++ P     S+
Sbjct: 849 ------SPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSS 902

Query: 992 PYTMPPE 998
             T  PE
Sbjct: 903 SATSTPE 909



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 149/660 (22%), Positives = 213/660 (32%), Gaps = 101/660 (15%)

Query: 819  PLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGS 878
            P P  PS      + A   + GL R         ++   P   P KS +     S    S
Sbjct: 167  PTPGTPSPAMARRSRAAGTEVGLPRP-----APSARPRPPTEGPRKSVSSASEHSTTEPS 221

Query: 879  PSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPA----PSPGWT 934
            P+   +    PS   G+    + + S  + P+   A + P    +P  PA    P P   
Sbjct: 222  PAARRR----PSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGL 277

Query: 935  SSPKPPL-------QSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSL 987
             + +PP         +P + P   +PL   SP+  G      PPP  A+ P    +P S 
Sbjct: 278  QALRPPQVTPPRKDAAPALGPLSSSPLATPSPS--GTKARPVPPPDNAATPLPATLPPSP 335

Query: 988  PSSTPYTM-PPEPTL---------------SQNPLSI----MMSRMSKFAMP-------- 1019
            P +TP  + PP P+                SQ P S+    M +  S   +P        
Sbjct: 336  PLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSL 395

Query: 1020 SSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSP 1079
            +S  L         SS   +    SP L + ++   M        ++ P+     P  SP
Sbjct: 396  TSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSP 455

Query: 1080 MGMTQPLSHSNQMPSPNAVGPNIPPHGVPMG-------PGLMSHNPIMGHGSQ-EPPMVP 1131
              +  PLS     P   ++ P + P   P+          L SH+P     S   PP+  
Sbjct: 456  -PLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLET 514

Query: 1132 QGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPS-NLPQSSADA 1190
            Q  +  P     +Q+PP  +  P   P     S           PL  P    P   A  
Sbjct: 515  QSSLAPPS----LQTPPASLTTP---PLENLPSLAPPPLQTASAPLTTPHLETPPCPAPC 567

Query: 1191 ALCKPGG------PGGPDSFTVLGNSMPSVFTDPDLQEV----IRPGATGIPEFDLSRII 1240
             L  P        P  P S        P     P LQ +    + P AT  P+      +
Sbjct: 568  PLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLAL 627

Query: 1241 PSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGP--GPVG 1298
            P  +   +    P         PQ P     H+      QAP      P +  P   P  
Sbjct: 628  PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLL-----QAPFSPPPSPPVQAPFSPPAS 682

Query: 1299 TPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMI 1358
             P  P  T PS    +   PP  LQ     P    MSP+ +  P  P  ++ P       
Sbjct: 683  PPVSPSATPPSQAPPSLAAPP--LQVPPSPPASPPMSPSATPPPQAPPPLAAPP------ 734

Query: 1359 PGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGP 1418
                     L   P P  SP M  S          +  PP   P    A + M   ++ P
Sbjct: 735  ---------LQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPP 785


>gi|18105032 type X collagen alpha 1 precursor [Homo sapiens]
          Length = 680

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 142/510 (27%), Positives = 172/510 (33%), Gaps = 91/510 (17%)

Query: 940  PLQSPGIPPNHKA----PLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTM 995
            P    G  PN K     P T+ S  +    E G P PP  + P     P   P    Y  
Sbjct: 28   PTGIKGPLPNTKTQFFIPYTIKSKGIAVRGEQGTPGPPGPAGPRGHPGPSGPPGKPGYGS 87

Query: 996  P---PEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNN 1052
            P    EP L   P    + +     +P                    P  R P  P  + 
Sbjct: 88   PGLQGEPGLPGPPGPSAVGKPGVPGLPG------------------KPGERGPYGPKGDV 129

Query: 1053 MPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPP--HGVPMG 1110
             P        PR     P +P     P G++ P     Q P+  A GP   P   G P  
Sbjct: 130  GPA---GLPGPRGPPGPPGIP----GPAGISVPGKPGQQGPT-GAPGPRGFPGEKGAPGV 181

Query: 1111 PGLMSHNPIMGHGSQEPPMVPQGRMGF--PQGFPPVQSPPQQVPFPHNGPSGGQGSFPGG 1168
            PG+      MG+G+   P    G  G   PQG      PP       NG   GQ    G 
Sbjct: 182  PGMNGQKGEMGYGAPGRP----GERGLPGPQGPTGPSGPPGVGKRGENGVP-GQPGIKGD 236

Query: 1169 MGFPGE-GPLG--RPSNLPQSSADAALCKPGGPGGPDSFTVLGN----SMPSVFTDPDLQ 1221
             GFPGE GP+G   P   P       + KPG  G P    + G       P +   P   
Sbjct: 237  RGFPGEMGPIGPPGPQGPPGERGPEGIGKPGAAGAPGQPGIPGTKGLPGAPGIAGPPGPP 296

Query: 1222 EVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPG-----PGFSHMQGM 1276
               +PG            +P  K  +     P G  PG K  QGP      PG +   G 
Sbjct: 297  GFGKPG------------LPGLKGERGPAGLPGG--PGAKGEQGPAGLPGKPGLTGPPGN 342

Query: 1277 MGEQAPRMGLALPGMGG-PGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMS 1335
            MG Q P+    +PG  G PGP G       T P+ P   P         G  G      S
Sbjct: 343  MGPQGPK---GIPGSHGLPGPKGE------TGPAGPAGYP---------GAKGERGSPGS 384

Query: 1336 PAQSTMPGQPTLMSNPAAAVGMI-PGKDRGPAGLYTHPGPVGSPGM--MMSMQGMMGPQQ 1392
              +   PG+P L   P    G+  P  D G  G    PGPVG  G   M    G  GP+ 
Sbjct: 385  DGKPGYPGKPGL-DGPKGNPGLPGPKGDPGVGGPPGLPGPVGPAGAKGMPGHNGEAGPRG 443

Query: 1393 NIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
               IP    P G     G  G    PG+PG
Sbjct: 444  APGIPGTRGPIGPPGIPGFPGSKGDPGSPG 473



 Score = 87.4 bits (215), Expect = 9e-17
 Identities = 142/530 (26%), Positives = 178/530 (33%), Gaps = 109/530 (20%)

Query: 897  AGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIP--PNHKAPL 954
            AGP        PP       SP     P LP P PG ++  KP +  PG+P  P  + P 
Sbjct: 68   AGPRGHPGPSGPPGK-PGYGSPGLQGEPGLPGP-PGPSAVGKPGV--PGLPGKPGERGPY 123

Query: 955  TM---ASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTL---SQNPLSI 1008
                   PA L     G P PP    PA +++PG  P     T  P P      +    +
Sbjct: 124  GPKGDVGPAGLPGPR-GPPGPPGIPGPAGISVPGK-PGQQGPTGAPGPRGFPGEKGAPGV 181

Query: 1009 MMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSM--NNMPGM-------GIN 1059
                  K  M    P      + +      + P+  P +     N +PG        G  
Sbjct: 182  PGMNGQKGEMGYGAP-GRPGERGLPGPQGPTGPSGPPGVGKRGENGVPGQPGIKGDRGFP 240

Query: 1060 TQNPRISGPNPVVPMPTLSPMGMTQP----------LSHSNQMP-SPNAVGPNIPP-HGV 1107
             +   I  P P  P     P G+ +P          +  +  +P +P   GP  PP  G 
Sbjct: 241  GEMGPIGPPGPQGPPGERGPEGIGKPGAAGAPGQPGIPGTKGLPGAPGIAGPPGPPGFGK 300

Query: 1108 PMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPG 1167
            P  PGL       G          QG  G P G P +  PP  +     GP G +G  PG
Sbjct: 301  PGLPGLKGERGPAGLPGGPGAKGEQGPAGLP-GKPGLTGPPGNM-----GPQGPKG-IPG 353

Query: 1168 GMGFPGE-------GPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDL 1220
              G PG        GP G P    +  +  +  KPG PG P      GN        P L
Sbjct: 354  SHGLPGPKGETGPAGPAGYPGAKGERGSPGSDGKPGYPGKPGLDGPKGN--------PGL 405

Query: 1221 QEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQ 1280
                 PG  G P                      G  PG   P GP  G   M G  GE 
Sbjct: 406  -----PGPKGDPGV--------------------GGPPGLPGPVGPA-GAKGMPGHNGEA 439

Query: 1281 APRMGLALPGMGGP-GPVGTPDIPLGTA-PSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQ 1338
             PR    +PG  GP GP G P  P     P  PG  P  P     +G+ GP         
Sbjct: 440  GPRGAPGIPGTRGPIGPPGIPGFPGSKGDPGSPG--PPGPAGIATKGLNGP--------- 488

Query: 1339 STMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMM 1388
            +  PG P             P    G  GL   PGP G PG  +  +G +
Sbjct: 489  TGPPGPPG------------PRGHSGEPGLPGPPGPPGPPGQAVMPEGFI 526



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 149/527 (28%), Positives = 189/527 (35%), Gaps = 102/527 (19%)

Query: 932  GWTSSPKPPLQSPGIPPNHKAPLT------MASPAMLGNVESGGPPPPTA-SQPASVNIP 984
            G   +P PP   P  P  H  P          SP + G     GPP P+A  +P    +P
Sbjct: 57   GEQGTPGPP--GPAGPRGHPGPSGPPGKPGYGSPGLQGEPGLPGPPGPSAVGKPGVPGLP 114

Query: 985  GSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARS 1044
            G      PY     P     P  +   R      P    +   A  +V        P  +
Sbjct: 115  GKPGERGPYG----PKGDVGPAGLPGPR----GPPGPPGIPGPAGISVPGKPGQQGPTGA 166

Query: 1045 PN---LPSMNNMPGM-GINTQNPRISGPNPVVP----MPTLSPMGMTQPLSHSNQMPSPN 1096
            P     P     PG+ G+N Q   +    P  P    +P   P G T P         P 
Sbjct: 167  PGPRGFPGEKGAPGVPGMNGQKGEMGYGAPGRPGERGLP--GPQGPTGP-------SGPP 217

Query: 1097 AVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHN 1156
             VG     +GVP  PG+       G   +  P+ P G    PQG PP +  P+ +  P  
Sbjct: 218  GVGKR-GENGVPGQPGIKGDR---GFPGEMGPIGPPG----PQG-PPGERGPEGIGKPGA 268

Query: 1157 GPSGGQGSFPGGMGFPG----EGPLGRPS----NLPQSSADAALC-KPGGPGGPDSFTVL 1207
              + GQ   PG  G PG     GP G P      LP    +      PGGPG        
Sbjct: 269  AGAPGQPGIPGTKGLPGAPGIAGPPGPPGFGKPGLPGLKGERGPAGLPGGPGAKGEQGPA 328

Query: 1208 GNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQG-P 1266
            G       T P    +   G  GIP    S  +P  K  +T    P G  PG K  +G P
Sbjct: 329  GLPGKPGLTGPP-GNMGPQGPKGIPG---SHGLPGPK-GETGPAGPAG-YPGAKGERGSP 382

Query: 1267 G----PGFSHMQGMMGEQAPRMGLALPG-MGGPGPVGTPDIPLGTAPS----MPGHNPMR 1317
            G    PG+    G+ G   P+    LPG  G PG  G P +P    P+    MPGHN   
Sbjct: 383  GSDGKPGYPGKPGLDG---PKGNPGLPGPKGDPGVGGPPGLPGPVGPAGAKGMPGHNGEA 439

Query: 1318 PPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTH--PGPV 1375
             P     G+ G    +  P    +PG P    +P +     PG   GPAG+ T    GP 
Sbjct: 440  GPRG-APGIPGTRGPIGPPG---IPGFPGSKGDPGS-----PGPP-GPAGIATKGLNGPT 489

Query: 1376 GSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPG 1422
            G PG                 PP   PRG + + G+ G    PG PG
Sbjct: 490  GPPG-----------------PP--GPRGHSGEPGLPGPPGPPGPPG 517



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 124/457 (27%), Positives = 157/457 (34%), Gaps = 117/457 (25%)

Query: 505 HGPRGVV--------RGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLP-PRGMAPHPNM 555
           +GP+G V        RGPP P    P      G + P   G   P   P PRG       
Sbjct: 123 YGPKGDVGPAGLPGPRGPPGP----PGIPGPAGISVPGKPGQQGPTGAPGPRGFPGEKGA 178

Query: 556 PGSQMRLPGFAGMINSEMEG-PNVPNPASRPGLSGVSWPDDVPK--------------IP 600
           PG    +PG  G       G P  P     PG  G + P   P               I 
Sbjct: 179 PG----VPGMNGQKGEMGYGAPGRPGERGLPGPQGPTGPSGPPGVGKRGENGVPGQPGIK 234

Query: 601 DGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNR 660
             R FP   G    PG       PQG   E   + + +      PG A    +P +   +
Sbjct: 235 GDRGFPGEMGPIGPPG-------PQGPPGERGPEGIGK------PGAAGAPGQPGIPGTK 281

Query: 661 MIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDV 720
            +PG+     P   P F +  + G L   RG  P G+P   GPG + E G  P+G+ G  
Sbjct: 282 GLPGAPGIAGPPGPPGFGKPGLPG-LKGERG--PAGLPG--GPGAKGEQG--PAGLPGKP 334

Query: 721 NLN---VNMG-------SNSQMIPQKMREAG-AGPEEMLKLRPG--------GSDMLPAQ 761
            L     NMG         S  +P    E G AGP       PG        GSD  P  
Sbjct: 335 GLTGPPGNMGPQGPKGIPGSHGLPGPKGETGPAGPAGY----PGAKGERGSPGSDGKPGY 390

Query: 762 QKMVPL------PFGEHPQQEYGMGPRPFLPMSQG-------PGSNS--------GLRNL 800
                L      P    P+ + G+G  P LP   G       PG N         G+   
Sbjct: 391 PGKPGLDGPKGNPGLPGPKGDPGVGGPPGLPGPVGPAGAKGMPGHNGEAGPRGAPGIPGT 450

Query: 801 REPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVA-----GSQV 855
           R PIGP           P +P  P S     +  PP   G+  K L+         G + 
Sbjct: 451 RGPIGP-----------PGIPGFPGSKGDPGSPGPPGPAGIATKGLNGPTGPPGPPGPRG 499

Query: 856 HS--PGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPS 890
           HS  PG+     P     Q+ M   P G +K+ Q PS
Sbjct: 500 HSGEPGLPGPPGPPGPPGQAVM---PEGFIKAGQRPS 533



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 118/505 (23%), Positives = 163/505 (32%), Gaps = 117/505 (23%)

Query: 255 QPTPPIPAPA-----PKPAAPPRPLDRESPGVENKLIPSV-GSPASSTPLPPDGTGPNST 308
           Q TP  P PA     P P+ PP      SPG++ +  P + G P  S    P   G    
Sbjct: 59  QGTPGPPGPAGPRGHPGPSGPPGKPGYGSPGLQGE--PGLPGPPGPSAVGKPGVPGLPGK 116

Query: 309 PNNRA-VTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLR 367
           P  R    P      +    P+ PP PP   G P   G +  G   +Q            
Sbjct: 117 PGERGPYGPKGDVGPAGLPGPRGPPGPP---GIPGPAGISVPGKPGQQ------------ 161

Query: 368 DIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKG-PGPRTDV 426
                              GP   PG    P +K    +  M  Q   +G G PG   + 
Sbjct: 162 -------------------GPTGAPGPRGFPGEKGAPGVPGMNGQKGEMGYGAPGRPGER 202

Query: 427 GAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHL--DHMTPEQIAWLKLQQEFYEEKR 484
           G P GPQG    P  P          ++G  G   +  D   P ++  +           
Sbjct: 203 GLP-GPQG----PTGPSGPPGVGKRGENGVPGQPGIKGDRGFPGEMGPIGPPGPQGPPGE 257

Query: 485 RKQEQVVVQQCSLQDMMVHQHGPRGV-----VRGPPPPYQMTPSEGWAPGGTEPFSDGIN 539
           R  E +     +         G +G+     + GPP P          PG  +P   G+ 
Sbjct: 258 RGPEGIGKPGAAGAPGQPGIPGTKGLPGAPGIAGPPGP----------PGFGKPGLPGLK 307

Query: 540 MPHSLPPRGMAPHPNMPGSQ--MRLPGFAGMI----NSEMEGP-NVPNPASRPGLSGVSW 592
                 P G+   P   G Q    LPG  G+     N   +GP  +P     PG  G + 
Sbjct: 308 GERG--PAGLPGGPGAKGEQGPAGLPGKPGLTGPPGNMGPQGPKGIPGSHGLPGPKGETG 365

Query: 593 PDDVPKIP-----------DGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQL 641
           P      P           DG+   PG+    GP      P P+G           +  +
Sbjct: 366 PAGPAGYPGAKGERGSPGSDGKPGYPGKPGLDGPKGNPGLPGPKG-----------DPGV 414

Query: 642 GLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSP--------SRGDF 693
           G PPG+    + P+    + +PG      P   P  P     GP+ P        S+GD 
Sbjct: 415 GGPPGLP-GPVGPAGA--KGMPGHNGEAGPRGAPGIP--GTRGPIGPPGIPGFPGSKGD- 468

Query: 694 PKGIPPQMGPGRELEFGMVPSGMKG 718
             G P   GP      G+   G+ G
Sbjct: 469 -PGSPGPPGPA-----GIATKGLNG 487



 Score = 34.7 bits (78), Expect = 0.67
 Identities = 72/297 (24%), Positives = 92/297 (30%), Gaps = 80/297 (26%)

Query: 231 PKPLPQQPPAPANQDQNSSQNTRLQPTPPIPA----PAPK----PAAPPRPLDRESPGVE 282
           P+  P +  AP     N  +       P  P     P P+    P+ PP    R   GV 
Sbjct: 169 PRGFPGEKGAPGVPGMNGQKGEMGYGAPGRPGERGLPGPQGPTGPSGPPGVGKRGENGVP 228

Query: 283 NKLIPSV----GSPASSTPLPPDGTGPNSTPNNR----------AVTPVSQGSNSSSADP 328
            +  P +    G P    P+ P G  P   P  R          A  P   G   +   P
Sbjct: 229 GQ--PGIKGDRGFPGEMGPIGPPG--PQGPPGERGPEGIGKPGAAGAPGQPGIPGTKGLP 284

Query: 329 KAP----PPPPVSSGEPPTLG----ENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEF 380
            AP    PP P   G+P   G      P GL        E+    L        P +   
Sbjct: 285 GAPGIAGPPGPPGFGKPGLPGLKGERGPAGLPGGPGAKGEQGPAGL--------PGKPGL 336

Query: 381 TGAQSG-GPQQNPGV-----LDGPQKK--PEGPIQAMMAQSQSLGKG------------- 419
           TG     GPQ   G+     L GP+ +  P GP     A+ +    G             
Sbjct: 337 TGPPGNMGPQGPKGIPGSHGLPGPKGETGPAGPAGYPGAKGERGSPGSDGKPGYPGKPGL 396

Query: 420 ---------PGPRTDVGA--------PFGPQGHRDVPFSPDEMVPPSMNSQSGTIGP 459
                    PGP+ D G         P GP G + +P    E  P       GT GP
Sbjct: 397 DGPKGNPGLPGPKGDPGVGGPPGLPGPVGPAGAKGMPGHNGEAGPRGAPGIPGTRGP 453


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 90.9 bits (224), Expect = 8e-18
 Identities = 173/691 (25%), Positives = 242/691 (35%), Gaps = 131/691 (18%)

Query: 818  PPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQ-----VHSPGI-NPLKSPTMHQV 871
            P  P+   S+P S     PV+     +   +S  GS+      HSP   +P  +PT   V
Sbjct: 817  PDTPIGNLSSPVS-----PVEASFLPEN-SLSFQGSKDSPATTHSPTPPSPKGAPTPSAV 870

Query: 872  QSPMLGSPSGNLKSPQ---TPS--QLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSL 926
             +P+  SP G    P+   TPS   L     GPA  A  K  P L   ++SP   K+ + 
Sbjct: 871  -TPL--SPKGVTLPPKETPTPSVVNLPFPKEGPATPAP-KQAPALSMTSSSP--KKARAT 924

Query: 927  PAP-----SPGWTSSPKPPLQSPGIP------PNHK---APLTMASPAMLGNVES----G 968
            PAP     SP    +P PP  +P  P      P+ K    P     P+  G   +    G
Sbjct: 925  PAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKG 984

Query: 969  GPPPPTASQPASVNIPGSLPS-----STPYTMPPEPTLSQNPLSI--------MMSRMSK 1015
             P PP A+ P+    P + PS     + P   PP P  S                +  S 
Sbjct: 985  APTPPAATPPSPKGGPAT-PSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSP 1043

Query: 1016 FAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMP 1075
               P++TPL   A  T A++     P   P  PS+   P        P  + P+P     
Sbjct: 1044 KGSPAATPLPKGAPTTPAATLPS--PKGGPATPSLKGAP------TPPAATPPSPKGGPA 1095

Query: 1076 TLSPMGMTQPLSHSNQMPSPNAVGPNIPPH-GVPMGPGLMSHNPIMGHGSQEP------- 1127
            T SP G   P+  +   PSP   G   PPH G P  P     +P  G  +  P       
Sbjct: 1096 TPSPKG--APMPPAATPPSPKG-GLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTP 1152

Query: 1128 ---PMVPQGRMGF--PQGFP--PVQSPPQ-----QVPFPHNGPSGGQGSFP---GGMGFP 1172
               P  P+G +    P+G P  P  +PP        P P   P+    + P   GG+  P
Sbjct: 1153 AATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATP 1212

Query: 1173 G---------------EGPLGRPSNLPQSSADAALCKPGGP-GGPDSFTVLGNSMPSVFT 1216
                            +G L  PS  P+ +       P  P GGP +    G   P   T
Sbjct: 1213 SPKGAPTTPAATPPSPKGGLATPS--PKGAPTTPAATPPSPKGGPATPPPKGAPTPPAAT 1270

Query: 1217 DPDLQ-EVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRG---EVPGRKQPQGPGPGFSH 1272
             P L+  +  P   G P            P+      P+G     P +  P  P      
Sbjct: 1271 PPSLKGGLATPPHKGAP-----------NPAVVTPPSPKGGPATSPPKGAPTPPAATPPS 1319

Query: 1273 MQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHR 1332
             +G  G   P+     P +  P P GTP +P  T PS  G  P  P         GP   
Sbjct: 1320 PKGSPGTPPPKGAPTPPAVTPPSPKGTPTLP-ATTPSSKG-GPTTP-----SSKEGPTPP 1372

Query: 1333 MMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQ 1392
              +P+    P           A+    G    PA +     P  +P   ++ +G   P +
Sbjct: 1373 AATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPL--SPKKAPATPVTREGAATPSK 1430

Query: 1393 NIMIPPQMRPRGMAADVGMGGFSQGPGNPGN 1423
              + PP + P  +           GP  P +
Sbjct: 1431 GDLTPPAVTPVSLKKAPATSAPKGGPATPSS 1461



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 304/1320 (23%), Positives = 411/1320 (31%), Gaps = 299/1320 (22%)

Query: 165  EPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQI 224
            +P   +  P+ V+  F T+   +   A L+G                      AP +   
Sbjct: 511  DPEDLKNLPSSVLVKFPTQKDLQTVPASLEG----------------------APFSPAQ 548

Query: 225  SAL--RNDPKPLPQQPPAPANQDQNSSQNTRLQ-PTPPIPAPAPKPAAPPRPLDRESPGV 281
            + L  + DP  LP    AP N     S ++  + P  P    A K    P P+ + +  +
Sbjct: 549  AGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSM 608

Query: 282  ENKLIPSVGSPAS----STPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVS 337
             + L   V S AS     +   PD  GP     +  +TP        SADP    P    
Sbjct: 609  TSPL--GVNSSASVIKTDSYAGPDSAGP--LLKSSLITPTVAAFPLESADPAGVAPTTAK 664

Query: 338  SGEPPTLGENPD-----GLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNP 392
                 T   +P       L+ +    +E +L TL      L P   E     +  PQ   
Sbjct: 665  GTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLP-----LVPTASENCPV-APSPQNTC 718

Query: 393  GVLDGPQKKPEGPIQAMMAQSQSLGKGPG-----------------------PRTDVGAP 429
              L      PE P           G  PG                       P  D GA 
Sbjct: 719  APLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGAS 778

Query: 430  FGPQGHRDVPFSPDEMVPPSMN---------SQSGTIGPDHLDHMTPEQIAWLKLQQEFY 480
                    + +  D   P  ++         ++ G+ GPD     TP  I  L       
Sbjct: 779  ATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPD-----TP--IGNLSSPVSPV 831

Query: 481  EEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINM 540
            E     +  +  Q         H   P    +G P P  +TP    +P G          
Sbjct: 832  EASFLPENSLSFQGSKDSPATTHSPTPPSP-KGAPTPSAVTPL---SPKGV--------- 878

Query: 541  PHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIP 600
              +LPP+   P P++    + LP          EGP  P P   P LS  S         
Sbjct: 879  --TLPPKE-TPTPSV----VNLP-------FPKEGPATPAPKQAPALSMTS--------- 915

Query: 601  DGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNR 660
                        S P +    P P+G+      +         PP        PS +   
Sbjct: 916  ------------SSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAP 963

Query: 661  MIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIP---------PQMGP------GR 705
              P +            P  P  GP +PS    PKG P         P+ GP      G 
Sbjct: 964  TPPAAT-----------PPSPKGGPATPS----PKGAPTPPAATPPSPKGGPATPSPKGA 1008

Query: 706  ELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMV 765
                 + P   KG           +   P     +  G      L P G+   PA    +
Sbjct: 1009 PTPPAVTPPSPKGS-PAATPFPKGASTPPAATPPSPKGSPAATPL-PKGAPTTPA--ATL 1064

Query: 766  PLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPS 825
            P P G          P P  P +  P    G      P  P  +     + MPP    PS
Sbjct: 1065 PSPKGGPATPSLKGAPTP--PAATPPSPKGG------PATPSPKG----APMPPAATPPS 1112

Query: 826  SNPTSLNTAPPVQRGLGRKPLDI--SVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNL 883
                    A P  +G    P     S  G     P   P  +PT      P   SP G L
Sbjct: 1113 PKG---GLATPPHKGAPTTPAATPPSPKGGLATPP---PKGAPTTPAATPP---SPKGGL 1163

Query: 884  KSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSP----GWTSSPKP 939
             +P       G    PAA     +PP      A+P    +P+ PA +P    G  ++P P
Sbjct: 1164 ATPPP----KGAPTTPAA-----TPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSP 1214

Query: 940  ---PLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMP 996
               P      PP+ K  L   SP        G P  P A+ P+        P   P T P
Sbjct: 1215 KGAPTTPAATPPSPKGGLATPSP-------KGAPTTPAATPPS--------PKGGPATPP 1259

Query: 997  PE--PTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVAS---SDDDSPPARSPNLPSMN 1051
            P+  PT    P +   S     A P      + A+ T  S       SPP  +P  P+  
Sbjct: 1260 PKGAPT---PPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAAT 1316

Query: 1052 NMPGMGINTQNPRISGPNPVVPMPTLSPMG-----MTQPLSHSNQMPSPNAVGPNIPPHG 1106
                 G     P    P P    P  SP G      T P S        +  GP  PP  
Sbjct: 1317 PPSPKGSPGTPPPKGAPTPPAVTPP-SPKGTPTLPATTPSSKGGPTTPSSKEGPT-PPAA 1374

Query: 1107 VPM---GPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPF-PHNGPSGGQ 1162
             P    GP +   +P  G      P +P      P+G P   + P  +P  P   P+   
Sbjct: 1375 TPSHKGGPAMTPPSPKRG------PAIPS-----PKGDP---TSPAVIPLSPKKAPA--T 1418

Query: 1163 GSFPGGMGFPGEGPLGRPSNLPQS--SADAALCKPGGPGGPDSF---TVLGNSMPSVFTD 1217
                 G   P +G L  P+  P S   A A     GGP  P S    T+   + PS    
Sbjct: 1419 PVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEP 1478

Query: 1218 PDLQEV----------IRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVP----GRKQP 1263
            P  ++V            P   G P   L  +IPS             EVP     R+ P
Sbjct: 1479 PAPKQVATSSSPKKAPATPAPMGAP--TLPAVIPSSPK----------EVPATPSSRRDP 1526

Query: 1264 QGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPL-GTAPSMP-GHNPMRPPAF 1321
              P       +      AP+  L  P M  P P  TP IP    AP+ P       PPA 
Sbjct: 1527 IAPTATLLSKK-TPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAV 1585

Query: 1322 ---LQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSP 1378
                 +G   P   ++ PA ++    P+    P       P  ++GPA     P P G+P
Sbjct: 1586 TPSTYKGAPSPKELLIPPAVTS----PSPKEAPTPPAVTPPSPEKGPA----TPAPKGTP 1637



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 248/1176 (21%), Positives = 357/1176 (30%), Gaps = 216/1176 (18%)

Query: 240  APANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLP 299
            AP N        T L   P +P  +      P P +  +P     L P +     S  LP
Sbjct: 684  APKNHPVKEGTLTTL---PLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLP 740

Query: 300  PDGTGPNSTP-----NNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQE 354
            P GT P +       +  A+ PV+        +         S G    L ++P  L   
Sbjct: 741  PAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVS 800

Query: 355  QLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQ 414
                   S QT R       P +K      S GP    G L  P      P++A      
Sbjct: 801  V------SPQTKRP------PTKKG-----SAGPDTPIGNLSSPVS----PVEASFLPEN 839

Query: 415  SLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAW-- 472
            SL                QG +D P +     PPS     G   P  +  ++P+ +    
Sbjct: 840  SLSF--------------QGSKDSPATTHSPTPPS---PKGAPTPSAVTPLSPKGVTLPP 882

Query: 473  ----------LKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTP 522
                      L   +E       KQ   +    S          P+G+   P P    TP
Sbjct: 883  KETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTP 942

Query: 523  SEGWAP----GGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNV 578
                 P    G   P       P +  P      P  P  +      A    S   GP  
Sbjct: 943  PAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPAT 1002

Query: 579  PNPASRPGLSGVSWPDD-----VPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQ 633
            P+P   P    V+ P           P G + PP     S  G     P P+G       
Sbjct: 1003 PSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAA 1062

Query: 634  QQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDF 693
               + K  G P   +++G                   P      P  P  GP +PS    
Sbjct: 1063 TLPSPK--GGPATPSLKGA------------------PTPPAATPPSPKGGPATPS---- 1098

Query: 694  PKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMI---PQKMREAGAGPEEMLKL 750
            PKG P  M P         P   KG +    + G+ +      P         P +    
Sbjct: 1099 PKGAP--MPPAA------TPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPT 1150

Query: 751  RPGGSDMLPAQQKMVPLPFGEH-------PQQEYGMGP-----RPFLPMSQGPGSNSGLR 798
             P  +   P      P P G         P  + G+        P  P +  P    GL 
Sbjct: 1151 TPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLA 1210

Query: 799  NLREPIGPDQRTNSRLSHMPPLPL------NPSSNPTSLNTAPPVQRGLGRKPLDISVAG 852
                   P     +     PP P       +P   PT+    PP  +G    P       
Sbjct: 1211 TPSPKGAPTTPAAT-----PPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPT 1265

Query: 853  SQVHSPGI--NPLKSPTMHQVQSPMLGSP----SGNLKSPQTPSQLAGMLAGPAAAASIK 906
                +P      L +P      +P + +P     G   SP   +        P+   S  
Sbjct: 1266 PPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPG 1325

Query: 907  SPPVLGS----AAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAML 962
            +PP  G+    A   P    +P+LPA +P     P  P    G  P    P     PAM 
Sbjct: 1326 TPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMT 1385

Query: 963  GNVESGGPPPPT----ASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAM 1018
                  GP  P+     + PA + +      +TP T     T S+  L+           
Sbjct: 1386 PPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLT----------P 1435

Query: 1019 PSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLS 1078
            P+ TP+      ++  +   S P   P  PS    P +      P ++ P+P  P    +
Sbjct: 1436 PAVTPV------SLKKAPATSAPKGGPATPSSKGDPTL------PAVTPPSPKEPP---A 1480

Query: 1079 PMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRM--- 1135
            P  +    S      +P  +G    P  +P  P  +   P     S+  P+ P   +   
Sbjct: 1481 PKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATP----SSRRDPIAPTATLLSK 1536

Query: 1136 GFPQGFPPVQS---PPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAAL 1192
              P    P ++   P   VP P   P+         +  P E P   PS+  ++S+  A+
Sbjct: 1537 KTPATLAPKEALIPPAMTVPSPKKTPA---------IPTPKEAP-ATPSS-KEASSPPAV 1585

Query: 1193 CKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYF 1252
                  G P    +L   +P   T P  +E   P A   P  +     P+ K + T    
Sbjct: 1586 TPSTYKGAPSPKELL---IPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSP-- 1640

Query: 1253 PRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGG----------PGPVGTPDI 1302
            P      +  P  P    + +   MG   P+    LP   G          P P  TP I
Sbjct: 1641 PVTPSSLKDSPTSP----ASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPII 1696

Query: 1303 PLGTAPSMPGHN---------PMRPPAFLQQGMMGP 1329
               TAP+  G           P+ P    + G  GP
Sbjct: 1697 ---TAPTRKGPQTKKSSATSPPICPDPSAKNGSKGP 1729



 Score = 84.3 bits (207), Expect = 7e-16
 Identities = 260/1206 (21%), Positives = 386/1206 (32%), Gaps = 219/1206 (18%)

Query: 5    NPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPC 64
            +PK   +PS  T  SPK    V + P    +PS    ++  F  +G    +  Q+ P+  
Sbjct: 860  SPKGAPTPSAVTPLSPKG---VTLPPKETPTPS---VVNLPFPKEGPATPAPKQA-PALS 912

Query: 65   DSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDIKE 124
             + S     +A P P        G       KG      +     +  P TP+     K 
Sbjct: 913  MTSSSPKKARATPAP-------KGIPASPSPKGAPTPPAATPPSPKGGPATPSP----KW 961

Query: 125  CNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEM 184
              +         +  P + +P  A  P ++TP   +     P+P +  P        +  
Sbjct: 962  APTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSP-KGAPTPPAVTPPSPK 1020

Query: 185  ANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPA--PA 242
             + AA    KG               +    +T P      A    PK  P  P A  P+
Sbjct: 1021 GSPAATPFPKGA--------------STPPAATPPSPKGSPAATPLPKGAPTTPAATLPS 1066

Query: 243  NQDQNSSQNTRLQPTPPIPAP--------APKPAAPPRPLDRESPGVENKLI--PSVGSP 292
             +   ++ + +  PTPP   P         P P   P P     P  +  L   P  G+P
Sbjct: 1067 PKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAP 1126

Query: 293  ASSTPLPPDGTG------PNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLG- 345
             +    PP   G      P   P   A TP S     ++  PK  P  P ++   P  G 
Sbjct: 1127 TTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGL 1186

Query: 346  --ENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPE 403
               +P G               L        P  K      +  P    G L  P   P+
Sbjct: 1187 ATPSPKGAPTTPAATPPSPKGGLAT------PSPKGAPTTPAATPPSPKGGLATPS--PK 1238

Query: 404  GPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLD 463
            G      A   S   GP      GAP           +P    PPS+  + G   P H  
Sbjct: 1239 GAPTTPAATPPSPKGGPATPPPKGAP-----------TPPAATPPSL--KGGLATPPHKG 1285

Query: 464  HMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPS 523
               P                                 +V    P+G     PP    TP 
Sbjct: 1286 APNPA--------------------------------VVTPPSPKGGPATSPPKGAPTP- 1312

Query: 524  EGWAPGGTEPFSDGINMPHSLPPRGMAPHPNM-PGSQMRLPGFAGMINSEMEGPNVPNPA 582
                P  T P   G   P + PP+G    P + P S    P       S   GP  P+  
Sbjct: 1313 ----PAATPPSPKG--SPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSK 1366

Query: 583  SRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLG 642
              P     + P   P    G    P       P RG   P+P+G                
Sbjct: 1367 EGP-----TPPAATPSHKGGPAMTP-----PSPKRGPAIPSPKG---------------- 1400

Query: 643  LPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDF-PKGIPP-- 699
                   +   P++     IP     + P   P  P +  EG  +PS+GD  P  + P  
Sbjct: 1401 -------DPTSPAV-----IP-----LSPKKAPATP-VTREGAATPSKGDLTPPAVTPVS 1442

Query: 700  -QMGPGRELEFG--MVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPG--G 754
             +  P      G    PS  KGD  L      + +  P   + A +   +     P   G
Sbjct: 1443 LKKAPATSAPKGGPATPSS-KGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMG 1501

Query: 755  SDMLPAQQKMVPLPFGEHPQQEYG-MGPRPFLPMSQGPGSNSGLRNLREPIG--PDQRTN 811
            +  LPA     P      P      + P   L   + P + +    L  P    P  +  
Sbjct: 1502 APTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKT 1561

Query: 812  SRLSHMPPLPLNPSSNPTSLNTA--PPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMH 869
              +      P  PSS   S   A  P   +G    P ++ +  + V SP  +P ++PT  
Sbjct: 1562 PAIPTPKEAPATPSSKEASSPPAVTPSTYKG-APSPKELLIPPA-VTSP--SPKEAPTPP 1617

Query: 870  QVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAP 929
             V  P   SP    K P TP+      + P   +S+K  P   ++ AS       ++P  
Sbjct: 1618 AVTPP---SPE---KGPATPAPKGTPTSPPVTPSSLKDSP---TSPASVTCKMGATVPQA 1668

Query: 930  SPGWTSSPKPP-LQSPGIPPNHKAPLTMASPAMLG--NVESGGPPPPTASQPASVN-IPG 985
            S G  +   P  L+   + P  ++   + +P   G    +S    PP    P++ N   G
Sbjct: 1669 SKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKG 1728

Query: 986  SLPSSTPYTMPP---EPTLSQNPLSIMMSRMSKFAMP---SSTPLYHDAIKTVASSDDDS 1039
             L +  P  + P   + + +        S     A P   +STPL   A + V    + +
Sbjct: 1729 PLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESA 1788

Query: 1040 PPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVG 1099
              + +P+                P +S P    P+PTL P     P S    + SP+   
Sbjct: 1789 SVSAAPS----------------PPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSK-- 1830

Query: 1100 PNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFP-PVQSPPQQVPFPHNGP 1158
            P  P     + P L+   PI G    +  +V    M  P+    PV +P  + P   N  
Sbjct: 1831 PLAPADEDELLP-LIPPEPISGGVPFQSVLV---NMPTPKSAGIPVPTPSAKQPVTKNNK 1886

Query: 1159 SGGQGS 1164
              G  S
Sbjct: 1887 GSGTES 1892



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 231/1039 (22%), Positives = 343/1039 (33%), Gaps = 164/1039 (15%)

Query: 5    NPKVRSSPSGNTQSSPKS-----KQEVMVRPPTVM--SPSGNPQLDSKFSNQGKQGGSA- 56
            +PK   +P   T  SPK        +    PP V   SP G+P      +    +G S  
Sbjct: 981  SPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPA-----ATPFPKGASTP 1035

Query: 57   -SQSQPSPCDSKSGGHTPKALPG-PGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPG 114
             + + PSP  S +    PK  P  P  ++    G       KG      +     +  P 
Sbjct: 1036 PAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPA 1095

Query: 115  TPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTP-AQKTP 173
            TP+         +            PH   P   T P ++ PS     AT P   A  TP
Sbjct: 1096 TPSPKGAPMPPAATPPSPKGGLATPPHKGAP---TTPAATPPSPKGGLATPPPKGAPTTP 1152

Query: 174  AKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKP 233
            A         +A    +        T  S      + +     T P  T  S       P
Sbjct: 1153 AATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATP 1212

Query: 234  LPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPA 293
             P+  P        S +     P+P   AP    A PP P  +  P       P  G+P 
Sbjct: 1213 SPKGAPTTPAATPPSPKGGLATPSPK-GAPTTPAATPPSP--KGGPATP----PPKGAPT 1265

Query: 294  SSTPLPPDGTGPNSTP------NNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGEN 347
                 PP   G  +TP      N   VTP S     +++ PK  P PP ++  PP+    
Sbjct: 1266 PPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAAT--PPS---- 1319

Query: 348  PDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQ 407
            P G           +   +        P     T +  GGP   P   +GP      P  
Sbjct: 1320 PKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPT-TPSSKEGPTPPAATPSH 1378

Query: 408  ----AMMAQSQSLGKG-PGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHL 462
                AM   S   G   P P+ D  +P        +P SP +  P +  ++ G   P   
Sbjct: 1379 KGGPAMTPPSPKRGPAIPSPKGDPTSP------AVIPLSPKK-APATPVTREGAATPSKG 1431

Query: 463  DHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTP 522
            D +TP  +  + L++       +        +       V    P+     PP P Q+  
Sbjct: 1432 D-LTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKE----PPAPKQVAT 1486

Query: 523  SEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMR-LPGFAGMINSEMEGPNVPNP 581
            S         P   G     ++ P      P  P S+   +   A +++ +      P  
Sbjct: 1487 SSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKE 1546

Query: 582  ASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQL 641
            A  P    V  P   P IP  +  P      + P   E   +P  ++   ++   + K+L
Sbjct: 1547 ALIPPAMTVPSPKKTPAIPTPKEAP------ATPSSKEA-SSPPAVTPSTYKGAPSPKEL 1599

Query: 642  GLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIP--P 699
             +PP +     + +               P    + P  P +GP +P+    PKG P  P
Sbjct: 1600 LIPPAVTSPSPKEA---------------PTPPAVTPPSPEKGPATPA----PKGTPTSP 1640

Query: 700  QMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLP 759
             + P    +    P+ +   +   V   S    +P K      GP  + ++    +   P
Sbjct: 1641 PVTPSSLKDSPTSPASVTCKMGATVPQASKG--LPAKK-----GPTALKEVLVAPA---P 1690

Query: 760  AQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPP 819
                ++  P  + PQ +      P  P+   P + +G +      GP       LS + P
Sbjct: 1691 ESTPIITAPTRKGPQTKKSSATSP--PICPDPSAKNGSK------GP-------LSTVAP 1735

Query: 820  LPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSP 879
             PL P    +S             K  D S      HSP     K P         L  P
Sbjct: 1736 APLLPVQKDSSKTA----------KGKDAS------HSP-----KGP---------LAPP 1765

Query: 880  SGNLKSPQTPSQLAGMLAGP--AAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSP 937
                 +P T +    +L  P  A+ ++  SPPV    A SPV    P+LP       SSP
Sbjct: 1766 ESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPV----PTLPPKQQFLPSSP 1821

Query: 938  KPPLQSPGIP-----PNHKAPLTMASP--------AMLGNV---ESGGPPPPT--ASQPA 979
               L+SP  P      +   PL    P        ++L N+   +S G P PT  A QP 
Sbjct: 1822 GLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPV 1881

Query: 980  SVNIPGSLPSSTPYTMPPE 998
            + N  GS   S      PE
Sbjct: 1882 TKNNKGSGTESDSDESVPE 1900



 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 163/751 (21%), Positives = 236/751 (31%), Gaps = 131/751 (17%)

Query: 679  RIPVEGPLSPSRG--DFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQK 736
            RIPV  PL       + P  +  +    ++L+   VP+ ++G        G  ++  P  
Sbjct: 502  RIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQ--TVPASLEGAPFSPAQAGLTTKKDPTV 559

Query: 737  MREAGAGPEEMLKLRPGGSD---------MLPAQQKMVPLPFGEHPQQEYGMGPRPFLPM 787
            +    A P+     +   S           L  +    PLP G+         P   +  
Sbjct: 560  LPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGK---------PASSMTS 610

Query: 788  SQGPGSNSGLRNLREPIGPDQRTNSRLSHM--PPLPLNPSSNPTSLNTAPPVQRGLGRKP 845
              G  S++ +       GPD       S +  P +   P  +      AP   +G     
Sbjct: 611  PLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYT 670

Query: 846  LDIS--VAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAA 903
               S  + G+   +P  +P+K  T+  +  P++ + S N     +P      LA    A 
Sbjct: 671  TTASPFLEGTVSLAPKNHPVKEGTLTTL--PLVPTASENCPVAPSPQNTCAPLATLVLAP 728

Query: 904  SIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLG 963
             I            P  + SPSLP                 G PP  K    ++  + L 
Sbjct: 729  EI------------PKSVPSPSLP---------------PAGTPPGTKKVDGISHTSALA 761

Query: 964  NVESGGPPPPTASQPAS--VNIPGSLP-----------SSTPYTMPPEPTLSQNPLSIMM 1010
             V S     PT    AS   +  G+L            S +P T  P            +
Sbjct: 762  PVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPI 821

Query: 1011 SRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNP 1070
              +S    P       +   +   S D      SP  PS    P             P+ 
Sbjct: 822  GNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAP------------TPSA 869

Query: 1071 VVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGP--------GLMSHNPIMGH 1122
            V P   LSP G+T P     + P+P+ V    P  G P  P         + S +P    
Sbjct: 870  VTP---LSPKGVTLP---PKETPTPSVVNLPFPKEG-PATPAPKQAPALSMTSSSPKKAR 922

Query: 1123 GSQEPPMVPQGRMGFPQGFPPVQSPPQ-----QVPFPHNGPSGGQGSFPGGMGFPG-EGP 1176
             +  P  +P          PP  +PP        P P   P+    + P   G P    P
Sbjct: 923  ATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSP 982

Query: 1177 LGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPE--- 1233
             G P+         A   P   GGP + +  G   P   T P  +    P AT  P+   
Sbjct: 983  KGAPT-------PPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKG--SPAATPFPKGAS 1033

Query: 1234 FDLSRIIPSEKPSQTLQYFPRG--EVPGRKQPQGP-GPGFSHMQGMMGEQAPRMGLALPG 1290
               +   PS K S      P+G    P    P    GP    ++G     AP    A P 
Sbjct: 1034 TPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKG-----APTPPAATP- 1087

Query: 1291 MGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPT--LM 1348
               P P G P  P      MP   P   P   + G+  P H+      +  P  P   L 
Sbjct: 1088 ---PSPKGGPATPSPKGAPMP---PAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLA 1141

Query: 1349 SNPAAAVGMIP-GKDRGPAGLYTHPGPVGSP 1378
            + P       P      P G    P P G+P
Sbjct: 1142 TPPPKGAPTTPAATPPSPKGGLATPPPKGAP 1172



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 99/374 (26%), Positives = 128/374 (34%), Gaps = 64/374 (17%)

Query: 6    PKVRSSPSGNTQSSPKSKQEV------MVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQ- 58
            PK   SPS     +P   ++V          P   SP   P  DS  S      G+ +  
Sbjct: 731  PKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYL 790

Query: 59   -SQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPN 117
               PSP        T K  P   GS G     GN +                   P +P 
Sbjct: 791  ADSPSPLGVSVSPQT-KRPPTKKGSAGPDTPIGNLSS------------------PVSPV 831

Query: 118  DDSDIKECNSADHIKSQDSQHTPHSMTPSN---ATAPRSSTP--SHGQTTATEPTPAQKT 172
            + S + E NS     S+DS  T HS TP +   A  P + TP    G T   + TP   T
Sbjct: 832  EASFLPE-NSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETP---T 887

Query: 173  PAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQIS-ALRNDP 231
            P+ V   F  E    A  A  +    ++ S      S  K   + AP     S + +  P
Sbjct: 888  PSVVNLPFPKE--GPATPAPKQAPALSMTSS-----SPKKARATPAPKGIPASPSPKGAP 940

Query: 232  KPLPQQPPAPANQDQNSSQNTRLQP---TPPIP-----------APAPKPAAPPRPLDRE 277
             P    PP+P       S      P   TPP P           AP P  A PP P    
Sbjct: 941  TPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSP---- 996

Query: 278  SPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNR-AVTPVSQGSNSSSADPKAPPPPPV 336
              G          +P + TP  P G+ P +TP  + A TP +    S    P A P P  
Sbjct: 997  KGGPATPSPKGAPTPPAVTPPSPKGS-PAATPFPKGASTPPAATPPSPKGSPAATPLPKG 1055

Query: 337  SSGEPPTLGENPDG 350
            +   P     +P G
Sbjct: 1056 APTTPAATLPSPKG 1069



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 112/495 (22%), Positives = 174/495 (35%), Gaps = 101/495 (20%)

Query: 786  PMSQGPGSNSGLRNLREPIGPDQ---RTNSRLSHMPPLPLNPSSNPTSLNTAP------- 835
            P S     +  +  L  PI P +     N   S + P P    S P  ++T P       
Sbjct: 161  PPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPM 220

Query: 836  -PVQRGLGRKP-----LDISVAGSQV------------HSPGINPLKSPTMH------QV 871
              +Q G+   P       +++A  QV             +PG   LK P           
Sbjct: 221  ASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLST 280

Query: 872  QSPMLGSPSGNLKSPQTPSQLA---GMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPA 928
            QS  + + S     P TP       G    P   +S  S  +LG     P  L  P++  
Sbjct: 281  QSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTG--PSALSDPTVKT 338

Query: 929  PSPGWTSSPKP-PLQSPGIPP----NHKAPLTMAS-PAMLGNVESGGPPPPTASQPASVN 982
             S   +S+    P Q   IPP    N   P T+A+ P +  +V+ G    P+     + +
Sbjct: 339  ISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKG----PSTISSITCS 394

Query: 983  IPGSLPSSTPYTMPPEPTL----SQN-----PLSIMMSRMSKFAMPSSTPLYHDAIKTVA 1033
              GSL  +T +++ P  +L    S N     PL   M   S      +TPL      T+A
Sbjct: 395  PSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSV----GTTPLVVTNPCTIA 450

Query: 1034 SSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMP 1093
            ++   +    +   P M++ P   I   +P      PV P    + +  T  +  S  +P
Sbjct: 451  AAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLP 510

Query: 1094 SPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQS------P 1147
             P  +  N+P   +   P             ++   VP    G P  F P Q+       
Sbjct: 511  DPEDL-KNLPSSVLVKFP-----------TQKDLQTVPASLEGAP--FSPAQAGLTTKKD 556

Query: 1148 PQQVPF----PHNGPSGGQGSFPGGMGFPGEG-----------PLGRPSNLPQS----SA 1188
            P  +P     P N PS    S    +    E            P+G+P++   S    ++
Sbjct: 557  PTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNS 616

Query: 1189 DAALCKPGGPGGPDS 1203
             A++ K     GPDS
Sbjct: 617  SASVIKTDSYAGPDS 631



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 73/321 (22%), Positives = 106/321 (33%), Gaps = 36/321 (11%)

Query: 744  PEEMLKLRPGGSDMLPAQQ-KMVPLPFGEHPQQEYGMG-PRPFLPMSQGPGSNS---GLR 798
            P E  +  P     LP  Q +   LP          +G P P LP    P          
Sbjct: 2    PGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAA 61

Query: 799  NLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSP 858
            N   P  P   T +      P P + S     L TAP     L                 
Sbjct: 62   NQASPF-PSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNL-------------- 106

Query: 859  GINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASP 918
             I P  SP    + SPM+        S   P  L  +       +S   P +L S  +  
Sbjct: 107  -IGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVA 165

Query: 919  VHLKSPSLPAPSPGWTSSPKPPLQS--PGIPPNHKAPLTMASPAMLGNVESGGPPPPTAS 976
            V      +   +P   S PK  L      + PN K   T + P ++  V      P  + 
Sbjct: 166  VAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKG--TPSPPCIVSTVPYHCVTPMASI 223

Query: 977  QPASVNIPGSLPSSTPYTMPP---EPTLS------QNPLSIMMSRMSKFAMPSSTPLYHD 1027
            Q    ++P + P++T     P   + T+S      QNP S  +S     + P++  L   
Sbjct: 224  QSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGS--LSLKGPVSPPAALSLSTQ 281

Query: 1028 AIKTVASSDDDSPPARSPNLP 1048
            ++  V SS   + P   P+ P
Sbjct: 282  SLPVVTSSQKTAGPNTPPDFP 302



 Score = 35.4 bits (80), Expect = 0.40
 Identities = 78/349 (22%), Positives = 115/349 (32%), Gaps = 79/349 (22%)

Query: 193 LKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPP--APANQDQNSSQ 250
           + G+    V    Q +   + E +  P+++ +S      +P P  PP  +PA Q    S 
Sbjct: 1   MPGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSA 60

Query: 251 NTRLQPTP--------PIPAPAPK------------PAAP------------PRPLDRES 278
             +  P P        P+  P P+            P AP            P  L   S
Sbjct: 61  ANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALAS 120

Query: 279 PGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTP-----------VSQGSNSSSAD 327
           P +   L    G+P+SS PL      P+S   + A  P              GS  + + 
Sbjct: 121 PMIAPTL---KGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSA 177

Query: 328 PKAPPPPPVSSGEPPT-LGENPDG------------------LSQEQLEHRERSLQTLRD 368
           P AP  P  +  + P+ +  NP G                  ++  Q         T   
Sbjct: 178 PIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTT 237

Query: 369 IQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGA 428
              +  P  K+ T +      QNPG L    K P  P  A+   +QSL       T    
Sbjct: 238 TLAIASPQVKDTTISSVLISPQNPGSLS--LKGPVSPPAALSLSTQSL----PVVTSSQK 291

Query: 429 PFGPQGHRDVPFSPDEMVPPSMNSQSGTI------GPDHLDHMTPEQIA 471
             GP    D P S    + P   S  G++      GP  L   T + I+
Sbjct: 292 TAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTIS 340


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.132    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,407,404
Number of Sequences: 37866
Number of extensions: 6309321
Number of successful extensions: 60909
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 380
Number of HSP's successfully gapped in prelim test: 2228
Number of HSP's that attempted gapping in prelim test: 25103
Number of HSP's gapped (non-prelim): 21662
length of query: 1426
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1311
effective length of database: 13,892,928
effective search space: 18213628608
effective search space used: 18213628608
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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