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Search of human proteins with 71480164
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71480164 harmonin isoform a [Homo sapiens]
(552 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71480164 harmonin isoform a [Homo sapiens] 1093 0.0
gi|41281808 harmonin isoform b3 [Homo sapiens] 791 0.0
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 141 2e-33
gi|13376349 PDZ domain containing 7 [Homo sapiens] 108 2e-23
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 78 2e-14
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 78 2e-14
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 78 2e-14
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 78 2e-14
gi|45827729 scribble isoform b [Homo sapiens] 75 2e-13
gi|45827731 scribble isoform a [Homo sapiens] 75 2e-13
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 73 6e-13
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 72 1e-12
gi|148746189 multiple PDZ domain protein [Homo sapiens] 72 2e-12
gi|194018553 solute carrier family 9 isoform 3 regulator 2 isofo... 67 4e-11
gi|71897229 solute carrier family 9 isoform 3 regulator 2 isofor... 67 4e-11
gi|112382257 InaD-like [Homo sapiens] 66 9e-11
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 64 5e-10
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 63 6e-10
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 61 3e-09
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 60 4e-09
gi|21630285 PDZ domain containing 3 [Homo sapiens] 60 4e-09
gi|21361142 PDZ domain containing 1 [Homo sapiens] 60 5e-09
gi|7706025 PDZ domain containing 11 [Homo sapiens] 60 5e-09
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 59 2e-08
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 59 2e-08
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 59 2e-08
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 58 2e-08
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 58 2e-08
gi|87196343 PDZ domain containing 2 [Homo sapiens] 58 2e-08
gi|9507165 syntrophin, gamma 2 [Homo sapiens] 58 2e-08
>gi|71480164 harmonin isoform a [Homo sapiens]
Length = 552
Score = 1093 bits (2826), Expect = 0.0
Identities = 552/552 (100%), Positives = 552/552 (100%)
Query: 1 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD 60
MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
Sbjct: 1 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD 60
Query: 61 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG 120
AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
Sbjct: 61 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG 120
Query: 121 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL 180
GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
Sbjct: 121 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL 180
Query: 181 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH 240
TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
Sbjct: 181 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH 240
Query: 241 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD
Sbjct: 241 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
Query: 301 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 360
RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
Sbjct: 301 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 360
Query: 361 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG 420
EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG
Sbjct: 361 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG 420
Query: 421 GTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVV 480
GTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVV
Sbjct: 421 GTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVV 480
Query: 481 VSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVC 540
VSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVC
Sbjct: 481 VSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVC 540
Query: 541 PPKEYDDELTFF 552
PPKEYDDELTFF
Sbjct: 541 PPKEYDDELTFF 552
>gi|41281808 harmonin isoform b3 [Homo sapiens]
Length = 899
Score = 791 bits (2044), Expect = 0.0
Identities = 403/403 (100%), Positives = 403/403 (100%)
Query: 1 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD 60
MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
Sbjct: 1 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD 60
Query: 61 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG 120
AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
Sbjct: 61 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG 120
Query: 121 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL 180
GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
Sbjct: 121 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL 180
Query: 181 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH 240
TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
Sbjct: 181 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH 240
Query: 241 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD
Sbjct: 241 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
Query: 301 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 360
RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
Sbjct: 301 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 360
Query: 361 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPK 403
EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPK
Sbjct: 361 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPK 403
Score = 249 bits (635), Expect = 6e-66
Identities = 122/122 (100%), Positives = 122/122 (100%)
Query: 428 QDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYER 487
QDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYER
Sbjct: 728 QDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYER 787
Query: 488 GAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDD 547
GAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDD
Sbjct: 788 GAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDD 847
Query: 548 EL 549
EL
Sbjct: 848 EL 849
Score = 35.4 bits (80), Expect = 0.14
Identities = 28/79 (35%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 440 YSMFTPEQIMG-KDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVK 498
Y TP + K+VRL R+ EG L L++ GG++ G + +S + + G A+ G +
Sbjct: 74 YDQLTPRRSRKLKEVRLDRLHPEG-LGLSVRGGLEFGCG-LFISHLIKGGQADSVG-LQV 130
Query: 499 GDEIMAINGKIVTDYTLAE 517
GDEI+ ING ++ T E
Sbjct: 131 GDEIVRINGYSISSCTHEE 149
Score = 35.4 bits (80), Expect = 0.14
Identities = 28/79 (35%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 74 YDQLTPRRSRKLKEVRLDRLHPEG-LGLSVRGGLEFGCG-LFISHLIKGGQADSVG-LQV 130
Y TP + K+VRL R+ EG L L++ GG++ G + +S + + G A+ G +
Sbjct: 740 YSMFTPEQIMG-KDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVK 798
Query: 131 GDEIVRINGYSISSCTHEE 149
GDEI+ ING ++ T E
Sbjct: 799 GDEIMAINGKIVTDYTLAE 817
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 141 bits (355), Expect = 2e-33
Identities = 106/316 (33%), Positives = 159/316 (50%), Gaps = 40/316 (12%)
Query: 11 HKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKH 70
H+ + ++AE++ L YH +V LV L+++++ P + L +R +IP
Sbjct: 43 HQALTALLSEAEREQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSD 102
Query: 71 QVEYDQLT----------PRR--------SRKLKEVRLDRLHP----EGLGLSVRGGLEF 108
Q+ +DQ T P R S EVRL L EGLG S+RGG E
Sbjct: 103 QLLFDQYTAEGLYLPATTPYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEH 162
Query: 109 GCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIG 168
G G+++S + G A+ GL+VGD+I+R+N S++ TH E + ++ K + + V G
Sbjct: 163 GVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAG 222
Query: 169 LIPVKSSPDEPLTWQYVD---QFVSESGGVRGSLGSP-----GNRENK--------EKKV 212
IP + TW VD + +S G+ G G+R + EKKV
Sbjct: 223 RIPGGYVTNHIYTW--VDPQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKV 280
Query: 213 FISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHK 272
+ L R LG +I G GI+I+ V PGS + GL++GDQI+EVNG F N+ H
Sbjct: 281 NLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHD 340
Query: 273 EAVNVLKSSRSLTISI 288
EAV +LKSSR L +++
Sbjct: 341 EAVRLLKSSRHLILTV 356
Score = 73.2 bits (178), Expect = 6e-13
Identities = 36/121 (29%), Positives = 69/121 (57%), Gaps = 3/121 (2%)
Query: 86 KEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSC 145
K+V L LGL++RGG E+G G++I+ + G +A+ GL+VGD+I+ +NG S +
Sbjct: 278 KKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNI 337
Query: 146 THEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTW---QYVDQFVSESGGVRGSLGSP 202
H+E + L+++ + + + V+ +G +P + + W + + ++ S G G L +
Sbjct: 338 LHDEAVRLLKSSRHLILTVKDVGRLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTE 397
Query: 203 G 203
G
Sbjct: 398 G 398
Score = 64.7 bits (156), Expect = 2e-10
Identities = 32/71 (45%), Positives = 45/71 (63%)
Query: 221 GLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
GLG SI G GI++S V+PGSL+ + GL +GDQI+ VN + + H EAV LK
Sbjct: 151 GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKG 210
Query: 281 SRSLTISIVAA 291
S+ L +S+ +A
Sbjct: 211 SKKLVLSVYSA 221
Score = 35.8 bits (81), Expect = 0.10
Identities = 26/71 (36%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
Query: 453 VRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTD 512
V L R K L ++ GG + +G + VS V AE+ G V GD+I+ +N K +
Sbjct: 141 VSLRRAKAHEGLGFSIRGGSEHGVG-IYVSLVEPGSLAEKEGLRV-GDQILRVNDKSLAR 198
Query: 513 YTLAEAEAALQ 523
T AEA AL+
Sbjct: 199 VTHAEAVKALK 209
Score = 34.3 bits (77), Expect = 0.31
Identities = 26/97 (26%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 445 PEQIMGKDVRLLRIKKEGS-LDLALEGGVDS--PIGKVVVSAVYERGAAERHGGIVKGDE 501
P ++ L+R+KK + L +A+EGG ++ P+ ++V + G+A G + G
Sbjct: 806 PPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIV--TIQRGGSAHNCGQLKVGHV 863
Query: 502 IMAINGKIVTDYTLAEAEAALQKAW-NQGGDWIDLVV 537
I+ +NG + EA + +A+ + D+ID +V
Sbjct: 864 ILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLV 900
Score = 29.3 bits (64), Expect = 9.8
Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 2/59 (3%)
Query: 98 LGLSVRGGLEFGCGL-FISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLI 154
LG+++ GG L I + +GG A + G L+VG I+ +NG ++ H E +I
Sbjct: 826 LGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARII 884
>gi|13376349 PDZ domain containing 7 [Homo sapiens]
Length = 517
Score = 108 bits (269), Expect = 2e-23
Identities = 68/208 (32%), Positives = 109/208 (52%), Gaps = 7/208 (3%)
Query: 85 LKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISS 144
+ VR+++ LG SVRGG E G G+F+S + +G A+ GL VGD+I +NG S+ S
Sbjct: 84 IHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLES 143
Query: 145 CTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYV--DQFVSESGGVRGSLGSP 202
T + ++ + + + VR +G +P E TW V + V E GS S
Sbjct: 144 TTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEK---CGSTPSD 200
Query: 203 GNRENKEKKVFISLVGSRG--LGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVE 260
+ E+ +++ S LG +I G GI++S V G L+ E G+++GDQ++
Sbjct: 201 TSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLA 260
Query: 261 VNGVDFSNLDHKEAVNVLKSSRSLTISI 288
NGV F ++ H +AV VLK + ++I
Sbjct: 261 ANGVRFDDISHSQAVEVLKGQTHIMLTI 288
Score = 62.0 bits (149), Expect = 1e-09
Identities = 41/150 (27%), Positives = 71/150 (47%), Gaps = 15/150 (10%)
Query: 98 LGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTK 157
LG ++RGG EFG G+++S + GG A+ G++VGD+++ NG +H + + +++ +
Sbjct: 222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQ 281
Query: 158 KTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLV 217
+ + ++ G P W +D+ S GV L SP + + S V
Sbjct: 282 THIMLTIKETGRYPAYKEMVSEYCW--LDRL---SNGVLQQL-SPASESS-------SSV 328
Query: 218 GSRGLGCSISSG--PIQKPGIFISHVKPGS 245
S SSG P + I + +PGS
Sbjct: 329 SSCASSAPYSSGSLPSDRMDICLGQEEPGS 358
Score = 33.9 bits (76), Expect = 0.40
Identities = 23/72 (31%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 453 VRLLRIKKE--GSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIV 510
+ +R++K G L ++ GG + +G + VS V E +AER G+ GD+I +NG +
Sbjct: 84 IHSVRVEKSPAGRLGFSVRGGSEHGLG-IFVSKVEEGSSAER-AGLCVGDKITEVNGLSL 141
Query: 511 TDYTLAEAEAAL 522
T+ A L
Sbjct: 142 ESTTMGSAVKVL 153
Score = 30.0 bits (66), Expect = 5.8
Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 7/85 (8%)
Query: 444 TPEQIMGKD-----VRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVK 498
TP +D V L + L + GG + +G + VS V G AE +G I
Sbjct: 197 TPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLG-IYVSKVDHGGLAEENG-IKV 254
Query: 499 GDEIMAINGKIVTDYTLAEAEAALQ 523
GD+++A NG D + ++A L+
Sbjct: 255 GDQVLAANGVRFDDISHSQAVEVLK 279
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 77.8 bits (190), Expect = 2e-14
Identities = 105/461 (22%), Positives = 193/461 (41%), Gaps = 77/461 (16%)
Query: 82 SRKLKEVRLDRLHPEGLGLSVRGG-----LEFGCGLFISHLIKGGQADSVG-LQVGDEIV 135
+ K+ E++L + P+GLG S+ GG + ++++ +I+GG A G LQ+GD+I+
Sbjct: 198 AEKVMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 256
Query: 136 RINGYSISSCTHEEVINLIR-TKKTVSIKV---RHIGLIPVKSSPDEPLTW-QYVDQFVS 190
+N + HE+ + ++ T V +KV + L + PD ++ Q++D +S
Sbjct: 257 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEIS 316
Query: 191 ESGGVRGSLG-----------SPGNRE-------NKEKKVFISLVGSRGLGCSISSGPIQ 232
S + SP ++ +E + + GS GLG +I G
Sbjct: 317 HSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGE-D 375
Query: 233 KPGIFISHV---KPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
GIFIS + P LS E L GDQI+ VNGVD N H++A LK++ T++I+
Sbjct: 376 GEGIFISFILAGGPADLSGE--LRKGDQILSVNGVDLRNASHEQAAIALKNA-GQTVTII 432
Query: 290 AAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKA 349
A E + ++ + R++ + L + + + + K+ +
Sbjct: 433 AQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLS 492
Query: 350 AEENERYRKEMEQIVEEEEKF-------------------------KKQWE----EDWGS 380
+ R+ + I +E++ +++W +DWGS
Sbjct: 493 QALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGS 552
Query: 381 -------KEQLLLPKTIT-AEVH---PVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQD 429
++ +L +T+T EVH P+ + P D+ + L D G +
Sbjct: 553 SSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRP 612
Query: 430 FRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEG 470
R+YE Y + + M KD++ + + G + L G
Sbjct: 613 KREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYG 653
Score = 45.1 bits (105), Expect = 2e-04
Identities = 28/73 (38%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 218 GSRGLGCSISSGPIQK-----PGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDH 271
G+ GLG SI+ G P IFI+ + PG +A+ G L + D I+ VN VD + H
Sbjct: 114 GNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 173
Query: 272 KEAVNVLKSSRSL 284
AV LK + S+
Sbjct: 174 SAAVEALKEAGSI 186
Score = 35.4 bits (80), Expect = 0.14
Identities = 23/81 (28%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 451 KDVRLLRIKKEGSLDLALEGGVDSPI----GKVVVSAVYERGAAERHGGIVKGDEIMAIN 506
K + + IK L ++ GGV + + V+ + E GAA + G + GD+I+A+N
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 507 GKIVTDYTLAEAEAALQKAWN 527
+ D +A AAL+ ++
Sbjct: 260 SVGLEDVMHEDAVAALKNTYD 280
Score = 32.7 bits (73), Expect = 0.89
Identities = 26/100 (26%), Positives = 49/100 (49%), Gaps = 7/100 (7%)
Query: 446 EQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAI 505
E I + R++ + L + GG D + +S + G A+ G + KGD+I+++
Sbjct: 348 EDIPREPRRIVIHRGSTGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSV 405
Query: 506 NGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEY 545
NG + + + +A AL+ A G + ++A P+EY
Sbjct: 406 NGVDLRNASHEQAAIALKNA----GQTV-TIIAQYKPEEY 440
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 77.8 bits (190), Expect = 2e-14
Identities = 105/461 (22%), Positives = 193/461 (41%), Gaps = 77/461 (16%)
Query: 82 SRKLKEVRLDRLHPEGLGLSVRGG-----LEFGCGLFISHLIKGGQADSVG-LQVGDEIV 135
+ K+ E++L + P+GLG S+ GG + ++++ +I+GG A G LQ+GD+I+
Sbjct: 152 AEKVMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 210
Query: 136 RINGYSISSCTHEEVINLIR-TKKTVSIKV---RHIGLIPVKSSPDEPLTW-QYVDQFVS 190
+N + HE+ + ++ T V +KV + L + PD ++ Q++D +S
Sbjct: 211 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEIS 270
Query: 191 ESGGVRGSLG-----------SPGNRE-------NKEKKVFISLVGSRGLGCSISSGPIQ 232
S + SP ++ +E + + GS GLG +I G
Sbjct: 271 HSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGE-D 329
Query: 233 KPGIFISHV---KPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
GIFIS + P LS E L GDQI+ VNGVD N H++A LK++ T++I+
Sbjct: 330 GEGIFISFILAGGPADLSGE--LRKGDQILSVNGVDLRNASHEQAAIALKNA-GQTVTII 386
Query: 290 AAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKA 349
A E + ++ + R++ + L + + + + K+ +
Sbjct: 387 AQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLS 446
Query: 350 AEENERYRKEMEQIVEEEEKF-------------------------KKQWE----EDWGS 380
+ R+ + I +E++ +++W +DWGS
Sbjct: 447 QALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGS 506
Query: 381 -------KEQLLLPKTIT-AEVH---PVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQD 429
++ +L +T+T EVH P+ + P D+ + L D G +
Sbjct: 507 SSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRP 566
Query: 430 FRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEG 470
R+YE Y + + M KD++ + + G + L G
Sbjct: 567 KREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYG 607
Score = 45.1 bits (105), Expect = 2e-04
Identities = 28/73 (38%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 218 GSRGLGCSISSGPIQK-----PGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDH 271
G+ GLG SI+ G P IFI+ + PG +A+ G L + D I+ VN VD + H
Sbjct: 68 GNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 127
Query: 272 KEAVNVLKSSRSL 284
AV LK + S+
Sbjct: 128 SAAVEALKEAGSI 140
Score = 35.4 bits (80), Expect = 0.14
Identities = 23/81 (28%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 451 KDVRLLRIKKEGSLDLALEGGVDSPI----GKVVVSAVYERGAAERHGGIVKGDEIMAIN 506
K + + IK L ++ GGV + + V+ + E GAA + G + GD+I+A+N
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 507 GKIVTDYTLAEAEAALQKAWN 527
+ D +A AAL+ ++
Sbjct: 214 SVGLEDVMHEDAVAALKNTYD 234
Score = 32.7 bits (73), Expect = 0.89
Identities = 26/100 (26%), Positives = 49/100 (49%), Gaps = 7/100 (7%)
Query: 446 EQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAI 505
E I + R++ + L + GG D + +S + G A+ G + KGD+I+++
Sbjct: 302 EDIPREPRRIVIHRGSTGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSV 359
Query: 506 NGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEY 545
NG + + + +A AL+ A G + ++A P+EY
Sbjct: 360 NGVDLRNASHEQAAIALKNA----GQTV-TIIAQYKPEEY 394
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 77.8 bits (190), Expect = 2e-14
Identities = 76/260 (29%), Positives = 125/260 (48%), Gaps = 41/260 (15%)
Query: 82 SRKLKEVRLDRLHPEGLGLSVRGG-----LEFGCGLFISHLIKGGQADSVG-LQVGDEIV 135
S K+ E++L + P+GLG S+ GG + ++++ +I+GG A G LQ+GD+++
Sbjct: 314 SEKIMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLL 372
Query: 136 RINGYSISSCTHEEVINLIR-TKKTVSIKV-------RHIGLIP--VKSSPDEPLTWQYV 185
+N + THEE + ++ T V +KV + G P + +S +P V
Sbjct: 373 AVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQP-----V 427
Query: 186 DQFVSESGGVRGSLGSP-----------GNRE-NKEKKVFISLVGSRGLGCSISSGPIQK 233
D VS S + + SP G+ E +E + + GS GLG +I G
Sbjct: 428 DNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGE-DG 486
Query: 234 PGIFISHV---KPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVA 290
GIFIS + P LS E L GD+I+ VN VD H++A LK++ ++IVA
Sbjct: 487 EGIFISFILAGGPADLSGE--LRKGDRIISVNSVDLRAASHEQAAAALKNA-GQAVTIVA 543
Query: 291 AAGRELFMTDRERLAEARQR 310
E + ++ + R++
Sbjct: 544 QYRPEEYSRFEAKIHDLREQ 563
Score = 56.2 bits (134), Expect = 8e-08
Identities = 59/228 (25%), Positives = 102/228 (44%), Gaps = 51/228 (22%)
Query: 86 KEVRLDRLHPEGLGLSVRGGLEF-----GCGLFISHLIKGGQADSVG-LQVGDEIVRING 139
+E+ L+R + GLG S+ GG + +FI+ +I GG A G L+V D I+R+N
Sbjct: 223 EEITLERGN-SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNE 281
Query: 140 YSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSL 199
+ TH + + ++ ++ V +V V
Sbjct: 282 VDVRDVTHSKAVEALKEAGSI------------------------VRLYVKRRKPV---- 313
Query: 200 GSPGNRENKEKKVFISLV-GSRGLGCSISSGPIQK--PG---IFISHVKPGSLSAEVG-L 252
EK + I L+ G +GLG SI+ G + PG I+++ + G + + G L
Sbjct: 314 --------SEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKL 365
Query: 253 EIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
+IGD+++ VN V + H+EAV LK++ + + A ++M D
Sbjct: 366 QIGDKLLAVNNVCLEEVTHEEAVTALKNTSDF-VYLKVAKPTSMYMND 412
Score = 35.8 bits (81), Expect = 0.10
Identities = 26/92 (28%), Positives = 45/92 (48%), Gaps = 8/92 (8%)
Query: 451 KDVRLLRIKKEGSLDLALEGGVDSPI----GKVVVSAVYERGAAERHGGIVKGDEIMAIN 506
K + + IK L ++ GGV + + V+ + E GAA + G + GD+++A+N
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 507 GKIVTDYTLAEAEAALQKAWNQGGDWIDLVVA 538
+ + T EA AL+ D++ L VA
Sbjct: 376 NVCLEEVTHEEAVTALKNT----SDFVYLKVA 403
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 77.8 bits (190), Expect = 2e-14
Identities = 76/260 (29%), Positives = 125/260 (48%), Gaps = 41/260 (15%)
Query: 82 SRKLKEVRLDRLHPEGLGLSVRGG-----LEFGCGLFISHLIKGGQADSVG-LQVGDEIV 135
S K+ E++L + P+GLG S+ GG + ++++ +I+GG A G LQ+GD+++
Sbjct: 314 SEKIMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLL 372
Query: 136 RINGYSISSCTHEEVINLIR-TKKTVSIKV-------RHIGLIP--VKSSPDEPLTWQYV 185
+N + THEE + ++ T V +KV + G P + +S +P V
Sbjct: 373 AVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQP-----V 427
Query: 186 DQFVSESGGVRGSLGSP-----------GNRE-NKEKKVFISLVGSRGLGCSISSGPIQK 233
D VS S + + SP G+ E +E + + GS GLG +I G
Sbjct: 428 DNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGE-DG 486
Query: 234 PGIFISHV---KPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVA 290
GIFIS + P LS E L GD+I+ VN VD H++A LK++ ++IVA
Sbjct: 487 EGIFISFILAGGPADLSGE--LRKGDRIISVNSVDLRAASHEQAAAALKNA-GQAVTIVA 543
Query: 291 AAGRELFMTDRERLAEARQR 310
E + ++ + R++
Sbjct: 544 QYRPEEYSRFEAKIHDLREQ 563
Score = 56.2 bits (134), Expect = 8e-08
Identities = 59/228 (25%), Positives = 102/228 (44%), Gaps = 51/228 (22%)
Query: 86 KEVRLDRLHPEGLGLSVRGGLEF-----GCGLFISHLIKGGQADSVG-LQVGDEIVRING 139
+E+ L+R + GLG S+ GG + +FI+ +I GG A G L+V D I+R+N
Sbjct: 223 EEITLERGN-SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNE 281
Query: 140 YSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSL 199
+ TH + + ++ ++ V +V V
Sbjct: 282 VDVRDVTHSKAVEALKEAGSI------------------------VRLYVKRRKPV---- 313
Query: 200 GSPGNRENKEKKVFISLV-GSRGLGCSISSGPIQK--PG---IFISHVKPGSLSAEVG-L 252
EK + I L+ G +GLG SI+ G + PG I+++ + G + + G L
Sbjct: 314 --------SEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKL 365
Query: 253 EIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
+IGD+++ VN V + H+EAV LK++ + + A ++M D
Sbjct: 366 QIGDKLLAVNNVCLEEVTHEEAVTALKNTSDF-VYLKVAKPTSMYMND 412
Score = 35.8 bits (81), Expect = 0.10
Identities = 26/92 (28%), Positives = 45/92 (48%), Gaps = 8/92 (8%)
Query: 451 KDVRLLRIKKEGSLDLALEGGVDSPI----GKVVVSAVYERGAAERHGGIVKGDEIMAIN 506
K + + IK L ++ GGV + + V+ + E GAA + G + GD+++A+N
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 507 GKIVTDYTLAEAEAALQKAWNQGGDWIDLVVA 538
+ + T EA AL+ D++ L VA
Sbjct: 376 NVCLEEVTHEEAVTALKNT----SDFVYLKVA 403
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 75.1 bits (183), Expect = 2e-13
Identities = 65/214 (30%), Positives = 108/214 (50%), Gaps = 26/214 (12%)
Query: 97 GLGLSVRGGLEFGC------GLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEV 150
GLG+S+ GG G+FIS + + G A G++VGD+++ +NG ++ H E
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEA 796
Query: 151 INLIRTKKT-VSIKV-RHIGLIPVKSSPDEPLTWQYVDQF---VSESGGVRGSL---GSP 202
+ +R T V ++V R + P + PL + D + GG+R L SP
Sbjct: 797 VEALRGAGTAVQMRVWRERMVEPENAVTITPLRPE--DDYSPRERRGGGLRLPLLPPESP 854
Query: 203 GNRENKEKKVFISLVGSRGLGCSISSGPIQKP------GIFISHVKPGSLSAEVG-LEIG 255
G +++ V RGLG SI+ G P GIF+S + G + G L++G
Sbjct: 855 G--PLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
Query: 256 DQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
D+++ +NGVD + H AV++L ++ S TI+++
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLL-TAASPTIALL 945
Score = 72.0 bits (175), Expect = 1e-12
Identities = 68/227 (29%), Positives = 106/227 (46%), Gaps = 51/227 (22%)
Query: 85 LKEVRLDRLHPEGLGLSVRGGLE-----FGC---GLFISHLIKGGQADSVGLQVGDEIVR 136
++E+RL R LGLS+ GG + FG G+FIS ++ G A GL+VGD I+
Sbjct: 1002 VEEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILA 1060
Query: 137 INGYSISSCTHEEVIN-LIRTKKTVSIKVRHIGLIP------VKSSPDEPLTWQYVDQFV 189
+NG + TH+E ++ L+R +S+ VR P ++ +P E L +
Sbjct: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLG-------I 1113
Query: 190 SESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKP-GSLSA 248
S GG RG G+P + ++ GIFIS V P G+
Sbjct: 1114 SIRGGARGHAGNPRDPTDE--------------------------GIFISKVSPTGAAGR 1147
Query: 249 EVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRE 295
+ L +G +++EVN L H EAV +L+S T++++ G E
Sbjct: 1148 DGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD-TLTVLVCDGFE 1193
Score = 50.8 bits (120), Expect = 3e-06
Identities = 30/83 (36%), Positives = 43/83 (51%), Gaps = 6/83 (7%)
Query: 205 RENKEKKVFISLVGSRGLGCSISSGPIQKP------GIFISHVKPGSLSAEVGLEIGDQI 258
R +E+ L + GLG SI+ G P GIFIS V +A G+ +GD++
Sbjct: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780
Query: 259 VEVNGVDFSNLDHKEAVNVLKSS 281
+EVNGV +H EAV L+ +
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGA 803
Score = 39.3 bits (90), Expect = 0.009
Identities = 32/79 (40%), Positives = 43/79 (54%), Gaps = 10/79 (12%)
Query: 451 KDVRLLRIKKEGSLDLALEGGVDS---PIGK----VVVSAVYERGAAERHGGIVKGDEIM 503
+++RL R G L L++ GG D P G V +S V RG A R G+ GD I+
Sbjct: 1003 EEIRLPRAG--GPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLRVGDRIL 1059
Query: 504 AINGKIVTDYTLAEAEAAL 522
A+NG+ V D T EA +AL
Sbjct: 1060 AVNGQDVRDATHQEAVSAL 1078
Score = 33.1 bits (74), Expect = 0.68
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 459 KKEGSLDLALEGGVDSPIGK-----VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTD 512
+ E L ++ GG S + + VS + E GAA R G + GD +++ING VT+
Sbjct: 867 RSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE 925
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 75.1 bits (183), Expect = 2e-13
Identities = 65/214 (30%), Positives = 108/214 (50%), Gaps = 26/214 (12%)
Query: 97 GLGLSVRGGLEFGC------GLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEV 150
GLG+S+ GG G+FIS + + G A G++VGD+++ +NG ++ H E
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEA 796
Query: 151 INLIRTKKT-VSIKV-RHIGLIPVKSSPDEPLTWQYVDQF---VSESGGVRGSL---GSP 202
+ +R T V ++V R + P + PL + D + GG+R L SP
Sbjct: 797 VEALRGAGTAVQMRVWRERMVEPENAVTITPLRPE--DDYSPRERRGGGLRLPLLPPESP 854
Query: 203 GNRENKEKKVFISLVGSRGLGCSISSGPIQKP------GIFISHVKPGSLSAEVG-LEIG 255
G +++ V RGLG SI+ G P GIF+S + G + G L++G
Sbjct: 855 G--PLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
Query: 256 DQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
D+++ +NGVD + H AV++L ++ S TI+++
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLL-TAASPTIALL 945
Score = 72.0 bits (175), Expect = 1e-12
Identities = 68/227 (29%), Positives = 106/227 (46%), Gaps = 51/227 (22%)
Query: 85 LKEVRLDRLHPEGLGLSVRGGLE-----FGC---GLFISHLIKGGQADSVGLQVGDEIVR 136
++E+RL R LGLS+ GG + FG G+FIS ++ G A GL+VGD I+
Sbjct: 1002 VEEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILA 1060
Query: 137 INGYSISSCTHEEVIN-LIRTKKTVSIKVRHIGLIP------VKSSPDEPLTWQYVDQFV 189
+NG + TH+E ++ L+R +S+ VR P ++ +P E L +
Sbjct: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLG-------I 1113
Query: 190 SESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKP-GSLSA 248
S GG RG G+P + ++ GIFIS V P G+
Sbjct: 1114 SIRGGARGHAGNPRDPTDE--------------------------GIFISKVSPTGAAGR 1147
Query: 249 EVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRE 295
+ L +G +++EVN L H EAV +L+S T++++ G E
Sbjct: 1148 DGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD-TLTVLVCDGFE 1193
Score = 50.8 bits (120), Expect = 3e-06
Identities = 30/83 (36%), Positives = 43/83 (51%), Gaps = 6/83 (7%)
Query: 205 RENKEKKVFISLVGSRGLGCSISSGPIQKP------GIFISHVKPGSLSAEVGLEIGDQI 258
R +E+ L + GLG SI+ G P GIFIS V +A G+ +GD++
Sbjct: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780
Query: 259 VEVNGVDFSNLDHKEAVNVLKSS 281
+EVNGV +H EAV L+ +
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGA 803
Score = 39.3 bits (90), Expect = 0.009
Identities = 32/79 (40%), Positives = 43/79 (54%), Gaps = 10/79 (12%)
Query: 451 KDVRLLRIKKEGSLDLALEGGVDS---PIGK----VVVSAVYERGAAERHGGIVKGDEIM 503
+++RL R G L L++ GG D P G V +S V RG A R G+ GD I+
Sbjct: 1003 EEIRLPRAG--GPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLRVGDRIL 1059
Query: 504 AINGKIVTDYTLAEAEAAL 522
A+NG+ V D T EA +AL
Sbjct: 1060 AVNGQDVRDATHQEAVSAL 1078
Score = 33.1 bits (74), Expect = 0.68
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 459 KKEGSLDLALEGGVDSPIGK-----VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTD 512
+ E L ++ GG S + + VS + E GAA R G + GD +++ING VT+
Sbjct: 867 RSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE 925
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 73.2 bits (178), Expect = 6e-13
Identities = 86/317 (27%), Positives = 141/317 (44%), Gaps = 49/317 (15%)
Query: 37 MDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRK----LKEVRLDR 92
MD + V D L +NE + + R + LK +L RR + + EV L +
Sbjct: 173 MDGRLGVNDCVLRVNEVDVSEVVHS-RAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLK 231
Query: 93 LHPEGLGLSVRGGL-----EFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCT 146
P+GLG S+ GG+ ++I+ +I+GG A G LQ+GD ++ +N ++
Sbjct: 232 -GPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVR 290
Query: 147 HEEVI-NLIRTKKTVSIKVRHIGLIPVK---SSPDEPLTWQYV-DQFVSES------GGV 195
HEE + +L T V +KV G + + + PD T+ + D +S + G V
Sbjct: 291 HEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAV 350
Query: 196 RGSLGSPGNRE-------------------NKEKKVFISLVGSRGLGCSISSGPIQKPGI 236
+ P + +E + I GS GLG +I G GI
Sbjct: 351 ESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGE-DGEGI 409
Query: 237 FISHVK---PGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAG 293
F+S + P LS E L GD+I+ VNGV+ N H++A LK + +++IVA
Sbjct: 410 FVSFILAGGPADLSGE--LRRGDRILSVNGVNLRNATHEQAAAALKRA-GQSVTIVAQYR 466
Query: 294 RELFMTDRERLAEARQR 310
E + ++ + R++
Sbjct: 467 PEEYSRFESKIHDLREQ 483
Score = 49.3 bits (116), Expect = 9e-06
Identities = 82/371 (22%), Positives = 136/371 (36%), Gaps = 80/371 (21%)
Query: 218 GSRGLGCSISSG-----PIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDH 271
G+ GLG SI+ G PGIFI+ + PG +A G L + D ++ VN VD S + H
Sbjct: 137 GNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVH 196
Query: 272 KEAV---------------------------NVLKSSRSLTISIVAAAGRELFMTDRE-- 302
AV N+LK + L SI G + D
Sbjct: 197 SRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIY 256
Query: 303 --RLAEARQRELQRQELLMQKRLAMESNKILQEQQEME-----RQRRKEIAQKAAEENER 355
++ E + + L + RL +N LQ+ + E + + K A+
Sbjct: 257 ITKIIEGGAAQKDGR-LQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSL 315
Query: 356 YRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEV-HPVPLRKPKYDQGVEPELEP 414
+ +M + F + L + ++V +P P P++ P
Sbjct: 316 HLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAP-----------PQVPP 364
Query: 415 ADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDS 474
+Y P M E + +++ K L + GG D
Sbjct: 365 T----------------RYSP--IPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDG 406
Query: 475 PIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWID 534
+ VS + G A+ G + +GD I+++NG + + T +A AAL++A
Sbjct: 407 E--GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS-----V 459
Query: 535 LVVAVCPPKEY 545
+VA P+EY
Sbjct: 460 TIVAQYRPEEY 470
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 72.4 bits (176), Expect = 1e-12
Identities = 74/272 (27%), Positives = 121/272 (44%), Gaps = 61/272 (22%)
Query: 95 PEGLGLSVRGG-----LEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHE 148
P+GLG S+ GG + ++++ +I GG A G LQVGD ++ +N YS+ THE
Sbjct: 149 PKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 208
Query: 149 EVINLIR-TKKTVSIKV--------------------------RHI-----GLIPVKSS- 175
E + +++ T + V +KV H+ G + K+S
Sbjct: 209 EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSL 268
Query: 176 -PDEPLTWQYV-------DQFVSESGGVRG------SLGSPGNRENKEKKVFISLVGSRG 221
P P + + D + S S +L + E + +KV + GS G
Sbjct: 269 PPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLH-KGSTG 327
Query: 222 LGCSISSGPIQKPGIFISHV---KPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVL 278
LG +I G GIF+S + P LS E L+ GDQI+ VNG+D H++A L
Sbjct: 328 LGFNIVGGE-DGEGIFVSFILAGGPADLSGE--LQRGDQILSVNGIDLRGASHEQAAAAL 384
Query: 279 KSSRSLTISIVAAAGRELFMTDRERLAEARQR 310
K + T++I+A E + ++ + R++
Sbjct: 385 KGA-GQTVTIIAQYQPEDYARFEAKIHDLREQ 415
Score = 56.2 bits (134), Expect = 8e-08
Identities = 60/231 (25%), Positives = 104/231 (45%), Gaps = 53/231 (22%)
Query: 84 KLKEVRLDRLHPEGLGLSVRGGLEF-----GCGLFISHLIKGGQADSVG-LQVGDEIVRI 137
+ +E+ L+R + GLG S+ GG + G+FI+ +I GG A G L+V D I+R+
Sbjct: 44 EFEEITLERGN-SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRV 102
Query: 138 NGYSISSCTHEEVINLIRTKKT-VSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVR 196
N +S +H + + ++ + V + VR
Sbjct: 103 NEVDVSEVSHSKAVEALKEAGSIVRLYVRR------------------------------ 132
Query: 197 GSLGSPGNRENKEKKVFISLV-GSRGLGCSISSGPIQK--PG---IFISHVKPGSLSAEV 250
R E V I L G +GLG SI+ G + PG I+++ + G + +
Sbjct: 133 -------RRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKD 185
Query: 251 G-LEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 300
G L++GD+++ VN + H+EAV +LK++ S + + ++MTD
Sbjct: 186 GRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT-SEVVYLKVGKPTTIYMTD 235
Score = 32.0 bits (71), Expect = 1.5
Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 450 GKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKI 509
G+ +++ K L + GG D + VS + G A+ G + +GD+I+++NG
Sbjct: 314 GEPRKVVLHKGSTGLGFNIVGGEDGE--GIFVSFILAGGPADLSGELQRGDQILSVNGID 371
Query: 510 VTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEY 545
+ + +A AAL +G ++A P++Y
Sbjct: 372 LRGASHEQAAAAL-----KGAGQTVTIIAQYQPEDY 402
Score = 30.8 bits (68), Expect = 3.4
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 4/75 (5%)
Query: 453 VRLLRIKKEGSLDLALEGGVDSPI----GKVVVSAVYERGAAERHGGIVKGDEIMAINGK 508
V + K L ++ GGV + + V+ + + GAA++ G + GD ++ +N
Sbjct: 141 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 200
Query: 509 IVTDYTLAEAEAALQ 523
+ + T EA A L+
Sbjct: 201 SLEEVTHEEAVAILK 215
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 71.6 bits (174), Expect = 2e-12
Identities = 75/244 (30%), Positives = 119/244 (48%), Gaps = 39/244 (15%)
Query: 55 RLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFI 114
RL L+ R P K + D LT + L + +GLGLS+ G G+F+
Sbjct: 1705 RLTLY---RDEAPYKEEEVCDTLT---------IELQKKPGKGLGLSIVGKRN-DTGVFV 1751
Query: 115 SHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVK 173
S ++KGG AD+ G L GD+I+ +NG + + T E V L++ + G +
Sbjct: 1752 SDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSE---------GSL--- 1799
Query: 174 SSPDEPLTWQYVDQFVSESGGVRGSLGSP--GNRENKEKKVFISLVGSRGLGCSISSG-- 229
SS PL+ + + ES + +L S G R + KK + LG SI+ G
Sbjct: 1800 SSFTFPLSGSSTSESL-ESSSKKNALASEIQGLRTVEMKKG-----PTDSLGISIAGGVG 1853
Query: 230 -PIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLK-SSRSLTI 286
P+ IFI+ + P ++A+ L +GD+IV + G + H +AVN+LK +S S+ +
Sbjct: 1854 SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM 1913
Query: 287 SIVA 290
+VA
Sbjct: 1914 QVVA 1917
Score = 65.9 bits (159), Expect = 9e-11
Identities = 77/354 (21%), Positives = 149/354 (42%), Gaps = 66/354 (18%)
Query: 98 LGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIRT 156
LG++V + G G+ + +I GG G + +GD I+ IN S S T+ + ++R
Sbjct: 1018 LGMTVSANKD-GLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRR 1076
Query: 157 KKTVSIKVRHIGLIPVKSSPDEPLTW-------QYVDQFVSESGGVRGSLGSPGNRENKE 209
+ ++ I +P + + ++ +D F S +G L E +E
Sbjct: 1077 HSLIGPDIK-ITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEE 1135
Query: 210 ------------------------KKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGS 245
K + IS+VG RG+G +S+G + + GIFI HV S
Sbjct: 1136 SELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMR-GIFIKHVLEDS 1194
Query: 246 LSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERL 304
+ + G L+ GD+IVEV+G+D + H++AV ++ + + + +V + + R+
Sbjct: 1195 PAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV----QSIINRPRKSP 1250
Query: 305 AEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKE--------------IAQKAA 350
+ L + +S +I ++ + + E A+ +
Sbjct: 1251 LPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGS 1310
Query: 351 EENERYRKEMEQIVEEEEKFKKQWE---EDWGSKEQLLLPKTITAEVHPVPLRK 401
+ + ++ Q V++E++F W+ E +G T+T E+H + L K
Sbjct: 1311 DHTQSSASKISQDVDKEDEFGYSWKNIRERYG---------TLTGELHMIELEK 1355
Score = 64.7 bits (156), Expect = 2e-10
Identities = 61/215 (28%), Positives = 101/215 (46%), Gaps = 16/215 (7%)
Query: 85 LKEVRLDRLHPEGLGLSVRGGLEFGCG---LFISHLIKGG-QADSVGLQVGDEIVRINGY 140
L+ V + + + LG+S+ GG+ G +FI+ + G A + L+VGD IV I G
Sbjct: 1831 LRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGT 1890
Query: 141 SISSCTHEEVINLIRTKK-TVSIKVRHIGLIPVKSS-PDEPLTWQYVDQFVSESGGVRGS 198
S TH + +NL++ ++ ++V G + V + EP + ++ S +
Sbjct: 1891 STEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDD 1950
Query: 199 LGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKP----GSLSAEVGLEI 254
LG P + ++ G GLG SI G G +VK G+ S + L+
Sbjct: 1951 LGPPQCKSITLER------GPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKR 2004
Query: 255 GDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
GDQI+ VNG + H+EAV +LK ++ +V
Sbjct: 2005 GDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 57.8 bits (138), Expect = 3e-08
Identities = 54/188 (28%), Positives = 78/188 (41%), Gaps = 33/188 (17%)
Query: 97 GLGLSVRGGLEFGCGLFISHLI--KGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLI 154
GLGLS+ GG + G I H + +G L GD+I+ +NG + TH+E IN++
Sbjct: 1638 GLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVL 1697
Query: 155 RTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFI 214
R +P Y D+ + V +L + +
Sbjct: 1698 R------------------QTPQRVRLTLYRDEAPYKEEEVCDTL-----------TIEL 1728
Query: 215 SLVGSRGLGCSISSGPIQKPGIFISH-VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKE 273
+GLG SI G G+F+S VK G A+ L GDQI+ VNG D N +
Sbjct: 1729 QKKPGKGLGLSI-VGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEA 1787
Query: 274 AVNVLKSS 281
+LK S
Sbjct: 1788 VAALLKVS 1795
Score = 52.0 bits (123), Expect = 1e-06
Identities = 64/307 (20%), Positives = 130/307 (42%), Gaps = 36/307 (11%)
Query: 97 GLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR 155
GLG + GG G+ + ++ GG AD G L GD I++I ++ + E+V ++R
Sbjct: 266 GLGFGIIGGK--ATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323
Query: 156 TKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLG-SPGNRENKEKKVF- 213
+ L+ + + +E + +S S L ++ +E + F
Sbjct: 324 QCGN------RVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFD 377
Query: 214 ISLVGS-RGLGCSISS----GPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFS 267
+ L + +GLG +I+ ++ GIF+ + S G ++IGDQI+ V+G +
Sbjct: 378 VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
Query: 268 NLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMES 327
+++AV VL+ + G+ + +T R + + R+++ L+ +
Sbjct: 438 GFTNQQAVEVLRHT-----------GQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVN 486
Query: 328 NKILQEQQEMERQ-----RRKEIAQKAAEENERYRKEMEQIVE---EEEKFKKQWEEDWG 379
I++E E + R I E E+E+I + +E +W+ G
Sbjct: 487 ASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMG 546
Query: 380 SKEQLLL 386
++++
Sbjct: 547 INYEIVV 553
Score = 48.9 bits (115), Expect = 1e-05
Identities = 55/203 (27%), Positives = 81/203 (39%), Gaps = 39/203 (19%)
Query: 111 GLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIRTKK-TVSIKVRHIG 168
G+ I L + G A + G L+VGD+I+ ++ + E+ I+L++T K TV + +
Sbjct: 1505 GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIH--- 1561
Query: 169 LIPVKSSPDEPLTWQYVDQFVSESGGVRGSL-----GSP------GNRENKEKKVFIS-- 215
+PD E SL GSP + +F S
Sbjct: 1562 ----AENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDP 1617
Query: 216 ---------------LVGSRGLGCSISSGPIQKPGIFISH--VKPGSLSAEVGLEIGDQI 258
G GLG SI G G I H + G+ + L GDQI
Sbjct: 1618 ATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQI 1677
Query: 259 VEVNGVDFSNLDHKEAVNVLKSS 281
+EVNG+D H EA+NVL+ +
Sbjct: 1678 LEVNGIDLRKATHDEAINVLRQT 1700
Score = 43.5 bits (101), Expect = 5e-04
Identities = 23/66 (34%), Positives = 38/66 (57%)
Query: 459 KKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEA 518
K L L++ GG D+ +G +++ VYE GAA + G + GD+I+ +NG + T EA
Sbjct: 1634 KGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEA 1693
Query: 519 EAALQK 524
L++
Sbjct: 1694 INVLRQ 1699
Score = 43.1 bits (100), Expect = 7e-04
Identities = 57/223 (25%), Positives = 97/223 (43%), Gaps = 30/223 (13%)
Query: 97 GLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRT 156
GLG+S+ + G S L +G S L GDE++ +NG ++ H++V+N+++
Sbjct: 564 GLGISLEATV--GHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKE 621
Query: 157 KKTVSIKVRHIGLIPVKSSPD---------EPLTWQYVD--QFVSESGGVRGSLG-SPGN 204
V +P + + E +VD +F+ S L +
Sbjct: 622 LPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAG 681
Query: 205 RENKEKKVFISL-----------VGSRGLGCSISS--GPIQKPG--IFISHVKPGSLSAE 249
+ +E + +++ GS+GLG SI PI I I + PG ++ +
Sbjct: 682 QSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEK 741
Query: 250 VG-LEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAA 291
G L GD+++ VN V+ N +EAV LK + S T+ I A
Sbjct: 742 DGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVA 784
Score = 43.1 bits (100), Expect = 7e-04
Identities = 23/63 (36%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 464 LDLALEGGVDSPIGK--VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAA 521
L ++ GG SP G + V V+ +GAA G + +GD+I+A+NG+ + T EA A
Sbjct: 1968 LGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAI 2027
Query: 522 LQK 524
L++
Sbjct: 2028 LKR 2030
Score = 42.0 bits (97), Expect = 0.001
Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 10/80 (12%)
Query: 86 KEVRLDRLHPEGLGLSVRGGLEFGC---------GLFISHLIKGGQADSVG-LQVGDEIV 135
+ V L R + LG+S+ GG G G+FI H+++ A G L+ GD IV
Sbjct: 1150 RRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
Query: 136 RINGYSISSCTHEEVINLIR 155
++G + +HE+ + IR
Sbjct: 1210 EVDGMDLRDASHEQAVEAIR 1229
Score = 41.6 bits (96), Expect = 0.002
Identities = 103/486 (21%), Positives = 190/486 (39%), Gaps = 84/486 (17%)
Query: 84 KLKEVRLDRLHPEGLGLSVRGGLEFG-CGLFISHLIKGGQADSVG-LQVGDEIVRINGYS 141
+L + L++ H GLGLS+ G + +FI + G A G LQ+ DE++ ING
Sbjct: 1347 ELHMIELEKGH-SGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQI 1405
Query: 142 ISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGS 201
+ +H+ ++I K KV+ I I K + ++ V V +
Sbjct: 1406 LYGRSHQNASSII---KCAPSKVKII-FIRNKDAVNQ--------MAVCPGNAVEPLPSN 1453
Query: 202 PGNRENKEKKVFISLVGSR-------------------GLGCSISSGPIQKPGIFISHVK 242
N +NKE + ++ + GLG +IS I S +
Sbjct: 1454 SENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTE 1513
Query: 243 PGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRE 302
G + + L++GDQI+ V+ ++ +++LK+++ + A +
Sbjct: 1514 HGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSA 1573
Query: 303 RLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEI-------------AQKA 349
A + +++ Q L++ + + E I + R I +
Sbjct: 1574 AGAASGEKKNSSQSLMVPQSGSPEPESI----RNTSRSSTPAIFASDPATCPIIPGCETT 1629
Query: 350 AEENERYRKEMEQIVEEEEKF------KKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPK 403
E ++ IV + + +EE K+ L EV+ + LRK
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 404 YDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGS 463
+D+ + + T ++ + E PY E++ D + ++K+
Sbjct: 1690 HDEAINVLRQ--------TPQRVRLTLYRDEA---PYK---EEEVC--DTLTIELQKKPG 1733
Query: 464 LDLALEGGVDSPIGK-----VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEA 518
L L S +GK V VS + + G A+ G +++GD+I+ +NG+ V + T EA
Sbjct: 1734 KGLGL-----SIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT-QEA 1787
Query: 519 EAALQK 524
AAL K
Sbjct: 1788 VAALLK 1793
Score = 36.6 bits (83), Expect = 0.062
Identities = 19/80 (23%), Positives = 46/80 (57%), Gaps = 6/80 (7%)
Query: 96 EGLGLSVRGGLEFG----CGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEV 150
+GLG+++ G + G+F+ + K + G +Q+GD+I+ ++G ++ T+++
Sbjct: 385 QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 151 INLIR-TKKTVSIKVRHIGL 169
+ ++R T +TV + + G+
Sbjct: 445 VEVLRHTGQTVLLTLMRRGM 464
Score = 35.8 bits (81), Expect = 0.10
Identities = 21/76 (27%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 451 KDVRLLRIKKE-GSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKI 509
K+V+ L + K+ G L +A+ + + V++ ++ E G A G + GD+I+A++ +I
Sbjct: 1479 KNVQHLELPKDQGGLGIAISE--EDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEI 1536
Query: 510 VTDYTLAEAEAALQKA 525
V Y + + + L+ A
Sbjct: 1537 VVGYPIEKFISLLKTA 1552
Score = 33.9 bits (76), Expect = 0.40
Identities = 30/107 (28%), Positives = 49/107 (45%), Gaps = 11/107 (10%)
Query: 438 DPYSMFTPEQIMGKDVRLLRIKK--EGSLDLALEGGVDSPIGK--VVVSAVYERGAAERH 493
D + G+ V + + K G L ++ G G+ + V + E A R
Sbjct: 120 DEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRD 179
Query: 494 GGIVKGDEIMAINGKIVTDYTLAEAEA--ALQKAWNQGGDWIDLVVA 538
G + + D+I+AING+ + D T+ +A LQKA D + LV+A
Sbjct: 180 GRLKETDQILAINGQAL-DQTITHQQAISILQKA----KDTVQLVIA 221
Score = 32.0 bits (71), Expect = 1.5
Identities = 23/77 (29%), Positives = 39/77 (50%), Gaps = 4/77 (5%)
Query: 453 VRLLRIKK--EGSLDLALEGGVDSPIGKV--VVSAVYERGAAERHGGIVKGDEIMAINGK 508
+R + +KK SL +++ GGV SP+G V ++ ++ G A + + GD I+ I G
Sbjct: 1831 LRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGT 1890
Query: 509 IVTDYTLAEAEAALQKA 525
T +A L+ A
Sbjct: 1891 STEGMTHTQAVNLLKNA 1907
Score = 30.8 bits (68), Expect = 3.4
Identities = 15/54 (27%), Positives = 30/54 (55%)
Query: 472 VDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKA 525
+D +++ ++ G AE+ G ++ GD +M +N + + +L EA AL+ A
Sbjct: 721 IDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA 774
>gi|194018553 solute carrier family 9 isoform 3 regulator 2 isoform
a [Homo sapiens]
Length = 337
Score = 67.0 bits (162), Expect = 4e-11
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 37/226 (16%)
Query: 79 PRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGC-GLFISHLIKGGQADSVGLQVGDEIVRI 137
P R R + VR + +G G + G E G G FI + G A++ L+ GD +V +
Sbjct: 6 PLRPRLCRLVRGE----QGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEV 59
Query: 138 NGYSISSCTHEEVINLI---------------------RTKKTVSIKVRHIGLIPVKSSP 176
NG ++ TH +V+ I R + T + ++ GL P
Sbjct: 60 NGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPW 119
Query: 177 DEPLTWQYVDQFVSESG--GVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKP 234
+ W + SE+G V G L RE + + + G +G G ++ S +P
Sbjct: 120 EPKPDWAHTGSHSSEAGKKDVSGPL-----RELRPRLCHLRK-GPQGYGFNLHSDK-SRP 172
Query: 235 GIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
G +I V PGS +A GL D+++EVNG + L H E V +K+
Sbjct: 173 GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
Score = 48.9 bits (115), Expect = 1e-05
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 10/106 (9%)
Query: 218 GSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNV 277
G +G G + G + G FI V+PGS + L GD++VEVNGV+ H + V
Sbjct: 17 GEQGYGFHLH-GEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQR 75
Query: 278 LKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRL 323
+K+ T L + D+E E R+R+L E + Q+ L
Sbjct: 76 IKAVEGQT---------RLLVVDQETDEELRRRQLTCTEEMAQRGL 112
Score = 33.9 bits (76), Expect = 0.40
Identities = 21/81 (25%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 82 SRKLKEVRLDRLH----PEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRI 137
S L+E+R H P+G G ++ + G +I + G A GL+ D ++ +
Sbjct: 141 SGPLRELRPRLCHLRKGPQGYGFNLHSD-KSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
Query: 138 NGYSISSCTHEEVINLIRTKK 158
NG ++ H EV+ I+ ++
Sbjct: 200 NGQNVEGLRHAEVVASIKARE 220
>gi|71897229 solute carrier family 9 isoform 3 regulator 2 isoform b
[Homo sapiens]
Length = 326
Score = 67.0 bits (162), Expect = 4e-11
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 37/226 (16%)
Query: 79 PRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGC-GLFISHLIKGGQADSVGLQVGDEIVRI 137
P R R + VR + +G G + G E G G FI + G A++ L+ GD +V +
Sbjct: 6 PLRPRLCRLVRGE----QGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEV 59
Query: 138 NGYSISSCTHEEVINLI---------------------RTKKTVSIKVRHIGLIPVKSSP 176
NG ++ TH +V+ I R + T + ++ GL P
Sbjct: 60 NGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPW 119
Query: 177 DEPLTWQYVDQFVSESG--GVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKP 234
+ W + SE+G V G L RE + + + G +G G ++ S +P
Sbjct: 120 EPKPDWAHTGSHSSEAGKKDVSGPL-----RELRPRLCHLRK-GPQGYGFNLHSDK-SRP 172
Query: 235 GIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
G +I V PGS +A GL D+++EVNG + L H E V +K+
Sbjct: 173 GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
Score = 48.9 bits (115), Expect = 1e-05
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 10/106 (9%)
Query: 218 GSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNV 277
G +G G + G + G FI V+PGS + L GD++VEVNGV+ H + V
Sbjct: 17 GEQGYGFHLH-GEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQR 75
Query: 278 LKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRL 323
+K+ T L + D+E E R+R+L E + Q+ L
Sbjct: 76 IKAVEGQT---------RLLVVDQETDEELRRRQLTCTEEMAQRGL 112
Score = 33.9 bits (76), Expect = 0.40
Identities = 21/81 (25%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 82 SRKLKEVRLDRLH----PEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRI 137
S L+E+R H P+G G ++ + G +I + G A GL+ D ++ +
Sbjct: 141 SGPLRELRPRLCHLRKGPQGYGFNLHSD-KSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
Query: 138 NGYSISSCTHEEVINLIRTKK 158
NG ++ H EV+ I+ ++
Sbjct: 200 NGQNVEGLRHAEVVASIKARE 220
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 65.9 bits (159), Expect = 9e-11
Identities = 64/230 (27%), Positives = 106/230 (46%), Gaps = 29/230 (12%)
Query: 88 VRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCT 146
V L + GLGLS+ G G G+FIS ++KGG AD G L GD+I+ +NG + + +
Sbjct: 1534 VDLQKKAGRGLGLSIVGKRN-GSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNAS 1592
Query: 147 HEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVD------------QFVSESGG 194
E V +++ + + IG + S T Q F G
Sbjct: 1593 QETVATILKCAQ--GLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITG 1650
Query: 195 VRGSLGS-----PGNREN----KEKKVFISLVGSRGLGCSISSG---PIQKPGIFISHVK 242
++ +G+ P + + + + V I+ S LG SI+ G P+ +FI+ ++
Sbjct: 1651 LQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQ 1710
Query: 243 PGSLSAEV-GLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAA 291
++A L++GD+IV +NG L H + VN+LK++ I V A
Sbjct: 1711 ASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVA 1760
Score = 65.5 bits (158), Expect = 1e-10
Identities = 101/477 (21%), Positives = 188/477 (39%), Gaps = 98/477 (20%)
Query: 98 LGLSVRGG------LEFG---CGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTH 147
LG+S+ GG L+ G G+FI +++ A L+ GD+I+ ++G + + +H
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138
Query: 148 EEVINLIRTK-KTVSIKVRHIG----LIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSP 202
E + I+ V V+ + +IP + +T + +G+ P
Sbjct: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198
Query: 203 ------------GNRENKEKKVFIS---------LVGS----------RGLGCSISSGPI 231
+ EN+E+ F L G GLG S++
Sbjct: 1199 MKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKD 1258
Query: 232 Q-KPGIFISHVKP-GSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
+ + IF+ + P G +A+ + IGD+++E+N H+ A ++K++ S
Sbjct: 1259 RSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS------ 1312
Query: 290 AAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKA 349
+ +L R + Q + + S +++Q E +
Sbjct: 1313 -----------KVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTE--------PIS 1353
Query: 350 AEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVE 409
+EE+ ++Q+ E E FK + +Q P ++ +PL
Sbjct: 1354 SEEDGSVEVGIKQL-PESESFKLAVSQ----MKQQKYPTKVSFSSQEIPLA--------- 1399
Query: 410 PELEPADDLDGGTEEQGEQDFRKYEEGFDPYSM--FTPEQIMGKDVRLLRIKKEGSLDLA 467
PA + DF Y P S+ T + G+++ + K L L+
Sbjct: 1400 ----PASSY-----HSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLS 1450
Query: 468 LEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQK 524
+ GG D+P+ +V+ VYE GAA R G + GD+I+ +NG + + + EA AL++
Sbjct: 1451 IVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQ 1507
Score = 62.0 bits (149), Expect = 1e-09
Identities = 74/317 (23%), Positives = 133/317 (41%), Gaps = 27/317 (8%)
Query: 97 GLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR 155
GLG + GG G+ + ++ GG AD G LQ GD I++I G ++ T E+V ++R
Sbjct: 257 GLGFGIVGGKT--SGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314
Query: 156 T-KKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESG-GVRGSLGSPGNRENKEKKVF 213
+V + V + +P P V+ G G SL N E K
Sbjct: 315 NCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDG- 373
Query: 214 ISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHK 272
+G R +G +S + GI++ + PGS + G +++ D+IV V+GV+ +
Sbjct: 374 -QSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 273 EAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQ-------ELLMQKRLAM 325
+ V VL++ AG+ + +T R + L+ E L L +
Sbjct: 433 DVVEVLRN-----------AGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFL 481
Query: 326 ESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEE-EEKFKKQWEEDWGSKEQL 384
+ + E + KE +N + +++E++ + E + K +WE G ++
Sbjct: 482 TGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEV 541
Query: 385 LLPKTITAEVHPVPLRK 401
++ T L+K
Sbjct: 542 MVATLDTQIADDAELQK 558
Score = 58.2 bits (139), Expect = 2e-08
Identities = 59/193 (30%), Positives = 83/193 (43%), Gaps = 37/193 (19%)
Query: 97 GLGLSVRGGLEFGCGLFISHLI--KGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLI 154
GLGLS+ GG + + H + +G A L GD+I+ +NG + + +HEE I +
Sbjct: 1446 GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505
Query: 155 R-TKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKE-KKV 212
R T + V + V DE Y D+ EN E V
Sbjct: 1506 RQTPQKVRLVVYR----------DEA---HYRDE------------------ENLEIFPV 1534
Query: 213 FISLVGSRGLGCSISSGPIQKPGIFISH-VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDH 271
+ RGLG SI G G+FIS VK G+ + L GDQI+ VNG D N
Sbjct: 1535 DLQKKAGRGLGLSI-VGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1593
Query: 272 KEAVNVLKSSRSL 284
+ +LK ++ L
Sbjct: 1594 ETVATILKCAQGL 1606
Score = 47.0 bits (110), Expect = 5e-05
Identities = 31/107 (28%), Positives = 54/107 (50%), Gaps = 4/107 (3%)
Query: 53 PSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCG- 111
PS P+ ++ L+ K + Q + + V ++R + LG+S+ GG G
Sbjct: 1642 PSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGD 1701
Query: 112 --LFISHLIKGG-QADSVGLQVGDEIVRINGYSISSCTHEEVINLIR 155
+FI+ + G A + L+VGD IV ING + +H +V+NL++
Sbjct: 1702 IPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLK 1748
Score = 46.6 bits (109), Expect = 6e-05
Identities = 55/211 (26%), Positives = 86/211 (40%), Gaps = 25/211 (11%)
Query: 86 KEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGL-QVGDEIVRINGYSISS 144
K +L +H LG+ V F +IS ++ GG D++GL Q DE++ +NG +
Sbjct: 558 KYSKLLPIHTLRLGVEVDS---FDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYG 614
Query: 145 CTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQY----------VDQFVSESGG 194
+ E ++ ++ V L ++S DEP + +D E
Sbjct: 615 KSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDD 674
Query: 195 VRGSLGSPGNRENKEKKVFISLVGSRGLGCSISS-----GPIQKPGIFISHVKPGSLSAE 249
+L SP E K+ + +GLG SI P + + S V G
Sbjct: 675 GELALWSP------EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERS 728
Query: 250 VGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
GL GD++V VN N EAV +LK+
Sbjct: 729 GGLLPGDRLVSVNEYCLDNTSLAEAVEILKA 759
Score = 44.3 bits (103), Expect = 3e-04
Identities = 25/66 (37%), Positives = 35/66 (53%), Gaps = 2/66 (3%)
Query: 218 GSRGLGCSISSGPIQKPGIFISH--VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAV 275
G GLG SI G + H + G+ + + L GDQI+EVNGVD N H+EA+
Sbjct: 1443 GRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAI 1502
Query: 276 NVLKSS 281
L+ +
Sbjct: 1503 TALRQT 1508
Score = 40.4 bits (93), Expect = 0.004
Identities = 41/150 (27%), Positives = 72/150 (48%), Gaps = 21/150 (14%)
Query: 401 KPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLR-IK 459
+P+ + PE E ++D TEE + + ++++PE K V L++ K
Sbjct: 648 EPRRTETSLPETEVDHNMDVNTEEDDDGEL----------ALWSPEV---KIVELVKDCK 694
Query: 460 KEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAE 519
G L + +D +V+ ++ G AER GG++ GD ++++N + + +LAEA
Sbjct: 695 GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAV 754
Query: 520 AALQKAWNQGGDWIDLV-VAVCPPKEYDDE 548
L KA G LV + +C P D+E
Sbjct: 755 EIL-KAVPPG-----LVHLGICKPLVEDNE 778
Score = 33.9 bits (76), Expect = 0.40
Identities = 23/79 (29%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 454 RLLRIKKEGS--LDLALEGGVDSPIGK--VVVSAVYERGAAERHGGIVKGDEIMAINGKI 509
R + I +E S L +++ GG SP+G V ++ + G A R + GD I++ING+
Sbjct: 1675 RTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQP 1734
Query: 510 VTDYTLAEAEAALQKAWNQ 528
+ + A+ L+ A+ +
Sbjct: 1735 LDGLSHADVVNLLKNAYGR 1753
Score = 32.3 bits (72), Expect = 1.2
Identities = 25/84 (29%), Positives = 36/84 (42%), Gaps = 4/84 (4%)
Query: 445 PEQIMGKDVRLLRIKKEGS-LDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIM 503
PE + V + + +GS L + GG S VVV + G A+R G + GD I+
Sbjct: 238 PETVCWGHVEEVELINDGSGLGFGIVGGKTSG---VVVRTIVPGGLADRDGRLQTGDHIL 294
Query: 504 AINGKIVTDYTLAEAEAALQKAWN 527
I G V T + L+ N
Sbjct: 295 KIGGTNVQGMTSEQVAQVLRNCGN 318
Score = 31.2 bits (69), Expect = 2.6
Identities = 11/30 (36%), Positives = 23/30 (76%)
Query: 479 VVVSAVYERGAAERHGGIVKGDEIMAINGK 508
V +S + + GAA+ G +++GD+I+++NG+
Sbjct: 1557 VFISDIVKGGAADLDGRLIQGDQILSVNGE 1586
Score = 30.0 bits (66), Expect = 5.8
Identities = 18/62 (29%), Positives = 34/62 (54%), Gaps = 2/62 (3%)
Query: 97 GLGLSVRGGLEFG-CGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLI 154
GLGLS+ G + +F+ + G A + G +++GDE++ IN + +H+ +I
Sbjct: 1248 GLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAII 1307
Query: 155 RT 156
+T
Sbjct: 1308 KT 1309
>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
Length = 358
Score = 63.5 bits (153), Expect = 5e-10
Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 34/228 (14%)
Query: 95 PEGLGLSVRGGLEFG-CGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINL 153
P G G + G E G G +I + G A+ GL GD +V +NG ++ TH++V++
Sbjct: 21 PNGYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSR 78
Query: 154 IRTK-----------------KTVSIKVRHIGLIPVKSSPD--EPLTWQYVDQFVSESGG 194
IR + + ++VR L+ + +P EP V +E+
Sbjct: 79 IRAALNAVRLLVVDPETDEQLQKLGVQVRE-ELLRAQEAPGQAEPPAAAEVQGAGNENEP 137
Query: 195 VRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEI 254
P RE + + + G G G ++ S KPG FI V P S + GL
Sbjct: 138 READKSHPEQRELRPRLCTMKK-GPSGYGFNLHSDK-SKPGQFIRSVDPDSPAEASGLRA 195
Query: 255 GDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRE 302
D+IVEVNGV H + V+ +++ T +L + DRE
Sbjct: 196 QDRIVEVNGVCMEGKQHGDVVSAIRAGGDET---------KLLVVDRE 234
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 63.2 bits (152), Expect = 6e-10
Identities = 70/286 (24%), Positives = 128/286 (44%), Gaps = 24/286 (8%)
Query: 96 EGLGLSVRGGLE--FG-CGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVI 151
+GLG S+ GG + +G G+++ + GG A + G LQ GDEI+ +NG S++ TH++ +
Sbjct: 225 KGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDAL 284
Query: 152 NLIRTKK----TVSIKVR---------HIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGS 198
+ K T++++ R H+ +S + F ES S
Sbjct: 285 QKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPIS 344
Query: 199 LGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQK--PGIFISHVKPGSLSAEVG-LEIG 255
P R E V + GLG + S P + GIF+ + PGS++ G L G
Sbjct: 345 TAKPNYRIMVE--VSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCG 402
Query: 256 DQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQ 315
D+IVE++ L E +L + I+ + + +++ ++L EA + ++
Sbjct: 403 DEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE-QQLKEAVAQAVENT 461
Query: 316 ELLMQK-RLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 360
+ ++ + ++E K L+ KE + +A + R +K M
Sbjct: 462 KFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVM 507
Score = 50.8 bits (120), Expect = 3e-06
Identities = 53/219 (24%), Positives = 98/219 (44%), Gaps = 21/219 (9%)
Query: 83 RKLKEVRLDRLHPE---GLGLSVRGGLEFGCGLFISHLI-KGGQADSVG-LQVGDEIVRI 137
++L + + LH E GLG S+ GG + + H + G A G +Q G+E++ I
Sbjct: 1106 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 1165
Query: 138 NGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRG 197
NG S+ TH + + ++R + + R ++ K +P+ D S
Sbjct: 1166 NGKSLKGTTHHDALAILRQAR----EPRQAVIVTRKLTPE-----AMPDLNSSTDSAASA 1216
Query: 198 SLGSPGNRENKEKKVFISLV---GSRGLGCSISSGPIQKPG---IFISHVKPGSLSAE-V 250
S S + E+ + ++ S GLG S+ G G + I+ + G+ S +
Sbjct: 1217 SAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSE 1276
Query: 251 GLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
++ GD+I+++ G L EA N++K+ ++IV
Sbjct: 1277 TVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIV 1315
Score = 50.4 bits (119), Expect = 4e-06
Identities = 37/131 (28%), Positives = 64/131 (48%), Gaps = 9/131 (6%)
Query: 403 KYDQGVEPELEPADDLDGGTEEQGE--------QDFRKYEEGFDPYSMFTPEQIMGKDVR 454
+Y +G+ E + DD D + + G+ ++ +K E T +Q+ G V
Sbjct: 1056 EYTEGLT-EAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVT 1114
Query: 455 LLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYT 514
+L ++ L +L GG D + V V+ G A + G I KG+E+++INGK + T
Sbjct: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
Query: 515 LAEAEAALQKA 525
+A A L++A
Sbjct: 1175 HHDALAILRQA 1185
Score = 42.0 bits (97), Expect = 0.001
Identities = 33/108 (30%), Positives = 57/108 (52%), Gaps = 15/108 (13%)
Query: 187 QFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGP--IQKP-GIFISHVKP 243
Q V SGG++ S+ S + + ++GLG SI G I P GI++ +
Sbjct: 201 QLVQPSGGLQASVIS---------NIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFA 251
Query: 244 GSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRS--LTISI 288
G +A G L+ GD+I+E+NG + L H++A+ K ++ LT+++
Sbjct: 252 GGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTV 299
Score = 36.2 bits (82), Expect = 0.080
Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 4/65 (6%)
Query: 464 LDLALEGGVDS---PIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEA 520
L ++ GG DS PIG + V ++ GAA G + +GDEI+ +NG+ + T +A
Sbjct: 227 LGFSIVGGKDSIYGPIG-IYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 285
Query: 521 ALQKA 525
++A
Sbjct: 286 KFKQA 290
Score = 30.4 bits (67), Expect = 4.4
Identities = 18/62 (29%), Positives = 31/62 (50%), Gaps = 2/62 (3%)
Query: 459 KKEGSLDLALEGGVDSPIGK--VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLA 516
K L +LEGG S G + ++ +++ A+E+ + GDEI+ + G + T
Sbjct: 1239 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRF 1298
Query: 517 EA 518
EA
Sbjct: 1299 EA 1300
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 60.8 bits (146), Expect = 3e-09
Identities = 55/201 (27%), Positives = 96/201 (47%), Gaps = 15/201 (7%)
Query: 96 EGLGLSVRGG---LEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVI 151
EGLG S+ + +++ +++ G A G L+ GD ++ +NG + + EEV+
Sbjct: 469 EGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVV 528
Query: 152 NLIRTKK---TVSIKV-RHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNREN 207
+L+R+ K TVS+ V R + EP Q + +E + L G RE
Sbjct: 529 SLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDI--VLTPDGTREF 586
Query: 208 KEKKVFISLVGSRGLGCSISSGPIQKP----GIFI-SHVKPGSLSAEVGLEIGDQIVEVN 262
+V ++ GS GLG S+ ++ GIF+ S + G+ S + L + DQ++ VN
Sbjct: 587 LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVN 646
Query: 263 GVDFSNLDHKEAVNVLKSSRS 283
G +++A+ L+ S S
Sbjct: 647 GESLLGKTNQDAMETLRRSMS 667
Score = 48.1 bits (113), Expect = 2e-05
Identities = 37/124 (29%), Positives = 69/124 (55%), Gaps = 7/124 (5%)
Query: 198 SLGSPGNRENKEKKVFISLV-GSRGLGCSISSGPIQKPG---IFISHVKPGSLSAEVG-L 252
++ S N + K++ I L G+ GLG SI+S + G I++ ++ P + + G L
Sbjct: 446 TVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRL 505
Query: 253 EIGDQIVEVNGVDFSNLDHKEAVNVLKSSR-SLTISIVAAAGRELFMTDRERLAEARQRE 311
+ GD+++EVNGVD +E V++L+S++ T+S++ + F RE AE Q +
Sbjct: 506 KAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAF-HPRELNAEPSQMQ 564
Query: 312 LQRQ 315
+ ++
Sbjct: 565 IPKE 568
Score = 31.2 bits (69), Expect = 2.6
Identities = 17/63 (26%), Positives = 35/63 (55%), Gaps = 3/63 (4%)
Query: 479 VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGD---WIDL 535
+ V ++ GAA + G + D+++A+NG+ + T +A L+++ + G+ I L
Sbjct: 619 IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQL 678
Query: 536 VVA 538
+VA
Sbjct: 679 IVA 681
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 60.5 bits (145), Expect = 4e-09
Identities = 110/484 (22%), Positives = 182/484 (37%), Gaps = 57/484 (11%)
Query: 63 RPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQ 122
R +P + D P K +V L R+ G G + GG E G + I +I G
Sbjct: 756 RQQVPPRTSFRMDSSGP--DYKELDVHLRRME-SGFGFRILGGDEPGQPILIGAVIAMGS 812
Query: 123 ADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR---TKKTVSIKVRHIGLIPVKSSPDE 178
AD G L GDE+V ++G ++ TH VI+L+ V++ VR L + P+
Sbjct: 813 ADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPEN 872
Query: 179 PLTWQYVDQ-----------FVSESGGVRGSLGSP----GNRENKEKKVFISLVGSRGLG 223
+ V + + + S SP + + V I + G G
Sbjct: 873 GRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFG 932
Query: 224 CSISSG---PIQKPGIFISH----VKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAV 275
I S P I + H + GS + L++GD+I+ VNG N+ H + V
Sbjct: 933 FVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIV 992
Query: 276 NVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQ 335
++K + L++++ EL +E + Q+ L Q LA S
Sbjct: 993 KLIKDA-GLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPS-------- 1043
Query: 336 EMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVH 395
IAQ A + Q+ E ++ + + K + P
Sbjct: 1044 --PATPNSPIAQPAPPQPL-------QLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQP 1094
Query: 396 PVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRL 455
P+ R+P +P P D + D+R++ Y + Q D
Sbjct: 1095 PLDYRQPPGGDYQQPP--PLD-----YRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFT 1147
Query: 456 LRIKKEGS-LDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYT 514
+ ++K ++ GG + + V+ E G A R+G + GD+I+ ING+ D T
Sbjct: 1148 VDMEKGAKGFGFSIRGGREYKMDLYVLRLA-EDGPAIRNGRMRVGDQIIEINGESTRDMT 1206
Query: 515 LAEA 518
A A
Sbjct: 1207 HARA 1210
Score = 53.1 bits (126), Expect = 6e-07
Identities = 32/90 (35%), Positives = 48/90 (53%), Gaps = 6/90 (6%)
Query: 96 EGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLI 154
+G G S+RGG E+ L++ L + G A G ++VGD+I+ ING S TH I LI
Sbjct: 1155 KGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELI 1214
Query: 155 RT--KKTVSIKVRHIGLIPVKSSPDEPLTW 182
++ ++ + R G +P DEP W
Sbjct: 1215 KSGGRRVRLLLKRGTGQVP---EYDEPAPW 1241
Score = 40.0 bits (92), Expect = 0.006
Identities = 19/64 (29%), Positives = 35/64 (54%), Gaps = 1/64 (1%)
Query: 218 GSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVN 276
G++G G SI G K +++ + + G + +GDQI+E+NG ++ H A+
Sbjct: 1153 GAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIE 1212
Query: 277 VLKS 280
++KS
Sbjct: 1213 LIKS 1216
Score = 34.7 bits (78), Expect = 0.23
Identities = 51/238 (21%), Positives = 89/238 (37%), Gaps = 60/238 (25%)
Query: 97 GLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR 155
G G ++ GG E L + +I G A G ++ GD IV IN + TH +V+ L +
Sbjct: 435 GFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQ 494
Query: 156 TKKT-VSIKVRHIGLIPVKSSPDEPLT----------------------WQYVDQFVSES 192
+ S+ + P+ P++P ++ +++S +
Sbjct: 495 SVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRT 554
Query: 193 ---------------------GGVRGSLGSPGNREN----------KEKKVFISLVGSRG 221
G + G+ P + +N E + G++G
Sbjct: 555 SQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQG 614
Query: 222 LGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLK 279
G +I+ P G + + + GL GD IVE+N + NL H E V++LK
Sbjct: 615 FGFTIADSPT---GQRVKQIL--DIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILK 667
>gi|21630285 PDZ domain containing 3 [Homo sapiens]
Length = 491
Score = 60.5 bits (145), Expect = 4e-09
Identities = 63/223 (28%), Positives = 99/223 (44%), Gaps = 27/223 (12%)
Query: 95 PEGLGLSVRG--GLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVIN 152
P+G G +R GL+ G F+ + G A G+Q GD +V + G S+ HEE ++
Sbjct: 256 PQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVS 315
Query: 153 LIRTKKT-VSIKV------RHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNR 205
I+ + + VS+ V R + V+ SP L + + S G SL +
Sbjct: 316 RIQGQGSCVSLTVVDPEADRFFSM--VRLSP--LLFLENTEAPASPQGSSSASLVETEDP 371
Query: 206 ENKEKKVFISLVGSRGLGCSISSGP-----------IQKPGIFISHVKPGSLSAEVGLEI 254
++ V +GSR C + GP P +FIS V PG +A GL++
Sbjct: 372 SLEDTSVPSVPLGSRQ--CFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQV 429
Query: 255 GDQIVEVNGVDFSNLDHKEAVNVL-KSSRSLTISIVAAAGREL 296
GD I+EVNG + E + L ++ L + + A + R L
Sbjct: 430 GDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKLAARSLRGL 472
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 60.1 bits (144), Expect = 5e-09
Identities = 48/179 (26%), Positives = 81/179 (45%), Gaps = 16/179 (8%)
Query: 111 GLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLI 170
G++++ + G A G+ D ++ +NG ++ +HEEV+ + KK+ S + +
Sbjct: 157 GVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVE--KVKKSGS----RVMFL 210
Query: 171 PVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGP 230
V D+ Q + QF E+ ++ P E K+ GS G G + +G
Sbjct: 211 LVDKETDKRHVEQKI-QFKRETASLKLLPHQPRIVEMKK--------GSNGYGFYLRAGS 261
Query: 231 IQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIV 289
QK G I + GS + E GL+ D +V VNG LDH V +++ T +V
Sbjct: 262 EQK-GQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLV 319
Score = 54.7 bits (130), Expect = 2e-07
Identities = 53/205 (25%), Positives = 92/205 (44%), Gaps = 20/205 (9%)
Query: 94 HPEGLGLSVRGGLEFGCGLFIS-----HLI----KGGQADSVGLQVGDEIVRINGYSISS 144
+P LS + G +G L I HL+ K A+ GLQ GD ++RING +
Sbjct: 6 NPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDK 65
Query: 145 CTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSP-- 202
H +V++L+R K S+ + + + + + + + Q E G + ++ SP
Sbjct: 66 EEHMQVVDLVR-KSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQG-LSDNILSPVM 123
Query: 203 -GNRENKEKKVFISLV---GSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQI 258
G + + LV GS G G K G++++ + P ++ G+ D +
Sbjct: 124 NGGVQTWTQPRLCYLVKEGGSYGFSLKTVQG---KKGVYMTDITPQGVAMRAGVLADDHL 180
Query: 259 VEVNGVDFSNLDHKEAVNVLKSSRS 283
+EVNG + + H+E V +K S S
Sbjct: 181 IEVNGENVEDASHEEVVEKVKKSGS 205
Score = 51.6 bits (122), Expect = 2e-06
Identities = 52/223 (23%), Positives = 92/223 (41%), Gaps = 25/223 (11%)
Query: 97 GLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRT 156
G G +R G E G I + G A+ GL+ D +V +NG S+ + H+ V+ +IR
Sbjct: 252 GYGFYLRAGSEQK-GQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRK 310
Query: 157 KKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVS------ESGGVRGS----------LG 200
+ L+ V D + F+ +G V+ +
Sbjct: 311 GGDQT------SLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSS 364
Query: 201 SPGNRENKEKKVFISLVGSRGLGCSISSGPIQK-PGIFISHVKPGSLSAEVGLEIGDQIV 259
P E + K + + G I+ PG FI V+ G + GLE D I+
Sbjct: 365 PPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVII 424
Query: 260 EVNGVDFSNLDHKEAVNVLKSS-RSLTISIVAAAGRELFMTDR 301
EVNGV+ + +++ V+ ++SS +++T+ + + F +
Sbjct: 425 EVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKK 467
Score = 38.5 bits (88), Expect = 0.016
Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 9/79 (11%)
Query: 111 GLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTK-KTVSIKV----- 164
G FI + KGG AD GL+ D I+ +NG ++ +E+V++ I++ K V++ V
Sbjct: 400 GSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKA 459
Query: 165 ---RHIGLIPVKSSPDEPL 180
IP+ SS +PL
Sbjct: 460 YDYFQAKKIPIVSSLADPL 478
Score = 35.0 bits (79), Expect = 0.18
Identities = 22/81 (27%), Positives = 42/81 (51%), Gaps = 1/81 (1%)
Query: 235 GIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVN-VLKSSRSLTISIVAAAG 293
G + V+ S + + GL+ GD+++ +NGV +H + V+ V KS S+T+ ++
Sbjct: 32 GHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDS 91
Query: 294 RELFMTDRERLAEARQRELQR 314
E + R L E Q + ++
Sbjct: 92 YEKAVKTRVDLKELGQSQKEQ 112
>gi|7706025 PDZ domain containing 11 [Homo sapiens]
Length = 140
Score = 60.1 bits (144), Expect = 5e-09
Identities = 28/67 (41%), Positives = 45/67 (67%)
Query: 222 LGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSS 281
LG +I G + GIFIS V P S + GL+ GDQ++ VN VDF +++H +AV +LK++
Sbjct: 58 LGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTA 117
Query: 282 RSLTISI 288
R +++ +
Sbjct: 118 REISMRV 124
Score = 53.9 bits (128), Expect = 4e-07
Identities = 29/111 (26%), Positives = 55/111 (49%), Gaps = 1/111 (0%)
Query: 56 LPLFDAIRPLIPLKHQVEYDQLTPRRSRKL-KEVRLDRLHPEGLGLSVRGGLEFGCGLFI 114
LP ++ IP +V + ++ L + + L + LG ++RGG G+FI
Sbjct: 15 LPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFI 74
Query: 115 SHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVR 165
S +I A GLQ GD+++ +N H + + +++T + +S++VR
Sbjct: 75 SKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVR 125
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 58.5 bits (140), Expect = 2e-08
Identities = 72/317 (22%), Positives = 131/317 (41%), Gaps = 61/317 (19%)
Query: 97 GLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR 155
G G + GG E G ++I H++ G AD+ G L+ GDE++ ++G + +H+ V+ L++
Sbjct: 822 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 881
Query: 156 ---TKKTVSIKVRHIGLIPVKSSPDE-----------------------PLTWQYVDQFV 189
+ V++ VR + V + +E P Q V
Sbjct: 882 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTV 941
Query: 190 SESGGVRGSLGSPGN-----------------RENKEKK---VFISLVGSRGLGCSISSG 229
S G +GS G R + + V +S V G + +
Sbjct: 942 SSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNA 1001
Query: 230 PIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLK-SSRSLTIS 287
+ P I + GS + G L++GD+I+ VNG +N H + VN++K + ++T+
Sbjct: 1002 CVAMPH-KIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLR 1060
Query: 288 IVAA--AGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEI 345
I+ + +T+ E++A Q+ + R + K QE Q +
Sbjct: 1061 IIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETR---NTTKPKQESQFEFK------ 1111
Query: 346 AQKAAEENERYRKEMEQ 362
A +A +E + Y E+E+
Sbjct: 1112 APQATQEQDFYTVELER 1128
Score = 58.2 bits (139), Expect = 2e-08
Identities = 44/185 (23%), Positives = 84/185 (45%), Gaps = 19/185 (10%)
Query: 114 ISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR-TKKTVSIKV------- 164
I +I+G AD G L+VGD I+ +NG SI++ +H +++NLI+ TV++++
Sbjct: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESS 1068
Query: 165 --------RHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISL 216
I I +P + T Q + +P + ++
Sbjct: 1069 NATLLTNAEKIATITTTHTPSQQGT-QETRNTTKPKQESQFEFKAPQATQEQDFYTVELE 1127
Query: 217 VGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAV 275
G++G G S+ G +++ + + G + IGD+I+E+NG N+ H A+
Sbjct: 1128 RGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAI 1187
Query: 276 NVLKS 280
++K+
Sbjct: 1188 ELIKN 1192
Score = 50.1 bits (118), Expect = 5e-06
Identities = 28/86 (32%), Positives = 46/86 (53%), Gaps = 2/86 (2%)
Query: 71 QVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQ 129
Q E+ + + V L+R +G G S+RGG E+ L++ L + G A+ G ++
Sbjct: 1107 QFEFKAPQATQEQDFYTVELER-GAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMR 1165
Query: 130 VGDEIVRINGYSISSCTHEEVINLIR 155
+GDEI+ ING + + H I LI+
Sbjct: 1166 IGDEILEINGETTKNMKHSRAIELIK 1191
Score = 38.5 bits (88), Expect = 0.016
Identities = 54/231 (23%), Positives = 88/231 (38%), Gaps = 44/231 (19%)
Query: 92 RLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEV 150
R G G +V GG E L I L+ G A G ++ GD IV +N + TH +V
Sbjct: 476 RKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQV 535
Query: 151 INLIRTKKT-VSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGV----RGSLGSPGNR 205
+ + ++ S+ + P+ PD+P T + + + + + SP +
Sbjct: 536 VKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASH 595
Query: 206 ENKEKKV------------FISLVGSRGL---GCSISSGPIQKPGIFISHV--------- 241
+K KV ++ S G S++S +P + H+
Sbjct: 596 SSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGF 655
Query: 242 ----KPGSLSAEV----------GLEIGDQIVEVNGVDFSNLDHKEAVNVL 278
PG V GL+ GD IVEVN + L H + V++L
Sbjct: 656 TIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDML 706
Score = 36.6 bits (83), Expect = 0.062
Identities = 40/197 (20%), Positives = 77/197 (39%), Gaps = 38/197 (19%)
Query: 327 SNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLL 386
+ K E +E +R+K++ Q+ ++ ++ +++ +Q ++Q E+W L+
Sbjct: 382 NRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQ--------QQQQTEEWTEDHSALV 433
Query: 387 PKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPE 446
P I HP EPA ++ QG+ P+ P
Sbjct: 434 PPVIPN--HP------------PSNPEPAREV----PLQGK-----------PFFTRNPS 464
Query: 447 QIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAIN 506
++ GK + K + GG D P + + ++ G A G + GD I+++N
Sbjct: 465 ELKGKFIHTKLRKSSRGFGFTVVGG-DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVN 523
Query: 507 GKIVTDYTLAEAEAALQ 523
V +T A+ Q
Sbjct: 524 DTCVLGHTHAQVVKIFQ 540
Score = 35.0 bits (79), Expect = 0.18
Identities = 42/205 (20%), Positives = 79/205 (38%), Gaps = 50/205 (24%)
Query: 127 GLQVGDEIVRINGYSISSCTHEEVINLI---RTKKTVSIKVRHIGL-IPVKSSPDEPL-- 180
GL+ GD IV +N ++ + TH +V++++ V++ V+ GL +P KS +PL
Sbjct: 679 GLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLER 738
Query: 181 ------------------------TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFI-- 214
+ Q + +F S G ++ K++
Sbjct: 739 KDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQS 798
Query: 215 -SLVGSR----------------GLGCSISSGPIQKPGIFISHVKP-GSLSAEVGLEIGD 256
S+ +R G G I G I+I H+ P G+ + L GD
Sbjct: 799 RSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGD 858
Query: 257 QIVEVNGVDFSNLDHKEAVNVLKSS 281
+++ V+G H+ V +++ +
Sbjct: 859 ELICVDGTPVIGKSHQLVVQLMQQA 883
Score = 33.9 bits (76), Expect = 0.40
Identities = 31/132 (23%), Positives = 56/132 (42%), Gaps = 8/132 (6%)
Query: 402 PKYDQGVEPELEPAD----DLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLR 457
P + V PE PA+ D + ++ F+ + + Y P+ +D+ L R
Sbjct: 760 PSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDY-QEQDIFLWR 818
Query: 458 IKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAE 517
KE + GG + P + + + GAA+ G + GDE++ ++G V +
Sbjct: 819 --KETGFGFRILGG-NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQL 875
Query: 518 AEAALQKAWNQG 529
+Q+A QG
Sbjct: 876 VVQLMQQAAKQG 887
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 58.5 bits (140), Expect = 2e-08
Identities = 72/317 (22%), Positives = 131/317 (41%), Gaps = 61/317 (19%)
Query: 97 GLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR 155
G G + GG E G ++I H++ G AD+ G L+ GDE++ ++G + +H+ V+ L++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
Query: 156 ---TKKTVSIKVRHIGLIPVKSSPDE-----------------------PLTWQYVDQFV 189
+ V++ VR + V + +E P Q V
Sbjct: 910 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTV 969
Query: 190 SESGGVRGSLGSPGN-----------------RENKEKK---VFISLVGSRGLGCSISSG 229
S G +GS G R + + V +S V G + +
Sbjct: 970 SSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNA 1029
Query: 230 PIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLK-SSRSLTIS 287
+ P I + GS + G L++GD+I+ VNG +N H + VN++K + ++T+
Sbjct: 1030 CVAMPH-KIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLR 1088
Query: 288 IVAA--AGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEI 345
I+ + +T+ E++A Q+ + R + K QE Q +
Sbjct: 1089 IIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETR---NTTKPKQESQFEFK------ 1139
Query: 346 AQKAAEENERYRKEMEQ 362
A +A +E + Y E+E+
Sbjct: 1140 APQATQEQDFYTVELER 1156
Score = 58.2 bits (139), Expect = 2e-08
Identities = 44/185 (23%), Positives = 84/185 (45%), Gaps = 19/185 (10%)
Query: 114 ISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR-TKKTVSIKV------- 164
I +I+G AD G L+VGD I+ +NG SI++ +H +++NLI+ TV++++
Sbjct: 1037 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESS 1096
Query: 165 --------RHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISL 216
I I +P + T Q + +P + ++
Sbjct: 1097 NATLLTNAEKIATITTTHTPSQQGT-QETRNTTKPKQESQFEFKAPQATQEQDFYTVELE 1155
Query: 217 VGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAV 275
G++G G S+ G +++ + + G + IGD+I+E+NG N+ H A+
Sbjct: 1156 RGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAI 1215
Query: 276 NVLKS 280
++K+
Sbjct: 1216 ELIKN 1220
Score = 50.1 bits (118), Expect = 5e-06
Identities = 28/86 (32%), Positives = 46/86 (53%), Gaps = 2/86 (2%)
Query: 71 QVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQ 129
Q E+ + + V L+R +G G S+RGG E+ L++ L + G A+ G ++
Sbjct: 1135 QFEFKAPQATQEQDFYTVELER-GAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMR 1193
Query: 130 VGDEIVRINGYSISSCTHEEVINLIR 155
+GDEI+ ING + + H I LI+
Sbjct: 1194 IGDEILEINGETTKNMKHSRAIELIK 1219
Score = 40.8 bits (94), Expect = 0.003
Identities = 103/494 (20%), Positives = 175/494 (35%), Gaps = 110/494 (22%)
Query: 92 RLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEV 150
R G G +V GG E L I L+ G A G ++ GD IV +N + TH +V
Sbjct: 476 RKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQV 535
Query: 151 INLIRTKKT-VSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGV----RGSLGSPGNR 205
+ + ++ S+ + P+ PD+P T + + + + + SP +
Sbjct: 536 VKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASH 595
Query: 206 ENKEKKV------------FISLVGSRGL---GCSISSGPIQKPGIFISHV--------- 241
+K KV ++ S G S++S +P + H+
Sbjct: 596 SSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGF 655
Query: 242 ----KPGSLSAEV----------GLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTIS 287
PG V GL+ GD IVEVN + L H + V++L
Sbjct: 656 TIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDML--------- 706
Query: 288 IVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQ 347
+ G E+ L+ +R + K + Q +ER+ + +Q
Sbjct: 707 VECPKGSEV--------------------TLLVQRGGLPVPKKSPKSQPLERKDSQNSSQ 746
Query: 348 KAAEENERYR----KEMEQIVEEEEKFKKQWEEDWGSKEQLLL-PKTITAEVHPVPLRKP 402
+ + Q++ E + Q + S Q P I A+ + +P
Sbjct: 747 HSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRP 806
Query: 403 KYDQGVEPELEPADDLDGGTEEQ-------GEQDFRKYEEGFDPYSMFTPEQIMGKDVRL 455
+ P PA L G E+ GE Y+E +D+ L
Sbjct: 807 -----MSP--SPASGLSKGEREREINSTNFGECPIPDYQE---------------QDIFL 844
Query: 456 LRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTL 515
R KE + GG + P + + + GAA+ G + GDE++ ++G V +
Sbjct: 845 WR--KETGFGFRILGG-NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSH 901
Query: 516 AEAEAALQKAWNQG 529
+Q+A QG
Sbjct: 902 QLVVQLMQQAAKQG 915
Score = 36.6 bits (83), Expect = 0.062
Identities = 40/197 (20%), Positives = 77/197 (39%), Gaps = 38/197 (19%)
Query: 327 SNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLL 386
+ K E +E +R+K++ Q+ ++ ++ +++ +Q ++Q E+W L+
Sbjct: 382 NRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQ--------QQQQTEEWTEDHSALV 433
Query: 387 PKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPE 446
P I HP EPA ++ QG+ P+ P
Sbjct: 434 PPVIPN--HP------------PSNPEPAREV----PLQGK-----------PFFTRNPS 464
Query: 447 QIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAIN 506
++ GK + K + GG D P + + ++ G A G + GD I+++N
Sbjct: 465 ELKGKFIHTKLRKSSRGFGFTVVGG-DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVN 523
Query: 507 GKIVTDYTLAEAEAALQ 523
V +T A+ Q
Sbjct: 524 DTCVLGHTHAQVVKIFQ 540
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 58.5 bits (140), Expect = 2e-08
Identities = 49/184 (26%), Positives = 86/184 (46%), Gaps = 17/184 (9%)
Query: 111 GLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIRTK-KTVSIKVRHIG 168
G+FI L++GG A G L D ++ ING+ + T E +I+ + V++ +
Sbjct: 363 GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR-- 420
Query: 169 LIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNREN-------KEKKVFISLVGSRG 221
P K P + S+ P + ++ +EK + +
Sbjct: 421 --PGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHES 478
Query: 222 LGCSISSGPIQKPG---IFISHVKP-GSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNV 277
LG +++ G K G IF++ V P G L+ + ++ GD ++ +NG+D +NL H EAV +
Sbjct: 479 LGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAM 538
Query: 278 LKSS 281
LK+S
Sbjct: 539 LKAS 542
Score = 47.0 bits (110), Expect = 5e-05
Identities = 52/222 (23%), Positives = 101/222 (45%), Gaps = 15/222 (6%)
Query: 86 KEVRLDRLHPEGLGLSVRGGLEFGCG---LFISHLIKGGQADSVG-LQVGDEIVRINGYS 141
K + + + E LG++V GG G +F++ + G G ++ GD ++ ING
Sbjct: 467 KHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGID 526
Query: 142 ISSCTHEEVINLIRTKKT---VSIKVRHIGLIP--VKSSPDEPLTWQYVDQFVSESGGVR 196
+++ +H E + +++ V++K + ++ +++ ++P T+ + S S
Sbjct: 527 LTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWV 586
Query: 197 GSLGSPGNRENKEKKVFI-SLVGSRGLGC--SISSGPIQKPGIFISHVKPGSLSAEVG-L 252
LG P + V S +GS G +P FI + G+ + G L
Sbjct: 587 MWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQP-FFIKTIVLGTPAYYDGRL 645
Query: 253 EIGDQIVEVNGVDFSNLDHKEAVNVLKSSRS-LTISIVAAAG 293
+ GD IV VNG+ + H V +LK R+ +T++++ G
Sbjct: 646 KCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPG 687
Score = 40.4 bits (93), Expect = 0.004
Identities = 31/123 (25%), Positives = 57/123 (46%), Gaps = 5/123 (4%)
Query: 408 VEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEG---SL 464
VE L A L +EE G D +EE + P + ++ + I + L
Sbjct: 188 VERHLTSAS-LSTWSEEPG-LDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQL 245
Query: 465 DLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQK 524
+++ GG ++P+ +V+ VY G R G ++ GD+I+ +N +++ + A A L +
Sbjct: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
Query: 525 AWN 527
N
Sbjct: 306 PCN 308
Score = 38.9 bits (89), Expect = 0.012
Identities = 46/203 (22%), Positives = 85/203 (41%), Gaps = 30/203 (14%)
Query: 98 LGLSVRGGLEFGC-GLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR 155
LG+S+ GG E + I + + G G L GD+I+++N Y+IS+ +H N R
Sbjct: 245 LGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSH----NYAR 300
Query: 156 TKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFIS 215
+ H+ ++ + G R S N +E +F
Sbjct: 301 AVLSQPCNTLHLTVLRERRF------------------GNRAHNHSDSNSPREE--IFQV 340
Query: 216 LVGSRGLGCSISSGPIQK---PGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDH 271
+ R G + +++ PG+FI + G L+A+ G L D+++ +NG D
Sbjct: 341 ALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTP 400
Query: 272 KEAVNVLKSSRSLTISIVAAAGR 294
+ A ++++S +A G+
Sbjct: 401 ELAAQIIQASGERVNLTIARPGK 423
Score = 36.2 bits (82), Expect = 0.080
Identities = 25/72 (34%), Positives = 41/72 (56%), Gaps = 4/72 (5%)
Query: 456 LRIKKEG--SLDLALEGGVDSPIGK--VVVSAVYERGAAERHGGIVKGDEIMAINGKIVT 511
+ +KKE SL + + GG S G+ + V++V G R G I +GD ++ ING +T
Sbjct: 469 ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528
Query: 512 DYTLAEAEAALQ 523
+ + +EA A L+
Sbjct: 529 NLSHSEAVAMLK 540
>gi|54633319 PDZ domain-containing guanine nucleotide exchange
factor I [Homo sapiens]
Length = 1601
Score = 58.2 bits (139), Expect = 2e-08
Identities = 30/82 (36%), Positives = 53/82 (64%), Gaps = 3/82 (3%)
Query: 225 SISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSL 284
S++ G + GIF+ V+PGS +A+ GL+ GDQI+EVNG +F N+ +AV +L+++ L
Sbjct: 545 SLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNNTHL 604
Query: 285 TISI---VAAAGRELFMTDRER 303
+++ + LF T++E+
Sbjct: 605 ALTVKTNIFVFKELLFRTEQEK 626
Score = 50.1 bits (118), Expect = 5e-06
Identities = 88/433 (20%), Positives = 168/433 (38%), Gaps = 87/433 (20%)
Query: 84 KLKEVRLDRLHPEG-LGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSI 142
K ++V L + E L S+ GG E G G+F+ + G +A GL+ GD+I+ +NG +
Sbjct: 527 KWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNF 586
Query: 143 SSCTHEEVINLIRTKKTVSIKVR---------------------HIGLIPVKSSPDEPLT 181
+ T + + ++R +++ V+ HI I K S +
Sbjct: 587 ENITFMKAVEILRNNTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSI- 645
Query: 182 WQYV----DQFVSESGGVRGSLGSPGNRENKEKKVF-----------------------I 214
Q+V +Q E G + + NK +K+
Sbjct: 646 -QHVPGDIEQTSQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDD 704
Query: 215 SLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGL-------EIGDQIVEVNGVDFS 267
S+VG+R S++ PI PG +S P L + +I DQ++ V VD
Sbjct: 705 SIVGTRHCRHSLAIMPI--PGT-LSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVD-- 759
Query: 268 NLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMES 327
+++ ++ S + +V A E +T + + + ++ Q+RL +
Sbjct: 760 ----QQSCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQF 815
Query: 328 NKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLP 387
+K+ Q R K E E + +E+ ++ + QL +
Sbjct: 816 SKLADRIQLNGRYYLKN------------NMETETLCSDED------AQELVKESQLSML 857
Query: 388 KTITAEV-HPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPE 446
+ T EV + +R + +EP E DDL + G +++E+ + + +
Sbjct: 858 QLSTIEVATQLSMRDFDLFRNIEP-TEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVAS 916
Query: 447 QIMGKDVRLLRIK 459
+I+ + +L R+K
Sbjct: 917 EILTEANQLKRMK 929
Score = 35.4 bits (80), Expect = 0.14
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 2/73 (2%)
Query: 451 KDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIV 510
+ V L + +E L +L GG + G + V V E G+ G+ +GD+IM +NG+
Sbjct: 529 RQVVLQKASRESPLQFSLNGGSEKGFG-IFVEGV-EPGSKAADSGLKRGDQIMEVNGQNF 586
Query: 511 TDYTLAEAEAALQ 523
+ T +A L+
Sbjct: 587 ENITFMKAVEILR 599
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 58.2 bits (139), Expect = 2e-08
Identities = 44/185 (23%), Positives = 84/185 (45%), Gaps = 19/185 (10%)
Query: 114 ISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR-TKKTVSIKV------- 164
I +I+G AD G L+VGD I+ +NG SI++ +H +++NLI+ TV++++
Sbjct: 1038 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESS 1097
Query: 165 --------RHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISL 216
I I +P + T Q + +P + ++
Sbjct: 1098 NATLLTNAEKIATITTTHTPSQQGT-QETRNTTKPKQESQFEFKAPQATQEQDFYTVELE 1156
Query: 217 VGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAV 275
G++G G S+ G +++ + + G + IGD+I+E+NG N+ H A+
Sbjct: 1157 RGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAI 1216
Query: 276 NVLKS 280
++K+
Sbjct: 1217 ELIKN 1221
Score = 57.4 bits (137), Expect = 3e-08
Identities = 71/317 (22%), Positives = 129/317 (40%), Gaps = 60/317 (18%)
Query: 97 GLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLIR 155
G G + GG E G ++I H++ G AD+ G L+ GDE++ ++G + +H+ V+ L++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
Query: 156 ---TKKTVSIKVRHIGLIPVKSSPDE-----------------------PLTWQYVDQFV 189
+ V++ VR + V + +E P Q V
Sbjct: 910 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTV 969
Query: 190 SESGGVRGSLGSPGN-----------------RENKEKK---VFISLVGSRGLGCSISSG 229
S G +GS G R + + V +S V G + +
Sbjct: 970 SSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGN 1029
Query: 230 PIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLK-SSRSLTIS 287
I + GS + G L++GD+I+ VNG +N H + VN++K + ++T+
Sbjct: 1030 ACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLR 1089
Query: 288 IVAA--AGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEI 345
I+ + +T+ E++A Q+ + R + K QE Q +
Sbjct: 1090 IIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETR---NTTKPKQESQFEFK------ 1140
Query: 346 AQKAAEENERYRKEMEQ 362
A +A +E + Y E+E+
Sbjct: 1141 APQATQEQDFYTVELER 1157
Score = 50.1 bits (118), Expect = 5e-06
Identities = 28/86 (32%), Positives = 46/86 (53%), Gaps = 2/86 (2%)
Query: 71 QVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQ 129
Q E+ + + V L+R +G G S+RGG E+ L++ L + G A+ G ++
Sbjct: 1136 QFEFKAPQATQEQDFYTVELER-GAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMR 1194
Query: 130 VGDEIVRINGYSISSCTHEEVINLIR 155
+GDEI+ ING + + H I LI+
Sbjct: 1195 IGDEILEINGETTKNMKHSRAIELIK 1220
Score = 40.8 bits (94), Expect = 0.003
Identities = 103/494 (20%), Positives = 175/494 (35%), Gaps = 110/494 (22%)
Query: 92 RLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEV 150
R G G +V GG E L I L+ G A G ++ GD IV +N + TH +V
Sbjct: 476 RKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQV 535
Query: 151 INLIRTKKT-VSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGV----RGSLGSPGNR 205
+ + ++ S+ + P+ PD+P T + + + + + SP +
Sbjct: 536 VKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASH 595
Query: 206 ENKEKKV------------FISLVGSRGL---GCSISSGPIQKPGIFISHV--------- 241
+K KV ++ S G S++S +P + H+
Sbjct: 596 SSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGF 655
Query: 242 ----KPGSLSAEV----------GLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTIS 287
PG V GL+ GD IVEVN + L H + V++L
Sbjct: 656 TIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDML--------- 706
Query: 288 IVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQ 347
+ G E+ L+ +R + K + Q +ER+ + +Q
Sbjct: 707 VECPKGSEV--------------------TLLVQRGGLPVPKKSPKSQPLERKDSQNSSQ 746
Query: 348 KAAEENERYR----KEMEQIVEEEEKFKKQWEEDWGSKEQLLL-PKTITAEVHPVPLRKP 402
+ + Q++ E + Q + S Q P I A+ + +P
Sbjct: 747 HSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRP 806
Query: 403 KYDQGVEPELEPADDLDGGTEEQ-------GEQDFRKYEEGFDPYSMFTPEQIMGKDVRL 455
+ P PA L G E+ GE Y+E +D+ L
Sbjct: 807 -----MSP--SPASGLSKGEREREINSTNFGECPIPDYQE---------------QDIFL 844
Query: 456 LRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTL 515
R KE + GG + P + + + GAA+ G + GDE++ ++G V +
Sbjct: 845 WR--KETGFGFRILGG-NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSH 901
Query: 516 AEAEAALQKAWNQG 529
+Q+A QG
Sbjct: 902 QLVVQLMQQAAKQG 915
Score = 36.6 bits (83), Expect = 0.062
Identities = 40/197 (20%), Positives = 77/197 (39%), Gaps = 38/197 (19%)
Query: 327 SNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLL 386
+ K E +E +R+K++ Q+ ++ ++ +++ +Q ++Q E+W L+
Sbjct: 382 NRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQ--------QQQQTEEWTEDHSALV 433
Query: 387 PKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPE 446
P I HP EPA ++ QG+ P+ P
Sbjct: 434 PPVIPN--HP------------PSNPEPAREV----PLQGK-----------PFFTRNPS 464
Query: 447 QIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAIN 506
++ GK + K + GG D P + + ++ G A G + GD I+++N
Sbjct: 465 ELKGKFIHTKLRKSSRGFGFTVVGG-DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVN 523
Query: 507 GKIVTDYTLAEAEAALQ 523
V +T A+ Q
Sbjct: 524 DTCVLGHTHAQVVKIFQ 540
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 58.2 bits (139), Expect = 2e-08
Identities = 58/193 (30%), Positives = 90/193 (46%), Gaps = 25/193 (12%)
Query: 96 EGLGLSVRGG---LEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVI 151
+GLG S+ GG + G+F+ + G A G L+ GDEI+ +NG I T +E I
Sbjct: 595 KGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAI 654
Query: 152 NLIRTKK------TVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESG--------GVRG 197
+ + + TV K+ L P S+P ++ F + G G
Sbjct: 655 HTFKQIRSGLFVLTVRTKLVSPSLTPC-STPTH-MSRSASPNFNTSGGASAGGSDEGSSS 712
Query: 198 SLG--SPGNRENKEKKVFISLVGSRGLGCSISSGPIQK--PGIFISHVKPGSLS-AEVGL 252
SLG +PG ++ +V ++ GLG ++ PGI+I + PGS++ E L
Sbjct: 713 SLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNL 772
Query: 253 EIGDQIVEVNGVD 265
GDQI+EVN V+
Sbjct: 773 SRGDQILEVNSVN 785
Score = 53.5 bits (127), Expect = 5e-07
Identities = 72/324 (22%), Positives = 133/324 (41%), Gaps = 35/324 (10%)
Query: 219 SRGLGCSISSGPIQKPG---IFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEA 274
S GLG +S G K I ++ VK G + G L +GD+++ +NG L H+EA
Sbjct: 341 SDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEA 400
Query: 275 VNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQ 334
V +L+S+ + +VA+ +E AE R + L ++E +
Sbjct: 401 VAILRSATGMVQLVVAS---------KENSAEDLLRLTSKS--LPDLTSSVEDVSSWTDN 449
Query: 335 QEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEV 394
++ E ++ ++ + + Q V E+ K E ++ L ++ V
Sbjct: 450 EDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGV 509
Query: 395 HPVPLRKPKYDQGV---EPE---LEPADD---------LDGGTEEQGEQDFRKYEEGFDP 439
H + + + V +P LE + D LD + Q +K
Sbjct: 510 HRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLST 569
Query: 440 YSMFTPEQIMGKDV-RLLRIKKE--GSLDLALEGGVDSPIGK--VVVSAVYERGAAERHG 494
+ +P +++ V ++ + KE L ++ GG D G+ + V ++ G+A G
Sbjct: 570 TQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDG 629
Query: 495 GIVKGDEIMAINGKIVTDYTLAEA 518
+ +GDEI+ +NG + T EA
Sbjct: 630 RLKEGDEILDVNGIPIKGLTFQEA 653
Score = 52.8 bits (125), Expect = 8e-07
Identities = 48/203 (23%), Positives = 85/203 (41%), Gaps = 17/203 (8%)
Query: 90 LDRLHPEGLGLSVRGGLEFGCGLFISHLI--KGGQADSVGLQVGDEIVRINGYSISSCTH 147
L+R GLG SV GG + H + +G + + GD ++ +NG S++ H
Sbjct: 2625 LNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAH 2684
Query: 148 EEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSP----- 202
V+ ++ ++ L+ +K D+P + + G+ P
Sbjct: 2685 GNVLKVLH-----QAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGI 2739
Query: 203 GNRENKEKKVFISLVG-SRGLGCSISSGPIQKPG---IFISHVKPGSLSAEVGL-EIGDQ 257
G + + ++ S GLG S+ G G + I V G + + G+ E GD+
Sbjct: 2740 GRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDE 2799
Query: 258 IVEVNGVDFSNLDHKEAVNVLKS 280
I+ +NG L H +A N++KS
Sbjct: 2800 ILAINGKPLVGLMHFDAWNIMKS 2822
Score = 46.6 bits (109), Expect = 6e-05
Identities = 26/53 (49%), Positives = 34/53 (64%), Gaps = 2/53 (3%)
Query: 458 IKKEGSLDLALEGGVDSPIGK--VVVSAVYERGAAERHGGIVKGDEIMAINGK 508
+K L L+L+GG S G +V+ VY+ GAAE+ G I GDEI+AINGK
Sbjct: 2754 LKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGK 2806
Score = 45.4 bits (106), Expect = 1e-04
Identities = 42/144 (29%), Positives = 68/144 (47%), Gaps = 21/144 (14%)
Query: 410 PELEPADDLDGGTEEQ---------GEQDFRKYEEG----FDPYSMFTPEQIMGKDVRLL 456
P LE ++ +D GTE + D R++ +G F E++ G+ ++
Sbjct: 279 PHLERSE-VDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEV-GRIWKME 336
Query: 457 RIKKEGSLDLALEGGVDSPIGK--VVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYT 514
+K+ L + + GG S +VV+ V E GAA R G + GDE++ ING ++ +
Sbjct: 337 LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396
Query: 515 LAEAEAALQKAWNQGGDWIDLVVA 538
EA A L+ A + LVVA
Sbjct: 397 HEEAVAILRSATGM----VQLVVA 416
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/79 (36%), Positives = 45/79 (56%), Gaps = 9/79 (11%)
Query: 214 ISLVG-----SRGLGCSISSGPI---QKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGV 264
IS++G +GLG SI+ G + GIF+ + P +AE G L+ GD+I++VNG+
Sbjct: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643
Query: 265 DFSNLDHKEAVNVLKSSRS 283
L +EA++ K RS
Sbjct: 644 PIKGLTFQEAIHTFKQIRS 662
Score = 38.1 bits (87), Expect = 0.021
Identities = 21/65 (32%), Positives = 38/65 (58%), Gaps = 4/65 (6%)
Query: 96 EGLGLSVRGGL---EFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVI 151
+GLG+ V GG + ++ + +GG A G L +GDE++ ING+ + +HEE +
Sbjct: 342 DGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAV 401
Query: 152 NLIRT 156
++R+
Sbjct: 402 AILRS 406
Score = 37.4 bits (85), Expect = 0.036
Identities = 18/50 (36%), Positives = 31/50 (62%), Gaps = 1/50 (2%)
Query: 459 KKEGS-LDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAING 507
+KEGS L ++ GG D + V V+ +GAA + G + +GD ++++NG
Sbjct: 2627 RKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNG 2676
Score = 32.0 bits (71), Expect = 1.5
Identities = 16/71 (22%), Positives = 34/71 (47%)
Query: 459 KKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEA 518
K+ G G +G + V+ + + A + G + DEI+++NG+++ ++ A
Sbjct: 99 KRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGA 158
Query: 519 EAALQKAWNQG 529
++ WN G
Sbjct: 159 SYLAEQCWNGG 169
>gi|9507165 syntrophin, gamma 2 [Homo sapiens]
Length = 539
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/93 (36%), Positives = 53/93 (56%), Gaps = 2/93 (2%)
Query: 81 RSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRING 139
+ R + V L R GLGLS++GG E + IS + + AD G L VGD ++++NG
Sbjct: 67 QGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNG 126
Query: 140 YSISSCTHEEVINLIRTK-KTVSIKVRHIGLIP 171
+ + THEEV++L+R V+I V ++ P
Sbjct: 127 IHVENATHEEVVHLLRNAGDEVTITVEYLREAP 159
Score = 40.0 bits (92), Expect = 0.006
Identities = 20/62 (32%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Query: 221 GLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVLK 279
GLG SI G + IS + + + G L +GD +++VNG+ N H+E V++L+
Sbjct: 83 GLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLR 142
Query: 280 SS 281
++
Sbjct: 143 NA 144
Score = 39.7 bits (91), Expect = 0.007
Identities = 26/90 (28%), Positives = 51/90 (56%), Gaps = 7/90 (7%)
Query: 450 GKDVRLLRIKKE--GSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAING 507
G++ R + ++++ G L L+++GG + + VV+S ++E AA++ G + GD ++ +NG
Sbjct: 68 GRNRRTVTLRRQPVGGLGLSIKGGSEHNV-PVVISKIFEDQAADQTGMLFVGDAVLQVNG 126
Query: 508 KIVTDYTLAEAEAALQKAWNQGGDWIDLVV 537
V + T E L+ A GD + + V
Sbjct: 127 IHVENATHEEVVHLLRNA----GDEVTITV 152
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.136 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,088,742
Number of Sequences: 37866
Number of extensions: 1028084
Number of successful extensions: 13613
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 472
Number of HSP's successfully gapped in prelim test: 559
Number of HSP's that attempted gapping in prelim test: 6072
Number of HSP's gapped (non-prelim): 5043
length of query: 552
length of database: 18,247,518
effective HSP length: 107
effective length of query: 445
effective length of database: 14,195,856
effective search space: 6317155920
effective search space used: 6317155920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.