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Search of human proteins with 62868213
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62868213 golgi associated PDZ and coiled-coil motif
containing isoform b [Homo sapiens]
(454 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62868213 golgi associated PDZ and coiled-coil motif containin... 909 0.0
gi|9966877 golgi associated PDZ and coiled-coil motif containing... 901 0.0
gi|5803177 basic beta 2 syntrophin [Homo sapiens] 85 1e-16
gi|11321640 basic beta 1 syntrophin [Homo sapiens] 83 4e-16
gi|4507137 acidic alpha 1 syntrophin [Homo sapiens] 78 2e-14
gi|9507165 syntrophin, gamma 2 [Homo sapiens] 75 2e-13
gi|8922944 lin-7 homolog C [Homo sapiens] 74 2e-13
gi|4759306 lin-7 homolog A [Homo sapiens] 74 2e-13
gi|11545920 lin-7 homolog B [Homo sapiens] 74 3e-13
gi|9507163 syntrophin, gamma 1 [Homo sapiens] 70 5e-12
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 65 2e-10
gi|112382257 InaD-like [Homo sapiens] 63 6e-10
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 59 9e-09
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 59 9e-09
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 59 9e-09
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 59 1e-08
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 58 2e-08
gi|41281808 harmonin isoform b3 [Homo sapiens] 56 8e-08
gi|71480164 harmonin isoform a [Homo sapiens] 56 8e-08
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 55 1e-07
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 55 1e-07
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 55 1e-07
gi|45827729 scribble isoform b [Homo sapiens] 55 1e-07
gi|45827731 scribble isoform a [Homo sapiens] 55 1e-07
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 55 1e-07
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 55 1e-07
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 55 1e-07
gi|87196343 PDZ domain containing 2 [Homo sapiens] 55 1e-07
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 55 2e-07
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 55 2e-07
>gi|62868213 golgi associated PDZ and coiled-coil motif containing
isoform b [Homo sapiens]
Length = 454
Score = 909 bits (2348), Expect = 0.0
Identities = 454/454 (100%), Positives = 454/454 (100%)
Query: 1 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA 60
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
Sbjct: 1 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA 60
Query: 61 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH 120
DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
Sbjct: 61 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH 120
Query: 121 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEA 180
DQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEA
Sbjct: 121 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEA 180
Query: 181 LRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHR 240
LRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHR
Sbjct: 181 LRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHR 240
Query: 241 HKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKE 300
HKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKE
Sbjct: 241 HKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKE 300
Query: 301 HGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV 360
HGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV
Sbjct: 301 HGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV 360
Query: 361 YVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTD 420
YVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTD
Sbjct: 361 YVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTD 420
Query: 421 THENGDLGTASETPLDDGASKLDDLHTLYHKKSY 454
THENGDLGTASETPLDDGASKLDDLHTLYHKKSY
Sbjct: 421 THENGDLGTASETPLDDGASKLDDLHTLYHKKSY 454
>gi|9966877 golgi associated PDZ and coiled-coil motif containing
isoform a [Homo sapiens]
Length = 462
Score = 901 bits (2329), Expect = 0.0
Identities = 454/462 (98%), Positives = 454/462 (98%), Gaps = 8/462 (1%)
Query: 1 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA 60
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
Sbjct: 1 MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA 60
Query: 61 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH 120
DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
Sbjct: 61 DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH 120
Query: 121 DQLLQLHSIQLQLHAKTGQSADSGTIKAKL--------ERELEANKKEKMKEAQLEAEVK 172
DQLLQLHSIQLQLHAKTGQSADSGTIKAKL ERELEANKKEKMKEAQLEAEVK
Sbjct: 121 DQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK 180
Query: 173 LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL 232
LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL
Sbjct: 181 LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL 240
Query: 233 EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG 292
EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG
Sbjct: 241 EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG 300
Query: 293 ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR 352
ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
Sbjct: 301 ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR 360
Query: 353 GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG 412
GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG
Sbjct: 361 GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG 420
Query: 413 FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY 454
FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
Sbjct: 421 FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY 462
>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
Length = 540
Score = 85.1 bits (209), Expect = 1e-16
Identities = 43/103 (41%), Positives = 66/103 (64%)
Query: 260 APPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRC 319
+PP + ++ P+R+V ++K++ GLGISI GG+E+ +PILIS+I PG AD+
Sbjct: 95 SPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQS 154
Query: 320 GGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYV 362
L +GDAIL+VNG +LR H +AV L + E+ EV ++
Sbjct: 155 RALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFI 197
>gi|11321640 basic beta 1 syntrophin [Homo sapiens]
Length = 538
Score = 83.2 bits (204), Expect = 4e-16
Identities = 45/84 (53%), Positives = 58/84 (69%)
Query: 279 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338
R V +LK++ GLGISI GGKE+ +PILIS+I G AD+ L+VGDAIL+VNG +LRD
Sbjct: 111 RGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRD 170
Query: 339 TKHKEAVTILSQQRGEIEFEVVYV 362
H EAV L + E+ EV Y+
Sbjct: 171 ATHDEAVQALKRAGKEVLLEVKYM 194
>gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
Length = 505
Score = 77.8 bits (190), Expect = 2e-14
Identities = 42/84 (50%), Positives = 55/84 (65%)
Query: 279 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338
R+V + K D GLGISI GG+E+ +PILIS+I G AD+ L VGDAIL+VNG +L
Sbjct: 86 RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145
Query: 339 TKHKEAVTILSQQRGEIEFEVVYV 362
H EAV +L + E+ EV Y+
Sbjct: 146 ATHDEAVQVLKKTGKEVVLEVKYM 169
>gi|9507165 syntrophin, gamma 2 [Homo sapiens]
Length = 539
Score = 74.7 bits (182), Expect = 2e-13
Identities = 37/84 (44%), Positives = 53/84 (63%)
Query: 279 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338
R V L ++ GLG+SI GG EH VP++IS+I Q AD+ G L VGDA+L VNG+++ +
Sbjct: 72 RTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVEN 131
Query: 339 TKHKEAVTILSQQRGEIEFEVVYV 362
H+E V +L E+ V Y+
Sbjct: 132 ATHEEVVHLLRNAGDEVTITVEYL 155
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 74.3 bits (181), Expect = 2e-13
Identities = 39/95 (41%), Positives = 57/95 (60%)
Query: 280 KVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 339
+V+ L + EGLG +I GGKE PI IS I PG ADR GGL GD +L+VNGV++
Sbjct: 92 RVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151
Query: 340 KHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVE 374
H++AV +L +G+++ V Y ++ + E
Sbjct: 152 HHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFE 186
>gi|4759306 lin-7 homolog A [Homo sapiens]
Length = 233
Score = 74.3 bits (181), Expect = 2e-13
Identities = 57/186 (30%), Positives = 91/186 (48%), Gaps = 22/186 (11%)
Query: 202 LDKELAGRVQQIQLLGRDMKGPAH--DKLWNQLEAE-------IHLHRHKTV-IRAC--- 248
LD+++A ++ ++ L + P H L L++E ++ + H+T+ + C
Sbjct: 25 LDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEF 84
Query: 249 RGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILIS 308
R R K + A S+G R V L K D EGLG ++ GGKE PI IS
Sbjct: 85 RARATAKATVAA--------FAASEGHSHPRVVELPKTD-EGLGFNVMGGKEQNSPIYIS 135
Query: 309 EIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDS 368
I PG A+R GGL GD +L+VNGV++ H++AV +L + ++ V Y ++
Sbjct: 136 RIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEE 195
Query: 369 DDENVE 374
+ E
Sbjct: 196 MEARFE 201
>gi|11545920 lin-7 homolog B [Homo sapiens]
Length = 207
Score = 73.9 bits (180), Expect = 3e-13
Identities = 42/90 (46%), Positives = 56/90 (62%), Gaps = 1/90 (1%)
Query: 272 SQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAV 331
S+G R V L K D EGLG +I GGKE PI IS + PG ADR GGL GD +L+V
Sbjct: 85 SEGHAHPRVVELPKTD-EGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSV 143
Query: 332 NGVNLRDTKHKEAVTILSQQRGEIEFEVVY 361
NGV++ +H++AV +L +G ++ V Y
Sbjct: 144 NGVSVEGEQHEKAVELLKAAQGSVKLVVRY 173
>gi|9507163 syntrophin, gamma 1 [Homo sapiens]
Length = 517
Score = 69.7 bits (169), Expect = 5e-12
Identities = 32/84 (38%), Positives = 52/84 (61%)
Query: 279 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338
R V + ++ G G+SI GG EH +P+++S+I Q A+ G L +GDAIL +NG+N+R
Sbjct: 56 RTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRK 115
Query: 339 TKHKEAVTILSQQRGEIEFEVVYV 362
+H+E V +L E+ V ++
Sbjct: 116 CRHEEVVQVLRNAGEEVTLTVSFL 139
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 64.7 bits (156), Expect = 2e-10
Identities = 39/78 (50%), Positives = 47/78 (60%), Gaps = 2/78 (2%)
Query: 272 SQGVGPIRKVLLLK-EDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILA 330
S G G +R V L + + HEGLG SI GG EHGV I +S + PG A++ GL VGD IL
Sbjct: 132 SAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEK-EGLRVGDQILR 190
Query: 331 VNGVNLRDTKHKEAVTIL 348
VN +L H EAV L
Sbjct: 191 VNDKSLARVTHAEAVKAL 208
Score = 58.5 bits (140), Expect = 1e-08
Identities = 37/90 (41%), Positives = 51/90 (56%), Gaps = 2/90 (2%)
Query: 263 GHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGL 322
G + +L QG G +KV L+ D LG++I GG E+G+ I I+ + PG A+ GL
Sbjct: 263 GDRRSTLHLLQG-GDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEG-SGL 320
Query: 323 HVGDAILAVNGVNLRDTKHKEAVTILSQQR 352
VGD IL VNG + + H EAV +L R
Sbjct: 321 KVGDQILEVNGRSFLNILHDEAVRLLKSSR 350
Score = 50.1 bits (118), Expect = 4e-06
Identities = 32/86 (37%), Positives = 45/86 (52%), Gaps = 2/86 (2%)
Query: 267 DSLKKSQGV-GPIRKVLLLKEDHEGLGISITGGKEHGVPI-LISEIHPGQPADRCGGLHV 324
D K G+ P ++ +K+ LGI+I GG P+ I I G A CG L V
Sbjct: 801 DGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKV 860
Query: 325 GDAILAVNGVNLRDTKHKEAVTILSQ 350
G IL VNG+ LR +H+EA I+++
Sbjct: 861 GHVILEVNGLTLRGKEHREAARIIAE 886
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 62.8 bits (151), Expect = 6e-10
Identities = 38/95 (40%), Positives = 57/95 (60%), Gaps = 2/95 (2%)
Query: 281 VLLLKEDHEGLGISITGGKEHGV-PILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 339
++ + + GLG+SI GGK+ + I+I E++ A R G L GD IL VNGV+LR++
Sbjct: 1437 IIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNS 1496
Query: 340 KHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVE 374
H+EA+T L Q ++ VVY D+EN+E
Sbjct: 1497 SHEEAITALRQTPQKVRL-VVYRDEAHYRDEENLE 1530
Score = 55.1 bits (131), Expect = 1e-07
Identities = 52/174 (29%), Positives = 84/174 (48%), Gaps = 23/174 (13%)
Query: 186 AVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVI 245
A++ EVY AA+ D L Q +++ G D++ +H+ EA L + +
Sbjct: 1461 AIVIHEVYEEGAAAR--DGRLWAGDQILEVNGVDLRNSSHE------EAITALRQTPQKV 1512
Query: 246 RACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPI 305
R R++ D+++L+ I V L K+ GLG+SI G K +G +
Sbjct: 1513 RLVVYRDEAHY-------RDEENLE-------IFPVDLQKKAGRGLGLSIVG-KRNGSGV 1557
Query: 306 LISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEV 359
IS+I G AD G L GD IL+VNG ++R+ + TIL +G ++ E+
Sbjct: 1558 FISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI 1611
Score = 50.4 bits (119), Expect = 3e-06
Identities = 32/93 (34%), Positives = 45/93 (48%), Gaps = 9/93 (9%)
Query: 276 GPIRKVLLLKEDHEGLGISITGGK---------EHGVPILISEIHPGQPADRCGGLHVGD 326
GP R V + +E + LGISI GG+ E I I ++ PA + L GD
Sbjct: 1064 GPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
Query: 327 AILAVNGVNLRDTKHKEAVTILSQQRGEIEFEV 359
IL V+GV+L++ H EAV + + F V
Sbjct: 1124 KILEVSGVDLQNASHSEAVEAIKNAGNPVVFIV 1156
Score = 47.4 bits (111), Expect = 3e-05
Identities = 30/85 (35%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Query: 279 RKVLLLKEDHEGLGISITGGKEH---GVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 335
R V + +E + LGISI GG+ +P+ I+ I A R L VGD I+++NG
Sbjct: 1675 RTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQP 1734
Query: 336 LRDTKHKEAVTILSQQRGEIEFEVV 360
L H + V +L G I +VV
Sbjct: 1735 LDGLSHADVVNLLKNAYGRIILQVV 1759
Score = 46.6 bits (109), Expect = 5e-05
Identities = 28/73 (38%), Positives = 39/73 (53%), Gaps = 3/73 (4%)
Query: 276 GPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 335
G + +V L+ D GLG I GGK GV ++ I PG ADR G L GD IL + G N
Sbjct: 244 GHVEEVELIN-DGSGLGFGIVGGKTSGV--VVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
Query: 336 LRDTKHKEAVTIL 348
++ ++ +L
Sbjct: 301 VQGMTSEQVAQVL 313
Score = 43.5 bits (101), Expect = 4e-04
Identities = 22/77 (28%), Positives = 41/77 (53%), Gaps = 1/77 (1%)
Query: 281 VLLLKEDHEGLGISITGGKEHG-VPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 339
++ L++D GLG+S+ G K+ + I + I+P PA G + +GD +L +N L
Sbjct: 1239 IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGR 1298
Query: 340 KHKEAVTILSQQRGEIE 356
H+ A I+ +++
Sbjct: 1299 SHQNASAIIKTAPSKVK 1315
Score = 40.4 bits (93), Expect = 0.003
Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 290 GLGISITGGKEHG---VPILISEIHPGQPADRCGGLHVGDAILAVNGVNL-RDTKHKEAV 345
GLG S+ + V I + ++ PG ADR L D ILA+N L ++ H++A+
Sbjct: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
Query: 346 TILSQQRGEIEFEV 359
+L Q G + V
Sbjct: 204 ALLQQTTGSLRLIV 217
Score = 40.4 bits (93), Expect = 0.003
Identities = 26/73 (35%), Positives = 39/73 (53%), Gaps = 5/73 (6%)
Query: 281 VLLLKEDHEGLGISITG--GKEH---GVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 335
V L+++D + LGI I G G H I + I PG A G + V D I+AV+GVN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 336 LRDTKHKEAVTIL 348
++ + + V +L
Sbjct: 426 IQGFANHDVVEVL 438
Score = 37.0 bits (84), Expect = 0.037
Identities = 28/76 (36%), Positives = 41/76 (53%), Gaps = 4/76 (5%)
Query: 277 PIRKVLLLKEDHEGLGISITGGKEHGVP----ILISEIHPGQPADRCGGLHVGDAILAVN 332
P K++ L +D +GLG SI ++ P I+I + A+R GGL GD +++VN
Sbjct: 682 PEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
Query: 333 GVNLRDTKHKEAVTIL 348
L +T EAV IL
Sbjct: 742 EYCLDNTSLAEAVEIL 757
Score = 33.1 bits (74), Expect = 0.53
Identities = 18/44 (40%), Positives = 23/44 (52%)
Query: 307 ISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQ 350
IS I G P D G L D +L VNG+ L +EAV+ L +
Sbjct: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKE 626
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 58.9 bits (141), Expect = 9e-09
Identities = 48/137 (35%), Positives = 67/137 (48%), Gaps = 18/137 (13%)
Query: 234 AEIHLHRHKTV--IRACRGRNDLKRPMQAPPGH----DQDSLKKSQGVGPIRKVLLLKED 287
A+ H+ + ++ + A + P Q PP + L + RK++L K
Sbjct: 334 ADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGS 393
Query: 288 HEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEA--- 344
GLG +I GG E G I +S I G PAD G L GD IL+VNGVNLR+ H++A
Sbjct: 394 -TGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAA 451
Query: 345 -------VTILSQQRGE 354
VTI++Q R E
Sbjct: 452 LKRAGQSVTIVAQYRPE 468
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/88 (40%), Positives = 50/88 (56%), Gaps = 8/88 (9%)
Query: 278 IRKVLLLKEDHEGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAILAV 331
I +V LLK +GLG SI GG +H +P I I++I G A + G L +GD +LAV
Sbjct: 224 IMEVNLLKGP-KGLGFSIAGGIGNQH-IPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAV 281
Query: 332 NGVNLRDTKHKEAVTILSQQRGEIEFEV 359
N NL+D +H+EAV L + +V
Sbjct: 282 NNTNLQDVRHEEAVASLKNTSDMVYLKV 309
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/74 (37%), Positives = 41/74 (55%), Gaps = 5/74 (6%)
Query: 282 LLLKEDHEGLGISITGGKEH-GVP----ILISEIHPGQPADRCGGLHVGDAILAVNGVNL 336
++L+ + GLG SI GG ++ VP I I++I PG A G L V D +L VN V++
Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
Query: 337 RDTKHKEAVTILSQ 350
+ H AV L +
Sbjct: 192 SEVVHSRAVEALKE 205
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 58.9 bits (141), Expect = 9e-09
Identities = 91/362 (25%), Positives = 145/362 (40%), Gaps = 59/362 (16%)
Query: 39 KEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQL 98
K+ + FVD DL L ++ P+ + + K T + F ++ VS I H L
Sbjct: 619 KDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQ 678
Query: 99 VDLKSELTETQAEKVVLEKEVH---DQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELE 155
L Q K +LE+ +H + L L S+ LQ Q G ++E L
Sbjct: 679 YYL-------QLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLP 731
Query: 156 ANKKEKMKEAQLEAEVKLLRK------ENEALRRHIAVLQAEV-YGARLAAKYLDKE--- 205
A EK+ + ++ E+ L E E + V Q YG + +K+
Sbjct: 732 ARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQT 791
Query: 206 --LAG---------------RVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRH------- 241
L G R ++ R+ K + K L+ +H
Sbjct: 792 GILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNS 851
Query: 242 ---KTVIRACRGRNDLKRPMQAPPGH----DQDSLKKSQGV--GPIRKVLL--LKEDHE- 289
+ ++ C ++ + M+A + D D L K + P R++ L LK+D +
Sbjct: 852 KICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSSPEREITLVNLKKDAKY 911
Query: 290 GLGISITGGKEHG---VPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVT 346
GLG I GG++ G + I IS + PG PAD G L GD +++VN V+L H A+
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 347 IL 348
IL
Sbjct: 972 IL 973
Score = 53.9 bits (128), Expect = 3e-07
Identities = 39/113 (34%), Positives = 55/113 (48%), Gaps = 15/113 (13%)
Query: 276 GPIRKVLLLKEDHEGLGISITGGKEHGVP---ILISEIHPGQPADRCGGLHVGDAILAVN 332
G I +V L K D+ LGIS+TGG V I + + P A+ G +H GD +LAVN
Sbjct: 1173 GDIFEVELAKNDNS-LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVN 1231
Query: 333 GVNLRDTKHKEAV-----------TILSQQRGEIEFEVVYVAPEVDSDDENVE 374
GV+L HK+AV +L + + E V V P+ D+N +
Sbjct: 1232 GVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQ 1284
Score = 42.4 bits (98), Expect = 9e-04
Identities = 28/96 (29%), Positives = 49/96 (51%), Gaps = 12/96 (12%)
Query: 284 LKEDHEGLGISITGGKEHGVP-------ILISEIHPGQPADRCGGLHVGDAILAVNGVNL 336
L ++ GLG S + +++ +P + + ++ PGQPA G + VGD IL VNG +L
Sbjct: 1313 LFKNSSGLGFSFSR-EDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1371
Query: 337 RDTKHKEAVTILSQQRGEIEFEVVY----VAPEVDS 368
+ +E ++ L E+ + V PE+D+
Sbjct: 1372 KGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDT 1407
Score = 32.3 bits (72), Expect = 0.91
Identities = 18/68 (26%), Positives = 35/68 (51%), Gaps = 2/68 (2%)
Query: 281 VLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTK 340
+ L+K + LG ++T G + + + ++ PA G L GD ++ VN ++ +
Sbjct: 1598 ITLIKSEKGSLGFTVTKGNQR-IGCYVHDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMT 1655
Query: 341 HKEAVTIL 348
H +AV +L
Sbjct: 1656 HTDAVNLL 1663
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 58.9 bits (141), Expect = 9e-09
Identities = 40/134 (29%), Positives = 71/134 (52%), Gaps = 13/134 (9%)
Query: 227 KLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKE 286
KL ++ + L H TV A + + + PM ++DS+K ++ L +
Sbjct: 97 KLLSKPNVKALLSVHDTV--AQKNYDPVLPPMPEDIDDEEDSVK----------IIRLVK 144
Query: 287 DHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVT 346
+ E LG +I ++ G I+++ I G ADR G +HVGD + VNG+ + D + +E +
Sbjct: 145 NREPLGATIKKDEQTGA-IIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQ 203
Query: 347 ILSQQRGEIEFEVV 360
IL+Q +G I F+++
Sbjct: 204 ILAQSQGAITFKII 217
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 58.5 bits (140), Expect = 1e-08
Identities = 40/86 (46%), Positives = 50/86 (58%), Gaps = 12/86 (13%)
Query: 279 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338
RK++L K GLG +I GG E G I +S I G PAD G L GD IL+VNGVNLR+
Sbjct: 48 RKIILHKGS-TGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 105
Query: 339 TKHKEA----------VTILSQQRGE 354
H++A VTI++Q R E
Sbjct: 106 ATHEQAAAALKRAGQSVTIVAQYRPE 131
>gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
Length = 1076
Score = 57.8 bits (138), Expect = 2e-08
Identities = 62/241 (25%), Positives = 111/241 (46%), Gaps = 18/241 (7%)
Query: 118 EVHDQLLQLHSIQLQ--LHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLR 175
++ D+++ ++ I + + Q +I +K+ E+E + E + + VKL +
Sbjct: 467 QIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPK 526
Query: 176 KENEALRRHIAVLQAEVYGARLAAKYLDK-ELAGRVQQIQLLGRDMKGPAHDKLWN-QLE 233
K N L I+ + G L + K +A R ++L G + + +L N +E
Sbjct: 527 KHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLEL-GDKLLAIDNIRLDNCSME 585
Query: 234 AEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGI 293
+ +++ C LK D+D+ + + G I + LK LGI
Sbjct: 586 DAVQ------ILQQCEDLVKLKIRK------DEDNSDEQESSGAIIYTVELKRYGGPLGI 633
Query: 294 SITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRG 353
+I+G +E PI+IS + G A+R G +H+GD ILA+N +L+ EA+ +L Q G
Sbjct: 634 TISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLL-QMAG 692
Query: 354 E 354
E
Sbjct: 693 E 693
Score = 53.9 bits (128), Expect = 3e-07
Identities = 31/93 (33%), Positives = 48/93 (51%)
Query: 281 VLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTK 340
V L+K++ LG++++GG + +S + G A R L VGD I AVNG+NL +
Sbjct: 54 VELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFR 113
Query: 341 HKEAVTILSQQRGEIEFEVVYVAPEVDSDDENV 373
H E +++L + EV Y P V +V
Sbjct: 114 HDEIISLLKNVGERVVLEVEYELPPVSVQGSSV 146
Score = 52.8 bits (125), Expect = 7e-07
Identities = 31/89 (34%), Positives = 47/89 (52%), Gaps = 4/89 (4%)
Query: 284 LKEDHEGLGISITGG----KEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 339
L ++ G I GG + P++I+ + PG PADR G + GD +L+V+G+ L T
Sbjct: 155 LHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGT 214
Query: 340 KHKEAVTILSQQRGEIEFEVVYVAPEVDS 368
H EA++IL Q E + Y +DS
Sbjct: 215 THAEAMSILKQCGQEAALLIEYDVSVMDS 243
Score = 52.0 bits (123), Expect = 1e-06
Identities = 36/118 (30%), Positives = 64/118 (54%), Gaps = 11/118 (9%)
Query: 281 VLLLKEDHEGLGISITG--GKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338
V L K+ + LGI+I+ ++ G P++IS+I G A R G L +GD +LA++ + L +
Sbjct: 522 VKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDN 581
Query: 339 TKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNP 396
++AV IL Q ++ ++ D++N + ++ SG +Y EL+ G P
Sbjct: 582 CSMEDAVQILQQCEDLVKL-------KIRKDEDNSDEQESSG--AIIYTVELKRYGGP 630
Score = 51.2 bits (121), Expect = 2e-06
Identities = 32/90 (35%), Positives = 48/90 (53%), Gaps = 10/90 (11%)
Query: 280 KVLLLKEDHEGLGISITGG----KEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 335
+V+L + G GI + G + P LIS I PA+RCG L +GD ++A+NG+
Sbjct: 420 EVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIP 479
Query: 336 LRDTKHKEAVTIL------SQQRGEIEFEV 359
D+ +EA +L S+ EIEF+V
Sbjct: 480 TEDSTFEEASQLLRDSSITSKVTLEIEFDV 509
Score = 44.3 bits (103), Expect = 2e-04
Identities = 20/56 (35%), Positives = 33/56 (58%)
Query: 305 ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV 360
I+I +I ADRCG LHVGD IL+++G ++ EA L+ +++ E++
Sbjct: 278 IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL 333
>gi|41281808 harmonin isoform b3 [Homo sapiens]
Length = 899
Score = 55.8 bits (133), Expect = 8e-08
Identities = 41/145 (28%), Positives = 76/145 (52%), Gaps = 16/145 (11%)
Query: 257 PMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPA 316
P++ +DQ + ++S+ +++V L + EGLG+S+ GG E G + IS + G A
Sbjct: 67 PLKHQVEYDQLTPRRSR---KLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQA 123
Query: 317 DRCGGLHVGDAILAVNGVNLRDTKHKEAVTIL-SQQRGEIEFEVVYVAPEVDSDDENVEY 375
D GL VGD I+ +NG ++ H+E + ++ +++ I+ + + P S DE + +
Sbjct: 124 DSV-GLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTW 182
Query: 376 EDESGHRYRLYLDEL--EGGGNPGA 398
+ Y+D+ E GG G+
Sbjct: 183 Q---------YVDQFVSESGGVRGS 198
Score = 50.8 bits (120), Expect = 2e-06
Identities = 29/74 (39%), Positives = 39/74 (52%), Gaps = 1/74 (1%)
Query: 279 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338
+KV + GLG SI+ G I IS + PG + G L +GD I+ VNGV+ +
Sbjct: 210 KKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSN 268
Query: 339 TKHKEAVTILSQQR 352
HKEAV +L R
Sbjct: 269 LDHKEAVNVLKSSR 282
Score = 43.5 bits (101), Expect = 4e-04
Identities = 40/133 (30%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 254 LKRPMQAPPGHDQDSLKKSQGVGPI----------RKVLLLKEDHEG-LGISITGGKEHG 302
LKR + QD K +G P + V LL+ EG L +++ GG +
Sbjct: 716 LKRMVVYQTAFRQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSP 775
Query: 303 V-PILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQ---QRGEIEFE 358
+ +++S ++ A+R GG+ GD I+A+NG + D EA L + Q G+
Sbjct: 776 IGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDL 835
Query: 359 VVYVAPEVDSDDE 371
VV V P + DDE
Sbjct: 836 VVAVCPPKEYDDE 848
>gi|71480164 harmonin isoform a [Homo sapiens]
Length = 552
Score = 55.8 bits (133), Expect = 8e-08
Identities = 41/145 (28%), Positives = 76/145 (52%), Gaps = 16/145 (11%)
Query: 257 PMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPA 316
P++ +DQ + ++S+ +++V L + EGLG+S+ GG E G + IS + G A
Sbjct: 67 PLKHQVEYDQLTPRRSR---KLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQA 123
Query: 317 DRCGGLHVGDAILAVNGVNLRDTKHKEAVTIL-SQQRGEIEFEVVYVAPEVDSDDENVEY 375
D GL VGD I+ +NG ++ H+E + ++ +++ I+ + + P S DE + +
Sbjct: 124 DSV-GLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTW 182
Query: 376 EDESGHRYRLYLDEL--EGGGNPGA 398
+ Y+D+ E GG G+
Sbjct: 183 Q---------YVDQFVSESGGVRGS 198
Score = 50.8 bits (120), Expect = 2e-06
Identities = 29/74 (39%), Positives = 39/74 (52%), Gaps = 1/74 (1%)
Query: 279 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338
+KV + GLG SI+ G I IS + PG + G L +GD I+ VNGV+ +
Sbjct: 210 KKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSN 268
Query: 339 TKHKEAVTILSQQR 352
HKEAV +L R
Sbjct: 269 LDHKEAVNVLKSSR 282
Score = 43.9 bits (102), Expect = 3e-04
Identities = 74/301 (24%), Positives = 124/301 (41%), Gaps = 52/301 (17%)
Query: 118 EVHDQLLQLHSIQLQ-LHAKTG----QSADSGTIK--AKLERELEANKKEKMKEA---QL 167
E+ DQ+++++ + L K +S+ S TI A REL +E++ EA +L
Sbjct: 253 EIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQREL 312
Query: 168 EAEVKLLRKENEALRRHIAVLQAEVYGAR---LAAKYLDKELAGRVQQIQLLGRDMKGPA 224
+ + L++K I Q E+ R +A K ++ R + Q++ + K
Sbjct: 313 QRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEK--- 369
Query: 225 HDKLWNQ---------LEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGV 275
K W + L I H +R + + D + P D D + QG
Sbjct: 370 FKKQWEEDWGSKEQLLLPKTITAEVHPVPLR--KPKYDQGVEPELEPADDLDGGTEEQGE 427
Query: 276 GPIRK--------------------VLLLKEDHEG-LGISITGGKEHGV-PILISEIHPG 313
RK V LL+ EG L +++ GG + + +++S ++
Sbjct: 428 QDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYER 487
Query: 314 QPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQ---QRGEIEFEVVYVAPEVDSDD 370
A+R GG+ GD I+A+NG + D EA L + Q G+ VV V P + DD
Sbjct: 488 GAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDD 547
Query: 371 E 371
E
Sbjct: 548 E 548
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 55.5 bits (132), Expect = 1e-07
Identities = 35/73 (47%), Positives = 43/73 (58%), Gaps = 2/73 (2%)
Query: 276 GPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 335
G RKV+L K GLG +I GG E G I +S I G PAD G L GD IL+VNG++
Sbjct: 314 GEPRKVVLHKGS-TGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 371
Query: 336 LRDTKHKEAVTIL 348
LR H++A L
Sbjct: 372 LRGASHEQAAAAL 384
Score = 45.8 bits (107), Expect = 8e-05
Identities = 32/80 (40%), Positives = 44/80 (55%), Gaps = 12/80 (15%)
Query: 289 EGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHK 342
+GLG SI GG +H +P I +++I G A + G L VGD +L VN +L + H+
Sbjct: 150 KGLGFSIAGGVGNQH-IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 208
Query: 343 EAVTILSQQRGEIEFEVVYV 362
EAV IL EVVY+
Sbjct: 209 EAVAILKNTS-----EVVYL 223
Score = 44.7 bits (104), Expect = 2e-04
Identities = 27/74 (36%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 282 LLLKEDHEGLGISITGGKEH-----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNL 336
+ L+ + GLG SI GG ++ I I++I PG A G L V D IL VN V++
Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
Query: 337 RDTKHKEAVTILSQ 350
+ H +AV L +
Sbjct: 108 SEVSHSKAVEALKE 121
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 55.5 bits (132), Expect = 1e-07
Identities = 35/73 (47%), Positives = 43/73 (58%), Gaps = 2/73 (2%)
Query: 276 GPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 335
G RKV+L K GLG +I GG E G I +S I G PAD G L GD IL+VNG++
Sbjct: 522 GEPRKVVLHKGS-TGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 579
Query: 336 LRDTKHKEAVTIL 348
LR H++A L
Sbjct: 580 LRGASHEQAAAAL 592
Score = 45.8 bits (107), Expect = 8e-05
Identities = 32/80 (40%), Positives = 44/80 (55%), Gaps = 12/80 (15%)
Query: 289 EGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHK 342
+GLG SI GG +H +P I +++I G A + G L VGD +L VN +L + H+
Sbjct: 306 KGLGFSIAGGVGNQH-IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 364
Query: 343 EAVTILSQQRGEIEFEVVYV 362
EAV IL EVVY+
Sbjct: 365 EAVAILKNTS-----EVVYL 379
Score = 44.7 bits (104), Expect = 2e-04
Identities = 27/74 (36%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 282 LLLKEDHEGLGISITGGKEH-----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNL 336
+ L+ + GLG SI GG ++ I I++I PG A G L V D IL VN V++
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
Query: 337 RDTKHKEAVTILSQ 350
+ H +AV L +
Sbjct: 264 SEVSHSKAVEALKE 277
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 55.5 bits (132), Expect = 1e-07
Identities = 35/73 (47%), Positives = 43/73 (58%), Gaps = 2/73 (2%)
Query: 276 GPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVN 335
G RKV+L K GLG +I GG E G I +S I G PAD G L GD IL+VNG++
Sbjct: 417 GEPRKVVLHKGS-TGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 474
Query: 336 LRDTKHKEAVTIL 348
LR H++A L
Sbjct: 475 LRGASHEQAAAAL 487
Score = 45.8 bits (107), Expect = 8e-05
Identities = 32/80 (40%), Positives = 44/80 (55%), Gaps = 12/80 (15%)
Query: 289 EGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHK 342
+GLG SI GG +H +P I +++I G A + G L VGD +L VN +L + H+
Sbjct: 201 KGLGFSIAGGVGNQH-IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 259
Query: 343 EAVTILSQQRGEIEFEVVYV 362
EAV IL EVVY+
Sbjct: 260 EAVAILKNTS-----EVVYL 274
Score = 44.7 bits (104), Expect = 2e-04
Identities = 27/74 (36%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 282 LLLKEDHEGLGISITGGKEH-----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNL 336
+ L+ + GLG SI GG ++ I I++I PG A G L V D IL VN V++
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 337 RDTKHKEAVTILSQ 350
+ H +AV L +
Sbjct: 159 SEVSHSKAVEALKE 172
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 55.5 bits (132), Expect = 1e-07
Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 8/82 (9%)
Query: 276 GPIRK--VLLLKEDHEGLGISITGGKEH------GVPILISEIHPGQPADRCGGLHVGDA 327
GP+R+ V L GLG SI GGK I +S I G A R G L VGD
Sbjct: 855 GPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDR 914
Query: 328 ILAVNGVNLRDTKHKEAVTILS 349
+L++NGV++ + +H AV++L+
Sbjct: 915 VLSINGVDVTEARHDHAVSLLT 936
Score = 50.1 bits (118), Expect = 4e-06
Identities = 35/84 (41%), Positives = 49/84 (58%), Gaps = 10/84 (11%)
Query: 273 QGVGPIRKVLLLKEDHEGLGISITGGKEH-----GVP---ILISEIHPGQPADRCGGLHV 324
+G P+ ++ L + LG+SI GG +H GV + IS++ P A R GL V
Sbjct: 997 EGPYPVEEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLRV 1054
Query: 325 GDAILAVNGVNLRDTKHKEAVTIL 348
GD ILAVNG ++RD H+EAV+ L
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSAL 1078
Score = 44.7 bits (104), Expect = 2e-04
Identities = 31/67 (46%), Positives = 37/67 (55%), Gaps = 11/67 (16%)
Query: 290 GLGISITGGK--------EHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 341
GLGISI GGK + G I IS + PA R G + VGD +L VNGV L+ +H
Sbjct: 737 GLGISIAGGKGSTPYKGDDEG--IFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793
Query: 342 KEAVTIL 348
EAV L
Sbjct: 794 HEAVEAL 800
Score = 43.1 bits (100), Expect = 5e-04
Identities = 40/121 (33%), Positives = 52/121 (42%), Gaps = 23/121 (19%)
Query: 237 HLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISIT 296
H ++R C + L R APPG +R++ + K E LGISI
Sbjct: 1071 HQEAVSALLRPCLELSLLVRRDPAPPG--------------LRELCIQKAPGERLGISIR 1116
Query: 297 GGK--EHGVP-------ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTI 347
GG G P I IS++ P A R G L VG +L VN +L H EAV +
Sbjct: 1117 GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQL 1176
Query: 348 L 348
L
Sbjct: 1177 L 1177
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 55.5 bits (132), Expect = 1e-07
Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 8/82 (9%)
Query: 276 GPIRK--VLLLKEDHEGLGISITGGKEH------GVPILISEIHPGQPADRCGGLHVGDA 327
GP+R+ V L GLG SI GGK I +S I G A R G L VGD
Sbjct: 855 GPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDR 914
Query: 328 ILAVNGVNLRDTKHKEAVTILS 349
+L++NGV++ + +H AV++L+
Sbjct: 915 VLSINGVDVTEARHDHAVSLLT 936
Score = 50.1 bits (118), Expect = 4e-06
Identities = 35/84 (41%), Positives = 49/84 (58%), Gaps = 10/84 (11%)
Query: 273 QGVGPIRKVLLLKEDHEGLGISITGGKEH-----GVP---ILISEIHPGQPADRCGGLHV 324
+G P+ ++ L + LG+SI GG +H GV + IS++ P A R GL V
Sbjct: 997 EGPYPVEEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLRV 1054
Query: 325 GDAILAVNGVNLRDTKHKEAVTIL 348
GD ILAVNG ++RD H+EAV+ L
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSAL 1078
Score = 44.7 bits (104), Expect = 2e-04
Identities = 31/67 (46%), Positives = 37/67 (55%), Gaps = 11/67 (16%)
Query: 290 GLGISITGGK--------EHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 341
GLGISI GGK + G I IS + PA R G + VGD +L VNGV L+ +H
Sbjct: 737 GLGISIAGGKGSTPYKGDDEG--IFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793
Query: 342 KEAVTIL 348
EAV L
Sbjct: 794 HEAVEAL 800
Score = 43.1 bits (100), Expect = 5e-04
Identities = 40/121 (33%), Positives = 52/121 (42%), Gaps = 23/121 (19%)
Query: 237 HLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISIT 296
H ++R C + L R APPG +R++ + K E LGISI
Sbjct: 1071 HQEAVSALLRPCLELSLLVRRDPAPPG--------------LRELCIQKAPGERLGISIR 1116
Query: 297 GGK--EHGVP-------ILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTI 347
GG G P I IS++ P A R G L VG +L VN +L H EAV +
Sbjct: 1117 GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQL 1176
Query: 348 L 348
L
Sbjct: 1177 L 1177
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 55.1 bits (131), Expect = 1e-07
Identities = 35/83 (42%), Positives = 47/83 (56%), Gaps = 11/83 (13%)
Query: 282 LLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 341
+++ GLG +I GG E G I IS I G PAD G L GD IL+VNGV+LR+ H
Sbjct: 357 IVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASH 415
Query: 342 KEA----------VTILSQQRGE 354
++A VTI++Q + E
Sbjct: 416 EQAAIALKNAGQTVTIIAQYKPE 438
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/94 (38%), Positives = 52/94 (55%), Gaps = 14/94 (14%)
Query: 277 PIRKVLLLK--EDHEGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAI 328
P KV+ +K + +GLG SI GG +H +P I +++I G A + G L +GD I
Sbjct: 197 PAEKVMEIKLIKGPKGLGFSIAGGVGNQH-IPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 255
Query: 329 LAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYV 362
LAVN V L D H++AV L ++VVY+
Sbjct: 256 LAVNSVGLEDVMHEDAVAALKN-----TYDVVYL 284
Score = 47.4 bits (111), Expect = 3e-05
Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 282 LLLKEDHEGLGISITGGKEH-----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNL 336
+ L+ + GLG SI GG ++ I I++I PG A + G L V D+IL VN V++
Sbjct: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
Query: 337 RDTKHKEAVTILSQQRGEIEFEVVYVAPEVD 367
R+ H AV L + + V+ P +
Sbjct: 169 REVTHSAAVEALKEAGSIVRLYVMRRKPPAE 199
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 55.1 bits (131), Expect = 1e-07
Identities = 35/83 (42%), Positives = 47/83 (56%), Gaps = 11/83 (13%)
Query: 282 LLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 341
+++ GLG +I GG E G I IS I G PAD G L GD IL+VNGV+LR+ H
Sbjct: 311 IVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASH 369
Query: 342 KEA----------VTILSQQRGE 354
++A VTI++Q + E
Sbjct: 370 EQAAIALKNAGQTVTIIAQYKPE 392
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/94 (38%), Positives = 52/94 (55%), Gaps = 14/94 (14%)
Query: 277 PIRKVLLLK--EDHEGLGISITGG--KEHGVP----ILISEIHPGQPADRCGGLHVGDAI 328
P KV+ +K + +GLG SI GG +H +P I +++I G A + G L +GD I
Sbjct: 151 PAEKVMEIKLIKGPKGLGFSIAGGVGNQH-IPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 209
Query: 329 LAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYV 362
LAVN V L D H++AV L ++VVY+
Sbjct: 210 LAVNSVGLEDVMHEDAVAALKN-----TYDVVYL 238
Score = 47.4 bits (111), Expect = 3e-05
Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 282 LLLKEDHEGLGISITGGKEH-----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNL 336
+ L+ + GLG SI GG ++ I I++I PG A + G L V D+IL VN V++
Sbjct: 63 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122
Query: 337 RDTKHKEAVTILSQQRGEIEFEVVYVAPEVD 367
R+ H AV L + + V+ P +
Sbjct: 123 REVTHSAAVEALKEAGSIVRLYVMRRKPPAE 153
>gi|122937249 glutamate receptor interacting protein 2 [Homo
sapiens]
Length = 1141
Score = 55.1 bits (131), Expect = 1e-07
Identities = 30/87 (34%), Positives = 48/87 (55%)
Query: 278 IRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLR 337
I V L+K++ LG++I+GG + +S + PG A R L++GD I +VNG++L
Sbjct: 143 ITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLT 202
Query: 338 DTKHKEAVTILSQQRGEIEFEVVYVAP 364
+H E +T+L + EV Y P
Sbjct: 203 RLRHDEIITLLKNVGERVVLEVEYELP 229
Score = 54.7 bits (130), Expect = 2e-07
Identities = 34/90 (37%), Positives = 52/90 (57%), Gaps = 1/90 (1%)
Query: 265 DQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHV 324
D+D+ + + G + + LK LGI+I+G +E PI+IS + A+R G +HV
Sbjct: 738 DEDNSDELETTGAVSYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHV 797
Query: 325 GDAILAVNGVNLRDTKHKEAVTILSQQRGE 354
GD ILA+N V+L+ EA+ +L Q GE
Sbjct: 798 GDRILAINNVSLKGRPLSEAIHLL-QVAGE 826
Score = 50.8 bits (120), Expect = 2e-06
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 284 LKEDHEGLGISITGGKEH----GVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 339
L ++ G + GG P++++ + PG PADR G L VGD +L+V+G+ L
Sbjct: 248 LYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGA 307
Query: 340 KHKEAVTILSQQRGEIEFEVVY 361
H A+ L Q E F+V Y
Sbjct: 308 SHATALATLRQCSHEALFQVEY 329
Score = 49.3 bits (116), Expect = 7e-06
Identities = 38/127 (29%), Positives = 55/127 (43%), Gaps = 18/127 (14%)
Query: 251 RNDLKRPMQAPPGHDQDSLKKSQGVGP--------IRKVLLLKEDHEGLGISITGG---- 298
R + R Q H S VGP +V+L + G G+ + GG
Sbjct: 517 RTTMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFAT 576
Query: 299 KEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR------ 352
+ P L+ I P PA+RCG L VGD +L++NG+ D +EA +L
Sbjct: 577 ETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVV 636
Query: 353 GEIEFEV 359
E+EF+V
Sbjct: 637 LEVEFDV 643
Score = 47.0 bits (110), Expect = 4e-05
Identities = 39/143 (27%), Positives = 66/143 (46%), Gaps = 11/143 (7%)
Query: 281 VLLLKEDHEGLGISITGG-KEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 339
V L K+ LGI+I+ ++ G P++IS+I G A R G L GD +LA++ + L +
Sbjct: 656 VKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNC 715
Query: 340 KHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGAS 399
++AV IL Q ++ ++ +D + E E Y + L GG G +
Sbjct: 716 PMEDAVQILRQCEDLVKLKI------RKDEDNSDELETTGAVSYTVELKRY--GGPLGIT 767
Query: 400 CKDTSGEIK--VLQGFNKKAVTD 420
T V+ G K+ + +
Sbjct: 768 ISGTEEPFDPIVISGLTKRGLAE 790
Score = 43.5 bits (101), Expect = 4e-04
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 2/88 (2%)
Query: 276 GPIRKVLLLKEDHEGLGISITGGKEHGVPIL-ISEIHPGQPADRCGGLHVGDAILAVNGV 334
GP+ V ++K LGIS+T ++ I I P DR G LH GD IL+++G
Sbjct: 342 GPLM-VEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGT 400
Query: 335 NLRDTKHKEAVTILSQQRGEIEFEVVYV 362
++ EA +L+ ++ E++ V
Sbjct: 401 SMEHCSLLEATKLLASISEKVRLEILPV 428
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 55.1 bits (131), Expect = 1e-07
Identities = 35/88 (39%), Positives = 50/88 (56%), Gaps = 4/88 (4%)
Query: 275 VGPIRKVLLLKEDHEGLGISITGG---KEHGVPILISEIHPGQPADRCGGLHVGDAILAV 331
VG I K+ LLKE +GLGI ++GG K I+++++ G A R G L +GD +L +
Sbjct: 329 VGRIWKMELLKES-DGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVI 387
Query: 332 NGVNLRDTKHKEAVTILSQQRGEIEFEV 359
NG L H+EAV IL G ++ V
Sbjct: 388 NGHLLVGLSHEEAVAILRSATGMVQLVV 415
Score = 43.9 bits (102), Expect = 3e-04
Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 19/148 (12%)
Query: 217 GRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPM--QAPPGHDQDSLKKSQ- 273
G + G AH N L+ HK + + D RP Q PP + L +
Sbjct: 2676 GASLAGLAHG---NVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKT 2732
Query: 274 -----GVG---PIRKVLLLK--EDHEGLGISITGGKEHGV---PILISEIHPGQPADRCG 320
G+G + L ++ + GLG+S+ GGK P++I ++ G A++ G
Sbjct: 2733 IPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAG 2792
Query: 321 GLHVGDAILAVNGVNLRDTKHKEAVTIL 348
+ GD ILA+NG L H +A I+
Sbjct: 2793 IIEAGDEILAINGKPLVGLMHFDAWNIM 2820
Score = 43.1 bits (100), Expect = 5e-04
Identities = 27/73 (36%), Positives = 37/73 (50%), Gaps = 3/73 (4%)
Query: 283 LLKEDHEGLGISITGGKE---HGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 339
L KE +GLG SI GG++ + I + I P A G L GD IL VNG+ ++
Sbjct: 589 LYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648
Query: 340 KHKEAVTILSQQR 352
+EA+ Q R
Sbjct: 649 TFQEAIHTFKQIR 661
Score = 38.5 bits (88), Expect = 0.013
Identities = 22/86 (25%), Positives = 44/86 (51%), Gaps = 1/86 (1%)
Query: 266 QDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKE-HGVPILISEIHPGQPADRCGGLHV 324
Q++ +S+ + ++L +++ GLG S+ GG + I + + A + G ++
Sbjct: 2608 QEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNR 2667
Query: 325 GDAILAVNGVNLRDTKHKEAVTILSQ 350
GD +L+VNG +L H + +L Q
Sbjct: 2668 GDFLLSVNGASLAGLAHGNVLKVLHQ 2693
Score = 35.0 bits (79), Expect = 0.14
Identities = 28/75 (37%), Positives = 35/75 (46%), Gaps = 2/75 (2%)
Query: 278 IRKVLLLKEDHEGLGISITG-GKEHGVP-ILISEIHPGQPADRCGGLHVGDAILAVNGVN 335
+ +V L KE GLGI E+ P I I + PG A L GD IL VN VN
Sbjct: 726 VMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVN 785
Query: 336 LRDTKHKEAVTILSQ 350
+R + ILS+
Sbjct: 786 VRHAALSKVHAILSK 800
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 54.7 bits (130), Expect = 2e-07
Identities = 21/65 (32%), Positives = 39/65 (60%)
Query: 284 LKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKE 343
L+ +G G S+ GG+E+ + + + + PA+RCG + +GD IL +NG ++ KH
Sbjct: 1155 LERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSR 1214
Query: 344 AVTIL 348
A+ ++
Sbjct: 1215 AIELI 1219
Score = 51.6 bits (122), Expect = 1e-06
Identities = 24/69 (34%), Positives = 36/69 (52%)
Query: 292 GISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQ 351
G + G +P I I G PADRCG L VGD ILAVNG ++ + H + V ++ +
Sbjct: 1023 GTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEA 1082
Query: 352 RGEIEFEVV 360
+ ++
Sbjct: 1083 GNTVTLRII 1091
Score = 45.8 bits (107), Expect = 8e-05
Identities = 28/94 (29%), Positives = 45/94 (47%), Gaps = 6/94 (6%)
Query: 282 LLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 341
+ L G G I GG E G PI I I P AD G L GD ++ V+G + H
Sbjct: 842 IFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSH 901
Query: 342 KEAVTILSQ--QRGEIEF----EVVYVAPEVDSD 369
+ V ++ Q ++G + +VV+ P+ +++
Sbjct: 902 QLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENE 935
Score = 32.0 bits (71), Expect = 1.2
Identities = 21/105 (20%), Positives = 44/105 (41%), Gaps = 5/105 (4%)
Query: 270 KKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGG-----LHV 324
KK+ + + + + LG+++ GG EHG + + + A GG L
Sbjct: 7 KKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGE 66
Query: 325 GDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSD 369
G+ +L V GV + + + ++ + + F+ V ++ D
Sbjct: 67 GELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKD 111
Score = 32.0 bits (71), Expect = 1.2
Identities = 18/64 (28%), Positives = 29/64 (45%)
Query: 284 LKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKE 343
L++ G G ++ GG E + I + PA G + GD I++VN + H +
Sbjct: 475 LRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
Query: 344 AVTI 347
V I
Sbjct: 535 VVKI 538
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 54.7 bits (130), Expect = 2e-07
Identities = 21/65 (32%), Positives = 39/65 (60%)
Query: 284 LKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKE 343
L+ +G G S+ GG+E+ + + + + PA+RCG + +GD IL +NG ++ KH
Sbjct: 1126 LERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSR 1185
Query: 344 AVTIL 348
A+ ++
Sbjct: 1186 AIELI 1190
Score = 50.1 bits (118), Expect = 4e-06
Identities = 22/58 (37%), Positives = 33/58 (56%)
Query: 303 VPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV 360
+P I I G PADRCG L VGD ILAVNG ++ + H + V ++ + + ++
Sbjct: 1005 MPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1062
Score = 45.8 bits (107), Expect = 8e-05
Identities = 28/94 (29%), Positives = 45/94 (47%), Gaps = 6/94 (6%)
Query: 282 LLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKH 341
+ L G G I GG E G PI I I P AD G L GD ++ V+G + H
Sbjct: 814 IFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSH 873
Query: 342 KEAVTILSQ--QRGEIEF----EVVYVAPEVDSD 369
+ V ++ Q ++G + +VV+ P+ +++
Sbjct: 874 QLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENE 907
Score = 32.0 bits (71), Expect = 1.2
Identities = 21/105 (20%), Positives = 44/105 (41%), Gaps = 5/105 (4%)
Query: 270 KKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGG-----LHV 324
KK+ + + + + LG+++ GG EHG + + + A GG L
Sbjct: 7 KKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGE 66
Query: 325 GDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSD 369
G+ +L V GV + + + ++ + + F+ V ++ D
Sbjct: 67 GELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKD 111
Score = 32.0 bits (71), Expect = 1.2
Identities = 18/64 (28%), Positives = 29/64 (45%)
Query: 284 LKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKE 343
L++ G G ++ GG E + I + PA G + GD I++VN + H +
Sbjct: 475 LRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
Query: 344 AVTI 347
V I
Sbjct: 535 VVKI 538
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.133 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,629,350
Number of Sequences: 37866
Number of extensions: 898364
Number of successful extensions: 5588
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 396
Number of HSP's that attempted gapping in prelim test: 4339
Number of HSP's gapped (non-prelim): 1497
length of query: 454
length of database: 18,247,518
effective HSP length: 106
effective length of query: 348
effective length of database: 14,233,722
effective search space: 4953335256
effective search space used: 4953335256
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.