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Search of human proteins with 6005942
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6005942 valosin-containing protein [Homo sapiens]
(806 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6005942 valosin-containing protein [Homo sapiens] 1599 0.0
gi|157671927 spermatogenesis associated 5 [Homo sapiens] 539 e-153
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens] 474 e-133
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens] 474 e-133
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens] 425 e-119
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens] 297 3e-80
gi|4505725 peroxin1 [Homo sapiens] 273 4e-73
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens] 223 4e-58
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens] 220 5e-57
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens] 215 1e-55
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens] 208 2e-53
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens] 202 1e-51
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens] 202 1e-51
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens] 199 1e-50
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens] 196 7e-50
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ... 195 1e-49
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi... 195 1e-49
gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens] 195 1e-49
gi|156564401 vesicle-fusing ATPase [Homo sapiens] 189 9e-48
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens] 189 1e-47
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens] 189 1e-47
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens] 189 1e-47
gi|5901990 katanin p60 subunit A 1 [Homo sapiens] 187 3e-47
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens] 178 2e-44
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens] 178 2e-44
gi|31742536 fidgetin-like 1 [Homo sapiens] 169 7e-42
gi|112789543 fidgetin-like 1 [Homo sapiens] 169 7e-42
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens] 164 3e-40
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens] 161 2e-39
gi|113426932 PREDICTED: similar to N-ethylmaleimide-sensitive fa... 161 3e-39
>gi|6005942 valosin-containing protein [Homo sapiens]
Length = 806
Score = 1599 bits (4140), Expect = 0.0
Identities = 806/806 (100%), Positives = 806/806 (100%)
Query: 1 MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK 60
MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK
Sbjct: 1 MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK 60
Query: 61 GKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPID 120
GKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPID
Sbjct: 61 GKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPID 120
Query: 121 DTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDT 180
DTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDT
Sbjct: 121 DTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDT 180
Query: 181 VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRG 240
VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRG
Sbjct: 181 VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRG 240
Query: 241 ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI 300
ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI
Sbjct: 241 ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI 300
Query: 301 IFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF 360
IFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF
Sbjct: 301 IFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF 360
Query: 361 GRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAAL 420
GRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAAL
Sbjct: 361 GRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAAL 420
Query: 421 QAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG 480
QAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG
Sbjct: 421 QAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG 480
Query: 481 GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFI 540
GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFI
Sbjct: 481 GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFI 540
Query: 541 SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRV 600
SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRV
Sbjct: 541 SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRV 600
Query: 601 INQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKAN 660
INQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKAN
Sbjct: 601 INQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKAN 660
Query: 661 LRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM 720
LRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM
Sbjct: 661 LRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM 720
Query: 721 EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGG 780
EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGG
Sbjct: 721 EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGG 780
Query: 781 AGPSQGSGGGTGGSVYTEDNDDDLYG 806
AGPSQGSGGGTGGSVYTEDNDDDLYG
Sbjct: 781 AGPSQGSGGGTGGSVYTEDNDDDLYG 806
>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
Length = 893
Score = 539 bits (1389), Expect = e-153
Identities = 266/526 (50%), Positives = 374/526 (71%), Gaps = 8/526 (1%)
Query: 190 KREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGT 249
K E+++ +V YD IGG QL I+E++ELPL+ P LFK+ G+ PRG+LLYGPPGT
Sbjct: 339 KNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGT 398
Query: 250 GKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAI 309
GKT+IARAVANE GA+ +INGPEI+SK GE+E+ LR+ F EA P+IIFIDELDA+
Sbjct: 399 GKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDAL 458
Query: 310 APKREKTHGEVERRIVSQLLTLMDGLKQRA---HVIVMAATNRPNSIDPALRRFGRFDRE 366
PKRE EVE+R+V+ LLTLMDG+ V+V+ ATNRP+++D ALRR GRFD+E
Sbjct: 459 CPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKE 518
Query: 367 VDIGIPDATGRLEILQIHTKNMK-LADDVDLEQVANETHGHVGADLAALCSEAALQAIRK 425
++IG+P+A RL+ILQ + + L + +L Q+AN HG+VGADL LC+EA L A+R+
Sbjct: 519 IEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRR 578
Query: 426 KMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDV 485
++ + D +V + +T+ DF A++ PSA+RE ++VP V+W DIGGLE +
Sbjct: 579 ---ILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESI 635
Query: 486 KRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGP 545
K +L++ V++P++HP+ F++ G+ P KGVL YGPPGC KT++AKA+ANE NF++IKGP
Sbjct: 636 KLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGP 695
Query: 546 ELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQIL 605
EL+ + GESE VRE F KAR AP ++FFDELD++A RG ++G G ADRV+ Q+L
Sbjct: 696 ELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLG-AGNVADRVLAQLL 754
Query: 606 TEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSP 665
TEMDG+ K+V I+ ATNRPD ID A++RPGR+D++IY+PLPD +R I K P
Sbjct: 755 TEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMP 814
Query: 666 VAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRER 711
V+ +VDL+ L T+ +SGA++ +C+ A LA+ E I++ + +R
Sbjct: 815 VSNEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANLIMKR 860
>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
Length = 750
Score = 474 bits (1220), Expect = e-133
Identities = 272/619 (43%), Positives = 374/619 (60%), Gaps = 67/619 (10%)
Query: 195 EESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLI 254
E ++ V ++D+GG L ++ +M+ + +RHP ++ +GV PPRG+LL+GPPG GKTL+
Sbjct: 150 EFQISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLL 208
Query: 255 ARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKRE 314
A A+A E + PEI+S ++GESE LR+ FE+A NAP IIFIDE+DAI PKRE
Sbjct: 209 AHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKRE 268
Query: 315 KTHGEVERRIVSQLLTLMDGLKQ---RAHVIVMAATNRPNSIDPALRRFGRFDREVDIGI 371
++ERRIV+QLLT MD L A V+V+ ATNRP+S+DPALRR GRFDRE+ +GI
Sbjct: 269 VASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGI 328
Query: 372 PDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAI-------- 423
PD R ILQ + ++L D +A+ T G VGADL ALC EAA+ A+
Sbjct: 329 PDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQ 388
Query: 424 ---RKKMDLIDL------------------------------EDETIDAEVMNSLAVTMD 450
+K ++ DL + + + E M L + ++
Sbjct: 389 EQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELN 448
Query: 451 DFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTP 510
DF ALS PSA RE V VP VTW DIG LED++ EL + PV +PD+F G+
Sbjct: 449 DFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVT 508
Query: 511 SKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAA 570
GVL GPPGCGKTLLAKA+ANE NFIS+KGPELL M+ GESE VR++F +A+ +A
Sbjct: 509 PAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSA 568
Query: 571 PCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIID 630
PCV+FFDE+D++ R GA+ RV+NQ+LTEMDG+ ++ VFI+ ATNRPDIID
Sbjct: 569 PCVIFFDEVDALCPRRSDR---ETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIID 625
Query: 631 PAILRPGRLDQLIYIPLPDEKSRVAILKA---NLRKSPVAKDVDLEFLA--KMTNGFSGA 685
PAILRPGRLD+ +++ LP R+AILK N K P+ DV+LE +A + ++GA
Sbjct: 626 PAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGA 685
Query: 686 DLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARR 745
DL+ + +RE+ +R+E RQ + + + ++ HFEEA + R
Sbjct: 686 DLSAL--------VREASICALRQEMARQKSGN------EKGELKVSHKHFEEAFKKVRS 731
Query: 746 SVSDNDIRKYEMFAQTLQQ 764
S+S D YE ++L +
Sbjct: 732 SISKKDQIMYERLQESLSR 750
Score = 196 bits (499), Expect = 6e-50
Identities = 108/260 (41%), Positives = 161/260 (61%), Gaps = 6/260 (2%)
Query: 174 CIVAPDTVIHCEG-EPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKA 232
CI D ++ +P + + ++ V + DIG ++ + P+R+P FKA
Sbjct: 444 CIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKA 503
Query: 233 IGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEE 292
+G+ P G+LL GPPG GKTL+A+AVANE+G F + GPE+++ GESE +R+ F+
Sbjct: 504 LGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQR 563
Query: 293 AEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNS 352
A+ +AP +IF DE+DA+ P+R R+V+QLLT MDGL+ R V +MAATNRP+
Sbjct: 564 AKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDI 623
Query: 353 IDPALRRFGRFDREVDIGIPDATGRLEILQIHTKN---MKLADDVDLEQVANETH--GHV 407
IDPA+ R GR D+ + +G+P RL IL+ TKN L DV+LE +A + +
Sbjct: 624 IDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYT 683
Query: 408 GADLAALCSEAALQAIRKKM 427
GADL+AL EA++ A+R++M
Sbjct: 684 GADLSALVREASICALRQEM 703
>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
Length = 856
Score = 474 bits (1220), Expect = e-133
Identities = 272/619 (43%), Positives = 374/619 (60%), Gaps = 67/619 (10%)
Query: 195 EESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLI 254
E ++ V ++D+GG L ++ +M+ + +RHP ++ +GV PPRG+LL+GPPG GKTL+
Sbjct: 256 EFQISNVKFEDVGGNDMTLKEVCKML-IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLL 314
Query: 255 ARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKRE 314
A A+A E + PEI+S ++GESE LR+ FE+A NAP IIFIDE+DAI PKRE
Sbjct: 315 AHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKRE 374
Query: 315 KTHGEVERRIVSQLLTLMDGLKQ---RAHVIVMAATNRPNSIDPALRRFGRFDREVDIGI 371
++ERRIV+QLLT MD L A V+V+ ATNRP+S+DPALRR GRFDRE+ +GI
Sbjct: 375 VASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGI 434
Query: 372 PDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAI-------- 423
PD R ILQ + ++L D +A+ T G VGADL ALC EAA+ A+
Sbjct: 435 PDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQ 494
Query: 424 ---RKKMDLIDL------------------------------EDETIDAEVMNSLAVTMD 450
+K ++ DL + + + E M L + ++
Sbjct: 495 EQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELN 554
Query: 451 DFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTP 510
DF ALS PSA RE V VP VTW DIG LED++ EL + PV +PD+F G+
Sbjct: 555 DFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVT 614
Query: 511 SKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAA 570
GVL GPPGCGKTLLAKA+ANE NFIS+KGPELL M+ GESE VR++F +A+ +A
Sbjct: 615 PAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSA 674
Query: 571 PCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIID 630
PCV+FFDE+D++ R GA+ RV+NQ+LTEMDG+ ++ VFI+ ATNRPDIID
Sbjct: 675 PCVIFFDEVDALCPRRSDR---ETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIID 731
Query: 631 PAILRPGRLDQLIYIPLPDEKSRVAILKA---NLRKSPVAKDVDLEFLA--KMTNGFSGA 685
PAILRPGRLD+ +++ LP R+AILK N K P+ DV+LE +A + ++GA
Sbjct: 732 PAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGA 791
Query: 686 DLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARR 745
DL+ + +RE+ +R+E RQ + + + ++ HFEEA + R
Sbjct: 792 DLSAL--------VREASICALRQEMARQKSGN------EKGELKVSHKHFEEAFKKVRS 837
Query: 746 SVSDNDIRKYEMFAQTLQQ 764
S+S D YE ++L +
Sbjct: 838 SISKKDQIMYERLQESLSR 856
Score = 196 bits (499), Expect = 6e-50
Identities = 108/260 (41%), Positives = 161/260 (61%), Gaps = 6/260 (2%)
Query: 174 CIVAPDTVIHCEG-EPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKA 232
CI D ++ +P + + ++ V + DIG ++ + P+R+P FKA
Sbjct: 550 CIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKA 609
Query: 233 IGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEE 292
+G+ P G+LL GPPG GKTL+A+AVANE+G F + GPE+++ GESE +R+ F+
Sbjct: 610 LGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQR 669
Query: 293 AEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNS 352
A+ +AP +IF DE+DA+ P+R R+V+QLLT MDGL+ R V +MAATNRP+
Sbjct: 670 AKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDI 729
Query: 353 IDPALRRFGRFDREVDIGIPDATGRLEILQIHTKN---MKLADDVDLEQVANETH--GHV 407
IDPA+ R GR D+ + +G+P RL IL+ TKN L DV+LE +A + +
Sbjct: 730 IDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYT 789
Query: 408 GADLAALCSEAALQAIRKKM 427
GADL+AL EA++ A+R++M
Sbjct: 790 GADLSALVREASICALRQEM 809
>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
Length = 753
Score = 425 bits (1093), Expect = e-119
Identities = 256/683 (37%), Positives = 380/683 (55%), Gaps = 76/683 (11%)
Query: 104 PCPDVKYGKRIHVLPIDDTVEGITG--NLFEVYLKPYFLEAYRPIRKGDIFLVRGG---- 157
PCP ++ R+ V P+ G G N V L RPI G + + G
Sbjct: 103 PCPPLR---RVAVWPVLRERAGAPGARNTAAVLEAAQELLRNRPISLGHVVVAPPGAPGL 159
Query: 158 MRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIK 217
+ A+ P P +V P T + GEP E + EV +GG + ++
Sbjct: 160 VAALHIVGGTPSPDPAGLVTPRTRVSLGGEP---PSEAQPQPEV---PLGGLSEAADSLR 213
Query: 218 EMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSK 277
E++ LPLR+P A+G+ PRG+LL GPPG GKT + RAVA E GA ++ P +
Sbjct: 214 ELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGS 273
Query: 278 LAGESESNLRKAFEEAEKNA---PAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDG 334
GE+E N+R+ F+ A + A P+++F+DE+DA+ P+R E R+V+Q+LTL+DG
Sbjct: 274 RPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSR--APESRVVAQVLTLLDG 331
Query: 335 LKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDV 394
V+V+ ATNRP+++DPALRR GRFDREV IG P R EILQ+ T M ++ V
Sbjct: 332 ASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPISSHV 391
Query: 395 DLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRW 454
DL +A T G+VGADL ALC EAA+ A+ ++ D V++ + DF
Sbjct: 392 DLGLLAEMTVGYVGADLTALCREAAMHALLHS-------EKNQDNPVIDEI-----DFLE 439
Query: 455 ALSQSNPSALRETV--VEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSK 512
A PS+ R + +++ V WE+IGGLEDVK +L++ +++P++ P +F++ G+T K
Sbjct: 440 AFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPK 499
Query: 513 GVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPC 572
GVL YGPPGC KT L +A+A C +F+S+ G +L + + G+SE + +IF +AR + P
Sbjct: 500 GVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPA 559
Query: 573 VLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTK------------------ 614
+LF DE+DSI AR + G +RV++ +L E+DG+ K
Sbjct: 560 ILFLDEIDSILGARSAS-KTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVF 618
Query: 615 -KNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLE 673
++V II ATNRPD++D A+LRPGRLD++IYIP PD K R++ILK + P+ DV LE
Sbjct: 619 NRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLE 678
Query: 674 FLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRR 733
LA T FSGADL +C A LA++E+ +++
Sbjct: 679 NLAAETCFFSGADLRNLCTEAALLALQEN----------------------GLDATTVKQ 716
Query: 734 DHFEEAMRFARRSVSDNDIRKYE 756
+HF ++++ + S+S D+ YE
Sbjct: 717 EHFLKSLKTVKPSLSCKDLALYE 739
>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
Length = 980
Score = 297 bits (760), Expect = 3e-80
Identities = 185/524 (35%), Positives = 290/524 (55%), Gaps = 26/524 (4%)
Query: 241 ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI 300
+LL GPPG GKT + A + G + + ++ +G E+ L+ F A + PA+
Sbjct: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
Query: 301 IFIDELDAIAPKREKTHGEVER--RIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALR 358
+ + +D + R+ GE R ++ LL D L ++V+A T+R + ++
Sbjct: 526 LLLTAVDLLGRDRDGL-GEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQ 584
Query: 359 RFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALC--- 415
F E+++ RL IL+ T ++ L +V+L Q+A G V DL AL
Sbjct: 585 T--AFPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHS 642
Query: 416 SEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRET-VVEVPQV 474
S AA I+ L +E + +DF AL Q + + ++P V
Sbjct: 643 SRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAVGAPKIPSV 702
Query: 475 TWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANE 534
+W D+GGL++VK+E+ E +Q P+EHP+ L G+ S G+L +GPPG GKTLLAKA+A E
Sbjct: 703 SWHDVGGLQEVKKEILETIQLPLEHPE-LLSLGLRRS-GLLLHGPPGTGKTLLAKAVATE 760
Query: 535 CQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGG 594
C F+S+KGPEL+ M+ G+SE NVRE+F +AR AAPC++FFDELDS+A +RG + GD G
Sbjct: 761 CSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRS-GDSG 819
Query: 595 GAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPL-PDEKSR 653
G DRV++Q+L E+DG+ + ++VF+IGATNRPD++DPA+LRPGR D+L+++ D S+
Sbjct: 820 GVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQ 879
Query: 654 VAILKANLRKSPVAKDVDL-EFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERE 712
+ +L A RK + V L L +GADL +C A A++ + E
Sbjct: 880 LRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHD---LEEG 936
Query: 713 RQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYE 756
+ SA+ + +D + +A + SVS+ ++ +Y+
Sbjct: 937 LEPGSSALMLTMEDLL---------QAAARLQPSVSEQELLRYK 971
Score = 184 bits (466), Expect = 4e-46
Identities = 110/278 (39%), Positives = 167/278 (60%), Gaps = 10/278 (3%)
Query: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260
V + D+GG ++ +I E ++LPL HP L ++G++ G+LL+GPPGTGKTL+A+AVA
Sbjct: 702 VSWHDVGGLQEVKKEILETIQLPLEHPELL-SLGLRRS-GLLLHGPPGTGKTLLAKAVAT 759
Query: 261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKT--HG 318
E F + GPE+++ G+SE N+R+ F A AP IIF DELD++AP R ++ G
Sbjct: 760 ECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSG 819
Query: 319 EVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGI-PDATGR 377
V R+VSQLL +DGL V V+ ATNRP+ +DPAL R GRFD+ V +G D +
Sbjct: 820 GVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQ 879
Query: 378 LEILQIHTKNMKLADDVDLEQVANETHGHV-GADLAALCSEAALQAIRKKMDLIDLEDET 436
L +L T+ KL V L V + + GADL +LCS+A A+++++ DLE+
Sbjct: 880 LRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVH--DLEEGL 937
Query: 437 IDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQV 474
++L +TM+D A ++ PS + ++ ++
Sbjct: 938 EPGS--SALMLTMEDLLQAAARLQPSVSEQELLRYKRI 973
Score = 71.2 bits (173), Expect = 3e-12
Identities = 51/191 (26%), Positives = 90/191 (47%), Gaps = 4/191 (2%)
Query: 508 MTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKAR 567
+T + VL GPPGCGKT + A + + + + L G E ++ IF +AR
Sbjct: 460 LTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRAR 519
Query: 568 QAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPD 627
+ P VL +D + + R G D A V+ +L D +++ + ++ T+R
Sbjct: 520 RCRPAVLLLTAVDLLGRDRDGLGEDARVMA--VLRHLLLNEDPLNSCPPLMVVATTSRAQ 577
Query: 628 IIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADL 687
+ PA ++ +L +P E R++IL+A P+ ++V+L LA+ GF DL
Sbjct: 578 DL-PADVQTAFPHEL-EVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDL 635
Query: 688 TEICQRACKLA 698
+ + + A
Sbjct: 636 YALLTHSSRAA 646
>gi|4505725 peroxin1 [Homo sapiens]
Length = 1283
Score = 273 bits (699), Expect = 4e-73
Identities = 172/474 (36%), Positives = 257/474 (54%), Gaps = 34/474 (7%)
Query: 241 ILLYGPPGTGKTLIARAVANET----GAFFFLINGPEIMSKLAGESESNLRKAFEEAEKN 296
+LL G G+GK+ +A+A+ E A ++ + K + L AF EA
Sbjct: 595 LLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWM 654
Query: 297 APAIIFIDELDAIA-----PKREKTHGEVERRIVSQLLTLM--DGLKQRAHVIVMAATNR 349
P+++ +D+LD IA P+ E + V+ + ++ L M + + + V ++A +
Sbjct: 655 QPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQS 714
Query: 350 PNSIDPAL---RRFGRFDREVDIGIPDATGRLEILQIHTKNMKLAD-----DVDLEQVAN 401
S+ P L + F I P+ R EIL KN D D+DL+ VA
Sbjct: 715 QQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAK 774
Query: 402 ETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNP 461
ET G V D L A + ++ L +T DF+ AL P
Sbjct: 775 ETGGFVARDFTVLVDRAIHSRLSRQ-----------SISTREKLVLTTLDFQKALRGFLP 823
Query: 462 SALRETVVEVPQ-VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPP 520
++LR + P+ + W+ IGGL +V++ L + +Q P ++P+ F + G+L YGPP
Sbjct: 824 ASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPP 883
Query: 521 GCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELD 580
G GKTLLA IA E + NFIS+KGPELL+ + G SE VR+IF +A+ A PC+LFFDE +
Sbjct: 884 GTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFE 943
Query: 581 SIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLD 640
SIA RG D G DRV+NQ+LT++DG+ + V+++ AT+RPD+IDPA+LRPGRLD
Sbjct: 944 SIAPRRG---HDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLD 1000
Query: 641 QLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRA 694
+ +Y P PD+ SR+ IL P+A DVDL+ +A +T+ F+GADL + A
Sbjct: 1001 KCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNA 1054
Score = 190 bits (482), Expect = 5e-48
Identities = 104/247 (42%), Positives = 153/247 (61%)
Query: 200 EVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVA 259
++G+D IGG + + + ++LP ++P LF + ++ GILLYGPPGTGKTL+A +A
Sbjct: 836 DLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIA 895
Query: 260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGE 319
E+ F + GPE++SK G SE +R F A+ P I+F DE ++IAP+R +
Sbjct: 896 RESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTG 955
Query: 320 VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLE 379
V R+V+QLLT +DG++ V V+AAT+RP+ IDPAL R GR D+ V PD RLE
Sbjct: 956 VTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLE 1015
Query: 380 ILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDA 439
IL + + ++ LADDVDL+ VA+ T GADL AL A L+A+ + L+D + +
Sbjct: 1016 ILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSS 1075
Query: 440 EVMNSLA 446
+ SL+
Sbjct: 1076 DSDLSLS 1082
>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
Length = 1390
Score = 223 bits (569), Expect = 4e-58
Identities = 119/273 (43%), Positives = 171/273 (62%), Gaps = 7/273 (2%)
Query: 199 NEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAV 258
+ V +D +GG +A +KEMV PL +P +F+ ++PPRG L YGPPGTGKTL+ARA+
Sbjct: 421 SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL 480
Query: 259 ANETG-----AFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR 313
ANE FF+ G + +SK GESE LR F++A + P+IIF DE+D +AP R
Sbjct: 481 ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR 540
Query: 314 EKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPD 373
++ IVS LL LMDGL R ++V+ ATNR +SIDPALRR GRFDRE +PD
Sbjct: 541 SSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPD 600
Query: 374 ATGRLEILQIHTKNMKLAD-DVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDL 432
R EIL+IHT++ D LE++A G+ GAD+ ++C+EAAL A+R++ I
Sbjct: 601 KEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYT 660
Query: 433 EDETIDAEVMNSLAVTMDDFRWALSQSNPSALR 465
E + + ++S+ ++ DF A+ + P++ R
Sbjct: 661 TSEKLQLD-LSSINISAKDFEVAMQKMIPASQR 692
Score = 182 bits (461), Expect = 1e-45
Identities = 99/259 (38%), Positives = 149/259 (57%), Gaps = 9/259 (3%)
Query: 474 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIAN 533
V ++ +GGL + L+E+V +P+ +P+ F KF + P +G LFYGPPG GKTL+A+A+AN
Sbjct: 423 VRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 482
Query: 534 EC-----QANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGG 588
EC + F KG + L+ W GESE +R +FD+A Q P ++FFDE+D +A R
Sbjct: 483 ECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSS 542
Query: 589 NIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLP 648
+++ +L MDG+ ++ + +IGATNR D IDPA+ RPGR D+ LP
Sbjct: 543 RQDQ---IHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLP 599
Query: 649 DEKSRVAILKANLRK-SPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEI 707
D+++R ILK + R +P D LE LA+ G+ GAD+ IC A A+R
Sbjct: 600 DKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIY 659
Query: 708 RRERERQTNPSAMEVEEDD 726
+ Q + S++ + D
Sbjct: 660 TTSEKLQLDLSSINISAKD 678
Score = 37.0 bits (84), Expect = 0.073
Identities = 45/205 (21%), Positives = 86/205 (41%), Gaps = 38/205 (18%)
Query: 222 LPLRHPALFKAIGVKPPRGILLYGPPGTGK-TLIARAVANETGAF-FFLINGPEIMSKLA 279
L L A ++ + +P IL+ G PG G+ + +A AV + F + ++ P +
Sbjct: 778 LHLNRNACYQPMSFRPR--ILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVST 835
Query: 280 GESESNLRKAFEEAEKNAPAIIFIDEL----DAIAPKREKTHGEVERRIVSQLLTLMDGL 335
E + EA++ AP+I+++ + + + P + T TL+ +
Sbjct: 836 TSPEETCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKAT-----------FTTLLQNI 884
Query: 336 KQRAHVIVMAATNRPNSIDPA------LRRFGRFDREVDIGIPDATGRLEILQIHTKNMK 389
A V+++A +++P+S P +R +G ++ +PD R K
Sbjct: 885 PSFAPVLLLATSDKPHSALPEEVQELFIRDYGEI---FNVQLPDKEER----------TK 931
Query: 390 LADDVDLEQVANETHGHVGADLAAL 414
+D+ L+Q A A L AL
Sbjct: 932 FFEDLILKQAAKPPISKKKAVLQAL 956
>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
Length = 1458
Score = 220 bits (560), Expect = 5e-57
Identities = 123/272 (45%), Positives = 168/272 (61%), Gaps = 9/272 (3%)
Query: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260
V +D IGG + +KEMV PL +P +F+ ++PPRG L YGPPGTGKTL+ARA+AN
Sbjct: 397 VRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 456
Query: 261 ETG-----AFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREK 315
E FF+ G + +SK GESE LR F++A P+IIF DE+D +AP R
Sbjct: 457 ECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS 516
Query: 316 THGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDAT 375
++ IVS LL LMDGL R ++V+ ATNR +SIDPALRR GRFDRE +PD
Sbjct: 517 RQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQK 576
Query: 376 GRLEILQIHTK--NMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLE 433
R ILQIHT+ N KL+ D L ++A + G+ GAD+ ALC+EAAL A+R++ I
Sbjct: 577 ARKHILQIHTRDWNPKLS-DAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYAS 635
Query: 434 DETIDAEVMNSLAVTMDDFRWALSQSNPSALR 465
+ +V +S+ ++ DF A+ P++ R
Sbjct: 636 SHKLQLDV-SSIVLSAQDFYHAMQNIVPASQR 666
Score = 176 bits (445), Expect = 1e-43
Identities = 97/259 (37%), Positives = 146/259 (56%), Gaps = 9/259 (3%)
Query: 474 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIAN 533
V ++ IGGL L+E+V +P+ +P+ F KF + P +G LFYGPPG GKTL+A+A+AN
Sbjct: 397 VRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALAN 456
Query: 534 EC-----QANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGG 588
EC + F KG + L+ W GESE +R +FD+A P ++FFDE+D +A R
Sbjct: 457 ECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSS 516
Query: 589 NIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLP 648
+++ +L MDG+ + + +IGATNR D IDPA+ RPGR D+ LP
Sbjct: 517 RQDQ---IHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLP 573
Query: 649 DEKSRVAILKANLRK-SPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEI 707
D+K+R IL+ + R +P D L LA+ G+ GAD+ +C A +A+R
Sbjct: 574 DQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIY 633
Query: 708 RRERERQTNPSAMEVEEDD 726
+ Q + S++ + D
Sbjct: 634 ASSHKLQLDVSSIVLSAQD 652
>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
Length = 440
Score = 215 bits (547), Expect = 1e-55
Identities = 112/257 (43%), Positives = 163/257 (63%), Gaps = 3/257 (1%)
Query: 181 VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRG 240
V+ + +P+ + E + Y DIGG Q+ +IKE VELPL HP ++ +G+KPP+G
Sbjct: 162 VLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKG 221
Query: 241 ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI 300
++LYGPPGTGKTL+A+AVAN+T A F + G E++ K G+ +R+ F AE++AP+I
Sbjct: 222 VILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSI 281
Query: 301 IFIDELDAIAPKREKTHGEVER---RIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPAL 357
+FIDE+DAI KR ++ ER R + +LL +DG R V V+ ATNR ++DPAL
Sbjct: 282 VFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPAL 341
Query: 358 RRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSE 417
R GR DR+++ +PD + I QIHT M LADDV L+ + GAD+ A+C+E
Sbjct: 342 IRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTE 401
Query: 418 AALQAIRKKMDLIDLED 434
A L A+R++ + ED
Sbjct: 402 AGLMALRERRMKVTNED 418
Score = 199 bits (507), Expect = 7e-51
Identities = 110/307 (35%), Positives = 180/307 (58%), Gaps = 10/307 (3%)
Query: 396 LEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETI-DAEVMNSLAVTMDDFRW 454
LE++ ++ H V + + + L + K DL++ + + +V + V MDD
Sbjct: 112 LEEIIDDNHAIVSTSVGSEHYVSILSFVDK--DLLEPGCSVLLNHKVHAVIGVLMDD--- 166
Query: 455 ALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGV 514
++P V + PQ T+ DIGGL++ +E++E V+ P+ HP+ + + G+ P KGV
Sbjct: 167 ----TDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGV 222
Query: 515 LFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVL 574
+ YGPPG GKTLLAKA+AN+ A F+ + G EL+ + G+ VRE+F A + AP ++
Sbjct: 223 ILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIV 282
Query: 575 FFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAIL 634
F DE+D+I R + G R + ++L ++DG ++ +V +I ATNR + +DPA++
Sbjct: 283 FIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALI 342
Query: 635 RPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRA 694
RPGR+D+ I PLPDEK++ I + + + +A DV L+ L + SGAD+ IC A
Sbjct: 343 RPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEA 402
Query: 695 CKLAIRE 701
+A+RE
Sbjct: 403 GLMALRE 409
>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
Length = 433
Score = 208 bits (529), Expect = 2e-53
Identities = 103/277 (37%), Positives = 164/277 (59%), Gaps = 5/277 (1%)
Query: 429 LIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVV-----EVPQVTWEDIGGLE 483
++DL D+ ++ + V +D ++ + P + TV E P VT+ D+GG +
Sbjct: 122 VVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCK 181
Query: 484 DVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIK 543
+ +L+E+V+ P+ HP++F+ G+ P KGVL +GPPG GKTL A+A+AN A FI +
Sbjct: 182 EQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVI 241
Query: 544 GPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQ 603
G EL+ + GE VRE+F+ AR C++FFDE+D+I AR + G R + +
Sbjct: 242 GSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLE 301
Query: 604 ILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRK 663
++ ++DG + N+ ++ ATNRPD +DPA++RPGRLD+ I LPD + R I K + R
Sbjct: 302 LINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARS 361
Query: 664 SPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIR 700
V +D+ E LA++ +GA++ +C A AIR
Sbjct: 362 MSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIR 398
Score = 200 bits (508), Expect = 5e-51
Identities = 99/242 (40%), Positives = 153/242 (63%), Gaps = 3/242 (1%)
Query: 196 ESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIA 255
E +V Y D+GGC++Q+ +++E+VE PL HP F +G++PP+G+LL+GPPGTGKTL A
Sbjct: 167 EEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCA 226
Query: 256 RAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR-- 313
RAVAN T A F + G E++ K GE +R+ FE A +IF DE+DAI R
Sbjct: 227 RAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFD 286
Query: 314 EKTHGEVE-RRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIP 372
+ G+ E +R + +L+ +DG R ++ V+ ATNRP+++DPAL R GR DR+++ +P
Sbjct: 287 DGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLP 346
Query: 373 DATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDL 432
D GR I +IH ++M + D+ E +A GA++ ++C+EA + AIR + +
Sbjct: 347 DLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATE 406
Query: 433 ED 434
+D
Sbjct: 407 KD 408
>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
Length = 406
Score = 202 bits (514), Expect = 1e-51
Identities = 115/312 (36%), Positives = 184/312 (58%), Gaps = 10/312 (3%)
Query: 398 QVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDA-EVMNSLAVTMDDFRWAL 456
Q+ E +VG + A+ + L + + + D+ ID +V + V + + + L
Sbjct: 64 QLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTL 123
Query: 457 SQSNPSALRETVV-----EVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPS 511
+ P+ + V +VP T+E IGGL+ +E++E+++ PV+HP+ F G+
Sbjct: 124 HKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQP 183
Query: 512 KGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAP 571
KGVL YGPPG GKTLLA+A+A+ FI + G EL+ + GE VRE+F AR+ AP
Sbjct: 184 KGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAP 243
Query: 572 CVLFFDELDSIAKAR--GGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDII 629
++F DE+DSI +R GG+ GD R + ++L ++DG KN+ +I ATNR DI+
Sbjct: 244 SIIFMDEIDSIGSSRLEGGSGGD--SEVQRTMLELLNQLDGFEATKNIKVIMATNRIDIL 301
Query: 630 DPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTE 689
D A+LRPGR+D+ I P P+E++R+ ILK + RK + + ++L +A++ G SGA++
Sbjct: 302 DSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKG 361
Query: 690 ICQRACKLAIRE 701
+C A A+RE
Sbjct: 362 VCTEAGMYALRE 373
Score = 196 bits (497), Expect = 9e-50
Identities = 103/251 (41%), Positives = 166/251 (66%), Gaps = 4/251 (1%)
Query: 196 ESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIA 255
E + + Y+ IGG KQ+ +IKE++ELP++HP LF+A+G+ P+G+LLYGPPGTGKTL+A
Sbjct: 141 EKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLA 200
Query: 256 RAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREK 315
RAVA+ T F ++G E++ K GE +R+ F A ++AP+IIF+DE+D+I R +
Sbjct: 201 RAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLE 260
Query: 316 --THGEVE-RRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIP 372
+ G+ E +R + +LL +DG + ++ V+ ATNR + +D AL R GR DR+++ P
Sbjct: 261 GGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPP 320
Query: 373 DATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDL 432
+ RL+IL+IH++ M L ++L ++A G GA++ +C+EA + A+R++ +
Sbjct: 321 NEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQ 380
Query: 433 ED-ETIDAEVM 442
ED E A+VM
Sbjct: 381 EDFEMAVAKVM 391
>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
Length = 403
Score = 202 bits (514), Expect = 1e-51
Identities = 111/283 (39%), Positives = 174/283 (61%), Gaps = 16/283 (5%)
Query: 424 RKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLE 483
R+++D L+ T A M +L + R+ + +P + + V++ +IGGL
Sbjct: 98 RRQLDKSKLKPGTRVALDMTTLTI----MRYLPREVDPLVYNMSHEDPGNVSYSEIGGLS 153
Query: 484 DVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIK 543
+ REL+E+++ P+ +P+ F + G+ P KG L YGPPG GKTLLA+A+A++ NF+ +
Sbjct: 154 EQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVV 213
Query: 544 GPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVIN- 602
++ + GES +RE+F+ AR PC++F DE+D+I GG G +ADR I
Sbjct: 214 SSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAI----GGRRFSEGTSADREIQR 269
Query: 603 ---QILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKA 659
++L +MDG T V +I ATNRPD +DPA+LRPGRLD+ I+I LP+E++R+ ILK
Sbjct: 270 TLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILK- 328
Query: 660 NLRKSPVAK--DVDLEFLAKMTNGFSGADLTEICQRACKLAIR 700
+ P+ K ++D E + K+++GF+GADL +C A AIR
Sbjct: 329 -IHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIR 370
Score = 196 bits (497), Expect = 9e-50
Identities = 105/253 (41%), Positives = 155/253 (61%), Gaps = 3/253 (1%)
Query: 185 EGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLY 244
E +P+ E V Y +IGG +Q+ +++E++ELPL +P LF+ +G+ PP+G LLY
Sbjct: 128 EVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLY 187
Query: 245 GPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFID 304
GPPGTGKTL+ARAVA++ F + I+ K GES +R+ F A + P IIF+D
Sbjct: 188 GPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMD 247
Query: 305 ELDAIAPKR--EKTHGEVE-RRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFG 361
E+DAI +R E T + E +R + +LL MDG V ++ ATNRP+++DPAL R G
Sbjct: 248 EIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPG 307
Query: 362 RFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQ 421
R DR++ I +P+ RL+IL+IH + ++D E + + G GADL +C+EA +
Sbjct: 308 RLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMF 367
Query: 422 AIRKKMDLIDLED 434
AIR D + ED
Sbjct: 368 AIRADHDFVVQED 380
>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
Length = 797
Score = 199 bits (505), Expect = 1e-50
Identities = 106/237 (44%), Positives = 146/237 (61%), Gaps = 7/237 (2%)
Query: 474 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIAN 533
V ++D+ G E+ K E+ E V + +++P ++ G KG + GPPG GKTLLAKA A
Sbjct: 305 VKFKDVAGCEEAKLEIMEFVNF-LKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAG 363
Query: 534 ECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARG-GNIGD 592
E FI++ G E L M+ G A VR++F AR+ APC+LF DE+D++ + RG GN G
Sbjct: 364 EANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFG- 422
Query: 593 GGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKS 652
G + +NQ+L EMDG +T NV I+ TNRPDI+DPA+LRPGR D+ I+I PD K
Sbjct: 423 GQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKG 482
Query: 653 RVAILKANLR----KSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIES 705
R +I K +LR S + KD LA +T GFSGAD+ +C A +A R +S
Sbjct: 483 RASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDS 539
Score = 180 bits (456), Expect = 5e-45
Identities = 97/239 (40%), Positives = 147/239 (61%), Gaps = 8/239 (3%)
Query: 200 EVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVA 259
+V + D+ GC + +I E V L++P ++ +G K P+G +L GPPGTGKTL+A+A A
Sbjct: 304 DVKFKDVAGCEEAKLEIMEFVNF-LKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATA 362
Query: 260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTH-- 317
E F ++G E + G + +R F A KNAP I+FIDE+DA+ KR + +
Sbjct: 363 GEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFG 422
Query: 318 GEVER-RIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376
G+ E+ ++QLL MDG +V+++A TNRP+ +DPAL R GRFDR++ IG PD G
Sbjct: 423 GQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKG 482
Query: 377 RLEILQIHTKNMKLADDVDLEQVANE----THGHVGADLAALCSEAALQAIRKKMDLID 431
R I ++H + +KL ++ +++A + T G GAD+A +C+EAAL A R D I+
Sbjct: 483 RASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSIN 541
>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
Length = 439
Score = 196 bits (498), Expect = 7e-50
Identities = 123/365 (33%), Positives = 198/365 (54%), Gaps = 29/365 (7%)
Query: 78 SDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKP 137
+ EKI++N+ + L + +++ + P + G I +D +G + +
Sbjct: 76 NSEKIKVNKTLPY-LVSNVIELLDVDPNDQEEDGANID---LDSQRKGKCAVIKTSTRQT 131
Query: 138 YFLEAY-----RPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKRE 192
YFL ++ GD+ G+ + ++ET P+ Y +K
Sbjct: 132 YFLPVIGLVDAEKLKPGDLV----GVNKDSYLILETLPTEY------------DSRVKAM 175
Query: 193 DEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKT 252
+ +E E Y DIGG KQ+ ++ E + LP+ H F+ +G++PP+G+L+YGPPGTGKT
Sbjct: 176 EVDERPTEQ-YSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKT 234
Query: 253 LIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPK 312
L+ARA A +T A F + GP+++ G+ +R AF A++ AP+IIFIDELDAI K
Sbjct: 235 LLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTK 294
Query: 313 R---EKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDI 369
R EK +R + +LL +DG + V V+AATNR + +DPAL R GR DR+++
Sbjct: 295 RFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEF 354
Query: 370 GIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDL 429
+P+ R I+QIH++ M ++ DV+ E++A T GA A+C EA + A+R+
Sbjct: 355 PMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATE 414
Query: 430 IDLED 434
+ ED
Sbjct: 415 LTHED 419
Score = 192 bits (488), Expect = 1e-48
Identities = 98/233 (42%), Positives = 145/233 (62%)
Query: 468 VVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLL 527
V E P + DIGGL+ +EL E + P+ H +KF G+ P KGVL YGPPG GKTLL
Sbjct: 177 VDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLL 236
Query: 528 AKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARG 587
A+A A + +A F+ + GP+L+ M+ G+ VR+ F A++ AP ++F DELD+I R
Sbjct: 237 ARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRF 296
Query: 588 GNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPL 647
+ G R + ++L ++DG V +I ATNR DI+DPA+LR GRLD+ I P+
Sbjct: 297 DSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPM 356
Query: 648 PDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIR 700
P+E++R I++ + RK V+ DV+ E LA+ T+ F+GA +C A +A+R
Sbjct: 357 PNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALR 409
>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
[Homo sapiens]
Length = 414
Score = 195 bits (496), Expect = 1e-49
Identities = 98/245 (40%), Positives = 150/245 (61%)
Query: 458 QSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFY 517
+++ S + T + P V + DIGG++ K+E++E V+ P+ H + + + G+ P +GVL Y
Sbjct: 142 EADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMY 201
Query: 518 GPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFD 577
GPPGCGKT+LAKA+A+ A FI + G E + + GE VR++F A++ AP ++F D
Sbjct: 202 GPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFID 261
Query: 578 ELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPG 637
E+D+IA R R++ ++L +MDG NV +I ATNR D +DPA+LRPG
Sbjct: 262 EIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPG 321
Query: 638 RLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKL 697
RLD+ I PLPD + + I K ++++VDLE + SGAD+ ICQ + L
Sbjct: 322 RLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGML 381
Query: 698 AIRES 702
A+RE+
Sbjct: 382 AVREN 386
Score = 195 bits (495), Expect = 2e-49
Identities = 104/238 (43%), Positives = 148/238 (62%), Gaps = 3/238 (1%)
Query: 200 EVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVA 259
+V Y DIGG Q +++E VELPL H L+K IG+ PPRG+L+YGPPG GKT++A+AVA
Sbjct: 157 DVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVA 216
Query: 260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGE 319
+ T A F + G E + K GE +R F A++NAPAIIFIDE+DAIA KR
Sbjct: 217 HHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTG 276
Query: 320 VER---RIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376
+R RI+ +LL MDG Q +V V+ ATNR +++DPAL R GR DR+++ +PD
Sbjct: 277 ADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 336
Query: 377 RLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLED 434
+ I T M L+++VDLE GAD+ ++C E+ + A+R+ ++ +D
Sbjct: 337 KRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKD 394
>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
sapiens]
Length = 387
Score = 195 bits (496), Expect = 1e-49
Identities = 98/245 (40%), Positives = 150/245 (61%)
Query: 458 QSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFY 517
+++ S + T + P V + DIGG++ K+E++E V+ P+ H + + + G+ P +GVL Y
Sbjct: 115 EADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMY 174
Query: 518 GPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFD 577
GPPGCGKT+LAKA+A+ A FI + G E + + GE VR++F A++ AP ++F D
Sbjct: 175 GPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFID 234
Query: 578 ELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPG 637
E+D+IA R R++ ++L +MDG NV +I ATNR D +DPA+LRPG
Sbjct: 235 EIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPG 294
Query: 638 RLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKL 697
RLD+ I PLPD + + I K ++++VDLE + SGAD+ ICQ + L
Sbjct: 295 RLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGML 354
Query: 698 AIRES 702
A+RE+
Sbjct: 355 AVREN 359
Score = 195 bits (495), Expect = 2e-49
Identities = 104/238 (43%), Positives = 148/238 (62%), Gaps = 3/238 (1%)
Query: 200 EVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVA 259
+V Y DIGG Q +++E VELPL H L+K IG+ PPRG+L+YGPPG GKT++A+AVA
Sbjct: 130 DVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVA 189
Query: 260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGE 319
+ T A F + G E + K GE +R F A++NAPAIIFIDE+DAIA KR
Sbjct: 190 HHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTG 249
Query: 320 VER---RIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376
+R RI+ +LL MDG Q +V V+ ATNR +++DPAL R GR DR+++ +PD
Sbjct: 250 ADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 309
Query: 377 RLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLED 434
+ I T M L+++VDLE GAD+ ++C E+ + A+R+ ++ +D
Sbjct: 310 KRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKD 367
>gi|5729991 proteasome 26S ATPase subunit 4 isoform 1 [Homo sapiens]
Length = 418
Score = 195 bits (496), Expect = 1e-49
Identities = 98/245 (40%), Positives = 150/245 (61%)
Query: 458 QSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFY 517
+++ S + T + P V + DIGG++ K+E++E V+ P+ H + + + G+ P +GVL Y
Sbjct: 146 EADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMY 205
Query: 518 GPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFD 577
GPPGCGKT+LAKA+A+ A FI + G E + + GE VR++F A++ AP ++F D
Sbjct: 206 GPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFID 265
Query: 578 ELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPG 637
E+D+IA R R++ ++L +MDG NV +I ATNR D +DPA+LRPG
Sbjct: 266 EIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPG 325
Query: 638 RLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKL 697
RLD+ I PLPD + + I K ++++VDLE + SGAD+ ICQ + L
Sbjct: 326 RLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGML 385
Query: 698 AIRES 702
A+RE+
Sbjct: 386 AVREN 390
Score = 195 bits (495), Expect = 2e-49
Identities = 104/238 (43%), Positives = 148/238 (62%), Gaps = 3/238 (1%)
Query: 200 EVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVA 259
+V Y DIGG Q +++E VELPL H L+K IG+ PPRG+L+YGPPG GKT++A+AVA
Sbjct: 161 DVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVA 220
Query: 260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGE 319
+ T A F + G E + K GE +R F A++NAPAIIFIDE+DAIA KR
Sbjct: 221 HHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTG 280
Query: 320 VER---RIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376
+R RI+ +LL MDG Q +V V+ ATNR +++DPAL R GR DR+++ +PD
Sbjct: 281 ADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQ 340
Query: 377 RLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLED 434
+ I T M L+++VDLE GAD+ ++C E+ + A+R+ ++ +D
Sbjct: 341 KRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKD 398
>gi|156564401 vesicle-fusing ATPase [Homo sapiens]
Length = 744
Score = 189 bits (480), Expect = 9e-48
Identities = 148/446 (33%), Positives = 229/446 (51%), Gaps = 35/446 (7%)
Query: 206 IGGCRKQLAQI-KEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGA 264
IGG K+ + I + + P + + +G K +GILLYGPPG GKTL+AR + A
Sbjct: 220 IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA 279
Query: 265 FF-FLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKREK 315
++NGPEI++K GESE+N+RK F +AE+ II DE+DAI +R
Sbjct: 280 REPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGS 339
Query: 316 THGE--VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPD 373
G V +V+QLL+ +DG++Q +++V+ TNRP+ ID AL R GR + +++IG+PD
Sbjct: 340 MAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPD 399
Query: 374 ATGRLEILQIHTKNMK----LADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDL 429
GRL+IL IHT M+ L+ DVD++++A ET GA+L L A A+ + +
Sbjct: 400 EKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKA 459
Query: 430 IDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLED-VKRE 488
+ +D E SL VT DF +L A + I D V R
Sbjct: 460 STKVE--VDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRV 517
Query: 489 LQ--ELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPE 546
L EL+ ++ D+ TP VL GPP GKT LA IA E FI I P+
Sbjct: 518 LDDGELLVQQTKNSDR------TPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD 571
Query: 547 LLTMWFGESE--ANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQI 604
+ + F E+ +++IFD A ++ + D+++ + + G ++ V+ +
Sbjct: 572 KM-IGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLL----DYVPIGPRFSNLVLQAL 626
Query: 605 LTEMDGMSTK-KNVFIIGATNRPDII 629
L + + + + IIG T+R D++
Sbjct: 627 LVLLKKAPPQGRKLLIIGTTSRKDVL 652
Score = 160 bits (404), Expect = 6e-39
Identities = 100/273 (36%), Positives = 152/273 (55%), Gaps = 22/273 (8%)
Query: 479 IGGLE----DVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANE 534
IGGL+ D+ R +P P+ + G KG+L YGPPGCGKTLLA+ I
Sbjct: 220 IGGLDKEFSDIFRRAFASRVFP---PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKM 276
Query: 535 CQANFISI-KGPELLTMWFGESEANVREIFDKARQ--------AAPCVLFFDELDSIAKA 585
A + GPE+L + GESEAN+R++F A + + ++ FDE+D+I K
Sbjct: 277 LNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQ 336
Query: 586 RGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI 645
RG G G D V+NQ+L+++DG+ N+ +IG TNRPD+ID A+LRPGRL+ + I
Sbjct: 337 RGSMAGSTG-VHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEI 395
Query: 646 PLPDEKSRVAILKANLRK----SPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRE 701
LPDEK R+ IL + + ++ DVD++ LA T FSGA+L + + A A+
Sbjct: 396 GLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNR 455
Query: 702 SIESEIRRERERQTNPSAMEVEEDDPVPEIRRD 734
I++ + E + + +++V D + + D
Sbjct: 456 HIKASTKVEVDME-KAESLQVTRGDFLASLEND 487
>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
Length = 795
Score = 189 bits (479), Expect = 1e-47
Identities = 95/231 (41%), Positives = 147/231 (63%), Gaps = 4/231 (1%)
Query: 474 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIAN 533
V+++D+ G+ + K E++E V Y ++ P++FL+ G KG L GPPGCGKTLLAKA+A
Sbjct: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
Query: 534 ECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNI-GD 592
E Q F+++ GPE + + G A VR +F +AR APC+++ DE+D++ K R + G
Sbjct: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
Query: 593 GGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKS 652
++ +NQ+L EMDGM T +V ++ +TNR DI+D A++RPGRLD+ ++I LP +
Sbjct: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
Query: 653 RVAILKANLRKSPVAKDVDL--EFLAKMTNGFSGADLTEICQRACKLAIRE 701
R I + +L+ + + + LA++T GFSGAD+ IC A A RE
Sbjct: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAARE 535
Score = 167 bits (424), Expect = 3e-41
Identities = 94/231 (40%), Positives = 135/231 (58%), Gaps = 7/231 (3%)
Query: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260
V + D+ G + +++E V+ L+ P F +G K P+G LL GPPG GKTL+A+AVA
Sbjct: 306 VSFKDVAGMHEAKLEVREFVDY-LKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVAT 364
Query: 261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKT---- 316
E F + GPE + + G + +R F+EA AP I++IDE+DA+ KR T
Sbjct: 365 EAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGF 424
Query: 317 HGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376
E + ++QLL MDG+ HVIV+A+TNR + +D AL R GR DR V I +P
Sbjct: 425 SNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQE 484
Query: 377 RLEILQIHTKNMKLADDVDL--EQVANETHGHVGADLAALCSEAALQAIRK 425
R EI + H K++KL +++A T G GAD+A +C+EAAL A R+
Sbjct: 485 RREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAARE 535
>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 189 bits (479), Expect = 1e-47
Identities = 117/299 (39%), Positives = 168/299 (56%), Gaps = 20/299 (6%)
Query: 465 RETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGK 524
R+ V P + W+DI LE+ K+ L+E V P+ PD F K P KGVL GPPG GK
Sbjct: 196 RDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPD-FFKGIRRPWKGVLMVGPPGTGK 254
Query: 525 TLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAK 584
T+LAKA+A EC F ++ L + + GESE VR +F+ AR AP +F DE+DSI
Sbjct: 255 TMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICS 314
Query: 585 ARGGNIGDGGGAADRVINQILTEMDGM-------STKKNVFIIGATNRPDIIDPAILRPG 637
RG D A+ RV +++L +MDG+ K V ++ ATN P ID A+ R
Sbjct: 315 RRG--TSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR-- 370
Query: 638 RLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKL 697
RL++ IYIPLP K R +LK NLR+ + D+ LE +A+ G+SGAD+T +C+ A +
Sbjct: 371 RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLM 430
Query: 698 AIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYE 756
A+R I + E R + +++ + + FE A++ +SVS D+ KYE
Sbjct: 431 AMRRRING-LSPEEIRALSKEELQM-------PVTKGDFELALKKIAKSVSAADLEKYE 481
Score = 172 bits (435), Expect = 1e-42
Identities = 102/266 (38%), Positives = 156/266 (58%), Gaps = 11/266 (4%)
Query: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260
+ +DDI + ++E V LP+ P FK I +P +G+L+ GPPGTGKT++A+AVA
Sbjct: 205 IHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTMLAKAVAT 263
Query: 261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR-EKTHGE 319
E G FF ++ + SK GESE +R FE A AP IFIDE+D+I +R E
Sbjct: 264 ECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHE 323
Query: 320 VERRIVSQLLTLMDGL-------KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIP 372
RR+ S+LL MDG+ V+V+AATN P ID ALRR R ++ + I +P
Sbjct: 324 ASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLP 381
Query: 373 DATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDL 432
A GR E+L+I+ + ++L D+ LE +A + G+ GAD+ +C +A+L A+R++++ +
Sbjct: 382 TAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSP 441
Query: 433 EDETIDAEVMNSLAVTMDDFRWALSQ 458
E+ ++ + VT DF AL +
Sbjct: 442 EEIRALSKEELQMPVTKGDFELALKK 467
>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 189 bits (479), Expect = 1e-47
Identities = 117/299 (39%), Positives = 168/299 (56%), Gaps = 20/299 (6%)
Query: 465 RETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGK 524
R+ V P + W+DI LE+ K+ L+E V P+ PD F K P KGVL GPPG GK
Sbjct: 196 RDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPD-FFKGIRRPWKGVLMVGPPGTGK 254
Query: 525 TLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAK 584
T+LAKA+A EC F ++ L + + GESE VR +F+ AR AP +F DE+DSI
Sbjct: 255 TMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICS 314
Query: 585 ARGGNIGDGGGAADRVINQILTEMDGM-------STKKNVFIIGATNRPDIIDPAILRPG 637
RG D A+ RV +++L +MDG+ K V ++ ATN P ID A+ R
Sbjct: 315 RRG--TSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR-- 370
Query: 638 RLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKL 697
RL++ IYIPLP K R +LK NLR+ + D+ LE +A+ G+SGAD+T +C+ A +
Sbjct: 371 RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLM 430
Query: 698 AIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYE 756
A+R I + E R + +++ + + FE A++ +SVS D+ KYE
Sbjct: 431 AMRRRING-LSPEEIRALSKEELQM-------PVTKGDFELALKKIAKSVSAADLEKYE 481
Score = 172 bits (435), Expect = 1e-42
Identities = 102/266 (38%), Positives = 156/266 (58%), Gaps = 11/266 (4%)
Query: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVAN 260
+ +DDI + ++E V LP+ P FK I +P +G+L+ GPPGTGKT++A+AVA
Sbjct: 205 IHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIR-RPWKGVLMVGPPGTGKTMLAKAVAT 263
Query: 261 ETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR-EKTHGE 319
E G FF ++ + SK GESE +R FE A AP IFIDE+D+I +R E
Sbjct: 264 ECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHE 323
Query: 320 VERRIVSQLLTLMDGL-------KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIP 372
RR+ S+LL MDG+ V+V+AATN P ID ALRR R ++ + I +P
Sbjct: 324 ASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLP 381
Query: 373 DATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDL 432
A GR E+L+I+ + ++L D+ LE +A + G+ GAD+ +C +A+L A+R++++ +
Sbjct: 382 TAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSP 441
Query: 433 EDETIDAEVMNSLAVTMDDFRWALSQ 458
E+ ++ + VT DF AL +
Sbjct: 442 EEIRALSKEELQMPVTKGDFELALKK 467
>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
Length = 491
Score = 187 bits (476), Expect = 3e-47
Identities = 120/304 (39%), Positives = 170/304 (55%), Gaps = 30/304 (9%)
Query: 465 RETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGK 524
R+ + + P V W+DI L + K+ L+E V P+ P+ F K P KGVL GPPG GK
Sbjct: 197 RDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPE-FFKGIRRPWKGVLMVGPPGTGK 255
Query: 525 TLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAK 584
TLLAKA+A EC+ F ++ L + + GESE VR +F+ AR +P +F DE+DSI
Sbjct: 256 TLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICS 315
Query: 585 ARGGNIGDGGGAADRVINQILTEMDGM-------STKKNVFIIGATNRPDIIDPAILRPG 637
RG + A+ RV ++L +MDG+ K V ++ ATN P ID A+ R
Sbjct: 316 RRG--TSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR-- 371
Query: 638 RLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKL 697
RL++ IYIPLP K R +L+ +LR+ +A DVDL +A+ G+SGAD+T +C+ A +
Sbjct: 372 RLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLM 431
Query: 698 AIRESIE----SEIRR-ERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDI 752
A+R IE EIR +E P+ ME FE A++ +SVS DI
Sbjct: 432 AMRRRIEGLTPEEIRNLSKEEMHMPTTME-------------DFEMALKKVSKSVSAADI 478
Query: 753 RKYE 756
+YE
Sbjct: 479 ERYE 482
Score = 179 bits (454), Expect = 9e-45
Identities = 119/312 (38%), Positives = 178/312 (57%), Gaps = 21/312 (6%)
Query: 167 ETDPSPYCIVAPDT-VIHCEG------EPIKREDEEESLNEVGYDDIGGCRKQLAQIKEM 219
E + SP + P+T G E ++R+ ++ N V +DDI + +KE
Sbjct: 166 EKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPN-VRWDDIADLVEAKKLLKEA 224
Query: 220 VELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLA 279
V LP+ P FK I +P +G+L+ GPPGTGKTL+A+AVA E FF ++ + SK
Sbjct: 225 VVLPMWMPEFFKGIR-RPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYR 283
Query: 280 GESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR-EKTHGEVERRIVSQLLTLMDGLKQR 338
GESE +R FE A +PA IFIDE+D+I +R E RR+ ++LL MDG+
Sbjct: 284 GESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGT 343
Query: 339 AH-------VIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLA 391
+ V+V+AATN P ID ALRR R ++ + I +P A GR E+L+I + ++LA
Sbjct: 344 SENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPSAKGREELLRISLRELELA 401
Query: 392 DDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMD-LIDLEDETIDAEVMNSLAVTMD 450
DDVDL +A G+ GAD+ +C +A+L A+R++++ L E + E M+ + TM+
Sbjct: 402 DDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMH-MPTTME 460
Query: 451 DFRWALSQSNPS 462
DF AL + + S
Sbjct: 461 DFEMALKKVSKS 472
>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
Length = 773
Score = 178 bits (452), Expect = 2e-44
Identities = 102/245 (41%), Positives = 142/245 (57%), Gaps = 5/245 (2%)
Query: 469 VEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLA 528
V++ VT+E + G+E+ K+ELQE+V++ +++P KF G KG+L GPPG GKTLLA
Sbjct: 331 VQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLA 389
Query: 529 KAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGG 588
+A+A E F G E M+ G + +R +F +A+ APCV+F DELDS+ G
Sbjct: 390 RAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVG---GK 446
Query: 589 NIGDGGGAADR-VINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPL 647
I R INQ+L EMDG + V IIGATN P+ +D A++RPGR D + +P
Sbjct: 447 RIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPR 506
Query: 648 PDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEI 707
PD K R ILK L K + VD E +A+ T GFSGA+L + +A A + E
Sbjct: 507 PDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVT 566
Query: 708 RRERE 712
+E E
Sbjct: 567 MKELE 571
Score = 173 bits (438), Expect = 7e-43
Identities = 97/238 (40%), Positives = 141/238 (59%), Gaps = 2/238 (0%)
Query: 198 LNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARA 257
+ V ++ + G + +++E+VE L++P F +G K P+GILL GPPGTGKTL+ARA
Sbjct: 333 MKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARA 391
Query: 258 VANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR-EKT 316
VA E F+ +G E G S +R F EA+ NAP +IFIDELD++ KR E
Sbjct: 392 VAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESP 451
Query: 317 HGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376
R+ ++QLL MDG K VI++ ATN P ++D AL R GRFD +V + PD G
Sbjct: 452 MHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKG 511
Query: 377 RLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLED 434
R EIL+ + +K VD E +A T G GA+L L ++AAL+A +++ +++
Sbjct: 512 RTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKE 569
>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
Length = 716
Score = 178 bits (452), Expect = 2e-44
Identities = 102/245 (41%), Positives = 142/245 (57%), Gaps = 5/245 (2%)
Query: 469 VEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLA 528
V++ VT+E + G+E+ K+ELQE+V++ +++P KF G KG+L GPPG GKTLLA
Sbjct: 274 VQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLA 332
Query: 529 KAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGG 588
+A+A E F G E M+ G + +R +F +A+ APCV+F DELDS+ G
Sbjct: 333 RAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVG---GK 389
Query: 589 NIGDGGGAADR-VINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPL 647
I R INQ+L EMDG + V IIGATN P+ +D A++RPGR D + +P
Sbjct: 390 RIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPR 449
Query: 648 PDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEI 707
PD K R ILK L K + VD E +A+ T GFSGA+L + +A A + E
Sbjct: 450 PDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVT 509
Query: 708 RRERE 712
+E E
Sbjct: 510 MKELE 514
Score = 173 bits (438), Expect = 7e-43
Identities = 97/238 (40%), Positives = 141/238 (59%), Gaps = 2/238 (0%)
Query: 198 LNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARA 257
+ V ++ + G + +++E+VE L++P F +G K P+GILL GPPGTGKTL+ARA
Sbjct: 276 MKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARA 334
Query: 258 VANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR-EKT 316
VA E F+ +G E G S +R F EA+ NAP +IFIDELD++ KR E
Sbjct: 335 VAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESP 394
Query: 317 HGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376
R+ ++QLL MDG K VI++ ATN P ++D AL R GRFD +V + PD G
Sbjct: 395 MHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKG 454
Query: 377 RLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLED 434
R EIL+ + +K VD E +A T G GA+L L ++AAL+A +++ +++
Sbjct: 455 RTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKE 512
>gi|31742536 fidgetin-like 1 [Homo sapiens]
Length = 674
Score = 169 bits (429), Expect = 7e-42
Identities = 106/301 (35%), Positives = 158/301 (52%), Gaps = 22/301 (7%)
Query: 464 LRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCG 523
+ E + P V WEDI G+E K ++E+V +P+ PD F P KG+L +GPPG G
Sbjct: 388 MNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGL-RGPPKGILLFGPPGTG 446
Query: 524 KTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIA 583
KTL+ K IA++ A F SI L + W GE E VR +F AR P V+F DE+DS+
Sbjct: 447 KTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLL 506
Query: 584 KARGGNIGDGGGAADRVINQILTEMDGMST--KKNVFIIGATNRPDIIDPAILRPGRLDQ 641
RG + ++ R+ + L ++DG +T + + ++GATNRP ID A R RL +
Sbjct: 507 SQRGDGEHE---SSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVK 561
Query: 642 LIYIPLPDEKSRVAILKANLRKSPVA-KDVDLEFLAKMTNGFSGADLTEICQRACKLAIR 700
+YIPLP+ +R I+ + K + ++E + + ++ FSGAD+T++C+ A IR
Sbjct: 562 RLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIR 621
Query: 701 ESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQ 760
++I Q P I FE A R R SVS D+ YE + +
Sbjct: 622 SLQTADIATITPDQVRP-------------IAYIDFENAFRTVRPSVSPKDLELYENWNK 668
Query: 761 T 761
T
Sbjct: 669 T 669
Score = 156 bits (394), Expect = 8e-38
Identities = 103/293 (35%), Positives = 154/293 (52%), Gaps = 27/293 (9%)
Query: 145 PIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDE---EESLNE- 200
PI K D GGM+ + T+P+ H E +K + E +NE
Sbjct: 343 PIPKQDGGEQNGGMQCKPYGAGPTEPA-----------HPVDERLKNLEPKMIELIMNEI 391
Query: 201 ------VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLI 254
V ++DI G A IKE+V P+ P +F + PP+GILL+GPPGTGKTLI
Sbjct: 392 MDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTGKTLI 450
Query: 255 ARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKRE 314
+ +A+++GA FF I+ + SK GE E +R F A PA+IFIDE+D++ +R
Sbjct: 451 GKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRG 510
Query: 315 KTHGEVERRIVSQLLTLMDG--LKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIP 372
E RRI ++ L +DG ++V+ ATNRP ID A RR R + + I +P
Sbjct: 511 DGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLP 568
Query: 373 DATGRLEI-LQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIR 424
+A+ R +I + + +K + ++EQ+ ++ GAD+ LC EA+L IR
Sbjct: 569 EASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIR 621
>gi|112789543 fidgetin-like 1 [Homo sapiens]
Length = 674
Score = 169 bits (429), Expect = 7e-42
Identities = 106/301 (35%), Positives = 158/301 (52%), Gaps = 22/301 (7%)
Query: 464 LRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCG 523
+ E + P V WEDI G+E K ++E+V +P+ PD F P KG+L +GPPG G
Sbjct: 388 MNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGL-RGPPKGILLFGPPGTG 446
Query: 524 KTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIA 583
KTL+ K IA++ A F SI L + W GE E VR +F AR P V+F DE+DS+
Sbjct: 447 KTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLL 506
Query: 584 KARGGNIGDGGGAADRVINQILTEMDGMST--KKNVFIIGATNRPDIIDPAILRPGRLDQ 641
RG + ++ R+ + L ++DG +T + + ++GATNRP ID A R RL +
Sbjct: 507 SQRGDGEHE---SSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVK 561
Query: 642 LIYIPLPDEKSRVAILKANLRKSPVA-KDVDLEFLAKMTNGFSGADLTEICQRACKLAIR 700
+YIPLP+ +R I+ + K + ++E + + ++ FSGAD+T++C+ A IR
Sbjct: 562 RLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIR 621
Query: 701 ESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQ 760
++I Q P I FE A R R SVS D+ YE + +
Sbjct: 622 SLQTADIATITPDQVRP-------------IAYIDFENAFRTVRPSVSPKDLELYENWNK 668
Query: 761 T 761
T
Sbjct: 669 T 669
Score = 156 bits (394), Expect = 8e-38
Identities = 103/293 (35%), Positives = 154/293 (52%), Gaps = 27/293 (9%)
Query: 145 PIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDE---EESLNE- 200
PI K D GGM+ + T+P+ H E +K + E +NE
Sbjct: 343 PIPKQDGGEQNGGMQCKPYGAGPTEPA-----------HPVDERLKNLEPKMIELIMNEI 391
Query: 201 ------VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLI 254
V ++DI G A IKE+V P+ P +F + PP+GILL+GPPGTGKTLI
Sbjct: 392 MDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLR-GPPKGILLFGPPGTGKTLI 450
Query: 255 ARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKRE 314
+ +A+++GA FF I+ + SK GE E +R F A PA+IFIDE+D++ +R
Sbjct: 451 GKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRG 510
Query: 315 KTHGEVERRIVSQLLTLMDG--LKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIP 372
E RRI ++ L +DG ++V+ ATNRP ID A RR R + + I +P
Sbjct: 511 DGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLP 568
Query: 373 DATGRLEI-LQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIR 424
+A+ R +I + + +K + ++EQ+ ++ GAD+ LC EA+L IR
Sbjct: 569 EASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIR 621
>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
Length = 437
Score = 164 bits (415), Expect = 3e-40
Identities = 95/259 (36%), Positives = 152/259 (58%), Gaps = 13/259 (5%)
Query: 468 VVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLL 527
V+E P + W D+ GLE K L+E V P++ P F TP +G+L +GPPG GK+ L
Sbjct: 118 VMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWRGILLFGPPGTGKSYL 176
Query: 528 AKAIANECQ-ANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKAR 586
AKA+A E + F S+ +L++ W GESE V+ +F+ ARQ P ++F DE+DS+ +R
Sbjct: 177 AKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR 236
Query: 587 GGNIGDGGGAADRVINQILTEMDGMSTKKN-VFIIGATNRPDIIDPAILRPGRLDQLIYI 645
N + AA R+ + L +M G+ + ++GATN P ++D AI R R ++ IYI
Sbjct: 237 NENESE---AARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYI 291
Query: 646 PLPDEKSRVAILKANLRKSP-VAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIE 704
PLP+E +R + + +L +P D ++ LA+ T G+SGAD++ I + + +R+ ++
Sbjct: 292 PLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRK-VQ 350
Query: 705 SEIRRER---ERQTNPSAM 720
S ++ +TNPS M
Sbjct: 351 SATHFKKVCGPSRTNPSMM 369
Score = 153 bits (386), Expect = 7e-37
Identities = 99/310 (31%), Positives = 166/310 (53%), Gaps = 13/310 (4%)
Query: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPP-RGILLYGPPGTGKTLIARAVA 259
+ ++D+ G +KE V LP++ P LF G + P RGILL+GPPGTGK+ +A+AVA
Sbjct: 124 IRWNDVAGLEGAKEALKEAVILPIKFPHLFT--GKRTPWRGILLFGPPGTGKSYLAKAVA 181
Query: 260 NETG-AFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHG 318
E + FF ++ ++MSK GESE ++ FE A ++ P+IIFIDE+D++ R +
Sbjct: 182 TEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENES 241
Query: 319 EVERRIVSQLLTLMDGL-KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGR 377
E RRI ++ L M G+ +V+ ATN P +D A+RR RF++ + I +P+ R
Sbjct: 242 EAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEEAAR 299
Query: 378 LEILQIHT-KNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET 436
++ ++H D ++ ++A +T G+ GAD++ + ++ +Q +RK +
Sbjct: 300 AQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVC 359
Query: 437 IDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVP-QVTWEDIGGLEDVKRELQELVQY 495
+ S+ + DD S +P A+ T ++VP E + + D+ R L
Sbjct: 360 GPSRTNPSMMI--DDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSL--ATTR 415
Query: 496 PVEHPDKFLK 505
P + D LK
Sbjct: 416 PTVNADDLLK 425
>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
Length = 361
Score = 161 bits (408), Expect = 2e-39
Identities = 98/276 (35%), Positives = 151/276 (54%), Gaps = 20/276 (7%)
Query: 474 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMT-PSKGVLFYGPPGCGKTLLAKAIA 532
VTW DI GL+DV +L++ V P++ F + P KGVL YGPPGCGKTL+AKA A
Sbjct: 88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATA 147
Query: 533 NECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGD 592
E FI+++ L W+GES+ +F A + P ++F DE+DS + R + +
Sbjct: 148 KEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHE 207
Query: 593 GGGAADRVINQILTEMDGMSTKKN--VFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDE 650
A + Q ++ DG+ T + V ++GATNRP +D AI+R R+ +I P
Sbjct: 208 ---ATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMR--RMPTRFHINQPAL 262
Query: 651 KSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRE 710
K R AILK L+ V + VDL +A+ T+GFSG+DL E+C+ A L +RE +
Sbjct: 263 KQREAILKLILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYV------- 315
Query: 711 RERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRS 746
N ++ E ++D + +++ A+ ++S
Sbjct: 316 -----NSTSEESHDEDEIRPVQQQDLHRAIEKMKKS 346
Score = 145 bits (365), Expect = 2e-34
Identities = 91/241 (37%), Positives = 127/241 (52%), Gaps = 5/241 (2%)
Query: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGV-KPPRGILLYGPPGTGKTLIARAVA 259
V + DI G + +K+ V LP++ LF+ + +PP+G+LLYGPPG GKTLIA+A A
Sbjct: 88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATA 147
Query: 260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGE 319
E G F + + K GES+ F A K P+IIFIDE+D+ R + E
Sbjct: 148 KEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHE 207
Query: 320 VERRIVSQLLTLMDGL--KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGR 377
+ +Q ++L DGL VIVM ATNRP +D A+ R R I P R
Sbjct: 208 ATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMR--RMPTRFHINQPALKQR 265
Query: 378 LEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETI 437
IL++ KN + VDL +VA ET G G+DL +C +AAL +R+ ++ E
Sbjct: 266 EAILKLILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDE 325
Query: 438 D 438
D
Sbjct: 326 D 326
>gi|113426932 PREDICTED: similar to N-ethylmaleimide-sensitive
factor [Homo sapiens]
Length = 563
Score = 161 bits (407), Expect = 3e-39
Identities = 101/273 (36%), Positives = 152/273 (55%), Gaps = 22/273 (8%)
Query: 479 IGGLE----DVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANE 534
IGGL+ D+ R +P P+ + G KG+L YGPPGCGKTLLA+ I
Sbjct: 293 IGGLDKEFSDIFRRAFASRVFP---PEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKM 349
Query: 535 CQANFISI-KGPELLTMWFGESEANVREIFDKARQ--------AAPCVLFFDELDSIAKA 585
A + GPE+L + GESEAN+R++F A + + ++ FDE+D+I K
Sbjct: 350 LNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQ 409
Query: 586 RGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI 645
RG G G D V+NQ+L+++DGM N+ +IG TNRPD+ID A+LRPGRL+ + I
Sbjct: 410 RGSMAGSTG-VHDTVVNQLLSKIDGMEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEI 468
Query: 646 PLPDEKSRVAILKANLRK----SPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRE 701
LPDEK R+ IL + + ++ DVD++ LA T FSGA+L + + A A+
Sbjct: 469 GLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNR 528
Query: 702 SIESEIRRERERQTNPSAMEVEEDDPVPEIRRD 734
I++ + E + + +++V D + + D
Sbjct: 529 HIKASTKVEVDME-KAESLQVMRGDFLASLEND 560
Score = 159 bits (403), Expect = 7e-39
Identities = 102/263 (38%), Positives = 151/263 (57%), Gaps = 18/263 (6%)
Query: 206 IGGCRKQLAQI-KEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGA 264
IGG K+ + I + + P + + +G K +GILLYGPPG GKTL+AR + A
Sbjct: 293 IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNA 352
Query: 265 FF-FLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKREK 315
++NGPEI++K GESE+N+RK F +AE+ II DE+DAI +R
Sbjct: 353 REPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGS 412
Query: 316 THGE--VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPD 373
G V +V+QLL+ +DG++Q +++V+ TNRP+ ID AL R GR + +++IG+PD
Sbjct: 413 MAGSTGVHDTVVNQLLSKIDGMEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPD 472
Query: 374 ATGRLEILQIHTKNMK----LADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDL 429
GRL+IL IHT M+ L+ DVD++++A ET GA+L L A A+ + +
Sbjct: 473 EKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKA 532
Query: 430 IDLEDETIDAEVMNSLAVTMDDF 452
+ +D E SL V DF
Sbjct: 533 STKVE--VDMEKAESLQVMRGDF 553
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.137 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,126,687
Number of Sequences: 37866
Number of extensions: 1434279
Number of successful extensions: 7119
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 6577
Number of HSP's gapped (non-prelim): 352
length of query: 806
length of database: 18,247,518
effective HSP length: 110
effective length of query: 696
effective length of database: 14,082,258
effective search space: 9801251568
effective search space used: 9801251568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.